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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1980125", "l": "ITCH binds DTX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.133", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9837337", "l": "DCAKD phosphorylates DP-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.33", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981606", "l": "Myoglobin binds oxygen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655320", "l": "Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25056", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+) => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60717", "l": "(1R,3R)-chrysanthemal + H2O + NADP(+) => (1R,3R)-chrysanthemate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692228", "l": "DMRT1 binds the SOX9 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029270", "l": "Recruitment of PLCgamma to membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8980691", "l": "RHOA GEFs activate RHOA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17370", "l": "glycyrrhizin + H2O => 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799246", "l": "CHEK1 phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75367", "l": "cytidine(in) = cytidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72722", "l": "eIF2 activation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31072", "l": "(S)-2-methyl-3-oxopropanoate + L-alanine => (S)-3-amino-2-methylpropanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050262", "l": "ribosylnicotinamide kinase activity", "d": ["Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H+ + nicotinamide mononucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54068", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + sesterfisherol", "d": [], "t": []}, {"i": "EC:4.2.3.176", "l": "\"sesterfisherol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.103", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39441", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.60", "l": "\"dactylysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35095", "l": "choline = acetaldehyde + trimethylamine", "d": [], "t": []}, {"i": "EC:4.3.99.4", "l": "\"choline trimethylamine-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132260", "l": "Complement factor I inactivates surface-bound C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71907", "l": "GDP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77809", "l": "2-dehydro-D-glucose + H2O2 + L-valine => H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-valine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34045", "l": "5''-phosphoribostamycin + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + neamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16557", "l": "2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.45", "l": "\"aminocarboxymuconate-semialdehyde decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78800", "l": "a D-alpha-amino acid + O2 => a 2-iminocarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015047", "l": "NADPH-cytochrome-c2 reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59358", "l": "H(+) + lactobionate => H2O + lactobiono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58594", "l": "1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018392", "l": "glycoprotein 3-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70509", "l": "dimethylallyl phosphate + H(+) + phosphate => dimethylallyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77428", "l": "benzaldehyde + hydrogen cyanide => (S)-mandelonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0046624", "l": "sphingolipid transporter activity", "d": ["Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835121", "l": "Heparin binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42135", "l": "isonocardicin C <=> nocardicin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9864415", "l": "AAC1 imports a proton (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56424", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43347", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) <=> [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32019", "l": "(2E,6E)-farnesyl diphosphate = beta-cubebene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.128", "l": "\"beta-cubebene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60265", "l": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52995", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine <=> [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11544", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine", "d": [], "t": []}, {"i": "EC:3.5.1.26", "l": "\"N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35829", "l": "spermidine + urea => H2O + N(1)-(3-aminopropyl)agmatine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696605", "l": "USP12, USP26 deubiquitinate AR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019894", "l": "kinesin binding", "d": ["Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654514", "l": "KAL1 binds FGFR1c (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36174", "l": "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol <=> 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33684", "l": "H(+) + L-serine + octadecanoyl-CoA => 3-oxoeicosasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30810", "l": "L-pipecolate + NAD(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32868", "l": "myo-inositol(out) => myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10970", "l": "an acyl-CoA + GDP + phosphate => a carboxylate + CoA + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35834", "l": "2-oxoglutarate + kanamycin B + O2 <=> 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40413", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009541", "l": "ESR1 binds to TFF1 gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033509", "l": "USP9X binds Ub:PEX5L (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64370", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2 => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948180", "l": "Peroxynitrite oxidizes Cys residues (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65167", "l": "benzoyl-CoA + hexan-3-ol <=> CoA + hexan-3-yl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34663", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16007", "l": "5-dehydro-4-deoxy-D-glucarate + H2O => galactarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013145", "l": "RAC1 binds effectors at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23283", "l": "acetyl-CoA + cysteamine <=> CoA + S-acetylcysteamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66994", "l": "3-methylpentanoyl-CoA + AMP + diphosphate => 3-methylpentanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43997", "l": "2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2 => a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427570", "l": "Group 3 - Selective Cl- transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18893", "l": "a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.239", "l": "\"flavonol-3-O-glucoside glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16606", "l": "dodecanoyl-CoA + H2O + oxaloacetate => (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28446", "l": "1-deoxy-D-xylulose(in) = 1-deoxy-D-xylulose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604451", "l": "NOTCH4 binds FLT4 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034917", "l": "2-methylhex-2-enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27752", "l": "2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine => 2'-deoxyinosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40921", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75720", "l": "CoA-disulfide + H2O => 4'-phosphopantetheinyl-CoA disulfide + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53995", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68615", "l": "Formation of ORC(1-6) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26254", "l": "H(+) + isopimara-7,15-dienol + NADPH + O2 => 2 H2O + isopimara-7,15-dienal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11017", "l": "allantoate + H2O => (S)-ureidoglycolate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18495", "l": "CoA + H(+) + N-benzoylglycine => benzoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54123", "l": "coelenterazine h + O2 <=> coelenterazine h dioxetanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17149", "l": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.1", "l": "\"unspecific monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45490", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939201", "l": "ESR dimerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24967", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69338", "l": "(Z)-alkanethial oxide => (E)-alk-1-en-1-SO-peroxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11411", "l": "H(+) + H2O + riboflavin <=> lumichrome + ribitol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63981", "l": "4-thiouridine + ATP => 4-thiouridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55516", "l": "11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] = 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76688", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione => (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690669", "l": "CD22 binds itself to form homo-oligomers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59697", "l": "D-cellotetraono-1,5-lactone + H2O => D-cellotetraonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55055", "l": "H2O + pentanoyl-CoA <=> CoA + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56919", "l": "3beta-hydroxy-5alpha-androstan-17-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30864", "l": "4-O-phospho-L-tyrosine + H2O => L-tyrosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416358", "l": "G alpha (q) inhibits PI3K alpha (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-184323", "l": "Monoubiquitination of N-myristoyl GAG polyprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350477", "l": "RHOGEF2 stimulates nucleotide exchange of RHO1:GDP complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682011", "l": "LC3 binds ATG7 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950347", "l": "IL12A:IL12B translocates from late endosome lumen to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975040", "l": "KRAB-ZNF / KAP Interaction (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32766", "l": "(3R)-3-methyl-D-ornithine + ATP + L-lysine <=> (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26323", "l": "3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine => resorcinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1467466", "l": "ABCA4 mediates atRAL transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112436", "l": "Formation of Elongin complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15599", "l": "a Fe(III)-siderophore(in) + ADP + H(+) + phosphate => a Fe(III)-siderophore(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640368", "l": "Addition of Tegument to HCMV Nucleocapsid C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19438", "l": "nicotinate + UDP-alpha-D-glucose => N-(beta-D-glucosyl)nicotinate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202203", "l": "Recruitment of PI3K to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25057", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 <=> (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50919", "l": "a carboxylate + ATP + H(+) + NADPH <=> AMP + an aldehyde + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877345", "l": "IL2 gene expression is stimulated by RUNX1 and NFATC2 and repressed by FOXP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420906", "l": "Formation of PPAT tetramers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849908", "l": "SALM4 binds flotillin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39648", "l": "AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35289", "l": "ADP + chloramphenicol(out) + H(+) + phosphate => ATP + chloramphenicol(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865098", "l": "UBA6 conjugates ubiquitin to UBA6 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28863", "l": "H(+)(out) + lactose(in) = H(+)(in) + lactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420206", "l": "Phosphorylation of SRC-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53965", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin => gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51597", "l": "2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] => 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682598", "l": "ATM phosphorylates HERC2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724290", "l": "GNRHR2 binds GNRH1,2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53915", "l": "butanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21291", "l": "D-glucose + sn-glycerol 3-phosphate <=> D-glucose 6-phosphate + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77225", "l": "5'-deoxyadenosine + cob(III)alamin + geneticin + L-methionine => gentamicin X2 + methylcob(III)alamin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23059", "l": "urea <=> cyanamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688459", "l": "RIPK3 binds HSP90:CDC37 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237129", "l": "Acireductone is created (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374173", "l": "AGT(34-41) binds to AGTR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700149", "l": "Active ALK binds PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59285", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O => D-glucose + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.373", "l": "\"alpha-(1->2) branching sucrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564179", "l": "Collagen type XI degradation by MMP1,2,3,9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58571", "l": "15alpha-stemmadenine + acetyl-CoA <=> CoA + O-acetyl-15alpha-stemmadenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34354", "l": "(2E)-geranial + H2O + NAD(+) <=> geranate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018861", "l": "4-chlorobenzoate-CoA ligase activity", "d": ["Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. This reaction requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509831", "l": "ITPA hydrolyses XTP to XMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168809", "l": "SOCS binding to GHR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72831", "l": "3',3'-cGAMP + H2O = G[3'-5']pAp[3'] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3828025", "l": "DCN (decorin) degradation by MMP14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015643", "l": "toxic substance binding", "d": ["Binding to a toxic substance, a poisonous substance that causes damage to biological systems."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15983", "l": "CO2 + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52643", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA <=> (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31524", "l": "2-oxoglutarate + 2 H(+) + O2 => 3 CO2 + ethene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0045140", "l": "inositol phosphoceramide synthase activity", "d": ["Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide + diacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19802", "l": "(R)-4'-phosphopantetheine + ATP + H(+) => 3'-dephospho-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24738", "l": "(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76713", "l": "(15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O => (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39140", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.202", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22493", "l": "H2O + N-formimidoyl-L-glutamate => formamide + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50672", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O = [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21150", "l": "5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP => indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75086", "l": "32-oxo-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374673", "l": "L1 binds RanBPM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357445", "l": "PAK1-3 dimer disassociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77689", "l": "a ganglioside GalNAc-GD1a (d18:1(4E)) + H(+) + UDP => a ganglioside GD1a (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647632", "l": "CASP3 cleaves GSDME (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705584", "l": "HMGCR dimer binds statins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53019", "l": "chlorohydroquinone + 2 glutathione <=> chloride + glutathione disulfide + H(+) + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71448", "l": "D-alanine(in) + Na(+)(in) => D-alanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106376", "l": "2-hydroxyphytanoyl-CoA lyase activity", "d": ["Catalysis of the reaction: 2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA."], "t": []}, {"i": "RHEA:25355", "l": "2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55819", "l": "a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49785", "l": "chenodeoxycholoyl-CoA + taurine => CoA + H(+) + taurochenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213017", "l": "Auto-ubiquitination of TRAF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49885", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047387", "l": "serine-ethanolaminephosphate phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + serine phosphoethanolamine = H+ + phosphoethanolamine + serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66186", "l": "3',5'-cyclic AMP(out) + ADP + H(+) + phosphate => 3',5'-cyclic AMP(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879930", "l": "STAT5 is recruited by JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28663", "l": "H2O + melibiose = D-galactose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34075", "l": "an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:2.3.1.275", "l": "\"acyl phosphate:glycerol-3-phosphate acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34763", "l": "(S,S)-tartrate(out) + succinate(in) = (S,S)-tartrate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420688", "l": "GABAB heterodimeric receptor binds GABA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73187", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate = (2R,3S,11R)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38837", "l": "1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805276", "l": "CDK5 phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106377", "l": "2-hydroxy-ATP hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41922", "l": "(3R)-hydroxyoctadecanoyl-[ACP] + NADP(+) => 3-oxooctadecanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78531", "l": "beta-D-glucosylceramide + H2O = a  beta-D-glucosyll-(1<->1')-sphingoid base + a fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102191", "l": "4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) = 5alpha-cholesta-7,24-dien-3-one + NADH(2-) + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72621", "l": "Ribosomal scanning  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592297", "l": "Full activation of MMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66999", "l": "2-methylpentanoate + ATP + CoA <=> 2-methylpentanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351901", "l": "Caspase-mediated cleavage of MST3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62041", "l": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate => N-octanoylsphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768937", "l": "NPAS4 gene transcription is stimulated by NPAS4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33201", "l": "butanal + H(+) + NADH => butan-1-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160104", "l": "tRNA (guanine(26)-N2)-dimethyltransferase activity", "d": ["Catalysis of the reaction:guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H+ + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42179", "l": "(9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604731", "l": "Autocatalytic activation of MMP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12440", "l": "H2O + L-saccharopine + NAD(+) = 2-oxoglutarate + H(+) + L-lysine + NADH", "d": [], "t": []}, {"i": "EC:1.5.1.7", "l": "\"saccharopine dehydrogenase (NAD(+), L-lysine-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63004", "l": "(11Z,14Z)-eicosadienamide + H2O = (11Z,14Z)-eicosadienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41679", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + ATP <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23341", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate => D-arabinose + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042410", "l": "6-carboxyhexanoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H+ + pimelyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418091", "l": "F2R binds ARRB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73367", "l": "D-xylose(out) + 2 Na(+)(out) = D-xylose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17783", "l": "formate + L-methionine => H2O + N-formyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54887", "l": "L-arginyl-[protein] + NADP(+) <=> H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72150", "l": "AH2 + S-adenosyl-L-methionine + UTP <=> 3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32226", "l": "(6S)-NADHX + ADP <=> AMP + H(+) + NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72498", "l": "glutarate(in) + prostaglandin E2(out) <=> glutarate(out) + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34757", "l": "D-glucose + N-acyl-15-methylhexadecasphing-4-enine => H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759158", "l": "SQSTM1 oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047049", "l": "(R)-2-hydroxy-fatty acid dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxystearate + NAD+ = 2-oxostearate + H+ + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20697", "l": "2 H(+) + 2 superoxide => H2O2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453818", "l": "Defective STRA6 does not transport atROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10230", "l": "cis-aconitate + H2O => citrate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.16", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26010", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71155", "l": "TAT deaminates tyrosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37099", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674562", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69375", "l": "2-hydroxyhexanoate + O2 <=> 2-oxohexanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940007", "l": "MMP13 gene expression is stimulated by RUNX2:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37730", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34271", "l": "2-nitroimidazole + H2O = 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite", "d": [], "t": []}, {"i": "EC:3.5.99.9", "l": "\"2-nitroimidazole nitrohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25782", "l": "3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate => H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653622", "l": "Defective SLC35A3 does not exchange UDP-GlcNAc for UMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32975", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5444516", "l": "Formation of MSH2:MSH6 Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60932", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69847", "l": "a 5,6-dihydrouridine in RNA + NADP(+) = a uridine in RNA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57929", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine => ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448627", "l": "Interleukin-35 translocates from the ER lumen to the extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696980", "l": "Spike trimer glycoside chains get additional branches (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75486", "l": "estrone 3-sulfate(out) + n H(+)(out) <=> estrone 3-sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29388", "l": "CTP + H2O => CDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169468", "l": "MCM2-7 mediated fork unwinding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29793", "l": "ADP + glutathione(in) + H(+) + phosphate => ATP + glutathione(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72400", "l": "2-oxoglutarate(out) + estrone 3-sulfate(in) => 2-oxoglutarate(in) + estrone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824849", "l": "G or G analog binds C-ter TLR7 GoF variant  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47091", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) <=> 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186780", "l": "PI3-kinase binds to the active receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58262", "l": "ADP-D-ribose + L-tyrosyl-[protein] => H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706312", "l": "Active FLT3 binds to LCK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26132", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48264", "l": "H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] = H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13153", "l": "(R)-glycerate + CO2 + NAD(+) = 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112392", "l": "Resumption of elongation after recovery from pausing (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47205", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858645", "l": "MITF-M and CTNNB1-dependent CCND1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727349", "l": "XDH dehydrogenates xanthine to form urate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62212", "l": "3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] = gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51620", "l": "CTP + formate + H(+) = CO2 + dCTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0038187", "l": "pattern recognition receptor activity", "d": ["Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005274", "l": "allantoin:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985157", "l": "OAS3 binds viral dsRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35161", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol => (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191656", "l": "Closure of gap junction (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70382", "l": "3-oxosphinganine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8962050", "l": "TYMS gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098621", "l": "O-phosphoseryl-tRNA(Sec) selenium transferase activity", "d": ["Catalysis of the reaction: O-phosphoseryl-tRNA(Sec) + selenophosphoric acid + H2O => L-selenocysteinyl-tRNA(Sec) + 2 phosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20891", "l": "3-hydroxy-2-methylpropanoyl-CoA + H2O <=> 3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042380", "l": "hydroxymethylbutenyl pyrophosphate reductase activity", "d": ["Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36190", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37098", "l": "(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51959", "l": "(E)-2-methylpropanal oxime <=> (Z)-2-methylpropanal oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25621", "l": "geranylgeranyl diphosphate = tuberculosinyl diphosphate", "d": [], "t": []}, {"i": "EC:5.5.1.16", "l": "\"halimadienyl-diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514865", "l": "cGMP dissociates from CNG channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800490", "l": "ATM phosphorylates PIDD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0005525", "l": "GTP binding", "d": ["Binding to GTP, guanosine triphosphate."], "t": []}, {"i": "REACT:R-HSA-167429", "l": "The receptor:G-protein complex  binds GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78437", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50436", "l": "prostaglandin H1 = prostaglandin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74169", "l": "formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine => H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25121", "l": "(S)-2-amino-6-oxohexanoate = H(+) + H2O + L-1-piperideine-6-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.15", "l": "\"N(8)-acetylspermidine oxidase (propane-1,3-diamine-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951644", "l": "Release of mature NEDD8 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110307", "l": "REV1 binds AP-dsDNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416690", "l": "SEMA4A binds to PLXND1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66078", "l": "H2O + kynurenate + L-2-aminopentanoate => 2-oxopentanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085020", "l": "Cytosolic Neu5Ac translocates to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187506", "l": "Translocation of p27 to the nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66216", "l": "asc-C7-CoA + O2 = asc-DeltaC7-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935731", "l": "ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36099", "l": "benzoate + S-adenosyl-L-methionine = methyl benzoate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.273", "l": "\"benzoate O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63211", "l": "5-amino-6-(D-ribitylamino)uracil + glyoxal <=> 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372819", "l": "PCK2 phosphorylates OA to yield PEP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443418", "l": "GP1b signaling involves c-Src (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37280", "l": "ATP + H2O + L-alanyl-L-histidine(out) => ADP + H(+) + L-alanyl-L-histidine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49333", "l": "2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450550", "l": "PKCalpha phosphorylates HuR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16772", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58312", "l": "25-substituted-cholesteryl beta-D-glucoside + H2O = 25-substituted-cholesterol + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43724", "l": "(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.128", "l": "\"farnesoate epoxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805640", "l": "AKT phosphorylates KAT6A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004914", "l": "interleukin-5 receptor activity", "d": ["Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12710", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803935", "l": "TP53 binds the PLAGL1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69359", "l": "H(+) + hypobromite + L-tyrosyl-[protein] <=> 3-bromo-L-tyrosyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.17", "l": "\"quinoline 2-oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033520", "l": "TYSND1 cleaves TYSND1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788999", "l": "HV1-mediated H+ transfer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77143", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047745", "l": "chlorogenate hydrolase activity", "d": ["Catalysis of the reaction: chlorogenate + H2O = (-)-quinate + cis-caffeate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419645", "l": "Dimerization of LIMK1 by Hsp90 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013158", "l": "CDC42 GDIs block activation of CDC42 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203973", "l": "Vesicle budding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.328", "l": "\"nicotine blue oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47338", "l": "16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0008527", "l": "taste receptor activity", "d": ["Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18258", "l": "coproporphyrinogen III + 2 H(+) + O2 => 2 CO2 + 2 H2O + protoporphyrinogen IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68797", "l": "D-maltose + H2O => alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71173", "l": "GSTZ1 isomerizes 4-MAA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73509", "l": "7-hydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 7,8-dihydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.27", "l": "\"cyclopenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047851", "l": "dicarboxylate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + an omega-dicarboxylic acid + CoASH= AMP + diphosphate + an omega-carboxyacyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0070626", "l": "(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity", "d": ["Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13252", "l": "(R)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191303", "l": "FDPS dimer transfers IPPP to GPP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62964", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54710", "l": "H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18048", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O <=> alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41181", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+) => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173740", "l": "Factor B binds to C3(H2O) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52179", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18058", "l": "O2 + Watasenia luciferin => CO2 + hnu + oxidized Watasenia luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0140410", "l": "monoatomic cation:bicarbonate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16429", "l": "ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": [], "t": []}, {"i": "EC:6.3.2.9", "l": "\"UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788867", "l": "FN3K phosphorylates ketosamines (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49669", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate => deoxyviolaceinate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803719", "l": "TP53 binds ZNF385A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16542", "l": "9-cis-violaxanthin + O2 => (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0097642", "l": "calcitonin family receptor activity", "d": ["Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678925", "l": "NR3C1 binds NR3C1 agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59330", "l": "D-xylonate + H(+) => D-xylono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382054", "l": "PDGF binds to extracellular matrix proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426489", "l": "RISC binds inexactly matching target RNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53949", "l": "ATP + holo-[BtrI ACP] + L-glutamate => ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26474", "l": "beta-D-galactosyl-(1->4)-L-rhamnose + phosphate = alpha-D-galactose 1-phosphate + L-rhamnopyranose", "d": [], "t": []}, {"i": "EC:2.4.1.247", "l": "\"beta-D-galactosyl-(1->4)-L-rhamnose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13243", "l": "ADP + beta-L-fucose 1-phosphate + H(+) => ATP + L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689630", "l": "BAP1 binds BAP1-interacting complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64967", "l": "dUTP + 2 H2O <=> dUMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50192", "l": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.26", "l": "\"protein xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047604", "l": "acetoin racemase activity", "d": ["Catalysis of the reaction: (S)-acetoin = (R)-acetoin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33222", "l": "ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60307", "l": "N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0038106", "l": "choriogonadotropin hormone binding", "d": ["Binding to choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52741", "l": "glyphosate + H2O + O2 => aminomethylphosphonate + glyoxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694718", "l": "O-glycosylation of 3a is terminated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51581", "l": "a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) => a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40754", "l": "(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13208", "l": "a monosaccharide 1-phosphate + H(+) + UTP <=> a UDP-monosaccharide + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26296", "l": "(1'S,5'S)-averufin + NADPH + O2 <=> 1'-hydroxyversicolorone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27276", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.16", "l": "\"glucosinolate gamma-glutamyl hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77159", "l": "H2O + selenophosphate + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-1-seleno-beta-D-glucosamine + phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696605", "l": "USP12, USP26 deubiquitinate AR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983158", "l": "Trimming of peptides in ER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49654", "l": "H2O + NAD(+) + violaceinate => H(+) + NADH + O2 + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322429", "l": "XIAP monoubiquinates TLE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30168", "l": "D-erythrose 4-phosphate + dihydroxyacetone phosphate => D-sedoheptulose 1,7-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705926", "l": "AR binds AR agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19501", "l": "4-guanidinobutanoate + H2O = 4-aminobutanoate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008913", "l": "lauroyltransferase activity", "d": ["Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68865", "l": "H2O + isomaltose => alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042300", "l": "beta-amyrin synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52352", "l": "(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350598", "l": "Arginine<=>Agmatine+CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66599", "l": "O2 + 2 tyramine <=> 2 dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0072518", "l": "Rho-dependent protein serine/threonine kinase activity", "d": ["Rho GTPase-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103005", "l": "9,10-epoxystearate hydrolase activity", "d": ["Catalysis of the reaction: 9,10-epoxystearate + H2O = (9R,10S)-dihydroxystearate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67156", "l": "1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42851", "l": "8-demethyltetracenomycin C + dTDP-beta-L-rhamnose <=> 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13287", "l": "ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate => ATP + L-cysteine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167147", "l": "Separation of abortive HIV-1 transcript from template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395784", "l": "Nascent CMs transform into mature CMs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58159", "l": "ATP + H2O + 4 Na(+)(in) <=> ADP + H(+) + 4 Na(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381644", "l": "ER calcium channels open in response to activated PKA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47694", "l": "5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B => AH2 + neomycin C + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444100", "l": "PROT mediates L-proline uptake (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38590", "l": "UDP-alpha-D-glucose + vancomycin aglycone <=> devancoaminyl-vancomycin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10011", "l": "[protein]-dithiol + a hydroperoxide <=> [protein]-disulfide + an alcohol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.71648590403835", "identifiers": [{"i": "GO:0031543", "l": "peptidyl-proline dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-532549", "l": "MPI isomerises Fru6P to Man6P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21229", "l": "alpha-maltose => beta-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30252", "l": "2 a ubiquinol + n H(+)(in) + O2 => 2 a ubiquinone + n H(+)(out) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170986", "l": "Ral-GDS binds to Ras-GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.315", "l": "\"diglucosyl diacylglycerol synthase (1,6-linking)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004573", "l": "Glc3Man9GlcNAc2 oligosaccharide glucosidase activity", "d": ["Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14386", "l": "a dolichyl diphosphate + H2O => a dolichyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50552", "l": "prostaglandin C1 = prostaglandin B1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73565", "l": "dGDP(in) + UTP(out) => dGDP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61663", "l": "(2E)-geraniol + ATP <=> (2E)-geranyl phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9861660", "l": "ME1 tetramer decarboxylates OA to PYR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43474", "l": "14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22597", "l": "cephalosporin C + H2O => acetate + deacetylcephalosporin C + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661230", "l": "MT1A binds arsenic (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41167", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20860", "l": "(1S,6R)-isopiperitenol + NAD(+) = (6R)-isopiperitenone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.223", "l": "\"isopiperitenol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76772", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] => 1,3-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202726", "l": "F11R dimerises (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54275", "l": "2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17234", "l": "L-fucose => L-fuculose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830373", "l": "Expression of PCDH19 in the nephric duct (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36307", "l": "(E)-caffeoyl-CoA + H2O = 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51815", "l": "ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32662", "l": "(6E)-8-hydroxygeraniol + 2 NADP(+) <=> (6E)-8-oxogeranial + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61361", "l": "ATP + H2O + pheophorbide a(in) => ADP + H(+) + pheophorbide a(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0004753", "l": "saccharopine dehydrogenase activity", "d": ["Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610722", "l": "CK1 phosphorylates p-GLI3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25456", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-humulene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878056", "l": "RUNX1:CBFB binds EP300 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195378", "l": "Homodimerization of VEGF proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67367", "l": "H2O + L-threonyl-L-serine <=> L-serine + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944236", "l": "Association of procollagen type XIV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9650165", "l": "ASIC trimers bind H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12705", "l": "[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28304", "l": "diphosphate + germacrene C => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448744", "l": "IL20RA binds IL20RB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944457", "l": "MAF1 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25735", "l": "L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70798", "l": "H(+)(in) + L-lysine(out) <=> H(+)(out) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.4.-", "l": "\"With a disulfide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71388", "l": "L-pipecolate(in) + Na(+)(in) => L-pipecolate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68076", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051669", "l": "fructan beta-fructosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24117", "l": "(2E)-geranyl diphosphate + H2O => (S)-linalool + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72868", "l": "3',3',3'-cAAG + H2O => A[3'-5']pG[3'-5']pAp[3'] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14464", "l": "(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose <=> (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78196", "l": "a 3beta-hydroxysteroid + a triacylglycerol => a 1,2-diacylglycerol + a 3beta-hydroxysteroid ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40554", "l": "demethylphylloquinol + S-adenosyl-L-methionine <=> H(+) + phylloquinol + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009700", "l": "IL2RB and IL2RG are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14306", "l": "ATP + L-proline + tRNA(Pro) => AMP + diphosphate + L-prolyl-tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047181", "l": "tetrahydroxybenzophenone synthase activity", "d": ["Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879562", "l": "SLCO2B1 has a narrow substrate specificity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48437", "l": "H2O + pentanoate ester => an aliphatic alcohol + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64400", "l": "an L-amino acid tripeptide(out) + H(+)(out) = an L-amino acid tripeptide(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53896", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.3.7", "l": "\"alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.745825357329565", "identifiers": [{"i": "GO:0015662", "l": "P-type ion transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026464", "l": "BDNF-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964619", "l": "PAK1 binds ARHGEF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41214", "l": "(indol-3-yl)acetate + H(+) + NADH + O2 <=> 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252001", "l": "ATP1B4 binds SNW1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043827", "l": "tRNA (adenine(57)-N1)/(adenine(58)-N1)-methyltransferase activity", "d": ["Catalysis of the reaction: adenosine57/adenosine58 in tRNA + 2 S-adenosyl-L-methionine = 2 H+ + N1-methyladenosine57/N1-methyladenosine58 in tRNA + 2 S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390641", "l": "ADRA1A,B,D bind ADR,NAd (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44013", "l": "(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) => (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51390", "l": "CoA + H(+) + N-acetyl-dopamine => acetyl-CoA + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30231", "l": "H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine = (2E,6E)-farnesal + H2O2 + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873830", "l": "STARD7 transports PC from ER membrane to mitochondrial outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16006", "l": "galactarate => 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984689", "l": "Kinesin-7 is a dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209321", "l": "Phosphorylated STAT92E dissociates from HOP and DOME and dimerises (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58516", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.-", "l": "\"With a disulfide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391942", "l": "IP receptor can bind prostacyclin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17647", "l": "N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate => H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76390", "l": "ATP + L-glutamate + N(6)-hydroxy-L-lysine <=> 1-L-glutamo-2-N(6-)L-lysinohydrazine + AMP + diphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58039", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> 8-epi-inunolide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382061", "l": "Extracellular processing of novel PDGFs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75850", "l": "Addition of the third nucleotide on the nascent transcript (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20549", "l": "2 Fe(III)-[cytochrome c] + 2 thiosulfate = 2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate", "d": [], "t": []}, {"i": "EC:1.8.2.2", "l": "\"thiosulfate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43523", "l": "2-carboxy-5-(dihydroxymethyl)furan + O2 <=> 2,5-dicarboxyfuran + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450971", "l": "NNT dimer transfers proton from NADPH to NAD+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19385", "l": "UDP-alpha-D-glucose + vomilenine = H(+) + raucaffricine + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.219", "l": "\"vomilenine glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044654", "l": "starch alpha-glucosidase activity", "d": ["Catalysis of the reaction: starch + H2O = alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350598", "l": "Arginine<=>Agmatine+CO2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55374", "l": "H(+) + jasmonate + methanol => H2O + methyl (-)-jasmonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218806", "l": "FYN autophosphorylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019165", "l": "thiamine kinase activity", "d": ["Catalysis of the reaction: ATP + thiamine = ADP + 2 H+ + thiamine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27275", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912357", "l": "ITCH ubiquitinates DTX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50604", "l": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]", "d": [], "t": []}, {"i": "EC:2.3.1.259", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatF\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46448", "l": "2 L-tyrosyl-tRNA(Tyr) = cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)", "d": [], "t": []}, {"i": "EC:2.3.2.21", "l": "\"cyclo(L-tyrosyl-L-tyrosyl) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450088", "l": "GLUT1 tetramer binds 4xATP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170116", "l": "Myt-1 mediated phosphorylation of Cyclin A:Cdc2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390597", "l": "Release Of ADP From Myosin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54514", "l": "(13R)-9,13-epoxylabd-14-ene + diphosphate => peregrinol diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13918", "l": "(-)-menthol + NADP(+) => (1R,4S)-menthone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46367", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864999", "l": "TGFA gene expression is stimulated by the TFAP2A homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350901", "l": "Iodide is organified (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71312", "l": "chloride(out) + L-alanine(out) + 2 Na(+)(out) => chloride(in) + L-alanine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50361", "l": "(R)-mandelonitrile + O2 => benzoyl cyanide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16314", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O => 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70521", "l": "(R)-synephrine + H(+) + S-adenosyl-L-homocysteine => (R)-octopamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2025890", "l": "Calcineurin binds NFATC1,2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41117", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30036", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 => benzene-1,2,4-triol + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30492", "l": "L-valine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11587", "l": "L-ornithine <=> D-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20359", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) => 3-phenylpropanoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30356", "l": "a quinol + methane + O2 => a quinone + H2O + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0005346", "l": "purine ribonucleotide transmembrane transporter activity", "d": ["Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694409", "l": "Nucleotide exchange on RAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64426", "l": "H(+)(in) + L-leucyl-L-proline(in) => H(+)(out) + L-leucyl-L-proline(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73853", "l": "H(+) + UDP + withanone 27-O-beta-D-glucoside => 27-hydroxywithanone + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029680", "l": "Caspase-7 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51976", "l": "an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863494", "l": "ASICs bind STOML3, (STOM) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031752", "l": "D5 dopamine receptor binding", "d": ["Binding to a D5 dopamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.3", "l": "\"triacylglycerol lipase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74301", "l": "D-isoleucine(in) + D-serine(out) => D-isoleucine(out) + D-serine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50871", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353014", "l": "2-phosphoglycerate <=> 3-phosphoglycerate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.20", "l": "\"trans-1,2-dihydrobenzene-1,2-diol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19471", "l": "H(+) + NAD(+) + 2 nitrate => NADH + 2 nitric oxide + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678925", "l": "NR3C1 binds NR3C1 agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836702", "l": "PKR inhibitors bind PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56845", "l": "nocamycin E + S-adenosyl-L-methionine => nocamycin I + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15360", "l": "5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose <=> demethyllactenocin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19070", "l": "(R)-S-lactoylglutathione => glutathione + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74139", "l": "petunidin + UDP-alpha-D-glucose = petunidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669911", "l": "Phosphorylation of juxtamembrane domain KIT mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54190", "l": "acetate + L-phenylalanine => H2O + N-acetyl-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018747", "l": "RHOQ GEFs activate RHOQ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25381", "l": "2-methylpentadecanal + formyl-CoA => 2-hydroxy-3-methylhexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41089", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18241", "l": "D-lysine = (2R,5S)-2,5-diaminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47349", "l": "a butanoate ester + H2O => an aliphatic alcohol + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64733", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77068", "l": "Activation of GT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805061", "l": "CK2 binds FACT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29090", "l": "(S)-malate + menaquinone-8 <=> menaquinol-8 + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38726", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666046", "l": "SRF:MKL1 binds ITGB1 Gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75925", "l": "4-oxopentanoate + H(+) + NADH + NH4(+) => (S)-4-aminopentanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35522", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62155", "l": "dGMP + dTTP <=> dGDP + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205244", "l": "Recruitment of CBL to KIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44603", "l": "a fatty acid + ATP + H(+) <=> a fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51988", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = 18S-resolvin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000823", "l": "inositol-1,4,5-trisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + 2 ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + 2 ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69882", "l": "6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264865", "l": "Caspase-mediated cleavage of Lamin A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791235", "l": "GADD45A binds AURKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58035", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30497", "l": "H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21621", "l": "FMNH2 + NAD(+) => FMN + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44236", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36801", "l": "a ribonucleoside 5'-phosphate + H(+) + phosphate => a ribonucleoside 5'-diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49215", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45157", "l": "3-oxopropanoyl-CoA + H2O => 3-oxopropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70301", "l": "2,3-dioxo-L-gulonate => H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62706", "l": "2,3-didehydrophenylalanine + glycine => glycyldehydrophenylalanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865994", "l": "GAB1 binds PTPN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912734", "l": "CBL:CRKL binds RAPGEF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51263", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] <=> (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45703", "l": "glycine betaine + H(+) + NADH + O2 <=> formaldehyde + H2O + N,N-dimethylglycine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.77", "l": "\"semenogelase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167072", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031884", "l": "DPAn-6 SPMs translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66557", "l": "dopamine + L-glutaminyl-[protein] => 5-dopaminyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70598", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69415", "l": "2 glutathione + tert-butyl hydroperoxide <=> glutathione disulfide + H2O + tert-butanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59289", "l": "beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O => D-glucose + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22416", "l": "3,4-dihydroxybenzoate + H(+) = catechol + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.63", "l": "\"protocatechuate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72396", "l": "2 chloride(out) + K(+)(out) + Na(+)(out) => 2 chloride(in) + K(+)(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619515", "l": "AMPK phosphorylates MAPT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9842665", "l": "Active LTK binds GRB2:TNK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76301", "l": "L-aspartate(out) + L-cystine(in) => L-aspartate(in) + L-cystine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949145", "l": "VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75277", "l": "(10R,11R)-epoxy-(9S)-hydroxy-(12Z)-octadecenoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47096", "l": "(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.86", "l": "\"trans,polycis-decaprenyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604731", "l": "Autocatalytic activation of MMP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61270", "l": "2-oxohexanoate + H2O2 + NH4(+) => H2O + L-2-aminohexanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252072", "l": "AZGP1 binds PIP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418850", "l": "Activation of Cdc42 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53261", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70950", "l": "L-tryptophan(in) <=> L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22084", "l": "(S)-2,3-diaminopropanoate + H(+) + H2O = 2 NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944229", "l": "Association of procollagen type IX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11898", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADH => 7alpha-hydroxycholesterol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.232", "l": "\"15-hydroxyicosatetraenoate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.295", "l": "\"2-methyl-6-phytyl-1,4-hydroquinone methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603905", "l": "Expression of NLRP3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37364", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 => 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39787", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15008", "l": "2-oxoglutarate + gibberellin A1 + O2 <=> CO2 + gibberellin A8 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928639", "l": "p-EFNB binds GRB4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68899", "l": "4-hydroxybenzoate + ATP + H(+) + NADPH <=> 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27560", "l": "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797974", "l": "LRRTMs bind NRXNs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730840", "l": "Activation of RAC1 by VAV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67545", "l": "(9Z)-tetradecenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863471", "l": "LDLR is bound by DAB2 and ARH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25309", "l": "7,8-dihydroneopterin + phosphate <=> 7,8-dihydroneopterin 3'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70203", "l": "N-methyldopaminechrome = 5,6-dihydroxyindole-N-methyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53661", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47679", "l": "ATP + N-acetyl-D-galactosamine <=> ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668253", "l": "Hyperactivation of factor X by FVIIIa:FIXa R384L (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21076", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 = CO2 + succinate + uridine", "d": [], "t": []}, {"i": "EC:1.14.11.3", "l": "\"pyrimidine-deoxynucleoside 2'-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708457", "l": "HM13 cleaves HMOX1 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917841", "l": "Acidification of Tf:TfR1 containing endosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990725", "l": "cord factor receptor activity", "d": ["Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70243", "l": "an N-acylsphing-4-enine + UDP-alpha-D-xylose = a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17519", "l": "a long-chain fatty acid + L-glutamate => H2O + N-(long-chain-fatty-acyl)-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44653", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164377", "l": "Activated Adenylate cyclase catalyses cAMP synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64353", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA => 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870465", "l": "RGGT binds the RAB-binding subunit (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419841", "l": "Light stimulates opsin receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64237", "l": "atrochrysone carboxyl-[ACP] + H2O => atrochrysone carboxylate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322427", "l": "Beta-catenin recruits CBP/p300 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13931", "l": "putrescine + urea => agmatine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69886", "l": "L-ascorbate(out) + 2 Na(+)(out) <=> L-ascorbate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000252", "l": "C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity", "d": ["Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64586", "l": "2-hydroxyethane-1-sulfonate(in) + Na(+)(in) => 2-hydroxyethane-1-sulfonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679044", "l": "FKBP1A binds sirolimus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.n3", "l": "\"curcumin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31567", "l": "bisphenol A + H(+) + NADH + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.51", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.16", "l": "\"neurolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8931981", "l": "RUNX1 binds ESR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47245", "l": "(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15168", "l": "H2O + O2 + sarcosine <=> glyoxylate + H2O2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.24", "l": "\"hydroxyacid-oxoacid transhydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68901", "l": "4-methoxybenzoate + ATP + H(+) + NADPH => 4-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102726", "l": "DIMBOA glucoside beta-D-glucosidase activity", "d": ["Catalysis of the reaction: (2R)-DIMBOA glucoside + H2O = H+ + DIMBOA + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109862", "l": "MAP2K2 phosphorylates MAPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64406", "l": "carnosine(in) + H(+)(in) => carnosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33441", "l": "glyoxylate + H(+) + H2O2 => glyoxal + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685201", "l": "CCDC59:TTF1 binds SFTPC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69127", "l": "Formation of the Flap Intermediate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043920", "l": "aminopropylagmatine ureohydrolase activity", "d": ["Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44983", "l": "(R)-carnitine + butanoyl-CoA <=> CoA + O-butanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9842649", "l": "Active LTK receptor binds PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59793", "l": "H2O + NADP(+) + yersinopine => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940554", "l": "MMP2 cleaves OPTC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9823934", "l": "OPTN binds TBK1 within the activated TLR4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55155", "l": "H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] <=> (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75985", "l": "(indol-3-yl)acetate(in) + a dicarboxylate(out) => (indol-3-yl)acetate(out) + a dicarboxylate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32590", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 <=> (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863008", "l": "Calpain activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299338", "l": "Activation of TRESK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67396", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61680", "l": "ATP + holo-[peptidyl-carrier protein] + L-cysteine = AMP + diphosphate + L-cysteinyl-[peptidyl-carrier protein]", "d": [], "t": []}, {"i": "EC:6.2.1.69", "l": "\"L-cysteine--[L-cysteinyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "43.495056689856582", "identifiers": [{"i": "GO:0038023", "l": "signaling receptor activity", "d": ["Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177284", "l": "PKA phosphorylates PDE4B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691621", "l": "C5 binds C5 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63394", "l": "AH2 + Fe(II)-heme i => A + Fe(II)-heme o + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018766", "l": "RHOU binds effectors at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56186", "l": "a globoside NOR1 + H(+) + UDP => a globoside Gb4Cer + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43389", "l": "1D-myo-inositol 3,4-bisphosphate + H2O => 1D-myo-inositol 3-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35677", "l": "3-oxohexadecasphinganine + CO2 + CoA => H(+) + L-serine + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21830", "l": "2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030848", "l": "threo-3-hydroxyaspartate ammonia-lyase activity", "d": ["Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH4 + oxaloacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67588", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43856", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.39", "l": "\"4-hydroxybenzoate polyprenyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60458", "l": "3',3'-cUAMP + 2 diphosphate => ATP + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794353", "l": "NRXNs binds MUNC18 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16276", "l": "an N-acylsphing-4-enine + CDP-choline <=> a sphingomyelin + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61257", "l": "H2O + L-cysteine + O2 => 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781905", "l": "ZRANB1 binds APC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357483", "l": "RAC1 binds PAK1-3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5444523", "l": "Formation of MSH1:PMS2 Complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36135", "l": "(2E)-hexadecenal + H2O + NAD(+) = (E)-hexadec-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51969", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59400", "l": "L-2-aminohexanoate = D-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59103", "l": "diglucosyl-enterobactin + UDP-alpha-D-glucose <=> H(+) + triglucosyl-enterobactin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015021", "l": "heparin-sulfate lyase activity", "d": ["Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38355", "l": "(R)-3-phenyllactoyl-CoA = (E)-cinnamoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37354", "l": "cytidine 2'-phosphate + H2O <=> cytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18974", "l": "2-oxoglutarate + deacetoxyvindoline + O2 => 4-O-deacetylvindoline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33033", "l": "D-sorbitol + NAD(+) => H(+) + keto-D-fructose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78804", "l": "a 2-iminocarboxylate + H2O => a 2-oxocarboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70979", "l": "MDH2 dimer dehydrogenates MAL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45158", "l": "3-oxopropanoate + CoA + H(+) => 3-oxopropanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49139", "l": "H(+) + L-methionyl-[protein] + NADPH + O2 <=> H2O + L-methionyl-S-oxide-[protein] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25176", "l": "H2O + N(omega)-methyl-L-arginine <=> L-citrulline + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362465", "l": "GHBP binds GHR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11828", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.58", "l": "\"RNA 2',3'-cyclic 3'-phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75007", "l": "H(+)(out) + VO(2+)(out) = H(+)(in) + VO(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37190", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate <=> 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050156", "l": "ornithine N-benzoyltransferase activity", "d": ["Catalysis of the reaction: L-ornithine + 2 benzoyl-CoA = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159733", "l": "Furin cleaves pro-factor X to factor X (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64685", "l": "L-threonyl-[protein] + UDP-alpha-D-glucose => 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975633", "l": "atROL binds to RBP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67296", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 = (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9709179", "l": "DPP4 binds DPP4 inhibitors (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852331", "l": "GTSE1 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57948", "l": "2-hydroxytoluene + H(+) + NADH + O2 = 3-methylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981621", "l": "Neuroglobin:oxygen dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13867", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34235", "l": "4-nitro-6-oxohepta-2,4-dienedioate = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71367", "l": "epiandrosterone 3-sulfate(out) + 2 Na(+)(out) = epiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202722", "l": "CD48 binds CD244 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418553", "l": "cAMP degradation by Phosphodiesterases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66185", "l": "3',5'-cyclic AMP(in) + ATP + H2O => 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68862", "l": "7beta-25-dihydroxycholesterol + NADP(+) => 7-oxo-25-hydroxycholesterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209828", "l": "Tryptophan is hydroxylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28011", "l": "propanoyl-CoA + succinate => propanoate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69380", "l": "2-hydroxy-4-methylpentanoate + O2 = 4-methyl-2-oxopentanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26033", "l": "3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18723", "l": "diphosphate + ent-13-epi-manoyl oxide => ent-8alpha-hydroxylabd-13-en-15-yl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69023", "l": "L-aspartate + NADPH + O2 <=> H2O + N-hydroxy-L-aspartate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39860", "l": "a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol => a triacyl-sn-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072591", "l": "citrate-L-glutamate ligase activity", "d": ["Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77584", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol => 1-octadecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74643", "l": "CMP-N-acetyl-beta-neuraminate(in) + UMP(out) = CMP-N-acetyl-beta-neuraminate(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23859", "l": "H(+) + Hg + NADP(+) <=> Hg(2+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096538", "l": "Defective LFNG does not transfer GlcNAc to Pre-NOTCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26186", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31971", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.146", "l": "\"taxoid 14beta-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51728", "l": "dihydroxyacetone phosphate + H2O = dihydroxyacetone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61910", "l": "2 AMP + asperphenamate + 2 diphosphate + H(+) => 2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15147", "l": "alpha,alpha-trehalose => D-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78244", "l": "D-asparagine + H2O + O2 => 2-oxosuccinamate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37708", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76230", "l": "(Z)-(indol-3-yl)-N-(sulfonatooxy)methanimidothioate <=> (indol-3-yl)acetonitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877902", "l": "Activated AR binds RUNX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22922", "l": "1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate => L-glutamine + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22122", "l": "GDP + phosphate + succinyl-CoA => CoA + GTP + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102848", "l": "1-18:2-2-18:2-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-18:2-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56610", "l": "L-serine + tetrahydrosulfopterin => 5,10-methylenetetrahydrosulfopterin + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60738", "l": "(2E,6E)-farnesoate + 2 H(+) + NADPH => (2E,6E)-farnesal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61533", "l": "ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27905", "l": "caffeine + H2O + ubiquinone-0 <=> 1,3,7-trimethylurate + ubiquinol-0", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40128", "l": "an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15733", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2", "d": [], "t": []}, {"i": "EC:1.17.99.3", "l": "\"3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45199", "l": "5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] <=> 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33780", "l": "6-kestotriose + sucrose => 6,6-kestotetraose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56029", "l": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37088", "l": "[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine => 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9834821", "l": "p-PRKRA dimer binds PKR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55401", "l": "7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) => archaeosine(15) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50824", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67597", "l": "heptadecasphing-4-enine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102274", "l": "glutathione S-conjugate carboxypeptidase activity", "d": ["Catalysis of the reaction: H2O + a glutathione-toxin conjugate = glycine + a [Glu-Cys]-S-conjugate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45071", "l": "(R)-carnitine + an acyl-CoA <=> CoA + O-acyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417908", "l": "P2RY1 binds ADP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71200", "l": "L-ornithine(in) => L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75784", "l": "ADP(in) => ADP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70191", "l": "ATP + NAD(+) = 3'-NADP(+) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798268", "l": "TP53 and E2F4 inhibit CDC25C expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28110", "l": "chloride + S-adenosyl-L-methionine = 5'-chloro-5'-deoxyadenosine + L-methionine", "d": [], "t": []}, {"i": "EC:2.5.1.94", "l": "\"adenosyl-chloride synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42340", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) = 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36487", "l": "agmatine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + N(1)-(3-aminopropyl)agmatine + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.5.1.104", "l": "\"N(1)-aminopropylagmatine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77608", "l": "Binding of A1CF to stem-looped RNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40648", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9623384", "l": "α1-agonists bind ADRA1A,B,D (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102653", "l": "gibberellin A51,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A51 + 2-oxoglutarate + O2 = H+ + gibberellin A51-catabolite + succinate + carbon dioxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76454", "l": "(E)-4-coumaroyl alcohol + A <=> (E)-4-coumaraldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427570", "l": "Group 3 - Selective Cl- transport (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036169", "l": "3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity", "d": ["Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2."], "t": []}, {"i": "REACT:R-HSA-2162195", "l": "COQ4 decarboxylates MHDB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16774", "l": "a ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose => a ganglioside GM1 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140598", "l": "lipoprotein carrier activity", "d": ["Binding to and carrying a lipoprotein between two different cellular locations by moving along with the target lipoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209573", "l": "p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40952", "l": "(2S)-2-acetamido-4-aminobutanoate + H2O => acetate + L-2,4-diaminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29812", "l": "ATP + H2O + thiamine(out) => ADP + H(+) + phosphate + thiamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12934", "l": "L-fuculose 1-phosphate => (S)-lactaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59387", "l": "2-oxoglutarate + 4-amino-L-phenylalanine <=> 3-(4-aminophenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201717", "l": "CSNK2-mediated phosphorylation of DVL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "58.72191752962285", "identifiers": [{"i": "GO:0004497", "l": "monooxygenase activity", "d": ["Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167415", "l": "G-protein alpha subunit is inactivated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38434", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O <=> (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27488", "l": "allantoate + 2 H(+) + H2O <=> (S)-2-ureidoglycine + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15839", "l": "N-methyl-L-glutamate + NH4(+) => L-glutamate + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48406", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein] => apo-[aryl-carrier protein] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34575", "l": "2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone", "d": [], "t": []}, {"i": "EC:1.14.19.8", "l": "\"pentalenolactone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429860", "l": "DCP1-DCP2 complex decaps mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64857", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + phomopsene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29843", "l": "ATP + CoA + propanoate = ADP + phosphate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173680", "l": "Activation of C5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25839", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O <=> 5-deoxy-D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418850", "l": "Activation of Cdc42 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937177", "l": "AHR:TCDD binds ARNT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015220", "l": "choline transmembrane transporter activity", "d": ["Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944215", "l": "Association of procollagen type XX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48536", "l": "1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O = 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15452", "l": "homogentisate + O2 <=> 4-maleylacetoacetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032523", "l": "silicon efflux transmembrane transporter activity", "d": ["Enables the transfer of silicon from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53763", "l": "allocholate + deoxycholoyl-CoA <=> allocholoyl-CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-921155", "l": "p-STAT5 dissociates from the receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23465", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78713", "l": "aldehydo-D-glucuronate + alpha-D-glucose 1-phosphate => 3-O-beta-D-glucosyl-D-glucuronate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855375", "l": "PTPN22 dissociates from CSK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70865", "l": "L-glutamine(in) + L-threonine(out) + Na(+)(in) => L-glutamine(out) + L-threonine(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.18", "l": "\"carboxypeptidase T\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64354", "l": "2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA => 3 H(+) + hexanoyl-CoA + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67421", "l": "a glycerophospholipid + H2O => a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21984", "l": "3'-phosphoadenylyl sulfate + choline = adenosine 3',5'-bisphosphate + choline sulfate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.6", "l": "\"choline sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8963915", "l": "1,25(OH)2D binds VDR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76456", "l": "O-atom dealkylation of dextromethorphan (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507871", "l": "Aquaporins passively transport glycerol out of cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786421", "l": "CHIA hydrolyses chitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76902", "l": "cyclohexylamine + H2O + NADP(+) <=> cyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33740", "l": "2 H(+) + hexadecanoate + NADH => H2O + hexadecanal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848414", "l": "Activated PTK6 binds CDKN1B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60757", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone => cinerin I + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16440", "l": "glutathione + RX <=> a halide anion + an S-substituted glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.-", "l": "\"Enzymes altering polypeptide conformation or assembly\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73559", "l": "dGTP(out) + UTP(in) = dGTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0070891", "l": "lipoteichoic acid binding", "d": ["Binding to lipoteichoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200396", "l": "Creatine transport across the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421831", "l": "trans-Golgi Network Coat Assembly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18722", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate => diphosphate + ent-13-epi-manoyl oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73083", "l": "chrysoeriol + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + velutin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67838", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990593", "l": "nascent polypeptide-associated complex binding", "d": ["Binding to nascent polypeptide-associated complex, a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53858", "l": "3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH => NADP(+) + ursocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008459", "l": "chondroitin 6-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102858", "l": "1-18:2-2-18:3-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:3-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950456", "l": "IL12B dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73410", "l": "(S,S)-tartrate(in) + sulfate(out) <=> (S,S)-tartrate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34421", "l": "(+)-pinoresinol + H(+) + NADPH => (+)-lariciresinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62487", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928644", "l": "EPHB binds ITSN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654571", "l": "Activated FGFR1 binds FRS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9650165", "l": "ASIC trimers bind H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54333", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102933", "l": "GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity", "d": ["Catalysis of the reaction: GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate = GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45381", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862300", "l": "LYZ binds bacterial peptidoglycan (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27593", "l": "(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58130", "l": "AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374680", "l": "L1 trans-homophilic interaction (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10369", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473594", "l": "Collagen type II degradation by MMP15 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53728", "l": "H2O + N-acetyl-D-muramate 6-phosphate = N-acetyl-D-muramate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.105", "l": "\"N-acetyl-D-muramate 6-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296043", "l": "Activation of HCN channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36934", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69595", "l": "CMP + inosine <=> cytidine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.115", "l": "\"infectious pancreatic necrosis birnavirus Vp4 peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76904", "l": "(1S)-2-methyl-cyclohexylamine + H2O + NAD(+) => 2-methylcyclohexanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44519", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49944", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate = (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1878002", "l": "XYLTs transfer Xyl to core protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69640", "l": "H2O + phlorizin => beta-D-glucose + phloretin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391158", "l": "SIRP alpha binds CD47 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38167", "l": "hexadecan-1-ol + hexadecanoyl-CoA = CoA + hexadecanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791122", "l": "Expression of PDIA5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874789", "l": "TFAP2C homodimer binds the EGFR gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72098", "l": "(S)-carnitine(out) + Na(+)(out) <=> (S)-carnitine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30429", "l": "(+)-germacrene D + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.179", "l": "\"gellan tetrasaccharide unsaturated glucuronosyl hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781941", "l": "WNTs are secreted in exosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62267", "l": "hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) <=> hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0005160", "l": "transforming growth factor beta receptor binding", "d": ["Binding to a transforming growth factor beta receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034076", "l": "cucurbitadienol synthase activity", "d": ["Catalysis of the reaction: oxidosqualene = cucurbitadienol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36938", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902314", "l": "hydroquinone binding", "d": ["Binding to hydroquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017098", "l": "sulfonylurea receptor binding", "d": ["Binding to a sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42622", "l": "(Z)-2-methylaminoacrylate + CO2 + NH4(+) => (Z)-2-methylureidoacrylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9619756", "l": "NR1H2 binds ABCA1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78805", "l": "a 2-oxocarboxylate + NH4(+) => a 2-iminocarboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20669", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52735", "l": "3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate <=> adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70795", "l": "H(+)(in) + L-lysine(out) = H(+)(out) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33099", "l": "acetyl-CoA + spermine = CoA + H(+) + N(1)-acetylspermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193695", "l": "IRAK interacts with TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050604", "l": "taxadiene 5-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + taxa-4,11-diene = A + H2O + taxa-4(20),11-dien-5alpha-ol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29918", "l": "L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39319", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47380", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83677", "l": "C4 deamination of cytidine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54344", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29433", "l": "ADP + diphosphate => ATP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.29", "l": "\"pyranose dehydrogenase (acceptor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9690494", "l": "RHOB translocates to the endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.5.1.-", "l": "\"Carbon-halide lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029454", "l": "Autophosphorylation of PAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52676", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine", "d": [], "t": []}, {"i": "EC:3.5.1.132", "l": "\"[amino group carrier protein]-ornithine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036467", "l": "5-hydroxy-L-tryptophan decarboxylase activity", "d": ["Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin."], "t": []}, {"i": "RHEA:18533", "l": "5-hydroxy-L-tryptophan + H(+) = CO2 + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31969", "l": "ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73176", "l": "ADP(in) + FMN(out) => ADP(out) + FMN(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32344", "l": "(+)-thujan-3-ol + NAD(+) => (+)-thujan-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66548", "l": "3'-phosphoadenylyl sulfate + 4-nitrophenol = 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034824", "l": "citronellyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: citronellyl-CoA + NAD+ = cis-geranyl-CoA + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75940", "l": "4-aminobutanoate + L-arginine => 4-guanidinobutanoate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15518", "l": "H2O + N(2),6-disulfo-D-glucosamine => H(+) + N-sulfo-D-glucosamine + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034835", "l": "2-mercaptobenzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731708", "l": "nsp10:nsp14 binds to ExoN inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28015", "l": "S-adenosyl-L-methionine + thiocyanate => methyl thiocyanate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68810", "l": "alpha-D-glucose + D-fructose => 6-O-alpha-D-glucopyranosyl-D-fructose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53636", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36775", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = alpha-L-Fuc-(1->2)-[alpha-D-Gal-(1->3)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.309", "l": "\"UDP-Gal:alpha-L-Fuc-1,2-beta-Gal-1,3-alpha-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31052", "l": "(3R)-beta-leucine + H2O + NAD(+) => 4-methyl-3-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74276", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A => a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16060", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27570", "l": "ATP + D-glycero-alpha-D-manno-heptose 7-phosphate = ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.168", "l": "\"D-glycero-alpha-D-manno-heptose-7-phosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878117", "l": "RUNX3 binds ZFHX3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21968", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.4", "l": "\"3-dehydroquinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424476", "l": "Activation of RAC1 by VAV2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57149", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796300", "l": "Expression of NOTO in axial mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57872", "l": "(E)-2,4-dihydroxycinnamoyl-CoA = CoA + umbelliferone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9861667", "l": "DLAT trimer transfers acetyl to CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57915", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) <=> H(+) + L-glutaminyl-tRNA(Gln) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19752", "l": "[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705729", "l": "SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38681", "l": "ADP + H(+) + phosphate + sphinganine(out) => ATP + H2O + sphinganine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44005", "l": "3-methyl fatty acid + ATP + CoA => a 3-methyl fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46950", "l": "N(7)-methyl-GTP + S-adenosyl-L-homocysteine => GTP + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710101", "l": "CASP4, CASP5 cleave GSDMD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.244991688848543", "identifiers": [{"i": "GO:0016595", "l": "glutamate binding", "d": ["Binding to glutamate, the anion of 2-aminopentanedioic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.742650533605641", "identifiers": [{"i": "GO:0016462", "l": "pyrophosphatase activity", "d": ["Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups."], "t": []}, {"i": "REACT:R-HSA-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420265", "l": "AMY1-3 bind IAPP(34-70) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62190", "l": "diphosphate + syn-isopimara-7,15-diene => 9alpha-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112435", "l": "Formation of Elongin BC complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76082", "l": "a dicarboxylate(in) + L-sepiapterin(out) <=> a dicarboxylate(out) + L-sepiapterin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40928", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690740", "l": "CD22 binds B-cell receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76145", "l": "ervincine + H(+) + S-adenosyl-L-homocysteine => picrinine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52865", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196964", "l": "RFK:Mg2+ phosphorylates RIB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73799", "l": "dimethylallyl diphosphate + isoechinulin A = dehydroechinulin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22812", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methenyltetrahydrofolate + NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.5", "l": "\"methylenetetrahydrofolate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70361", "l": "CoA + H(+) + N-acyl-3-oxosphinganine => 3-oxosphinganine + a fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24581", "l": "D-sorbitol 6-phosphate + H2O => D-sorbitol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032542", "l": "sulfiredoxin activity", "d": ["Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018618", "l": "anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity", "d": ["Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27581", "l": "(R)-N-tert-butylpiperazine-2-carboxamide + H2O <=> (R)-piperazine-2-carboxylate + tert-butylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19719", "l": "2-phenylethylamine + CO2 => H(+) + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50319", "l": "ethyl octadecanoate + H2O <=> ethanol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759158", "l": "SQSTM1 oligomerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.6", "l": "\"ABC-type lipid A-core oligosaccharide transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15275", "l": "3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034025", "l": "D-aspartate ligase activity", "d": ["Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972977", "l": "POU5F1 (OCT4), SOX2, NANOG bind the DKK1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11882", "l": "6-hydroxypseudooxynicotine + H2O2 => (S)-6-hydroxynicotine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33889", "l": "(-)-matairesinol + 2 H(+) + 2 NADH => (-)-secoisolariciresinol + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183052", "l": "CBL binds to GRB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57755", "l": "2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062154", "l": "N6-methyl-AMP deaminase activity", "d": ["Catalysis of the reaction: H+ + H2O + N6-methyl-AMP = IMP + methylamine. Can also use N6-methyl-dAMP as a substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25586", "l": "beta-L-rhamnose => alpha-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58777", "l": "NADP(+) + pyridine 3-methanol => H(+) + NADPH + pyridine-3-carbaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9824882", "l": "IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75991", "l": "a dicarboxylate(in) + N-benzoylglycine(out) = a dicarboxylate(out) + N-benzoylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74118", "l": "an anthocyanidin + UDP-alpha-D-galactose <=> an anthocyanidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28975", "l": "H(+)(out) + L-asparagine(in) = H(+)(in) + L-asparagine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800797", "l": "The PIDDosome activates CASP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015614", "l": "ABC-type D-xylose transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) = ADP + phosphate + D-xylose(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77077", "l": "Capping complex formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57808", "l": "1-chloro-3-nitrobenzene + NADH + O2 = 3-chlorocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928604", "l": "SFKs phosphorylate VAV2,3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72315", "l": "glutathione(in) + leukotriene C4(out) = glutathione(out) + leukotriene C4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66112", "l": "2-oxobutanoate + L-tyrosine = (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39039", "l": "an omega-oxo fatty acid + H2O + NAD(+) = a dicarboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671702", "l": "AP1G2 binds HGS and CHMP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-350598", "l": "Arginine<=>Agmatine+CO2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60997", "l": "H2O + L-leucine + O2 => 4-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64389", "l": "4 A + sn-3-O-phytanylglycerol 1-phosphate => 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78978", "l": "(R)-5-phosphomevalonate <=> (2E)-3-methyl-5-phosphooxypent-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0099510", "l": "calcium ion binding involved in regulation of cytosolic calcium ion concentration", "d": ["The directed change of cytosolic calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in cytosolic calcium concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788623", "l": "p-Y-STATs translocate to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18844", "l": "(R)-glycerate + NADP(+) <=> 2-hydroxy-3-oxopropanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50126", "l": "8-oxoresolvin D1 + H(+) + NADH => NAD(+) + resolvin D1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034935", "l": "tetrachlorobenzene dioxygenase activity", "d": ["Catalysis of the reaction: 2,4-dichlorotoluene + NADH + H+ + O2 = 4,6-dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177923", "l": "Sustained activation of SRC kinase by SHP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72754", "l": "H2O + ochratoxin A <=> L-phenylalanine + ochratoxin alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844425", "l": "SMAD1:SMAD4 trimer binds ZNF423 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190065", "l": "Activated TrkA receptor internalizes to endosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21367", "l": "H2O + N-(6-aminohexanoyl)-6-aminohexanoate <=> 2 6-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227885", "l": "TBK1/IKK epsilon bind to TANK:TRAF3/TRAF6 complex followed by their activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202731", "l": "JAM3 dimerises (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17877", "l": "a catechol + S-adenosyl-L-methionine = a guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.6", "l": "\"catechol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69609", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin] => acetyl-CoA + N-terminal L-methionyl-[tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797810", "l": "PTPRD binds IL1RAPL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730903", "l": "Oligomerization of TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56498", "l": "gypsogenate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => gypsogenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12984", "l": "H2O + O2 + S-sulfanylglutathione <=> glutathione + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140355", "l": "cargo receptor ligand activity", "d": ["The activity of a gene product that interacts with a cargo receptor and initiates endocytosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72756", "l": "3 ATP => 3',3',3'-c-tri-AMP + 3 diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12105", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP => 7,8-dihydrofolate + dTMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333678", "l": "CPNEs bind PL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60624", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O = 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50459", "l": "prostaglandin H3 <=> prostaglandin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55235", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36520", "l": "H(+) + hexacosanoyl-CoA + malonyl-CoA => 3-oxooctacosanyol-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15568", "l": "an N-acyl-L-amino acid + H2O <=> a carboxylate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204169", "l": "PDP1,2 dephosphorylate p-lipo-PDH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70953", "l": "3-hydroxypyruvate + H2O2 + NH4(+) => D-serine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55413", "l": "[phosphate](n) + GTP => [phosphate](n+1) + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77908", "l": "H2O + 2 O2 + sym-homospermidine => 1-formylpyrrolizidine + 2 H2O2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875451", "l": "MET phosphorylates CBL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35863", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952442", "l": "SPP1 gene expression is stimulated by RUNX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38175", "l": "all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29425", "l": "ADP + H(+) + triphosphate => ATP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52560", "l": "2-dehydro-D-erythronate = 3-dehydro-D-erythronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.97", "l": "\"endo-alpha-N-acetylgalactosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031822", "l": "type 1B serotonin receptor binding", "d": ["Binding to a type 1B serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46688", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + A = 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62007", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42865", "l": "norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + norspermine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.117", "l": "\"6-aminohexanoate-oligomer endohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1362416", "l": "Frataxin binds iron (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534359", "l": "CatSper Channel Mediated Calcium Transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45627", "l": "ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine <=> AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19671", "l": "GDP + H(+) + phosphate => GTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781941", "l": "WNTs are secreted in exosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16543", "l": "(3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin => 9-cis-violaxanthin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35496", "l": "H2O + N-(4-aminobenzoyl)-L-glutamate => 4-aminobenzoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43366", "l": "beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP => L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10219", "l": "[DNA-directed RNA polymerase] + ATP <=> ADP + H(+) + phospho-[DNA-directed RNA polymerase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69837", "l": "(22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => campesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395517", "l": "NADPH transfers electrons to FDXR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74619", "l": "CMP(in) + UMP(out) = CMP(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24356", "l": "a 1-acyl-sn-glycero-3-phosphocholine = a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}, {"i": "EC:5.4.1.1", "l": "\"lysolecithin acylmutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.23", "l": "\"acylglycerol lipase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75655", "l": "(9Z)-octadecenoate + O2 = (8R)-hydroperoxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75172", "l": "Formation of RAD50:MRE11 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810376", "l": "ING2 binds PI5P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.30", "l": "\"1,3-beta-oligoglucan phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052732", "l": "phosphoethanolamine phosphatase activity", "d": ["Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33754", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166387", "l": "The FA anion diffuses away laterally from UCP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.2.2", "l": "\"adenylosuccinate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40103", "l": "H2O + propanoyl-CoA = CoA + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52372", "l": "17beta-estradiol + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64895", "l": "holo-[ACP] + tetradecanoyl-AMP <=> AMP + H(+) + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63678", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH => CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013024", "l": "RHOB binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77671", "l": "a globoside GalGb4Cer (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a globoside MSGG (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49619", "l": "2-hydroxy-2-methylpropanal + H2O + NAD(+) <=> 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14061", "l": "H2O + N-(carboxymethyl)-D-alanine + NAD(+) = glycine + H(+) + NADH + pyruvate", "d": [], "t": []}, {"i": "EC:1.5.1.22", "l": "\"strombine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592387", "l": "Fibulin binds elastic fibres (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46505", "l": "dodecanoyl-AMP + holo-[ACP] => AMP + dodecanoyl-[ACP] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17818", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H(+) + holo-[ACP] + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174058", "l": "Degradation of multiubiquitinated Cdh1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018826", "l": "RHOT2 hydrolyzes GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67566", "l": "adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + chenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388833", "l": "Phosphorylation of CTLA-4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18006", "l": "D-threitol + NADP(+) => D-erythrulose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928624", "l": "EPHBs bind EFNBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32859", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35842", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA <=> a cardiolipin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54112", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + selina-4(15),7(11)-diene", "d": [], "t": []}, {"i": "EC:4.2.3.181", "l": "\"selina-4(15),7(11)-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018798", "l": "RHOV binds GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39066", "l": "NADP(+) + scyllo-inositol <=> H(+) + NADPH + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45655", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9010872", "l": "SLIT2 binds Dystroglycan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3857336", "l": "CEBPB homodimerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689649", "l": "BAP1 binds BRCA1:BARD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47365", "l": "a dodecanoate ester + H2O => an aliphatic alcohol + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018594", "l": "MECP2 binds LBR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.42", "l": "\"atrolysin C\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23665", "l": "A + a (2R)-2-hydroxycarboxylate => a 2-oxocarboxylate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9615348", "l": "AGT(34-41) binds to AGTR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59537", "l": "ATP + butanoyl-CoA + hydrogencarbonate => (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139895", "l": "tBID activates BAK protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218829", "l": "VEGF induces CDC42 activation by unknown mechanism (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64045", "l": "(13Z)-docosenoyl-CoA + sphing-4-enine => CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32118", "l": "2-oxoglutarate + DIBOA beta-D-glucoside + O2 <=> CO2 + succinate + TRIBOA beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665408", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51911", "l": "dATP + H2O <=> dADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37784", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9761474", "l": "AMOT-2 binds CDH11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48017", "l": "4-methyl-5-nitrocatechol + NADH + O2 => 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004018", "l": "N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity", "d": ["Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29179", "l": "a menaquinol + 2 O2 = a menaquinone + 2 H(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835009", "l": "PRKN binds p-S-Ub:MOM proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018747", "l": "RHOQ GEFs activate RHOQ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25153", "l": "2-oxoglutarate + L-phenylalanine => 3-phenylpyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49180", "l": "a bacteriochlorophyllide d + S-adenosyl-L-methionine = a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.333", "l": "\"bacteriochlorophyllide d C-20 methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.22", "l": "\"rRNA N-glycosylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73489", "l": "a carboxylate(out) + orotate(in) => a carboxylate(in) + orotate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614544", "l": "Sulfite is oxidized to sulfate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.59", "l": "\"long-chain fatty acid adenylase/transferase FadD26\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9861667", "l": "DLAT trimer transfers acetyl to CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694527", "l": "Loss of SAR1B GTPase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866277", "l": "AP-2 directly binds some endocytic cargo (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390438", "l": "FAR2 reduces PalmCoA to HXOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656244", "l": "DRD2 binds DA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018794", "l": "RHOV binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786101", "l": "IL4 binds IL4R:JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22190", "l": "a (2S)-2-hydroxycarboxylate + a halide anion + H(+) => an (R)-2-haloacid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20404", "l": "a beta-lactam + H2O <=> a substituted beta-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047327", "l": "glycerol-3-phosphate-glucose phosphotransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + D-glucose = D-glucose 6-phosphate + glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432956", "l": "BP230 is recruited to the hemidesmosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024161", "l": "FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193695", "l": "IRAK interacts with TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47631", "l": "glyoxylate + H2O + propanoyl-CoA <=> 3-methylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.162", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936731", "l": "Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42222", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694467", "l": "Spike protein forms a homotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38410", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0000703", "l": "oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity", "d": ["Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52049", "l": "9-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21227", "l": "CDP-choline + sphing-4-enine <=> CMP + H(+) + sphing-4-enine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33875", "l": "cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948034", "l": "FGR binds LDL:LRP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.6", "l": "\"DNA ligase (ATP or NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174171", "l": "Association of Cyclin A with the APC/C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65588", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51195", "l": "(R)-2-hydroxyglutarate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48317", "l": "a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate => a ganglioside GD1alpha + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669012", "l": "EDA binds EDAR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.100", "l": "\"2,1-fructan:2,1-fructan 1-fructosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168459", "l": "Lyn activates ERK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11824", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate", "d": [], "t": []}, {"i": "EC:2.1.2.11", "l": "\"3-methyl-2-oxobutanoate hydroxymethyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76121", "l": "a dicarboxylate(out) + prostaglandin F2alpha(in) => a dicarboxylate(in) + prostaglandin F2alpha(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65765", "l": "a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O => (2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56329", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + H2O => 5'-triphosphoadenylyl-(2'->5')-adenosine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55566", "l": "4-hydoxytryptamine 4-phosphate + ADP + H(+) => 4-hydroxytryptamine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41954", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate => 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20091", "l": "CoA + H(+) + N-acetyl-L-leucine => acetyl-CoA + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424484", "l": "Phosphorylation of BTK by p-SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69127", "l": "Formation of the Flap Intermediate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57432", "l": "3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] = 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38282", "l": "(3R)-citramalate + succinyl-CoA <=> (3R)-citramalyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050541", "l": "beta,beta-carotene-9',10'-dioxygenase activity", "d": ["Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51992", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.43", "l": "\"(methylsulfanyl)alkanaldoxime N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34494", "l": "H2O + UDP-N,N'-diacetylbacillosamine <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57222", "l": "N(2)-(1-hydroxy-2-oxopropyl)-GTP => GTP + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981606", "l": "Myoglobin binds oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58572", "l": "O-acetyl-15alpha-stemmadenine + O2 = H2O2 + precondylocarpine acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47991", "l": "2-dehydro-3-deoxy-L-galactonate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19602", "l": "H(+) + NADH + O2 + orcinol => 2,3,5-trihydroxytoluene + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59314", "l": "D-galactono-1,5-lactone + H2O2 => D-galactose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18317", "l": "an L-alpha-amino acid = a D-alpha-amino acid", "d": [], "t": []}, {"i": "EC:5.1.1.10", "l": "\"amino-acid racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43917", "l": "(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875523", "l": "MET binds TNS3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51574", "l": "(25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009374", "l": "biotin binding", "d": ["Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78246", "l": "D-asparagine + H2O + O2 <=> 2-oxosuccinamate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14218", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] => [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102088", "l": "N-(4-hydroxybenzoyl)-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoic acid + L-glutamate + ATP = H+ + N-(4-hydroxybenzoyl)-L-glutamate + AMP + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944254", "l": "Association of procollagen type XXVI (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27888", "l": "3'-AMP + H(+) => 2',3'-cyclophospho-AMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55324", "l": "11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51908", "l": "dATP + H2O = dADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19613", "l": "dimethyl sulfide + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + trimethylsulfonium", "d": [], "t": []}, {"i": "EC:2.1.1.96", "l": "\"thioether S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.247", "l": "\"codeinone reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25715", "l": "N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42518", "l": "H(+) + L-gulonate => H2O + L-gulono-1,4-lactone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14712", "l": "a 3-oxo-Delta(5)-steroid <=> a 3-oxo-Delta(4)-steroid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372697", "l": "Crk binding to p130cas (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014449", "l": "RHOG binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672175", "l": "Autophosphorylation of PDGFR mutant dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803063", "l": "RNASEs bind bacterial LPS, PGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634228", "l": "TRAF1 is cleaved by caspases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69460", "l": "[thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine = [thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46048", "l": "D-galactosamine 6-phosphate = alpha-D-galactosamine 1-phosphate", "d": [], "t": []}, {"i": "EC:5.4.2.13", "l": "\"phosphogalactosamine mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665705", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77480", "l": "hexan-2-one + hydrogen cyanide => (2S)-2-hydroxy-2-methylhexanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14345", "l": "H(+) + L-tyrosine = CO2 + tyramine", "d": [], "t": []}, {"i": "EC:4.1.1.25", "l": "\"tyrosine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442913", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65395", "l": "4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH <=> (8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64514", "l": "6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine => (3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39736", "l": "3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25754", "l": "N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57348", "l": "3-hydroxy-4-methyl-L-kynurenine + H2O = 3-hydroxy-4-methylanthranilate + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35062", "l": "chloramphenicol(in) + H(+)(out) <=> chloramphenicol(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-593685", "l": "Netrin-4 binds DCC/UNC5A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22403", "l": "androstan-3alpha,17beta-diol + NAD(+) <=> 17beta-hydroxyandrostanone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75508", "l": "n H(+)(out) + taurocholate(out) => n H(+)(in) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33617", "l": "AMP + diphosphate + octadecanoyl-CoA => ATP + CoA + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018747", "l": "RHOQ GEFs activate RHOQ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71710", "l": "H(+)(out) + L-phenylalanyl-L-phenylalanine(out) <=> H(+)(in) + L-phenylalanyl-L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050733", "l": "RS domain binding", "d": ["Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42946", "l": "5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(40) in tRNA precursor + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.78", "l": "\"arogenate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17479", "l": "CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine => precorrin-6B + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64079", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 <=> 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77146", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O <=> 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74796", "l": "N-methyl-(R)-salsolinol(in) => N-methyl-(R)-salsolinol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54046", "l": "7-epi-alpha-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629918", "l": "NEIL1 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10304", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.40", "l": "\"acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618407", "l": "NR1H2,3 binds the ARL4C gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.35", "l": "\"phenol beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700156", "l": "Active ALK dimer binds IRS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635843", "l": "GLI translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26385", "l": "all-trans-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal", "d": [], "t": []}, {"i": "EC:1.13.11.75", "l": "\"all-trans-8'-apo-beta-carotenal 15,15'-oxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14487", "l": "10-epi-juneol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68057", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O => a 3'-end 3'-phospho-ribonucleotide-RNA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036046", "l": "Defective IDS does not hydrolyse Heparan sulfate chain(5) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140773", "l": "NAD-dependent protein demyristoylase activity", "d": ["Catalysis of the reaction: N6-tetradecanoyl-L-lysyl-[protein] + NAD+ + H2O = tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:70567", "l": "H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31750", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) <=> 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51004", "l": "a primary alcohol + 2 Fe(III)-[cytochrome cL] = an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75112", "l": "32-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31725", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029591", "l": "Expression of ABCG8 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58812", "l": "ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate = AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": [], "t": []}, {"i": "EC:5.1.1.23", "l": "\"UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34527", "l": "L-phenylalanine = (S)-3-amino-3-phenylpropanoate", "d": [], "t": []}, {"i": "EC:5.4.3.11", "l": "\"phenylalanine aminomutase (D-beta-phenylalanine forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55120", "l": "4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55025", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49837", "l": "(5E)-tetradecenoyl-CoA + (R)-carnitine => (5E)-tetradecenoyl-(R)-carnitine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687099", "l": "p-S857 NCOA3:ETV4 bind MMP2 and MMP10 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44691", "l": "a 2-acylglycerol + H2O <=> a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0004985", "l": "G protein-coupled opioid receptor activity", "d": ["Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34248", "l": "1-deoxymethyl-sphinganine + NADP(+) => 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168888", "l": "Alpha1-Microglobulin binds heme (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047915", "l": "ganglioside galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59764", "l": "L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12350", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate => (S)-muconolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130731", "l": "Formation of COPII vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174157", "l": "Degradation of multiubiquitinated Cyclin B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052775", "l": "endo-1,3-alpha-L-rhamnosidase activity", "d": ["Catalysis of the reaction: R1-L-rhamnose-(1->3)-alpha-L-rhamnose-R2 + H2O = R1-L-rhamnose + L-rhamnose-R2. This reaction is the hydrolysis of an alpha-(1->3) linkage between two rhamnose residues in a polysaccharide chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761854", "l": "NFE2L2-dependent ME1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59457", "l": "NADP(+) + tetradecan-1-ol => H(+) + NADPH + tetradecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56267", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004575", "l": "sucrose alpha-glucosidase activity", "d": ["Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52084", "l": "13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67790", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin => 2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731034", "l": "SARS-CoV-1 3a tetramer binds to CAV1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20652", "l": "23,24-dihydrocucurbitacin B + NADP(+) <=> cucurbitacin B + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57669", "l": "alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21437", "l": "[translation elongation factor 2] + ATP => [translation elongation factor 2]-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684301", "l": "mRNA1 is translated to pp1a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22574", "l": "AH2 + formaldehyde + L-glutamate => A + H2O + N-methyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24509", "l": "NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41228", "l": "(S)-4-hydroxymandelate + O2 => 4-hydroxyphenylglyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10937", "l": "6-decylubiquinone + 2 thiosulfate => 6-decylubiquinol + tetrathionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29672", "l": "Ca(2+)(in) => Ca(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70231", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) = (S)-2-benzoylsuccinyl-CoA + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.429", "l": "\"(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0070854", "l": "myosin VI heavy chain binding", "d": ["Binding to a heavy chain of a myosin VI complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13885", "l": "H2O + stipitatonate = CO2 + stipitatate", "d": [], "t": []}, {"i": "EC:4.1.1.60", "l": "\"stipitatonate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9608288", "l": "Defective MUTYH mutants do not bind adenine mispaired with 8-oxoguanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340214", "l": "CYGB binds O2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53421", "l": "8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine => H(+) + roseoflavin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32384", "l": "(1S,2S,4R)-limonene-1,2-diol + NAD(+) => (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39713", "l": "2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) => O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61508", "l": "peonidin + UDP-alpha-D-glucose = peonidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68522", "l": "beta-acoradiene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58023", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) <=> eupatolide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43096", "l": "guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.209", "l": "\"23S rRNA (guanine(2535)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0160102", "l": "tRNA (guanine(10)-N2)-methyltransferase activity", "d": ["Catalysis of the reaction: guanosine(10) in tRNA + S-adenosyl-L-methionine = H+ + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036317", "l": "tyrosyl-RNA phosphodiesterase activity", "d": ["Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433374", "l": "Processing of SCF isoform 1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534388", "l": "Progesterone Activation Of CatSper (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63964", "l": "sphinga-4E,14Z-dienine-1-phosphate = (2E,12Z)-hexadecadienal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180001", "l": "cyclic-di-AMP binding", "d": ["Binding to a cyclic di-AMP nucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24919", "l": "L-homoserine = 2-aminobut-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373177", "l": "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14009", "l": "2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.67", "l": "\"chrysanthemyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40656", "l": "(R)-malate + succinyl-CoA => (R)-malyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40900", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32737", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36815", "l": "dTDP-alpha-D-fucose = dTDP-alpha-D-fucofuranose", "d": [], "t": []}, {"i": "EC:5.4.99.59", "l": "\"dTDP-fucopyranose mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68380", "l": "3-hydroxypyruvate + L-asparagine = 2-oxosuccinamate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75798", "l": "Na(+)(out) + nicotinate(out) <=> Na(+)(in) + nicotinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030977", "l": "taurine binding", "d": ["Binding to taurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5620975", "l": "MLKL binds PIPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77194", "l": "an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64105", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] => 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42925", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78953", "l": "a 1,2-diacyl-sn-glycerol + H(+) + phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20250", "l": "L-alanine => D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46195", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18172", "l": "4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371435", "l": "Constitutive phosphorylation by GSK3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68848", "l": "(2Z,6E)-farnesyl diphosphate = diphosphate + gamma-cadinene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13769", "l": "glycerol + NAD(+) = dihydroxyacetone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.6", "l": "\"glycerol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68733", "l": "ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172126", "l": "DAP12 interacts with NKG2C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564169", "l": "Collagen type VIII degradation by MMP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36474", "l": "3,4,5-trihydroxybenzoate(out) + H(+)(out) <=> 3,4,5-trihydroxybenzoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102974", "l": "hydroxyversicolorone reductase activity", "d": ["Catalysis of the reaction: versicolorone + NADP = hydroxyversicolorone + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.36", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018784", "l": "(S)-2-haloacid dehalogenase activity", "d": ["Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36694", "l": "octadecanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41597", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH => (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35747", "l": "(2E,6E)-farnesyl diphosphate = 7-epizingiberene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.142", "l": "\"7-epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912734", "l": "CBL:CRKL binds RAPGEF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097265", "l": "5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity", "d": ["Catalysis of the reaction: 5-HETE + NADP+ = 5-oxo-ETE + NADPH + H+."], "t": []}, {"i": "REACT:R-HSA-2161776", "l": "5S-HETE is oxidised to 5-oxoETE by 5-HEDH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63509", "l": "a 1,2-saturated fatty acid + O2 => a (2R)-2-hydroperoxy fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202714", "l": "CD58 binds CD2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43029", "l": "L-cysteate => 2-aminoprop-2-enoate + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428231", "l": "ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41619", "l": "D-ribose 2,5-bisphosphate + H2O <=> D-ribose 5-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29322", "l": "H2O + sn-glycero-3-phosphoethanolamine <=> ethanolamine + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63451", "l": "(2-aminoethyl)phosphonate + CTP <=> CMP-(2-aminoethyl)phosphonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74365", "l": "coproporphyrin III(in) => coproporphyrin III(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3222093", "l": "BRD7 binds TP53 and EP300 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46194", "l": "3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74566", "l": "aldosterone hemiacetal + UDP-alpha-D-glucuronate <=> aldosterone hemiacetal 18-beta-glucuronide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102326", "l": "2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H2O = 2,3-dihydroxybenzoate + 2-oxopent-4-enoate + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10178", "l": "(R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH => (2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218805", "l": "PKC autophosphorylates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809254", "l": "MTMR8 binds MTMR9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570528", "l": "SUMOylation of XPC with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76994", "l": "H(+) + NAD(+) + reduced 2[4Fe-4S]-[ferredoxin] <=> NADH + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21975", "l": "precorrin-1 + S-adenosyl-L-methionine <=> precorrin-2 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50659", "l": "3-(2-methylsulfanyl)ethylmalate <=> 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59650", "l": "D-xylotrionate + H(+) => D-xylotriono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17908", "l": "(R)-glycerate + NAD(+) <=> 3-hydroxypyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16076", "l": "2,2-dialkylglycine + H(+) + pyruvate <=> CO2 + dialkyl ketone + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160935", "l": "SMURF1 ubiquitinates RHOA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981713", "l": "C4b binds to cell surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9620103", "l": "ALDH2 transforms GTN to NO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50570", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62111", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine <=> a monoacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798749", "l": "Exocytosis of specific granule lumen proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625479", "l": "SRF and ELK1 bind the FOS gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20609", "l": "2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.2.28", "l": "\"2-dehydro-3-deoxy-D-pentonate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31629", "l": "10-deoxymethymycin + dTDP + H(+) => 10-deoxymethynolide + dTDP-alpha-D-desosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69883", "l": "L-ascorbate(out) + 2 Na(+)(out) = L-ascorbate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34690", "l": "AH2 + N-acyl-15-methylhexadecasphinganine + O2 <=> A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33085", "l": "5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine => dehypoxanthine futalosine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332235", "l": "CBL binds TGFBR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617828", "l": "TRIP11:IFT20 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008718", "l": "D-amino-acid dehydrogenase activity", "d": ["Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202717", "l": "Heterodimerization of CEACAMs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473594", "l": "Collagen type II degradation by MMP15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3814838", "l": "Defective GYG1 is not autoglucosyolated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140907", "l": "flavin-dependent halogenase activity", "d": ["Catalysis of the reaction: R-CH + a halogen + FADH2 + O2 = R-C-halogen + FAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375155", "l": "Interaction of NCAM1 with agrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419334", "l": "Melatonin receptors can bind melatonin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49142", "l": "dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5140741", "l": "WNT5A binds FZD and ROR receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64559", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one <=> 8-epi-ilicicolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70908", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9839402", "l": "TGFBR3 binding to GIPC1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112396", "l": "Separation of elongating transcript from template (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14703", "l": "CoA-disulfide + H(+) + NADH => 2 CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31929", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045438", "l": "delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity", "d": ["Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38060", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA => 1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61886", "l": "1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64380", "l": "3 A + phytyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49609", "l": "2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) => 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56551", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18380", "l": "ATP + streptomycin <=> ADP + H(+) + streptomycin 3''-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68914", "l": "DNA polymerase alpha:primase binds at the origin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48687", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O <=> [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63833", "l": "(6E)-8-methylnon-6-enoyl-CoA + vanillylamine => capsaicin + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67509", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9838289", "l": "CLPXP degrades mitochondrial matrix proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25973", "l": "H2O + N(8)-acetylspermidine + O2 => 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22445", "l": "(E)-coniferol + NADP(+) => (E)-coniferaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53706", "l": "H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine => 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093329", "l": "EFNBs bind SDCBP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17339", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+) => catechol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65572", "l": "(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] = (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43732", "l": "a triacyl-sn-glycerol + H2O = a 1,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46213", "l": "H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine => 4-amino-5-aminomethyl-2-methylpyrimidine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15422", "l": "a long-chain fatty acid + ATP + CoA => a long-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67443", "l": "H2O + N(alpha)-acetyl-L-methionine <=> acetate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193646", "l": "NGF binding to p75NTR inactivates RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41484", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19424", "l": "(R)-2-hydroxypropyl-coenzyme M <=> (R)-1,2-epoxypropane + coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35633", "l": "cyanidin 3-O-beta-D-galactoside + H(+) + UDP => cyanidin + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16320", "l": "(S)-indan-1-ol + NAD(+) <=> H(+) + indan-1-one + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202453", "l": "Auto-ubiquitination of TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74441", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in) => a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804996", "l": "p14ARF sequesters MDM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632958", "l": "PMS2 variants-defective DNA mismatch repair (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74540", "l": "creatinine(in) => creatinine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034827", "l": "1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + O2 = 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50455", "l": "prostaglandin H3 <=> prostaglandin E3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20677", "l": "alizarin + UDP-alpha-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.103", "l": "\"alizarin 2-beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917693", "l": "ESCRT Disassembly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429732", "l": "Multiphospho-CERT1-2 binds PPM1L, VAPA/B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805811", "l": "Release of SEPT4 from mitochondria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12985", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}, {"i": "EC:2.4.1.68", "l": "\"glycoprotein 6-alpha-L-fucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607043", "l": "factor VIIIa associates with cell membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468040", "l": "Cohesin binds PDS5 and WAPAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050064", "l": "luteolin 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: luteolin + UDP-alpha-D-glucuronate = luteolin 7-O-beta-D-glucosiduronate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210439", "l": "glutamate uptake by astrocytes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40896", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110218", "l": "Cleavage of uracil by TDG glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749197", "l": "ORC1 binds to H4K20me2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27415", "l": "CO2 + formaldehyde + morphine + succinate => 2-oxoglutarate + codeine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16119", "l": "acetoacetyl-CoA + AMP + diphosphate => acetoacetate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68259", "l": "L-cystine(in) + Na(+)(in) <=> L-cystine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54338", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71509", "l": "(+)-alpha-tocopherol(in) => (+)-alpha-tocopherol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428917", "l": "G13 activation by TP receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28655", "l": "glutathione S,S-dioxide + H2O = glutathione + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64057", "l": "(1S,2R)-ephedrine + NAD(+) => (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44458", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48852", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426149", "l": "SREBP1A,1C,2 binds the ELOVL6 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102900", "l": "dehydroabietadienal hydroxylase activity", "d": ["Catalysis of the reaction: dehydroabietadienal + NADPH + O2 = dehydroabietic acid + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0140034", "l": "methylation-dependent protein binding", "d": ["Binding to a protein upon methylation of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28846", "l": "choline(in) + H(+)(in) <=> choline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12603", "l": "2-oxoadipate + L-glutamate => 2-oxoglutarate + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38091", "l": "delta-tocotrienol + S-adenosyl-L-methionine = beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.271", "l": "\"crocetin glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57704", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) = 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76530", "l": "2'-deoxyguanosine + H(+) + H2O <=> 2'-deoxyxanthosine + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32598", "l": "7-isopropyl-4-methyloxepan-2-one + H2O <=> 6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30340", "l": "H(+) + L-tryptophan => CO2 + tryptamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40177", "l": "(2E)-octenoyl-CoA + H2O2 => O2 + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807581", "l": "HTN5, (HTN1, HTN3) binds fungal SSA1/SSA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16087", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-376851", "l": "SLC25A11 exchanges 2-OG and MAL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977224", "l": "Serum amyloid P binds DNA and chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44218", "l": "12-hydroxyoctadecanoyl-CoA + AMP + diphosphate => 12-hydroxyoctadecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41987", "l": "NAD(+) + propan-2-ol <=> acetone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706293", "l": "Active FLT3 binds to CBL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19128", "l": "glyoxylate + L-serine <=> 3-hydroxypyruvate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36187", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine = 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76992", "l": "H(+) + NAD(+) + reduced 2[4Fe-4S]-[ferredoxin] => NADH + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36519", "l": "H(+) + hexacosanoyl-CoA + malonyl-CoA = 3-oxooctacosanyol-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865320", "l": "CBFB binds RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8960973", "l": "RLBP1:11cRAL dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22650", "l": "apo-[cytochrome c] + heme b => holo-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2089971", "l": "Secretion of collagens (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62921", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol => 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44175", "l": "H2O + NAD(+) + tetradecanal <=> 2 H(+) + NADH + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050406", "l": "[acetyl-CoA carboxylase]-phosphatase activity", "d": ["Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134962", "l": "DHX36 binds DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046180", "l": "KSPG is secreted from the cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944214", "l": "Association of procollagen type I (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174808", "l": "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47613", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52216", "l": "[(1''->2')-ADP-alpha-D-ribose](n) + H2O = [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose", "d": [], "t": []}, {"i": "EC:3.2.1.143", "l": "\"poly(ADP-ribose) glycohydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19632", "l": "D-threo-isocitrate + NADP(+) <=> 2-oxoglutarate + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31426", "l": "(2Z,6E)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388560", "l": "EDNRA,EDNRB bind EDNs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187617", "l": "argininosuccinate <=> fumarate + arginine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034811", "l": "benzo(a)pyrene 9,10-dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015230", "l": "FAD transmembrane transporter activity", "d": ["Enables the directed movement of flavin-adenine dinucleotide (FAD) from one side of a membrane to the other. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419843", "l": "CALCA(83-119) binds CALCR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22614", "l": "acetyl-CoA + pyruvate => (3S)-citramalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37070", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5649856", "l": "Oxidative damage to the AP site (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682769", "l": "LGI2 binds ADAM22,23 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786190", "l": "CMBL hydrolyses OM to OLMS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23724", "l": "H2O + O2 + pyridoxal = 4-pyridoxate + H(+) + H2O2", "d": [], "t": []}, {"i": "EC:1.2.3.8", "l": "\"pyridoxal oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69343", "l": "(E)-prop-1-en-1-SO-peroxol <=> (Z)-propanethial S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56581", "l": "6-thioguanine + S-adenosyl-L-methionine => 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55487", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26241", "l": "geranylgeranyl diphosphate = diphosphate + elisabethatriene", "d": [], "t": []}, {"i": "EC:4.2.3.41", "l": "\"elisabethatriene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9865449", "l": "Metallochaperone inserts Cu2+ into MT-CO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62545", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin => dihydroouabagenin + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004560", "l": "alpha-L-fucosidase activity", "d": ["Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49580", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate", "d": [], "t": []}, {"i": "EC:4.6.1.17", "l": "\"cyclic pyranopterin monophosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74226", "l": "H2O + L-seryl-tRNA(Ala) <=> L-serine + tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52336", "l": "a long-chain fatty acid + ATP + H(+) = a long-chain fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005150", "l": "interleukin-1, type I receptor binding", "d": ["Binding to a Type I interleukin-1 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451377", "l": "Interaction of IQGAP1 with nephrin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61698", "l": "AMP + diphosphate + glycyl-[peptidyl-carrier protein] => ATP + glycine + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316347", "l": "RAB4A:GTP binds KIF3 and activates KIF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051737", "l": "GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: GTP + 5'-dephospho-DNA = GDP + 5'-phospho-DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44381", "l": "a 3-demethylubiquinol + S-adenosyl-L-methionine => a ubiquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655347", "l": "Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62573", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine => glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018560", "l": "protocatechuate 3,4-dioxygenase type II activity", "d": ["Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52114", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74854", "l": "acetaldehyde + dopamine <=> (R)-salsolinol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58484", "l": "H2O + N-(acetyl)-sphing-4-enine = acetate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21497", "l": "dimethylallyl diphosphate + H2O => diphosphate + prenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202328", "l": "Translocation of PKC theta to plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12366", "l": "a quinol + beta-nicotinamide D-riboside => 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42284", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45948", "l": "acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59243", "l": "L-arginine + L-lysine <=> L-homoarginine + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72119", "l": "(R)-carnitine(in) + glycine betaine(out) = (R)-carnitine(out) + glycine betaine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66010", "l": "[collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O => (5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40727", "l": "1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78551", "l": "Li(+)(in) = Li(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981657", "l": "IL34 dimer binds PTPRZ1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24879", "l": "A + L-sorbopyranose => 1-dehydro-L-sorbose + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40450", "l": "(2R)-pristanoyl-CoA <=> (2S)-pristanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853745", "l": "RET binds GFRA1,GFRA3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-141437", "l": "Formation of the MCC complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045516", "l": "interleukin-19 receptor binding", "d": ["Binding to an interleukin-19 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762246", "l": "ANGPTL4 binds CDH11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9860278", "l": "p-S446-IRF5 dimer translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59906", "l": "2 H(+) + NADPH + octanoate => H2O + NADP(+) + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16706", "l": "17alpha-estradiol + NADP(+) => estrone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0032550", "l": "purine ribonucleoside binding", "d": ["Binding to a purine ribonucleoside, a compound consisting of a purine base linked to ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70220", "l": "corticosterone + H(+) + NADPH => 20beta-dihydrocorticosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382056", "l": "Crk binds to the active PDGF receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12058", "l": "4-phospho-D-erythronate + 2 H(+) + NADH => D-erythrose 4-phosphate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42889", "l": "(R)-3-phosphomevalonate + ATP => (R)-3,5-bisphosphomevalonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43140", "l": "guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.216", "l": "\"tRNA (guanine(26)-N(2))-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448632", "l": "IL34 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62319", "l": "salicylate + UDP-alpha-D-glucose <=> 1-O-salicyl-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420980", "l": "Activation of Ca permeable AMPA receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59134", "l": "AMP + diphosphate + H(+) + staphyloferrin B => 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951727", "l": "cAMP binds PKA tetramer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050257", "l": "riboflavin phosphotransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75234", "l": "H2O + L-galactono-1,4-lactone <=> H(+) + L-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168894", "l": "p-STAT5A/B dissociates from the Growth Hormone receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70975", "l": "CS acetylates OA to citrate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68298", "l": "CoA + O-dodecanoyl-L-seryl-[protein] => dodecanoyl-CoA + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15342", "l": "ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide => ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0032036", "l": "myosin heavy chain binding", "d": ["Binding to a heavy chain of a myosin complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196753", "l": "2xPPCS ligates PPanK with Cys (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944255", "l": "Association of procollagen type VII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54711", "l": "N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112385", "l": "Addition of nucleotides leads to transcript elongation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46978", "l": "6-hydroxy-N-methylmyosmine + H2O2 => (S)-6-hydroxynicotine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085992", "l": "SUMOylation of DAXX with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46813", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22091", "l": "ATP + GTP <=> AMP + guanosine 3'-diphosphate 5'-triphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28874", "l": "D-fructuronate(in) + H(+)(in) <=> D-fructuronate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43666", "l": "2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate => ATP + hydrogencarbonate + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60181", "l": "ATP + D-fructose(out) + H2O => ADP + D-fructose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34226", "l": "6-hydroxypseudooxynicotine + A + H2O <=> 2,6-dihydroxypseudooxynicotine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082391", "l": "Trimerization of HSF1 in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62012", "l": "cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13682", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine => a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43716", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP", "d": [], "t": []}, {"i": "EC:2.7.7.89", "l": "\"[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59518", "l": "H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate => acetylsalicylate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23377", "l": "L-threonate + NAD(+) => 3-dehydro-D-erythronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77837", "l": "(2S)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]pentanedioate + H(+) + H2O2 => N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-glutamate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.042693372152272", "identifiers": [{"i": "GO:0004559", "l": "alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14998", "l": "deoxylimonoate + H2O => deoxylimononate D-ring-lactone + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43589", "l": "a globoside NORint + UDP-alpha-D-galactose => a globoside NOR2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67959", "l": "(S)-2-chloropropanoate + H2O <=> (R)-lactate + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62429", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA => 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24630", "l": "5 H(+) + 3 NADH + nitrite => 2 H2O + 3 NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16597", "l": "ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709317", "l": "CO binds to free ferrohemoglobin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74080", "l": "H(+) + menaquinone-4 + NADH => menaquinol-4 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59694", "l": "D-cellotrionate + H(+) => D-cellotriono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047365", "l": "quercetin-3-sulfate 3'-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H+ + quercetin 3,3'-disulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12873", "l": "(R)-2-hydroxy-4-methylpentanoate + NADP(+) = 4-methyl-2-oxopentanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70209", "l": "sphinga-4E,14Z-dienine-1-phosphate(out) => sphinga-4E,14Z-dienine-1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205286", "l": "GRB2:SOS interacts with p-KIT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35478", "l": "(1'S,5'S)-5'-hydroxyaverantin + NAD(+) <=> (S)-5'-oxoaverantin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428123", "l": "KDSR reduces 3-ketosphingoid (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449117", "l": "TXLNA (IL14) binds syntaxin1A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863674", "l": "CDC25C binds YWHAE (14-3-3-epsilon) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52827", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 <=> (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37942", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73205", "l": "D-glucose(in) + H(+)(out) => D-glucose(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047639", "l": "alcohol oxidase activity", "d": ["Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389381", "l": "Gads binds CD28 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018528", "l": "iminodiacetate dehydrogenase activity", "d": ["Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39560", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA => (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25663", "l": "(2E)-geranyl diphosphate => alpha-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66851", "l": "2 Cu(2+) + NADH <=> 2 Cu(+) + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602466", "l": "Activation of MT-MMPs by FURIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10737", "l": "a primary alcohol + NAD(+) => an aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9838035", "l": "CLPXP binds mitochondrial matrix proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19172", "l": "L-serine <=> NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65198", "l": "H(+) + NADH + NH4(+) + S-(acetaldehyde)-L-cysteine => H2O + NAD(+) + S-(2-aminoethyl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11213", "l": "indole + O2 => 2-formamidobenzaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32304", "l": "(2R)-homocitrate => (2R,3S)-homoisocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654569", "l": "Activated FGFR1 binds FRS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9843978", "l": "CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674018", "l": "BRAP binds RAS:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.22", "l": "\"coagulation factor IXa\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11009", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73941", "l": "dehydrogriseofulvin + H(+) + S-adenosyl-L-homocysteine => desmethyl-dehydrogriseofulvin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31354", "l": "lupan-3beta,20-diol <=> (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400434", "l": "FFAR1 binds fatty acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.55", "l": "\"E1 SAMP-activating enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.100", "l": "\"sedolisin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66606", "l": "a 2'-deoxyuridine in double-stranded DNA + NH4(+) => a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0140489", "l": "molecular template activity", "d": ["The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3878762", "l": "Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021068", "l": "PalmS-ESRs bind CAVs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24683", "l": "5,10-methylenetetrahydromethanopterin + NADP(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69050", "l": "6-hydroxyhexanoate + H(+) => H2O + hexano-6-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50320", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140749", "l": "phlorizin hydrolase activity", "d": ["Catalysis of the reaction: phlorizin + H2O = beta-D-glucose + phloretin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45580", "l": "D-galactaro-1,5-lactone = D-galactaro-1,4-lactone", "d": [], "t": []}, {"i": "EC:5.4.1.4", "l": "\"D-galactarolactone isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34087", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol = a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426676", "l": "Formation of laminin networks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013145", "l": "RAC1 binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167117", "l": "Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103066", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 4alpha-methyl-5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632652", "l": "Hh-Npp binds CDON and PTCH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209823", "l": "Tyrosine is hydroxylated to dopa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21882", "l": "2 CO2 + H2O2 => 2 H(+) + O2 + oxalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28609", "l": "L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047302", "l": "UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-glucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070497", "l": "6-carboxy-5,6,7,8-tetrahydropterin synthase activity", "d": ["Catalysis of the reaction: 7,8-dihydroneopterin triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622382", "l": "PIP2 hydrolysis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48310", "l": "(3Z)-6-oxohex-3-enoyl-CoA + formate + H(+) => 2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692749", "l": "CDC14A,B bind MAPK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59770", "l": "CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47729", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65566", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine => (9Z)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36124", "l": "gibberellin A20 + S-adenosyl-L-methionine => gibberellin A20 methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66528", "l": "ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] = diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18573", "l": "dihydrochelirubine + H(+) + O2 = chelirubine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0009883", "l": "red or far-red light photoreceptor activity", "d": ["The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72045", "l": "L-glutamate(out) + orotate(in) => L-glutamate(in) + orotate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615554", "l": "MIR137 gene expression is inhibited by MECP2 and SOX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72673", "l": "1,6-dihydroxyphenazine + CO2 + H2O + NAD(+) => 6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858489", "l": "ppDVL binds DAAM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22568", "l": "ascopyrone M = ascopyrone P", "d": [], "t": []}, {"i": "EC:5.3.2.7", "l": "\"ascopyrone tautomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54915", "l": "11-cis-retinol + NADP(+) <=> 11-cis-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48826", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+) => GDP-beta-L-fucose + Lc4Cer", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199583", "l": "KIR2DS2 interacting with HLA-C group 1 (Cw3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904067", "l": "ascr#2 binding", "d": ["Binding to ascr#2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674095", "l": "PDGFRs bind type II TKI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40891", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45840", "l": "(3R)-3-hydroxydecanoyl-CoA + NADP(+) = 3-oxodecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13913", "l": "L-threonine = D-threonine", "d": [], "t": []}, {"i": "EC:5.1.1.6", "l": "\"threonine racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102424", "l": "sesaminol-2-O-gentiobioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-sesaminol 2-O-beta-D-gentiobioside + UDP-alpha-D-glucose = (+)-sesaminol 2-O-beta-D-gentiotrioside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140581", "l": "P-type monovalent copper transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu+(in) = ADP + phosphate + Cu+(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989745", "l": "Expression of ACADM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676133", "l": "CD74 binds MIF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68002", "l": "A + chloride + chloroethene + H(+) => 1,1-dichloroethene + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140580", "l": "mitochondrion autophagosome adaptor activity", "d": ["The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31434", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-beta-santalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9833973", "l": "ISGylation of PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70793", "l": "H(+)(out) + L-ornithine(in) => H(+)(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937814", "l": "RUNX3 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64745", "l": "H2O + S-3-(hexan-1-ol)-L-cysteine => 3-sulfanyl-1-hexanol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71279", "l": "chloride(out) + L-leucine(out) + 2 Na(+)(out) = chloride(in) + L-leucine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-178208", "l": "SMAD7 binds to SMURF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75172", "l": "Formation of RAD50:MRE11 complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75025", "l": "2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9864415", "l": "AAC1 imports a proton (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54723", "l": "N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660015", "l": "Defective RPIA does not isomerize R5P to RU5P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65132", "l": "2-oxoglutarate + O2 + preaustinoid A1 = CO2 + H2O + preaustinoid A2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62830", "l": "GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623281", "l": "FOXO1:PPARGC1A,FOXO4 binds PCK1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000810", "l": "diacylglycerol diphosphate phosphatase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18832", "l": "4-phospho-D-erythronate + NAD(+) <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29998", "l": "ATP + H2O + putrescine(out) <=> ADP + H(+) + phosphate + putrescine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080122", "l": "AMP transmembrane transporter activity", "d": ["Enables the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451508", "l": "Nuclear translocation of phospho ERK2 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226979", "l": "ADD1:ADD2 binds DMTN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018746", "l": "RHOQ binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55253", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine => 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26549", "l": "beta-alaninamide + H2O <=> beta-alanine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9761474", "l": "AMOT-2 binds CDH11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58993", "l": "(E)-cinnamaldehyde + H2O + O2 => (E)-cinnamate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433501", "l": "Interaction of other adapter proteins with p-KIT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35790", "l": "paromamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin C + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31000", "l": "(S)-2,3-epoxysqualene => cucurbitadienol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52971", "l": "hyocholate + UDP-alpha-D-glucuronate <=> H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74798", "l": "N-methyl-(R)-salsolinol(in) <=> N-methyl-(R)-salsolinol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047351", "l": "GTP guanylyltransferase activity", "d": ["Catalysis of the reaction: 2 GTP + H+ = P(1),P(4)-bis(5'-guanosyl) tetraphosphate + diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66073", "l": "4-methyl-2-oxopentanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-532603", "l": "Nephrin mediated activation of N-WASP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12190", "l": "CO2 + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] => 2-oxoglutarate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60912", "l": "cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65913", "l": "3-hydroxy-L-kynurenine + pyruvate => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227694", "l": "dsRNA binds to MDA5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022141", "l": "Prolysyl oxidase activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54691", "l": "alliin <=> 2-aminoprop-2-enoate + allylsulfenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56597", "l": "(1S,4S)-bornane-2,5-dione + FMNH2 + O2 => (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211904", "l": "CYP4F12 18-hydroxylates ARA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72697", "l": "Start codon recognition (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70501", "l": "PC carboxylates PYR to OA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53628", "l": "(2E,6E)-farnesyl diphosphate = (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.160", "l": "\"(2S,3R,6S,9S)-(-)-protoillud-7-ene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16834", "l": "2 glutathione + H2O2 => glutathione disulfide + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322434", "l": "XIAP dissociates from ub-TLE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60463", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79101", "l": "H2O + L-histidocholate => cholate + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437234", "l": "Heat-Stable Antigen binds L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30456", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O => (-)-geosmin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656258", "l": "Defective ST3GAL3 does not transfer SA to keratan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010539", "l": "SLIT2 gene expression is stimulated by ISL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72663", "l": "De novo formation of eIF2:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49604", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) = 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611851", "l": "ADRB2 bind ADR,NAd (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050345", "l": "trans-epoxysuccinate hydrolase activity", "d": ["Catalysis of the reaction: trans-2,3-epoxysuccinate + H2O = (2R,3S)-tartrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022396", "l": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-43) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62560", "l": "(4R)-limonene + A + H2O = (4R)-perillyl alcohol + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54043", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (3E,7E)-dolathalia-3,7,11-triene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69645", "l": "(2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65904", "l": "3-hydroxy-L-kynurenine + glyoxylate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77874", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-leucine + O2 <=> (2S)-4-methyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]pentanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22139", "l": "7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 <=> chlorophyllide b + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52232", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + Fe(2+) + 3 H2O + mycobilin a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69185", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-glycerol 1-phosphate => diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70488", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2 => a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73150", "l": "adenosine 3',5'-bisphosphate(out) + FAD(in) <=> adenosine 3',5'-bisphosphate(in) + FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75760", "l": "(9Z,11E)-octadecadienoate + H2O => 10-hydroxy-(11E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40638", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709317", "l": "CO binds to free ferrohemoglobin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46406", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625210", "l": "Defective SLC22A12 does not exchange extracellular urate for cytosolic LACT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69685", "l": "CHEK2 phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45373", "l": "H2O + N-(9Z-octadecenoyl)-sphinganine => (9Z)-octadecenoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33519", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine = (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53789", "l": "allodeoxycholoyl-CoA + beta-muricholate => allodeoxycholate + beta-muricholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20681", "l": "cis-zeatin + UDP-alpha-D-glucose = H(+) + O-beta-D-glucosyl-cis-zeatin + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.215", "l": "\"cis-zeatin O-beta-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53839", "l": "a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine <=> a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27655", "l": "2-oxobutanoate + H(+) + pyruvate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012205", "l": "Estrogen-responsive CHD1 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9652264", "l": "ERBB2 binds TKIs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043800", "l": "hexulose-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35682", "l": "dodecanoyl-CoA + H(+) + L-serine <=> 3-oxotetradecasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74660", "l": "N-acetyl-D-glucosamine + UTP => H(+) + N-acetyl-D-glucosamine 6-phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015650", "l": "lactate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614669", "l": "FASLG gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59187", "l": "2,4-diacetylphloroglucinol + H2O <=> 2-acetylphloroglucinol + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72077", "l": "ADP + H(+) + ophthalmate + phosphate => ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428205", "l": "ACER2 hydrolyzes ceramide (Golgi) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36993", "l": "alpha-D-ribose 1,5-bisphosphate + uracil => phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15883", "l": "ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein] => ATP + L-seryl-[Fas-activated protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42440", "l": "L-aspartate + NAD(+) = H(+) + iminosuccinate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391168", "l": "SIRP gamma binds CD47 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23224", "l": "trans-zeatin + UDP-alpha-D-glucose = H(+) + O-beta-D-glucosyl-trans-zeatin + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.203", "l": "\"trans-zeatin O-beta-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34363", "l": "H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}, {"i": "EC:2.7.7.83", "l": "\"UDP-N-acetylgalactosamine diphosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012650", "l": "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782895", "l": "TYW1:FMN:4Fe-4S  transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55300", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905576", "l": "ganglioside GT1b binding", "d": ["Binding to ganglioside GT1b."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848726", "l": "PTK6 phosphorylates BCAR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66574", "l": "2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 2-naphthol + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18891", "l": "alpha,alpha-trehalose 6-phosphate + H(+) + UDP => D-glucose 6-phosphate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.1", "l": "\"anthranilate 1,2-dioxygenase (deaminating, decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23407", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate <=> diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0016843", "l": "amine-lyase activity", "d": ["Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate."], "t": []}, {"i": "EC:4.3.3.-", "l": "\"Amine-lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21834", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27686", "l": "ATP + GDP = ADP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849900", "l": "SALMs1-3 bind each other in cis interactions (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78130", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68291", "l": "heptanoyl-CoA + L-seryl-[protein] <=> CoA + O-heptanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953356", "l": "Expression of EXTL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43285", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41686", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+) => 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10464", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = n acetate + chitosan", "d": [], "t": []}, {"i": "EC:3.5.1.41", "l": "\"chitin deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71401", "l": "OGDH dimer decarboxylates 2-OG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0030169", "l": "low-density lipoprotein particle binding", "d": ["Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247849", "l": "WLS dissociates from retromer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030110", "l": "HLA-C specific inhibitory MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11785", "l": "H2O + L-aspartate + NADP(+) => H(+) + NADPH + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16630", "l": "(S)-malyl-CoA => acetyl-CoA + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66515", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52389", "l": "ATP + D-threonate => 4-O-phospho-D-threonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68737", "l": "ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase] => ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46319", "l": "GDP-N,N'-diacetylbacillosamine + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11192", "l": "an (S)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57171", "l": "(R)-2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655339", "l": "Activated FGFR2 mutants bind FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10676", "l": "(2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77328", "l": "L-ornithine + pyruvate => 5-amino-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004508", "l": "steroid 17-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41639", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O <=> 1-O-(1Z-alkenyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372529", "l": "Release of acetylcholine at the synapse (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42579", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O <=> 2-methylpropanoate + 2-oxopent-4-enoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22183", "l": "(S)-norreticuline + S-adenosyl-L-methionine <=> (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67236", "l": "mycophenolyl-CoA + propanoyl-CoA = (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032143", "l": "single thymine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single thymine insertion or a deletion that results in an unpaired thymine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050226", "l": "psychosine sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43566", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate => 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209293", "l": "Phosphorylation of CI by CKIalphaepsilon (CKIalpha/DCO) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070204", "l": "2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + H+ + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.441482309351898", "identifiers": [{"i": "GO:0000976", "l": "transcription cis-regulatory region binding", "d": ["Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042988", "l": "X11-like protein binding", "d": ["Binding to X11-like protein, a neuron-specific adaptor protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372542", "l": "Loading of dopamine into synaptic veiscles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46816", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45124", "l": "acarbose + ATP = acarbose 7(IV)-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.187", "l": "\"acarbose 7(IV)-phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014294", "l": "RAC2 binds effectors at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78433", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0003688", "l": "DNA replication origin binding", "d": ["Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374662", "l": "Translocation of Ezrin to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9667965", "l": "ANKLE2 binds PP2A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68994", "l": "3-amino-2,4-dihydroxybenzoate + H2O + NADP(+) => 3-amino-4-hydroxybenzoate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57734", "l": "AH2 + all-trans-retinol => A + all-trans-7,8-dihydroretinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57255", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP <=> glycolate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.6", "l": "\"carboxypeptidase D\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75039", "l": "acetyl-CoA(in) = acetyl-CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12158", "l": "2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH => 2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678544", "l": "IL17RA:IL17RE binds IL17C dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392852", "l": "Activated prostacyclin receptor binds G-protein Gs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68923", "l": "ATP + H(+) + NADPH + pentanoate <=> AMP + diphosphate + NADP(+) + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57368", "l": "H2O + NADPH = (6R)-NADPHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16558", "l": "2-amino-3-carboxymuconate 6-semialdehyde + H(+) => 2-aminomuconate 6-semialdehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004856", "l": "D-xylulokinase activity", "d": ["Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64554", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65774", "l": "1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.798022316275805", "identifiers": [{"i": "GO:0004601", "l": "peroxidase activity", "d": ["Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685605", "l": "SLAMF7 binds SLAMF7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706344", "l": "FLT3 phosphorylates GRB10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9702849", "l": "CALCR binds gepants (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61152", "l": "(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427337", "l": "MBD2 binds methylcytosine in chromatin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74060", "l": "beta-alanine(out) + L-alanine(in) => beta-alanine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43926", "l": "H(+) + NADH + pregn-5-ene-3,20-dione => NAD(+) + pregnenolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18823", "l": "acetylcholine + CoA => acetyl-CoA + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69608", "l": "acetyl-CoA + N-terminal L-methionyl-[tubulin] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74836", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-galactosamine(in) => UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-galactosamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15189", "l": "2 Fe(III)-[cytochrome c553] + formate = CO2 + 2 Fe(II)-[cytochrome c553] + H(+)", "d": [], "t": []}, {"i": "EC:1.17.2.3", "l": "\"formate dehydrogenase (cytochrome c-553)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28219", "l": "chloride + H(+) + H2O2 => H2O + hypochlorous acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39672", "l": "(9Z)-hexadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913446", "l": "Interleukin-5 is a homodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43885", "l": "3-oxochol-4-en-22-oyl-CoA + NAD(+) => 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614591", "l": "Excess cysteine yields lanthionine and H2S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74095", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19783", "l": "3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + 3,5-diiodo-L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3772430", "l": "CTNNBIP1 binds beta-catenin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73754", "l": "(R)-adrenaline(in) + 2 H(+)(out) <=> (R)-adrenaline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78467", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP-N-acetyl-beta-neuraminate = a ganglioside GM3 + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213201", "l": "Formation of collagen fibres (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696146", "l": "AOC2 deaminates TYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60767", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone <=> cinerin II + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34016", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 => ergosterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24186", "l": "3,4-dihydroxybenzoate + CO2 => 4,5-dihydroxyphthalate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13123", "l": "3-phosphoshikimate + ADP + H(+) => ATP + shikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189488", "l": "UROS transforms HMB to URO3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58132", "l": "A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] = AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15908", "l": "3-hydroxycyclohexanone + A <=> AH2 + cyclohexane-1,3-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000402", "l": "crossed form four-way junction DNA binding", "d": ["Binding to a DNA segment containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33417", "l": "[(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+) => bornane-2,6-dione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9858589", "l": "DLD dimer dehydrogenates dihydrolipoyl (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741411", "l": "CYLD deubiquitinates NEMO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465940", "l": "atRAL is reduced to atROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050350", "l": "trihydroxystilbene synthase activity", "d": ["Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64766", "l": "2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol => S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36946", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1236970", "l": "Proteasomal clevage of exogenous antigen (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32138", "l": "2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098605", "l": "selenocystathionine beta-synthase activity", "d": ["Catalysis of the reaction: L-Serine + Selenohomocysteine => L-Selenocystathionine + H2O."], "t": []}, {"i": "REACT:R-HSA-2408559", "l": "SeHCys and Ser are dehydrated into SeCysta by CBS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74604", "l": "CMP(out) + UDP-alpha-D-galactose(in) => CMP(in) + UDP-alpha-D-galactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9861626", "l": "SIRT4 cleaves lipoyl from DLAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380198", "l": "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174731", "l": "Degradation of newly synthesized ApoB-48 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110035", "l": "rDNA spacer replication fork barrier binding, bending", "d": ["The activity of binding selectively, and in a sequence-specific manner, a replication fork barrier found in rDNA spacers, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75512", "l": "acetyl-CoA + S-benzyl-L-cysteine => CoA + H(+) + N-acetyl-S-benzyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54042", "l": "(3E,7E)-dolathalia-3,7,11-triene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28977", "l": "H(+)(in) + L-asparagine(out) => H(+)(out) + L-asparagine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65614", "l": "a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57176", "l": "L-arginyl-[protein] + methylglyoxal = N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37573", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58509", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O => (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55277", "l": "9-cis-retinol + tetradecanoyl-CoA => 9-cis-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034739", "l": "histone H4K16 deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8963915", "l": "1,25(OH)2D binds VDR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77697", "l": "a ganglioside GM1alpha (d18:1(4E)) + CMP + H(+) => a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682388", "l": "Autophagosome maturation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60753", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone => CoA + jasmolin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64117", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983266", "l": "Kinesins bind microtubules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875817", "l": "MET phosphorylates STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382053", "l": "Translocation of PDGF from ER to Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159733", "l": "Furin cleaves pro-factor X to factor X (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613530", "l": "PRKAA2 phosphorylates PLINs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18126", "l": "A + a D-alpha-amino acid + H2O => a 2-oxocarboxylate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21356", "l": "L-arabinitol + NAD(+) = H(+) + L-ribulose + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.13", "l": "\"L-arabinitol 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726509", "l": "NR3C2 binds fludrocortisone (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046876", "l": "3,4-didehydroretinal binding", "d": ["Binding to 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21571", "l": "beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O <=> beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51676", "l": "[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54881", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => (3R)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41687", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O <=> 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804383", "l": "PRMT5 methylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849908", "l": "SALM4 binds flotillin-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46061", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17673", "l": "quercetin + S-adenosyl-L-methionine = 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.76", "l": "\"quercetin 3-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784462", "l": "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9645598", "l": "RRAGC,D hydrolyzes GTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14028", "l": "H(+) + H2O + sepiapterin <=> NH4(+) + xanthopterin-B2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18150", "l": "H2O + N-acetyl-D-galactosamine 6-phosphate => acetate + D-galactosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77755", "l": "(4E,11E)-2-hydroxytrideca-4,11-dien-1,2,3-tricarboxylate + 2 H(+) = [4-(deca-1,8-diyl)-2,5-dioxo-2,5-dihydro-3-furanyl]acetate + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839376", "l": "TGFBR3(784-851) degradation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0035727", "l": "lysophosphatidic acid binding", "d": ["Binding to lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66687", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] <=> L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60877", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871260", "l": "YAP1 binds TEAD2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27585", "l": "(S)-2-hydroxymethylglutarate <=> 2-methyleneglutarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76958", "l": "2-methylbutanamine + H2O + NAD(+) <=> 2-methylbutanal + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38559", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate = (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.129", "l": "\"long-chain acyl-CoA omega-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202510", "l": "Activation of TAK1-TAB2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75965", "l": "15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione => 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67654", "l": "2'-deoxyadenosine + diphosphate => dADP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72368", "l": "estrone 3-sulfate(out) + succinate(in) => estrone 3-sulfate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33554", "l": "an N-acylsphinganine + H2O <=> a fatty acid + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24675", "l": "ATP + cytidine => ADP + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51128", "l": "A + an aliphatic amine + H2O = AH2 + an aldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2025890", "l": "Calcineurin binds NFATC1,2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102795", "l": "1-naphthaldehyde:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: 1-naphthaldehyde + O2 + H2O = H+ + 1-naphthoate + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9824897", "l": "p-S-TBK1 phosphorylates OPTN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31637", "l": "5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc => beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033458", "l": "GAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GAC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28901", "l": "glycine(out) + H(+)(out) => glycine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44611", "l": "3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156678", "l": "Activation of Cdc25C (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37656", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76435", "l": "(2S,9S)-annullatin H + 2 A = (2S,9S)-annullatin D + 2 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61917", "l": "ATP + fluconazole(in) + H2O => ADP + fluconazole(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32798", "l": "ATP + H2O + L-cysteine(out) <=> ADP + H(+) + L-cysteine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28008", "l": "formaldehyde + H2O2 + L-tryptophan => H2O + N(alpha)-methyl-L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35805", "l": "7,8-dihydroneopterin 2'-phosphate + H(+) => 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37570", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68917", "l": "ATP + butanoate + H(+) + NADPH => AMP + butanal + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16641", "l": "a long-chain fatty acyl ethyl ester + H2O = a long-chain fatty acid + ethanol + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.67", "l": "\"fatty-acyl-ethyl-ester synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43028", "l": "L-cysteate = 2-aminoprop-2-enoate + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75849", "l": "SLC25A1 exchanges CIT and MAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64372", "l": "beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O = alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35530", "l": "H(+) + N-ethylmaleimide + NADH <=> N-ethylsuccinimide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24045", "l": "3,4-dihydroxybenzoate + O2 => 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28074", "l": "(2R)-3-sulfopropanediol + H2O + 2 NAD(+) = (2R)-3-sulfolactate + 3 H(+) + 2 NADH", "d": [], "t": []}, {"i": "EC:1.1.1.308", "l": "\"sulfopropanediol 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72891", "l": "acetylcholine(out) + 2 H(+)(in) = acetylcholine(in) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36634", "l": "D-ribulose 1,5-bisphosphate + O2 <=> (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046353", "l": "aminoglycoside 3-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 3-N-acetylaminoglycoside. This is acetylation of the 3-amino group of the central deoxystreptamine ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74911", "l": "a (2E)-enoyl fatty acid + ATP + holo-[ACP] = a (2E)-enoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.34", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362386", "l": "Glycosylation of Hh (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.2", "l": "\"lysoplasmalogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69289", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate => sulfate + sulforaphane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37357", "l": "phosphate + uridine => H2O + uridine 2'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51329", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917811", "l": "STEAP3,STEAP4 reduce Fe3+ to Fe2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58917", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene => (S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42077", "l": "2-hydroxyglutarate + acetyl-CoA => 2-hydroxyglutaryl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019159", "l": "nicotinamide-nucleotide amidase activity", "d": ["Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49967", "l": "5,10-dihydrophenazine + O2 <=> H2O2 + phenazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4332356", "l": "CAMK2 binds MAP3K7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008894", "l": "PTPNs gene transcription and translation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36705", "l": "(3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+) => (2S,5S)-5-carboxymethylproline + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392530", "l": "p-S400-Cot phosphorylates NIK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034458", "l": "3'-5' RNA helicase activity", "d": ["Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis."], "t": []}, {"i": "REACT:R-HSA-9836927", "l": "SUPV3L1 unwinds double-stranded mitochondiral RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31402", "l": "all-trans-4,4'-diapophytofluene + FAD + H(+) <=> all-trans-4,4'-diapo-zeta-carotene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67513", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034528", "l": "2-carboxy-2-hydroxy-8-carboxychromene isomerase activity", "d": ["Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875531", "l": "MET binds TNS4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36067", "l": "Co-precorrin-6B + S-adenosyl-L-methionine = Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.196", "l": "\"cobalt-precorrin-6B (C(15))-methyltransferase [decarboxylating]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60786", "l": "CO2 + gibberellin A25 + H(+) + succinate => 2-oxoglutarate + gibberellin A24 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55574", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine => 4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38292", "l": "(S)-malyl-CoA + H2O => (S)-malate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.52", "l": "\"diphosphoinositol-polyphosphate diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10480", "l": "2-oxoglutarate + 4-hydroxy-L-glutamate = 4-hydroxy-2-oxoglutarate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835411", "l": "FA core complex:HSP70s binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61771", "l": "rebaudioside A + UDP-alpha-D-glucose <=> H(+) + rebaudioside D + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73714", "l": "ATP(in) + UTP(out) <=> ATP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64878", "l": "H(+) + phosphate + UMP => H2O + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68060", "l": "a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51002", "l": "[fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine => [fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17012", "l": "2-succinylbenzoate + ATP + CoA <=> 2-succinylbenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11615", "l": "H2O + L-glutamate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59113", "l": "ATP + L-serine => ADP + H(+) + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-532549", "l": "MPI isomerises Fru6P to Man6P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836500", "l": "IKK complex is activated by PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34733", "l": "CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine => 15-methylhexadecasphing-4-enine + a fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43713", "l": "ATP + dodecanoate + H(+) => diphosphate + dodecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41119", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161293", "l": "Tropoelastin forms aggregate globules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12513", "l": "D-aspartate + H2O + O2 => H2O2 + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201629", "l": "Caspase-mediated cleavage of Tau (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69347", "l": "(E)-but-1-en-1-SO-peroxol <=> (Z)-butanethial oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-398185", "l": "LARG binds plexin B1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72006", "l": "(S)-lactate(in) + urate(out) <=> (S)-lactate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102876", "l": "psoralen synthase activity", "d": ["Catalysis of the reaction: (+)-marmesin + NADPH + H+ + O2 = psoralen + NADP + acetone + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68743", "l": "7-oxocholesterol + H(+) + NADPH <=> 7alpha-hydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12404", "l": "D-glucose + UDP-alpha-D-galactose = H(+) + lactose + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.22", "l": "\"lactose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15217", "l": "ecdysone + hexadecanoyl-CoA = CoA + ecdysone hexadecanoate", "d": [], "t": []}, {"i": "EC:2.3.1.139", "l": "\"ecdysone O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11269", "l": "D-cysteine + H2O => H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31583", "l": "2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.56", "l": "\"2-hydroxy-dATP diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68897", "l": "4-hydroxybenzoate + ATP + H(+) + NADPH => 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16064", "l": "H2O + sn-glycerol 3-phosphocholine <=> choline + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43485", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19663", "l": "beta-D-fructose 6-phosphate + H(+) + NADH => D-mannitol 1-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61820", "l": "3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose = epiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28174", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate = colneleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37264", "l": "ATP + H2O + L-alanyl-L-aspartate(out) => ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43909", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O => D-galactose + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38082", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA <=> 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77346", "l": "N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate <=> 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32731", "l": "a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635102", "l": "GPR161 is internalized (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52214", "l": "ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin] => acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467811", "l": "Separation of sister chromatids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21881", "l": "2 H(+) + O2 + oxalate => 2 CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17602", "l": "ATP + D-ribulose => ADP + D-ribulose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928614", "l": "EFNB:GRB4 binds GIT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869566", "l": "The MYBL2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62230", "l": "AH2 + patulin => (E)-ascladiol + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.32", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45733", "l": "D-ribulose 5-phosphate + L-tyrosine => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68783", "l": "(2Z,6Z)-farnesyl diphosphate <=> alpha-humulene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78056", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine => 2-(acylamino)ethyl fatty acid + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22511", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) <=> diphosphate + DNA(n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24446", "l": "GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762100", "l": "MYC- and NICD1-dependent NFE2L2 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868260", "l": "CDK5:p25 phosphorylates GOLGA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614544", "l": "Sulfite is oxidized to sulfate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47134", "l": "11-cis-retinoate + 2 H(+) + NADH => 11-cis-retinal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42257", "l": "H(+) + hexanoyl-CoA + malonyl-[ACP] => 3-oxooctanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166753", "l": "Conversion of C4 into C4a and C4b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12775", "l": "CO2 + dihydroclavaminate + H2O + succinate => 2-oxoglutarate + O2 + proclavaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17348", "l": "(S)-methylmalonyl-CoA + H2O <=> CoA + H(+) + methylmalonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74368", "l": "substance P(out) => substance P(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13000", "l": "(E)-feruloyl-CoA + galactarate <=> 2-O-[(E)-feruloyl]-D-galactarate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72168", "l": "2 Na(+)(out) + taurohyodeoxycholate(out) => 2 Na(+)(in) + taurohyodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75856", "l": "Abortive Initiation Before Second Transition (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59086", "l": "2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+) => 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72712", "l": "cathenamine + H(+) => 4,21-dehydrogeissoschizine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70967", "l": "IDH3 complex decarboxylates isocitrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40636", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140857", "l": "histone H3T45 kinase activity", "d": ["Catalysis of the reaction: histone H3-threonine (position 45) + ATP = histone H3-phosphothreonine (position 45) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 45 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396007", "l": "IRF3 is phosphorylated by TBK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420117", "l": "VEGFR2 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48908", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59617", "l": "beta-alanyl-L-arginine + H2O => beta-alanine + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046576", "l": "rhamnogalacturonan alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase activity", "d": ["Catalysis of the cleavage of rhamnogalacturonan, generating oligosaccharides of the form alpha-D-us-galacturonic acid-(1,2)-alpha-L-rhamnose-(1,4)-alpha-D-galacturonate-(1,2)-L-rhamnose-(1,2)-alpha-L-rhamnose-p-(1,4)-alpha-D-galacturonic acid, terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003689", "l": "DNA clamp loader activity", "d": ["Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56634", "l": "1,8-cineole + diphosphate => H2O + neryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61720", "l": "a D-guloside + NAD(+) = a 3-dehydro-D-guloside + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67157", "l": "1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26211", "l": "acetaldehyde + glycine => L-allo-threonine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32814", "l": "benzoate(in) <=> benzoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66903", "l": "acetyl-CoA + L-tryptophan + malonyl-CoA <=> CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.10", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34869", "l": "AMP + diphosphate + thiophene-2-carbonyl-CoA => ATP + CoA + thiophene-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45371", "l": "H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + (9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69586", "l": "guanosine + IMP => GMP + inosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65716", "l": "2-oxoglutarate + a primary linear alkyl sulfate ester + O2 = an aldehyde + CO2 + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71238", "l": "[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] <=> [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46745", "l": "ATP + hydrogencarbonate => ADP + carboxyphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912416", "l": "NOTCH1 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16714", "l": "H2O + S-succinylglutathione => glutathione + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72899", "l": "4-O-demethylbarbatate + S-adenosyl-L-methionine = proatranorin I + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034070", "l": "aminoglycoside 1-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114683", "l": "Phosphorylation of Platelet Sec-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63032", "l": "a fatty acylamide + H2O = a fatty acid + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17322", "l": "L-tryptophan + S-adenosyl-L-methionine => 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858475", "l": "ppDVL recruits RAC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31016", "l": "H(+) + indole-3-carboxylate => CO2 + indole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913451", "l": "IL3RB is phosphorylated on Ser-585 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74941", "l": "a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + CO2 + succinate => 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730840", "l": "Activation of RAC1 by VAV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41233", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102712", "l": "gibberellin A13,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A13 + 2-oxoglutarate + O2 = gibberellin A43 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428752", "l": "Dissociation of the TP:Gq complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.97", "l": "\"methyltetrahydroprotoberberine 14-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0099085", "l": "DIF dechlorinase activity", "d": ["Catalysis of the reaction: 1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one => 1-[(3-chloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one + Cl-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731077", "l": "SARS-CoV-1 8b binds to IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.15", "l": "\"D-glutamate(D-aspartate) oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76244", "l": "a glycyl-glycyl-[protein] + H2O => [protein]-C-terminal glycine + N-terminal glycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61749", "l": "rubusoside + UDP-alpha-D-glucose => H(+) + stevioside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27588", "l": "indole-3-pyruvate + L-alanine => L-tryptophan + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73938", "l": "griseophenone B + H(+) + O2 + reduced [NADPH--hemoprotein reductase] <=> desmethyl-dehydrogriseofulvin + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71450", "l": "D-alanine(in) + Na(+)(in) <=> D-alanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050629", "l": "tetrachloroethene reductive dehalogenase activity", "d": ["Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor. The reaction occurs in the reverse direction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47428", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) = 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13020", "l": "diphosphate + UMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40539", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445079", "l": "Phosphorylation of L1 by ERK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35884", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709179", "l": "DPP4 binds DPP4 inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33719", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663124", "l": "p-BMAL1:p-CLOCK,NPAS2 binds SERPINE1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72667", "l": "O2 + reduced [NADPH--hemoprotein reductase] + secologanin = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11207", "l": "apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24981", "l": "3-hydroxy-4-methylanthranilate + ATP + H(+) => 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45993", "l": "(3R)-3-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45093", "l": "H2O + N-octanoylsphing-4-enine => octanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38580", "l": "dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211959", "l": "CYP3A43 6b-hydroxylates TEST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791295", "l": "Aggrecan degradation by MMP1,2,3,7,9,12,13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798474", "l": "S100A8:S100A9 binds Zn2+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0015368", "l": "calcium:monoatomic cation antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in)."], "t": []}, {"i": "REACT:R-HSA-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58674", "l": "aldehydo-D-glucuronate => D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18271", "l": "ethyl 3-oxohexanoate + H(+) + NADPH => ethyl (S)-3-hydroxyhexanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24593", "l": "CTP + H(+) + phosphoethanolamine => CDP-ethanolamine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52331", "l": "L-arginine + O2 + reduced [flavodoxin] <=> H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082369", "l": "Acetylated HSF1 dissociates from DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353268", "l": "Binding of Pol zeta complex to a DNA template containing lesions (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000246", "l": "delta24(24-1) sterol reductase activity", "d": ["Catalysis of the reaction: ergosterol + NADP+ = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22851", "l": "(3S)-hydroxyoctanedioyl-CoA + NAD(+) <=> 3-oxooctanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32153", "l": "(12E)-9alpha-labda-8(17),12,14-triene + diphosphate => 9alpha-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177692", "l": "Activation of recruited TAK1 within the activated TLR3 complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59626", "l": "4-aminobutanoate + L-ornithine => H2O + N(2)-(4-aminobutanoyl)-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76593", "l": "N,N-dimethylglycine(in) + Na(+)(in) => N,N-dimethylglycine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849085", "l": "ARHGAP35 binds RHOA:GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23167", "l": "a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose <=> a flavonol 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50074", "l": "ADP + H(+) + phosphate + tauroursodeoxycholate(out) => ATP + H2O + tauroursodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49411", "l": "[(1->2)-beta-D-mannosyl](n) + phosphate <=> [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17872", "l": "5,6,7,8-tetrahydropteridine + NAD(+) <=> 6,7-dihydropteridine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391913", "l": "FPR2 binds FPR2 ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017045", "l": "corticotropin-releasing hormone activity", "d": ["The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50316", "l": "ethyl octadecanoate + H2O = ethanol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39616", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA => (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250880", "l": "botF HC:LC binds SV2A or B or C and GT1b on the target cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379387", "l": "COMT transfers Met to DA to form 3MT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61308", "l": "(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174963", "l": "NAT1 acetylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40241", "l": "AMP + diphosphate + dodecanedioyl-CoA => ATP + CoA + dodecanedioate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51530", "l": "CO2 + guaiacol => H(+) + vanillate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51434", "l": "[(1S)-1-acetamidoethyl]phosphonate + CoA => (S)-1-aminoethylphosphonate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58166", "l": "7-epi-ent-eudesmane-5,11-diol + diphosphate => (2E,6E)-farnesyl diphosphate + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618331", "l": "HDAC6 deacetylates microtubules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60475", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051434", "l": "BH3 domain binding", "d": ["Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38188", "l": "19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59089", "l": "D-histidine + S-adenosyl-L-methionine => (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53488", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH = 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008036", "l": "diuretic hormone receptor activity", "d": ["Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34371", "l": "H2O + indole-3-acetamide = (indol-3-yl)acetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855648", "l": "SALM3 binds LAR-RPTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222722", "l": "Mycobactin is exported (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604732", "l": "Autocatalytic activation of proMMP13 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632677", "l": "PTCH is internalized (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48229", "l": "a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] => a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62178", "l": "alpha-D-glucose 1-phosphate + GMP + 2 H(+) => GDP-alpha-D-glucose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51744", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A = a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29231", "l": "cyanate(in) = cyanate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5660665", "l": "Caspase-8 binds MALT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55599", "l": "a globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine <=> a globoside NORint + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65303", "l": "2-oxoglutarate + chrodrimanin C + O2 <=> CO2 + H2O + succinate + verruculide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25932", "l": "4-methylquinoline + A + H2O = 4-methylquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0047154", "l": "methylmalonyl-CoA carboxytransferase activity", "d": ["Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41631", "l": "geranylgeranyl diphosphate + H2O <=> cyclooctat-9-en-7-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57982", "l": "(20S)-ginsenoside F1 + H(+) + UDP => (20S)-protopanaxatriol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034798", "l": "fosfomycin 2-L-cysteine ligase activity", "d": ["Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + L-cysteine = hydrogen (1R,2R)-1-L-cysteine-2-hydroxypropylphosphonic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170846", "l": "TGFBR2 recruits TGFBR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839377", "l": "TGFB1,TGFB2 bind TGFBR3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70886", "l": "H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out) <=> H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68777", "l": "(2Z,6Z)-farnesyl diphosphate => diphosphate + germacrene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672177", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55774", "l": "a jasmonyl-L-amino acid + AMP + diphosphate + H(+) => a jasmonate + an L-alpha-amino acid + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.265986832370587", "identifiers": [{"i": "GO:0008017", "l": "microtubule binding", "d": ["Binding to a microtubule, a filament composed of tubulin monomers."], "t": []}, {"i": "REACT:R-HSA-9614343", "l": "Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198669", "l": "p38MAPK phosphorylates MSK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55382", "l": "a 3-oxo bile acid CoA + H(+) + NADH => a 3alpha-hydroxy bile acid CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9609310", "l": "β-blockers bind ADRB1,2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807872", "l": "Active ARF recruits coatomer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36586", "l": "dTDP-alpha-D-fucose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43438", "l": "coproporphyrin III + 3 H2O2 => coproporphyrinogen III + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32676", "l": "alpha,alpha-trehalose + H2O => alpha-D-glucose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30004", "l": "alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose => alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.5", "l": "\"carboxypeptidase C\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58368", "l": "(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) = (2E,6Z)-nona-2,6-dienal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22194", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674531", "l": "AAMP binds EGFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43978", "l": "14-hydroxyhexadecanoate + H2O + NADP(+) => H(+) + hexadecanoate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694441", "l": "CSNK1D phosphorylates SEC23 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78658", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + silphinene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63647", "l": "GDP-beta-L-fucose + L-seryl-[protein] <=> 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77315", "l": "glyoxylate + N(omega),N('omega)-dimethyl-L-arginine = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58085", "l": "1-(13Z-docosenoyl)-glycerol + H2O => (13Z)-docosenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15323", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11490", "l": "an all-trans-retinyl ester + CoA => all-trans-retinol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40365", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102526", "l": "8-demethylnovobiocic acid C8-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 8-desmethylnovobiocic acid = S-adenosyl-L-homocysteine + novobiocic acid + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69410", "l": "androst-4-ene-3,11,17-trione + H(+) + NADH => 11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646685", "l": "Aggresome dissociates from dynein and microtubule (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42781", "l": "adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3240957", "l": "Formation of PRC2-EZH2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40633", "l": "2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate => H2O + trioctadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56149", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphocholine => CoA + hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-398040", "l": "Gbeta:gamma activation of PLC beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940100", "l": "CDK1 phosphorylates VCPIP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60191", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62801", "l": "2 7-demethylsiderin + NADPH + O2 => 2 H2O + NADP(+) + orlandin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70838", "l": "L-arginine(in) + L-glutamine(out) + Na(+)(out) <=> L-arginine(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65553", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => an N-acyl-sphingoid base + lactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38769", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33335", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43876", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA = 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202164", "l": "Translocation of PDK1 to Plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.41", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25293", "l": "ethanol + NAD(+) <=> acetaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34078", "l": "an acyl phosphate + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-381091", "l": "IRE1 dimer autophosphorylates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047436", "l": "arylmalonate decarboxylase activity", "d": ["Catalysis of the reaction: 2-aryl-2-methylmalonate + H+ = 2-arylpropionate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14606", "l": "D-glucose 6-phosphate + GDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.017217500442385", "identifiers": [{"i": "GO:0005253", "l": "monoatomic anion channel activity", "d": ["Enables the energy-independent facilitated diffusion of a monoatomic anion through a transmembrane aqueous pore or channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170149", "l": "Translocation of active Cdc25C to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56573", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose => a globoside Gb3Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71747", "l": "2-oxoglutarate(out) + L-2-aminoadipate(in) = 2-oxoglutarate(in) + L-2-aminoadipate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010314", "l": "phosphatidylinositol-5-phosphate binding", "d": ["Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784189", "l": "JAKs bind LIFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9845587", "l": "ST8SIA5 transfers Neu5Ac to gangliosides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754129", "l": "CDK6 inhibitors bind CDK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74055", "l": "D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63828", "l": "L-alanine + vanillin = pyruvate + vanillylamine", "d": [], "t": []}, {"i": "EC:2.6.1.119", "l": "\"vanillin aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13767", "l": "bromide + chloride + formaldehyde + 2 H(+) => bromochloromethane + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63063", "l": "5-methylorsellinate + ATP + H(+) + NADPH <=> 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800793", "l": "PIDD1 translocates to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51660", "l": "an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 = an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050698", "l": "proteoglycan sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39000", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O => a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.12.1", "l": "\"dual-specificity kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59569", "l": "4-aminobutanoate + ATP + L-histidine => ADP + H(+) + L-homocarnosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694665", "l": "SARS-CoV-2 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.-", "l": "\"Site specific endodeoxyribonucleases: cleavage is not sequence specific\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42237", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57535", "l": "a 5'-end ribonucleotide-RNA + ATP + H(+) <=> a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162195", "l": "COQ4 decarboxylates MHDB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332235", "l": "CBL binds TGFBR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75679", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49140", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:4.2.1.164", "l": "\"dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222412", "l": "lpdC dimer reactivates dlaT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46678", "l": "(6R)-2,2,6-trimethyl-1,4-cyclohexanedione + H(+) + NADH => (4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48965", "l": "2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 => [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848930", "l": "PTK6 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72487", "l": "citrate(out) + phosphoenolpyruvate(in) = citrate(in) + phosphoenolpyruvate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40105", "l": "CoA + H(+) + propanoate => H2O + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43784", "l": "adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.286", "l": "\"25S rRNA (adenine(2142)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71636", "l": "phosphate(in) + 2 thiosulfate(out) => phosphate(out) + 2 thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27500", "l": "3'-O-methyltricetin + S-adenosyl-L-methionine <=> 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25160", "l": "2-oxoglutarate + L-ornithine = L-glutamate + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54678", "l": "(+)-kolavenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74407", "l": "2 (S)-lactate(in) + thromboxane B2(out) = 2 (S)-lactate(out) + thromboxane B2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65437", "l": "a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29162", "l": "3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) <=> 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30957", "l": "7,7',9,9'-tetra-cis-lycopene + 2 a quinol => 9,9'-di-cis-zeta-carotene + 2 a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062181", "l": "1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity", "d": ["Catatlysis of the reaction: calcitriol + 2 H+ + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]."], "t": []}, {"i": "RHEA:49192", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010736", "l": "serum response element binding", "d": ["Binding to a serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66900", "l": "acetyl-CoA + L-tryptophan + malonyl-CoA = CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.-", "l": "\"Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40006", "l": "ent-copalyl diphosphate <=> (Z)-biformene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140347", "l": "N-retinylidene-phosphatidylethanolamine flippase activity", "d": ["Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43808", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33424", "l": "N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) => diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.60", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24074", "l": "12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209973", "l": "Tyrosine is diiodinated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53693", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O => H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59207", "l": "docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53996", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134896", "l": "LRR FLII-interacting protein 1 binds dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177937", "l": "Phosphorylation of EGFR by SRC kinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793472", "l": "RIPK3 binds p-S9-PRKN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48401", "l": "2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62532", "l": "digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigitoxin + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210959", "l": "Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193981", "l": "CYP21A2 oxidises 17HPROG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034480", "l": "phosphatidylcholine phospholipase C activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H+ + phosphocholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36877", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA => (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67506", "l": "1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31371", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine = (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.212", "l": "\"2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24569", "l": "a 6-phospho-beta-D-galactoside + H2O => an alcohol + D-galactose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45515", "l": "phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102524", "l": "tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + O2 + 7-[(3S)-(3-amino-3-carboxypropyl)]-wyosine37 in tRNAPhe = succinate + carbon dioxide + 7-(2-hydroxy-3-amino-3-carboxypropyl)-wyosine37 in tRNAPhe."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706328", "l": "Active FLT3 binds to SOCS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40677", "l": "2-aminobut-2-enoate + H2O => L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186778", "l": "SHP2 binds to the active receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61437", "l": "ADP + H2O => AMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71846", "l": "tauroursodeoxycholate(out) <=> tauroursodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111883", "l": "Hydrolysis of phosphatidylcholine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6802973", "l": "PLK3 phosphorylates CDC25C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015224", "l": "biopterin transmembrane transporter activity", "d": ["Enables the transfer of biopterin from one side of a membrane to the other. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50208", "l": "cortisol + NAD(+) = cortisone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78629", "l": "L-alanine + S-disulfanyl-L-cysteine => L-cysteine + S-sulfanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53134", "l": "a 3-oxo-Delta(1,4)-steroid + AH2 => A + a 3-oxo-Delta(4)-steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46831", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17749", "l": "A + H2O + quinoline = AH2 + quinolin-2(1H)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9909159", "l": "HK1 phosphorylates Mannose to Man6P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26042", "l": "beta-D-fructose 6-phosphate + GDP-alpha-D-mannose <=> beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191072", "l": "Synthesis of Cx43 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10660", "l": "L-seryl-[protein] = D-seryl-[protein]", "d": [], "t": []}, {"i": "EC:5.1.1.16", "l": "\"protein-serine epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73543", "l": "dCDP(out) + UTP(in) = dCDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76534", "l": "H(+) + N-acetyl-S-(2-succino)-L-cysteine + NADH + O2 <=> H2O + N-acetyl-L-cysteine + NAD(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22398", "l": "glycolaldehyde + guaiacol + H2O + vanillin => 1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75772", "l": "(9Z,12Z,15Z)-octadecatrienoate + H2O => (10S)-hydroxy-(12Z,15Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874718", "l": "TTPA binds alpha-TOH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082356", "l": "HSF1-mediated gene expression (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109862", "l": "MAP2K2 phosphorylates MAPK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28460", "l": "biotin(out) => biotin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444047", "l": "Receptor FFAR3 binds carboxylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75766", "l": "(9E,11E)-octadecadienoate + H2O <=> 10-hydroxy-(11E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51043", "l": "indole-3-pyruvate imine dimer <=> chromopyrrolate + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31759", "l": "dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.234", "l": "\"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51087", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391913", "l": "FPR2 binds FPR2 ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69427", "l": "2-hydroxyisobutanoyl-CoA <=> acetone + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247569", "l": "PADI4 deiminates Histones (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29860", "l": "5'-deoxyadenosine + H2O => 5-deoxy-D-ribose + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75534", "l": "AH2 + N-acetyl-S-hydroxy-L-cysteine <=> A + H2O + N-acetyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71504", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in) => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71378", "l": "2 Na(+)(out) + testosterone 17-sulfate(out) <=> 2 Na(+)(in) + testosterone 17-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098616", "l": "selenate adenylyltransferase (ATP) activity", "d": ["Catalysis of the reaction: ATP + H2SeO4 => diphosphate + adenylylselenate."], "t": []}, {"i": "REACT:R-HSA-2408525", "l": "H2SeO4 is converted to APSe by PAPSS1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69661", "l": "beta-D-glucose + kaempferol => H2O + kaempferol 3-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45638", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18116", "l": "a ribonucleoside 5'-diphosphate + ATP <=> a ribonucleoside 5'-triphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28307", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33254", "l": "2 sucrose <=> 6-kestotriose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362522", "l": "ALDHs oxidise atRAL to atRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47336", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421478", "l": "coproporphyrinogen III + 2 O2 => protoporphyrinogen IX + 2 H2O2 + 2 CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032567", "l": "dGTP binding", "d": ["Binding to dGTP, deoxyguanosine triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18551", "l": "[(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP => [(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57353", "l": "O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin => H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58440", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51484", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852337", "l": "GTSE1 binds TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50111", "l": "hexadecanoyl-CoA + taurine <=> CoA + H(+) + N-hexadecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004531", "l": "deoxyribonuclease II activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696358", "l": "TREM,CD300 binds lipids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37441", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56107", "l": "2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 <=> 4,4'-diaponeurosporenal + 2 A + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619803", "l": "p-S516-ARHGEF7 activates RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654625", "l": "Activated FGFR3 binds SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65994", "l": "5,6-trans-vitamin D3 => calciol + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33214", "l": "1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-7 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16218", "l": "H2O + L-arabinono-1,4-lactone => H(+) + L-arabinonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77700", "l": "a ganglioside GD1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GT1balpha  (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39350", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH <=> (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78639", "l": "acetyl-CoA + tetracosanoyl-CoA = 3-oxohexacosanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43530", "l": "2-aminomalonate semialdehyde + H(+) + NADH => L-serine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55543", "l": "40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] <=> 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24504", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.54", "l": "\"acireductone dioxygenase (Fe(2+)-requiring)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443783", "l": "Interaction of NUMB with L1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47017", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O => [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72194", "l": "cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050141", "l": "nitroethane oxidase activity", "d": ["Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14498", "l": "A + pyridoxine => AH2 + isopyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9698844", "l": "MLKL binds HSP90:CDC37 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47010", "l": "[DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite => [DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050009", "l": "isopropanol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + propan-2-ol = acetone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20696", "l": "2 H(+) + 2 superoxide = H2O2 + O2", "d": [], "t": []}, {"i": "EC:1.15.1.1", "l": "\"superoxide dismutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804379", "l": "PRMT5 binds TTC5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168641", "l": "TAK1 associated with the CBM complex phosphorylates IKKbeta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033800", "l": "isoflavone 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18685", "l": "H(+) + NADPH + O2 + pentachlorophenol = 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626938", "l": "Beta-catenin binds SOX proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72872", "l": "anthocyanin A3 + malonyl-CoA => anthocyanin A5 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77950", "l": "1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate <=> 1,3-di-(10Z-heptadecenoyl)-glycerol + 9-(10Z-heptadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78491", "l": "CMP-5'-(3-aminopropyl)phosphonate + NADPH + O2 = CMP-5'-(N-hydroxy-3-aminopropyl)phosphonate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450325", "l": "c-FOS activation by phospho ERK1/2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30348", "l": "ATP + IDP => ADP + ITP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73159", "l": "FMN(out) + NAD(+)(in) = FMN(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792491", "l": "TP53 stimulates CCNG1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806974", "l": "MET dimers autophosphorylate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48161", "l": "3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] => epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75701", "l": "glutathione disulfide + H(+) + NADH => 2 glutathione + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63095", "l": "H(+) + ilicicolin A + NADPH + O2 <=> H2O + ilicicolin A epoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685607", "l": "Sialic acid binds SIGLEC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944263", "l": "Association of procollagen type II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23983", "l": "cyclomaltodextrin + H2O <=> linear maltodextrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56968", "l": "dCTP + pyruvate = dCDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44664", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24193", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) => (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47981", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55249", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48205", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA => (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75561", "l": "cyathadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => erinacol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72575", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O = (22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64300", "l": "3-phenylpropylamine + pyruvate = 3-phenylpropanal + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043782", "l": "cobalt-precorrin-3 C17-methyltransferase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0070513", "l": "death domain binding", "d": ["Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58586", "l": "(-)-tabersonine + acetate + H(+) => dihydroprecondylocarpine acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112437", "l": "Formation of NELF complex  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18157", "l": "ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689000", "l": "AADAC deacetylates PHEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9840564", "l": "OMA1 hydrolyzes YME1L1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51221", "l": "1-chloro-2,4-dinitrobenzene + glutathione => 2,4-dinitrophenyl-S-glutathione + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48384", "l": "a 2,3-saturated fatty acid + H2O2 = a 3-hydroxy fatty acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0015080", "l": "silver ion transmembrane transporter activity", "d": ["Enables the transfer of silver (Ag+) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40852", "l": "FAD + H(+) + pentadecanoyl-CoA => (2E)-pentadecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55572", "l": "4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine = 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53106", "l": "4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine => 4-hydroxyestrone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29675", "l": "glycerol(in) = glycerol(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70684", "l": "(R)-normetanephrine + S-adenosyl-L-methionine => (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23261", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114419", "l": "Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67171", "l": "2-oxoglutarate + 3-hydroxy-L-phenylalanine <=> 3-(3-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30954", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> alpha-eudesmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63537", "l": "bradykinin(1-8) + H2O => bradykinin(1-7) + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71403", "l": "2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] = 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39298", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806610", "l": "Keratin filament formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74896", "l": "nitric oxide(out) => nitric oxide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17179", "l": "CoA + O-octanoyl-(R)-carnitine => (R)-carnitine + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19703", "l": "a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP => a flavonol 3-O-glycoside + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24263", "l": "(3E)-2-oxohex-3-enedioate + H(+) <=> 2-oxopent-4-enoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9623384", "l": "α1-agonists bind ADRA1A,B,D (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43484", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755304", "l": "MUL1 ubiquitinates UBXN7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430183", "l": "NCK binds PAK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11682", "l": "AMP + diphosphate + GMP + 2 H(+) + L-glutamate => ATP + H2O + L-glutamine + XMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47297", "l": "dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12352", "l": "L-gulono-1,4-lactone + O2 = H2O2 + L-xylo-hex-3-ulonolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42612", "l": "a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9864415", "l": "AAC1 imports a proton (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38441", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15684", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) <=> (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16974", "l": "2-hydroxypyridine + AH2 + O2 => 2,5-dihydroxypyridine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0042302", "l": "structural constituent of cuticle", "d": ["The action of a molecule that contributes to the structural integrity of a cuticle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236947", "l": "Egress of internalized antigen to the cytosol via sec61 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20928", "l": "[DsbA protein]-dithiol + a quinone = [DsbA protein]-disulfide + a quinol", "d": [], "t": []}, {"i": "EC:1.8.5.9", "l": "\"protein dithiol:quinone oxidoreductase DsbB\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801776", "l": "REG3A binds bacterial phospholipids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46884", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50335", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11854", "l": "adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate => phosphate + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981606", "l": "Myoglobin binds oxygen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0061783", "l": "peptidoglycan muralytic activity", "d": ["A catalytic activity that contributes to the degradation of peptidoglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35794", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin X + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102046", "l": "3,4-dichlorobenzoate-4,5-oxygenase activity", "d": ["Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor = 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42795", "l": "cholesterol + hexadecanoyl-CoA <=> cholesteryl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9865449", "l": "Metallochaperone inserts Cu2+ into MT-CO1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30500", "l": "H(+) + N,N-dihydroxy-L-valine => (E)-2-methylpropanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34214", "l": "ecgonine methyl ester + NADP(+) <=> ecgonone methyl ester + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44808", "l": "1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) = 2-demethylmenaquinol-10 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75132", "l": "neomorphinone => morphinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651773", "l": "LIG1 binds POLB at long-patch BER site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69805", "l": "benzoyl-AMP + diphosphate => ATP + benzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674022", "l": "BRAP autoubiquitinates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77039", "l": "4-hydroxyhexan-3-amine + H2O + NAD(+) = 4-hydroxyhexan-3-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72402", "l": "2-oxoglutarate(out) + estrone 3-sulfate(in) <=> 2-oxoglutarate(in) + estrone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807106", "l": "PTEN undergoes monoubiquitination (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50439", "l": "prostaglandin H1 <=> prostaglandin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009936", "l": "RNASEL cleaves cellular ssRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72042", "l": "nicotinate(in) + orotate(out) <=> nicotinate(out) + orotate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607058", "l": "Activated protein C:PROCR binds F2R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11601", "l": "ATP + CMP => ADP + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28135", "l": "(2S)-hesperidin + H2O => (2S)-hesperetin + rutinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27363", "l": "chloromethane + S-adenosyl-L-homocysteine => chloride + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59394", "l": "CoA + O-acetyl-L-seryl-[protein] => acetyl-CoA + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168459", "l": "Lyn activates ERK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0000224", "l": "peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity", "d": ["Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39285", "l": "a long-chain fatty acid(in) => a long-chain fatty acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56194", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28639", "l": "(2Z,6E)-farnesyl diphosphate = (-)-gamma-cadinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.62", "l": "\"(-)-gamma-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-139941", "l": "Binding of IP3 to IP3 receptor (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78742", "l": "(3S)-hydroxyoctadecanoyl-CoA + NAD(+) <=> 3-oxooctadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74121", "l": "delphinidin 3-O-beta-D-galactoside + H(+) + UDP => delphinidin + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75825", "l": "5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase] => (5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43551", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59646", "l": "D-xylobionate + H(+) => D-xylobiono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13637", "l": "H(+) + methane + NADH + O2 = H2O + methanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55375", "l": "H2O + methyl (-)-jasmonate <=> H(+) + jasmonate + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11782", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70891", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(out) = L-asparagine(in) + L-glutamine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021068", "l": "PalmS-ESRs bind CAVs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005166", "l": "neurotrophin p75 receptor binding", "d": ["Binding to a neurotrophin p75 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015660", "l": "formate efflux transmembrane transporter activity", "d": ["Enables the transfer of formate from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47870", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => di-(9Z)-octadecenoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "46.122660258685926", "identifiers": [{"i": "GO:0005216", "l": "monoatomic ion channel activity", "d": ["Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209257", "l": "Phosphorylated REL-68 forms a complex with PCAF at its target gene and activates transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63556", "l": "dynorphin A-(1-13) + H2O = dynorphin A-(1-12) + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69462", "l": "[thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine => [thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791144", "l": "Expression of EXTL3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609310", "l": "β-blockers bind ADRB1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693608", "l": "Initial resection of double-strand break ends (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "65.330057800181052", "identifiers": [{"i": "GO:0016811", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168923", "l": "Collagen type XVIII endostatin release (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65691", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862771", "l": "PLA2G2A binds bacterial phospholipids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-213406", "l": "Disassociation of PLC-gamma1 from LAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33088", "l": "cyclic dehypoxanthinylfutalosinate => 1,4-dihydroxy-6-naphthoate + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31545", "l": "2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside) => all-trans-zeaxanthin + 2 UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36554", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol <=> 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015188", "l": "L-isoleucine transmembrane transporter activity", "d": ["Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55980", "l": "a 1,2-saturated acyl-CoA + an acyl-CoA + H2O = an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.20", "l": "\"acyl-CoA:acyl-CoA alkyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538891", "l": "CLK:CYC heterodimer dissociates from per, tim, vri, and Pdp1 genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40504", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37155", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77307", "l": "N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52756", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693536", "l": "ATM phosphorylates MDC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78894", "l": "6-O-methyl-N-deacetylisoipecoside + H2O <=> 6-O-methyl-N-deacetylisoipecoside aglycone + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70588", "l": "H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) => acetate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48931", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168923", "l": "Collagen type XVIII endostatin release (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45263", "l": "tetracosanoate(out) <=> tetracosanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68707", "l": "3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate) <=> 3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67451", "l": "(2R)-2-hydroxyoctadecanoyl-CoA <=> formyl-CoA + heptadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49014", "l": "aurachin C epoxide + H2O + NAD(+) => aurachin C + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004814", "l": "arginine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31015", "l": "H(+) + indole-3-carboxylate = CO2 + indole", "d": [], "t": []}, {"i": "EC:4.1.1.92", "l": "\"indole-3-carboxylate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73391", "l": "H(+)(in) + phosphate(in) + sulfate(out) = H(+)(out) + phosphate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001874", "l": "(1->3)-beta-D-glucan immune receptor activity", "d": ["Combining with (1->3)-beta-D-glucans to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372697", "l": "Crk binding to p130cas (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69990", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+) <=> (22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-532549", "l": "MPI isomerises Fru6P to Man6P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048257", "l": "3'-flap endonuclease activity", "d": ["Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43458", "l": "(2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.213", "l": "\"cytidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031804", "l": "type 7 metabotropic glutamate receptor binding", "d": ["Binding to a type 7 metabotropic glutamate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14055", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate => D-arabinose 5-phosphate + H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004458", "l": "D-lactate dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15173", "l": "H(+) + H2O2 + NADPH = 2 H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.11.1.2", "l": "\"NADPH peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76263", "l": "ergothioneine(in) = ergothioneine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29240", "l": "H(+)(in) + uracil(in) => H(+)(out) + uracil(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21843", "l": "N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "47.807973361987038", "identifiers": [{"i": "GO:0016491", "l": "oxidoreductase activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021596", "l": "Membrane estrogen receptors bind SRC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686587", "l": "ABL1 phosphorylates RAD52 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10955", "l": "(E)-sinapoyl-CoA + hydroxymalonate <=> (E)-sinapoyltartronate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2197690", "l": "Detachment of WASP/WAVE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58943", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH <=> all-trans-lycopaoctaene + diphosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69294", "l": "goitrin + sulfate => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49851", "l": "(-)-dehydrodiconiferyl acid ketone + a quinone + H2O <=> (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18512", "l": "H(+) + H2O2 + NADH <=> 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19631", "l": "2-oxoglutarate + CO2 + NADPH => D-threo-isocitrate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19893", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP", "d": [], "t": []}, {"i": "EC:2.7.4.7", "l": "\"phosphooxymethylpyrimidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17449", "l": "(2E)-geranyl diphosphate + flaviolin = 3-linalylflaviolin + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.123", "l": "\"flaviolin linalyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251559", "l": "Deletions of the AMER1 gene prevent expression of AMER1 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019177", "l": "dihydroneopterin triphosphate pyrophosphohydrolase activity", "d": ["Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227709", "l": "Activated MDA5 binds IPS-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432510", "l": "CLK is degraded by the 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218832", "l": "CDC42:GTP binds PAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35137", "l": "L-alanyl-L-glutamate(in) => L-alanyl-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.105", "l": "\"monocyclic monoterpene ketone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483087", "l": "PI is exchanged with PC by PITPNB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-606349", "l": "Mis18 complex binds the centromere (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964280", "l": "Active Gq binds BTK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000074", "l": "TCN2 binds RCbl in the circulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55272", "l": "11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990447", "l": "U2 snRNP binding", "d": ["Binding to a U2 small nuclear ribonucleoprotein particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867344", "l": "OMA1 hydrolyses OPA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44435", "l": "2 a 1-acylglycerol <=> a 1,2-diacylglycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11938", "l": "4 CO2 + 4 CoA + trans-resveratrol => 4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621371", "l": "CLEC4C binds HIV and HCV glycoproteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12302", "l": "3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine + uridine(47) in tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29290", "l": "2 H(+)(in) + L-aspartate(in) <=> 2 H(+)(out) + L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30857", "l": "(S)-2,3-epoxysqualene + H2O => dammarenediol-II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64473", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine => (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198714", "l": "ERK5 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76278", "l": "Na(+)(out) + uracil(out) <=> Na(+)(in) + uracil(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2423785", "l": "CR:atREs binds apoE and HSPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111970", "l": "PKC phosphorylates GRK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49508", "l": "phosphinomethylmalate = 2-(phosphinatomethylidene)butanedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082356", "l": "HSF1-mediated gene expression (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10783", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49676", "l": "H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 = H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18361", "l": "a dolichyl D-xylosyl phosphate + L-seryl-[protein] = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.4.2.33", "l": "\"dolichyl-xylosyl-phosphate--protein xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42723", "l": "S-adenosyl-L-methionine + uridine(2552) in 23S rRNA <=> 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757686", "l": "SERPINA6 binds PREDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38038", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate <=> (4Z)-2-oxohept-4-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77589", "l": "Recognition of AAUAAA sequence by CPSF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174235", "l": "Association of Emi1 with Cdc20 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010427", "l": "abscisic acid binding", "d": ["Binding to abscisic acid, a plant hormone that regulates aspects of plant growth."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76297", "l": "methylcob(III)alamin + S-adenosyl-L-homocysteine => cob(I)alamin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36552", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol => 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0004784", "l": "superoxide dismutase activity", "d": ["Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874195", "l": "MBTPS2 (S2P) cleaves CREB3L4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.296", "l": "\"omega-hydroxyceramide transacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56221", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78267", "l": "H2O + omega-dicarboxyl-CoA = a dicarboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627369", "l": "SEPT4 binds XIAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928639", "l": "p-EFNB binds GRB4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32639", "l": "(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211968", "l": "CYP2W1 oxidises INDOL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56229", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine => (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62130", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + dGDP => a 2'-deoxyribonucleoside 5'-phosphate + dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29989", "l": "adenosine(out) + H(+)(out) => adenosine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009558", "l": "IL34 dimer binds SDC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35294", "l": "11-methyldodecanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxoisopentadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450488", "l": "BRF1 Complex recruits RNA degradation activities (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40161", "l": "NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose => H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43432", "l": "butan-1-ol + 2 Fe(III)-[cytochrome c] = butanal + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.1.2.9", "l": "\"1-butanol dehydrogenase (cytochrome c)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835328", "l": "NPM binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45676", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54194", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => L-lysyl-[protein] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13726", "l": "acetyl-CoA + alpha-D-glucosamine 1-phosphate => CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848110", "l": "SOCS3 binds activated PTK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043777", "l": "cobalt-precorrin-7 C15-methyltransferase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28048", "l": "CoA + propanoyl phosphate => phosphate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66762", "l": "ADP + H(+) + kainate(out) + phosphate => ATP + H2O + kainate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78651", "l": "ATP + S-disulfanyl-L-cysteine + tRNA(Cys) = (S)-disulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197691", "l": "WIP binds WASP,N-WASP, activating them (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429036", "l": "SLC2A9 transports Fru, Glc, urate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62289", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate => (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70573", "l": "argininosuccinate <=> fumarate + arginine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380574", "l": "Dopamine synaptic vesicle docking and priming (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18419", "l": "a ganglioside GM3 (d18:1(4E)) + CMP + H(+) => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130151", "l": "Dimerization of DAP12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55432", "l": "11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.61", "l": "\"carnosic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11713", "l": "3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381608", "l": "cAMP activates EPAC2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944246", "l": "Association of procollagen type XXI (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72697", "l": "Start codon recognition (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12529", "l": "N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate => [hyaluronan](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22475", "l": "(R)-pantetheine + ATP <=> (R)-4'-phosphopantetheine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187266", "l": "SCARA5 binds ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165179", "l": "Formation of TSC1:TSC2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193702", "l": "Part of the ICD migrates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46210", "l": "AMP + diphosphate + eicosanoyl-CoA => ATP + CoA + eicosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23796", "l": "17-O-acetylnorajmaline + H2O = acetate + H(+) + norajmaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005497", "l": "androgen binding", "d": ["Binding to an androgen, a male sex hormone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58156", "l": "ATP + H2O + 4 Na(+)(in) = ADP + H(+) + 4 Na(+)(out) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.1", "l": "\"Na(+)-transporting two-sector ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15556", "l": "1D-myo-inositol 1,4-bisphosphate + H2O <=> 1D-myo-inositol 4-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58424", "l": "(E)-hex-2-en-1-ol + NADP(+) = (E)-hex-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724291", "l": "Defective ALG6 does not add glucose to the N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080017", "l": "alpha-humulene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-humulene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67030", "l": "(glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate => (glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.152", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031881", "l": "type 4 somatostatin receptor binding", "d": ["Binding to a type 4 somatostatin receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70640", "l": "H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497794", "l": "Salvage - BH2 is reduced to BH4 by DHFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170846", "l": "TGFBR2 recruits TGFBR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006870", "l": "IL21 receptor STAT phosphorylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674140", "l": "PAQR3 binds inactive RAFs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646354", "l": "PolyUb-Misfolded Proteins:HDAC6 dissociate from complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45607", "l": "D-glucaro-1,4-lactone <=> 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31306", "l": "a reduced flavin + NAD(+) <=> an oxidized flavin + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050252", "l": "retinol O-fatty-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696274", "l": "RND1 binds GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928620", "l": "PAK1 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76200", "l": "oxalate(in) => oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.8.-", "l": "\"With a flavin as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65186", "l": "berkeleyone B + CO2 + H2O + succinate => 2-oxoglutarate + O2 + preaustinoid A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31501", "l": "a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59311", "l": "D-galactono-1,5-lactone + H2O <=> D-galactonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033752", "l": "acetylacetone-cleaving enzyme activity", "d": ["Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825631", "l": "MESP2 binds the RIPPLY2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66710", "l": "2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63206", "l": "H(+) + holo-[ACP] + octadecanoate => H2O + octadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74411", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66846", "l": "asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11292", "l": "2 H(+) + O2 + rifamycin B = H2O2 + rifamycin O", "d": [], "t": []}, {"i": "EC:1.10.3.6", "l": "\"rifamycin-B oxidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15798", "l": "(4Z,15Z)-bilirubin IXalpha + NAD(+) => biliverdin IXalpha + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647978", "l": "pro-RAS proteins are farnesylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036402", "l": "proteasome-activating activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome."], "t": []}, {"i": "EC:5.6.1.5", "l": "\"proteasome ATPase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15763", "l": "H(+) + L-aspartate 4-semialdehyde + NADPH => L-homoserine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69797", "l": "D-aspartate + H(+) + tRNA(Asp) => D-aspartyl-tRNA(Asp) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63730", "l": "candesartan-2-N-beta-D-glucuronide + UDP => candesartan + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28322", "l": "UDP-alpha-D-glucuronate + wogonin = UDP + wogonin 7-O-beta-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59172", "l": "hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] = AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72553", "l": "glutarate(in) + urate(out) => glutarate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60956", "l": "17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30768", "l": "D-glucurono-3,6-lactone + H2O => D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.39", "l": "\"alkylglycerophosphoethanolamine phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29818", "l": "ATP + H2O + L-proline(out) <=> ADP + H(+) + L-proline(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983424", "l": "Budding of COPII coated vesicle (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205244", "l": "Recruitment of CBL to KIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433711", "l": "Cis-homodimerization of nectins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14722", "l": "UDP-alpha-D-xylose + zeatin => H(+) + O-beta-D-xylosylzeatin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35177", "l": "novobiocin(out) => novobiocin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102944", "l": "medicagenate UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + medicagenate = UDP(3-) + a medicagenate monoglucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0017128", "l": "phospholipid scramblase activity", "d": ["Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654533", "l": "KRAS4B recycles to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16406", "l": "benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) => benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69712", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O => beta-D-glucose + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32259", "l": "beta-D-fructose 1-phosphate + methylglyoxal = 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16105", "l": "a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27761", "l": "(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015567", "l": "alkane transmembrane transporter activity", "d": ["Enables the transfer of alkanes from one side of a membrane to the other. Alkanes are saturated aliphatic hydrocarbon compounds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54032", "l": "(6R)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201611", "l": "Caspase-mediated cleavage of Rock-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68611", "l": "Formation of ORC(1-5) complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47758", "l": "2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54052", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + tau-cadinol", "d": [], "t": []}, {"i": "EC:4.2.3.173", "l": "\"tau-cadinol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39818", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate <=> (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8963864", "l": "CUBN dissociates from 25(OH)D (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42757", "l": "cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757954", "l": "N4BP1 binds IKBKG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63846", "l": "2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O => [thioredoxin]-dithiol + cumene hydroperoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35887", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000327", "l": "PLK1 phosphorylates BORA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035954", "l": "Defective CYP17A1 does not 17-hydroxylate P4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19902", "l": "L-tryptophan + O2 => alpha,beta-didehydrotryptophan + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62199", "l": "2 Fe(III)-[cytochrome c] + propan-2-ol <=> acetone + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19177", "l": "L-lysine = (3S)-3,6-diaminohexanoate", "d": [], "t": []}, {"i": "EC:5.4.3.2", "l": "\"lysine 2,3-aminomutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52262", "l": "a bacteriochlorophyllide e + H2O => a 7(1),7(1)-dihydroxybacteriochlorophyllide c", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9856718", "l": "HPDL dioxygenates HPPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624798", "l": "LBR binds KPNB1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22269", "l": "ATP + streptomycin => ADP + H(+) + streptomycin 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21494", "l": "catechol + CO2 => 2,3-dihydroxybenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57566", "l": "7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77116", "l": "1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O => 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22292", "l": "benzoyl-CoA + 3 H(+) + 3 malonyl-CoA = biphenyl-3,5-diol + 4 CO2 + 4 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.177", "l": "\"3,5-dihydroxybiphenyl synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803892", "l": "SFN dimer binds BAX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0047929", "l": "gluconate dehydratase activity", "d": ["Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814409", "l": "CK2 phosphorylates PDCL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17425", "l": "CoA + NADP(+) + pyruvate = acetyl-CoA + CO2 + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.51", "l": "\"pyruvate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77567", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,3-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018334", "l": "Estrogen-responsive CXXC5 gene expresion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187575", "l": "Ubiquitination of phospho-p27/p21 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782820", "l": "USP17 deubiquitinates SUDS3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050397", "l": "Watasenia-luciferin 2-monooxygenase activity", "d": ["Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27435", "l": "glutathione amide disulfide + H(+) + NADH => 2 glutathione amide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.773497473658765", "identifiers": [{"i": "GO:0022884", "l": "macromolecule transmembrane transporter activity", "d": ["Enables the transfer of a macromolecule from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35098", "l": "choline <=> acetaldehyde + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9844006", "l": "SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20960", "l": "1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27499", "l": "3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine => 3'-O-methyltricetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858932", "l": "MITF-M-dependent ATP6V0D1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46734", "l": "(2S,6)-dimethylheptanoyl-CoA => (2R,6)-dimethylheptanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981539", "l": "C3b binds to cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58468", "l": "2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 = 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0016805", "l": "dipeptidase activity", "d": ["Catalysis of the hydrolysis of a dipeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70486", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2 <=> a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10017", "l": "H2O + O-sinapoylcholine => (E)-sinapate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67196", "l": "H2O + N-acetylserotonin = acetate + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67261", "l": "(E)-hept-2-enal + H2O + NAD(+) => (E)-hept-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45855", "l": "Co(II)-factor III + H(+) + S-adenosyl-L-methionine <=> Co(II)-factor IV + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19165", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose = 1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.208", "l": "\"diglucosyl diacylglycerol synthase (1,2-linking)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54279", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 <=> (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26088", "l": "(4S)-limonene + H(+) + NADPH + O2 <=> H2O + limonene 1,2-epoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14452", "l": "chlorophyllide a + NADP(+) <=> 3,8-divinyl chlorophyllide a + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27993", "l": "1-deoxy-D-xylulose + ATP <=> 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.48", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799431", "l": "TP53 binds HIPK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869580", "l": "DEK binds TFAP2A homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21825", "l": "2-oxoglutarate + L-aspartate => L-glutamate + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44504", "l": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24672", "l": "H(+) + NADH + xanthine => H2O + hypoxanthine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27657", "l": "2-oxobutanoate + H(+) + pyruvate <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72691", "l": "Formation of the 43S pre-initiation complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.46", "l": "\"complement factor D\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237119", "l": "Acireductone is oxidized to MOB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65214", "l": "(2E)-dodecenoate + CoA + H(+) => (2E)-dodecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5618107", "l": "ATP binding to HSP90 triggers conformation change (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9796053", "l": "PRKCI phosphorylates NFE2L2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56459", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 12-epi-fischerindole U", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674018", "l": "BRAP binds RAS:GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018855", "l": "2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity", "d": ["Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658430", "l": "NF1 is degraded by the proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62166", "l": "D-glucosamine + N-acetyl-D-glucosamine => beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667619", "l": "AVPR1A,B,2 bind atosiban (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31169", "l": "3-oxotetradecanoyl-CoA + H(+) + NADH => (3S)-hydroxytetradecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654533", "l": "KRAS4B recycles to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70200", "l": "dopaminechrome => 5,6-dihydroxyindole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007539", "l": "CHEK1 phosphorylates E2F6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40859", "l": "(9Z)-hexadecenoyl-CoA + FAD + H(+) = (2E,9Z)-hexadecadienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.20", "l": "\"long-chain-alcohol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635915", "l": "ATF4 and CEBPB,CEBPG bind the ASNS gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51607", "l": "2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74498", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B <=> yaequinolone C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70662", "l": "H(+)(in) + N,N-dimethylglycine(in) <=> H(+)(out) + N,N-dimethylglycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13052", "l": "D-glucuronate <=> D-fructuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694261", "l": "nsp9 forms a homotetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72994", "l": "2 Na(+)(out) + scyllo-inositol(out) <=> 2 Na(+)(in) + scyllo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51005", "l": "a primary alcohol + 2 Fe(III)-[cytochrome cL] => an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047703", "l": "beta-nitroacrylate reductase activity", "d": ["Catalysis of the reaction: 3-nitropropanoate + NADP+ = 3-nitroacrylate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693012", "l": "TNFSF15 binds TNFRSF25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624956", "l": "PDE6D binds INPP5E (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60834", "l": "a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate => a 5'-end triphospho-guanosine in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928639", "l": "p-EFNB binds GRB4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14001", "l": "choloyl-CoA + glycine = CoA + glycocholate + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.65", "l": "\"bile acid-CoA:amino acid N-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102453", "l": "anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + H+ + an anthocyanidin-3-O-beta-D-glucoside = coenzyme A + H+ + an anthocyanidin-3-O-[6-O-(hydroxycinnamoyl)-beta-D-glucoside]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070064", "l": "proline-rich region binding", "d": ["Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52397", "l": "4-O-phospho-D-threonate + NAD(+) => CO2 + dihydroxyacetone phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047809", "l": "D-2-hydroxy-acid dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-lactate + A = AH(2) + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727188", "l": "ATP4A:ATP4B binds PPIs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37642", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19690", "l": "L-rhamnulose 1-phosphate => (S)-lactaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0015464", "l": "acetylcholine receptor activity", "d": ["Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0140035", "l": "ubiquitin-like protein reader activity", "d": ["A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9681616", "l": "AP2 binds chlorpromazine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814764", "l": "Plasma membrane resorption (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444100", "l": "PROT mediates L-proline uptake (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30010", "l": "ATP + H2O + L-arabinose(out) <=> ADP + H(+) + L-arabinose(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65213", "l": "(2E)-dodecenoyl-CoA + H2O => (2E)-dodecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48499", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43185", "l": "S-adenosyl-L-methionine + uridine(2843) in 25S rRNA => H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63012", "l": "(2E,6E)-farnesyl diphosphate + orsellinate = diphosphate + ilicicolinate B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549322", "l": "OCT1 transports organic cations out of hepatic cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38267", "l": "2-methylfumaryl-CoA = 3-methylfumaryl-CoA", "d": [], "t": []}, {"i": "EC:5.4.1.3", "l": "\"2-methylfumaryl-CoA isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50662", "l": "2-(2-methylsulfanyl)propylmaleate + H2O => 3-(3-methylsulfanyl)propylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.16", "l": "\"4-hydroxy-2-oxoglutarate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67054", "l": "A + asnovolin A + H2O => AH2 + asnovolin J + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13741", "l": "3-phenylpyruvate + L-tryptophan = indole-3-pyruvate + L-phenylalanine", "d": [], "t": []}, {"i": "EC:2.6.1.28", "l": "\"tryptophan--phenylpyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939667", "l": "ITGA5 gene expression is stimulated by RUNX2:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983421", "l": "Journey of cargo through Golgi complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19225", "l": "glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": [], "t": []}, {"i": "EC:1.97.1.4", "l": "\"[formate-C-acetyltransferase]-activating enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786190", "l": "CMBL hydrolyses OM to OLMS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047157", "l": "myelin-proteolipid O-palmitoyltransferase activity", "d": ["Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52288", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13317", "l": "(2R,3R)-tartrate + H(+) = (R)-glycerate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.73", "l": "\"tartrate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9650165", "l": "ASIC trimers bind H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35740", "l": "cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] => 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909780", "l": "(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65886", "l": "H2O + L-glutamate + xanthurenate => 2-oxoglutarate + 3-hydroxy-L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1474266", "l": "Formation of collagen fibrils (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67115", "l": "L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692236", "l": "DMRT1 binds the FOXL2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785594", "l": "FANCD2 binds FANCI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30447", "l": "3-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854981", "l": "SHC1 in the RET complex is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41920", "l": "3-oxooctadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42149", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36867", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70673", "l": "CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein] => N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71864", "l": "taurodeoxycholate(out) => taurodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40364", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11440", "l": "2,3,5,6-tetrachlorophenol + NADPH + O2 = 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38366", "l": "1-octadecanoylglycerol + H2O <=> glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53515", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19061", "l": "H2O + NADP(+) + nitrite = H(+) + NADPH + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676254", "l": "Formation of the MLL3 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22700", "l": "gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419166", "l": "GEFs activate RhoA,B,C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.28", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033945", "l": "oligoxyloglucan reducing-end-specific cellobiohydrolase activity", "d": ["Catalysis of the hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-(1->4) linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.5", "l": "\"tyrosine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62246", "l": "a cytidine-thymine dinucleotide in DNA => a cytidine(6-4)thymidine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57420", "l": "NADH + 2 oxidized [cytochrome P450] = H(+) + NAD(+) + 2 reduced [cytochrome P450]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13630", "l": "(1S,5R)-carveol + NADP(+) => (R)-carvone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68595", "l": "ORC2 binds ORC3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56416", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate = alpha-D-glucose 1-phosphate + glycerol", "d": [], "t": []}, {"i": "EC:2.4.1.359", "l": "\"glucosylglycerol phosphorylase (configuration-retaining)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53031", "l": "lithocholate + UDP-alpha-D-glucuronate <=> H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928645", "l": "EPHB:NMDAR binds TIAM1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.-.-", "l": "\"Transferring aldehyde or ketonic groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-425861", "l": "Activation of Protein Kinase C novel isoforms (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13716", "l": "a ubiquinone + succinate <=> a ubiquinol + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69228", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate = an epithionitrile + sulfate", "d": [], "t": []}, {"i": "EC:4.8.1.6", "l": "\"N-(sulfonatooxy)alkenimidothioic acid sulfate-lyase (epithionitrile-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66024", "l": "hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172123", "l": "Interaction of SIGLEC14/15/16 and DAP12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0030171", "l": "voltage-gated proton channel activity", "d": ["Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10953", "l": "(E)-sinapoyl-CoA + hydroxymalonate => (E)-sinapoyltartronate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77403", "l": "2-methylpropanal + hydrogen cyanide = (2S)-2-hydroxy-3-methylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061712", "l": "tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase", "d": ["Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14263", "l": "6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA => (E)-sinapoyl-CoA + D-glucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783530", "l": "gp130:JAKs bind CNTFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77441", "l": "a ganglioside GT1c + N-acetylneuraminate => a ganglioside GQ1c + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202222", "l": "Phosphorylation of PKC theta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209566", "l": "TRAF6 is auto-ubiquitinated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53120", "l": "(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) = 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.36", "l": "\"aldose-1-phosphate adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635854", "l": "GLI2,3 are degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57269", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP => GMP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48664", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015119", "l": "hexose phosphate transmembrane transporter activity", "d": ["Enables the transfer of hexose phosphate from one side of a membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018754", "l": "GDIs bind RHOH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706350", "l": "FLT3 phosphorylates CBL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76788", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] => 1,10-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24555", "l": "5alpha-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71801", "l": "Ca(2+)(out) + H(+)(in) => Ca(2+)(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62161", "l": "H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate => N-(9Z-octadecenoyl) ethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0042013", "l": "interleukin-19 binding", "d": ["Binding to interleukin-19."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031836", "l": "neuromedin K receptor binding", "d": ["Binding to a neuromedin K receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77634", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol <=> 1-tetradecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707586", "l": "FeHM oxidises LDL,HDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74763", "l": "rhamnetin + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65386", "l": "(N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682011", "l": "LC3 binds ATG7 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450387", "l": "HuR binds the CRM1 nuclear export machinery (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57691", "l": "apo-[corrinoid adenosyltransferase] + cob(II)inamide <=> cob(II)inamide-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34581", "l": "2 CO2 + H2O + pentalenolactone F + 2 succinate => 2 2-oxoglutarate + 2 O2 + pentalenolactone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61161", "l": "quercetin + UDP-beta-L-rhamnose => H(+) + quercitrin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012835", "l": "GDIs block activation of RHOA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050588", "l": "apo-beta-carotenoid-14',13'-dioxygenase activity", "d": ["Catalysis of the reaction: 8'-apo-beta-carotenol + O2 = (E,E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019150", "l": "D-ribulokinase activity", "d": ["Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18337", "l": "D-ribose 5-phosphate + uracil = H2O + psi-UMP", "d": [], "t": []}, {"i": "EC:4.2.1.70", "l": "\"pseudouridylate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74423", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59385", "l": "2-oxoglutarate + 4-amino-L-phenylalanine => 3-(4-aminophenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44138", "l": "CoA + hexadecanyl dodecanoate => dodecanoyl-CoA + hexadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450474", "l": "MK2 phosphorylates BRF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102100", "l": "mycothiol-arsenate ligase activity", "d": ["Catalysis of the reaction: arsenate + mycothiol = mycothiol-arsenate conjugate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426153", "l": "SREBP1A,1C binds the ACACB promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9838035", "l": "CLPXP binds mitochondrial matrix proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420883", "l": "Opsins act as GEFs for G alpha-t (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68659", "l": "7-oxocholesterol + H(+) + NADPH <=> 7beta-hydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641206", "l": "RSPOs bind LGRs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16139", "l": "3''-deamino-3''-oxonicotianamine + H(+) + NADPH => 2'-deoxymugineate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17612", "l": "L-seryl-[sulfatase] + S-adenosyl-L-methionine <=> 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16114", "l": "2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) => 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389354", "l": "Activation of Vav1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685605", "l": "SLAMF7 binds SLAMF7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36318", "l": "2 H(+) + hexadecanoyl-CoA + 2 NADPH <=> CoA + hexadecan-1-ol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39681", "l": "3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA => (11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140696", "l": "factor V -> factor Va + factor V activation peptide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14229", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.5.7.1", "l": "\"methylenetetrahydrofolate reductase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34971", "l": "Fe(3+)(in) = Fe(3+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45048", "l": "acetamide + H2O = acetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71998", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + preaspterpenacid acid I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54815", "l": "(+)-7-isojasmonate + ATP + L-isoleucine <=> AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75849", "l": "SLC25A1 exchanges CIT and MAL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706354", "l": "Ubiquitination of FLT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26213", "l": "9alpha-copalyl diphosphate + H2O = aphidicolan-16beta-ol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.42", "l": "\"aphidicolan-16beta-ol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080123", "l": "jasmonoyl-L-amino acid ligase activity", "d": ["Catalysis of the reaction: a jasmonate + an L-alpha-amino acid + ATP = a jasmonyl-L-amino acid + AMP + diphosphate + H+. In Arabidopsis, isoleucine is the principal amino acid that conjugates with JA to form JA (JA-Ile). Other amino acid can be conjugated with JA such as valine, leucine, and phenylalanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43314", "l": "ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate => ATP + N-(hexanoyl)sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990595", "l": "mast cell secretagogue receptor activity", "d": ["Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48800", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111238", "l": "Formation of ADAR2  homodimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5221061", "l": "TDG excises 5-carboxylcytosine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751040", "l": "PKC phosphorylates G alpha (z) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52500", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36087", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23837", "l": "D-methionine + pyruvate => 4-methylsulfanyl-2-oxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852324", "l": "GTSE1 binds PLK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74830", "l": "UDP-alpha-D-galacturonate(in) + UMP(out) <=> UDP-alpha-D-galacturonate(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77081", "l": "Formation of the CE:GMP intermediate complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58060", "l": "2-sulfinoacetaldehyde + H2O = acetaldehyde + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034544", "l": "trans-ACOHDA hydrolase activity", "d": ["Catalysis of the reaction: trans-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate + H2O = fumarylpyruvate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43477", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 => 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32111", "l": "S-adenosyl-L-methionine + trans-resveratrol = 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685604", "l": "SLAMF6 binds SLAMF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76269", "l": "carnosine(out) => carnosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73366", "l": "beta-alanyl-[peptidyl-carrier protein] + dopamine <=> beta-alanyl-dopamine + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848414", "l": "Activated PTK6 binds CDKN1B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022852", "l": "glycine-gated chloride ion channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25797", "l": "2-oxoglutarate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48916", "l": "a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1c + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708557", "l": "FBXL17 binds BACH1:MAFK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42815", "l": "cholesterol + octadecanoyl-CoA <=> cholesteryl octadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10852", "l": "dimethylallyl diphosphate + leachianone G = diphosphate + sophoraflavanone G", "d": [], "t": []}, {"i": "EC:2.5.1.71", "l": "\"leachianone-G 2''-dimethylallyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222411", "l": "Peroxynitrite oxidizes Peptide-Methionine residues (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110215", "l": "Cleavage of uracil by UNG glycosylase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30391", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamine = 2-oxoglutaramate + L-methionine", "d": [], "t": []}, {"i": "EC:2.6.1.117", "l": "\"L-glutamine--4-(methylsulfanyl)-2-oxobutanoate aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22160", "l": "4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside = a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.173", "l": "\"flavonol-3-O-triglucoside O-coumaroyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67059", "l": "chermesin D + S-adenosyl-L-methionine <=> chermesin D methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357927", "l": "MLKL oligomerizes  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56965", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate => a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72731", "l": "UDP-alpha-D-glucose(in) + UMP(out) = UDP-alpha-D-glucose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52613", "l": "3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75077", "l": "dihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine => dihydro-6-demethylsterigmatocystin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32396", "l": "(1S,2S,4S)-dihydrocarveol + NAD(+) => (1S,4S)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186780", "l": "PI3-kinase binds to the active receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65710", "l": "beta-L-galactose 1-phosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GDP-beta-L-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043803", "l": "hydroxyneurosporene-O-methyltransferase activity", "d": ["Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + spheroidene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55462", "l": "11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-997237", "l": "SH2B proteins bind JAK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609739", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2C (GRIN2C) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75875", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": [], "t": []}, {"i": "EC:2.1.1.389", "l": "\"[methyl-Co(III) quaternary-amine-specific corrinoid protein]--tetrahydrofolate methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33767", "l": "a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54698", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate => 4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3274540", "l": "Defective G6PC does not hydrolyze glucose 6-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25357", "l": "2,6,10,14-tetramethylpentadecanal + formyl-CoA => 2-hydroxyphytanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64906", "l": "GMP + 2 H(+) + 2 phosphate => GTP + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42907", "l": "guanosine(748) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34142", "l": "Delta(9)-tetrahydrocannabinolate + H(+) <=> CO2 + Delta(9)-tetrahydrocannabinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16715", "l": "glutathione + H(+) + succinate => H2O + S-succinylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35100", "l": "fusidate(in) + H(+)(out) => fusidate(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32990", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20998", "l": "(3E)-2-oxohex-3-enedioate + NH4(+) => (2Z,4E)-2-aminomuconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981892", "l": "Active G alpha (z) binds RGS proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74704", "l": "(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + O2 + reduced [NADPH--hemoprotein reductase] => 5-dehydro-6-demethoxyfumagillol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13332", "l": "A + a 3-oxosteroid <=> a 3-oxo-Delta(1)-steroid + AH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687107", "l": "MAPK4,6 translocate to nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37261", "l": "2-oxobutanoate + H(+) + NADH + NH4(+) => (2S)-2-aminobutanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.8", "l": "\"flavin-containing monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351478", "l": "Association of gamma-H2AX with MCPH1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50221", "l": "(S)-demethyl-4-deoxygadusol => (R)-demethyl-4-deoxygadusol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769007", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689630", "l": "BAP1 binds BAP1-interacting complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21879", "l": "(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) <=> (S)-usnate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27622", "l": "geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.89", "l": "\"tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66881", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.39", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12902", "l": "D-arginine + H2O => D-ornithine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186798", "l": "GAP binds to PDGF-beta receptors only (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74837", "l": "UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-galactosamine(out) => UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43351", "l": "cholesteryl (9Z-octadecenoate)(in) <=> cholesteryl (9Z-octadecenoate)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350186", "l": "CUBN binds GC:25(OH)D (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75142", "l": "4-hydroxyprotoasukamycin + H(+) + NADH + O2 <=> asukamycin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014467", "l": "RHOG binds effectors at the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39875", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76770", "l": "emodin + S-adenosyl-L-methionine <=> physcion + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809521", "l": "BPIF binds bacteria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.30.2", "l": "\"Serratia marcescens nuclease\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836270", "l": "TFAP2A binds TFAP2C (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78280", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + somaliensene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52989", "l": "[deoxyhypusine synthase]-L-lysine + dehydrospermidine => [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71743", "l": "2-oxoglutarate(out) + hexanedioate(in) = 2-oxoglutarate(in) + hexanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018477", "l": "benzaldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395992", "l": "p-T,4S-IRF3 is dimerized (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25601", "l": "4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O = 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50712", "l": "chloride + FADH2 + O2 + tetracycline = 7-chlorotetracycline + FAD + H(+) + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.49", "l": "\"tetracycline 7-halogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008809", "l": "carnitine racemase activity", "d": ["Catalysis of the reaction: D-carnitine = L-carnitine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391866", "l": "Phosphorylation of FAK by Src kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60766", "l": "cinerin II + CoA => (1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17124", "l": "carbamoyl phosphate + L-lysine <=> H(+) + L-homocitrulline + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60380", "l": "L-dehydroascorbate(out) = L-dehydroascorbate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212642", "l": "L-Glutamine transport into neurons (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56048", "l": "daidzein + UDP-alpha-D-glucose = daidzein 7-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27516", "l": "phosphate + sphinganine => H2O + sphinganine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176298", "l": "Activation of claspin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.43", "l": "\"lipid A phosphoethanolamine transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11317", "l": "an aliphatic aldoxime => a nitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352268", "l": "Cleavage of Satb1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75994", "l": "a dicarboxylate(in) + N-benzoylglycine(out) <=> a dicarboxylate(out) + N-benzoylglycine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611158", "l": "Fusion of HCMV Envelope with Plasma Membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.554670414377497", "identifiers": [{"i": "GO:0017171", "l": "serine hydrolase activity", "d": ["Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033806", "l": "fluorothreonine transaldolase activity", "d": ["Catalysis of the reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332236", "l": "CBL neddylates TGFBR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191636", "l": "Phosphorylation of Cx43 by c-src (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62412", "l": "(E)-feruloyl-CoA + H2O = acetyl-CoA + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21810", "l": "glycylglycine => 2,5-dioxopiperazine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0047364", "l": "desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + desulfoglucotropeolin = adenosine 3',5'-diphosphate + glucotropeolin + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2545196", "l": "FN1 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002401", "l": "Association of procollagen type XVIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68837", "l": "(2Z,6E)-farnesyl diphosphate => (6R,7S)-himachala-9,11-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42924", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.198", "l": "\"16S rRNA (cytidine(1402)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758486", "l": "Unknown kinase phosphorylates 9b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76224", "l": "3',5'-cyclic AMP(in) => 3',5'-cyclic AMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70788", "l": "H(+)(in) + L-citrulline(in) + L-ornithine(out) => H(+)(out) + L-citrulline(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72621", "l": "Ribosomal scanning  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788346", "l": "Expression of IL13-upregulated plasma membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-976801", "l": "Complement factor I complex formation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434836", "l": "Syk/Lck phosphorylate LAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20886", "l": "3-hydroxypyruvate + H(+) + NADH + NH4(+) => H2O + L-serine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30105", "l": "5-dehydro-D-gluconate + NAD(+) => 2,5-didehydro-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0017040", "l": "N-acylsphingosine amidohydrolase activity", "d": ["Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10597", "l": "ATP + L-tyrosyl-[protein] => ADP + H(+) + O-phospho-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62037", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59918", "l": "(2E)-octenoate + 2 H(+) + NADPH => (2E)-octenal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72650", "l": "1,6-dihydroxyphenazine + NADPH + O2 <=> 1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210426", "l": "Glutamate synaptic vesicle docking and priming (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68576", "l": "ATP + H2O + xanthine(out) = ADP + H(+) + phosphate + xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76500", "l": "N-acetyl-D-glutamate => N-acetyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62031", "l": "H2O + stigmasteryl 3-beta-D-glucoside <=> D-glucose + stigmasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48733", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O => [CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14090", "l": "2-oxoglutarate + glycine => glyoxylate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712195", "l": "ANO2 dimer binds Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647680", "l": "CASP1 cleaves GSDMD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25759", "l": "ent-copalyl diphosphate = diphosphate + ent-isokaurene", "d": [], "t": []}, {"i": "EC:4.2.3.103", "l": "\"ent-isokaurene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5617815", "l": "BBSome binds RAB3IP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30003", "l": "alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9861734", "l": "PDH E1 decarboxylates PYR, transferring acetyl to DLAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483174", "l": "PE is methylated to PC by PEMT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56311", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21721", "l": "formamide => H2O + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47793", "l": "cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25672", "l": "H(+) + loliose + UDP => sucrose + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61597", "l": "[DsbD protein]-dithiol + [thioredoxin]-disulfide => [DsbD protein]-disulfide + [thioredoxin]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197697", "l": "Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36967", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61108", "l": "(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868340", "l": "CDK5:p25 phosphorylates lamin B1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45983", "l": "3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67206", "l": "acetate + tryptamine => H2O + N-acetyltryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160047", "l": "muramyl dipeptide kinase activity", "d": ["Catalysis of the reaction: ATP + muramyl dipeptide = ADP + H+ + 6-O-phospho-muramyl dipeptide."], "t": []}, {"i": "RHEA:75935", "l": "ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine = 6-O-phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047426", "l": "ricinine nitrilase activity", "d": ["Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033201", "l": "alpha-1,4-glucan synthase activity", "d": ["Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51119", "l": "guanosine(6) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50120", "l": "taurine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449829", "l": "IL11 binds IL11RA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56562", "l": "[1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP => [1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173740", "l": "Factor B binds to C3(H2O) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71670", "l": "PKM dephosphorylates PEP to PYR (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22238", "l": "2-deoxy-D-glucose + phosphate => 2-deoxy-D-glucose 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5591052", "l": "PROCR binds Protein C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33748", "l": "a 1-acyl-sn-glycerol + ATP => a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43687", "l": "ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate <=> AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28026", "l": "[thioredoxin]-disulfide + dUDP + H2O = [thioredoxin]-dithiol + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13638", "l": "H(+) + methane + NADH + O2 => H2O + methanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204824", "l": "Interaction of Tie2 and Ang4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37390", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954056", "l": "E2F6 binds TFDP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950778", "l": "p-Y693-STAT4 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56484", "l": "3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] = gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31888", "l": "(S)-2,3-epoxysqualene => tirucalladienol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5220959", "l": "TDG excises 5-formylcytosine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38194", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone <=> 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726848", "l": "SRC phosphorylates RHOU (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848414", "l": "Activated PTK6 binds CDKN1B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395320", "l": "Latent TGF-beta-1 binds integrins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75241", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[protein] => acetyl-CoA + N-terminal L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76559", "l": "1-(ergostan-3beta-yl)-L-aspartate + H2O = ergosterol + H(+) + L-aspartate", "d": [], "t": []}, {"i": "EC:3.1.1.121", "l": "\"ergosteryl-3beta-O-L-aspartate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.9.1.3", "l": "\"phosphohistidine phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71001", "l": "(S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66768", "l": "ATP + coproporphyrin I(in) + H2O = ADP + coproporphyrin I(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52506", "l": "(9R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75524", "l": "acetyl-CoA + S-methyl-L-cysteine => CoA + H(+) + N-acetyl-S-methyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45084", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.130", "l": "\"laurate 7-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27271", "l": "CoA + hexadecanal + NADP(+) => H(+) + hexadecanoyl-CoA + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654409", "l": "Activated FGFR3 binds FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32213", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate => (Z)-5-oxohex-2-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004883", "l": "nuclear glucocorticoid receptor activity", "d": ["Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42293", "l": "a fatty acyl-[ACP] + phosphate => an acyl phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878257", "l": "RUNX2 binds the IHH gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12242", "l": "6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+) => acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051724", "l": "NAD transmembrane transporter activity", "d": ["Enables the transfer of NAD from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57817", "l": "dGMP + H2O => 2-deoxy-D-ribose 5-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10568", "l": "luteolin + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-beta-D-glucuronide + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.189", "l": "\"luteolin 7-O-glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56712", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.145", "l": "\"phosphatidylglycerol--prolipoprotein diacylglyceryl transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68483", "l": "(2R)-2-hydroperoxyhexadecanoate + H(+) <=> CO2 + H2O + pentadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624952", "l": "Assembly of the retrograde IFT train (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25315", "l": "2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = L-2-acetamido-6-oxoheptanedioate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70260", "l": "AMP(out) + phosphate(in) => AMP(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033288", "l": "ATPase-coupled hydroxyectoine transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944246", "l": "Association of procollagen type XXI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67837", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70218", "l": "cortisol + H(+) + NADPH <=> 20beta-dihydrocortisol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30922", "l": "A + rhodopin <=> (3E)-3,4-didehydrorhodopin + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42102", "l": "6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate => ATP + carbamoyl phosphate + H2O + kanamycin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35983", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190265", "l": "FGFR4 binds to FGF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48806", "l": "(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13044", "l": "L-dopachrome <=> 5,6-dihydroxyindole-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209925", "l": "DIT and MIT combine to form triiodothyronine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.39", "l": "\"gluconate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19401", "l": "methanol + NAD(+) = formaldehyde + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.244", "l": "\"methanol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33230", "l": "(E)-4-coumarate + H(+) <=> 4-hydroxystyrene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549304", "l": "OCT3 mediates renal clearance of organic cations (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13722", "l": "H2O + testololactone => H(+) + testolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067667", "l": "IL6 binds IL6R (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.382", "l": "\"ketol-acid reductoisomerase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29704", "l": "L-valine(in) => L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37415", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44762", "l": "6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.2", "l": "\"dihydropyrimidinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22462", "l": "a 2,3-dehydroacyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51098", "l": "19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016515", "l": "interleukin-13 receptor activity", "d": ["Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25753", "l": "H(+) + H2O + N,N-dihydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77438", "l": "a ganglioside GT1c + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GQ1c + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70623", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43059", "l": "5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH <=> 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214864", "l": "Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69381", "l": "2-hydroxy-4-methylpentanoate + O2 => 4-methyl-2-oxopentanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64272", "l": "benzylamine + pyruvate = benzaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39204", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADPH => NADP(+) + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75868", "l": "5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => 5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10199", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate <=> 2-succinylbenzoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1834939", "l": "STING recruits TBK1 and IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23287", "l": "isopentenyl diphosphate <=> dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55491", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44171", "l": "dodecanoate + 2 H(+) + NADH <=> dodecanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.25", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34691", "l": "(R)-lactoyl-CoA = acryloyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.54", "l": "\"lactoyl-CoA dehydratase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78441", "l": "a 1,2-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19835", "l": "(6S)-5,6,7,8-tetrahydrofolate + formate + H(+) => (6R)-10-formyltetrahydrofolate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043472", "l": "IgD binding", "d": ["Binding to an immunoglobulin of a D isotype."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51760", "l": "a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047261", "l": "steroid N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: estradiol-17alpha 3-D-glucuronoside + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside + H+ + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015347", "l": "sodium-independent organic anion transmembrane transporter activity", "d": ["Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40029", "l": "(13S)-vitexifolin A + diphosphate => 9alpha-copalyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13116", "l": "2-acetamidofluorene + H2O + NADP(+) <=> H(+) + N-hydroxy-2-acetamidofluorene + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68058", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797553", "l": "Protein 4.1 binds CASK (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64949", "l": "dCTP + H2O => dCDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38839", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701064", "l": "TRPV1 binds TRPV1 agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877361", "l": "Pyrin binds ASC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70352", "l": "beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O => beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28561", "l": "D-fructose 6-phosphate + H2O <=> D-fructose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203977", "l": "SAR1 Activation And Membrane Binding (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983147", "l": "Release of E3 from polyubiquitinated substrate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68586", "l": "ADP + H(+) + L-tryptophan(in) + phosphate => ATP + H2O + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51048", "l": "5alpha-androstan-3,17-dione + A = AH2 + androst-4-ene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65966", "l": "ADP + H(+) + phosphate + taurocholate(in) => ATP + H2O + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22681", "l": "dCTP + H(+) + H2O => dUTP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68165", "l": "N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71303", "l": "RPE dimers isomerise RU5P to XY5P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018794", "l": "RHOV binds effectors at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653249", "l": "Cleavage of factor XII variant by activated thrombin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12559", "l": "6-phospho-D-glucono-1,5-lactone + H2O <=> 6-phospho-D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78035", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol = a 1,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43542", "l": "ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase] => ATP + L-seryl-[isocitrate dehydrogenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63603", "l": "H2O + neocasomorphin <=> L-isoleucine + neocasomorphin-(1-5)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010396", "l": "SLIT1 binds COL4A5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61907", "l": "betaenone A + H(+) + NADPH + O2 <=> H2O + NADP(+) + stemphyloxin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48071", "l": "a ganglioside GM2 (d18:1(4E)) + H2O <=> a ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25963", "l": "benzoin + NADP(+) <=> benzil + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130619", "l": "TGN-lysosomal vesicle coat assembly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61565", "l": "a tetracycline + H(+) + NADPH + O2 => a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606392", "l": "Lewis antigens translocate from Golgi lumen to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022141", "l": "Prolysyl oxidase activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34745", "l": "13-methyltetradecanal + phosphoethanolamine => 15-methylhexadecasphinganine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034886", "l": "gamma-aminovinylacetate deaminase activity", "d": ["Catalysis of the reaction: gamma-aminovinylacetate + H2O = succinic semialdehyde + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9837978", "l": "LONP1 binds mitochondrial inner membrane proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036081", "l": "extracellular ammonia-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59308", "l": "D-galactono-1,5-lactone + H2O = D-galactonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19109", "l": "1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.143", "l": "\"beta-glucogallin--tetrakisgalloylglucose O-galloyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021609", "l": "ESR-associated SRC autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43071", "l": "beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68611", "l": "Formation of ORC(1-5) complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632766", "l": "TP53 stimulates SCO2 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44402", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-6 => 3-demethylubiquinol-6 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691621", "l": "C5 binds C5 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032854", "l": "NTRK2 phosphorylates CDK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78025", "l": "a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17678", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O => 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674022", "l": "BRAP autoubiquitinates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18948", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68891", "l": "2-methoxybenzoate + ATP + H(+) + NADPH <=> 2-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-421835", "l": "trans-Golgi Network Vesicle Scission (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73244", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether => cirsimaritin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019211", "l": "phosphatase activator activity", "d": ["Binds to and increases the activity of a phosphatase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874685", "l": "CBL binds MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22252", "l": "a globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a globoside Gb4Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.79", "l": "\"globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0033892", "l": "deoxyribonuclease (pyrimidine dimer) activity", "d": ["Catalysis of the endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.60", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19890", "l": "alpha-D-glucose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48759", "l": "erythritol + NAD(+) <=> D-erythrulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42943", "l": "cytidine(34) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58722", "l": "H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide => (S)-nicotine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61107", "l": "(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.98", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018746", "l": "RHOQ binds effectors at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9861642", "l": "NEK1 phosphorylates ME1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-396941", "l": "Thrombin-activated PARs binds G-protein G12/13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45949", "l": "acetyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70979", "l": "MDH2 dimer dehydrogenates MAL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036432", "l": "all-trans undecaprenol kinase activity", "d": ["Catalysis of the reaction: ATP + undecaprenol + all-trans-undecaprenyl phosphate + ADP + H+."], "t": []}, {"i": "RHEA:23752", "l": "all-trans-undecaprenol + ATP = ADP + all-trans-undecaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10197", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate => 2-succinylbenzoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35603", "l": "beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37430", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45516", "l": "phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24415", "l": "4-(hydroxymethyl)benzenesulfonate + NAD(+) <=> 4-formylbenzenesulfonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48175", "l": "a ganglioside GM2 + H2O <=> a ganglioside GA2 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15779", "l": "1-guanidino-1-deoxy-scyllo-inositol + phosphate => 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49287", "l": "8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP <=> CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3215406", "l": "PRMT5 binds WDR77 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57886", "l": "H(+) + Na(+)(out) + 2 phosphate => diphosphate + H2O + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.53", "l": "\"endopeptidase La\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29865", "l": "ADP + GDP => AMP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937034", "l": "IRAK1 phosphorylates Pellino (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79115", "l": "L-arginine + taurocholate = L-arginocholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379464", "l": "COMT transfers Met to DOPAC to form HVA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24184", "l": "4,5-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.55", "l": "\"4,5-dihydroxyphthalate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72597", "l": "H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in) => H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72258", "l": "dopamine + S-adenosyl-L-methionine <=> 3-methoxytyramine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38640", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34559", "l": "1-deoxy-11beta-hydroxypentalenate + NAD(+) = 1-deoxy-11-oxopentalenate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.340", "l": "\"1-deoxy-11beta-hydroxypentalenate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.3", "l": "\"ribonuclease III\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473596", "l": "Collagen type I degradation by MMP15 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047100", "l": "glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity", "d": ["Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71412", "l": "3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in) => 3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48079", "l": "a primary alcohol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140933", "l": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity", "d": ["Catalysis of the reaction: a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + N7-methyl-GDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42758", "l": "5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26182", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61506", "l": "pelargonidin 3-O-beta-D-glucoside + UDP => pelargonidin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102157", "l": "(R)-sulfopropanediol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD = 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389463", "l": "Proteinase-activated receptors can bind thrombin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031927", "l": "pyridoxamine transmembrane transporter activity", "d": ["Enables the transfer of pyridoxamine from one side of a membrane to the other. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23183", "l": "a secondary alcohol + O2 <=> a ketone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26489", "l": "H(+) + O-phospho-L-serine + sulfite <=> L-cysteate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61244", "l": "H2O + L-tryptophan + O2 = H2O2 + indole-3-pyruvate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59488", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56419", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate <=> alpha-D-glucose 1-phosphate + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13040", "l": "ATP + H(+) + H2O <=> ITP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678998", "l": "Endosomal TLRs pass through the Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25595", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2 => 2-oxoglutarate + H(+) + isochorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31166", "l": "(3S)-hydroxyhexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51767", "l": "dimethylallyl diphosphate + phlorisovalerophenone <=> 4-prenylphlorisovalerophenone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175993", "l": "HNMT transfers CH3 group from AdoMet to Hist (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654573", "l": "Activated FGFR1 binds SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20366", "l": "phosphoethanolamine + S-adenosyl-L-methionine => H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944454", "l": "mTORC1 phosphorylates MAF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249378", "l": "STING recruits TBK1 and STAT6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24465", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate => D-glyceraldehyde 3-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10286", "l": "(3R)-beta-leucine => L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56062", "l": "CO2 + pentadecane => H(+) + hexadecanoate + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905057", "l": "voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels", "d": ["Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102830", "l": "verbascose synthase activity", "d": ["Catalysis of the reaction: 2 stachyose = verbascose + raffinose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63481", "l": "NADP(+) + prostaglandin F2alpha => 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33559", "l": "an acyl-CoA + sn-glycerol 3-phosphate = a 2-acyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.198", "l": "\"glycerol-3-phosphate 2-O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693929", "l": "RIPK1 variant is not cleaved by CASP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76702", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione <=> (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656248", "l": "Defective SLC4A1 does not exchange Cl- for HCO3- (in erythrocytes) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2172666", "l": "RB1 binds condensin II (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42005", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14299", "l": "an N-acylsphing-4-enine + D-galactose => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42025", "l": "3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) => 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43697", "l": "H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate => diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013004", "l": "RHOA binds effectors at the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018465", "l": "vanillyl-alcohol oxidase activity", "d": ["Catalysis of the reaction: O2 + vanillyl alcohol = H2O2 + vanillin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1008200", "l": "NFE2 binds the beta globin locus control region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59248", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA = (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50082", "l": "ADP + H(+) + phosphate + taurodeoxycholate(out) => ATP + H2O + taurodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40678", "l": "L-threonine <=> 2-aminobut-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015667", "l": "site-specific DNA-methyltransferase (cytosine-N4-specific) activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5615668", "l": "AKR1C3 reduces atRAL to atROL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021050", "l": "HSBP1 oligomer binds ESRs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17016", "l": "H(+) + phosphoenolpyruvate <=> 3-phosphonopyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008851", "l": "ethanolamine ammonia-lyase activity", "d": ["Catalysis of the reaction: ethanolamine = acetaldehyde + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39138", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57806", "l": "4-chlorocatechol + NAD(+) + nitrite => 1-chloro-3-nitrobenzene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514865", "l": "cGMP dissociates from CNG channels (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.54", "l": "\"UDP-2,3-diacylglucosamine diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31120", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA => (2E)-2-methylbut-2-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203070", "l": "Association of profilin with monomeric actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9653514", "l": "USP17L2 deubiquitinates RCE1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54878", "l": "(3S)-3-isopropenyl-6-oxoheptanoate + H(+) => (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71173", "l": "GSTZ1 isomerizes 4-MAA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54090", "l": "2,4,5-trihydroxyphenylacetate + H2O + NAD(+) => 3,4-dihydroxyphenylacetate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001095", "l": "TFIIE-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43593", "l": "all-trans-zeaxanthin + O2 => (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.17", "l": "\"non-specific polyamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28197", "l": "(2S)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48674", "l": "20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65678", "l": "a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25783", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine <=> 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58985", "l": "acrolein + H2O + O2 => acrylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49082", "l": "dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O => dibenzothiophene 5-oxide + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102438", "l": "laricitrin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: laricitrin(1-) + S-adenosyl-L-methionine = H+ + 3',4'-dimethylmyricetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75630", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O <=> ectocarpin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69961", "l": "6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53432", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53802", "l": "lithocholate + ursodeoxycholoyl-CoA => lithocholoyl-CoA + ursodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34885", "l": "ADP + H(+) + phosphate + selenate(in) => ATP + H2O + selenate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51849", "l": "8-methylmenaquinone-6 + succinate => 8-methylmenaquinol-6 + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809309", "l": "MTMR6 binds MTMR9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647978", "l": "pro-RAS proteins are farnesylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44922", "l": "(3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+) => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9650473", "l": "SERPING1 is secreted (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53379", "l": "5,6-dihydrouridine(16) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(16) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43170", "l": "inosine(34) in tRNA + NH4(+) => adenosine(34) in tRNA + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34431", "l": "(+)-secoisolariciresinol + NADP(+) = (-)-lariciresinol + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.23.1.4", "l": "\"(-)-lariciresinol reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24109", "l": "H2O + N-methyl-2-oxoglutaramate => 2-oxoglutarate + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016149", "l": "translation release factor activity, codon specific", "d": ["A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35314", "l": "3-hydroxyisoheptadecanoyl-CoA + NADP(+) <=> 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045131", "l": "pre-mRNA branch point binding", "d": ["Binding to a pre-mRNA branch point sequence, located upstream of the 3' splice site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39584", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35487", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.51", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68062", "l": "a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29518", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983142", "l": "Formation of peptide loading complex (PLC) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20889", "l": "3-hydroxy-2-methylpropanoyl-CoA + H2O => 3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210271", "l": "Interaction of DAP12 and MDL-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322434", "l": "XIAP dissociates from ub-TLE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42243", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052579", "l": "(+)-pulegone reductase, (+)-isomenthone as substrate, activity", "d": ["Catalysis of the reaction: (+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70979", "l": "MDH2 dimer dehydrogenates MAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445700", "l": "Myosin Binds ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77650", "l": "(2E,10E)-dode-2,10-dicenoyl-CoA + H(+) + oxaloacetate <=> [4-(deca-1,8-diyl)-2,5-dioxo-2,5-dihydro-3-furanyl]acetate + CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32486", "l": "H(+) + H2O + pheophorbide a <=> CO2 + methanol + pyropheophorbide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64067", "l": "(1R,2R)-pseudoephedrine + NAD(+) <=> (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59390", "l": "a fatty acid + an aliphatic alcohol + H(+) => a fatty acid ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55435", "l": "11-hydroxyferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> carnosate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734475", "l": "PPARA binds fibrates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114683", "l": "Phosphorylation of Platelet Sec-1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38195", "l": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162193", "l": "COQ3 methylates DHDB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5672011", "l": "p-AMPK:AMP binds the ULK complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37352", "l": "cytidine 2'-phosphate + H2O => cytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73806", "l": "AIR + CO2 => CAIR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57785", "l": "1,4-dinitrobenzene + NADH + O2 => 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57935", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64578", "l": "2 Fe(II)-[cytochrome b5] + H(+) + NADP(+) => 2 Fe(III)-[cytochrome b5] + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170706", "l": "Phosphorylation of  NEFL by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43548", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72335", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate = 3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14266", "l": "(S)-4-amino-5-oxopentanoate => 5-aminolevulinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39694", "l": "(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH <=> (11Z)-octadecenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26485", "l": "adenosine(37) in tRNA + dimethylallyl diphosphate <=> diphosphate + N(6)-dimethylallyladenosine(37) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15239", "l": "2 Fe(II)-[cytochrome c2] + H(+) + NADP(+) => 2 Fe(III)-[cytochrome c2] + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64327", "l": "(11Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (11Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106166", "l": "spindle pole body-nuclear membrane anchor activity", "d": ["The binding activity of a molecule that brings together a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019180", "l": "dTDP-4-amino-4,6-dideoxygalactose transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78976", "l": "(R)-5-phosphomevalonate => (2E)-3-methyl-5-phosphooxypent-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66672", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) = 5,7-dihydroxy-4-methylphthalide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000327", "l": "PLK1 phosphorylates BORA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865182", "l": "OTUD7A hydrolyses K11diUb (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141423", "l": "Binding of the MCC complex to the APC/C complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30297", "l": "GDP + H(+) + phosphoenolpyruvate => GTP + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694421", "l": "PP6 dephosphorylates SEC24 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59217", "l": "(indol-3-yl)acetate + H(+) => CO2 + skatole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655733", "l": "Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424476", "l": "Activation of RAC1 by VAV2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0050486", "l": "intramolecular hydroxytransferase activity", "d": ["Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule."], "t": []}, {"i": "EC:5.4.4.-", "l": "\"Transferring hydroxy groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59037", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75821", "l": "(5S)-hydroperoxy-(6E,8Z)-octadecadienoate => (5Z,8Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.16", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183051", "l": "CBL ubiquitinates Sprouty (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76258", "l": "a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA <=> (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22967", "l": "H(+) + L-ornithine <=> CO2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209766", "l": "25(OH)D translocates from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.88", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24407", "l": "(3S)-hydroxy-3-methylglutaryl-CoA <=> acetoacetate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57407", "l": "NAD(+) + narcotine hemiacetal <=> H(+) + NADH + noscapine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38737", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828723", "l": "M2 mRNA is translated into protein M2-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77779", "l": "2-oxoglutarate + 6-sulfo-D-quinovose + O2 = 6-dehydro-D-glucose + CO2 + H(+) + succinate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50403", "l": "L-cysteinyl-[PqsC protein] + octanoyl-CoA <=> CoA + S-octanoyl-L-cysteinyl-[PqsC protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70573", "l": "argininosuccinate <=> fumarate + arginine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004768", "l": "stearoyl-CoA 9-desaturase activity", "d": ["Catalysis of the reaction: 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11193", "l": "an (S)-2-haloacid + H2O => a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31630", "l": "10-deoxymethynolide + dTDP-alpha-D-desosamine <=> 10-deoxymethymycin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40120", "l": "H2O + tetradecanoyl-CoA => CoA + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675417", "l": "PEBP1 binds activated RAF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944262", "l": "Association of procollagen type X (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18530", "l": "3-methylbutanol + NAD(+) => 3-methylbutanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71344", "l": "chloride(out) + L-histidine(out) + 2 Na(+)(out) => chloride(in) + L-histidine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45691", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) <=> N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75317", "l": "chloride(in) + D-serine(in) + 2 Na(+)(in) => chloride(out) + D-serine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38228", "l": "(9Z)-octadecenoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl (9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088134", "l": "PLK1 phosphorylates FOXM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050484", "l": "GMP 5'-nucleotidase activity", "d": ["Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13705", "l": "alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine = alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.138", "l": "\"mannotetraose 2-alpha-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36853", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA => (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70923", "l": "(R)-noradrenaline(out) + chloride(out) + Na(+)(out) = (R)-noradrenaline(in) + chloride(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78312", "l": "dAMP + dATP => 2 dADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.352372097681226", "identifiers": [{"i": "GO:0019239", "l": "deaminase activity", "d": ["Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69530", "l": "4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+) => chorismate + H2O + 2 L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0140829", "l": "bicarbonate:monoatomic anion antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(in) + HCO3-(out) = solute(out) + HCO3-(in)."], "t": []}, {"i": "TCDB:2.A.31.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57841", "l": "1D-myo-inositol 1,3-bisphosphate + H2O => 1D-myo-inositol 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32343", "l": "(+)-thujan-3-ol + NAD(+) = (+)-thujan-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14863", "l": "H(+) + NADPH + orotate => (S)-dihydroorotate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34416", "l": "(1R,4R)-bornane-2,5-dione + FMNH2 + O2 => (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730841", "l": "Phosphorylation and activation of VAV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390930", "l": "5-HT2 receptor can bind serotonin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53550", "l": "Delta(12)-prostaglandin J2 => prostaglandin J2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18277", "l": "a thiol + S-adenosyl-L-methionine = a methyl thioether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.9", "l": "\"thiol S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705465", "l": "p-Y-STAT1,3,5 dimer binds SOCS3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33670", "l": "H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 <=> H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37796", "l": "2 H(+) + 2 NADPH + O2 => 2 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299478", "l": "MPP cleaves targeting peptide (presequence) of matrix precursors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097023", "l": "fructose 6-phosphate aldolase activity", "d": ["Catalysis of the reaction: D-fructose-6-phosphate = dihydroxyacetone + D-glyceraldehyde-3-phosphate."], "t": []}, {"i": "RHEA:28002", "l": "beta-D-fructose 6-phosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53765", "l": "allocholate + lithocholoyl-CoA => allocholoyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74454", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46614", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61140", "l": "(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + myricetin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806629", "l": "Formation of tonofilament bundles (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730505", "l": "SARS-CoV-2 3a binds to UVRAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018675", "l": "(S)-limonene 6-monooxygenase activity", "d": ["Catalysis of the reaction: (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28261", "l": "cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate <=> cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73726", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate <=> (2R,3S,11S)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399942", "l": "Plexin-A1-4 binds NRP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050342", "l": "tocopherol C-methyltransferase activity", "d": ["Catalysis of the reaction: gamma-tocopherol + S-adenosyl-L-methionine = (+)-alpha-tocopherol + H+ + S-adenosyl-L-homocysteine. This reaction can also use delta-tocopherol, gamma-tocotrienol and delta-tocotrienol as substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674095", "l": "PDGFRs bind type II TKI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2995330", "l": "COX10 transforms heme to heme O (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48454", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine => a ganglioside GA2 (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41451", "l": "2-oxoglutarate + L-isoleucine + O2 <=> (4S)-4-hydroxy-L-isoleucine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13699", "l": "ADP + D-ribose 5-phosphate + H(+) => ATP + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390641", "l": "ADRA1A,B,D bind ADR,NAd (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102301", "l": "gamma-linolenate elongase activity", "d": ["Catalysis of the reaction: malonyl-CoA + gamma-linolenoyl-CoA + H+ = (8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl-CoA + coenzyme A + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420724", "l": "CASR binds Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30940", "l": "ATP + dIDP => ADP + dITP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54544", "l": "1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine = 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71428", "l": "3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) => 3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003959", "l": "NADPH dehydrogenase activity", "d": ["Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34061", "l": "didehydroagroclavine + H(+) + NADPH => agroclavine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033978", "l": "phosphonopyruvate hydrolase activity", "d": ["Catalysis of the reaction: 3-phosphonopyruvate + H2O = H+ + phosphate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74885", "l": "GUCYs converts GTP to cGMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23564", "l": "2 columbamine + O2 = 2 berberine + 2 H2O", "d": [], "t": []}, {"i": "EC:1.21.3.2", "l": "\"columbamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46392", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14801", "l": "(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP", "d": [], "t": []}, {"i": "EC:2.7.2.3", "l": "\"phosphoglycerate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205244", "l": "Recruitment of CBL to KIT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13994", "l": "(S)-3-amino-2-methylpropanoate + 2-oxoglutarate => 2-methyl-3-oxopropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204773", "l": "Interaction of Tie2 and Grb7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497878", "l": "Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9825747", "l": "CREBBP acetylates HINT1 dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691154", "l": "HFE binds TFRC dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047741", "l": "cetraxate benzylesterase activity", "d": ["Catalysis of the reaction: benzyl cetraxate + H2O = benzyl alcohol + cetraxate + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33047", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] = (+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.10", "l": "\"(+)-camphor 6-endo-hydroxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30942", "l": "ATP + dIDP <=> ADP + dITP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73335", "l": "ATP + beta-alanine + tryptamine = AMP + beta-alanyl-tryptamine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928656", "l": "gamma-secretase cleaves EPHB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32326", "l": "ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018794", "l": "RHOV binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61218", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042163", "l": "interleukin-12 beta subunit binding", "d": ["Binding to the beta subunit of interleukin-12."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44485", "l": "3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57074", "l": "CO2 + L-erythrulose 1-phosphate => 3-oxoisoapionate 4-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52725", "l": "3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate => a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682465", "l": "RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030778", "l": "columbamine O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H+ + palmatine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44923", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH <=> (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60248", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42703", "l": "6-carboxyhexanoyl-[ACP] methyl ester + H2O <=> 6-carboxyhexanoyl-[ACP] + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141367", "l": "Myristoylation of tBID by NMT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34367", "l": "acrylamide + H2O = acrylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42789", "l": "cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050522", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP."], "t": []}, {"i": "EC:1.20.98.-", "l": "\"With other, known acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50362", "l": "benzoyl cyanide + H2O2 => (R)-mandelonitrile + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9866253", "l": "apo-UQCRFS1 binds LYRM7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28379", "l": "ATP + N(6)-(D-fructosyl)-L-lysine => ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14969", "l": "S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.144", "l": "\"trans-aconitate 2-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13545", "l": "(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] = (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.58", "l": "\"trimethyltridecatetraene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71204", "l": "L-homoarginine(in) => L-homoarginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47564", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GA2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73042", "l": "H(+)(out) + Ni(2+)(out) <=> H(+)(in) + Ni(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16863", "l": "(7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate => (8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264848", "l": "apoA-I binds to CUBN:AMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70801", "l": "L-lysine(out) + L-ornithine(in) => L-lysine(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.58", "l": "\"glucan 1,3-beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429101", "l": "HMIT co-transports myo-inositol with a proton (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72796", "l": "bilirubin IXalpha bis-beta-D-glucuronoside(out) => bilirubin IXalpha bis-beta-D-glucuronoside(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70636", "l": "H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-392749", "l": "Transport of L1 into endosomes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37096", "l": "(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23067", "l": "an alkanesulfonate + FMNH2 + O2 <=> an aldehyde + FMN + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16816", "l": "H2O + L-kynurenine <=> anthranilate + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141439", "l": "Release of activated MAD2 from kinetochores (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17005", "l": "ATP + D-glucuronate = 1-phospho-alpha-D-glucuronate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.43", "l": "\"glucuronokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64905", "l": "GTP + 2 H2O => GMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24513", "l": "L-serine + pyrazole => 3-(pyrazol-1-yl)-L-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18448", "l": "H2O + IMP <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102498", "l": "maltose glucosidase activity", "d": ["Catalysis of the reaction: H2O + maltose = 2 glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61814", "l": "dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015652", "l": "quaternary ammonium group:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23450", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate => 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694790", "l": "E protein gets N-glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75533", "l": "A + H2O + N-acetyl-L-cysteine => AH2 + N-acetyl-S-hydroxy-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628758", "l": "NEIL1 G83D does not cleave FapyG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22007", "l": "ATP + L-seryl-[myosin light chain] <=> ADP + H(+) + O-phospho-L-seryl-[myosin light chain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53967", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin <=> gamma-L-glutamyl-butirosin B + H(+) + holo-[BtrI ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25264", "l": "2-hydroxyglutarate + FAD + H(+) <=> 2-oxoglutarate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74932", "l": "2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2 => a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70538", "l": "GDP-beta-L-fucose + L-seryl-[EGF-like domain protein] <=> 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31317", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+) => (2R)-3-phosphoglycerate + GDP-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14433", "l": "a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.72", "l": "\"CCA tRNA nucleotidyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693111", "l": "RHOF auto-activates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663752", "l": "KCNN2 transports K+ from the cytosol to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450971", "l": "NNT dimer transfers proton from NADPH to NAD+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018572", "l": "EGFR phosphorylates NOTCH3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25391", "l": "(3Z)-6-oxohex-3-enoyl-CoA + H2O + NADP(+) = cis-3,4-dehydroadipyl-CoA + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.77", "l": "\"3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674529", "l": "AAMP binds to TBXA2R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20205", "l": "methylazoxymethanol + UDP-alpha-D-glucose = cycasin + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.171", "l": "\"methyl-ONN-azoxymethanol beta-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46029", "l": "H2O2 + tetradecanoate => (2R)-hydroxytetradecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682598", "l": "ATM phosphorylates HERC2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694583", "l": "ABHD4 hydrolyses NAPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78911", "l": "a very-long-chain (3S)-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674022", "l": "BRAP autoubiquitinates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43486", "l": "1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045462", "l": "trichothecene 3-O-acetyltransferase activity", "d": ["Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610720", "l": "PKA phosphorylates GLI3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196773", "l": "COASY phosphorylates DP-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0046906", "l": "tetrapyrrole binding", "d": ["Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76672", "l": "furfural + H2O + NADP(+) => 2-furoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58556", "l": "15alpha-stemmadenine intermediate II + H2O = (16S)-deshydroxymethyl-stemmadenine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28468", "l": "pyridoxamine(out) => pyridoxamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10554", "l": "2-dehydro-D-glucose + H2O2 => D-glucose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755303", "l": "26S proteasome degrades HIFalpha (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44842", "l": "CoA + O-octadecanoyl-(R)-carnitine => (R)-carnitine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27874", "l": "isochorismate = pyruvate + salicylate", "d": [], "t": []}, {"i": "EC:4.2.99.21", "l": "\"isochorismate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5622129", "l": "FABP5 binds atRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48638", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53055", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate <=> 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56464", "l": "1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019964", "l": "type II interferon binding", "d": ["Binding to type II interferon, also known as interferon-gamma."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17937", "l": "dihydroxyacetone phosphate = methylglyoxal + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.3", "l": "\"methylglyoxal synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.87", "l": "\"2-hydroxyisoflavanone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14195", "l": "2,3-dihydroxybenzoate + A + H2O => 3-hydroxybenzoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69540", "l": "GTP + streptomycin = 6-O-guanylylstreptomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428127", "l": "SPTLC complexes transfer acyl-CoA onto serine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50564", "l": "acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37186", "l": "(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate <=> 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70967", "l": "IDH3 complex decarboxylates isocitrate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617182", "l": "PRKACA phosphorylates PLN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62658", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate => 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33751", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.27", "l": "\"phosphatidylglycerophosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879762", "l": "Expression of DBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61950", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53959", "l": "gamma-L-glutamyl-[BtrI ACP] + H(+) <=> 4-aminobutanoyl-[BtrI ACP] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77124", "l": "1D-myo-inositol 1,2,3,6-tetrakisphosphate + H2O => 1D-myo-inositol 1,2,3-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0046623", "l": "sphingolipid floppase activity", "d": ["Catalysis of the movement of a sphingolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.67", "l": "\"cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60401", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213239", "l": "Formation of MHC II alpha beta heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23399", "l": "H2O + phloretin <=> 1,3,5-trihydroxybenzene + H(+) + phloretate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55101", "l": "3-oxopentanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxypentanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9835009", "l": "PRKN binds p-S-Ub:MOM proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138432", "l": "DVL2 is phosphorylated by PKC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40078", "l": "6-amino-6-deoxyfutalosine + H(+) + H2O <=> futalosine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070251", "l": "pristanate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018768", "l": "RHOU auto-activates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30285", "l": "(1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+) => (-)-trans-permethrin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433711", "l": "Cis-homodimerization of nectins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.25", "l": "\"glycyl endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.14", "l": "\"bile-salt sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17742", "l": "NAD(+) + shikimate => 3-dehydroshikimate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676257", "l": "Formation of the SET1A complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61829", "l": "stigmasterol + UDP-alpha-D-glucose => H(+) + stigmasteryl 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002935", "l": "tRNA (adenine(37)-C2)-methyltransferase activity", "d": ["Catalysis of the reaction: adenosine37 in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine37 in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990272", "l": "anti-Mullerian hormone receptor activity", "d": ["Combining with anti-Mullerian hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34781", "l": "a 3-oxosteroid + H(+) + NADH => a 3alpha-hydroxysteroid + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674385", "l": "p-T,Y MAPKs dimerize (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380949", "l": "AMPK is dephosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25968", "l": "(S)-benzoin + NADP(+) = benzil + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78524", "l": "2-deoxy-2,3-dehydro-N-acetylneuraminate + H2O => N-acetyl-alpha-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129357", "l": "Fibrillin C-terminal processing (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373148", "l": "succinate + CoASH + GTP <=> succinylCoA + GDP + Pi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21935", "l": "S-adenosyl-L-methionine <=> L-homoserine lactone + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11424", "l": "ATP + L-threonyl-[myosin heavy-chain] = ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]", "d": [], "t": []}, {"i": "EC:2.7.11.7", "l": "\"[myosin heavy-chain] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051730", "l": "GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16010", "l": "ATP + formate => ADP + formyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11262", "l": "H2O2 + NADP(+) => H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41367", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.45", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29809", "l": "ADP + H(+) + L-leucine(in) + phosphate => ATP + H2O + L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622579", "l": "FOXO1,FOXO3,(FOXO4) bind BCL2L11 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64853", "l": "benzoyl-CoA + octan-1-ol => CoA + octyl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19650", "l": "ATP + L-aspartate + tRNA(Asp) => AMP + diphosphate + L-aspartyl-tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "54.520550770365006", "identifiers": [{"i": "GO:0022843", "l": "voltage-gated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71061", "l": "L-arginine(out) + L-leucine(in) => L-arginine(in) + L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39162", "l": "(3R)-hydroxyhexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18384", "l": "dihydroxyacetone + phosphoenolpyruvate <=> dihydroxyacetone phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77032", "l": "(2R)-heptan-2-amine + H2O + NAD(+) => H(+) + heptan-2-one + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76472", "l": "AH2 + cob(III)alamin => A + cob(I)alamin + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849463", "l": "PTK6 phosphorylates SFPQ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28424", "l": "2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452515", "l": "Expression of STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25028", "l": "H(+) + H2O + S-methyl-5'-thioadenosine <=> NH4(+) + S-methyl-5'-thioinosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662466", "l": "XYLB phosphorylates D-xylulose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9845222", "l": "Lumicitabine binds RdRP on nucleocapsid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24445", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40081", "l": "22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => docosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35804", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O => 7,8-dihydroneopterin 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13324", "l": "(R)-3,3-dimethylmalate + NAD(+) <=> 3-methyl-2-oxobutanoate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22841", "l": "D-glutamine + H2O => D-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27296", "l": "6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n) => D-glucose 6-phosphate + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20494", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine => an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047305", "l": "(R)-3-amino-2-methylpropionate-pyruvate transaminase activity", "d": ["Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43686", "l": "AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036397", "l": "formate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: formate + a quinone = CO2 + a quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49111", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine <=> 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39037", "l": "an omega-oxo fatty acid + H(+) + NADH => an omega-hydroxy fatty acid + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033789", "l": "phenylacetyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2 1,4-benzoquinone + H2O + phenylacetyl-CoA = 2 hydroquinone + phenylglyoxylyl-CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047332", "l": "diphosphate-serine phosphotransferase activity", "d": ["Catalysis of the reaction: L-serine + diphosphate = O-phospho-L-serine + H+ + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78399", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = astellifadiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13602", "l": "cis-4-hydroxy-L-proline + NAD(+) => 4-oxo-L-proline + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66413", "l": "ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) => ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379387", "l": "COMT transfers Met to DA to form 3MT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42992", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (R)-nephthenol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.149", "l": "\"nephthenol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839390", "l": "TGFBR3 complex binds to TGFBR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174444", "l": "Formation of C-strand Okazaki fragments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948066", "l": "K63polyUb-IRAK1 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198599", "l": "AKT phosphorylates MDM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3928620", "l": "PAK1 autophosphorylates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-481007", "l": "Exocytosis of platelet alpha granule contents (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75922", "l": "H2O + NADP(+) + serinol <=> dihydroxyacetone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57380", "l": "(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.163", "l": "\"(S)-1-hydroxy-N-methylcanadine 13-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419253", "l": "5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38253", "l": "CoA + hexadecanyl octadecanoate => hexadecan-1-ol + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047959", "l": "glycine dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21969", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate => 3-dehydroquinate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015386", "l": "potassium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55279", "l": "9-cis-retinol + tetradecanoyl-CoA <=> 9-cis-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38044", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189406", "l": "4 PBGs bind to form HMB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44065", "l": "hexadecanoyl-CoA + octan-1-ol => CoA + octyl hexadecanoyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448480", "l": "IL22 binds IL22RA1:JAK1 receptor complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52280", "l": "(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070523", "l": "11-beta-hydroxysteroid dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20808", "l": "acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-7-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26045", "l": "CoA + N-acetyl-9-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199014", "l": "CD96 binds PVR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30741", "l": "myo-inositol + phosphate => 1D-myo-inositol 3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43489", "l": "7(1)-hydroxychlorophyll a + NAD(+) => chlorophyll b + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610735", "l": "NUMB binds ITCH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462014", "l": "Alpha-defensins form biologically active dimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12949", "l": "D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.67", "l": "\"D-fuconate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28558", "l": "D-fructose 6-phosphate + H2O = D-fructose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008458", "l": "carnitine O-octanoyltransferase activity", "d": ["Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64772", "l": "S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine = 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000248", "l": "C-5 sterol desaturase activity", "d": ["Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19943", "l": "coclaurine + H(+) + S-adenosyl-L-homocysteine => norcoclaurine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749920", "l": "HEY1,HEY2 bind GATA4,GATA6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678843", "l": "ISGylation of protein translation regulator 4EHP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51513", "l": "H2O + oxamate => NH4(+) + oxalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9858321", "l": "DHTKD1 dimer decarboxylates 2-OA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047512", "l": "(S,S)-butanediol dehydrogenase activity", "d": ["Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD+ = acetoin + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75831", "l": "5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] = 5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39335", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22589", "l": "4-aminobutanal => 1-pyrroline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47111", "l": "cholate + taurine <=> H2O + taurocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27462", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) => diphosphate + GDP-D-glycero-alpha-D-manno-heptose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130504", "l": "Cleavage of lip22 to lip10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0036440", "l": "citrate synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29129", "l": "a menaquinone + H2O + nitrite => a menaquinol + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645137", "l": "Activator phosphorylates STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67200", "l": "H2O + N-acetyltyramine = acetate + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62598", "l": "(6E)-8-oxogeranial + H(+) + NADH => (S)-8-oxocitronellyl enol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010284", "l": "lariciresinol reductase activity", "d": ["Catalysis of the reaction: lariciresinol + NADPH + H+ = secoisolariciresinol + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41924", "l": "(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52924", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030559", "l": "rRNA pseudouridylation guide activity", "d": ["Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734540", "l": "ACLY tetramer binds ETC-1002-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46412", "l": "a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201611", "l": "Caspase-mediated cleavage of Rock-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37920", "l": "(9Z,12Z)-octadecadienoate + O2 => (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74307", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + NAD(+) = 12alpha-hydroxy-3-oxochola-4-en-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399988", "l": "AKT1 E17K mutant phosphorylates NR4A1 (NUR77) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39159", "l": "(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943083", "l": "US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218805", "l": "PKC autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47273", "l": "monoanhydrobacterioruberin => bisanhydrobacterioruberin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18273", "l": "H2O + O2 + putrescine = 4-aminobutanal + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.3.10", "l": "\"putrescine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373724", "l": "Nephrin binds NCK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76058", "l": "norreticuline + S-adenosyl-L-methionine <=> H(+) + reticuline + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28646", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-zingiberene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49503", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57197", "l": "H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] => glycolate + H(+) + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14527", "l": "AH2 + alpha-cyclopiazonate => A + beta-cyclopiazonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420131", "l": "The PACAP receptor binds PACAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9609310", "l": "β-blockers bind ADRB1,2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61585", "l": "cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008684", "l": "TBK1 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17572", "l": "(R)-reticuline + NADP(+) <=> 1,2-dehydroreticuline + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862280", "l": "FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74919", "l": "a (2E)-2-fatty-enoyl-AMP + holo-[ACP] = a (2E)-enoyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25175", "l": "L-citrulline + methylamine => H2O + N(omega)-methyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75113", "l": "4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 32-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62899", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851068", "l": "Crizotinib-driven IL10RA gene expression in NPM1-ALK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.n2", "l": "\"blood group B linear chain alpha-1,3-galactosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977301", "l": "Histidine is decarboxylated to histamine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57437", "l": "guaethol + O2 + reduced [NADH--hemoprotein reductase] => acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21026", "l": "H(+) + NADPH + oxalyl-CoA => CoA + glyoxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74721", "l": "7-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine => myricetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13078", "l": "a D-hexose + an acyl phosphate => a carboxylate + D-hexose phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68613", "l": "H(+) + NADPH + prostaglandin E1 => NADP(+) + prostaglandin F1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12372", "l": "2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O = 4-oxohex-2-enedioate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.45", "l": "\"carboxymethylenebutenolidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39193", "l": "docosanoyl-CoA + NADP(+) => (2E)-docosenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11251", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67617", "l": "8-oxo-GTP + H2O => 8-oxo-GMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696605", "l": "USP12, USP26 deubiquitinate AR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65899", "l": "glyoxylate + L-kynurenine <=> glycine + H2O + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72185", "l": "mRNA polyadenylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42168", "l": "20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391935", "l": "DP1 receptor can bind PGD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68880", "l": "ATP + H(+) + NADPH + salicylate = AMP + diphosphate + NADP(+) + salicylaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38936", "l": "cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54642", "l": "(12E)-labda-8(17),12,14-triene + diphosphate => (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63935", "l": "abscisate(in) + ATP + H2O <=> abscisate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48139", "l": "a ganglioside GM3 + H2O <=> a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61891", "l": "diosgenin + UDP-alpha-D-glucose <=> diosgenin 3-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29775", "l": "alpha-D-ribose 1-phosphate + ATP = ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.239", "l": "\"alpha-D-ribose-1-phosphate 5-kinase (ATP)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37433", "l": "2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine => 12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78111", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine = a 2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658438", "l": "SPRED dimer binds NF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23238", "l": "H(+) + L-glutamyl-[protein] + methanol => [protein]-L-glutamate 5-O-methyl ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102174", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372741", "l": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53927", "l": "a secondary amine + S-adenosyl-L-methionine <=> a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433506", "l": "Phosphorylation of APS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033192", "l": "calmodulin-dependent protein phosphatase activity", "d": ["Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36733", "l": "1-nitrocyclohexene + H(+) + NADPH => 1-nitrocyclohexan + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61048", "l": "lochnericine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64752", "l": "3-sulfanylpentan-1-ol-L-cysteine + H2O = 3-sulfanyl-1-pentanol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428750", "l": "Gq activation by TP receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641206", "l": "RSPOs bind LGRs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21162", "l": "ATP + citrate + CoA => acetyl-CoA + ADP + oxaloacetate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6793666", "l": "MDM2 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047448", "l": "5-dehydro-4-deoxyglucarate dehydratase activity", "d": ["Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucarate + H+ = 2,5-dioxopentanoate + CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62099", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70074", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sitosterol <=> (22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33308", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] => (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40562", "l": "dTDP-beta-L-evernosamine + NADPH + O2 <=> dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75211", "l": "Cu(+)(out) = Cu(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54998", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677050", "l": "Formation of the GCN5-ATAC complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106415", "l": "muramoyltetrapeptide carboxypeptidase activity", "d": ["GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H2O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59417", "l": "H2O + O2 + tryptamine => H2O2 + indole-3-acetaldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14518", "l": "(E)-feruloyl-CoA + H2O => 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32536", "l": "(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O => 4-hydroxy-2-oxohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112271", "l": "The receptor:G-protein complex dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18389", "l": "alpha-D-xylose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-xylose", "d": [], "t": []}, {"i": "EC:2.7.7.11", "l": "\"UTP--xylose-1-phosphate uridylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18688", "l": "H(+) + NADPH + O2 + pentachlorophenol <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73126", "l": "isorhamnetin + S-adenosyl-L-methionine <=> H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9724685", "l": "IgE binds omalizumab (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68615", "l": "Formation of ORC(1-6) complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59492", "l": "(2E)-geranyl diphosphate + L-tryptophyl-[protein] = (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14359", "l": "ADP + FMN + H(+) => ATP + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70600", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18819", "l": "acetate + malonyl-CoA => acetyl-CoA + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917841", "l": "Acidification of Tf:TfR1 containing endosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5213466", "l": "RIPK3 is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839078", "l": "Cytosolic FGFR1 fusion proteins bind PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428696", "l": "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63857", "l": "O2 + tetradecanoate => (2R)-2-hydroperoxytetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203774", "l": "Interaction of Csk with PAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381500", "l": "Cathepsin G proteolyzes IGF:IGFBP3:ALS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1370505", "l": "PRLR is phosphorylated at Ser-349 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160915", "l": "Receptor-mediated uptake of HA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30600", "l": "15-cis-phytoene + 3 A => 3 AH2 + all-trans-neurosporene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50561", "l": "acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635839", "l": "ULK3:SUFU dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22620", "l": "H(+) + L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH4(+)", "d": [], "t": []}, {"i": "EC:1.13.99.3", "l": "\"tryptophan 2'-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2509831", "l": "ITPA hydrolyses XTP to XMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30407", "l": "hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] = oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.97.1.12", "l": "\"photosystem I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75418", "l": "H2O + N-methylmyosmine <=> pseudooxynicotine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49568", "l": "2-glutathionyl-2-methylbut-3-en-1-ol = (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione", "d": [], "t": []}, {"i": "EC:4.4.1.34", "l": "\"isoprene-epoxide--glutathione S-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30869", "l": "(indol-3-yl)acetate + 2 H(+) + NADH => H2O + indole-3-acetaldehyde + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55573", "l": "4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine => 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705584", "l": "HMGCR dimer binds statins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863494", "l": "ASICs bind STOML3, (STOM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507868", "l": "Aquaporins passively transport water into cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10824", "l": "(S)-malate + NADP(+) = H(+) + NADPH + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28918", "l": "4-aminobutanoate(in) + H(+)(in) <=> 4-aminobutanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157933", "l": "NICD2 traffics to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417896", "l": "P2Y6 receptor can bind to UDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58246", "l": "ADP-D-ribose + L-lysyl-[protein] => H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42408", "l": "(2R)-2-phosphoglycerate + ATP = (2R)-2,3-bisphosphoglycerate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.2.16", "l": "\"2-phosphoglycerate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16192", "l": "3-(4-hydroxyphenyl)pyruvate + O2 <=> CO2 + homogentisate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62558", "l": "4-methylcatechol + CO2 => 3,4-dihydroxyphenylacetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64609", "l": "L-threonyl-[protein] + UTP => diphosphate + uridylyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18613", "l": "4-methoxybenzoate + AH2 + O2 = 4-hydroxybenzoate + A + formaldehyde + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.15", "l": "\"4-methoxybenzoate monooxygenase (O-demethylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43859", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19500", "l": "H(+) + L-aspartate <=> beta-alanine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047691", "l": "aspulvinone dimethylallyltransferase activity", "d": ["Catalysis of the reaction: aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71025", "l": "L-leucine(out) + L-phenylalanine(in) => L-leucine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9823934", "l": "OPTN binds TBK1 within the activated TLR4 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610732", "l": "GSK3 phosphorylates p-GLI3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10191", "l": "acetoacetyl-CoA + acetyl-CoA + H2O <=> (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.1.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12779", "l": "2-amino-4,7-dihydroxypteridine + chemical entity => 2-amino-4-hydroxypteridine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39256", "l": "(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0005550", "l": "pheromone binding", "d": ["Binding to a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624951", "l": "TNPO1 binds KIF17 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44834", "l": "CoA + O-tetradecanoyl-(R)-carnitine => (R)-carnitine + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015411", "l": "ABC-type taurine transporter transporter activity", "d": ["Enables the transfer of taurine from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62546", "l": "dihydroouabagenin + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22555", "l": "3'-phosphoadenylyl sulfate + an alcohol <=> adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49029", "l": "(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] => (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78961", "l": "1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43102", "l": "2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(44) in tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25525", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => 9alpha-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689544", "l": "UCHL5 binds INO80 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50643", "l": "2-(2-methylsulfanyl)ethylmalate <=> 3-(2-methylsulfanyl)ethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50972", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156930", "l": "GTP-binding activates eEF2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.139", "l": "\"pterocarpan synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70497", "l": "D-glucose(in) + 2 Na(+)(in) => D-glucose(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65323", "l": "2-oxoglutarate + chrodrimanin E + O2 <=> chrodrimanin A + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801109", "l": "CHM binds RGGT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48940", "l": "an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid", "d": [], "t": []}, {"i": "EC:3.4.13.19", "l": "\"membrane dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602484", "l": "Activation of proMMP11 by FURIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196773", "l": "COASY phosphorylates DP-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15880", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate <=> D-glutamate + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32280", "l": "allantoate + 2 H(+) + 2 H2O => (S)-ureidoglycolate + CO2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982637", "l": "Opsins binds G alpha-t (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042978", "l": "ornithine decarboxylase activator activity", "d": ["Binds to and increases ornithine decarboxylase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836435", "l": "p-PKR dimer phosphorylates SNCA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63625", "l": "hexadecanoyl-AMP + holo-[ACP] => AMP + H(+) + hexadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801195", "l": "STEAP3 binds BNIP3L (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16778", "l": "ATP + H2O + K(+)(out) => ADP + H(+) + K(+)(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168878", "l": "PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14758", "l": "2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone => 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445714", "l": "Aquaporin-3 passively transports water out of cell (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0030337", "l": "DNA polymerase processivity factor activity", "d": ["An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64849", "l": "(3Z)-hex-3-en-1-ol + benzoyl-CoA => (3Z)-hex-3-en-1-yl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23760", "l": "H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) = reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}, {"i": "EC:1.12.98.1", "l": "\"coenzyme F420 hydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16170", "l": "ATP + L-glutamate + NH4(+) => ADP + H(+) + L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49107", "l": "Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34221", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112434", "l": "Formation of DSIF complex  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51352", "l": "H2O + N-(9Z-octadecenoyl)-L-serine = (9Z)-octadecenoate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60205", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052628", "l": "4-hydroxybenzoate amino acid synthetase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + ATP + amino acid = 4-hydroxybenzoyl amino acid conjugate + AMP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64515", "l": "(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine <=> 6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13894", "l": "H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate => ADP + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30722", "l": "acetyl-CoA + propanoyl-CoA <=> 2-methyl-3-oxobutanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050465", "l": "nitroquinoline-N-oxide reductase activity", "d": ["Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62720", "l": "3 H(+) + 3 NADPH + 3 O2 + probetaenone I = betaenone B + 3 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41210", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32478", "l": "glycine + 3 S-adenosyl-L-methionine <=> glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34452", "l": "dTDP-6-deoxy-beta-L-talose => dTDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050589", "l": "leucocyanidin oxygenase activity", "d": ["Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42033", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36633", "l": "(2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+) => D-ribulose 1,5-bisphosphate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67490", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211247", "l": "Cleavage of DNA by DFF40 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24123", "l": "H(+) + leukotriene E4 + NADPH + O2 <=> 20-hydroxy-leukotriene E4 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818574", "l": "TASP1 cleaves KMT2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390087", "l": "WTS binds to SAV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43158", "l": "H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine => guanosine(9) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.281", "l": "\"GDP-4-dehydro-6-deoxy-D-mannose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40594", "l": "decanedioyl-CoA + H2O <=> CoA + decanedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9824979", "l": "XPO1 binds p-S69,73 MITF-M (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28264", "l": "3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP => 3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58357", "l": "2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 => CO2 + formaldehyde + L-arginyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68577", "l": "ATP + H2O + xanthine(out) => ADP + H(+) + phosphate + xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34436", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine => 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34573", "l": "H(+) + NADPH + presqualene diphosphate => C30 botryococcene + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29253", "l": "2 H(+)(in) + Na(+)(out) => 2 H(+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27284", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+) => 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47869", "l": "di-(9Z)-octadecenoylglycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76359", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78120", "l": "a 1,3-diacyl-2-(9Z,12Z-octadecadienoyl)-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base => a 1,3-diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74331", "l": "O-butanoyl-(R)-carnitine(in) = O-butanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65996", "l": "Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+) = methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine", "d": [], "t": []}, {"i": "EC:2.1.1.376", "l": "\"glycine betaine--corrinoid protein Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23820", "l": "GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.47", "l": "\"GDP-mannose 4,6-dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31951", "l": "9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.111", "l": "\"9beta-pimara-7,15-diene oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37950", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050649", "l": "testosterone 6-beta-hydroxylase activity", "d": ["Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22167", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a globoside Forssman (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56266", "l": "CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9833635", "l": "p-PKR dimer localizes to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12286", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + succinate => 3-hydroxy-3-methylglutarate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16845", "l": "acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31663", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}, {"i": "EC:2.6.1.34", "l": "\"UDP-N-acetylbacillosamine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12723", "l": "H(+) + S-methyl-5'-thioadenosine + spermidine => putrescine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38653", "l": "(9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791016", "l": "SFTPB binds itself (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55169", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) => [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9824582", "l": "MAPK1 phosphorylates SOX10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36844", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42216", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27903", "l": "caffeine + H2O + ubiquinone-0 => 1,3,7-trimethylurate + ubiquinol-0", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624133", "l": "ARL3:GTP binds the UNC119B complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16493", "l": "glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.42", "l": "\"glycerol-1,2-cyclic-phosphate 2-phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032770", "l": "Translocation of YAP1 to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380930", "l": "Phosphorylated AMPK binds AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9861616", "l": "DLD dimer dehydrogenates dihydrolipoyl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189406", "l": "4 PBGs bind to form HMB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52845", "l": "3,4-dihydroxybenzoate + UDP-alpha-D-glucose => 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51742", "l": "a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61427", "l": "cis-cis-nepetalactol + NAD(+) <=> cis-cis-nepetalactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66026", "l": "[collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O => hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72265", "l": "chloride(in) + oxalate(out) => chloride(out) + oxalate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788628", "l": "p-Y-STATs dissociate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871266", "l": "YAP1 binds TEAD3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29683", "l": "alpha-maltohexaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltopentaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033932", "l": "1,3-alpha-L-fucosidase activity", "d": ["Catalysis of the hydrolysis of (1->3) linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.134", "l": "\"galactolipid O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27621", "l": "(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate <=> di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391372", "l": "GNRHR binds GNRH1,2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70248", "l": "N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose => beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950113", "l": "IL12A binds IL12B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791150", "l": "Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709109", "l": "DHFR dimer binds DHFR inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810392", "l": "TMEM55B translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77240", "l": "pre-pseudomonine => pseudomonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30192", "l": "15-cis-phytoene + plastoquinone-9 => 15,9'-di-cis-phytofluene + plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45856", "l": "3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928617", "l": "EPHB2 binds KALRN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52585", "l": "chenodeoxycholoyl-CoA + NAD(+) => 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76430", "l": "(2R,9S)-annullatin H + A <=> (2R)-annullatin F + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77498", "l": "acetophenone + hydrogen cyanide <=> (2S)-2-hydroxy-2-phenylpropanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374251", "l": "DARC  is a non-specific receptor for many chemokines (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466392", "l": "NRF1:p-PPARGC1A, NRF2 bind the TFB2M promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72074", "l": "L-histidyl-[protein] + NAD(+) <=> H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362416", "l": "Frataxin binds iron (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856157", "l": "LAG3 (CD233) binds MHC II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9846501", "l": "B3GNT5 transfers GlcNAc to LacCer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9687625", "l": "ATP binds MLKL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27498", "l": "3'-O-methyltricetin + S-adenosyl-L-methionine => 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031766", "l": "type 3 galanin receptor binding", "d": ["Binding to a type 3 galanin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36381", "l": "4alpha-methylzymosterol + NADP(+) => 3-dehydro-4alpha-methylzymosterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60928", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30334", "l": "all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47560", "l": "a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51716", "l": "ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71926", "l": "2 Na(+)(out) + taurochenodeoxycholate(out) <=> 2 Na(+)(in) + taurochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20909", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25670", "l": "sucrose + UDP-alpha-D-galactose = H(+) + loliose + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.n2", "l": "\"loliose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848338", "l": "PNPLA4 hydrolyzes TAG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37162", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050026", "l": "L-glycol dehydrogenase activity", "d": ["Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77081", "l": "Formation of the CE:GMP intermediate complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451283", "l": "kainate receptor binds glutamate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987015", "l": "IL20 binds IL20RA:JAK1:IL20RB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50682", "l": "N-terminal L-glutamyl-[protein] + NH4(+) => H2O + N-terminal L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40209", "l": "(3S)-hydroxytetradecanedioyl-CoA => (2E)-tetradecenedioyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53928", "l": "a tertiary amine + S-adenosyl-L-methionine = a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67433", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25569", "l": "ATP + beta-D-ribosylnicotinate => ADP + H(+) + nicotinate beta-D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26134", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9695949", "l": "SPHK2 phosphorylates sphingoid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60347", "l": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794346", "l": "NRXNs bind NLGNs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18324", "l": "2-oxoglutarate + L-leucine <=> 4-methyl-2-oxopentanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37466", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102317", "l": "4-methylaminobutyrate oxidase (demethylating) activity", "d": ["Catalysis of the reaction: 4-(methylamino)butyric acid + O2 + H2O = gamma-aminobutyric acid + formaldehyde + hydrogen peroxide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45550", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] => phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32148", "l": "H2O + sepiapterin => 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32771", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate = 2,6-dioxo-6-phenylhexa-3-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78754", "l": "(R)-carnitine + a fatty acyl-CoA <=> a fatty acyl-L-carnitine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76256", "l": "a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA => (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25581", "l": "alpha-L-fucose => beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814734", "l": "CDSN binds the cornified envelope (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78653", "l": "(S)-disulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphate => ATP + S-disulfanyl-L-cysteine + tRNA(Cys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66506", "l": "1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32612", "l": "(6E)-8-hydroxygeranial + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373074", "l": "Receptor CCR9  binds CCL25 ligand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21919", "l": "an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O <=> an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446694", "l": "IRAK4 phosphorylates IRAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32300", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADH => 2 diphosphate + NAD(+) + squalene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17077", "l": "H2O + N,N-dimethylglycine + O2 = formaldehyde + H2O2 + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75311", "l": "D-serine(in) + L-alanine(out) + Na(+)(out) = D-serine(out) + L-alanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65251", "l": "AH2 + 5 H(+) + 5 malonyl-CoA <=> 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33826", "l": "3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH <=> NAD(+) + tetrahydro-4-hydroxyphenylpyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419033", "l": "NCAM1 binds FGFR-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18514", "l": "D-mannitol + O2 => D-mannose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218804", "l": "p38 MAPK activation by VEGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77468", "l": "butan-2-one + hydrogen cyanide => 2-hydroxy-2-methylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9865412", "l": "TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23772", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.58", "l": "\"2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614591", "l": "Excess cysteine yields lanthionine and H2S (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9615249", "l": "ARBs bind AGRT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70842", "l": "L-arginine(in) + L-histidine(out) + Na(+)(out) <=> L-arginine(out) + L-histidine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.22", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692738", "l": "HRH2 binds HRH2 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25777", "l": "scyllo-inosose => scyllo-inosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29881", "l": "ADP + H(+) + L-arginine(in) + phosphate => ATP + H2O + L-arginine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45083", "l": "3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine <=> ADP + dapdiamide E + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78397", "l": "biliverdin IXbeta + H(+) + NADPH => bilirubin IXbeta + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34204", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 => aureusidin 6-O-beta-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16300", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.52", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114284", "l": "Release of Cytochrome c from mitochondria (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49898", "l": "5,10-dihydrophenazine-1,6-dicarboxylate => (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869683", "l": "oxPL binds LBP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981892", "l": "Active G alpha (z) binds RGS proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419003", "l": "Interaction of Nectins with Afadin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19299", "l": "ADP + carnosine + H(+) + phosphate => ATP + beta-alanine + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68105", "l": "all-trans-zeaxanthin + O2 => (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22322", "l": "D-maltose + 2 phosphate => 2 alpha-D-glucose 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198756", "l": "ERK1/2 phosphorylates MSK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75589", "l": "erinacine Q2 + H(+) + UDP => 11-O-acetylcyathatriol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23804", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}, {"i": "EC:5.4.2.3", "l": "\"phosphoacetylglucosamine mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673757", "l": "Ligand-independent dimerization of cytosolic PDGFRA and PDGFRB fusion proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951690", "l": "Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34535", "l": "H(+) + hexadecanoyl-CoA + L-alanine = 1-deoxy-3-dehydrosphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14177", "l": "(R)-amygdalin + H2O = (R)-prunasin + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.117", "l": "\"amygdalin beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426032", "l": "DAG is metabolized by DAGL to 2-AG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848713", "l": "PTK6 binds BCAR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871227", "l": "RET binds GFRA4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36878", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28414", "l": "gamma-L-glutamylputrescine + H2O + O2 = 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627350", "l": "SMAC (DIABLO) binds XIAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48065", "l": "a ganglioside GD1b (d18:1(4E)) + H2O => a ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11525", "l": "5beta-cholestan-3-one + NADP(+) => cholest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58435", "l": "(E)-4-oxonon-2-en-1-ol + NADP(+) <=> (E)-4-oxonon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222237", "l": "SMYD2 methylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67918", "l": "AMP + NH4(+) => adenosine 5'-phosphoramidate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56481", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66253", "l": "ATP + CoA + IC-asc-C7 => AMP + diphosphate + IC-asc-C7-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009072", "l": "STAT3 phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55907", "l": "7-chloro-L-tryptophan + chloride + FADH2 + O2 <=> 6,7-dichloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77863", "l": "(2S)-3-phenyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O = 2-dehydro-D-glucose + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37403", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67154", "l": "L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28750", "l": "NH4(+)(in) <=> NH4(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.42", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47566", "l": "a ganglioside GA2 (d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004512", "l": "inositol-3-phosphate synthase activity", "d": ["Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071885", "l": "N-terminal protein N-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser."], "t": []}, {"i": "EC:2.1.1.244", "l": "\"protein N-terminal methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73206", "l": "D-glucose(out) + H(+)(in) <=> D-glucose(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16570", "l": "2-oxoglutarate + L-lysyl-[collagen] + O2 => (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140081", "l": "glycosylated region protein binding", "d": ["Binding to a glycosylated region of a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56684", "l": "dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine", "d": [], "t": []}, {"i": "EC:1.14.19.61", "l": "\"dihydrorhizobitoxine desaturase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2533950", "l": "Fibronectin degradation by MMP14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32545", "l": "1,8-cineole + diphosphate => (2E)-geranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68741", "l": "7-oxocholesterol + H(+) + NADPH => 7alpha-hydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26322", "l": "resorcinol + S-adenosyl-L-methionine => 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10081", "l": "dihydrophloroglucinol + NADP(+) => 1,3,5-trihydroxybenzene + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47841", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine => (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61875", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 <=> 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44094", "l": "AMP + diphosphate + nonadecanoyl-CoA => ATP + CoA + nonadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448678", "l": "CTSG cleaves CASP1(1-404) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633295", "l": "TP53 binds the NDRG1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4420206", "l": "Phosphorylation of SRC-1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5229283", "l": "LCNs bind lipids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963872", "l": "VD3 translocates from ER membrane to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70553", "l": "3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30617", "l": "2 AH2 + all-trans-zeta-carotene => 15-cis-phytoene + 2 A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418904", "l": "A1 and A3 receptors bind adenosine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32625", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => L-threo-tetrahydrobiopterin + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41551", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0008937", "l": "ferredoxin-NAD(P) reductase activity", "d": ["Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390835", "l": "DRD1,5 bind DA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047876", "l": "endoglycosylceramidase activity", "d": ["Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112703", "l": "PTPN11 is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19389", "l": "(E)-ferulate + ATP + CoA = (E)-feruloyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943279", "l": "GGT dimers hydrolyse GSH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1474266", "l": "Formation of collagen fibrils (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690493", "l": "RHOB binds effectors on endosomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39947", "l": "a 1,3-diacyl-sn-glycerol + H2O = a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030380", "l": "interleukin-17E receptor binding", "d": ["Binding to an interleukin-17E receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22552", "l": "3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.2", "l": "\"alcohol sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74264", "l": "n H(+)(out) + spermine(in) => n H(+)(in) + spermine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0043855", "l": "cyclic nucleotide-activated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696822", "l": "AKR1B15 reduces EST17b to E1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53684", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928641", "l": "PAK binds RAC and bPIX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16523", "l": "NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109701", "l": "PDPK1 binds PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730872", "l": "Activation of Calcineurin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10682", "l": "D-proline => L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77893", "l": "(1-deoxy-D-fructos-1-yl)amine + 6-amino-2-oxohexanoate + H2O2 => H2O + N(2)-(1-deoxy-beta-D-fructopyranos-1-yl)-L-lysine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43844", "l": "(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 = (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70855", "l": "L-glutamine(out) + L-serine(in) + Na(+)(out) = L-glutamine(in) + L-serine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-844619", "l": "AIM2 binds dsDNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797090", "l": "CCNK binds CDK12 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34125", "l": "CoA + H(+) + olivetolate => 3,5,7-trioxododecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32672", "l": "ATP + UDP-N-acetyl-alpha-D-glucosamine => ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44570", "l": "2-all-trans-hexaprenylphenol + CO2 => 4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34364", "l": "H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP => diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76847", "l": "(R)-sec-butylamine + H2O + NAD(+) = butan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51547", "l": "D-ribulose <=> D-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051525", "l": "NFAT protein binding", "d": ["Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74682", "l": "UDP-beta-L-arabinofuranose(in) + UMP(out) <=> UDP-beta-L-arabinofuranose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28787", "l": "4-hydroxy-L-threonine + ATP = 4-(phosphooxy)-L-threonine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42008", "l": "5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37443", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70917", "l": "guanosine(out) + H(+)(out) => guanosine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64977", "l": "8-oxo-dGTP + 2 H2O => 8-oxo-dGMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052862", "l": "glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group", "d": ["Catalysis of the endohydrolysis of (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33878", "l": "cholesteryl (9Z-octadecenoate) + H2O <=> (9Z)-octadecenoate + cholesterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47203", "l": "(24S)-7alpha-dihydroxycholesterol + NAD(+) <=> (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203973", "l": "Vesicle budding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198714", "l": "ERK5 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56697", "l": "D-ribulose 5-phosphate + L-tryptophan => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68104", "l": "all-trans-zeaxanthin + O2 = (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44861", "l": "(R)-carnitine + 4,8-dimethylnonanoyl-CoA => CoA + O-4,8-dimethylnonanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16224", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030945", "l": "protein tyrosine phosphatase activity, via thiol-phosphate intermediate", "d": ["The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78042", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1-O-alkyl-3-acylglycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353434", "l": "Formation of Pol zeta complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218821", "l": "PDK1 phosphorylates PKC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35739", "l": "cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] = 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone", "d": [], "t": []}, {"i": "EC:1.14.15.6", "l": "\"cholesterol monooxygenase (side-chain-cleaving)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24097", "l": "isoorientin + S-adenosyl-L-methionine => H(+) + isoscoparin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839388", "l": "TGFBR3 translocation to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11528", "l": "2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41983", "l": "3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.96", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052925", "l": "dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity", "d": ["Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655341", "l": "Activated FGFR4 mutants phosphorylate PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008679", "l": "2-hydroxy-3-oxopropionate reductase activity", "d": ["Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029155", "l": "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050172", "l": "phenylalanine 2-monooxygenase activity", "d": ["Catalysis of the reaction: L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687088", "l": "PKA phosphorylates MAPKAPK5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76175", "l": "glycyl-L-glutamate(out) + 3 H(+)(out) = glycyl-L-glutamate(in) + 3 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20518", "l": "UDP-N-acetyl-alpha-D-glucosamine => UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102914", "l": "N-methyl-3-aminomethylindole N-methyltransferase activity", "d": ["Catalysis of the reaction: N-methyl-3-aminomethylindole + S-adenosyl-L-methionine = H+ + gramine + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010280", "l": "UDP-L-rhamnose synthase activity", "d": ["Catalysis of the reaction: UDP-D-glucose + NADPH + H+ = UDP-L-rhamnose + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047983", "l": "homoglutathione synthase activity", "d": ["Catalysis of the reaction: beta-alanine + L-gamma-glutamyl-L-cysteine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60481", "l": "2 UTP => c-di-UMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296045", "l": "Activation of Potassium transport channels (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797553", "l": "Protein 4.1 binds CASK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63987", "l": "5-hydroxyuridine + ATP <=> 5-hydroxyuridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035274", "l": "diphenyl phthalate binding", "d": ["Binding to diphenyl phthalate, C(20)H(14)O(4)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15297", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.133", "l": "\"xylosylprotein 4-beta-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25049", "l": "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O <=> (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54783", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine <=> [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20683", "l": "H(+) + O-beta-D-glucosyl-cis-zeatin + UDP => cis-zeatin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139906", "l": "Activation of BAD by calcineurin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38465", "l": "a 1,2-diacyl-sn-glycerol + CoA => a 1-acyl-sn-glycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218836", "l": "PTK2beta binds alphaVbeta3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43062", "l": "beta-D-glucose 1-phosphate + glycerol => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140853", "l": "cholesterol-protein transferase activity", "d": ["Catalysis of the reaction: cholesterol + glycyl-L-cysteinyl-[protein] + H+ = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]."], "t": []}, {"i": "RHEA:59504", "l": "cholesterol + glycyl-L-cysteinyl-[protein] + H(+) = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70429", "l": "2-phenylacetate + CoA + H(+) => H2O + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791071", "l": "Expression of PLA2G4B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33140", "l": "L-alanine(out) + L-aspartate(in) => L-alanine(in) + L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42625", "l": "(Z)-3-ureidoacrylate + H(+) + H2O => (Z)-3-aminoacrylate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28805", "l": "3-dehydro-L-gulonate 6-phosphate => H2O + L-ascorbate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27281", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12469", "l": "avenacoside A + H2O => 26-desgluco-avenacoside A + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032778", "l": "P-type cobalt transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Co2+(out) = ADP + phosphate + Co2+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39502", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA <=> (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827872", "l": "Expression of PRDM1 in primordial germ cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071566", "l": "UFM1 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975134", "l": "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37985", "l": "2,3-dimethyl-6-phytylbenzene-1,4-diol => gamma-tocopherol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50874", "l": "(5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate => (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51448", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015129", "l": "lactate transmembrane transporter activity", "d": ["Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67080", "l": "a very long-chain fatty acid(in) + ATP + H2O = a very long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29973", "l": "2'-deoxyinosine(out) + H(+)(out) => 2'-deoxyinosine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68265", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O => (6S)-5,6,7,8-tetrahydrofolate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40999", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77954", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate <=> 1-(9Z-octadecenoyl)-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9676257", "l": "Formation of the SET1A complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33496", "l": "all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate => 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389352", "l": "Translocation of Vav1 to CD28 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70971", "l": "ACO2 isomerizes citrate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77174", "l": "biocytin + H2O <=> biotin + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674022", "l": "BRAP autoubiquitinates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47800", "l": "4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid = an aromatic oxo-acid + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68234", "l": "L-cysteine(out) + Na(+)(out) => L-cysteine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44248", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22135", "l": "ATP + D-maltose(out) + H2O <=> ADP + D-maltose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68588", "l": "(6R)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine = (6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+)", "d": [], "t": []}, {"i": "EC:2.1.2.14", "l": "\"GDP-perosamine N-formyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15408", "l": "(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) <=> [(3R)-hydroxybutanoate](n+1) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61066", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24978", "l": "(1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444047", "l": "Receptor FFAR3 binds carboxylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707516", "l": "FeHM dissociates from MetHb (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683925", "l": "ULK1 is dephosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49222", "l": "CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate => 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77316", "l": "glyoxylate + N(omega),N('omega)-dimethyl-L-arginine => 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047457", "l": "exo-(1,4)-alpha-D-glucan lyase activity", "d": ["Catalysis of the reaction: linear alpha-D-glucan = 1,5-anhydro-D-fructose + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784598", "l": "NPPA(124-151) binds NPR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879222", "l": "MDP:NLRP1 binds ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31105", "l": "folate + H(+) + NADPH => 7,8-dihydrofolate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13755", "l": "2-oxoglutarate + H(+) + L-glutamine + NADH => 2 L-glutamate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19924", "l": "D-ribitol 5-phosphate + NADP(+) <=> D-ribulose 5-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16336", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] <=> diphosphate + holo-[citrate lyase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9861563", "l": "CTLH E3 ligase ubiquitinates LDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67645", "l": "ATP + dZDP => ADP + dZTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102096", "l": "decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity", "d": ["Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = dTDP(3-) + alpha-L-Rhap-(1->3)-alpha-D-GlcpNAc-1-diphospho-trans,octacis-decaprenol + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876446", "l": "p-ULK1 phosphorylates DENND3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787737", "l": "CSF3R binds CSF3 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38068", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA => 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052797", "l": "4-O-methyl-glucuronoyl methylesterase activity", "d": ["Catalysis of the reaction: [X]-4-O-methyl-D-glucuronic acid + H2O = [X]-OH + methyl-D-glucuronic acid. This reaction is the hydrolysis of the ester linkage between 4-O-methyl-D-glucuronic acid (MeGlcA) and an alcohol (-OH) group attached to a molecule, denoted here as [X]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53163", "l": "H2O + N-acyl-sn-glycero-3-phosphoethanolamine <=> an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351849", "l": "Caspase-mediated cleavage of Etk (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14798", "l": "2-dehydro-3-deoxy-D-gluconate + ATP => 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51528", "l": "H(+) + vanillate = CO2 + guaiacol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37725", "l": "1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55358", "l": "13-cis-retinol => 11-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050277", "l": "sedoheptulokinase activity", "d": ["Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H+ + sedoheptulose 7-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693609", "l": "ATM phosphorylates TP53 at S15 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56801", "l": "apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide => cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871266", "l": "YAP1 binds TEAD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76759", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] = 1,5-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75128", "l": "neopinone => codeinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390673", "l": "CHRM2,4 bind acetylcholine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856157", "l": "LAG3 (CD233) binds MHC II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42121", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32165", "l": "AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine => ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641147", "l": "DACT1 binds DVL2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49271", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791319", "l": "NID1 degradation by MMP19 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28317", "l": "baicalein + UDP-alpha-D-glucuronate <=> baicalin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20339", "l": "(R)-lactate + H(+) + sulfate => (R)-2-O-sulfolactate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59622", "l": "4-aminobutanoate + L-lysine => H2O + N(2)-(4-aminobutanoyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389862", "l": "Conversion of glyoxylate to oxalate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76536", "l": "FAD(in) => FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62115", "l": "(3S)-3-hydroxy-D-aspartate <=> H2O + iminosuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15634", "l": "3,4-dihydroxyphenylacetate + O2 => 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45954", "l": "H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP => L-asparaginyl-[protein] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77094", "l": "Formation of cap binding complex (CBC) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203712", "l": "eNOS associates with Caveolin-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451819", "l": "YKI binds to HTH and TSH and activates transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199144", "l": "Nectin 2 binds CD226 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18772", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate <=> 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16361", "l": "2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19915", "l": "a 3-oxoacyl-[ACP] + H(+) + NADH => a (3R)-hydroxyacyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9842835", "l": "KRAB-ZFP binds retroelement DNA in chromatin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047666", "l": "ammonia kinase activity", "d": ["Catalysis of the reaction: ATP + NH4 = ADP + 3 H+ + phosphoramidate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618328", "l": "ATAT acetylates microtubules (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0061594", "l": "6-deoxy-6-sulfofructose kinase activity", "d": ["Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60164", "l": "a guanosine in RNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759189", "l": "NFE2L2-dependent PRDX1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25580", "l": "alpha-L-fucose = beta-L-fucose", "d": [], "t": []}, {"i": "EC:5.1.3.29", "l": "\"L-fucose mutarotase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11030", "l": "ADP + D-mannose 6-phosphate + H(+) => ATP + D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676161", "l": "PI(3,5)P2 transports from the late endosome membrane to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47548", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oate = 3-oxochola-4,6-dien-24-oate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20019", "l": "5,10-methylenetetrahydromethanopterin + H(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687107", "l": "MAPK4,6 translocate to nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15233", "l": "Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite", "d": [], "t": []}, {"i": "EC:1.7.2.1", "l": "\"nitrite reductase (NO-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19722", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77927", "l": "H2O + N-(4-aminobutylpyrrolinium) ion + O2 = H2O2 + N-(4-oxobutylpyrrolinium) ion + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019834", "l": "phospholipase A2 inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of phospholipase A2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202717", "l": "Heterodimerization of CEACAMs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202248", "l": "Phosphorylation of PLC-gamma1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.-", "l": "\"Acid--ammonia (or amine) ligases (amide synthases)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682011", "l": "LC3 binds ATG7 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52892", "l": "H2O + NADP(+) + nitrosobenzene = H(+) + NADPH + nitrobenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102682", "l": "cytokinin riboside 5'-monophosphate phosphoribohydrolase activity", "d": ["Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O = N(6)-dimethylallyladenine + D-ribose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78806", "l": "a 2-iminocarboxylate + H2O <=> a 2-oxocarboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26443", "l": "a ubiquinone + ethanol => a ubiquinol + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22970", "l": "butanoyl-CoA + H(+) + NADH => butanal + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13485", "l": "2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.75", "l": "\"cysteine-conjugate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70205", "l": "5,6-dihydroxyindole-N-methyl => N-methyldopaminechrome", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34762", "l": "ATP + glycerol 2-phosphate(out) + H2O <=> ADP + glycerol 2-phosphate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12037", "l": "(S)-3-(imidazol-5-yl)lactate + NAD(+) => 3-(imidazol-5-yl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70815", "l": "H(+)(in) + L-histidine(in) + L-ornithine(out) = H(+)(out) + L-histidine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602473", "l": "Autocatalytic activation of MMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937792", "l": "RUNX3 binds SRC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66114", "l": "(2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate => 2-oxobutanoate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.923250621671642", "identifiers": [{"i": "GO:0016824", "l": "hydrolase activity, acting on acid halide bonds", "d": ["Catalysis of the hydrolysis of any acid halide bond."], "t": []}, {"i": "EC:3.8.-.-", "l": "\"Acting on halide bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50844", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972965", "l": "POU5F1 (OCT4), SOX2, NANOG bind the TSC22D1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27842", "l": "9H-carbazole + H(+) + NADPH + O2 = 2'-aminobiphenyl-2,3-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46374", "l": "a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22897", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30724", "l": "A + 2 ADP + H(+) + NH4(+) + 2 phosphate => AH2 + 2 ATP + H2O + hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34843", "l": "7,8-dihydromonapterin 3'-triphosphate + 3 H2O = 7,8-dihydromonapterin + 2 H(+) + 3 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34425", "l": "(+)-lariciresinol + H(+) + NADPH => (-)-secoisolariciresinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170015", "l": "carbon dioxide receptor activity", "d": ["Combining with carbon dioxide to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388596", "l": "Melanocortin receptors bind melanocortins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61289", "l": "5-deoxy-D-ribose + ATP => 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010486", "l": "manganese:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76475", "l": "hexadecan-1-ol + O2 = H2O2 + hexadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14358", "l": "ATP + riboflavin => ADP + FMN + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005185", "l": "neurohypophyseal hormone activity", "d": ["The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26095", "l": "H2O + limonene 1,2-epoxide + NAD(+) => (4R)-limonene + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2077424", "l": "Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47842", "l": "(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate => [5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.105", "l": "\"2-hydroxyisoflavanone dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55971", "l": "(+)-kolavelool + S-adenosyl-L-methionine <=> (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10502", "l": "3-ethylmalate + CoA + H(+) => butanoyl-CoA + glyoxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70346", "l": "chloride + L-tyrosine + NADP(+) <=> 3-chloro-L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168860", "l": "Membrane fusion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56846", "l": "nocamycin I + S-adenosyl-L-homocysteine => nocamycin E + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78068", "l": "a triacylglycerol + all-trans-retinol => a 1,3-diacylglycerol + an all-trans-retinyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12975", "l": "2 ADP => AMP + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64303", "l": "3-phenylpropylamine + pyruvate <=> 3-phenylpropanal + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63794", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042933", "l": "chrysobactin transmembrane transporter activity", "d": ["Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374251", "l": "DARC  is a non-specific receptor for many chemokines (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196017", "l": "Dynamin is recruited to the gap junction plaque (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692794", "l": "p-S215 FOXO1 positively regulates RAG gene expression  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22580", "l": "(S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-dienoate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.80", "l": "\"2-oxopent-4-enoate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36064", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + kunzeaol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55900", "l": "chloride + FADH2 + L-tryptophan + O2 = 6-chloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12700", "l": "ATP + dGMP <=> ADP + dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75661", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate => (11Z,14Z)-eicosadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41003", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74442", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) <=> a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9866217", "l": "HCCS inserts heme into cytochrome c (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19082", "l": "1-haloalkane + H2O => a halide anion + a primary alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49473", "l": "trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose => H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56508", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12678", "l": "AH2 + Latia luciferin + 2 O2 => A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928615", "l": "EFNBs bind SFKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13142", "l": "2-methylpropanoyl-CoA => butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9825704", "l": "AKT3 phosphorylates TBX3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784861", "l": "HSPG binds LPL dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9846477", "l": "A4GALT transfers galactose to LacCer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12971", "l": "an alcohol + H(+) + sn-glycerol 3-phosphate => a sn-glycero-3-phosphodiester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102144", "l": "carboxyspermidine dehydrogenase II activity", "d": ["Catalysis of the reaction: carboxyspermidine + H2O + NADP = L-aspartic acid 4-semialdehyde betaine + 1,4-butanediammonium + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9844015", "l": "MPHOSPH8 (MPP8) in HUSH complex binds histone H3 trimethyl-lysine 9 (H3K9me3) in L1HS,L1PA2,3 heterochromatin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018615", "l": "2-indanone monooxygenase activity", "d": ["Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37970", "l": "galactitol + NADP(+) <=> D-galactose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26329", "l": "(8S)-8-amino-7-oxononanoate + L-lysine = (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate", "d": [], "t": []}, {"i": "EC:2.6.1.105", "l": "\"lysine--8-amino-7-oxononanoate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62745", "l": "H2O + mevastatin => (S)-2-methylbutanoate + compactin diol lactone + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227783", "l": "Phosphorylation of IKKs complex mediated by MEKK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36637", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine => 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17477", "l": "precorrin-6B + 2 S-adenosyl-L-methionine = CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.132", "l": "\"precorrin-6B C(5,15)-methyltransferase (decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.1", "l": "\"non-specific serine/threonine protein kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004503", "l": "tyrosinase activity", "d": ["Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10759", "l": "ATP + phosphate + pyruvate <=> AMP + diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51403", "l": "octadecanoyl-CoA + serotonin <=> CoA + H(+) + N-octadecanoyl-serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23893", "l": "3-nitropropanoate + NADP(+) => 3-nitroacrylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202692", "l": "PIP3 binds to RhoA and activates it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78318", "l": "ADP + ATP <=> adenosine 5'-tetraphosphate + AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63712", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.320", "l": "\"benzil reductase [(S)-benzoin forming]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28716", "l": "(R)-malate(in) + 2 H(+)(in) => (R)-malate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10126", "l": "benzyl acetate + H2O + NADP(+) => H(+) + NADPH + O2 + phenylacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046175", "l": "Further sulfation on galactose residues produces KSPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75755", "l": "(10E)-octadecenoate + H2O = 10-hydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.78", "l": "\"(R)-3-[(carboxymethyl)amino]fatty acid dioxygenase/decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71379", "l": "D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) = D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14694", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33932", "l": "all-trans-zeaxanthin + O2 => (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211191", "l": "Association of DFF with alpha:beta importin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373746", "l": "SEMA4D interacts with CD45 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211247", "l": "Cleavage of DNA by DFF40 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050392", "l": "vicianin beta-glucosidase activity", "d": ["Catalysis of the reaction: (R)-vicianin + H2O = mandelonitrile + vicianose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27307", "l": "A + D-proline => 1-pyrroline-2-carboxylate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66493", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.431", "l": "\"D-xylose reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73442", "l": "(2S)-naringenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-carthamidin-4',7-dimethyl ether + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24703", "l": "NAD(+) + UDP-alpha-D-glucuronate => CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033939", "l": "xylan alpha-1,2-glucuronosidase activity", "d": ["Catalysis of the hydrolysis of alpha-D-(1->2)-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799246", "l": "CHEK1 phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72706", "l": "UDP-alpha-D-galactose(in) + UMP(out) <=> UDP-alpha-D-galactose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78279", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + somaliensene A", "d": [], "t": []}, {"i": "EC:4.2.3.216", "l": "\"somaliensene A synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322429", "l": "XIAP monoubiquinates TLE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928576", "l": "RHOA:GTP binds ROCK, activating it (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11588", "l": "A + H2O + isoquinoline = AH2 + isoquinolin-1(2H)-one", "d": [], "t": []}, {"i": "EC:1.3.99.16", "l": "\"isoquinoline 1-oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102879", "l": "(+)-thujopsene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-thujopsene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013110", "l": "RHOC binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29311", "l": "FMNH2 + O2 + sulfoacetate = FMN + glyoxylate + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41500", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54636", "l": "(13E)-labda-7,13-dien-15-yl diphosphate = diphosphate + labda-7,13(16),14-triene", "d": [], "t": []}, {"i": "EC:4.2.3.192", "l": "\"labda-7,13(16),14-triene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22728", "l": "H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate", "d": [], "t": []}, {"i": "EC:2.9.1.1", "l": "\"L-seryl-tRNA(Sec) selenium transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18910", "l": "2,4,6-trichlorophenol + S-adenosyl-L-methionine => 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750226", "l": "NLRC5 binds IKBKB and CHUK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25379", "l": "2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24677", "l": "ATP + cytidine <=> ADP + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68456", "l": "(S)-3-hydroxyglutaryl-CoA = (2E)-glutaconyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31092", "l": "acetyl-CoA + dodecanoyl-CoA => 3-oxotetradecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61227", "l": "H2O + L-asparagine + O2 <=> 2-oxosuccinamate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54469", "l": "1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41654", "l": "2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+) => aclacinomycin S + dTDP-2-deoxy-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950218", "l": "Expression of Moesin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199093", "l": "CXADR binds to AMICA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15409", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine = 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": [], "t": []}, {"i": "EC:2.3.1.147", "l": "\"glycerophospholipid arachidonoyl-transferase (CoA-independent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23437", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O => 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748996", "l": "GST dimers cleave AZA to 6MP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433606", "l": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.182", "l": "\"taxoid 7beta-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76086", "l": "(11R)-carlactone + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-19-hydroxycarlactone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22822", "l": "3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69744", "l": "(S)-2-benzylsuccinate + succinyl-CoA => (S)-2-benzylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688797", "l": "ATXN3 family cleave Ub chains (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50814", "l": "1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60871", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O <=> a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251555", "l": "Expression of AXIN1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851988", "l": "BTN2A2 binds T cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19383", "l": "2-oxoglutarate + CO2 => (S)-oxalosuccinate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29963", "l": "H(+)(in) + inosine(in) = H(+)(out) + inosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483219", "l": "PC is exchanged with PI by PITPNB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61708", "l": "holo-[peptidyl-carrier protein] + L-seryl-5'-AMP = AMP + L-seryl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190265", "l": "FGFR4 binds to FGF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103044", "l": "ribosomal protein S6 glutamate-glutamate ligase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + a [protein] C-terminal L-glutamate = ADP + hydrogenphosphate + H+ + a [protein] with C-terminal alpha-L-glutamate-alpha-L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17360", "l": "O2 + 2 R'C(R)SH <=> H2O2 + R'C(R)S-S(R)CR'", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654625", "l": "Activated FGFR3 binds SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12048", "l": "3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate", "d": [], "t": []}, {"i": "EC:2.8.3.6", "l": "\"3-oxoadipate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814695", "l": "PERP binds desmosomes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140566", "l": "histone reader activity", "d": ["A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24910", "l": "L,L-cystathionine = 2-aminobut-2-enoate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165131", "l": "GEF dissociates from DRheb-GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29926", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686410", "l": "BLM mediates dissolution of double Holliday junction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449058", "l": "Interleukin-1 family are secreted (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73010", "l": "D-arabinose 5-phosphate <=> D-glyceraldehyde 3-phosphate + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788611", "l": "HYKK phosphorylates 5HLYS (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757688", "l": "SERPINA6 binds PREDN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58176", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH = all-trans-lycopaoctaene + 2 diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9652264", "l": "ERBB2 binds TKIs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11156", "l": "H2O + L-valine + NADP(+) = 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.1.8", "l": "\"valine dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56126", "l": "AH2 + diphosphate + nonaflavuxanthin => A + all-trans-lycopene + dimethylallyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74472", "l": "(-)-4'-methoxycyclopeptine + 2-oxoglutarate + O2 => (Z)-4'-methoxydehydrocyclopeptine + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.5", "l": "\"deoxyribonuclease X\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75901", "l": "1-acyl-sn-glycero-3-phospho-N-acyl-L-serine + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-N-acyl-L-serine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10886", "l": "acetaldehyde + desmosterol => (24R,24(1)R)-fucosterol epoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14823", "l": "L-ribulose => beta-L-arabinopyranose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5580269", "l": "Defective CYP11A1 does not cleave 20a,22b-DHCHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051007", "l": "squalene-hopene cyclase activity", "d": ["Catalysis of the reaction: squalene = hop-22(29)-ene."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0106260", "l": "DNA-DNA tethering activity", "d": ["Bridging together two regions of a DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39457", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77068", "l": "Activation of GT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n6", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9737780", "l": "MTTP binds lomitapide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67789", "l": "2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.123", "l": "\"[cytochrome c]-methionine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69166", "l": "2 H(+) + N-(2-carboxyethyl)putrescine + NADH => H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55829", "l": "cortisol + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202692", "l": "PIP3 binds to RhoA and activates it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62577", "l": "ATP + H2O + L-cystine(out) => ADP + H(+) + L-cystine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849797", "l": "Membrane proteases cleave Profilaggrin producing Filaggrin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9794523", "l": "SLC22A1 transports Cipro into renal cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71065", "l": "L-arginine(out) + L-histidine(in) => L-arginine(in) + L-histidine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578712", "l": "Importin-8 binds AGO2:miRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74283", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA = a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50375", "l": "an N-acylsphingoid base 1-phosphate(in) <=> an N-acylsphingoid base 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70501", "l": "PC carboxylates PYR to OA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14450", "l": "chlorophyllide a + NADP(+) => 3,8-divinyl chlorophyllide a + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70583", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35022", "l": "L-threonine(in) <=> L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26029", "l": "3-aminopropanal + H2O2 + N-acetylputrescine => H2O + N(1)-acetylspermidine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68689", "l": "3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate) => 3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015100", "l": "vanadium ion transmembrane transporter activity", "d": ["Enables the transfer of vanadium (V) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20252", "l": "L-alanine <=> D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678327", "l": "MIOX oxidises Ins to GlcA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050413", "l": "D-alanine 2-hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446364", "l": "Migfilin interacts with VASP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45775", "l": "[(1->4)-beta-D-mannosyl](n) + phosphate <=> [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60663", "l": "1,4-benzoquinone + H(+) + NADH <=> hydroquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75624", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate => 14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611851", "l": "ADRB2 bind ADR,NAd (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195378", "l": "Homodimerization of VEGF proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67778", "l": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate => a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74340", "l": "O-3-methylbutanoyl-(R)-carnitine(in) => O-3-methylbutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9823906", "l": "TBK1 is phosphorylated within the activated TLR4 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57605", "l": "a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:1990599", "l": "3' overhang single-stranded DNA endodeoxyribonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within 3' overhang single-stranded deoxyribonucleic acid by creating internal breaks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13461", "l": "3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2 = 2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16892", "l": "2-oxoglutarate + 6-acetamido-3-aminohexanoate <=> 6-acetamido-3-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840807", "l": "OPTN binds ATG9A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912790", "l": "CBL binds CRK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63916", "l": "5-fluorouridine + ATP = 5-fluorouridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50465", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH => 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.197202967246071", "identifiers": [{"i": "GO:0042562", "l": "hormone binding", "d": ["Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70874", "l": "L-glutamine(in) + L-valine(out) + Na(+)(out) <=> L-glutamine(out) + L-valine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59416", "l": "H2O + O2 + tryptamine = H2O2 + indole-3-acetaldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102398", "l": "dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose = S-adenosyl-L-homocysteine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73897", "l": "ADP + gamma-L-glutamylspermine + H(+) + phosphate => ATP + L-glutamate + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167083", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74261", "l": "H(+) + L-homoserine + tRNA(Lys) => H2O + L-homoseryl-tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77218", "l": "dATP + H2O <=> 2-deoxyribose 5-triphosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665998", "l": "MKL1 binds SRF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30116", "l": "decanoyl-[ACP] + H2O => decanoate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.28", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430135", "l": "p-SLP-76 binds ADAP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55278", "l": "9-cis-retinyl tetradecanoate + CoA => 9-cis-retinol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50678", "l": "N-terminal L-aspartyl-[protein] + NH4(+) => H(+) + H2O + N-terminal L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36484", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA => (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40017", "l": "13-epi-manool + diphosphate => (+)-copalyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8960973", "l": "RLBP1:11cRAL dissociates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28600", "l": "acetate + L-lysine => H2O + N-acetyl-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061463", "l": "O-acetyl-ADP-ribose deacetylase activity", "d": ["Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49349", "l": "2,2-dihydroxyspirilloxanthin => 2-oxospirilloxanthin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49582", "l": "cyclic pyranopterin phosphate + diphosphate => (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32015", "l": "(2E,6E)-farnesyl diphosphate = (-)-delta-cadinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.97", "l": "\"(-)-delta-cadinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692376", "l": "BCL2 binds BCL2 antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35589", "l": "phosphate + riboflavin => FMN + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30657", "l": "ADP + dUDP => ATP + dUMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850961", "l": "PREX2 binds PTEN and inhibits it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25972", "l": "H2O + N(8)-acetylspermidine + O2 = 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48938", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein] => 2-oxoglutarate + L-prolyl-[Skp1 protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873919", "l": "Phosphorylation of JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209134", "l": "Phosphorylation of ARM by CKIalpha (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029473", "l": "Branching and elongation of mother and daughter filaments (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64898", "l": "2 H(+) + 2 phosphate + UMP => 2 H2O + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634669", "l": "IMPACT binds GCN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38064", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA => 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34732", "l": "15-methylhexadecasphing-4-enine + a fatty acyl-CoA => CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404200", "l": "IGF1,2 binds IGF1R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53790", "l": "allodeoxycholate + beta-muricholoyl-CoA => allodeoxycholoyl-CoA + beta-muricholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73757", "l": "Binding of RRN3 to RNA Polymerase I (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033773", "l": "isoflavone 2'-hydroxylase activity", "d": ["Catalysis of the reaction: an isoflavone + O2 + reduced [NADPH-hemoprotein reductase] = a 2'-hydroxyisoflavone + H+ + H2O + oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16234", "l": "(R)-pantoate + NADP(+) => 2-dehydropantoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18305", "l": "acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-4-O-acetylneuraminate", "d": [], "t": []}, {"i": "EC:2.3.1.44", "l": "\"N-acetylneuraminate 4-O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530565", "l": "iC3b proteolysis (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446212", "l": "Flipping of the N-glycan precursor to inside the ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801675", "l": "PLK2 phosphorylates NPM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24419", "l": "2,4'-dihydroxyacetophenone + O2 <=> 4-hydroxybenzoate + formate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018758", "l": "RHOH binds effectors at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70654", "l": "(9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein] <=> H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75850", "l": "Addition of the third nucleotide on the nascent transcript (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56736", "l": "H2O + O2 + retinal = H(+) + H2O2 + retinoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38801", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68352", "l": "pppA(2'-5')pG = 3',2'-cGAMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004603", "l": "phenylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191072", "l": "Synthesis of Cx43 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47249", "l": "2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone => 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19300", "l": "ATP + beta-alanine + L-histidine <=> ADP + carnosine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023845", "l": "ESR1:ESTG binds to proximal and distal regions of the CTSD promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443418", "l": "GP1b signaling involves c-Src (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72385", "l": "Na(+)(in) + urate(out) => Na(+)(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59548", "l": "N,N',N''-triacetylchitotriose + O2 = H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39675", "l": "(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68543", "l": "(2Z,6Z)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50047", "l": "an acyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22697", "l": "AH2 + androst-4-ene-3,17-dione + O2 => A + H2O + testololactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37002", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48343", "l": "a medium chain fatty acid + ATP + CoA <=> a medium-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41096", "l": "H2O + sphing-4-enine-phosphocholine => H(+) + phosphocholine + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75850", "l": "Addition of the third nucleotide on the nascent transcript (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71241", "l": "2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+) => 2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47146", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13743", "l": "indole-3-pyruvate + L-phenylalanine => 3-phenylpyruvate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50494", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64715", "l": "1-propanol + NADP(+) <=> H(+) + NADPH + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77250", "l": "H2O + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] <=> L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12459", "l": "CTP + D-ribitol 5-phosphate + H(+) <=> CDP-L-ribitol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58953", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose => (20S)-ginsenoside Rh1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848338", "l": "PNPLA4 hydrolyzes TAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001626", "l": "nociceptin receptor activity", "d": ["Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13309", "l": "H2O + NAD(+) + vanillin = 2 H(+) + NADH + vanillate", "d": [], "t": []}, {"i": "EC:1.2.1.67", "l": "\"vanillin dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047806", "l": "cytochrome-c3 hydrogenase activity", "d": ["Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72794", "l": "(4E,15E)-bilirubin IXalpha C8-beta-D-glucuronoside(out) <=> (4E,15E)-bilirubin IXalpha C8-beta-D-glucuronoside(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48631", "l": "a ribonucleotide in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70971", "l": "ACO2 isomerizes citrate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75198", "l": "2-dehydro-3-deoxy-D-arabinonate + NAD(+) <=> 5-hydroxy-2,4-dioxopentanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031688", "l": "A2B adenosine receptor binding", "d": ["Binding to an A2B adenosine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380241", "l": "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33690", "l": "3'-N-debenzoyltaxol + benzoyl-CoA <=> CoA + H(+) + taxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78682", "l": "Sr(2+)(in) <=> Sr(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050301", "l": "streptomycin-6-phosphatase activity", "d": ["Catalysis of the reaction: H2O + streptomycin 6-phosphate = phosphate + streptomycin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16267", "l": "5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46562", "l": "5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008970", "l": "phospholipase A1 activity", "d": ["Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009558", "l": "IL34 dimer binds SDC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63154", "l": "a fatty acid + taurine => an N-fatty acyl-taurine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70452", "l": "2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2 => a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42244", "l": "H(+) + malonyl-[ACP] + propanoyl-CoA = 3-oxopentanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033463", "l": "GGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GGA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21198", "l": "L-methionine + tetrahydropteroyltri-L-glutamate => 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.923250621671642", "identifiers": [{"i": "GO:0008409", "l": "5'-3' exonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22887", "l": "glyoxylate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42197", "l": "(9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676268", "l": "Formation of the MLL4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029270", "l": "Recruitment of PLCgamma to membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749977", "l": "UGT1A6 glucuronates ST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987214", "l": "p-STAT3 dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15622", "l": "an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156678", "l": "Activation of Cdc25C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48024", "l": "1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140822", "l": "NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the glutamate-35 residue of the N-terminal tail of histone H2B (or an equivalent residue)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19852", "l": "H2O + NADP(+) <=> ADP-D-ribose 2'-phosphate + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34688", "l": "AH2 + N-acyl-15-methylhexadecasphinganine + O2 => A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-398184", "l": "LARG activation by G alpha 12/13 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56471", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 <=> (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636461", "l": "PtpA binds Ubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77577", "l": "1-O-hexadecyl-3-(9Z)-octadecenoylglycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-hexadecylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399939", "l": "Autophosphorylation of PAK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.17", "l": "\"[phosphorylase] phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388560", "l": "EDNRA,EDNRB bind EDNs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14827", "l": "(S)-carvone + H(+) + NADH => (1R,5S)-carveol + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14003", "l": "CoA + glycocholate + H(+) => choloyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061788", "l": "EGF repeat binding", "d": ["Binding to Epidermal Growth Factor (EGF) repeats."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391913", "l": "FPR2 binds FPR2 ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668978", "l": "MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798082", "l": "TP53 family members bind the CASP1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55981", "l": "a 1,2-saturated acyl-CoA + an acyl-CoA + H2O => an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018768", "l": "RHOU auto-activates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28088", "l": "2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate => 2 H2O2 + Reactive Blue 5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102482", "l": "5-deoxy-D-glucuronate isomerase activity", "d": ["Catalysis of the reaction: 5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55168", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35197", "l": "L-quinate(out) => L-quinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48871", "l": "H2O + NADH <=> AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69074", "l": "Formation of Processive Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16103", "l": "n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+) => n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017797", "l": "NOTCH3 binds YBX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28096", "l": "di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate => di-trans,octa-cis-undecaprenyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362522", "l": "ALDHs oxidise atRAL to atRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73137", "l": "4',7-dihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 4',7,8-trihydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68610", "l": "3-hydroxyindolin-2-one + NADP(+) => H(+) + isatin + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785898", "l": "IL4R binds JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49450", "l": "alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose => beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607058", "l": "Activated protein C:PROCR binds F2R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48288", "l": "a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11376", "l": "(19E)-geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.36", "l": "\"geissoschizine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68811", "l": "6-O-alpha-D-glucopyranosyl-D-fructose + H2O <=> alpha-D-glucose + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112434", "l": "Formation of DSIF complex  (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210886", "l": "NEUROG3-dependent synthesis of PAX4 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53818", "l": "L-cysteine + succinate => hydrogen sulfide + O-succinyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75440", "l": "eburicol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 14-demethyleburicol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69184", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.155", "l": "\"phosphoglycerol geranylfarnesyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015231", "l": "5-formyltetrahydrofolate transmembrane transporter activity", "d": ["Enables the transfer of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17332", "l": "(1R,2S,4R)-borneol + NAD(+) <=> (1R,4R)-camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59940", "l": "2-methyloctadecanoyl-CoA + H2O = 2-methyloctadecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390674", "l": "ADRB1 bind ADR,NAd (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68397", "l": "a percarboxylic acid + H2O => a carboxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10787", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47110", "l": "H2O + taurocholate => cholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051120", "l": "hepoxilin A3 synthase activity", "d": ["Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867613", "l": "PICALM binds R-SNAREs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39349", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+) => (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30721", "l": "2-methyl-3-oxobutanoyl-CoA + CoA => acetyl-CoA + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42878", "l": "H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9835009", "l": "PRKN binds p-S-Ub:MOM proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67212", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2 = (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21309", "l": "(S)-2,3-epoxysqualene => cycloartenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61494", "l": "an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+) => a sphingoid base + an ultra-long-chain fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391936", "l": "EP1 receptor can bind PGE2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196417", "l": "Reduction of desmosterol to cholesterol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53224", "l": "16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176318", "l": "Loading of claspin onto DNA during replication origin firing (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-447226", "l": "Interleukin-12 binds Interleukin-12 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28445", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + dodecanoyl-[ACP] <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30379", "l": "(2E,6E)-farnesyl diphosphate = (+)-beta-chamigrene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.78", "l": "\"beta-chamigrene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1370500", "l": "PRLR binds SCF beta-TrCP complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56454", "l": "12-epi-hapalindole U => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18574", "l": "dihydrochelirubine + H(+) + O2 => chelirubine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-166817", "l": "Cleavage of C3 by C3 convertases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0099530", "l": "G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential", "d": ["A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937177", "l": "AHR:TCDD binds ARNT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174493", "l": "Glycosylation of ENV polyprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4647593", "l": "EP400 binds CDKN1A promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39148", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64377", "l": "8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid => a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005278", "l": "acetylcholine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58863", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955844", "l": "RBKS phosphorylates ribose to R5P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45234", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) => a (2E,4Z)-dienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836702", "l": "PKR inhibitors bind PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62500", "l": "holo-[peptidyl-carrier protein] + L-arginyl-AMP = AMP + H(+) + L-arginyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47892", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632738", "l": "DDIT4 binds 14-3-3 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40624", "l": "H2O + tritetradecanoylglycerol => 2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823706", "l": "VWF variant does not bind GPIb:IX:V (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850945", "l": "Casein kinase II phosphorylates PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177922", "l": "EGFR dimerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158849", "l": "Phenol can form a sulfate conjugate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43599", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 <=> 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73257", "l": "(2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine => (2S)-sakuranetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357472", "l": "PAK1-3 autophosphorylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340226", "l": "CYGB dioxygenates NO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42165", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 => (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74742", "l": "Phosphorylation of SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50732", "l": "4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] = (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41465", "l": "ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9620103", "l": "ALDH2 transforms GTN to NO (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72312", "l": "glutathione(in) + taurocholate(out) => glutathione(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482772", "l": "Release of platelet cytosolic components (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62090", "l": "2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH => D-glucosamine 6-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4411383", "l": "NLK phosphorylates TCF/LEF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40676", "l": "L-threonine => 2-aminobut-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696465", "l": "USP45 deubiquitinates ERCC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73041", "l": "H(+)(in) + Ni(2+)(in) => H(+)(out) + Ni(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15453", "l": "S-adenosyl-L-methionine + sarcosine = H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75231", "l": "H2O + L-galactono-1,4-lactone = H(+) + L-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72391", "l": "2 hydrogencarbonate(out) + oxalate(in) = 2 hydrogencarbonate(in) + oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47589", "l": "a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GQ1c (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48226", "l": "a neolactoside nLc4Cer(d18:1(4E)) + L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52771", "l": "2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O <=> 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13474", "l": "H2O + L-tryptophan + NAD(+) => H(+) + indole-3-pyruvate + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49589", "l": "L-erythrulose 1-phosphate => D-erythrulose 4-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55802", "l": "an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24761", "l": "H(+) + L-dopa + NADH => 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560802", "l": "Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32367", "l": "4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone = 4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate", "d": [], "t": []}, {"i": "EC:1.3.2.3", "l": "\"L-galactonolactone dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23191", "l": "NAD(+) + propane-1,3-diol <=> 3-hydroxypropanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57498", "l": "2-methyl-cis-aconitate + H2O => 2-methylcitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419049", "l": "ROCK activation by RHO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75049", "l": "N(omega),N(omega)-dimethyl-L-arginine(in) => N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.85", "l": "\"limulus clotting factor B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72816", "l": "L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) => L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57011", "l": "5,5'-dehydrodivanillate + H(+) + NADH + O2 <=> 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29070", "l": "formate + H(+) + menaquinone-8 <=> CO2 + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15270", "l": "L-xylo-hex-3-ulonolactone => H(+) + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46256", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.244991688848543", "identifiers": [{"i": "GO:0018455", "l": "alcohol dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73224", "l": "(3S)-citramalate(in) + sulfate(out) => (3S)-citramalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.368900840266221", "identifiers": [{"i": "GO:0033764", "l": "steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative."], "t": []}, {"i": "REACT:R-HSA-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58498", "l": "glycolaldehyde + H2O + NAD(+) + trimethylamine => choline + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850777", "l": "SPINK6 binds KLK14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18002", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030144", "l": "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712081", "l": "ALK fusions bind FRS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10653", "l": "a long-chain fatty aldehyde + H2O + NAD(+) => a long-chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432054", "l": "Aquaporin-1 passively transports water out of cell (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63446", "l": "GMP + H(+) + oxidized coenzyme F420-0 => (2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74378", "l": "H2O2(out) <=> H2O2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70860", "l": "L-asparagine(in) + L-glutamine(out) + Na(+)(out) => L-asparagine(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53792", "l": "benzylthiol + O2 = benzothialdehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42145", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22638", "l": "dCMP + diphosphate + H(+) => dCTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34049", "l": "6'''-deamino-6'''-oxoneomycin C + H2O2 => 6'''-deamino-6'''-hydroxyneomycin C + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061953", "l": "mRNA (adenine-N1-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine in mRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56068", "l": "an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000249", "l": "C-22 sterol desaturase activity", "d": ["Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77056", "l": "cyclopentylamine + H2O + NADP(+) => cyclopentanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36176", "l": "1-O-alkylglycerone 3-phosphate + H(+) + NADPH => 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10974", "l": "alpha-D-hexose 1-phosphate + NH4(+) => a D-hexose + H(+) + phosphoramidate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15800", "l": "(4Z,15Z)-bilirubin IXalpha + NAD(+) <=> biliverdin IXalpha + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53960", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2 = 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.13", "l": "\"4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50506", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein] => acetyl-CoA + N-terminal L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681840", "l": "RTC synthesizes SARS-CoV-1 plus strand genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53287", "l": "NAD(+) + scyllo-inosose <=> 3-dehydro-scyllo-inosose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52228", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + biliverdin IXbeta + CO + Fe(2+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37327", "l": "ATP + H2O + L-methionyl-L-alanine(out) = ADP + H(+) + L-methionyl-L-alanine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759186", "l": "AcK-NFE2L2- dependent NQO1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48443", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol <=> a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727607", "l": "MME:Zn2+ binds sacubitrilat (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001066", "l": "amylopectin binding", "d": ["Binding to amylopectin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199910", "l": "MSK1 activates ATF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73053", "l": "hydrogencarbonate(out) + taurocholate(in) => hydrogencarbonate(in) + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840949", "l": "ARSA removes sulfate from SM3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008964", "l": "phosphoenolpyruvate carboxylase activity", "d": ["Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229343", "l": "AXIN is phosphorylated in the destruction complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23988", "l": "(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.83", "l": "\"LL-diaminopimelate aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53216", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052878", "l": "linoleate 8R-lipoxygenase activity", "d": ["Catalysis of the reaction: O2 + linoleate = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30941", "l": "ADP + dITP => ATP + dIDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50898", "l": "(8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate => 8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19726", "l": "H(+) + UDP-alpha-D-galacturonate => CO2 + UDP-beta-L-arabinopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429860", "l": "DCP1-DCP2 complex decaps mRNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67977", "l": "all-trans-neurosporene => beta-zeacarotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24679", "l": "5,6,7,8-tetrahydromethanopterin + formaldehyde => 5,10-methylenetetrahydromethanopterin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033402", "l": "UUC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731924", "l": "EDNRA binds EDNs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72242", "l": "estrone 3-sulfate(out) + L-glutamate(in) <=> estrone 3-sulfate(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56300", "l": "[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] = [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67570", "l": "adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate => 3'-phosphoadenylyl sulfate + taurochenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112037", "l": "Inactivation of PLC beta (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20614", "l": "3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine => adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858270", "l": "HILPDA binds lipid droplets (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1364044", "l": "PRLR:JAK2 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0003843", "l": "1,3-beta-D-glucan synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211948", "l": "CYP3A4 can N-demethylate loperamide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168888", "l": "Alpha1-Microglobulin binds heme (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45901", "l": "a (3Z)-enoyl-CoA => a 4-saturated (2E)-enoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.5", "l": "\"peptidyl-dipeptidase Dcp\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15802", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32576", "l": "(2E)-geranyl diphosphate => (1R,5R)-alpha-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15076", "l": "3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O <=> D-glucuronate + N(2),6-disulfo-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26308", "l": "2-aminophenol + O2 <=> 2-aminomuconate 6-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.550087943541328", "identifiers": [{"i": "GO:0031406", "l": "carboxylic acid binding", "d": ["Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618486", "l": "miR-26 binds to the 3'UTR of the ABCA1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58793", "l": "ATP + Fe(III)-petrobactin(out) + H2O => ADP + Fe(III)-petrobactin(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.81", "l": "\"(+)-pulegone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41582", "l": "5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate => 5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928646", "l": "EPHAs bind EFNAs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65134", "l": "CO2 + H2O + preaustinoid A2 + succinate => 2-oxoglutarate + O2 + preaustinoid A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49507", "l": "phosphinomethylmalate <=> phosphinomethylisomalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77098", "l": "5-S-cysteinyldopa + L-dopaquinone <=> 5-S-cysteinyldopaquinone + L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.112", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54811", "l": "H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 <=> H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68904", "l": "3-phenylpropanoate + ATP + H(+) + NADPH = 3-phenylpropanal + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51961", "l": "(Z)-2-methylpropanal oxime => 2-methylpropanenitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391372", "l": "GNRHR binds GNRH1,2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30504", "l": "H2O + N-acetyl-L-glutamate 5-semialdehyde => acetate + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29659", "l": "O-acetyl-L-serine(in) = O-acetyl-L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30965", "l": "7,7',9,9'-tetra-cis-lycopene + a quinol => 7,9,9'-tri-cis-neurosporene + a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61290", "l": "5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+) => 5-deoxy-D-ribose + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36215", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73675", "l": "ADP(out) + dAMP(in) + H(+)(out) = ADP(in) + dAMP(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29161", "l": "3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out) => 3 a menaquinol(in) + 2 H(+)(out) + nitrite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61388", "l": "ATP + biotin(in) + H2O = ADP + biotin(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51585", "l": "4-(trimethylamino)butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73515", "l": "UDP(out) + UTP(in) = UDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34846", "l": "7,8-dihydromonapterin 3'-triphosphate + 3 H2O <=> 7,8-dihydromonapterin + 2 H(+) + 3 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018505", "l": "cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018603", "l": "nitrobenzene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + nitrite + catechol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35467", "l": "(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)", "d": [], "t": []}, {"i": "EC:2.1.1.269", "l": "\"dimethylsulfoniopropionate demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804100", "l": "HMGB1 binds LPS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59038", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67271", "l": "(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate <=> sch 210972", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73547", "l": "GTP(out) + UTP(in) = GTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687585", "l": "Defective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73235", "l": "2,6-dichlorobenzoquinone + H2O = 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18790", "l": "D-glucosamine 6-phosphate => D-galactosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11171", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) <=> 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451418", "l": "Pellino ubiquitinates IRAK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203700", "l": "eNOS translocation from Golgi to Caveolae (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55669", "l": "11-cis-retinol--[retinol-binding protein] + NAD(+) => 11-cis-retinal--[retinol-binding protein] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825790", "l": "p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0061922", "l": "histone propionyltransferase activity", "d": ["Catalysis of the reaction: propionyl-CoA + histone = CoA + propionyl-histone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918225", "l": "TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112395", "l": "Abortive termination of elongation after arrest (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46104", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = corticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48563", "l": "H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate <=> D-ribose 5-phosphate + N(6)-dimethylallyladenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098750", "l": "FYXD domain binding", "d": ["Binding to a FXYD domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507875", "l": "Aquaporins passively transport urea into cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428260", "l": "DEGS2 oxygenates dihydroceramide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389352", "l": "Translocation of Vav1 to CD28 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28819", "l": "5-dehydro-D-gluconate(in) + H(+)(in) = 5-dehydro-D-gluconate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65949", "l": "a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 => A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043955", "l": "3-hydroxypropionyl-CoA synthetase activity", "d": ["Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733323", "l": "Src family kinases phosphorylate CBL in CSF1 dimer:p-Y561-CSF1R dimer:CBL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36626", "l": "3-phenylpyruvate + S-adenosyl-L-methionine <=> (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63838", "l": "(2R)-2-hydroperoxyhexadecanoate => hexadecanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30910", "l": "(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) <=> 2-methylbutanoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37389", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696670", "l": "CHD1L is recruited to GG-NER site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24311", "l": "25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013023", "l": "RHOB GEFs activate RHOB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44655", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097748", "l": "3'-5' RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 5'-end."], "t": []}, {"i": "RHEA:57528", "l": "a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O = a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047681", "l": "aryl-alcohol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40455", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA = (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9818574", "l": "TASP1 cleaves KMT2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001596", "l": "angiotensin type I receptor activity", "d": ["An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032770", "l": "Translocation of YAP1 to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174587", "l": "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863727", "l": "STON2 is neddylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41456", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112429", "l": "Formation of FACT complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57292", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O = a guanosine in RNA + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047837", "l": "D-xylose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-xylose + NADP+ = D-xylono-1,5-lactone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55269", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate => (R)-glycerate + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34696", "l": "(2E,6E)-farnesyl diphosphate => Delta(6)-protoilludene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48934", "l": "a ganglioside GQ1b + CMP + H(+) => a ganglioside GT1b + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981622", "l": "Myoglobin:oxygen dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76521", "l": "(R)-lipoate + L-lysyl-[lipoyl-carrier protein] => H2O + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690023", "l": "NUBPL binds 4Fe-4S (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419645", "l": "Dimerization of LIMK1 by Hsp90 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22288", "l": "an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.123", "l": "\"endoglycosylceramidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54743", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.2", "l": "\"4-hydroxybenzoate 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61938", "l": "ADP + cycloheximide(out) + H(+) + phosphate => ATP + cycloheximide(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63870", "l": "(2R,9Z)-2-hydroperoxyoctadecenoate => (9Z)-octadecenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25400", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981353", "l": "RASA1 stimulates RAS GTPase activity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71693", "l": "glycyl-L-glutamate(in) + 2 H(+)(in) => glycyl-L-glutamate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617446", "l": "HOXD1 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17728", "l": "(2S,3S)-2-methylcitrate <=> 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74844", "l": "3'-phosphoadenylyl sulfate + a ganglioside GM1b => adenosine 3',5'-bisphosphate + an 8-O-sulfo-ganglioside GM1b + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30507", "l": "2-demethylmenaquinone-8 + H(+) + NADH = 2-demethylmenaquinol-8 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69126", "l": "glycine + indole-3-pyruvate => glyoxylate + L-tryptophan", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30292", "l": "(9Z,12Z)-octadecadienoate + O2 => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12880", "l": "acetylacetone + O2 <=> acetate + H(+) + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944220", "l": "Association of procollagen type XXIII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19411", "l": "3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH => cholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51688", "l": "galactitol + NAD(+) = H(+) + keto-L-tagatose + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.406", "l": "\"galactitol 2-dehydrogenase (L-tagatose-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19628", "l": "L-threonine <=> acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013006", "l": "RHOA:GTP translocates to the ER membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67757", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50220", "l": "(S)-demethyl-4-deoxygadusol = (R)-demethyl-4-deoxygadusol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990254", "l": "keratin filament binding", "d": ["Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047478", "l": "aspartate-ammonia ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: L-aspartate + ATP + NH4 = L-asparagine + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102739", "l": "(gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A36 + O2 + 2-oxoglutarate = H+ + gibberellin A4 + succinate + 2 carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16109", "l": "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.11", "l": "\"6-phosphofructokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52185", "l": "(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73504", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine => 3',4,7-trihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162188", "l": "COQ5 methylates MDMQ10H2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30829", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052900", "l": "spermine oxidase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermine = 1,3-diaminopropane + H2O2 + N-(3-aminopropyl)-4-aminobutanal."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050410", "l": "3-oxolaurate decarboxylase activity", "d": ["Catalysis of the reaction: 3-oxolaurate + H+ = 2-undecanone + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944216", "l": "Association of procollagen type XV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218806", "l": "FYN autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804100", "l": "HMGB1 binds LPS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204364", "l": "ROBO1 binds SLIT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34428", "l": "(-)-lariciresinol + NADP(+) => (-)-pinoresinol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45469", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate => (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418172", "l": "F2R binds ARRB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35105", "l": "fusidate(out) => fusidate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377644", "l": "Release of CSK from SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40068", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O => 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16901", "l": "acetyl-CoA + L-2,4-diaminobutanoate = (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.178", "l": "\"diaminobutyrate acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9825704", "l": "AKT3 phosphorylates TBX3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202721", "l": "JAM2 binds JAM3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18637", "l": "H2 + NADP(+) = H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53863", "l": "7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) <=> dehydrocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57714", "l": "4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP => (E)-sinapaldehyde + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30569", "l": "5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate => 5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.69", "l": "\"5-hydroxyfuranocoumarin 5-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30666", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> hapalindole H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55746", "l": "coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n) => coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399930", "l": "Activation of PAK by Rac1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5627072", "l": "RHOQ binds GOPC:CFTR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786650", "l": "DDHD1,2 hydrolyse PA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12310", "l": "2 H(+) + L-2-aminoadipate + NADH => (S)-2-amino-6-oxohexanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102734", "l": "brassinolide synthase activity", "d": ["Catalysis of the reaction: H+ + castasterone + NADPH + O2 = brassinolide + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77040", "l": "4-hydroxyhexan-3-amine + H2O + NAD(+) => 4-hydroxyhexan-3-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57260", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP = GDP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380949", "l": "AMPK is dephosphorylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21258", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate => 3-phosphoshikimate + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.244991688848543", "identifiers": [{"i": "GO:0003964", "l": "RNA-directed DNA polymerase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047271", "l": "glycosaminoglycan galactosyltransferase activity", "d": ["Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018478", "l": "malonate-semialdehyde dehydrogenase (acetylating) activity", "d": ["Catalysis of the reaction: 3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430308", "l": "PARVB interacts with Alpha-actinin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73704", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-glucosamine(in) => UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-glucosamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.3", "l": "\"plus-end-directed kinesin ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106219", "l": "zinc ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of zinc."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5339535", "l": "CPTP transports C1P from plasma membrane to Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73360", "l": "ATP + beta-alanine + dopamine => AMP + beta-alanyl-dopamine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334152", "l": "DNMT3A:DNMT3L methylates cytosine in DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909729", "l": "Activation of JAK kinases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034617", "l": "tetrahydrobiopterin binding", "d": ["Binding to a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54927", "l": "(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38303", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.29", "l": "\"D-glucosaminate-6-phosphate ammonia lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432010", "l": "Aquaporin-1 passively transports water into cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9676268", "l": "Formation of the MLL4 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58397", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15649", "l": "carbamate + 2 H(+) = CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418856", "l": "Activation of Rac1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25300", "l": "acetate + 2 H(+) + NADPH => acetaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24611", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) <=> 2,5-dioxopentanoate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202394", "l": "Translocation of CARMA1 to Plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29403", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 = 3-demethylubiquinol-8 + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0045142", "l": "triplex DNA binding", "d": ["Binding to a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19977", "l": "3'-phosphoadenylyl sulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate", "d": [], "t": []}, {"i": "EC:2.8.2.9", "l": "\"tyrosine-ester sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45374", "l": "(9Z)-octadecenoate + sphinganine => H2O + N-(9Z-octadecenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30984", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75953", "l": "CO2 + formaldehyde + neomorphinone + succinate => 2-oxoglutarate + O2 + oripavine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15652", "l": "carbamate + 2 H(+) <=> CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32434", "l": "(1R,4S)-menthone + H(+) + NADPH + O2 <=> (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46532", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.16", "l": "\"linoleoyl-lipid Delta(12) conjugase (11E,13Z-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31478", "l": "soyasapogenol B + UDP-alpha-D-glucuronate <=> H(+) + soyasapogenol B 3-O-beta-D-glucuronate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58601", "l": "2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30778", "l": "H2O + O2 + pyridoxamine <=> H2O2 + NH4(+) + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036424", "l": "L-phosphoserine phosphatase activity", "d": ["Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.3.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788628", "l": "p-Y-STATs dissociate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047665", "l": "aminolevulinate transaminase activity", "d": ["Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047506", "l": "(deoxy)adenylate kinase activity", "d": ["Catalysis of the reaction: ATP + dAMP = ADP + dADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77081", "l": "Formation of the CE:GMP intermediate complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47663", "l": "acetyl-CoA + L-methionine sulfoximine <=> CoA + H(+) + N-acetyl-L-methionine sulfoximine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27343", "l": "A + H(+) + H2O + hydroxylamine => AH2 + NH4(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54414", "l": "a 3-oxo-Delta(4)-steroid + H(+) + NADPH => a 3-oxo-5beta-steroid + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68582", "l": "ADP + H(+) + L-kynurenine(in) + phosphate => ATP + H2O + L-kynurenine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28469", "l": "pyridoxamine(in) <=> pyridoxamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654224", "l": "Activated FGFR3 binds PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11152", "l": "5-pyridoxate + NADPH + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.241", "l": "\"5-pyridoxate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.146", "l": "\"(iso)eugenol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9853499", "l": "DLD dimer dehydrogenates dihydrolipoyl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994148", "l": "LRRC16A binds F-actin capping protein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391377", "l": "Luteinizing hormone receptor can bind LH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46821", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21623", "l": "FMNH2 + NAD(+) <=> FMN + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72375", "l": "hydrogencarbonate(out) + iodide(in) = hydrogencarbonate(in) + iodide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696482", "l": "CTF1 binds LIFR:JAKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630055", "l": "NTHL1 D239Y does not cleave dihydrouracil (DHU) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987223", "l": "IL10RB binds TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561072", "l": "OCT3 mediates renal uptake of organic cations (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49753", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate => CO2 + 2 H2O + NAD(+) + proviolacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62315", "l": "salicylate + UDP-alpha-D-glucose <=> H(+) + salicylate 2-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21575", "l": "3-hydroxy-2-methyl-1H-quinolin-4-one + O2 <=> CO + H(+) + N-acetylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77928", "l": "H2O + N-(4-aminobutylpyrrolinium) ion + O2 => H2O2 + N-(4-oxobutylpyrrolinium) ion + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374663", "l": "DCC interaction with Ezrin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75891", "l": "Abortive Initiation After Second Transition (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50692", "l": "ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate = ADP + alpha-maltose 1-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.342", "l": "\"alpha-maltose-1-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54633", "l": "2-oxoglutarate + O2 + tetradecanoyl-CoA => 2-hydroxytetradecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64232", "l": "8 H(+) + holo-[ACP] + 8 malonyl-CoA = atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51168", "l": "(R)-adrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58260", "l": "H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] = ADP-D-ribose + L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10140", "l": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin D2", "d": [], "t": []}, {"i": "EC:1.1.1.188", "l": "\"prostaglandin-F synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013435", "l": "RHOD auto-activates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19879", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49597", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose => H(+) + N-acyl-D-galactosylsphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48844", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57951", "l": "2-hydroxytoluene + H(+) + NADH + O2 <=> 3-methylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050513", "l": "glycoprotein 2-beta-D-xylosyltransferase activity", "d": ["Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + UDP-alpha-D-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53149", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59680", "l": "D-maltopentaose + O2 = D-maltopentaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15591", "l": "4-hydroxyphenylglyoxylate + L-glutamate => 2-oxoglutarate + D-4-hydroxyphenylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70305", "l": "cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine => beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27423", "l": "(3E,6E)-alpha-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611277", "l": "P2RY12 binds P2RY12 antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68987", "l": "a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine <=> a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29880", "l": "ATP + H2O + L-arginine(out) => ADP + H(+) + L-arginine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250264", "l": "TXNIP binds reduced thioredoxin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54835", "l": "a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48141", "l": "2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050205", "l": "oxamate carbamoyltransferase activity", "d": ["Catalysis of the reaction: carbamoyl phosphate + oxamate = oxalurate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013006", "l": "RHOA:GTP translocates to the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700193", "l": "ALK mutants phosphorylate SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16499", "l": "H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine => adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9861640", "l": "CTLH E3 ligase ubiquitinates PKM-1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047091", "l": "L-lysine 6-monooxygenase (NADPH) activity", "d": ["Catalysis of the reaction: L-lysine + NADPH + O2 = N(6)-hydroxy-L-lysine + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427570", "l": "Group 3 - Selective Cl- transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12368", "l": "2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH2", "d": [], "t": []}, {"i": "EC:1.1.99.4", "l": "\"dehydrogluconate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58461", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine => a monoacyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9794444", "l": "ALB binds Cipro (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31261", "l": "3-butynoate + 2 H(+) + NADH => but-3-ynal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205231", "l": "Dimerization of KIT upon SCF binding (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470508", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68842", "l": "(6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0043208", "l": "glycosphingolipid binding", "d": ["Binding to glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549304", "l": "OCT3 mediates renal clearance of organic cations (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22312", "l": "5-(methylsulfanyl)-D-ribose + ATP = ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.100", "l": "\"S-methyl-5-thioribose kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16011", "l": "ADP + formyl phosphate => ATP + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22255", "l": "a globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a globoside Gb4Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211983", "l": "CYP2J2 oxidises ARA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69179", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] <=> 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46722", "l": "(2E)-hexenoyl-CoA + H2O => (3R)-hydroxyhexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37820", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665998", "l": "MKL1 binds SRF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44859", "l": "(9Z)-octadecenoyl-CoA + (R)-carnitine <=> CoA + O-(9Z)-octadecenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63305", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68288", "l": "heptanoyl-CoA + L-seryl-[protein] = CoA + O-heptanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13776", "l": "(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57145", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine => 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52908", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + O2 = 3-dimethylallyl-4-hydroxymandelate + CO2", "d": [], "t": []}, {"i": "EC:1.13.11.83", "l": "\"4-hydroxy-3-prenylphenylpyruvate oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28457", "l": "N(6)-(D-fructosyl)-L-lysine(in) <=> N(6)-(D-fructosyl)-L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58101", "l": "1-(15Z-tetracosenoyl)-glycerol + H2O => (15Z)-tetracosenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28194", "l": "(2S)-3-sulfolactate + NAD(+) = 3-sulfopyruvate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.310", "l": "\"(S)-sulfolactate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46266", "l": "a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47965", "l": "H2O + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14258", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29617", "l": "alpha-maltotetraose + beta-D-glucose => alpha-maltotriose + beta-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683888", "l": "LMCD1 binds GATA6, sequestering it (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183058", "l": "Expression of Adiponectin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705584", "l": "HMGCR dimer binds statins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004156", "l": "dihydropteroate synthase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62435", "l": "a uridine in tRNA + S-adenosyl-L-methionine <=> a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11812", "l": "H2O + methanethiol + O2 = formaldehyde + H(+) + H2O2 + hydrogen sulfide", "d": [], "t": []}, {"i": "EC:1.8.3.4", "l": "\"methanethiol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43038", "l": "2-aminoprop-2-enoate + H(+) + hydrogen sulfide => L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35107", "l": "3-nitrotyramine + H2O + O2 = 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66782", "l": "N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate => 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944254", "l": "Association of procollagen type XXVI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013157", "l": "CDC42 binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10109", "l": "(7S)-salutaridinol + NADP(+) => H(+) + NADPH + salutaridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28395", "l": "L-alanyl-L-glutamate => L-alanyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.3.1", "l": "\"nitroalkane oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102623", "l": "scutellarein 7-methyl ether 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine = cirsimaritin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0031763", "l": "galanin receptor binding", "d": ["Binding to a galanin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30417", "l": "formate + H2O + heptadecane + 2 NADP(+) => H(+) + 2 NADPH + O2 + octadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49194", "l": "1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630043", "l": "Defective NTHL1 truncation mutants do not bind thymine glycol (Tg) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662706", "l": "Dopachrome transforms to DHI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36238", "l": "1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0140776", "l": "protein-containing complex destabilizing activity", "d": ["A molecular function that involves direct binding to one of the subunits of a protein-containing complex and promoting the dissociation of one or many subunits. This often happens by changing the conformation of the protein being bound, which decreases its affinity for the rest of the complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42810", "l": "3 reduced coenzyme F420-(gamma-L-Glu)(n) + sulfite => 2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097256", "l": "phenyllactate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-3-phenyllactate + NAD+ = 3-phenylpyruvate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70890", "l": "L-glutamine(in) + L-serine(out) + Na(+)(out) <=> L-glutamine(out) + L-serine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51411", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69402", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP] => a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706344", "l": "FLT3 phosphorylates GRB10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134800", "l": "STING dimerization (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176956", "l": "Formation of GINS complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34438", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine <=> 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417896", "l": "P2Y6 receptor can bind to UDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11449", "l": "NAD(+) + pregnan-21-ol => H(+) + NADH + pregnan-21-al", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803403", "l": "PCBP4 binds the CDKN1A mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18887", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-beta-L-fucose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52061", "l": "12-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811479", "l": "ING2 recruits EP300 to TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870461", "l": "RABGGTA and RABGGTB bind (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218821", "l": "PDK1 phosphorylates PKC (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61534", "l": "ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11524", "l": "5beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452392", "l": "Transcription of POU5F1 (OCT4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001641", "l": "group II metabotropic glutamate receptor activity", "d": ["A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66157", "l": "butanoyl-CoA + tyramine => CoA + H(+) + N-butanoyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043716", "l": "2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938199", "l": "RUNX1:CBFB binds the MYL9 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008444", "l": "CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45016", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine = L-selenomethionine + tetrahydropteroyltri-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72881", "l": "NH4(+) + phosphonoacetaldehyde => (1R)-(2-amino-1-hydroxyethyl)phosphonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43496", "l": "L-gulonate + NAD(+) = H(+) + keto-D-fructuronate + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.380", "l": "\"L-gulonate 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32915", "l": "sn-glycero-3-phospho-1D-myo-inositol(out) = sn-glycero-3-phospho-1D-myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990856", "l": "methionyl-initiator methionine tRNA binding", "d": ["Binding to methionine-initiator methionine tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2203516", "l": "Alpha-1-Microglobulin is cleaved (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400143", "l": "Fatty acid ligands activate PPARA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54484", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350598", "l": "Arginine<=>Agmatine+CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76840", "l": "H2O + NAD(+) + propylamine => H(+) + NADH + NH4(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18889", "l": "D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.15", "l": "\"alpha,alpha-trehalose-phosphate synthase (UDP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40834", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78134", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol <=> a 1,3-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56098", "l": "[protein]-C-terminal Gly-Gly-AMP + diphosphate => [protein]-C-terminal Gly-Gly + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46231", "l": "apo-[peptidyl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34420", "l": "(+)-lariciresinol + NADP(+) => (+)-pinoresinol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034877", "l": "isonicotinate dehydrogenase activity", "d": ["Catalysis of the reaction: isonicotinate + acceptor + H2O = 2-hydroxyisonicotinate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36277", "l": "3-methylxanthine + formaldehyde + H2O + NADP(+) => H(+) + NADPH + O2 + theophylline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46241", "l": "a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814094", "l": "ARL1:GTP binds ARFIP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13807", "l": "a 3-oxo-Delta(4)-steroid + AH2 => A + a 3-oxo-5alpha-steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38942", "l": "dioscin + 2 H2O <=> diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67726", "l": "CMP(in) + CMP-N-acetyl-beta-neuraminate(out) => CMP(out) + CMP-N-acetyl-beta-neuraminate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43232", "l": "H2O + isatin = H(+) + isatinate", "d": [], "t": []}, {"i": "EC:3.5.2.20", "l": "\"isatin hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.43", "l": "\"classical-complement-pathway C3/C5 convertase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35441", "l": "archaetidylserine + CMP + H(+) => CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62186", "l": "diphosphate + labd-13(16),14-diene-9-ol => peregrinol diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664850", "l": "ATM binds PEX5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78224", "l": "D-allo-isoleucine + H2O + O2 => (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549428", "l": "Expression of FACTOR VII (F7) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21182", "l": "D-glucose + indole-3-acetyl-1D-myo-inositol => 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64144", "l": "H2O + N-(9Z-octadecenoyl)-L-methionine = (9Z)-octadecenoate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70395", "l": "3-oxosphinganine + docosanoyl-CoA = CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693243", "l": "RHOD translocates to the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2423785", "l": "CR:atREs binds apoE and HSPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22757", "l": "a long-chain primary fatty alcohol + O2 => a long-chain fatty aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59584", "l": "ATP + beta-alanine + L-lysine = ADP + beta-alanyl-L-lysine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72483", "l": "(S)-malate(in) + citrate(out) = (S)-malate(out) + citrate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682377", "l": "LC3 de-lipidation by ATG4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26046", "l": "acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-9-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74212", "l": "H2O + L-threonyl-tRNA(Lys) => L-threonine + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697920", "l": "CLOCK acetylates lysine-10 of histone H3, H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77093", "l": "AMP + diphosphate + H(+) + isochorismoyl-L-glutamate => ATP + isochorismate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803437", "l": "TP53 stimulates ZNF385A transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11838", "l": "CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine => CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11793", "l": "H(+) + NADH + O2 + propene => 1,2-epoxypropane + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55970", "l": "(+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine => (+)-kolavelool + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70482", "l": "H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74706", "l": "(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 5-dehydro-6-demethoxyfumagillol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202534", "l": "Ubiquitination of NEMO by TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24605", "l": "7-methylxanthine + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + theobromine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75955", "l": "2-oxoglutarate + O2 + thebaine = CO2 + formaldehyde + oripavine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22725", "l": "a sterol + UDP-alpha-D-glucose => a sterol 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23125", "l": "2 (2R)-3-phosphoglycerate + 2 H(+) => CO2 + D-ribulose 1,5-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20139", "l": "baccatin III + CoA => 10-deacetylbaccatin III + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016412", "l": "serine O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52104", "l": "a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43324", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20532", "l": "2-cis-(+)-abscisic aldehyde + H2O + O2 <=> 2-cis-(+)-abscisate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24151", "l": "D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466764", "l": "NRPE condenses with atRAL to form A2PE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050024", "l": "L-galactonolactone oxidase activity", "d": ["Catalysis of the reaction: L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2 + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23070", "l": "6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+) => 6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070181", "l": "small ribosomal subunit rRNA binding", "d": ["Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18070", "l": "L-arginine => D-arginine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981622", "l": "Myoglobin:oxygen dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614811", "l": "Transcriptional Activation of the HCMV Genome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627104", "l": "XIAP binds CASP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218821", "l": "PDK1 phosphorylates PKC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55886", "l": "[aequorin]--dioxetanone => [aequorin] + 3 Ca(2+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437932", "l": "p-Y348-SYK binds VAV family (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71173", "l": "GSTZ1 isomerizes 4-MAA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24485", "l": "NAD(+) + sulcatol => H(+) + NADH + sulcatone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661419", "l": "ALB binds extracellular heme (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18501", "l": "ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.71", "l": "\"Delta(24(24(1)))-sterol reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75383", "l": "bromide(in) = bromide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22210", "l": "H2O + homogentisate + NAD(+) => 3-hydroxyphenylacetate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694553", "l": "Recruitment of Spike trimer to assembling virion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32881", "l": "(1R,4R)-bornane-2,5-dione + H(+) + NADH => (1R,4R,5R)-5-hydroxycamphor + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28533", "l": "H2O + XMP <=> phosphate + xanthosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.51", "l": "\"cruzipain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821412", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57746", "l": "[protein]-dithiol + phylloquinone => [protein]-disulfide + phylloquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47512", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isocholate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983158", "l": "Trimming of peptides in ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44766", "l": "6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158399", "l": "kallikrein binds SERPING1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60113", "l": "(R)-3-(indol-3-yl)lactoyl-CoA => (E)-3-(indol-3-yl)acryloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57955", "l": "H(+) + NADH + O2 + phenol <=> catechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48955", "l": "14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) <=> 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37105", "l": "(N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008140", "l": "cAMP response element binding protein binding", "d": ["Binding to a cAMP response element binding protein (a CREB protein)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74096", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + an L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32558", "l": "(2E)-geranyl diphosphate + H2O <=> (R)-alpha-terpineol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58098", "l": "glycerol + H(+) + tetracosanoate => 1-tetracosanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874078", "l": "PTK2 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420233", "l": "VIP receptors bind VIP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374899", "l": "Release of noradrenaline  at the synapse (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641206", "l": "RSPOs bind LGRs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57160", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928656", "l": "gamma-secretase cleaves EPHB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12460", "l": "(S)-malate = fumarate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.2", "l": "\"fumarate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68221", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol => (7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044750", "l": "high-affinity nickel cation transmembrane transporter activity", "d": ["Catalysis of the high-affinity transfer of nickel (Ni) cations from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33928", "l": "4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 => 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15046", "l": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) => H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604732", "l": "Autocatalytic activation of proMMP13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59975", "l": "decanoyl-CoA + L-seryl-[protein] <=> CoA + O-decanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051266", "l": "sirohydrochlorin ferrochelatase activity", "d": ["Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13933", "l": "all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10396", "l": "an L-alpha-amino acid + H2O + NAD(+) = a 2-oxocarboxylate + H(+) + NADH + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.1.5", "l": "\"L-amino-acid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202722", "l": "CD48 binds CD244 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66765", "l": "ATP + folate(in) + H2O => ADP + folate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64388", "l": "4 A + sn-3-O-phytanylglycerol 1-phosphate = 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37610", "l": "(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63667", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH <=> H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54545", "l": "1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine => 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168891", "l": "Binding of NS1 to dsRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734540", "l": "ACLY tetramer binds ETC-1002-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15108", "l": "kaempferol + S-adenosyl-L-methionine <=> H(+) + kaempferide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21800", "l": "all-trans-antheraxanthin + L-ascorbate = all-trans-zeaxanthin + H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936667", "l": "sulfate binds to SubI outside the membrane (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429101", "l": "HMIT co-transports myo-inositol with a proton (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20362", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45180", "l": "2 (E)-4-coumaroyl-CoA + spermidine = 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine", "d": [], "t": []}, {"i": "EC:2.3.1.249", "l": "\"spermidine dicoumaroyl transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944246", "l": "Association of procollagen type XXI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008898", "l": "S-adenosylmethionine-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37747", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine = 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75649", "l": "(8R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33136", "l": "malonate(in) + Na(+)(in) => malonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32634", "l": "erythromycin D + H(+) + NADPH + O2 <=> erythromycin C + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77931", "l": "N-(4-oxobutylpyrrolinium) ion = 1-formylpyrrolizidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696958", "l": "USP44 deubiquitinates CDC20 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265177", "l": "Exocyst complex formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004727", "l": "prenylated protein tyrosine phosphatase activity", "d": ["Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71311", "l": "chloride(out) + L-alanine(out) + 2 Na(+)(out) = chloride(in) + L-alanine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798373", "l": "MDM2 ubiquitinates DYRK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17711", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-nonaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70628", "l": "H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50826", "l": "14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76803", "l": "2-aminopentan-1-ol + H2O + NAD(+) = 1-hydroxypentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.72", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-984671", "l": "Chromokinesins form dimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70110", "l": "(S)-5-carboxymethyl-tetronate + o-quinone methide <=> H(+) + penilactone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39551", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH = (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62029", "l": "H2O + stigmasteryl 3-beta-D-glucoside => D-glucose + stigmasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30234", "l": "H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine <=> (2E,6E)-farnesal + H2O2 + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653886", "l": "B4GALT1 binds LALBA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64096", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] = 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71488", "l": "H2O + Leu-enkephalin => L-phenylalanyl-L-leucine + L-tyrosylglycylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71444", "l": "3-O-methyl-L-dopa(out) + L-phenylalanine(in) => 3-O-methyl-L-dopa(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165195", "l": "GTP loading by Rheb (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68094", "l": "a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+) => a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.626324443255655", "identifiers": [{"i": "GO:0042277", "l": "peptide binding", "d": ["Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60819", "l": "2-oxoglutarate + gibberellin A14 aldehyde + O2 <=> CO2 + gibberellin A14 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428127", "l": "SPTLC complexes transfer acyl-CoA onto serine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753634", "l": "GGT dimers hydrolyse APAP-SG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75657", "l": "(8R)-hydroperoxy-(9Z)-octadecenoate => (9Z)-octadecenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28161", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657641", "l": "ALKBH2 binds alkylated DNA containing 1-meA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40978", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O <=> 2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211193", "l": "Homodimerization  of DFF40 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18352", "l": "ATP + L-aspartate + tRNA(Asx) <=> AMP + diphosphate + L-aspartyl-tRNA(Asx)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045523", "l": "interleukin-27 receptor binding", "d": ["Binding to an interleukin-27 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53292", "l": "H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin = H(+) + N-carbamoyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51883", "l": "3,4,6-trichlorocatechol + O2 <=> (2Z,4E)-2,3,5-trichloromuconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050388", "l": "uronate dehydrogenase activity", "d": ["Catalysis of the reaction: D-galacturonate + H2O + NAD+ = galactarate + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-901047", "l": "Binding of ERp57 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30478", "l": "H2O + oroxylin A 7-O-beta-D-glucuronate <=> D-glucuronate + H(+) + oroxylin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49971", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74952", "l": "(3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + 2-oxoglutarate + O2 => (3R)-3-isocyanylbutanoate + 2 CO2 + 2 H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61055", "l": "(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32391", "l": "(1R,2R,4R)-dihydrocarveol + NAD(+) = (1R,4R)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210282", "l": "Interaction of GPVI and FceRI gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50123", "l": "taurine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018837", "l": "2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63218", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18406", "l": "H2O + L-alanine + NAD(+) => H(+) + NADH + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9035227", "l": "TXN2 binds CysS248-MPST (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72289", "l": "2,2-dimethylsuccinate(in) + 3 Na(+)(in) => 2,2-dimethylsuccinate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654603", "l": "Activated FGFR2 binds FRS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37056", "l": "3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate => 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.11", "l": "\"guluronate-specific alginate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15633", "l": "3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.15", "l": "\"3,4-dihydroxyphenylacetate 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76563", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acylsphing-14Z-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35077", "l": "doxorubicin(out) + H(+)(in) => doxorubicin(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9011595", "l": "GSTZ1 dimer dehalogenates DCA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045127", "l": "N-acetylglucosamine kinase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0004035", "l": "alkaline phosphatase activity", "d": ["Catalysis of the reaction: a phosphate monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39785", "l": "(17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41157", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+) => 1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71192", "l": "an L-alpha-amino acid(in) + L-kynurenine(out) => an L-alpha-amino acid(out) + L-kynurenine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5221061", "l": "TDG excises 5-carboxylcytosine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66843", "l": "asperterpenoid A + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> asperterpenoid B + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63182", "l": "H(+) + NADP(+) + 2 superoxide => NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12099", "l": "H2O + N-benzylformamide <=> benzylamine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28205", "l": "2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate <=> 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34705", "l": "(E)-2-epi-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170120", "l": "Translocation of Cdc25B to the cytoplasm (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30360", "l": "chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 => chlorophyllide b + 3 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71960", "l": "3 Na(+)(out) + oxaloacetate(out) => 3 Na(+)(in) + oxaloacetate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951499", "l": "Loading of antigenic peptides on to class I MHC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110011", "l": "Binding of Grb10 to the insulin receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16244", "l": "an NDP-alpha-D-glucose + D-fructose <=> a ribonucleoside 5'-diphosphate + H(+) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57346", "l": "3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-D-kynurenine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11769", "l": "diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate => 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53498", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate => 1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549304", "l": "OCT3 mediates renal clearance of organic cations (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41447", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 <=> glycine + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770142", "l": "Formation of the Spliceosomal B complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34847", "l": "7,8-dihydromonapterin + H(+) + NADPH = 5,6,7,8-tetrahydromonapterin + NADP(+)", "d": [], "t": []}, {"i": "EC:1.5.1.50", "l": "\"dihydromonapterin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990080", "l": "2-phenylethylamine receptor activity", "d": ["Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672817", "l": "Active MTORC1 binds the ULK1 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12892", "l": "L-gulonate + NAD(+) <=> 3-dehydro-L-gulonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381086", "l": "Dissociation of PERK:BiP Heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65984", "l": "hnu + previtamin D3 = lumisterol 3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380780", "l": "Activation of Src (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047432", "l": "2,2-dialkylglycine decarboxylase (pyruvate) activity", "d": ["Catalysis of the reaction: 2,2-dialkylglycine + H+ + pyruvate = L-alanine + CO2 + dialkyl ketone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70969", "l": "3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out) => 3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174202", "l": "Degradation of multiubiquitinated Securin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67336", "l": "kaempferol 3-O-beta-D-glucoside + malonyl-CoA = CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69916", "l": "guanosine(out) + 2 Na(+)(out) => guanosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111962", "l": "PDE4A,C,D hydrolyse cAMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56268", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34359", "l": "a 1,2-diacylglycerol + H2O = a 2-acylglycerol + a carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66989", "l": "4-methylpentanoate + ATP + CoA => 4-methylpentanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13014", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23729", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 => A + H2O + prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683831", "l": "CCDC59 binds TTF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983152", "l": "Transfer of ubiquitin from E1 to E2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299297", "l": "Activation of THIK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72275", "l": "oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66760", "l": "ATP + H2O + kainate(in) = ADP + H(+) + kainate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17962", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => H2O + leukotriene A4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41391", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43313", "l": "ATP + N-(hexanoyl)sphing-4-enine => ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46683", "l": "2 Fe(III)-[cytochrome b5] + NADH <=> 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856466", "l": "MITF-M dimer binds RAB27A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018814", "l": "phenylacetaldoxime dehydratase activity", "d": ["Catalysis of the reaction: (trans)-phenylacetaldoxime = H2O + phenylacetonitrile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42969", "l": "cytidine(56) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33407", "l": "ATP + glycine + H(+) = diphosphate + glycyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139893", "l": "Granzyme-B activates BID by cleavage (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375140", "l": "CDO binds promyogenic cadherins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76965", "l": "2-hexyl-5-(7-hydroxyheptyl)resorcinol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-hexyl-5-heptylresorcinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098620", "l": "seryl-selenocysteinyl-tRNA kinase activity", "d": ["Catalysis of the reaction: Ser-tRNA(Sec) + ATP = Sep-tRNA(Sec) + ADP."], "t": []}, {"i": "REACT:R-HSA-2408507", "l": "Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836270", "l": "TFAP2A binds TFAP2C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70689", "l": "4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in) => 4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17859", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate => O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399992", "l": "AKT1 E17K mutant phosphorylates forkhead box transcription factors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73228", "l": "(3R)-citramalate(in) + sulfate(out) => (3R)-citramalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38289", "l": "(3S)-citramalyl-CoA + succinate => (3S)-citramalate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373734", "l": "Nephrin interacts with Podocin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008933", "l": "lytic transglycosylase activity", "d": ["Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32008", "l": "9alpha-copalyl diphosphate => diphosphate + isopimara-8(14),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62219", "l": "isoepoxydon + NADP(+) <=> H(+) + NADPH + phyllostine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31127", "l": "3-O-methylgallate + O2 = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19598", "l": "H2O + L-arginine => L-citrulline + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50085", "l": "ATP + H2O + taurolithocholate 3-sulfate(in) => ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57869", "l": "(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 => (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69686", "l": "daidzein 7-O-beta-D-glucoside + H2O <=> beta-D-glucose + daidzein + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63155", "l": "an N-fatty acyl-taurine + H2O <=> a fatty acid + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10346", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090541", "l": "MIT domain binding", "d": ["Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357445", "l": "PAK1-3 dimer disassociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63051", "l": "H2O + pravastatin lactone <=> H(+) + pravastatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698844", "l": "MLKL binds HSP90:CDC37 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690669", "l": "CD22 binds itself to form homo-oligomers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902670", "l": "carbon dioxide binding", "d": ["Binding to carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32601", "l": "3-isopropenyl-6-oxoheptanoate + H(+) => 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67847", "l": "a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183072", "l": "EGFR non-clathrin mediated endocytosis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20842", "l": "CO2 + histamine => H(+) + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045514", "l": "interleukin-16 receptor binding", "d": ["Binding to an interleukin-16 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39325", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+) => (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49598", "l": "H(+) + N-acyl-D-galactosylsphing-4-enine + UDP => an N-acylsphing-4-enine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-378975", "l": "Follitropin is a heterodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43693", "l": "ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11676", "l": "D-ribose + H2O + NADP(+) = D-ribonate + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.115", "l": "\"ribose 1-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061654", "l": "NEDD8 conjugating enzyme activity", "d": ["Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue."], "t": []}, {"i": "EC:2.3.2.34", "l": "\"E2 NEDD8-conjugating enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211224", "l": "Association of DFF40 with DFF45 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58104", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428909", "l": "Activated TP receptor binds G-protein  G13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53433", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45771", "l": "gamma-L-glutamyl-L-alaninol + H2O <=> L-alaninol + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18581", "l": "ethanolamine + H2O + O2 = glycolaldehyde + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.3.8", "l": "\"ethanolamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839381", "l": "FGF2:TGFBR3 binding to GIPC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004967", "l": "glucagon receptor activity", "d": ["Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38199", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618582", "l": "CEBPA binds MYC gene:E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76523", "l": "2-dehydro-3-deoxy-L-fuconate = (S)-lactaldehyde + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.2.64", "l": "\"2-dehydro-3-deoxy-L-fuconate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.2", "l": "\"non-specific protein-tyrosine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16472", "l": "(R)-2-benzylsuccinate + succinyl-CoA <=> (R)-2-benzylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70490", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2 <=> a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78469", "l": "a ganglioside GM3 + CMP + H(+) => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.55", "l": "\"caspase-2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35934", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30202", "l": "2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate <=> 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46828", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17942", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate => 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18338", "l": "D-ribose 5-phosphate + uracil => H2O + psi-UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877902", "l": "Activated AR binds RUNX2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76653", "l": "3-methylbutanoate + 2 H(+) + NADPH => 3-methylbutanal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390909", "l": "HRH2 binds hist (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454916", "l": "The ABCC family mediates organic anion transport (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1015702", "l": "Expression of IFN-induced genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.19", "l": "\"cis-1,2-dihydrobenzene-1,2-diol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848250", "l": "ACBD6 binds LCFA-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77255", "l": "beta-D-glucosylceramide(in) = beta-D-glucosylceramide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75542", "l": "(2E)-decenoate + ATP + holo-[ACP] <=> (2E)-decenoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47351", "l": "a butanoate ester + H2O <=> an aliphatic alcohol + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48986", "l": "2,4-dichlorophenol + CO2 + glyoxylate + succinate => (2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52399", "l": "4-O-phospho-D-threonate + NAD(+) <=> CO2 + dihydroxyacetone phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34011", "l": "5-dehydroepisterol + 2 H2O + NADP(+) = ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030374", "l": "nuclear receptor coactivator activity", "d": ["A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.12", "l": "\"ABC-type cystine transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74692", "l": "2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine => 4 5'-deoxyadenosine + 2 A + a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 H(+) + 4 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627056", "l": "Procaspase 9 forms dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63422", "l": "cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate => 2-hydroxyethylphosphonate + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660666", "l": "CBP and p300 binds NF-kB complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159733", "l": "Furin cleaves pro-factor X to factor X (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853496", "l": "SCF:FBXL7 binds AURKA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112037", "l": "Inactivation of PLC beta (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63129", "l": "H2O + N-docosanoyl-ethanolamine => docosanoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54813", "l": "(+)-7-isojasmonate + ATP + L-isoleucine => AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928657", "l": "MMP2,9 cleave EPHB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9825790", "l": "p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38048", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938913", "l": "RUNX1 binds ELF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49366", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate => 17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40200", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.25", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17262", "l": "an aryl sulfate + H2O => a phenol + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68226", "l": "CO2 + H2O + kainate lactone + succinate => 2-oxoglutarate + H(+) + O2 + prekainate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41381", "l": "H(+) + NADH + O2 + toluene => 4-methylphenol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757574", "l": "ALB binds PREDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981713", "l": "C4b binds to cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55236", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O = (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10482", "l": "4-hydroxy-2-oxoglutarate + L-glutamate => 2-oxoglutarate + 4-hydroxy-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64229", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23076", "l": "4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH", "d": [], "t": []}, {"i": "EC:1.21.1.2", "l": "\"2,4-dichlorobenzoyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-179421", "l": "Degradation of multiubiquitinated Nek2A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21260", "l": "[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (R)-S-oxide", "d": [], "t": []}, {"i": "EC:1.8.4.14", "l": "\"L-methionine (R)-S-oxide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5444516", "l": "Formation of MSH2:MSH6 Complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12811", "l": "2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O => 4 catechol + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70453", "l": "a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate => 2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35760", "l": "8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8987214", "l": "p-STAT3 dimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24966", "l": "calcitetrol + H2O + 2 oxidized [adrenodoxin] => calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69922", "l": "inosine(out) + 2 Na(+)(out) <=> inosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008506", "l": "sucrose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52287", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27799", "l": "(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate => all-trans-octaprenyl diphosphate + 5 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69103", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24075", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48011", "l": "2-hydroxybenzoyl-CoA + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798372", "l": "ATM phosphorylates DYRK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48887", "l": "NADP(+) + protochlorophyllide a <=> 3,8-divinyl protochlorophyllide a + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46798", "l": "an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029460", "l": "PAK1 phosphorylates LIMK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928657", "l": "MMP2,9 cleave EPHB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9761027", "l": "ZEB2 binds SP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42461", "l": "dibenzofuran + H(+) + NADH + O2 => biphenyl-2,2',3-triol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41667", "l": "dihydrochelirubine + NAD(+) <=> chelirubine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62979", "l": "(9Z,12Z,15Z)-octadecatrienamide + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14592", "l": "luteolin + S-adenosyl-L-methionine <=> chrysoeriol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.82", "l": "\"malate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13421", "l": "an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate = an N-acylneuraminate 9-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.57", "l": "\"N-acylneuraminate-9-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2464822", "l": "RDH12 reduces atRAL to atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29854", "l": "H2O + UDP-N-acetyl-alpha-D-galactosamine <=> 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102632", "l": "(S)-nandinine synthase activity", "d": ["Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-nandinine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033460", "l": "GAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GAG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0031992", "l": "energy transducer activity", "d": ["The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009558", "l": "IL34 dimer binds SDC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73482", "l": "D-histidine(in) + H(+)(in) + L-ornithine(out) <=> D-histidine(out) + H(+)(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62193", "l": "O2 + peregrinol + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55849", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37938", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004339", "l": "glucan 1,4-alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37930", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205321", "l": "Interaction of KIT and sSCF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22526", "l": "a carotenoid phi-end derivative + 2 AH2 => 2 A + a carotenoid beta-end derivative", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12491", "l": "2-amino-2-deoxy-D-gluconate <=> 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140837", "l": "RNA polymerase II CTD heptapeptide repeat S7 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 7)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52199", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-aci-nitro-2-(phenyl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74461", "l": "1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in) => 1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27283", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59428", "l": "3-hydroxypropanal + H2O + NADP(+) = 3-hydroxypropanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940554", "l": "MMP2 cleaves OPTC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65500", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:4.1.99.26", "l": "\"3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032502", "l": "Activated NTRK2 binds FYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679239", "l": "ULK complex translocates to the ER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68898", "l": "4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+) => 4-hydroxybenzoate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59938", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+) => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65800", "l": "a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O = a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48858", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52259", "l": "a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34194", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5227009", "l": "ABCF1 binds EIF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13845", "l": "dihydroxyfumarate + H(+) = 2-hydroxy-3-oxopropanoate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.54", "l": "\"dihydroxyfumarate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379982", "l": "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007647", "l": "E2F6 binds CBX5 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76060", "l": "RNA Polymerase III Promoter Opening at Type 1 Promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11742", "l": "glutathione disulfide + H(+) + NADPH => 2 glutathione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086041", "l": "voltage-gated potassium channel activity involved in SA node cell action potential depolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74572", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] => N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042657", "l": "MHC class II protein binding, via lateral surface", "d": ["Binding to the lateral surface of major histocompatibility complex class II molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42356", "l": "(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350400", "l": "PK binds to DSH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49517", "l": "2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2 => an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46538", "l": "a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679239", "l": "ULK complex translocates to the ER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772430", "l": "CTNNBIP1 binds beta-catenin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27883", "l": "2',3'-cyclophospho-CMP + H2O => 3'-CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13305", "l": "(E)-sinapate + UDP-alpha-D-glucose = 1-O-(trans-sinapoyl)-beta-D-glucose + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.120", "l": "\"sinapate 1-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68595", "l": "ORC2 binds ORC3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38843", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768762", "l": "NPAS4 gene transcription in non-neuronal cells is repressed by REST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14225", "l": "6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.258", "l": "\"6-hydroxyhexanoate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795473", "l": "PDPK1 phosphorylates SGK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77934", "l": "N-(4-oxobutylpyrrolinium) ion <=> 1-formylpyrrolizidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28675", "l": "alpha-D-galactose = beta-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17779", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+) => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.142", "l": "\"limit dextrinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54296", "l": "GTP + L-tyrosyl-[protein] = diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.7.n6", "l": "\"guanine phosphate-protein transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27687", "l": "ATP + GDP => ADP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54057", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-hedycaryol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46215", "l": "H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine <=> 4-amino-5-aminomethyl-2-methylpyrimidine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24763", "l": "H(+) + L-dopa + NADH <=> 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047671", "l": "cyclopeptine synthase activity", "d": ["Catalysis of the reaction: anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine = 2 AMP + cyclopeptine + 2 diphosphate + 2 H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44325", "l": "1-butyrylglycerol + H2O => butanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72933", "l": "atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64167", "l": "2-methyl-L-serine <=> formaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008927", "l": "mannonate dehydratase activity", "d": ["Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103067", "l": "4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19185", "l": "glyoxylate + H2O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.11", "l": "\"2-hydroxyglutarate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849900", "l": "SALMs1-3 bind each other in cis interactions (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050006", "l": "isomaltulose synthase activity", "d": ["Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9825788", "l": "p-S207 KARS displaces HINT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63467", "l": "(2E,6E,10E)-geranylgeraniol + UTP <=> (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611751", "l": "β1,2-agonists bind ADRB1,2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20303", "l": "AMP + diphosphate + L-arginyl-tRNA(Arg) => ATP + L-arginine + tRNA(Arg)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709317", "l": "CO binds to free ferrohemoglobin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24897", "l": "5-hydroxyxanthotoxin + S-adenosyl-L-methionine <=> isopimpinellin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47616", "l": "ethionamide + H(+) + NADPH + O2 = ethionamide S-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031799", "l": "type 2 metabotropic glutamate receptor binding", "d": ["Binding to a type 2 metabotropic glutamate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38786", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102842", "l": "1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity (SN2-16:3 forming)", "d": ["Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851118", "l": "pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052580", "l": "(+)-pulegone reductase, (-)-menthone as substrate, activity", "d": ["Catalysis of the reaction: (-)-menthone + NADP+ = (+)-pulegone + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106350", "l": "octaprenyl pyrophosphate synthase activity", "d": ["Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851018", "l": "BTN2A1 binds DC-SIGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49461", "l": "(2Z,4E)-2-aminomuconate + H2O => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71401", "l": "OGDH dimer decarboxylates 2-OG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73510", "l": "7,8-dihydroxyflavone + S-adenosyl-L-methionine <=> 7-hydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836275", "l": "TFAP2A binds TFAP2B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18681", "l": "phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": [], "t": []}, {"i": "EC:2.5.1.7", "l": "\"UDP-N-acetylglucosamine 1-carboxyvinyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380574", "l": "Dopamine synaptic vesicle docking and priming (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57555", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29012", "l": "2-oxoglutarate(in) + H(+)(in) => 2-oxoglutarate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42289", "l": "6-carboxyhexanoyl-[ACP] + H(+) + L-alanine => (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57264", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP = GDP + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77331", "l": "glyoxylate + L-ornithine = 5-amino-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821395", "l": "PAXIP1 binds PAGR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33426", "l": "N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) <=> diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177284", "l": "PKA phosphorylates PDE4B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296301", "l": "CCRL2 binds CCL19 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11496", "l": "O-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}, {"i": "EC:2.5.1.53", "l": "\"uracilylalanine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29940", "l": "H(+)(in) + phosphate(in) => H(+)(out) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623643", "l": "RDH13 reduces atRAL to atROL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933526", "l": "Recruitment of caspase-8 and -10 to FADD complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33310", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] <=> (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73135", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine = 4',7-dihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54295", "l": "ATP + L-threonyl-[protein] <=> 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617927", "l": "FOXO4 binds ATXN3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18086", "l": "coenzyme B + coenzyme M + methanophenazine => coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693609", "l": "ATM phosphorylates TP53 at S15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39033", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68383", "l": "3-hydroxypyruvate + L-asparagine <=> 2-oxosuccinamate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28812", "l": "2,3-dioxo-L-gulonate(in) + Na(+)(in) => 2,3-dioxo-L-gulonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68420", "l": "cis-(homo)3aconitate + H2O = (2R,3S)-iso(homo)3citrate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72229", "l": "chloride(in) + 2 Na(+)(in) + sarcosine(in) => chloride(out) + 2 Na(+)(out) + sarcosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19292", "l": "H2O + sucrose 6(F)-phosphate <=> phosphate + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16448", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone <=> daidzein + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033849", "l": "chrysanthemyl diphosphate synthase activity", "d": ["Catalysis of the reaction: 2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23017", "l": "(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) => (2R,3R)-dihydrokaempferol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29156", "l": "2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) => 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14537", "l": "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.20", "l": "\"pyrithiamine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111930", "l": "Adenylate cyclase produces cAMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004139", "l": "deoxyribose-phosphate aldolase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033704", "l": "3beta-hydroxy-5alpha-steroid dehydrogenase activity", "d": ["Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ = 5alpha-pregnane-3,20-dione + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30556", "l": "GTP + L-glutamate + oxidized coenzyme F420-0 => GDP + H(+) + oxidized coenzyme F420-1 + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57192", "l": "H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] = glycolate + H(+) + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30564", "l": "dimethylallyl diphosphate + L-tryptophan => 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17905", "l": "(R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21040", "l": "CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.2.7.4", "l": "\"anaerobic carbon-monoxide dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56869", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA => (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59811", "l": "L-tyrosine <=> D-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43565", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine => [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59118", "l": "[protein]-disulfide + H2O2 => [protein]-dithiol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099620", "l": "UDP-4-amino-4-deoxy-L-arabinose aminotransferase", "d": ["Catalysis of the reaction: UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10528", "l": "dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.100", "l": "\"dihydrosanguinarine 10-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13879", "l": "an L-alpha-amino acid + L-glutamate 5-semialdehyde => a 2-oxocarboxylate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61648", "l": "ATP + holo-[ACP] + salicylate = AMP + diphosphate + salicyl-[ACP]", "d": [], "t": []}, {"i": "EC:6.2.1.61", "l": "\"salicylate--[aryl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21060", "l": "3,4-dichloroaniline + malonyl-CoA = CoA + N-(3,4-dichlorophenyl)malonamate", "d": [], "t": []}, {"i": "EC:2.3.1.114", "l": "\"3,4-dichloroaniline N-malonyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-500708", "l": "GRIK3 homomer binds glutamate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750666", "l": "ALB binds ST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9656893", "l": "OPN1MW binds 11cRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990135", "l": "flavonoid sulfotransferase activity", "d": ["Catalysis of the reaction: a flavonoid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated flavonoid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a flavonoid acceptor, producing the sulfated flavonoid derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72469", "l": "6 CO2 + 8 CoA + H2O + o-orsellinate depside => 2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48414", "l": "a globoside Gb4Cer + N-acetyl-alpha-D-galactosamine => a globoside IV3GalNAc-Gb4Cer + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45205", "l": "Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol => H2O + methyl-Co(III)-[methanol-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952128", "l": "RUNX3 binds TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40569", "l": "A + dTDP-beta-L-evernitrose + H2O => AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.53", "l": "\"trimerelysin II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64345", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 => 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78014", "l": "a 1,3-diacyl-2-(9Z,12Z-octadecadienoyl)-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine <=> a 1,3-diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534378", "l": "Hv1 Mediated H+ Permeability (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20021", "l": "2-oxoglutarate + deoxyamidinoproclavaminate + O2 = amidinoproclavaminate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74636", "l": "2-oxoglutarate + 5-dehydro-6-demethoxyfumagillol + O2 => 5-dehydro-6-demethoxy-6-hydroxyfumagillol + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52535", "l": "adenosine + GTP <=> AMP + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809680", "l": "MTMR12 binds MTM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44623", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799733", "l": "Semiquinone reacts with oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130706", "l": "MHC class II antigen processing (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16500", "l": "adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51309", "l": "H(+) + L-methionyl-[F-actin] + NADPH + O2 => H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46890", "l": "3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + H2O2 => 3-deoxy-alpha-D-manno-oct-2-ulosonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050251", "l": "retinol isomerase activity", "d": ["Catalysis of the reaction: all-trans-retinol = 11-cis-retinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9865449", "l": "Metallochaperone inserts Cu2+ into MT-CO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696605", "l": "USP12, USP26 deubiquitinate AR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875374", "l": "MET binds LRIG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177942", "l": "EGFR binds EGF ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26496", "l": "7-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40884", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0046995", "l": "oxidoreductase activity, acting on hydrogen as donor, with other known acceptors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound."], "t": []}, {"i": "EC:1.12.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944233", "l": "Association of procollagen type XIX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070840", "l": "dynein complex binding", "d": ["Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28791", "l": "5,6-dihydrothymine + NAD(+) = H(+) + NADH + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65998", "l": "methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine => Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32241", "l": "all-trans-beta-carotene => gamma-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10734", "l": "AMP + CO2 + diphosphate + firefly oxyluciferin + hnu => ATP + firefly D-luciferin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660013", "l": "Defective RPIA does not isomerize RU5P to R5P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709571", "l": "BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2471621", "l": "Endostatin degradation by cathepsins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75029", "l": "2,3-di-(9Z)-hexadecenoyl-sn-glycerol + 9-(9Z-hexadecenoyloxy)-octadecanoate => 1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876258", "l": "CBL monoubiquitinates InlB-bound MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22796", "l": "ATP + D-hamamelose = ADP + D-hamamelose 2'-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.102", "l": "\"hamamelose kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16034", "l": "2-oxoglutarate + gibberellin A44 + O2 => CO2 + gibberellin A19 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783880", "l": "PIPOX oxidises PPCA to P6C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "56.353495009216743", "identifiers": [{"i": "GO:0016301", "l": "kinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202174", "l": "Activation of ZAP-70 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12653", "l": "(S)-malate + NAD(+) = CO2 + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16733", "l": "H(+) + orsellinate = CO2 + orcinol", "d": [], "t": []}, {"i": "EC:4.1.1.58", "l": "\"orsellinate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69272", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate = allyl isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213241", "l": "Formation of nonameric complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19626", "l": "L-threonine => acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70163", "l": "H(+)(in) + methotrexate(in) = H(+)(out) + methotrexate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70280", "l": "H2O + stachyose => D-galactose + raffinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64736", "l": "4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15438", "l": "a long-chain fatty aldehyde + CoA + NADP(+) => a long-chain fatty acyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333051", "l": "RPA1 binds HSF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781897", "l": "USP11 deubiquitinates NFKBIA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22185", "l": "(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) => acenaphthene-1,2-dione + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43504", "l": "5-hydroxymethylfurfural + O2 = 2,5-diformylfuran + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70831", "l": "L-arginine(in) + L-leucine(out) + Na(+)(out) = L-arginine(out) + L-leucine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005151", "l": "interleukin-1, type II receptor binding", "d": ["Binding to a Type II interleukin-1 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67032", "l": "4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67345", "l": "kaempferol 7-O-beta-D-glucoside + malonyl-CoA => CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78750", "l": "an alpha-L-rhamnosyl-(1->4)-beta-D-glucuronide <=> a 4-deoxy-alpha-L-threo-hex-4-enopyranuronoside + L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004494", "l": "methylmalonyl-CoA mutase activity", "d": ["Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32532", "l": "4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate => alpha-D-mannose 1-phosphate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69496", "l": "decan-1-ol + O2 = decanal + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.11", "l": "\"cholesterol-5,6-oxide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033437", "l": "ACU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46894", "l": "3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate => 2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20689", "l": "chlorogenate + H2O = (E)-caffeate + H(+) + L-quinate", "d": [], "t": []}, {"i": "EC:3.1.1.42", "l": "\"chlorogenate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106265", "l": "THPH synthase activity", "d": ["Catalysis of the reaction: 3 H+ + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA."], "t": []}, {"i": "RHEA:64352", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64689", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33997", "l": "5-oxo-L-proline + butirosin B => gamma-L-glutamyl-butirosin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014449", "l": "RHOG binds effectors at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49165", "l": "a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170012", "l": "histone H3K18 decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone H3 position 18] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone H3] + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9825783", "l": "p-S207 KARS1 dimer translocates to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66331", "l": "taurine(out) <=> taurine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19078", "l": "H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] => 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605717", "l": "GM2A binds and mobilizes ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13832", "l": "GDP-alpha-D-rhamnose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74547", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + talarodiene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72181", "l": "2 Na(+)(in) + tauro-beta-muricholate(in) => 2 Na(+)(out) + tauro-beta-muricholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850945", "l": "Casein kinase II phosphorylates PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70542", "l": "GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein] <=> 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010385", "l": "double-stranded methylated DNA binding", "d": ["Binding to double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61887", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52994", "l": "[deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine => [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56556", "l": "(2E,6E)-farnesyl diphosphate = delta-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66746", "l": "ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378952", "l": "Thyrotropin is a heterodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39223", "l": "(3R)-hydroxyoctacosanoyl-CoA = (2E)-octacosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36163", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.21", "l": "\"nicotinate phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73737", "l": "3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde => O2 + trans-resveratrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0005504", "l": "fatty acid binding", "d": ["Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031370", "l": "eukaryotic initiation factor 4G binding", "d": ["Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15282", "l": "lathosterol => 5alpha-cholest-8-en-3beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32129", "l": "cis-4-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + L-proline + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983688", "l": "OAS1 oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25732", "l": "H(+) + N,N-dihydroxy-L-tetrahomomethionine => (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61103", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28492", "l": "H(+)(out) + K(+)(out) => H(+)(in) + K(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18756", "l": "[protein]-dithiol + NADP(+) <=> [protein]-disulfide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68708", "l": "(2E)-geranyl diphosphate + H2O = diphosphate + linalool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30294", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9860290", "l": "TASL recruits IRF5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9006873", "l": "IL21 receptor STAT binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20923", "l": "2,4-dichlorophenol + H(+) + NADPH + O2 <=> 3,5-dichlorocatechol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35466", "l": "lathosterol + NAD(+) <=> 5alpha-cholest-7-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26263", "l": "2 H(+) + isopimarate + NADPH => H2O + isopimara-7,15-dienal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211951", "l": "CYP1B1 4-hydroxylates EST17b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112703", "l": "PTPN11 is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76461", "l": "(E)-sinapaldehyde + AH2 => (E)-sinapyl alcohol + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-919404", "l": "Phosphorylated STAT5 is released (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683774", "l": "p-T68-CHEK2 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55550", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61350", "l": "ADP + estrone 3-sulfate(out) + H(+) + phosphate => ATP + estrone 3-sulfate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56096", "l": "[protein]-C-terminal Gly-Gly + ATP + H(+) = [protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977237", "l": "IRAK2 binds to IRAK4 associated with activated TLR : MyD88 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202459", "l": "Phosphorylation of Bcl10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798372", "l": "ATM phosphorylates DYRK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950737", "l": "IL23R binds JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51743", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A <=> a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592316", "l": "Initial activation of proMMP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66703", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265177", "l": "Exocyst complex formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67885", "l": "3'-phosphoadenylyl sulfate + dopamine => adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58153", "l": "H2O + NAD(+) + phosphonoacetaldehyde => 2 H(+) + NADH + phosphonoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800298", "l": "HGF dimer binds MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172433", "l": "Collagen type XIX degradation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18240", "l": "2,5-dihydroxybenzoate + O2 <=> 3-maleylpyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247840", "l": "WLS binds WNT ligands in the Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47618", "l": "ethionamide S-oxide + H2O + NADP(+) => ethionamide + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56336", "l": "ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.76", "l": "\"ent-isokaurene C2/C3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682020", "l": "MRN complex binds shortened telomeres (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56943", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849428", "l": "PTPN1 binds PTK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49534", "l": "ethylene glycol + H(+) + terephthalate => 4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20919", "l": "L-cysteine + sulfite <=> hydrogen sulfide + L-cysteate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18911", "l": "2,4,6-trichloroanisole + S-adenosyl-L-homocysteine => 2,4,6-trichlorophenol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022880", "l": "protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50569", "l": "acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052741", "l": "(R)-limonene 6-monooxygenase activity", "d": ["Catalysis of the reaction: (4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51023", "l": "a primary alcohol + 2 Fe(III)-[cytochrome c] <=> an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19254", "l": "a sphingomyelin + H2O => an N-acylsphing-4-enine + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429101", "l": "HMIT co-transports myo-inositol with a proton (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78345", "l": "5'-GpA(2'-5') + phosphate => 5'-pGpA(2'-5') + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26200", "l": "H2O + melamine <=> ammeline + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73956", "l": "3,4-dihydroxystyrene + H(+) + NADH => 4-ethylcatechol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55873", "l": "anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) => 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68157", "l": "(2E)-geranyl diphosphate + L-glutamate => diphosphate + N-geranyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75129", "l": "codeinone => neopinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56803", "l": "apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide <=> cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21154", "l": "cis-4-hydroxy-D-proline => trans-4-hydroxy-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004143", "l": "ATP-dependent diacylglycerol kinase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62509", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18088", "l": "coenzyme B + coenzyme M + methanophenazine <=> coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68553", "l": "NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine => H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607043", "l": "factor VIIIa associates with cell membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21213", "l": "H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14008", "l": "H2O + L,L-cystathionine <=> 2-oxobutanoate + L-cysteine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0097363", "l": "protein O-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42627", "l": "(Z)-3-ureidoacrylate + H(+) + H2O <=> (Z)-3-aminoacrylate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19537", "l": "D-mannitol 1-phosphate + H2O = D-mannitol + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.22", "l": "\"mannitol-1-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203611", "l": "N-myristoylation of eNOS (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047143", "l": "chlorate reductase activity", "d": ["Catalysis of the reaction: AH(2) + chlorate = A + chlorite + H2O + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57399", "l": "(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine <=> 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187828", "l": "Translocation of p21 to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660980", "l": "p-S276-RELA binds RELB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44657", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14772", "l": "(S)-nicotine + A + H2O <=> (S)-6-hydroxynicotine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9833635", "l": "p-PKR dimer localizes to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68050", "l": "[protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine => [protein]-D-aspartate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034781", "l": "N-cyclohexylformamide amidohydrolase activity", "d": ["Catalysis of the reaction: N-cyclohexylformamide + OH- = cyclohexylamine + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64143", "l": "an N-(fatty acyl)-L-asparagine + H2O <=> a fatty acid + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74600", "l": "AMP(out) + UDP-alpha-D-galactose(in) => AMP(in) + UDP-alpha-D-galactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654515", "l": "KAL1 binds HS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72414", "l": "inulobiose <=> alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211948", "l": "CYP3A4 can N-demethylate loperamide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12049", "l": "3-oxoadipate + succinyl-CoA => 3-oxoadipyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419645", "l": "Dimerization of LIMK1 by Hsp90 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69038", "l": "3beta-hydroxy-5beta-androstane-17-one + NADP(+) => 5beta-androstane-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42870", "l": "caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine => norspermine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33064", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin] => NADH + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16129", "l": "NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal", "d": [], "t": []}, {"i": "EC:1.1.1.65", "l": "\"pyridoxine 4-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43214", "l": "2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944223", "l": "Association of procollagen type V (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65582", "l": "H(+) + phosphate + TDP => H2O + TTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033727", "l": "aldehyde dehydrogenase (FAD-independent) activity", "d": ["Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10320", "l": "trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.77", "l": "\"trans-L-3-hydroxyproline dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1222491", "l": "Lactoferrin scavenges iron ions (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38161", "l": "(2S,3R)-capreomycidine + H2O => (2S,3S)-hydroxyarginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032942", "l": "inositol tetrakisphosphate 2-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097600", "l": "exoxylanase activity", "d": ["A xylanase activity that acts on one of the ends of a xylan polymer which does not contain side chains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033950", "l": "xyloglucan-specific exo-beta-1,4-glucanase activity", "d": ["Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70987", "l": "beta-alanine(out) + n H(+)(in) = beta-alanine(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36071", "l": "6-tuliposide A = D-glucose + tulipalin A", "d": [], "t": []}, {"i": "EC:4.2.99.22", "l": "\"tuliposide A-converting enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004990", "l": "oxytocin receptor activity", "d": ["Combining with oxytocin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21931", "l": "3-dehydro-L-gulonate + NADP(+) <=> 2,3-dioxo-L-gulonate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.1", "l": "\"steroid Delta-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357432", "l": "AXL binds SRC-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626914", "l": "α2-agonists bind ADRA2A,B,C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047707", "l": "biotin-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28698", "l": "hydrogencarbonate(in) <=> hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944569", "l": "miR-25 microRNA binds PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19476", "l": "4-hydroxybenzoate + H(+) + NADH + O2 <=> 3,4-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13050", "l": "D-glucuronate => D-fructuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63128", "l": "H2O + N-docosanoyl-ethanolamine = docosanoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54536", "l": "a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59191", "l": "L-histidine <=> D-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17879", "l": "a guaiacol + H(+) + S-adenosyl-L-homocysteine => a catechol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050396", "l": "vomifoliol 4'-dehydrogenase activity", "d": ["Catalysis of the reaction: (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD+ = (6S)-6-hydroxy-3-oxo-alpha-ionone + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56750", "l": "an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047259", "l": "glucomannan 4-beta-mannosyltransferase activity", "d": ["Catalysis of the reaction: glucomannan(n) + GDP-mannose = glucomannan(n+1) + GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73800", "l": "SAICAR => AICAR + Fumarate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29516", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55743", "l": "H2O + oleuropein <=> D-glucose + oleuropein aglycone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42498", "l": "10-deacetyl-2-debenzoylbaccatin III => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9769235", "l": "MAGED1 binds NPAS4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975160", "l": "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17416", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0051916", "l": "granulocyte colony-stimulating factor binding", "d": ["Binding to granulocyte colony-stimulating factor, G-CSF."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254291", "l": "ERBB4s80 binds STAT5A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050377", "l": "UDP-glucose 4,6-dehydratase activity", "d": ["Catalysis of the reaction: UDP-D-glucose = H2O + UDP-4-dehydro-6-deoxy-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29266", "l": "L-leucine(in) + Na(+)(in) <=> L-leucine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296127", "l": "Activation of voltage gated Potassium channels (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218821", "l": "PDK1 phosphorylates PKC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102590", "l": "delphinidin 3-O-rutinoside 7-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-rutinoside + 1-O-4-hydroxybenzoyl-beta-D-glucose = delphinidin 3-O-rutinoside-7-O-glucoside + 4-hydroxybenzoic acid + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30532", "l": "biotinate sulfoxide + H(+) + NADH => biotin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52715", "l": "dTMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.752469279128519", "identifiers": [{"i": "GO:0004620", "l": "phospholipase activity", "d": ["Catalysis of the hydrolysis of a glycerophospholipid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0070853", "l": "myosin VI binding", "d": ["Binding to a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64129", "l": "H2O + N-octadecanoyl-L-phenylalanine => L-phenylalanine + octadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371422", "l": "ATP hydrolysis by HSP70 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37813", "l": "1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45343", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O <=> (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35347", "l": "3-hydroxyoctadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76177", "l": "glycyl-L-glutamate(in) + 3 H(+)(in) => glycyl-L-glutamate(out) + 3 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46924", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA = 4-methylpent-2-enoyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.157", "l": "\"(R)-2-hydroxyisocaproyl-CoA dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953336", "l": "Expression of EXTL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22767", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69328", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate = 5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23098", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+) => 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60452", "l": "2-hydroxyethane-1-sulfonate = acetaldehyde + H(+) + sulfite", "d": [], "t": []}, {"i": "EC:4.4.1.38", "l": "\"isethionate sulfite-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50625", "l": "acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O => a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42561", "l": "uridine(27/28) in mitochondrial tRNA => pseudouridine(27/28) in mitochondrial tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15905", "l": "3-hydroxycyclohexanone + A = AH2 + cyclohexane-1,3-dione", "d": [], "t": []}, {"i": "EC:1.1.99.26", "l": "\"3-hydroxycyclohexanone dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75592", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (11S)-hydroxy-(9S,10S)-epoxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450551", "l": "AUF1 binds translation and heat shock proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54861", "l": "(2E)-geranial + H(+) + NADPH + O2 => (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204813", "l": "Interaction of Tie2 and Grb14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71382", "l": "D-aspartate(out) + H(+)(out) + K(+)(in) + 3 Na(+)(out) <=> D-aspartate(in) + H(+)(in) + K(+)(out) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74703", "l": "(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + O2 + reduced [NADPH--hemoprotein reductase] = 5-dehydro-6-demethoxyfumagillol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25266", "l": "2-phenylethylamine + H2O + O2 => 2-phenylacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72691", "l": "Formation of the 43S pre-initiation complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68031", "l": "6,8-dihydroxypurine + H2O + O2 <=> H2O2 + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685162", "l": "SARS-CoV-1 M protein interacts with TRAF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018804", "l": "RAC3 GEFs activate RAC3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78393", "l": "D-mannose(in) => D-mannose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74707", "l": "Binding of IRS to insulin receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102068", "l": "alpha-humulene 10-hydroxylase activity", "d": ["Catalysis of the reaction: (1E,4E,8E)-alpha-humulene + NADPH + O2 + H+ = 10-hydroxy-alpha-humulene + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61146", "l": "H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP => myricetin + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31436", "l": "(2E,6E)-farnesyl diphosphate => (+)-alpha-santalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9861563", "l": "CTLH E3 ligase ubiquitinates LDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49361", "l": "2',2'-dihydroxy-2-oxospirilloxanthin => 2,2'-dioxospirilloxanthin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051978", "l": "lysophospholipid:sodium symporter activity", "d": ["Enables the directed movement of lysophospholipids from one side of a membrane to the other. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009362", "l": "Proteasome degrades PolyUb-RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033509", "l": "USP9X binds Ub:PEX5L (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938314", "l": "ENPPs hydrolyse CoA-SH to PPANT, PAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624952", "l": "Assembly of the retrograde IFT train (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74422", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015383", "l": "sulfate:bicarbonate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449818", "l": "IL13 binds IL13RA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6793666", "l": "MDM2 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52173", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51749", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A => 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13013", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.87", "l": "\"N-acetyllactosaminide 3-alpha-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74068", "l": "ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A => ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428123", "l": "KDSR reduces 3-ketosphingoid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168886", "l": "Hemopexin binds Hemes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848339", "l": "PNPLA5 hydrolyzes TAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38746", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56798", "l": "adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)alamin-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790087", "l": "HVEM induses BTLA phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13316", "l": "H2O + O2 + sarcosine <=> formaldehyde + glycine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74733", "l": "7,4'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine => rhamnetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.8.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64817", "l": "5-aminolevulinate(in) => 5-aminolevulinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452097", "l": "Recruited STAT5 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174967", "l": "NAT2 acetylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78107", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13236", "l": "guanosine + phosphate <=> alpha-D-ribose 1-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700662", "l": "Liganded-ALK dimer binds type I ALK-binding TKIs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28727", "l": "Cu(2+)(in) + H(+)(in) = Cu(2+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75699", "l": "2 glutathione + NAD(+) = glutathione disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42345", "l": "H(+) + NADH + O2 + p-cumate => (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59389", "l": "a fatty acid ester + H2O => a fatty acid + an aliphatic alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34492", "l": "H2O + UDP-N,N'-diacetylbacillosamine => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27303", "l": "7-chloro-L-tryptophan + O2 => 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44496", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine = 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39711", "l": "O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n) = 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}, {"i": "EC:1.5.3.22", "l": "\"coenzyme F420H2 oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42700", "l": "6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + H(+) + methanol", "d": [], "t": []}, {"i": "EC:3.1.1.85", "l": "\"pimeloyl-[acyl-carrier protein] methyl ester esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69156", "l": "spermine dialdehyde = acrolein + N-(4-aminobutyl)-3-aminopropanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54615", "l": "2-oxoglutarate + 3-methylbutanoyl-CoA + O2 <=> 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30873", "l": "2-deoxy-D-ribose 5-phosphate + ADP + H(+) => 2-deoxy-D-ribose + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797553", "l": "Protein 4.1 binds CASK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9695949", "l": "SPHK2 phosphorylates sphingoid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74696", "l": "(+)-exo-beta-bergamotene + O2 + reduced [NADPH--hemoprotein reductase] => (5R)-hydroxy-beta-trans-bergamotene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24197", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) => (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.51", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247843", "l": "secretion of WNT ligands (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78067", "l": "a triacylglycerol + all-trans-retinol = a 1,3-diacylglycerol + an all-trans-retinyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997237", "l": "SH2B proteins bind JAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75639", "l": "(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate = (12S,13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0097243", "l": "flavonoid binding", "d": ["Binding to a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.386", "l": "\"ipsdienol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199014", "l": "CD96 binds PVR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61023", "l": "acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA <=> 5'-deoxyadenosine + 5-(carboxymethyl)uridine(34) in tRNA + CoA + 2 H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59201", "l": "ATP + docosanoate + H(+) => diphosphate + docosanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391211", "l": "Trace amine-associated receptors can bind trace amines (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40331", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5633460", "l": "MDM2 binds TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75013", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35971", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate = diphosphate + fumitremorgin B", "d": [], "t": []}, {"i": "EC:2.5.1.110", "l": "\"12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52922", "l": "16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35695", "l": "(3S)-versiconol acetate + NADP(+) = (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75923", "l": "(S)-4-aminopentanoate + H2O + NAD(+) = 4-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39031", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37035", "l": "H2O + L-2-aminopentanoate + NAD(+) = 2-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788668", "l": "TRMT13 2'-O-methylates adenosine-4 in tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848338", "l": "PNPLA4 hydrolyzes TAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16254", "l": "(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) => H(+) + NADH + phenanthrene-3,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012268", "l": "ME2 tetramer decarboxylates MAL to PYR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018766", "l": "RHOU binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34502", "l": "1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] <=> H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624948", "l": "KIF17 enters the cilium (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17233", "l": "L-fucose = L-fuculose", "d": [], "t": []}, {"i": "EC:5.3.1.25", "l": "\"L-fucose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.104", "l": "\"enoyl-[acyl-carrier-protein] reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0005371", "l": "tricarboxylate secondary active transmembrane transporter activity", "d": ["Enables the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052715", "l": "mannosyl-diinositol phosphorylceramide phospholipase activity", "d": ["Catalysis of the reaction: mannosyl-diinositol phosphorylceramide + H2O = C26-phytoceramide + mannosyldiphosphorylinositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46142", "l": "(22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033991", "l": "aldos-2-ulose dehydratase activity", "d": ["Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O; (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68193", "l": "decanoyl-CoA + phytol => CoA + decanoate phytyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432295", "l": "GPVI binds Fyn and Lyn (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114284", "l": "Release of Cytochrome c from mitochondria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48198", "l": "reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA => H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696482", "l": "CTF1 binds LIFR:JAKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63408", "l": "6-chloropyridine-2,3,5-triol + FADH2 + O2 = 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13905", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.206", "l": "\"lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44895", "l": "an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose <=> an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17458", "l": "[sulfur-carrier protein]-L-cysteine + L-cysteine => [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.102", "l": "\"C-terminal processing peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50502", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein] => acetyl-CoA + N-terminal L-alanyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50661", "l": "3-(3-methylsulfanyl)propylmalate => 2-(2-methylsulfanyl)propylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395364", "l": "LTBP4 binds TGF-Beta-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32836", "l": "4-(trimethylamino)butanoate(in) => 4-(trimethylamino)butanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71663", "l": "a menaquinone + 2 H(+)(out) + succinate = a menaquinol + fumarate + 2 H(+)(in)", "d": [], "t": []}, {"i": "EC:7.1.1.12", "l": "\"succinate dehydrogenase (electrogenic, proton-motive force generating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102211", "l": "unsaturated rhamnogalacturonyl hydrolase activity", "d": ["Catalysis of the reaction: 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose(1-) + H2O = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + alpha-L-rhamnopyranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18202", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470073", "l": "Peroxynitrite enters the bacterium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12580", "l": "H2O + NAD(+) + tauropine = H(+) + NADH + pyruvate + taurine", "d": [], "t": []}, {"i": "EC:1.5.1.23", "l": "\"tauropine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664588", "l": "ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60785", "l": "2-oxoglutarate + gibberellin A24 + O2 => CO2 + gibberellin A25 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11297", "l": "2,5-dioxopentanoate + H2O + NADP(+) => 2-oxoglutarate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54652", "l": "peregrinol diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.174", "l": "\"peregrinol diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18542", "l": "10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine => dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49030", "l": "(-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783492", "l": "TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71070", "l": "L-arginine(in) + L-phenylalanine(out) <=> L-arginine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170120", "l": "Translocation of Cdc25B to the cytoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74475", "l": "(Z)-4'-methoxydehydrocyclopeptine + 2-oxoglutarate + O2 = (-)-4'-methoxycyclopenine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47411", "l": "(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O <=> (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22203", "l": "S-adenosyl-L-methionine + trans-aconitate <=> (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835189", "l": "NCK1 binds PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48484", "l": "a propanoate ester + H2O = an aliphatic alcohol + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2399913", "l": "atRAL binds to RBP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46925", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA => 4-methylpent-2-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983150", "l": "Proteasomal cleavage of substrate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72958", "l": "2 Na(+)(out) + nicotinate(out) <=> 2 Na(+)(in) + nicotinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16622", "l": "dihydrosanguinarine + H(+) + O2 => H2O2 + sanguinarine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659611", "l": "ANO1 inhibitors bind ANO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.15", "l": "\"renin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606682", "l": "MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018593", "l": "4-chlorophenoxyacetate monooxygenase activity", "d": ["Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417896", "l": "P2Y6 receptor can bind to UDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74087", "l": "an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP = ADP + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36258", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63649", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102123", "l": "gibberellin A4 16alpha,17 epoxidase activity", "d": ["Catalysis of the reaction: gibberellin A4 + O2 + H+ + NAD(P)H = 16alpha,17-epoxy gibberellin A4 + H2O + NAD(P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11515", "l": "salicyl alcohol + UDP-alpha-D-glucose <=> H(+) + salicin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17420", "l": "ATP + N-acetyl-D-glucosamine <=> ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21324", "l": "2 H(+) + reduced [rubredoxin] + superoxide = H2O2 + oxidized [rubredoxin]", "d": [], "t": []}, {"i": "EC:1.15.1.2", "l": "\"superoxide reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18148", "l": "ATP + beta-D-fructose <=> ADP + beta-D-fructose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31796", "l": "(+)-(E)-beta-caryophyllene + H2O => (+)-caryolan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48220", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA = (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002466", "l": "Formation of allysine by LOX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022911", "l": "CSPG is secreted (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45297", "l": "a sphingosylphosphocholine + H2O => a sphingoid base + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23006", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26256", "l": "H(+) + isopimara-7,15-dienol + NADPH + O2 <=> 2 H2O + isopimara-7,15-dienal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.-", "l": "\"Other intramolecular oxidoreductases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20073", "l": "D-allo-threonine = acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664940", "l": "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18767", "l": "a 1,2-diacyl-sn-glycerol + a sphingomyelin => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73221", "l": "L-xylopyranose(in) + 2 Na(+)(in) => L-xylopyranose(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63104", "l": "H(+) + ilicicolin A epoxide + NADPH + O2 = 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047301", "l": "valine-3-methyl-2-oxovalerate transaminase activity", "d": ["Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166817", "l": "Cleavage of C3 by C3 convertases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50397", "l": "(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA => 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635854", "l": "GLI2,3 are degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034564", "l": "4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity", "d": ["Catalysis of the reaction: 4,4'-dihydroxy-alpha-methylstilbene + O2 = 4-hydroxybenzaldehyde + 4-hydroxyacetophenone + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653957", "l": "Rag dimer formation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68735", "l": "ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373747", "l": "Phosphorylation of nephrin by FYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928607", "l": "p-EPHs bind VAV2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12945", "l": "2'-hydroxybiphenyl-2-sulfinate + H2O = biphenyl-2-ol + H(+) + sulfite", "d": [], "t": []}, {"i": "EC:3.13.1.3", "l": "\"2'-hydroxybiphenyl-2-sulfinate desulfinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27703", "l": "aldehydo-D-galacturonate => keto-D-tagaturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61960", "l": "a 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z-hexadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78659", "l": "2 O2 + 2 reduced [NADPH--hemoprotein reductase] + silphinene-15-oate = gamma-lactone-2-keto[5.5.5.5]fenestrane + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51890", "l": "2,3,5,6-tetrachloro-1,4-benzoquinone + NADH => 2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52571", "l": "epitestosterone + UDP-alpha-D-glucuronate <=> epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183067", "l": "Localization of CBL:GRB2 to the membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58530", "l": "(16R)-deshydroxymethyl-stemmadenine + formate + NADP(+) => 15alpha-stemmadenine intermediate I + H2O + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442749", "l": "CaMKK autophosphorylates in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12051", "l": "3-oxoadipate + succinyl-CoA <=> 3-oxoadipyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042656", "l": "JUN kinase kinase kinase kinase activity", "d": ["Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617877", "l": "HOXA4 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222376", "l": "NOX2 generates superoxide from oxygen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52918", "l": "16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9842666", "l": "Active LTK phosphorylates IRS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73783", "l": "dimethylallyl diphosphate + tardioxopiperazine A = diphosphate + echinulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683774", "l": "p-T68-CHEK2 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240957", "l": "Formation of PRC2-EZH2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46236", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41751", "l": "3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429955", "l": "CCR4-NOT complex deadenylates mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211968", "l": "CYP2W1 oxidises INDOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0099122", "l": "RNA polymerase II C-terminal domain binding", "d": ["Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851890", "l": "MET phosphorylates SHC1-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14171", "l": "ADP + glutaryl-CoA + phosphate => ATP + CoA + glutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61331", "l": "O2 + parthenolide + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64142", "l": "a fatty acid + L-asparagine => an N-(fatty acyl)-L-asparagine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36875", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8963851", "l": "VD3 dissociates from GC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418456", "l": "cGMP is degraded by PDEs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48670", "l": "20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68976", "l": "glycoursodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10927", "l": "cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide <=> trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10677", "l": "(2R,3S)-3-isopropylmalate => 2-isopropylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19575", "l": "[phosphate](n+1) + ADP => [phosphate](n) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10589", "l": "4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH => 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67843", "l": "a lipid A disaccharide + ATP <=> a lipid IVA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21167", "l": "a carboxylic ester + H2O <=> a carboxylate + an alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41383", "l": "H(+) + NADH + O2 + toluene <=> 4-methylphenol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046988", "l": "asioloorosomucoid beta-1,3-glucuronosyltransferase activity", "d": ["Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031521", "l": "NR1H2,3 binds the APOC2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062063", "l": "BBSome binding", "d": ["Binding to a BBSome complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0019111", "l": "phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13686", "l": "lathosterol + NADP(+) => 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77326", "l": "glyoxylate + N(omega)-methyl-L-arginine <=> 5-(3-methylguanidino)-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72261", "l": "3-O-methyl-L-dopa + H(+) + S-adenosyl-L-homocysteine => L-dopa + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036189", "l": "abieta-7,13-diene hydroxylase activity", "d": ["Catalysis of the reaction: abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9906042", "l": "TTC19 clears UQCRFS1 fragments from Complex III (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23779", "l": "ATP + L-aspartate <=> 4-phospho-L-aspartate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688838", "l": "RIPK3 binds STUB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798528", "l": "S100A8:S100A9 binds Mn2+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48596", "l": "1,2-didecanoylglycerol + H2O = decanoate + decanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29536", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70537", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+) => GDP-beta-L-fucose + L-seryl-[EGF-like domain protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38196", "l": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.48", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110215", "l": "Cleavage of uracil by UNG glycosylase (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63963", "l": "abscisate(out) + ATP + H2O <=> abscisate(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617668", "l": "HOXB3 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72103", "l": "Formation of pre-mRNPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858643", "l": "MITF-M dimer binds the CCNB1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0008422", "l": "beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32411", "l": "(1R,2R,4S)-isodihydrocarveol + NAD(+) = (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678925", "l": "NR3C1 binds NR3C1 agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299318", "l": "Activation of TASK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27575", "l": "(3R)-piperidine-3-carboxamide + H2O => (3R)-piperidine-3-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72490", "l": "citrate(out) + phosphoenolpyruvate(in) <=> citrate(in) + phosphoenolpyruvate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70668", "l": "a fatty acyl-[ACP] + L-lysyl-[protein] => H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26345", "l": "L-galactonate + NADP(+) = aldehydo-D-galacturonate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.365", "l": "\"D-galacturonate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73519", "l": "dUTP(out) + UTP(in) = dUTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73711", "l": "ATP(in) + UTP(out) = ATP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13854", "l": "4-methylene-L-glutamate + ATP + NH4(+) => 4-methylene-L-glutamine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "61.503765032644353", "identifiers": [{"i": "GO:0004553", "l": "hydrolase activity, hydrolyzing O-glycosyl compounds", "d": ["Catalysis of the hydrolysis of any O-glycosyl bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74571", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] = N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51180", "l": "cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9825783", "l": "p-S207 KARS1 dimer translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47140", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244402", "l": "botB:SYT:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482775", "l": "Release of (inferred) platelet cytosolic components (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877153", "l": "STARD7 binds PC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47197", "l": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11436", "l": "4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O", "d": [], "t": []}, {"i": "EC:7.1.1.9", "l": "\"cytochrome-c oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78452", "l": "a globoside Gb3Cer + H2O => a fatty acid + a lysoGb3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51058", "l": "AH2 + androsta-1,4-diene-3,17-dione => A + androst-4-ene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60617", "l": "N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine => ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14078", "l": "3-oxopropanoate + L-alanine => beta-alanine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38619", "l": "nicotinate beta-D-ribonucleotide + phenol = H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside", "d": [], "t": []}, {"i": "EC:2.4.2.55", "l": "\"nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15063", "l": "2 a Fe(III)-siderophore + NADH => 2 a Fe(II)-siderophore + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52080", "l": "12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871373", "l": "BMX phosphorylates RUFY1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47450", "l": "(2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36966", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434650", "l": "MATEs mediate extrusion of xenobiotics (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265862", "l": "Association of RAD51 with BRCA2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74155", "l": "H2O + oxidized 2[4Fe-4S]-[ferredoxin] + sarcosine = formaldehyde + glycine + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173709", "l": "C7 binds C5b:C6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52778", "l": "camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase] => 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12363", "l": "(2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine <=> 13-(2-methylcrotonoyloxy)lupanine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.99.-", "l": "\"Transferring other nitrogenous groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24562", "l": "CoA + O-acetyl-L-serine => acetyl-CoA + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382058", "l": "Nck binds to the active PDGF receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375138", "l": "CDO binds BOC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19036", "l": "an N-acyl-D-glucosamine <=> an N-acyl-D-mannosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33165", "l": "beta-nicotinamide D-riboside(out) => beta-nicotinamide D-riboside(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76795", "l": "2-aminopropan-1-ol + H2O + NAD(+) = H(+) + hydroxyacetone + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71416", "l": "3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in) => 3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848370", "l": "IL18 binds IL18R1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688456", "l": "MLKL binds FLOT1, FLOT2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50138", "l": "(9Z)-octadecenoate + ethanol + H(+) => ethyl (9Z)-octadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784189", "l": "JAKs bind LIFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396009", "l": "STING binds c-di-GMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55463", "l": "11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390329", "l": "Dephosphorylation of AKT by PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948230", "l": "P3HB binds 4-Hyp-collagen propeptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8984001", "l": "IL35 binds IL27RA:IL12RB2 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391935", "l": "DP1 receptor can bind PGD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047492", "l": "xanthan lyase activity", "d": ["Catalysis of the reaction: xanthan = oligosaccharide with 4-deoxy-alpha-L-threo-hex-4-enuronosyl end + pyruvylate mannose. This reaction is the eliminative cleavage of the terminal beta-D-mannosyl-beta-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-alpha-L-threo-hex-4-enuronosyl group at the terminus of the side-chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047521", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity", "d": ["Catalysis of the reaction: 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14617", "l": "CoA + glutathione + NADP(+) = CoA-glutathione + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.8.1.10", "l": "\"CoA-glutathione reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70088", "l": "methanol + o-quinone methide => hydroxyclavatol methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168459", "l": "Lyn activates ERK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377640", "l": "Autophosphorylation of SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11586", "l": "D-ornithine => L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724099", "l": "ALK mutants:p-3Y SHC binds GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69142", "l": "Recruitment of Dna2 endonuclease (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170674", "l": "Dissociation of the Gi alpha:G olf complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33070", "l": "(4R)-hydroxysphinganine 1-phosphate + H2O <=> (4R)-hydroxysphinganine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14289", "l": "a dicarboxylate + ATP + CoA = AMP + diphosphate + omega-dicarboxyl-CoA", "d": [], "t": []}, {"i": "EC:6.2.1.23", "l": "\"dicarboxylate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17202", "l": "2-dehydro-3-deoxy-L-arabinonate => 2,5-dioxopentanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106026", "l": "Gly-tRNA(Ala) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Gly-tRNA(Ala)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38174", "l": "hexadecane-1,2-diol + hexadecanoyl-CoA <=> 2-hydroxyhexadecyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190245", "l": "FGFR1b binds to FGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67078", "l": "H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine => L-histidyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761812", "l": "AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668605", "l": "RAC2:GTP binds NOX2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45594", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25719", "l": "H(+) + N,N-dihydroxy-L-trihomomethionine = (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050163", "l": "oxaloacetate tautomerase activity", "d": ["Catalysis of the reaction: oxaloacetate = <stereo>enol</stereo>-oxaloacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44928", "l": "2-oxoheptanedioate + acetyl-CoA + H2O = (R)-trihomocitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683831", "l": "CCDC59 binds TTF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.44", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021952", "l": "RBFOX1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9854463", "l": "SIRT3 deacetylates AcK-IDH2 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5612510", "l": "Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9824888", "l": "OPTN, TBK1 bind ubiquitinated MOM proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204813", "l": "Interaction of Tie2 and Grb14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390909", "l": "HRH2 binds hist (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9824995", "l": "GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033943", "l": "galactan 1,3-beta-galactosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74319", "l": "O-acetyl-(R)-carnitine(in) = O-acetyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10798", "l": "albendazole S-oxide + H2O + NADP(+) => albendazole + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74718", "l": "Internalisation of the insulin receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65702", "l": "cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32666", "l": "5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine <=> (3R)-5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23340", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate = D-arabinose + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.2.23", "l": "\"3-deoxy-D-manno-octulosonate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134914", "l": "Beta-catenin migrates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250488", "l": "GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33703", "l": "(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55837", "l": "calcitriol + UDP-alpha-D-glucuronate => calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195304", "l": "Association of beta-catenin with the destruction complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42532", "l": "uridine(55) in tRNA = pseudouridine(55) in tRNA", "d": [], "t": []}, {"i": "EC:5.4.99.25", "l": "\"tRNA pseudouridine(55) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60527", "l": "5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67633", "l": "a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin] => a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58278", "l": "cyclic hexaadenylate + 6 diphosphate => 6 ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046714", "l": "borate binding", "d": ["Binding to borate, the anion (BO3)3-."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51900", "l": "H2O + N(1)-acetylspermidine = acetate + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42432", "l": "3-hydroxy-cis,cis-muconate = maleylacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35368", "l": "(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH => isoheptadecanoyl-coA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218814", "l": "PAK2 autophorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62206", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + propanal => 1-propanol + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13676", "l": "[protein-PII]-L-tyrosine + UTP <=> [protein-PII]-uridylyl-L-tyrosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24451", "l": "enterobactin + UDP-alpha-D-glucose <=> monoglucosyl-enterobactin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47515", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH <=> isocholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.11", "l": "\"pterin deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30691", "l": "H2O2 + methanol = formaldehyde + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004400", "l": "histidinol-phosphate transaminase activity", "d": ["Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296127", "l": "Activation of voltage gated Potassium channels (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47584", "l": "a ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GT1c (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65013", "l": "decanoyl-AMP + holo-[ACP] => AMP + decanoyl-[ACP] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69329", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate => 5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168285", "l": "Clathrin-Mediated Pit Formation And Endocytosis Of The Influenza Virion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033219", "l": "urea binding", "d": ["Binding to urea, a water-soluble carboxamide with the structure H2N-CO-NH2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382057", "l": "Release of novel PDGFs as latent factors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44876", "l": "a 1,3-diacylglycerol + H2O = a 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29509", "l": "(-)-alpha-gurjunene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43937", "l": "androst-5-ene-3,17-dione => androst-4-ene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70692", "l": "ornithine => putrescine + CO2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68629", "l": "phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0015217", "l": "ADP transmembrane transporter activity", "d": ["Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909724", "l": "Recruitment of IFNAR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13770", "l": "glycerol + NAD(+) => dihydroxyacetone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36679", "l": "dTDP-6-deoxy-alpha-D-allose + NAD(+) = dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66265", "l": "ATP + H(+) + nonanoate => diphosphate + nonanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43891", "l": "[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine <=> [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848250", "l": "ACBD6 binds LCFA-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51296", "l": "a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(R)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67052", "l": "AH2 + asnovolin J + O2 = A + asnovolin A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.20", "l": "\"methylenetetrahydrofolate reductase [NAD(P)H]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53597", "l": "1-octadecanoyl-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77725", "l": "a neolactoside V(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70061", "l": "a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002196", "l": "Ser-tRNA(Ala) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60964", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose = (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9646685", "l": "Aggresome dissociates from dynein and microtubule (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76825", "l": "formaldehyde + H(+) + NADH + NH4(+) => H2O + methylamine + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15018", "l": "a phosphate monoester + H2O => an alcohol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53277", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] => 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33408", "l": "ATP + glycine + H(+) => diphosphate + glycyl-5'-AMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76750", "l": "hexadecane + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-hexadecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23574", "l": "3 CO2 + 4 CoA + phlorisovalerophenone => 3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20305", "l": "4-hydroxybenzaldehyde + H2O + NAD(+) = 4-hydroxybenzoate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.64", "l": "\"4-hydroxybenzaldehyde dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74528", "l": "H(+) + N(6),N(6)-dimethyl-L-lysine => CO2 + N,N-dimethyl-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18322", "l": "2-oxoglutarate + L-leucine => 4-methyl-2-oxopentanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791056", "l": "Expression of CCL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53868", "l": "2 H(+) + NADH + O2 + phenazine-1-carboxylate = 1-hydroxyphenazine + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70647", "l": "D-serine(out) + H(+)(out) = D-serine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19337", "l": "2 hydroxylamine + 2 NAD(+) = 2 H(+) + hyponitrous acid + 2 NADH", "d": [], "t": []}, {"i": "EC:1.7.1.5", "l": "\"hyponitrite reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48412", "l": "a globoside IV3GalNAc-Gb4Cer + H2O = a globoside Gb4Cer + N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112604", "l": "Phosphorylated STATs are released (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37182", "l": "(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate <=> (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047382", "l": "methylphosphothioglycerate phosphatase activity", "d": ["Catalysis of the reaction: S-methyl-3-phospho-1-thio-D-glycerate + H2O = S-methyl-1-thio-D-glycerate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65224", "l": "(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) = H(+) + NADPH + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72697", "l": "Start codon recognition (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73320", "l": "(2R,3S)-piscidate + (E)-4-coumaroyl-CoA => cimicifugate K + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75338", "l": "bromide(in) + chloride(out) <=> bromide(out) + chloride(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799761", "l": "TP53 binds PPP1R13L (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77589", "l": "Recognition of AAUAAA sequence by CPSF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851018", "l": "BTN2A1 binds DC-SIGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60513", "l": "a guanosine in miRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419645", "l": "Dimerization of LIMK1 by Hsp90 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26502", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose = 2 H(+) + ternatin C5 + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047908", "l": "fusarinine-C ornithinesterase activity", "d": ["Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0048185", "l": "activin binding", "d": ["Binding to activin, a dimer of inhibin-beta subunits."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38012", "l": "chlorophyll a + H2O => chlorophyllide a + H(+) + phytol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64993", "l": "acetyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.302", "l": "\"hydroxycinnamoyl-CoA:5-hydroxyanthranilate N-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013108", "l": "GDIs block activation of RHOC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32079", "l": "(13E)-labda-7,13-dien-15-yl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692539", "l": "HRH1 binds HRH1 inverse agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51360", "l": "H2O + N-(9Z-octadecenoyl)-L-leucine = (9Z)-octadecenoate + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35083", "l": "diacetylchitobiose-6'-phosphate + H2O = acetate + N'-monoacetylchitobiose-6'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.96", "l": "\"4-aminobutyrate--pyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9858647", "l": "HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13398", "l": "6-oxohexanoate + H2O + NADP(+) => 2 H(+) + hexanedioate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78703", "l": "4-(hydroxy(methyl)phosphoryl)-2-oxobutanoate + L-glutamate = 2-oxoglutarate + L-phosphinothricin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24170", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62734", "l": "(+)-isomalbrancheamide D + FADH2 => (+)-isomalbrancheamide B + bromide + FAD + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806610", "l": "Keratin filament formation (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265456", "l": "NPC1L1 binds ezetimibe (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046025", "l": "precorrin-6Y C5,15-methyltransferase (decarboxylating) activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34984", "l": "sulfate(in) => sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27791", "l": "2-all-trans-octaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804741", "l": "MDM2 forms homo- or heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41798", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25984", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31050", "l": "(S)-2-methyl-3-oxopropanoate + CoA + NAD(+) <=> CO2 + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28064", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+) => alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51819", "l": "ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) <=> AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18634", "l": "2 ATP + H2O + hydrogencarbonate + L-glutamine => 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21602", "l": "CoA + N-benzoylanthranilate => anthranilate + benzoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18370", "l": "O2 + sn-glycerol 3-phosphate => dihydroxyacetone phosphate + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41300", "l": "H2O + N-(9Z-octadecenoyl)-sphing-4-enine => (9Z)-octadecenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43874", "l": "3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate => 3-oxochol-4-en-22-oate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0018030", "l": "peptidyl-lysine N6-myristoyltransferase activity", "d": ["Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.17", "l": "\"lysozyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640480", "l": "E2 enzyme UBE2N:UBE2V1 binds ubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24925", "l": "2-oxobutanoate + NH4(+) => L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49745", "l": "deoxyviolaceinate + H(+) + O2 => CO2 + deoxyviolacein + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022378", "l": "ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56766", "l": "12-epi-fischerindole G + CO2 + H2O + succinate => 12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052577", "l": "germacrene-D synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-germacrene D + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12585", "l": "16alpha-hydroxyprogesterone => 16,17-didehydroprogesterone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102782", "l": "cholestanol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + epidihydrocholesterin + O2 + NADPH = (22alpha)-hydroxy-cholestanol + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9844587", "l": "GAL3ST1 transfers sulfate to GalCer,LacCer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47752", "l": "5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine = 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65935", "l": "3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine <=> 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47181", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) => (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038117", "l": "C-C motif chemokine 19 receptor activity", "d": ["Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23786", "l": "(S)-1-pyrroline-5-carboxylate + a quinol + H(+) => a quinone + L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45517", "l": "phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41732", "l": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.1", "l": "\"glycogen phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19442", "l": "benzene-1,2,4-triol + O2 => 3-hydroxy-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11802", "l": "AMP + beta-nicotinamide D-ribonucleotide + 2 H(+) => H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.46", "l": "\"galactan 5-O-arabinofuranosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.31", "l": "\"D-tagatose 3-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218847", "l": "PAK2 binds NCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52374", "l": "17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55517", "l": "11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] => 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237160", "l": "MTA is cleaved and phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20561", "l": "3-hydroxypyruvate + H(+) = CO2 + glycolaldehyde", "d": [], "t": []}, {"i": "EC:4.1.1.40", "l": "\"hydroxypyruvate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23210", "l": "(2E)-glutaconyl-CoA + acetate => acetyl-CoA + trans-glutaconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.201", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29023", "l": "H(+)(in) + L-fucose(in) = H(+)(out) + L-fucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027274", "l": "EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 binds SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68061", "l": "a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68752", "l": "alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74676", "l": "AH2 + archaeol + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaeol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18022", "l": "a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GD1a (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694421", "l": "PP6 dephosphorylates SEC24 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77771", "l": "13-cis-retinol + a fatty acyl-CoA = 13-cis-retinyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18490", "l": "cyanate + H(+) + hydrogencarbonate => carbamate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61990", "l": "5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067659", "l": "Assembly of hexameric IL-6 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22586", "l": "Fe(2+) + protoporphyrin IX => 2 H(+) + heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36544", "l": "H2O + mycothiol S-conjugate => 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0031883", "l": "taste receptor binding", "d": ["Binding to a taste receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.214", "l": "\"C7-cyclitol 7-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797961", "l": "CHDH oxidises Cho to BETALD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43936", "l": "androst-5-ene-3,17-dione = androst-4-ene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78999", "l": "3-aminoavenalumate + ATP + H(+) + nitrite = 3-diazoavenalumate + AMP + diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60289", "l": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033251", "l": "cephalosporinase activity", "d": ["Catalysis of the reaction: a cephalosporin + H2O = a substituted beta-amino acid derivative of the cephalosporin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0042903", "l": "tubulin deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate."], "t": []}, {"i": "REACT:R-HSA-5618331", "l": "HDAC6 deacetylates microtubules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70371", "l": "3-oxosphinganine + decanoyl-CoA = CoA + H(+) + N-decanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56304", "l": "ATP + H2O + rifampicin = 21-phosphorifampicin + AMP + 2 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:2.7.9.6", "l": "\"rifampicin phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15250", "l": "3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose => 1-O-galloyl-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668395", "l": "CHMP7 binds CC2D1B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57313", "l": "H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine => cytidine 5'-diphosphoramidate + H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730856", "l": "Autophosphorylation of PAK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36323", "l": "(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH = (9Z)-octadecen-1-ol + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.26", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74007", "l": "dimethylallyl diphosphate + H2O + yaequinolone E = [(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42334", "l": "ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate => ATP + L-glutamate + oxidized coenzyme F420-2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043756", "l": "adenosylcobinamide hydrolase activity", "d": ["Catalysis of the reaction: adenosylcobinamide + H2O = (R)-1-aminopropan-2-ol + adenosylcobyrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2509831", "l": "ITPA hydrolyses XTP to XMP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37641", "l": "1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43308", "l": "1-hexadecanoyl-sn-glycerol + ATP = 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47261", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67173", "l": "O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] => formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47126", "l": "H2O + N-hexacosanoylglycine => glycine + hexacosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70659", "l": "H(+)(in) + N,N-dimethylglycine(in) = H(+)(out) + N,N-dimethylglycine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.8", "l": "\"protein-secreting ATPase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404142", "l": "atROL binds RBP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47603", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GM4 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59544", "l": "N,N'-diacetylchitobiose + O2 = H2O2 + N,N'-diacetylchitobiono-1,5-lactone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378975", "l": "Follitropin is a heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51066", "l": "adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate => 3'-phosphoadenylyl sulfate + lithocholate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22254", "l": "a globoside Gb4Cer (d18:1(4E)) + H(+) + UDP => a globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57970", "l": "8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0141051", "l": "histone H4K deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine + H2O = histone H4 L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone H4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22682", "l": "dUTP + NH4(+) => dCTP + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63738", "l": "2-phenylethanol + NADP(+) => 2-phenylacetaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74902", "l": "(2E)-2-butenoate + ATP + holo-[ACP] <=> (2E)-butenoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37371", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O = a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20140", "l": "10-deacetylbaccatin III + acetyl-CoA <=> baccatin III + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13543", "l": "H(+) + sulfate + sulfur + thiosulfate => H2O + tetrathionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9793472", "l": "RIPK3 binds p-S9-PRKN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73809", "l": "N(7)-methyl-GDP + S-adenosyl-L-homocysteine => GDP + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34007", "l": "7-dehydrodesmosterol + S-adenosyl-L-methionine = 5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62800", "l": "2 7-demethylsiderin + NADPH + O2 = 2 H2O + NADP(+) + orlandin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14142", "l": "AMP + glutathione disulfide + 2 H(+) + sulfite => adenosine 5'-phosphosulfate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38859", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose = bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31453", "l": "a cardiolipin + glycerol => 2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72239", "l": "estrone 3-sulfate(out) + L-glutamate(in) = estrone 3-sulfate(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382056", "l": "Crk binds to the active PDGF receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34211", "l": "ecgonine methyl ester + NADP(+) = ecgonone methyl ester + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.334", "l": "\"methylecgonone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74716", "l": "Insulin binds the insulin receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59742", "l": "CoA + S-octadecanoyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174070", "l": "Association of Cdh1 with the APC/C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202510", "l": "Activation of TAK1-TAB2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-217255", "l": "FMO1:FAD N-oxidises TAM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15806", "l": "(7R,8S)-7,8-diammoniononanoate + ATP + CO2 => (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15539", "l": "3-sulfopyruvate + H(+) + NADPH => (2R)-3-sulfolactate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47940", "l": "a ganglioside GM2 (d18:1(4E)) + H2O = a ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72151", "l": "estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061655", "l": "Pup conjugating enzyme activity", "d": ["Isoenergetic transfer of Pup from one protein to another via the reaction X-Pup + Y = Y-Pup + X, where both the X-Pup and Y-Pup linkages are thioester bonds between the C-terminal amino acid of Pup and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63826", "l": "aspulvinone E + H2O => 2 3-(4-hydroxyphenyl)pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48298", "l": "glycerol + H(+) + prostaglandin E2 => H2O + prostaglandin E2 1-glyceryl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3791319", "l": "NID1 degradation by MMP19 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019001", "l": "guanyl nucleotide binding", "d": ["Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate."], "t": []}, {"i": "REACT:R-HSA-156909", "l": "eEF1A complexes with GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56185", "l": "a globoside Gb4Cer + UDP-alpha-D-galactose => a globoside NOR1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53737", "l": "a 2-halobenzoate + H(+) + NADH + O2 => a halide anion + catechol + CO2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65319", "l": "2-oxoglutarate + chrodrimanin H + O2 <=> chrodrimanin E + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58600", "l": "2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47659", "l": "acetyl-CoA + L-methionine sulfone <=> CoA + H(+) + N-acetyl-L-methionine sulfone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855161", "l": "I(1,3,4,5,6)P5 transports from the nucleus to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33912", "l": "an N-alkylglycine + H2O + O2 => an alkylamine + glyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59804", "l": "L-phenylalanine = D-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0004033", "l": "aldo-keto reductase (NADPH) activity", "d": ["Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193665", "l": "MYD88 dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390649", "l": "CHRM1,3,5 bind acetylcholine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32939", "l": "a 1,2-diacyl-sn-glycerol + CDP-choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37936", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73618", "l": "CTP(out) + dCMP(in) <=> CTP(in) + dCMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62085", "l": "ADP + D-glucosamine => AMP + D-glucosamine 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953111", "l": "E2F6 binds TFDP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28080", "l": "H(+) + NADH + phosphonoacetaldehyde => 2-hydroxyethylphosphonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23119", "l": "4-hydroxybenzoate + ATP + CoA <=> 4-hydroxybenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017988", "l": "CRH gene expression is repressed by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16796", "l": "H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine <=> (R)-4'-phosphopantetheine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607753", "l": "CARD9 oligomerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69301", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate => benzyl isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830882", "l": "Nascent G signal peptide is cleaved at ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018736", "l": "6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69082", "l": "3,4-dihydroxyphenylacetate + 2 H(+) + NADH => 3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162193", "l": "COQ3 methylates DHDB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.105", "l": "\"rhomboid protease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448958", "l": "Nuclear translocation of p38 MAPK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76364", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(out) => n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78673", "l": "3-oxododecanoyl-CoA + H(+) + NADH => (3R)-3-hydroxydodecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70977", "l": "3-sulfino-L-alanine(in) + L-aspartate(out) => 3-sulfino-L-alanine(out) + L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754964", "l": "ADA deamidates RBV (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16564", "l": "H2O + squalene <=> hopan-22-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30188", "l": "(S)-dihydroorotate + a quinone => a quinol + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986972", "l": "IL24 binds IL20RA:JAK1:IL20RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69258", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => H2O + progoitrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983147", "l": "Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.81", "l": "\"streptogrisin B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52010", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047200", "l": "tetrahydrodipicolinate N-acetyltransferase activity", "d": ["Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = L-2-acetamido-6-oxopimelate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32660", "l": "(6E)-8-hydroxygeraniol + 2 NADP(+) => (6E)-8-oxogeranial + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20624", "l": "ATP + H2O + Zn(2+)(in) <=> ADP + H(+) + phosphate + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14167", "l": "CoA + H(+) + N-acetyl-L-aspartate => acetyl-CoA + L-aspartate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102696", "l": "cis-zeatin UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin = H+ + 9-(alpha-D-glucosyl)-cis-zeatin + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.66", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71852", "l": "glycocholate(out) => glycocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16346", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78439", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1,2-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46422", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39194", "l": "(2E)-docosenoyl-CoA + H(+) + NADPH <=> docosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24162", "l": "D-galacto-hexodialdose + H2O2 => D-galactose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139919", "l": "Translocation of BIM to mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78990", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> cattleyene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76916", "l": "(1S)-3-methyl-cyclohexylamine + H2O + NADP(+) => 3-methylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517444", "l": "TAT aminates HPP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44784", "l": "2-demethylmenaquinol-10 + S-adenosyl-L-methionine = H(+) + menaquinol-10 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46856", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35766", "l": "8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68098", "l": "a 3'-end ribonucleotide-RNA + a 5'-end 5'-phospho-ribonucleoside-RNA + H(+) => a ribonucleotidyl-ribonucleotide-RNA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52618", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+) => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64363", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 <=> (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610735", "l": "NUMB binds ITCH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35087", "l": "H2O + N'-monoacetylchitobiose-6'-phosphate = D-glucosamine + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18868", "l": "2-methylpropanoyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] <=> CoA + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30446", "l": "2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc <=> 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50969", "l": "adenosine(37) in tRNA(Ala) + H(+) + H2O => inosine(37) in tRNA(Ala) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43072", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.47", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032795", "l": "heterotrimeric G-protein binding", "d": ["Binding to a heterotrimeric G-protein."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50879", "l": "a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH <=> a hydroxy polyunsaturated fatty acid + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813740", "l": "GDE1 hydrolyzes GroPIns (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138432", "l": "DVL2 is phosphorylated by PKC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047724", "l": "inosine nucleosidase activity", "d": ["Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9011595", "l": "GSTZ1 dimer dehalogenates DCA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38123", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57504", "l": "3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19996", "l": "[thioredoxin]-disulfide + H2O + L-methionine <=> [thioredoxin]-dithiol + L-methionine (S)-S-oxide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471621", "l": "Endostatin degradation by cathepsins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56082", "l": "[Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+) => [Rab1 protein]-L-serine + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0001671", "l": "ATPase activator activity", "d": ["Binds to and increases the activity of an ATP hydrolysis activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58855", "l": "(6E)-8-oxogeraniol + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65934", "l": "3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14927", "l": "D-mannose 6-phosphate + H(+) + NADPH => D-mannitol 1-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29007", "l": "H(+)(in) + Mn(2+)(in) = H(+)(out) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877281", "l": "PIAS1 binds p-STAT1 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19287", "l": "a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol => a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36197", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17489", "l": "H(+) + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.7", "l": "\"phthalate 4,5-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20548", "l": "H(+) + L-kynurenine + NADPH + O2 <=> 3-hydroxy-L-kynurenine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109639", "l": "Formation of the closed pre-initiation complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63855", "l": "dodecanoate + O2 <=> (2R)-2-hydroperoxydodecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72913", "l": "atranorin + S-adenosyl-L-homocysteine => proatranorin III + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54788", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20344", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose <=> 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45202", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18657", "l": "(R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37454", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52229", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + biliverdin IXbeta + CO + Fe(2+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34800", "l": "2,3-didehydroadipoyl-CoA + acetyl-CoA => 3-oxo-5,6-didehydrosuberyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22151", "l": "a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] <=> a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40007", "l": "(+)-copalyl diphosphate + H2O = (+)-copalol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674018", "l": "BRAP binds RAS:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24661", "l": "H(+) + L-arginine + NADPH + O2 => H2O + N(omega)-hydroxy-L-arginine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77066", "l": "1-cyclohexylethanamine + H2O + NADP(+) <=> 1-cyclohexylethanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77475", "l": "acetyl-CoA + tetrahydroanabasine = ammodendrine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30630", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) <=> (2S)-2-acetolactate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50572", "l": "acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674558", "l": "p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14611", "l": "H(+) + keto-L-sorbose + NADPH => D-sorbitol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21597", "l": "L-serine + NADP(+) => 2-aminomalonate semialdehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0050220", "l": "prostaglandin-E synthase activity", "d": ["Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68169", "l": "N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375131", "l": "Basigin binds CD98 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56605", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46973", "l": "A + dihydrobisanhydrobacterioruberin => AH2 + bisanhydrobacterioruberin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54958", "l": "AMP + diphosphate + OPC-6-CoA => ATP + CoA + OPC-6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50308", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62965", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose => alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102740", "l": "theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity", "d": ["Catalysis of the reaction: theobromine + S-adenosyl-L-methionine = H+ + caffeine + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60620", "l": "N-hexanoyl-sphing-4-enine-1-phosphocholine = choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865320", "l": "CBFB binds RUNX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983144", "l": "Transport of Antigen peptide in to ER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114440", "l": "Dissociation of DIABLO:XIAP from the apoptosome complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68350", "l": "diphosphate + pppA(2'-5')pG => ATP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57903", "l": "2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 <=> adenosine in U6 snRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033899", "l": "ribonuclease U2 activity", "d": ["Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029460", "l": "PAK1 phosphorylates LIMK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813740", "l": "GDE1 hydrolyzes GroPIns (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220967", "l": "p-NICD1 PEST domain mutants do not bind FBXW7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42719", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate <=> (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33372", "l": "alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] => alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161282", "l": "Elastic fibres bind associated proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102246", "l": "6-amino-6-deoxyfutalosine hydrolase activity", "d": ["Catalysis of the reaction: aminodeoxyfutalosinate + H2O = dehypoxanthine futalosine + adenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19191", "l": "CO2 + N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] => H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031755", "l": "Edg-2 lysophosphatidic acid receptor binding", "d": ["Binding to an Edg-2 lysophosphatidic acid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26129", "l": "(+)-copalyl diphosphate => diphosphate + isopimara-7,15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76330", "l": "L-aspartate(in) + L-phenylalanine(out) <=> L-aspartate(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35111", "l": "2-dehydro-L-idonate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.346", "l": "\"2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69828", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36024", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18348", "l": "a cis-3-alkyl-4-alkyloxetan-2-one <=> a cis-alkene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56810", "l": "adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate => ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168888", "l": "Alpha1-Microglobulin binds heme (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672158", "l": "GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74561", "l": "aldosterone hemiacetal => aldosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73577", "l": "CAD hexamer transforms L-Gln to CAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22115", "l": "isoxazolin-5-one + O-acetyl-L-serine <=> 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68117", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol => a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034039", "l": "8-oxo-7,8-dihydroguanine DNA N-glycosylase activity", "d": ["Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69120", "l": "glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990380", "l": "K48-linked deubiquitinase activity", "d": ["Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022405", "l": "ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47867", "l": "1,2,3-trioctanoylglycerol + H2O <=> dioctanoylglycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71113", "l": "L-phenylalanine(in) + S-methylmercury-L-cysteine(out) => L-phenylalanine(out) + S-methylmercury-L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18043", "l": "8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203946", "l": "PDK isozymes phosphorylate PDHC subunit E1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.92", "l": "\"oxaloglycolate reductase (decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031530", "l": "gonadotropin-releasing hormone receptor binding", "d": ["Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804762", "l": "TP53 forms homotetramers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73329", "l": "cimicifugate J + CoA => (2R,3S)-piscidate + (E)-sinapoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20262", "l": "3,5,7-trioxododecanoyl-CoA => CO2 + CoA + olivetol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51536", "l": "L-tyrosyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-L-tyrosyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690701", "l": "SHP1 binds p-CD22 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14861", "l": "(S)-dihydroorotate + NADP(+) = H(+) + NADPH + orotate", "d": [], "t": []}, {"i": "EC:1.3.1.15", "l": "\"dihydroorotate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853793", "l": "p-5Y-RET complexes bind GRB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13606", "l": "2 L-ascorbate + O2 => 2 H2O + 2 L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53186", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877918", "l": "RUNX2:MAF complex binds the BGLAP gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783880", "l": "PIPOX oxidises PPCA to P6C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26320", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate <=> 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389762", "l": "Phosphorylation of PD-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60037", "l": "H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate => 3-hydroxy-3-methylhexanoate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429767", "l": "Passive I- efflux mediated by SLC5A8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23508", "l": "(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate", "d": [], "t": []}, {"i": "EC:3.5.1.93", "l": "\"glutaryl-7-aminocephalosporanic-acid acylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9770119", "l": "Formation of the Spliceosomal E complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45665", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682992", "l": "KDM4A,B bind H4K20Me2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54855", "l": "H(+) + heptan-4-one + NADPH + O2 <=> H2O + NADP(+) + propyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13733", "l": "an n-alkanal + NAD(+) = an alk-2-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858475", "l": "ppDVL recruits RAC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44948", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O = 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.267", "l": "\"flavonoid 3',5'-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0033695", "l": "oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule."], "t": []}, {"i": "EC:1.17.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44240", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730843", "l": "Phosphorylation of LAT by p-SYK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56638", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30256", "l": "2 a ubiquinol + O2 => 2 a ubiquinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42067", "l": "ATP + GTP <=> 2',3'-cGAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31685", "l": "(-)-solanapyrone A => prosolanapyrone III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392513", "l": "Rap1 signal termination by Rap1GAPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52911", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + O2 <=> 3-dimethylallyl-4-hydroxymandelate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31036", "l": "arabidiol => (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730886", "l": "Phosphorylation of SHC by SYK kinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332359", "l": "Active calmodulin binds CAMK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42944", "l": "cytidine(40) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38512", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21646", "l": "ADP + H(+) + sn-glycerol 3-phosphate => ATP + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052759", "l": "coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity", "d": ["Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex + H- = trinitrophenol dihydride Meisenheimer complex (aci form). Coenzyme F420 supplies the hydride (H-) in the reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40355", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19698", "l": "11-cis-retinyl hexadecanoate + H2O => 11-cis-retinol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13238", "l": "D-fructose 6-phosphate + L-glutamine => D-glucosamine 6-phosphate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051566", "l": "anthocyanidin-3-glucoside rhamnosyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17772", "l": "choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67821", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43169", "l": "adenosine(34) in tRNA + H(+) + H2O => inosine(34) in tRNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938108", "l": "SERPINB13 binds cathepsin L (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047826", "l": "D-lysine 5,6-aminomutase activity", "d": ["Catalysis of the reaction: D-lysine = (2R,5S)-2,5-diaminohexanoate and (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.92", "l": "\"peptidoglycan beta-N-acetylmuramidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60001", "l": "hydroxymethylphosphonate + O2 => formate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0004354", "l": "glutamate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67477", "l": "dimethylallyl diphosphate + L-glutamate => diphosphate + prekainate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33816", "l": "CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168638", "l": "Activated IKK phosphorylates I-kappaB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29974", "l": "2'-deoxyinosine(in) + H(+)(in) <=> 2'-deoxyinosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51234", "l": "2-glyceryl-prostaglandin D2 => 2-glyceryl-prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9839358", "l": "Endocytosis of TGFBR3:ARRB complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58390", "l": "4-amino-3-all-trans-hexaprenylbenzoate + diphosphate => 4-aminobenzoate + all-trans-hexaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004767", "l": "sphingomyelin phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68325", "l": "1D-myo-inositol 2,5-bisphosphate + H2O => 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.514861039037328", "identifiers": [{"i": "GO:0004618", "l": "phosphoglycerate kinase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339535", "l": "CPTP transports C1P from plasma membrane to Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68491", "l": "(2R)-2-hydroperoxytetradecanoate + H(+) <=> CO2 + H2O + tridecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374337", "l": "Apelin receptor binds to apelin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60396", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O = Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102907", "l": "sesquisabinene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = diphosphoric acid + sesquisabinene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32378", "l": "limonene-1,2-diol + NAD(+) <=> 1-hydroxylimonen-2-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51187", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + H2O <=> H(+) + octadecanoate + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19827", "l": "(+)-aristolochene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41777", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) => CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28119", "l": "di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose => D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35744", "l": "H(+) + NADPH + O2 + versicolorin B => 2 H2O + NADP(+) + versicolorin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5444523", "l": "Formation of MSH1:PMS2 Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050371", "l": "tyrosine phenol-lyase activity", "d": ["Catalysis of the reaction: L-tyrosine + H2O = NH4 + phenol + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57626", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58109", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] => acetate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692146", "l": "Expression of DHH in testis differentiation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42564", "l": "uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA", "d": [], "t": []}, {"i": "EC:5.4.99.45", "l": "\"tRNA pseudouridine(38/39) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43146", "l": "H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine => adenosine(22) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191830", "l": "snRNP nuclear import and release (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41118", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109702", "l": "PDPK1 phosphorylates AKT2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74742", "l": "Phosphorylation of SHC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102307", "l": "erythromycin C 3''-o-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin C = S-adenosyl-L-homocysteine + erythromycin A + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31786", "l": "H2O + tuberculosinyl diphosphate <=> diphosphate + tuberculosinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0140841", "l": "RNA polymerase II C-terminal domain O-GlcNAc transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68960", "l": "DNA polymerase epsilon binds at the origin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28532", "l": "phosphate + xanthosine => H2O + XMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53465", "l": "1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41274", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79127", "l": "L-phenylalanine + taurocholate = L-phenylalanocholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23498", "l": "5-hydroxy-pentanoyl-CoA + acetate => 5-hydroxypentanoate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015208", "l": "guanine transmembrane transporter activity", "d": ["Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670114", "l": "Histone H3.3 deposition at telomere (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9834807", "l": "ILF3 binds PKR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72434", "l": "(E)-caffeate + ATP + H(+) <=> (E)-caffeoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62163", "l": "H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate <=> N-(9Z-octadecenoyl) ethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391211", "l": "Trace amine-associated receptors can bind trace amines (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74064", "l": "2-aminoisobutanoate(out) + L-alanine(in) => 2-aminoisobutanoate(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11645", "l": "a (2R,3R)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.113", "l": "\"deoxyguanosine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19912", "l": "(S)-lactate + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56952", "l": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60519", "l": "L-tryptophan <=> D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19441", "l": "benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52547", "l": "D-erythronate + NAD(+) <=> 2-dehydro-D-erythronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46947", "l": "(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) <=> H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13563", "l": "(S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+) => H2O + meso-2,6-diaminoheptanedioate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72324", "l": "3 Na(+)(out) + thiosulfate(out) => 3 Na(+)(in) + thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199299", "l": "AKT phosphorylates FOXO transcription factors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853429", "l": "PHLDA1 binds AURKA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62657", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate => 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619355", "l": "CaMKK autophosphorylates in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399939", "l": "Autophosphorylation of PAK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38723", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64519", "l": "2-hydroxyethane-1-sulfonate + NAD(+) <=> H(+) + NADH + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.14", "l": "\"rhodopsin kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43305", "l": "3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer => 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.1", "l": "\"pepsin A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296421", "l": "NLRP3 oligomerizes via NACHT domains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17214", "l": "UDP-N-acetyl-alpha-D-glucosamine => UDP-N-acetyl-alpha-D-mannosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247837", "l": "WNT ligands traffic to the Golgi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26283", "l": "acetaldehyde + Co-precorrin-5B + H(+) => Co-precorrin-5A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63869", "l": "(9Z)-octadecenoate + O2 => (2R,9Z)-2-hydroperoxyoctadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45355", "l": "9,10-epoxyoctadecanoate + H2O <=> 9,10-dihydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33607", "l": "(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015170", "l": "propanediol transmembrane transporter activity", "d": ["Enables the transfer of propanediol from one side of a membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749320", "l": "CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654159", "l": "Activated FGFR2 binds PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047593", "l": "6-acetylglucose deacetylase activity", "d": ["Catalysis of the reaction: 6-acetyl-D-glucose + H2O = D-glucose + acetate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40798", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56732", "l": "4,4-dihydroxy-all-trans-beta-carotene = echinenone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49095", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21393", "l": "2-phenylacetaldehyde + H2O + NAD(+) => 2-phenylacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29409", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+) => 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008703", "l": "5-amino-6-(5-phosphoribosylamino)uracil reductase activity", "d": ["Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + H+ + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416358", "l": "G alpha (q) inhibits PI3K alpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57233", "l": "GDP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4341048", "l": "SUMOylation of RXRA with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169921", "l": "Glycosylation and Folding of HA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29593", "l": "H(+) + NADPH + sulfoacetaldehyde => 2-hydroxyethane-1-sulfonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53265", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38252", "l": "hexadecan-1-ol + octadecanoyl-CoA => CoA + hexadecanyl octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22387", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O <=> 1D-myo-inositol hexakisphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78096", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21864", "l": "an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004787", "l": "thiamine diphosphate phosphatase activity", "d": ["Catalysis of the reaction: thiamine diphosphate + H2O = thiamine monophosphate + phosphate."], "t": []}, {"i": "RHEA:27998", "l": "H2O + thiamine diphosphate = H(+) + phosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15464", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379844", "l": "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48958", "l": "[thyroglobulin]-3-iodo-L-tyrosine + 2 H2O => [thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007605", "l": "BRCA1 gene expression is inhibited by E2F6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35697", "l": "(2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH => (3S)-versiconol acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77295", "l": "a ganglioside GD3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GT3 + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16083", "l": "(2R)-S-methyl-1-thioglycerate + phosphate => (2R)-S-methyl-3-phospho-1-thioglycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62475", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58474", "l": "CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40429", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32638", "l": "linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621918", "l": "Defective GCK does not phosphorylate Glc to form G6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018804", "l": "RAC3 GEFs activate RAC3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61639", "l": "ATP + CoA + isophthalate <=> AMP + diphosphate + isophthalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21007", "l": "(R)-pantolactone + A <=> 2-dehydropantolactone + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53315", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13113", "l": "2-acetamidofluorene + H2O + NADP(+) = H(+) + N-hydroxy-2-acetamidofluorene + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73707", "l": "ATP(in) + UDP(out) = ATP(out) + UDP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374298", "l": "Opioid receptors bind opioid peptides (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869580", "l": "DEK binds TFAP2A homodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71768", "l": "2 Fe(2+) + H(+) + NADP(+) => 2 Fe(3+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19364", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate <=> (2E,6E)-farnesyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0050263", "l": "ribosylpyrimidine nucleosidase activity", "d": ["Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52425", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75045", "l": "L-cystine(in) + L-leucine(out) => L-cystine(out) + L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46488", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.13", "l": "\"ABC-type autoinducer-2 transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19453", "l": "2-oxoglutarate + L-alanine = L-glutamate + pyruvate", "d": [], "t": []}, {"i": "EC:2.6.1.2", "l": "\"alanine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54919", "l": "9-cis-retinol + NADP(+) <=> 9-cis-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050503", "l": "trehalose 6-phosphate phosphorylase activity", "d": ["Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209973", "l": "Tyrosine is diiodinated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52871", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate <=> 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977136", "l": "Amyloid precursor proteins form ordered fibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800490", "l": "ATM phosphorylates PIDD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17922", "l": "D-arabinitol + NAD(+) => D-xylulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64531", "l": "AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine <=> 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36504", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA => (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980065", "l": "NOTCH1 stimulates HEY transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.-.-", "l": "\"Glycosyltransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10655", "l": "a long-chain fatty aldehyde + H2O + NAD(+) <=> a long-chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034513", "l": "box H/ACA snoRNA binding", "d": ["Binding to a box H/ACA small nucleolar RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48545", "l": "[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine => [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102357", "l": "mithramycin dehydrogenase activity", "d": ["Catalysis of the reaction: mithramycin + NADP = mithramycin DK + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51125", "l": "uridine in snRNA => pseudouridine in snRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13445", "l": "(R)-pantetheine + H2O = (R)-pantothenate + cysteamine", "d": [], "t": []}, {"i": "EC:3.5.1.92", "l": "\"pantetheine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9845033", "l": "CLIP1-LTK promotes MAPK1 and MAPK3 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45018", "l": "L-selenomethionine + tetrahydropteroyltri-L-glutamate => 5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57107", "l": "[(1->4)-alpha-D-galacturonosyl](n) <=> 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679266", "l": "Beclin-1 complex translocates to the ER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16149", "l": "beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide", "d": [], "t": []}, {"i": "EC:2.4.2.12", "l": "\"nicotinamide phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19328", "l": "H(+) + NADH + O2 + quinolin-4-ol <=> H2O + NAD(+) + quinoline-3,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43401", "l": "N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21652", "l": "2-chlorobenzoate + H(+) + NADH + O2 = catechol + chloride + CO2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645598", "l": "RRAGC,D hydrolyzes GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008110", "l": "L-histidine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74391", "l": "methylamine(out) = methylamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018801", "l": "glutaconyl-CoA decarboxylase activity", "d": ["Catalysis of the reaction: trans-glutaconyl-CoA + H+ = but-2-enoyl-CoA + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56592", "l": "a disubstituted aliphatic (S)-hydroxynitrile = a ketone + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52227", "l": "3 AH2 + 3 H(+) + heme b + 3 O2 <=> 3 A + biliverdin IXdelta + CO + Fe(2+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25791", "l": "4-hydroxy-2-oxoheptanedioate <=> pyruvate + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11336", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.99", "l": "\"3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351208", "l": "Spermidine  => N-acetylated spermidine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59106", "l": "a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+) => a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674140", "l": "PAQR3 binds inactive RAFs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37097", "l": "3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA => (10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73745", "l": "2 H(+)(in) + serotonin(out) => 2 H(+)(out) + serotonin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42474", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+) => dibenzo-p-dioxin + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55211", "l": "(4R)-hydroxysphinganine 1-phosphate <=> (2R)-hydroxyhexadecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202222", "l": "Phosphorylation of PKC theta (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48060", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1500781", "l": "Fgd1 reactivates F420 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66686", "l": "L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31184", "l": "acetyl-CoA + decanoyl-CoA => 3-oxododecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41716", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090612", "l": "cAMP deaminase activity", "d": ["Catalysis of the reaction: cyclic adenosine monophosphate + H2O = cyclic inosine monophosphate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-354173", "l": "Activation of Rap1 by cytosolic GEFs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75067", "l": "chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in) = chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605624", "l": "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374173", "l": "AGT(34-41) binds to AGTR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647980", "l": "mature RAS proteins translocate to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34347", "l": "(2E)-geraniol + NAD(+) = (2E)-geranial + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.347", "l": "\"geraniol dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23061", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP => a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67529", "l": "(6Z)-octenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36511", "l": "(9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = (11Z)-3-oxoicosenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69194", "l": "ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate => ATP + L-glutamate + L-glutamyl-[tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20195", "l": "(R)-mevaldate + H(+) + NADPH => (R)-mevalonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001877", "l": "lipoarabinomannan immune receptor activity", "d": ["Combining with lipoarabinomannan and transmitting the signal to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015389", "l": "pyrimidine- and adenosine-specific:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenosine)(out) + Na+(out) = (pyrimidine nucleoside or adenosine)(in) + Na+(in)."], "t": []}, {"i": "TCDB:2.A.41.2.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675834", "l": "PI(3,4)P2 is transported from the plasma membrane to the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12270", "l": "1-pyrroline + H2O + L-glutamate => 2-oxoglutarate + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12007", "l": "indoxyl + UDP-alpha-D-glucose <=> H(+) + indican + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017130", "l": "poly(C) RNA binding", "d": ["Binding to a sequence of cytosine residues in an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.221", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798667", "l": "TDH tetramer oxidises L-Thr to 2A-3OB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0010209", "l": "vacuolar sorting signal binding", "d": ["Binding to a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036221", "l": "UTP diphosphatase activity", "d": ["Catalysis of the reaction: UTP + H2O = UMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39838", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33931", "l": "all-trans-zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal", "d": [], "t": []}, {"i": "EC:1.13.11.65", "l": "\"carotenoid isomerooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31696", "l": "(9Z,12Z)-octadecadienoate + O2 => (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449811", "l": "IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40427", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802941", "l": "RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205286", "l": "GRB2:SOS interacts with p-KIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072371", "l": "histone H2AS121 kinase activity", "d": ["Catalysis of the reaction: histone H2A-serine (position 121) + ATP = histone H2A-phosphoserine (position 121) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 121 of histone H2A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15706", "l": "2 a ubiquinone + H2O + phenylacetyl-CoA => 2 a ubiquinol + phenylglyoxylyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31202", "l": "(3S)-hydroxyoctanoyl-CoA <=> (2E)-octenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77531", "l": "hydrogen cyanide + nonanal = (2S)-2-hydroxydecanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75437", "l": "14-demethyleburicol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 32-oxoeburicol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734540", "l": "ACLY tetramer binds ETC-1002-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58638", "l": "(9Z)-octadecenamide + glyoxylate => N-(9Z-octadecenoyl)-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005275", "l": "amine transmembrane transporter activity", "d": ["Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.1", "l": "\"DNA topoisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759158", "l": "SQSTM1 oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31860", "l": "(S)-2,3-epoxysqualene => glutinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12411", "l": "L-lysine + NAD(+) <=> 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165195", "l": "GTP loading by Rheb (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45294", "l": "2-glyceryl-prostaglandin H2 + A + H2O => 2-glyceryl-prostaglandin G2 + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190256", "l": "FGFR1c binds to FGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47486", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => deoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60231", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51617", "l": "ATP + formate + H(+) => CO2 + dATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55721", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] => 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162187", "l": "COQ6 hydroxylates DHB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1268025", "l": "SAM50 complex inserts proteins into mitochondrial outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67266", "l": "(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine => (2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21332", "l": "acetyl-CoA + D-glucosamine = CoA + H(+) + N-acetyl-D-glucosamine", "d": [], "t": []}, {"i": "EC:2.3.1.3", "l": "\"glucosamine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73899", "l": "ATP + cadaverine + L-glutamate = ADP + gamma-L-glutamylcadaverine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31214", "l": "ATP + H2O + L-selenomethionine <=> diphosphate + L-adenosylselenomethionine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51307", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate <=> (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9615249", "l": "ARBs bind AGRT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48328", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = a III(4)-a-Fuc-Lc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9652264", "l": "ERBB2 binds TKIs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352059", "l": "SLC6A15-mediated amino acid uptake (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69585", "l": "GMP + inosine => guanosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50862", "l": "13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399930", "l": "Activation of PAK by Rac1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852324", "l": "GTSE1 binds PLK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57449", "l": "ATP + D-tyrosine + tRNA(Tyr) => AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78733", "l": "3-oxoeicosanoyl-CoA + H(+) + NADH => (3S)-hydroxyeicosanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858321", "l": "DHTKD1 dimer decarboxylates 2-OA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0038054", "l": "G protein-coupled estrogen receptor activity", "d": ["Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46351", "l": "(2E)-octenoyl-CoA + H2O <=> 3-hydroxyoctanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693540", "l": "MRN activates ATM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.136", "l": "\"polysialic-acid O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0008271", "l": "secondary active sulfate transmembrane transporter activity", "d": ["Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50681", "l": "H2O + N-terminal L-glutaminyl-[protein] => N-terminal L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76388", "l": "ATP + L-glutamate + N(6)-hydroxy-L-lysine => 1-L-glutamo-2-N(6-)L-lysinohydrazine + AMP + diphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23611", "l": "H(+) + H2O + N-isopropylammelide <=> cyanurate + isopropylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32923", "l": "H2O + sn-glycero-3-phospho-(1'-sn-glycerol) = glycerol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839110", "l": "HTRA2 degrades NDUFA13 (GRIM-19) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196964", "l": "RFK:Mg2+ phosphorylates RIB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72596", "l": "H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out) => H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141069", "l": "receptor ligand inhibitor activity", "d": ["Binds to and decreases the activity of the ligand of a signaling receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000074", "l": "TCN2 binds RCbl in the circulation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418856", "l": "Activation of Rac1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59857", "l": "Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium => methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874849", "l": "CREBRF binds CREB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357828", "l": "RIPK1 is cleaved by CASP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000120", "l": "CBLIF binds RCbl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36840", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009227", "l": "IL20 binds to IL22RA1:JAK1:IL20RB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432148", "l": "Fgr may phosphorylate p38 MAPK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19911", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate => (S)-lactate + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32219", "l": "all-trans-lycopene = gamma-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19988", "l": "NAD(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADH + S-formylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46576", "l": "H(+) + NADPH + O2 + sitosterol = 2 H2O + NADP(+) + stigmasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64713", "l": "1-propanol + NADP(+) => H(+) + NADPH + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62580", "l": "ATP + D-cystine(out) + H2O = ADP + D-cystine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54657", "l": "linalool => (2E)-geraniol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111930", "l": "Adenylate cyclase produces cAMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48985", "l": "(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + glyoxylate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781897", "l": "USP11 deubiquitinates NFKBIA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.3", "l": "\"NADH oxidase (H2O2-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42039", "l": "chenodeoxycholate + NAD(+) <=> 7-oxolithocholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75881", "l": "methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + N-methyl-L-proline => Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) + L-proline betaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1470009", "l": "Phosphorylation of STATs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.272", "l": "\"D-2-hydroxyacid dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033995", "l": "anhydrosialidase activity", "d": ["Catalysis of the reaction: an N-acetylneuraminate glycoside = 2,7-anhydro-alpha-N-acetylneuraminate + an alpha-sialyl group. This reaction is the elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873918", "l": "Transphosphorylation of JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77856", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-phenylalanine + O2 => 2-dehydro-D-glucose + H2O2 + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784204", "l": "JAKs bind OSMR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693347", "l": "HTR1A binds 5HT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59842", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate => (6S)-5,6,7,8-tetrahydrofolate + syringate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32053", "l": "adenosine 5'-tetraphosphate + AMP + 2 H(+) => H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042897", "l": "polymyxin transmembrane transporter activity", "d": ["Enables the transfer of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327733", "l": "FN1 binds Collagen types I-V, VII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47974", "l": "dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58080", "l": "1-docosanoylglycerol + H2O = docosanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72550", "l": "2-oxoglutarate(in) + taurocholate(out) <=> 2-oxoglutarate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014454", "l": "RHOG translocates to the ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199456", "l": "PTEN dephosphorylates PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75886", "l": "NAD(+) <=> ADP-1-deoxy-1,O(4)-didehydro-D-ribose + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65852", "l": "a 3-oxo-Delta(1)-steroid + H2O = a 1-hydroxy-3-oxo steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23963", "l": "H(+) + 2 H2O2 + hexadecanoate <=> CO2 + 3 H2O + pentadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004103", "l": "choline kinase activity", "d": ["Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25370", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) <=> H(+) + momilactone A + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11507", "l": "6-demethylsterigmatocystin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + sterigmatocystin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709842", "l": "MAVS binds TOMM70 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24020", "l": "2-(N(omega)-L-arginino)succinate = fumarate + L-arginine", "d": [], "t": []}, {"i": "EC:4.3.2.1", "l": "\"argininosuccinate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71324", "l": "chloride(out) + L-asparagine(out) + 2 Na(+)(out) => chloride(in) + L-asparagine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30994", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106433", "l": "O6-methyl-dGTP hydrolase activity", "d": ["Catalysis of the reaction O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+."], "t": []}, {"i": "RHEA:67600", "l": "H2O + O(6)-methyl-dGTP = diphosphate + H(+) + O(6)-methyl-dGMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68384", "l": "(2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein] = (2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57839", "l": "H2O + O2 + thermospermine <=> 3-aminopropanal + H2O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805740", "l": "SETD8 methylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450422", "l": "KSRP recruits RNA degradation activities (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70591", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58031", "l": "5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH <=> a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40817", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15387", "l": "3-cyano-L-alanine + H2O => L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785213", "l": "LIPC dimer binds heparin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955844", "l": "RBKS phosphorylates ribose to R5P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77770", "l": "11-cis-retinol + a fatty acyl-CoA <=> 11-cis-retinyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851919", "l": "Activated MET binds GAB1 and GRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15225", "l": "alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose", "d": [], "t": []}, {"i": "EC:2.7.7.24", "l": "\"glucose-1-phosphate thymidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382058", "l": "Nck binds to the active PDGF receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445069", "l": "L1-EGFR trans-heterodimerization (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75506", "l": "glycocholate(out) + n H(+)(out) <=> glycocholate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690461", "l": "FKBP1A binds tacrolimus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25943", "l": "8-chloroquinoline + A + H2O <=> 8-chloroquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64886", "l": "(6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975594", "l": "PLB1 hydrolyses RPALM to atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71974", "l": "3-hydroxyglutarate(out) + 3 Na(+)(out) <=> 3-hydroxyglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9669854", "l": "KIT binds type II TKIs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981355", "l": "RASA1 binds RAS:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12596", "l": "a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66781", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O => N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76207", "l": "3',5'-cyclic GMP(in) = 3',5'-cyclic GMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102391", "l": "decanoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + decanoate + CoA = AMP + diphosphate + decanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417829", "l": "P2RY12 binds ADP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509831", "l": "ITPA hydrolyses XTP to XMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22762", "l": "CO2 + hnu + oxidized Cypridina luciferin => Cypridina luciferin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20294", "l": "3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) => 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62671", "l": "deoxyherqueinone + H(+) + NADPH + O2 <=> H2O + herqueinone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21804", "l": "ATP + myo-inositol = 1D-myo-inositol 3-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.64", "l": "\"inositol 3-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782943", "l": "UV-DDB ubiquitinates XPC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41555", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + ophiobolin F", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728752", "l": "TAS2R:bitter compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71196", "l": "H(+)(out) + Zn(2+)(out) => H(+)(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29187", "l": "succinate + ubiquinone-8 = fumarate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209760", "l": "Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210426", "l": "Glutamate synaptic vesicle docking and priming (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35175", "l": "novobiocin(in) = novobiocin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444100", "l": "PROT mediates L-proline uptake (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70326", "l": "2,3-dioxo-L-gulonate <=> 2-carboxy-L-lyxonolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55140", "l": "D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72980", "l": "didemethylasterriquinone D + dimethylallyl diphosphate => asterriquinone C1 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77519", "l": "furfural + hydrogen cyanide = (2R)-2-(furan-2-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322431", "l": "XIAP binds TLE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046180", "l": "KSPG is secreted from the cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102595", "l": "cyanidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose = cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(6-O-(p-hydroxybenzoyl)-glucosyl)-oxybenzoyl)-glucoside) + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64280", "l": "(S)-1-phenylethylamine + pyruvate = acetophenone + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34798", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O <=> alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0120015", "l": "sterol transfer activity", "d": ["Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676599", "l": "sBAFF trimer binds BAFFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.2", "l": "\"DNA topoisomerase (ATP-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427409", "l": "Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975880", "l": "MyD88 oligomerization within the complex of activated TLR:MyD88 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65006", "l": "AMP + decanoyl-[ACP] + diphosphate => ATP + decanoate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850797", "l": "SPINK6 binds KLK13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0050543", "l": "icosatetraenoic acid binding", "d": ["Binding to icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45081", "l": "3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine => ADP + dapdiamide E + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66259", "l": "ATP + H(+) + IC-asc-C7 <=> diphosphate + IC-asc-C7-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62076", "l": "D-galactose 6-phosphate + NAD(+) = 6-phospho-D-galactono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77312", "l": "glyoxylate + N(omega),N(omega)-dimethyl-L-arginine => 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51626", "l": "CO2 + dGTP + H2O => formate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11895", "l": "6-O-methylnorlaudanosoline + S-adenosyl-L-methionine <=> H(+) + nororientaline + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31132", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25064", "l": "3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH => 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11920", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.96", "l": "\"4a-hydroxytetrahydrobiopterin dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.165", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33093", "l": "2-demethylmenaquinol-8 + CO2 + diphosphate => 1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12542", "l": "AMP + diphosphate + L-alanyl-tRNA(Ala) => ATP + L-alanine + tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10043", "l": "adenosine 3',5'-bisphosphate + H2O <=> AMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5607746", "l": "PKC-delta is activated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41808", "l": "(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16861", "l": "(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate", "d": [], "t": []}, {"i": "EC:2.6.1.62", "l": "\"adenosylmethionine--8-amino-7-oxononanoate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56980", "l": "4-hydroxybenzyl alcohol + 2 oxidized [azurin] = 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33944", "l": "H(+) + 2 L-arginine + 3 NADH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035976", "l": "Defective HEXA does not cleave the terminall GalNAc from small HA fragments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70994", "l": "SDH complex dehydrogenates succinate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30953", "l": "alpha-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12371", "l": "2-dehydro-D-gluconate + A <=> 2,5-didehydro-D-gluconate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40368", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23817", "l": "2-oxoglutarate + putrescine => 4-aminobutanal + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35925", "l": "3''-deamino-3''-hydroxykanamycin B + H(+) + UDP => neamine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63727", "l": "candesartan + UDP-alpha-D-glucuronate <=> candesartan O-beta-D-glucuronoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44868", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol = 1,2-diacyl-sn-glycero-3-phosphoethanol + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209330", "l": "Phosphorylated BSK kinase and the AP-1 transcription factor, JRA:KAY, bind to CKA scaffolding protein in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004817", "l": "cysteine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977363", "l": "Factor H binds to C3bBb (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065355", "l": "Secreted ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939203", "l": "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36457", "l": "ADP + H(+) + L-alanylglycine(in) + phosphate => ATP + H2O + L-alanylglycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22130", "l": "(1S,4S)-camphor + H(+) + NADH => (1S,2R,4S)-borneol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034186", "l": "apolipoprotein A-I binding", "d": ["Binding to apolipoprotein A-I."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005138", "l": "interleukin-6 receptor binding", "d": ["Binding to an interleukin-6 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102701", "l": "tricyclene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate(3-) = tricyclene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047256", "l": "lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity", "d": ["Catalysis of the reaction: a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57820", "l": "[phosphate](n) + ADP = [phosphate](n+1) + AMP", "d": [], "t": []}, {"i": "EC:2.7.4.33", "l": "\"AMP-polyphosphate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868134", "l": "CAST binds Ca2+ bound calpain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69135", "l": "cadaverine + H2O + O2 <=> 5-aminopentanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56019", "l": "H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692867", "l": "HRH3 binds pitosilant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936380", "l": "Interaction of PIN1 with p-IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42182", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14839", "l": "H(+) + H2O2 + oxalate => glyoxylate + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787737", "l": "CSF3R binds CSF3 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75861", "l": "all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.80", "l": "\"methylcytosine dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42669", "l": "L-rhamnofuranose + NADP(+) => H(+) + L-rhamnono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46157", "l": "15,9'-di-cis-phytofluene + a plastoquinone => 9,9',15-tri-cis-zeta-carotene + a plastoquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53236", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] = (24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.111", "l": "\"mycocerosate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68684", "l": "3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate) = adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72885", "l": "2 AMP + 2 diphosphate + H(+) + polyporic acid => 2 3-phenylpyruvate + 2 ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79019", "l": "2-oxoglutarate + N(1)-methyladenosine(58) in tRNA + O2 = adenosine(58) in tRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60919", "l": "a cytidine in mRNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018826", "l": "RHOT2 hydrolyzes GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199131", "l": "PVR binds CD226 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869694", "l": "oxPL binds CD14 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79075", "l": "(4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside + UDP-alpha-D-glucuronate = (4Z,15Z)-bilirubin IXalpha C8,C12-beta-D-bisglucuronoside + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44693", "l": "a fatty acyl-CoA + hexadecasphinganine => CoA + H(+) + N-acylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693148", "l": "BCKDK phosphorylates BCKDH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14895", "l": "(2R,4S)-2,4-diaminopentanoate => D-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58957", "l": "a ribonucleotide in RNA + S-adenosyl-L-methionine => a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49056", "l": "asperlicin C + H(+) + NADPH + O2 = asperlicin E + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31145", "l": "3-oxohexanoyl-CoA + H(+) + NADH => (3S)-hydroxyhexanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0046508", "l": "hydrolase activity, acting on carbon-sulfur bonds", "d": ["Catalysis of the hydrolysis of any carbon-sulfur bond, C-S."], "t": []}, {"i": "EC:3.13.-.-", "l": "\"Acting on carbon-sulfur bonds\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21889", "l": "(1S,2S)-OPC-8 + NADP(+) => (9S,13S,15Z)-12-oxophyto-10-15-dienoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864595", "l": "TFAP2B homodimer binds YEATS4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10124", "l": "H(+) + NADPH + O2 + phenylacetone = benzyl acetate + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.92", "l": "\"phenylacetone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14067", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O => scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18477", "l": "2,3-dihydroxybenzoate + O2 = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.14", "l": "\"2,3-dihydroxybenzoate 3,4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57381", "l": "(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69245", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate => 5-methylsulfinylpentyl nitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39516", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH => (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203712", "l": "eNOS associates with Caveolin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73493", "l": "Co(2+)(in) + 2 hydrogencarbonate(in) => Co(2+)(out) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75117", "l": "all-trans-13,14-dihydroretinal + H(+) + NADH => all-trans-13,14-dihydroretinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70678", "l": "H2O + Met-enkephalin-Arg-Phe <=> L-arginyl-L-phenylalanine + Met-enkephalin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16425", "l": "formaldehyde + H2O + NAD(+) = formate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.46", "l": "\"formaldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022893", "l": "low-affinity tryptophan transmembrane transporter activity", "d": ["Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61468", "l": "a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72541", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH => 3,4-dihydroxybenzaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64814", "l": "CoA + H(+) + S-(2-acetamidoethyl)-homocysteine => acetyl-CoA + S-(2-aminoethyl)-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41434", "l": "5-hydroxy-3-methyl-L-tyrosine + H2O => 3-methyl-L-tyrosine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717382", "l": "SCN9A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62240", "l": "a thymidine(6-4)cytidine in DNA = a thymine-cytidine dinucleotide in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.8", "l": "\"4-hydroxy-tetrahydrodipicolinate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73797", "l": "FAICAR => IMP + H2O (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088220", "l": "Endorepellin binds alpha2beta1 integrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195926", "l": "Association with M1 at cell membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75746", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH <=> 10-hydroxy-(11E)-octadecenoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19547", "l": "glycerol + H(+) + phosphocholine => H2O + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57967", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44843", "l": "(R)-carnitine + octadecanoyl-CoA <=> CoA + O-octadecanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782685", "l": "EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18275", "l": "4-aminobutanal + H2O2 + NH4(+) => H2O + O2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42581", "l": "ATP + L-serine + tRNA(Sec) => AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098973", "l": "structural constituent of postsynaptic actin cytoskeleton", "d": ["The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62691", "l": "4 norrubrofusarin + O2 <=> 2 H2O + 2 ustilaginoidin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11095", "l": "NAD(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69370", "l": "17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH => 11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9865893", "l": "MT-CYB is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018651", "l": "toluene-4-sulfonate monooxygenase activity", "d": ["Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909732", "l": "Phosphorylation of STAT2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953339", "l": "DNPH1 hydrolyses dGMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46496", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) = N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351894", "l": "Caspase mediated cleavage of BAP31 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16345", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.167", "l": "\"dolabella-3,7-dien-18-ol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21264", "l": "A + glycolate = AH2 + glyoxylate", "d": [], "t": []}, {"i": "EC:1.1.99.14", "l": "\"glycolate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59442", "l": "(S)-isodihydrodehydrodiconiferyl alcohol + NADP(+) => (-)-dehydrodiconiferyl alcohol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183122", "l": "Factor D cleaves C3b-bound Factor B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13700", "l": "ATP + D-ribose <=> ADP + D-ribose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21989", "l": "malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside => 4'''-demalonylsalvianin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658574", "l": "PARK2 binds SNCAIP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74790", "l": "L-histidyl-L-proline diketopiperazine(in) <=> L-histidyl-L-proline diketopiperazine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052790", "l": "chitooligosaccharide deacetylase activity", "d": ["Catalysis of the reaction: chitooligosaccharide with N-acetylglucosamine at nonreducing terminal + H2O = chitooligosaccharide with glucosamine at nonreducing terminal + acetate. This reaction is the deacetylation of a chitooligosaccharide at the nonreducing N-acetylglucosamine residue; chitooligosaccharide are composed of (1->4)-linked D-glucosamine (GlcN) and N-acetyl-D-glucosamine (GlcNAc) in varying proportions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10171", "l": "15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] <=> biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684071", "l": "RNF4 ubiquitinates MDC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47163", "l": "4beta-methylzymosterol-4alpha-carboxylate + NAD(+) <=> 3-dehydro-4-methylzymosterol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793444", "l": "ITCH polyubiquitinates MLKL at K50 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68603", "l": "ORC5 binds ORC2:ORC3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9823065", "l": "GPIb:IX:V binds to VWF multimer:collagen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56278", "l": "3'-L-prolyl-AMP + diphosphate => ATP + L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50648", "l": "2-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63388", "l": "2 A + Fe(II)-heme o + H2O = 2 AH2 + Fe(II)-heme a", "d": [], "t": []}, {"i": "EC:1.17.99.9", "l": "\"heme a synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16021", "l": "oxaloacetate = enol-oxaloacetate", "d": [], "t": []}, {"i": "EC:5.3.2.2", "l": "\"oxaloacetate tautomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072549", "l": "monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: monocoumaroyl dicaffeoyl spermidine + NADPH + O2 = tricaffeoyl spermidine + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37221", "l": "3-methyl-2-oxobutanoate + AH2 + NH4(+) => A + D-valine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867041", "l": "EGFR phosphorylates EPS15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56829", "l": "2,3,6-trichlorohydroquinone + chloride + glutathione disulfide => 2,3,5,6-tetrachlorohydroquinone + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24911", "l": "L,L-cystathionine => 2-aminobut-2-enoate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75849", "l": "SLC25A1 exchanges CIT and MAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.16", "l": "\"cathepsin H\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247837", "l": "WNT ligands traffic to the Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55360", "l": "11-cis-retinol = 9-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0044390", "l": "ubiquitin-like protein conjugating enzyme binding", "d": ["Binding to a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60726", "l": "dodecanoate + 2 H(+) + NADPH => dodecanal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78726", "l": "3'-dehydromaltose + H2O <=> 3-dehydro-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654422", "l": "Activated FGFR4 binds FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9866253", "l": "apo-UQCRFS1 binds LYRM7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56777", "l": "(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45156", "l": "3-oxopropanoyl-CoA + H2O = 3-oxopropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015438", "l": "ABC-type teichoic acid transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36782", "l": "2-oxoglutarate + GDP-alpha-D-perosamine <=> GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49579", "l": "AH2 + GTP + S-adenosyl-L-methionine <=> (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12864", "l": "guanosine + H(+) + H2O <=> NH4(+) + xanthosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190662", "l": "Connexin oligomerization in Trans-Golgi Network (TGN) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70979", "l": "MDH2 dimer dehydrogenates MAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57433", "l": "3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] => 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660965", "l": "CCL17 and CCL22 genes are transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71078", "l": "L-arginine(in) + L-cystine(out) <=> L-arginine(out) + L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57912", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) = H(+) + L-glutaminyl-tRNA(Gln) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72357", "l": "dehydroepiandrosterone 3-sulfate(in) + glutarate(out) => dehydroepiandrosterone 3-sulfate(out) + glutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12343", "l": "L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] <=> H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45689", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in) => N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17923", "l": "D-xylulose + H(+) + NADH => D-arabinitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31199", "l": "(3S)-hydroxyoctanoyl-CoA = (2E)-octenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098505", "l": "G-rich strand telomeric DNA binding", "d": ["Binding to G-rich, single-stranded, telomere-associated DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19015", "l": "dTDP + H(+) + phosphate => dTTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63136", "l": "adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione = cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12128", "l": "2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.4.7.1", "l": "\"glutamate synthase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74953", "l": "(3R)-3-isocyanylbutanoate + 2 CO2 + 2 H2O + succinate => (3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015225", "l": "biotin transmembrane transporter activity", "d": ["Enables the transfer of biotin from one side of a membrane to the other. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.62", "l": "\"magnolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048502", "l": "ABC-type thiamine transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamine(out) = ADP + H+ + phosphate + thiamine(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678327", "l": "MIOX oxidises Ins to GlcA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47792", "l": "cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851109", "l": "NPM1-ALK- and STAT3-dependent TWIST gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20426", "l": "2-oxoglutarate + ATP + hydrogencarbonate => (S)-oxalosuccinate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48057", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O => beta-D-glucosylceramide + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56927", "l": "ATP + L-threonyl-[Goodpasture antigen-binding protein] <=> ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38615", "l": "cyclic ADP-beta-D-ribose + H2O = ADP-D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70705", "l": "D-cycloserine(out) + H(+)(out) => D-cycloserine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64915", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913374", "l": "Phosphorylated SHC1 recruits SHIP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72058", "l": "glycodeoxycholate(out) + 2 Na(+)(out) <=> glycodeoxycholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014449", "l": "RHOG binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990756", "l": "ubiquitin-like ligase-substrate adaptor activity", "d": ["The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69796", "l": "D-aspartyl-tRNA(Asp) + H2O => D-aspartate + H(+) + tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955844", "l": "RBKS phosphorylates ribose to R5P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59898", "l": "ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate => ATP + L-glutamate + L-propargylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78099", "l": "a 1-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062067", "l": "chloroplast photosystem I binding", "d": ["Binding to a chloroplast photosystem I."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41006", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173636", "l": "Formation of classic pathway C5 convertase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5622134", "l": "CRABP1 binds atRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13315", "l": "formaldehyde + glycine + H2O2 => H2O + O2 + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50595", "l": "13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) <=> 15-oxoprostaglandin F1alpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032041", "l": "NAD-dependent histone H3K14 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20828", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.65", "l": "\"phosphatidylserine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76063", "l": "3'-phosphoadenylyl sulfate(in) + adenosine 3',5'-bisphosphate(out) = 3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9854920", "l": "MITF-M dimer binds SIRT1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676599", "l": "sBAFF trimer binds BAFFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856223", "l": "B4GALNT1 dimer transfers GalNAc to gangliosides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65152", "l": "(2S)-naringenin + UDP-alpha-D-glucose = (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.-", "l": "\"Oxygenases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098627", "l": "protein arginine phosphatase activity", "d": ["Catalysis of the reaction: phospho-L-arginyl-[protein] +H2O = L-arginyl-[protein] + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40458", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA <=> (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56533", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856951", "l": "PP2A demethylation by PPME1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53994", "l": "(14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062187", "l": "anandamide 8,9 epoxidase activity", "d": ["Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]."], "t": []}, {"i": "RHEA:53140", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62841", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30467", "l": "(2Z,6Z)-farnesyl diphosphate = (+)-endo-beta-bergamotene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.53", "l": "\"(+)-endo-beta-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62565", "l": "(4S)-limonene + A + H2O => (4S)-perillyl alcohol + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40615", "l": "H2O + tridecanoylglycerol = 2,3-didecanoyl-sn-glycerol + decanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33092", "l": "1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000297", "l": "spermine transmembrane transporter activity", "d": ["Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419841", "l": "Light stimulates opsin receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77914", "l": "a 3'-end 2'-deoxyribonucleotidyl-deoxyribonucleotide-DNA + H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + a 3'-end 2'-deoxyribonucleotide-DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12762", "l": "precorrin-3B + S-adenosyl-L-methionine => 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687465", "l": "MRN complex binds RBBP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17719", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5-trisphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63409", "l": "6-chloropyridine-2,3,5-triol + FADH2 + O2 => 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47222", "l": "3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18853", "l": "NAD(+) + tartrate = 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38470", "l": "a 2-acylglycerol + an acyl-CoA <=> a 2,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49004", "l": "aurachin C + H(+) + NADPH + O2 = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35761", "l": "aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase] => 8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697855", "l": "Superoxide and nitric oxide react to form peroxynitrite in mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65769", "l": "a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961991", "l": "E2F1 binds the TK1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51800", "l": "deoxyadlupulone + dimethylallyl diphosphate = adlupulone + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49110", "l": "3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine => Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112395", "l": "Abortive termination of elongation after arrest (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58112", "l": "1''-O-acetyl-ADP-alpha-D-ribose + H2O = acetate + ADP-D-ribose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49542", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate => (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49242", "l": "L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in) => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688834", "l": "ATXN3 binds VCP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28720", "l": "adenine(in) + H(+)(in) => adenine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213017", "l": "Auto-ubiquitination of TRAF3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086083", "l": "SUMOylation of ING2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25058", "l": "(E)-cinnamate + H(+) + NADH + O2 = (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071077", "l": "adenosine 3',5'-bisphosphate transmembrane transporter activity", "d": ["Enables the transfer of adenosine 3',5'-bisphosphate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59877", "l": "(indol-3-yl)butanoate + ATP + L-cysteine => (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37353", "l": "cytidine + phosphate => cytidine 2'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0106254", "l": "lipid sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of a lipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58129", "l": "A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine => AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54022", "l": "CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein] => L-lysyl-[protein] + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611277", "l": "P2RY12 binds P2RY12 antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71810", "l": "a 2'-deoxyguanosine in DNA + NAD(+) <=> an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482860", "l": "DLCL transports from the IM to the ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61928", "l": "(R)-miconazole(in) + ATP + H2O = (R)-miconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46138", "l": "2 H2O + NADP(+) + pyrrolnitrin => aminopyrrolnitrin + H(+) + NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0140272", "l": "exogenous protein binding", "d": ["Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686578", "l": "Activated ATM phosphorylates ABL1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030748", "l": "amine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73880", "l": "histamine(out) => histamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13496", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690702", "l": "LYN phosphorylates CD22 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-606349", "l": "Mis18 complex binds the centromere (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16835", "l": "glutathione disulfide + 2 H2O => 2 glutathione + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332235", "l": "CBL binds TGFBR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018466", "l": "limonene-1,2-diol dehydrogenase activity", "d": ["Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44465", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => a 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64497", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] => 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682388", "l": "Autophagosome maturation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9824897", "l": "p-S-TBK1 phosphorylates OPTN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30807", "l": "L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36273", "l": "formaldehyde + H2O + NADP(+) + theobromine => caffeine + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.35", "l": "\"2-dehydrotetronate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204863", "l": "Interaction of Tie2 with Ang2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369052", "l": "ABCAs mediate lipid influx (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31828", "l": "(2E,6E)-farnesyl diphosphate => (+)-gamma-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.350", "l": "\"menaquinone C(8)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446364", "l": "Migfilin interacts with VASP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187828", "l": "Translocation of p21 to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59286", "l": "D-glucose + N-octadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77609", "l": "Binding of APOBEC-1 to form editosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061990", "l": "beta-ketodecanoyl-[acyl-carrier-protein] synthase activity", "d": ["Catalysis of the reaction: octanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839367", "l": "TGFBR3_mem cleavage by MMPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004994", "l": "somatostatin receptor activity", "d": ["Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32796", "l": "ATP + H2O + L-cysteine(out) => ADP + H(+) + L-cysteine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45835", "l": "(3R)-3-hydroxydecanoyl-CoA + NAD(+) <=> 3-oxodecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76211", "l": "GMP(in) = GMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14939", "l": "all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008479", "l": "tRNA-guanosine(34) queuine transglycosylase activity", "d": ["Catalysis of the reaction: guanosine34 in tRNA + queuine = guanine + queuosine34 in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201457", "l": "BMP2 binds to the receptor complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69057", "l": "H(+) + N(omega)-methyl-L-arginine + NADH + O2 => H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18708", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75244", "l": "FASL binds FAS Receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682695", "l": "nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54181", "l": "a long-chain fatty aldehyde + holo-[ACP] + NAD(+) => a long-chain fatty acyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47224", "l": "dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700114", "l": "NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30681", "l": "beta-D-glucose + D-glucose => D-cellobiose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50923", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 <=> chromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449058", "l": "Interleukin-1 family are secreted (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27396", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 <=> dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093332", "l": "p-EPHB phosphorylates SDC2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48728", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57085", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19736", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) <=> bacteriochlorophyllide a + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65651", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine <=> a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944233", "l": "Association of procollagen type XIX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836500", "l": "IKK complex is activated by PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62915", "l": "H(+) + NADH + O2 + toralactone <=> 1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61031", "l": "itaconate + L-cysteinyl-[protein] <=> S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49805", "l": "2-methylpropan-1-amine + FMNH2 + O2 => FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10030", "l": "2-oxoglutarate + H2O2 + NH4(+) => D-glutamate + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018744", "l": "limonene-1,2-epoxide hydrolase activity", "d": ["Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928591", "l": "EPH:EFN tetramers oligomerise (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682863", "l": "RNF168 binds DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390425", "l": "FAR1 reduces PalmCoA to HXOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12170", "l": "acrolein + H(+) + NADPH => allyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68505", "l": "(2Z,6Z)-farnesyl diphosphate => (Z)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047803", "l": "cysteine lyase activity", "d": ["Catalysis of the reaction: L-cysteine + sulfite = L-cysteate + sulfide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41376", "l": "1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49839", "l": "(5E)-tetradecenoyl-CoA + (R)-carnitine <=> (5E)-tetradecenoyl-(R)-carnitine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167427", "l": "Opioid dissociates from MOR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23658", "l": "3-carboxy-cis,cis-muconate + H(+) => 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186780", "l": "Degradation of Ub-SMAD7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58763", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15550", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849428", "l": "PTPN1 binds PTK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41691", "l": "1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090614", "l": "5'-methylthioadenosine deaminase activity", "d": ["Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13498", "l": "5-dehydro-2-deoxy-D-gluconate + ATP => 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73866", "l": "dopamine(out) <=> dopamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008412", "l": "CDK4 phosphorylates RUNX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48856", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47003", "l": "H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047836", "l": "D-tryptophan N-malonyltransferase activity", "d": ["Catalysis of the reaction: D-tryptophan + malonyl-CoA = N(2)-malonyl-D-tryptophan + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070457", "l": "D-galactose-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140663", "l": "ATP-dependent FeS chaperone activity", "d": ["Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186785", "l": "PDGF-AA clevage by Furin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69127", "l": "Formation of the Flap Intermediate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909721", "l": "Translocation of ISGF3 complex to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61141", "l": "(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + myricetin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20126", "l": "H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212356", "l": "Formation of CSL-NICD coactivator complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28709", "l": "Cd(2+)(out) => Cd(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483219", "l": "PC is exchanged with PI by PITPNB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670619", "l": "Defective ATRX does not bind DAXX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31022", "l": "4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 <=> 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.24", "l": "\"lipopolysaccharide heptosyltransferase II\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60369", "l": "urate(out) => urate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709842", "l": "MAVS binds TOMM70 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75330", "l": "chloride(out) + D-tryptophan(out) + 2 Na(+)(out) <=> chloride(in) + D-tryptophan(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10461", "l": "prostaglandin A1 => prostaglandin C1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20922", "l": "3,5-dichlorocatechol + H2O + NADP(+) => 2,4-dichlorophenol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.89", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.11", "l": "\"galactosylceramide sulfotransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59360", "l": "carnosine + H2O = beta-alanine + L-histidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49396", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.172", "l": "\"protein-ribulosamine 3-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76060", "l": "heliamine + S-adenosyl-L-methionine => H(+) + N-methylheliamine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72694", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51517", "l": "(R)-reticuline + S-adenosyl-L-methionine => (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78669", "l": "3-oxotetradecanoyl-CoA + H(+) + NADH => (3R)-hydroxytetradecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20742", "l": "(2R,3S)-tartrate => H2O + trans-2,3-epoxysuccinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76066", "l": "3'-phosphoadenylyl sulfate(in) + adenosine 3',5'-bisphosphate(out) <=> 3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39366", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA <=> (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034580", "l": "4-methyloctanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 4-methyloctanoyl-CoA = 4-methyloct-2-enoyl-CoA + 2 H+ + 2 e-."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195251", "l": "Assembly of the destruction complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878056", "l": "RUNX1:CBFB binds EP300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209322", "l": "In the absence of ARM, GRO binds to PAN and inhibits transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420128", "l": "SRC-1 phosphorylates SHB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671772", "l": "p-T38-PPP1R14A binds MLCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9860273", "l": "Dimerization of p-S446-IRF5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187303", "l": "SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73811", "l": "L-proline(in) = L-proline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12003", "l": "formate + NADP(+) <=> CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70122", "l": "6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50418", "l": "H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20380", "l": "androsterone + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682026", "l": "MRN bound to shortened telomeres activates ATM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67092", "l": "ATP + docosanoate(in) + H2O = ADP + docosanoate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34038", "l": "O2 + paromamine <=> 6'-oxoparomamine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14881", "l": "3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) = asparagusate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.8.1.11", "l": "\"asparagusate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432054", "l": "Aquaporin-1 passively transports water out of cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012349", "l": "ME3 tetramer decarboxylates MAL to PYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429101", "l": "HMIT co-transports myo-inositol with a proton (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10831", "l": "anthranilate + ATP + CoA <=> AMP + anthraniloyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295599", "l": "SPRY2 translocates to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170149", "l": "Translocation of active Cdc25C to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20526", "l": "ATP + ethylamine + L-glutamate => ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65713", "l": "alpha-D-glucose 1-phosphate + GDP-beta-L-galactose => beta-L-galactose 1-phosphate + GDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0042288", "l": "MHC class I protein binding", "d": ["Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63137", "l": "adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione => cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65524", "l": "9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71062", "l": "L-arginine(in) + L-leucine(out) <=> L-arginine(out) + L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801195", "l": "STEAP3 binds BNIP3L (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854209", "l": "TBC1D10A binds JFC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174119", "l": "Free APC/C phosphorylated by Plk1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10631", "l": "phosphate + tRNA(n+1) <=> a ribonucleoside 5'-diphosphate + tRNA(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27359", "l": "iodomethane + S-adenosyl-L-homocysteine => iodide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63851", "l": "2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 <=> 2 3',4'-dihydroxyaurone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693478", "l": "HTR1A binds HTR1A agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098680", "l": "template-free RNA nucleotidyltransferase", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the addition of a terminal nucleotide to an RNA molecule in the absence of a nucleic acid template."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2029468", "l": "Conversion of PA into DAG by PAP-1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73155", "l": "adenosine 3',5'-bisphosphate(out) + FMN(in) = adenosine 3',5'-bisphosphate(in) + FMN(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42457", "l": "4alpha-methylzymosterol => zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507875", "l": "Aquaporins passively transport urea into cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11305", "l": "(S)-ureidoglycolate => glyoxylate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11585", "l": "L-ornithine => D-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858913", "l": "MITF-M-dependent ATP6V0C gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879562", "l": "SLCO2B1 has a narrow substrate specificity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5225649", "l": "RBBP7 binds histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49717", "l": "3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 => 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031216", "l": "neopullulanase activity", "d": ["Catalysis of the hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9824732", "l": "G or G analog binds C-ter TLR7 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028598", "l": "Phosphorylation of YAP by LATS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009309", "l": "RUNX2 binds STUB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10358", "l": "5beta-androstane-3,17-dione + H(+) + NADH => 3alpha-hydroxy-5beta-androstan-17-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43494", "l": "chlorophyll b + H(+) + NADPH => 7(1)-hydroxychlorophyll a + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045548", "l": "phenylalanine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-phenylalanine = NH4 + trans-cinnamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57927", "l": "H2O + mutildienyl diphosphate <=> diphosphate + premutilin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.2.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39430", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH <=> (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75137", "l": "H(+) + NADPH + neopinone => NADP(+) + neopine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0005024", "l": "transforming growth factor beta receptor activity", "d": ["Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140761", "l": "sequestered tissue factor -> tissue factor (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22785", "l": "(2R)-O-phospho-3-sulfolactate => H(+) + phosphoenolpyruvate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15129", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.99", "l": "\"(S)-limonene 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035496", "l": "lipopolysaccharide-1,5-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832230", "l": "Expression of POU3F3 during nephron development (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011595", "l": "GSTZ1 dimer dehalogenates DCA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71102", "l": "androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) <=> androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58559", "l": "15alpha-stemmadenine intermediate II + H2O <=> (16S)-deshydroxymethyl-stemmadenine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40757", "l": "1-(9Z,12Z)-octadecadienoylglycerone 3-phosphate + hexadecanoate => (9Z,12Z)-octadecadienoate + 1-hexadecanoylglycerone 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165195", "l": "GTP loading by Rheb (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59950", "l": "CoA + H(+) + prostaglandin F2alpha => H2O + prostaglandin F2alpha-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202472", "l": "Translocation of TRAF6 to CBM complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76013", "l": "(3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate tetramer + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940959", "l": "Neurolysin degrades neurotensin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191636", "l": "Phosphorylation of Cx43 by c-src (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74265", "l": "n H(+)(in) + spermine(out) => n H(+)(out) + spermine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612534", "l": "Expression of ID2 and ID4 is repressed by EGR2:NAB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51903", "l": "H2O + N(1)-acetylspermidine <=> acetate + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74650", "l": "GTP + N-acetyl-D-glucosamine <=> GDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75295", "l": "chloride(in) + sulfate(out) = chloride(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.265", "l": "\"phosphatidylinositol dimannoside acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9824986", "l": "XPO1-dependent export of p-S69,S73 MITF-M (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18931", "l": "5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O => AH2 + O2 + thiophene-2-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32522", "l": "(2E)-geranyl diphosphate + S-adenosyl-L-methionine <=> (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74059", "l": "PDE6 hydrolyses cGMP to GMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004038", "l": "allantoinase activity", "d": ["Catalysis of the reaction: allantoin + H2O = allantoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26273", "l": "Co-precorrin-3 + S-adenosyl-L-methionine = Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78907", "l": "a short-chain fatty acyl-CoA + acetyl-CoA = a short-chain 3-oxoacyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8856951", "l": "PP2A demethylation by PPME1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15401", "l": "a dolichyl phosphate + UDP-alpha-D-glucose = a dolichyl beta-D-glucosyl phosphate + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.117", "l": "\"dolichyl-phosphate beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17210", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O => 2-formylglutarate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41113", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695834", "l": "Constitutive phosphorylation of FLT3 mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211164", "l": "AKT phosphorylates FOXO1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48914", "l": "a ganglioside GT1a + CMP + H(+) => a ganglioside GD1a + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42338", "l": "[thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin] => [thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577244", "l": "MSH2 variant:MSH6-defective DNA mismatch repair (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097718", "l": "disordered domain specific binding", "d": ["Binding to a disordered domain of a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879909", "l": "Activation of STAT5a/b by JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9859148", "l": "BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.43", "l": "\"cathepsin V\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42196", "l": "(9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19684", "l": "ATP + biotin + CoA <=> AMP + biotinyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77046", "l": "5-hydroxyoctan-4-amine + H2O + NAD(+) <=> 5-hydroxyoctan-4-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975180", "l": "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018854", "l": "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity", "d": ["Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8865107", "l": "MICAL1 produces NADP+, H2O2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047421", "l": "N-acyl-D-glutamate deacylase activity", "d": ["Catalysis of the reaction: N-acyl-D-glutamate + H2O = D-glutamate + a carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9839073", "l": "HTRA2 binds NDUFA13 (GRIM-19) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29410", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 <=> 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26179", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine <=> 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190519", "l": "Internalization of gap junction plaques (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016761", "l": "cellulose synthase (GDP-forming) activity", "d": ["Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40728", "l": "1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid => a 1-acylglycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70063", "l": "a C28-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C28-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62258", "l": "Cd(2+)(in) + 2 hydrogencarbonate(in) => Cd(2+)(out) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76893", "l": "2-hydroxyacetophenone + H(+) + NADH + NH4(+) => 2-hydroxy-1-phenylethan-1-amine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166817", "l": "Cleavage of C3 by C3 convertases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59578", "l": "beta-alanine + N(pros)-methyl-L-histidine => anserine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69195", "l": "ATP + L-glutamate + L-glutamyl-[tubulin] <=> ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204824", "l": "Interaction of Tie2 and Ang4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446372", "l": "Association of  PARVA with TESK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54560", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP = a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429449", "l": "Syk activation leads to SLP-76 activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853921", "l": "VENTX stimulates p16-INK4A transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028273", "l": "PGH3 spontaneously dehydrates to PGJ3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66322", "l": "2',3'-cGAMP(in) => 2',3'-cGAMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15012", "l": "(6S)-5,6,7,8-tetrahydrofolate + NADP(+) <=> 7,8-dihydrofolate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046565", "l": "3-dehydroshikimate dehydratase activity", "d": ["Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013157", "l": "CDC42 binds effectors at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77068", "l": "Activation of GT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027631", "l": "5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78824", "l": "(3R)-5-guanidino-3-methyl-2-oxopentanoate + L-aspartate => (3R)-3-methyl-L-arginine + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33896", "l": "NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose => H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30739", "l": "1D-myo-inositol 3-phosphate + H2O = myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0048256", "l": "flap endonuclease activity", "d": ["Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3095889", "l": "MMACHC dealkylates RCbl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140903", "l": "histone H3R26 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 26) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 26). This reaction is the addition of a methyl group to the arginine residue at position 26 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66016", "l": "bromide + H2O2 = H2O + hypobromite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11032", "l": "(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate + H(+)", "d": [], "t": []}, {"i": "EC:5.5.1.7", "l": "\"chloromuconate cycloisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69528", "l": "chorismate + H2O + 2 L-glutamine = 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)", "d": [], "t": []}, {"i": "EC:2.6.1.123", "l": "\"4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31428", "l": "(2E,6E)-farnesyl diphosphate => (1S,5S,6R)-alpha-bergamotene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362450", "l": "Hh processing variants bind lectins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19374", "l": "H2O + L-saccharopine + NADP(+) => 2-oxoglutarate + H(+) + L-lysine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29836", "l": "D-galactonate(in) + H(+)(in) => D-galactonate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097620", "l": "(R)-mandelate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxy-2-phenylacetate + acceptor = phenylglyoxylate + reduced acceptor."], "t": []}, {"i": "RHEA:43112", "l": "(R)-mandelate + NAD(+) = H(+) + NADH + phenylglyoxylate", "d": [], "t": []}, {"i": "EC:1.1.1.379", "l": "\"(R)-mandelate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50555", "l": "prostaglandin C1 <=> prostaglandin B1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21548", "l": "H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] = acetate + L-lysyl-[alpha-tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814088", "l": "SYS1 binds AcM-ARFRP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49841", "l": "(-)-dehydrodiconiferyl acid + 2 a quinone + H2O => (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9866217", "l": "HCCS inserts heme into cytochrome c (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51751", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A <=> 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78514", "l": "a 5'-end (5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430190", "l": "p-SLP-76 binds NCK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64963", "l": "dTDP + H2O <=> dTMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800798", "l": "The PIDDosome binds CASP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17759", "l": "3-(methylsulfanyl)propanamine + CO2 => H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071906", "l": "CRD domain binding", "d": ["Binding to a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47644", "l": "adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140696", "l": "factor V -> factor Va + factor V activation peptide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51615", "l": "(R)-2-hydroxyglutarate + oxaloacetate <=> (R)-malate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507871", "l": "Aquaporins passively transport glycerol out of cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32339", "l": "(+)-thujan-3-ol + NADP(+) = (+)-thujan-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33174", "l": "D-maltose(in) <=> D-maltose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665989", "l": "DIAPH1 binds RHOA:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140791", "l": "histone H2AXS140 phosphatase activity", "d": ["Catalysis of the reaction: histone H2AX serine phosphate (position 140) + H2O = histone H2AX serine (position 140) + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008490", "l": "arsenite secondary active transmembrane transporter activity", "d": ["Enables the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659674", "l": "Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37119", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine = 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)", "d": [], "t": []}, {"i": "EC:2.3.1.231", "l": "\"tRNA(Phe) {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine(37)-N}-methoxycarbonyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44275", "l": "3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.357", "l": "\"3alpha-hydroxysteroid 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72548", "l": "2-oxoglutarate(in) + taurocholate(out) => 2-oxoglutarate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67936", "l": "a 2-hydroxy carboxylate + O2 = a 2-oxocarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627350", "l": "SMAC (DIABLO) binds XIAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29765", "l": "ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate => ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849646", "l": "SPINK5(490-624) binds KLK5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69792", "l": "D-phenylalanyl-tRNA(Phe) + H2O => D-phenylalanine + H(+) + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199404", "l": "CD40L binds CD40 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47987", "l": "H2O + presqualene diphosphate <=> diphosphate + hydroxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46905", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70596", "l": "GOT2 dimer deaminates L-Asp (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061929", "l": "gamma-glutamylaminecyclotransferase activity", "d": ["Catalysis of the reaction: epsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10582", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30414", "l": "benzoyl-CoA + benzyl alcohol <=> benzyl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30624", "l": "A + all-trans-neurosporene => AH2 + all-trans-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11986", "l": "A + H2O + testosterone acetate => AH2 + O2 + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78600", "l": "acetyl-CoA + octadecanoyl-CoA => 3-oxoeicosanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41109", "l": "2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34557", "l": "a 2-oxocarboxylate + H(+) + NADH => a (2S)-2-hydroxycarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426489", "l": "RISC binds inexactly matching target RNAs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18618", "l": "ATP + oxaloacetate => ADP + CO2 + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110311", "l": "POLZ extends translesion synthesis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928631", "l": "GIT1 binds bPIX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42167", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 <=> (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645598", "l": "RRAGC,D hydrolyzes GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83650", "l": "FasL:Fas binds FADD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011595", "l": "GSTZ1 dimer dehalogenates DCA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709831", "l": "HSP90 binds TBK1 and IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373738", "l": "Neurofascin interacts with syntenin-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.44", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27693", "l": "ATP + dGDP <=> ADP + dGTP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928624", "l": "EPHBs bind EFNBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44960", "l": "(2E)-decenoyl-CoA + H(+) + NADPH = decanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31111", "l": "acetyl-CoA + butanoyl-CoA = 3-oxohexanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66833", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + preasperterpenoid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14567", "l": "3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP] => (11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41906", "l": "(3R)-hydroxyhexadecanoyl-[ACP] + NADP(+) => 3-oxohexadecanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952128", "l": "RUNX3 binds TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49288", "l": "(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = AMP + diphosphate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}, {"i": "EC:6.3.1.20", "l": "\"lipoate--protein ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27712", "l": "ADP + GMP + H(+) => ATP + guanosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67683", "l": "a long-chain fatty acyl-CoA + H2O <=> a long-chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623705", "l": "Defective SLC12A3 does not cotransport Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78624", "l": "ATP + L-lysyl-5'-AMP => L-lysine + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5591086", "l": "SERPINA5 binds activated protein C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74787", "l": "L-histidyl-L-proline diketopiperazine(in) = L-histidyl-L-proline diketopiperazine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43822", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660663", "l": "Caspase-8 cleaves IL1B precursor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32748", "l": "ethanolamine(in) => ethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848864", "l": "PTK6 binds ARAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052739", "l": "phosphatidylserine 1-acylhydrolase activity", "d": ["Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13005", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine = H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.115", "l": "\"(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25043", "l": "L-selenocysteinyl-tRNA(Sec) + 2 phosphate => H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41513", "l": "L-ornithine + NADH + O2 => H2O + N(5)-hydroxy-L-ornithine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19814", "l": "a 2-oxocarboxylate + L-asparagine => 2-oxosuccinamate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22721", "l": "ATP + L-histidyl-[protein] => ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67828", "l": "a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20509", "l": "ATP + viomycin = ADP + H(+) + O-phosphoviomycin", "d": [], "t": []}, {"i": "EC:2.7.1.103", "l": "\"viomycin kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668714", "l": "RAC1:GTP binds NOX1 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63520", "l": "2-isopropylphenol + H(+) + NADH + O2 = 3-isopropylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662596", "l": "MT1F binds cadmium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16280", "l": "H2O + indole-3-acetaldehyde + O2 <=> (indol-3-yl)acetate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32833", "l": "an R-cob(III)alamin(out) => an R-cob(III)alamin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74448", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418451", "l": "cGMP stimulates Protein Kinase G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25925", "l": "A + H2O + quinolin-8-ol => 8-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31135", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate = 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40652", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67946", "l": "2-oxohexadecanoate + H2O2 => 2-hydroxyhexadecanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43685", "l": "ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate => AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70464", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2 => a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449829", "l": "IL11 binds IL11RA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17828", "l": "ATP + D-glucose <=> ADP + D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045152", "l": "antisigma factor binding", "d": ["Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9022314", "l": "HIPK2 phosphorylates MECP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75560", "l": "erinacol + O2 + reduced [NADPH--hemoprotein reductase] => cyathadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63101", "l": "H(+) + ilicicolin C + NADPH + O2 => ascochlorin + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22581", "l": "(S)-4-hydroxy-2-oxopentanoate => (2Z)-2-hydroxypenta-2,4-dienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20739", "l": "acetyl-CoA + glycine <=> (2S)-2-amino-3-oxobutanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448744", "l": "IL20RA binds IL20RB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49154", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine => dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58739", "l": "H2O + TTP <=> 5-methyl-UMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45366", "l": "(11Z)-eicosenoate + (4R)-hydroxysphinganine => H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948524", "l": "PTENP1 mRNA binds miR-19b RISC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50240", "l": "[hyaluronan](n) = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O", "d": [], "t": []}, {"i": "EC:4.2.2.1", "l": "\"hyaluronate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71263", "l": "chloride(out) + L-proline(out) + 2 Na(+)(out) = chloride(in) + L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034780", "l": "glyphosate dehydrogenase activity", "d": ["Catalysis of the reaction: glyphosate + OH- = glyoxylate + aminomethylphosphonic acid + H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31782", "l": "an all-trans-retinyl ester + H2O <=> 13-cis-retinol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65441", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0004844", "l": "uracil DNA N-glycosylase activity", "d": ["Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77570", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol <=> 1,3-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57262", "l": "GDP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38958", "l": "an N-acylsphing-4-enine 1-phosphate(in) <=> an N-acylsphing-4-enine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38666", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54470", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + octanoate => 1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015451", "l": "decarboxylation-driven active transmembrane transporter activity", "d": ["Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018706", "l": "pyrogallol hydroxytransferase activity", "d": ["Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37447", "l": "O2 + tetracenomycin F1 = H(+) + H2O + tetracenomycin D3", "d": [], "t": []}, {"i": "EC:1.13.12.21", "l": "\"tetracenomycin-F1 monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050144", "l": "nucleoside deoxyribosyltransferase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944261", "l": "Association of procollagen type XIII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0017176", "l": "phosphatidylinositol N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25486", "l": "(1S,4R)-camphene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665998", "l": "MKL1 binds SRF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41560", "l": "(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 = (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.15", "l": "\"(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625482", "l": "PTK2 binds activated EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097641", "l": "alpha-ketoglutarate-dependent xanthine dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate (alpha-ketoglutarate) + O2 + xanthine = CO2 + succinate + urate."], "t": []}, {"i": "RHEA:43120", "l": "2-oxoglutarate + O2 + xanthine = CO2 + succinate + urate", "d": [], "t": []}, {"i": "EC:1.14.11.48", "l": "\"xanthine dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39653", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + H(+) => 6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20334", "l": "ATP + L-seryl-[acetyl-CoA carboxylase] => ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.31", "l": "\"ananain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0016699", "l": "oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein."], "t": []}, {"i": "EC:1.12.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641134", "l": "SMURF2 binds AXIN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72654", "l": "1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2 <=> 1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634861", "l": "NPAS4 binds ARNT2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211924", "l": "CYP4B1 12-hydroxylates ARA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59161", "l": "ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] => AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757686", "l": "SERPINA6 binds PREDL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1236970", "l": "Proteasomal clevage of exogenous antigen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14447", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9846332", "l": "FUT1,2 transfer fucose to gangliosides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033915", "l": "mannan 1,2-(1,3)-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of (1->2) and (1->3) linkages in mannan, releasing mannose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183052", "l": "CBL binds to GRB2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11443", "l": "2,3,5,6-tetrachlorophenol + NADPH + O2 <=> 2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5631941", "l": "SESN1,2,3 bind AMPK (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376851", "l": "SLC25A11 exchanges 2-OG and MAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4647594", "l": "SAHF formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374899", "l": "Release of noradrenaline  at the synapse (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.48", "l": "\"heme oxygenase (staphylobilin-producing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74419", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64396", "l": "glycyl-sarcosine(out) + H(+)(out) = glycyl-sarcosine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610408", "l": "GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692135", "l": "SOX9, NR5A1 (SF1), and GATA4 bind the AMH gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61355", "l": "ATP + H2O + riboflavin(in) <=> ADP + H(+) + phosphate + riboflavin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13157", "l": "(R)-glycerate + CO2 + NADP(+) = 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018652", "l": "toluene-sulfonate methyl-monooxygenase activity", "d": ["Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018727", "l": "2-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.6", "l": "\"leucine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022809", "l": "mobile ion carrier activity", "d": ["Small molecule produced by bacteria that carries an ion across the membrane by enclosing the ion and travelling with the ion across the membrane. It does not form a fully open pore across the membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985943", "l": "p-Y701-STAT1 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62710", "l": "4-(indol-3-yl)butanoyl-beta-D-glucose + UDP => (indol-3-yl)butanoate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199154", "l": "CD200 binds to CD200R (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41989", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138459", "l": "WNT5A:FZD4 is endocytosed (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8980691", "l": "RHOA GEFs activate RHOA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35664", "l": "a 1,2-diacyl-sn-glycerol + H2O => a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64801", "l": "NAD(+) + S-(2-aminoethyl)-L-cysteine => (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58997", "l": "H2O + indole-3-carbaldehyde + O2 => H(+) + H2O2 + indole-3-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848774", "l": "PTK6 binds DOK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341294", "l": "Superoxide reduces cytochrome c (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321918", "l": "Defective MTR does not transfer CH3 group from MTHF to cob(I)alamin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17315", "l": "AMP + diphosphate + H(+) + L-histidyl-tRNA(His) => ATP + L-histidine + tRNA(His)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034834", "l": "2-mercaptobenzothiazole dioxygenase activity", "d": ["Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52542", "l": "alpha-D-ribose 1-phosphate + cytosine => cytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41023", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42273", "l": "3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] => 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43858", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66215", "l": "asc-omegaC5-CoA + O2 <=> asc-omegaDeltaC5-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51413", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008267", "l": "ESR1 binds to TGFA gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39374", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54353", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5681980", "l": "ATG12 binds ATG7 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73761", "l": "2'-O-methylguanosine(2553) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2553) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21285", "l": "all-trans-retinol + NAD(+) => all-trans-retinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56085", "l": "[Rab1 protein]-O-phosphocholine-L-serine + H2O => [Rab1 protein]-L-serine + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14352", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose <=> an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005521", "l": "lamin binding", "d": ["Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37003", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65862", "l": "17beta-hydroxyandrostan-1,3-dione + AH2 => A + Delta(1)-dihydrotestosterone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67953", "l": "an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53412", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 = (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52075", "l": "12-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74713", "l": "5-dehydrofumagillol + H(+) + S-adenosyl-L-homocysteine => 5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026891", "l": "NTRK2 activates RAS signaling through SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47383", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37401", "l": "1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0001054", "l": "RNA polymerase I activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700131", "l": "ALK mutants bind type I TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53158", "l": "H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47899", "l": "6-sulfo-D-quinovose + NAD(+) <=> 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38422", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O <=> 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65025", "l": "7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) => dehydrocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.4", "l": "\"malate dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11401", "l": "GDP-6-deoxy-alpha-D-altrose + sordaricin => 4'-O-demethylsordarin + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10256", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": [], "t": []}, {"i": "EC:2.7.9.5", "l": "\"phosphoglucan, water dikinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.-.-.-", "l": "\"Oxidoreductases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60523", "l": "2 H2O + L-cystine-bis-glycine <=> 2 glycine + L-cystine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36309", "l": "3,4-dihydroxybenzaldehyde + acetyl-CoA => (E)-caffeoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044667", "l": "(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (R)-carnitine(out) + 4-(trimethylammonio)butanoate(in) = (R)-carnitine(in) + 4-(trimethylammonio)butanoate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839388", "l": "TGFBR3 translocation to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32022", "l": "(2E,6E)-farnesyl diphosphate <=> beta-cubebene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53873", "l": "CTP + D-ribose 5-phosphate + H(+) => CDP-D-ribose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42133", "l": "isonocardicin C => nocardicin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62039", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156930", "l": "GTP-binding activates eEF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-376851", "l": "SLC25A11 exchanges 2-OG and MAL (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56973", "l": "(R)-3-hydroxy-2-methylpropanoate + NAD(+) => (R)-2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64768", "l": "S-3-(hexan-1-ol)-L-cysteine = 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.11", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.87", "l": "\"aralkylamine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77127", "l": "1D-myo-inositol 1,2,3-trisphosphate + H2O = 1D-myo-inositol 2,3-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61578", "l": "(3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH => (4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63480", "l": "NADP(+) + prostaglandin F2alpha = 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000327", "l": "PLK1 phosphorylates BORA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012268", "l": "ME2 tetramer decarboxylates MAL to PYR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29763", "l": "ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32392", "l": "(1R,2R,4R)-dihydrocarveol + NAD(+) => (1R,4R)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48939", "l": "2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25853", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55758", "l": "a 2-hydroxyornithine lipid + CO2 + succinate => 2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52093", "l": "5-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004466", "l": "long-chain fatty acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: a long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79092", "l": "an L-alpha-amino acid + taurocholate => an N-choloyl-L-alpha-amino acid + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395992", "l": "p-T,4S-IRF3 is dimerized (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38494", "l": "2-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50385", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline => 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59184", "l": "2,4-diacetylphloroglucinol + H2O = 2-acetylphloroglucinol + acetate", "d": [], "t": []}, {"i": "EC:3.7.1.24", "l": "\"2,4-diacetylphloroglucinol hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018762", "l": "aliphatic nitrilase activity", "d": ["Catalysis of the reaction: R-CN + H2O = R-COOH + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686699", "l": "Fusion and Release of SARS-CoV-1 Nucleocapsid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16335", "l": "diphosphate + holo-[citrate lyase ACP] => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50620", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.343", "l": "\"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35706", "l": "1'-hydroxyversicolorone + H(+) + NADPH + O2 <=> (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18200", "l": "N-cyclohexylformamide <=> cyclohexyl isocyanide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103040", "l": "aldose sugar dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + an aldose + an oxidized electron acceptor = H+ + an aldonate + a reduced electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055131", "l": "C3HC4-type RING finger domain binding", "d": ["Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9853512", "l": "DLST transfers succinyl to CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49043", "l": "(-)-5'-demethylyatein + S-adenosyl-L-methionine <=> (-)-yatein + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46715", "l": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48907", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29824", "l": "chloride(in) => chloride(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71573", "l": "5-aminoethoxy-methyl-dUMP in DNA + CO2 => 5-O-(L-seryl)-dTMP in DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672329", "l": "IQGAP1 binds CLIP1 and microtubules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390598", "l": "Myosin Binds ATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14093", "l": "2-oxoglutarate + L-tryptophan = indole-3-pyruvate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.27", "l": "\"tryptophan transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.35", "l": "\"CRIK-subfamily protein kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149519", "l": "MMACHC decyanates CNCbl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876484", "l": "NPC2 transfers CHOL to NPC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671873", "l": "Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654422", "l": "Activated FGFR4 binds FRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730892", "l": "Recruitment of VAV to p-SLP-76 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38342", "l": "(20S)-ginsenoside Rb1 + H2O <=> (20S)-ginsenoside Rd + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54135", "l": "a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate <=> a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10005", "l": "benzyl isothiocyanate => benzyl thiocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27928", "l": "UMP(out) => UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33822", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate <=> 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9634861", "l": "NPAS4 binds ARNT2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730835", "l": "Autophosphorylation of PKC-theta (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140804", "l": "NAD+- protein-lysine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + NAD+ = H+ + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:58220", "l": "L-lysyl-[protein] + NAD(+) = H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3318415", "l": "ATF2 acetylates histone H2B, H4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28902", "l": "glycine(in) + H(+)(in) <=> glycine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28487", "l": "Fe(2+)(in) => Fe(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20594", "l": "H2O + N-acetyl-D-glucosamine => acetate + D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68602", "l": "3-oxopropane-1-sulfonate + H2O => (2S)-3-sulfopropanediol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77254", "l": "[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-3-O-methyl-D-mannose + GDP-alpha-D-mannose <=> alpha-D-mannosyl-(1->4)-[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-3-O-methyl-D-mannose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74375", "l": "H2O2(out) = H2O2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23455", "l": "2'-deoxyadenosine + ATP <=> ADP + dAMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10326", "l": "a 2-hydroxycarbonyl + H(+) + NADPH => an L-glycol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23088", "l": "ATP + O-alkylglycerone = 1-O-alkylglycerone 3-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.84", "l": "\"alkylglycerone kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9611751", "l": "β1,2-agonists bind ADRB1,2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40583", "l": "H2O + hexanedioyl-CoA = CoA + H(+) + hexanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74985", "l": "(3R)-3-isocyanylbutanoyl-[ACP] + AMP + H(+) => (3R)-3-isocyanylbutanoyl-AMP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2534096", "l": "METAP1/2 demethylates GNAT1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28212", "l": "(S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate => H2O + L-saccharopine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60010", "l": "a tRNA with a 3' CC end + 2 diphosphate => a tRNA precursor + 2 CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680242", "l": "Ligand-independent dimerization of KIT extracellular domain mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54824", "l": "H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] = alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": [], "t": []}, {"i": "EC:3.2.1.130", "l": "\"glycoprotein endo-alpha-1,2-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0045183", "l": "translation factor activity, non-nucleic acid binding", "d": ["A translation regulator activity that does not involve binding to nucleic acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29939", "l": "H(+)(in) + phosphate(in) = H(+)(out) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36352", "l": "AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine => 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65282", "l": "3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+) => 3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17562", "l": "acetylcholine + H2O => acetate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30050", "l": "chloroacetaldehyde + H2O + NAD(+) <=> chloroacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19397", "l": "(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": [], "t": []}, {"i": "EC:6.3.2.5", "l": "\"phosphopantothenate--cysteine ligase (CTP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63327", "l": "1,2-dihexadecanoyl-sn-glycerol + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.1", "l": "\"hexokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984606", "l": "Kinesin-5 is a homotetramer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17856", "l": "keto-L-sorbose + O2 <=> 5-dehydro-D-fructose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.156", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78352", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41020", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol => 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72921", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II => 4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070448", "l": "laricitrin 5'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9612501", "l": "SGK phosphorylates CREB1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032395", "l": "MHC class II receptor activity", "d": ["Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098626", "l": "methylseleninic acid reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + CH3SeO2H => NADP+ + CH3SeOH + H2O."], "t": []}, {"i": "REACT:R-HSA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23861", "l": "acetyl-CoA + deacetylcephalosporin C => cephalosporin C + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113429", "l": "Elongating transcript encounters a lesion in the template (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202702", "l": "CD177 binds PECAM-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50795", "l": "18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> aldosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30597", "l": "3,4-dihydroxyphenylacetate + FAD + H(+) + H2O => 4-hydroxyphenylacetate + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72708", "l": "GDP-beta-L-fucose(in) + GMP(out) => GDP-beta-L-fucose(out) + GMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11029", "l": "ATP + D-mannose => ADP + D-mannose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5622129", "l": "FABP5 binds atRA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79122", "l": "glycocholate + L-arginine <=> glycine + L-arginocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65304", "l": "2-oxoglutarate + O2 + verruculide A = chrodrimanin T + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.7", "l": "\"inulinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72661", "l": "8-hydroxyquinoline N-oxide + H2O + NADP(+) => NADPH + O2 + quinolin-8-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70285", "l": "4-acetamidobutanal + H2O2 + NH4(+) => H2O + N-acetylputrescine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047870", "l": "discadenine synthase activity", "d": ["Catalysis of the reaction: N(6)-dimethylallyladenine + S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + discadenine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54047", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 7-epi-alpha-eudesmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66927", "l": "[(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA <=> [(R)-3-hydroxyalkanoate](n+1) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62336", "l": "AMP + ATP = adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592436", "l": "Initial activation of proMMP9 by MMPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678128", "l": "Spike glycoprotein of SARS coronavirus binds ACE2 on host cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45711", "l": "3-dehydrocarnitine + acetyl-CoA <=> 3-dehydrocarnityl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68927", "l": "ATP + H(+) + hexanoate + NADPH <=> AMP + diphosphate + hexanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78217", "l": "2-oxoglutaramate + H2O2 + NH4(+) => D-glutamine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77951", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate = 1-(9Z-octadecenoyl)-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63929", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102381", "l": "stevioside glucosyltransferase activity (rebaudioside A forming)", "d": ["Catalysis of the reaction: stevioside + UDP-alpha-D-glucose = rebaudioside A + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022770", "l": "MECP2 binds SGK1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295622", "l": "SPRY2 binds CBL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11703", "l": "H(+) + NADPH + O2 + progesterone <=> H2O + NADP(+) + testosterone acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16730", "l": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) => catechol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57077", "l": "3-oxoisoapionate 4-phosphate + H2O => (2R)-3-phosphoglycerate + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353271", "l": "Cleavage of uracil by Uracil-glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58721", "l": "(S)-nicotine + NADPH + O2 => H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45134", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679775", "l": "COMT binds COMT Inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68486", "l": "CO2 + H2O + undecanal => (2R)-2-hydroperoxydodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32474", "l": "demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] <=> (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51956", "l": "(E)-2-methylpropanal oxime = (Z)-2-methylpropanal oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667914", "l": "ALK binds ligand midkine (MDK) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.32", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75847", "l": "9-cis-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48521", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38816", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008453", "l": "alanine-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50779", "l": "hexanal + NADP(+) <=> (E)-hex-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37419", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42670", "l": "H(+) + L-rhamnono-1,4-lactone + NADPH => L-rhamnofuranose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22639", "l": "dCTP + H2O <=> dCMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49118", "l": "deoxyviolaceinate + H2O + NADP(+) => H(+) + NADPH + O2 + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32444", "l": "all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.131", "l": "\"carotenoid 1,2-hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795667", "l": "MDM2 translocates to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19092", "l": "S-adenosyl-L-methionine + uroporphyrinogen III <=> H(+) + precorrin-1 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627106", "l": "SMAC (DIABLO) forms dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209210", "l": "STAT92E is phosphorylated by phosphorylated HOP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708866", "l": "pro-F2R binds vorapaxar (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72002", "l": "O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937989", "l": "RUNX1 binds PRC1 complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22744", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.62", "l": "\"mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450027", "l": "Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48346", "l": "a D-galactosylceramide + H(+) + UDP => an N-acyl-sphingoid base + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222346", "l": "AhpC reduces H2O2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111264", "l": "Addition of nucleotides between position +11 and +30 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57610", "l": "3-chlorocatechol + H(+) + NADH => (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951500", "l": "Dissociation of CANX from nonameric complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692749", "l": "CDC14A,B bind MAPK6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12509", "l": "loganate + S-adenosyl-L-methionine => loganin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74367", "l": "substance P(out) = substance P(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28817", "l": "4-hydroxybenzoate(out) + H(+)(in) => 4-hydroxybenzoate(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48950", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106614", "l": "Duplex miRNA is loaded into Argonaute (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71897", "l": "H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide => dGTP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928645", "l": "EPHB:NMDAR binds TIAM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418549", "l": "PKG1 phosphorylates BK channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983425", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53952", "l": "4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate = 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5631941", "l": "SESN1,2,3 bind AMPK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814764", "l": "Plasma membrane resorption (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799466", "l": "TP53I3 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35435", "l": "cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose = cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.50", "l": "\"cyanidin 3-O-galactoside 2''-O-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46627", "l": "a D-5-monosubstituted hydantoin <=> a L-5-monosubstituted hydantoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130504", "l": "Cleavage of lip22 to lip10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692809", "l": "CDC42 binds effectors at the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204798", "l": "Interaction of Tie2 and p85 of PI3K (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045442", "l": "deacetoxycephalosporin-C hydroxylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + deacetoxycephalosporin C + O2 = CO2 + deacetylcephalosporin C + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026757", "l": "GGT hydrolyses MCTR1 to MCTR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010491", "l": "UTP:arabinose-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160149", "l": "tRNA pseudouridine(65) synthase activity", "d": ["Catalysis of the reaction: uridine(65) in tRNA = pseudouridine(65) in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14018", "l": "ATP + beta-nicotinamide D-riboside => ADP + beta-nicotinamide D-ribonucleotide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62808", "l": "H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56718", "l": "H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate => H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34928", "l": "H(+) + NADPH + selenodiglutathione => glutathione + glutathioselenol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61324", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029456", "l": "RAC1 and CDC42 activate PAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13448", "l": "(R)-pantetheine + H2O <=> (R)-pantothenate + cysteamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19213", "l": "acetyl-CoA + an S-substituted L-cysteine = an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.80", "l": "\"cysteine-S-conjugate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73196", "l": "malonate(in) + sulfate(out) => malonate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034482", "l": "chondroitin 2-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 2'-O-sulfate. Results in sulfation of glucuronic acid and iduronic acid residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45617", "l": "H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0015112", "l": "nitrate transmembrane transporter activity", "d": ["Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other."], "t": []}, {"i": "RHEA:34923", "l": "nitrate(in) = nitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39972", "l": "1-aminocyclopropane-1-carboxylate => 2-aminobut-2-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53836", "l": "a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34485", "l": "4-hydroxybenzalacetone + 2 CO2 + 2 CoA => 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51147", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 <=> (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018772", "l": "trioxoheptanoate hydrolase activity", "d": ["Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759158", "l": "SQSTM1 oligomerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74711", "l": "Phosphorylation of IRS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751013", "l": "Inactive G alpha (s) reassociates with G beta:gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44984", "l": "(R)-carnitine + 3-methylbutanoyl-CoA = CoA + O-3-methylbutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73383", "l": "thiamine diphosphate(in) + thiamine phosphate(out) = thiamine diphosphate(out) + thiamine phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38736", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909724", "l": "Recruitment of IFNAR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62845", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose => beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71155", "l": "TAT deaminates tyrosine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016971", "l": "flavin-dependent sulfhydryl oxidase activity", "d": ["Catalysis of the reaction: [protein]-dithiol + O2 = [protein]-disulfide + H2O2 using FAD as a cofactor, leading to formation of disulfide bridges in proteins."], "t": []}, {"i": "RHEA:59116", "l": "[protein]-dithiol + O2 = [protein]-disulfide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76757", "l": "1,3-decanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => decan-1-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45227", "l": "(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA <=> (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43630", "l": "aminoacetaldehyde + CO2 + NADH => L-serine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72663", "l": "De novo formation of eIF2:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56979", "l": "4-methylphenol + H2O + 2 oxidized [azurin] <=> 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170008", "l": "mRNA phosphatase activator activity", "d": ["Binds to and increases the activity of mRNA phosphatase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78419", "l": "H(+) + N-(1H-1,3-benzodiazol-2-yl)carbamate = 2-aminobenzimidazole + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38566", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + H2O <=> 1-O-hexadecyl-sn-glycerol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64665", "l": "a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54912", "l": "11-cis-retinol + NADP(+) = 11-cis-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982775", "l": "Growth hormone receptor dimerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16194", "l": "an (R)-2-haloacid + H2O => a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351894", "l": "Caspase mediated cleavage of BAP31 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912727", "l": "CBL binds VAV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015434", "l": "ABC-type cadmium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47443", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) <=> 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853745", "l": "RET binds GFRA1,GFRA3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-874087", "l": "SGT1 binds HSP90 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021079", "l": "PalmS-ESRs:CAVs translocate to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160010", "l": "protein de-2-hydroxyisobutyrylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]."], "t": []}, {"i": "RHEA:69176", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696997", "l": "USP24 deubiquitinates DDB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821410", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668545", "l": "NIK autophosphorylates on T559 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76016", "l": "(3R)-hydroxybutanoate trimer + H2O => (3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11008", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362485", "l": "GHBP binds GH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39190", "l": "(3R)-hydroxydocosanoyl-CoA <=> (2E)-docosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0005308", "l": "creatine transmembrane transporter activity", "d": ["Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29506", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + patchoulol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18168", "l": "biphenyl + H(+) + NADH + O2 <=> (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693598", "l": "ATM phosphorylates NBN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813740", "l": "GDE1 hydrolyzes GroPIns (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62242", "l": "a thymine-cytidine dinucleotide in DNA => a thymidine(6-4)cytidine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56993", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => (+)-costunolide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53000", "l": "17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58338", "l": "a 4-hydroxynonenal + H(+) + NADPH => a 4-hydroxynonen-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31564", "l": "H2O + leukotriene C4 => L-glutamate + leukotriene D4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51952", "l": "(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44048", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10441", "l": "D-glucono-1,5-lactone + H2O => D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034557", "l": "2-hydroxylaminobenzoate reductase activity", "d": ["Catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44444", "l": "a 1,2-diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198314", "l": "DAG stimulates protein kinase C-delta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72555", "l": "estrone 3-sulfate(out) + propanoate(in) = estrone 3-sulfate(in) + propanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49184", "l": "chlorophyllide a + H(+) + H2O = 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol", "d": [], "t": []}, {"i": "EC:3.1.1.100", "l": "\"chlorophyllide a hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62134", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + dTDP => a 2'-deoxyribonucleoside 5'-phosphate + dTTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611751", "l": "β1,2-agonists bind ADRB1,2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451895", "l": "IL2RG binds JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964619", "l": "PAK1 binds ARHGEF6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54747", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13805", "l": "A + a 3-oxo-5alpha-steroid = a 3-oxo-Delta(4)-steroid + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787820", "l": "IL34 dimer binds CSF1R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62802", "l": "2 H2O + NADP(+) + orlandin => 2 7-demethylsiderin + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27764", "l": "CMP + diphosphate + H(+) => CTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830765", "l": "Expression of GDNF in metanephric mesenchyme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30458", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O <=> (-)-geosmin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050005", "l": "isohexenylglutaconyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23273", "l": "an N(6)-alkylaminopurine + UDP-alpha-D-glucose => an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667619", "l": "AVPR1A,B,2 bind atosiban (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36103", "l": "anthranilate + S-adenosyl-L-methionine = O-methyl anthranilate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.277", "l": "\"anthranilate O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64662", "l": "a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30734", "l": "butanoyl-CoA + FAD + H(+) <=> (2E)-butenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373747", "l": "Phosphorylation of nephrin by FYN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9821368", "l": "AKAP8L binds MLL1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46082", "l": "NAD(+) + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27706", "l": "ATP + D-alanine + D-serine = ADP + D-alanyl-D-serine + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.35", "l": "\"D-alanine--D-serine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68313", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O => 1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26314", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate => dihydroxyacetone phosphate + L-aspartate 4-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876868", "l": "ECE1 cleaves EDN1(53-90) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35567", "l": "H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine = (9Z,12Z)-octadecadienoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76726", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627369", "l": "SEPT4 binds XIAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865605", "l": "BRWD1 binds SMARCA4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48239", "l": "2 2-acetylphloroglucinol <=> 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247840", "l": "WLS binds WNT ligands in the Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809521", "l": "BPIF binds bacteria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67043", "l": "(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+) <=> asnovolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050464", "l": "nitrate reductase (NADPH) activity", "d": ["Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651789", "l": "LIG1 bound to POLB ligates SSB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70506", "l": "H2O + isopentenyl diphosphate <=> H(+) + isopentenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706336", "l": "Active FLT3 binds to SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0003779", "l": "actin binding", "d": ["Binding to monomeric or multimeric forms of actin, including actin filaments."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005164", "l": "tumor necrosis factor receptor binding", "d": ["Binding to a tumor necrosis factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77377", "l": "CO2 + hexadecane => H(+) + heptadecanoate + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38034", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) <=> (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0051536", "l": "iron-sulfur cluster binding", "d": ["Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016041", "l": "glutamate synthase (ferredoxin) activity", "d": ["Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62699", "l": "O2 + 4 tellimagrandin II <=> 2 cornusiin E + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0003882", "l": "CDP-diacylglycerol-serine O-phosphatidyltransferase activity", "d": ["Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102903", "l": "gamma-terpinene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = gamma-terpinene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55962", "l": "4-(trimethylamino)butanoyl-CoA + AMP + diphosphate => 4-(trimethylamino)butanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31768", "l": "2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine => L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16908", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160039", "l": "serotonin-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when the biogenic amine serotonin has been bound by the channel complex or one of its constituent parts. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74290", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA <=> an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52152", "l": "(Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose = (Z)-indolylmethyl desulfoglucosinolate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204169", "l": "PDP1,2 dephosphorylate p-lipo-PDH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50777", "l": "hexanal + NADP(+) => (E)-hex-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31279", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60672", "l": "NAD(+) + nerol = H(+) + NADH + neral", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9824977", "l": "MAPK1-dependent phosphorylation of MITF-M (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592398", "l": "Activation of proMMP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48252", "l": "a ganglioside GD2 + UDP-alpha-D-galactose = a ganglioside GD1b + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804253", "l": "MDM2 ubiquitinates JMY (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38862", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13051", "l": "D-fructuronate => D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70290", "l": "1D-myo-inositol 3,4,6-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61162", "l": "H(+) + quercitrin + UDP => quercetin + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35141", "l": "CO2 + 2 CoA + demethoxycurcumin => (E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9858590", "l": "DLST transfers glutaryl to CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400382", "l": "CSNK1E,CSNK1D phosphorylate CRY and PER proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50079", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853496", "l": "SCF:FBXL7 binds AURKA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68749", "l": "alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein] => alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47282", "l": "4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76590", "l": "(6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + 2-oxoglutarate + AH2 + H(+) + O2 <=> (2S)-5,5-dimethylpiperidine-2-carboxylate + A + 2 CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210439", "l": "glutamate uptake by astrocytes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45621", "l": "H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73554", "l": "GDP(out) + UTP(in) <=> GDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693125", "l": "RHOF binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52215", "l": "acetochlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ethyl formate + H2O + N-(2-ethyl-6-methylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27472", "l": "H2O + N,N'-diacetylchitobiose <=> acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51203", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine <=> H2O + N-retinylidene-N-retinylphosphatidylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72333", "l": "3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => 3-hydroxy-4-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392749", "l": "Transport of L1 into endosomes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70804", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate => 4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14980", "l": "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate <=> 3-carboxy-cis,cis-muconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61482", "l": "an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+) => a sphingoid base + a very long-chain fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75818", "l": "ATP + H2O + K(+)(in) <=> ADP + H(+) + K(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68210", "l": "1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA => (7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28890", "l": "H(+)(in) + L-serine(in) <=> H(+)(out) + L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010648", "l": "ROBO2 binds AKAP5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10906", "l": "AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide => [cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53883", "l": "ADP-alpha-D-glucose + D-glucose 6-phosphate <=> ADP + alpha,alpha-trehalose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22478", "l": "4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH => 4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.60", "l": "\"protein geranylgeranyltransferase type II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38270", "l": "2-methylfumaryl-CoA <=> 3-methylfumaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24628", "l": "2 H2O + 3 NAD(+) + NH4(+) = 5 H(+) + 3 NADH + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49322", "l": "(5R,6S)-5,6-epoxi-capsanthin => all-trans-violaxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41174", "l": "1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O <=> 2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55640", "l": "C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42894", "l": "5'-deoxyinosine + NH4(+) => 5'-deoxyadenosine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71148", "l": "3-hydroxyhispidin + O2 => 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20861", "l": "(1S,6R)-isopiperitenol + NAD(+) => (6R)-isopiperitenone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20720", "l": "H2O + isopenicillin N + phenylacetyl-CoA = CoA + H(+) + L-2-aminoadipate + penicillin G", "d": [], "t": []}, {"i": "EC:2.3.1.164", "l": "\"isopenicillin-N N-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.156", "l": "\"adenosylcobinamide kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709317", "l": "CO binds to free ferrohemoglobin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818578", "l": "Cleaved KMT2B dimers translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607721", "l": "Activation of NIK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.923250621671642", "identifiers": [{"i": "GO:0004843", "l": "cysteine-type deubiquitinase activity", "d": ["An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686663", "l": "Completion of SSA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29321", "l": "ethanolamine + H(+) + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79014", "l": "ent-copalyl diphosphate <=> diphosphate + ent-beyerene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082391", "l": "Trimerization of HSF1 in the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71633", "l": "phosphate(out) + sulfate(in) => phosphate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5220959", "l": "TDG excises 5-formylcytosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30748", "l": "FAD + H(+) + hexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791116", "l": "Expression of DDX11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052881", "l": "4-hydroxyphenylacetate 3-monooxygenase activity", "d": ["Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O2 = 3,4-dihydroxyphenylacetate + FAD + H+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637764", "l": "Binding of GRB2:GAB1 complex to p-EGFRvIII mutant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37952", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.65", "l": "\"thermomycolin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9675026", "l": "Formation of the MLL1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985594", "l": "MYO9B inactivates RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76116", "l": "2-oxoglutarate + O2 + thebaine => 6-O-demethylthebaine + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30479", "l": "L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009011", "l": "starch synthase activity", "d": ["Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809309", "l": "MTMR6 binds MTMR9 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28165", "l": "cytidine + GTP <=> CMP + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9854368", "l": "ROS,RNS oxidize ACO2:4Fe-4S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68283", "l": "L-seryl-[protein] + pentanoyl-CoA <=> CoA + O-pentanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74066", "l": "2-aminoisobutanoate(out) + L-alanine(in) <=> 2-aminoisobutanoate(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14613", "l": "ATP + H2O + taurine(out) = ADP + H(+) + phosphate + taurine(in)", "d": [], "t": []}, {"i": "EC:7.6.2.7", "l": "\"ABC-type taurine transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450551", "l": "AUF1 binds translation and heat shock proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65325", "l": "acetyl-CoA + chrodrimanin A => chrodrimanin B + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54733", "l": "N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23565", "l": "2 columbamine + O2 => 2 berberine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983194", "l": "Kinesin-1 is a heterotetramer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35654", "l": "(4R)-hydroxysphinganine + a fatty acyl-CoA <=> an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018722", "l": "1-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n4", "l": "\"(-)-trans-carveol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030732", "l": "methionine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187506", "l": "Translocation of p27 to the nucleoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984671", "l": "Chromokinesins form dimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166038", "l": "GPI-bound CD14 binds LPS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57355", "l": "O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin <=> H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052635", "l": "C-20 gibberellin 2-beta-dioxygenase activity", "d": ["Catalysis of the reaction: a C-20 gibberellin + 2-oxoglutarate + O2 = a C-20 2-beta-hydroxygibberellin + succinate + CO2. C-20 gibberellin refers to a gibberellin with twenty carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10067", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49500", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725315", "l": "ALK-stimulated MYCN gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14182", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 => (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940309", "l": "Expression of PERM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0070548", "l": "L-glutamine aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67804", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2 = CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419049", "l": "ROCK activation by RHO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38980", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64674", "l": "butyl 2-(methylsulfanyl)acetate + CoA => 2-(methylsulfanyl)acetyl-CoA + butan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706837", "l": "AR binds AR antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102436", "l": "7-methylmyricetin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 7-O-methylmyricetin + S-adenosyl-L-methionine = 7,4'-dimethylmyricetin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0001640", "l": "adenylate cyclase inhibiting G protein-coupled glutamate receptor activity", "d": ["Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665311", "l": "ERBB2 T798M does not bind afatinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69928", "l": "adenosine(out) + Na(+)(out) => adenosine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848751", "l": "PTK6 binds AKT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102891", "l": "2'4'6'34-pentahydroxychalcone 4'-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 2',3,4,4',6'-pentahydroxychalcone = H+ + 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52171", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73694", "l": "3'-AMP(out) + phosphate(in) <=> 3'-AMP(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934819", "l": "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46874", "l": "a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71166", "l": "H(+)(in) + L-alanine(out) + Na(+)(out) <=> H(+)(out) + L-alanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044377", "l": "RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050546", "l": "4-hydroxyphenylpyruvate decarboxylase activity", "d": ["Catalysis of the reaction: (4-hydroxyphenyl)pyruvate + H+ = (4-hydroxyphenyl)acetaldehyde + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69747", "l": "(indol-3-yl)acetate + succinyl-CoA = (indol-3-yl)acetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654163", "l": "Activated FGFR4 binds PLCG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68938", "l": "AMP + diphosphate + NADP(+) + nonanal => ATP + H(+) + NADPH + nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33370", "l": "D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-glucose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389083", "l": "Autophosphorylation of PDGF alpha receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27824", "l": "acetate + L-homocysteine => hydrogen sulfide + O-acetyl-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445448", "l": "HHIP binds Hedgehog (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41694", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+) => 1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30535", "l": "biotinate sulfoxide + H(+) + NADPH = biotin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429732", "l": "Multiphospho-CERT1-2 binds PPM1L, VAPA/B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693148", "l": "BCKDK phosphorylates BCKDH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798374", "l": "DYRK2 phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12923", "l": "5-aminolevulinate + CO2 + CoA => glycine + H(+) + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34412", "l": "cannabigerolate + O2 => cannabidiolate + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71905", "l": "H(+) + N(2)-(ADP-D-ribosyl)-guanine + nicotinamide => guanine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19916", "l": "a (3R)-hydroxyacyl-[ACP] + NAD(+) <=> a 3-oxoacyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12492", "l": "L-methionine = D-methionine", "d": [], "t": []}, {"i": "EC:5.1.1.2", "l": "\"methionine racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12239", "l": "H2O + NADP(+) + nicotinate <=> 6-hydroxynicotinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10327", "l": "an L-glycol + NADP(+) <=> a 2-hydroxycarbonyl + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17090", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate => D-glyceraldehyde 3-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047999", "l": "hyponitrite reductase activity", "d": ["Catalysis of the reaction: 2 hydroxylamine + 2 NAD+ = 2 H+ + hyponitrous acid + 2 NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23285", "l": "isopentenyl diphosphate => dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74543", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (E,E,E)-alpha-springene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983696", "l": "The Immunoglobulin of the BCR binds antigen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981353", "l": "RASA1 stimulates RAS GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018756", "l": "RHOH binds GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018495", "l": "2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033276", "l": "NTRK2 binds TIAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382053", "l": "Translocation of PDGF from ER to Golgi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63347", "l": "ATP + L-amino acyl-L-threonyl-[protein] <=> (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016629", "l": "12-oxophytodienoate reductase activity", "d": ["Catalysis of the reaction: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-en-1-yl}cyclopentyl]octanoate + NADP+ = (15Z)-12-oxophyto-10,15-dienoate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69341", "l": "(E)-prop-1-en-1-SO-peroxol => (Z)-propanethial S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.388", "l": "\"glucose-6-phosphate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47740", "l": "1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate = CO2 + demethylphylloquinone + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.130", "l": "\"2-carboxy-1,4-naphthoquinone phytyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75872", "l": "Conversion of malonyl-CoA and acetyl-CoA to palmitate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011595", "l": "GSTZ1 dimer dehalogenates DCA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.15", "l": "\"mycothione reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64692", "l": "isobutanol + NAD(+) = 2-methylpropanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473584", "l": "Collagen type III degradation by MMP15 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18600", "l": "H(+) + NAD(+) + 2 reduced [rubredoxin] <=> NADH + 2 oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8960973", "l": "RLBP1:11cRAL dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2984226", "l": "PLK1 phosphorylates NEK9 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63371", "l": "ATP + H2O + spermine(out) <=> ADP + H(+) + phosphate + spermine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102605", "l": "cyclooctat-9-en-5,7-diol C18-monooxygenase activity", "d": ["Catalysis of the reaction: cyclooctat-9-en-5,7-diol + O2 + NADPH + H+ = cyclooctatin + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52483", "l": "16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68744", "l": "2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30408", "l": "hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] => oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58552", "l": "15alpha-stemmadenine intermediate II + H2O = (16R)-deshydroxymethyl-stemmadenine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029270", "l": "Recruitment of PLCgamma to membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61788", "l": "ATP + holo-[peptidyl-carrier protein] + L-tryptophan = AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein]", "d": [], "t": []}, {"i": "EC:6.2.1.73", "l": "\"L-tryptophan--[L-tryptophyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936563", "l": "ISGylation of DDX58 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70941", "l": "L-methionine(out) => L-methionine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004333", "l": "fumarate hydratase activity", "d": ["Catalysis of the reaction: (S)-malate = fumarate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76111", "l": "4-methylumbelliferone beta-D-glucuronate + H2O = 4-methylumbelliferone + D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52737", "l": "(Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate => (Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45857", "l": "3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782434", "l": "THG1L transfers GMP to 5' end of tRNA(His) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106151", "l": "CNBH domain intrinsic ligand binding", "d": ["Interacting selectivity and noncovalently with a cyclic nucleotide mimicking protein motif that is part of the same protein. The CNBHD is a domain on KCNH channels that creates a binding pocket on the KCNH channel that resembles the cyclic nucleotide- binding domain on other ion channels. It binds to a peptide motif that is part of the same protein rather than a cyclic nucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74756", "l": "kaempferide + S-adenosyl-L-methionine => 3,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948136", "l": "ULK1 Translocates to the mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374696", "l": "Phosphorylation of L1 by p90rsk (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11566", "l": "alpha-D-glucose 1-phosphate + D-gluconate => 4-O-beta-D-glucopyranosyl-D-gluconate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.286", "l": "\"isocitrate--homoisocitrate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57670", "l": "(+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9864415", "l": "AAC1 imports a proton (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26122", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11230", "l": "(2S)-flavanone + H(+) + NADPH => (2S)-flavan-4-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40811", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69417", "l": "H(+) + H2O2 + thiocyanate => H2O + hypothiocyanous acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32218", "l": "(6R)-NADHX <=> (6S)-NADHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39043", "l": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35356", "l": "3-hydroxyisopentadecanoyl-CoA => (2E)-13-methyltetradecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50134", "l": "ethanol + H(+) + hexadecanoate => ethyl hexadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23572", "l": "3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + phlorisovalerophenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9842641", "l": "Active LTK receptor binds SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77280", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA => 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73458", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + salvigenin <=> 8-hydroxysalvigenin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322427", "l": "Beta-catenin recruits CBP/p300 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11510", "l": "3-hydroxy-L-aspartyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37179", "l": "(9Z)-octadecenoyl-CoA + 1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate = (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.49", "l": "\"bothropasin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12320", "l": "17-O-acetylnorajmaline + NADP(+) = 1,2-dihydrovomilenine + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.73", "l": "\"1,2-dihydrovomilenine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66083", "l": "2-oxopentanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20275", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62040", "l": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate = N-octanoylsphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22422", "l": "2 H(+) + maleylacetate + NADH => cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11042", "l": "3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O => D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24317", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198371", "l": "AKT phosphorylates GSK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16856", "l": "N(6)-(1,2-dicarboxyethyl)-AMP <=> AMP + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112510", "l": "IL6ST is tyrosine phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75208", "l": "Ag(+)(out) => Ag(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070538", "l": "oleic acid binding", "d": ["Binding to oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9824888", "l": "OPTN, TBK1 bind ubiquitinated MOM proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74747", "l": "myricetin + S-adenosyl-L-methionine = 3-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371422", "l": "ATP hydrolysis by HSP70 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73299", "l": "(S)-malate(out) + H(+)(in) + phosphate(in) = (S)-malate(in) + H(+)(out) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0032397", "l": "activating MHC class I receptor activity", "d": ["Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661425", "l": "BIL:ALB dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11404", "l": "UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate", "d": [], "t": []}, {"i": "EC:5.1.3.6", "l": "\"UDP-glucuronate 4-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48849", "l": "(9Z,12Z)-octadecadienoate + O2 => 13-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21005", "l": "(R)-pantolactone + A => 2-dehydropantolactone + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39396", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37910", "l": "(9Z)-octadecenoate + O2 <=> (8E,10S)-10-hydroperoxy-octadeca-8-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64182", "l": "a fatty acid + L-tryptophan => an N-(fatty acyl)-L-tryptophan + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58922", "l": "(+)-medicarpin + H2O => (3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408500", "l": "GSSeH condenses with GSH to form H2Se and GSSG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23179", "l": "acetate + ATP + CoA <=> acetyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18075", "l": "AH2 + orotate => (S)-dihydroorotate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63435", "l": "1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0052706", "l": "histidine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75413", "l": "H(+) + lactenocin + S-adenosyl-L-homocysteine => demethyllactenocin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29987", "l": "adenosine(in) + H(+)(in) = adenosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50933", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70974", "l": "D-dopa + H2O + O2 <=> 3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57702", "l": "5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine => a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697018", "l": "Addition of sialic acids on some Spike glycosyl sidechains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15062", "l": "2 a Fe(II)-siderophore + H(+) + NAD(+) => 2 a Fe(III)-siderophore + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68570", "l": "(3S)-1,2-diazinane-3-carboxylate + H(+) + H2O => N(5)-hydroxy-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47482", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => deoxycholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5159250", "l": "ATF7IP binds SETDB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54461", "l": "1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354124", "l": "Phosphorylation of pPTK2 by SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62424", "l": "(E)-caffeoyl-CoA + H2O = 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28275", "l": "(S)-S-adenosyl-L-methionine => (R)-S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73414", "l": "succinate(in) + sulfate(out) <=> succinate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63463", "l": "(2E,6E,10E)-geranylgeraniol + GTP <=> (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047007", "l": "pregnan-21-ol dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + pregnan-21-ol = H+ + NADH + pregnan-21-al."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390641", "l": "ADRA1A,B,D bind ADR,NAd (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20638", "l": "D-fructose + D-glucose => D-glucono-1,5-lactone + D-sorbitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72129", "l": "agmatine(out) + H(+)(in) => agmatine(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30935", "l": "H2O + nicotinate beta-D-ribonucleotide = beta-D-ribosylnicotinate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070260", "l": "5'-tyrosyl-DNA phosphodiesterase activity", "d": ["Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0003878", "l": "ATP citrate synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + ADP + H+ + oxaloacetate + phosphate = ATP + citrate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.122", "l": "\"(S)-8-oxocitronellyl enol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50298", "l": "2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018820", "l": "cyanamide hydratase activity", "d": ["Catalysis of the reaction: urea = cyanamide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858475", "l": "ppDVL recruits RAC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43343", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24811", "l": "3-methyl-2-oxobutanoate + H2O => (2R)-2,3-dihydroxy-3-methylbutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78146", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> a 1,3-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47384", "l": "4-acetoxyphenol + H2O = acetate + H(+) + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39530", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH <=> (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028724", "l": "AMOT proteins bind YAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33369", "l": "D-glucose 6-phosphate(in) + L-histidyl-[protein] => D-glucose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75034", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate <=> 2-(9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35151", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) = (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27333", "l": "6-hydroxynicotinate + 2 H(+) + NADH + O2 = 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.114", "l": "\"6-hydroxynicotinate 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830864", "l": "Mature G localizes to host cell plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009936", "l": "RNASEL cleaves cellular ssRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679239", "l": "ULK complex translocates to the ER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28985", "l": "nitrite(out) => nitrite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15485", "l": "(2R,3S)-homoisocitrate = cis-homoaconitate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.36", "l": "\"homoaconitate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10051", "l": "methanethiol + O-acetyl-L-homoserine <=> acetate + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34469", "l": "diphosphate + valerena-4,7(11)-diene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-178208", "l": "SMAD7 binds to SMURF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65383", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047860", "l": "diiodophenylpyruvate reductase activity", "d": ["Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0034431", "l": "bis(5'-adenosyl)-hexaphosphatase activity", "d": ["Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate."], "t": []}, {"i": "RHEA:32047", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'-pentaphosphate + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21325", "l": "2 H(+) + reduced [rubredoxin] + superoxide => H2O2 + oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64642", "l": "lactose + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448702", "l": "Caspase-1 active tetramer formation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114684", "l": "Phosphorylation of Syntaxin-4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50233", "l": "8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54055", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + tau-cadinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159868", "l": "Furin cleaves pro-factor VII to factor VII (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51109", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990244", "l": "histone H2AT120 kinase activity", "d": ["Catalysis of the reaction: histone H2A-threonine (position 120) + ATP = histone H2A-phosphothreonine (position 120) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 120 of histone H2A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30111", "l": "Fe(III)-enterobactin + H(+) + 3 H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}, {"i": "EC:3.1.1.108", "l": "\"iron(III) enterobactin esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18013", "l": "H2O + N(5)-ethyl-L-glutamine = ethylamine + L-glutamate", "d": [], "t": []}, {"i": "EC:3.5.1.65", "l": "\"theanine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050001", "l": "D-glutaminase activity", "d": ["Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176517", "l": "SULTs transfer (SO4)2- group to PREG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56307", "l": "ATP + H2O + rifampicin <=> 21-phosphorifampicin + AMP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57476", "l": "dodecanoate + H2O2 = 2-hydroxydodecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034336", "l": "misfolded RNA binding", "d": ["Binding to an RNA molecule that has assumed an incorrect conformation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34873", "l": "methanol(in) => methanol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5689111", "l": "PARK2 autoubiquitinates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17032", "l": "(S)-allantoin + H2O <=> allantoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42503", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) <=> 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784160", "l": "IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019841", "l": "retinol binding", "d": ["Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717841", "l": "holo-FDPS dimer binds NBPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63572", "l": "H2O + neurotensin-(1-8) = L-arginine + neurotensin-(1-7)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55024", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39368", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH => (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36408", "l": "ATP + hydrogencarbonate + L-threonine => diphosphate + H2O + L-threonylcarbamoyladenylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50420", "l": "L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] = H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64216", "l": "2-carboxy-L-lyxonate + H(+) = CO2 + L-lyxonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055041", "l": "cyclopentanol dehydrogenase activity", "d": ["Catalysis of the reaction: cyclopentanol + NAD+ = cyclopentanone + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683769", "l": "O-glycosylation of 3a is terminated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177284", "l": "PKA phosphorylates PDE4B (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49846", "l": "(-)-dehydrodiconiferyl acid ketone + a quinol => (-)-dehydrodiconiferyl acid + a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668831", "l": "CST complex formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57930", "l": "ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate => ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52283", "l": "(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033433", "l": "AUU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AUU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11970", "l": "7,8-dihydro-7,8-dihydroxykynurenate + A => AH2 + kynurenate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604664", "l": "ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55522", "l": "3 diphosphate + nerylneryl diphosphate => dimethylallyl diphosphate + 3 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48543", "l": "1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O <=> dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654409", "l": "Activated FGFR3 binds FRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68317", "l": "1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O => 1D-myo-inositol 2,4,5-triphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76414", "l": "2',3'-cGAMP(out) + n H(+)(out) <=> 2',3'-cGAMP(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21129", "l": "S-adenosyl-L-methionine + zymosterol => fecosterol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11814", "l": "formaldehyde + H(+) + H2O2 + hydrogen sulfide => H2O + methanethiol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55400", "l": "7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) = archaeosine(15) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.302", "l": "\"2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793958", "l": "Expression of STAT6-upregulated plasma membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14086", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA => 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865276", "l": "PDGF-AB clevage by Furin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.307", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16525", "l": "2-dehydro-3-deoxy-D-galactonate + ATP = 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0019152", "l": "acetoin dehydrogenase activity", "d": ["Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54727", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41946", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP => [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72517", "l": "(R)-carnitine(in) + glutarate(out) => (R)-carnitine(out) + glutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509827", "l": "ITPA hydrolyses ITP to IMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008043", "l": "MAPK8 phosphorylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10503", "l": "butanoyl-CoA + glyoxylate + H2O <=> 3-ethylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77980", "l": "all-trans-hexaprenyl diphosphate + H2O => colleterpenol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16654", "l": "D-gluconate + NADP(+) => 2-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38148", "l": "carbon disulfide + H2O => carbonyl sulfide + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38916", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49104", "l": "Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine = 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686625", "l": "LAIR1 binds collagen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45198", "l": "5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+) => 5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18746", "l": "2 juglone + O2 => 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23882", "l": "N(pros)-phospho-L-histidyl-[protein] + pyruvate => L-histidyl-[protein] + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59241", "l": "L-arginine + L-lysine => L-homoarginine + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76649", "l": "(E)-2,3-didehydroadipoyl-CoA + H2O => (3S)-3-hydroxyadipyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59295", "l": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O <=> D-galactose + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198314", "l": "DAG stimulates protein kinase C-delta (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35133", "l": "H(+)(in) + L-alanyl-L-glutamate(in) => H(+)(out) + L-alanyl-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76827", "l": "butylamine + H2O + NAD(+) = butanal + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680348", "l": "PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034820", "l": "4,9-DSHA hydrolase activity", "d": ["Catalysis of the reaction: (3E,1Z)-4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70692", "l": "ornithine => putrescine + CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44597", "l": "a fatty acyl-[ACP] + H2O => a fatty acid + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9838081", "l": "LONP1 degrades mitochondrial matrix proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44891", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55653", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824587", "l": "MITF-M-dependent BCL2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375131", "l": "Basigin binds CD98 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14443", "l": "CoA + H(+) + N(3)-acetylgentamycin C => acetyl-CoA + gentamicin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51599", "l": "2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63841", "l": "[thioredoxin]-dithiol + tert-butyl hydroperoxide => [thioredoxin]-disulfide + H2O + tert-butanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39131", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69264", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate = an isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446364", "l": "Migfilin interacts with VASP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031845", "l": "type 5 neuropeptide Y receptor binding", "d": ["Binding to a type 5 neuropeptide Y receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189488", "l": "UROS transforms HMB to URO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59581", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester => CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74194", "l": "carbofuran + H(+) + H2O <=> 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-ol + CO2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44273", "l": "3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA => 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62286", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+) => 2 ATP + L-proline + L-tryptophan + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220957", "l": "NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59245", "l": "3''-O-acetyl-ADP-D-ribose + H2O => acetate + ADP-D-ribose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60606", "l": "1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29699", "l": "dimethyl sulfoxide(in) = dimethyl sulfoxide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45890", "l": "4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75172", "l": "Formation of RAD50:MRE11 complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78493", "l": "CMP-5'-(N-hydroxy-3-aminopropyl)phosphonate + H2O + NADP(+) => CMP-5'-(3-aminopropyl)phosphonate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46744", "l": "ATP + hydrogencarbonate = ADP + carboxyphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68798", "l": "alpha-D-glucose + D-glucose => D-maltose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21955", "l": "5alpha-pregnane-3,20-dione + NADP(+) <=> H(+) + NADPH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49059", "l": "asperlicin C + H(+) + NADPH + O2 <=> asperlicin E + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0030551", "l": "cyclic nucleotide binding", "d": ["Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72167", "l": "2 Na(+)(out) + taurohyodeoxycholate(out) = 2 Na(+)(in) + taurohyodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41725", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3777129", "l": "HDAC3 containing complexes deacetylate histone (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41671", "l": "dihydrochelirubine + NADP(+) <=> chelirubine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14681", "l": "2 2-aminophenol + A + O2 = 2-aminophenoxazin-3-one + AH2 + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68824", "l": "(2E)-geranyl diphosphate = (Z)-beta-ocimene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.40", "l": "\"hex-5-enoyl-[acyl-carrier protein] acetylenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102252", "l": "cellulose 1,4-beta-cellobiosidase activity (reducing end)", "d": ["Catalysis of the reaction: n H2O + a cellodextrin = n beta-cellobiose, releasing cellobiose from the reducing ends of the chains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031713", "l": "B2 bradykinin receptor binding", "d": ["Binding to a B2 bradykinin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49670", "l": "deoxyviolaceinate + H2O + NAD(+) => H(+) + NADH + O2 + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25245", "l": "(R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43976", "l": "H(+) + hexadecanoate + NADPH + O2 = 14-hydroxyhexadecanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20487", "l": "(S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10224", "l": "ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60608", "l": "1-tetradecanoyl-sn-glycero-3-phosphoethanolamine = 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036191", "l": "indolin-2-one monooxygenase activity", "d": ["Catalysis of the reaction: indolin-2-one + NAD(P)H + H+ + O2 = 3-hydroxyindolin-2-one + NAD(P)+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64672", "l": "2-(methylsulfanyl)acetyl-CoA + butan-1-ol = butyl 2-(methylsulfanyl)acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70436", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2 => a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156930", "l": "GTP-binding activates eEF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74894", "l": "CO2(out) <=> CO2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58942", "l": "all-trans-lycopaoctaene + diphosphate + NAD(+) => (1R,2R,3R)-prephytoene diphosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14066", "l": "scyllo-inosose => 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0005436", "l": "sodium:phosphate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237129", "l": "Acireductone is created (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54891", "l": "(1S,2S)-OPC-8 + ATP + CoA <=> AMP + diphosphate + OPC8-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69162", "l": "H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+) => agmatine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.178", "l": "\"beta-porphyranase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851352", "l": "CCR8 binds CCL1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5681980", "l": "ATG12 binds ATG7 dimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30678", "l": "tetrahymanol <=> H2O + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38297", "l": "2-oxoglutarate + AH2 => (R)-2-hydroxyglutarate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69262", "l": "(3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27510", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine = dehydro coenzyme F420-0 + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68579", "l": "ATP + H2O + xanthine(out) <=> ADP + H(+) + phosphate + xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13488", "l": "2-oxoglutarate + S-(4-bromophenyl)-L-cysteine <=> 3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35345", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH => 3-hydroxydocosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030756", "l": "isoorientin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H+ + isoscoparin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805981", "l": "HMGB1 release from cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10733", "l": "ATP + firefly D-luciferin + O2 => AMP + CO2 + diphosphate + firefly oxyluciferin + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222491", "l": "Lactoferrin scavenges iron ions (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38086", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72387", "l": "2 hydrogencarbonate(out) + sulfate(in) = 2 hydrogencarbonate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73910", "l": "4-hydroxy-N,N,N-trimethyltryptamine + ATP <=> ADP + aeruginascin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75336", "l": "bromide(in) + chloride(out) => bromide(out) + chloride(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047462", "l": "phenylalanine racemase (ATP-hydrolyzing) activity", "d": ["Catalysis of the reaction: L-phenylalanine + ATP + H2O = D-phenylalanine + AMP + diphosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34222", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218805", "l": "PKC autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854466", "l": "VLDLR binds RELN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65277", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013024", "l": "RHOB binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40508", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183052", "l": "CBL binds to GRB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65629", "l": "sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20185", "l": "a CMP-N-acyl-beta-neuraminate + H2O = an N-acylneuraminate + CMP + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.40", "l": "\"CMP-N-acylneuraminate phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665871", "l": "ADRM1 binds 26S proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57992", "l": "(20S)-ginsenoside C-K + UDP-alpha-D-glucose = (20S)-ginsenoside F2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32272", "l": "(2R,3S)-3-isopropylmalate + NAD(+) => 4-methyl-2-oxopentanoate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61909", "l": "2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol => 2 AMP + asperphenamate + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55110", "l": "(3R)-hydroxynonanoyl-[ACP] + NADP(+) => 3-oxononanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77081", "l": "Formation of the CE:GMP intermediate complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21370", "l": "5-hydroxyisourate + H2O2 => H2O + O2 + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59503", "l": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32237", "l": "AMP + H(+) + NADPH + phosphate => (6S)-NADPHX + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74401", "l": "2 (S)-lactate(out) + prostaglandin F2alpha(in) => 2 (S)-lactate(in) + prostaglandin F2alpha(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391168", "l": "SIRP gamma binds CD47 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43726", "l": "H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase] => (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21774", "l": "NH4(+) + uridine(6666) in apoB mRNA => cytidine(6666) in apoB mRNA + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.21", "l": "\"Cd(2+)-exporting ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12743", "l": "IDP + NH4(+) => ADP + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43835", "l": "5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56853", "l": "reumycin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + toxoflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63717", "l": "losartan + UDP-alpha-D-glucuronate => losartan-1-N-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012016", "l": "FAHD1 dimer hydrolyses OA to PYR (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29895", "l": "ATP + H2O + L-glutamine(out) = ADP + H(+) + L-glutamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19379", "l": "2 H(+) + NADPH + riboflavin => NADP(+) + reduced riboflavin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47441", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) => 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73453", "l": "adenosine 3',5'-bisphosphate(out) + AMP(in) => adenosine 3',5'-bisphosphate(in) + AMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78538", "l": "N-acetyl-alpha-neuraminate(out) + 2 Na(+)(out) <=> N-acetyl-alpha-neuraminate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9736953", "l": "FURIN translocates to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63188", "l": "3,4-dihydroxybenzaldehyde + AH2 + tyramine = A + H2O + norbelladine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46186", "l": "3-methylbutanoyl-CoA + AMP + diphosphate => 3-methylbutanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31997", "l": "7-epi-sesquithujene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62981", "l": "(9Z)-hexadecenamide + H2O => (9Z)-hexadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20497", "l": "a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66790", "l": "(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2 => N-methyl-L-dopa + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109862", "l": "MAP2K2 phosphorylates MAPK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693125", "l": "RHOF binds effectors at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50409", "l": "1-(2-aminophenyl)decane-1,3-dione => 2-heptyl-4(1H)-quinolone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797961", "l": "CHDH oxidises Cho to BETALD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20634", "l": "a (3R)-hydroxyacyl-[ACP] + L-ornithine => a lyso-ornithine lipid + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12322", "l": "1,2-dihydrovomilenine + 2 H(+) + NADPH => 17-O-acetylnorajmaline + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047981", "l": "histidine N-acetyltransferase activity", "d": ["Catalysis of the reaction: L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62426", "l": "3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA => (E)-caffeoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134800", "l": "STING dimerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483186", "l": "PC is converted to PS by PTDSS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.92", "l": "\"endopeptidase Clp\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2464822", "l": "RDH12 reduces atRAL to atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70692", "l": "ornithine => putrescine + CO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78486", "l": "2-amino-4-phosphonobutanoate + CTP <=> CMP-5'-(3-amino-3-carboxypropyl)phosphonate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40218", "l": "FADH2 + O2 <=> FAD + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78890", "l": "H2O + N-deacetylisoipecoside <=> D-glucose + N-deacetylisoipecoside aglycone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209792", "l": "N-acetylation of serotonin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0001163", "l": "RNA polymerase I transcription regulatory region sequence-specific DNA binding", "d": ["Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58797", "l": "a flavonol 7-O-beta-D-glucoside + malonyl-CoA => a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17798", "l": "[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose => [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78323", "l": "glyoxylate + L-glutamine = 2-oxoglutaramate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686343", "l": "IAV NS1 binds MLKL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832169", "l": "NS1 (1C) localizes to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73122", "l": "kaempferol + S-adenosyl-L-methionine <=> H(+) + kaempferol 7-methyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28966", "l": "H(+)(out) + L-proline(out) <=> H(+)(in) + L-proline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23489", "l": "1,4-benzoquinone + H(+) + NADPH => hydroquinone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694780", "l": "Spike translocates to ERGIC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48466", "l": "a ganglioside GA1 + N-acetylneuraminate => a ganglioside GM1b + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27728", "l": "2-hydroxy-3-oxopropanoate + pyruvate => 5-dehydro-4-deoxy-D-glucarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41645", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA => 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009017", "l": "succinylglutamate desuccinylase activity", "d": ["Catalysis of the reaction: N-succinyl-L-glutamate + H2O = L-glutamate + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32812", "l": "benzoate(in) => benzoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36571", "l": "sphinganine + tetradecanoyl-CoA = CoA + H(+) + N-(tetradecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708557", "l": "FBXL17 binds BACH1:MAFK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357472", "l": "PAK1-3 autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53624", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + tsukubadiene", "d": [], "t": []}, {"i": "EC:4.2.3.159", "l": "\"tsukubadiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043857", "l": "N-acetylornithine carbamoyltransferase activity", "d": ["Catalysis of the reaction: N(2)-acetyl-L-ornithine + carbamoyl phosphate = N(2)-acetyl-L-citrulline + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374298", "l": "Opioid receptors bind opioid peptides (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23308", "l": "(E)-sinapoyl-CoA + D-glucarate = 2-O-[(E)-sinapoyl]-D-glucarate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.131", "l": "\"glucarate O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17771", "l": "betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428690", "l": "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40167", "l": "hexadecanoyl-CoA + O2 = (2E)-hexadecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686430", "l": "MUS81 binds EME1, EME2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45905", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine => dTDP + epivancomycin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16973", "l": "2-hydroxypyridine + AH2 + O2 = 2,5-dihydroxypyridine + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.26", "l": "\"2-hydroxypyridine 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45267", "l": "(9Z,12Z)-octadecadienoate(out) <=> (9Z,12Z)-octadecadienoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227732", "l": "IPS1 interacts with TRADD, RIP1 and FADD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55827", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide d <=> a bacteriochlorophyllide f + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22117", "l": "luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate => H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57114", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77184", "l": "L-threonine + uridine-5'-aldehyde => (5'S,6'S)-C-glycyluridine + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69935", "l": "guanosine(out) + Na(+)(out) = guanosine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71054", "l": "L-leucine(out) + L-methionine(in) <=> L-leucine(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022856", "l": "protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69929", "l": "adenosine(in) + Na(+)(in) => adenosine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047147", "l": "trimethylsulfonium-tetrahydrofolate N-methyltransferase activity", "d": ["Catalysis of the reaction: (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004304", "l": "estrone sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050660", "l": "flavin adenine dinucleotide binding", "d": ["Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193964", "l": "CYP21A2 21-hydroxylates PROG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33914", "l": "an N-alkylglycine + H2O + O2 <=> an alkylamine + glyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56726", "l": "4-hydroxy-all-trans-beta-carotene + A + H2O => AH2 + all-trans-beta-carotene + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54590", "l": "H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine in 25S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112755", "l": "SOCS3 binds IL6ST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34002", "l": "zymosterol <=> 5alpha-cholesta-7,24-dien-3beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449818", "l": "IL13 binds IL13RA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53885", "l": "CDP-alpha-D-glucose + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682967", "l": "WHSC1 binds DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.57", "l": "\"caspase-4\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0046592", "l": "polyamine oxidase activity", "d": ["Catalysis of the oxidative degradation or interconversion of polyamines."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10324", "l": "an L-glycol + NADP(+) = a 2-hydroxycarbonyl + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21271", "l": "(R)-canadine + 2 NADP(+) <=> berberine + H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848023", "l": "Activated PTK6 binds STAP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28963", "l": "H(+)(out) + L-proline(out) = H(+)(in) + L-proline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55406", "l": "[phosphate](n+1) + UDP => [phosphate](n) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981606", "l": "Myoglobin binds oxygen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835011", "l": "PINK1 phosphorylates PRKN at S65 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701064", "l": "TRPV1 binds TRPV1 agonists (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15227", "l": "diphosphate + dTDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + dTTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10395", "l": "(E)-cinnamyl alcohol + NADP(+) <=> (E)-cinnamaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030341", "l": "chondroitin AC lyase activity", "d": ["Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168858", "l": "Palmitoylation of cysteine residues on HA in the cis-Golgi network (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783670", "l": "CRLF1 binds CLCF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51529", "l": "H(+) + vanillate => CO2 + guaiacol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32652", "l": "erythromycin D + S-adenosyl-L-methionine => erythromycin B + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13079", "l": "a carboxylate + D-hexose phosphate + H(+) => a D-hexose + an acyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0003861", "l": "3-isopropylmalate dehydratase activity", "d": ["Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74960", "l": "(3R)-3-isocyanylbutanoate + ATP + holo-[ACP] => (3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43600", "l": "3-oxoeicosanoyl-[ACP] + H(+) + NADPH = 3R-hydroxyeicosanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25360", "l": "(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] => biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102410", "l": "quercetin-4',3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin 4'-O-glucoside + UDP-alpha-D-glucose(2-) = quercetin 3,4'-O-diglucoside + UDP(3-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48154", "l": "ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GD1b(d18:1(4E)/18:0) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428750", "l": "Gq activation by TP receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627078", "l": "XIAP binds CASP9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5604929", "l": "Activated protein C binds Protein S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28887", "l": "H(+)(in) + L-serine(in) = H(+)(out) + L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205231", "l": "Dimerization of KIT upon SCF binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21819", "l": "a D-alpha-amino acid + H2O + O2 <=> a 2-oxocarboxylate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062204", "l": "(13S)-vitexifolin A synthase activity", "d": ["Catalysis of the reaction:9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate."], "t": []}, {"i": "RHEA:40027", "l": "9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690886", "l": "ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55839", "l": "calcitriol + UDP-alpha-D-glucuronate <=> calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0004556", "l": "alpha-amylase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769394", "l": "AKT phosphorylates CBY1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140912", "l": "membrane destabilizing activity", "d": ["Binding to a membrane and increasing its permeability. This may lead to cell membrane lysis and cell content release."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50493", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102906", "l": "7-epi-alpha-selinene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = (-)-7-epi-alpha-selinene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34521", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP => N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33191", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.n6", "l": "\"1-acylglycerophosphoserine O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71746", "l": "2-oxoglutarate(out) + hexanedioate(in) <=> 2-oxoglutarate(in) + hexanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74023", "l": "L-alanine(in) + L-serine(out) = L-alanine(out) + L-serine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19333", "l": "H(+) + oxalyl-CoA = CO2 + formyl-CoA", "d": [], "t": []}, {"i": "EC:4.1.1.8", "l": "\"oxalyl-CoA decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018641", "l": "6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity", "d": ["Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33138", "l": "malonate(in) + Na(+)(in) <=> malonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16142", "l": "2'-deoxymugineate + NAD(+) => 3''-deamino-3''-oxonicotianamine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972975", "l": "POU5F1 (OCT4), SOX2, NANOG Bind the SALL1 Promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34005", "l": "7-dehydrodesmosterol + 2 H2O + NADP(+) => 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44057", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018785", "l": "RHOBTB2 binds GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55996", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43782", "l": "(2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45010", "l": "octadecanoate + sphinganine => H2O + N-(octadecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3785768", "l": "MRN complex binds DNA double strand breaks (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69426", "l": "acetone + formyl-CoA => 2-hydroxyisobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13955", "l": "a D-alpha-amino acid + a tRNA + H(+) => a D-aminoacyl-tRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102122", "l": "gibberellin A34 carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: gibberellin A34 + S-adenosyl-L-methionine = gibberellin A34 methyl ester + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665748", "l": "FMNL2 binds RHOC:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60716", "l": "(1R,3R)-chrysanthemal + H2O + NADP(+) = (1R,3R)-chrysanthemate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19767", "l": "3-hydroxypropanal + H2O => glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34713", "l": "15-methylhexadecasphing-4-enine + a fatty acid => H2O + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36742", "l": "heptadecasphing-4-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.54", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010872", "l": "SLIT2 binds Dystroglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445088", "l": "CHL1 interacts with beta1 integrins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64219", "l": "2-carboxy-L-lyxonate + H(+) <=> CO2 + L-lyxonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787820", "l": "IL34 dimer binds CSF1R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20700", "l": "ATP + lipid A disaccharide (E. coli) = ADP + H(+) + lipid IVA (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45191", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662620", "l": "MT3 binds cadmium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390453", "l": "Hydrolysis of ATP and release of folded actin from CCT/TriC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010647", "l": "ROBO3.1 binds AKAP5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6802973", "l": "PLK3 phosphorylates CDC25C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839377", "l": "TGFB1,TGFB2 bind TGFBR3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824219", "l": "Expression of NOTCH1 in paraxial mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682598", "l": "ATM phosphorylates HERC2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44513", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10724", "l": "GDP-6-deoxy-alpha-D-talose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046811", "l": "histone deacetylase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382056", "l": "Crk binds to the active PDGF receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43841", "l": "26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78676", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + silphinene => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + silphinene-15-oate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66661", "l": "ATP + beta-D-glucosylceramide(in) + H2O => ADP + beta-D-glucosylceramide(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49571", "l": "2-glutathionyl-2-methylbut-3-en-1-ol <=> (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9608048", "l": "Expression of PLIN1 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53394", "l": "(2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45128", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22460", "l": "a 2,3-saturated acyl-CoA + NADP(+) = a 2,3-dehydroacyl-CoA + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.8", "l": "\"acyl-CoA dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13019", "l": "5-phospho-alpha-D-ribose 1-diphosphate + uracil => diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395320", "l": "Latent TGF-beta-1 binds integrins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46524", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.12", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49237", "l": "N(pros)-phospho-L-histidyl-[protein](out) + sucrose => L-histidyl-[protein] + sucrose 6(G)-phosphate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844438", "l": "NLRP1 oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874080", "l": "SRC phosphorylates PTK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62613", "l": "adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19818", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15157", "l": "4-hydroxyphenylacetate + H(+) + NADPH + O2 = H2O + homogentisate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6804100", "l": "HMGB1 binds LPS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15372", "l": "2,3-dihydroxybenzoate + O2 <=> 2-carboxy-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62750", "l": "(S)-2-methylbutanoate + H(+) + monacolin J => H2O + lovastatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103046", "l": "alanylglutamate dipeptidase activity", "d": ["Catalysis of the reaction: L-alanyl-L-glutamate + H2O = L-alanine + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41524", "l": "5 H(+) + 5 malonyl-CoA = 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol", "d": [], "t": []}, {"i": "EC:2.3.1.233", "l": "\"1,3,6,8-tetrahydroxynaphthalene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-532549", "l": "MPI isomerises Fru6P to Man6P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448480", "l": "IL22 binds IL22RA1:JAK1 receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77027", "l": "D-serine + H2O + NAD(+) = 3-hydroxypyruvate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31720", "l": "11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46582", "l": "25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16483", "l": "3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine => 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450533", "l": "PKCdelta phosphorylates HuR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77142", "l": "1D-myo-inositol 2,3-bisphosphate + H2O <=> 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34365", "l": "diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35068", "l": "(S)-carnitine(out) => (S)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54619", "l": "2-oxoglutarate + heptadecanoyl-CoA + O2 <=> 2-hydroxyheptadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866277", "l": "AP-2 directly binds some endocytic cargo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59494", "l": "(2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate => (2E)-geranyl diphosphate + L-tryptophyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034879", "l": "2,3,6-trihydroxyisonicotinate decarboxylase activity", "d": ["Catalysis of the reaction: 2,3,6-trihydroxyisonicotinate = 2,3,6-trihydroxypyridine + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426151", "l": "SREBP1A,2 binds the SQLE promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51306", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68203", "l": "1,2-dihexanoylglycerol + hexadecanoyl-CoA <=> 1,2-dihexanoyl-3-hexadecanoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21041", "l": "CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031856", "l": "Sulfido conjugates translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17816", "l": "D-altronate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21584", "l": "NAD(+) + propane-1,2-diol 1-phosphate = H(+) + hydroxyacetone phosphate + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.7", "l": "\"propanediol-phosphate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60664", "l": "H2O + NADPH = NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67803", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78090", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57984", "l": "(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose = (20S)-ginsenoside Rd + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432162", "l": "Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16677", "l": "fluoroacetaldehyde + H2O + NAD(+) = fluoroacetate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.69", "l": "\"fluoroacetaldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37575", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050614", "l": "delta24-sterol reductase activity", "d": ["Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705926", "l": "AR binds AR agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78429", "l": "D-xylose(in) => D-xylose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28872", "l": "D-fructuronate(in) + H(+)(in) => D-fructuronate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21697", "l": "N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657786", "l": "NR1H2,3 binds the APOD gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27992", "l": "1-deoxy-D-xylulose 5-phosphate + ADP + H(+) => 1-deoxy-D-xylulose + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63068", "l": "acetyl-CoA + 2 H(+) + 2 malonyl-CoA = 2 CO2 + 3 CoA + triacetate lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975170", "l": "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0071949", "l": "FAD binding", "d": ["Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28081", "l": "2-hydroxyethylphosphonate + NAD(+) <=> H(+) + NADH + phosphonoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.472488299857119", "identifiers": [{"i": "GO:0030533", "l": "triplet codon-amino acid adaptor activity", "d": ["The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847880", "l": "CYTH proteins bind ARF1:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16090", "l": "H2O + phosphoethanolamine => ethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035446", "l": "cysteine-glucosaminylinositol ligase activity", "d": ["Catalysis of the reaction: 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + L-cysteine + ATP = 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + 2 H+. 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol is also known as glucosaminyl-inositol or GlcN-Ins, and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as desacetylmycothiol or Cys-GlcN-Ins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44367", "l": "2-epi-5-epi-valiolone + ATP <=> 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63195", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 <=> glycine betaine + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51433", "l": "(S)-1-aminoethylphosphonate + acetyl-CoA => [(1S)-1-acetamidoethyl]phosphonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41612", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = D-ribose 2,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10210", "l": "H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg) => an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75873", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429860", "l": "DCP1-DCP2 complex decaps mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010951", "l": "ROBO1 binds NRP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800836", "l": "TP53 or TP63 binds the PERP gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322431", "l": "XIAP binds TLE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14284", "l": "2 Fe(III)-[cytochrome c] + H2O + sulfite <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56334", "l": "AMP + ATP + H(+) => 5'-triphosphoadenylyl-(2'->5')-adenosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878056", "l": "RUNX1:CBFB binds EP300 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21715", "l": "L-threo-3-phenylserine <=> benzaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50368", "l": "2-methylbutan-2-ol + H(+) + NADPH + O2 = 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.19.48", "l": "\"tert-amyl alcohol desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437995", "l": "Activated JNK migrates to the nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141409", "l": "Mad1 binds kinetochore (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007707", "l": "DLX5,(DLX6) binds RUNX2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66898", "l": "4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase] => 4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54100", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14566", "l": "(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48255", "l": "a ganglioside GD2 + UDP-alpha-D-galactose <=> a ganglioside GD1b + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607736", "l": "MALT1 oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20678", "l": "alizarin + UDP-alpha-D-glucose => 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19297", "l": "ATP + beta-alanine + L-histidine = ADP + carnosine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77690", "l": "a ganglioside GD1a (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a ganglioside GalNAc-GD1a (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20449", "l": "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.36", "l": "\"chloridazon-catechol dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36502", "l": "2-dehydro-3-deoxy-L-rhamnonate + NAD(+) <=> 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12199", "l": "keto-D-fructose 6-phosphate + phosphate <=> acetyl phosphate + D-erythrose 4-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59579", "l": "anserine + H2O <=> beta-alanine + N(pros)-methyl-L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9866272", "l": "2Fe-2S is inserted in UQCRFS1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621370", "l": "SYK autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944214", "l": "Association of procollagen type I (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77139", "l": "1D-myo-inositol 2,3-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610442", "l": "Tail-anchored protein:SGTA dimer binds BAG6:GET4:UBL4A and ASNA1:ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638006", "l": "ARL3 hydrolyzes GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034335", "l": "DNA negative supercoiling activity", "d": ["Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9853512", "l": "DLST transfers succinyl to CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21911", "l": "NADP(+) + scytalone <=> H(+) + NADPH + naphthalene-1,3,6,8-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56708", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.171", "l": "\"beta-amyrin 16alpha-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167419", "l": "The receptor:G-protein complex releases GDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617815", "l": "BBSome binds RAB3IP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59060", "l": "(20S)-ginsenoside Rg3 + H2O = (20S)-ginsenoside Rh2 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69223", "l": "a (Z)-glucosinolate + H2O <=> a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61838", "l": "ergosteryl 3-beta-D-glucoside + H(+) + UDP => ergosterol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79132", "l": "cholate + L-alanine => H2O + L-alanocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66457", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35977", "l": "A + CO2 + H2O + succinate + verruculogen => 2-oxoglutarate + AH2 + fumitremorgin B + 2 O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79011", "l": "ent-copalyl diphosphate = diphosphate + ent-beyerene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28912", "l": "H(+)(out) + L-lysine(out) => H(+)(in) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141691", "l": "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15322", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106431", "l": "N6-methyl-(d)ATP hydrolase activity", "d": ["Catalysis of the reaction N6-methyl-(d)ATP + H2O = N6-methyl-(d)AMP + diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78176", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol => a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20453", "l": "scopoletin + UDP-alpha-D-glucose = H(+) + scopolin + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.128", "l": "\"scopoletin glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15321", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.93", "l": "\"3,9-dihydroxypterocarpan 6a-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071567", "l": "deUFMylase activity", "d": ["A thiol-dependent isopeptidase activity that cleaves UFM1 from a target protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39805", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008115", "l": "sarcosine oxidase activity", "d": ["Catalysis of the reaction: H2O + O2 + sarcosine = formaldehyde + glycine + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16388", "l": "4-hydroxybenzoate + 2 H(+) + NADPH + O2 <=> CO2 + H2O + hydroquinone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850961", "l": "PREX2 binds PTEN and inhibits it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31806", "l": "H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose <=> 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61111", "l": "(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72709", "l": "GDP-beta-L-fucose(out) + GMP(in) => GDP-beta-L-fucose(in) + GMP(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.55", "l": "\"venombin AB\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69830", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70340", "l": "alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O => beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781953", "l": "YOD1 binds VCP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110307", "l": "REV1 binds AP-dsDNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18909", "l": "2,4,6-trichlorophenol + S-adenosyl-L-methionine = 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.136", "l": "\"chlorophenol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218906", "l": "RIPK3 phosphorylates MLKL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58910", "l": "C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+) => 7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35337", "l": "3-oxoisoheptadecanoyl-CoA + CO2 + CoA => H(+) + isopentadecanoyl-CoA + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20772", "l": "2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin", "d": [], "t": []}, {"i": "EC:2.5.1.9", "l": "\"riboflavin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78017", "l": "a 2-acylglycerol + a fatty acid + H(+) => a 1,2-diacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428123", "l": "KDSR reduces 3-ketosphingoid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58984", "l": "acrolein + H2O + O2 = acrylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176175", "l": "Stalling of DNA replication fork and RPA binding (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114354", "l": "SMAC binds XIAP:Caspase-7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61329", "l": "O2 + parthenolide + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20574", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.14", "l": "\"oleoyl-[acyl-carrier-protein] hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60407", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13408", "l": "4-coumaroyl-CoA + agmatine <=> CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10585", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9838289", "l": "CLPXP degrades mitochondrial matrix proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1471322", "l": "Beta-defensins are secreted (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419334", "l": "Melatonin receptors can bind melatonin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66364", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O = 6-methyl-3,7-dioxodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38497", "l": "a 1,3-diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174963", "l": "NAT1 acetylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944261", "l": "Association of procollagen type XIII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809663", "l": "Formation of hair keratin fibres (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52901", "l": "3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide => 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50949", "l": "a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O => a 2'-deoxyuridine in single-stranded DNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25910", "l": "an aldose + H2O2 => an alditol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9714580", "l": "SLC6A3 binds DRIs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72871", "l": "anthocyanin A3 + malonyl-CoA = anthocyanin A5 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2214351", "l": "PLK1 phosphorylates GORASP1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78150", "l": "a 1,3-diacylglycerol + H2O <=> a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77235", "l": "L-threonyl-[peptidyl-carrier protein] + salicyl-[ACP] = H(+) + H2O + holo-[ACP] + salicylmethyloxazolinyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73125", "l": "H(+) + rhamnacene + S-adenosyl-L-homocysteine => isorhamnetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052740", "l": "1-acyl-2-lysophosphatidylserine acylhydrolase activity", "d": ["Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16695", "l": "(Z)-2-methyl-5-isopropylhexa-2,5-dienal => alpha-pinene oxide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.69", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198813", "l": "GSTO dimers reduce DeHA to AscH- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15600", "l": "a Fe(III)-siderophore(out) + ATP + H2O <=> a Fe(III)-siderophore(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42740", "l": "guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.173", "l": "\"23S rRNA (guanine(2445)-N(2))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39849", "l": "a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+) => a 2-acylglycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036136", "l": "kynurenine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10526", "l": "CO2 + succinate semialdehyde => 2-oxoglutarate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692408", "l": "NPR2 binds NPPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051736", "l": "ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA."], "t": []}, {"i": "RHEA:54580", "l": "a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'-phospho-ribonucleoside-RNA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030743", "l": "23S rRNA (adenosine(1067)-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(1067) in 23S rRNA + H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51611", "l": "(R)-2-hydroxyglutarate + pyruvate <=> (R)-lactate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36272", "l": "caffeine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022396", "l": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-43) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13386", "l": "3-oxododecanoate + H(+) => 2-undecanone + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000327", "l": "PLK1 phosphorylates BORA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733216", "l": "COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67353", "l": "malonyl-CoA + rhaponticin => 6-O-malonyl-rhaponticin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34138", "l": "cannabigerolate + O2 <=> Delta(9)-tetrahydrocannabinolate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168886", "l": "Hemopexin binds Hemes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37626", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27360", "l": "iodide + S-adenosyl-L-methionine <=> iodomethane + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5221061", "l": "TDG excises 5-carboxylcytosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58829", "l": "(9S,10R)-epoxy-octadecanoate + H2O => 9R,10R-dihydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429860", "l": "DCP1-DCP2 complex decaps mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39401", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211219", "l": "Translocation of caspase-3 to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862733", "l": "CCR2, CCR3 bind CCL13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050365", "l": "tryptophanamidase activity", "d": ["Catalysis of the reaction: L-tryptophanamide + H2O = L-tryptophan + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51262", "l": "(10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351849", "l": "Caspase-mediated cleavage of Etk (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65880", "l": "1-hydroxy-5alpha-androstan-3,17-dione + A = 5alpha-androstan-1,3,17-trione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.69", "l": "\"SARS coronavirus main proteinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13950", "l": "H(+) + NADP(+) + 2 reduced [rubredoxin] => NADPH + 2 oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43287", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374899", "l": "Release of noradrenaline  at the synapse (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950342", "l": "EBI3:CANX binds IL27 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177934", "l": "EGFR autophosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71181", "l": "FAH cleaves 4FAA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102098", "l": "D-galacturonate reductase activity", "d": ["Catalysis of the reaction: L-galactonate + NADP = aldehydo-D-galacturonate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35225", "l": "2-oxo-dAMP + H(+) + phosphate => 2-oxo-dADP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9865663", "l": "MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20056", "l": "NAD(+) + ribitol <=> D-ribulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60260", "l": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.354", "l": "\"[histone H3]-lysine(4) N-trimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69140", "l": "RPA binds to the Flap (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68955", "l": "isoscopoletin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + scoparone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13841", "l": "Fe(II)2-[transferrin] + H(+) + NAD(+) = Fe(III)2-[transferrin] + NADH", "d": [], "t": []}, {"i": "EC:1.16.1.2", "l": "\"diferric-transferrin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34579", "l": "2 2-oxoglutarate + 2 O2 + pentalenolactone D = 2 CO2 + H2O + pentalenolactone F + 2 succinate", "d": [], "t": []}, {"i": "EC:1.14.11.36", "l": "\"pentalenolactone F synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918224", "l": "DDX58 is K63 polyubiquitinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371422", "l": "ATP hydrolysis by HSP70 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5387389", "l": "Hh processing variants are translocated to the cytosol in a VCP-dependent manner (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113402", "l": "Formation of DSIF:NELF:early elongation complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50067", "l": "ATP + H2O + taurochenodeoxycholate(in) <=> ADP + H(+) + phosphate + taurochenodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052823", "l": "2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity", "d": ["Catalysis of the reaction: (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.68", "l": "\"tentoxilysin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76510", "l": "(-)-2'-epi-GR24 + H2O <=> (-)-2'-epi-GR24 ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836275", "l": "TFAP2A binds TFAP2B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5444516", "l": "Formation of MSH2:MSH6 Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21049", "l": "ATP + isopropylamine + L-glutamate => ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938356", "l": "RMB14 binds RUNX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72753", "l": "L-phenylalanine + ochratoxin alpha => H2O + ochratoxin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102421", "l": "curcumin-4'-O-beta-D-gentiobioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: curcumin 4'-O-beta-D-gentiobioside + UDP-alpha-D-glucose = curcumin 4'-O-beta-D-gentiotrioside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36394", "l": "cholesterol + NADP(+) <=> desmosterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10446", "l": "(S)-laudanine + H(+) + S-adenosyl-L-homocysteine => (S)-reticuline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042242", "l": "cobyrinic acid a,c-diamide synthase activity", "d": ["Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22491", "l": "S-(hydroxymethyl)glutathione <=> formaldehyde + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013158", "l": "CDC42 GDIs block activation of CDC42 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69053", "l": "RFC binding displaces Pol Alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549322", "l": "OCT1 transports organic cations out of hepatic cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357828", "l": "RIPK1 is cleaved by CASP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538824", "l": "PP1 binds to phosphorylated TIM in complex with PER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45939", "l": "3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9692867", "l": "HRH3 binds pitosilant (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60030", "l": "4-terpineol + diphosphate => (2E)-geranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77448", "l": "4-methoxybenzaldehyde + hydrogen cyanide => (2S)-2-hydroxy-2-(4-methoxyphenyl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420724", "l": "CASR binds Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65647", "l": "(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799815", "l": "TP53 family members bind the FAS gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15350", "l": "L-glutamate + N(2)-acetyl-L-ornithine => L-ornithine + N-acetyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71815", "l": "3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L-thyronine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754974", "l": "ADK phosphorylates RBV (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140985", "l": "G protein-coupled chemorepellent receptor activity", "d": ["Combining with a chemorepellent and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33484", "l": "an acyl-CoA + ergosterol => CoA + ergosteryl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909724", "l": "Recruitment of IFNAR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57786", "l": "4-nitrocatechol + H(+) + NAD(+) + nitrite => 1,4-dinitrobenzene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52021", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 => A + H2O + resolvin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694442", "l": "CNIH2,3 bind GRIA1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56832", "l": "2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) = 2,3,6-trichlorohydroquinone + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002951", "l": "leukotriene-C(4) hydrolase", "d": ["Catalysis of the reaction leukotriene C(4) + H2O= leukotriene D(4) + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9652264", "l": "ERBB2 binds TKIs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605624", "l": "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660665", "l": "Caspase-8 binds MALT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64335", "l": "ATP + CoA + nicotinate <=> AMP + diphosphate + nicotinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64074", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O => acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443418", "l": "GP1b signaling involves c-Src (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49263", "l": "D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-galactose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63397", "l": "A + Fe(II)-heme i + H2O => AH2 + Fe(II)-hydroxyheme i", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27713", "l": "ATP + guanosine <=> ADP + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38858", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46039", "l": "2'-deoxycytidine + UTP <=> dCMP + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35101", "l": "fusidate(out) + H(+)(in) => fusidate(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956652", "l": "ITCH gene expression is stimulated by RUNX1 and YAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008736", "l": "L-fucose isomerase activity", "d": ["Catalysis of the reaction: L-fucose = L-fuculose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67705", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76741", "l": "5-dodecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecane + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40781", "l": "L-2-aminopentanoate + NH4(+) => 2-aminopentanenitrile + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71868", "l": "glycodeoxycholate(out) => glycodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952996", "l": "E2F7 forms homodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103000", "l": "UDP-glucose:4-hydroxylamino-2,6-dinitrotoluene-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 4-hydroxylamino-2,6-dinitrotoluene = 4-hydroxylamino-2,6-dinitrotoluene-O-glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62765", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001532", "l": "interleukin-21 receptor activity", "d": ["Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55671", "l": "11-cis-retinol--[retinol-binding protein] + NAD(+) <=> 11-cis-retinal--[retinol-binding protein] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822335", "l": "CCR4-NOT(CNOT6L) deadenylates mRNA in CCR4-NOT(CNOT6L):ZFP36L2:mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010348", "l": "lithium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168337", "l": "Docking and transport of the RNP:Karyopherin complex through the nuclear pore (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53623", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (-)-spiroviolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14019", "l": "ADP + beta-nicotinamide D-ribonucleotide + H(+) => ATP + beta-nicotinamide D-riboside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098613", "l": "methaneselenol methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + methaneselenol => S-adenosyl-L-homocysteine + dimethyl selenide."], "t": []}, {"i": "REACT:R-HSA-2408541", "l": "MeSeH is methylated to Me2Se by MeSeH methyltransferase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16567", "l": "3-(imidazol-5-yl)pyruvate + L-glutamate => 2-oxoglutarate + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951727", "l": "cAMP binds PKA tetramer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32144", "l": "L-arginine(in) => L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3266557", "l": "Factor I cleaves iC3b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61687", "l": "glycero-2-phosphocholine + H2O <=> glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3927959", "l": "SUMOylation of CREBBP with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38227", "l": "(9Z)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.923250621671642", "identifiers": [{"i": "GO:0022829", "l": "wide pore channel activity", "d": ["Enables the energy-independent facilitated diffusion of propanediol through a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71463", "l": "H2O + substance P = Gly-L-Leu-L-Met-NH2 + substance P(1-8)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218642", "l": "PTK2 autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49269", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 23S,25-dihydroxy-24-oxocholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78608", "l": "(3R)-hydroxyoctadecanoyl-CoA + NAD(+) => 3-oxooctadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.41", "l": "\"alditol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43074", "l": "erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818574", "l": "TASP1 cleaves KMT2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165033", "l": "Multimerization of Rev (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53162", "l": "an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate => H2O + N-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102279", "l": "lecithin:11-cis retinol acyltransferase activity", "d": ["Catalysis of the reaction: an 11-cis retinol-[cellular-retinol-binding-protein] + a phosphatidylcholine = a cellular-retinol-binding protein + an 11-cis-retinyl ester + a 1-lysophosphatidylcholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051538", "l": "3 iron, 4 sulfur cluster binding", "d": ["Binding to a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40224", "l": "4,8-dimethylnonanoyl-CoA + H2O => 4,8-dimethylnonanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73680", "l": "3'-AMP(in) + ADP(out) + H(+)(out) => 3'-AMP(out) + ADP(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63203", "l": "(10bS,4aR)-noroxomaritidine + H(+) + NADPH <=> (10bS,4aR)-oxomaritidine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78495", "l": "acetyl-CoA + CMP-5'-(N-hydroxy-3-aminopropyl)phosphonate = CMP-5'-(N-acetyl-N-hydroxy-3-aminopropyl)phosphonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31889", "l": "tirucalladienol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166387", "l": "The FA anion diffuses away laterally from UCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62842", "l": "GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9824882", "l": "IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863973", "l": "Fusion of ERC and phagosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15030", "l": "D-mannitol + NAD(+) => D-mannose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42476", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + O2 = 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26247", "l": "diphosphate + fusicocca-2,10(14)-diene => geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031800", "l": "type 3 metabotropic glutamate receptor binding", "d": ["Binding to a type 3 metabotropic glutamate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38085", "l": "1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69397", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28156", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+) => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73046", "l": "creatine(in) <=> creatine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420202", "l": "Secretin receptor binds secretin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26246", "l": "geranylgeranyl diphosphate => diphosphate + fusicocca-2,10(14)-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79083", "l": "(3R)-3-methyl-D-ornithyl-N(6)-L-lysine + NAD(+) = 2 H(+) + L-pyrrolysine + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43061", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => beta-D-glucose 1-phosphate + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388831", "l": "Phosphorylation of CD28 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36339", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60321", "l": "N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801637", "l": "TP53 stimulates PLK2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701147", "l": "TRPV1 binds TRPV1 blockers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54617", "l": "2-oxoglutarate + heptadecanoyl-CoA + O2 => 2-hydroxyheptadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31108", "l": "3-phenylpyruvate + O2 => (2-hydroxyphenyl)acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22625", "l": "(S)-4-hydroxy-2-oxopentanoate => acetaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42411", "l": "(2R)-2-phosphoglycerate + ATP <=> (2R)-2,3-bisphosphoglycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682388", "l": "Autophagosome maturation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9676264", "l": "Formation of the SET1B complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034018", "l": "ascopyrone tautomerase activity", "d": ["Catalysis of the reaction: 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74045", "l": "L-alanine(out) + L-methionine(in) => L-alanine(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0031267", "l": "small GTPase binding", "d": ["Binding to a small monomeric GTPase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74903", "l": "(2E)-2-butenoate + ATP + H(+) = (2E)-but-2-enoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22882", "l": "L-glutamate + prephenate => 2-oxoglutarate + L-arogenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20844", "l": "ATP + hydrogencarbonate + pyruvate = ADP + H(+) + oxaloacetate + phosphate", "d": [], "t": []}, {"i": "EC:6.4.1.1", "l": "\"pyruvate carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65564", "l": "(9Z)-octadecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610735", "l": "NUMB binds ITCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197963", "l": "DHFR2 reduces FOLA to DHF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008787", "l": "D-allose kinase activity", "d": ["Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.41", "l": "\"3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222325", "l": "Carboxymycobactin and mycobactin exchange their iron load (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61752", "l": "steviolbioside + UDP-alpha-D-glucose = H(+) + rebaudioside B + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20032", "l": "10-deoxysarpagine + NADP(+) <=> H(+) + NADPH + vellosimine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78270", "l": "H2O + omega-dicarboxyl-CoA <=> a dicarboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018758", "l": "RHOH binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57045", "l": "D-apionate + NAD(+) => 3-oxoisoapionate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41942", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate => [amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.54", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450550", "l": "PKCalpha phosphorylates HuR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28431", "l": "D-allose 6-phosphate => D-allulose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849094", "l": "ARHGAP35 binds RASA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67553", "l": "3'-phosphoadenylyl sulfate + cholate => adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.5", "l": "\"ribonuclease D\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31376", "l": "H(+) + pyrrole-2-carboxylate => 1H-pyrrole + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34916", "l": "D-galactose(in) => D-galactose(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139905", "l": "Translocation of activated BAD protein to mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420243", "l": "GHRH receptor binds GHRH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918230", "l": "Recruitment of TRAF6/TRAF2 to IPS-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928639", "l": "p-EFNB binds GRB4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44714", "l": "a 1-acylglycerol + a fatty acid + H(+) => a 1,2-diacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52937", "l": "3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O => (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47492", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH = isodeoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22449", "l": "ATP + pseudouridine => ADP + H(+) + psi-UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39673", "l": "(9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O => (9Z)-hexadecenoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112690", "l": "PTPN11 binds CBL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39205", "l": "NADP(+) + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60982", "l": "12-oxododecanoate + H(+) + NADH => 12-hydroxydodecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29527", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.258", "l": "\"dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427570", "l": "Group 3 - Selective Cl- transport (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.96", "l": "\"lactocepin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39009", "l": "a cholesterol ester(out) => a cholesterol ester(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27710", "l": "ATP + guanosine = ADP + GMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.6", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047698", "l": "beta-alanyl-CoA ammonia-lyase activity", "d": ["Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30937", "l": "beta-D-ribosylnicotinate + phosphate => H2O + nicotinate beta-D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54646", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O => trans-4-hydroxy-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805109", "l": "CDK2 phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77421", "l": "(2S,3E)-2-hydroxyhept-3-enenitrile => (E)-hex-2-enal + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928620", "l": "PAK1 autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449077", "l": "Interleukin-16 is secreted (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45808", "l": "galactarate = (2S,3R)-dihydroxy-5-oxohexanedioate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.158", "l": "\"galactarate dehydratase (D-threo-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65429", "l": "deamido-NAD(+)(in) + NAD(+)(out) => deamido-NAD(+)(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140811", "l": "histone H2AR3 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone 2A L-arginyl (position 3)= histone 2A L-citrullyl (position 3) + NH4+, resulting in histone H2A citrullination at position 3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26028", "l": "H2O + N(1)-acetylspermidine + O2 => 3-aminopropanal + H2O2 + N-acetylputrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726875", "l": "HCNs:cAMP bind SNIs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008684", "l": "TBK1 phosphorylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754129", "l": "CDK6 inhibitors bind CDK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79084", "l": "(3R)-3-methyl-D-ornithyl-N(6)-L-lysine + NAD(+) => 2 H(+) + L-pyrrolysine + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55408", "l": "[phosphate](n) + CTP = [phosphate](n+1) + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34568", "l": "CDP-alpha-D-paratose + NADP(+) => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250892", "l": "botF LC cleaves target cell VAMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36000", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050781", "l": "ortho-trichlorophenol reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2,4,6-trichlorophenol + 2 H+ + 2 e- = 2,4-dichlorophenol + HCl."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2396029", "l": "Latent TGF-beta-3 binds integrins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78543", "l": "2 L-cysteine = L-alanine + S-sulfanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5333678", "l": "CPNEs bind PL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15735", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2 => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76358", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(out) <=> n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28965", "l": "H(+)(in) + L-proline(in) => H(+)(out) + L-proline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51460", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamate = (9Z)-octadecenoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62636", "l": "a hydroperoxide + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein] = an alcohol + H2O + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}, {"i": "EC:1.11.1.28", "l": "\"lipoyl-dependent peroxiredoxin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804652", "l": "UACA binds apoptosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49818", "l": "3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide => 3 Fe(III)-[cytochrome c] + H2O + hydrazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668714", "l": "RAC1:GTP binds NOX1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226999", "l": "ADD1:ADD3 binds DMTN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10652", "l": "a long-chain fatty aldehyde + H2O + NAD(+) = a long-chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.48", "l": "\"long-chain-aldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2514831", "l": "Fibrillin-1 degradation by MMP14 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201443", "l": "Type II receptor phosphorylates type I receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874078", "l": "PTK2 autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202489", "l": "Oligomerization of Bcl10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30821", "l": "allantoate + H(+) => allantoin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36778", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> alpha-L-Fuc-(1->2)-[alpha-D-Gal-(1->3)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981093", "l": "IL12 bound to IL12R internalises (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69611", "l": "H2O + kojibiose = beta-D-glucose + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.216", "l": "\"kojibiose hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55616", "l": "a carotenoid psi-end group = a carotenoid epsilon-end group", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46427", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21542", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate => N-(5-phospho-beta-D-ribosyl)anthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41066", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14406", "l": "D-glucose + NADP(+) => D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30283", "l": "(-)-trans-permethrin + H2O = (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.88", "l": "\"pyrethroid hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202731", "l": "JAM3 dimerises (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14397", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) = (4Z)-2-oxohept-4-enedioate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.68", "l": "\"5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64279", "l": "chrysophanol-9-anthrone + O2 <=> chrysophanol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63554", "l": "angiotensin-(1-5) + L-histidyl-L-proline => angiotensin-(1-7) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12144", "l": "cyanidin 3-O-rutinoside + UDP-alpha-D-glucose = cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47986", "l": "diphosphate + hydroxysqualene => H2O + presqualene diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655835", "l": "Expression of ELOVL6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70274", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74726", "l": "Dissociation of insulin from insulin receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18699", "l": "(4-hydroxyphenyl)acetaldehyde + CO2 => 3-(4-hydroxyphenyl)pyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5681987", "l": "LC3 is cleaved by ATG4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61658", "l": "(2E,6E)-farnesyl phosphate + ADP + H(+) => (2E,6E)-farnesol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23352", "l": "2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde", "d": [], "t": []}, {"i": "EC:2.6.1.19", "l": "\"4-aminobutyrate--2-oxoglutarate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48012", "l": "4-methyl-5-nitrocatechol + NADPH + O2 = 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086090", "l": "voltage-gated potassium channel activity involved in SA node cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215406", "l": "PRMT5 binds WDR77 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42973", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a cardiolipin + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008910", "l": "kanamycin kinase activity", "d": ["Catalysis of the reaction: ATP + kanamycin = ADP + 2 H+ + kanamycin 3'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76656", "l": "3-methylbutanal + H2O + NAD(+) => 3-methylbutanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047923", "l": "gentisate decarboxylase activity", "d": ["Catalysis of the reaction: 2,5-dihydroxybenzoate + H+ = CO2 + hydroquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162186", "l": "COQ3 methylates DeMQ10H2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54153", "l": "a uridine in rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24637", "l": "H2 + NAD(+) => H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004399", "l": "histidinol dehydrogenase activity", "d": ["Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205238", "l": "SHP2 interacts with p-KIT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936380", "l": "Interaction of PIN1 with p-IRF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.96.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004107", "l": "chorismate synthase activity", "d": ["Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64339", "l": "H(+) + 2 malonyl-CoA + nicotinyl-CoA <=> 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421835", "l": "trans-Golgi Network Vesicle Scission (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174124", "l": "Dephosphorylation of phospho-Cdh1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209960", "l": "Diiodinated tyrosine can be deiodinated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75498", "l": "n H(+)(out) + pregnenolone sulfate(out) <=> n H(+)(in) + pregnenolone sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904288", "l": "BAT3 complex binding", "d": ["Binding to a BAT3 complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33548", "l": "H2O + lanosteryl hexadecanoate => H(+) + hexadecanoate + lanosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19086", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68919", "l": "ATP + butanoate + H(+) + NADPH <=> AMP + butanal + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374896", "l": "Uptake of Noradrenaline (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12561", "l": "hydroquinone + UDP-alpha-D-glucose => H(+) + hydroquinone O-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25577", "l": "3 O2 + protoporphyrinogen IX => 3 H2O2 + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57188", "l": "H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] = glycolate + H(+) + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68603", "l": "ORC5 binds ORC2:ORC3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45701", "l": "glycine betaine + H(+) + NADH + O2 => formaldehyde + H2O + N,N-dimethylglycine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749494", "l": "IKBIP binds IKBKB and CHUK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782286", "l": "METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627056", "l": "Procaspase 9 forms dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11179", "l": "kojibiose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61849", "l": "cholesterol + UDP-alpha-D-glucose => cholesteryl 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876484", "l": "NPC2 transfers CHOL to NPC1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111915", "l": "CAMK4 autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61094", "l": "acetate + L-citrulline => H2O + N(2)-acetyl-L-citrulline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24526", "l": "5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13489", "l": "(S)-canadine + H(+) + 2 O2 = berberine + 2 H2O2", "d": [], "t": []}, {"i": "EC:1.3.3.8", "l": "\"tetrahydroberberine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40319", "l": "O2 + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804266", "l": "CHEK2 phosphorylates TTC5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0042011", "l": "interleukin-16 binding", "d": ["Binding to interleukin-16."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76768", "l": "emodin + S-adenosyl-L-methionine => physcion + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63644", "l": "GDP-beta-L-fucose + L-seryl-[protein] = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75023", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate = 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57029", "l": "FADH2 + N-methylnicotinate + O2 => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156699", "l": "Inactivation of Wee1 kinase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16288", "l": "D-octopine + H2O + NAD(+) <=> H(+) + L-arginine + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50076", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190263", "l": "FGFR3b binds to FGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9859148", "l": "BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63374", "l": "an S-acyl-L-cysteinyl-[protein] + CoA => an acyl-CoA + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102201", "l": "(+)-2-epi-prezizaene synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-trans-farnesyl diphosphate = (+)-2-epi-prezizaene + diphosphoric acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.129", "l": "\"endo-alpha-sialidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-996727", "l": "REST recruits the BHC complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19490", "l": "dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide => 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13189", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.26", "l": "\"galactolipase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0060175", "l": "brain-derived neurotrophic factor receptor activity", "d": ["Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362522", "l": "ALDHs oxidise atRAL to atRA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22667", "l": "2 1-O-(trans-sinapoyl)-beta-D-glucose <=> 1,2-di-O-sinapoyl beta-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66553", "l": "L-glutaminyl-[protein] + serotonin => 5-serotonyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74929", "l": "(2E)-butenoyl-[ACP] + glycine + H2O => (3R)-3-[(carboxymethyl)amino]butanoate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64688", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-alpha-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392870", "l": "Gs activation by prostacyclin receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33951", "l": "ribostamycin + UDP-N-acetyl-alpha-D-glucosamine = 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.285", "l": "\"UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26548", "l": "beta-alanine + NH4(+) => beta-alaninamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10795", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43002", "l": "(1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58103", "l": "1-(15Z-tetracosenoyl)-glycerol + H2O <=> (15Z)-tetracosenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47023", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O <=> [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693561", "l": "RAD51 binds BRCA2 at resected DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25455", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37345", "l": "adenosine + phosphate => adenosine 2'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174255", "l": "Degradation multiubiquitinated Cyclin A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32383", "l": "(1S,2S,4R)-limonene-1,2-diol + NAD(+) = (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23268", "l": "guanidinoacetate + H2O = glycine + urea", "d": [], "t": []}, {"i": "EC:3.5.3.2", "l": "\"guanidinoacetase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77628", "l": "1-O-alkylglycerol + an acyl-CoA => 1-O-alkyl-3-acylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189488", "l": "UROS transforms HMB to URO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51750", "l": "4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57291", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O <=> a guanosine in RNA + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664879", "l": "ATM:PEX5 binds ATM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33948", "l": "2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine => 2'-N-acetylparomamine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928624", "l": "EPHBs bind EFNBs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399711", "l": "Activation of Ca impermeable AMPA receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30751", "l": "ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44848", "l": "(9Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)-tetradecenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31370", "l": "2 H(+) + 3 nitrite <=> H2O + nitrate + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16145", "l": "CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}, {"i": "EC:1.14.18.2", "l": "\"CMP-N-acetylneuraminate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9853376", "l": "FIGNL1 binds SPIDR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55414", "l": "[phosphate](n+1) + GDP => [phosphate](n) + GTP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214405", "l": "Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69947", "l": "3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096488", "l": "RRP8 binds RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160874", "l": "HYAL1 hydrolyses (HA)50 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64305", "l": "1-phenylpropylamine + pyruvate => 1-phenylpropan-1-one + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66532", "l": "ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] = diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25494", "l": "(-)-beta-phellandrene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034535", "l": "1,2-dihydroxy-8-methylnaphthalene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-8-methylnaphthalene + O2 = 2-hydroxy-8-methylchromene-2-carboxylate + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67886", "l": "adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+) => 3'-phosphoadenylyl sulfate + dopamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0016427", "l": "tRNA (cytidine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28976", "l": "H(+)(out) + L-asparagine(in) => H(+)(in) + L-asparagine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78853", "l": "a long-chain (2E)-enoyl-CoA + H2O2 => a long-chain 2,3-saturated fatty acyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45112", "l": "gamma-tocopherol + H(+) + NADPH + O2 = 13-hydroxy-gamma-tocopherol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0008946", "l": "oligonucleotidase activity", "d": ["Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74101", "l": "ADP + H(+) + L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693198", "l": "RHOD binds effectors at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1253343", "l": "WWOX binds ERBB4s80 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48830", "l": "benzene-1,2,4-triol + H2O + NADP(+) => H(+) + NADPH + O2 + resorcinol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22904", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] = gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73023", "l": "pregnenolone sulfate(out) = pregnenolone sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53568", "l": "12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74711", "l": "5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine = 5-dehydrofumagillol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.387", "l": "\"5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21956", "l": "UDP-alpha-D-glucose + vitexin = H(+) + UDP + vitexin 2''-O-beta-D-glucoside", "d": [], "t": []}, {"i": "EC:2.4.1.105", "l": "\"vitexin beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22058", "l": "H(+) + hexadecanal + NADH => hexadecan-1-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22712", "l": "adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.62", "l": "\"adenosylcobinamide-phosphate guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879942", "l": "The receptor is activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.15", "l": "\"cathepsin L\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725206", "l": "IgE binds FCERI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11233", "l": "3'-phosphoadenylyl sulfate + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57971", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.23", "l": "\"matrilysin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69208", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75691", "l": "2'-deoxyadenosine(in) = 2'-deoxyadenosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58859", "l": "(6E)-8-hydroxygeraniol + NAD(+) <=> (6E)-8-oxogeraniol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65760", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.3", "l": "\"D-amino-acid oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16657", "l": "H2O + inosine = D-ribose + hypoxanthine", "d": [], "t": []}, {"i": "EC:3.2.2.2", "l": "\"inosine nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19532", "l": "isovitexin + UDP-alpha-D-glucose <=> H(+) + isovitexin 2''-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070410", "l": "co-SMAD binding", "d": ["Binding to a common mediator SMAD signaling protein."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57319", "l": "ATP + cytidine 5'-diphosphoramidate <=> ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873946", "l": "OTUD3 deubiquitinates PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024361", "l": "Expression of ABCG1 regulated by NR1H2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902516", "l": "sn-glycerol 3-phosphate binding", "d": ["Binding to sn-glycerol 3-phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38344", "l": "(20S)-ginsenoside Rd + H2O => (20S)-ginsenoside Rg3 + D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75554", "l": "2 a (3R)-3-isocyanyl-fatty acyl-[ACP] + ATP + L-lysine + 2 NADPH <=> AMP + an isonitrile lipopeptide + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15560", "l": "ATP + H2O + Ni(2+)(out) <=> ADP + H(+) + Ni(2+)(in) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50928", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40208", "l": "(2E)-tetradecenedioyl-CoA + H2O => (3S)-hydroxytetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70692", "l": "ornithine => putrescine + CO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77775", "l": "acetyl-CoA + N(6)-methyl-L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-N(6)-methyl-L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49168", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.331", "l": "\"bacteriochlorophyllide d C-12(1)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69053", "l": "RFC binding displaces Pol Alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57426", "l": "catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => guaiacol + O2 + reduced [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55337", "l": "a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine => a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-178208", "l": "SMAD7 binds to SMURF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824579", "l": "MITF-M-dependent TYR gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193981", "l": "CYP21A2 oxidises 17HPROG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32305", "l": "(2R,3S)-homoisocitrate => (2R)-homocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17948", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28225", "l": "3-dehydro-L-gulonate + ATP <=> 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376122", "l": "DSCAM/DSCAML1 homodimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42099", "l": "ATP + carbamoyl phosphate + H2O + tobramycin <=> AMP + diphosphate + H(+) + nebramycin 5' + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420911", "l": "Formation of PPAT dimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18032", "l": "2 ATP + hydrogencarbonate + NH4(+) <=> 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806957", "l": "MET receptor dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65561", "l": "2-oxoglutarate + L-kynurenine => H2O + kynurenate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60512", "l": "a guanosine in miRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39615", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA = (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23176", "l": "acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.1", "l": "\"acetate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63158", "l": "docosanoate + taurine => H2O + N-docosanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018451", "l": "epoxide dehydrogenase activity", "d": ["Catalysis of the reaction: ethene oxide + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34857", "l": "N-(cyanomethyl)glycine + NH4(+) => 2 H2O + iminodiacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52035", "l": "H2O + L-isoleucine-(+)-7-isojasmonate <=> (+)-7-isojasmonate + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48003", "l": "1,6-dihydro-beta-NADP + H(+) + O2 <=> H2O2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68168", "l": "N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052848", "l": "inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity", "d": ["Catalysis of the reaction: 3,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013109", "l": "RHOC GEFs activate RHOC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390112", "l": "Phosphorylated HPO dimer phosphorylates WTS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24222", "l": "(4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54392", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50485", "l": "acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61100", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19612", "l": "adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25647", "l": "(R)-pulegone + H(+) + NADPH => (2R,5R)-isomenthone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53499", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018809", "l": "E-phenylitaconyl-CoA hydratase activity", "d": ["Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5340214", "l": "CYGB binds O2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48609", "l": "A + a 2,3-saturated acyl-CoA => a 2,3-dehydroacyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16032", "l": "3-guanidinopropanoate + H2O <=> beta-alanine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22152", "l": "a ubiquinone + D-glucose = a ubiquinol + D-glucono-1,5-lactone", "d": [], "t": []}, {"i": "EC:1.1.5.2", "l": "\"quinoprotein glucose dehydrogenase (PQQ, quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11962", "l": "(S)-2-succinylamino-6-oxoheptanedioate + L-glutamate => 2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54358", "l": "2-methylpropanal + CO2 => 3-methyl-2-oxobutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62943", "l": "H2O + N(4)-acetylcytosine <=> acetate + cytosine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080089", "l": "sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to a nitrogen atom on a sinapoyl spermidine molecule resulting in the formation of a disinapoyl spermidine derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.616479785166973", "identifiers": [{"i": "GO:0070567", "l": "cytidylyltransferase activity", "d": ["Catalysis of the transfer of a cytidylyl group to an acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18481", "l": "cyclohexylsulfamate + H2O = cyclohexylamine + sulfate", "d": [], "t": []}, {"i": "EC:3.10.1.2", "l": "\"cyclamate sulfohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419861", "l": "Melanospin is stimulated by light (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58950", "l": "4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174070", "l": "Association of Cdh1 with the APC/C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445064", "l": "Activation of Rac1 by VAV2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45037", "l": "3 Fe(III)-[cytochrome c] + hydroxylamine => 3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071160", "l": "cyanophycin synthetase activity (L-aspartate-adding)", "d": ["Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0043539", "l": "protein serine/threonine kinase activator activity", "d": ["Binds to and increases the activity of a protein serine/threonine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821486", "l": "HCFC1 binds SET1A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26477", "l": "beta-D-galactosyl-(1->4)-L-rhamnose + phosphate <=> alpha-D-galactose 1-phosphate + L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54350", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39025", "l": "an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72204", "l": "2 chloride(out) + hydrogencarbonate(in) => 2 chloride(in) + hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75280", "l": "an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-medium-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21163", "l": "acetyl-CoA + ADP + oxaloacetate + phosphate <=> ATP + citrate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75694", "l": "2'-deoxyadenosine(in) <=> 2'-deoxyadenosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618107", "l": "ATP binding to HSP90 triggers conformation change (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858475", "l": "TNFSF9 binds TNFRSF9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.149", "l": "\"20alpha-hydroxysteroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218822", "l": "CRK binds BCAR1 and or PXN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31143", "l": "(3S)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39677", "l": "3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA => (9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31278", "l": "(S)-3-hydroxy-2-methylpropanoate + NAD(+) <=> (S)-2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102247", "l": "malonyl-malonyl acyl carrier protein-condensing enzyme activity", "d": ["Catalysis of the reaction: 2 H+ + 2 a malonyl-[acp] = 2 carbon dioxide + an acetoacetyl-[acp] + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67045", "l": "A + asnovolin H => AH2 + chermesin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047714", "l": "galactolipase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58635", "l": "N-tetradecanoyl-(2S)-hydroxyglycine <=> glyoxylate + tetradecamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840401", "l": "DELE1(143-515) is released into the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35798", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine <=> H(+) + kanamycin A + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57932", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627107", "l": "XIAP binds CASP7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43353", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40729", "l": "a 1-acylglycerone 3-phosphate + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48537", "l": "1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O => 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25219", "l": "CoA + H(+) + N-acetylserotonin => acetyl-CoA + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61485", "l": "a cytidine in rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782416", "l": "TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54246", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66150", "l": "CoA + H(+) + N-(2-phenylethyl)acetamide => 2-phenylethylamine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983421", "l": "Journey of cargo through Golgi complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635854", "l": "GLI2,3 are degraded by the proteasome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65256", "l": "AH2 + O2 + verruculide C = A + H2O + verruculide C epoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44811", "l": "1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-10 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56759", "l": "5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54766", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+) => 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23200", "l": "H2O + N(6)-methyl-L-lysine + O2 = formaldehyde + H2O2 + L-lysine", "d": [], "t": []}, {"i": "EC:1.5.3.4", "l": "\"N(6)-methyl-lysine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176502", "l": "NEDD4L ubiquitinates SMAD2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30412", "l": "benzoyl-CoA + benzyl alcohol => benzyl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805470", "l": "AMPK phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.2", "l": "\"(S)-2-haloacid dehalogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45757", "l": "(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-176956", "l": "Formation of GINS complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1471322", "l": "Beta-defensins are secreted (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937792", "l": "RUNX3 binds SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12619", "l": "ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate => ATP + N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030170", "l": "pyridoxal phosphate binding", "d": ["Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33743", "l": "an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69949", "l": "3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61742", "l": "H(+) + steviolbioside + UDP => steviolmonoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019145", "l": "aminobutyraldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3244643", "l": "STING binds cyclic GMP-AMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16893", "l": "pyridine + S-adenosyl-L-methionine = N-methylpyridinium + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.87", "l": "\"pyridine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19338", "l": "2 hydroxylamine + 2 NAD(+) => 2 H(+) + hyponitrous acid + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62461", "l": "3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12887", "l": "GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp) => GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102285", "l": "1-deoxy-11-oxopentalenate oxygenase activity", "d": ["Catalysis of the reaction: 1-deoxy-11-oxopentalenate + O2 + NADPH + H+ = pentalenolactone D + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853801", "l": "PSPN binds RET:GFRA4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46791", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038131", "l": "neuregulin receptor activity", "d": ["Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47979", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37667", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.313", "l": "\"protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25769", "l": "2-oxobutanoate + CO2 => 3-carboxy-2-oxobutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37781", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2399913", "l": "atRAL binds to RBP2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043184", "l": "vascular endothelial growth factor receptor 2 binding", "d": ["Binding to a vascular endothelial growth factor receptor 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77875", "l": "(2S)-4-methyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]pentanoate + H(+) + H2O = 2-dehydro-D-glucose + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74652", "l": "CTP + N-acetyl-D-glucosamine => CDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22114", "l": "3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+) => isoxazolin-5-one + O-acetyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878178", "l": "The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034778", "l": "2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA = 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78324", "l": "glyoxylate + L-glutamine => 2-oxoglutaramate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61905", "l": "betaenone A + H(+) + NADPH + O2 => H2O + NADP(+) + stemphyloxin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848606", "l": "PTK6 phosphorylates PXN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40531", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428296", "l": "IGF2BP1 binds specific RNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046175", "l": "Further sulfation on galactose residues produces KSPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69383", "l": "2-hydroxy-4-methylpentanoate + O2 <=> 4-methyl-2-oxopentanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664664", "l": "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17614", "l": "NAD(+) + scyllo-inositol => H(+) + NADH + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30057", "l": "(2S)-2-amino-3-oxobutanoate + H(+) + NADPH => L-allo-threonine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209298", "l": "BSK is phosphorylated and activated by phosphorylated HEP kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34463", "l": "8-hydroxycopalyl diphosphate = cis-abienol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.140", "l": "\"cis-abienol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73676", "l": "ADP(out) + dAMP(in) + H(+)(out) => ADP(in) + dAMP(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58190", "l": "dihydroisopentenyldehydrorhodopin + diphosphate => all-trans-lycopene + dimethylallyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709360", "l": "H2O2 reduces MetHb (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40914", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18060", "l": "O2 + Watasenia luciferin <=> CO2 + hnu + oxidized Watasenia luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77794", "l": "an N-(1-deoxy-beta-D-fructopyranos-1-yl)amine + O2 <=> an (E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amine + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5684008", "l": "NBN binds KPNA2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66786", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein] => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79119", "l": "glycocholate + L-arginine = glycine + L-arginocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21275", "l": "ATP + glutathione + spermidine <=> ADP + glutathionylspermidine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204485", "l": "Basigin binds CyPA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110307", "l": "REV1 binds AP-dsDNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77499", "l": "2-phenylacetaldehyde + hydrogen cyanide = (2S)-2-hydroxy-3-phenylpropanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73682", "l": "3'-AMP(in) + ADP(out) + H(+)(out) <=> 3'-AMP(out) + ADP(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46549", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047874", "l": "dolichyldiphosphatase activity", "d": ["Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183067", "l": "Localization of CBL:GRB2 to the membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043833", "l": "[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase activity", "d": ["Catalysis of the reaction: [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M = [Co(I) methylamine-specific corrinoid protein] + H+ + methyl-coenzyme M. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37644", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52498", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106326", "l": "acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H+ + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003848", "l": "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51462", "l": "(9Z)-octadecenoate + L-glutamate => H2O + N-(9Z-octadecenoyl)-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050039", "l": "lactaldehyde reductase (NADPH) activity", "d": ["Catalysis of the reaction: NADP+ + propane-1,2-diol = (S)-lactaldehyde + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42447", "l": "L-aspartate + NADP(+) <=> H(+) + iminosuccinate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047828", "l": "D-lyxose ketol-isomerase activity", "d": ["Catalysis of the reaction: D-lyxose = D-xylulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218821", "l": "PDK1 phosphorylates PKC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66376", "l": "D-erythrose 4-phosphate + H2O = D-erythrose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418856", "l": "Activation of Rac1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681616", "l": "AP2 binds chlorpromazine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22129", "l": "(1S,2R,4S)-borneol + NAD(+) => (1S,4S)-camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192624", "l": "cRNA Extension (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-200406", "l": "CPT1A,B transfers PALM to CAR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19857", "l": "a 16alpha-hydroxysteroid + NADP(+) = a 16-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48174", "l": "a ganglioside GA2 + N-acetylneuraminate => a ganglioside GM2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53542", "l": "(13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine => (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72672", "l": "The 60S subunit joins the translation initiation complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75177", "l": "dADP + H(+) + NADP(+) => dATP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263444", "l": "Defective SGSH does not hydrolyse Heparan sulfate chain(7) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5591086", "l": "SERPINA5 binds activated protein C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21132", "l": "H2O + O2 + xanthine = H2O2 + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953037", "l": "E2F8 forms homodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71433", "l": "3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out) => 3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44644", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24641", "l": "ergosteryl 3-beta-D-glucoside + H2O => D-glucose + ergosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374662", "l": "Translocation of Ezrin to plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37569", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49920", "l": "(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27711", "l": "ATP + guanosine => ADP + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853405", "l": "TPX2 binds AURKA at centrosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48107", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149519", "l": "MMACHC decyanates CNCbl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59325", "l": "D-xylose + O2 => D-xylono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-374909", "l": "Catabolism of Noradrenaline (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23249", "l": "myo-inositol + S-adenosyl-L-methionine => 1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14965", "l": "an acyl phosphate + H2O = a carboxylate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.7", "l": "\"acylphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9709179", "l": "DPP4 binds DPP4 inhibitors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59300", "l": "3'-phosphoadenylyl sulfate + firefly D-luciferin = adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19289", "l": "H2O + sucrose 6(F)-phosphate = phosphate + sucrose", "d": [], "t": []}, {"i": "EC:3.1.3.24", "l": "\"sucrose-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14945", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.46", "l": "\"monogalactosyldiacylglycerol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22884", "l": "glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine", "d": [], "t": []}, {"i": "EC:2.6.1.73", "l": "\"methionine--glyoxylate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64054", "l": "CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine => (13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73223", "l": "(3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33353", "l": "CoA + H(+) + N-hexacosanoylsphinganine => hexacosanoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.12", "l": "\"alpha-lytic endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66696", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38752", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034855", "l": "4-AD 9alpha-hydroxylase activity", "d": ["Catalysis of the reaction: androst-4-ene-3,17-dione + O2 + 2 H+ + 2 e- = 9alpha-hydroxy-4-androstene-3,17-dione + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070123", "l": "transforming growth factor beta receptor activity, type III", "d": ["Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46743", "l": "7-dehydrodesmosterol + H(+) + NADPH <=> desmosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2545196", "l": "FN1 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41022", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24260", "l": "(3E)-2-oxohex-3-enedioate + H(+) = 2-oxopent-4-enoate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.77", "l": "\"2-oxo-3-hexenedioate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33159", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.54", "l": "\"N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0016414", "l": "O-octanoyltransferase activity", "d": ["Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668714", "l": "RAC1:GTP binds NOX1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21566", "l": "a 3-oxoacyl-CoA + CoA => acetyl-CoA + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71670", "l": "PKM dephosphorylates PEP to PYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72361", "l": "glutarate(out) + succinate(in) => glutarate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78374", "l": "H(+) + NADH + S-nitrosoglutathione <=> NAD(+) + sulfinamide glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41600", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36286", "l": "1,7-dimethylxanthine + H(+) + NADPH + O2 <=> 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689085", "l": "ATXN3 binds polyUb-PARK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37954", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202713", "l": "CD84 homodimerises (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.13", "l": "\"gamma-D-glutamyl-L-lysine dipeptidyl-peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57004", "l": "acetyl-CoA + streptothricin D = CoA + H(+) + N(beta)-acetylstreptothricin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205286", "l": "GRB2:SOS interacts with p-KIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112396", "l": "Separation of elongating transcript from template (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45741", "l": "2-oxoglutarate + L-ectoine + O2 => 5-hydroxyectoine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31378", "l": "H(+) + pyrrole-2-carboxylate <=> 1H-pyrrole + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26207", "l": "4-nitrocatechol + H2O + NADP(+) => 4-nitrophenol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69754", "l": "benzylmalonyl-CoA + H(+) + O2 <=> (E)-cinnamoyl-CoA + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45652", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928657", "l": "MMP2,9 cleave EPHB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710263", "l": "GZMB cleaves GSDME (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71239", "l": "2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047221", "l": "sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918227", "l": "Recruitment of TRAF3 to MAVS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.61", "l": "\"tubulin-glutamate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60171", "l": "a fatty acid + ATP <=> a fatty acyl phosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64246", "l": "an N-(fatty acyl)-glycine + CoA + H(+) => a fatty acyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33864", "l": "menaquinone-7 + succinate => fumarate + menaquinol-7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818010", "l": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer binds SRC family kinases FYN,HCK,SRC,YES1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "61.295603641503597", "identifiers": [{"i": "GO:0016853", "l": "isomerase activity", "d": ["Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804379", "l": "PRMT5 binds TTC5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0016493", "l": "C-C chemokine receptor activity", "d": ["Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49900", "l": "5,10-dihydrophenazine-1,6-dicarboxylate + O2 = H2O2 + phenazine-1,6-dicarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376851", "l": "SLC25A11 exchanges 2-OG and MAL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38290", "l": "(3S)-citramalate + succinyl-CoA <=> (3S)-citramalyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32933", "l": "a cardiolipin + CMP + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814734", "l": "CDSN binds the cornified envelope (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015089", "l": "high-affinity copper ion transmembrane transporter activity", "d": ["Enables the transfer of a copper ions (Cu2+) from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27388", "l": "H2O + maleamate <=> maleate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30021", "l": "ADP + H(+) + lipid A-core => ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64148", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GalNAc-R + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12215", "l": "9H-fluoren-9-ol + NADP(+) <=> 9H-fluoren-9-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22612", "l": "(3S)-citramalyl-CoA = acetyl-CoA + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.25", "l": "\"(S)-citramalyl-CoA lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18229", "l": "glycolate + NAD(+) = glyoxylate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.26", "l": "\"glyoxylate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954224", "l": "ERBB4s80:STAT5A binds CSN2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45837", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805981", "l": "HMGB1 release from cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56308", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.54", "l": "\"1,2-dehydroreticuline synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12276", "l": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.4", "l": "\"isovaleryl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77915", "l": "N-hydroxyhistamine + salicylmethyloxazolinyl-[peptidyl-carrier protein] = holo-[peptidyl-carrier protein] + pre-pseudomonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11909", "l": "H2O + nonane-4,6-dione => butanoate + H(+) + pentan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65531", "l": "hexan-1-ol + octanoyl-CoA <=> CoA + hexyl octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17753", "l": "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine", "d": [], "t": []}, {"i": "EC:4.4.1.21", "l": "\"S-ribosylhomocysteine lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936563", "l": "ISGylation of DDX58 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58486", "l": "acetate + sphing-4-enine => H2O + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67896", "l": "a 3'-end uridylyl-adenosine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350651", "l": "Caspase-mediated cleavage of MASK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-390329", "l": "Dephosphorylation of AKT by PP2A (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047568", "l": "3-oxo-5-beta-steroid 4-dehydrogenase activity", "d": ["Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21314", "l": "CO2 + hydroquinone => 2,5-dihydroxybenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31855", "l": "(S)-2,3-epoxysqualene = achilleol B", "d": [], "t": []}, {"i": "EC:5.4.99.48", "l": "\"achilleol B synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41700", "l": "1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35008", "l": "D-fucose(in) => D-fucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177491", "l": "Formation of clathrin-coated vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52568", "l": "epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140618", "l": "ferric-chelate reductase (NADH) activity", "d": ["Catalysis of the reaction: 2 Fe3+-siderophore + NAD+ + H+ -> 2 Fe2+-siderophore + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23685", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2219524", "l": "PDPK1 binds PIP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177934", "l": "EGFR autophosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.40", "l": "\"D-mannitol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41917", "l": "H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] => 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389348", "l": "Activation of Rac1 by pVav1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432129", "l": "FGR binds and phosphorylates LRP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74689", "l": "2 5'-deoxyadenosine + A + a macrocyclic archaeaol phospholipid + 2 H(+) + 2 L-methionine => a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76853", "l": "butan-2-one + H(+) + NADH + NH4(+) => (S)-sec-butylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050074", "l": "malate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65230", "l": "H(+) + NADPH + naphthalene-1,2-diol => (1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14842", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.266", "l": "\"glucosyl-3-phosphoglycerate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71579", "l": "CDP(out) + CDP-L-ribitol(in) = CDP(in) + CDP-L-ribitol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25578", "l": "3 H2O2 + protoporphyrin IX => 3 O2 + protoporphyrinogen IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64882", "l": "CMP + H(+) + phosphate => CDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004303", "l": "estradiol 17-beta-dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53726", "l": "ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate => ATP + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73037", "l": "Co(2+)(in) + H(+)(in) => Co(2+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029984", "l": "Autocatalytic phosphorylation of FGFR2 ligand-independent  mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22479", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981621", "l": "Neuroglobin:oxygen dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68364", "l": "4-CDP-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64460", "l": "acetyl phosphate + L-lysyl-[protein] = H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53052", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate = 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72103", "l": "Formation of pre-mRNPs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169192", "l": "PTP1B dephosphorylates GHR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78081", "l": "a 1-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acid + H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102422", "l": "curcumin-4'-O-beta-D-gentiotrioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: curcumin 4'-O-beta-D-gentiotrioside + UDP-alpha-D-glucose = curcumin 4'-O-beta-D-gentiotetraside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9859172", "l": "DLD dimer dehydrogenates dihydrolipoyl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828205", "l": "TBK1 is phosphorylated within the activated TLR3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004023", "l": "alcohol dehydrogenase (NAD+) activity, metal ion-independent", "d": ["Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44484", "l": "3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791128", "l": "Expression of LMNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59912", "l": "(E)-4-hydroxynon-2-enal + H2O + NADP(+) = (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66377", "l": "D-erythrose 4-phosphate + H2O => D-erythrose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.371808729290493", "identifiers": [{"i": "GO:0030674", "l": "protein-macromolecule adaptor activity", "d": ["The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49371", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) <=> 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850997", "l": "TRIM27 binds PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793666", "l": "MDM2 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13889", "l": "FAD + H2O = AMP + FMN + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.18", "l": "\"FAD diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61095", "l": "H2O + N(2)-acetyl-L-citrulline <=> acetate + L-citrulline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63995", "l": "5-fluorocytidine + ATP <=> 5-fluorocytidine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373748", "l": "SEMA4D interacts with CD72 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32498", "l": "(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68682", "l": "3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30280", "l": "2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391158", "l": "SIRP alpha binds CD47 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.-", "l": "\"With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62478", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+) => 3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50801", "l": "glutathione + prostaglandin A2 => prostaglandin A2-S-(S)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961636", "l": "E2F1 binds the POLA1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21707", "l": "H2O + L-tyrosine <=> NH4(+) + phenol + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16870", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46762", "l": "4-methyl-5-nitrocatechol + NAD(+) + nitrite => 2,4-dinitrotoluene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74699", "l": "(5R)-hydroxy-beta-trans-bergamotene + O2 = (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714483", "l": "RAC2 translocates to the ER membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22764", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.36", "l": "\"phosphoinositide 5-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001051", "l": "plastid single-subunit type RNA polymerase binding", "d": ["Binding to a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689861", "l": "Recruitment of XPA and release of CAK  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53982", "l": "(11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807565", "l": "GNLY is transferred to the phagosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41234", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45651", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53977", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43922", "l": "(25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16241", "l": "an NDP-alpha-D-glucose + D-fructose = a ribonucleoside 5'-diphosphate + H(+) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39121", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2 => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849463", "l": "PTK6 phosphorylates SFPQ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30216", "l": "a menaquinol + 2 nitric oxide => a menaquinone + H2O + nitrous oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65951", "l": "a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 <=> A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45521", "l": "phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047619", "l": "acylcarnitine hydrolase activity", "d": ["Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42002", "l": "an isogloboside iGb3Cer (d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106379", "l": "8-oxo-(d)RTP hydrolase activity", "d": ["Catalysis of the reaction: 8-oxo-(d)RTP + H20 = 8-oxo-(d)RMP + diphosphate + H+."], "t": []}, {"i": "REACT:R-HSA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030331", "l": "nuclear estrogen receptor binding", "d": ["Binding to a nuclear estrogen receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811508", "l": "ING2-bound EP300 acetylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30708", "l": "putrescine + pyruvate => 4-aminobutanal + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15417", "l": "L-arogenate + NADP(+) = CO2 + L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54391", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66589", "l": "a cytidine in 26S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54762", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate => ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70811", "l": "4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate = D-xylulose 5-phosphate + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31153", "l": "2-oxobutanoate + L-selenocysteine + NH4(+) => H2O + L-selenocystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27547", "l": "anthranilate + FADH2 + O2 => 3-hydroxyanthranilate + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9621179", "l": "Cinaciguat binds sGC:NO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42252", "l": "H(+) + malonyl-[ACP] + pentanoyl-CoA = 3-oxoheptanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29827", "l": "Mg(2+)(in) = Mg(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179417", "l": "Multiubiquitination of Nek2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791118", "l": "Expression of ASNS (Asparagine Synthetase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40902", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9861725", "l": "PGAM5 dodecamer dephosphorylates p-S336-ME1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48096", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.319", "l": "\"type I protein arginine methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295613", "l": "SPRY2 binds GRB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48874", "l": "a gentamycin 2''-phosphate + GDP + H(+) => a gentamycin + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36683", "l": "hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}, {"i": "EC:2.3.1.225", "l": "\"protein S-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.202", "l": "\"endo-chitodextinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534096", "l": "METAP1/2 demethylates GNAT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372723", "l": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] <=> phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22736", "l": "5-formimidoyltetrahydrofolate + 2 H(+) = (6R)-5,10-methenyltetrahydrofolate + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.4", "l": "\"formimidoyltetrahydrofolate cyclodeaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69061", "l": "N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2 => H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44614", "l": "2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017065", "l": "single-strand selective uracil DNA N-glycosylase activity", "d": ["Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA."], "t": []}, {"i": "REACT:R-HSA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71906", "l": "guanine + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-guanine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67561", "l": "3'-phosphoadenylyl sulfate + taurocholate => adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67415", "l": "alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49608", "l": "2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) = 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205321", "l": "Interaction of KIT and sSCF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0097364", "l": "stretch-activated, monoatomic cation-selective, calcium channel activity involved in regulation of action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674019", "l": "BRAP binds KSR1:MARK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451310", "l": "Activation of Edited Kainate receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141439", "l": "Release of activated MAD2 from kinetochores (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52946", "l": "choloyl-24-O-(beta-D-glucuronate) + UDP => cholate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9842671", "l": "Active LTK binds IRS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120225", "l": "coenzyme A binding", "d": ["Binding to coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52023", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 <=> A + H2O + resolvin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24595", "l": "CTP + H(+) + phosphoethanolamine <=> CDP-ethanolamine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622415", "l": "RIP2 binds NEMO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40464", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55751", "l": "coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703430", "l": "FLT3 fusions:GRB2 bind SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052601", "l": "limonene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + limonene-1,2-epoxide. Can use either (4S)-limonene or (4R)-limonene as substrate. NADPH can act instead of NADH, although more slowly."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038177", "l": "death receptor agonist activity", "d": ["Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421508", "l": "Synthesis of ALAS1 nascent polypeptide (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25517", "l": "an acyl-CoA + tropine => CoA + H(+) + O-acyltropine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664879", "l": "ATM:PEX5 binds ATM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9854672", "l": "FAD attaches to SDHA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160121", "l": "bis(monoacylglycero)phosphate synthase activity", "d": ["Catalysis of the reaction: 2 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)."], "t": []}, {"i": "RHEA:77619", "l": "2 a 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) = a 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864569", "l": "WWOX binds TFAP2C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67103", "l": "fumigatonoid B <=> fumigatonoid C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55372", "l": "H2O + methyl (-)-jasmonate = H(+) + jasmonate + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48127", "l": "a ganglioside GD3 (d18:1(4E)) + H2O <=> a ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.884407581586458", "identifiers": [{"i": "GO:0005179", "l": "hormone activity", "d": ["The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77239", "l": "pre-pseudomonine = pseudomonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445700", "l": "Myosin Binds ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734730", "l": "ORC1 translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66226", "l": "asc-DeltaC9-CoA + H2O2 => asc-C9-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047350", "l": "glucuronate-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = diphosphate + UDP-alpha-D-glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071209", "l": "U7 snRNA binding", "d": ["Binding to a U7 small nuclear RNA (U7 snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73309", "l": "H(+)(out) + L-aspartate(in) + phosphate(out) => H(+)(in) + L-aspartate(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19176", "l": "H(+) + NADH + naphthalene + O2 <=> (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35432", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside => cyanidin 3,7-di-O-beta-D-glucoside + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44927", "l": "2-oxoadipate + acetyl-CoA + H2O <=> (R)-dihomocitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102634", "l": "1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) activity", "d": ["Catalysis of the reaction: naphthalene-1,3,6,8-tetrol + O2 = flaviolin-2-olate + H2O + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69656", "l": "H2O + quercetin 3-O-beta-D-glucoside => beta-D-glucose + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018795", "l": "2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity", "d": ["Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635841", "l": "GLI proteins are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985943", "l": "p-Y701-STAT1 dimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1235035", "l": "Expression of Carbonic Anhydrase IX (CA9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28711", "l": "H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) = H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043798", "l": "glycerate 2-kinase activity", "d": ["Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22156", "l": "GDP + H2O = GMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51426", "l": "ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate => a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55744", "l": "coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}, {"i": "EC:1.8.98.4", "l": "\"coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28210", "l": "H2O + L-saccharopine + O2 = (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate", "d": [], "t": []}, {"i": "EC:1.5.3.18", "l": "\"L-saccharopine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50935", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111883", "l": "Hydrolysis of phosphatidylcholine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018472", "l": "1-hydroxy-2-naphthaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11454", "l": "H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36701", "l": "8-desmethylnovobiocic acid + AMP + diphosphate => 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22257", "l": "a (3R)-3-hydroxyacyl-CoA + NADP(+) => a 3-oxoacyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211924", "l": "CYP4B1 12-hydroxylates ARA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683429", "l": "nsp16 binds nsp10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28364", "l": "dGMP + diphosphate + H(+) => dGTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.61", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54039", "l": "[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) <=> [mycoredoxin]-S-mycothiol-L-cysteine + arsenite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75684", "l": "(12R,13S)-epoxy-(9Z)-octadecenoate + O2 => (12R,13S)-epoxy-(10R)-hydroperoxy-(8E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009940", "l": "amino-terminal vacuolar sorting propeptide binding", "d": ["Binding to an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48785", "l": "D-erythrulose 4-phosphate => D-erythrose 4-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050175", "l": "phenylalanine dehydrogenase activity", "d": ["Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9717841", "l": "holo-FDPS dimer binds NBPs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16148", "l": "CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35645", "l": "a 2-oxocarboxylate + H(+) + NADH => a (2R)-2-hydroxycarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-573296", "l": "Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004832", "l": "valine-tRNA ligase activity", "d": ["Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629483", "l": "NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51754", "l": "a 2-acyl-4-prenylphloroglucinol + diphosphate => a 2-acylphloroglucinol + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010420", "l": "3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454928", "l": "ABCG4 may mediate cholesterol efflux (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781899", "l": "USP13 binds SIAH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0015407", "l": "ABC-type monosaccharide transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16527", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+) => 2-dehydro-3-deoxy-D-galactonate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202216", "l": "Phosphorylation of SLP-76 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990931", "l": "mRNA N6-methyladenosine dioxygenase activity", "d": ["Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299481", "l": "TIMM9:TIMM10 binds hydrophobic proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35353", "l": "(2E)-octadecenoyl-CoA + H(+) + NADPH => NADP(+) + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691150", "l": "TFR2 dimer binds 2xholoTF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38164", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17989", "l": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14272", "l": "2 a quinone + H(+) + NADPH <=> 2 a 1,4-benzosemiquinone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.8", "l": "\"ribonuclease V\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21750", "l": "H(+) + methylglyoxal + NADPH => (S)-lactaldehyde + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54263", "l": "2-oxoglutarate + L-asparaginyl-[protein] + O2 <=> (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72834", "l": "3',3'-cGAMP + H2O <=> G[3'-5']pAp[3'] + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67198", "l": "acetate + serotonin => H2O + N-acetylserotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052860", "l": "2'-deoxymugineic-acid 3-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76146", "l": "picrinine + S-adenosyl-L-methionine <=> ervincine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697086", "l": "Rifampicin binds Mtb RNAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162657", "l": "Inactivation of Myt1 kinase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114352", "l": "Sequestration of tBID by BCL-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689544", "l": "UCHL5 binds INO80 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57218", "l": "N(2)-(1-hydroxy-2-oxoethyl)-dGTP => dGTP + glyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10146", "l": "a ribonucleoside + phosphate => a ribonucleoside 3'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76148", "l": "perivine + S-adenosyl-L-methionine => 2 H(+) + S-adenosyl-L-homocysteine + vobasine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2514790", "l": "Elastin degradation by MMP14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66662", "l": "ADP + beta-D-glucosylceramide(out) + H(+) + phosphate => ATP + beta-D-glucosylceramide(in) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753634", "l": "GGT dimers hydrolyse APAP-SG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76591", "l": "N,N-dimethylglycine(out) + Na(+)(out) = N,N-dimethylglycine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052883", "l": "tyrosine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-tyrosine = NH4 + trans-4-coumarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73256", "l": "(2S)-sakuranetin + S-adenosyl-L-methionine => (2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389463", "l": "Proteinase-activated receptors can bind thrombin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49135", "l": "an adenosine in tRNA + S-adenosyl-L-methionine <=> an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66027", "l": "hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] <=> [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54610", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein] => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17959", "l": "H2O + propynoate => 3-oxopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70655", "l": "L-glutamate gamma-semialdehyde <=> L-1-pyrroline-5-carboxylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77068", "l": "Activation of GT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016403", "l": "dimethylargininase activity", "d": ["Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37195", "l": "octadecanoyl-CoA + sn-glycerol 3-phosphate = 1-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78360", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40036", "l": "ATP + L-glutamate + N-acetyl-L-aspartate => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380930", "l": "Phosphorylated AMPK binds AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2152276", "l": "Secretion of transmembrane collagens (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649733", "l": "mature p21 RAS binds GDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39754", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25559", "l": "9alpha-copalyl diphosphate <=> diphosphate + stemod-13(17)-ene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650165", "l": "ASIC trimers bind H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2530445", "l": "CD59 inhibits MAC formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59194", "l": "diphosphate + icosanoyl-AMP => ATP + eicosanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62208", "l": "3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] = 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.1", "l": "\"cathepsin B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65825", "l": "dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570528", "l": "SUMOylation of XPC with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018574", "l": "2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73287", "l": "(2S)-naringenin + S-adenosyl-L-methionine = (2S)-naringenin 4'-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35942", "l": "brevianamide F + dimethylallyl diphosphate <=> diphosphate + tryprostatin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44216", "l": "12-hydroxyoctadecanoate + ATP + CoA = 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56646", "l": "a pseudouridine in mRNA => a uridine in mRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15602", "l": "(E)-cinnamoyl-CoA + (R)-3-phenyllactate => (E)-cinnamate + (R)-3-phenyllactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202203", "l": "Recruitment of PI3K to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31229", "l": "di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP => di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56997", "l": "aldehydo-D-apiose => apulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844057", "l": "SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.4", "l": "\"minus-end-directed kinesin ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676589", "l": "RANKL,sRANKL trimer binds RANK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21976", "l": "[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate", "d": [], "t": []}, {"i": "EC:1.8.4.10", "l": "\"adenylyl-sulfate reductase (thioredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062213", "l": "peroxynitrite isomerase activity", "d": ["Catalysis of the reaction: peroxynitrite = nitrate."], "t": []}, {"i": "RHEA:63116", "l": "peroxynitrite = nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56061", "l": "H(+) + hexadecanoate + hnu => CO2 + pentadecane", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.13", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.295", "l": "\"momilactone-A synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22669", "l": "2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H(+) + lipid A disaccharide (E. coli) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44743", "l": "27-O-demethylrifamycin SV + S-adenosyl-L-methionine <=> H(+) + rifamycin SV + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10760", "l": "citrate = acetate + oxaloacetate", "d": [], "t": []}, {"i": "EC:4.1.3.6", "l": "\"citrate (pro-3S)-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30745", "l": "D-ribose + H(+) + nicotinamide => beta-nicotinamide D-riboside + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16922", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047237", "l": "glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76085", "l": "(11R)-19-hydroxycarlactone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (11R)-carlactone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2317314", "l": "AKT binds PDPK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47933", "l": "(2S)-3-sulfolactaldehyde + H2O + NAD(+) => (2S)-3-sulfolactate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23291", "l": "acetaldehyde + CoA + NAD(+) <=> acetyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0017099", "l": "very-long-chain fatty acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37019", "l": "A + D-serine + H2O = 3-hydroxypyruvate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29660", "l": "O-acetyl-L-serine(in) => O-acetyl-L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74306", "l": "12alpha-hydroxy-3-oxochola-4-en-24-oate + NAD(+) <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694583", "l": "ABHD4 hydrolyses NAPE (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17525", "l": "biuret + H2O = NH4(+) + urea-1-carboxylate", "d": [], "t": []}, {"i": "EC:3.5.1.84", "l": "\"biuret amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008777", "l": "acetylornithine deacetylase activity", "d": ["Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692867", "l": "HRH3 binds pitosilant (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28295", "l": "(2E,6E)-farnesyl diphosphate => (-)-(E)-beta-caryophyllene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033705", "l": "GDP-4-dehydro-6-deoxy-D-mannose reductase activity", "d": ["Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685607", "l": "Sialic acid binds SIGLEC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62813", "l": "4 monapinone A + O2 => 2 dinapinone A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72969", "l": "4-methyl-2-oxopentanoate(in) + 2 Na(+)(in) => 4-methyl-2-oxopentanoate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625416", "l": "Anterograde IFT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61567", "l": "a tetracycline + H(+) + NADPH + O2 <=> a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432010", "l": "Aquaporin-1 passively transports water into cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20016", "l": "carbamoyl phosphate + L-aspartate <=> H(+) + N-carbamoyl-L-aspartate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0055102", "l": "lipase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807106", "l": "PTEN undergoes monoubiquitination (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35916", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56480", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051537", "l": "2 iron, 2 sulfur cluster binding", "d": ["Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46940", "l": "AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] = ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5623643", "l": "RDH13 reduces atRAL to atROL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028598", "l": "Phosphorylation of YAP by LATS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209792", "l": "N-acetylation of serotonin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166223", "l": "The proton is delivered to the matrix side (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67644", "l": "ATP + dZDP = ADP + dZTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611147", "l": "Endocytic Uptake of HCMV Virion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0019136", "l": "deoxynucleoside kinase activity", "d": ["Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629189", "l": "TP53 stimulates expression of SESN1,2,3 genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785524", "l": "Defective C1GALT1C1 does not bind C1GALT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54141", "l": "cytidine(49) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15094", "l": "2-oxoglutarate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209133", "l": "Formation of the 'destruction complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193641", "l": "IKK-beta is recruited (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047488", "l": "heparin lyase activity", "d": ["Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70883", "l": "H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out) = H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76499", "l": "N-acetyl-D-glutamate = N-acetyl-L-glutamate", "d": [], "t": []}, {"i": "EC:5.1.1.25", "l": "\"N-acetyl-D-glutamate racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27452", "l": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050261", "l": "ribose isomerase activity", "d": ["Catalysis of the reaction: ribofuranose = D-ribulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59682", "l": "D-maltopentaono-1,5-lactone + H2O2 => D-maltopentaose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10036", "l": "4-hydroxy-3-methoxy-benzenemethanol + O2 = H2O2 + vanillin", "d": [], "t": []}, {"i": "EC:1.1.3.38", "l": "\"vanillyl-alcohol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354124", "l": "Phosphorylation of pPTK2 by SRC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0071207", "l": "histone pre-mRNA stem-loop binding", "d": ["Binding to a conserved stem-loop structure found in histone pre-mRNAs."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005340", "l": "nucleotide-sulfate transmembrane transporter activity", "d": ["Enables the transfer of nucleotide-sulfate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944247", "l": "Association of procollagen type VI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58715", "l": "NADH + O2 + rifampicin <=> H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19033", "l": "an N-acyl-D-glucosamine = an N-acyl-D-mannosamine", "d": [], "t": []}, {"i": "EC:5.1.3.8", "l": "\"N-acylglucosamine 2-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23905", "l": "an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] => 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784204", "l": "JAKs bind OSMR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69738", "l": "phenylsuccinate + succinyl-CoA <=> 2-phenylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191763", "l": "snRNP:Snurportin complex formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014296", "l": "RAC2 GEFs activate RAC2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167427", "l": "Opioid dissociates from MOR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31335", "l": "CTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin cytosine dinucleotide", "d": [], "t": []}, {"i": "EC:2.7.7.76", "l": "\"molybdenum cofactor cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17740", "l": "NADP(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004045", "l": "aminoacyl-tRNA hydrolase activity", "d": ["Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9854672", "l": "FAD attaches to SDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791186", "l": "Expression of ZBTB17 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73797", "l": "FAICAR => IMP + H2O (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21635", "l": "2 catechol + O2 <=> 2 1,2-benzoquinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351429", "l": "Association of 53BP1 with gamma H2AX at double strand break (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987120", "l": "JAK1 binds IFNLR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031765", "l": "type 2 galanin receptor binding", "d": ["Binding to a type 2 galanin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672948", "l": "MARK3 phosphorylates KSR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54444", "l": "a (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)-dihydroflavonol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23935", "l": "an N-acyl-D-glucosamine 6-phosphate <=> an N-acyl-D-mannosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47799", "l": "an aralkylamine + H2O + 2 oxidized [azurin] <=> an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018596", "l": "dimethylsilanediol hydroxylase activity", "d": ["Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41389", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70504", "l": "H2O + isopentenyl diphosphate => H(+) + isopentenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70596", "l": "GOT2 dimer deaminates L-Asp (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2167942", "l": "Collagen type XIII ectodomain shedding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74408", "l": "2 (S)-lactate(in) + thromboxane B2(out) => 2 (S)-lactate(out) + thromboxane B2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38923", "l": "a ubiquinone + H(+) + Na(+)(in) + NADH = a ubiquinol + Na(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685838", "l": "CX3 complex binds D-loop structures (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74734", "l": "Re-integration of insulin receptor into plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58113", "l": "1''-O-acetyl-ADP-alpha-D-ribose + H2O => acetate + ADP-D-ribose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34239", "l": "L-glutamate = 3-aminopentanedioate", "d": [], "t": []}, {"i": "EC:5.4.3.9", "l": "\"glutamate 2,3-aminomutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38173", "l": "2-hydroxyhexadecyl hexadecanoate + CoA => hexadecane-1,2-diol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749977", "l": "UGT1A6 glucuronates ST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24882", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) = H(+) + L-glutamate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64263", "l": "(9Z,12Z)-octadecadienoyl-CoA + glycine <=> CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36551", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol = 3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63168", "l": "fumarate + L-cysteine = S-(2-succino)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54066", "l": "10-epi-cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-996755", "l": "ZFPM proteins bind GATA proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391942", "l": "IP receptor can bind prostacyclin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19460", "l": "2-nitrophenol + 2 H(+) + 2 NADPH + O2 <=> catechol + H2O + 2 NADP(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296326", "l": "HCAR1 binds LACT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26556", "l": "angiotensin-(1-7) + L-phenylalanine => angiotensin II + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44050", "l": "8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13551", "l": "diphosphate + GDP-beta-L-fucose => beta-L-fucose 1-phosphate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939335", "l": "RNF181 polyubiquinates BCL10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615910", "l": "SUMOylation of PCNA with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210805", "l": "Removal of miRNA passenger strand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48171", "l": "H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine <=> N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40723", "l": "(9E)-octadecenoyl-CoA + H2O = (9E)-octadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624951", "l": "TNPO1 binds KIF17 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14731", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => beta-D-fructose 1,6-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76227", "l": "(Z)-(indol-3-yl)-N-(sulfonatooxy)methanimidothioate = (indol-3-yl)acetonitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34464", "l": "8-hydroxycopalyl diphosphate => cis-abienol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44072", "l": "1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114256", "l": "CYCS:APAF1 binds procaspase-9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372422", "l": "oxaloacetate + NADH + H+ <=> malate + NAD+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53038", "l": "4-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66471", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> (17E)-cheilanthenediol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109702", "l": "PDPK1 phosphorylates AKT2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9769235", "l": "MAGED1 binds NPAS4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008762", "l": "UDP-N-acetylmuramate dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8934465", "l": "SHC1 binds PTPN12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32335", "l": "(1S,2S,4R)-endo-fenchol + NADP(+) = (1S,4R)-fenchone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26117", "l": "diphosphate + epi-cedrol => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65074", "l": "dauca-4,7-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77209", "l": "3alpha-sulfoglycodeoxycholate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + glycodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204485", "l": "Basigin binds CyPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39783", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371527", "l": "HSF1 trimer translocates to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.2.-", "l": "\"Amide--thiol ligases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53880", "l": "ADP-alpha-D-glucose + D-glucose 6-phosphate = ADP + alpha,alpha-trehalose 6-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.347", "l": "\"alpha,alpha-trehalose-phosphate synthase (ADP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.57", "l": "\"isopullulanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77018", "l": "(S)-leucinol + H2O + NAD(+) <=> 1-hydroxy-4-methylpentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021847", "l": "CREB1 gene expression is stimulated by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25982", "l": "albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76235", "l": "a tRNA with a 3' CCA end + ATP + 2 CTP = a tRNA with a 3' CCACCA end + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30174", "l": "hexadecanoyl-[ACP] + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16697", "l": "A + H2O + quinaldate = AH2 + kynurenate", "d": [], "t": []}, {"i": "EC:1.3.99.18", "l": "\"quinaldate 4-oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45916", "l": "12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62609", "l": "glutathione + H(+) + hydrogen sulfide + ubiquinone-10 => S-sulfanylglutathione + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71234", "l": "2 Fe(3+)-[Dph3] + NADH <=> 2 Fe(2+)-[Dph3] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186798", "l": "GAP binds to PDGF-beta receptors only (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29597", "l": "H(+) + NADPH + sulfoacetyl-CoA => CoA + NADP(+) + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62418", "l": "4-hydroxybenzaldehyde + acetyl-CoA => (E)-4-coumaroyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693092", "l": "Unknown deacetylase deacetylates 7K-BACE1(46-501) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.-.-", "l": "\"Other oxidoreductases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013435", "l": "RHOD auto-activates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75449", "l": "(9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012016", "l": "FAHD1 dimer hydrolyses OA to PYR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53770", "l": "allocholoyl-CoA + allodeoxycholate => allocholate + allodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29743", "l": "2-phenylethylamine(in) = 2-phenylethylamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209792", "l": "N-acetylation of serotonin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52889", "l": "N-phenylhydroxylamine + NADP(+) => H(+) + NADPH + nitrosobenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028598", "l": "Phosphorylation of YAP by LATS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18285", "l": "an N-acyl-D-aspartate + H2O = a carboxylate + D-aspartate", "d": [], "t": []}, {"i": "EC:3.5.1.83", "l": "\"N-acyl-D-aspartate deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800315", "l": "MST1 binds MST1R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034575", "l": "4-isopropylaniline dehydrogenase activity", "d": ["Catalysis of the reaction: 4-isopropylaniline + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25889", "l": "dihydroxyacetone phosphate + iminosuccinate => H(+) + 2 H2O + phosphate + quinolinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26074", "l": "H2O + UDP-alpha-D-glucuronate => D-glucuronate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20831", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61040", "l": "(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] = (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11320", "l": "UDP-beta-L-arabinopyranose = UDP-alpha-D-xylose", "d": [], "t": []}, {"i": "EC:5.1.3.5", "l": "\"UDP-arabinose 4-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42596", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047376", "l": "all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity", "d": ["Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53630", "l": "(2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044594", "l": "17-beta-hydroxysteroid dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20151", "l": "3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + quinine + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74272", "l": "an alpha-Kdo-(2->6)-lipid IVA + ATP => a 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426223", "l": "Cation influx mediated by TRPC3/6/7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46805", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine => a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50263", "l": "11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione <=> (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5671737", "l": "p-T774-PKN1 binds CDC25C (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004239", "l": "initiator methionyl aminopeptidase activity", "d": ["Catalysis of the release of N-terminal initiator methionine from peptides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10240", "l": "a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.9", "l": "\"enoyl-[acyl-carrier-protein] reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44090", "l": "AMP + diphosphate + heptanoyl-CoA => ATP + CoA + heptanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53687", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 <=> 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51024", "l": "H(+) + NADH + O2 + toluene-4-sulfonate = 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67484", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}, {"i": "EC:3.6.1.62", "l": "\"5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42208", "l": "a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 = a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.237", "l": "\"aliphatic glucosinolate S-oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070835", "l": "chromium ion transmembrane transporter activity", "d": ["Enables the transfer of chromium (Cr) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76769", "l": "physcion + S-adenosyl-L-homocysteine => emodin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822734", "l": "Caplacizumab binds VWF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682010", "l": "ATG10:ATG12 binds ATG5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750942", "l": "USP14 deubiquitinates NLRC5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26332", "l": "(8S)-8-amino-7-oxononanoate + L-lysine <=> (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654422", "l": "Activated FGFR4 binds FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.160", "l": "\"caffeine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047338", "l": "UTP:xylose-1-phosphate uridylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-xylose 1-phosphate + UTP = UDP-D-xylose + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.042693372152272", "identifiers": [{"i": "GO:0060589", "l": "nucleoside-triphosphatase regulator activity", "d": ["Binds to and modulates the activity of an NTPase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004160", "l": "dihydroxy-acid dehydratase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814088", "l": "SYS1 binds AcM-ARFRP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15504", "l": "2 L-glutamate + NADP(+) <=> 2-oxoglutarate + H(+) + L-glutamine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39710", "l": "a long-chain fatty acyl-CoA(out) <=> a long-chain fatty acyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18940", "l": "an N-acyl-L-homoserine lactone + H2O <=> a carboxylate + L-homoserine lactone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15083", "l": "acetyl-CoA + ADP + phosphate => acetate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983424", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754964", "l": "ADA deamidates RBV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36376", "l": "ATP + carbamoyl phosphate + H2O => carbamoyl adenylate + diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34983", "l": "sulfate(in) = sulfate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67016", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1671687", "l": "PRLR activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31253", "l": "(S)-3-hydroxy-2-methylpropanoate + CoA + H(+) => (S)-3-hydroxyisobutanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12952", "l": "D-fuconate <=> 2-dehydro-3-deoxy-D-fuconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29496", "l": "(2E,6E)-farnesyl diphosphate + H2O => beta-eudesmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2429719", "l": "MCPH1 sequesters condensin II (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64220", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51053", "l": "5alpha-androstan-3,17-dione + A => 5alpha-androst-1-ene-3,17-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047220", "l": "galactosylxylosylprotein 3-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26255", "l": "2 H2O + isopimara-7,15-dienal + NADP(+) => H(+) + isopimara-7,15-dienol + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001918", "l": "farnesylated protein binding", "d": ["Binding to a farnesylated protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801675", "l": "PLK2 phosphorylates NPM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69250", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+) => H2O + sinigrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39808", "l": "octadecanoate(in) => octadecanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466238", "l": "BGN binds Collagen types II, III (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.1", "l": "\"ribonucleoside-diphosphate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70833", "l": "L-arginine(out) + L-leucine(in) + Na(+)(in) => L-arginine(in) + L-leucine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61593", "l": "H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine => 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49954", "l": "5,10-dihydrophenazine 1-carboxylate => (10aS)-10,10a-dihydrophenazine-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49799", "l": "an N-(fatty acyl)-glycine + H2O <=> a fatty acid + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35419", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.297", "l": "\"anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708457", "l": "HM13 cleaves HMOX1 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332359", "l": "Active calmodulin binds CAMK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25054", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33133", "l": "3-phenylpyruvate + tetrahydrotyrosine => L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33163", "l": "beta-nicotinamide D-riboside(in) = beta-nicotinamide D-riboside(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809354", "l": "NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008177", "l": "RUNX2 binds HEY1,HEY2,HES1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174124", "l": "Dephosphorylation of phospho-Cdh1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004789", "l": "thiamine-phosphate diphosphorylase activity", "d": ["Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H+ = diphosphate + thiamine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692539", "l": "HRH1 binds HRH1 inverse agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0050309", "l": "sugar-terminal-phosphatase activity", "d": ["Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate."], "t": []}, {"i": "EC:3.1.3.58", "l": "\"sugar-terminal-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42778", "l": "H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine => adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70911", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate = (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050296", "l": "stipitatonate decarboxylase activity", "d": ["Catalysis of the reaction: H2O + stipitatonate = CO2 + H+ + stipitatate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20197", "l": "[heparosan-N-sulfate](n) = [heparan-N-sulfate](n)", "d": [], "t": []}, {"i": "EC:5.1.3.17", "l": "\"heparosan-N-sulfate-glucuronate 5-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61102", "l": "(2S)-dihydrotricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389354", "l": "Activation of Vav1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102781", "l": "isofucosterol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + isofucosterol + O2 + NADPH = (22alpha)-hydroxy-isofucosterol + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198599", "l": "AKT phosphorylates MDM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23131", "l": "4-hydroxybutanoate + ATP + CoA <=> 4-hydroxybutanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482772", "l": "Release of platelet cytosolic components (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27674", "l": "ATP + dADP = ADP + dATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47826", "l": "3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + octadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374909", "l": "Catabolism of Noradrenaline (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917987", "l": "TFRC dimer binds 2xholoTF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11714", "l": "2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32673", "l": "ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate => ATP + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399930", "l": "Activation of PAK by Rac1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444202", "l": "Receptor FFAR1 binds free fatty acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20585", "l": "loganin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin", "d": [], "t": []}, {"i": "EC:1.14.19.62", "l": "\"secologanin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11214", "l": "2-formamidobenzaldehyde => indole + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69590", "l": "IMP + uridine => inosine + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68403", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-gurjunene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18647", "l": "NH4(+) + sym-homospermidine => 2 putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210881", "l": "Dimerization of Tie2/Ang1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432164", "l": "Ca2+ influx into the post-synaptic cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937814", "l": "RUNX3 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15757", "l": "L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52824", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 = (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0140135", "l": "mechanosensitive monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens in response to a mechanical stress."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68434", "l": "(3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal => lutein + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004024", "l": "alcohol dehydrogenase (NAD+) activity, zinc-dependent", "d": ["Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc."], "t": []}, {"i": "REACT:R-HSA-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050549", "l": "cyclohexyl-isocyanide hydratase activity", "d": ["Catalysis of the reaction: N-cyclohexylformamide + H+ = cyclohexyl isocyanide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989778", "l": "Expression of ACSL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507870", "l": "Aquaporins passively transport water out of cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416725", "l": "SEMA6D binds to PLXNA1:TREM2:DAP12 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52264", "l": "3-(aminomethyl)indole + 2 S-adenosyl-L-methionine = gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.340", "l": "\"3-aminomethylindole N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928604", "l": "SFKs phosphorylate VAV2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71825", "l": "3,3'-diiodo-L-thyronine(in) => 3,3'-diiodo-L-thyronine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021944", "l": "MECP2 binds RBFOX1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13707", "l": "alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + H(+) + UDP => alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675417", "l": "PEBP1 binds activated RAF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54106", "l": "H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28077", "l": "(2R)-3-sulfopropanediol + H2O + 2 NAD(+) <=> (2R)-3-sulfolactate + 3 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65972", "l": "a peptide antigen(in) + ATP + H2O = a peptide antigen(out) + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.4.2.14", "l": "\"ABC-type antigen peptide transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961920", "l": "E2F1 binds the CDK1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78343", "l": "5'-pGpA(2'-5') + H2O = 5'-GpA(2'-5') + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77309", "l": "5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine => N(omega),N('omega)-dimethyl-L-arginine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29904", "l": "ATP + D-ribose(out) + H2O => ADP + D-ribose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45452", "l": "H2O + N-tetradecanoylethanolamine = ethanolamine + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623168", "l": "FOXO1,FOXO1:PPARGC1A,FOXO3,FOXO4,FOXO6 bind G6PC gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693783", "l": "NAALADases hydrolyse NAAG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74312", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62567", "l": "(4S)-limonene + A + H2O <=> (4S)-perillyl alcohol + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48804", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59747", "l": "(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45427", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78767", "l": "3''-dehydroorientin = 1,5-anhydro-D-erythro-hex-1-en-3-ulose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71670", "l": "PKM dephosphorylates PEP to PYR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74986", "l": "Elongation of pre-rRNA transcript (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69999", "l": "L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64010", "l": "CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44551", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39726", "l": "a 1,2-diacyl-sn-glycerol(in) <=> a 1,2-diacyl-sn-glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29952", "l": "H(+)(in) + uridine(in) => H(+)(out) + uridine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416562", "l": "p190RhoGAP binds Plexin-B1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65420", "l": "GMP(in) + NAD(+)(out) = GMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42231", "l": "17beta-estradiol + A <=> AH2 + estrone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692408", "l": "NPR2 binds NPPC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618093", "l": "ATP hydrolysis by HSP90 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41280", "l": "H2O + N-octadecanoylsphing-4-enine => octadecanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16041", "l": "[(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72671", "l": "eIF5B:GTP is hydrolyzed and released (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033736", "l": "L-lysine 6-oxidase activity", "d": ["Catalysis of the reaction: L-lysine + H2O + O2 = allysine + H2O2 + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56013", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736966", "l": "SMAD7 binds SERPINE1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50992", "l": "thromboxane B2(out) = thromboxane B2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-706479", "l": "TAK1 is activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66986", "l": "3-methylbutanoate + CoA + H(+) => 3-methylbutanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247836", "l": "Retromer recycles WLS to the Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139842", "l": "Binding of Syk tyrosine kinase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33203", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21428", "l": "(2R)-3-sulfolactate = H(+) + pyruvate + sulfite", "d": [], "t": []}, {"i": "EC:4.4.1.24", "l": "\"(2R)-sulfolactate sulfo-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849094", "l": "ARHGAP35 binds RASA1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.36", "l": "\"hyaluronoglucuronidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30385", "l": "(-)-7-epi-alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61686", "l": "glycerol + H(+) + phosphocholine => glycero-2-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944216", "l": "Association of procollagen type XV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36456", "l": "ATP + H2O + L-alanylglycine(out) => ADP + H(+) + L-alanylglycine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018700", "l": "2-chloro-N-isopropylacetanilide reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710254", "l": "GSDME oligomerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77257", "l": "beta-D-glucosylceramide(out) => beta-D-glucosylceramide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004534", "l": "5'-3' RNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49786", "l": "CoA + H(+) + taurochenodeoxycholate => chenodeoxycholoyl-CoA + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21449", "l": "16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] => 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51914", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29902", "l": "ATP + D-xylose(out) + H2O <=> ADP + D-xylose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74102", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) <=> ADP + H(+) + L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461982", "l": "Alpha-defensin dimers multimerize to form a pore complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47662", "l": "CoA + H(+) + N-acetyl-L-methionine sulfoximine => acetyl-CoA + L-methionine sulfoximine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38651", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466706", "l": "Defective OPN1MW causes DCB and BCM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39914", "l": "(2S,3S)-3-methylphenylalanine + 2-oxoglutarate <=> (3S)-2-oxo-3-phenylbutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64448", "l": "L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.370", "l": "\"[histone H3]-lysine(4) N-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25744", "l": "H(+) + N,N-dihydroxy-L-pentahomomethionine => (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73718", "l": "UBF-1 Binds rDNA Promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114256", "l": "CYCS:APAF1 binds procaspase-9 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626928", "l": "CREBBP binds FOXO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54381", "l": "(2E,6E)-farnesyl diphosphate + H2O => 5-hydroxy-alpha-gurjunene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448948", "l": "Phosphorylation of E proteins by p38 MAPK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37324", "l": "glycyl-L-methionine + H2O => glycine + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698007", "l": "FLT3 ITD mutants bind STAT5 through GAB2:PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391158", "l": "SIRP alpha binds CD47 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611851", "l": "ADRB2 bind ADR,NAd (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109702", "l": "PDPK1 phosphorylates AKT2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71984", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + fusoxypene B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19562", "l": "androst-4-ene-3,17-dione + H(+) + NADPH + O2 => H2O + NADP(+) + testololactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63510", "l": "a (2R)-2-hydroperoxy fatty acid => a 1,2-saturated fatty acid + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45167", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73325", "l": "cimicifugate D + CoA => (2R,3S)-piscidate + (E)-caffeoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30991", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050450", "l": "citrate (Re)-synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26473", "l": "(E)-feruloyl-CoA + 16-hydroxyhexadecanoate <=> 16-feruloyloxyhexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849857", "l": "KLK5 cleaves and activates CELA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102643", "l": "scalarane-17alpha-19-diol synthase activity", "d": ["Catalysis of the reaction: scalarane-17alpha-19-diol = all-trans-geranylfarnesol + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71370", "l": "epiandrosterone 3-sulfate(out) + 2 Na(+)(out) <=> epiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836769", "l": "RSV dsRNA binds DDX58 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40592", "l": "decanedioyl-CoA + H2O => CoA + decanedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000327", "l": "PLK1 phosphorylates BORA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40332", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73214", "l": "H(+)(in) + sucrose(out) <=> H(+)(out) + sucrose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44302", "l": "4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32437", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => dihydrocarvone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044606", "l": "phosphocholine hydrolase activity", "d": ["Catalysis of the reaction: protein-serine-choline phosphate + H2O = protein-serine + choline phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15298", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45086", "l": "7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56877", "l": "(R)-N-acetyl-1-phenylethylamine + H2O => (R)-1-phenylethylamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25362", "l": "(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] <=> biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62741", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) => 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24212", "l": "5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.50", "l": "\"hydroxyethylthiazole kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202709", "l": "JAM2 dimerises (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676257", "l": "Formation of the SET1A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34877", "l": "3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH => 2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15104", "l": "H(+) + meso-2,6-diaminoheptanedioate <=> CO2 + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42444", "l": "L-aspartate + NADP(+) = H(+) + iminosuccinate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76067", "l": "an (S)-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-methionine = an (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429449", "l": "Syk activation leads to SLP-76 activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38941", "l": "diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose => dioscin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41321", "l": "1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15693", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 = (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19464", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP <=> 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51209", "l": "20-hydroxy-leukotriene B4 + NADP(+) => 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58970", "l": "1-naphthoate + H(+) + H2O2 => 1-naphthaldehyde + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019874", "l": "6-aminohexanoate-cyclic-dimer hydrolase activity", "d": ["Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65505", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618331", "l": "HDAC6 deacetylates microtubules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71887", "l": "GTP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51556", "l": "(S)-glaucine + S-adenosyl-L-methionine = (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21382", "l": "AMP + diphosphate + phytanoyl-CoA => 3,7,11,15-tetramethylhexadecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53942", "l": "18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74180", "l": "a secondary alkyl amine + H2O + NADP(+) => a ketone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0035091", "l": "phosphatidylinositol binding", "d": ["Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67708", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30183", "l": "L-galactonate + NAD(+) = H(+) + keto-D-tagaturonate + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.414", "l": "\"L-galactonate 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.17", "l": "\"stromelysin 1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811412", "l": "Active ARF recruits coatomer to the Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51252", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9824897", "l": "p-S-TBK1 phosphorylates OPTN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42088", "l": "all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49211", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56381", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 => (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990827", "l": "deaminase binding", "d": ["Binding to an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392513", "l": "Rap1 signal termination by Rap1GAPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15274", "l": "2-oxoglutarate + L-dopa => 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28235", "l": "L-glutamate 5-semialdehyde => (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801101", "l": "RABGGTA binds RABGGTB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27659", "l": "2-deoxy-alpha-D-ribose 1-phosphate => 2-deoxy-D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73732", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate => (2S,3R,11S)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50854", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30846", "l": "H2O + N-formylmaleamate <=> formate + H(+) + maleamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68603", "l": "ORC5 binds ORC2:ORC3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66813", "l": "5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH => 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114552", "l": "Thrombin-activated PARs activate G12/13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016362", "l": "activin receptor activity, type II", "d": ["Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor."], "t": []}, {"i": "REACT:R-HSA-201443", "l": "Type II receptor phosphorylates type I receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27629", "l": "D-erythrose 4-phosphate + D-xylulose 5-phosphate <=> beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75412", "l": "demethyllactenocin + S-adenosyl-L-methionine => H(+) + lactenocin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63754", "l": "carminate + 2 H(+) + UDP => kermesate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684016", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080098", "l": "L-tyrosine:pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: L-tyrosine + pyruvate = (4-hydroxyphenyl)pyruvate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012036", "l": "ME1 tetramer decarboxylates MAL to PYR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14149", "l": "luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.190", "l": "\"luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72608", "l": "(E)-sinapoyl-AMP + CoA => (E)-sinapoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68936", "l": "ATP + H(+) + NADPH + nonanoate = AMP + diphosphate + NADP(+) + nonanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336443", "l": "LIN7, CASK and APBA1 bind (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603467", "l": "Activated protein C is released from PROCR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37109", "l": "N(7)-methylguanosine + phosphate => H2O + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252072", "l": "AZGP1 binds PIP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050198", "l": "pinosylvin synthase activity", "d": ["Catalysis of the reaction: trans-cinnamoyl-CoA + 3 H+ + 3 malonyl-CoA = 4 CO2 + 4 CoA + pinosylvin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162194", "l": "COQ7:COQ9 octamer hydroxylates DMQ10H2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33124", "l": "all-trans-heptaprenyl diphosphate => (R)-tetraprenyl-beta-curcumene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592240", "l": "Formation of NRF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75430", "l": "eburicol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25837", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O => 5-deoxy-D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938356", "l": "RMB14 binds RUNX2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038121", "l": "C-C motif chemokine 21 receptor activity", "d": ["Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67812", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.53", "l": "\"[myosin-light-chain] phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35401", "l": "beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+) => 1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102286", "l": "ornithine N-delta-acetyltransferase activity", "d": ["Catalysis of the reaction: L-ornithinium(1+) = N(5)-acetyl-L-ornithine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78787", "l": "apigenin + UDP-alpha-D-glucose = H(+) + isovitexin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29462", "l": "beta-alanine(in) + H(+)(in) <=> beta-alanine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848339", "l": "PNPLA5 hydrolyzes TAG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67711", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48528", "l": "a ganglioside GP1c (d18:1(4E)) + H2O = a ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216040", "l": "Collagen type IV networks bind integrins alpha1beta1, alpha2beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181156", "l": "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57569", "l": "7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692738", "l": "HRH2 binds HRH2 antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690494", "l": "RHOB translocates to the endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43993", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 => 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41696", "l": "1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73397", "l": "L-aspartate(out) + sulfate(in) => L-aspartate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047973", "l": "guanidinoacetate kinase activity", "d": ["Catalysis of the reaction: ATP + guanidinoacetate = ADP + 2 H+ + phosphoguanidinoacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106368", "l": "(deoxy)nucleoside phosphate kinase activity, dTTP as phosphate donor", "d": ["Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP."], "t": []}, {"i": "RHEA:62132", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052620", "l": "thymine dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + thymine + acceptor = 5-methyl-barbiturate + donor-H2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50785", "l": "dodecanal + NADP(+) => (2E)-dodecenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046175", "l": "Further sulfation on galactose residues produces KSPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69743", "l": "(S)-2-benzylsuccinate + succinyl-CoA = (S)-2-benzylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62343", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) <=> (+)-malbrancheamide C + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11555", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H2O <=> 1-O-alkyl-sn-glycerol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.45", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77347", "l": "L-alanine + oxaloacetate = L-aspartate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381217", "l": "IRE1:BiP dissociates in response to unfolded protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41337", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.40", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61486", "l": "a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59193", "l": "ATP + eicosanoate + H(+) => diphosphate + icosanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37865", "l": "1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.363", "l": "\"ginsenoside 20-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.23", "l": "\"lipopolysaccharide heptosyltransferase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013143", "l": "RAC1 GEFs activate RAC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047163", "l": "3,4-dichloroaniline N-malonyltransferase activity", "d": ["Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonamate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69350", "l": "(E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate => S-1-propenyl-L-cysteine sulfoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67409", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37467", "l": "1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62477", "l": "3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209109", "l": "Further phosphorylation of ARM by SGG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428750", "l": "Gq activation by TP receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66946", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042901", "l": "arabinan transmembrane transporter activity", "d": ["Enables the transfer of an arabinan, a polysaccharide composed of arabinose residues, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11894", "l": "H(+) + nororientaline + S-adenosyl-L-homocysteine => 6-O-methylnorlaudanosoline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852019", "l": "MET bound PI3K generates PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.218", "l": "\"phenylpropanoylacetyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22934", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226014", "l": "Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678925", "l": "NR3C1 binds NR3C1 agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78167", "l": "2-epi-5-epi-valiolone + NAD(+) = demethylgadusol + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.126", "l": "\"2-epi-5-epi-valiolone dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428752", "l": "Dissociation of the TP:Gq complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49963", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 <=> 5,10-dihydrophenazine + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12074", "l": "a (2S)-2-hydroxycarboxylate + a halide anion + H(+) => an (S)-2-haloacid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879910", "l": "JAK2 is phosphorylated, activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632677", "l": "PTCH is internalized (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35600", "l": "NADP(+) + propane-1,3-diol => 3-hydroxypropanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050536", "l": "(S)-N-acetyl-1-phenylethylamine hydrolase activity", "d": ["Catalysis of the reaction: N-acetylphenylethylamine + H2O = acetate + phenylethylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047205", "l": "quinate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3785711", "l": "Telomere shortening during replicative exhaustion (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731018", "l": "SARS-CoV-1 M binds to PDPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189488", "l": "UROS transforms HMB to URO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64649", "l": "(E)-coniferaldehyde + CoA + NADP(+) => (E)-feruloyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10757", "l": "ATP + phosphate + pyruvate => AMP + diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18938", "l": "an N-acyl-L-homoserine lactone + H2O => a carboxylate + L-homoserine lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76903", "l": "(1S)-2-methyl-cyclohexylamine + H2O + NAD(+) = 2-methylcyclohexanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140383", "l": "4-hydroxytryptamine kinase activity", "d": ["Catalysis of the reaction: 4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867344", "l": "OMA1 hydrolyses OPA1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59230", "l": "6-sulfo-beta-D-quinovose => 6-sulfo-alpha-D-quinovose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75871", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}, {"i": "EC:2.1.1.385", "l": "\"[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]--tetrahydrofolate methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13758", "l": "(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose => (Z)-desulfoglucotropeolin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004059", "l": "aralkylamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50787", "l": "dodecanal + NADP(+) <=> (2E)-dodecenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014296", "l": "RAC2 GEFs activate RAC2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050333", "l": "thiamine triphosphate phosphatase activity", "d": ["Catalysis of the reaction: H2O + thiamine triphosphate = thiamine diphosphate + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46661", "l": "H(+) + NADPH + progesterone => 5beta-pregnan-3,20-dione + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60210", "l": "3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate => 3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984671", "l": "Chromokinesins form dimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67602", "l": "diphosphate + H(+) + O(6)-methyl-dGMP => H2O + O(6)-methyl-dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31021", "l": "4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O => 4 AH2 + all-trans-4,4'-diapolycopene + 4 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016210", "l": "naringenin-chalcone synthase activity", "d": ["Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38962", "l": "a 2,3-saturated acyl-CoA + O2 <=> a (2E)-enoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10354", "l": "acetate + an aralkylamine => an N-acetylarylalkylamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102910", "l": "dirigent protein activity", "d": ["Catalysis of the reaction: 2 H+ + 2 coniferol + O2 = (+)-pinoresinol + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854981", "l": "SHC1 in the RET complex is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56748", "l": "an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26180", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate", "d": [], "t": []}, {"i": "EC:3.5.1.103", "l": "\"N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391941", "l": "BLT receptors can bind LTB4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51429", "l": "acetyl-CoA + aminomethylphosphonate => 2-N-acetamidomethylphosphonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33029", "l": "3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one => 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828023", "l": "Expression of POU5F1 (OCT4) in primordial germ cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57658", "l": "a ganglioside GT1balpha + CMP + H(+) => a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29242", "l": "H(+)(in) + uracil(in) <=> H(+)(out) + uracil(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22226", "l": "1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O => 3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43018", "l": "2-aminoprop-2-enoate + an alkyl thiol => an S-alkyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23788", "l": "acetate + ATP + holo-[citrate lyase ACP] = acetyl-[citrate lyase ACP] + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.22", "l": "\"[citrate (pro-3S)-lyase] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018808", "l": "RAC3 binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021609", "l": "ESR-associated SRC autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047781", "l": "citrullinase activity", "d": ["Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12664", "l": "(R)-carnitine + hexadecanoyl-CoA <=> CoA + O-hexadecanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699574", "l": "FOXO3-dependent BCL2L11 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62028", "l": "H2O + stigmasteryl 3-beta-D-glucoside = D-glucose + stigmasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507871", "l": "Aquaporins passively transport glycerol out of cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41848", "l": "(2E)-octenoyl-[ACP] + H(+) + NADPH = NADP(+) + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54972", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0016168", "l": "chlorophyll binding", "d": ["Binding to a chlorophyll; a compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70571", "l": "D-glucose(out) + Na(+)(out) = D-glucose(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64126", "l": "hexadecanoate + L-phenylalanine => H2O + N-hexadecanoyl-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66108", "l": "2-oxobutanoate + L-cysteine = (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33185", "l": "citrate(out) => citrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62540", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain = dihydroouabain + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43193", "l": "cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine => 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694428", "l": "LMAN family proteins bind glycosylated cargo (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28554", "l": "D-mannose 6-phosphate + H2O = D-mannose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63379", "l": "an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77901", "l": "(1-deoxy-D-fructos-1-yl)amine + 6-oxohexanoate + H2O2 => H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-6-aminohexanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44874", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64646", "l": "butyl propanoate + CoA => butan-1-ol + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20489", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)", "d": [], "t": []}, {"i": "EC:2.3.2.11", "l": "\"alanylphosphatidylglycerol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20559", "l": "CO2 + 2 NH4(+) => 2 H(+) + H2O + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9823816", "l": "OPTN binds CASP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16400", "l": "2 D-glucopyranose 1-phosphate <=> D-glucose + D-glucose 1,6-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60126", "l": "diphosphate + sodorifen => pre-sodorifen diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36958", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA <=> (9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1006143", "l": "CD46 binds C3b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17808", "l": "H2O + S-adenosyl-L-homocysteine <=> adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49265", "l": "5-O-[(E)-caffeoyl]-shikimate + H2O => (E)-caffeate + H(+) + shikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48340", "l": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.2", "l": "\"medium-chain acyl-CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78384", "l": "L-cysteinyl-[SCAN] + S-nitroso-CoA => CoA + S-nitroso-L-cysteinyl-[SCAN]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047037", "l": "salutaridine reductase (NADPH) activity", "d": ["Catalysis of the reaction: (7S)-salutaridinol + NADP+ = H+ + NADPH + salutaridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659755", "l": "Defective SLC6A18 does not transport Gly from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015473", "l": "fimbrial usher porin activity", "d": ["A porin that acts in the assembly of fimbria together with fimbrial chaperone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35686", "l": "hexadecasphinganine + NADP(+) <=> 3-oxohexadecasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54008", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65470", "l": "CoA + propyl acetate => 1-propanol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050331", "l": "thiamine-diphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0022848", "l": "acetylcholine-gated monoatomic cation-selective channel activity", "d": ["Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047650", "l": "alkylglycerone kinase activity", "d": ["Catalysis of the reaction: O-alkylglycerone + ATP = O-alkylglycerone phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70434", "l": "2 H(+)(out) + Li(+)(in) <=> 2 H(+)(in) + Li(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62914", "l": "1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+) => H(+) + NADH + O2 + toralactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.93", "l": "\"pyrrole-2-carboxylate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202222", "l": "Phosphorylation of PKC theta (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65413", "l": "dAMP(in) + NAD(+)(out) => dAMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.34", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55317", "l": "3 H2O + hydrogen sulfide + 3 NAD(+) => 4 H(+) + 3 NADH + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22797", "l": "ATP + D-hamamelose => ADP + D-hamamelose 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004905", "l": "type I interferon receptor activity", "d": ["Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050022", "l": "L-arabinose 1-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34929", "l": "glutathione + glutathioselenol + NADP(+) => H(+) + NADPH + selenodiglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68894", "l": "3-methoxybenzaldehyde + AMP + diphosphate + NADP(+) => 3-methoxybenzoate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797553", "l": "Protein 4.1 binds CASK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42694", "l": "[(1->4)-alpha-D-glucosyl](n+2) + phosphate => [(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42930", "l": "H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine => cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75747", "l": "10-oxooctadecanoate + H(+) + NADH = 10-hydroxyoctadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17176", "l": "glutathionylspermidine + H2O <=> glutathione + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140685", "l": "FAD-dependent histone H3K9me/H3K9me2 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78128", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55333", "l": "a 3'-hydroxyflavone + S-adenosyl-L-methionine => a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32565", "l": "alpha-terpinene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15554", "l": "1D-myo-inositol 1,4-bisphosphate + H2O => 1D-myo-inositol 4-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159771", "l": "Furin cleaves pro-protein C to protein C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66836", "l": "4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase] = asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9733973", "l": "Bile salts bind FABP6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12298", "l": "dopamine + secologanin => H2O + N-deacetylipecoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29778", "l": "alpha-D-ribose 1-phosphate + ATP <=> ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129357", "l": "Fibrillin C-terminal processing (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60408", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O = Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38588", "l": "UDP-alpha-D-glucose + vancomycin aglycone => devancoaminyl-vancomycin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112604", "l": "Phosphorylated STATs are released (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014293", "l": "RAC2 GDIs block activation of RAC2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004938", "l": "alpha2-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10332", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.62", "l": "\"2-acylglycerophosphocholine O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52480", "l": "16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421447", "l": "protoporphyrin IX + Fe++ => heme + 2 H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012349", "l": "ME3 tetramer decarboxylates MAL to PYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202966", "l": "Caspase mediated cleavage of HIP-55 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5246478", "l": "APOM binds retinoids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102413", "l": "6-O-methyl-deacetylisoipecoside beta-glucosidase activity", "d": ["Catalysis of the reaction: 6-O-methyl-N-deacetylisoipecoside + H2O = 6-O-methyl-N-deacetylisoipecoside aglycon + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70700", "l": "H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) => H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18566", "l": "19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine => 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75209", "l": "Ag(+)(in) => Ag(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68197", "l": "1,2-dihexanoylglycerol + tetradecanoyl-CoA => 1,2-dihexanoyl-3-tetradecanoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52583", "l": "ATP + H2O + Pb(2+)(in) <=> ADP + H(+) + Pb(2+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40414", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222491", "l": "Lactoferrin scavenges iron ions (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350467", "l": "GUG binds to FT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43821", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41289", "l": "sphing-4-enine + tetradecanoate => H2O + N-tetradecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26288", "l": "Co-precorrin-5B + S-adenosyl-L-methionine <=> Co-precorrin-6A + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73739", "l": "dopamine(in) + 2 H(+)(out) = dopamine(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035478", "l": "chylomicron binding", "d": ["Binding to a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37164", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047176", "l": "beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity", "d": ["Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070225", "l": "sulfide dehydrogenase activity", "d": ["Catalysis of the reaction: hydrogen sulfide + oxidized cytochrome c = S + reduced cytochrome c."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5606996", "l": "Soluble PROCR binds activated protein C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12131", "l": "2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18292", "l": "(S,S)-tartrate <=> H2O + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18507", "l": "Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+) => L-lysine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48502", "l": "glycerol + H(+) + octanoate => H2O + octanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24622", "l": "H(+) + NADH + octanal => NAD(+) + octan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37680", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19652", "l": "ATP + L-aspartate + tRNA(Asp) <=> AMP + diphosphate + L-aspartyl-tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871266", "l": "YAP1 binds TEAD3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044586", "l": "cellotetraose binding", "d": ["Binding to a cellotetraose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53520", "l": "1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17649", "l": "acetyl-[ACP] + malonate = acetate + malonyl-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.187", "l": "\"acetyl-S-ACP:malonate ACP transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990634", "l": "protein phosphatase 5 binding", "d": ["Binding to protein phosphatase 5."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661710", "l": "An unknown oxidase oxidises D-UBGN to UBN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23549", "l": "guanosine(966) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52556", "l": "3-dehydro-D-erythronate + ATP = 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166792", "l": "Conversion of C2 into C2a and C2b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74718", "l": "Internalisation of the insulin receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9865663", "l": "MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662466", "l": "XYLB phosphorylates D-xylulose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.571199156962493", "identifiers": [{"i": "GO:0004634", "l": "phosphopyruvate hydratase activity", "d": ["Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63045", "l": "H2O + mevastatin => H(+) + mevinic carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46290", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003692", "l": "left-handed Z-DNA binding", "d": ["Binding to DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19069", "l": "(R)-S-lactoylglutathione = glutathione + methylglyoxal", "d": [], "t": []}, {"i": "EC:4.4.1.5", "l": "\"lactoylglutathione lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50842", "l": "(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78668", "l": "(3R)-hydroxytetradecanoyl-CoA + NAD(+) => 3-oxotetradecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183051", "l": "CBL ubiquitinates Sprouty (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62231", "l": "(E)-ascladiol + A <=> AH2 + patulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982017", "l": "Active G alpha (q) binds RGS proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987223", "l": "IL10RB binds TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0055105", "l": "ubiquitin-protein transferase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61628", "l": "5-aminopentanal = 1-piperideine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35684", "l": "hexadecasphinganine + NADP(+) => 3-oxohexadecasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30900", "l": "bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17801", "l": "acetyl-CoA + L-phenylalanine = CoA + H(+) + N-acetyl-L-phenylalanine", "d": [], "t": []}, {"i": "EC:2.3.1.53", "l": "\"phenylalanine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74908", "l": "(2E)-but-2-enoyl-AMP + holo-[ACP] => (2E)-butenoyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72406", "l": "2-oxoglutarate(out) + urate(in) <=> 2-oxoglutarate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54632", "l": "2-oxoglutarate + O2 + tetradecanoyl-CoA = 2-hydroxytetradecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791058", "l": "Expression of Cullin-7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14227", "l": "6-oxohexanoate + H(+) + NADH => 6-hydroxyhexanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23204", "l": "chlorogenate + D-glucarate = 2-O-caffeoylglucarate + L-quinate", "d": [], "t": []}, {"i": "EC:2.3.1.98", "l": "\"chlorogenate--glucarate O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31014", "l": "(S)-2,3-epoxysqualene <=> camelliol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24603", "l": "H2O + O2 + sulfite <=> H2O2 + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33129", "l": "beta-D-glucose 6-phosphate + salicyl alcohol => H2O + salicin-6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624948", "l": "KIF17 enters the cilium (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3065958", "l": "An unknown protease degrades ACACA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399982", "l": "AKT1 E17K mutant phosphorylates TSC2, inhibiting it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26173", "l": "1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA => CoA + H(+) + mycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63016", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21124", "l": "cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805479", "l": "TP53RK phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2423785", "l": "CR:atREs binds apoE and HSPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78388", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[SCAN] => L-cysteinyl-[SCAN] + S-nitroso-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20154", "l": "ATP + L-arabinose => ADP + beta-L-arabinose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0045296", "l": "cadherin binding", "d": ["Binding to cadherin, a type I membrane protein involved in cell adhesion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45327", "l": "H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55647", "l": "ATP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] <=> ADP + C-terminal S-cyanate-L-cysteinyl-[HypE protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16676", "l": "3-phosphonopyruvate + H2O <=> H(+) + phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35756", "l": "NAD(+) + UDP-alpha-D-glucose => H(+) + NADH + UDP-3-oxo-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844617", "l": "IPAF binds procaspase-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16996", "l": "6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] <=> 6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731931", "l": "EDNRA binds selective ERAs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614933", "l": "ACEIs bind ACE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835189", "l": "NCK1 binds PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000121", "l": "glycerol-1-phosphatase activity", "d": ["Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12568", "l": "4-nitrophenol + H(+) + NADH + O2 = 4-nitrocatechol + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.29", "l": "\"4-nitrophenol 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2990882", "l": "CDK1 phosphorylates NUP98 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75079", "l": "Formation of AT-AC C complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114553", "l": "Activation of conventional Protein Kinase C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61295", "l": "(R)-pantoate + NAD(+) <=> 2-dehydropantoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29076", "l": "formate(out) + 2 H(+)(in) + ubiquinone-8 => CO2(out) + H(+)(out) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29038", "l": "ATP + H2O + L-glutamate(out) <=> ADP + H(+) + L-glutamate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36545", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate => H2O + mycothiol S-conjugate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57501", "l": "3-hydroxybutane-1,2,3-tricarboxylate => 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5246478", "l": "APOM binds retinoids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31949", "l": "ent-isokauren-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-isokaurene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811508", "l": "ING2-bound EP300 acetylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5615668", "l": "AKR1C3 reduces atRAL to atROL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1364044", "l": "PRLR:JAK2 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77096", "l": "5-S-cysteinyldopa + L-dopaquinone => 5-S-cysteinyldopaquinone + L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5615668", "l": "AKR1C3 reduces atRAL to atROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30883", "l": "D-glucurono-3,6-lactone + 2 H2O + NAD(+) = D-glucarate + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015233", "l": "pantothenate transmembrane transporter activity", "d": ["Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22278", "l": "a 2-oxocarboxylate + 2 H(+) + NADH => 2-oxoaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803890", "l": "SFN dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55251", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033716", "l": "nucleoside oxidase (hydrogen peroxide-forming) activity", "d": ["Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604368", "l": "Autocatalytic activation of bound proMMP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622737", "l": "FOXO3,FOXO6,(FOXO1) binds CAT gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41016", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol => 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19119", "l": "(R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical => dopamine + 2 L-ascorbate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851979", "l": "BTNL9 binds immune cell surfaces (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44810", "l": "2-demethylmenaquinol-10 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9865663", "l": "MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047151", "l": "tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH + H+ = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28826", "l": "H(+)(in) + L-galactonate(in) <=> H(+)(out) + L-galactonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607740", "l": "PKC-delta phosphorylates CARD9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56134", "l": "a thymidine dimer in DNA => (5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034236", "l": "protein kinase A catalytic subunit binding", "d": ["Binding to one or both of the catalytic subunits of protein kinase A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654510", "l": "FGFRL1 binds SPRED1/2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61741", "l": "steviolmonoside + UDP-alpha-D-glucose => H(+) + steviolbioside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23381", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16758", "l": "NADP(+) + trypanothione => H(+) + NADPH + trypanothione disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.35", "l": "\"hyaluronoglucosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374665", "l": "DCC interaction with SIAH1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430347", "l": "MigFilin associates with Filamin and F-actin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.39", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14014", "l": "3'-phosphoadenylyl sulfate + taurolithocholate => adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571327", "l": "IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34682", "l": "ATP + methylphosphonate <=> adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43984", "l": "(2E,6E)-farnesol + H(+) + NADPH + O2 = (2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18890", "l": "D-glucose 6-phosphate + UDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74740", "l": "Binding of SHC1 to insulin receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12920", "l": "3alpha(S)-strictosidine + H2O <=> D-glucose + strictosidine aglycone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0030371", "l": "translation repressor activity", "d": ["Antagonizes ribosome-mediated translation of mRNA into a polypeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59293", "l": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O => D-galactose + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21632", "l": "2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O", "d": [], "t": []}, {"i": "EC:1.10.3.1", "l": "\"catechol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176175", "l": "Stalling of DNA replication fork and RPA binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001001", "l": "mitochondrial single-subunit type RNA polymerase binding", "d": ["Binding to a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59571", "l": "4-aminobutanoate + ATP + L-histidine <=> ADP + H(+) + L-homocarnosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20062", "l": "2'-deoxycytidine + a ribonucleoside 5'-triphosphate => a ribonucleoside 5'-diphosphate + dCMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48329", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose => a III(4)-a-Fuc-Lc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57335", "l": "H2O + 3 O2 + 3 propionate 3-nitronate <=> 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497883", "l": "Ferrous iron reduces the BH3 radical back to BH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22804", "l": "(6S,9R)-vomifoliol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.221", "l": "\"vomifoliol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20983", "l": "2 (4Z,15Z)-bilirubin IXalpha + O2 <=> 2 biliverdin IXalpha + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10321", "l": "trans-3-hydroxy-L-proline => 1-pyrroline-2-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008979", "l": "prophage integrase activity", "d": ["Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome, via a sequence-specific recombination event which involves the formation of an intasome, a DNA-protein-complex designed for site-specific recombination of the phage and host DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9649733", "l": "mature p21 RAS binds GDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250930", "l": "B-WICH recruits histone acetyltransferases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29984", "l": "cytidine(in) + H(+)(in) => cytidine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15434", "l": "(2S)-naringenin + dimethylallyl diphosphate => diphosphate + sophoraflavanone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112510", "l": "IL6ST is tyrosine phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14155", "l": "17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP => 17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39915", "l": "1-O-alkyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048487", "l": "beta-tubulin binding", "d": ["Binding to the microtubule constituent protein beta-tubulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28140", "l": "streptothricin F acid => H2O + streptothricin F", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47941", "l": "a ganglioside GM2 (d18:1(4E)) + H2O => a ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167419", "l": "The receptor:G-protein complex releases GDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78897", "l": "a very-long-chain 3-oxoacyl-CoA + CoA => a very long-chain fatty acyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67000", "l": "2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + phlorisobutanophenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49744", "l": "deoxyviolaceinate + H(+) + O2 = CO2 + deoxyviolacein + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71749", "l": "2-oxoglutarate(in) + L-2-aminoadipate(out) => 2-oxoglutarate(out) + L-2-aminoadipate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54759", "l": "deamido-NAD(+) + hydrogencarbonate <=> AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59393", "l": "acetyl-CoA + L-seryl-[protein] => CoA + O-acetyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40993", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA => (E)-4-coumaroyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106439", "l": "L-lysine:L-arginine antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)."], "t": []}, {"i": "RHEA:70827", "l": "L-arginine(in) + L-lysine(out) = L-arginine(out) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0001221", "l": "transcription coregulator binding", "d": ["Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25119", "l": "(S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+) => H2O + L-lysine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65226", "l": "H(+) + NADPH + naphthalene-1,2-diol => (1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483087", "l": "PI is exchanged with PC by PITPNB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77620", "l": "2 a 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) => a 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008834", "l": "di-trans,poly-cis-undecaprenyl-diphosphate synthase activity", "d": ["Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55870", "l": "H2O2 + pyruvate => (S)-lactate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23378", "l": "3-dehydro-D-erythronate + H(+) + NADH => L-threonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42720", "l": "S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.166", "l": "\"23S rRNA (uridine(2552)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15886", "l": "NADP(+) + propane-1,2-diol => (S)-lactaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31496", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76374", "l": "n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) <=> n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17227", "l": "6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23624", "l": "a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9676254", "l": "Formation of the MLL3 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050206", "l": "oximinotransferase activity", "d": ["Catalysis of the reaction: 2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62346", "l": "diphosphate + notoamide S => 6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65063", "l": "NADP(+) + taurochenodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78353", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phospho-L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252072", "l": "AZGP1 binds PIP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983142", "l": "Formation of peptide loading complex (PLC) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0008252", "l": "nucleotidase activity", "d": ["Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate."], "t": []}, {"i": "RHEA:22140", "l": "a nucleoside 5'-phosphate + H2O = a nucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008871", "l": "aminoglycoside 2''-nucleotidyltransferase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.253", "l": "\"baicalein 7-O-glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26130", "l": "diphosphate + isopimara-7,15-diene => (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944225", "l": "Association of procollagen type XVII (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57913", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) => H(+) + L-glutaminyl-tRNA(Gln) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661217", "l": "MT1A binds zinc (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62314", "l": "H(+) + salicylate 2-O-beta-D-glucoside + UDP => salicylate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16779", "l": "ADP + H(+) + K(+)(in) + phosphate => ATP + H2O + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000403", "l": "Y-form DNA binding", "d": ["Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33994", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-copaene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6813740", "l": "GDE1 hydrolyzes GroPIns (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372697", "l": "Crk binding to p130cas (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446694", "l": "IRAK4 phosphorylates IRAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647631", "l": "GSDMD (1-275) binds PIPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199587", "l": "KIR2DS1 interacting with HLA-C group 2 (Cw4) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102459", "l": "8-oxo-dADP diphosphate phosphatase activity", "d": ["Catalysis of the reaction: 8-oxo-dADP + H2O = 8-oxo-dAMP + hydrogenphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64224", "l": "AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0141147", "l": "intracellularly calcium-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens when calcium ions bind on the intracellular side of the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047653", "l": "allantoin racemase activity", "d": ["Catalysis of the reaction: (S)-(+)-allantoin = (R)-(-)-allantoin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-996755", "l": "ZFPM proteins bind GATA proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102840", "l": "1-18:2-2-16:3-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:3-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159868", "l": "Furin cleaves pro-factor VII to factor VII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20674", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48207", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA <=> (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160097", "l": "reverse gyrase activity", "d": ["Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle, is driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54721", "l": "N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17460", "l": "[sulfur-carrier protein]-L-cysteine + L-cysteine <=> [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254291", "l": "ERBB4s80 binds STAT5A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944215", "l": "Association of procollagen type XX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250280", "l": "ROS oxidize thioredoxin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450971", "l": "NNT dimer transfers proton from NADPH to NAD+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701485", "l": "Active ALK binds JAK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9866253", "l": "apo-UQCRFS1 binds LYRM7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382054", "l": "PDGF binds to extracellular matrix proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15235", "l": "Fe(II)-[cytochrome c] + 2 H(+) + nitrite => Fe(III)-[cytochrome c] + H2O + nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23232", "l": "4 Fe(III)-[cytochrome c] + hydrazine = 4 Fe(II)-[cytochrome c] + 4 H(+) + N2", "d": [], "t": []}, {"i": "EC:1.7.2.8", "l": "\"hydrazine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34689", "l": "A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine => AH2 + N-acyl-15-methylhexadecasphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42128", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72990", "l": "myo-inositol(out) + 2 Na(+)(out) <=> myo-inositol(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357483", "l": "RAC1 binds PAK1-3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58410", "l": "H(+) + NADPH + undecanal => NADP(+) + undecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399939", "l": "Autophosphorylation of PAK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78266", "l": "9-cis-retinol + a fatty acyl-CoA <=> 9-cis-retinyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55185", "l": "2-oxoglutarate + 3-methylundecanoyl-CoA + O2 => 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.8", "l": "\"muramoylpentapeptide carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41571", "l": "aclacinomycin T + dTDP-2-deoxy-beta-L-fucose <=> aclacinomycin S + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46673", "l": "aldosterone + H(+) + NADPH => 5beta-dihydroaldosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22074", "l": "ADP + H(+) + L-ribulose 5-phosphate => ATP + L-ribulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11497", "l": "O-acetyl-L-serine + uracil => 3-(uracil-1-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9613497", "l": "Unwinding DNA for the nascent transcript (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797961", "l": "CHDH oxidises Cho to BETALD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187575", "l": "Ubiquitination of phospho-p27/p21 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647980", "l": "mature RAS proteins translocate to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.3", "l": "\"hydrogen dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38411", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15363", "l": "a dolichyl D-xylosyl phosphate + UDP => a dolichyl phosphate + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008656", "l": "cysteine-type endopeptidase activator activity involved in apoptotic process", "d": ["Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43050", "l": "keto-D-sorbose => keto-D-tagatose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3238691", "l": "N-linked glycosylation of WNTs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195739", "l": "Palmitoylation of cysteine residues on M2 in the cis-golgi network (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56607", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23890", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate => [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65829", "l": "H2O + neryl diphosphate => diphosphate + nerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0106345", "l": "glyoxylate reductase activity", "d": ["Catalysis of the reaction: glycolate + NAD(P)+ = glyoxylate + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050656", "l": "3'-phosphoadenosine 5'-phosphosulfate binding", "d": ["Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40849", "l": "(2E)-eicosenoyl-CoA + FADH2 => eicosanoyl-CoA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707594", "l": "Hemes bind LY96 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209245", "l": "Tyrosine kinase Hopscotch (HOP) binds to the transmembrane cytokine receptor Domeless (DOME) to form the HOP:DOME complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "58.671674362540081", "identifiers": [{"i": "GO:0003676", "l": "nucleic acid binding", "d": ["Binding to a nucleic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37497", "l": "1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102180", "l": "4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 + H+ = 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17788", "l": "H(+) + L-glutamate <=> 4-aminobutanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047855", "l": "dihydrobunolol dehydrogenase activity", "d": ["Catalysis of the reaction: dihydrobunolol + NADP+ = bunolol + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33120", "l": "(2E,6E)-farnesyl diphosphate => (+)-sativene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60172", "l": "5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate = (2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10696", "l": "a long-chain fatty acid + ATP + holo-[mycocerosate synthase] = AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]", "d": [], "t": []}, {"i": "EC:6.2.1.49", "l": "\"long-chain fatty acid adenylyltransferase FadD28\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130151", "l": "Dimerization of DAP12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18416", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669240", "l": "FLNA binds PAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663155", "l": "p-BMAL1:p-CLOCK,NPAS2 binds NR1D1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53764", "l": "allocholate + lithocholoyl-CoA = allocholoyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28611", "l": "H2O + XTP => diphosphate + H(+) + XMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174124", "l": "Dephosphorylation of phospho-Cdh1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451311", "l": "Activation of Ca-permeable Kainate receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021050", "l": "HSBP1 oligomer binds ESRs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27336", "l": "6-hydroxynicotinate + 2 H(+) + NADH + O2 <=> 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23604", "l": "kievitone hydrate = H2O + kievitone", "d": [], "t": []}, {"i": "EC:4.2.1.95", "l": "\"kievitone hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061797", "l": "pH-gated chloride channel activity", "d": ["A gated channel activity that enables the transmembrane transfer of a chloride ion by a channel that opens in response to a change in pH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71493", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out) => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034602", "l": "oxoglutarate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41010", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin <=> 6-linalyl-2-O,3-dimethylflaviolin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65703", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209840", "l": "Two DITs combine to form thyroxine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45546", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76765", "l": "1,4-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64540", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": [], "t": []}, {"i": "EC:2.7.1.228", "l": "\"mannosyl-inositol-phosphoceramide inositolphosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43320", "l": "1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24102", "l": "diisopropyl phosphate + fluoride + 2 H(+) => diisopropyl fluorophosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73937", "l": "desmethyl-dehydrogriseofulvin + 2 H2O + oxidized [NADPH--hemoprotein reductase] => griseophenone B + H(+) + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389756", "l": "AKT interacts and phosphorylates Cot (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672162", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805546", "l": "Keratin type I binds keratin type II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0031559", "l": "oxidosqualene cyclase activity", "d": ["Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40466", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042293", "l": "Hub1 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373342", "l": "CX3CR1 binds CX3CL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804527", "l": "INTL1 binds bacterial glycans (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64366", "l": "(15S)-15-hydroperoxy-prostaglandin E2 => prostaglandin G2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021068", "l": "PalmS-ESRs bind CAVs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46415", "l": "a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.045601261176557", "identifiers": [{"i": "GO:0015932", "l": "nucleobase-containing compound transmembrane transporter activity", "d": ["Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41229", "l": "4-hydroxyphenylglyoxylate + H2O2 => (S)-4-hydroxymandelate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170978", "l": "p-FRS2:CRKL binds C3G (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404134", "l": "RBP4:atROL binds TTR (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27899", "l": "3'-AMP + H2O => adenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68330", "l": "(R)-pantetheine + phosphate => (R)-4'-phosphopantetheine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25706", "l": "H(+) + N,N-dihydroxy-L-dihomomethionine = (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52400", "l": "4-O-phospho-D-threonate + NAD(+) = 3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.73", "l": "\"jararhagin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45776", "l": "(indol-3-yl)acetonitrile + 2 H2O = (indol-3-yl)acetate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47788", "l": "a cytidine in 28S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36334", "l": "ATP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373042", "l": "2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15986", "l": "formate + NAD(+) => CO2 + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428750", "l": "Gq activation by TP receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23677", "l": "ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.10", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668404", "l": "TNFA binds TNFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791137", "l": "Expression of Talin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71164", "l": "HGD dioxygenates homogentisate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10343", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-vetispiradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77259", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15478", "l": "3'-phosphoadenylyl sulfate + 5beta-scymnol => 5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17177", "l": "(R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine", "d": [], "t": []}, {"i": "EC:2.3.1.137", "l": "\"carnitine O-octanoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0071791", "l": "chemokine (C-C motif) ligand 5 binding", "d": ["Binding to chemokine (C-C motif) ligand 5."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296309", "l": "HCAR3 binds HCAR3 ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672957", "l": "PP2A dephosphorylates KSR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156682", "l": "PLK1 phosphorylates NUDC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983709", "l": "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761110", "l": "BHLHE22 homodimer binds intron 1 of CDH11 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836270", "l": "TFAP2A binds TFAP2C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46099", "l": "3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + dihydropinosylvin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34477", "l": "15-cis-phytoene + 2 diphosphate => 2 (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072572", "l": "poly-ADP-D-ribose binding", "d": ["Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31658", "l": "4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O <=> 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52183", "l": "(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63115", "l": "A + ascofuranol <=> AH2 + ascofuranone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35620", "l": "L-idarate => D-glucarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77677", "l": "an N-acylsphing-4-enine + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc => a globoside GalGb4Cer (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22522", "l": "all-trans-retinoate + H(+) + H2O2 => all-trans-retinal + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44684", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23497", "l": "5-hydroxypentanoate + acetyl-CoA => 5-hydroxy-pentanoyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23738", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) => 5-hydroxyisourate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34003", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 = 7-dehydrodesmosterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77221", "l": "a dolichyl phosphate + C-alpha-D-mannosyl-L-tryptophyl-[protein] + H(+) => a dolichyl beta-D-mannosyl phosphate + L-tryptophyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25978", "l": "(5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950183", "l": "IL12B binds IL23A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156682", "l": "PLK1 phosphorylates NUDC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419644", "l": "Transphosphorylation of pLIMK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162195", "l": "COQ4 decarboxylates MHDB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802927", "l": "BRAF and RAF fusion mutant dimers are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193776", "l": "Efflux of 24-hydroxycholesterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804402", "l": "TP53 binds POU4F1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757574", "l": "ALB binds PREDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55617", "l": "a carotenoid psi-end group => a carotenoid epsilon-end group", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21536", "l": "(3S)-hydroxy-3-methylglutaryl-CoA = 3-methyl-(2E)-glutaconyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.18", "l": "\"methylglutaconyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9823906", "l": "TBK1 is phosphorylated within the activated TLR4 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450027", "l": "Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674022", "l": "BRAP autoubiquitinates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29894", "l": "ATP + H2O + L-histidine(out) <=> ADP + H(+) + L-histidine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856464", "l": "MITF-M dimer binds MYO5A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36316", "l": "2 H(+) + hexadecanoyl-CoA + 2 NADPH => CoA + hexadecan-1-ol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047736", "l": "cellobiose epimerase activity", "d": ["Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56193", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247836", "l": "Retromer recycles WLS to the Golgi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69173", "l": "Joining of adjacent Okazaki fragments (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.554670414377497", "identifiers": [{"i": "GO:0140358", "l": "P-type transmembrane transporter activity", "d": ["Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869694", "l": "oxPL binds CD14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32089", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate => [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67494", "l": "a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+) => a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446372", "l": "Association of  PARVA with TESK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45492", "l": "phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684008", "l": "NBN binds KPNA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005055", "l": "laminin receptor activity", "d": ["Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9856871", "l": "MDH1 reduces OA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932284", "l": "PKC phosphorylates NFE2L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41650", "l": "ADP + N(5)-phenyl-L-glutamine + phosphate => aniline + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60564", "l": "2-deoxy-D-glucose + ATP = 2-deoxy-D-glucose 6-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354073", "l": "Autophosphorylation of PTK2 at Y397 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050511", "l": "undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357445", "l": "PAK1-3 dimer disassociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9854906", "l": "MITF-M-dependent PPARGC1A gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53195", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14585", "l": "gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030975", "l": "thiamine binding", "d": ["Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15879", "l": "D-glutamate + pyridoxal 5'-phosphate => 2-oxoglutarate + pyridoxamine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12511", "l": "loganate + S-adenosyl-L-methionine <=> loganin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51117", "l": "guanosine(6) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59576", "l": "anserine + H2O = beta-alanine + N(pros)-methyl-L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5631885", "l": "PRDX1 overoxidizes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30319", "l": "H(+) + NADH + O2 + theobromine = 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31276", "l": "(S)-3-hydroxy-2-methylpropanoate + NAD(+) => (S)-2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616214", "l": "RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, and MYB bind the CEBPA promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38993", "l": "1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+) => 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682377", "l": "LC3 de-lipidation by ATG4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373746", "l": "SEMA4D interacts with CD45 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331340", "l": "TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15369", "l": "2,3-dihydroxybenzoate + O2 = 2-carboxy-cis,cis-muconate + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.28", "l": "\"2,3-dihydroxybenzoate 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57474", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP => (E)-4-coumarate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008684", "l": "TBK1 phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015505", "l": "uracil:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333678", "l": "CPNEs bind PL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40186", "l": "O2 + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65607", "l": "(4R)-hydroxysphinganine + eicosanoyl-CoA <=> CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211405", "l": "Anthrax lef cleaves target cell MAP2K6 (MEK6) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050310", "l": "sulfite dehydrogenase activity", "d": ["Catalysis of the reaction: sulfite + 2 ferricytochrome c + H2O = sulfate + 2 ferrocytochrome c."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086410", "l": "CDK1 phosphorylates BORA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61418", "l": "cis-trans-nepetalactol => (S)-8-oxocitronellyl enol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619367", "l": "CaMKKs phosphorylate CAMK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47452", "l": "(2E,5Z)-tetradecadienoyl-CoA + H2O = (3S)-hydroxy-(5Z-tetradecenoyl)-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58511", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O <=> (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013979", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15051", "l": "D-glucose + GDP + H(+) => GDP-alpha-D-glucose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51686", "l": "(2E,6E)-farnesyl diphosphate + CDP => (2E,6E)-farnesyl phosphate + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001108", "l": "bacterial-type RNA polymerase holo enzyme binding", "d": ["Binding to a component of the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49445", "l": "(2-aminobenzoyl)acetyl-CoA + H2O => (2-aminobenzoyl)acetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41430", "l": "3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine => L-tyrosine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693598", "l": "ATM phosphorylates NBN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55083", "l": "ADP-alpha-D-glucose + D-fructose <=> ADP + H(+) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34754", "l": "ATP + N-acyl-15-methylhexadecasphing-4-enine <=> ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12890", "l": "L-gulonate + NAD(+) => 3-dehydro-L-gulonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40256", "l": "(2E)-hexadecenedioyl-CoA + H2O => (3R)-hydroxyhexadecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.47", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64594", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44299", "l": "2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA <=> 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76262", "l": "H(+)(in) + taurine(in) <=> H(+)(out) + taurine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60052", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 = a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31745", "l": "a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine => a 4'-hydroxyflavanone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20123", "l": "AMP + diphosphate + L-glutaminyl-tRNA(Gln) => ATP + L-glutamine + tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54622", "l": "2-hydroxyeicosanoyl-CoA + CO2 + succinate => 2-oxoglutarate + eicosanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941895", "l": "Formation of CDK4/6:CCND complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41800", "l": "acetyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69233", "l": "(Z)-3-hydroxypropyl glucosinolate + H2O => (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050445", "l": "asparagusate reductase activity", "d": ["Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD+ = asparagusate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005483", "l": "soluble NSF attachment protein activity", "d": ["Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59728", "l": "(2R)-ethylmalonyl-CoA = (2S)-ethylmalonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51482", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19344", "l": "2 H(+) + O2 + octane + 2 reduced [rubredoxin] <=> H2O + octan-1-ol + 2 oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56559", "l": "(2E,6E)-farnesyl diphosphate <=> delta-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853496", "l": "SCF:FBXL7 binds AURKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0016907", "l": "G protein-coupled acetylcholine receptor activity", "d": ["Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610653", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors bind to postsynaptic density proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114683", "l": "Phosphorylation of Platelet Sec-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938887", "l": "PML binds RUNX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71486", "l": "H2O + Met-enkephalin <=> L-phenylalanyl-L-methionine + L-tyrosylglycylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381545", "l": "Formation of the IGF:IGFBP5:ALS complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0005324", "l": "long-chain fatty acid transmembrane transporter activity", "d": ["Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48815", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74281", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB => a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139898", "l": "Caspase-8 activates BID by cleavage (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9855252", "l": "SDHA:SDHB binds to SDHC:SDHD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250962", "l": "botG LC cleaves target cell VAMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63614", "l": "prunetin-5-O-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033784", "l": "senecionine N-oxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + senecionine = H2O + NADP+ + senecionine N-oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928600", "l": "N-WASP binds ITSN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18800", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52951", "l": "deoxycholate + UDP-alpha-D-glucuronate <=> deoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63466", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP => (2E,6E,10E)-geranylgeraniol + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070095", "l": "fructose-6-phosphate binding", "d": ["Binding to fructose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218814", "l": "PAK2 autophorylates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006332", "l": "JAK2 transphosphorylates and is activated in response to Erythropoietin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653936", "l": "Formation of Ragulator complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893609", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenic acid + H2O [cytosolic] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848335", "l": "IL37 binds  IL18R1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.61", "l": "\"caspase-8\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-844447", "l": "NLRP1 senses MDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.90", "l": "\"isoflavone 2'-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68130", "l": "a fatty acid phytyl ester + CoA => a fatty acyl-CoA + phytol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53895", "l": "an S-prenyl-L-cysteine + H2O + O2 <=> a prenal + H2O2 + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73151", "l": "CoA(out) + FMN(in) = CoA(in) + FMN(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53501", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749253", "l": "Formation of MCM2-7 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10538", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69685", "l": "CHEK2 phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61042", "l": "(+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40698", "l": "1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol <=> 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19382", "l": "(S)-oxalosuccinate + H(+) => 2-oxoglutarate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73753", "l": "(R)-adrenaline(out) + 2 H(+)(in) => (R)-adrenaline(in) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11087", "l": "3-dehydro-L-gulonate + H(+) <=> CO2 + L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047473", "l": "D-alanine [D-alanyl carrier protein] ligase activity", "d": ["Catalysis of the ATP-dependent activation of D-alanine and its transfer as a thiol ester to the phosphopantheinyl prosthetic group of a D-alanyl carrier protein, according to the reaction: ATP + D-alanine + a [D-alaninyl carrier protein] = a D-alanyl-[D-alanyl carrier protein] + AMP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018825", "l": "triethanolamine lyase activity", "d": ["Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051718", "l": "DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA)."], "t": []}, {"i": "REACT:R-HSA-5334151", "l": "DNMT1 methylates cytosine in hemimethylated DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624951", "l": "TNPO1 binds KIF17 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69430", "l": "arsenic triglutathione + 3 H2O => arsenite + 3 glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55977", "l": "glutathione + thiosulfate => H(+) + S-sulfanylglutathione + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64861", "l": "(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine => (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43763", "l": "acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399711", "l": "Activation of Ca impermeable AMPA receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74056", "l": "D-cysteine(out) + L-alanine(in) => D-cysteine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-481044", "l": "Surface deployment of platelet alpha granule membrane components (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73052", "l": "hydrogencarbonate(in) + taurocholate(out) => hydrogencarbonate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36841", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19509", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 2 H(+) + L-erythro-biopterin + 2 NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.33", "l": "\"pteridine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36260", "l": "a 1-(1-hydroxyalkyl)-sn-glycerol => an aldehyde + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41382", "l": "4-methylphenol + H2O + NAD(+) => H(+) + NADH + O2 + toluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78640", "l": "acetyl-CoA + tetracosanoyl-CoA => 3-oxohexacosanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65783", "l": "2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75222", "l": "H2O + L-fucono-1,5-lactone <=> H(+) + L-fuconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54411", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0003842", "l": "1-pyrroline-5-carboxylate dehydrogenase activity", "d": ["H2O + L-glutamate 5-semialdehyde + NAD+ = 2 H+ + L-glutamate + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371582", "l": "HSBP1 binds HSF1 trimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611852", "l": "ADRB3 bind ADR,NAd (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036434", "l": "nitronate monooxygenase (FMN-linked) activity", "d": ["Catalysis of the reaction: ethylnitronate + FMNH(2) + O2 = acetaldehyde + FMN + H2O + H+ + nitrite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48749", "l": "D-threitol + NAD(+) => D-erythrulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43706", "l": "diphosphate + tetradecanoyl-AMP => ATP + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57873", "l": "(E)-2,4-dihydroxycinnamoyl-CoA => CoA + umbelliferone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102729", "l": "6-oxocampestanol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 6-oxocampestanol + O2 + NADPH = cathasterone + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44456", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34621", "l": "1-deoxy-11beta-hydroxypentalenate + CO2 + succinate => 1-deoxypentalenate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140806", "l": "SERPINC1 binds SERPINC1 activators (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836270", "l": "TFAP2A binds TFAP2C (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507871", "l": "Aquaporins passively transport glycerol out of cells (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44054", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + CoA => alpha,alpha-trehalose + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66341", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38214", "l": "hexadecane-1,2-diol + 2 hexadecanoyl-CoA <=> 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38921", "l": "choline + H(+) + sphing-4-enine 1-phosphate => H2O + sphing-4-enine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624668", "l": "CEBPA binds CDKN1A (p21) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-606349", "l": "Mis18 complex binds the centromere (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008932", "l": "lytic endotransglycosylase activity", "d": ["Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends."], "t": []}, {"i": "EC:4.2.2.n2", "l": "\"peptidoglycan lytic endotransglycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41480", "l": "an acyl-CoA + episterol = an episterol ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29143", "l": "a ubiquinol + 2 H(+)(in) + nitrate = a ubiquinone + 2 H(+)(out) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9838081", "l": "LONP1 degrades mitochondrial matrix proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015043", "l": "leghemoglobin reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49585", "l": "D-erythrulose 1-phosphate => L-erythrulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56403", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417843", "l": "P2Y13 binds ADP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674022", "l": "BRAP autoubiquitinates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825836", "l": "MITF-M dimer binds the MET gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018808", "l": "RAC3 binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13108", "l": "glycerol 2-phosphate + H2O <=> glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022764", "l": "SGK1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67114", "l": "H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65043", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396029", "l": "Latent TGF-beta-3 binds integrins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33157", "l": "a 1-acyl-sn-glycerol + phosphate => a 1-acyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450074", "l": "Interleukin-3 receptor alpha subunit binds Interleukin-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052734", "l": "shikimate 3-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: shikimate + NAD+ = 3-dehydroshikimate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805035", "l": "TP53 binds STK11 and NUAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.104", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19706", "l": "CoA + hexadecanal + NAD(+) => H(+) + hexadecanoyl-CoA + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351849", "l": "Caspase-mediated cleavage of Etk (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33315", "l": "a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605624", "l": "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419428", "l": "S1PR2-5 bind S1P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25181", "l": "acetyl-CoA + putrescine = CoA + H(+) + N-acetylputrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19417", "l": "[phosphate](n) + a dolichyl diphosphate = [phosphate](n+1) + a dolichyl phosphate", "d": [], "t": []}, {"i": "EC:2.7.4.20", "l": "\"dolichyl-diphosphate--polyphosphate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49276", "l": "CTP + phytyl phosphate = CDP + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374665", "l": "DCC interaction with SIAH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24944", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) => (4S)-4-hydroxy-L-glutamate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54457", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400204", "l": "PPARA binds RXRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247839", "l": "Retromer associates with WLS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68373", "l": "L-asparagine + pyruvate => 2-oxosuccinamate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14442", "l": "acetyl-CoA + gentamicin C => CoA + H(+) + N(3)-acetylgentamycin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33439", "l": "glyoxal + H2O + O2 = glyoxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16784", "l": "a fatty acyl-CoA + H2O <=> a fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28024", "l": "AMP + diphosphate + octanoyl-[ACP] => ATP + holo-[ACP] + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53245", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.4", "l": "\"Gly-Xaa carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66495", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22136", "l": "7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 = chlorophyllide b + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60460", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.-", "l": "\"Transaminases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63235", "l": "(2E)-octenoyl-CoA + H(+) + NADH <=> NAD(+) + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52255", "l": "a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17683", "l": "2-methyl-3-oxopropanoate + H(+) + NADH => 3-hydroxy-2-methylpropanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9859172", "l": "DLD dimer dehydrogenates dihydrolipoyl (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043727", "l": "5-amino-4-imidazole carboxylate lyase activity", "d": ["Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63850", "l": "2 3',4'-dihydroxyaurone + 2 H2O => 2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045545", "l": "syndecan binding", "d": ["Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14301", "l": "4-pyridoxolactone + H2O = 4-pyridoxate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.27", "l": "\"4-pyridoxolactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59339", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + A <=> AH2 + demethylspheroidene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50498", "l": "CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein] => acetyl-CoA + N-terminal glycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42234", "l": "1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69735", "l": "phenylsuccinate + succinyl-CoA = 2-phenylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25061", "l": "(E)-cinnamate + H(+) + NADH + O2 <=> (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78769", "l": "1,5-anhydro-D-erythro-hex-1-en-3-ulose + luteolin => 3''-dehydroorientin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9650165", "l": "ASIC trimers bind H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28857", "l": "H(+)(out) + melibiose(out) => H(+)(in) + melibiose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102049", "l": "indole-3-acetyl-methionine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-methionine + ATP(4-) = H+ + indole-3-acetyl-methionine + AMP(2-) + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462041", "l": "HNP1-4 are released into phagocytic vacuoles (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61223", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74427", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38911", "l": "avenacoside B + H2O = 26-desgluco-avenacoside B + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.188", "l": "\"avenacosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55984", "l": "(R)-mandelonitrile + UDP-alpha-D-glucose = (R)-prunasin + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.354", "l": "\"(R)-mandelonitrile beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45780", "l": "(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41377", "l": "1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58614", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-octanoylglycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77720", "l": "a neolactoside IV(3)-alpha-NeuGc-nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => a neolactoside IV(4)-beta-GalNAc-IV(3)-alpha-NeuGc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799097", "l": "ATM phosphorylates ZNF420 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57187", "l": "L-cysteinyl-[protein] + methylglyoxal <=> S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709601", "l": "Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76652", "l": "3-methylbutanal + H2O + NADP(+) => 3-methylbutanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67857", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] => 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17427", "l": "acetyl-CoA + CO2 + NADPH => CoA + NADP(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17043", "l": "AMP + 2 H(+) + sulfate => adenosine 5'-phosphosulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9823932", "l": "Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42821", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 => H2O + 2 NADP(+) + tetracenomycin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698926", "l": "HCMV Genome Replication Completion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70848", "l": "L-arginine(in) + L-cysteine(out) + Na(+)(out) => L-arginine(out) + L-cysteine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72582", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O <=> (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46642", "l": "7alpha-hydroxy-5beta-cholestan-3-one + NADP(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033406", "l": "UCC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UCC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54902", "l": "hexadecanoyl-[ACP] + NAD(+) => (2E)-hexadecenoyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19418", "l": "[phosphate](n) + a dolichyl diphosphate => [phosphate](n+1) + a dolichyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51526", "l": "magnoflorine + S-adenosyl-L-homocysteine => (S)-corytuberine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22885", "l": "glyoxylate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247844", "l": "WNT ligands traffic to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390846", "l": "D2D3,4 bind to DA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78373", "l": "NAD(+) + sulfinamide glutathione => H(+) + NADH + S-nitrosoglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47773", "l": "a guanosine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43157", "l": "guanosine(9) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27989", "l": "hydroxyacetone + NADP(+) <=> H(+) + methylglyoxal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046571", "l": "aspartate-2-keto-4-methylthiobutyrate transaminase activity", "d": ["Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21939", "l": "carbamoyl phosphate + putrescine <=> H(+) + N-carbamoylputrescine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17409", "l": "(S)-coclaurine + S-adenosyl-L-methionine = (S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.140", "l": "\"(S)-coclaurine-N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43454", "l": "4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexanoyl-CoA + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42407", "l": "H2O + lactose 6-phosphate <=> beta-D-glucose + D-galactose 6-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55352", "l": "all-trans-retinol = 13-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9825772", "l": "SIRT1 deacetylates HINT1 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614614", "l": "Cysteine is degraded to serine and H2S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111956", "l": "Calmodulin activates Cam-PDE 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10813", "l": "H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + N-succinyl-L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928625", "l": "PAKs autophosphorylate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676229", "l": "WIPIs bind PI3P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52008", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28259", "l": "cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate => cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25960", "l": "benzoin + NADP(+) = benzil + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222417", "l": "TrxA reactivates AhpC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72482", "l": "citrate(out) + trans-aconitate(in) <=> citrate(in) + trans-aconitate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6794346", "l": "NRXNs bind NLGNs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236971", "l": "Peptide loading on MHC class I in phagosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0005085", "l": "guanyl-nucleotide exchange factor activity", "d": ["Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24048", "l": "phosphate + sucrose = alpha-D-glucose 1-phosphate + D-fructose", "d": [], "t": []}, {"i": "EC:2.4.1.7", "l": "\"sucrose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033161", "l": "mitogen-activated protein kinase kinase kinase kinase binding", "d": ["Binding to a mitogen-activated protein kinase kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60852", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619355", "l": "CaMKK autophosphorylates in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50224", "l": "3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3134954", "l": "DHX9 binds DNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30613", "l": "AH2 + all-trans-neurosporene => A + all-trans-zeta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34803", "l": "2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA = bisdemethoxycurcumin + 2 CO2 + 3 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.211", "l": "\"bisdemethoxycurcumin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030297", "l": "transmembrane receptor protein tyrosine kinase activator activity", "d": ["Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647746", "l": "EML4 trimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391939", "l": "TP receptor can bind thromboxane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928619", "l": "PAK1 binds RAC1:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22915", "l": "L-valine + pyruvate <=> 3-methyl-2-oxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381446", "l": "Thrombin proteolyzes IGF:IGFBP3:ALS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37115", "l": "sphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785898", "l": "IL4R binds JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050120", "l": "N-acetylhexosamine 1-dehydrogenase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine + H2O + NAD+ = N-acetyl-D-glucosaminate + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77536", "l": "H2O + L-methionyl-tRNA(Leu) => H(+) + L-methionine + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0005178", "l": "integrin binding", "d": ["Binding to an integrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69276", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate = but-3-enenitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665407", "l": "PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47024", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873946", "l": "OTUD3 deubiquitinates PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36632", "l": "D-ribulose 1,5-bisphosphate + O2 => (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55340", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20415", "l": "glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine => glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13203", "l": "guanidinoacetate + L-ornithine => glycine + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21995", "l": "acetyl-CoA + L-lysyl-[histone] <=> CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42573", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) => 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21527", "l": "3-methyl-2-oxobutanoate + acetyl-CoA + H2O <=> (2S)-2-isopropylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48635", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190693", "l": "Synthesis of GJB1 (Cx32) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018804", "l": "RAC3 GEFs activate RAC3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56859", "l": "A + an aldehyde + H2O <=> a carboxylate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44038", "l": "12,13-dihydroxy-(9Z)-octadecenoate => 12,13-epoxy-(9Z)-octadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0004509", "l": "steroid 21-monooxygenase activity", "d": ["Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O2 = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66095", "l": "3-phenylpyruvate + L-kynurenine <=> H2O + kynurenate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78752", "l": "(R)-carnitine + a fatty acyl-CoA => a fatty acyl-L-carnitine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70039", "l": "3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55929", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] => fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62182", "l": "diphosphate + viteagnusin D => H2O + peregrinol diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9859172", "l": "DLD dimer dehydrogenates dihydrolipoyl (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296309", "l": "HCAR3 binds HCAR3 ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015530", "l": "shikimate transmembrane transporter activity", "d": ["Enables the transfer of shikimate from one side of a membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28141", "l": "H2O + streptothricin F <=> streptothricin F acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64791", "l": "(E)-cinnamate + ATP + CoA <=> (E)-cinnamoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674095", "l": "PDGFRs bind type II TKI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41191", "l": "1-hexadecanoyl-2-propionyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139920", "l": "Translocation of tBID to mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42492", "l": "3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 = 3'-N-debenzoyltaxol + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64751", "l": "H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine <=> 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31744", "l": "a 4'-hydroxyflavanone + S-adenosyl-L-methionine => a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53260", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 1beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018589", "l": "di-n-butyltin dioxygenase activity", "d": ["Catalysis of the reaction: dibutyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54140", "l": "cytidine(49) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34583", "l": "2-oxoglutarate + O2 + pentalenolactone D = CO2 + H2O + pentalenolactone E + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68654", "l": "H(+) + hydrogen sulfide + L-homolanthionine => 2 L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27631", "l": "ethylene glycol + NAD(+) => glycolaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15475", "l": "flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP => flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102466", "l": "beta-carotene 2,2'-beta-hydroxylase activity", "d": ["Catalysis of the reaction: beta-carotene + 2 NADH + 2 H+ + 2 O2 = (2R,2'R)-dihydroxy-all-trans-beta-carotene + 2 NAD + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693198", "l": "RHOD binds effectors at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77930", "l": "H2O + N-(4-aminobutylpyrrolinium) ion + O2 <=> H2O2 + N-(4-oxobutylpyrrolinium) ion + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10423", "l": "pyruvate + taurine <=> L-alanine + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76392", "l": "glycylglycylglycine(out) + n H(+)(out) => glycylglycylglycine(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72137", "l": "putrescine(in) => putrescine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661432", "l": "BIL binds ALB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648268", "l": "HTR1A binds HTR1A antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031876", "l": "secretin receptor binding", "d": ["Binding to a secretin receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032033", "l": "myosin II light chain binding", "d": ["Binding to a light chain of a myosin II complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74861", "l": "H2O + norsalsolinol => dopamine + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.151", "l": "\"premnaspirodiene oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980078", "l": "NOTCH1 stimulates HES5 transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45413", "l": "H2O + prostaglandin D2-1-glycerol ester => glycerol + H(+) + prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419861", "l": "Melanospin is stimulated by light (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.18", "l": "\"4-hydroxyphenylacetate 1-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625416", "l": "Anterograde IFT (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75973", "l": "H(+) + NADPH + neomorphinone => NADP(+) + neomorphine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419011", "l": "Transhomodimerization of Nectins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696457", "l": "BDH2 dehydrogenates 3HBA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.14", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58531", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH <=> (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.2", "l": "\"pepsin B\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10253", "l": "H(+) + hydrogen sulfide + O-phospho-L-serine => L-cysteine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76031", "l": "2 H2O2 => O2 + 2 H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46468", "l": "an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O = ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62470", "l": "3,4-dihydroxybenzoyl-5'-AMP + diphosphate => 3,4-dihydroxybenzoate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9822539", "l": "VWF multimer binds to collagen type I (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53586", "l": "7-oxoresolvin D2 + H(+) + NADH => NAD(+) + resolvin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67849", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693009", "l": "Expression of AMH in testis differentiation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72458", "l": "fumarate(out) + 3 H(+)(out) <=> fumarate(in) + 3 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51975", "l": "an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59514", "l": "O-acetyl-L-seryl-[protein] + salicylate => acetylsalicylate + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15672", "l": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP <=> a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12701", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate", "d": [], "t": []}, {"i": "EC:1.17.4.2", "l": "\"ribonucleoside-triphosphate reductase (thioredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692941", "l": "BACE1:GGA1,2,3 translocates from plasma membrane to endosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69570", "l": "4-amino-4-deoxychorismate + L-glutamate + NH4(+) => (2S)-2-amino-4-deoxychorismate + H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168456", "l": "Growth hormone receptor binds Lyn (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30148", "l": "FADH2 + NAD(+) => FAD + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805507", "l": "APAF1 binds AVEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56580", "l": "6-thioguanine + S-adenosyl-L-methionine = 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41057", "l": "1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55882", "l": "[aequorin] => apo-[aequorin]--coelenterazine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373748", "l": "SEMA4D interacts with CD72 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44313", "l": "1-tetradecanoylglycerol + H2O => glycerol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654651", "l": "Activated FGFR4 binds FRS3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44828", "l": "(R)-carnitine + decanoyl-CoA = CoA + O-decanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679239", "l": "ULK complex translocates to the ER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69555", "l": "dihydroxyacetone phosphate + L-glutamate <=> (S)-serinol phosphate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381087", "l": "Dimerization of PERK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66741", "l": "ATP + H2O + N-acetyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140864", "l": "histone H2AK129 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-129 residue."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39272", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA => (2E,15Z)-tetracosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004698", "l": "calcium,diacylglycerol-dependent serine/threonine kinase activity", "d": ["Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9824986", "l": "XPO1-dependent export of p-S69,S73 MITF-M (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24601", "l": "H2O + O2 + sulfite => H2O2 + sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10763", "l": "citrate <=> acetate + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44956", "l": "(2E)-hexenoyl-CoA + H(+) + NADPH = hexanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60770", "l": "3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate => 3 2-oxoglutarate + gibberellin A12 + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28186", "l": "aminoacetone + H2O + O2 = H2O2 + methylglyoxal + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190256", "l": "FGFR1c binds to FGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876472", "l": "NPC2 binds CHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858252", "l": "HDLBP binds HDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63811", "l": "ATP + citrate + spermidine <=> AMP + diphosphate + H(+) + N(8)-citryl-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28344", "l": "dIMP + diphosphate + H(+) => dITP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70510", "l": "LDH tetramer oxidises LACT to PYR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41561", "l": "(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 => (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66645", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + trichobrasilenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24002", "l": "a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein] => a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678843", "l": "ISGylation of protein translation regulator 4EHP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48886", "l": "3,8-divinyl protochlorophyllide a + H(+) + NADPH => NADP(+) + protochlorophyllide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55368", "l": "(R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51822", "l": "AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in) => ATP(in) + CoA(in) + decanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51747", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A <=> a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69161", "l": "agmatine + H2O + O2 => H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58437", "l": "4-methylpentan-1-ol + NADP(+) => 4-methylpentanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937807", "l": "SRC phosphorylates RUNX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481010", "l": "Surface deployment of platelet dense granule membrane components (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48098", "l": "2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine => L-arginyl-[protein] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50131", "l": "NAD(+) + resolvin D1 <=> 17-oxoresolvin D1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047535", "l": "2-alkyn-1-ol dehydrogenase activity", "d": ["Catalysis of the reaction: 2-butyne-1,4-diol + NAD+ = 4-hydroxy-2-butynal + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70692", "l": "ornithine => putrescine + CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854222", "l": "TBC1D3 associates with RAB5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57125", "l": "2-oxoglutaramate => 2-hydroxy-5-oxoproline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15827", "l": "AZD1979 oxetane hydrolysis product + H(+) => AZD1979 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18706", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48151", "l": "ganglioside GT1b (d18:1(4E)/18:0) + H2O <=> ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78693", "l": "[(1->2)-beta-D-glucosyl](n-1) + a beta-D-glucosyl-(1->2)-D-glucoside => [(1->2)-beta-D-glucosyl](n) + a D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25180", "l": "4-methyl-2-oxopentanoate + CoA + NAD(+) <=> 3-methylbutanoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66307", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611368", "l": "CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14214", "l": "ATP + beta-D-fructose 1-phosphate => ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13140", "l": "cycloartenol + S-adenosyl-L-methionine <=> cyclolaudenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74986", "l": "Elongation of pre-rRNA transcript (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15112", "l": "2-dehydro-3-deoxy-D-gluconate + NADP(+) <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047479", "l": "trypanothione synthase activity", "d": ["Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693125", "l": "RHOF binds effectors at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38868", "l": "uridine(516) in 16S rRNA => pseudouridine(516) in 16S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20129", "l": "AMP + H2O = adenine + D-ribose 5-phosphate", "d": [], "t": []}, {"i": "EC:3.2.2.4", "l": "\"AMP nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652165", "l": "MAP2K mutants constitutively phosphorylate MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47829", "l": "a ganglioside GT1b + H2O => a ganglioside GD1b + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40946", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56392", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24670", "l": "H2O + hypoxanthine + NAD(+) = H(+) + NADH + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26103", "l": "cis-homoaconitate + H2O => (2R)-homocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62377", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H2O => (S)-lactate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033787", "l": "cyanocobalamin reductase (cyanide-eliminating) activity", "d": ["Catalysis of the reaction: cob(I)alamin + hydrogen cyanide + NADP+ = cyanocob(III)alamin + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67856", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] = 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844598", "l": "DIO2 gene expression is stimulated by EBF2 and repressed by ZNF423 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847534", "l": "RAB43 hydrolyses GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46946", "l": "H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH => (S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0009976", "l": "tocopherol cyclase activity", "d": ["Catalysis of the reactions: delta-tocopherol = 2-methyl-6-phytyl-1,4-benzene-1,4-diol, gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol. delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol gamma-tocotrienol, and = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163625", "l": "Glucagon binds to Glucagon receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62674", "l": "an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine => a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33206", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70003", "l": "6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase] = cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41386", "l": "H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710354", "l": "GSDME (1-270) binds cardiolipin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004392", "l": "heme oxygenase (decyclizing) activity", "d": ["Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53513", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029521", "l": "NR1H2,3 binds the ABCG5 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9854961", "l": "SDHAF4 binds to FAD-SDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36189", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1-O-alkyl-2-acyl-sn-glycerol + CDP-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045238", "l": "CXCR2 chemokine receptor binding", "d": ["Binding to a CXCR2 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102737", "l": "p-coumaroyltriacetic acid synthase activity", "d": ["Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + H2O + 3 malonyl-CoA = 4 coenzyme A + 3 carbon dioxide + p-coumaroyltriacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31508", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine => H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71928", "l": "2 Na(+)(out) + tauroursodeoxycholate(out) => 2 Na(+)(in) + tauroursodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1370505", "l": "PRLR is phosphorylated at Ser-349 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61044", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42148", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13784", "l": "an L-alpha-amino acid + H2O + O2 <=> a 2-oxocarboxylate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690494", "l": "RHOB translocates to the endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120301", "l": "histone lactyltransferase (CoA-dependent) activity", "d": ["Catalysis of the reaction: (L-lysyl-[histone] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[histone]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66315", "l": "an alpha-mannosylinositol-1-phosphoceramide + H2O <=> a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73893", "l": "ADP + gamma-L-glutamylspermidine + H(+) + phosphate => ATP + L-glutamate + spermidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265177", "l": "Exocyst complex formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37787", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210294", "l": "Interaction of PECAM-1 and SHP-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14316", "l": "2-iodophenol + S-adenosyl-L-methionine <=> 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694433", "l": "MIA2 binds PREB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218832", "l": "CDC42:GTP binds PAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74978", "l": "a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP] <=> a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33049", "l": "(+)-6-endo-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin] => (1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68135", "l": "phytol + tetradecanoyl-CoA <=> CoA + tetradecanoate phytyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62900", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46610", "l": "ADP + H(+) + O-phospho-L-threonyl-[protein] => ATP + L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.382", "l": "\"methoxylated aromatic compound--corrinoid protein Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805103", "l": "AURKA phosphorylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11897", "l": "7alpha-hydroxycholesterol + NAD(+) => 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047770", "l": "carboxylate reductase activity", "d": ["Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050085", "l": "mannitol 2-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-mannitol + NADP+ = D-fructose + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909718", "l": "Formation of p-STAT1 homodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66302", "l": "an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+) => an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634850", "l": "NPAS4 binds ARNT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0009674", "l": "potassium:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102766", "l": "naringenin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-naringenin(1-) + S-adenosyl-L-methionine = sakuranetin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17394", "l": "3-maleylpyruvate => 3-fumarylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170846", "l": "TGFBR2 recruits TGFBR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28157", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35280", "l": "acetyl-CoA + hexadecanoyl-CoA => 3-oxooctadecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75213", "l": "Cu(+)(in) => Cu(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73600", "l": "CDP(in) + CTP(out) => CDP(out) + CTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78213", "l": "4-methyl-2-oxopentanoate + H2O2 + NH4(+) => D-leucine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034576", "l": "N-isopropylacetanilide amidohydrolase activity", "d": ["Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113429", "l": "Elongating transcript encounters a lesion in the template (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035244", "l": "protein-arginine C-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein. This modification has been detected in anaerobic bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830376", "l": "Expression of MECOM (EVI1) in the nephric duct (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66056", "l": "indole-3-pyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75296", "l": "chloride(in) + sulfate(out) => chloride(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23401", "l": "7,8-dihydroxykynurenate + O2 => 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21980", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}, {"i": "EC:2.8.2.8", "l": "\"[heparan sulfate]-glucosamine N-sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48535", "l": "a ganglioside GQ1c (d18:1(4E)) + H2O <=> a ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11428", "l": "beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14557", "l": "H2O + raucaffricine = D-glucose + vomilenine", "d": [], "t": []}, {"i": "EC:3.2.1.125", "l": "\"raucaffricine beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176956", "l": "Formation of GINS complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32816", "l": "Hg(2+)(in) => Hg(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78129", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204500", "l": "CyP60 chaperones Basigin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430135", "l": "p-SLP-76 binds ADAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419351", "l": "PAF receptor binds platelet activating factor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40619", "l": "H2O + tridodecanoylglycerol = 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74107", "l": "discoidol + O2 + reduced [NADPH--hemoprotein reductase] = acetone + discodiene + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162186", "l": "COQ3 methylates DeMQ10H2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11963", "l": "2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate <=> (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63809", "l": "ATP + citrate + spermidine => AMP + diphosphate + H(+) + N(8)-citryl-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46579", "l": "H(+) + NADPH + O2 + sitosterol <=> 2 H2O + NADP(+) + stigmasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35220", "l": "8-oxo-dADP + H2O => 8-oxo-dAMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18654", "l": "barbiturate + H2O => 3-oxo-3-ureidopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388814", "l": "Grb2 binds CD28 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17056", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate <=> beta-D-fructose 6-phosphate + D-erythrose 4-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46423", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430135", "l": "p-SLP-76 binds ADAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70241", "l": "PCK1 phosphorylates OA to yield PEP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805943", "l": "S100A1 binds TLR4:LY96 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38682", "l": "ATP + H2O + sphinganine(in) <=> ADP + H(+) + phosphate + sphinganine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047207", "l": "1,2-beta-fructan 1F-fructosyltransferase activity", "d": ["Catalysis of the reaction: [(1->2)-beta-D-fructosyl](n) + [(1->2)-beta-D-fructosyl](m) = [(1->2)-beta-D-fructosyl](n+1) + [(1->2)-beta-D-fructosyl](m-1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34161", "l": "CoA + H(+) + UDP-N,N'-diacetylbacillosamine => acetyl-CoA + UDP-N-acetylbacillosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25679", "l": "ATP + O-phospho-L-serine + tRNA(Cys) => AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170026", "l": "UCP1 imports a proton (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36965", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA => (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008983", "l": "protein-glutamate O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41749", "l": "3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78158", "l": "RNA(n)-3'-guanine ribonucleotide <=> 2',3'-cyclophospho-GMP + RNA(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50507", "l": "acetyl-CoA + N-terminal L-seryl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31793", "l": "(13S)-edaxadiene + diphosphate => H2O + tuberculosinyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13575", "l": "[(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP => [(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9028730", "l": "Activated NTRK2 binds FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2752115", "l": "SPP1 (osteopontin) binds CD44 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430096", "l": "GP1b-IX-V binds filamin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9846501", "l": "B3GNT5 transfers GlcNAc to LacCer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44906", "l": "alpha-D-glucose + phosphate => alpha-D-glucose 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76798", "l": "2-aminopropan-1-ol + H2O + NAD(+) <=> H(+) + hydroxyacetone + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429157", "l": "ABCC4 accumulation of dense granule contents (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74553", "l": "L-serine + tRNA(Ser) => H2O + L-seryl-tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30488", "l": "H(+) + N,N-dihydroxy-L-isoleucine => (1E,2S)-2-methylbutanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46433", "l": "(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56941", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.73", "l": "\"albendazole monooxygenase (sufoxide-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209220", "l": "Liberation of CI from SU(FU) repression (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0004300", "l": "enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035403", "l": "histone H3T6 kinase activity", "d": ["Catalysis of the reaction: histone H3-threonine (position 6) + ATP = histone H3-phosphothreonine (position 6) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 6 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75804", "l": "butanoate(out) + Na(+)(out) => butanoate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53698", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46122", "l": "4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990649", "l": "inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60081", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39735", "l": "3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22219", "l": "(E)-caffeate + O2 <=> 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12759", "l": "H(+) + NADPH + zeatin => dihydrozeatin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396009", "l": "STING binds c-di-GMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49193", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51696", "l": "desmethylxanthohumol + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + xanthohumol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39921", "l": "1-O-(alk-1-enyl)-sn-glycerol + phosphate => 1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17333", "l": "O-acetyl-L-serine + zeatin = acetate + H(+) + L-lupinate", "d": [], "t": []}, {"i": "EC:2.5.1.50", "l": "\"zeatin 9-aminocarboxyethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9860264", "l": "TASL is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623384", "l": "α1-agonists bind ADRA1A,B,D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36372", "l": "(2S)-hydroxybutanoate + NAD(+) => 2-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2530445", "l": "CD59 inhibits MAC formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18447", "l": "5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => H2O + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70971", "l": "ACO2 isomerizes citrate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74363", "l": "coproporphyrin III(out) = coproporphyrin III(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68266", "l": "(6S)-5,6,7,8-tetrahydrofolate + formaldehyde => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981728", "l": "Factor H binds to membrane-associated C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17241", "l": "an alpha-amino acid ester + H2O = an alcohol + an alpha-amino acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.43", "l": "\"alpha-amino-acid esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21588", "l": "N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.38", "l": "\"N-acetyl-gamma-glutamyl-phosphate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952069", "l": "HDAC4 deacetylates RUNX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47328", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174157", "l": "Degradation of multiubiquitinated Cyclin B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19966", "l": "S,S-dimethyl-beta-propiothetin => acrylate + dimethyl sulfide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374298", "l": "Opioid receptors bind opioid peptides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53221", "l": "16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709098", "l": "DHFR dimer reduces FOLA to DHF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396124", "l": "AGRN binds Laminins with gamma-1 subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73955", "l": "3,4-dihydroxystyrene + H(+) + NADH = 4-ethylcatechol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63515", "l": "biphenyl-2,2'-diol + H(+) + NADH + O2 <=> biphenyl-2,2',3-triol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12036", "l": "(S)-3-(imidazol-5-yl)lactate + NAD(+) = 3-(imidazol-5-yl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56761", "l": "24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191402", "l": "Reduction of presqualene diphosphate to form squalene (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48639", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71172", "l": "H(+)(in) + L-cysteine(out) + Na(+)(out) => H(+)(out) + L-cysteine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46336", "l": "3-oxochola-4,17-dien-22-oyl-CoA + H2O = 17-hydroxy-3-oxochol-4-en-22-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.745825357329565", "identifiers": [{"i": "GO:0140938", "l": "histone H3 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a histone H3 = S-adenosyl-L-homocysteine + a methylated histone H3. Histone methylation generally occurs on either an arginine or a lysine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53877", "l": "a cytidine in tRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-445079", "l": "Phosphorylation of L1 by ERK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33456", "l": "4alpha-carboxyzymosterol + NADP(+) => CO2 + NADPH + zymosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851979", "l": "BTNL9 binds immune cell surfaces (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811479", "l": "ING2 recruits EP300 to TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72568", "l": "dehydroepiandrosterone 3-sulfate(in) + propanoate(out) => dehydroepiandrosterone 3-sulfate(out) + propanoate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37460", "l": "1D-myo-inositol hexakisphosphate + ATP => 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.69", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.28", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603554", "l": "NTRK3(496-641):NELFB translocates to mitochondrion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78946", "l": "[DsrC protein]-trisulfide + 3 H2O + NAD(+) <=> [DsrC protein]-dithiol + 3 H(+) + NADH + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67719", "l": "NADPH + 2 oxidized [2Fe-2S]-[protein] <=> H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754129", "l": "CDK6 inhibitors bind CDK6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683774", "l": "p-T68-CHEK2 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23421", "l": "alpha,alpha-trehalose 6-phosphate + H2O => alpha,alpha-trehalose + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41180", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39806", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) <=> (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65389", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O => a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30110", "l": "D-serine + NADP(+) <=> 2-aminomalonate semialdehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77857", "l": "2-dehydro-D-glucose + H2O2 + L-phenylalanine => H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-phenylalanine + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30237", "l": "2 H(+) + L-glutamate + NADH => H2O + L-glutamate 5-semialdehyde + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17775", "l": "AMP + diphosphate + L-cysteinyl-tRNA(Cys) => ATP + L-cysteine + tRNA(Cys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008707", "l": "4-phytase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8979071", "l": "KDM6B binds iron (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373075", "l": "Metabotropic glutamate receptors bind glutamate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632182", "l": "PRMT1 methylates ESRs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40988", "l": "EDTA + 2 FMNH2 + 2 O2 => ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61370", "l": "4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate => 4-methylumbelliferone sulfate(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391933", "l": "EP3 receptor can bind PGE2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40050", "l": "1,2,3-trioctanoylglycerol + H2O <=> 1,2-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14692", "l": "4-chlorophenylacetate + NADH + O2 <=> 3,4-dihydroxyphenylacetate + chloride + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690414", "l": "SRY and NR5A1 (SF1) bind SOX9 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63023", "l": "(9Z,12Z)-octadecadienamide + H2O <=> (9Z,12Z)-octadecadienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875568", "l": "RAPGEF1 activates RAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52538", "l": "AMP + dGDP + H(+) => adenosine + dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.26", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55066", "l": "4-methylpentanoate + CoA + H(+) => 4-methylpentanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16871", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2219524", "l": "PDPK1 binds PIP2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10691", "l": "H2O + streptomycin 6-phosphate <=> phosphate + streptomycin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700175", "l": "Active ALK phosphorylates SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78281", "l": "diphosphate + somaliensene A => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70134", "l": "3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37025", "l": "(6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38913", "l": "26-desgluco-avenacoside B + D-glucose => avenacoside B + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31808", "l": "(2E,6E)-farnesyl diphosphate => alpha-guaiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59683", "l": "D-maltopentaose + O2 <=> D-maltopentaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52830", "l": "(3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-isodihydrocarvone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209840", "l": "Two DITs combine to form thyroxine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40447", "l": "(2R)-pristanoyl-CoA = (2S)-pristanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56626", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+) => 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264622", "l": "Cho is acetylated to AcCho by CHAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33769", "l": "a (2E)-enoyl-CoA + H2O => a 3-hydroxy-fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750660", "l": "Glycine conjugates translocates from mitochondrial matrix to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65096", "l": "a 2-acylglycerol + hexadecanoyl-CoA = a 1-hexadecanoyl-2-acylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865275", "l": "PDGF-BB clevage by Furin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689861", "l": "Recruitment of XPA and release of CAK  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20562", "l": "3-hydroxypyruvate + H(+) => CO2 + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830762", "l": "Expression of WNT11 in the nephric duct (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10166", "l": "H2O + phosphoenolpyruvate => (2R)-2-phosphoglycerate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47244", "l": "(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0052840", "l": "inositol diphosphate tetrakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: diphospho-1D-myo-inositol tetrakisphosphate + H2O = 1D-myo-inositol pentakisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035281", "l": "NR1H3 gene transcription regulated by NR1H2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033811", "l": "flavonol-3-O-triglucoside O-coumaroyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936659", "l": "PAPS is dephosphorylated to APS (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53450", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33194", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669854", "l": "KIT binds type II TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53941", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 => 18-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46586", "l": "1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5626549", "l": "IQGAPs bind CALM1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40543", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29657", "l": "L-cysteine(out) => L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661432", "l": "BIL binds ALB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237129", "l": "Acireductone is created (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39987", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21261", "l": "[thioredoxin]-disulfide + H2O + L-methionine => [thioredoxin]-dithiol + L-methionine (R)-S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174224", "l": "Dissociation of Cdc20 from APC/C complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004800", "l": "thyroxine 5'-deiodinase activity", "d": ["Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70765", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57802", "l": "4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite => 2,3-dinitrotoluene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008267", "l": "poly-glutamine tract binding", "d": ["Binding to a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008124", "l": "4-alpha-hydroxytetrahydrobiopterin dehydratase activity", "d": ["Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35823", "l": "5,6,7,8-tetrahydromethanopterin + NAD(+) = 7,8-dihydromethanopterin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192051", "l": "CYP7A1 7-hydroxylates CHOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.7", "l": "\"ferredoxin--NAD(P)(+) reductase (naphthalene dioxygenase ferredoxin-specific)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191303", "l": "FDPS dimer transfers IPPP to GPP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8949580", "l": "F1Fo ATP synthase dimerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48112", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46360", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}, {"i": "EC:1.14.18.4", "l": "\"phosphatidylcholine 12-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034190", "l": "apolipoprotein receptor binding", "d": ["Binding to an apolipoprotein receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48119", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69152", "l": "Removal of remaining Flap (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65952", "l": "2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-209792", "l": "N-acetylation of serotonin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199929", "l": "ERK5 activates the transcription factor MEF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166214", "l": "FA anion flip-flops to the opposite surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34182", "l": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide <=> D-glucuronate + H(+) + mycophenolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31541", "l": "(2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine => (2S)-naringenin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61271", "l": "H2O + L-2-aminohexanoate + O2 <=> 2-oxohexanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39458", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37247", "l": "H2O + thymidine 3'-phosphate = phosphate + thymidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59377", "l": "4-amino-4-deoxychorismate => 4-amino-4-deoxyprephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35037", "l": "4-aminobutanoate(out) => 4-aminobutanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24563", "l": "acetyl-CoA + L-serine <=> CoA + O-acetyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197691", "l": "WIP binds WASP,N-WASP, activating them (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008885", "l": "glutathionylspermidine synthase activity", "d": ["Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23014", "l": "a fatty acid methyl ester + S-adenosyl-L-homocysteine => a fatty acid + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73647", "l": "CTP(out) + IMP(in) = CTP(in) + IMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297333", "l": "Association of Acrosin Heavy and Light Chain (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3000433", "l": "SUMOylation of PML with SUMO3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69440", "l": "3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) = 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388817", "l": "ICOS binds ICOSL/B7-H2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611839", "l": "β3-agonists bind ADRB3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374251", "l": "DARC  is a non-specific receptor for many chemokines (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45648", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37228", "l": "(E,E)-sorbate + H(+) => (E)-1,3-pentadiene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76004", "l": "glutarate(in) + xanthurenate(out) => glutarate(out) + xanthurenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858252", "l": "HDLBP binds HDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37578", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938887", "l": "PML binds RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102939", "l": "3-methoxy-5-hydroxytoluene O-methyltransferase activity", "d": ["Catalysis of the reaction: 3-methoxy-5-hydroxytoluene + S-adenosyl-L-methionine = H+ + 3,5-dimethoxytoluene + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64780", "l": "S-benzyl-L-cysteine = 2-aminoprop-2-enoate + benzylthiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848250", "l": "ACBD6 binds LCFA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42750", "l": "5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(967) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10448", "l": "2-oxoglutarate + a flavanone + O2 = a flavone + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9860264", "l": "TASL is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865320", "l": "CBFB binds RUNX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990846", "l": "ribonucleoside-diphosphate reductase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12910", "l": "2 Fe(II)-[cytochrome] + 2 H(+) + nitrate => 2 Fe(III)-[cytochrome] + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730872", "l": "Activation of Calcineurin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29052", "l": "2 H(+)(in) + H2 + menaquinone-8 => 2 H(+)(out) + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0008796", "l": "bis(5'-nucleosyl)-tetraphosphatase activity", "d": ["Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29968", "l": "2'-deoxyuridine(in) + H(+)(in) => 2'-deoxyuridine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59446", "l": "1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2 => 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034897", "l": "4-(1-ethyl-1,4-dimethyl-pentyl)phenol monooxygenase activity", "d": ["Catalysis of the reaction: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol + O2 + 2 H+ + 2 e- = hydroquinone + 3,6-dimethylheptan-3-ol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71712", "l": "H(+)(out) + L-tyrosylglycine(out) => H(+)(in) + L-tyrosylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33899", "l": "FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose = FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": [], "t": []}, {"i": "EC:1.1.98.3", "l": "\"decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34506", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-epi-alpha-bisabolol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0052705", "l": "methylhistidine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha-methyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha-dimethyl-L-histidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392129", "l": "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35120", "l": "(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O => bisdemethoxycurcumin + CO2 + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43258", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16036", "l": "2-oxoglutarate + gibberellin A44 + O2 <=> CO2 + gibberellin A19 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14987", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57300", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32254", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) <=> (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41530", "l": "NAD(+) + octanoyl-[ACP] => (2E)-octenoyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38716", "l": "ATP + choline(out) + H2O => ADP + choline(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73970", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11139", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40734", "l": "(20S)-ginsenoside Rg3 + 2 H2O <=> (20S)-protopanaxadiol + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30523", "l": "GTP + L-glutamate + oxidized coenzyme F420-1 = GDP + H(+) + oxidized coenzyme F420-2 + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.34", "l": "\"coenzyme F420-1:gamma-L-glutamate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71484", "l": "H2O + Met-enkephalin => L-phenylalanyl-L-methionine + L-tyrosylglycylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948612", "l": "miR-19b microRNA binds CNOT6L mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14974", "l": "L-aspartate => D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74888", "l": "2',3'-cGAMP(in) + ATP + H2O => 2',3'-cGAMP(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53168", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928627", "l": "EPHB phosphorylates TIAM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50461", "l": "a medium chain fatty acid + ATP + holo-[ACP] => a medium-chain fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19050", "l": "(5R)-5-hydroxy-L-lysine + GTP => (5R)-5-phosphooxy-L-lysine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336184", "l": "GPR37L binds prosaposin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73791", "l": "dimethylallyl diphosphate + neoechinulin A = diphosphate + variecolorin G", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686430", "l": "MUS81 binds EME1, EME2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0140083", "l": "ATP-dependent protein-DNA unloader activity", "d": ["Facilitating the removal of a protein or protein complex from a DNA molecule driven by ATP hydrolysis. This can be achieved for example by introducing non-canonical DNA structures or generating torque to directly inhibit a protein-DNA binding interaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682709", "l": "LGI4 binds ADAM22,23,11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.45", "l": "\"complement factor I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67679", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14181", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.8", "l": "\"trimethyllysine dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56747", "l": "2-oxoglutarate + L-arginyl-[protein] + O2 <=> (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5604929", "l": "Activated protein C binds Protein S (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36507", "l": "docosanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetracosanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35731", "l": "sn-glycerol 3-phosphate + tetradecanoyl-CoA = 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034386", "l": "4-aminobutyrate:2-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748991", "l": "XDH oxidises 6MP to 6TU (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57520", "l": "15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11349", "l": "arsenite(in) + ATP + H2O => ADP + arsenite(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53783", "l": "beta-muricholate + lithocholoyl-CoA <=> beta-muricholoyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374909", "l": "Catabolism of Noradrenaline (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50477", "l": "anthraniloyl-CoA + L-cysteinyl-[PqsD protein] => CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71547", "l": "5-phosphomethyl-dUMP in DNA + glycine = 5-N(alpha)-glycyl-dTMP in DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949580", "l": "F1Fo ATP synthase dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036290", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to heparan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5671737", "l": "p-T774-PKN1 binds CDC25C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56516", "l": "Fe-coproporphyrin III + 2 H(+) + 2 H2O2 = 2 CO2 + 4 H2O + heme b", "d": [], "t": []}, {"i": "EC:1.3.98.5", "l": "\"hydrogen peroxide-dependent heme synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29924", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022934", "l": "GAD1 gene expression is stimulated by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14297", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose", "d": [], "t": []}, {"i": "EC:3.2.1.46", "l": "\"galactosylceramidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229181", "l": "CALM1:Ca2+ binds CNG channel (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45342", "l": "(9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+) => [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202203", "l": "Recruitment of PI3K to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0000062", "l": "fatty-acyl-CoA binding", "d": ["Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68583", "l": "ATP + H2O + L-kynurenine(out) <=> ADP + H(+) + L-kynurenine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19134", "l": "2-oxoglutarate + 3,3',5-triiodo-L-thyronine => 3,5,3'-triiodothyropyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051675", "l": "isopullulanase activity", "d": ["Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72313", "l": "glutathione(out) + taurocholate(in) => glutathione(in) + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58525", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH => (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73610", "l": "CTP(out) + dCTP(in) <=> CTP(in) + dCTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102514", "l": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose = cyanidin 3,7-di-O-beta-D-glucoside betaine + ferulate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72365", "l": "chloride(in) + hydrogencarbonate(out) => chloride(out) + hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250978", "l": "botG LC cleaves target cell VAMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430158", "l": "p-SLP-76 binds VAV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120503", "l": "medium-chain fatty acid omega-1 hydroxylase activity", "d": ["Catalysis of the reaction: an (omega-1)-ethyl medium-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23419", "l": "(2R)-O-phospho-3-sulfolactate + H2O <=> (2R)-3-sulfolactate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106358", "l": "glycerol-1-phosphate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADPH."], "t": []}, {"i": "RHEA:21416", "l": "NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429036", "l": "SLC2A9 transports Fru, Glc, urate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50762", "l": "a quinol + sulfate => a quinone + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169719", "l": "Secreted CD14 binds LPS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47528", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isocholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32416", "l": "(1S,2S,4R)-isodihydrocarveol + NAD(+) => (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34372", "l": "H2O + indole-3-acetamide => (indol-3-yl)acetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.31", "l": "\"RBR-type E3 ubiquitin transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031681", "l": "G-protein beta-subunit binding", "d": ["Binding to a G-protein beta subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936462", "l": "PIN1 mediated IRF3 degradation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19224", "l": "2 formaldehyde + H2O <=> formate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036307", "l": "23S rRNA (adenine(2030)-N(6))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(2030) in 23S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30190", "l": "(S)-dihydroorotate + a quinone <=> a quinol + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51362", "l": "(9Z)-octadecenoate + L-leucine => H2O + N-(9Z-octadecenoyl)-L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38335", "l": "(20S)-ginsenoside Rb1 + 2 H2O = (20S)-ginsenoside Rg3 + 2 D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.192", "l": "\"ginsenoside Rb1 beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102625", "l": "cirsimaritin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: cirsimaritin + S-adenosyl-L-methionine = salvigenin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14866", "l": "S-adenosyl-L-methionine + tyramine => H(+) + N-methyltyramine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25969", "l": "(S)-benzoin + NADP(+) => benzil + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134962", "l": "DHX36 binds DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047572", "l": "3-phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glycerate + H2O = D-glycerate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32681", "l": "(2E)-geraniol + diphosphate => (2E)-geranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-844438", "l": "NLRP1 oligomerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36210", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22516", "l": "ATP + taurocyamine = ADP + H(+) + N-phosphotaurocyamine", "d": [], "t": []}, {"i": "EC:2.7.3.4", "l": "\"taurocyamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009309", "l": "RUNX2 binds STUB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004961", "l": "thromboxane A2 receptor activity", "d": ["Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40922", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55440", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102606", "l": "octat-9-en-7-ol 5-monooxygenase activity", "d": ["Catalysis of the reaction: cyclooctat-9-en-7-ol + O2 + NADPH + H+ = cyclooctat-9-en-5,7-diol + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853496", "l": "SCF:FBXL7 binds AURKA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44245", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0004950", "l": "chemokine receptor activity", "d": ["Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76738", "l": "decane + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-decanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47162", "l": "3-dehydro-4-methylzymosterol + CO2 + NADH => 4beta-methylzymosterol-4alpha-carboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004921", "l": "interleukin-11 receptor activity", "d": ["Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.3", "l": "\"protein-synthesizing GTPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862300", "l": "LYZ binds bacterial peptidoglycan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674529", "l": "AAMP binds to TBXA2R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38977", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28949", "l": "H(+)(in) + L-arabinose(out) => H(+)(out) + L-arabinose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17432", "l": "NAD(+) + trans-4-hydroxycyclohexanecarboxylate <=> 4-oxocyclohexanecarboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34974", "l": "Fe(3+)(in) <=> Fe(3+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72791", "l": "(4E,15E)-bilirubin IXalpha C8-beta-D-glucuronoside(out) = (4E,15E)-bilirubin IXalpha C8-beta-D-glucuronoside(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72810", "l": "L-histidine(out) <=> L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173705", "l": "C5b binds C6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49080", "l": "dibenzothiophene 5-oxide + FMNH2 + O2 = dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27864", "l": "guanosine + phosphate => 3'-GMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11415", "l": "6-hydroxymethyl-7,8-dihydropterin + ATP <=> (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2328037", "l": "Fibrillin-1 binds integrins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034573", "l": "didemethylisoproturon amidohydrolase activity", "d": ["Catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71527", "l": "thymine(out) = thymine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030172", "l": "troponin C binding", "d": ["Binding to troponin C, the calcium-binding subunit of the troponin complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867344", "l": "OMA1 hydrolyses OPA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45760", "l": "dTDP-beta-L-daunosamine + epsilon-rhodomycinone = dTDP + H(+) + rhodomycin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666001", "l": "Profilin:G-actin binds MKL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65664", "l": "citrate(out) + 4 Na(+)(out) = citrate(in) + 4 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42281", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31897", "l": "alpha-humulene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58620", "l": "N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64034", "l": "a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.304", "l": "\"poly[(R)-3-hydroxyalkanoate] polymerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48365", "l": "beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer + GDP-beta-L-fucose => beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36182", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39885", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH => dTDP-6-deoxy-alpha-D-allose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51167", "l": "cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0016869", "l": "intramolecular aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from one position to another within a single molecule."], "t": []}, {"i": "EC:5.4.3.-", "l": "\"Transferring amino groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793591", "l": "LIAS synthesizes lipoyl-GCSH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41853", "l": "H(+) + malonyl-[ACP] + octanoyl-[ACP] => 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170986", "l": "Ral-GDS binds to Ras-GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050538", "l": "N-carbamoyl-L-amino-acid hydrolase activity", "d": ["Catalysis of the reaction: N-carbamoyl-L-2-amino acid + H2O = L-2-amino acid + NH3 + CO2. The N-carbamoyl-L-2-amino acid is a 2-ureido carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029454", "l": "Autophosphorylation of PAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870703", "l": "SOD2 (MnSOD) gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38224", "l": "(9Z)-octadecenoyl-CoA + decan-1-ol => 1-O-decyl-(9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56249", "l": "1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55398", "l": "(3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine => (R)-carnitine + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172666", "l": "RB1 binds condensin II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140770", "l": "CoA-dependent peptidyl-lysine N6-myristoyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H+ + N(6)-tetradecanoyl-L-lysyl-[protein]."], "t": []}, {"i": "RHEA:59752", "l": "L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77776", "l": "acetyl-CoA + N(6)-methyl-L-lysyl-[histone] => CoA + H(+) + N(6)-acetyl-N(6)-methyl-L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42965", "l": "uridine(54/55) in tRNA => pseudouridine(54/55) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446634", "l": "IRAK4 is activated by autophosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678981", "l": "TLR9 processing at neutral pH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15829", "l": "a 16alpha-hydroxysteroid = a 16beta-hydroxysteroid", "d": [], "t": []}, {"i": "EC:5.1.99.2", "l": "\"16-hydroxysteroid epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62480", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010815", "l": "SLITs bind keratan sulfate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158849", "l": "Phenol can form a sulfate conjugate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14320", "l": "morphine + NAD(+) <=> H(+) + morphinone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196417", "l": "Reduction of desmosterol to cholesterol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668714", "l": "RAC1:GTP binds NOX1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050129", "l": "N-formylglutamate deformylase activity", "d": ["Catalysis of the reaction: N-formyl-L-glutamate + H2O = L-glutamate + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28881", "l": "H(+)(out) + L-tryptophan(out) => H(+)(in) + L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4167511", "l": "HLCS biotinylates ACACB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14389", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.149", "l": "\"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948757", "l": "AKT phosphorylates MKRN1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9909159", "l": "HK1 phosphorylates Mannose to Man6P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52519", "l": "trans-4-hydroxy-L-proline + ubiquinone-10 <=> (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42236", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950782", "l": "p-STAT1 binds p-STAT3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77589", "l": "Recognition of AAUAAA sequence by CPSF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11471", "l": "(S)-3-methyl-2-oxopentanoate + L-valine <=> 3-methyl-2-oxobutanoate + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20119", "l": "ADP + H(+) + L-rhamnulose 1-phosphate => ATP + L-rhamnulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20191", "l": "H(+) + NADH + uracil => 5,6-dihydrouracil + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74863", "l": "(R)-salsolinol + S-adenosyl-L-methionine = H(+) + N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9615348", "l": "AGT(34-41) binds to AGTR2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0033731", "l": "arogenate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33132", "l": "L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate => 3-phenylpyruvate + tetrahydrotyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32185", "l": "cholest-5-en-3-one + H2O2 => cholesterol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35358", "l": "3-hydroxyisopentadecanoyl-CoA <=> (2E)-13-methyltetradecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140382", "l": "tryptamine 4-monooxygenase activity", "d": ["Catalysis of the reaction: tryptamine + reduced acceptor + O2 = 4-hydroxytryptamine + acceptor + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730843", "l": "Phosphorylation of LAT by p-SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549304", "l": "OCT3 mediates renal clearance of organic cations (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77906", "l": "2 Fe(III)-[cytochrome c] + succinate <=> 2 Fe(II)-[cytochrome c] + fumarate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63385", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72743", "l": "leukotriene C4(out) = leukotriene C4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17561", "l": "acetylcholine + H2O = acetate + choline + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.7", "l": "\"acetylcholinesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40087", "l": "22-hydroxydocosanoate + NAD(+) = 22-oxodocosanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109639", "l": "Formation of the closed pre-initiation complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50180", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15213", "l": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = CoA + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2]", "d": [], "t": []}, {"i": "EC:2.3.1.61", "l": "\"dihydrolipoyllysine-residue succinyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10818", "l": "L-fucose + methyl beta-D-galactoside => H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48137", "l": "a ganglioside GM3 + H2O => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10601", "l": "prostaglandin H2 => prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211206", "l": "Translocation of DFF to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836275", "l": "TFAP2A binds TFAP2B (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264615", "l": "Loading of acetylcholine in synaptic vesicles (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34176", "l": "2-hydroxybenzoyl-CoA + malonyl-CoA => 4-hydroxycoumarin + CO2 + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.25", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687465", "l": "MRN complex binds RBBP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42910", "l": "5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1939) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.293", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35027", "l": "ATP + H2O + tungstate(in) = ADP + H(+) + phosphate + tungstate(out)", "d": [], "t": []}, {"i": "EC:7.3.2.6", "l": "\"ABC-type tungstate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55560", "l": "a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445448", "l": "HHIP binds Hedgehog (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73266", "l": "genkwanin + S-adenosyl-L-methionine <=> apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939938", "l": "ESRRA:PPARG1CB binds the RUNX2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13621", "l": "4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose", "d": [], "t": []}, {"i": "EC:5.4.99.15", "l": "\"(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63079", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 2-acetylphloroglucinol + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21020", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.5", "l": "\"chorismate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444171", "l": "Receptor FFAR2 binds carboxylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2214324", "l": "Collagen type VII dimerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0052886", "l": "9,9'-dicis-carotene:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: 9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605797", "l": "SMPD1 hydrolyzes SPHM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030408", "l": "glycine formimidoyltransferase activity", "d": ["Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855047", "l": "Hydrolysis of internal thioester in C4b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43910", "l": "D-galactose + sphing-4-enine => beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66568", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = preluffariellolide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109813", "l": "GRB2-1 binds SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420265", "l": "AMY1-3 bind IAPP(34-70) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088134", "l": "PLK1 phosphorylates FOXM1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73928", "l": "griseophenone D + S-adenosyl-L-methionine => griseophenone C + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388605", "l": "POMC(138-176) binds MC2R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30473", "l": "(1S,5S,6S)-alpha-bergamotene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20766", "l": "oxaloacetate + propanoyl-CoA => (S)-methylmalonyl-CoA + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0140767", "l": "enzyme-substrate adaptor activity", "d": ["An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72176", "l": "5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) => 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417842", "l": "P2Y10 receptor can bind to LPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023027", "l": "MHC class I protein binding, via antigen binding groove", "d": ["Binding to a major histocompatibility complex class I molecules via the antigen binding groove."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450088", "l": "GLUT1 tetramer binds 4xATP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26306", "l": "2-aminophenol + O2 => 2-aminomuconate 6-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62384", "l": "cyclic (2R)-2,3-bisphosphoglycerate + H2O = (2R)-2,3-bisphosphoglycerate + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.61", "l": "\"cyclic 2,3-diphosphoglycerate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951676", "l": "RUNX3 binds TEADs and YAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49485", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68603", "l": "ORC5 binds ORC2:ORC3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53294", "l": "H(+) + N-carbamoyl-L-methionine => H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840949", "l": "ARSA removes sulfate from SM3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2106614", "l": "Duplex miRNA is loaded into Argonaute (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22945", "l": "3beta-hydroxy-5beta-pregnane-20-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12112", "l": "indole-3-pyruvate + S-adenosyl-L-methionine = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.47", "l": "\"indolepyruvate C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9035227", "l": "TXN2 binds CysS248-MPST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374663", "l": "DCC interaction with Ezrin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65351", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA <=> 3-oxochol-4,6-dien-24-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66104", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61357", "l": "ATP + H2O + methotrexate(in) => ADP + H(+) + methotrexate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53016", "l": "chlorohydroquinone + 2 glutathione = chloride + glutathione disulfide + H(+) + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953111", "l": "E2F6 binds TFDP1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56338", "l": "ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61809", "l": "holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP => AMP + H(+) + L-alanyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56827", "l": "AH2 + cyclooctat-9-ene-5,7-diol + O2 <=> A + cyclooctatin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22324", "l": "H2O + leukotriene A4 = leukotriene B4", "d": [], "t": []}, {"i": "EC:3.3.2.6", "l": "\"leukotriene-A4 hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14612", "l": "D-sorbitol + NADP(+) <=> H(+) + keto-L-sorbose + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25399", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate", "d": [], "t": []}, {"i": "EC:5.4.4.6", "l": "\"9,12-octadecadienoate 8-hydroperoxide 8S-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18320", "l": "an L-alpha-amino acid <=> a D-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799761", "l": "TP53 binds PPP1R13L (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49793", "l": "eicosanoyl-CoA + glycine => CoA + H(+) + N-eicosanoylglycinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10729", "l": "GDP-6-deoxy-alpha-D-talose + NAD(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31525", "l": "3 CO2 + ethene + H2O => 2-oxoglutarate + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817513", "l": "AICDA deaminates cytidine in chromatin containing histone H3.3 and 5-methylcytidine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33467", "l": "5-dehydroepisterol + H(+) + NADPH + O2 = ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676599", "l": "sBAFF trimer binds BAFFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33898", "l": "NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose <=> H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033904", "l": "dextranase activity", "d": ["Catalysis of the endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40937", "l": "1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+) => a 1-acylglycerone 3-phosphate + hexadecan-1-ol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944246", "l": "Association of procollagen type XXI (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848250", "l": "ACBD6 binds LCFA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12418", "l": "acryloyl-CoA + NH4(+) => beta-alanyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38467", "l": "a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686071", "l": "GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-481044", "l": "Surface deployment of platelet alpha granule membrane components (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797100", "l": "CCNK binds CDK13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68801", "l": "H2O + nigerose => alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79070", "l": "(4Z,15Z)-bilirubin IXalpha + UDP-alpha-D-glucuronate <=> (4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67012", "l": "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.50", "l": "\"mRNA guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2172678", "l": "PHF8 demethylates histone H4K20me1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44747", "l": "4 H(+) + 4 malonyl-CoA <=> (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24634", "l": "5 H(+) + 3 NADPH + nitrite => 2 H2O + 3 NADP(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72103", "l": "Formation of pre-mRNPs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78914", "l": "a very-long-chain (3S)-hydroxyacyl-CoA <=> a very-long-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24001", "l": "a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] => a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40295", "l": "ATP + CoA + hexadecanedioate = AMP + diphosphate + hexadecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12624", "l": "H(+) + L-aspartate <=> CO2 + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71650", "l": "a medium-chain (3S)-3-hydroxyacyl-CoA <=> a medium-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49983", "l": "H2O + hexanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43278", "l": "a ganglioside GalNAc-GD1a + H(+) + UDP => a ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76817", "l": "H(+) + NADH + NH4(+) + pyruvate => D-alanine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21742", "l": "[thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate => 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65139", "l": "(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78794", "l": "D-cysteine + H2O + O2 <=> 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9866132", "l": "Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70514", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15192", "l": "2 Fe(III)-[cytochrome c553] + formate <=> CO2 + 2 Fe(II)-[cytochrome c553] + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030763", "l": "isobutyraldoxime O-methyltransferase activity", "d": ["Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428609", "l": "Type I Na+-coupled phosphate co-transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050140", "l": "nitrate reductase (cytochrome) activity", "d": ["Catalysis of the reaction: ferrocytochrome + nitrate = ferricytochrome + nitrite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33387", "l": "cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine = aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49767", "l": "ethylenediaminetriacetate + FMNH2 + O2 <=> ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.47", "l": "\"(S)-hydroxynitrile lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62753", "l": "H2O + pravastatin lactone => (S)-2-methylbutanoate + H(+) + pravastatin diol lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047162", "l": "17-O-deacetylvindoline O-acetyltransferase activity", "d": ["Catalysis of the reaction: (1R,9R,10S,11R,12R,19R)-12-ethyl-10,11-dihydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + acetyl-CoA = (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48238", "l": "1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+) => 2 2-acetylphloroglucinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70980", "l": "4-aminobutanoate(out) + n H(+)(in) => 4-aminobutanoate(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72684", "l": "cholate(out) => cholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32431", "l": "(1R,4S)-menthone + H(+) + NADPH + O2 = (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39943", "l": "a 1-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64376", "l": "8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32577", "l": "(1R,5R)-alpha-pinene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031847", "l": "type 1 neurotensin receptor binding", "d": ["Binding to a type 1 neurotensin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74723", "l": "Endosome acidification (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50059", "l": "ATP + glycocholate(in) + H2O <=> ADP + glycocholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56276", "l": "ATP + L-proline = 3'-L-prolyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39440", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA => (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39547", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA = (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71804", "l": "acetate(out) + H(+)(out) => acetate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74707", "l": "Binding of IRS to insulin receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0097200", "l": "cysteine-type endopeptidase activity involved in execution phase of apoptosis", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52380", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809140", "l": "IL35 binds IL-12RB2:IL6ST receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433451", "l": "JAK2 binds to p-KIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57165", "l": "2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 => (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106162", "l": "mRNA N-acetyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H+ + phosphate."], "t": []}, {"i": "RHEA:58480", "l": "a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.112", "l": "\"site-1 protease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70986", "l": "glycine(out) + n H(+)(in) <=> glycine(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62918", "l": "an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine => an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46146", "l": "(24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709098", "l": "DHFR dimer reduces FOLA to DHF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052825", "l": "inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate."], "t": []}, {"i": "REACT:R-HSA-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45622", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-butanoyl ethanolamine => H2O + N-butanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247837", "l": "WNT ligands traffic to the Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17722", "l": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73394", "l": "H(+)(in) + phosphate(in) + sulfate(out) <=> H(+)(out) + phosphate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168982", "l": "Collagen type XVI degradation by MMP9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659879", "l": "Defective SI does not hydrolyze iMal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015187", "l": "glycine transmembrane transporter activity", "d": ["Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001616", "l": "growth hormone secretagogue receptor activity", "d": ["Combining with ghrelin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22819", "l": "alpha-D-xylose <=> alpha-D-xylulofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798257", "l": "PTPRS binds NTRK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675473", "l": "SH2B binds JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32813", "l": "benzoate(out) => benzoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429767", "l": "Passive I- efflux mediated by SLC5A8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67188", "l": "ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out) = ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53881", "l": "ADP-alpha-D-glucose + D-glucose 6-phosphate => ADP + alpha,alpha-trehalose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64091", "l": "acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA <=> 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73379", "l": "(R)-lipoate(out) + 2 Na(+)(out) = (R)-lipoate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35585", "l": "D-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27408", "l": "a ubiquinone + H2O + pyruvate <=> a ubiquinol + acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109701", "l": "PDPK1 binds PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59648", "l": "D-xylotriono-1,5-lactone + H2O = D-xylotrionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23145", "l": "H2O + N-acetyl-alpha-D-glucosamine + NAD(+) => 2 H(+) + N-acetyl-D-glucosaminate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140806", "l": "SERPINC1 binds SERPINC1 activators (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1454916", "l": "The ABCC family mediates organic anion transport (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690152", "l": "USP5 cleaves polyubiquitin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730902", "l": "Oligomerization of p-CARMA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69957", "l": "Ca(2+)(out) + 3 Na(+)(in) => Ca(2+)(in) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28978", "l": "H(+)(out) + L-asparagine(in) <=> H(+)(in) + L-asparagine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65508", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 = H2O2 + NH4(+) + pre-mycofactocin", "d": [], "t": []}, {"i": "EC:1.4.3.26", "l": "\"pre-mycofactocin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29342", "l": "(S)-malate(in) + 2 H(+)(in) <=> (S)-malate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73430", "l": "genkwanin + O2 + reduced [NADPH--hemoprotein reductase] <=> H2O + oxidized [NADPH--hemoprotein reductase] + scutellarein 7-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757097", "l": "SARS-CoV-2 N binds NLRP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43779", "l": "an N-(acyl)-sphingosylphosphocholine(in) <=> an N-(acyl)-sphingosylphosphocholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676599", "l": "sBAFF trimer binds BAFFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78078", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.246", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132133", "l": "C5b:C6:C7 inserts into the target cell membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619125", "l": "CaMKK phosphorylates CAMK4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-996755", "l": "ZFPM proteins bind GATA proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814764", "l": "Plasma membrane resorption (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392513", "l": "Rap1 signal termination by Rap1GAPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57080", "l": "glutathione + S-methyl-1-thio-D-xylulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione", "d": [], "t": []}, {"i": "EC:2.8.4.6", "l": "\"S-methyl-1-thioxylulose 5-phosphate methylthiotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036104", "l": "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BMG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784765", "l": "p-Y705-STAT3 dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41478", "l": "CoA + zymosterol ester => an acyl-CoA + zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15510", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47020", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O = [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65403", "l": "butan-1-ol + butanoyl-CoA <=> butyl butanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.95", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61087", "l": "(2S)-naringenin + 2-oxoglutarate + O2 <=> (2R,3R)-dihydrokaempferol + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199456", "l": "PTEN dephosphorylates PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61136", "l": "(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + quercetin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674015", "l": "Olaratumab binds PDGFRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52515", "l": "a quinone + trans-4-hydroxy-L-proline <=> (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420265", "l": "AMY1-3 bind IAPP(34-70) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49761", "l": "EDTA + FMNH2 + O2 => ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675656", "l": "EDA:EDAR binds EDARADD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76647", "l": "(3S)-3-hydroxyadipyl-CoA = (E)-2,3-didehydroadipoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53388", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate = 5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879909", "l": "Activation of STAT5a/b by JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102656", "l": "1-18:2-2-trans-16:1-phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070540", "l": "stearic acid binding", "d": ["Binding to stearic acid, the 18-carbon saturated fatty acid octadecanoic acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30945", "l": "(2E)-octenoyl-CoA + FADH2 => FAD + H(+) + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53061", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate => estrone 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69068", "l": "RFC dissociates after sliding clamp formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36823", "l": "1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol = CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate", "d": [], "t": []}, {"i": "EC:2.7.8.39", "l": "\"archaetidylinositol phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800380", "l": "PTPRD binds IL1RAP-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23895", "l": "3-nitropropanoate + NADP(+) <=> 3-nitroacrylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67147", "l": "2-oxoglutarate + jasmonate + O2 <=> (1R,2R)-12-hydroxyjasmonate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034323", "l": "O-butanoyltransferase activity", "d": ["Catalysis of the transfer of a butyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050506", "l": "vomilenine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-glucose + vomilenine = H+ + raucaffricine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093327", "l": "EPHA binds TIAM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5695964", "l": "ABHD14B hydrolyses PNPB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67697", "l": "H2O + hexadecanedioyl-CoA => CoA + H(+) + hexadecanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005144", "l": "interleukin-13 receptor binding", "d": ["Binding to an interleukin-13 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41951", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176445", "l": "SMURF2 binds SMAD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48459", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O <=> 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624948", "l": "KIF17 enters the cilium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30884", "l": "D-glucurono-3,6-lactone + 2 H2O + NAD(+) => D-glucarate + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446322", "l": "PARVA associates with Paxillin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848939", "l": "PTK6 binds KHDRBS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106158", "l": "glycero-3-phosphocholine acyltransferase activity", "d": ["Catalysis of the reaction:acyl-CoA + glycerophosphocholine = CoA + 1-acyl-sn-glycero-3-phosphocholine."], "t": []}, {"i": "RHEA:58476", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0010853", "l": "cyclase activator activity", "d": ["Binds to and increases the activity of an enzyme that catalyzes a ring closure reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47881", "l": "dioctanoylglycerol + H2O => H(+) + octanoate + octanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706837", "l": "AR binds AR antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10620", "l": "(E)-cinnamaldehyde + CoA + NADP(+) = (E)-cinnamoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42708", "l": "guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.33", "l": "\"tRNA (guanine(46)-N(7))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23393", "l": "(n-1) H2O + RNA(n) => n a ribonucleoside 5'-phosphate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196857", "l": "PANK2 phosphorylates PanK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.120", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34111", "l": "carboxyspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680262", "l": "SARS coronavirus gRNA:RTC:RNA primer binds RTC inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61432", "l": "(R)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.123", "l": "\"7-epi-iridoid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350769", "l": "trans-Golgi Network Coat Activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031419", "l": "cobalamin binding", "d": ["Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483174", "l": "PE is methylated to PC by PEMT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0044183", "l": "protein folding chaperone", "d": ["Binding to a protein or a protein-containing complex to assist the protein folding process."], "t": []}, {"i": "REACT:R-HSA-9018785", "l": "RHOBTB2 binds GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912727", "l": "CBL binds VAV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69005", "l": "Cdc6 protein is phosphorylated by CDK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58223", "l": "L-lysyl-[protein] + NAD(+) <=> H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034524", "l": "2-hydroxyisophthalate decarboxylase activity", "d": ["Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15186", "l": "L-arginine + succinyl-CoA => CoA + H(+) + N(2)-succinyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791158", "l": "Expression of CXXC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73338", "l": "ATP + beta-alanine + tryptamine <=> AMP + beta-alanyl-tryptamine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034819", "l": "3-HSA hydroxylase activity", "d": ["Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADPH + H+ + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57888", "l": "a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44266", "l": "4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA => eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56916", "l": "3beta-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11807", "l": "an aromatic aldehyde + H2O + NAD(+) <=> an aromatic carboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46333", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10826", "l": "H(+) + NADPH + oxaloacetate => (S)-malate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40991", "l": "(E)-4-coumaroyl-CoA + H2O = 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.272643194726172", "identifiers": [{"i": "GO:0004520", "l": "DNA endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75854", "l": "all-trans-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27301", "l": "2-formylbenzoate + H2O + NAD(+) <=> 2 H(+) + NADH + phthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78552", "l": "Li(+)(in) => Li(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683635", "l": "E pentamer is transported to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36154", "l": "(E)-cinnamyl alcohol + acetyl-CoA <=> (E)-cinnamyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018471", "l": "4-chlorobenzaldehyde oxidase activity", "d": ["Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605624", "l": "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15982", "l": "H(+) + S-adenosyl-L-methionine => CO2 + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005332", "l": "gamma-aminobutyric acid:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653596", "l": "Defective SLC35C1 does not transport UDP-Fuc from cytosol to Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65867", "l": "5alpha-androst-1-ene-3,17-dione + A + H2O <=> 5alpha-androstan-1,3,17-trione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692539", "l": "HRH1 binds HRH1 inverse agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17435", "l": "AH2 + betaine aldehyde => A + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36166", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate <=> ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76477", "l": "H2O2 + hexadecanal => hexadecan-1-ol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52052", "l": "9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9620103", "l": "ALDH2 transforms GTN to NO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77785", "l": "2-dehydro-D-glucose + glycine + H2O2 => H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)glycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707659", "l": "Hemes:LY96 activates TLR4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692880", "l": "HRH3 binds Hist (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30219", "l": "dimethyl sulfoxide + H2O + NAD(+) = dimethyl sulfone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.8.1.17", "l": "\"dimethylsulfone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430158", "l": "p-SLP-76 binds VAV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008390", "l": "testosterone 16-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: testosterone + donor-H2 + O2 = 16-alpha-hydroxytestosterone + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254251", "l": "ERBB4s80 binds YAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48763", "l": "L-threitol + NAD(+) <=> H(+) + L-erythrulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43015", "l": "L-homocysteine <=> 2-aminobut-2-enoate + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.943982515046912", "identifiers": [{"i": "GO:0046915", "l": "transition metal ion transmembrane transporter activity", "d": ["Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43257", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58562", "l": "15alpha-stemmadenine intermediate I + NADPH => 15alpha-stemmadenine intermediate II + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56123", "l": "2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433955", "l": "Phosphorylation of IKKs complex by activated TAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39418", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH <=> (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21957", "l": "UDP-alpha-D-glucose + vitexin => H(+) + UDP + vitexin 2''-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41294", "l": "H2O + N-dodecanoylsphing-4-enine <=> dodecanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640063", "l": "Ca2+ binds KCNIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38613", "l": "cyclic ADP-beta-D-ribose + H(+) + nicotinamide => NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36338", "l": "D-glucuronate + H2O + NAD(+) <=> D-glucarate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64435", "l": "H(+)(out) + L-alanyl-L-prolylglycine(out) <=> H(+)(in) + L-alanyl-L-prolylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18778", "l": "an alkylmercury + H(+) => an alkane + Hg(2+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201717", "l": "CSNK2-mediated phosphorylation of DVL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358789", "l": "Self-ubiquitination of RNF41 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112342", "l": "Inactivation of MAP2K1 by CDK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170045", "l": "isopentenyl pyrophosphate transmembrate transporter activity", "d": ["Enables the transfer of isopentenyl pyrophosphate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52730", "l": "a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37112", "l": "(15Z)-tetracosenoyl-CoA + sphing-4-enine => CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38586", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58643", "l": "a 5'-end 5'-phospho-ribonucleoside-RNA + 2 S-adenosyl-L-methionine <=> a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70830", "l": "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51417", "l": "a (2S,3R)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55402", "l": "archaeosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66238", "l": "H2O2 + IC-asc-DeltaC9-CoA => IC-asc-C9-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54654", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => peregrinol diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10738", "l": "an aldehyde + H(+) + NADH => a primary alcohol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25528", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.86", "l": "\"phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15176", "l": "H(+) + H2O2 + NADPH <=> 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34072", "l": "trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824981", "l": "MITF-M and the SWI/SNF complex bind the TYR promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67405", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45807", "l": "ATP + hydroxylamine + L-glutamate <=> ADP + L-glutamine hydroxamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610726", "l": "The IFT-A complex recruits TULP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41864", "l": "(2E)-decenoyl-[ACP] + H(+) + NADPH = decanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16141", "l": "2'-deoxymugineate + NAD(+) = 3''-deamino-3''-oxonicotianamine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33436", "l": "fecosterol => episterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20427", "l": "(S)-oxalosuccinate + ADP + H(+) + phosphate => 2-oxoglutarate + ATP + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51210", "l": "12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH => 20-hydroxy-leukotriene B4 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047416", "l": "arylalkyl acylamidase activity", "d": ["Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982017", "l": "Active G alpha (q) binds RGS proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030060", "l": "L-malate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30486", "l": "N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61096", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13205", "l": "a monosaccharide 1-phosphate + H(+) + UTP = a UDP-monosaccharide + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.64", "l": "\"UTP-monosaccharide-1-phosphate uridylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30071", "l": "acetyl-CoA + butanoate = acetate + butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0015391", "l": "nucleobase:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848339", "l": "PNPLA5 hydrolyzes TAG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130194", "l": "ABL phosphorylates WAVEs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44320", "l": "1-decanoylglycerol + H2O = decanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082391", "l": "Trimerization of HSF1 in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37154", "l": "(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate <=> 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35093", "l": "2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine => anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17823", "l": "3-cyano-L-alanine + H(+) + hydrogen sulfide => hydrogen cyanide + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73459", "l": "5 H(+) + 2 O2 + protochlorophyllide a + 4 reduced [2Fe-2S]-[ferredoxin] = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48628", "l": "a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17812", "l": "Mg-protoporphyrin IX + S-adenosyl-L-methionine <=> Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25642", "l": "(1R,4S)-menthone + NADP(+) => (R)-pulegone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74277", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A => a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24572", "l": "[(1->4)-alpha-D-glucosyl](n) + sucrose = [(1->4)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}, {"i": "EC:2.4.1.4", "l": "\"amylosucrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990648", "l": "inositol-4,5,6-triphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 4,5,6-trisphosphate + H2O = 1D-myo-inositol 4,6-bisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37990", "l": "delta-tocopherol <=> 2-methyl-6-phytyl-1,4-benzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950225", "l": "Expression of Ras-related protein Rap-1b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53285", "l": "NAD(+) + scyllo-inosose => 3-dehydro-scyllo-inosose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.14", "l": "\"(Kdo)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129353", "l": "Tropoelastin associates with microfibrils (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046998", "l": "(S)-usnate reductase activity", "d": ["Catalysis of the reaction: (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD+ = (S)-usnate + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3204303", "l": "MRE11 binds cytosolic DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42732", "l": "guanosine(527) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.170", "l": "\"16S rRNA (guanine(527)-N(7))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36555", "l": "eicosanoyl-CoA + sphinganine = CoA + H(+) + N-eicosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24701", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) <=> 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917700", "l": "MVB Vesicle Formation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797803", "l": "PTPRD binds SLITRK1-6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047051", "l": "D-lactate dehydrogenase (cytochrome c-553) activity", "d": ["Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c553] = 2 [Fe(II)cytochrome c553] + 2 H+ + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688797", "l": "ATXN3 family cleave Ub chains (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43379", "l": "5'-deoxyinosine + phosphate <=> 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19807", "l": "a purine nucleobase + alpha-D-ribose 1-phosphate => a purine D-ribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26379", "l": "cyclic pyranopterin phosphate + diphosphate => GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78844", "l": "a fatty acid(in) + ATP + H2O => a fatty acid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73803", "l": "dimethylallyl diphosphate + neoechinulin B = diphosphate + isoechinulin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42448", "l": "(R)-2-hydroxyglutaryl-CoA = (2E)-glutaconyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.167", "l": "\"(R)-2-hydroxyglutaryl-CoA dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73466", "l": "carcinine + H2O <=> beta-alanine + histamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71621", "l": "(S)-malate(out) + 2 thiosulfate(in) => (S)-malate(in) + 2 thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36765", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13895", "l": "ADP + AMP + 2 H(+) => H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30763", "l": "H2O + L-valine + NAD(+) = 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.1.23", "l": "\"valine dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66795", "l": "N-methyl-D-dopa + O2 <=> (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9854368", "l": "ROS,RNS oxidize ACO2:4Fe-4S (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35871", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33976", "l": "DIMBOA beta-D-glucoside + H2O => D-glucose + DIMBOA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851102", "l": "NPM1-ALK- and PI3K-dependent MDM2 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193650", "l": "p75NTR binds to NADE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31900", "l": "indole + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67279", "l": "H2O + hexanal + NAD(+) <=> 2 H(+) + hexanoate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71163", "l": "HPD dioxygenates HPP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66673", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) => 5,7-dihydroxy-4-methylphthalide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77059", "l": "3-methylcyclopentanamine + H2O + NADP(+) = 3-methylcyclopentanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61098", "l": "(S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388808", "l": "CD28 homodimer binds B7-2 monomer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26482", "l": "adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA", "d": [], "t": []}, {"i": "EC:2.5.1.75", "l": "\"tRNA dimethylallyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6804100", "l": "HMGB1 binds LPS (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9611721", "l": "β1-agonists bind ADRB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15451", "l": "4-maleylacetoacetate + H(+) => homogentisate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46561", "l": "episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004463", "l": "leukotriene-A4 hydrolase activity", "d": ["Catalysis of the reaction: H2O + leukotriene A(4) = leukotriene B(4)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28501", "l": "formaldehyde + mycothiol <=> S-(hydroxymethyl)mycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69802", "l": "D-tryptophanyl-tRNA(Trp) + H2O <=> D-tryptophan + tRNA(Trp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64444", "l": "L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.368", "l": "\"[histone H3]-lysine(9) N-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757688", "l": "SERPINA6 binds PREDN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24178", "l": "[ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] => [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.13", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76464", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + A => 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60735", "l": "H2O + NADP(+) + perillyl aldehyde <=> 2 H(+) + NADPH + perillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102376", "l": "lupeol 28-oxidase activity", "d": ["Catalysis of the reaction: lupeol + 3 NADPH + 3 O2 + 3 H+ = betulinic acid + 3 NADP + 4 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050640", "l": "isopenicillin-N N-acyltransferase activity", "d": ["Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66563", "l": "(R)-noradrenaline + L-glutaminyl-[protein] <=> 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416562", "l": "p190RhoGAP binds Plexin-B1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9825751", "l": "HINT1 binds MITF-M (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707516", "l": "FeHM dissociates from MetHb (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15813", "l": "1H-imidazole + acetyl-CoA = CoA + N-acetylimidazole", "d": [], "t": []}, {"i": "EC:2.3.1.2", "l": "\"imidazole N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61318", "l": "germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264848", "l": "apoA-I binds to CUBN:AMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20397", "l": "L-cysteine + O-succinyl-L-homoserine = H(+) + L,L-cystathionine + succinate", "d": [], "t": []}, {"i": "EC:2.5.1.48", "l": "\"cystathionine gamma-synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14893", "l": "D-ornithine = (2R,4S)-2,4-diaminopentanoate", "d": [], "t": []}, {"i": "EC:5.4.3.5", "l": "\"D-ornithine 4,5-aminomutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246509", "l": "botC:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030377", "l": "urokinase plasminogen activator receptor activity", "d": ["Combining with the urokinase plasminogen activator to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62021", "l": "H2O + sitosteryl 3-beta-D-glucoside => D-glucose + sitosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46863", "l": "3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate <=> 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090704", "l": "nicotinate-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: nicotinate + UDP-D-glucose = O-D-glucosylnicotinate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38113", "l": "H(+) + L-glyceraldehyde + NADPH => glycerol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098697", "l": "ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels", "d": ["Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39089", "l": "(2E)-decenedioyl-CoA + H2O2 => decanedioyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247844", "l": "WNT ligands traffic to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32971", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391942", "l": "IP receptor can bind prostacyclin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46712", "l": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22501", "l": "(E)-feruloyl-CoA + H(+) + malonyl-CoA => (E)-feruloylacetyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13234", "l": "guanosine + phosphate => alpha-D-ribose 1-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17845", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.193", "l": "\"5-amino-6-(5-phosphoribosylamino)uracil reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30684", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-D-mannosamine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48027", "l": "1,2,3-tripropanoylglycerol + H2O <=> dipropanoylglycerol + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706350", "l": "FLT3 phosphorylates CBL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0015616", "l": "DNA translocase activity", "d": ["Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37470", "l": "1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP + H(+) <=> 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25924", "l": "A + H2O + quinolin-8-ol = 8-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754129", "l": "CDK6 inhibitors bind CDK6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69005", "l": "Cdc6 protein is phosphorylated by CDK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68755", "l": "alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] <=> alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618328", "l": "ATAT acetylates microtubules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682598", "l": "ATM phosphorylates HERC2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604328", "l": "AKT1 phosphorylates NOTCH4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43875", "l": "3-oxochol-4-en-22-oate + ATP + CoA <=> 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388809", "l": "CTLA-4 binds B7-1/B7-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.2.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60115", "l": "(R)-3-(indol-3-yl)lactoyl-CoA <=> (E)-3-(indol-3-yl)acryloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14190", "l": "D-tryptophan + O2 => N-formyl-D-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20520", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218824", "l": "p-6Y-VEGFR2 binds FYN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70501", "l": "PC carboxylates PYR to OA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71716", "l": "H(+)(out) + L-leucyl-L-leucine(out) => H(+)(in) + L-leucyl-L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.46", "l": "\"adamalysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52166", "l": "(R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52468", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59969", "l": "L-threonyl-[protein] + octanoyl-CoA => CoA + O-octanoyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654511", "l": "FGFRL1 dimer binds FGFs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70060", "l": "a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58426", "l": "(E)-hex-2-enal + H(+) + NADPH => (E)-hex-2-en-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36739", "l": "heptadecasphing-4-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75872", "l": "Conversion of malonyl-CoA and acetyl-CoA to palmitate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63591", "l": "prunetin + UDP-alpha-D-glucuronate <=> prunetin-4'-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26059", "l": "Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine = methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)", "d": [], "t": []}, {"i": "EC:2.1.1.248", "l": "\"[methylamine--corrinoid protein] Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805035", "l": "TP53 binds STK11 and NUAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34876", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) => 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17721", "l": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.8", "l": "\"long-chain-acyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251942", "l": "Hikeshi binds HSP70s:ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71182", "l": "L-histidine(out) + L-tryptophan(in) <=> L-histidine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698016", "l": "PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008520", "l": "L-ascorbate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018456", "l": "aryl-alcohol dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52681", "l": "acetyl-CoA + L-alpha-phenylglycine => CoA + H(+) + N-acetyl-L-alpha-phenylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692755", "l": "CDK1 phosphorylates MAPK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983285", "l": "RAD51B binds RAD51C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141093", "l": "5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase activity", "d": ["Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H+ + L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66098", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine => 3-phenylpyruvate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72231", "l": "chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out) = chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70006", "l": "6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68978", "l": "7-oxoglycolithocholate + H(+) + NADPH => glycoursodeoxycholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875591", "l": "DOCK7 activates RAC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.17", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858636", "l": "MITF-M-dependent PLK1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75648", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (8R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0097004", "l": "adipokinetic hormone binding", "d": ["Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30415", "l": "H(+) + 2 NADPH + O2 + octadecanal = formate + H2O + heptadecane + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32405", "l": "(1R,4R)-dihydrocarvone + H(+) + NADH => (1R,2S,4R)-neodihydrocarveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692880", "l": "HRH3 binds Hist (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64992", "l": "acetyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17927", "l": "H(+) + L-arabinono-1,4-lactone + NADH => alpha-L-arabinopyanose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36213", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63825", "l": "2 3-(4-hydroxyphenyl)pyruvate => aspulvinone E + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195275", "l": "Phosphorylation of APC component of the destruction complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18640", "l": "H2 + NADP(+) <=> H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193684", "l": "p62 recruits an atypical PKC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2168886", "l": "Hemopexin binds Hemes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78490", "l": "CMP-5'-(3-amino-3-carboxypropyl)phosphonate + H(+) <=> CMP-5'-(3-aminopropyl)phosphonate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45827", "l": "H(+) + L-serine <=> CO2 + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21945", "l": "ATP + D-cellobiose => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75273", "l": "5-methoxytryptamine + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37087", "l": "[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839358", "l": "Endocytosis of TGFBR3:ARRB complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.20", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9838289", "l": "CLPXP degrades mitochondrial matrix proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18108", "l": "ATP + Ca(2+)(in) + H2O <=> ADP + Ca(2+)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66332", "l": "L-aspartate(out) = L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018680", "l": "deethylatrazine monooxygenase activity", "d": ["Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008694", "l": "3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity", "d": ["Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24371", "l": "L-ornithine <=> L-proline + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52508", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63219", "l": "7-cyano-7-carbaguanosine(15) in tRNA + L-lysine <=> 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33448", "l": "4beta-methylzymosterol-4alpha-carboxylate + NADP(+) => 3-dehydro-4-methylzymosterol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39218", "l": "(2E)-hexacosenoyl-CoA + H(+) + NADPH <=> hexacosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24469", "l": "H(+) + N,N-dimethylaniline + NADPH + O2 => H2O + N,N-dimethylaniline N-oxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31318", "l": "(2R)-3-phosphoglycerate + GDP-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72118", "l": "glycine betaine(out) + Na(+)(out) <=> glycine betaine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39173", "l": "(3R)-hydroxyeicosanoyl-CoA + NADP(+) => 3-oxoeicosanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19130", "l": "ATP + thymidine => ADP + dTMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647746", "l": "EML4 trimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30816", "l": "beta-nicotinamide D-ribonucleotide + H2O => beta-nicotinamide D-riboside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16451", "l": "CoA + H(+) + N(6')-acetylkanamycin B => acetyl-CoA + kanamycin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687875", "l": "Defective SFTPA2 does not translocate from ER membrane to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961619", "l": "CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0008028", "l": "monocarboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679266", "l": "Beclin-1 complex translocates to the ER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34500", "l": "1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] => H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11372", "l": "ATP + L-aspartate + NH4(+) = AMP + diphosphate + H(+) + L-asparagine", "d": [], "t": []}, {"i": "EC:6.3.1.1", "l": "\"aspartate--ammonia ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66005", "l": "coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein] => Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63762", "l": "1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23622", "l": "AMP + deoxyamidinoproclavaminate + diphosphate + H(+) => ATP + N(2)-(2-carboxyethyl)-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28508", "l": "4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+) => alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630795", "l": "p16INK4A mutants do not bind CDK4,CDK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31867", "l": "(S)-2,3-epoxysqualene = baccharis oxide", "d": [], "t": []}, {"i": "EC:5.4.99.51", "l": "\"baccharis oxide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74195", "l": "aspulvinone E + O2 = (5Z)-3-(3,4-dihydroxyphenyl)-5-[(3,4-dihydroxyphenyl)methylidene]-5-oxo-2,5-dihydrofuran-3-olate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9650858", "l": "Meglitinides bind ABCC8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204779", "l": "Interaction of Tie2 with Ang1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450499", "l": "Protein Kinase B (AKT) phosphorylates KSRP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8963915", "l": "1,25(OH)2D binds VDR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54582", "l": "a 5'-end 5'-phospho-ribonucleoside-RNA + ADP + H(+) => a 5'-end dephospho-ribonucleoside-RNA + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60651", "l": "an N-(acyl)-sphingosylphosphoethanolamine <=> an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044717", "l": "8-hydroxy-dADP phosphatase activity", "d": ["Catalysis of the reaction: 8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate."], "t": []}, {"i": "REACT:R-HSA-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51569", "l": "(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11117", "l": "acetyl-CoA + an alkane-alpha,omega-diamine => an N-acetylalkane-alpha,omega-diamine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1236970", "l": "Proteasomal clevage of exogenous antigen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682544", "l": "nsp14 binds nsp10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875183", "l": "CBL monoubiquitinates activated MET (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380316", "l": "Association of NuMA with microtubules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64625", "l": "(2E)-geraniol + acetyl-CoA => (2E)-geranyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.20.98.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67392", "l": "2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018768", "l": "RHOU auto-activates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15257", "l": "D-threonine = acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60977", "l": "(E)-4-hydroxynon-2-en-1-ol + NAD(+) => (E)-4-hydroxynon-2-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462005", "l": "pro-defensin alpha 5 is secreted (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59519", "l": "acetylsalicylate + L-lysyl-[protein] <=> H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785898", "l": "IL4R binds JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27282", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)", "d": [], "t": []}, {"i": "EC:3.5.1.102", "l": "\"2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70393", "l": "CoA + H(+) + N-eicosanoyl-3-oxosphinganine => 3-oxosphinganine + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.61", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909724", "l": "Recruitment of IFNAR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75808", "l": "Na(+)(out) + propanoate(out) => Na(+)(in) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835121", "l": "Heparin binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043717", "l": "2-hydroxyglutaryl-CoA dehydratase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyglutaryl-CoA = H2O + glutaconyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163418", "l": "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42527", "l": "uridine(1911/1915/1917) in 23S rRNA <=> pseudouridine(1911/1915/1917) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701147", "l": "TRPV1 binds TRPV1 blockers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47345", "l": "7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001859", "l": "complement component C3dg receptor activity", "d": ["Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615501", "l": "MIR132 gene expression is stimulated by p-S133-CREB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51458", "l": "(9Z)-octadecenoate + L-isoleucine => H2O + N-(9Z-octadecenoyl)-L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047035", "l": "testosterone dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73945", "l": "griseofulvin + NADP(+) => dehydrogriseofulvin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77680", "l": "a globoside MSGG (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a globoside DSGG (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033529", "l": "TYSND1 cleaves ACAA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877361", "l": "Pyrin binds ASC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0005234", "l": "extracellularly glutamate-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805122", "l": "AURKB binds TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0001064", "l": "single subunit type RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-500717", "l": "Activation of GRIK3 homomer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937419", "l": "CBR3 reduces DOX to DOXOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75799", "l": "Na(+)(out) + pyruvate(out) = Na(+)(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41255", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19692", "l": "L-rhamnulose 1-phosphate <=> (S)-lactaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218812", "l": "FYN phosphorylates PAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59155", "l": "ATP + CoA + pseudomonate C <=> AMP + diphosphate + pseudomonoyl-CoA C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373741", "l": "SDK2 homophillic interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047933", "l": "glucose-1,6-bisphosphate synthase activity", "d": ["Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031732", "l": "CCR7 chemokine receptor binding", "d": ["Binding to a CCR7 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003910", "l": "DNA ligase (ATP) activity", "d": ["Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75838", "l": "(5S)-hydroperoxy-(6E,8Z)-octadecadienoate + 2 glutathione <=> (5S)-hydroxy-(6E,8Z)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10619", "l": "(2R,3S)-catechin + H2O + NADP(+) <=> (2R,3S,4S)-leucocyanidin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709454", "l": "EPOR binds EPOR agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030737", "l": "iodophenol O-methyltransferase activity", "d": ["Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507870", "l": "Aquaporins passively transport water out of cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22992", "l": "3-oxopropanoate + CoA + NAD(+) = acetyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77011", "l": "(2S)-2-amino-3-methylbutan-1-ol + H2O + NAD(+) = 1-hydroxy-3-methylbutan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21560", "l": "3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol = 1,4-dithiothreitol + 2,3-epoxyphylloquinone", "d": [], "t": []}, {"i": "EC:1.17.4.5", "l": "\"vitamin-K-epoxide reductase (warfarin-insensitive)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56383", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2 <=> (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58244", "l": "H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] = ADP-D-ribose + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34054", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H2O <=> 6'''-deamino-6'''-hydroxyneomycin C + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008692", "l": "IL37(?-218) binds SMAD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350598", "l": "Arginine<=>Agmatine+CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48447", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol <=> a fatty acid + H(+) + long chain 2-acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726621", "l": "PGR binds PGR antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52599", "l": "lithocholoyl-CoA + NAD(+) <=> 3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40582", "l": "1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62605", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388814", "l": "Grb2 binds CD28 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54107", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51707", "l": "S-adenosyl-L-methionine + xanthohumol <=> 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74688", "l": "a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + A + a macrocyclic archaeaol phospholipid + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446364", "l": "Migfilin interacts with VASP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16665", "l": "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate", "d": [], "t": []}, {"i": "EC:3.3.2.7", "l": "\"hepoxilin-epoxide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55049", "l": "(3E,5Z)-dodecadienoyl-CoA + H2O => (3E,5Z)-dodecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10591", "l": "4 (R)-methylmalonyl-CoA + 12 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 8 NADPH <=> 4 CO2 + 4 CoA + 4 H2O + 8 NADP(+) + tetramethylated-mycocerosoyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25341", "l": "H(+) + urea <=> isocyanate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201629", "l": "Caspase-mediated cleavage of Tau (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948066", "l": "K63polyUb-IRAK1 dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693575", "l": "DNA-PKcs autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52707", "l": "H2O + UMP <=> D-ribose 5-phosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30027", "l": "D-glyceraldehyde + H(+) + NADH = glycerol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39816", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate => (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21927", "l": "3-dehydro-L-gulonate + NAD(+) <=> 2,3-dioxo-L-gulonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47487", "l": "deoxycholate + NAD(+) <=> 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76608", "l": "(9Z,12Z,15Z)-octadecatrienoate + H2O => (12Z,15Z)-10-hydroxyoctadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45573", "l": "[(1->4)-beta-D-mannuronosyl](n) => [alginate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9844955", "l": "CLN3 transports GalCer to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195378", "l": "Homodimerization of VEGF proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191784", "l": "snRNA Cap hypermethylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062076", "l": "acyl-CoA delta5-desaturase activity", "d": ["Catalysis of the reaction: (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA) and add a fourth double bond (a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33841", "l": "7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate => (2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956568", "l": "RUNX1 binds the core TAL1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65964", "l": "ATP + H2O + taurocholate(out) = ADP + H(+) + phosphate + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26326", "l": "(8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine => (8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200396", "l": "Creatine transport across the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0032217", "l": "riboflavin transmembrane transporter activity", "d": ["Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019980", "l": "interleukin-5 binding", "d": ["Binding to interleukin-5."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27334", "l": "6-hydroxynicotinate + 2 H(+) + NADH + O2 => 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54674", "l": "(+)-kolavelool + diphosphate => (+)-kolavenyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839110", "l": "p-BCR-p-FGFR1 phosphorylates GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39974", "l": "1-aminocyclopropane-1-carboxylate <=> 2-aminobut-2-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113402", "l": "Formation of DSIF:NELF:early elongation complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14215", "l": "ADP + beta-D-fructose 1,6-bisphosphate + H(+) => ATP + beta-D-fructose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45190", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54174", "l": "2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33632", "l": "ATP + CoA + octanoate => AMP + diphosphate + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21098", "l": "3-dehydroshikimate + H2O => 3-dehydroquinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70728", "l": "3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O => 6-sulfo-alpha-D-quinovose + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54143", "l": "cytidine(49) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20326", "l": "N-hydroxy-4-acetylaminobiphenyl => N-acetoxy-4-aminobiphenyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169895", "l": "Crk's SH3 domain engages C3G (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876446", "l": "p-ULK1 phosphorylates DENND3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60270", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45053", "l": "(2E)-butenoyl-CoA + (R)-carnitine => CoA + O-(2E)-butenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033781", "l": "cholesterol 24-hydroxylase activity", "d": ["Catalysis of the reaction: cholesterol + H+ + NADPH + O2 = (24S)-24-hydroxycholesterol + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72308", "l": "L-glutamate(in) + taurocholate(out) => L-glutamate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25070", "l": "3-hydroxybenzoate + ATP + CoA = 3-hydroxybenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.37", "l": "\"3-hydroxybenzoate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74806", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76488", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-acyl-1-deoxysphinganine + O2 => 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-1-deoxysphing-14Z-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549304", "l": "OCT3 mediates renal clearance of organic cations (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54351", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50199", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65184", "l": "2-oxoglutarate + O2 + preaustinoid A1 = berkeleyone B + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213201", "l": "Formation of collagen fibres (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755303", "l": "26S proteasome degrades HIFalpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24243", "l": "A + AMP + 2 H(+) + sulfite <=> adenosine 5'-phosphosulfate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67226", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA => (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61297", "l": "5-deoxy-alpha-D-ribose 1-phosphate => 5-deoxy-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68230", "l": "glycine(out) + Na(+)(out) => glycine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41991", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004021", "l": "L-alanine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19089", "l": "S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-1 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10823", "l": "D-threo-isocitrate <=> D-erythro-isocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38231", "l": "(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823836", "l": "SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759129", "l": "NFE2L2 binds the PRDX1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74853", "l": "(R)-salsolinol + H2O => acetaldehyde + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39052", "l": "ATP + cholesterol(in) + H2O => ADP + cholesterol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.8", "l": "\"glycerol-3-phosphate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34021", "l": "a fatty acid + glycerol + H(+) => a 1-acylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20685", "l": "galactitol + NAD(+) = H(+) + keto-D-tagatose + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.16", "l": "\"galactitol 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35233", "l": "rifampicin(out) => rifampicin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014449", "l": "RHOG binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.7", "l": "\"3-hydroxymethylcephem carbamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49677", "l": "H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 => H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13573", "l": "[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate = [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.43", "l": "\"polygalacturonate 4-alpha-galacturonosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050239", "l": "pyrithiamine deaminase activity", "d": ["Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425861", "l": "Activation of Protein Kinase C novel isoforms (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39405", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+) => (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13274", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol => 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858559", "l": "MITF-M dimer binds the BCL2A1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44016", "l": "2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) = 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51916", "l": "(2S)-2-amino-3-butenoate + H2O = 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651792", "l": "LIG1 and POLB dissociate from repaired dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32418", "l": "(1S,2S,4R)-isodihydrocarveol + NAD(+) <=> (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9823065", "l": "GPIb:IX:V binds to VWF multimer:collagen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68958", "l": "H(+) + S-adenosyl-L-homocysteine + scoparone => S-adenosyl-L-methionine + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.134", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32656", "l": "a carboxylate + eugenol + NADP(+) => a coniferyl ester + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173636", "l": "Formation of classic pathway C5 convertase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77672", "l": "a globoside GalGb4Cer (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a globoside MSGG (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684261", "l": "MAP3K8 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66328", "l": "taurine(out) = taurine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18373", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.154", "l": "\"phosphatidylinositol-4-phosphate 3-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61196", "l": "(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74774", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine <=> 3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9761027", "l": "ZEB2 binds SP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58433", "l": "(E)-4-oxonon-2-en-1-ol + NADP(+) => (E)-4-oxonon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28948", "l": "H(+)(out) + L-arabinose(in) => H(+)(in) + L-arabinose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12835", "l": "a carboxylate + D-glutamate => an N-acyl-D-glutamate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42198", "l": "(9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19614", "l": "dimethyl sulfide + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + trimethylsulfonium", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632668", "l": "SMO translocates to the cilium (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47013", "l": "[DsrC protein]-disulfide + H(+) + hydrogen sulfide => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44110", "l": "2 H(+) + heptanoate + NADH => H2O + heptanal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672957", "l": "PP2A dephosphorylates KSR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52785", "l": "2-sulfenohercynine + AH2 + H(+) => A + ergothioneine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9660557", "l": "RAS:GTP binds RAL GDS proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102680", "l": "campest-4-en-3-one hydroxylase activity", "d": ["Catalysis of the reaction: H+ + campest-4-en-3-one + O2 + NADPH = (22S)-22-hydroxycampest-4-en-3-one + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34097", "l": "CO2 + spermidine => carboxyspermidine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189439", "l": "ALAD condenses 2 dALAs to form PBG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78537", "l": "N-acetyl-alpha-neuraminate(in) + 2 Na(+)(in) => N-acetyl-alpha-neuraminate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803871", "l": "TP53 stimulates SFN expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798748", "l": "Exocytosis of secretory granule lumen proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015517", "l": "galactose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35431", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside = cyanidin 3,7-di-O-beta-D-glucoside + vanillate", "d": [], "t": []}, {"i": "EC:2.4.1.300", "l": "\"cyanidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391936", "l": "EP1 receptor can bind PGE2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.77", "l": "\"taurine--pyruvate aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004080", "l": "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30616", "l": "15-cis-phytoene + 2 A => 2 AH2 + all-trans-zeta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61841", "l": "brassicasterol + UDP-alpha-D-glucose => brassicasterol 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203979", "l": "Coat Assembly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0003785", "l": "actin monomer binding", "d": ["Binding to monomeric actin, also known as G-actin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78242", "l": "D-allo-threonine + H2O + O2 <=> (R)-3-hydroxy-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68632", "l": "3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = 2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:7.1.1.11", "l": "\"ferredoxin--NAD(+) oxidoreductase (H(+)-transporting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36937", "l": "(9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11521", "l": "(-)-menthol + UDP-alpha-D-glucose => (-)-menthyl beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16396", "l": "H2O + juvenile hormone II <=> H(+) + juvenile hormone II carboxylate + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047335", "l": "3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity", "d": ["Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694421", "l": "PP6 dephosphorylates SEC24 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604308", "l": "NICD4 traffics to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54538", "l": "a very long-chain fatty acyl-CoA + AMP + diphosphate => a very long-chain fatty acid + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043791", "l": "dimethylamine methyltransferase activity", "d": ["Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665998", "l": "MKL1 binds SRF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60742", "l": "(S)-(-)-citronellate + 2 H(+) + NADPH => (S)-(-)-citronellal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9650473", "l": "SERPING1 is secreted (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23930", "l": "acetate + spermidine => H2O + N(8)-acetylspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018685", "l": "alkane 1-monooxygenase activity", "d": ["Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18231", "l": "glyoxylate + H(+) + NADH => glycolate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002401", "l": "Association of procollagen type XVIII (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.18", "l": "\"lycopene epsilon-cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.354970481220079", "identifiers": [{"i": "GO:0004529", "l": "DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018650", "l": "styrene monooxygenase activity", "d": ["Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53436", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674563", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70693", "l": "chloride(in) + glycine(in) + 2 Na(+)(in) => chloride(out) + glycine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68455", "l": "all-trans-10'-apo-beta-carotenal + O2 <=> 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30015", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852716", "l": "Thrombin, ELANE cleave C5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196026", "l": "Dab2 is recruited to the junctional plaques (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786421", "l": "CHIA hydrolyses chitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55174", "l": "2-hydroxyhexanoyl-CoA + CO2 + succinate => 2-oxoglutarate + hexanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61719", "l": "ATP + D-galactofuranose(out) + H2O <=> ADP + D-galactofuranose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70070", "l": "a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13899", "l": "prephenate => chorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69078", "l": "(R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+) => (R)-noradrenaline + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15009", "l": "(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.3", "l": "\"dihydrofolate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38722", "l": "(R)-carnitine(out) + ATP + H2O <=> (R)-carnitine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22073", "l": "ATP + L-ribulose => ADP + H(+) + L-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12737", "l": "5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine = [PrdC protein]-L-selenocysteine/L-cysteine + D-proline", "d": [], "t": []}, {"i": "EC:1.21.4.1", "l": "\"D-proline reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57284", "l": "a guanosine in RNA + methylglyoxal = an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21619", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33450", "l": "4beta-methylzymosterol-4alpha-carboxylate + NADP(+) <=> 3-dehydro-4-methylzymosterol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56426", "l": "(9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine => H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024723", "l": "EPO:p-EPOR:p-JAK2:LYN:IRS2 binds CRKL:RAPGEF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64097", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] => 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022399", "l": "ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18842", "l": "(R)-glycerate + NADP(+) => 2-hydroxy-3-oxopropanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871373", "l": "BMX phosphorylates RUFY1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9842671", "l": "Active LTK binds IRS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65594", "l": "4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50968", "l": "adenosine(37) in tRNA(Ala) + H(+) + H2O = inosine(37) in tRNA(Ala) + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.34", "l": "\"tRNA(Ala)(adenine(37)) deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63194", "l": "glycine betaine + 2 H(+) + phosphate => [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39308", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH => (11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41399", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine <=> 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43372", "l": "an N-acylsphing-4-enine + dTDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55032", "l": "an N-methylornithine lipid + S-adenosyl-L-methionine = an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23362", "l": "alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP => L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77101", "l": "2-deoxy-D-ribose 5-phosphate + 5-hydroxymethyluracil => 5-hydroxymethyl-dUMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53561", "l": "9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246444", "l": "SLC22A17 binds LCN2:2,5DHBA:Fe3+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684218", "l": "M protein oligomerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14162", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 => 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29891", "l": "ATP + H2O + L-histidine(out) = ADP + H(+) + L-histidine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14844", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297275", "l": "CD9:Izumo Binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36455", "l": "ATP + H2O + L-alanylglycine(out) = ADP + H(+) + L-alanylglycine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47232", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10992", "l": "glycolate + NADP(+) = glyoxylate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.79", "l": "\"glyoxylate reductase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77481", "l": "(2S)-2-hydroxy-2-methylhexanenitrile => hexan-2-one + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35024", "l": "hydroquinone O-beta-D-glucopyranoside(out) => hydroquinone O-beta-D-glucopyranoside(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0042879", "l": "aldonate transmembrane transporter activity", "d": ["Enables the transfer of aldonate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218815", "l": "p-6Y-VEGFR2 binds NCK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47562", "l": "a ganglioside GM1b (d18:1(4E)) + CMP + H(+) => a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676133", "l": "CD74 binds MIF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72467", "l": "2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA = 6 CO2 + 8 CoA + H2O + o-orsellinate depside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44552", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O = H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018558", "l": "5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity", "d": ["Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691004", "l": "XPC binds RAD23 and CETN2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37434", "l": "12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16412", "l": "1,2-dihydrovomilenine + NADP(+) <=> H(+) + NADPH + vomilenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50713", "l": "chloride + FADH2 + O2 + tetracycline => 7-chlorotetracycline + FAD + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953013", "l": "E2F7 binds E2F8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48423", "l": "a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GM1 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16352", "l": "AH2 + chlorate <=> A + chlorite + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24095", "l": "2 H(+) + O2 + 2 sulochrin <=> 2 (2S)-bisdechlorogeodin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54234", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-dioctanoyl-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14825", "l": "(1R,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.275", "l": "\"(+)-trans-carveol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.122", "l": "\"transmembrane protease serine 2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-593685", "l": "Netrin-4 binds DCC/UNC5A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944240", "l": "Association of procollagen type III (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50154", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59294", "l": "D-galactose + N-octadecanoylsphing-4-enine => beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45047", "l": "2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2 <=> 2 Fe(III)-[cytochrome c] + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48716", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19535", "l": "CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+) => 2 H(+) + 2 H2O + N(2)-succinyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72103", "l": "Na(+)(out) + O-propanoyl-(R)-carnitine(out) = Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34137", "l": "Delta(9)-tetrahydrocannabinolate + H2O2 => cannabigerolate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45476", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64422", "l": "H(+)(in) + L-alanyl-L-proline(in) => H(+)(out) + L-alanyl-L-proline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202127", "l": "eNOS synthesizes NO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008939", "l": "nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H+ + nicotinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17238", "l": "ATP + FMN + H(+) => diphosphate + FAD", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70913", "l": "(2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416562", "l": "p190RhoGAP binds Plexin-B1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21554", "l": "CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050232", "l": "putrescine oxidase activity", "d": ["Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20733", "l": "[protein]-dithiol + [thioredoxin]-disulfide => [protein]-disulfide + [thioredoxin]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26177", "l": "1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine => 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42221", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10667", "l": "NAD(+) + perillyl alcohol <=> H(+) + NADH + perillyl aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48332", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39637", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20738", "l": "(2S)-2-amino-3-oxobutanoate + CoA => acetyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654533", "l": "KRAS4B recycles to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362522", "l": "ALDHs oxidise atRAL to atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23413", "l": "H2O + N-acetylputrescine => acetate + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16342", "l": "(R)-5-phosphomevalonate + ATP => (R)-5-diphosphomevalonate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804425", "l": "TP53 binds POU4F2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30656", "l": "ATP + dUMP => ADP + dUDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570528", "l": "SUMOylation of XPC with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607733", "l": "BCL10 binds CARD9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266303", "l": "Spherical HDL binds C and E apolipoproteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55201", "l": "5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine => 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140836", "l": "RNA polymerase II CTD heptapeptide repeat S5 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 5)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47836", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + ATP = [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP", "d": [], "t": []}, {"i": "EC:2.7.4.31", "l": "\"[5-(aminomethyl)furan-3-yl]methyl phosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61504", "l": "pelargonidin + UDP-alpha-D-glucose = pelargonidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19573", "l": "[phosphate](n) + ATP = [phosphate](n+1) + ADP", "d": [], "t": []}, {"i": "EC:2.7.4.1", "l": "\"ATP-polyphosphate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62317", "l": "salicylate + UDP-alpha-D-glucose => 1-O-salicyl-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9853878", "l": "FIGNL1 binds DMC1, RAD51 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106293", "l": "NADH oxidase H202-forming activity", "d": ["Catalysis of the reaction: NADH + H+ + O2 = NAD + hydrogen peroxide (H2O2)."], "t": []}, {"i": "RHEA:11264", "l": "H(+) + NADH + O2 = H2O2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23333", "l": "(2R)-3-phosphoglycerate + GTP => (2R)-3-phospho-glyceroyl phosphate + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018756", "l": "RHOH binds GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66847", "l": "asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] <=> asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72343", "l": "3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70314", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395992", "l": "p-T,4S-IRF3 is dimerized (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858482", "l": "DVL is recruited to the receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10378", "l": "ADP + Cu(2+)(out) + H(+) + phosphate => ATP + Cu(2+)(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5444516", "l": "Formation of MSH2:MSH6 Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47182", "l": "(25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH => (25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14479", "l": "a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5615668", "l": "AKR1C3 reduces atRAL to atROL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856951", "l": "PP2A demethylation by PPME1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422454", "l": "Polysialylation of NCAM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35058", "l": "3,6-dichlorocatechol + O2 <=> (2E,4E)-2,5-dichloromuconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67550", "l": "[protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35738", "l": "a (2R)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030622", "l": "U4atac snRNA binding", "d": ["Binding to a U4atac small nuclear RNA (U4atac snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610720", "l": "PKA phosphorylates GLI3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655295", "l": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-217255", "l": "FMO1:FAD N-oxidises TAM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938121", "l": "SERPINB13 binds CTSK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444171", "l": "Receptor FFAR2 binds carboxylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60060", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26475", "l": "beta-D-galactosyl-(1->4)-L-rhamnose + phosphate => alpha-D-galactose 1-phosphate + L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42134", "l": "nocardicin C => isonocardicin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38347", "l": "(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.103", "l": "\"(S)-3,5-dihydroxyphenylglycine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67127", "l": "a hydroperoxide + L-cysteinyl-[protein] <=> an alcohol + S-hydroxy-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40135", "l": "(9Z)-tetradecenoyl-CoA + H2O = (9Z)-tetradecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3229181", "l": "CALM1:Ca2+ binds CNG channel (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008819", "l": "cobinamide kinase activity", "d": ["Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78334", "l": "UMP + UTP <=> 2 UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62494", "l": "AMP + diphosphate + L-arginyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20327", "l": "N-acetoxy-4-aminobiphenyl => N-hydroxy-4-acetylaminobiphenyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21675", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32214", "l": "(Z)-5-oxohex-2-enedioate <=> (2E,4Z)-2-hydroxyhexa-2,4-dienedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162188", "l": "COQ5 methylates MDMQ10H2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38885", "l": "a fatty acyl-CoA + AMP + diphosphate => a fatty acid + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48896", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a = 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36779", "l": "2-oxoglutarate + GDP-alpha-D-perosamine = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.102", "l": "\"GDP-perosamine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624798", "l": "LBR binds KPNB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51973", "l": "an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50740", "l": "H2O + leukotriene C4 = glycine + leukotriene F4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76914", "l": "(1S)-3-methyl-cyclohexylamine + H2O + NAD(+) <=> 3-methylcyclohexanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73139", "l": "lithocholate(out) = lithocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801666", "l": "PLK2 phosphorylates CENPJ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47707", "l": "H(+) + iso-precytochalasin + NADPH + O2 <=> cytochalasin Z16 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25920", "l": "A + H2O + quinolin-7-ol = 7-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019154", "l": "glycolate dehydrogenase activity", "d": ["Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69485", "l": "dodecan-1-ol + O2 => dodecanal + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14468", "l": "H2O + L-histidinol phosphate <=> L-histidinol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481007", "l": "Exocytosis of platelet alpha granule contents (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022368", "l": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-42) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0022885", "l": "bacteriocin transmembrane transporter activity", "d": ["Enables the transfer of a bacteriocin from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008915", "l": "lipid-A-disaccharide synthase activity", "d": ["Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004122", "l": "cystathionine beta-synthase activity", "d": ["Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222093", "l": "BRD7 binds TP53 and EP300 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53719", "l": "H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP <=> phosphate + UDP-N-acetyl-alpha-D-muramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13668", "l": "GTP <=> 3',5'-cyclic GMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45126", "l": "acarbose 7(IV)-phosphate + ADP + H(+) => acarbose + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627072", "l": "RHOQ binds GOPC:CFTR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835411", "l": "FA core complex:HSP70s binds PKR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604368", "l": "Autocatalytic activation of bound proMMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14850", "l": "H2O + N-amidino-L-aspartate => L-aspartate + urea", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46081", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADH => NAD(+) + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420365", "l": "Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49148", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.324", "l": "\"dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.30", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34854", "l": "(3S)-3-hydroxyadipyl-CoA + NAD(+) <=> 3-oxoadipyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102593", "l": "UDP-glucose: N-methylanthranilate glucosyltransferase activity", "d": ["Catalysis of the reaction: N-methylanthranilate + UDP-alpha-D-glucose = N-methylanthraniloyl-beta-D-glucopyranose + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017025", "l": "TBP-class protein binding", "d": ["Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66699", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57977", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose => (20S)-ginsenoside C-K + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977371", "l": "Factor I inactivates Factor H-boundC3b (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51846", "l": "(9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40443", "l": "6-deoxy-6-sulfo-D-fructose + ATP = 6-deoxy-6-sulfo-D-fructose 1-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.184", "l": "\"sulfofructose kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18403", "l": "(S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65161", "l": "benzoyl-CoA + hexan-2-ol => CoA + hexan-2-yl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76198", "l": "UDP-alpha-D-glucose(in) <=> UDP-alpha-D-glucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50876", "l": "a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH = a hydroxy polyunsaturated fatty acid + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.11.1.22", "l": "\"hydroperoxy fatty acid reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77991", "l": "9-hydroxy-octadecanoate + a 1,2-diacyl-sn-glycerol = 9-(acyloxy)-octadecanoate + a 1-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59604", "l": "H2O + O2 + spermidine = H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73337", "l": "AMP + beta-alanyl-tryptamine + diphosphate + H(+) => ATP + beta-alanine + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948034", "l": "FGR binds LDL:LRP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0015556", "l": "C4-dicarboxylate transmembrane transporter activity", "d": ["Enables the transfer of C4-dicarboxylate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11253", "l": "H(+) + hydroxylamine + L-asparagine => beta-L-aspartylhydroxamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30735", "l": "1D-myo-inositol 4-phosphate + H2O = myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466391", "l": "NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74073", "l": "ADP + an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174119", "l": "Free APC/C phosphorylated by Plk1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796368", "l": "RIPK1 binds STUB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001860", "l": "complement component C3d receptor activity", "d": ["Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42181", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23484", "l": "A + D-cellobiose = AH2 + D-cellobiono-1,5-lactone", "d": [], "t": []}, {"i": "EC:1.1.99.18", "l": "\"cellobiose dehydrogenase (acceptor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36893", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70871", "l": "L-glutamine(in) + L-valine(out) + Na(+)(out) = L-glutamine(out) + L-valine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12816", "l": "L-glutamate <=> D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626256", "l": "HSPA8:LAMP2a multimers depolymerizes to monomers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944266", "l": "Association of procollagen type XI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0005524", "l": "ATP binding", "d": ["Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator."], "t": []}, {"i": "REACT:R-HSA-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018586", "l": "mono-butyltin dioxygenase activity", "d": ["Catalysis of the reaction: butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017954", "l": "MECP2:SIN3A complex binds OPRM1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37770", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202127", "l": "eNOS synthesizes NO (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65511", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 <=> H2O2 + NH4(+) + pre-mycofactocin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65771", "l": "a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14054", "l": "D-arabinose 5-phosphate + H2O + phosphoenolpyruvate => 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110459", "l": "PIP3 dephosphorylated to PIP2 by DPTEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41651", "l": "aniline + ATP + L-glutamate <=> ADP + N(5)-phenyl-L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57146", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66651", "l": "(2E,6E)-farnesyl diphosphate <=> african-3-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444100", "l": "PROT mediates L-proline uptake (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070016", "l": "armadillo repeat domain binding", "d": ["Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signaling and cytoskeletal regulation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20421", "l": "alpha-maltose 6'-phosphate + H2O = D-glucose + D-glucose 6-phosphate", "d": [], "t": []}, {"i": "EC:3.2.1.122", "l": "\"maltose-6'-phosphate glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66399", "l": "ATP + cholate(in) + glutathione(in) + H2O <=> ADP + cholate(out) + glutathione(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41783", "l": "beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23696", "l": "myo-inositol + O2 = D-glucuronate + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.13.99.1", "l": "\"inositol oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13415", "l": "AMP + dTMP + H(+) => ADP + thymidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28269", "l": "(2E,6E)-farnesyl diphosphate <=> (S)-beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76061", "l": "H(+) + N-methylheliamine + S-adenosyl-L-homocysteine => heliamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44763", "l": "2-methoxy-6-all-trans-nonaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399712", "l": "Activation of Ca permeable AMPA receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61944", "l": "24-methylenecholesterol + UDP-alpha-D-glucose = 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653514", "l": "USP17L2 deubiquitinates RCE1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071857", "l": "beta-endorphin receptor binding", "d": ["Binding to a beta-endorphin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35701", "l": "(2S-3S)-versiconal hemiacetal + H(+) + NADPH => (S)-versiconol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18661", "l": "H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) = H(+) + L-ornithine + NADPH + pyruvate", "d": [], "t": []}, {"i": "EC:1.5.1.24", "l": "\"N(5)-(carboxyethyl)ornithine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959462", "l": "SAMD8 transfers phosphatidyl from PE onto C16DH CER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62572", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine = glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33651", "l": "(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10294", "l": "CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate => acetyl-CoA + D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839378", "l": "TGFBR3 binding to ARRB1/2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70312", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31660", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50428", "l": "methanethiol + S-adenosyl-L-methionine = dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.334", "l": "\"methanethiol S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944261", "l": "Association of procollagen type XIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11375", "l": "ATP + L-aspartate + NH4(+) <=> AMP + diphosphate + H(+) + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73298", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine <=> 7,8-dihydroxy-4'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67629", "l": "ATP + dGMP + L-aspartate => (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32007", "l": "9alpha-copalyl diphosphate = diphosphate + isopimara-8(14),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380620", "l": "Reuptake of serotonin from the synapse (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57896", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71259", "l": "2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71626", "l": "malonate(out) + phosphate(in) <=> malonate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868071", "l": "Clathrin recruits PIK3C2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190245", "l": "FGFR1b binds to FGF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40141", "l": "(9Z)-octadecenoate + CoA + H(+) => (9Z)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36669", "l": "CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine => (15Z)-tetracosenoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38861", "l": "bis(beta-D-gentiobiosyl) crocetin + H(+) + UDP => beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74321", "l": "O-acetyl-(R)-carnitine(out) => O-acetyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20805", "l": "2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) => H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592362", "l": "Activation of proMMP7 by MMP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990247", "l": "N6-methyladenosine-containing RNA reader activity", "d": ["A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005134", "l": "interleukin-2 receptor binding", "d": ["Binding to an interleukin-2 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9842648", "l": "Autophosphorylation of LTK dimer:ALKAL1,2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21128", "l": "S-adenosyl-L-methionine + zymosterol = fecosterol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750942", "l": "USP14 deubiquitinates NLRC5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38749", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429157", "l": "ABCC4 accumulation of dense granule contents (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68779", "l": "(2Z,6Z)-farnesyl diphosphate <=> diphosphate + germacrene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32994", "l": "2 a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167474", "l": "Abortive HIV-1 Initiation Before Second Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855195", "l": "I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50010", "l": "4-hydroxy-6-methylpretetramide + H2O + NADP(+) => 6-methylpretetramide + 2 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.1", "l": "\"atrolysin A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34219", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.85", "l": "\"2-hydroxymuconate-6-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70979", "l": "4-aminobutanoate(out) + n H(+)(in) = 4-aminobutanoate(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3159253", "l": "MMAB adenosylates cob(I)alamin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24443", "l": "ATP + H2O + phosphate(out) <=> ADP + H(+) + 2 phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12768", "l": "CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate <=> acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74715", "l": "Autophosphorylation of insulin receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696274", "l": "RND1 binds GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18065", "l": "ATP + H2O + phosphonate(out) = ADP + H(+) + phosphate + phosphonate(in)", "d": [], "t": []}, {"i": "EC:7.3.2.2", "l": "\"ABC-type phosphonate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823593", "l": "VWF variant does not bind to collagen type I  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74185", "l": "H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether => S-adenosyl-L-methionine + taxifolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77491", "l": "3,3-dimethylbutan-2-one + hydrogen cyanide = (2S)-2-hydroxy-2-methyl-3,3-dimethylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73167", "l": "CoA(out) + NAD(+)(in) = CoA(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102889", "l": "beta-elemene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = beta-elemene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68385", "l": "(2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein] => (2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77603", "l": "2 3-octadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-octadecanoyl-sn-glycero-1-phospho-(3'-octadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3204303", "l": "MRE11 binds cytosolic DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28452", "l": "N(6)-(D-psicosyl)-L-lysine(out) => N(6)-(D-psicosyl)-L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65740", "l": "2-oxoglutarate + nonyl sufate + O2 = CO2 + H(+) + nonanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453200", "l": "SYK autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004621", "l": "glycosylphosphatidylinositol phospholipase D activity", "d": ["Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16619", "l": "alpha-D-glucose 1-phosphate + D-glucose => beta-D-glucosyl-(1->3)-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14914", "l": "AMP + thymidine => adenosine + dTMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44186", "l": "2-epi-5-epi-valiolone + phosphate => D-sedoheptulose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0052885", "l": "all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity", "d": ["Catalysis of the reaction: H2O + all-trans-retinyl ester = 11-cis-retinol + fatty acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072345", "l": "NAADP-sensitive calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts."], "t": []}, {"i": "REACT:R-HSA-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433542", "l": "Phosphorylation and activation of VAV1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11932", "l": "2-hydroxy-2-methylpropanenitrile = acetone + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10802", "l": "5-phospho-alpha-D-ribose 1-diphosphate + xanthine => diphosphate + XMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18836", "l": "4-formylbenzenesulfonate + H2O + NAD(+) <=> 4-sulfobenzoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77305", "l": "5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine => N(omega),N(omega)-dimethyl-L-arginine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047353", "l": "N-methylphosphoethanolamine cytidylyltransferase activity", "d": ["Catalysis of the reaction: N-methylethanolamine phosphate + CTP = CDP-N-methylethanolamine + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.82", "l": "\"putrescine--2-oxoglutarate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73460", "l": "5 H(+) + 2 O2 + protochlorophyllide a + 4 reduced [2Fe-2S]-[ferredoxin] => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-481010", "l": "Surface deployment of platelet dense granule membrane components (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944219", "l": "Association of procollagen type XVI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35195", "l": "L-quinate(in) = L-quinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77214", "l": "3'-phosphoadenylyl sulfate + taurodeoxycholate <=> 3alpha-sulfotaurodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64421", "l": "H(+)(out) + L-alanyl-L-proline(out) => H(+)(in) + L-alanyl-L-proline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51640", "l": "(9Z,12Z)-octadecadienoate + O2 = (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102703", "l": "camphene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (-)-camphene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204861", "l": "Interaction of Tie2 and Shc1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32457", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone => (-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10234", "l": "5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate => 5,6-dihydrouridine 5'-phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63704", "l": "mycophenolate + UDP-alpha-D-glucuronate = H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802916", "l": "RAF is phosphorylated downstream of moderate kinase activity BRAF mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26269", "l": "Co-precorrin-2 + 3 H(+) = Co(2+) + precorrin-2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023846", "l": "Estrogen-responsive CTSD expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098821", "l": "BMP receptor activity", "d": ["Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088134", "l": "PLK1 phosphorylates FOXM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58889", "l": "4-aminobenzoate + AH2 + 2 O2 => 4-nitrobenzoate + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624949", "l": "Assembly of the anterograde IFT train (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42609", "l": "a plastoquinone + (n+1) H(+)(in) + NADH => a plastoquinol + n H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68444", "l": "5-cis-lycopene + O2 = (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634861", "l": "NPAS4 binds ARNT2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71030", "l": "L-glutamine(in) + L-phenylalanine(out) <=> L-glutamine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1369052", "l": "ABCAs mediate lipid influx (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59794", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate => H2O + NADP(+) + yersinopine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30842", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-talose <=> UDP-N-acetyl-beta-L-fucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018768", "l": "RHOU auto-activates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10058", "l": "(2E)-butenoyl-CoA + NH4(+) => (3S)-3-aminobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28833", "l": "D-gluconate(out) + H(+)(out) => D-gluconate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53180", "l": "D-erythrose = D-erythrulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005115", "l": "receptor tyrosine kinase-like orphan receptor binding", "d": ["Binding to a receptor tyrosine kinase-like orphan receptor (Ror)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65917", "l": "L-kynurenine + pyruvate => H2O + kynurenate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63535", "l": "angiotensin I + H2O <=> angiotensin-(1-9) + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60966", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP => (9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78569", "l": "3-oxotetracosanoyl-CoA + CoA => acetyl-CoA + docosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76416", "l": "Benzene is hydroxylated to phenol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416516", "l": "GRK2 sequesters activated Gq (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351913", "l": "Caspase-mediated cleavage of TJP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21680", "l": "(2S)-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.27", "l": "\"hydroxyphytanate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61586", "l": "5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655247", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 point and translocation mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66559", "l": "dopamine + L-glutaminyl-[protein] <=> 5-dopaminyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36143", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADPH = hexadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051744", "l": "3,8-divinyl protochlorophyllide a 8-vinyl reductase activity", "d": ["Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20558", "l": "2 H(+) + H2O + urea => CO2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981621", "l": "C3 convertases spontaneously dissociate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430158", "l": "p-SLP-76 binds VAV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218906", "l": "RIPK3 phosphorylates MLKL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004726", "l": "non-membrane spanning protein tyrosine phosphatase activity", "d": ["Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033906", "l": "hyaluronoglucuronidase activity", "d": ["Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16808", "l": "2-oxoglutarate + deacetoxycephalosporin C + O2 <=> CO2 + deacetylcephalosporin C + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102698", "l": "5-epi-aristolochene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-5-epi-aristolochene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25516", "l": "an acyl-CoA + tropine = CoA + H(+) + O-acyltropine", "d": [], "t": []}, {"i": "EC:2.3.1.185", "l": "\"tropine acyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64694", "l": "2-methylpropanal + H(+) + NADH => isobutanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69227", "l": "a (Z)-alkenyl glucosinolate + H2O <=> a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730840", "l": "Activation of RAC1 by VAV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391939", "l": "TP receptor can bind thromboxane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008661", "l": "1-deoxy-D-xylulose-5-phosphate synthase activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H+ + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47837", "l": "[5-(aminomethyl)-3-furyl]methyl phosphate + ATP => [5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9853512", "l": "DLST transfers succinyl to CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58952", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose = (20S)-ginsenoside Rh1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53556", "l": "(9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50798", "l": "prostaglandin A2-S-(R)-glutathione => glutathione + prostaglandin A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102493", "l": "wogonin 7-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: wogonin + UDP-alpha-D-glucose = wogonin 7-O-beta-D-glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21861", "l": "3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30375", "l": "(2E,6E)-farnesyl diphosphate = (+)-thujopsene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.79", "l": "\"thujopsene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19229", "l": "AMP + an aromatic aldehyde + diphosphate + NADP(+) = an aromatic carboxylate + ATP + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.30", "l": "\"carboxylate reductase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20847", "l": "ATP + hydrogencarbonate + pyruvate <=> ADP + H(+) + oxaloacetate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19496", "l": "D-cellobiose + phosphate <=> alpha-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449818", "l": "IL13 binds IL13RA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50932", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202375", "l": "Recruitment of ITK to SLP-76 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5591086", "l": "SERPINA5 binds activated protein C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199154", "l": "CD200 binds to CD200R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785898", "l": "IL4R binds JAK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36111", "l": "gibberellin A1 + S-adenosyl-L-methionine = O-methyl gibberellin A1 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52657", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) => a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072582", "l": "17-beta-hydroxysteroid dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+."], "t": []}, {"i": "RHEA:69284", "l": "a 17beta-hydroxy steroid + NADP(+) = a 17-oxo steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2520883", "l": "Phosphorylated condensin I promotes condensation of prometaphase chromosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74188", "l": "S-adenosyl-L-methionine + taxifolin => H(+) + S-adenosyl-L-homocysteine + taxifolin 3'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27907", "l": "butanoyl-CoA + NADP(+) => (2E)-butenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23714", "l": "H(+) + NADPH + pregnan-21-al => NADP(+) + pregnan-21-ol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607747", "l": "TRAF6 binds MALT1 oligomers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045174", "l": "glutathione dehydrogenase (ascorbate) activity", "d": ["Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27494", "l": "S-adenosyl-L-methionine + tricetin => 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71661", "l": "a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+) => a D-glucoside + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53537", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68381", "l": "3-hydroxypyruvate + L-asparagine => 2-oxosuccinamate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72063", "l": "glycoursodeoxycholate(out) + 2 Na(+)(out) = glycoursodeoxycholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850786", "l": "SPINK6 binds KLK12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768939", "l": "NPAS4 binds NPAS4 gene enhancer elements (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029690", "l": "Caspase-6 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66603", "l": "2 dopamine + O2 <=> 2 dopamine quinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15605", "l": "H2O + L-serine O-sulfate = H(+) + NH4(+) + pyruvate + sulfate", "d": [], "t": []}, {"i": "EC:4.3.1.10", "l": "\"serine-sulfate ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37457", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.76", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72887", "l": "O2 + polyporic acid + reduced [NADPH--hemoprotein reductase] = ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78948", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44735", "l": "2-(9Z,12Z-octadecadienoyl)-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72472", "l": "citrate(out) + D-threo-isocitrate(in) => citrate(in) + D-threo-isocitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63144", "l": "H2O + N-(15Z-tetracosenoyl)-ethanolamine = (15Z)-tetracosenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37495", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58501", "l": "glycine betaine + H(+) + NADH + O2 => glyoxylate + H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390846", "l": "D2D3,4 bind to DA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70131", "l": "3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173705", "l": "C5b binds C6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3321883", "l": "MSL acetylates histone H4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52009", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28166", "l": "5-nitroanthranilate + H(+) + H2O = 5-nitrosalicylate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.99.8", "l": "\"5-nitroanthranilic acid aminohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29934", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP <=> ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58563", "l": "15alpha-stemmadenine intermediate II + NADP(+) <=> 15alpha-stemmadenine intermediate I + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42951", "l": "cytidine(48) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825844", "l": "MITF-M dimer binds MLANA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051871", "l": "dihydrofolic acid binding", "d": ["Binding to dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14282", "l": "2 Fe(III)-[cytochrome c] + H2O + sulfite => 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696356", "l": "OSCAR binds collagen and SP-D (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013881", "l": "Cables1 links CDK2 and WEE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14322", "l": "morphine + NADP(+) => H(+) + morphinone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51206", "l": "12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH => 6-trans-leukotriene B4 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050289", "l": "spermidine dehydrogenase activity", "d": ["Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71721", "l": "H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in) => H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19137", "l": "17beta-estradiol + AH2 + O2 = 6beta-hydroxyestradiol-17beta + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.11", "l": "\"estradiol 6beta-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53901", "l": "ATP + L-threonyl-[myosin light chain] => ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49977", "l": "butanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9859148", "l": "BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14629", "l": "ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate", "d": [], "t": []}, {"i": "EC:2.7.2.8", "l": "\"acetylglutamate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2870221", "l": "E-selectin binds E-selectin ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57919", "l": "ATP + L-aspartyl-tRNA(Asn) <=> 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32256", "l": "meso-2,6-diaminoheptanedioate + NADP(+) => (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450466", "l": "AUF1:mRNA complex is destroyed (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371591", "l": "Trimerization of cytosolic HSF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39150", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211959", "l": "CYP3A43 6b-hydroxylates TEST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618479", "l": "ABCA1 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12408", "l": "L-lysine + NAD(+) = 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35626", "l": "D-glutamate + D-glutamine <=> gamma-D-glutamyl-D-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030781", "l": "6-O-methylnorlaudanosoline 5'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140681", "l": "histone H3K36me2/H3K36me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37732", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33290", "l": "A + spermidine <=> 1-pyrroline + AH2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9839363", "l": "TGFBR3 phosphorylation by TGFBR2 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030754", "l": "apigenin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052911", "l": "23S rRNA (guanine(745)-N(1))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanine(745) in 23S rRNA = N(1)-methylguanine(745) in 23S rRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19832", "l": "a primary alcohol + O2 <=> an aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21674", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine => [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015441", "l": "ABC-type beta-glucan transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9761344", "l": "USP18 binds IKBKG within IKK complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012835", "l": "GDIs block activation of RHOA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58700", "l": "FADH2-C4alpha-hydroperoxide + NADPH + rifampicin = FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55756", "l": "2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 = a 2-hydroxyornithine lipid + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.58", "l": "\"ornithine lipid ester-linked acyl 2-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798743", "l": "Exocytosis of secretory granule membrane proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193703", "l": "IKKbeta is activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58756", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57369", "l": "H2O + NADPH => (6R)-NADPHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68704", "l": "3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate) = 3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798044", "l": "BTG2 binds CCR4-NOT complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247922", "l": "GGCT transforms gGluCys to OPRO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10091", "l": "sucrose + UDP-alpha-D-galactose <=> 6(F)-alpha-D-galactosylsucrose + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9718360", "l": "GNRHR binds GNRHR peptide agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15952", "l": "(R)-2-hydroxyoctadecanoate + NAD(+) <=> 2-oxooctadecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419011", "l": "Transhomodimerization of Nectins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944225", "l": "Association of procollagen type XVII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28043", "l": "CoA + NAD(+) + pyruvate => acetyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13060", "l": "an N-acylneuraminate 9-phosphate + H2O <=> an N-acylneuraminate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211924", "l": "CYP4B1 12-hydroxylates ARA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964773", "l": "OXGR1 binds 2OG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473584", "l": "Collagen type III degradation by MMP15 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48407", "l": "apo-[aryl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64149", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GalNAc-R + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68106", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone => all-trans-zeaxanthin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688786", "l": "ATXN3 binds RAD23 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79155", "l": "(4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside(in) + ATP + H2O = (4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58927", "l": "(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol <=> (-)-maackiain + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24948", "l": "3-hydroxy-3-methylglutarate + malonyl-CoA = (3S)-hydroxy-3-methylglutaryl-CoA + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034578", "l": "limonene 8-hydratase activity", "d": ["Catalysis of the reaction: limonene + H2O = alpha-terpineol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78202", "l": "a 3beta-hydroxysteroid + a triacylglycerol <=> a 1,3-diacylglycerol + a 3beta-hydroxysteroid ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32623", "l": "L-threo-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836270", "l": "TFAP2A binds TFAP2C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047726", "l": "iron-cytochrome-c reductase activity", "d": ["Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632652", "l": "Hh-Npp binds CDON and PTCH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982778", "l": "Growth hormone binds the growth hormone receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29550", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine <=> 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59772", "l": "D-sorbitol + O2 = D-sorbopyranose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5220990", "l": "TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66417", "l": "ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O => ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30103", "l": "2,5-didehydro-D-gluconate + H(+) + NADH = 5-dehydro-D-gluconate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624272", "l": "MMPs cleave HB-EGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662608", "l": "MT2A binds cadmium (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018546", "l": "nitrobenzene nitroreductase activity", "d": ["Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390886", "l": "HRH4 binds Hist (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62854", "l": "GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29738", "l": "butane-1-sulfonate + FMNH2 + O2 <=> butanal + FMN + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14502", "l": "H2O + L-homocysteine => 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786621", "l": "TRMT10A methylates guanosine-9 in tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49330", "l": "2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71499", "l": "6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70263", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67702", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+) => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035276", "l": "ethanol binding", "d": ["Binding to ethanol, CH(3)-CH(2)-OH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31411", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987120", "l": "JAK1 binds IFNLR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878679", "l": "Expression of KLF15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0005388", "l": "P-type calcium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49808", "l": "a quinone + butan-1-ol = a quinol + butanal", "d": [], "t": []}, {"i": "EC:1.1.5.11", "l": "\"1-butanol dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58359", "l": "2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + L-arginyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047846", "l": "deoxynucleotide 3'-phosphatase activity", "d": ["Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43149", "l": "adenosine(9) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849908", "l": "SALM4 binds flotillin-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38889", "l": "hexanoate + sphinganine => H2O + N-hexanoyl-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0016894", "l": "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters."], "t": []}, {"i": "EC:3.1.31.1", "l": "\"micrococcal nuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75905", "l": "ADP + H(+) + O-(D-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein] => ADP-D-glycero-beta-D-manno-heptose + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73546", "l": "dCDP(out) + UTP(in) <=> dCDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043761", "l": "archaetidylserine synthase activity", "d": ["Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP."], "t": []}, {"i": "EC:2.7.8.38", "l": "\"archaetidylserine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016916", "l": "NOTCH3 coactivator complex binds the PTCRA gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63165", "l": "H2O + N-tricosanoyl-taurine => taurine + tricosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009072", "l": "STAT3 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30568", "l": "5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate => 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912366", "l": "MIR206 microRNA binds 3'UTR of NOTCH3 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23468", "l": "2-aminobenzenesulfonate + 2 H(+) + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)", "d": [], "t": []}, {"i": "EC:1.14.12.14", "l": "\"2-aminobenzenesulfonate 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31612", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene => H2O + rhodopin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168459", "l": "Lyn activates ERK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70424", "l": "an acyl-CoA + H2O => a carboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164513", "l": "3' PPT-primed initiation of plus-strand DNA synthesis  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756414", "l": "SNAI1 binds the CDH1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209792", "l": "N-acetylation of serotonin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64909", "l": "CTP + 2 H2O => CMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59651", "l": "D-xylotriono-1,5-lactone + H2O <=> D-xylotrionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864569", "l": "WWOX binds TFAP2C (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668605", "l": "RAC2:GTP binds NOX2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065355", "l": "Secreted ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25263", "l": "2-oxoglutarate + FADH2 => 2-hydroxyglutarate + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675198", "l": "Activated MAPKs phosphorylate BRAF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56111", "l": "genistein + O2 + reduced [NADPH--hemoprotein reductase] <=> 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0061609", "l": "fructose-1-phosphate aldolase activity", "d": ["Catalysis of the reaction: beta-D-fructose-1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77173", "l": "biotin + L-lysine => biocytin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16577", "l": "ADP + ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate", "d": [], "t": []}, {"i": "EC:2.7.7.53", "l": "\"ATP adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47357", "l": "an octanoate ester + H2O => an aliphatic alcohol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41577", "l": "dTDP-beta-L-mycarose + erythronolide B => 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20424", "l": "alpha-maltose 6'-phosphate + H2O <=> D-glucose + D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080068", "l": "5-methylthiopentyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 5-methylthiopentyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 5-methylthiopentyl-glucosinolate + adenosine 3',5'-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17383", "l": "(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201611", "l": "Caspase-mediated cleavage of Rock-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22790", "l": "(methylsulfanyl)acetate + H(+) + L-methionine => dimethylsulfonioacetate + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63985", "l": "5-hydroxyuridine + ATP => 5-hydroxyuridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31915", "l": "ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.175", "l": "\"maltokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28280", "l": "H(+) + L-alanine + sulfite => 3-sulfino-L-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416358", "l": "G alpha (q) inhibits PI3K alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110244", "l": "Excision of FapyG by OGG1 glycosylase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72177", "l": "5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out) => 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45700", "l": "glycine betaine + H(+) + NADH + O2 = formaldehyde + H2O + N,N-dimethylglycine + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.251", "l": "\"glycine betaine monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29134", "l": "menaquinol-8 + nitrate <=> H2O + menaquinone-8 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008454", "l": "alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851933", "l": "MET phosphorylates GAB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58842", "l": "(24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362437", "l": "C-terminal Hh fragments are bound by lectins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709831", "l": "HSP90 binds TBK1 and IRF3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617410", "l": "GLI3R binds the GLI2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62634", "l": "an alcohol + glutathione disulfide + H2O => a hydroperoxide + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29372", "l": "dAMP + H2O => 2'-deoxyadenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25405", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate => (R)-3-hydroxy-3-methyl-2-oxopentanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27775", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69940", "l": "6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55654", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757434", "l": "Acetylsalicylic acid dissolves (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23175", "l": "ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] <=> ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696482", "l": "CTF1 binds LIFR:JAKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59522", "l": "(2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate => ATP + butanoyl-CoA + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58251", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O <=> ADP-D-ribose + H(+) + L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202222", "l": "Phosphorylation of PKC theta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62141", "l": "dTMP + GTP => dTDP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61856", "l": "dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 = betaenone C + 3 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14561", "l": "(E,E)-piperoyl-CoA + piperidine = CoA + H(+) + piperine", "d": [], "t": []}, {"i": "EC:2.3.1.145", "l": "\"piperidine N-piperoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873919", "l": "Phosphorylation of JAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54210", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O => 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018814", "l": "RHOT1 hydrolyzes GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74522", "l": "1-(3-O-sulfo-beta-D-galactosyl)-ceramide + H2O <=> beta-D-Gal-(1<->1')-Cer + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29502", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-alpha-barbatene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12520", "l": "L-dopa = (E)-caffeate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28266", "l": "(2E,6E)-farnesyl diphosphate = (S)-beta-bisabolene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.55", "l": "\"(S)-beta-bisabolene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667914", "l": "ALK binds ligand midkine (MDK) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508292", "l": "SYK binds IL2RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051425", "l": "PTB domain binding", "d": ["Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67230", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22036", "l": "[phosphate](n) + D-glucose = [phosphate](n-1) + D-glucose 6-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.63", "l": "\"polyphosphate--glucose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9858589", "l": "DLD dimer dehydrogenates dihydrolipoyl (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48465", "l": "a ganglioside GM1b + H2O => a ganglioside GA1 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23062", "l": "a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate => a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725342", "l": "NPM1-ALK-dependent JUNB gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45712", "l": "3-dehydrocarnityl-CoA + CoA = acetyl-CoA + N,N,N-trimethylglycyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73581", "l": "(E,E)-piperoyl-CoA + AMP + H(+) => (E,E)-piperoyl-AMP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61314", "l": "germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11382", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate => 2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31346", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.-.-", "l": "\"Isomerases altering macromolecular conformation\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26160", "l": "(S)-2,3-epoxysqualene = thalianol", "d": [], "t": []}, {"i": "EC:5.4.99.31", "l": "\"thalianol synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67603", "l": "H2O + O(6)-methyl-dGTP <=> diphosphate + H(+) + O(6)-methyl-dGMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77547", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55696", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O = an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022368", "l": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-42) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855047", "l": "Hydrolysis of internal thioester in C4b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61128", "l": "O2 + quercetin + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41576", "l": "dTDP-beta-L-mycarose + erythronolide B = 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.328", "l": "\"erythronolide mycarosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47822", "l": "9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42204", "l": "corticosterone + NAD(+) = 11-dehydrocorticosterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66822", "l": "ADP + H(+) + Mn(2+)(out) + phosphate => ATP + H2O + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848596", "l": "PTK6 binds PXN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64302", "l": "3-phenylpropanal + L-alanine => 3-phenylpropylamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0003725", "l": "double-stranded RNA binding", "d": ["Binding to double-stranded RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21926", "l": "2,3-dioxo-L-gulonate + H(+) + NADH => 3-dehydro-L-gulonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15445", "l": "H(+) + H2O + O-carbamoyl-L-serine = CO2 + 2 NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:4.3.1.13", "l": "\"carbamoyl-serine ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804276", "l": "ATM phosphorylates TTC5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830270", "l": "Protein M2-1 forms tetramers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9865569", "l": "MT-CO2 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662773", "l": "ADAM17 binds Zn2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032556", "l": "pyrimidine deoxyribonucleotide binding", "d": ["Binding to a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33374", "l": "alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] <=> alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76952", "l": "H2O + N-methyl-2-methylpropanamine + NAD(+) => 2-methylpropanal + H(+) + methylamine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19260", "l": "a secondary alcohol + NADP(+) <=> a ketone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38120", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol => 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62761", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42512", "l": "5-acetamidopentanoate + H2O = 5-aminopentanoate + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23701", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O => (6R)-10-formyltetrahydrofolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38325", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + glycerol => 2 1-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14651", "l": "demethylmacrocin + dTDP + H(+) => demethyllactenocin + dTDP-beta-L-mycarose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37856", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA => 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707594", "l": "Hemes bind LY96 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31527", "l": "N(omega)-hydroxy-L-arginine = guanidine + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209187", "l": "Further phosphorylation of CI by CKIalphaepsilon (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51637", "l": "a quinone + H2O + selenite => a quinol + selenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58183", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH <=> all-trans-lycopaoctaene + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60881", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51535", "l": "H(+) + NADPH + O2 + urate <=> 5-hydroxyisourate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685318", "l": "BCDX2 complex formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50140", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (14S,15S)-epoxy-(5Z,8Z,10E,12E)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51571", "l": "(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43500", "l": "beta-D-glucuronate + NAD(+) = D-glucaro-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803425", "l": "TP53 binds ZNF385A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380294", "l": "Loss of C-Nap-1 from centrosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49997", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42999", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (R)-cembrene A + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79027", "l": "alpha-D-Man-(1->6)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70196", "l": "ATP + deamido-NAD(+) => ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166220", "l": "FA anion diffuses laterally to UCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73438", "l": "apigenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + ladanein + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17720", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP <=> 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675947", "l": "TNFSF18 binds TNFRSF18 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688797", "l": "ATXN3 family cleave Ub chains (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102647", "l": "D-ribose 5-phosphate:D-sedoheptulose 7-phosphate transaldolase activity", "d": ["Catalysis of the reaction: sedoheptulose 7-phosphate + D-ribose 5-phosphate = D-glycero-D-altro-octulose 8-phosphate + D-erythrose 4-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68986", "l": "a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102267", "l": "tRNA-dihydrouridine20b synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil20b in tRNA + NAD(P) = H+ + a uracil20b in tRNA + NAD(P)H."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69901", "l": "2 Na(+)(in) + thymidine(in) => 2 Na(+)(out) + thymidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15139", "l": "H(+) + keto-L-tagatose 6-phosphate + NADH => galactitol 1-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140983", "l": "calcium:manganese antiporter activity", "d": ["Catalysis of the reaction: Ca2+(in) + Mn2+(out) = Ca2+(out) + Mn2+(in)."], "t": []}, {"i": "RHEA:73059", "l": "Ca(2+)(in) + Mn(2+)(out) = Ca(2+)(out) + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5622134", "l": "CRABP1 binds atRA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372448", "l": "SLC25A12,13 exchange L-Glu and L-Asp (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34234", "l": "5-nitrosalicylate + O2 <=> 4-nitro-6-oxohepta-2,4-dienedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9718020", "l": "PTGFR binds PTGFR agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052807", "l": "aflatoxin reductase (coenzyme F420) activity", "d": ["Catalysis of the reaction: aflatoxin + 1,5-dihydrocoenzyme F420 = aflatoxin with reduced furanocoumarin moiety + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4837364", "l": "Secretion of SOD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004825", "l": "methionine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202713", "l": "CD84 homodimerises (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51207", "l": "6-trans-leukotriene B4 + NADP(+) <=> 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030412", "l": "formimidoyltetrahydrofolate cyclodeaminase activity", "d": ["Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H+ = 5,10-methenyltetrahydrofolate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109639", "l": "Formation of the closed pre-initiation complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.121", "l": "\"colneleate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76231", "l": "2-oxoglutarate(in) = 2-oxoglutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008312", "l": "7S RNA binding", "d": ["Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31913", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate => beta-D-fructose 1,6-bisphosphate + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39381", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+) => (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001567", "l": "cholesterol 25-hydroxylase activity", "d": ["Catalysis of the reaction: AH(2) + cholesterol + O2 = 25-hydroxycholesterol + A + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824472", "l": "TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37745", "l": "phosphate + prenyl-FMNH2 => dimethylallyl phosphate + FMNH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56360", "l": "13-deoxycarminomycin + H(+) + NADPH + O2 = 13-dihydrocarminomycin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37983", "l": "gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951499", "l": "Loading of antigenic peptides on to class I MHC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9639286", "l": "RRAGC,D exchanges GTP for GDP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693589", "l": "SARS-CoV-1 dsRNA intermediates bind DDX58 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24898", "l": "2 GTP = 3',3'-c-di-GMP + 2 diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.65", "l": "\"diguanylate cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53957", "l": "gamma-L-glutamyl-[BtrI ACP] + H(+) => 4-aminobutanoyl-[BtrI ACP] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56873", "l": "(S)-N-acetyl-1-phenylethylamine + H2O => (S)-1-phenylethylamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76245", "l": "[protein]-C-terminal glycine + N-terminal glycyl-[protein] => a glycyl-glycyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78922", "l": "a medium-chain (3S)-3-hydroxyacyl-CoA + NAD(+) <=> a medium-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264834", "l": "Endocytosis and degradation of apoA-I (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37398", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59803", "l": "decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67867", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] <=> 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38967", "l": "an N-acylsphing-4-enine(in) + ATP + H2O = ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22686", "l": "(2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O => 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197958", "l": "FPGS-2 transforms THF to THFPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-141437", "l": "Formation of the MCC complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29163", "l": "2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) = 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59167", "l": "ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] <=> AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617179", "l": "PRKACA phosphorylates TNNI3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65033", "l": "3 a quinone + protoporphyrinogen IX => 3 a quinol + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71451", "l": "bradykinin + H2O = bradykinin(1-7) + L-Phe-L-Arg", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60042", "l": "(2E)-3-methylhex-2-enoate + L-glutamine => H2O + N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809680", "l": "MTMR12 binds MTM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10255", "l": "H(+) + hydrogen sulfide + O-phospho-L-serine <=> L-cysteine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42042", "l": "a ganglioside Fuc-GM1 (d18:1(4E)) + GDP + H(+) => a ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0140807", "l": "NAD+-protein-glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-glutamyl-[protein] + NAD+ = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046932", "l": "sodium-transporting ATP synthase activity, rotational mechanism", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) => ATP + H2O + Na+(in), by a rotational mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70176", "l": "beta-D-glucosyl-(1->4)-D-galactose + phosphate => alpha-D-glucose 1-phosphate + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9718379", "l": "GNRHR binds chemical antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692315", "l": "OX40L binds OX40 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791164", "l": "Expression of SSR1 (Trap alpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36624", "l": "3-phenylpyruvate + S-adenosyl-L-methionine => (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0015146", "l": "pentose transmembrane transporter activity", "d": ["Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623341", "l": "p-S133 CREB1 dimer binds the CCND1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36216", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20464", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine <=> an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43089", "l": "5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine => 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679266", "l": "Beclin-1 complex translocates to the ER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18120", "l": "L-tyrosine + O2 <=> H2O + L-dopaquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40030", "l": "9alpha-copalyl diphosphate + H2O <=> (13S)-vitexifolin A + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48041", "l": "a globoside Gb4Cer + H2O => a globoside Gb3Cer + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796066", "l": "AcK-NFE2L2 binds the CCL2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75172", "l": "Formation of RAD50:MRE11 complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661419", "l": "ALB binds extracellular heme (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52452", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41445", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 => glycine + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51364", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.921694575487756", "identifiers": [{"i": "GO:0140657", "l": "ATP-dependent activity", "d": ["A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38569", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160931", "l": "Disassembly of tight junctions (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25440", "l": "(2E,6E)-farnesyl diphosphate = delta-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17429", "l": "NAD(+) + trans-4-hydroxycyclohexanecarboxylate = 4-oxocyclohexanecarboxylate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.226", "l": "\"trans-4-hydroxycyclohexanecarboxylate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-606287", "l": "RSF complex binds the centromere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69046", "l": "fumarate + H(+) + nitrite => 2-nitrobutanedioate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034013", "l": "aliphatic aldoxime dehydratase activity", "d": ["Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174070", "l": "Association of Cdh1 with the APC/C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26503", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose => 2 H(+) + ternatin C5 + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693609", "l": "ATM phosphorylates TP53 at S15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22323", "l": "2 alpha-D-glucose 1-phosphate + H2O <=> D-maltose + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50573", "l": "acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001858", "l": "complement component iC3b receptor activity", "d": ["Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453200", "l": "SYK autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372359", "l": "pyruvate + H+ [cytosol] => pyruvate + H+ [mitochondrial matrix] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42869", "l": "norspermine + S-adenosyl 3-(methylsulfanyl)propylamine => caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9824999", "l": "GSK3B phosphorylates p-S73 MITF-M at residue S69 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839390", "l": "TGFBR3 complex binds to TGFBR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74625", "l": "AMP(out) + UMP(in) => AMP(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696605", "l": "USP12, USP26 deubiquitinate AR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73580", "l": "(E,E)-piperoyl-AMP + CoA => (E,E)-piperoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429714", "l": "CSNK1G2 phosphorylates p-CERT1-2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36864", "l": "(9Z)-octadecenoyl-CoA + AH2 + O2 => (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31355", "l": "dimethyl sulfide + H(+) + NADH + O2 = formaldehyde + H2O + methanethiol + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.131", "l": "\"dissimilatory dimethyl-sulfide monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426160", "l": "SREBP1A,1C,2 binds the ACACA promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932037", "l": "RUNX1 and ESR1 bind the KCTD6 gene enhancer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840807", "l": "OPTN binds ATG9A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.249", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047808", "l": "D(-)-tartrate dehydratase activity", "d": ["Catalysis of the reaction: D-tartrate = H2O + oxaloacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74460", "l": "1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) => 1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13319", "l": "(R)-glycerate + CO2 => (2R,3R)-tartrate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696547", "l": "STAMBPL1 is a deubiquitinase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26388", "l": "all-trans-8'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987015", "l": "IL20 binds IL20RA:JAK1:IL20RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27951", "l": "L-phenylalanine(in) => L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64948", "l": "dCTP + H2O = dCDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60370", "l": "urate(in) => urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374662", "l": "Translocation of Ezrin to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35984", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.11", "l": "\"glutamate carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66048", "l": "2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507868", "l": "Aquaporins passively transport water into cells (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15850", "l": "2 Fe(III)-[cytochrome c] + L-ascorbate => 2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0022858", "l": "alanine transmembrane transporter activity", "d": ["Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63280", "l": "a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37565", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.3.6", "l": "\"N-acetyllactosaminide alpha-2,3-sialyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65113", "l": "2-oxoglutarate + aculene D + O2 => aculene C + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430096", "l": "GP1b-IX-V binds filamin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080072", "l": "spermidine:sinapoyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418856", "l": "Activation of Rac1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390912", "l": "HRH1 binds hist (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-139941", "l": "Binding of IP3 to IP3 receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27935", "l": "(3S)-3-hydroxy-D-aspartate => glycine + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63289", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61722", "l": "a 3-dehydro-D-guloside + H(+) + NADH => a D-guloside + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043793", "l": "beta-ribofuranosylaminobenzene 5'-phosphate synthase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190520", "l": "Association of Golgi  transport vesicles with microtubules (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901024", "l": "MAN1B1 hydrolyses 1,2-linked mannose (a branch) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34966", "l": "Na(+)(in) <=> Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449958", "l": "IL7:IL7R:JAK1 binds IL2RG:JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69944", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043399", "l": "tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity", "d": ["Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050403", "l": "trans-zeatin O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: trans-zeatin + UDP-D-glucose = O-beta-D-glucosyl-trans-zeatin + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534378", "l": "Hv1 Mediated H+ Permeability (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15354", "l": "all-trans-violaxanthin + L-ascorbate => all-trans-antheraxanthin + H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928657", "l": "MMP2,9 cleave EPHB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849882", "l": "SALMs 1-4 bind reticulon 3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169895", "l": "Crk's SH3 domain engages C3G (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56022", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26546", "l": "beta-alaninamide + H2O = beta-alanine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052755", "l": "reduced coenzyme F420:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: reduced coenzyme F420 + 2,3-dimethyl-1,4-naphthoquinone = coenzyme F420 + reduced 2,3-dimethyl-1,4-naphthoquinone. Reduced 2,3-dimethyl-1,4-naphthoquinone is also known as 2,3-dimethyl-1,4-hydronaphthoquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605797", "l": "SMPD1 hydrolyzes SPHM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451900", "l": "IL2RB binds JAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422454", "l": "Polysialylation of NCAM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27527", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-farnesol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74687", "l": "a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + A + a macrocyclic archaeaol phospholipid + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32406", "l": "(1R,2S,4R)-neodihydrocarveol + NAD(+) <=> (1R,4R)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34734", "l": "15-methylhexadecasphing-4-enine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72456", "l": "fumarate(out) + 3 H(+)(out) => fumarate(in) + 3 H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17413", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102919", "l": "5,6-dimethylbenzimidazole synthase activity", "d": ["Catalysis of the reaction: FMNH2 + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialuric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74238", "l": "H2O + L-threonyl-tRNA(Ser) <=> L-threonine + tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333678", "l": "CPNEs bind PL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429860", "l": "DCP1-DCP2 complex decaps mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351871", "l": "Caspase-mediated cleavage of Z0-2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17076", "l": "acetyl-CoA + cortisol <=> CoA + cortisol 21-acetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870466", "l": "RGGT:CHM binds RABs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44732", "l": "2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24633", "l": "2 H2O + 3 NADP(+) + NH4(+) => 5 H(+) + 3 NADPH + nitrite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78604", "l": "(3S)-hydroxyoctadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35288", "l": "ATP + chloramphenicol(in) + H2O => ADP + chloramphenicol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031405", "l": "lipoic acid binding", "d": ["Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382054", "l": "PDGF binds to extracellular matrix proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10244", "l": "4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.2", "l": "\"fumarylacetoacetase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32860", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35825", "l": "7,8-dihydromethanopterin + H(+) + NADH => 5,6,7,8-tetrahydromethanopterin + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16739", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) => H(+) + NADH + O2 + toluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54160", "l": "2-oxoglutarate + [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75124", "l": "(1R)-(1-hydroxyethyl)phosphonate + O2 => acetate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65209", "l": "(3S)-3-hydroxybutanoyl-CoA + H2O => (S)-3-hydroxybutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39740", "l": "3-hydroxydodecanoate + H(+) + NADPH + O2 => 3,12-dihydroxydodecanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689000", "l": "AADAC deacetylates PHEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59603", "l": "5-methoxytryptamine + H2O + O2 <=> 5-methoxyindoleacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16737", "l": "H(+) + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.11", "l": "\"toluene dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62352", "l": "H(+) + NADPH + notoamide E + O2 = H2O + NADP(+) + notoamide D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54061", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2Z,6E)-hedycaryol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42939", "l": "S-adenosyl-L-methionine + uridine(32) in tRNA <=> 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68218", "l": "1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748996", "l": "GST dimers cleave AZA to 6MP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35379", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72533", "l": "ADP + H(+) + methyl beta-D-galactoside(in) + phosphate => ATP + H2O + methyl beta-D-galactoside(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10401", "l": "L-glutamine + pyruvate => 2-oxoglutaramate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614461", "l": "Tetramerization of procollagen VI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033190", "l": "solanapyrone synthase activity", "d": ["Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49010", "l": "aurachin C epoxide + H2O + NADP(+) => aurachin C + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24246", "l": "H(+) + NADPH + tropinone => NADP(+) + pseudotropine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18686", "l": "H(+) + NADPH + O2 + pentachlorophenol => 2,3,5,6-tetrachloro-1,4-benzoquinone + chloride + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47233", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA => (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13568", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol <=> 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46426", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28001", "l": "H2O + thiamine diphosphate <=> H(+) + phosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15128", "l": "acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) <=> CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67873", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose => 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53828", "l": "2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 = a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48927", "l": "a ganglioside GM4 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47490", "l": "isodeoxycholate + NADP(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875817", "l": "MET phosphorylates STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15021", "l": "(E)-feruloyl-CoA + L-quinate = 4-O-feruloyl-D-quinate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.99", "l": "\"quinate O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165162", "l": "Phosphorylation of TSC2 by PKB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11462", "l": "AMP + D-glucose 6-phosphate + H(+) => ADP + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58673", "l": "D-glucuronate => aldehydo-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018796", "l": "4,5-dihydroxyphthalate decarboxylase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018568", "l": "3,4-dihydroxyphenanthrene dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46197", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1467466", "l": "ABCA4 mediates atRAL transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098618", "l": "selenomethionine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-selenomethionine + tRNA(Met) => AMP + diphosphate + selenomethionyl-tRNA(Met)."], "t": []}, {"i": "REACT:R-HSA-2408546", "l": "tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687088", "l": "PKA phosphorylates MAPKAPK5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52015", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA <=> 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69664", "l": "H2O + luteolin 7-O-beta-D-glucoside => beta-D-glucose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426032", "l": "DAG is metabolized by DAGL to 2-AG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65721", "l": "2-oxoglutarate + butyl sulfate + O2 => butanal + CO2 + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353494", "l": "Elongation by Pol kappa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210426", "l": "Glutamate synaptic vesicle docking and priming (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73317", "l": "1D-chiro-inositol(in) + 2 Na(+)(in) => 1D-chiro-inositol(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74280", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA => a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798749", "l": "Exocytosis of specific granule lumen proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047114", "l": "kynurenate-7,8-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: 7,8-dihydro-7,8-dihydroxykynurenate + NAD+ = 7,8-dihydroxykynurenate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59108", "l": "chenodeoxycholate + octyl beta-D-glucose = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73398", "l": "L-aspartate(in) + sulfate(out) <=> L-aspartate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18942", "l": "a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) => a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60862", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209098", "l": "p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15543", "l": "DIMBOA beta-D-glucoside + H(+) + UDP => DIMBOA + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39579", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA = (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74396", "l": "2 (S)-lactate(in) + prostaglandin E1(out) => 2 (S)-lactate(out) + prostaglandin E1(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858482", "l": "DVL is recruited to the receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34059", "l": "agroclavine + NADP(+) = didehydroagroclavine + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.46", "l": "\"agroclavine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0016715", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor."], "t": []}, {"i": "EC:1.14.17.-", "l": "\"With reduced ascorbate as one donor, and incorporation of one atom of oxygen\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50520", "l": "acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50904", "l": "L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373716", "l": "DCC interacting NCK-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21952", "l": "5alpha-pregnane-3,20-dione + NADP(+) = H(+) + NADPH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64606", "l": "diphosphate + uridylyl-L-seryl-[protein] => L-seryl-[protein] + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31079", "l": "3-hydroxyisovaleryl-CoA = 3-methyl-(2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30317", "l": "7-methylxanthine + formaldehyde + H2O + NAD(+) => 1,7-dimethylxanthine + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62423", "l": "a (R)-2-hydroxy fatty acid + O2 <=> a fatty acid + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140834", "l": "RNA polymerase II CTD heptapeptide repeat S2 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphoserine (position 2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5228992", "l": "ROCK1,ROCK2 are activated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77999", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol = a 1-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12332", "l": "ATP + Fe(3+)(out) + H2O = ADP + Fe(3+)(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.7", "l": "\"ABC-type Fe(3+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836404", "l": "p-PKR dimer phosphorylates MAPT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0004725", "l": "protein tyrosine phosphatase activity", "d": ["Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59983", "l": "8-oxo-dGTP + H2O <=> 8-oxo-dGDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629679", "l": "PDE3A inhibitors bind PDE3A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12758", "l": "dihydrozeatin + NADP(+) => H(+) + NADPH + zeatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20551", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + tetrathionate => 2 Fe(III)-[cytochrome c] + 2 thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59886", "l": "4-chloro-L-lysine + CO2 + H2O + succinate => 2-oxoglutarate + chloride + H(+) + L-lysine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248694", "l": "Trans-autophosphorylation of ERBB2 homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52375", "l": "17beta-estradiol + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49565", "l": "D-sedoheptulose 7-phosphate => 2-epi-valiolone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16553", "l": "aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] = H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112385", "l": "Addition of nucleotides leads to transcript elongation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050623", "l": "berberine reductase activity", "d": ["Catalysis of the reaction: (R)-canadine + 2 NADP+ = berberine + H+ + 2 NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102862", "l": "1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity (SN2-18:3 forming)", "d": ["Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:2-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618331", "l": "HDAC6 deacetylates microtubules (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65501", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50562", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40658", "l": "(R)-malate + succinyl-CoA <=> (R)-malyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5671772", "l": "p-T38-PPP1R14A binds MLCP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877158", "l": "P2X7 forms oligomeric non-selective cation channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67316", "l": "(2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine = (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77420", "l": "(E)-hex-2-enal + hydrogen cyanide => (2S,3E)-2-hydroxyhept-3-enenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6790038", "l": "Expression of HSP90B1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657836", "l": "NR1H2,3 binds the ANGPTL3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856951", "l": "PP2A demethylation by PPME1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29520", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055053", "l": "mannose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: mannose + H+ = mannose + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222712", "l": "Nitrosoglutathione gets cleaved to Cys(NO)-Gly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41718", "l": "a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine => a 2-acyl-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061657", "l": "UFM1 conjugating enzyme activity", "d": ["Isoenergetic transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y = Y-UFM1 + X, where both the X-UFM1 and Y-UFM1 linkages are thioester bonds between the C-terminal amino acid of UFM1 and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448958", "l": "Nuclear translocation of p38 MAPK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173542", "l": "SMURF2 ubiquitinates SMAD2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58846", "l": "(6E)-8-oxogeranial + H(+) + NADH => (6E)-8-hydroxygeranial + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474210", "l": "Collagen type III degradation by MMP14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35795", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine = H(+) + kanamycin A + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009452", "l": "SMURF1 gene expression is stimulated by RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814088", "l": "SYS1 binds AcM-ARFRP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865276", "l": "PDGF-AB clevage by Furin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19520", "l": "H2O + N,N-dimethylformamide <=> dimethylamine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250220", "l": "Homodimerization of ERBB4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65249", "l": "AH2 + 5 H(+) + 5 malonyl-CoA => 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001566", "l": "non-kinase phorbol ester receptor activity", "d": ["Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938853", "l": "CDK6 binds RUNX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195251", "l": "Assembly of the destruction complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47552", "l": "glycodeoxycholate + H2O = deoxycholate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804879", "l": "MDM2 ubiquitinates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202137", "l": "AKT1 binds eNOS complex via HSP90 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102569", "l": "FR-33289 synthase activity", "d": ["Catalysis of the reaction: FR-900098 + 2-oxoglutarate(2-) + O2 = FR-33289 + succinate(2-) + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68794", "l": "ADP-D-ribose + H(+) + nicotinamide => alpha-NAD(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55928", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158860", "l": "SULT1A1 dimer sulfonates NHABP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67858", "l": "3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120509", "l": "hydroxypyruvate reductase (NADPH) activity", "d": ["Catalysis of the reaction: (R)-glycerate + NADP+ = 3-hydroxypyruvate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51112", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72341", "l": "catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52923", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944263", "l": "Association of procollagen type II (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080073", "l": "spermidine:coumaroyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a coumaroyl group to a nitrogen atom on the spermidine molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30070", "l": "betaine aldehyde + H2O + NADP(+) <=> glycine betaine + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12556", "l": "6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.31", "l": "\"6-phosphogluconolactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684261", "l": "nsp4 is glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57945", "l": "H(+) + H2O2 + harderoheme III => CO2 + 2 H2O + heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3076881", "l": "BCTN translocates to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34961", "l": "(R)-carnitine(out) => (R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0005343", "l": "organic acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)."], "t": []}, {"i": "REACT:R-HSA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418858", "l": "RhoGTPase GEF's recruited to DCC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74005", "l": "AH2 + yaequinolone E => A + peniprequinolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322429", "l": "XIAP monoubiquinates TLE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928617", "l": "EPHB2 binds KALRN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16841", "l": "precorrin-2 + S-adenosyl-L-methionine = H(+) + precorrin-3A + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.130", "l": "\"precorrin-2 C(20)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67938", "l": "a 2-oxocarboxylate + H2O2 => a 2-hydroxy carboxylate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72809", "l": "L-histidine(in) => L-histidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33964", "l": "ATP + isopentenyl phosphate => ADP + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.2.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42083", "l": "all-trans-retinal + H2O + NAD(+) <=> all-trans-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1445144", "l": "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12698", "l": "ATP + dGMP => ADP + dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15059", "l": "(9Z)-octadecenoate + H(+) + holo-[ACP] => (9Z)-octadecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244503", "l": "botE HC:LC binds SV2A or B and GT1b on the target cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17899", "l": "(S)-1-phenylethanol + AH2 => A + ethylbenzene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52528", "l": "2-oxoglutarate + L-asparagine = 2-oxosuccinamate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25971", "l": "(S)-benzoin + NADP(+) <=> benzil + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805103", "l": "AURKA phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59273", "l": "L-cysteine => D-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77649", "l": "[4-(deca-1,8-diyl)-2,5-dioxo-2,5-dihydro-3-furanyl]acetate + CoA + H2O => (2E,10E)-dode-2,10-dicenoyl-CoA + H(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48073", "l": "a ganglioside GM1 (d18:1(4E)) + H2O => a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19810", "l": "(S)-ureidoglycolate + 2 H(+) + H2O => CO2 + glyoxylate + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9861734", "l": "PDH E1 decarboxylates PYR, transferring acetyl to DLAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114671", "l": "vWF binds to collagen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14430", "l": "a [oligopeptide](in) + ATP + H2O => a [oligopeptide](out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58373", "l": "(E)-oct-2-en-1-ol + NADP(+) => (2E)-octenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047121", "l": "isoquinoline 1-oxidoreductase activity", "d": ["Catalysis of the reaction: A + H2O + isoquinoline = AH(2) + isoquinolin-1(2H)-one."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44813", "l": "1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-11 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55043", "l": "(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64367", "l": "prostaglandin G2 <=> (15S)-15-hydroperoxy-prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73561", "l": "dGTP(in) + UTP(out) => dGTP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.13", "l": "\"D-alanine--poly(phosphoribitol) ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19770", "l": "phaseollidin hydrate => H2O + phaseollidin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034737", "l": "ergosterol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23475", "l": "2 alpha,alpha'-trehalose 6-mycolate <=> alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549129", "l": "OCT1 transports organic cations into hepatic cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022399", "l": "ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16005", "l": "galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.42", "l": "\"galactarate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75360", "l": "L-mimosine => 2-aminoprop-2-enoate + 3-hydroxy-4H-pyrid-4-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31297", "l": "2-oxopent-4-enoate => (2E)-2-hydroxypenta-2,4-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53558", "l": "18-hydroxy-(9R,10S)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9R,10S)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374677", "l": "L1 binds ERM family members (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55093", "l": "D-fructose + UDP-alpha-D-glucose => H(+) + sucrose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67107", "l": "2-oxoglutarate + fumigatonoid C + O2 <=> CO2 + H2O + novofumigatonin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54486", "l": "1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036356", "l": "cyclic 2,3-diphosphoglycerate synthetase activity", "d": ["Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43771", "l": "an alkylamine + L-glutaminyl-[protein] <=> N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592278", "l": "Autocatalytic activation of proMMP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77077", "l": "2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane carbocation + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (1R,4R,5S)-acoradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62859", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41618", "l": "D-ribose 5-phosphate + phosphate => D-ribose 2,5-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807872", "l": "Active ARF recruits coatomer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14122", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807872", "l": "Active ARF recruits coatomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66285", "l": "tomatidine + UDP-alpha-D-glucose => H(+) + tomatidine 3-O-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607058", "l": "Activated protein C:PROCR binds F2R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140260", "l": "mitochondrial proton-transporting ATP synthase complex binding", "d": ["Binding to a mitochondrial proton-transporting ATP synthase complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26175", "l": "1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA <=> CoA + H(+) + mycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814096", "l": "ARL1:GTP binds SCOC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44486", "l": "3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56495", "l": "hederagenin + O2 + reduced [NADPH--hemoprotein reductase] <=> gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65112", "l": "2-oxoglutarate + aculene D + O2 = aculene C + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39788", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49249", "l": "galactitol(out) + N(pros)-phospho-L-histidyl-[protein] => galactitol 1-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60175", "l": "5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate <=> (2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683792", "l": "p-T68-CHEK2 autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48784", "l": "D-erythrulose 4-phosphate = D-erythrose 4-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.34", "l": "\"D-erythrulose 4-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74439", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48062", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55655", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74027", "l": "L-alanine(in) + L-threonine(out) = L-alanine(out) + L-threonine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49794", "l": "CoA + H(+) + N-eicosanoylglycinate => eicosanoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72422", "l": "(E)-4-coumarate + ATP + H(+) <=> (E)-4-coumaroyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015247", "l": "aminophospholipid flippase activity", "d": ["Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63753", "l": "kermesate + UDP-alpha-D-glucose => carminate + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13681", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.37", "l": "\"DNA (cytosine-5-)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654167", "l": "Activated FGFR1 binds PLCG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49575", "l": "Fe-coproporphyrin III + 2 H(+) <=> coproporphyrin III + Fe(2+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14922", "l": "(indol-3-yl)acetate + UDP-alpha-D-glucose => 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74245", "l": "H(+) + L-alanine + tRNA(Pro) => H2O + L-alanyl-tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49764", "l": "ethylenediaminetriacetate + FMNH2 + O2 = ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52921", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183032", "l": "Expression of GLUT4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10137", "l": "2 glyoxylate + H(+) => 2-hydroxy-3-oxopropanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62088", "l": "D-glucosamine 6-phosphate + NADP(+) = 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22750", "l": "2 pyruvate => 4-hydroxy-4-methyl-2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71530", "l": "thymine(out) <=> thymine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19796", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine <=> (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72463", "l": "L-threonyl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10165", "l": "(2R)-2-phosphoglycerate => H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.142", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9725206", "l": "IgE binds FCERI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68124", "l": "a 1,2-diacylglycerol + a fatty acyl-[ACP] = a triacylglycerol + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209381", "l": "AP-1 transcription factor, JRA:KAY, is phosphorylated by phosphorylated BSK kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002046", "l": "opsin binding", "d": ["Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50553", "l": "prostaglandin C1 => prostaglandin B1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13826", "l": "GDP-alpha-D-rhamnose + NAD(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9861595", "l": "Cytosolic H2O2 decarboxylates PYR to acetate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69152", "l": "Removal of remaining Flap (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47649", "l": "D-ribitol 5-phosphate + H2O => phosphate + ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112392", "l": "Resumption of elongation after recovery from pausing (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21700", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.77", "l": "\"acireductone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "45.489739324103454", "identifiers": [{"i": "GO:0015075", "l": "monoatomic ion transmembrane transporter activity", "d": ["Enables the transfer of an ion from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378956", "l": "Luteinizing hormone is a heterodimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65419", "l": "dGMP(in) + NAD(+)(out) <=> dGMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948066", "l": "K63polyUb-IRAK1 dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57453", "l": "L-glutaminyl-[protein] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102856", "l": "1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66249", "l": "CoA + IC-asc-C9-AMP => AMP + H(+) + IC-asc-C9-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12277", "l": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25190", "l": "chloroacetate + H2O => chloride + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78755", "l": "alpha-L-rhamnosyl-(1->4)-D-glucuronate = 4-deoxy-L-threo-hex-4-enopyranuronate + L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012835", "l": "GDIs block activation of RHOA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334099", "l": "UHRF1 binds chromatin with hemimethylated cytosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23619", "l": "1,2-dihydro-alpha-santonin + NADP(+) <=> alpha-santonin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19396", "l": "L-lysine + pyruvate <=> (S)-2-amino-6-oxohexanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75096", "l": "2 chloride(in) + oxalate(out) => 2 chloride(out) + oxalate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11338", "l": "deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54838", "l": "H2O + NADP(+) + pentyl acetate => H(+) + heptan-2-one + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23004", "l": "a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050113", "l": "inositol oxygenase activity", "d": ["Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748991", "l": "XDH oxidises 6MP to 6TU (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33603", "l": "H(+) + N-hexacosanoylsphinganine + NADPH + O2 = H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15138", "l": "galactitol 1-phosphate + NAD(+) => H(+) + keto-L-tagatose 6-phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75125", "l": "acetate + 2 H(+) + phosphate => (1R)-(1-hydroxyethyl)phosphonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29263", "l": "L-leucine(in) + Na(+)(in) = L-leucine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43620", "l": "L-serine + NADP(+) = aminoacetaldehyde + CO2 + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.276", "l": "\"serine 3-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828722", "l": "SH mRNA is translated into protein SH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58908", "l": "7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH = C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47763", "l": "a uridine in 21S rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75377", "l": "inosine(out) => inosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16004", "l": "H(+) + H2O + N(6)-methyl-AMP <=> IMP + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1484099", "l": "MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76289", "l": "Na(+)(in) + thymine(in) => Na(+)(out) + thymine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45936", "l": "3-methylundecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(4-methyl-2-oxododecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034579", "l": "(1-methylpentyl)succinate synthase activity", "d": ["Catalysis of the reaction: fumarate + n-hexane = (1-methylpentyl)succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032054", "l": "LXA4/B4 translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65554", "l": "an N-acyl-sphingoid base + lactose => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77682", "l": "a globoside MSGG (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a globoside DSGG (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0097509", "l": "oxanine DNA N-glycosylase activity", "d": ["DNA N-glycosylase activity acting on deaminated guanine where the resulting base (oxanine) is generated by NO- or HNO2-induced nitrosative deamination."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15645", "l": "16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] = 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate", "d": [], "t": []}, {"i": "EC:1.19.6.1", "l": "\"nitrogenase (flavodoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29008", "l": "H(+)(in) + Mn(2+)(in) => H(+)(out) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951695", "l": "TEADs:YAP1 binds CTGF gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2314678", "l": "ASA- acetylates PTGS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71680", "l": "H(+)(out) + L-lysyl-glycine(out) => H(+)(in) + L-lysyl-glycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004069", "l": "L-aspartate:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3790130", "l": "Regulation of IL6 transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51161", "l": "cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65217", "l": "3-oxododecanoyl-CoA + H2O => 3-oxododecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31686", "l": "prosolanapyrone III <=> (-)-solanapyrone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70008", "l": "anthranilate + ATP + H(+) => 2-aminobenzoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162193", "l": "COQ3 methylates DHDB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34686", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O <=> alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033823", "l": "procollagen glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64528", "l": "AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine = 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53489", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH => 11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688456", "l": "MLKL binds FLOT1, FLOT2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24885", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) <=> H(+) + L-glutamate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140949", "l": "histone H3K9 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl9-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29828", "l": "Mg(2+)(in) => Mg(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35781", "l": "mutildienyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36901", "l": "H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine => guanosine(37) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008695", "l": "3-phenylpropionate dioxygenase activity", "d": ["Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392064", "l": "G alpha (z) inhibits adenylate cyclase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9851972", "l": "PLK1 phosphorylates FIRRM at S43 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21212", "l": "H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] = 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17461", "l": "D-sedoheptulose 1,7-bisphosphate + H2O = D-sedoheptulose 7-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.37", "l": "\"sedoheptulose-bisphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641111", "l": "Parkin transfers Ub to misfolded proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0004351", "l": "glutamate decarboxylase activity", "d": ["Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53888", "l": "D-glucose 6-phosphate + TDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + TDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612445", "l": "STMN1 gene expression is stimulated by ERBB4s80 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73172", "l": "adenosine 3',5'-bisphosphate(out) + NAD(+)(in) => adenosine 3',5'-bisphosphate(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59978", "l": "CO2 + toluene => 2-phenylacetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31851", "l": "(S)-2,3-epoxysqualene = parkeol", "d": [], "t": []}, {"i": "EC:5.4.99.47", "l": "\"parkeol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944216", "l": "Association of procollagen type XV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011595", "l": "GSTZ1 dimer dehalogenates DCA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75217", "l": "H(+) + L-fucono-1,5-lactone + NADPH => beta-L-fucose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14563", "l": "CoA + H(+) + piperine => (E,E)-piperoyl-CoA + piperidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37698", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA <=> 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43756", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]", "d": [], "t": []}, {"i": "EC:2.3.1.266", "l": "\"[ribosomal protein bS18]-alanine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46196", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58668", "l": "3-deoxyfructose + NADP(+) = 3-deoxyglucosone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.128", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62388", "l": "[(1->2)-beta-D-glucosyl](n) + H2O = [(1->2)-beta-D-glucosyl](n-2) + sophorose", "d": [], "t": []}, {"i": "EC:3.2.1.214", "l": "\"exo beta-1,2-glucooligosaccharide sophorohydrolase (non-reducing end)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62256", "l": "Cd(2+)(out) + 2 hydrogencarbonate(out) = Cd(2+)(in) + 2 hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54093", "l": "3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 => 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62897", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-D-GlcNAc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15356", "l": "all-trans-violaxanthin + L-ascorbate <=> all-trans-antheraxanthin + H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78262", "l": "D-proline + O2 <=> 1-pyrroline-2-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68701", "l": "16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23196", "l": "3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine = 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine", "d": [], "t": []}, {"i": "EC:6.3.2.26", "l": "\"N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193656", "l": "p75NTR interacts with RIP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71979", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + fusoxypene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31316", "l": "(2R)-3-phosphoglycerate + GDP-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14002", "l": "choloyl-CoA + glycine => CoA + glycocholate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9724745", "l": "PLG(20-810) binds aprotinin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30248", "l": "2 H2O + 4 hnu + 2 plastoquinone-9 => O2 + 2 plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12054", "l": "diphosphate + trichodiene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070699", "l": "type II activin receptor binding", "d": ["Binding to a type II activin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27529", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-farnesol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30359", "l": "chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 = chlorophyllide b + 3 H2O + 2 NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.122", "l": "\"chlorophyllide a oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010856", "l": "adenylate cyclase activator activity", "d": ["Binds to and increases the activity of adenylate cyclase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0031795", "l": "G protein-coupled GABA receptor binding", "d": ["Binding to a G protein-coupled (metabotropic) GABA receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140631", "l": "aldehyde dehydrogenase (NAD+) inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of aldehyde dehydrogenase (NAD+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8980691", "l": "RHOA GEFs activate RHOA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51402", "l": "CoA + H(+) + N-octadecanoyl-serotonin => octadecanoyl-CoA + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39742", "l": "3-hydroxydodecanoate + H(+) + NADPH + O2 <=> 3,12-dihydroxydodecanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374298", "l": "Opioid receptors bind opioid peptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70570", "l": "H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696271", "l": "RND1 binds effectors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74013", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+) => [(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46901", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) => a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012268", "l": "ME2 tetramer decarboxylates MAL to PYR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56017", "l": "H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23563", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate <=> adenosylcob(III)alamin 5'-phosphate + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30995", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799462", "l": "TP53 family members bind the TP53I3 (PIG3) gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428752", "l": "Dissociation of the TP:Gq complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59164", "l": "ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12992", "l": "a dolichyl beta-D-mannosyl phosphate + H2O <=> a dolichyl phosphate + D-mannose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0005471", "l": "ATP:ADP antiporter activity", "d": ["Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)."], "t": []}, {"i": "RHEA:34999", "l": "ADP(in) + ATP(out) = ADP(out) + ATP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419426", "l": "Cannabinoid receptors can bind cannabinoids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41262", "l": "L-tryptophan <=> (E)-3-(indol-3-yl)acrylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45998", "l": "a 2-oxocarboxylate + a quinol + NH4(+) => a D-alpha-amino acid + a quinone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9645598", "l": "RRAGC,D hydrolyzes GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177922", "l": "EGFR dimerization (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180004", "l": "RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-tyrosine (consensus YSPTSPS)(position 1) + H2O = RNA polymerase II large subunit + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75611", "l": "H2O + plasmodiophorol A = plasmodiophorol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63752", "l": "kermesate + UDP-alpha-D-glucose = carminate + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25604", "l": "4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O <=> 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047482", "l": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity", "d": ["Catalysis of the reaction: L-lysine + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944257", "l": "Association of procollagen type XXIV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29493", "l": "cis-muurola-4(14),5-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48434", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] => ATP + N(6)-D-ribulosyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0052636", "l": "arabinosyltransferase activity", "d": ["Catalysis of the transfer of an arabinosyl group from one compound (donor) to another (acceptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604360", "l": "Initial activation of proMMP2 by MMP14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77872", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-leucine + O2 => (2S)-4-methyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]pentanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74249", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852010", "l": "BTNL2 binds activated T cells surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15330", "l": "(S)-ureidoglycolate + NAD(+) => H(+) + N-carbamoyl-2-oxoglycine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70573", "l": "argininosuccinate <=> fumarate + arginine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875523", "l": "MET binds TNS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433506", "l": "Phosphorylation of APS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78436", "l": "1-O-alkyl-2-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60267", "l": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052899", "l": "N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity", "d": ["Catalysis of the reaction: H2O + N(1),N(12)-diacetylspermine + O2 = 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0050998", "l": "nitric-oxide synthase binding", "d": ["Binding to nitric-oxide synthase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61219", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749253", "l": "Formation of MCM2-7 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56274", "l": "4 Fe(II)-[cytochrome cL] + formate + 5 H(+) => 4 Fe(III)-[cytochrome cL] + H2O + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693243", "l": "RHOD translocates to the Golgi membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862184", "l": "USP48 cleaves polyubiquitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56292", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.75", "l": "\"fenbendazole monooxygenase (4'-hydroxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420980", "l": "Activation of Ca permeable AMPA receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60219", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901242", "l": "ABC-type doxorubicin transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + doxorubicin(in) = ADP + phosphate + doxorubicin(out)."], "t": []}, {"i": "TCDB:3.A.1.105.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29117", "l": "menaquinol-8 + NADP(+) => H(+) + menaquinone-8 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31967", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.112", "l": "\"ent-cassa-12,15-diene 11-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60713", "l": "(+)-artemisinic alcohol + NAD(+) => (+)-artemisinic aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78940", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388828", "l": "PD-1 binds B7DC and B7H1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29636", "l": "D-maltopentaose + H2O => alpha-D-glucose + D-maltotetraose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41074", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.76", "l": "\"L-iduronidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186765", "l": "PLC-gamma binds to the active receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38891", "l": "H2O + N-hexadecanoylsphing-4-enine = hexadecanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29682", "l": "formate(in) <=> formate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69101", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982645", "l": "GRKs bind ADRB2:Catecholamine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61927", "l": "(2S,4R)-ketoconazole(in) + ATP + H2O <=> (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69467", "l": "2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S-adenosyl-L-methionine <=> 2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022911", "l": "CSPG is secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990174", "l": "phosphodiesterase decapping endonuclease activity", "d": ["Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592398", "l": "Activation of proMMP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35298", "l": "adenylyl-molybdopterin + H(+) + tungstate <=> AMP + H2O + W-molybdopterin cofactor", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47381", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609921", "l": "SGTA binds Tail-anchored protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11653", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77153", "l": "1D-myo-inositol 4,5-bisphosphate + phosphate => 1D-myo-inositol 1,4,5-trisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102885", "l": "alpha-cuprenene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-alpha-cuprenene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19276", "l": "H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate <=> N-acetylneuraminate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65847", "l": "ADP(out) + H(+)(out) + phosphate(in) <=> ADP(in) + H(+)(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18569", "l": "an aromatic aldehyde + H2O + O2 = an aromatic carboxylate + H(+) + H2O2", "d": [], "t": []}, {"i": "EC:1.2.3.9", "l": "\"aryl-aldehyde oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36564", "l": "GDP-beta-L-colitose + NADP(+) => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55293", "l": "pseudouridine(54) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10016", "l": "H2O + O-sinapoylcholine = (E)-sinapate + choline + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.49", "l": "\"sinapine esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036105", "l": "peroxisome membrane class-1 targeting sequence binding", "d": ["Binding to a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9680443", "l": "ROCK1,2 bind ROCKi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937369", "l": "ATAD2 binds ESR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37854", "l": "13-deoxydaunorubicin + H(+) + NADPH + O2 <=> 13-dihydrodaunorubicin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638845", "l": "CERK phosphorylates CERA to form C1P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10928", "l": "ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77226", "l": "gentamicin X2 + methylcob(III)alamin + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + cob(III)alamin + geneticin + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9612501", "l": "SGK phosphorylates CREB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9824732", "l": "G or G analog binds C-ter TLR7 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879594", "l": "SLCO4C1 mediates the transport of digoxin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55949", "l": "A + D-alanine + H2O => AH2 + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676595", "l": "TRAFs bind RANK:RANKL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212642", "l": "L-Glutamine transport into neurons (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39307", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH = (11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13691", "l": "glycerol 1-phosphate + H(+) + phosphate => diphosphate + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022378", "l": "ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17702", "l": "ATP + geranoyl-CoA + hydrogencarbonate => 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000247", "l": "C-8 sterol isomerase activity", "d": ["Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20409", "l": "alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN", "d": [], "t": []}, {"i": "EC:2.7.1.42", "l": "\"riboflavin phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805470", "l": "AMPK phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52690", "l": "3-phenylpyruvate + H(+) + NADH => 3-phenyllactate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17640", "l": "squalene <=> hop-22(29)-ene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736953", "l": "FURIN translocates to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16322", "l": "(S)-indan-1-ol + NADP(+) => H(+) + indan-1-one + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29178", "l": "2 O2 + ubiquinol-8 <=> 2 H(+) + 2 superoxide + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41426", "l": "formate + grixazone A + H(+) + 3 H2O => 2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004989", "l": "octopamine receptor activity", "d": ["Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9844955", "l": "CLN3 transports GalCer to plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727349", "l": "XDH dehydrogenates xanthine to form urate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114352", "l": "Sequestration of tBID by BCL-2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047576", "l": "4-chlorobenzoate dehalogenase activity", "d": ["Catalysis of the reaction: 4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36284", "l": "1,7-dimethylxanthine + H(+) + NADPH + O2 => 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60680", "l": "(+)-artemisinic aldehyde + H2O + NADP(+) = (+)-artemisinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627775", "l": "Autophosphorylation of PAK1,2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53722", "l": "ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate => ATP + N-acetyl-D-muramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45874", "l": "4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA => 15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56731", "l": "4-hydroxy-all-trans-beta-carotene + AH2 + O2 <=> 4,4-dihydroxy-all-trans-beta-carotene + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58981", "l": "citral + H2O + O2 => 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14491", "l": "a nucleoside 2'-phosphate + H(+) => a nucleoside 2',3'-cyclic phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9660557", "l": "RAS:GTP binds RAL GDS proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.33", "l": "\"RCR-type E3 ubiquitin transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23666", "l": "a 2-oxocarboxylate + AH2 => A + a (2R)-2-hydroxycarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49721", "l": "2 H(+) + NADH + 2 O2 + protoviolaceinate => CO2 + 2 H2O + NAD(+) + violacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008715", "l": "CDP-diacylglycerol diphosphatase activity", "d": ["Catalysis of the reaction: CDP-diacylglycerol + H2O = a phosphatidate + CMP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70171", "l": "H(+)(in) + pemetrexed(in) = H(+)(out) + pemetrexed(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76960", "l": "2-methylbutanamine + H2O + NADP(+) => 2-methylbutanal + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36982", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75549", "l": "(2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + AMP + diphosphate + 2 holo-[ACP] + 2 NADP(+) => 2 (3R)-3-isocyanylbutanoyl-[ACP] + ATP + L-lysine + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814153", "l": "ADO oxidises 2AET to HTAU (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983426", "l": "Capturing cargo and formation of prebudding complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857308", "l": "Activated CEBPB and NFKB complex bind IL8 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012016", "l": "FAHD1 dimer hydrolyses OA to PYR (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67844", "l": "a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47779", "l": "guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23034", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate => 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.26", "l": "\"pseudolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0070063", "l": "RNA polymerase binding", "d": ["Binding to an RNA polymerase molecule or complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211219", "l": "Translocation of caspase-3 to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20914", "l": "diphosphate + taxa-4,11-diene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163798", "l": "Furin cleaves pro-protein Z to protein Z (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16890", "l": "2-oxoglutarate + 6-acetamido-3-aminohexanoate => 6-acetamido-3-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37585", "l": "6-amino-2-oxohexanoate + H2O2 + NH4(+) => D-lysine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59093", "l": "[(1->3)-alpha-D-glucosyl](n) + sucrose => [(1->3)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67106", "l": "CO2 + H2O + novofumigatonin + succinate => 2-oxoglutarate + fumigatonoid C + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36652", "l": "8-desmethylnovobiocic acid + S-adenosyl-L-methionine => H(+) + novobiocic acid + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59919", "l": "(2E)-octenal + H2O + NADP(+) <=> (2E)-octenoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45585", "l": "3-hydroxybutanoyl-CoA => (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866851", "l": "CFTR transits to the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20162", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose => myo-inositol + raffinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55429", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.3.6", "l": "\"aureusidin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47478", "l": "(2E)-tetradecenoyl-CoA => (3E)-tetradecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26239", "l": "(2E,6E,10E)-geranylgeraniol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005260", "l": "intracellularly ATP-gated chloride channel activity", "d": ["Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44209", "l": "12-methyltridecanoate + ATP + CoA => 12-methyltridecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.3", "l": "\"thiamine phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404142", "l": "atROL binds RBP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35924", "l": "neamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.24", "l": "\"mitogen-activated protein kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166817", "l": "Cleavage of C3 by C3 convertases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76582", "l": "(2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + 2 H(+) + NADPH <=> (6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45710", "l": "3-dehydrocarnityl-CoA + acetate => 3-dehydrocarnitine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102985", "l": "delta12-fatty-acid desaturase activity", "d": ["Catalysis of the reaction: oleoyl-CoA + O2 + a reduced electron acceptor = linoleoyl-CoA + 2 H2O + an oxidized electron acceptor. This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2214351", "l": "PLK1 phosphorylates GORASP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51679", "l": "[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide <=> [protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5591052", "l": "PROCR binds Protein C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875661", "l": "GGA3 associates with activated MET receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58682", "l": "AH2 + FAD + H(+) => A + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694520", "l": "nsp16 binds VHL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57922", "l": "H(+) + L-asparaginyl-tRNA(Asn) + phosphate => 4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53712", "l": "2 Fe(III)-heme b = beta-hematin", "d": [], "t": []}, {"i": "EC:4.99.1.8", "l": "\"heme ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693783", "l": "NAALADases hydrolyse NAAG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250264", "l": "TXNIP binds reduced thioredoxin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66293", "l": "an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50334", "l": "1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49588", "l": "L-erythrulose 1-phosphate = D-erythrulose 4-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.33", "l": "\"L-erythrulose-1-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706344", "l": "FLT3 phosphorylates GRB10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13429", "l": "2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.60", "l": "\"2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12153", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019147", "l": "(R)-aminopropanol dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD+ = aminoacetone + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691167", "l": "CUL1, SKP1, FBXL5 bind (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56639", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23903", "l": "cis-stilbene oxide + H2O <=> (1R,2R)-hydrobenzoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211191", "l": "Association of DFF with alpha:beta importin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693536", "l": "ATM phosphorylates MDC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157100", "l": "NOTCH3 binds JAG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870686", "l": "BCL2L11 (BIM) gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64719", "l": "NADP(+) + propanal <=> acrolein + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.126", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47179", "l": "(2R)-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9821410", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.4", "l": "\"chloroplast protein-transporting ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034948", "l": "2,6-dihydroxypseudooxynicotine hydrolase activity", "d": ["Catalysis of the reaction: 2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-methylaminobutyrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25458", "l": "diphosphate + gamma-humulene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40084", "l": "hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622377", "l": "CEBPB mRNA is translated to yield CEBPB protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43864", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043959", "l": "L-erythro-3-methylmalyl-CoA lyase activity", "d": ["Catalysis of the reaction: propionyl-CoA + glyoxylate = L-erythro-3-methylmalyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017032", "l": "amino acid:potassium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23790", "l": "acetyl-[citrate lyase ACP] + AMP + diphosphate => acetate + ATP + holo-[citrate lyase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379994", "l": "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67690", "l": "2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate => 2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52875", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate <=> 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33614", "l": "H2O + methyl salicylate <=> H(+) + methanol + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190263", "l": "FGFR3b binds to FGF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13159", "l": "2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH => (R)-glycerate + CO2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022911", "l": "CSPG is secreted (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13222", "l": "(R)-mevalonate + NAD(+) => (R)-mevaldate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24017", "l": "16-epivellosimine + acetyl-CoA => CoA + vinorine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680385", "l": "CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12675", "l": "a nitrile + H2O => an aliphatic amide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.-", "l": "\"With a nitrogenous group as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12652", "l": "L-rhamnofuranose + NAD(+) <=> H(+) + L-rhamnono-1,4-lactone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68881", "l": "ATP + H(+) + NADPH + salicylate => AMP + diphosphate + NADP(+) + salicylaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964759", "l": "Alternative endo-mannosidase I route (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34064", "l": "2-deoxystreptamine + UDP-alpha-D-glucose => 2'-deamino-2'-hydroxyparomamine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140440", "l": "protein-cysteine S-oleoyltransferase activity", "d": ["Catalysis of the transfer of an oleoyl (systematic name, (9Z)-octadecenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]."], "t": []}, {"i": "RHEA:59744", "l": "(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75080", "l": "Formation of AT-AC A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803890", "l": "SFN dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25616", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> terpentedienyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647977", "l": "ICMT methylates S-Farn RAS proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17990", "l": "ATP + L-seryl-[protein] => ADP + H(+) + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38455", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65346", "l": "(2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690740", "l": "CD22 binds B-cell receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62174", "l": "an N-acylethanolamine + phosphate => an N-acylethanolamine phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24262", "l": "2-oxopent-4-enoate + CO2 => (3E)-2-oxohex-3-enedioate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754191", "l": "LEF1 or TCF7 (TCF1), CTNNB1, and TBPL2 (TRF3) bind the TBXT (T, Brachyury) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9752980", "l": "RTP1S:RTP2:underrepresented Olfactory Receptor translocates from the endoplasmic reticulum membrane to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77849", "l": "(2S)-3-(4-hydroxyphenyl)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O2 => N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-tyrosine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51073", "l": "a phenol + an aryl sulfate => a phenol + an aryl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39013", "l": "a triacyl-sn-glycerol(out) => a triacyl-sn-glycerol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44969", "l": "(2E)-tetradecenoyl-CoA + H(+) + NADPH => NADP(+) + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58760", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050590", "l": "desacetoxyvindoline 4-hydroxylase activity", "d": ["Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179293", "l": "UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047830", "l": "D-octopine dehydrogenase activity", "d": ["Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59374", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+) => 1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050138", "l": "nicotinate dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NADP+ + nicotinate = 6-hydroxynicotinate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55305", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23270", "l": "glycine + urea => guanidinoacetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27972", "l": "alpha-D-glucose + D-maltose => D-maltotriose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73363", "l": "beta-alanyl-[peptidyl-carrier protein] + dopamine = beta-alanyl-dopamine + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28420", "l": "(R)-carnitinyl-CoA + 4-(trimethylamino)butanoate => (R)-carnitine + 4-(trimethylamino)butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141423", "l": "Binding of the MCC complex to the APC/C complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11884", "l": "3'-phosphoadenylyl sulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.18", "l": "\"cortisol sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14264", "l": "(E)-sinapoyl-CoA + D-glucono-1,5-lactone <=> 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71099", "l": "androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) = androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002059", "l": "thymine binding", "d": ["Binding to thymine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21269", "l": "(R)-canadine + 2 NADP(+) => berberine + H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76450", "l": "ATP + L-aspartate + L-methionine <=> ADP + H(+) + L-aspartyl-L-methionine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362416", "l": "Frataxin binds iron (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65153", "l": "(2S)-naringenin + UDP-alpha-D-glucose => (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015440", "l": "ABC-type peptide transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40058", "l": "1,2,3-trioctanoylglycerol + H2O <=> 2,3-dioctanoyl-sn-glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158849", "l": "Phenol can form a sulfate conjugate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52709", "l": "GMP + H2O => D-ribose 5-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18327", "l": "(+)-amorpha-4,11-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002058", "l": "uracil binding", "d": ["Binding to uracil."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36346", "l": "2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 <=> 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350486", "l": "DSH binds to FZ at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419843", "l": "CALCA(83-119) binds CALCR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29335", "l": "H2O + L-alanyl-L-glutamate = L-alanine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102373", "l": "uvaol dehydrogenase activity", "d": ["Catalysis of the reaction: uvaol + NADPH + O2 + H+ = ursolic aldehyde + NADP + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755252", "l": "nsp15 cleaves viral poly(U)-RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851079", "l": "p-T,Y MAPK8,9 translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424476", "l": "Activation of RAC1 by VAV2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685608", "l": "CLEC2B binds KLRF1 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48710", "l": "a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71134", "l": "H(+)(in) + L-asparagine(out) + Na(+)(out) <=> H(+)(out) + L-asparagine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52136", "l": "a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.70", "l": "\"guaosine-5'-diphospho-5'-[DNA] diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48764", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) = 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12736", "l": "CO2 + diphosphate + nicotinate beta-D-ribonucleotide <=> 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190258", "l": "FGFR2c binds to FGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78516", "l": "a 5'-end (5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48668", "l": "20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57400", "l": "3-O-acetylpapaveroxine + H2O = acetate + H(+) + narcotine hemiacetal", "d": [], "t": []}, {"i": "EC:3.1.1.105", "l": "\"3-O-acetylpapaveroxine carboxylesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34668", "l": "C30 botryococcene + S-adenosyl-L-methionine => 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18359", "l": "H(+) + NADPH + tropinone => NADP(+) + tropine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39018", "l": "22-oxodocosanoate + H2O + NAD(+) <=> docosanedioate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57173", "l": "(S)-2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66032", "l": "alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56735", "l": "4,4-dihydroxy-all-trans-beta-carotene <=> echinenone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661517", "l": "LUBAC binds OTULIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36995", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15465", "l": "ATP + sphinganine = ADP + H(+) + sphinganine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0120227", "l": "acyl-CoA binding", "d": ["Binding to an acyl-CoA, a thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43263", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204863", "l": "Interaction of Tie2 with Ang2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35130", "l": "L-alanyl-D-glutamate(out) <=> L-alanyl-D-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76128", "l": "3',5'-cyclic AMP(out) + a dicarboxylate(in) => 3',5'-cyclic AMP(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57342", "l": "3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine => 3-hydroxy-L-kynurenine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74923", "l": "a (3R)-3-[(carboxymethyl)amino]fatty acid + H(+) + holo-[ACP] = a (2E)-enoyl-[ACP] + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047909", "l": "galactolipid O-acyltransferase activity", "d": ["Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60157", "l": "ATP + D-galactose(out) + H2O => ADP + D-galactose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63627", "l": "hexadecanoyl-AMP + holo-[ACP] <=> AMP + H(+) + hexadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102988", "l": "9,12-cis-hexadecadienoic acid delta 15 desaturase activity", "d": ["Catalysis of the reaction: (9Z,12Z)-hexadecadienoyl-CoA + O2 + a reduced electron acceptor = 9,12,15-cis-hexadecatrienoyl-CoA + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17186", "l": "IMP + NADP(+) + NH4(+) => GMP + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451283", "l": "kainate receptor binds glutamate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9858590", "l": "DLST transfers glutaryl to CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52267", "l": "3-(aminomethyl)indole + 2 S-adenosyl-L-methionine <=> gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58887", "l": "AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 <=> A + chloramphenicol + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62806", "l": "desertorin A + 2 H2O + NADP(+) => 2 7-demethylsiderin + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65883", "l": "1-hydroxy-5alpha-androstan-3,17-dione + A <=> 5alpha-androstan-1,3,17-trione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25155", "l": "2-oxoglutarate + L-phenylalanine <=> 3-phenylpyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.42", "l": "\"[glycogen-synthase-D] phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.104", "l": "\"steryl-beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804402", "l": "TP53 binds POU4F1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53733", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate => 2-hydroxy-7,8-dihydropteroate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211400", "l": "Anthrax lef cleaves target cell MAP2K3 (MEK3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15205", "l": "a dolichyl diphosphooligosaccharide + H2O = a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.44", "l": "\"oligosaccharide-diphosphodolichol diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54643", "l": "(+)-copalyl diphosphate <=> (12E)-labda-8(17),12,14-triene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49966", "l": "H2O2 + phenazine => 5,10-dihydrophenazine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981610", "l": "Neuroglobin binds oxygen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55969", "l": "(+)-kolavelool + S-adenosyl-L-methionine => (+)-O-methylkolavelool + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61455", "l": "H(+) + NADPH + O2 + oxytetracycline <=> 11a-hydroxy-oxytetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78073", "l": "a 2-acylglycerol + phosphate => a 2-acyl-sn-glycerol 3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78185", "l": "a triacylglycerol + CoA => a 1,2-diacylglycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047963", "l": "glycine N-choloyltransferase activity", "d": ["Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74718", "l": "Internalisation of the insulin receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31158", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) <=> (4S)-4-hydroxy-L-glutamate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36416", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35922", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose <=> H(+) + kanamycin D + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46045", "l": "(3Z)-octenoyl-CoA => (2E)-octenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662618", "l": "MT1G binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78142", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> a 1,3-diacylglycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216282", "l": "Ubiquitinated CI is degraded by the proteasome complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9865579", "l": "MT-CO1 and MT-CO2 complexes associate, installing heme moieties (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110244", "l": "Excision of FapyG by OGG1 glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070579", "l": "5-methylcytosine dioxygenase activity", "d": ["Catalysis of the reaction: 5-methylcytosine (5mC) in DNA + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine (5hmC) in DNA + succinate + CO2. This reaction is the first step in the removal of cytosine methylated on position 5 in double-stranded DNA. This activity can iteratively oxidize 5hmC to 5-formylcytosine (5fC) and to 5-carboxylcytosine (5caC)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416929", "l": "PTGFR binds PGF2a (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47864", "l": "1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67580", "l": "3'-phosphoadenylyl sulfate + tauro-alpha-muricholate = adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73757", "l": "Binding of RRN3 to RNA Polymerase I (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013024", "l": "RHOB binds effectors at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34329", "l": "1,4-benzoquinone + H2O + NADP(+) + nitrite => 4-nitrophenol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60093", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) => 3-dehydro-4alpha-methylzymosterol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23603", "l": "2-oxoglutarate + L-2-aminohexanoate <=> 2-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36697", "l": "desmethyldescarbamoylnovobiocin + dTDP + H(+) => dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10594", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24244", "l": "NADP(+) + pseudotropine = H(+) + NADPH + tropinone", "d": [], "t": []}, {"i": "EC:1.1.1.236", "l": "\"tropinone reductase II\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018655", "l": "2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27684", "l": "ADP + dTTP => ATP + dTDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70967", "l": "IDH3 complex decarboxylates isocitrate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654511", "l": "FGFRL1 dimer binds FGFs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41012", "l": "(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58442", "l": "3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047561", "l": "3-hydroxyanthranilate oxidase activity", "d": ["Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21414", "l": "dihydroxyacetone phosphate + H(+) + NADH => NAD(+) + sn-glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63757", "l": "flavokermesate + UDP-alpha-D-glucose => flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50239", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] <=> 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56679", "l": "dihydroferuloyl-CoA + NADP(+) <=> (E)-feruloyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749590", "l": "ASA- acetylates ALB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649108", "l": "HTR3A pentamer binds 5HT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43955", "l": "3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 <=> H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44450", "l": "a 3-oxoacyl-[ACP] + CO2 + CoA => an acyl-CoA + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36119", "l": "gibberellin A9 + S-adenosyl-L-methionine = O-methyl gibberellin A9 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38217", "l": "6-phospho-D-glucono-1,5-lactone + H(+) + NADH => D-glucose 6-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49250", "l": "galactitol 1-phosphate(in) + L-histidyl-[protein] => galactitol(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626817", "l": "PKC phosphorylates NCF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20190", "l": "5,6-dihydrouracil + NAD(+) => H(+) + NADH + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.53", "l": "\"sialate O-acetylesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950456", "l": "IL12B dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809680", "l": "MTMR12 binds MTM1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41156", "l": "1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42658", "l": "diphthine-[translation elongation factor 2] + H(+) + methanol => diphthine methyl ester-[translation elongation factor 2] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34512", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine => H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647631", "l": "GSDMD (1-275) binds PIPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530573", "l": "CREG(CR1L) binds to surface-bound C3 convertases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26389", "l": "all-trans-beta-carotene + O2 = all-trans-10'-apo-beta-carotenal + beta-ionone", "d": [], "t": []}, {"i": "EC:1.13.11.71", "l": "\"carotenoid-9',10'-cleaving dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57434", "l": "1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20524", "l": "(R)-3-hydroxybutanoate + NAD(+) <=> acetoacetate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33937", "l": "H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide => 2 N(omega)-hydroxy-L-arginine + NADH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73820", "l": "choline(in) + 2 H(+)(out) => choline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9659611", "l": "ANO1 inhibitors bind ANO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132222", "l": "Cleavage of factor B to form classical C3 convertase  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77470", "l": "butan-2-one + hydrogen cyanide <=> 2-hydroxy-2-methylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0000406", "l": "double-strand/single-strand DNA junction binding", "d": ["Binding to a DNA segment that contains double-stranded DNA flanked by a region of single-stranded DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620918", "l": "ASAP1 dimer binds membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42092", "l": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709179", "l": "DPP4 binds DPP4 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17679", "l": "2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+) => 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31887", "l": "(S)-2,3-epoxysqualene = tirucalladienol", "d": [], "t": []}, {"i": "EC:5.4.99.56", "l": "\"tirucalladienol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028525", "l": "NR1H2 or NR1H3, NRIP1 bind the SREBF1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40004", "l": "ent-copalyl diphosphate => (Z)-biformene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78533", "l": "a  beta-D-glucosyll-(1<->1')-sphingoid base + a fatty acid => beta-D-glucosylceramide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110036", "l": "C2 domain binding", "d": ["Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63672", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH = H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14784", "l": "ATP + CoA + heptanedioate <=> 6-carboxyhexanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449855", "l": "IL10 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51550", "l": "(S)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine => (S)-tetrahydropapaverine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2530591", "l": "CREG (CR1L) causes dissociation of C3 convertases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16294", "l": "2-isopropylmaleate + H2O => (2S)-2-isopropylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19533", "l": "2 H(+) + 2 H2O + N(2)-succinyl-L-arginine = CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.3.23", "l": "\"N-succinylarginine dihydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141341", "l": "SMOX-3 oxidises SPN to SPM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727860", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to UBE2I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26083", "l": "(Z)-gamma-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75195", "l": "2-dehydro-3-deoxy-D-arabinonate + NAD(+) = 5-hydroxy-2,4-dioxopentanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183122", "l": "Factor D cleaves C3b-bound Factor B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389839", "l": "39S subunit binds 28S subunit:mRNA:fMet-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66540", "l": "7-dehydrocholesterol + A + H2O = AH2 + cholesta-5,7-dien-3beta,25-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.-", "l": "\"Aspartic endopeptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654167", "l": "Activated FGFR1 binds PLCG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875591", "l": "DOCK7 activates RAC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035402", "l": "histone H3T11 kinase activity", "d": ["Catalysis of the reaction: histone H3-threonine (position 11) + ATP = histone H3-phosphothreonine (position 11) + ADP. This reaction is the addition of a phosphate group to the threonine residue at position 11 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868236", "l": "BAR domain proteins recruit dynamin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807585", "l": "BPI binds LPS on the bacterial surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015654", "l": "tellurite transmembrane transporter activity", "d": ["Enables the transfer of tellurite from one side of a membrane to the other. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450325", "l": "c-FOS activation by phospho ERK1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32459", "l": "2 S-adenosyl-L-methionine + uroporphyrinogen III = H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.107", "l": "\"uroporphyrinogen-III C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805943", "l": "S100A1 binds TLR4:LY96 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937037", "l": "RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654163", "l": "Activated FGFR4 binds PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54306", "l": "n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+) => n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78320", "l": "a III(4)-a-Fuc-Lc4Cer(d18:1(4E)) + GDP-beta-L-fucose => a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28788", "l": "4-hydroxy-L-threonine + ATP => 4-(phosphooxy)-L-threonine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68395", "l": "H2O + peracetic acid <=> acetate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71185", "l": "L-kynurenine(in) + L-tryptophan(out) => L-kynurenine(out) + L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28824", "l": "H(+)(in) + L-galactonate(in) => H(+)(out) + L-galactonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66397", "l": "ATP + cholate(in) + glutathione(in) + H2O => ADP + cholate(out) + glutathione(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848395", "l": "IL18:IL18R1 binds IL18RAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31264", "l": "but-3-ynal + H(+) + pyrroloquinoline quinol => but-3-yn-1-ol + pyrroloquinoline quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78161", "l": "2',3'-cyclophospho-AMP + RNA(n) => RNA(n)-3'-adenine ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61621", "l": "[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose => [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.37", "l": "\"FAD reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49486", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019134", "l": "glucosamine-1-phosphate N-acetyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986940", "l": "MET gene transcription is stimulated by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442715", "l": "Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54243", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60960", "l": "18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose = (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78139", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = a 1,3-diacylglycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48138", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate => a ganglioside GM3 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75139", "l": "4-hydroxyprotoasukamycin + H(+) + NADH + O2 = asukamycin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28981", "l": "H(+)(in) + nitrite(out) => H(+)(out) + nitrite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36890", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34010", "l": "7-dehydrodesmosterol + S-adenosyl-L-methionine <=> 5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619657", "l": "EGR2 and SOX10 bind the PRX gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36826", "l": "1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol <=> CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50348", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] = a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36157", "l": "A + Co-precorrin-4 + S-adenosyl-L-homocysteine => AH2 + Co(II)-factor III + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390438", "l": "FAR2 reduces PalmCoA to HXOL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449829", "l": "IL11 binds IL11RA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56181", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate => 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20796", "l": "aldehydo-D-ribose = D-ribulose", "d": [], "t": []}, {"i": "EC:5.3.1.20", "l": "\"ribose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39656", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46244", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51375", "l": "(9Z)-hexadecenoyl-CoA + glycine <=> CoA + H(+) + N-(9Z-hexadecenoyl)-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9825782", "l": "p-S207 KARS1 dimer binds MITF-M:HINT1 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12447", "l": "hexadecanal + NADP(+) <=> (2E)-hexadecenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29358", "l": "dUMP + H2O <=> 2'-deoxyuridine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13517", "l": "ATP + dTMP = ADP + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729725", "l": "SARS-CoV-2 nsp3 deISGylates ISGylated IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63072", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + orcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55252", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981353", "l": "RASA1 stimulates RAS GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45641", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804099", "l": "HMGB1 binds LTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58867", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944223", "l": "Association of procollagen type V (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62592", "l": "(S)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72671", "l": "eIF5B:GTP is hydrolyzed and released (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44362", "l": "3-hydroxy-2,4-dioxopentyl phosphate => (2S)-2-hydroxy-3,4-dioxopentyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28888", "l": "H(+)(in) + L-serine(in) => H(+)(out) + L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52552", "l": "3-dehydro-L-erythronate + ATP = 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0016312", "l": "inositol bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004456", "l": "phosphogluconate dehydratase activity", "d": ["Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785684", "l": "Fibronectin degradation by CTSG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904599", "l": "advanced glycation end-product binding", "d": ["Binding to advanced glycation end-product."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64118", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350391", "l": "RHO1:GTP binds to activated DAAM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140397", "l": "versiconal hemiacetal acetate esterase activity", "d": ["Catalyzes the reactions: versiconal hemiacetal acetate + H2O = versiconal + acetate, as well as versiconol acetate + H2O = versiconol + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38731", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65941", "l": "(R)-glycerate + GDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990259", "l": "histone H2AQ104 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-glutamine (position 104) = S-adenosyl-L-homocysteine + (histone H2A)-N5-methyl-glutamine (position 104). Note that this corresponds to Q105 in yeast."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58102", "l": "(15Z)-tetracosenoate + glycerol + H(+) => 1-(15Z-tetracosenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237129", "l": "Acireductone is created (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23655", "l": "N-terminal L-glutaminyl-[peptide] <=> N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668831", "l": "CST complex formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018742", "l": "epoxide hydrolase B activity", "d": ["Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9859148", "l": "BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373075", "l": "Metabotropic glutamate receptors bind glutamate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655170", "l": "RCHY1 monoubiquitinates POLH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800298", "l": "HGF dimer binds MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11706", "l": "CO2 + N-(aminomethyl)urea => 2 H(+) + N-(carboxyaminomethyl)urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12081", "l": "acetyl-CoA + H(+) + malonyl-[ACP] => 3-oxobutanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507869", "l": "Aquaporins passively transport glycerol into cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611851", "l": "ADRB2 bind ADR,NAd (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63284", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990538", "l": "xylan O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a xylan= CoA + an acetylated xylan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66401", "l": "ATP + glutathione(in) + glycocholate(in) + H2O => ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35384", "l": "precorrin-6B + S-adenosyl-L-methionine => CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22583", "l": "(S)-4-hydroxy-2-oxopentanoate <=> (2Z)-2-hydroxypenta-2,4-dienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9854415", "l": "ACAT1 tetramer acetylates IDH2 dimer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698008", "l": "FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15662", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside => an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33839", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) = 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.125", "l": "\"7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54146", "l": "5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate => 2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000137", "l": "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74412", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603784", "l": "PEX19:class I PMP binds PEX3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37091", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38295", "l": "(R)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2", "d": [], "t": []}, {"i": "EC:1.1.99.39", "l": "\"D-2-hydroxyglutarate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73213", "l": "H(+)(out) + sucrose(in) => H(+)(in) + sucrose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955712", "l": "SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65884", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine = H2O + L-glutamate + xanthurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40628", "l": "H2O + trihexadecanoylglycerol => 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021945", "l": "MECP2 binds GAMT gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36565", "l": "GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH => GDP-beta-L-colitose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166538", "l": "The bound receptor dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33594", "l": "sphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70692", "l": "ornithine => putrescine + CO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562564", "l": "Caspase-8 processing within TLR4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616110", "l": "EGR1-dependent CDK5R1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45237", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69399", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63288", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72413", "l": "alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O => inulobiose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.18", "l": "\"[myosin light-chain] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23331", "l": "a 9-cis-epoxycarotenoid + O2 <=> 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093332", "l": "p-EPHB phosphorylates SDC2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10085", "l": "3,4-dihydroxybenzoate + O2 => 3-carboxy-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013567", "l": "HES1 gene expression is stimulated by NOTCH3 and STAT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57273", "l": "a 2'-deoxyguanosine in DNA + methylglyoxal => an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73038", "l": "Co(2+)(out) + H(+)(out) <=> Co(2+)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.-", "l": "\"Transferases for other substituted phosphate groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39668", "l": "a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => a ketone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709918", "l": "PTK6 phosphorylates STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68603", "l": "ORC5 binds ORC2:ORC3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25007", "l": "2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase] => L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.174946833339149", "identifiers": [{"i": "GO:0008528", "l": "G protein-coupled peptide receptor activity", "d": ["Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.151", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847534", "l": "RAB43 hydrolyses GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001602", "l": "pancreatic polypeptide receptor activity", "d": ["Combining with pancreatic polypeptide PP to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822117", "l": "NPM2 and HIRA bind p-S9-PRM1:dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50680", "l": "H2O + N-terminal L-glutaminyl-[protein] = N-terminal L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.122", "l": "\"protein N-terminal glutamine amidohydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55126", "l": "5-methylhexanoyl-[ACP] + NAD(+) => (2E)-5-methylhexenoyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43675", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20467", "l": "H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP => [hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351341", "l": "Exocytosis of Proactivator polypeptide (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008919", "l": "lipopolysaccharide glucosyltransferase I activity", "d": ["Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27549", "l": "anthranilate + FADH2 + O2 <=> 3-hydroxyanthranilate + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201457", "l": "BMP2 binds to the receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11432", "l": "S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.153", "l": "\"vitexin 2''-O-rhamnoside 7-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29795", "l": "ATP(in) + H2O(in) + Zn(2+)(out) = ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)", "d": [], "t": []}, {"i": "EC:7.2.2.20", "l": "\"ABC-type Zn(2+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47204", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74218", "l": "H2O + L-seryl-tRNA(Lys) <=> L-serine + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000832", "l": "inositol hexakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9815510", "l": "MIB2 binds CYLD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77502", "l": "2-phenylacetaldehyde + hydrogen cyanide <=> (2S)-2-hydroxy-3-phenylpropanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052858", "l": "peptidyl-lysine acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090595", "l": "acetyl-CoA:L-lysine N6-acetyltransferase", "d": ["Catalysis of the reaction: L-lysine + acetyl-CoA = N6-acetyl-L-lysine + CoA + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434650", "l": "MATEs mediate extrusion of xenobiotics (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65789", "l": "diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39815", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140393", "l": "norsolorinic acid ketoreductase activity", "d": ["Catalysis of the reaction: (1'S)-averantin + NADP+ = norsolorinic acid + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49309", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O => a neolactoside nLc4Cer(d18:0) + L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28361", "l": "FAD + H(+) + tetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0030292", "l": "protein tyrosine kinase inhibitor activity", "d": ["Stops, prevents or reduces the activity of a protein tyrosine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693198", "l": "RHOD binds effectors at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.3.1", "l": "\"beta-galactoside alpha-(2,6)-sialyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690461", "l": "FKBP1A binds tacrolimus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68300", "l": "L-seryl-[protein] + tetradecanoyl-CoA = CoA + O-tetradecanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34217", "l": "4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH => 4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013143", "l": "RAC1 GEFs activate RAC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32372", "l": "all-trans-violaxanthin + 2 L-ascorbate => all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30189", "l": "a quinol + orotate => (S)-dihydroorotate + a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.3", "l": "\"oligonucleotidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46694", "l": "4-hydroxybenzoyl-5'-AMP + diphosphate => 4-hydroxybenzoate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60704", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.-.-", "l": "\"Catalysing the translocation of inorganic cations\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0008253", "l": "5'-nucleotidase activity", "d": ["Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170846", "l": "TGFBR2 recruits TGFBR1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047294", "l": "phosphoglycerol geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: (2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390673", "l": "CHRM2,4 bind acetylcholine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60451", "l": "an S-substituted glutathione + H2O <=> glycine + S-substituted gamma-glutamyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381668", "l": "cAMP activates EPAC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50889", "l": "an N-acylsphingoid base 1-phosphate + H2O => an N-acyl-sphingoid base + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49291", "l": "(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] <=> AMP + diphosphate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49991", "l": "acetone + H(+) + NADPH + O2 <=> H2O + methyl acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78317", "l": "adenosine 5'-tetraphosphate + AMP => ADP + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388596", "l": "Melanocortin receptors bind melanocortins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419351", "l": "PAF receptor binds platelet activating factor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114684", "l": "Phosphorylation of Syntaxin-4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15586", "l": "15-cis-phytoene + 4 A => 4 AH2 + all-trans-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67962", "l": "4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine => 4-amino-L-phenylalanine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22241", "l": "H2O + methylenediurea => N-(carboxyaminomethyl)urea + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78005", "l": "2',3'-c-di-UMP + 2 diphosphate => 2 UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.192", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46959", "l": "hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66303", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose <=> an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38404", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10367", "l": "2-oxoglutarate + dodecanoyl-CoA + H2O <=> (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29014", "l": "2-oxoglutarate(in) + H(+)(in) <=> 2-oxoglutarate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.337", "l": "\"reticuline N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679101", "l": "Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20437", "l": "5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.142", "l": "\"D-pinitol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734713", "l": "ORC6 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56483", "l": "(4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67709", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678327", "l": "MIOX oxidises Ins to GlcA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29607", "l": "H2O + NAD(+) + nitrous oxide = H(+) + NADH + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13278", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate => [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28731", "l": "H(+)(out) + L-leucine(in) = H(+)(in) + L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018547", "l": "nitroglycerin reductase activity", "d": ["Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40360", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853762", "l": "RET dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.366", "l": "\"ginsenoside F1 6-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72978", "l": "2 ATP + 2 indole-3-pyruvate <=> 2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.47", "l": "\"acyl-lipid (9-3)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483174", "l": "PE is methylated to PC by PEMT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23462", "l": "benzyl alcohol + cetraxate + H(+) => benzyl cetraxate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450984", "l": "IDH2 dimer decarboxylates isocitrate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23993", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68905", "l": "3-phenylpropanoate + ATP + H(+) + NADPH => 3-phenylpropanal + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15553", "l": "1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.57", "l": "\"inositol-1,4-bisphosphate 1-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41743", "l": "adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61474", "l": "an N-hexadecanoyl-sphingoid base + CoA + H(+) => a sphingoid base + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853745", "l": "RET binds GFRA1,GFRA3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391913", "l": "FPR2 binds FPR2 ligands (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009488", "l": "IL34 binds CSF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378975", "l": "Follitropin is a heterodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75146", "l": "prosolanapyrone III <=> solanapyrone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49277", "l": "CTP + phytyl phosphate => CDP + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45348", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49279", "l": "CTP + phytyl phosphate <=> CDP + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21898", "l": "adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate => (R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617927", "l": "FOXO4 binds ATXN3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38446", "l": "a fatty acyl-CoA + a long chain fatty alcohol <=> a wax ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78420", "l": "H(+) + N-(1H-1,3-benzodiazol-2-yl)carbamate => 2-aminobenzimidazole + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428231", "l": "ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047029", "l": "(R)-4-hydroxyphenyllactate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + (R)-3-(4-hydroxyphenyl)lactate = NADPH + H+ + 3-(4-hydroxyphenyl)pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388833", "l": "Phosphorylation of CTLA-4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12116", "l": "A + H2 = AH2", "d": [], "t": []}, {"i": "EC:1.12.99.6", "l": "\"hydrogenase (acceptor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187506", "l": "Translocation of p27 to the nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961671", "l": "E2F1 binds the ORC1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45488", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44878", "l": "a 3-acyl-sn-glycerol + a fatty acid + H(+) => a 1,3-diacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73933", "l": "FAD + griseophenone B + H(+) + 2 H2O => chloride + FADH2 + griseophenone C + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205132", "l": "NRAGE activates JNK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29751", "l": "acetoacetate(in) = acetoacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4411383", "l": "NLK phosphorylates TCF/LEF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64188", "l": "an N-(fatty acyl)-L-tyrosine + H2O = a fatty acid + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13745", "l": "ascopyrone M = microthecin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950752", "l": "IL12A:IL12B translocates from Golgi lumen to late endosome lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030780", "l": "12-hydroxydihydrochelirubine 12-O-methyltransferase activity", "d": ["Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73524", "l": "TTP(out) + UTP(in) => TTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77401", "l": "(2S)-2-hydroxyhexanenitrile => hydrogen cyanide + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72569", "l": "dehydroepiandrosterone 3-sulfate(out) + propanoate(in) => dehydroepiandrosterone 3-sulfate(in) + propanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635868", "l": "ub-GLI is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29838", "l": "D-galactonate(in) + H(+)(in) <=> D-galactonate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33982", "l": "DIBOA beta-D-glucoside + H2O <=> D-glucose + DIBOA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.21", "l": "\"glycerol-1-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.154", "l": "\"corrinoid adenosyltransferase EutT\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005463", "l": "UDP-N-acetylgalactosamine transmembrane transporter activity", "d": ["Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9737780", "l": "MTTP binds lomitapide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22683", "l": "dCTP + H(+) + H2O <=> dUTP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61987", "l": "H(+) + NADH + ubiquinone-10 <=> NAD(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839405", "l": "InhibinA-TGFBR3 binding to ACVR2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16881", "l": "hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate", "d": [], "t": []}, {"i": "EC:2.8.1.1", "l": "\"thiosulfate sulfurtransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31885", "l": "delta-amyrin => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52784", "l": "2-sulfenohercynine + AH2 + H(+) = A + ergothioneine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323184", "l": "Defective HLCS does not biotinylate ACACA:Mn2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28392", "l": "N(6)-(D-fructosyl)-L-lysine => N(6)-(D-psicosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59843", "l": "(6S)-5,6,7,8-tetrahydrofolate + syringate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67267", "l": "(2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine <=> (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77647", "l": "(2E,10E)-dode-2,10-dicenoyl-CoA + H(+) + oxaloacetate = [4-(deca-1,8-diyl)-2,5-dioxo-2,5-dihydro-3-furanyl]acetate + CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36293", "l": "formaldehyde + H2O + NADP(+) + xanthine => 3-methylxanthine + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24298", "l": "H(+) + N-carbamoyl-L-aspartate => (S)-dihydroorotate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46920", "l": "(E)-cinnamate + H(+) = CO2 + styrene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29956", "l": "H(+)(in) + thymidine(in) => H(+)(out) + thymidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0032296", "l": "double-stranded RNA-specific ribonuclease activity", "d": ["Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63543", "l": "H2O + neurotensin <=> L-leucine + neurotensin-(1-12)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454916", "l": "The ABCC family mediates organic anion transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51474", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62612", "l": "adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72412", "l": "inulobiose => alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395364", "l": "LTBP4 binds TGF-Beta-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404200", "l": "IGF1,2 binds IGF1R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68336", "l": "(R)-4'-phosphopantetheine sulfonate + H2O = (R)-pantetheine sulfonate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856157", "l": "LAG3 (CD233) binds MHC II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59303", "l": "3'-phosphoadenylyl sulfate + firefly D-luciferin <=> adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37074", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51348", "l": "acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine = 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10694", "l": "H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone => 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25866", "l": "4-acetamidobutanal + H2O2 + propane-1,3-diamine => H2O + N(1)-acetylspermidine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42314", "l": "NADPH + 2 oxidized [adrenodoxin] => H(+) + NADP(+) + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13441", "l": "H2O + L-cysteate = H(+) + NH4(+) + pyruvate + sulfite", "d": [], "t": []}, {"i": "EC:4.4.1.25", "l": "\"L-cysteate sulfo-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44901", "l": "D-galactono-1,4-lactone + H2O => D-galactonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43182", "l": "5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14795", "l": "2-oxoadipate + H(+) + NADH => 2-hydroxyadipate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41344", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004798", "l": "thymidylate kinase activity", "d": ["Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13921", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52899", "l": "2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin <=> 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47135", "l": "11-cis-retinal + H2O + NAD(+) <=> 11-cis-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879273", "l": "mycothiol conjugates with electrophilic xenobiotic (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665871", "l": "ADRM1 binds 26S proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73672", "l": "ADP(out) + diphosphate(in) => ADP(in) + diphosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009227", "l": "IL20 binds to IL22RA1:JAK1:IL20RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70515", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose = 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939205", "l": "ESTG translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11992", "l": "L-pipecolate + O2 = H(+) + H2O2 + L-1-piperideine-6-carboxylate", "d": [], "t": []}, {"i": "EC:1.5.3.7", "l": "\"L-pipecolate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.104", "l": "\"3-dehydro-4-phosphotetronate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70345", "l": "3-chloro-L-tyrosine + NADPH => chloride + L-tyrosine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097604", "l": "temperature-gated cation channel activity", "d": ["Enables the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821931", "l": "BOD1L1 binds SET1A complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419843", "l": "CALCA(83-119) binds CALCR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374701", "l": "Phosphorylation of DCC by Fyn (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806610", "l": "Keratin filament formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71341", "l": "chloride(in) + L-tyrosine(in) + 2 Na(+)(in) => chloride(out) + L-tyrosine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0042577", "l": "lipid phosphatase activity", "d": ["Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38420", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O => 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60075", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 <=> 4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "64.139218015957894", "identifiers": [{"i": "GO:0016627", "l": "oxidoreductase activity, acting on the CH-CH group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033981", "l": "D-dopachrome decarboxylase activity", "d": ["Catalysis of the reaction: D-dopachrome + H+ = 5,6-dihydroxyindole + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31804", "l": "H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose => 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33071", "l": "D-glucose 6-phosphate = 2-deoxy-L-scyllo-inosose + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.124", "l": "\"2-deoxy-scyllo-inosose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.012360833342299", "identifiers": [{"i": "GO:1901265", "l": "nucleoside phosphate binding", "d": ["Binding to nucleoside phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008890", "l": "glycine C-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15358", "l": "5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose => demethyllactenocin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.3", "l": "\"citrate (Re)-synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29829", "l": "Mg(2+)(out) => Mg(2+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23474", "l": "alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose => 2 alpha,alpha'-trehalose 6-mycolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64535", "l": "an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23867", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38779", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76138", "l": "a dicarboxylate(in) + urate(out) <=> a dicarboxylate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47705", "l": "H(+) + iso-precytochalasin + NADPH + O2 => cytochalasin Z16 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948136", "l": "ULK1 Translocates to the mitochondria (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23703", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O <=> (6R)-10-formyltetrahydrofolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44780", "l": "2-demethylmenaquinol-9 + S-adenosyl-L-methionine = H(+) + menaquinol-9 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692408", "l": "NPR2 binds NPPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24806", "l": "(2S)-2-acetolactate + thiamine diphosphate => 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.3.-", "l": "\"Oximinotransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851011", "l": "TRIM27 polyubiquitinates PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800380", "l": "PTPRD binds IL1RAP-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54936", "l": "(2E)-decenoyl-[ACP] + H(+) + NADH = decanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66498", "l": "alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22595", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate <=> (9S,13S,15Z)-12-oxophyto-10-15-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730899", "l": "Oligomerization of BCL10 and MALT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41733", "l": "[(1->4)-alpha-D-glucosyl](n) + phosphate => [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27958", "l": "cytidine + H2O = cytosine + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38095", "l": "gamma-tocotrienol + S-adenosyl-L-methionine = alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37753", "l": "2-methyl-cis-aconitate => 2-methyl-trans-aconitate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432067", "l": "Aquaporin-4 passively transports water out of cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39525", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76029", "l": "(S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate => (S)-reticuline + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36011", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791134", "l": "Expression of SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75467", "l": "ethanolamine(out) + n H(+)(in) = ethanolamine(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71670", "l": "PKM dephosphorylates PEP to PYR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12078", "l": "an aromatic aldehyde + H(+) + NADH => an aromatic primary alcohol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10662", "l": "D-seryl-[protein] => L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9839379", "l": "TGFBR3 binding to FGF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786118", "l": "IL13 binds IL13RA:TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.6", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60755", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone <=> CoA + jasmolin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781905", "l": "ZRANB1 binds APC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39091", "l": "(2E)-decenedioyl-CoA + H2O = (3S)-hydroxydecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73612", "l": "CTP(out) + dCDP(in) => CTP(in) + dCDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9825772", "l": "SIRT1 deacetylates HINT1 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71933", "l": "fumarate(in) + 3 Na(+)(in) => fumarate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50466", "l": "17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+) => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748996", "l": "GST dimers cleave AZA to 6MP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809785", "l": "MTMR2 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59189", "l": "L-histidine => D-histidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070915", "l": "lysophosphatidic acid receptor activity", "d": ["Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102752", "l": "1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)", "d": ["Catalysis of the reaction: a glucosylated glycogenin = a glycogen."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8986972", "l": "IL24 binds IL20RA:JAK1:IL20RB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9860273", "l": "Dimerization of p-S446-IRF5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50788", "l": "NADP(+) + pentan-2-one = (E)-pent-3-en-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679045", "l": "C-ter TLR9 dimer binds HCQ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57253", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GTP => glycolate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62351", "l": "H(+) + NADPH + notoamide E + O2 <=> H2O + NADP(+) + notoamide C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296045", "l": "Activation of Potassium transport channels (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58976", "l": "H2O + malonaldehyde + O2 = 3-oxopropanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29157", "l": "2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in) => 2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2186771", "l": "RNF111 binds SMAD7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19716", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13523", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate => (R)-lactate + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209903", "l": "Noradrenaline is converted to adrenaline (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29944", "l": "2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) => 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10400", "l": "L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.15", "l": "\"glutamine--pyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31080", "l": "3-hydroxyisovaleryl-CoA => 3-methyl-(2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218824", "l": "p-6Y-VEGFR2 binds FYN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36404", "l": "a cholesterol ester + H2O => a fatty acid + cholesterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53059", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034856", "l": "2-hydroxyhexa-2,4-dienoate hydratase activity", "d": ["Catalysis of the reaction: (2E,4E)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.153", "l": "\"adenosine tuberculosinyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25846", "l": "(R)-carvone + H(+) + NADH => (1S,5R)-carveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0015422", "l": "ABC-type oligosaccharide transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67534", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine => (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2172433", "l": "Collagen type XIX degradation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19235", "l": "H(+) + hexadecanoate + L-cysteinyl-[protein] => H2O + S-hexadecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42868", "l": "norspermine + S-adenosyl 3-(methylsulfanyl)propylamine = caldopentamine + 2 H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.5.1.127", "l": "\"caldopentamine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25040", "l": "ATP + L-seryl-tRNA(Sec) <=> ADP + O-phospho-L-seryl-tRNA(Sec)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987043", "l": "IL22RA1 binds JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59563", "l": "H2O + N,N',N''-triacetylchitotriono-1,5-lactone <=> H(+) + N,N',N''-triacetylchitotrionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67344", "l": "kaempferol 7-O-beta-D-glucoside + malonyl-CoA = CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043295", "l": "glutathione binding", "d": ["Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28434", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP] = ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098600", "l": "selenomethionine gamma-lyase activity", "d": ["Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid."], "t": []}, {"i": "REACT:R-HSA-2408537", "l": "Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33635", "l": "ATP + CoA + docosanoate = AMP + diphosphate + docosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33101", "l": "CoA + H(+) + N(1)-acetylspermine => acetyl-CoA + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995334", "l": "COX15 transforms heme O to heme A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141153", "l": "glycerol-3-phosphate dehydrogenase (NADP+) activity", "d": ["NADP+ + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27558", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 2 diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9834076", "l": "PINK1 is autophosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954056", "l": "E2F6 binds TFDP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362522", "l": "ALDHs oxidise atRAL to atRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62362", "l": "(Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+) => FMN-N(5)-peroxide + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473584", "l": "Collagen type III degradation by MMP15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49378", "l": "12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.163", "l": "\"demethylmenaquinone methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.222", "l": "\"2-polyprenyl-6-hydroxyphenol methylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30426", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-delta-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0047146", "l": "sterigmatocystin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-981621", "l": "C3 convertases spontaneously dissociate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28365", "l": "dGTP + H2O <=> dGMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018794", "l": "RHOV binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50605", "l": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990763", "l": "arrestin family protein binding", "d": ["Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799350", "l": "Exocytosis of specific granule membrane proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928640", "l": "PAKs phosphorylate MLC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53128", "l": "delta-carotene = epsilon-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49975", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29702", "l": "dimethyl sulfoxide(in) <=> dimethyl sulfoxide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40694", "l": "1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol <=> 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62271", "l": "(R)-2-hydroxy-3-methylbutyrate + NADP(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001792", "l": "polymeric immunoglobulin receptor activity", "d": ["Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757954", "l": "N4BP1 binds IKBKG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71441", "l": "L-dopa(in) + L-phenylalanine(out) => L-dopa(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59176", "l": "ADP + L-serine = AMP + H(+) + O-phospho-L-serine", "d": [], "t": []}, {"i": "EC:2.7.1.226", "l": "\"L-serine kinase (ADP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375141", "l": "Neogenin:Netrin-3 binds CDO complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53710", "l": "(2E,4Z)-decadienoyl-CoA + H(+) + NADPH => (2E)-decenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52402", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) + NADH => 4-O-phospho-D-threonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63272", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78275", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = delta-araneosene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.215", "l": "\"delta-araneosene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16671", "l": "H(+) + NADH + urate => H2O + NAD(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57533", "l": "a 5'-end ribonucleotide-RNA + ATP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17228", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] <=> 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47540", "l": "7-oxolithocholate + H(+) + NADPH = NADP(+) + ursodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190519", "l": "Internalization of gap junction plaques (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709098", "l": "DHFR dimer reduces FOLA to DHF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57854", "l": "2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase => a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004341", "l": "gluconolactonase activity", "d": ["Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21109", "l": "(S)-3-methyl-2-oxopentanoate + H(+) => 2-methylbutanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842659", "l": "CLIP1(1-1083)-LTK(488-864) fusion dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46570", "l": "5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371590", "l": "HSP70 binds to HSP40:nascent protein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40595", "l": "dodecanedioyl-CoA + H2O = CoA + dodecanedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380782", "l": "STAT binds to the active receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951966", "l": "EP300 acetylates RUNX3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10012", "l": "(R)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2", "d": [], "t": []}, {"i": "EC:1.5.3.6", "l": "\"(R)-6-hydroxynicotine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26259", "l": "dehydroabietadienal + 2 H2O + NADP(+) => dehydroabietadienol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58257", "l": "H2O + O-(ADP-D-ribosyl)-L-seryl-[protein] => ADP-D-ribose + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681616", "l": "AP2 binds chlorpromazine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8963915", "l": "1,25(OH)2D binds VDR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19947", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46887", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67232", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+) = (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0016748", "l": "succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30743", "l": "beta-nicotinamide D-riboside + H2O = D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39053", "l": "ADP + cholesterol(out) + H(+) + phosphate => ATP + cholesterol(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209903", "l": "Noradrenaline is converted to adrenaline (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-217255", "l": "FMO1:FAD N-oxidises TAM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75427", "l": "eburicol + O2 + reduced [NADPH--hemoprotein reductase] = 32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9696266", "l": "RND2 binds effectors (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66040", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71358", "l": "5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) <=> 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57696", "l": "ATP + cob(I)inamide-[corrinoid adenosyltransferase] = adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47574", "l": "a ganglioside GT1b (d18:1(4E)) + CMP + H(+) => a ganglioside GD1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23182", "l": "a ketone + H2O2 => a secondary alcohol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49870", "l": "(+)-dehydrodiconiferyl acid ketone + a quinol => (+)-dehydrodiconiferyl acid + a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77463", "l": "furan-3-carbaldehyde + hydrogen cyanide = (2S)-2-(furan-3-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57375", "l": "H2O + NADPH <=> (6S)-NADPHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18986", "l": "chorismate => isochorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0103016", "l": "tRNA-uridine 2-sulfurtransferase activity", "d": ["Catalysis of the reaction: AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H+ + L-cysteinyl-[protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103089", "l": "methylthiohexylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(6'-methylthio)hexylmalate = 3-(6'-methylthio)hexylmalate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40258", "l": "(2E)-hexadecenedioyl-CoA + H2O <=> (3R)-hydroxyhexadecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019215", "l": "intermediate filament binding", "d": ["Binding to an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168136", "l": "Activated JNKs phosphorylate c-JUN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65022", "l": "CoA + H(+) + N(2)-succinyl-L-ornithine => L-ornithine + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67070", "l": "A + asnovolin J => AH2 + chermesin D methyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36101", "l": "methyl benzoate + S-adenosyl-L-homocysteine => benzoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67468", "l": "H2O + malonyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.9", "l": "\"nitroquinoline-N-oxide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44199", "l": "3-methylundecanoate + ATP + CoA <=> 3-methylundecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9861640", "l": "CTLH E3 ligase ubiquitinates PKM-1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372448", "l": "SLC25A12,13 exchange L-Glu and L-Asp (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54481", "l": "1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72547", "l": "2-oxoglutarate(in) + taurocholate(out) = 2-oxoglutarate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662837", "l": "p-S,T-ADAM17(215-827):Zn2+ cleaves CD163 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16751", "l": "acetate + H(+) + phosphate => H2O + phosphonoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001634", "l": "pituitary adenylate cyclase-activating polypeptide receptor activity", "d": ["A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25983", "l": "(5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71006", "l": "L-histidine(in) + L-phenylalanine(out) <=> L-histidine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.441482309351898", "identifiers": [{"i": "GO:0016684", "l": "oxidoreductase activity, acting on peroxide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.11.-.-", "l": "\"Acting on a peroxide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50484", "l": "acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59254", "l": "(E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA => (E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043960", "l": "L-erythro-3-methylmalyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803946", "l": "TP53 stimulates PLAGL1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.-", "l": "\"Carboxylic ester hydrolases\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839110", "l": "HTRA2 degrades NDUFA13 (GRIM-19) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60804", "l": "2-oxoglutarate + gibberellin A19 + O2 = CO2 + gibberellin A17 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22174", "l": "H(+) + sucrose 6(F)-phosphate + UDP => beta-D-fructose 6-phosphate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14757", "l": "2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone = 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53241", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] => cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400204", "l": "PPARA binds RXRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045486", "l": "naringenin 3-dioxygenase activity", "d": ["Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73249", "l": "H(+) + S-adenosyl-L-homocysteine + salvigenin => ladanein + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18206", "l": "AH2 + O2 + progesterone => 11alpha-hydroxyprogesterone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59663", "l": "D-cellotetraose + O2 <=> D-cellotetraono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863973", "l": "Fusion of ERC and phagosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16461", "l": "ATP + H2O + urate(in) = ADP + H(+) + phosphate + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28736", "l": "H(+)(in) + spermidine(out) => H(+)(out) + spermidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11880", "l": "(S)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2", "d": [], "t": []}, {"i": "EC:1.5.3.5", "l": "\"(S)-6-hydroxynicotine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55062", "l": "a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795147", "l": "Apical excretion of sulfo-Cipro (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46330", "l": "3-phenylpyruvate + NH4(+) => L-threo-3-phenylserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46404", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.25", "l": "\"acyl-lipid omega-3 desaturase (cytochrome b5)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48386", "l": "a 3-hydroxy fatty acid + H2O => a 2,3-saturated fatty acid + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672951", "l": "Inactive RAFs bind YWHAB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10966", "l": "ADP + D-xylulose 5-phosphate + H(+) => ATP + D-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008820", "l": "cobinamide phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H+ = adenosylcobinamide-GDP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57974", "l": "eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10069", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose => 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17226", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] => 6-hydroxynicotinate + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65538", "l": "H(+) + S-adenosyl-L-homocysteine + theacrine => 1,3,7-trimethylurate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031404", "l": "chloride ion binding", "d": ["Binding to a chloride ion (Cl-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75751", "l": "(9Z)-octadecenoate + H2O = 10-hydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72457", "l": "fumarate(in) + 3 H(+)(in) => fumarate(out) + 3 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36805", "l": "genistein + H(+) + H2O => 2-hydroxy-2,3-dihydrogenistein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52120", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12819", "l": "biochanin A + 2 H(+) + NADPH => 2,3-dihydrobiochanin A + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46224", "l": "(E)-feruloyl-CoA + H2O = (E)-ferulate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58396", "l": "4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25623", "l": "tuberculosinyl diphosphate => geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141316", "l": "TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68645", "l": "(2E)-geranyl diphosphate => alpha-thujene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16494", "l": "glycerol 1,2-cyclic phosphate + H2O => glycerol 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102251", "l": "all-trans-beta-apo-10'-carotenal cleavage oxygenase activity", "d": ["Catalysis of the reaction: 10'-apo-beta-carotenal + O2 = 13-apo-beta-carotenone + 4-methylocta-2,4,6-trienedial."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951486", "l": "CD46 binds C4b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59115", "l": "ATP + L-serine <=> ADP + H(+) + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64928", "l": "dADP + H2O = dAMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35361", "l": "(2E)-15-methylhexadecenoyl-CoA + H2O => 3-hydroxyisoheptadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798743", "l": "Exocytosis of secretory granule membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67231", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA <=> (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32084", "l": "CTP + pseudaminate => CMP-pseudaminate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24529", "l": "(R)-lactaldehyde + NAD(+) => H(+) + methylglyoxal + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000319", "l": "BORA binds PLK1 and AURKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45354", "l": "9,10-dihydroxyoctadecanoate => 9,10-epoxyoctadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.132", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53274", "l": "keto-D-tagaturonate => 5-dehydro-L-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73469", "l": "beta-alanine + dopamine => beta-alanyl-dopamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68160", "l": "N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48917", "l": "a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate => a ganglioside GD1c + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12162", "l": "3-dehydro-2-deoxy-D-gluconate + H(+) + NADH => 2-deoxy-D-gluconate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481009", "l": "Exocytosis of platelet dense granule content (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47264", "l": "2,6,10,14-tetramethylpentadecanoate + ATP + CoA = AMP + diphosphate + pristanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33744", "l": "an N-acylsphing-4-enine 1-phosphate + H2O => an N-acylsphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9858321", "l": "DHTKD1 dimer decarboxylates 2-OA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9703895", "l": "CASR binds CASR agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672957", "l": "PP2A dephosphorylates KSR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31400", "l": "all-trans-4,4'-diapophytofluene + FAD + H(+) => all-trans-4,4'-diapo-zeta-carotene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32720", "l": "L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55584", "l": "an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.348", "l": "\"mRNA m(6)A methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022379", "l": "ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73518", "l": "UDP(out) + UTP(in) <=> UDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250280", "l": "ROS oxidize thioredoxin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54890", "l": "AMP + diphosphate + OPC8-CoA => (1S,2S)-OPC-8 + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004166", "l": "dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862300", "l": "LYZ binds bacterial peptidoglycan (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69012", "l": "5beta-dihydrotestosterone + H(+) + NADPH = 5beta-androstane-3beta,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25321", "l": "N-methylethanolamine phosphate + S-adenosyl-L-methionine = H(+) + N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50749", "l": "H2O + juglone => naphthalene-1,2,4,8-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031249", "l": "denatured protein binding", "d": ["Binding to a denatured protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610735", "l": "NUMB binds ITCH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25991", "l": "(5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27827", "l": "hydrogen sulfide + O-succinyl-L-homoserine => L-homocysteine + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62758", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49912", "l": "(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) = (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42138", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60136", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 = a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21432", "l": "(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102529", "l": "apigenin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + apigenin-7-olate = S-adenosyl-L-homocysteine + genkwanin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12115", "l": "indole-3-pyruvate + S-adenosyl-L-methionine <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.43", "l": "\"carboxynorspermidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16152", "l": "beta-nicotinamide D-ribonucleotide + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351894", "l": "Caspase mediated cleavage of BAP31 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48468", "l": "a ganglioside GM1b (d18:1(4E)) + H2O = a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74459", "l": "1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = 1-O-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71368", "l": "epiandrosterone 3-sulfate(out) + 2 Na(+)(out) => epiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76556", "l": "ergosterol + L-aspartyl-tRNA(Asp) => 1-(ergostan-3beta-yl)-L-aspartate + tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419426", "l": "Cannabinoid receptors can bind cannabinoids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71857", "l": "taurochenodeoxycholate(in) => taurochenodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65892", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate = H2O + xanthurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667965", "l": "ANKLE2 binds PP2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9837978", "l": "LONP1 binds mitochondrial inner membrane proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443831", "l": "14-3-3-zeta binds Raf1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35955", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B = 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.118", "l": "\"tryprostatin B 6-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29144", "l": "a ubiquinol + 2 H(+)(in) + nitrate => a ubiquinone + 2 H(+)(out) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015574", "l": "trehalose transmembrane transporter activity", "d": ["Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens."], "t": []}, {"i": "RHEA:17629", "l": "alpha,alpha-trehalose(in) = alpha,alpha-trehalose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29235", "l": "a menaquinone + H(+) + NADH = a menaquinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76936", "l": "2-methylpropan-1-amine + H2O + NAD(+) => 2-methylpropanal + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52705", "l": "H2O + UMP => D-ribose 5-phosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019969", "l": "interleukin-10 binding", "d": ["Binding to interleukin-10."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63549", "l": "angiotensin-(1-9) + H2O => angiotensin-(1-7) + L-phenylalanyl-L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111915", "l": "CAMK4 autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40181", "l": "(2E)-decenoyl-CoA + H2O2 => decanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53374", "l": "H(+) + NADH + uridine(17) in tRNA => 5,6-dihydrouridine(17) in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.38", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0031835", "l": "substance P receptor binding", "d": ["Binding to a substance P receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.188", "l": "\"beta-geranylfarnesene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15638", "l": "[alginate](n) + GDP-alpha-D-mannuronate => [alginate](n+1) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51251", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111237", "l": "Formation of ADAR1 homodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801101", "l": "RABGGTA binds RABGGTB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22602", "l": "acetate + H(+) + N-acetylneuraminate => H2O + N-acetyl-9-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.133", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23660", "l": "4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate", "d": [], "t": []}, {"i": "EC:3.5.2.7", "l": "\"imidazolonepropionase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27943", "l": "(3R)-3-hydroxy-D-aspartate => NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956234", "l": "Translation of DCUN1D3 is inhibited by PUM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30625", "l": "AH2 + all-trans-lycopene => A + all-trans-neurosporene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757256", "l": "MCM3 binds MCM5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34077", "l": "a 1-acyl-sn-glycero-3-phosphate + phosphate => an acyl phosphate + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396009", "l": "STING binds c-di-GMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31617", "l": "dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55166", "l": "H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+) => a jasmonyl-L-isoleucinate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11891", "l": "an aldehyde + H2O + NADP(+) <=> a carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33650", "l": "(9Z)-hexadecenoate + ATP + CoA <=> (9Z)-hexadecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26468", "l": "a menaquinone + H(+) + S-adenosyl-L-homocysteine => a 2-demethylmenaquinone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77471", "l": "hydrogen cyanide + pentan-2-one = (2S)-2-hydroxy-2-methylpentanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11505", "l": "6-demethylsterigmatocystin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + sterigmatocystin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783455", "l": "TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54557", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73898", "l": "ATP + L-glutamate + spermine <=> ADP + gamma-L-glutamylspermine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42300", "l": "a fatty acyl-[ACP] + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.n5", "l": "\"glycerol-3-phosphate acyltransferase (acyl-[acyl-carrier-protein]-transferring)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507869", "l": "Aquaporins passively transport glycerol into cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73070", "l": "an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O <=> an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009403", "l": "SMURF1 polyubiquitinates RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051539", "l": "4 iron, 4 sulfur cluster binding", "d": ["Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375138", "l": "CDO binds BOC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562564", "l": "Caspase-8 processing within TLR4 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46115", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879331", "l": "glucose-6-phosphate is converted to inositol-1-phosphate (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205262", "l": "Direct recruitment of PI3K to p-KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68390", "l": "2 H2O + 2 indole-5,6-quinone-2-carboxylate => 2 5,6-dihydroxyindole-2-carboxylate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170004", "l": "lipoate transmembrane transporter activity", "d": ["Enables the transfer of lipoate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0072496", "l": "Pup transferase activity", "d": ["Catalysis of the transfer of Pup from one protein to another via the reaction X-Pup + Y = Y-Pup + X, where both X-Pup and Y-Pup are covalent linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49352", "l": "2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683672", "l": "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015360", "l": "acetate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018839", "l": "cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity", "d": ["Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9844860", "l": "ST3GAL5 transfers NeuNAc to ceramides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16933", "l": "1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.99.7", "l": "\"1-aminocyclopropane-1-carboxylate deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28682", "l": "3-demethylubiquinol-8 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180591", "l": "Vpu:CD4 associates with beta-TrCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977392", "l": "Expression of CEBPD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665286", "l": "Resistant ERBB2 KD mutants do not bind neratinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35140", "l": "(E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O => CO2 + 2 CoA + demethoxycurcumin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950387", "l": "CANX binds EBI3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955885", "l": "SOCS3 gene expression is inhibited by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109700", "l": "AKT2 binds PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202726", "l": "F11R dimerises (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27781", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) <=> 2-all-trans-octaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43570", "l": "3,6-anhydro-L-galactonate + 2 H(+) + NADH => 3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853405", "l": "TPX2 binds AURKA at centrosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602473", "l": "Autocatalytic activation of MMP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162193", "l": "COQ3 methylates DHDB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733960", "l": "Bile salts and acids dissociate from ALB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634850", "l": "NPAS4 binds ARNT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77361", "l": "5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate => 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62972", "l": "acetyl-CoA + 2 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + orsellinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015196", "l": "L-tryptophan transmembrane transporter activity", "d": ["Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid."], "t": []}, {"i": "REACT:R-HSA-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50997", "l": "L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50336", "l": "O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate = H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0010851", "l": "cyclase regulator activity", "d": ["Binds to and modulates the activity of an enzyme that catalyzes a ring closure reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77372", "l": "[alpha-N-acetylneuraminyl-(2->8)](n)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP-N-acetyl-beta-neuraminate => [alpha-N-acetylneuraminyl-(2->8)](n+1)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62849", "l": "GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70427", "l": "H2O + phenylacetyl-CoA = 2-phenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.106", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110211", "l": "NTHL1 glycosylase mediated recognition and binding of thymine glycol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56347", "l": "a 7-hydroxyisoflavone + UDP-alpha-D-glucose <=> a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654573", "l": "Activated FGFR1 binds SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080030", "l": "methyl indole-3-acetate esterase activity", "d": ["Catalysis of the reaction: methyl indole-3-acetate + H2O = indole-3-acetate + methanol + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727188", "l": "ATP4A:ATP4B binds PPIs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35193", "l": "H2O + norsolorinic acid => noranthrone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71774", "l": "2 Cu(+) + H(+) + NADP(+) <=> 2 Cu(2+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018572", "l": "3,5-dichlorocatechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H+ + 2,4-dichloro-cis,cis-muconate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264622", "l": "Cho is acetylated to AcCho by CHAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73345", "l": "AMP + beta-alanyl-[peptidyl-carrier protein] + H(+) => beta-alanyl-5'-AMP + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13749", "l": "a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP", "d": [], "t": []}, {"i": "EC:2.7.4.10", "l": "\"nucleoside-triphosphate--adenylate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20070", "l": "(Z)-phenylacetaldehyde oxime => H2O + phenylacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58823", "l": "H(+) + malonate + Na(+)(in) <=> acetate + CO2 + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950113", "l": "IL12A binds IL12B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-921155", "l": "p-STAT5 dissociates from the receptor complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008772", "l": "[isocitrate dehydrogenase (NADP+)] kinase activity", "d": ["Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086039", "l": "P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential", "d": ["A calcium-transporting P-type ATPase activity involved in regulation of the plasma membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610723", "l": "GLI proteins bind SUFU (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55131", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] <=> (2E)-5-methylhexenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50797", "l": "glutathione + prostaglandin A2 => prostaglandin A2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76890", "l": "5-hydroxypentan-2-amine + H2O + NAD(+) <=> 5-hydroxypentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65362", "l": "a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74376", "l": "H2O2(out) => H2O2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74641", "l": "AMP(in) + CMP-N-acetyl-beta-neuraminate(out) => AMP(out) + CMP-N-acetyl-beta-neuraminate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32297", "l": "2 diphosphate + NADP(+) + squalene => 2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9609921", "l": "SGTA binds Tail-anchored protein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73831", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13463", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + 2 H2O + NADP(+) => 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-500708", "l": "GRIK3 homomer binds glutamate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13765", "l": "bromochloromethane + H2O = bromide + chloride + formaldehyde + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42668", "l": "L-rhamnofuranose + NADP(+) = H(+) + L-rhamnono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13628", "l": "A + H2O + N(6)-dimethylallyladenine <=> 3-methyl-2-butenal + adenine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64296", "l": "(4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH = (4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52835", "l": "1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35905", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58028", "l": "5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH = a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.295", "l": "\"mycoketide-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23577", "l": "(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] => berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67648", "l": "dATP + H2O = 2'-deoxyadenosine + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43927", "l": "NAD(+) + pregnenolone <=> H(+) + NADH + pregn-5-ene-3,20-dione", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647977", "l": "ICMT methylates S-Farn RAS proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638845", "l": "CERK phosphorylates CERA to form C1P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34507", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate = N,N-diacetyllegionaminate + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.101", "l": "\"N,N'-diacetyllegionaminate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42874", "l": "H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine => N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53713", "l": "2 Fe(III)-heme b => beta-hematin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668831", "l": "CST complex formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18762", "l": "a 1,2-diacyl-sn-glycerol + H2O => a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9822539", "l": "VWF multimer binds to collagen type I (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912790", "l": "CBL binds CRK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22356", "l": "diphosphate + oxaloacetate = CO2 + phosphate + phosphoenolpyruvate", "d": [], "t": []}, {"i": "EC:4.1.1.38", "l": "\"phosphoenolpyruvate carboxykinase (diphosphate)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65990", "l": "calciol => previtamin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.18", "l": "\"exo-alpha-sialidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43597", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 => 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70862", "l": "L-asparagine(in) + L-glutamine(out) + Na(+)(out) <=> L-asparagine(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249386", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389964", "l": "Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77071", "l": "(2E,6E)-farnesyl diphosphate = (1R,4R,5S)-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694721", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187332", "l": "Cytosolic CMs translocate to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549364", "l": "Expression of SERPINE1 (PAI-1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71044", "l": "L-alanine(in) + L-phenylalanine(out) => L-alanine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12342", "l": "H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649393", "l": "ERBB2 KD mutants bind trastuzumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76496", "l": "acetyl-CoA + D-glutamate => CoA + H(+) + N-acetyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30538", "l": "biotinate sulfoxide + H(+) + NADPH <=> biotin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67410", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol => gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54541", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102916", "l": "sesamin synthase activity", "d": ["Catalysis of the reaction: H+ + (+)-piperitol + NADPH + O2 = (+)-sesamin + NADP + 2 H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69053", "l": "RFC binding displaces Pol Alpha (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23625", "l": "a 5,6-dihydrouridine in tRNA + NADP(+) => a uridine in tRNA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75980", "l": "argipressin(out) => argipressin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50196", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75743", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH = 10-hydroxy-(11E)-octadecenoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296045", "l": "Activation of Potassium transport channels (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.38", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798373", "l": "MDM2 ubiquitinates DYRK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23921", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75698", "l": "2'-deoxycytidine(in) <=> 2'-deoxycytidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965446", "l": "WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57108", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849463", "l": "PTK6 phosphorylates SFPQ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34495", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47159", "l": "7alpha,25-dihydroxycholesterol + NAD(+) <=> 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24256", "l": "ATP + kanamycin A = ADP + H(+) + kanamycin 3'-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.95", "l": "\"kanamycin kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9645598", "l": "RRAGC,D hydrolyzes GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71788", "l": "2-oxoadipate + O2 => (R)-2-hydroxyglutarate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67181", "l": "ATP + glycine + L-glutamyl-[protein] => ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77048", "l": "4-phenylbutan-2-amine + H2O + NAD(+) => 4-phenylbutan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783883", "l": "P6C transforms to 2AMAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51418", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2S,3R)-flavan-3-ol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12925", "l": "D-erythrose 4-phosphate + L-lysyl-[protein] = H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56297", "l": "2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] => pyruvate + S-sulfanyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39400", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA => (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44024", "l": "(3R)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63937", "l": "3 a ubiquinone + protoporphyrinogen IX => 3 a ubiquinol + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675790", "l": "MTORC1 dissociates from ULK complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159796", "l": "Furin cleaves pro-factor IX to factor IX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21985", "l": "3'-phosphoadenylyl sulfate + choline => adenosine 3',5'-bisphosphate + choline sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725030", "l": "MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64725", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374723", "l": "Nociceptin receptor binds to nociceptin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18936", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69431", "l": "arsenite + 3 glutathione + H(+) <=> arsenic triglutathione + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72991", "l": "2 Na(+)(out) + scyllo-inositol(out) = 2 Na(+)(in) + scyllo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084912", "l": "Arresten binds integrin alpha1beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37717", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201637", "l": "Caspase-mediated cleavage of plectin-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047970", "l": "guanidinoacetase activity", "d": ["Catalysis of the reaction: guanidinoacetate + H2O = glycine + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086060", "l": "voltage-gated sodium channel activity involved in AV node cell action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3240957", "l": "Formation of PRC2-EZH2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793591", "l": "LIAS synthesizes lipoyl-GCSH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17442", "l": "2-oxoglutarate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33884", "l": "2-deoxy-scyllo-inosamine + NAD(+) => 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140592", "l": "histone H3R8 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 8) = S-adenosyl-L-homocysteine + (histone H3-N-methyl-arginine (position 8). This reaction is the addition of a methyl group to the arginine residue at position 8 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975188", "l": "TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26229", "l": "3 NADP(+) + phytyl diphosphate = geranylgeranyl diphosphate + 3 H(+) + 3 NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.83", "l": "\"geranylgeranyl diphosphate reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050139", "l": "nicotinate-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: nicotinate + UDP-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217209", "l": "Generation of a DNA double strand break (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11558", "l": "3-dehydrocarnitine + H(+) + NADH => (S)-carnitine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679044", "l": "FKBP1A binds sirolimus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46211", "l": "ATP + CoA + eicosanoate <=> AMP + diphosphate + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0016454", "l": "C-palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63326", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48731", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75205", "l": "ADP + alpha,alpha-trehalose(in) + H(+) + phosphate => alpha,alpha-trehalose(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.10", "l": "\"crossover junction endodeoxyribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109701", "l": "PDPK1 binds PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68534", "l": "(Z)-alpha-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617820", "l": "Assembly of IFT B complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28626", "l": "(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693347", "l": "CRYM reduces P2C to PPCA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60511", "l": "a guanosine in mRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77913", "l": "a 2'-deoxyribonucleoside 5'-phosphate + a 3'-end 2'-deoxyribonucleotide-DNA + H(+) => a 3'-end 2'-deoxyribonucleotidyl-deoxyribonucleotide-DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34269", "l": "CoA + fumigaclavine A => acetyl-CoA + fumigaclavine B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0015467", "l": "G-protein activated inward rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force."], "t": []}, {"i": "REACT:R-HSA-1013020", "l": "Activation of GIRK/Kir3 Channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29414", "l": "glycolate(in) + H(+)(in) <=> glycolate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11936", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + trans-resveratrol", "d": [], "t": []}, {"i": "EC:2.3.1.95", "l": "\"trihydroxystilbene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37307", "l": "glycyl-L-asparagine + H2O = glycine + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25430", "l": "ADP + H(+) + N-acetyl-alpha-D-hexosamine 1-phosphate => ATP + N-acetyl-D-hexosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963734", "l": "IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23505", "l": "adenosylcob(III)inamide + H2O => (R)-1-aminopropan-2-ol + adenosylcob(III)yrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603548", "l": "NTRK3(496-641) binds NELFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928620", "l": "PAK1 autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199298", "l": "AKT phosphorylates CREB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191299", "l": "Squalene is oxidized to its epoxide (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706393", "l": "RHOBTB3 binds ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47346", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin] => 7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15154", "l": "4-hydroxybenzoate + UDP-alpha-D-glucose => 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.072032825443515", "identifiers": [{"i": "GO:0019104", "l": "DNA N-glycosylase activity", "d": ["Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5213466", "l": "RIPK3 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33749", "l": "a 1-acyl-sn-glycero-3-phosphate + ADP + H(+) => a 1-acyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11388", "l": "an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.146", "l": "\"11beta-hydroxysteroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852552", "l": "MST1R autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60733", "l": "H2O + NADP(+) + perillyl aldehyde => 2 H(+) + NADPH + perillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47966", "l": "L-histidyl-[protein] + phosphate => H2O + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53838", "l": "a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5229343", "l": "AXIN is phosphorylated in the destruction complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209823", "l": "Tyrosine is hydroxylated to dopa (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67567", "l": "3'-phosphoadenylyl sulfate + chenodeoxycholate <=> adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683774", "l": "p-T68-CHEK2 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66766", "l": "ADP + folate(out) + H(+) + phosphate => ATP + folate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32530", "l": "N,N'-diacetylchitobiose + phosphate <=> N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877187", "l": "P2X7 mediates loss of intracellular K+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371527", "l": "HSF1 trimer translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9843978", "l": "CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162188", "l": "COQ5 methylates MDMQ10H2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22062", "l": "2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] => (4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21577", "l": "carnitine + H(+) => 2-methylcholine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190256", "l": "FGFR1c binds to FGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399712", "l": "Activation of Ca permeable AMPA receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050404", "l": "zeatin O-beta-D-xylosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-xylose + zeatin = O-beta-D-xylosylzeatin + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085318", "l": "SUMOylation of NCOA2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665284", "l": "Resistant ERBB2 KD mutants do not bind lapatinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649856", "l": "Oxidative damage to the AP site (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0034327", "l": "hexanoyltransferase activity", "d": ["Catalysis of the transfer of a hexanoyl (CH3-[CH2]4-CO-) group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029690", "l": "Caspase-6 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17393", "l": "3-maleylpyruvate = 3-fumarylpyruvate", "d": [], "t": []}, {"i": "EC:5.2.1.4", "l": "\"maleylpyruvate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42997", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (R)-cembrene A + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28366", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate = beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.180", "l": "\"lipopolysaccharide N-acetylmannosaminouronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31600", "l": "FMNH2 + NADH + O2 + thymine => (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429529", "l": "Thrombin binding to GP1b:IX:V (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034900", "l": "3-(N-formyl)-formiminopyruvate hydrolase activity", "d": ["Catalysis of the reaction: 3-(N-formyl)-formiminopyruvate + H2O = 3-formiminopyruvate + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39601", "l": "(3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+) => 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047315", "l": "kynurenine-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66141", "l": "acetyl-CoA + octopamine => CoA + H(+) + N-acetyloctopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10353", "l": "an N-acetylarylalkylamine + H2O => acetate + an aralkylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14470", "l": "2-aminomuconate 6-semialdehyde + H2O + NAD(+) => (2Z,4E)-2-aminomuconate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33497", "l": "3-heptaprenyl-sn-glycero-1-phosphate + diphosphate => all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772430", "l": "CTNNBIP1 binds beta-catenin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730856", "l": "Autophosphorylation of PAK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51061", "l": "5alpha-androst-1-ene-3,17-dione + A => AH2 + androsta-1,4-diene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168934", "l": "MAVS interacts with RIPK1 and FADD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.191", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29268", "l": "L-valine(in) + Na(+)(in) => L-valine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23748", "l": "ATP + GTP = diphosphate + pppGp(2'-5')A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632914", "l": "TP53 binds the GLS2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61302", "l": "acetaldehyde + dihydroxyacetone phosphate => 5-deoxy-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37262", "l": "(2S)-2-aminobutanoate + H2O + NAD(+) <=> 2-oxobutanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817575", "l": "ERO1B oxidizes P4HB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22331", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) <=> diphosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47235", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001760", "l": "aminocarboxymuconate-semialdehyde decarboxylase activity", "d": ["Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H+ = 2-aminomuconate 6-semialdehyde + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66349", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A => (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30677", "l": "H2O + squalene => tetrahymanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798044", "l": "BTG2 binds CCR4-NOT complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10838", "l": "demethylsulochrin + NADP(+) => NADPH + O2 + questin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59075", "l": "AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate) + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106283", "l": "ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + ursodeoxycholate = 7-oxolithocholate + H+ + NADH."], "t": []}, {"i": "RHEA:42028", "l": "NAD(+) + ursodeoxycholate = 7-oxolithocholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189062", "l": "lactose + H2O => D-glucose + D-galactose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727349", "l": "XDH dehydrogenates xanthine to form urate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669859", "l": "Imatinib-resistant KIT mutants do not bind imatinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37595", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68362", "l": "dehydro-L-arabinono-1,4-lactone + H(+) + H2O2 => L-xylono-1,4-lactone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37633", "l": "1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12642", "l": "(2R)-3-phosphoglycerate + NAD(+) => 3-phosphooxypyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213239", "l": "Formation of MHC II alpha beta heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55999", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43799", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404142", "l": "atROL binds RBP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37814", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16102", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate => n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990162", "l": "histone H3K4 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 4) + H2O = histone H3 L-lysine (position 4) + acetate. This reaction represents the removal of an acetyl group from lysine at position 4 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112430", "l": "Formation of P-TEFb complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65782", "l": "3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669158", "l": "NF2 binds PAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60889", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O => (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35631", "l": "cyanidin + UDP-alpha-D-galactose = cyanidin 3-O-beta-D-galactoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.294", "l": "\"cyanidin 3-O-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917700", "l": "MVB Vesicle Formation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23875", "l": "(R)-propane-1,2-diol + NAD(+) <=> (R)-lactaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40059", "l": "decanoyl-CoA + H2O = CoA + decanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75547", "l": "2 (3R)-3-isocyanylbutanoyl-[ACP] + ATP + L-lysine + 2 NADPH = (2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + AMP + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-383190", "l": "HCO3- transport through ion channel (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.356", "l": "\"GDP-L-colitose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64000", "l": "(4R)-hydroxysphinganine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16422", "l": "an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66965", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61968", "l": "a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062188", "l": "anandamide 11,12 epoxidase activity", "d": ["Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]."], "t": []}, {"i": "RHEA:53144", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62466", "l": "2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211968", "l": "CYP2W1 oxidises INDOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62378", "l": "(S)-lactate + H(+) + pyruvate => 2,4-didehydro-3-deoxy-L-rhamnonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "52.219369753541194", "identifiers": [{"i": "GO:0015276", "l": "ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247836", "l": "Retromer recycles WLS to the Golgi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27444", "l": "NAD(+) + xylitol <=> D-xylose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000515", "l": "aspartate:glutamate, proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-aspartate(in) + L-glutamate(out) = H+(in) + L-aspartate(out) + L-glutamate(in)."], "t": []}, {"i": "RHEA:70783", "l": "H(+)(out) + L-aspartate(in) + L-glutamate(out) = H(+)(in) + L-aspartate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042961", "l": "ATPase-coupled antimonite transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58045", "l": "a long-chain fatty acyl-CoA + alpha,alpha-trehalose => 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168880", "l": "vRNP Export through the nuclear pore (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33153", "l": "(R)-S(6)-acetyldihydrolipoamide + CoA => (R)-dihydrolipoamide + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043336", "l": "site-specific telomere resolvase activity", "d": ["Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69175", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] <=> (2E)-2-butenoate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43399", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.26", "l": "\"[tau protein] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417825", "l": "P2Y11 receptor can bind to ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033459", "l": "GAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GAA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62359", "l": "8-oxo-GDP + H2O <=> 8-oxo-GMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40960", "l": "2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433501", "l": "Interaction of other adapter proteins with p-KIT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47750", "l": "a ubiquinol + n Na(+)(out) + NAD(+) => a ubiquinone + H(+) + n Na(+)(in) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71155", "l": "TAT deaminates tyrosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.354970481220079", "identifiers": [{"i": "GO:0004030", "l": "aldehyde dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75070", "l": "chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in) <=> chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202307", "l": "Change of PKC theta conformation (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40967", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60831", "l": "a 5'-end triphospho-adenosine in mRNA + H2O <=> a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626753", "l": "H2O2 oxidizes Cys residues to form Cys-sulfenic acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38198", "l": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164840", "l": "ADP and Pi bind to ATPase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13031", "l": "H(+) + H2O2 + N-acetyl-D-glucosaminate => H2O + N-acetyl-D-glucosamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47449", "l": "(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55428", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.60", "l": "\"ferruginol monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10723", "l": "2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16432", "l": "ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59090", "l": "(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine => D-histidine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35510", "l": "30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16001", "l": "H(+) + H2O + N(6)-methyl-AMP = IMP + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130619", "l": "TGN-lysosomal vesicle coat assembly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39581", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167150", "l": "Resumption of elongation of HIV-1 transcript after recovery from pausing (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72972", "l": "5-oxo-L-proline(out) + 2 Na(+)(out) => 5-oxo-L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18008", "l": "D-threitol + NADP(+) <=> D-erythrulose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350385", "l": "DSH binds to RAC1:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73718", "l": "UBF-1 Binds rDNA Promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68514", "l": "alpha-acoradiene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59797", "l": "dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0004308", "l": "exo-alpha-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38438", "l": "(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12773", "l": "2-oxoglutarate + O2 + proclavaminate = CO2 + dihydroclavaminate + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031843", "l": "type 2 neuropeptide Y receptor binding", "d": ["Binding to a type 2 neuropeptide Y receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036025", "l": "Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)5 (PP-Dol)1 by ALG3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.52", "l": "\"peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31238", "l": "(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate <=> (4R)-4-hydroxy-2-oxoglutarate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53921", "l": "ATP + L-threonyl-[Fas-activated protein] => ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58916", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene = (S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176298", "l": "Activation of claspin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71420", "l": "3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in) => 3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358789", "l": "Self-ubiquitination of RNF41 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62647", "l": "(5Z,8Z)-eicosadienoate + O2 <=> (5S)-hydroperoxy-(6E,8Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036400", "l": "short neuropeptide F receptor activity", "d": ["Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051722", "l": "protein C-terminal methylesterase activity", "d": ["Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21770", "l": "H(+) + methylamine + NADPH + pyruvate => H2O + N-methyl-L-alanine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709454", "l": "EPOR binds EPOR agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77660", "l": "phomoidride A + S-adenosyl-L-methionine => (-)-phomoidride B + H(+) + methanol + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54954", "l": "AMP + diphosphate + nonanoyl-CoA => ATP + CoA + nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23334", "l": "(2R)-3-phospho-glyceroyl phosphate + GDP => (2R)-3-phosphoglycerate + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465940", "l": "atRAL is reduced to atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784765", "l": "p-Y705-STAT3 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53731", "l": "H2O + N-acetyl-D-muramate 6-phosphate <=> N-acetyl-D-muramate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047089", "l": "dihydrochelirubine 12-monooxygenase activity", "d": ["Catalysis of the reaction: dihydrochelirubine + H+ + NADPH + O2 = 12-hydroxydihydrochelirubine + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13180", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate <=> 3-oxopropanoate + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193832", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781953", "l": "YOD1 binds VCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58738", "l": "5-methyl-UMP + diphosphate + H(+) => H2O + TTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58830", "l": "9R,10R-dihydroxyoctadecanoate => (9S,10R)-epoxy-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.54", "l": "\"lytic cellulose monooxygenase (C1-hydroxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168875", "l": "Trimerization of HA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708557", "l": "FBXL17 binds BACH1:MAFK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917987", "l": "TFRC dimer binds 2xholoTF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9825754", "l": "HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061730", "l": "C-rich strand telomeric DNA binding", "d": ["Binding to C-rich, single-stranded, telomere-associated DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12938", "l": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51165", "l": "cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031880", "l": "type 3 somatostatin receptor binding", "d": ["Binding to a type 3 somatostatin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928604", "l": "SFKs phosphorylate VAV2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6794347", "l": "Homer1,2,3 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51031", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 <=> 7-chloroindole-3-pyruvate imine dimer + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36522", "l": "H(+) + hexacosanoyl-CoA + malonyl-CoA <=> 3-oxooctacosanyol-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63342", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034814", "l": "NTRK3 phosphorylates PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759158", "l": "SQSTM1 oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004664", "l": "prephenate dehydratase activity", "d": ["Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602186", "l": "Defective CYP27B1 does not hydroxylate CDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0090681", "l": "GPCR taste receptor activity", "d": ["A G protein-coupled receptor activity that is responsible for the sense of taste."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032406", "l": "MutLbeta complex binding", "d": ["Binding to a MutLbeta mismatch repair complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21670", "l": "ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in) => ATP + H2O + sn-glycerol 3-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437118", "l": "GPVI stimulates PI3K beta, gamma (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247922", "l": "GGCT transforms gGluCys to OPRO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50869", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 => (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38318", "l": "chorismate <=> 3-hydroxybenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64226", "l": "5-hydroxyuridine(34) in tRNA + A + H2O => AH2 + O2 + uridine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362485", "l": "GHBP binds GH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186785", "l": "PDGF-AA clevage by Furin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19151", "l": "H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide => L-arginyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33396", "l": "H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester => GMP + N(alpha)-acetyl-L-lysine methyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74119", "l": "delphinidin + UDP-alpha-D-galactose = delphinidin 3-O-beta-D-galactoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67168", "l": "2-oxoglutarate + 3-hydroxy-L-phenylalanine = 3-(3-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940100", "l": "CDK1 phosphorylates VCPIP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66882", "l": "10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855232", "l": "RELN:VLDLR binds DAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852200", "l": "Inactivation of LCK by PTPN22 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021068", "l": "PalmS-ESRs bind CAVs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54771", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine <=> [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432010", "l": "Aquaporin-1 passively transports water into cell (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6790038", "l": "Expression of HSP90B1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047182", "l": "alcohol O-cinnamoyltransferase activity", "d": ["Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624800", "l": "CDK1 phosphorylates LBR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22678", "l": "7(1)-hydroxychlorophyllide a + H2O + NADP(+) => chlorophyllide a + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26516", "l": "6-oxohexanoate + H(+) => cyclohexan-1,2-dione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51864", "l": "(2E)-geranyl diphosphate + esculetin = 8-geranylesculetin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53358", "l": "H(+) + NADPH + uridine(20b) in tRNA => 5,6-dihydrouridine(20b) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805109", "l": "CDK2 phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33681", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14110", "l": "L-proline + NADP(+) => 1-pyrroline-5-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71930", "l": "2 Na(+)(out) + tauroursodeoxycholate(out) <=> 2 Na(+)(in) + tauroursodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139893", "l": "Granzyme-B activates BID by cleavage (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109700", "l": "AKT2 binds PIP3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12495", "l": "L-methionine <=> D-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28441", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP] <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63862", "l": "(2R,9Z,12Z)-2-hydroperoxyoctadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75663", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate = 10,11-epoxy-12-hydroxy-(14Z)-eicosenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78579", "l": "(3R)-hydroxydocosanoyl-CoA + NAD(+) = 3-oxodocosanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66820", "l": "ATP + H2O + Mn(2+)(in) = ADP + H(+) + Mn(2+)(out) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.22", "l": "\"P-type Mn(2+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199203", "l": "PANK1/3 phosphorylate PanK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741395", "l": "CARD9 binds RIP2 (and NOD2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160138", "l": "23S rRNA pseudouridine(2604) synthase activity", "d": ["Catalysis of the reaction: uridine(2604) in 23S rRNA = pseudouridine(2604) in 23S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684836", "l": "CLEC1B dimer binds PDPN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004382", "l": "GDP phosphatase activity", "d": ["Catalysis of the reaction: GDP + H2O = GMP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18083", "l": "diphosphate + pentalenene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449117", "l": "TXLNA (IL14) binds syntaxin1A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14451", "l": "3,8-divinyl chlorophyllide a + H(+) + NADPH => chlorophyllide a + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938328", "l": "RUNX1:CBFB binds the NFE2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57053", "l": "3-oxoisoapionate + H(+) => CO2 + L-erythrulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52661", "l": "an L-alpha-amino acid + ATP + holo-[ACP] => AMP + an L-alpha-aminoacyl-[ACP] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13506", "l": "choline + O2 => betaine aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58982", "l": "3,7-dimethylocta-2,6-dienoate + H(+) + H2O2 => citral + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48246", "l": "a ganglioside GM1b + CMP + H(+) => a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43109", "l": "2 Fe(III)-[cytochrome c] + H2O + N2 => 2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443418", "l": "GP1b signaling involves c-Src (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0051731", "l": "polynucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851011", "l": "TRIM27 polyubiquitinates PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956639", "l": "RUNX1 binds YAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021412", "l": "PBX1 gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690152", "l": "USP5 cleaves polyubiquitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26519", "l": "3-hydroxypropanoyl-CoA => acryloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78835", "l": "3''-dehydropuerarin = 1,5-anhydro-D-erythro-hex-1-en-3-ulose + daidzein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38162", "l": "(2S,3S)-hydroxyarginine <=> (2S,3R)-capreomycidine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807144", "l": "HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047922", "l": "gentisate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5213466", "l": "RIPK3 is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55689", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O => 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31531", "l": "2-oxoglutarate + L-arginine + O2 = CO2 + N(omega)-hydroxy-L-arginine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59977", "l": "2-phenylacetate + H(+) => CO2 + toluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63726", "l": "candesartan O-beta-D-glucuronoside + UDP => candesartan + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114671", "l": "vWF binds to collagen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16837", "l": "5'-acylphosphoadenosine + H2O = a carboxylate + AMP + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.20", "l": "\"5'-acylphosphoadenosine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49875", "l": "(+)-dehydrodiconiferyl acid ketone + a quinone + H2O <=> (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22644", "l": "O2 + protopine + reduced [NADPH--hemoprotein reductase] = 6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.98", "l": "\"protopine 6-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63791", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28342", "l": "dITP + H2O = dIMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76178", "l": "glycyl-L-glutamate(out) + 3 H(+)(out) <=> glycyl-L-glutamate(in) + 3 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9623384", "l": "α1-agonists bind ADRA1A,B,D (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008507", "l": "sodium:iodide symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25313", "l": "glyoxylate + H2O2 => glycolate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60700", "l": "a 1-acyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204863", "l": "Interaction of Tie2 with Ang2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63204", "l": "H2O + octadecanoyl-[ACP] = H(+) + holo-[ACP] + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000342", "l": "RNA cap 4 binding", "d": ["Binding to a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.135", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099038", "l": "ceramide floppase activity", "d": ["Catalysis of the movement of ceramide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66566", "l": "5-histaminyl-L-glutamyl-[protein] + NH4(+) => histamine + L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.33", "l": "\"fruit bromelain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51924", "l": "AH2 + menaquinone-9 = A + beta-dihydromenaquinone-9", "d": [], "t": []}, {"i": "EC:1.3.99.38", "l": "\"menaquinone-9beta-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37486", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine <=> 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77922", "l": "a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA + H2O <=> 2-deoxy-D-ribose 5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49629", "l": "acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine => 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167468", "l": "Abortive HIV-1 Initiation After Second Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43418", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14621", "l": "(S)-2,3-epoxysqualene = lanosterol", "d": [], "t": []}, {"i": "EC:5.4.99.7", "l": "\"lanosterol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013147", "l": "RAC1 GDIs block activation of RAC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35445", "l": "an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP => an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69270", "l": "an alkenyl isothiocyanate + sulfate => a (Z)-N-(sulfonatooxy)alkenimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19173", "l": "H(+) + NADH + naphthalene + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.12", "l": "\"naphthalene 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31539", "l": "(2S)-naringenin + S-adenosyl-L-methionine = (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.232", "l": "\"naringenin 7-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21125", "l": "cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39480", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12436", "l": "(E)-caffeoyl-CoA + putrescine = CoA + H(+) + N-caffeoylputrescine", "d": [], "t": []}, {"i": "EC:2.3.1.138", "l": "\"putrescine N-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9007926", "l": "ATRX binds DAXX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25243", "l": "(S)-ureidoglycolate + NH4(+) => (S)-2-ureidoglycine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17747", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP => N-acetyl-D-glucosamine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1500804", "l": "Peroxynitrite is reduced by AhpE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66575", "l": "2-naphthol + 3'-phosphoadenylyl sulfate <=> 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35758", "l": "NAD(+) + UDP-alpha-D-glucose <=> H(+) + NADH + UDP-3-oxo-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167408", "l": "The high affinity receptor complex binds to G-protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705082", "l": "SARS-CoV-2 nsp13 binds TBK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420661", "l": "Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052685", "l": "perillic acid-CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP + phosphate + perillyl-CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.24", "l": "\"(E3-independent) E2 ubiquitin-conjugating enzyme\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64250", "l": "CoA + H(+) + N-decanoylglycine => decanoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33005", "l": "(+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56725", "l": "AH2 + all-trans-beta-carotene + O2 => 4-hydroxy-all-trans-beta-carotene + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75102", "l": "(4Z,15Z)-bilirubin IXalpha + UDP-alpha-D-glucuronate <=> (4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047329", "l": "phosphoramidate-hexose phosphotransferase activity", "d": ["Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41282", "l": "H2O + N-octadecanoylsphing-4-enine <=> octadecanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983153", "l": "E1 mediated ubiquitin activation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10055", "l": "(R)-2-hydroxy-4-methylpentanoate + NAD(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78774", "l": "3''-dehydroisoorientin <=> 1,5-anhydro-D-erythro-hex-1-en-3-ulose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677050", "l": "Formation of the GCN5-ATAC complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23298", "l": "N-acetyl-D-mannosamine + pyruvate => aceneuramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35460", "l": "cholesterol + NAD(+) => cholest-5-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53160", "l": "H2O + N-acyl-sn-glycero-3-phosphoethanolamine = an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45024", "l": "cholesterol + H(+) + NADPH + O2 = 7-dehydrocholesterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20124", "l": "ATP + L-glutamine + tRNA(Gln) <=> AMP + diphosphate + L-glutaminyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29833", "l": "Ni(2+)(out) => Ni(2+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17055", "l": "beta-D-fructose 6-phosphate + D-erythrose 4-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836275", "l": "TFAP2A binds TFAP2B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24956", "l": "H2O + N-acetyl-beta-D-muramate 6-phosphate = (R)-lactate + N-acetyl-beta-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35689", "l": "3-oxotetradecasphinganine + H(+) + NADPH => NADP(+) + tetradecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44368", "l": "Cr(6+) + 2 NADPH + O2 = Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73808", "l": "GDP + S-adenosyl-L-methionine => N(7)-methyl-GDP + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983142", "l": "Formation of peptide loading complex (PLC) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112042", "l": "Opioid binds MOR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29966", "l": "H(+)(in) + inosine(in) <=> H(+)(out) + inosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35921", "l": "H(+) + kanamycin D + UDP => 2'-deamino-2'-hydroxyneamine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51701", "l": "S-adenosyl-L-methionine + xanthogalenol => 4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62187", "l": "peregrinol diphosphate <=> diphosphate + labd-13(16),14-diene-9-ol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989777", "l": "Expression of RGL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37691", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24187", "l": "4,5-dihydroxyphthalate + H(+) <=> 3,4-dihydroxybenzoate + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19686", "l": "(E)-feruloyl-CoA + tyramine => CoA + H(+) + N-[(E)-feruloyl]tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53900", "l": "ATP + L-threonyl-[myosin light chain] = ADP + H(+) + O-phospho-L-threonyl-[myosin light chain]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73719", "l": "3,4-dihydroxybenzoate + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + vanillate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31955", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22834", "l": "N-formyl-L-glutamate + NH4(+) => H2O + N-formimidoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65127", "l": "benzoyl-CoA + ethanol <=> benzyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446694", "l": "IRAK4 phosphorylates IRAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21807", "l": "ATP + myo-inositol <=> 1D-myo-inositol 3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74077", "l": "NAD(+) + phylloquinol => H(+) + NADH + phylloquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70613", "l": "GOT2 transaminates OA and L-Glu (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18095", "l": "H(+) + NADPH + uracil => 5,6-dihydrouracil + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114683", "l": "Phosphorylation of Platelet Sec-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316349", "l": "RALA:GTP binds MYO1C:CALM1 and activates MYO1C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66436", "l": "NADP(+) + pentan-3-one = H(+) + NADPH + pent-1-en-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45090", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0016752", "l": "sinapoyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75890", "l": "ADP-1-deoxy-1,O(4)-didehydro-D-ribose + L-arginyl-[protein] <=> ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46025", "l": "H2O2 + tetradecanoate => (3R)-hydroxytetradecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865275", "l": "PDGF-BB clevage by Furin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14726", "l": "2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031842", "l": "type 1 neuropeptide Y receptor binding", "d": ["Binding to a type 1 neuropeptide Y receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68423", "l": "cis-(homo)3aconitate + H2O <=> (2R,3S)-iso(homo)3citrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34051", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H2O = 6'''-deamino-6'''-hydroxyneomycin C + acetate", "d": [], "t": []}, {"i": "EC:3.5.1.113", "l": "\"2'''-acetyl-6'''-hydroxyneomycin C deacetylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700175", "l": "Active ALK phosphorylates SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15674", "l": "acetoacetyl-CoA + H2O => acetoacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050038", "l": "L-xylulose reductase (NADPH) activity", "d": ["Catalysis of the reaction: NADP+ + xylitol = L-xylulose + H+ + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033464", "l": "GGG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GGG codon."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11478", "l": "glycerol + phosphate => glycerol 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11661", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O => acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834897", "l": "Expression of MSX1 in the neural plate border (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29783", "l": "ATP + H2O + L-cysteine(in) = ADP + H(+) + L-cysteine(out) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64659", "l": "(E)-sinapaldehyde + CoA + NADP(+) <=> (E)-sinapoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27870", "l": "(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.13", "l": "\"2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10160", "l": "L-iditol + NAD(+) = H(+) + keto-L-sorbose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9648268", "l": "HTR1A binds HTR1A antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37492", "l": "4-coumaroyl-CoA + S-adenosyl-L-methionine => CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64313", "l": "2 chloride + 2 FADH2 + 2 O2 + sulochrin => dihydrogeodin + 2 FAD + H(+) + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55861", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74723", "l": "isorhamnetin + S-adenosyl-L-methionine = 3',4'-O-dimethylquercetin + 2 H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72536", "l": "H2O + NADP(+) + vanillin => 2 H(+) + NADPH + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029453", "l": "Phosphorylation of VAV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32041", "l": "AMP + ATP + 2 H(+) => H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65109", "l": "aculene C + L-prolyl-[peptidyl-carrier protein] => aculene A + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74955", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + holo-[ACP] = a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865276", "l": "PDGF-AB clevage by Furin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809010", "l": "COPI vesicle uncoating (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21054", "l": "2-oxopropyl-coenzyme M + H(+) + NADH => (S)-2-hydroxypropyl-coenzyme M + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20346", "l": "[thioredoxin]-dithiol + NADP(+) => [thioredoxin]-disulfide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56245", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] => 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34539", "l": "S-adenosyl-L-methionine + tellurite = methanetellurite + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.265", "l": "\"tellurite methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60952", "l": "(E)-5-hydroxyferulate + S-adenosyl-L-methionine = (E)-sinapate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77765", "l": "a 3'-end ribonucleotide-RNA + a ribonucleoside 5'-phosphate + H(+) => a 3'-end ribonucleotidyl-ribonucleotide-RNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22765", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44560", "l": "4-hydroxybenzoate + all-trans-heptaprenyl diphosphate = 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16198", "l": "(3S)-3-hydroxybutanoyl-CoA + NADP(+) => acetoacetyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16301", "l": "H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16190", "l": "3-(4-hydroxyphenyl)pyruvate + O2 => CO2 + homogentisate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19256", "l": "a sphingomyelin + H2O <=> an N-acylsphing-4-enine + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70971", "l": "ACO2 isomerizes citrate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24157", "l": "2-methylpropanoate + ATP => 2-methylpropanoyl phosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811454", "l": "MAPKs phosphorylate PP2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805470", "l": "AMPK phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008692", "l": "3-hydroxybutyryl-CoA epimerase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24111", "l": "H2O + N-methyl-2-oxoglutaramate <=> 2-oxoglutarate + methylamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76037", "l": "2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + protopine => (S)-cis-N-methylstylopine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20321", "l": "L-proline + NAD(+) = 1-pyrroline-2-carboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54573", "l": "a uridine in tRNA => a pseudouridine in tRNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21734", "l": "anthranilate + H(+) + L-glutamate + pyruvate => chorismate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64779", "l": "3-sulfanylpentan-1-ol-L-cysteine <=> 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9833635", "l": "p-PKR dimer localizes to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16538", "l": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O => (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236970", "l": "Proteasomal clevage of exogenous antigen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39505", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+) => (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15523", "l": "CoA + H(+) + N-tetradecanoylglycyl-[protein] => N-terminal glycyl-[protein] + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018503", "l": "ESR1:ESTG bind the EBAG9 5' region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25749", "l": "2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102880", "l": "isobazzanene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = isobazzanene + diphosphoric acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36123", "l": "gibberellin A20 + S-adenosyl-L-methionine = gibberellin A20 methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0030572", "l": "phosphatidyltransferase activity", "d": ["Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869694", "l": "oxPL binds CD14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27871", "l": "(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9853512", "l": "DLST transfers succinyl to CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60322", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9646468", "l": "mTORC1 binds RHEB:GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23128", "l": "4-hydroxybutanoate + ATP + CoA = 4-hydroxybutanoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.40", "l": "\"4-hydroxybutyrate--CoA ligase (AMP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76519", "l": "H2O + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] = (R)-lipoate + L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}, {"i": "EC:3.5.1.138", "l": "\"lipoamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395764", "l": "atREs binds to nascent CM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.190", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56204", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] = 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31352", "l": "lupan-3beta,20-diol => (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40970", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34859", "l": "3-oxocyclopentanecarbonitrile + 2 H2O = 3-oxocyclopentanecarboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58768", "l": "1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.31", "l": "\"NAD(+)--protein-arginine ADP-ribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0005035", "l": "death receptor activity", "d": ["Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72211", "l": "(+)-isoborneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835385", "l": "DUS2 binds PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28403", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45933", "l": "2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29574", "l": "H(+)(in) + L-idonate(in) <=> H(+)(out) + L-idonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23535", "l": "ATP + cholate + CoA <=> AMP + choloyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432428", "l": "Cytosolic CRY is degraded by the 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13444", "l": "H2O + L-cysteate <=> H(+) + NH4(+) + pyruvate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42805", "l": "5,6,7,8-tetrahydromethanopterin + A => 7,8-dihydromethanopterin + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62666", "l": "deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine => (2'R)-atrovenetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23240", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68484", "l": "(2R)-2-hydroperoxydodecanoate + H(+) = CO2 + H2O + undecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34171", "l": "L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O", "d": [], "t": []}, {"i": "EC:4.3.3.7", "l": "\"4-hydroxy-tetrahydrodipicolinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58164", "l": "(2E,6E)-farnesyl diphosphate + 2 H2O = 7-epi-ent-eudesmane-5,11-diol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.197", "l": "\"eudesmane-5,11-diol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62146", "l": "2 dGDP => dGMP + dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42132", "l": "isonocardicin C = nocardicin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004803", "l": "transposase activity", "d": ["Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43579", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686336", "l": "SARS-CoV-1 3a oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666008", "l": "SCAI binds SRF:MKL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4088134", "l": "PLK1 phosphorylates FOXM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22544", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50757", "l": "NADP(+) + reduced [flavodoxin] => 2 H(+) + NADPH + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56886", "l": "2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => adenosine(32) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.64", "l": "\"caspase-11\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.30", "l": "\"pycnoporopepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24006", "l": "(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] => butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75372", "l": "guanosine(in) => guanosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005458", "l": "GDP-mannose transmembrane transporter activity", "d": ["Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26216", "l": "9alpha-copalyl diphosphate + H2O <=> aphidicolan-16beta-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28987", "l": "H(+)(in) + N-acetylneuraminate(in) = H(+)(out) + N-acetylneuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14779", "l": "IMP + NH4(+) => AMP + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28842", "l": "H(+)(out) + Zn(2+)(in) <=> H(+)(in) + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18838", "l": "10-deacetyltaxuyunnanin C + acetyl-CoA => CoA + taxuyunnanin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-448958", "l": "Nuclear translocation of p38 MAPK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26238", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (2E,6E,10E)-geranylgeraniol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19346", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113643", "l": "Replication initiation regulation by Rb1/E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22165", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => a globoside Forssman (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30831", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55766", "l": "2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol => 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12042", "l": "3-(imidazol-5-yl)pyruvate + H(+) + NADPH => (S)-3-(imidazol-5-yl)lactate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641206", "l": "RSPOs bind LGRs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71834", "l": "chloride(out) + creatine(out) + 2 Na(+)(out) <=> chloride(in) + creatine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52577", "l": "hexanoyl-CoA + NAD(+) => (2E)-hexenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35650", "l": "ATP + GTP <=> 3',3'-cGAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171106", "l": "LDLR:LDL complex => LDLR + LDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19742", "l": "formyl-CoA + H2O => CoA + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.50", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78570", "l": "acetyl-CoA + docosanoyl-CoA <=> 3-oxotetracosanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940959", "l": "Neurolysin degrades neurotensin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72371", "l": "dehydroepiandrosterone 3-sulfate(out) + succinate(in) = dehydroepiandrosterone 3-sulfate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.138", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008396", "l": "oxysterol 7-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033711", "l": "4-phosphoerythronate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-phospho-D-erythronate + NAD+ = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34576", "l": "2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23645", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578777", "l": "DMPK phosphorylates PLN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13302", "l": "a 1,2-diacyl-sn-glycerol + a sterol => a 1-acyl-sn-glycerol + a sterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74568", "l": "L-glutamate(in) + N-acetyl-L-cysteine(out) => L-glutamate(out) + N-acetyl-L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36617", "l": "CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine => 2-hydroxyoctadecanoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18970", "l": "a long-chain fatty acid + H(+) + hnu => a long-chain alkane + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42327", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n) <=> 3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33265", "l": "(E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176956", "l": "Formation of GINS complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38560", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate => (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008609", "l": "alkylglycerone-phosphate synthase activity", "d": ["Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42975", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a cardiolipin + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.98.-", "l": "\"With other known acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944216", "l": "Association of procollagen type XV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14771", "l": "(S)-6-hydroxynicotine + AH2 => (S)-nicotine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0001530", "l": "lipopolysaccharide binding", "d": ["Binding to a lipopolysaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862300", "l": "LYZ binds bacterial peptidoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71740", "l": "2-oxoadipate(in) + 2-oxoglutarate(out) => 2-oxoadipate(out) + 2-oxoglutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67548", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209111", "l": "Translation of p14ARF mRNA is inhibited by miR-24 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75285", "l": "10-hydroxydecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => decanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.6", "l": "\"AMP deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102161", "l": "copal-8-ol diphosphate synthase activity", "d": ["Catalysis of the reaction: copal-8-ol diphosphate = 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42368", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.124", "l": "\"dihydromonacolin L hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52714", "l": "2-deoxy-D-ribose 5-phosphate + thymine => dTMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14981", "l": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850797", "l": "SPINK6 binds KLK13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23345", "l": "a purine D-ribonucleoside + H2O => a purine nucleobase + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77819", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-alanine + O2 = 2-dehydro-D-glucose + H2O2 + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.111153221370472", "identifiers": [{"i": "GO:0016796", "l": "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters."], "t": []}, {"i": "EC:3.1.15.-", "l": "\"Exonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75468", "l": "ethanolamine(out) + n H(+)(in) => ethanolamine(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25024", "l": "CTP + riboflavin <=> CDP + FMN + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368119", "l": "Expression of CLOCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35218", "l": "H2O + XDP <=> H(+) + phosphate + XMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9858590", "l": "DLST transfers glutaryl to CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683925", "l": "ULK1 is dephosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77839", "l": "(2S)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]pentanedioate + H(+) + H2O = 2-dehydro-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374919", "l": "Noradrenaline clearance from the synaptic cleft (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57057", "l": "D-apiofuranose + NAD(+) => D-apionolactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24685", "l": "5,10-methylenetetrahydromethanopterin + NADP(+) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11501", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O => 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57389", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] => (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66639", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (-)-alpha-acorenol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60690", "l": "(11R)-dihydroartemisinate + 2 H(+) + NADH => (11R)-dihydroartemisinic aldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55171", "l": "[TtuB sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [TtuB sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592436", "l": "Initial activation of proMMP9 by MMPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55178", "l": "2-hydroxybutanoyl-CoA + CO2 + succinate => 2-oxoglutarate + butanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19745", "l": "3,3',5-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine", "d": [], "t": []}, {"i": "EC:1.21.99.4", "l": "\"thyroxine 5'-deiodinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47069", "l": "4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65680", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0038100", "l": "nodal binding", "d": ["Binding to a nodal protein, a member of the transforming growth factor-beta superfamily."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111238", "l": "Formation of ADAR2  homodimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001085", "l": "arabinogalactan binding", "d": ["Binding to arabinogalactan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76368", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(out) => n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698930", "l": "HCMV C Nucleocapsid Translocation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9006850", "l": "IL21 receptor JAK phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218832", "l": "CDC42:GTP binds PAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015528", "l": "lactose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448673", "l": "Formation of caspase-1 p10/p20 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20883", "l": "10-hydroxydecanoate + NAD(+) <=> 10-oxodecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51057", "l": "A + androst-4-ene-3,17-dione => AH2 + androsta-1,4-diene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41025", "l": "1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31137", "l": "5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047111", "l": "formate dehydrogenase (cytochrome-c-553) activity", "d": ["Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9761344", "l": "USP18 binds IKBKG within IKK complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0048407", "l": "platelet-derived growth factor binding", "d": ["Binding to platelet-derived growth factor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73800", "l": "SAICAR => AICAR + Fumarate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53030", "l": "H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP => lithocholate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918229", "l": "Phosphorylation and release of IRF3/IRF7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63430", "l": "ADP + D-glucose 6-phosphate + H(+) => ATP + H2O + levoglucosan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839358", "l": "Endocytosis of TGFBR3:ARRB complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102322", "l": "2-propylphenol monooxygenase activity", "d": ["Catalysis of the reaction: 2-propylphenol + O2 + NADH + H+ = 3-propylcatechol + H2O + NAD."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66510", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102817", "l": "caffeoyl-CoA:3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) 3'-O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + caffeoyl-CoA = gentiodelphin + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13689", "l": "diphosphate + glycerol = glycerol 1-phosphate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.79", "l": "\"diphosphate--glycerol phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17140", "l": "prostaglandin H2 <=> thromboxane A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67982", "l": "7,8-dihydro-beta-carotene => beta-zeacarotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57809", "l": "1-chloro-3-nitrobenzene + NADH + O2 => 3-chlorocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72952", "l": "butanoate(out) + 2 Na(+)(out) => butanoate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38597", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.116", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28984", "l": "nitrite(in) => nitrite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63179", "l": "(2S)-ibuprofenoyl-CoA <=> (2R)-ibuprofenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39158", "l": "(3R)-hydroxyoctadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24865", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 = 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44436", "l": "a 1,2-diacylglycerol + a 1-acylglycerol = a triacylglycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58845", "l": "(6E)-8-hydroxygeranial + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381109", "l": "IRE1 binds IRE1 forming dimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71640", "l": "K(+)(in) + Na(+)(in) => K(+)(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9823910", "l": "Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3828025", "l": "DCN (decorin) degradation by MMP14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19769", "l": "phaseollidin hydrate = H2O + phaseollidin", "d": [], "t": []}, {"i": "EC:4.2.1.97", "l": "\"phaseollidin hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19798", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O => 1D-myo-inositol 1,4-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106256", "l": "hydroperoxy icosatetraenoate dehydratase activity", "d": ["A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30650", "l": "1D-myo-inositol 3-phosphate + CTP + H(+) <=> CDP-1L-myo-inositol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69142", "l": "Recruitment of Dna2 endonuclease (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17964", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> H2O + leukotriene A4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35974", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate <=> diphosphate + fumitremorgin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019163", "l": "pyridoxamine-phosphate transaminase activity", "d": ["Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59257", "l": "Fe(III)-enterobactin + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31682", "l": "O2 + prosolanapyrone II <=> H2O2 + prosolanapyrone III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624120", "l": "CEBPA binds CDK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9839072", "l": "HTRA2 degrades APP (Amyloid-beta precursor protein) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008031", "l": "eclosion hormone activity", "d": ["The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40930", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44420", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956676", "l": "YAP1 binds TP73 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8873850", "l": "STARD5 binds DCA, LCA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047644", "l": "alizarin 2-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: alizarin + UDP-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770141", "l": "Formation of the Spliceosomal C* complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371422", "l": "ATP hydrolysis by HSP70 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71593", "l": "2-oxoglutarate(in) + malonate(out) => 2-oxoglutarate(out) + malonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15462", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.884407581586458", "identifiers": [{"i": "GO:0008080", "l": "N-acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804379", "l": "PRMT5 binds TTC5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793949", "l": "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10731", "l": "GDP-6-deoxy-alpha-D-talose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983061", "l": "TSLP binds CRLF2:IL7R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29286", "l": "L-alanine(in) + Na(+)(in) <=> L-alanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71981", "l": "diphosphate + fusoxypene A => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50464", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH = 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66416", "l": "ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O = ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018532", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity", "d": ["Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36288", "l": "H(+) + NADPH + O2 + theobromine => 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18015", "l": "ethylamine + L-glutamate => H2O + N(5)-ethyl-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042497", "l": "triacyl lipopeptide binding", "d": ["Binding to a lipopeptide containing a nonprotein moiety consisting of three acyl groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74794", "l": "(R)-salsolinol(in) <=> (R)-salsolinol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53010", "l": "di-trans,poly-cis-polyprenyl diphosphate + n diphosphate => (2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22161", "l": "4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside => a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43293", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56411", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24370", "l": "L-proline + NH4(+) => L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11901", "l": "(2R,3S)-homoisocitrate + NAD(+) => 2-oxoadipate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9842833", "l": "SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17752", "l": "A + H2O + quinoline <=> AH2 + quinolin-2(1H)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43601", "l": "3-oxoeicosanoyl-[ACP] + H(+) + NADPH => 3R-hydroxyeicosanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2484882", "l": "Collagen type X degradation by MMP3, 13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14995", "l": "a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+) => acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67097", "l": "2-oxoglutarate + asnovolin A + 2 O2 => CO2 + fumigatonoid A + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-481007", "l": "Exocytosis of platelet alpha granule contents (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57132", "l": "L-ascorbate + O2 + tyramine = (R)-octopamine + H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030151", "l": "molybdenum ion binding", "d": ["Binding to a molybdenum ion (Mo)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27794", "l": "(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + 4 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.30", "l": "\"heptaprenyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29977", "l": "2'-deoxycytidine(out) + H(+)(out) => 2'-deoxycytidine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67832", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800120", "l": "POU5F1 (OCT4), SOX2, NANOG bind DPPA4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71165", "l": "H(+)(out) + L-alanine(in) + Na(+)(in) => H(+)(in) + L-alanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70573", "l": "D-glucose(in) + Na(+)(in) => D-glucose(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49859", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047927", "l": "gibberellin-44 dioxygenase activity", "d": ["Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380272", "l": "Plk1-mediated phosphorylation of Nlp (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140031", "l": "phosphorylation-dependent protein binding", "d": ["Binding to a protein upon phosphorylation of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203977", "l": "SAR1 Activation And Membrane Binding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32935", "l": "a cardiolipin + H2O = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247836", "l": "Retromer recycles WLS to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56521", "l": "Fe-coproporphyrin III + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10709", "l": "alpha-D-glucose 1-phosphate + GTP + H(+) => diphosphate + GDP-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205238", "l": "SHP2 interacts with p-KIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57020", "l": "apulose + ATP = ADP + apulose 4-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.233", "l": "\"apulose kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.12", "l": "\"DNA helicase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40575", "l": "glutaryl-CoA + H2O = CoA + glutarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62452", "l": "ATP + holo-[peptidyl-carrier protein] + L-glutamate = AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein]", "d": [], "t": []}, {"i": "EC:6.2.1.68", "l": "\"L-glutamate--[L-glutamyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018746", "l": "RHOQ binds effectors at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67887", "l": "3'-phosphoadenylyl sulfate + dopamine <=> adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40593", "l": "CoA + decanedioate + H(+) => decanedioyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508451", "l": "PTK2B is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672957", "l": "PP2A dephosphorylates KSR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63283", "l": "a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9909159", "l": "HK1 phosphorylates Mannose to Man6P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656259", "l": "Defective HEXA does not cleave the terminal GalNAc from DS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9846501", "l": "B3GNT5 transfers GlcNAc to LacCer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43669", "l": "ATP + hexacosanoyl-CoA + hydrogencarbonate => 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-381668", "l": "cAMP activates EPAC1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801762", "l": "REG3A oligomerize to form a pore complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39225", "l": "(2E)-octacosenoyl-CoA + H2O => (3R)-hydroxyoctacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63483", "l": "NADP(+) + prostaglandin F2alpha <=> 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.75", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016994", "l": "precorrin-6A reductase activity", "d": ["Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55268", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate = (R)-glycerate + alpha-D-glucose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.352", "l": "\"glucosylglycerate phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203611", "l": "N-myristoylation of eNOS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649733", "l": "mature p21 RAS binds GDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23923", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050211", "l": "procollagen galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050367", "l": "tyrosine-arginine ligase activity", "d": ["Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75853", "l": "all-trans-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67225", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74258", "l": "XDH oxidizes xanthine to form urate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052875", "l": "riboflavin reductase (NAD(P)H) activity", "d": ["Catalysis of the reaction: reduced riboflavin + NAD(P)+ = riboflavin + NAD(P)H + 2 H+. This reaction can utilize NADH and NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662608", "l": "MT2A binds cadmium (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36070", "l": "Co-precorrin-6B + S-adenosyl-L-methionine <=> Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179413", "l": "Activated PKC-alpha  activate MMP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69620", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35507", "l": "30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13738", "l": "an n-alkanal + NADP(+) => an alk-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9761027", "l": "ZEB2 binds SP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24710", "l": "2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose = L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose", "d": [], "t": []}, {"i": "EC:2.6.1.87", "l": "\"UDP-4-amino-4-deoxy-L-arabinose aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21217", "l": "ATP + D-ribose 5-phosphate => ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755765", "l": "C-ter TLR7 dimer binds SARS-CoV-2 GU-rich ssRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952996", "l": "E2F7 forms homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.176", "l": "\"cellulose 1,4-beta-cellobiosidase (reducing end)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54779", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine <=> [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27590", "l": "(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.44", "l": "\"pantoate--beta-alanine ligase (ADP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74778", "l": "kaempferide + S-adenosyl-L-methionine <=> 7,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050487", "l": "sulfoacetaldehyde acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl phosphate + H+ + sulfite = phosphate + sulfoacetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49795", "l": "eicosanoyl-CoA + glycine <=> CoA + H(+) + N-eicosanoylglycinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16629", "l": "(S)-malyl-CoA = acetyl-CoA + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018460", "l": "cyclohexanol dehydrogenase activity", "d": ["Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77987", "l": "9-hydroxy-octadecanoate + a triacylglycerol = 9-(acyloxy)-octadecanoate + a 1,3-diacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68243", "l": "L-methionine(in) + Na(+)(in) <=> L-methionine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033520", "l": "TYSND1 cleaves TYSND1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22815", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) <=> (6R)-5,10-methenyltetrahydrofolate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031875", "l": "type 4 proteinase activated receptor binding", "d": ["Binding to a type 4 proteinase activated receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69732", "l": "CoA + phenylacetyl-AMP => AMP + H(+) + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48314", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+) => benzoyl-CoA + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018848", "l": "pinocarveol isomerase activity", "d": ["Catalysis of the reaction: pinocarveol = carveol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16430", "l": "ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74229", "l": "L-threonine + tRNA(Ile) => H2O + L-threonyl-tRNA(Ile)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018644", "l": "toluene 2-monooxygenase activity", "d": ["Catalysis of the reaction: toluene + H+ + NADH + O2 = 2-hydroxytoluene + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67071", "l": "AH2 + chermesin D methyl ester <=> A + asnovolin J", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389350", "l": "Activation of Cdc42 by pVav1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019135", "l": "deoxyhypusine monooxygenase activity", "d": ["Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209815", "l": "Tyrosine is monoiodinated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36518", "l": "H(+) + malonyl-CoA + tetracosanoyl-CoA <=> 3-oxohexacosanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31666", "l": "2-oxoglutarate + UDP-N-acetylbacillosamine <=> L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70607", "l": "3'-phosphoadenylyl sulfate + 4-ethylphenol = 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14497", "l": "A + pyridoxine = AH2 + isopyridoxal", "d": [], "t": []}, {"i": "EC:1.1.99.9", "l": "\"pyridoxine 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77909", "l": "1-formylpyrrolizidine + 2 H2O2 + 2 NH4(+) => H2O + 2 O2 + sym-homospermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66681", "l": "ATP + coproporphyrinogen III(in) + H2O => ADP + coproporphyrinogen III(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610722", "l": "CK1 phosphorylates p-GLI3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050020", "l": "L-arabinonate dehydratase activity", "d": ["Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015228", "l": "coenzyme A transmembrane transporter activity", "d": ["Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844241", "l": "ADAMTS13 cleaves VWF variant multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15439", "l": "a long-chain fatty acyl-CoA + H(+) + NADPH => a long-chain fatty aldehyde + CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675790", "l": "MTORC1 dissociates from ULK complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51129", "l": "A + an aliphatic amine + H2O => AH2 + an aldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34141", "l": "CO2 + Delta(9)-tetrahydrocannabinol => Delta(9)-tetrahydrocannabinolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24141", "l": "guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71265", "l": "chloride(in) + L-proline(in) + 2 Na(+)(in) => chloride(out) + L-proline(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0022821", "l": "solute:potassium antiporter activity", "d": ["Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685542", "l": "Viral release (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42049", "l": "3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14326", "l": "7,8-dihydroxycoumarin + UDP-alpha-D-glucose => daphnin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17930", "l": "an N-acylsphing-4-enine + ATP => ADP + an N-acylsphing-4-enine 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71719", "l": "H(+)(out) + L-methionyl-L-phenylalanyl-L-methionine(out) = H(+)(in) + L-methionyl-L-phenylalanyl-L-methionine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30607", "l": "A + all-trans-phytofluene = AH2 + all-trans-zeta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31179", "l": "(3S)-3-hydroxydodecanoyl-CoA + NAD(+) = 3-oxododecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.219", "l": "\"dihydroflavanol 4-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452338", "l": "Expression of TDGF1 (CRIPTO) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68421", "l": "cis-(homo)3aconitate + H2O => (2R,3S)-iso(homo)3citrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191654", "l": "c-src associates with Cx43 in gap junctions (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11161", "l": "2-oxoglutarate + L-2,4-diaminobutanoate => L-aspartate 4-semialdehyde + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54136", "l": "cytidine(48) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090655", "l": "double-stranded/single-stranded junction telomeric DNA binding", "d": ["Binding to a junction formed at the point where double-stranded telomeric DNA becomes a single-stranded G-rich telomeric DNA 3' overhang."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.109", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25646", "l": "(2R,5R)-isomenthone + NADP(+) => (R)-pulegone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.32", "l": "\"codeine 3-O-demethylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73778", "l": "dimethylallyl diphosphate + preechinulin <=> diphosphate + tardioxopiperazine B", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813626", "l": "LEAP2 binds bacteria (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22509", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) => diphosphate + DNA(n+1)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20978", "l": "an aldehyde + H(+) + H2O2 + nitrite => a primary nitroalkane + H2O + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706336", "l": "Active FLT3 binds to SYK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48602", "l": "[protein-PII]-L-tyrosine + H(+) + UMP => [protein-PII]-uridylyl-L-tyrosine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798474", "l": "S100A8:S100A9 binds Zn2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18876", "l": "3-chloro-D-alanine + H2O <=> chloride + H(+) + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63173", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA => (25R)-3-oxocholest-4-en-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52526", "l": "20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52742", "l": "aminomethylphosphonate + glyoxylate + H(+) + H2O2 => glyphosate + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10375", "l": "CoA + NAD(+) + phenylglyoxylate <=> benzoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59426", "l": "benzaldehyde + H2O2 + NH4(+) => benzylamine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177922", "l": "EGFR dimerization (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.23", "l": "\"mucorpepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874079", "l": "PTK2 binds activated MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10613", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630053", "l": "NTHL1 D239Y does not cleave thymine glycol (Tg) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42839", "l": "acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH <=> 5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20668", "l": "1,5-anhydro-D-glucitol + NADP(+) <=> 1,5-anhydro-D-fructose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661217", "l": "MT1A binds zinc (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54761", "l": "ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide => 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74590", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-exo-beta-bergamotene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47516", "l": "3-oxochenodeoxycholate + H(+) + NADH = isochenodeoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14539", "l": "1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+) => 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20563", "l": "CO2 + glycolaldehyde => 3-hydroxypyruvate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791177", "l": "Expression of KLHDC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944454", "l": "mTORC1 phosphorylates MAF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12390", "l": "2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => formononetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29153", "l": "3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out) => 3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22807", "l": "(6S,9R)-vomifoliol + NAD(+) <=> (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67058", "l": "chermesin D methyl ester + S-adenosyl-L-homocysteine => chermesin D + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110311", "l": "POLZ extends translesion synthesis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623240", "l": "FOXO1 binds PPARGC1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68103", "l": "NAD(+) + xylitol <=> H(+) + L-xylulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793472", "l": "RIPK3 binds p-S9-PRKN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050073", "l": "macrolide 2'-kinase activity", "d": ["Catalysis of the reaction: ATP + oleandomycin = ADP + 2 H+ + oleandomycin 2'-O-phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36950", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68670", "l": "16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688459", "l": "RIPK3 binds HSP90:CDC37 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63673", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH => H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418856", "l": "Activation of Rac1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67533", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029456", "l": "RAC1 and CDC42 activate PAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102628", "l": "costunolide 3beta-hydroxylase activity", "d": ["Catalysis of the reaction: costunolide + NADPH + O2 + H+ = 3beta-hydroxycostunolide + NADP + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41258", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130731", "l": "Formation of COPII vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21235", "l": "L-histidine <=> NH4(+) + trans-urocanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71086", "l": "estrone 3-sulfate(out) + 2 Na(+)(out) <=> estrone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22277", "l": "2-oxoaldehyde + H2O + NAD(+) => a 2-oxocarboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033797", "l": "selenate reductase activity", "d": ["Catalysis of the reaction: 2 e(-) + 2 H+ + selenate = H2O + selenite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34274", "l": "2-nitroimidazole + H2O <=> 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46259", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22954", "l": "(2E)-octenedioyl-CoA + H2O2 => O2 + octanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605717", "l": "GM2A binds and mobilizes ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977626", "l": "C4b-binding protein binds C4b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34680", "l": "ATP + methylphosphonate => adenine + alpha-D-ribose 1-methylphosphonate 5-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48277", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75537", "l": "(R)-N-acetyl-S-methyl-L-cysteine sulfoxide + FMN + H(+) + H2O => FMNH2 + N-acetyl-S-methyl-L-cysteine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10976", "l": "H(+) + NADH + O2 + quinolin-2-ol = 5,6-dihydroquinoline-2,5,6-triol + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.16", "l": "\"2-hydroxyquinoline 5,6-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31381", "l": "1H-pyrrole + hydrogencarbonate => H2O + pyrrole-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26408", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) <=> H(+) + 4 H2O + phosphate + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30469", "l": "(+)-endo-beta-bergamotene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875623", "l": "SLC25A18,22 import L-Glu, H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16667", "l": "(5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate => (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.18", "l": "\"cytosol non-specific dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676257", "l": "Formation of the SET1A complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350901", "l": "Iodide is organified (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4167511", "l": "HLCS biotinylates ACACB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33978", "l": "DIMBOA beta-D-glucoside + H2O <=> D-glucose + DIMBOA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76931", "l": "3-aminobutan-2-ol + H2O + NADP(+) = acetoin + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53932", "l": "O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66485", "l": "16alpha-hydroxygypsogenate + UDP-alpha-D-glucose => 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72697", "l": "Start codon recognition (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659820", "l": "RB1 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61198", "l": "CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9823904", "l": "TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9855212", "l": "SDHA binds to SDHB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52815", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9845516", "l": "B3GALT4 transfers Gal to gangliosides (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65468", "l": "1-propanol + acetyl-CoA = CoA + propyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12959", "l": "acetate + an aliphatic alcohol + H(+) => an acetyl ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75501", "l": "cholate(in) + n H(+)(in) => cholate(out) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57340", "l": "3-hydroxy-L-kynurenine + S-adenosyl-L-methionine = 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70726", "l": "sitosterol(out) <=> sitosterol(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606564", "l": "GALC hydrolyzes GalCer (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654425", "l": "Activated FGFR4 binds SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2509827", "l": "ITPA hydrolyses ITP to IMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23537", "l": "alpha-D-glucose 1-phosphate => alpha-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24316", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (+)-copalyl diphosphate", "d": [], "t": []}, {"i": "EC:5.5.1.12", "l": "\"copalyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19806", "l": "a purine D-ribonucleoside + phosphate => a purine nucleobase + alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10013", "l": "(R)-6-hydroxynicotine + H2O + O2 => 6-hydroxypseudooxynicotine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34897", "l": "ADP + H(+) + phosphate + selenite(in) => ATP + H2O + selenite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51925", "l": "AH2 + menaquinone-9 => A + beta-dihydromenaquinone-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76023", "l": "18-hydroxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-oxocortisol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44135", "l": "2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70967", "l": "IDH3 complex decarboxylates isocitrate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57104", "l": "[(1->4)-alpha-D-galacturonosyl](n) = 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)", "d": [], "t": []}, {"i": "EC:4.2.2.9", "l": "\"pectate disaccharide-lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012073", "l": "Autocatalytic phosphorylation of FGFR3c P250R mutant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38797", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44558", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-hexaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15561", "l": "S-adenosyl-L-methionine + sterigmatocystin = 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55027", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13089", "l": "6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) = 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite", "d": [], "t": []}, {"i": "EC:1.7.2.2", "l": "\"nitrite reductase (cytochrome; ammonia-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687520", "l": "MetAsp transforms to L-Asp,isoAsp (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40789", "l": "CoA + H(+) + tetracosanoate => H2O + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39866", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665304", "l": "ERBB2 T862A does not bind sapitinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029988", "l": "Dimerization of overexpressed FGFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67207", "l": "H2O + N-acetyltryptamine <=> acetate + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.10", "l": "\"2-haloacid dehalogenase (configuration-inverting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54121", "l": "coelenterazine h + O2 => coelenterazine h dioxetanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114254", "l": "CYCS binds to APAF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9770119", "l": "Formation of the Spliceosomal E complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114352", "l": "Sequestration of tBID by BCL-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432164", "l": "Ca2+ influx into the post-synaptic cell (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0018812", "l": "3-hydroxyacyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63236", "l": "ATP + streptomycin = 6-O-adenylylstreptomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050349", "l": "triacetate-lactonase activity", "d": ["Catalysis of the reaction: H2O + triacetate lactone = triacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50538", "l": "H2O + prostaglandin A2 => prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028583", "l": "Phosphorylation of YAP by LATS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58108", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9853368", "l": "FIRRM binds FIGNL1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75386", "l": "bromide(in) <=> bromide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705926", "l": "AR binds AR agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48049", "l": "a ganglioside GM1 (d18:1(4E)) + H2O => a ganglioside GM2 (d18:1(4E)) + D-galactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043887", "l": "melibiose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47196", "l": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876472", "l": "NPC2 binds CHOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757445", "l": "ST translocates from ER lumen to cytosol of GI cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.-", "l": "\"Peroxidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67184", "l": "(glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine = (glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45231", "l": "a (3E)-enoyl-CoA <=> a 4-saturated (2E)-enoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25835", "l": "1D-chiro-inositol + NAD(+) <=> H(+) + NADH + scyllo-inosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299297", "l": "Activation of THIK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19081", "l": "1-haloalkane + H2O = a halide anion + a primary alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60387", "l": "enterobactin + H2O <=> N-(2,3-dihydroxybenzoyl)-L-serine trimer", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836606", "l": "SPHK1 binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75872", "l": "Conversion of malonyl-CoA and acetyl-CoA to palmitate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36827", "l": "dioscin + 3 H2O = D-glucose + diosgenin + 2 L-rhamnopyranose", "d": [], "t": []}, {"i": "EC:3.2.1.189", "l": "\"dioscin glycosidase (diosgenin-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3878123", "l": "Initiation of SAHF formation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28928", "l": "3,4,5-trihydroxybenzoate + O2 => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.n1", "l": "\"cytokinin riboside 5'-monophosphate phosphoribohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71649", "l": "a medium-chain (2E)-enoyl-CoA + H2O => a medium-chain (3S)-3-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043125", "l": "ErbB-3 class receptor binding", "d": ["Binding to the protein-tyrosine kinase receptor ErbB-3/HER3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32845", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432295", "l": "GPVI binds Fyn and Lyn (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57931", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine <=> ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004135", "l": "amylo-alpha-1,6-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52318", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836702", "l": "PKR inhibitors bind PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164840", "l": "ADP and Pi bind to ATPase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25260", "l": "N-acetyl-D-glucosamine 6-phosphate <=> N-acetyl-D-mannosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44930", "l": "(R)-trihomocitrate + CoA + H(+) => 2-oxoheptanedioate + acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190256", "l": "FGFR1c binds to FGF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26383", "l": "H(+) + NADPH + succinate semialdehyde => 4-hydroxybutanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.174", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24777", "l": "H2O + pheophorbide a => C-13(2)-carboxypyropheophorbide a + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769383", "l": "CBY1 binds beta-catenin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68680", "l": "3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate) = 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32914", "l": "sn-glycerol 3-phosphocholine(out) <=> sn-glycerol 3-phosphocholine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106405", "l": "isoprenoid diphosphate phosphatase activity", "d": ["Catalysis of the dephosphorylation of isoprenoid diphosphates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426489", "l": "RISC binds inexactly matching target RNAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685319", "l": "CX3 complex formation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64792", "l": "L-lysine + NADP(+) = 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018794", "l": "2-hydroxyisobutyrate decarboxylase activity", "d": ["Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42977", "l": "L-tryptophan => 2-aminoprop-2-enoate + indole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903794", "l": "cortisol binding", "d": ["Binding to cortisol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0032554", "l": "purine deoxyribonucleotide binding", "d": ["Binding to a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205238", "l": "SHP2 interacts with p-KIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851096", "l": "NPM1-ALK- and JNK-dependent JUN phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72033", "l": "(E)-sinapaldehyde + H2O2 => (E)-sinapyl alcohol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41536", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.303", "l": "\"2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69604", "l": "UTP => 3',5'-cyclic UMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046965", "l": "nuclear retinoid X receptor binding", "d": ["Binding to a nuclear retinoid X receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156930", "l": "GTP-binding activates eEF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57986", "l": "(20S)-ginsenoside Rd + H(+) + UDP => (20S)-ginsenoside Rg3 + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69157", "l": "spermine dialdehyde => acrolein + N-(4-aminobutyl)-3-aminopropanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39810", "l": "octadecanoate(in) <=> octadecanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798257", "l": "PTPRS binds NTRK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46264", "l": "an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62270", "l": "3-methyl-2-oxobutanoate + H(+) + NADPH => (R)-2-hydroxy-3-methylbutyrate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46137", "l": "aminopyrrolnitrin + H(+) + NADPH + 2 O2 => 2 H2O + NADP(+) + pyrrolnitrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62337", "l": "AMP + ATP => adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.039770584279694", "identifiers": [{"i": "GO:0008092", "l": "cytoskeletal protein binding", "d": ["Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701147", "l": "TRPV1 binds TRPV1 blockers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60921", "l": "2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 => a cytidine in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853325", "l": "Plasma membrane FGFR1 fusions autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65138", "l": "1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14669", "l": "D-glyceraldehyde 3-phosphate + H2O + NADP(+) = (2R)-3-phosphoglycerate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21525", "l": "3-methyl-2-oxobutanoate + acetyl-CoA + H2O => (2S)-2-isopropylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39981", "l": "H(+) + N-methylpavine + S-adenosyl-L-homocysteine => (+-)-pavine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27278", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40005", "l": "(Z)-biformene + diphosphate => ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70501", "l": "PC carboxylates PYR to OA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936007", "l": "CLDN5 (Claudin-5) gene expression is stimulated by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71908", "l": "GDP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12574", "l": "adenosylcob(III)inamide + ADP + H(+) + phosphate => (R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45893", "l": "an N-acylsphing-4-enine + CDP-ethanolamine => an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69454", "l": "3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+) => 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390593", "l": "ATP Hydrolysis By Myosin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047742", "l": "chenodeoxycholoyltaurine hydrolase activity", "d": ["Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50547", "l": "prostaglandin C2 <=> prostaglandin B2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047431", "l": "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity", "d": ["Catalysis of the reaction: 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H+ = 5-hydroxy-6-methylpyridine-3-carboxylate + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71806", "l": "acetate(out) + H(+)(out) <=> acetate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191299", "l": "Squalene is oxidized to its epoxide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73670", "l": "(E,E)-piperoyl-CoA + 2-methylpropan-1-amine <=> (E,E)-piperlonguminine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51993", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9702849", "l": "CALCR binds gepants (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909732", "l": "Phosphorylation of STAT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851908", "l": "Activated MET binds GAB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.25", "l": "\"cucumisin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928620", "l": "PAK1 autophosphorylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.74", "l": "\"glycosaminoglycan galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65223", "l": "(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) <=> catechol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25824", "l": "H2O + O2 + spermine = H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60304", "l": "N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45656", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15924", "l": "2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol <=> a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59024", "l": "H2O + trihexadecanoylglycerol = dihexadecanoylglycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114544", "l": "p115-RhoGEF activation of RHOA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73258", "l": "(2S)-sakuranetin + S-adenosyl-L-methionine <=> (2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67143", "l": "L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 <=> H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611277", "l": "P2RY12 binds P2RY12 antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53750", "l": "a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2172678", "l": "PHF8 demethylates histone H4K20me1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158313", "l": "factor XII -> factor XIIa (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72763", "l": "anthocyanin A10 + malonyl-CoA = anthocyanin A11 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68173", "l": "2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2 => CO2 + H2O + isodomoate A + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26119", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.17.7.1", "l": "\"(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681694", "l": "TNC binds Syndecan-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60357", "l": "H2O + N-octanoylanthranilate => anthranilate + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20736", "l": "acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.29", "l": "\"glycine C-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018768", "l": "RHOU auto-activates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668904", "l": "Formation of the CTF18 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29197", "l": "a menaquinol + orotate => (S)-dihydroorotate + a menaquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374896", "l": "Uptake of Noradrenaline (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021596", "l": "Membrane estrogen receptors bind SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030367", "l": "interleukin-17 receptor binding", "d": ["Binding to an interleukin-17 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39700", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA => (2E,13Z)-eicosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691174", "l": "RAC1 binds effectors at the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983152", "l": "Transfer of ubiquitin from E1 to E2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12344", "l": "(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.70", "l": "\"glutamyl-tRNA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56797", "l": "ATP + cob(I)alamin-[corrinoid adenosyltransferase] => adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204863", "l": "Interaction of Tie2 with Ang2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57128", "l": "H2O + 2 oxidized [azurin] + tyramine = (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706298", "l": "Active FLT3 binds to CSK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710959", "l": "p-STAT1 dimer binds KPNA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14633", "l": "ATP + H2O + Na(+)(in) = ADP + H(+) + Na(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034957", "l": "3-nitrophenol nitroreductase activity", "d": ["Catalysis of the reaction: 3-nitrophenol + 2 NADH + 2 H+ = 3-hydroxyaminophenol + 2 NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416562", "l": "p190RhoGAP binds Plexin-B1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43677", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019141", "l": "2-dehydropantolactone reductase (B-specific) activity", "d": ["Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044378", "l": "non-sequence-specific DNA binding, bending", "d": ["The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755359", "l": "SARS-CoV-2 8:class I MHC binds BECN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416698", "l": "SEMA5A binds to PLXNB3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46190", "l": "a carboxylate + NH4(+) => an aliphatic nitrile + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73496", "l": "an 8-hydroxyflavone + S-adenosyl-L-methionine => an 8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693609", "l": "ATM phosphorylates TP53 at S15 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3239014", "l": "MAPKAPK5 phosphorylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67380", "l": "H2O + L-alanyl-L-cysteine = L-alanine + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73464", "l": "carcinine + H2O => beta-alanine + histamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0008477", "l": "purine nucleosidase activity", "d": ["Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9640195", "l": "RRAGA,B hydrolyzes GTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788623", "l": "p-Y-STATs translocate to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32188", "l": "cholest-5-en-3-one => cholest-4-en-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769143", "l": "NPAS4 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179417", "l": "Multiubiquitination of Nek2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13599", "l": "agmatine + urea => 1,4-diguanidinobutane + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72340", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+) => catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51606", "l": "4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14530", "l": "ADP + D-ribose 5-phosphate + H(+) => ADP-D-ribose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12189", "l": "2-oxoglutarate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] => CO2 + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786190", "l": "CMBL hydrolyses OM to OLMS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65762", "l": "a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675198", "l": "Activated MAPKs phosphorylate BRAF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53229", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625416", "l": "Anterograde IFT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851436", "l": "CFHR dimers bind C3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54185", "l": "an N-acyl-aromatic L-alpha-amino acid + H2O => a carboxylate + an aromatic L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194793", "l": "botC LC cleaves target cell SNAP25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "64.962680676965917", "identifiers": [{"i": "GO:0008509", "l": "monoatomic anion transmembrane transporter activity", "d": ["Enables the transfer of a negatively charged ion from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-166214", "l": "FA anion flip-flops to the opposite surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199112", "l": "CRTAM binds to NECL2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10968", "l": "a carboxylate + CoA + GTP = an acyl-CoA + GDP + phosphate", "d": [], "t": []}, {"i": "EC:6.2.1.10", "l": "\"acid--CoA ligase (GDP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.123", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213246", "l": "Disassociation of CLIP from MHC II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428750", "l": "Gq activation by TP receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56421", "l": "apo-[D-alanyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204465", "l": "Basigin interacts with CD43 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31252", "l": "(S)-3-hydroxyisobutanoyl-CoA + H2O => (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47944", "l": "(2E)-geranyl diphosphate + H2O = (2E)-geranyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11472", "l": "an N-methyl-L-amino acid + H2O + O2 = an L-alpha-amino acid + formaldehyde + H2O2", "d": [], "t": []}, {"i": "EC:1.5.3.2", "l": "\"N-methyl-L-amino-acid oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008742", "l": "L-ribulose-phosphate 4-epimerase activity", "d": ["Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9854463", "l": "SIRT3 deacetylates AcK-IDH2 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23470", "l": "2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+) => 2-aminobenzenesulfonate + 2 H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28429", "l": "D-allulose 6-phosphate <=> keto-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69009", "l": "2 H(+) + L-aspartate + 3 NADPH + 3 O2 => 2-nitrobutanedioate + 4 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.5.2", "l": "\"proline dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030746", "l": "isoflavone 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20183", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP => alpha-D-mannose derivative + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30533", "l": "biotin + H2O + NAD(+) => biotinate sulfoxide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17147", "l": "2'-hydroxydaidzein + 2 H(+) + NADPH => 2'-hydroxy-2,3-dihydrodaidzein + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50697", "l": "calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062206", "l": "manoyl oxide synthase activity", "d": ["Catalysis of the reaction: 8-hydroxycopalyl diphosphate = (13R)-manoyl oxide + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62419", "l": "(E)-4-coumaroyl-CoA + H2O <=> 4-hydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70378", "l": "3-oxosphinganine + dodecanoyl-CoA <=> CoA + H(+) + N-dodecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68320", "l": "1D-myo-inositol 2,4,5-triphosphate + H2O = 1D-myo-inositol 2,5-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39165", "l": "(3R)-hydroxyhexadecanoyl-CoA + NADP(+) => 3-oxohexadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047392", "l": "CMP-N-acylneuraminate phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660662", "l": "ASC binds Caspase-8 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15234", "l": "Fe(III)-[cytochrome c] + H2O + nitric oxide => Fe(II)-[cytochrome c] + 2 H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73602", "l": "CDP(in) + CTP(out) <=> CDP(out) + CTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73526", "l": "TTP(out) + UTP(in) <=> TTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39793", "l": "20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64735", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26277", "l": "Co-precorrin-4 + S-adenosyl-L-methionine = Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.271", "l": "\"cobalt-precorrin-4 methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38900", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140987", "l": "ATP:phosphate antiporter activity", "d": ["Enables the transfer of ATP from one side of a membrane to the other according to the reaction: ATP(out) + phosphate(in) = ATP(in) + phosphate(out)."], "t": []}, {"i": "RHEA:65840", "l": "ATP(out) + Mg(2+)(out) + phosphate(in) = ATP(in) + Mg(2+)(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29244", "l": "H(+) + menaquinone-8 + NADH => menaquinol-8 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30173", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP] => hexadecanoyl-[ACP] + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9861640", "l": "CTLH E3 ligase ubiquitinates PKM-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950364", "l": "IL23R in IL23:IL23 receptor complex is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032767", "l": "copper-dependent protein binding", "d": ["Binding to a protein or protein complex, in the presence of copper."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50597", "l": "acetyl-CoA + N-terminal L-seryl-[histone H4] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.4", "l": "\"alliin lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975040", "l": "KRAB-ZNF / KAP Interaction (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047384", "l": "[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity", "d": ["Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49016", "l": "aurachin C epoxide = 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005500", "l": "juvenile hormone binding", "d": ["Binding to a juvenile hormone, a sesquiterpenoid derivative that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786421", "l": "CHIA hydrolyses chitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853444", "l": "AURKA phosphorylates PHLDA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71987", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + fusoxypene C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36160", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23109", "l": "D-arabinono-1,4-lactone + H2O => D-arabinonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424484", "l": "Phosphorylation of BTK by p-SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23771", "l": "a fatty acyl-CoA + sphing-4-enine <=> an N-acylsphing-4-enine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663426", "l": "sCD163 binds MYH9 in T-cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54485", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine => 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49327", "l": "(5R,6S)-5,6-epoxi-capsanthin <=> all-trans-capsorubin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36898", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71622", "l": "(S)-malate(in) + 2 thiosulfate(out) <=> (S)-malate(out) + 2 thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77129", "l": "1D-myo-inositol 2,3-bisphosphate + phosphate => 1D-myo-inositol 1,2,3-trisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875568", "l": "RAPGEF1 activates RAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3221982", "l": "BANP binds TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33961", "l": "6'''-deamino-6'''-oxoneomycin C + L-glutamate => 2-oxoglutarate + neomycin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873927", "l": "Release of STAT1 dimer from active receptor unit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46078", "l": "eicosanoyl-CoA + NAD(+) => (2E)-eicosenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17501", "l": "H2O + polyneuridine aldehyde = 16-epivellosimine + CO2 + methanol", "d": [], "t": []}, {"i": "EC:3.1.1.78", "l": "\"polyneuridine-aldehyde esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42515", "l": "5-acetamidopentanoate + H2O <=> 5-aminopentanoate + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42879", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29214", "l": "H(+)(out) + inosine(in) <=> H(+)(in) + inosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33318", "l": "a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19158", "l": "D-xylonate => 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29046", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH <=> (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59151", "l": "ATP + CoA + marinolate C <=> AMP + diphosphate + marinoloyl-CoA C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193656", "l": "p75NTR interacts with RIP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35106", "l": "fusidate(in) <=> fusidate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29646", "l": "D-maltoheptaose + H2O <=> alpha-D-glucose + D-maltohexaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002056", "l": "cytosine binding", "d": ["Binding to cytosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10975", "l": "a D-hexose + H(+) + phosphoramidate <=> alpha-D-hexose 1-phosphate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169192", "l": "PTP1B dephosphorylates GHR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42546", "l": "pseudouridine(32) in tRNA => uridine(32) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032781", "l": "WWTR1 (TAZ) binds TEAD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60280", "l": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.367", "l": "\"[histone H3]-lysine(9) N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.19", "l": "\"C-19 steroid 1alpha-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31438", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46702", "l": "(R)-lipoyl-GMP + diphosphate => (R)-lipoate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24007", "l": "butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77853", "l": "2-dehydro-D-glucose + L-tyrosine => (2S)-3-(4-hydroxyphenyl)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018713", "l": "3-ketopimelyl-CoA thiolase activity", "d": ["Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42220", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141125", "l": "tRNA-queuosine(34) galactosyltransferase activity", "d": ["Catalysis of the reaction: queuosine34 in tRNA + UDP-alpha-D-galactose = H+ + O-5''-beta-D-galactosylqueuosine34 in tRNATyr + UDP. Substrates include tRNA(Tyr) and tRNA(Asp)."], "t": []}, {"i": "RHEA:78231", "l": "queuosine(34) in tRNA(Tyr) + UDP-alpha-D-galactose = H(+) + O-5''-beta-D-galactosylqueuosine(34) in tRNA(Tyr) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56609", "l": "5,10-methylenetetrahydrosulfopterin + glycine + H2O => L-serine + tetrahydrosulfopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047553", "l": "2-oxoglutarate synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754964", "l": "ADA deamidates RBV (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24366", "l": "2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694367", "l": "Glycosylated M localizes to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018785", "l": "haloacetate dehalogenase activity", "d": ["Catalysis of the reaction: haloacetate + H2O = glycolate + halide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036203", "l": "taxoid 14-beta-hydroxylase activity", "d": ["Catalysis of the reaction: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56568", "l": "a globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine = a globoside IV3GalNAc-Gb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35778", "l": "L-glutamine + UDP-3-oxo-alpha-D-glucose <=> 2-oxoglutaramate + UDP-alpha-D-kanosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855160", "l": "I(1,3,4,5,6)P5 transports from the ER lumen to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070411", "l": "I-SMAD binding", "d": ["Binding to an inhibitory SMAD signaling protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37092", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46869", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) => a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54845", "l": "H(+) + hexan-3-one + NADPH + O2 => ethyl butanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134954", "l": "DHX9 binds DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658438", "l": "SPRED dimer binds NF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354066", "l": "Translocation of PTK2 to Focal complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448480", "l": "IL22 binds IL22RA1:JAK1 receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58835", "l": "24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22154", "l": "a ubiquinol + D-glucono-1,5-lactone => a ubiquinone + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76194", "l": "carnosine(out) + 2 H(+)(out) <=> carnosine(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392834", "l": "Activation of EPACs by cAMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62059", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48135", "l": "(2E,6E)-farnesyl phosphate + H2O <=> (2E,6E)-farnesol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0005368", "l": "taurine transmembrane transporter activity", "d": ["Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24868", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2 <=> 4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36403", "l": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49340", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin = 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39644", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH => (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45850", "l": "3-oxododecanoyl-CoA + H(+) + NADPH => (3R)-3-hydroxydodecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33980", "l": "DIBOA beta-D-glucoside + H2O => D-glucose + DIBOA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27586", "l": "L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.99", "l": "\"L-tryptophan--pyruvate aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73190", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate <=> (2R,3S,11R)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0042922", "l": "neuromedin U receptor binding", "d": ["Binding to one or more specific sites on a neuromedin U receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13431", "l": "4-CDP-2-C-methyl-D-erythritol + diphosphate => 2-C-methyl-D-erythritol 4-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199093", "l": "CXADR binds to AMICA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32772", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate => 2,6-dioxo-6-phenylhexa-3-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-421831", "l": "trans-Golgi Network Coat Assembly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950504", "l": "IL27 binds CRLF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72793", "l": "(4E,15E)-bilirubin IXalpha C8-beta-D-glucuronoside(in) => (4E,15E)-bilirubin IXalpha C8-beta-D-glucuronoside(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34446", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose <=> CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15741", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) = 2,5-dichlorohydroquinone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58123", "l": "ATP + L-seryl-[protein] <=> 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49454", "l": "6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol => a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12865", "l": "1-methyladenosine + H2O = 1-methyladenine + D-ribose", "d": [], "t": []}, {"i": "EC:3.2.2.13", "l": "\"1-methyladenosine nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37916", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48237", "l": "2 2-acetylphloroglucinol => 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54303", "l": "n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate <=> n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0051019", "l": "mitogen-activated protein kinase binding", "d": ["Binding to a mitogen-activated protein kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69939", "l": "6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54342", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202534", "l": "Ubiquitination of NEMO by TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49428", "l": "CTP + phosphonoformate = CMP-5'-phosphonoformate + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.93", "l": "\"phosphonoformate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202947", "l": "Caspase mediated cleavage of APC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174224", "l": "Dissociation of Cdc20 from APC/C complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814555", "l": "Integrator complex processes the 3' end of snRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72256", "l": "dopamine + S-adenosyl-L-methionine => 3-methoxytyramine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013009", "l": "RHOA binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20850", "l": "acetyl phosphate + CO2 + H2O2 => H(+) + O2 + phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31856", "l": "(S)-2,3-epoxysqualene => achilleol B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43383", "l": "H2O + N(omega)-phospho-L-arginyl-[protein] <=> L-arginyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13734", "l": "an n-alkanal + NAD(+) => an alk-2-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24132", "l": "UDP-alpha-D-galactose = UDP-alpha-D-galactofuranose", "d": [], "t": []}, {"i": "EC:5.4.99.9", "l": "\"UDP-galactopyranose mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20529", "l": "2-cis-(+)-abscisic aldehyde + H2O + O2 = 2-cis-(+)-abscisate + H(+) + H2O2", "d": [], "t": []}, {"i": "EC:1.2.3.14", "l": "\"abscisic-aldehyde oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.1", "l": "\"alcohol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16812", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate <=> pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450325", "l": "c-FOS activation by phospho ERK1/2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67339", "l": "kaempferol 3-O-beta-D-glucoside + malonyl-CoA <=> CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015504", "l": "cytosine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9854368", "l": "ROS,RNS oxidize ACO2:4Fe-4S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18451", "l": "AH2 + arsenate + H(+) => A + arsenite + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56318", "l": "3-acetylamino-4-hydroxybenzoate + CoA => 3-amino-4-hydroxybenzoate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001070", "l": "starch binding", "d": ["Binding to starch."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418852", "l": "Caspase cleavage of UNC5B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209960", "l": "Diiodinated tyrosine can be deiodinated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77196", "l": "(3Z)-decenoyl-CoA => (2E)-decenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786155", "l": "POLN binds ICL-DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660757", "l": "Ub-SNCA dissociates from the conjugating enzyme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11054", "l": "4-aminophenol + CO2 + H2O + NAD(+) => 4-aminobenzoate + 2 H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54944", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.4.1.-", "l": "\"Forming carbon-carbon bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72702", "l": "acrylate + H(+) + NADH <=> NAD(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27346", "l": "FMNH2 + O2 => 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111916", "l": "Dimerization of p-S133-CREB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41653", "l": "aclacinomycin S + dTDP-2-deoxy-beta-L-fucose => 2-deoxy-alpha-L-fucosylaclacinomycin S + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11105", "l": "N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine => H(+) + hercynine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11261", "l": "H(+) + NADPH + O2 => H2O2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55081", "l": "ADP-alpha-D-glucose + D-fructose => ADP + H(+) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77495", "l": "acetophenone + hydrogen cyanide = (2S)-2-hydroxy-2-phenylpropanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621073", "l": "Immediate Early (IE) Gene Expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9760402", "l": "ILF3 binds HOXC8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32999", "l": "(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.114", "l": "\"amorpha-4,11-diene 12 monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30606", "l": "15-cis-phytoene + A <=> AH2 + all-trans-phytofluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37528", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56037", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41698", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate => 1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75255", "l": "mangiferin + O2 = 3'-dehydromangiferin + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374173", "l": "AGT(34-41) binds to AGTR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59889", "l": "4-chloro-L-lysine + AH2 + O2 => A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20188", "l": "a CMP-N-acyl-beta-neuraminate + H2O <=> an N-acylneuraminate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53352", "l": "5,6-dihydrouridine(20b) in tRNA + NAD(+) = H(+) + NADH + uridine(20b) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62933", "l": "H2O + N(4)-acetylcytidine => acetate + cytidine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17860", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17311", "l": "a phenol + acetate + H(+) => a phenyl acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17724", "l": "a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35035", "l": "4-aminobutanoate(in) = 4-aminobutanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140474", "l": "mitochondrion-endoplasmic reticulum membrane tether activity", "d": ["The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110440", "l": "Autophosphorylation of DINR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37582", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602473", "l": "Autocatalytic activation of MMP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75562", "l": "erinacol + O2 + reduced [NADPH--hemoprotein reductase] <=> cyathadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54062", "l": "(2Z,6E)-hedycaryol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23496", "l": "5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate", "d": [], "t": []}, {"i": "EC:2.8.3.14", "l": "\"5-hydroxypentanoate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60100", "l": "cyanidin + UDP-alpha-D-glucose = cyanidin 3-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44230", "l": "9-decenoyl-CoA + AMP + diphosphate => 9-decenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044585", "l": "cellobiose binding", "d": ["Binding to cellobiose, a disaccharide that represents the basic repeating unit of cellulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17524", "l": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) <=> ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796053", "l": "PRKCI phosphorylates NFE2L2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0005251", "l": "delayed rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395364", "l": "LTBP4 binds TGF-Beta-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39419", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35057", "l": "(2E,4E)-2,5-dichloromuconate + H(+) => 3,6-dichlorocatechol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33942", "l": "H(+) + L-arginine + NADH + O2 <=> H2O + N(omega)-hydroxy-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443439", "l": "c-Src binds Raf1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30088", "l": "(S)-2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617408", "l": "GLI3R binds the GLI1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12021", "l": "a monocarboxylic acid amide + H2O => a monocarboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34633", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77761", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + a triacylglycerol => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9842835", "l": "KRAB-ZFP binds retroelement DNA in chromatin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12526", "l": "Delta(1)-piperideine-2-carboxylate + H(+) + NADPH => L-pipecolate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55994", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11051", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid <=> 1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17977", "l": "a long-chain primary fatty alcohol + H2O + 2 NAD(+) = a long-chain fatty acid + 3 H(+) + 2 NADH", "d": [], "t": []}, {"i": "EC:1.1.1.192", "l": "\"long-chain-alcohol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56523", "l": "Fe-coproporphyrin III + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050578", "l": "(R)-2-hydroxyacid dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75114", "l": "32-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29931", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP = ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201521", "l": "ALK autophosphorylation  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16025", "l": "an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA = an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.171", "l": "\"anthocyanin 6''-O-malonyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404142", "l": "atROL binds RBP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36436", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(in) => a 1,2-diacyl-sn-glycero-3-phosphate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663258", "l": "NR1D1 (REV-ERBA) binds heme, the PPARGC1A gene, and recruits corepressors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43264", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-419644", "l": "Transphosphorylation of pLIMK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.62", "l": "\"beta-tubulin-glutamate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69072", "l": "H2O + O2 + serotonin = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873923", "l": "STARD10 binds LPCAT1 and PC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69013", "l": "5beta-dihydrotestosterone + H(+) + NADPH => 5beta-androstane-3beta,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622310", "l": "Activated NOD1 oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42892", "l": "5'-deoxyadenosine + H(+) + H2O = 5'-deoxyinosine + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.41", "l": "\"5'-deoxyadenosine deaminase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37580", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21386", "l": "(E)-cinnamate + NH4(+) => L-phenylalanine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19492", "l": "dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide <=> 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73730", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate <=> (2S,3R,11R)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426569", "l": "Interaction of DAP12 and IREM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38362", "l": "2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 <=> thiosulfate + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75145", "l": "solanapyrone D => prosolanapyrone III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9861667", "l": "DLAT trimer transfers acetyl to CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58352", "l": "2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202111", "l": "AKT1 phosphorylates eNOS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35429", "l": "(E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside => 1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001631", "l": "cysteinyl leukotriene receptor activity", "d": ["Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32206", "l": "(R)-synephrine <=> (4-hydroxyphenyl)acetaldehyde + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76427", "l": "(2R,9S)-annullatin H + A = (2R)-annullatin F + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57925", "l": "H2O + mutildienyl diphosphate => diphosphate + premutilin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806613", "l": "Keratin tetramers bind to form unit length filaments (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22518", "l": "ADP + H(+) + N-phosphotaurocyamine => ATP + taurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9858321", "l": "DHTKD1 dimer decarboxylates 2-OA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375140", "l": "CDO binds promyogenic cadherins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050540", "l": "2-aminomuconate deaminase activity", "d": ["Catalysis of the reaction: 2-aminomuconate + H2O + H+ = (Z)-5-oxohex-2-enedioate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202722", "l": "CD48 binds CD244 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78847", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + O2 = a very-long-chain (2E)-enoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0001875", "l": "lipopolysaccharide immune receptor activity", "d": ["Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36594", "l": "(S)-2-chloropropanoate + NADP(+) <=> 2-chloroacrylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49487", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18463", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69663", "l": "H2O + luteolin 7-O-beta-D-glucoside = beta-D-glucose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48497", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose => 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018715", "l": "9-phenanthrol UDP-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.-", "l": "\"Miscellaneous\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793955", "l": "Defective MGAT2 does not transfer GlcNAc to N-glycans (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17685", "l": "H(+) + uracil 5-carboxylate = CO2 + uracil", "d": [], "t": []}, {"i": "EC:4.1.1.66", "l": "\"uracil-5-carboxylate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9854463", "l": "SIRT3 deacetylates AcK-IDH2 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045300", "l": "acyl-[acyl-carrier-protein] desaturase activity", "d": ["Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61573", "l": "(11Z,14Z)-eicosadienoate + O2 => (15S)-hydroperoxy-(11Z,13E)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41220", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41610", "l": "2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha,alpha-trehalose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9006870", "l": "IL21 receptor STAT phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15855", "l": "17alpha-hydroxyprogesterone + H(+) + NADH => (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0034185", "l": "apolipoprotein binding", "d": ["Binding to an apolipoprotein, the protein component of a lipoprotein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693598", "l": "ATM phosphorylates NBN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40018", "l": "(+)-copalyl diphosphate + H2O <=> 13-epi-manool + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9824994", "l": "RPS6KA1-dependent phosphorylation of MITF-M (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22483", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) <=> 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1977959", "l": "ERBB4 forms heterodimers with EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44047", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> 11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0004046", "l": "aminoacylase activity", "d": ["Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24426", "l": "glutathione disulfide + L-ascorbate => 2 glutathione + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950766", "l": "IL27RA dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43776", "l": "an N-(acyl)-sphingosylphosphocholine(in) = an N-(acyl)-sphingosylphosphocholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5669240", "l": "FLNA binds PAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67655", "l": "dADP + H2O <=> 2'-deoxyadenosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168910", "l": "RIP1 facilitates IKK complex phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51602", "l": "3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646347", "l": "PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69340", "l": "(E)-prop-1-en-1-SO-peroxol = (Z)-propanethial S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17858", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60484", "l": "CTP + UTP = cyclic CMP-UMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190260", "l": "FGFR2b binds to FGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102718", "l": "TRIBOA-glucoside methyltransferase activity", "d": ["Catalysis of the reaction: TRIBOA-beta-D-glucoside + S-adenosyl-L-methionine = (2R)-DIMBOA glucoside + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373733", "l": "Neurofascin binds contactin-1:CASPR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647631", "l": "GSDMD (1-275) binds PIPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59053", "l": "D-lysine + H(+) => cadaverine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58764", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432129", "l": "FGR binds and phosphorylates LRP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42935", "l": "cytidine(32) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71525", "l": "adenine(in) => adenine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865275", "l": "PDGF-BB clevage by Furin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.36", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46634", "l": "7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+) => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.152", "l": "\"hydroperoxy icosatetraenoate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78618", "l": "ATP + H(+) + L-lysine <=> diphosphate + L-lysyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38271", "l": "(3S)-citramalyl-CoA = 3-methylfumaryl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.153", "l": "\"3-methylfumaryl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35656", "l": "2 ATP => 3',3'-c-di-AMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40681", "l": "1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382057", "l": "Release of novel PDGFs as latent factors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38099", "l": "a ribonucleoside 5'-triphosphate + phytyl phosphate = a ribonucleoside 5'-diphosphate + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873926", "l": "IFNG dimer binds IFNGR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35199", "l": "(S,S)-tartrate(out) = (S,S)-tartrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43495", "l": "7(1)-hydroxychlorophyll a + NADP(+) <=> chlorophyll b + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33781", "l": "6,6-kestotetraose + beta-D-glucose => 6-kestotriose + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51050", "l": "AH2 + androst-4-ene-3,17-dione => 5alpha-androstan-3,17-dione + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "58.747183398764925", "identifiers": [{"i": "GO:0016747", "l": "acyltransferase activity, transferring groups other than amino-acyl groups", "d": ["Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840564", "l": "OMA1 hydrolyzes YME1L1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070878", "l": "primary miRNA binding", "d": ["Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175258", "l": "2-LTR formation due to circularization of viral DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20824", "l": "adenosine + ATP = ADP + AMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.20", "l": "\"adenosine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376419", "l": "Formation of NR-MED1 Coactivator Complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0050833", "l": "pyruvate transmembrane transporter activity", "d": ["Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-372342", "l": "MPC1:MPC2 imports PYR, H+ to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834719", "l": "Synthesis of negative sense genomic RNA of respiratory syncytial virus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863463", "l": "STON2 binds SYT proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.-", "l": "\"CoA-transferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021609", "l": "ESR-associated SRC autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58148", "l": "ethyl acetate + H2O = acetate + ethanol + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.113", "l": "\"ethyl acetate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168923", "l": "Collagen type XVIII endostatin release (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40196", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071633", "l": "dihydroceramidase activity", "d": ["Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14719", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate => D-erythrose 4-phosphate + H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62726", "l": "(+)-isomalbrancheamide C + FADH2 => (+)-premalbrancheamide + bromide + FAD + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52723", "l": "5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O <=> 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0000339", "l": "RNA cap binding", "d": ["Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71585", "l": "L-histidine(out) + Na(+)(out) => L-histidine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40703", "l": "(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate = 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17563", "l": "acetate + choline + H(+) => acetylcholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39557", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560794", "l": "Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51154", "l": "3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide => 2 a thiol + L-cysteinyl-[sulfatase] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64285", "l": "2-phenylethylamine + pyruvate => 2-phenylacetaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72527", "l": "1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine = 1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102137", "l": "7-oxateasterone synthase activity", "d": ["Catalysis of the reaction: H+ + teasterone + NADPH + O2 = 7-oxateasterone + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57711", "l": "(E)-coniferaldehyde + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18984", "l": "(R)-pantolactone + NADP(+) <=> 2-dehydropantolactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051741", "l": "2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209828", "l": "Tryptophan is hydroxylated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173739", "l": "Spontaneous hydrolysis of C3 thioester (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824894", "l": "TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404139", "l": "HSC cytosolic atROL translocates to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19511", "l": "2 H(+) + L-erythro-biopterin + 2 NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694442", "l": "CNIH2,3 bind GRIA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2219524", "l": "PDPK1 binds PIP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59063", "l": "(20S)-ginsenoside Rg3 + H2O <=> (20S)-ginsenoside Rh2 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986937", "l": "MECP2 is phosphorylated at T308 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168947", "l": "Ligand binds to TLR10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047785", "l": "cortisol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + cortisol = adenosine 3',5'-diphosphate + cortisol 21-sulfate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704408", "l": "Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5591052", "l": "PROCR binds Protein C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35861", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42055", "l": "9-cis-retinol + NAD(+) <=> 9-cis-retinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30490", "l": "H(+) + N,N-dihydroxy-L-isoleucine <=> (1E,2S)-2-methylbutanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.320441548315301", "identifiers": [{"i": "GO:0004519", "l": "endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35265", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52766", "l": "(E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73552", "l": "GDP(out) + UTP(in) => GDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37872", "l": "2-heptyl-4(1H)-quinolone + H(+) + NADH + O2 => 2-heptyl-3-hydroxy-4(1H)-quinolone + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033813", "l": "deacetylcephalosporin-C acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49079", "l": "dibenzothiophene + FMNH2 + O2 <=> dibenzothiophene 5-oxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018487", "l": "vanillate O-demethylase (anaerobic) activity", "d": ["Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668904", "l": "Formation of the CTF18 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010356", "l": "homogentisate geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: (2E,6E,10E)-geranylgeranyl diphosphate + H+ + homogentisate = 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2272795", "l": "Interaction of DAP12 and KIR2DS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67917", "l": "adenosine 5'-phosphoramidate + H2O => AMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623365", "l": "Expression of MYLIP regulated by NR1H2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54752", "l": "methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n) = dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}, {"i": "EC:1.5.98.3", "l": "\"coenzyme F420:methanophenazine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74718", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine <=> 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23607", "l": "kievitone hydrate <=> H2O + kievitone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35333", "l": "(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0019003", "l": "GDP binding", "d": ["Binding to GDP, guanosine 5'-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031435", "l": "mitogen-activated protein kinase kinase kinase binding", "d": ["Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446221", "l": "GMPPB converts Mannose-1-phosphate to GDP-Mannose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046562", "l": "glucose oxidase activity", "d": ["Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2482180", "l": "Collagen type VIII degradation by ELANE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21138", "l": "CoA + O-acetyl-(R)-carnitine => (R)-carnitine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419426", "l": "Cannabinoid receptors can bind cannabinoids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67780", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20333", "l": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32175", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59363", "l": "carnosine + H2O <=> beta-alanine + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693148", "l": "BCKDK phosphorylates BCKDH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0019210", "l": "kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201669", "l": "Beta-catenin translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34286", "l": "2 L-tyrosine + O2 <=> 2 L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77945", "l": "1,3-di-(9Z)-hexadecenoylglycerol + 9-(9Z-hexadecenoyloxy)-octadecanoate => 1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43588", "l": "a globoside NORint + UDP-alpha-D-galactose = a globoside NOR2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29619", "l": "alpha-maltotetraose + beta-maltose = alpha-maltopentaose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1449687", "l": "Corticosteroids bind to CBG in blood (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48819", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 <=> 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.33584335509623", "identifiers": [{"i": "GO:0016775", "l": "phosphotransferase activity, nitrogenous group as acceptor", "d": ["Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950175", "l": "Expression of Glutathione S-transferase omega-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11267", "l": "H(+) + NADH + O2 <=> H2O2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471322", "l": "Beta-defensins are secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.18", "l": "\"meprin A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36259", "l": "a 1-(1-hydroxyalkyl)-sn-glycerol = an aldehyde + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198756", "l": "ERK1/2 phosphorylates MSK1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793485", "l": "PRKN polyubiquitinates RIPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19748", "l": "3,3',5-triiodo-L-thyronine + A + H(+) + iodide <=> AH2 + L-thyroxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16620", "l": "beta-D-glucosyl-(1->3)-D-glucose + phosphate <=> alpha-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656893", "l": "OPN1MW binds 11cRAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13283", "l": "2-methyl-3-oxobutanoyl-CoA + H(+) + NADH => (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72721", "l": "AMP + 2 H(+) + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein] => L-lysyl-[lipoyl-carrier protein] + N(6)-[(R)-dihydrolipoyl]-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042973", "l": "glucan endo-1,3-beta-D-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9833973", "l": "ISGylation of PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31513", "l": "chenodeoxycholate + CoA + H(+) => chenodeoxycholoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129362", "l": "Fibrillin microfibril assembly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43111", "l": "2 Fe(III)-[cytochrome c] + H2O + N2 <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37370", "l": "CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine <=> 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169398", "l": "ISGylation of host protein filamin B (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2248891", "l": "M6PR transports activated ARSA to the lysosome (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937419", "l": "CBR3 reduces DOX to DOXOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085992", "l": "SUMOylation of DAXX with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694304", "l": "nsp14 binds nsp12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70262", "l": "AMP(out) + phosphate(in) <=> AMP(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59881", "l": "4-hydroxyphenylacetate + FMNH2 + O2 => 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667456", "l": "AVPR1A,B bind desmopressin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25900", "l": "D-arabino-hex-3-ulose 6-phosphate = beta-D-fructose 6-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.27", "l": "\"6-phospho-3-hexuloisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37907", "l": "(9Z)-octadecenoate + O2 = (8E,10S)-10-hydroperoxy-octadeca-8-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32959", "l": "H2O + L-isoleucine + NAD(+) = (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52794", "l": "Mg(2+) + pheophorbide a => chlorophyllide a + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29511", "l": "(2E,6E)-farnesyl diphosphate = (+)-valencene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.73", "l": "\"valencene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218812", "l": "FYN phosphorylates PAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62858", "l": "GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59981", "l": "8-oxo-dGTP + H2O => 8-oxo-dGDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19486", "l": "sphing-4-enine + UDP-alpha-D-galactose => beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.2.2", "l": "\"oxazoline synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034319", "l": "alcohol O-butanoyltransferase activity", "d": ["Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22835", "l": "H2O + N-formimidoyl-L-glutamate <=> N-formyl-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52734", "l": "adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+) => 3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167633", "l": "Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73756", "l": "2 H(+)(out) + histamine(in) => 2 H(+)(in) + histamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51247", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56680", "l": "beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.27", "l": "\"beta-dihydromenaquinone-9 omega-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26005", "l": "D-arabinitol 1-phosphate + NAD(+) <=> D-xylulose 5-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047813", "l": "D-arabinitol 4-dehydrogenase activity", "d": ["Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34459", "l": "8-hydroxycopalyl diphosphate + H2O = diphosphate + sclareol", "d": [], "t": []}, {"i": "EC:4.2.3.141", "l": "\"sclareol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47936", "l": "4-hydroxybenzaldehyde + H2O + NADP(+) = 4-hydroxybenzoate + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.96", "l": "\"4-hydroxybenzaldehyde dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791109", "l": "GADD45A binds PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709454", "l": "EPOR binds EPOR agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018474", "l": "2-carboxybenzaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38645", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003835", "l": "beta-galactoside alpha-2,6-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactoside = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032563", "l": "dADP binding", "d": ["Binding to dADP, deoxyadenosine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47719", "l": "4-pregnen-20,21-diol-3-one + NAD(+) <=> 21-hydroxyprogesterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850786", "l": "SPINK6 binds KLK12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31088", "l": "acetyl-CoA + octanoyl-CoA => 3-oxodecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65326", "l": "chrodrimanin B + CoA => acetyl-CoA + chrodrimanin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855232", "l": "RELN:VLDLR binds DAB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9834945", "l": "PINK1 phosphorylates Ub on MOM proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180024", "l": "membrane grommet activity", "d": ["An activity in which a protein, or group of proteins, acts to restrict the size of a fenestration in a membrane or membrane system (i.e. restrict the diameter of a hole in a membrane). An example of this is the molecular function is performed by ESCRT-III proteins at the nuclear envelope of fission yeast during anaphase B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.213", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60683", "l": "(+)-artemisinic aldehyde + H2O + NADP(+) <=> (+)-artemisinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43021", "l": "L,L-cystathionine => 2-aminoprop-2-enoate + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62798", "l": "aurasperone A + 2 H2O + NADP(+) => H(+) + NADPH + O2 + 2 rubrofusarin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983427", "l": "Expression of peptide bound class I MHC on cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806613", "l": "Keratin tetramers bind to form unit length filaments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17521", "l": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.5.7", "l": "\"glutaminyl-tRNA synthase (glutamine-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14308", "l": "ATP + L-proline + tRNA(Pro) <=> AMP + diphosphate + L-prolyl-tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76169", "l": "glycyl-L-leucine + 2 H(+)(in) => glycyl-L-leucine(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76745", "l": "7-tetradecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58695", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV <=> FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354097", "l": "Activation of Talin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66752", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O = (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72893", "l": "acetylcholine(in) + 2 H(+)(out) => acetylcholine(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67684", "l": "a long-chain fatty acid(in) + ATP + H2O = a long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31973", "l": "10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+) => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46354", "l": "3-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65106", "l": "aculene B + holo-[peptidyl-carrier protein] => aculene D + L-prolyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15598", "l": "a Fe(III)-siderophore(out) + ATP + H2O => a Fe(III)-siderophore(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-451418", "l": "Pellino ubiquitinates IRAK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55527", "l": "H(+) + H2O + L-dopa + O2 <=> 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47318", "l": "(2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202713", "l": "CD84 homodimerises (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25674", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.78", "l": "\"phosphatidylinositol-4,5-bisphosphate 4-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183052", "l": "CBL binds to GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102897", "l": "abietadienal hydroxylase activity", "d": ["Catalysis of the reaction: abietal + NADPH + O2 = abietate + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419003", "l": "Interaction of Nectins with Afadin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40596", "l": "dodecanedioyl-CoA + H2O => CoA + dodecanedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709360", "l": "H2O2 reduces MetHb (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77813", "l": "(2S)-3-methyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]butanoate + H(+) + H2O2 => N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-valine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42642", "l": "a menaquinol + H(+) + S-adenosyl-L-homocysteine => a 2-demethylmenaquinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935960", "l": "RUNX1 binds the TJP1 (ZO-1) gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63298", "l": "H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine => an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26262", "l": "H2O + isopimara-7,15-dienal + NADP(+) => 2 H(+) + isopimarate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64516", "l": "2-hydroxyethane-1-sulfonate + NAD(+) = H(+) + NADH + sulfoacetaldehyde", "d": [], "t": []}, {"i": "EC:1.1.1.433", "l": "\"sulfoacetaldehyde reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45457", "l": "H2O + N-dodecanoylethanolamine => dodecanoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57499", "l": "2-methylcitrate <=> 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103059", "l": "UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol oxoanion + UDP-L-rhamnose = H+ + kaempferol-3-rhamnoside + UDP(3-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017921", "l": "OPRM1 gene expression is repressed by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032761", "l": "DOCK3 binds FYN associated with NTRK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31183", "l": "acetyl-CoA + decanoyl-CoA = 3-oxododecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21472", "l": "ATP + citrate + CoA = (3S)-citryl-CoA + ADP + phosphate", "d": [], "t": []}, {"i": "EC:6.2.1.18", "l": "\"citrate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102473", "l": "eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity", "d": ["Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose = 8C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP(3-) + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050580", "l": "2,5-didehydrogluconate reductase activity", "d": ["Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22850", "l": "3-oxooctanedioyl-CoA + H(+) + NADH => (3S)-hydroxyoctanedioyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047754", "l": "choline sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + choline = adenosine 3',5'-diphosphate + choline sulfate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047341", "l": "fucose-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP + H+ = diphosphate + GDP-beta-L-fucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50370", "l": "3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+) => 2-methylbutan-2-ol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58355", "l": "2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26310", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O => 1,4-dihydroxy-2-naphthoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22195", "l": "(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide <=> (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70966", "l": "D-phenylalanine + H2O + O2 <=> 3-phenylpyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58647", "l": "N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine <=> (9Z,12Z,15Z)-octadecatrienamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863494", "l": "ASICs bind STOML3, (STOM) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782943", "l": "UV-DDB ubiquitinates XPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50393", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline => 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193646", "l": "NGF binding to p75NTR inactivates RHOA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59404", "l": "L-homoserine = D-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50438", "l": "prostaglandin E1 => prostaglandin H1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18947", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[collagen] => 2-oxoglutarate + L-prolyl-[collagen] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73261", "l": "eupatorin + H(+) + S-adenosyl-L-homocysteine => cirsiliol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12839", "l": "ADP + H(+) + phosphocholine => ATP + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140584", "l": "chromatin extrusion motor activity", "d": ["A DNA translocase activity that folds chromosomal DNA and catalytically extends the newly formed loop, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59054", "l": "cadaverine + CO2 => D-lysine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30154", "l": "FADH2 + NADP(+) <=> FAD + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138459", "l": "WNT5A:FZD4 is endocytosed (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54938", "l": "decanoyl-[ACP] + NAD(+) => (2E)-decenoyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.237", "l": "\"hydroxyphenylpyruvate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58811", "l": "2',3'-cGAMP + 2 H2O <=> AMP + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759892", "l": "Expression of BMP4 in lateral plate mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44061", "l": "2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65948", "l": "a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 = A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34411", "l": "cannabigerolate + O2 = cannabidiolate + H2O2", "d": [], "t": []}, {"i": "EC:1.21.3.8", "l": "\"cannabidiolic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003939", "l": "L-iditol 2-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+. Acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853319", "l": "FGFR2 fusions dimerize (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35226", "l": "2-oxo-dADP + H2O <=> 2-oxo-dAMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42091", "l": "all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051075", "l": "S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity", "d": ["Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45256", "l": "hexadecanoate(out) = hexadecanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36667", "l": "(15Z)-tetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52106", "l": "an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+) => a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663170", "l": "p-BMAL1:p-CLOCK,NPAS2 binds BHLHE40 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56641", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10550", "l": "4-guanidinobutanamide + CO2 + H2O => L-arginine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950504", "l": "IL27 binds CRLF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033808", "l": "6'-deoxychalcone synthase activity", "d": ["Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47367", "l": "a dodecanoate ester + H2O <=> an aliphatic alcohol + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78138", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol <=> a 1,3-diacylglycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76919", "l": "4-methyl-cyclohexylamine + H2O + NADP(+) = 4-methylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20138", "l": "10-deacetylbaccatin III + acetyl-CoA => baccatin III + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31189", "l": "3-oxodecanoyl-CoA + H(+) + NADH => (3S)-hydroxydecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75141", "l": "asukamycin + H2O + NAD(+) => 4-hydroxyprotoasukamycin + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55742", "l": "D-glucose + oleuropein aglycone => H2O + oleuropein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430158", "l": "p-SLP-76 binds VAV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11662", "l": "acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75447", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0070259", "l": "tyrosyl-DNA phosphodiesterase activity", "d": ["Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61582", "l": "(5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH => (3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202164", "l": "Translocation of PDK1 to Plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25118", "l": "H2O + L-lysine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666458", "l": "IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015515", "l": "citrate:succinate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out)."], "t": []}, {"i": "RHEA:28835", "l": "citrate(out) + succinate(in) = citrate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58856", "l": "(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-oxogeraniol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031527", "l": "Expression of APOC2 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19220", "l": "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane <=> 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73152", "l": "CoA(out) + FMN(in) => CoA(in) + FMN(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0140996", "l": "histone H3 kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71384", "l": "L-asparagine(in) + Na(+)(in) => L-asparagine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4827388", "l": "CTNNB1 S45 mutants aren't phosphorylated by CK1alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65150", "l": "H(+) + trilobatin + UDP => phloretin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24847", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O <=> 2 isomaltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21255", "l": "(S)-2-hydroxyglutarate + A <=> 2-oxoglutarate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17145", "l": "2'-hydroxy-2,3-dihydrodaidzein + NADP(+) = 2'-hydroxydaidzein + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.51", "l": "\"2'-hydroxydaidzein reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13447", "l": "(R)-pantothenate + cysteamine => (R)-pantetheine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53035", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218642", "l": "PTK2 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23512", "l": "alpha,alpha-trehalose + phosphate = beta-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.64", "l": "\"alpha,alpha-trehalose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22955", "l": "O2 + octanedioyl-CoA <=> (2E)-octenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57906", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.1.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218820", "l": "Src kinases phosphorylate VAV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17131", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate => ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68053", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O => a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5263628", "l": "CAV3:TRIM72:DYSF binds ANXAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69168", "l": "H2O + NAD(+) + spermine monoaldehyde = 2 H(+) + N-(2-carboxyethyl)spermidine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63578", "l": "ecdysone + phosphate => ecdysone 22-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950721", "l": "Expression of Programmed cell death protein 4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950583", "l": "STAT3 binds to p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53865", "l": "3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) => 7,12-dioxo-lithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31506", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate <=> 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12850", "l": "H2O + O-phospho-L-seryl-[myosin light chain] => L-seryl-[myosin light chain] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36417", "l": "diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840949", "l": "ARSA removes sulfate from SM3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39317", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13768", "l": "bromochloromethane + H2O <=> bromide + chloride + formaldehyde + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24869", "l": "5'-deoxyadenosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6794347", "l": "Homer1,2,3 dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008974", "l": "phosphoribulokinase activity", "d": ["Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24318", "l": "(+)-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69204", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate = ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2299620", "l": "Collagen XI cross-links with collagen II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112727", "l": "Serine phosphorylation of STATs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33543", "l": "ergosteryl palmitate + H2O = ergosterol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56644", "l": "a uridine in mRNA = a pseudouridine in mRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592252", "l": "Expression of TFB2M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433506", "l": "Phosphorylation of APS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46408", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11074", "l": "catechol + CO2 + NADP(+) + NH4(+) => anthranilate + 3 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106370", "l": "protein-L-histidine N-pros-methyltransferase activity", "d": ["Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine."], "t": []}, {"i": "RHEA:67076", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine = H(+) + N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64941", "l": "dGDP + H2O => dGMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853444", "l": "AURKA phosphorylates PHLDA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49171", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66541", "l": "7-dehydrocholesterol + A + H2O => AH2 + cholesta-5,7-dien-3beta,25-diol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9846305", "l": "ST6GALNAC5,6 transfer Neu5Ac to GM1b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42057", "l": "13-cis-retinol + NAD(+) => 13-cis-retinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "45.853912211310032", "identifiers": [{"i": "GO:0015267", "l": "channel activity", "d": ["Enables the energy-independent facilitated diffusion of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23632", "l": "D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48215", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45581", "l": "D-galactaro-1,5-lactone => D-galactaro-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76053", "l": "(S)-cis-N-methylscoulerine + S-adenosyl-L-homocysteine => (S)-scoulerine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.042693372152272", "identifiers": [{"i": "GO:0015925", "l": "galactosidase activity", "d": ["Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34462", "l": "8-hydroxycopalyl diphosphate + H2O <=> diphosphate + sclareol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.21", "l": "\"primary-amine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218820", "l": "Src kinases phosphorylate VAV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102165", "l": "(Z)-3-hexen-1-ol acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + (Z)-hex-3-en-1-ol = (3Z)-hex-3-en-1-yl acetate + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112150", "l": "RNA Polymerase III Promoter Opening at Type 2 Promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163310", "l": "TFAM binds to mitochondrial promoters (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59432", "l": "3-hydroxypropanal + H2O + NAD(+) = 3-hydroxypropanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63214", "l": "5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9865663", "l": "MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863973", "l": "Fusion of ERC and phagosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22208", "l": "3-hydroxyphenylacetate + H(+) + NADH + O2 = H2O + homogentisate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195304", "l": "Association of beta-catenin with the destruction complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55152", "l": "H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] = (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.14", "l": "\"L-prolyl-[peptidyl-carrier protein] dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63768", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43918", "l": "(25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75850", "l": "Addition of the third nucleotide on the nascent transcript (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14829", "l": "hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine", "d": [], "t": []}, {"i": "EC:2.5.1.47", "l": "\"cysteine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018588", "l": "tri-n-butyltin dioxygenase activity", "d": ["Catalysis of the reaction: tri-n-butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71805", "l": "acetate(in) + H(+)(in) => acetate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.25", "l": "\"unsaturated pyranuronate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14421", "l": "H2O + N(2)-benzoyl-D-arginine-4-nitroanilide = 4-nitroaniline + H(+) + N(2)-benzoyl-D-arginine", "d": [], "t": []}, {"i": "EC:3.5.1.72", "l": "\"D-benzoylarginine-4-nitroanilide amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31295", "l": "(2E)-2-hydroxypenta-2,4-dienoate = 2-oxopent-4-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654510", "l": "FGFRL1 binds SPRED1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74962", "l": "(3R)-3-isocyanylbutanoate + ATP + holo-[ACP] <=> (3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443779", "l": "Linkage of L1 with treadmilling F-actin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912734", "l": "CBL:CRKL binds RAPGEF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53051", "l": "2-hydroxyestrone + UDP-alpha-D-glucuronate <=> 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38831", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134914", "l": "Beta-catenin migrates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77285", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.120", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013147", "l": "RAC1 GDIs block activation of RAC1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198958", "l": "KIR2DL2/3 interacting with HLA-C group 1 (Cw4) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63639", "l": "a medium-chain fatty acyl-AMP + holo-[ACP] <=> a medium-chain fatty acyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60318", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41239", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]-acylsphin-4-enine + O2 = N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56690", "l": "(2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate => (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297444", "l": "Binding of cAMP to HCN channels (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684169", "l": "G6B binds PTPN6,PTPN11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043883", "l": "malolactic enzyme activity", "d": ["Catalysis of the reaction: malate + H+ = L-lactate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57290", "l": "a guanosine in RNA + H(+) + lactate => an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36421", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10350", "l": "ADP + H(+) + L-glutamate + phosphate => 5-oxo-L-proline + ATP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006873", "l": "IL21 receptor STAT binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26402", "l": "all-trans-10'-apo-beta-carotenal + O2 => (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49907", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58992", "l": "(E)-cinnamaldehyde + H2O + O2 = (E)-cinnamate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12410", "l": "2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+) => L-lysine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.474722737186141", "identifiers": [{"i": "GO:0005183", "l": "gonadotropin hormone-releasing hormone activity", "d": ["The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43573", "l": "A + D-arginine + H2O => 5-guanidino-2-oxopentanoate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29217", "l": "menaquinone-8 + succinate => fumarate + menaquinol-8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35217", "l": "H(+) + phosphate + XMP => H2O + XDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44211", "l": "12-methyltridecanoate + ATP + CoA <=> 12-methyltridecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58296", "l": "25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine = 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63106", "l": "16-hydroxy-ilicicolin A epoxide + H2O + NADP(+) => H(+) + ilicicolin A epoxide + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10664", "l": "NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde", "d": [], "t": []}, {"i": "EC:1.1.1.144", "l": "\"perillyl-alcohol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33755", "l": "H2O + N-hexadecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34703", "l": "(2E,6E)-farnesyl diphosphate = (E)-2-epi-beta-caryophyllene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.137", "l": "\"(E)-2-epi-beta-caryophyllene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54542", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein] => H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869568", "l": "NPM1 binds TFAP2A homodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9854405", "l": "Frataxin transfers Fe2+ to ACO2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047723", "l": "inosinate nucleosidase activity", "d": ["Catalysis of the reaction: H2O + IMP = D-ribose 5-phosphate + hypoxanthine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34536", "l": "H(+) + hexadecanoyl-CoA + L-alanine => 1-deoxy-3-dehydrosphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380239", "l": "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173709", "l": "C7 binds C5b:C6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75423", "l": "(R,S)-butane-2,3-diol + NAD(+) = (R)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64922", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate => a 2'-deoxyribonucleoside 5'-diphosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70138", "l": "6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18427", "l": "3-dehydroquinate + H(+) + NADPH => L-quinate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047932", "l": "glucosamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: D-glucosamine + acetyl-CoA = N-acetyl-D-glucosamine + CoA + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12445", "l": "hexadecanal + NADP(+) => (2E)-hexadecenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25314", "l": "glycolate + O2 <=> glyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201603", "l": "Caspase-mediated cleavage of PKC theta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77716", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside IV(3)-alpha-NeuNAc,III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684071", "l": "RNF4 ubiquitinates MDC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61360", "l": "ATP + H2O + pheophorbide a(in) = ADP + H(+) + pheophorbide a(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35240", "l": "tetracycline(in) => tetracycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12761", "l": "precorrin-3B + S-adenosyl-L-methionine = 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.131", "l": "\"precorrin-3B C(17)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28274", "l": "(S)-S-adenosyl-L-methionine = (R)-S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30643", "l": "phosphate + S-methyl-5'-thioinosine = hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.4.2.44", "l": "\"S-methyl-5'-thioinosine phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71775", "l": "SUCLG1/G2 cleaves succinyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20081", "l": "H2O + N-methylhexanamide = hexanoate + methylamine", "d": [], "t": []}, {"i": "EC:3.5.1.39", "l": "\"alkylamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210294", "l": "Interaction of PECAM-1 and SHP-2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392870", "l": "Gs activation by prostacyclin receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77841", "l": "2-dehydro-D-glucose + L-glutamate => (2S)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]pentanedioate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.2", "l": "\"dipeptidyl-peptidase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43954", "l": "H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate => 3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44197", "l": "3-methylundecanoate + ATP + CoA => 3-methylundecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15828", "l": "AZD1979 + H2O <=> AZD1979 oxetane hydrolysis product + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031810", "l": "H4 histamine receptor binding", "d": ["Binding to a H4 histamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20795", "l": "ATP + L-lysine + tRNA(Lys) <=> AMP + diphosphate + L-lysyl-tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50475", "l": "anthraniloyl-CoA + H(+) + malonyl-CoA <=> (2-aminobenzoyl)acetyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9823906", "l": "TBK1 is phosphorylated within the activated TLR4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60011", "l": "a tRNA precursor + 2 CTP <=> a tRNA with a 3' CC end + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74006", "l": "A + peniprequinolone <=> AH2 + yaequinolone E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55239", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O <=> (9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78725", "l": "3-dehydro-D-glucose + D-glucose => 3'-dehydromaltose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20355", "l": "AH2 + tetrachloroethene => A + chloride + H(+) + trichloroethene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13239", "l": "D-glucosamine 6-phosphate + L-glutamate => D-fructose 6-phosphate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42674", "l": "gamma-L-glutamyl-hercynylcysteine S-oxide + H2O => gamma-L-glutamyl-L-cysteine + hercynine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840807", "l": "OPTN binds ATG9A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24551", "l": "an N(6)-acyl-L-lysine + H2O <=> a carboxylate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003876", "l": "AMP deaminase activity", "d": ["Catalysis of the reaction: AMP + H2O = IMP + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018672", "l": "anthranilate 3-monooxygenase (deaminating) activity", "d": ["Catalysis of the reaction: anthranilate + 2 H+ + NADPH + O2 = 2,3-dihydroxybenzoate + NADP+ + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031826", "l": "type 2A serotonin receptor binding", "d": ["Binding to a type 2A serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5591052", "l": "PROCR binds Protein C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56978", "l": "4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin] => 4-methylphenol + H2O + 2 oxidized [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70912", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate => (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70971", "l": "ACO2 isomerizes citrate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70052", "l": "2-oxoadipate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018807", "l": "RAC3 GDIs block activation of RAC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70528", "l": "H(+) + N-acyl-3-oxosphinganine + NADH => an N-acylsphinganine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68960", "l": "7,8-dihydroxycoumarin + S-adenosyl-L-methionine = 7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180599", "l": "The Vpu:CD4:beta-TrCP complex recruits SKP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12005", "l": "indoxyl + UDP-alpha-D-glucose => H(+) + indican + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59229", "l": "6-sulfo-alpha-D-quinovose => 6-sulfo-beta-D-quinovose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54241", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38502", "l": "a triacyl-sn-glycerol + H2O <=> a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43880", "l": "(25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA = (25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40680", "l": "(9Z)-octadecen-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z)-octadecenylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047383", "l": "guanidinodeoxy-scyllo-inositol-4-phosphatase activity", "d": ["Catalysis of the reaction: 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35579", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8 = anthocyanin A11 + D-glucose", "d": [], "t": []}, {"i": "EC:2.3.1.n12", "l": "\"sinapoyl-beta-D-glucose:anthocyanin sinapoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76527", "l": "2'-deoxyguanosine + H(+) + H2O = 2'-deoxyxanthosine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39422", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050246", "l": "questin monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + questin = demethylsulochrin + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58235", "l": "L-seryl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866941", "l": "MID1IP1 binds THRSP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694441", "l": "3CLp cleaves pp1a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5591086", "l": "SERPINA5 binds activated protein C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9825783", "l": "p-S207 KARS1 dimer translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013889", "l": "TLR3-induced ripoptosome assembly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351913", "l": "Caspase-mediated cleavage of TJP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52944", "l": "cholate + UDP-alpha-D-glucuronate = choloyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013145", "l": "RAC1 binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19357", "l": "H(+) + L-proline betaine + NADPH + O2 = formaldehyde + H2O + N-methyl-L-proline + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33525", "l": "acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) => ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61867", "l": "AH2 + dehydroprobetaenone I <=> A + probetaenone I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11921", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin => (6R)-L-erythro-6,7-dihydrobiopterin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854052", "l": "Formation of the SCF-FBXL7 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621042", "l": "TF gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047646", "l": "alkanal monooxygenase (FMN-linked) activity", "d": ["Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54200", "l": "N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28904", "l": "D-alanine(in) + H(+)(in) => D-alanine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195251", "l": "Assembly of the destruction complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48209", "l": "H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54758", "l": "AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide => deamido-NAD(+) + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22863", "l": "ATP + H(+) + nicotinate beta-D-ribonucleotide <=> deamido-NAD(+) + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58459", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O <=> (R)-glycerate + D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41039", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37659", "l": "anthraniloyl-CoA + methanol = CoA + O-methyl anthranilate", "d": [], "t": []}, {"i": "EC:2.3.1.232", "l": "\"methanol O-anthraniloyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870466", "l": "RGGT:CHM binds RABs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22860", "l": "ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.18", "l": "\"nicotinate-nucleotide adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097372", "l": "NAD-dependent histone H3K18 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42466", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+) => biphenyl-2,2',3-triol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12845", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate", "d": [], "t": []}, {"i": "EC:3.4.15.6", "l": "\"cyanophycinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937814", "l": "RUNX3 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51642", "l": "(11R)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40343", "l": "3-oxohexadecanedioyl-CoA + CoA = acetyl-CoA + tetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22359", "l": "diphosphate + oxaloacetate <=> CO2 + phosphate + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22492", "l": "H2O + N-formimidoyl-L-glutamate = formamide + L-glutamate", "d": [], "t": []}, {"i": "EC:3.5.3.8", "l": "\"formimidoylglutamase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170016", "l": "endoplasmic reticulum-endosome tether activity", "d": ["The binding activity of a molecule that brings together an endosome and an ER membrane either via membrane lipid binding or by interacting with an endosome protein, to establish and facilitate organelle exchange."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051506", "l": "ergosterol UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + ergosterol = UDP + O-glucosyl-ergosterol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237129", "l": "Acireductone is created (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700120", "l": "PTN and MDK bind to PTPRZ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35780", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => mutildienyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69685", "l": "CHEK2 phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714481", "l": "RAC2 binds effectors at the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938121", "l": "SERPINB13 binds CTSK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39299", "l": "(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714483", "l": "RAC2 translocates to the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714580", "l": "SLC6A3 binds DRIs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.71648590403835", "identifiers": [{"i": "GO:0003720", "l": "telomerase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426223", "l": "Cation influx mediated by TRPC3/6/7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48936", "l": "2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66494", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74106", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56722", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => 2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57204", "l": "glyoxal + L-lysyl-[protein] = N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55987", "l": "(R)-mandelonitrile + UDP-alpha-D-glucose <=> (R)-prunasin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30091", "l": "a ubiquinone + D-alanine + H2O = a ubiquinol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36145", "l": "hexadecanoyl-CoA + NADP(+) => (2E)-hexadecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71456", "l": "goralatide + H2O => L-lysyl-L-proline + N-acetyl-L-seryl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65784", "l": "2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36576", "l": "(9Z)-octadecenoyl-CoA + sphinganine => CoA + H(+) + N-(9Z-octadecenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20431", "l": "acacetin + H(+) + S-adenosyl-L-homocysteine => apigenin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033592", "l": "RNA strand annealing activity", "d": ["An activity that facilitates the formation of a complementary double-stranded RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32497", "l": "(6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51551", "l": "(S)-tetrahydropapaverine + S-adenosyl-L-methionine <=> (S)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72330", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate <=> 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25081", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) <=> 4-methyl-2-oxopentanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.154", "l": "\"fructan beta-(2,6)-fructosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31560", "l": "L-galactose + NAD(+) => H(+) + L-galactono-1,4-lactone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0044620", "l": "ACP phosphopantetheine attachment site binding", "d": ["Binding to the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682012", "l": "ATG5:ATG12 binds ATG16L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.43", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60841", "l": "a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48244", "l": "a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78753", "l": "a fatty acyl-L-carnitine + CoA => (R)-carnitine + a fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140989", "l": "7-deoxyloganate 7-hydroxylase activity", "d": ["Catalysis of the reaction: 7-deoxyloganate + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O + loganate + oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.2", "l": "\"ABC-type nonpolar-amino-acid transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034532", "l": "2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate = 2-hydroxy-4-hydroxymethylbenzalpyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874685", "l": "CBL binds MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-179410", "l": "Association of Nek2A with MCC:APC/C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33039", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin = 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12306", "l": "2 H(+) + L-2-aminoadipate + NADPH => (S)-2-amino-6-oxohexanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609921", "l": "SGTA binds Tail-anchored protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001852", "l": "complement component iC3b binding", "d": ["Binding to a iC3b product of the complement cascade."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199046", "l": "Ligands bind L-selectin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17622", "l": "acetyl-CoA + citramalate => (3S)-citramalyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28899", "l": "glycine(in) + H(+)(in) = glycine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57538", "l": "a 5'-end NTP-ribonucleotide-RNA + AMP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31118", "l": "ATP + biotin + H(+) <=> biotinyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56689", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 => (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36922", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050647", "l": "5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding", "d": ["Binding to 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37835", "l": "aklavinone + H(+) + NADPH + O2 = epsilon-rhodomycinone + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.180", "l": "\"aklavinone 12-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19241", "l": "ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] = ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76065", "l": "3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in) => 3'-phosphoadenylyl sulfate(in) + adenosine 3',5'-bisphosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46876", "l": "[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate = [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.33", "l": "\"mannuronan synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10314", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) => H(+) + NADH + O2 + terephthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56127", "l": "A + all-trans-lycopene + dimethylallyl diphosphate + H2O <=> AH2 + diphosphate + nonaflavuxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60252", "l": "(S)-methylmalonyl-CoA + NADP(+) = acryloyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18540", "l": "H2O + NAD(+) + salicylaldehyde <=> 2 H(+) + NADH + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.60", "l": "\"caspase-7\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72884", "l": "2 3-phenylpyruvate + 2 ATP => 2 AMP + 2 diphosphate + H(+) + polyporic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050462", "l": "N-acetylneuraminate synthase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686578", "l": "Activated ATM phosphorylates ABL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10129", "l": "all-trans-violaxanthin => all-trans-neoxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.209", "l": "\"3(or 17)alpha-hydroxysteroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043814", "l": "phospholactate guanylyltransferase activity", "d": ["Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985943", "l": "p-Y701-STAT1 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74337", "l": "O-2-methylbutanoyl-(R)-carnitine(out) => O-2-methylbutanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632653", "l": "Hh-Npp binds BOC:PTCH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14512", "l": "2-oxoglutarate + mugineate + O2 <=> 3-epihydroxymugineate + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10670", "l": "1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.48", "l": "\"uridine/cytidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381668", "l": "cAMP activates EPAC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983156", "l": "Polyubiquitination of substrate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34879", "l": "2 H2O + methyl 3-cyano-2-phenylpropanoate = 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987214", "l": "p-STAT3 dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102445", "l": "3-methylquercetin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5-trihydroxy-3-methoxyflavon-7-olate + S-adenosyl-L-methionine = 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41029", "l": "1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37111", "l": "(15Z)-tetracosenoyl-CoA + sphing-4-enine = CoA + H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77211", "l": "3'-phosphoadenylyl sulfate + taurodeoxycholate = 3alpha-sulfotaurodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811508", "l": "ING2-bound EP300 acetylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25345", "l": "H2O + urea <=> carbamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46181", "l": "2-methylbutanoate + ATP + CoA => 2-methylbutanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22453", "l": "[phosphate](n+1) + n H2O => n H(+) + (n+1) phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674414", "l": "Sorafenib-resistant PDGFR mutants don't bind sorefenib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58726", "l": "H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine => adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28180", "l": "colnelenate + H2O => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0089721", "l": "phosphoenolpyruvate transmembrane transporter activity", "d": ["Enables the transfer of a phosphoenolpyruvate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419277", "l": "GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982637", "l": "Opsins binds G alpha-t (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41379", "l": "1-O-decyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-decyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419490", "l": "Binding of ATP to P2X receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27537", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58557", "l": "15alpha-stemmadenine intermediate II + H2O => (16S)-deshydroxymethyl-stemmadenine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61221", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70409", "l": "(2E,6E,10E)-geranylgeranial + H2O2 + L-cysteine => [(2E,6E,10E)-geranylgeranyl]-L-cysteine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77227", "l": "AH2 + gentamicin X2 + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + A + geneticin + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.390", "l": "\"gentamicin X2 methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60056", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 = a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39717", "l": "(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47497", "l": "lithocholate + NADP(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47220", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23032", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.3.1", "l": "\"phosphoribosylformylglycinamidine cyclo-ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654511", "l": "FGFRL1 dimer binds FGFs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19616", "l": "dimethyl sulfide + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + trimethylsulfonium", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46721", "l": "(3R)-hydroxyhexanoyl-CoA => (2E)-hexenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190682", "l": "Connexin synthesis (generic) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37287", "l": "ATP + H2O + L-alanyl-L-leucine(out) = ADP + H(+) + L-alanyl-L-leucine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24566", "l": "a 3-oxoacyl-CoA + succinate => a 3-oxo acid + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013985", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70185", "l": "alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose => 2 alpha-isomaltosyl-(1->4)-D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047094", "l": "3-hydroxyphenylacetate 6-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39109", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70880", "l": "L-glutamine(in) + L-threonine(out) + Na(+)(out) => L-glutamine(out) + L-threonine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961863", "l": "E2F1 binds the DHFR gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14720", "l": "D-erythrose 4-phosphate + H2O + phosphoenolpyruvate <=> 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097110", "l": "scaffold protein binding", "d": ["Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64599", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.41", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26008", "l": "beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP => di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0031634", "l": "replication fork barrier binding", "d": ["Binding to replication fork barriers, sites that inhibit the progress of replication forks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42110", "l": "H(+) + NADH + progesterone => (20S)-hydroxypregn-4-en-3-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25584", "l": "alpha-L-rhamnose = beta-L-rhamnose", "d": [], "t": []}, {"i": "EC:5.1.3.32", "l": "\"L-rhamnose mutarotase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12038", "l": "3-(imidazol-5-yl)pyruvate + H(+) + NADH => (S)-3-(imidazol-5-yl)lactate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665702", "l": "ERBB2 TMD/JMD mutants bind TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867613", "l": "PICALM binds R-SNAREs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15535", "l": "3-sulfopyruvate + H(+) + NADH => (2R)-3-sulfolactate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45796", "l": "(3R)-3-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37502", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170986", "l": "Ral-GDS binds to Ras-GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977629", "l": "Displacement of C2a/Bb by CR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68111", "l": "L-glucitol + NAD(+) <=> H(+) + keto-L-fructose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78790", "l": "apigenin + UDP-alpha-D-glucose <=> H(+) + isovitexin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10122", "l": "inosine in double-stranded RNA + NH4(+) => adenosine in double-stranded RNA + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49305", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428231", "l": "ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033441", "l": "AAU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41222", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32261", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde => beta-D-fructose 1-phosphate + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804402", "l": "TP53 binds POU4F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12928", "l": "D-erythrose 4-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62683", "l": "naphtopyrone YWA1 <=> H(+) + H2O + norrubrofusarin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74490", "l": "anthranilate + 2 ATP + O-methyl-L-tyrosine + S-adenosyl-L-methionine <=> (-)-4'-methoxycyclopeptine + 2 AMP + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38387", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015130", "l": "mevalonate transmembrane transporter activity", "d": ["Enables the transfer of mevalonate from one side of a membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102025", "l": "ABC-type thiosulfate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77141", "l": "1D-myo-inositol 2-phosphate + phosphate => 1D-myo-inositol 2,3-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.15", "l": "\"carboxypeptidase A2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624272", "l": "MMPs cleave HB-EGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51766", "l": "4-prenylphlorisovalerophenone + diphosphate => dimethylallyl diphosphate + phlorisovalerophenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856945", "l": "PP2A methylation by LCMT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16423", "l": "a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72193", "l": "(16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59125", "l": "(S)-2,3-diaminopropanoate + ATP + citrate => 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114558", "l": "Thrombin-activated PARs activate Gq (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15199", "l": "an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11631", "l": "a 2-oxocarboxylate + H(+) <=> an aldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862380", "l": "HSD17B13 binds lipid droplets (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45183", "l": "2 (E)-4-coumaroyl-CoA + spermidine <=> 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49969", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.275", "l": "\"gibberellin A9 O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27734", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate", "d": [], "t": []}, {"i": "EC:3.5.1.n3", "l": "\"4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10872", "l": "H2O + N-acyl-L-aspartate = a carboxylate + L-aspartate", "d": [], "t": []}, {"i": "EC:3.5.1.15", "l": "\"aspartoacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77339", "l": "(2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25936", "l": "8-methylquinoline + A + H2O = 8-methylquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33622", "l": "ATP + CoA + tetradecanoate <=> AMP + diphosphate + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689111", "l": "PARK2 autoubiquitinates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69804", "l": "ATP + benzoate + H(+) => benzoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74690", "l": "a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + A + a macrocyclic archaeaol phospholipid + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353313", "l": "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047389", "l": "glycerophosphocholine phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28421", "l": "(R)-carnitine + 4-(trimethylamino)butanoyl-CoA <=> (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70967", "l": "IDH3 complex decarboxylates isocitrate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0043797", "l": "glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-517444", "l": "TAT aminates HPP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28737", "l": "H(+)(out) + spermidine(in) => H(+)(in) + spermidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429157", "l": "ABCC4 accumulation of dense granule contents (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60334", "l": "H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77077", "l": "Capping complex formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43609", "l": "agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O => 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71409", "l": "2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68017", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H2O => (2E,6E,10E)-geranylgeraniol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67889", "l": "3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine => 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47476", "l": "(3E)-tetradecenoyl-CoA = (2E)-tetradecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22227", "l": "3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA <=> 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817942", "l": "Expression of LEUTX in the embryo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683792", "l": "p-T68-CHEK2 autophosphorylates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44351", "l": "ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide B + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.57", "l": "\"long-chain fatty acid adenylase/transferase FadD23\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019977", "l": "interleukin-21 binding", "d": ["Binding to interleukin-21."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093329", "l": "EFNBs bind SDCBP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928625", "l": "PAKs autophosphorylate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31167", "l": "(3S)-hydroxytetradecanoyl-CoA + NAD(+) = 3-oxotetradecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13995", "l": "2-methyl-3-oxopropanoate + L-glutamate => (S)-3-amino-2-methylpropanoate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167084", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39105", "l": "ADP + H(+) + phosphate + sitosterol(out) => ATP + H2O + sitosterol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48622", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22536", "l": "(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine = (S)-tetrahydropalmatine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.89", "l": "\"tetrahydrocolumbamine 2-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9838093", "l": "LONP1 binds mitochondrial matrix proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60340", "l": "N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734687", "l": "ORC6 is phosphorylated on T195 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72882", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate <=> NH4(+) + phosphonoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202692", "l": "PIP3 binds to RhoA and activates it (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021364", "l": "ELF3 binds NOTCH3 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55619", "l": "a carotenoid psi-end group <=> a carotenoid epsilon-end group", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54882", "l": "(3R)-3-isopropenyl-6-oxoheptanoate + H(+) => (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46780", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.46", "l": "\"sn-1 linoleoyl-lipid 6-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50096", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60398", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31886", "l": "(S)-2,3-epoxysqualene <=> delta-amyrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40168", "l": "hexadecanoyl-CoA + O2 => (2E)-hexadecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701147", "l": "TRPV1 binds TRPV1 blockers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592387", "l": "Fibulin binds elastic fibres (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70246", "l": "an N-acylsphing-4-enine + UDP-alpha-D-xylose <=> a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20460", "l": "D-arabinose + NAD(+) <=> D-arabinono-1,4-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62892", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA = 6 CO2 + 7 CoA + 2 H2O + nor-toralactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004962", "l": "endothelin receptor activity", "d": ["Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71882", "l": "2'-deoxyguanosine + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27528", "l": "(2E,6E)-farnesol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070742", "l": "C2H2 zinc finger domain binding", "d": ["Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035143", "l": "NR1H2,3 binds the APOC4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3782637", "l": "HDAC8 deacetylates histones (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0030971", "l": "receptor tyrosine kinase binding", "d": ["Binding to a receptor that possesses protein tyrosine kinase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0008320", "l": "protein transmembrane transporter activity", "d": ["Enables the transfer of a protein from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247839", "l": "Retromer associates with WLS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035642", "l": "histone H3R17 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to the arginine residue at position 17 of histone H3."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16081", "l": "(2R)-S-methyl-3-phospho-1-thioglycerate + H2O = (2R)-S-methyl-1-thioglycerate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.14", "l": "\"methylphosphothioglycerate phosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022073", "l": "Procollagen triple helix formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624272", "l": "MMPs cleave HB-EGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218832", "l": "CDC42:GTP binds PAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70634", "l": "H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72605", "l": "(E)-sinapoyl-AMP + diphosphate => (E)-sinapate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12136", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) = a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237160", "l": "MTA is cleaved and phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213246", "l": "Disassociation of CLIP from MHC II (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32306", "l": "(2R)-homocitrate <=> (2R,3S)-homoisocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18728", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA <=> acetyl-CoA + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964278", "l": "G protein alpha (s):GTP binds SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28795", "l": "2 a Fe(II)-siderophore + H(+) + NADP(+) = 2 a Fe(III)-siderophore + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47857", "l": "a ganglioside GD1a (d18:1(4E)) + H2O => a ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58495", "l": "ATP + Fe(III)-enterobactin(out) + H2O <=> ADP + Fe(III)-enterobactin(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30073", "l": "acetate + butanoyl-CoA => acetyl-CoA + butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.13", "l": "\"L-methionine (S)-S-oxide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18146", "l": "ATP + beta-D-fructose => ADP + beta-D-fructose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-443831", "l": "14-3-3-zeta binds Raf1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5159250", "l": "ATF7IP binds SETDB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450088", "l": "GLUT1 tetramer binds 4xATP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.3", "l": "\"mannuronate-specific alginate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39139", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O = (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76858", "l": "2-aminopentane + H2O + NAD(+) <=> H(+) + NADH + NH4(+) + pentan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047246", "l": "luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: luteolin 7-O-beta-D-glucosiduronate + UDP-alpha-D-glucuronate = H+ + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029454", "l": "Autophosphorylation of PAK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2465924", "l": "OPN1LW binds 11cRAL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50990", "l": "prostaglandin F2alpha(in) => prostaglandin F2alpha(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42226", "l": "AH2 + androst-4-ene-3,17-dione => A + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77444", "l": "a ganglioside GT3 + UDP-N-acetyl-alpha-D-galactosamine => a ganglioside GT2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961952", "l": "CDT1 gene expression is stimulated by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018559", "l": "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009703", "l": "nitrate reductase (NADH) activity", "d": ["Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444661", "l": "HCAR2 binds HCAR2 ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804099", "l": "HMGB1 binds LTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78749", "l": "a 4-deoxy-alpha-L-threo-hex-4-enopyranuronoside + L-rhamnopyranose => an alpha-L-rhamnosyl-(1->4)-beta-D-glucuronide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44370", "l": "Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide => Cr(6+) + 2 NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69971", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66872", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5604929", "l": "Activated protein C binds Protein S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64824", "l": "1-naphthaleneacetamide + H2O = 1-naphthaleneacetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68651", "l": "2 L-cysteine <=> H(+) + hydrogen sulfide + L-lanthionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247497", "l": "ERBB3 binds neuregulins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635843", "l": "GLI translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55648", "l": "2-oxoglutarate + O2 + validoxylamine A = CO2 + H(+) + succinate + validoxylamine B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46474", "l": "4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47606", "l": "a ganglioside GP1calpha (d18:1(4E)) + CMP + H(+) => a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43443", "l": "hexadecanoate + sphinganine <=> H2O + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71462", "l": "H2O + substance P <=> L-Leu-L-Met-NH2 + substance P(1-9)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31871", "l": "(S)-2,3-epoxysqualene = alpha-seco-amyrin", "d": [], "t": []}, {"i": "EC:5.4.99.52", "l": "\"alpha-seco-amyrin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72659", "l": "NADPH + O2 + quinolin-8-ol = 8-hydroxyquinoline N-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865320", "l": "CBFB binds RUNX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72116", "l": "glycine betaine(out) + Na(+)(out) => glycine betaine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35212", "l": "dIDP + H2O => dIMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198756", "l": "ERK1/2 phosphorylates MSK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605797", "l": "SMPD1 hydrolyzes SPHM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004878", "l": "complement component C5a receptor activity", "d": ["Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41515", "l": "L-ornithine + NADH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60879", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12991", "l": "a dolichyl phosphate + D-mannose + H(+) => a dolichyl beta-D-mannosyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9823910", "l": "Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646685", "l": "Aggresome dissociates from dynein and microtubule (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445084", "l": "Phosphorylation of L1 by SRC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73255", "l": "(2S)-sakuranetin + S-adenosyl-L-methionine = (2S)-naringenin 4',7-dimethyl ether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18375", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50533", "l": "acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013023", "l": "RHOB GEFs activate RHOB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55538", "l": "a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654224", "l": "Activated FGFR3 binds PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18212", "l": "(2E)-geranyl diphosphate <=> (2S,4R)-bornyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3139027", "l": "Maturation of HIV Virion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25940", "l": "8-chloroquinoline + A + H2O = 8-chloroquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60234", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20956", "l": "2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA", "d": [], "t": []}, {"i": "EC:6.2.1.30", "l": "\"phenylacetate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858475", "l": "ppDVL recruits RAC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098851", "l": "double-stranded miRNA binding", "d": ["Binding to double-stranded miRNA. double-stranded miRNA is formed by processing of pre-miRNA stem-loop structures."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.188221489317044", "identifiers": [{"i": "GO:0140828", "l": "metal cation:monoatomic cation antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(in) = solute(in) + Na+(out)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.136", "l": "\"2-acylphloroglucinol 4-prenyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372448", "l": "SLC25A12,13 exchange L-Glu and L-Asp (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60315", "l": "L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77047", "l": "4-phenylbutan-2-amine + H2O + NAD(+) = 4-phenylbutan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180732", "l": "Translocation of Rev:importin-beta:B23 to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54213", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 => 2-(prostaglandin G2)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15137", "l": "galactitol 1-phosphate + NAD(+) = H(+) + keto-L-tagatose 6-phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42942", "l": "5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in tRNA precursor + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45104", "l": "6-demethylmitomycin A + S-adenosyl-L-methionine = mitomycin A + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62991", "l": "dodecanamide + H2O <=> dodecanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14575", "l": "5-dehydro-4-deoxy-D-glucarate + H2O => D-glucarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78248", "l": "D-tryptophan + H2O + O2 => H2O2 + indole-3-pyruvate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54793", "l": "L-histidyl-[protein] + N(7)-methyl-GTP => diphosphate + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66039", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67033", "l": "4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] => 4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950766", "l": "IL27RA dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28749", "l": "NH4(+)(out) => NH4(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30648", "l": "1D-myo-inositol 3-phosphate + CTP + H(+) => CDP-1L-myo-inositol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295622", "l": "SPRY2 binds CBL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67562", "l": "adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate => 3'-phosphoadenylyl sulfate + taurocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53986", "l": "(11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37563", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1878002", "l": "XYLTs transfer Xyl to core protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20128", "l": "H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74622", "l": "CMP(in) + UMP(out) <=> CMP(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16513", "l": "(S)-lactate + O2 = acetate + CO2 + H2O", "d": [], "t": []}, {"i": "EC:1.13.12.4", "l": "\"lactate 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784735", "l": "PCSK9:LDLR bind to Clathrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849646", "l": "SPINK5(490-624) binds KLK5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50160", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805399", "l": "TAF1 phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40463", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614271", "l": "Autocleavage of ADGRG6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15211", "l": "2-hydroxy-3-oxosuccinate + H(+) + NADH => (2R,3R)-tartrate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052933", "l": "alcohol dehydrogenase (cytochrome c(L)) activity", "d": ["Catalysis of the reaction: 2 [Fe(III)cytochrome cL] + a primary alcohol = 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44756", "l": "2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32978", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618394", "l": "ARL4C gene transcription regulated by NR1H2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69676", "l": "eriodictyol-7-O-beta-D-glucoside + H2O => (S)-eriodictyol + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.2", "l": "\"dihydroorotate dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2314678", "l": "ASA- acetylates PTGS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373711", "l": "DCC interaction with Netrin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592229", "l": "TFAM translocates from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77611", "l": "2 3-tetradecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-tetradecanoyl-sn-glycero-1-phospho-(3'-tetradecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73340", "l": "ATP + beta-alanine + H(+) => beta-alanyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55872", "l": "anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH", "d": [], "t": []}, {"i": "EC:1.7.1.17", "l": "\"FMN-dependent NADH-azoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-383190", "l": "HCO3- transport through ion channel (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984689", "l": "Kinesin-7 is a dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23681", "l": "a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015553", "l": "xanthosine transmembrane transporter activity", "d": ["Enables the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16245", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.121", "l": "\"1-alkenylglycerophosphoethanolamine O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022849", "l": "glutamate-gated calcium ion channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944262", "l": "Association of procollagen type X (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62084", "l": "ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0035939", "l": "microsatellite binding", "d": ["Binding to a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050298", "l": "stizolobinate synthase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73668", "l": "(E,E)-piperoyl-CoA + 2-methylpropan-1-amine => (E,E)-piperlonguminine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30858", "l": "dammarenediol-II <=> (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46868", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) = a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73520", "l": "dUTP(out) + UTP(in) => dUTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52285", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68996", "l": "2-oxoglutarate + gibberellin A9 + O2 = CO2 + gibberellin A4 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20631", "l": "L-seryl-[protein] + phosphate => H2O + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031769", "l": "glucagon receptor binding", "d": ["Binding to a glucagon receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67100", "l": "fumigatonoid B = fumigatonoid C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53738", "l": "a halide anion + catechol + CO2 + NAD(+) => a 2-halobenzoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46403", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16167", "l": "CO2 + H2O + indole-3-acetamide => L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34332", "l": "H(+) + indole-3-pyruvate + NADPH + O2 => (indol-3-yl)acetate + CO2 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863727", "l": "STON2 is neddylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32709", "l": "(2R,4S)-bornyl diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848818", "l": "PTK6 phosphorylates CBL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374298", "l": "Opioid receptors bind opioid peptides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634228", "l": "TRAF1 is cleaved by caspases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0042132", "l": "fructose 1,6-bisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8981892", "l": "Active G alpha (z) binds RGS proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46279", "l": "(S)-malate + H(+) <=> (S)-lactate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209973", "l": "Tyrosine is diiodinated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706837", "l": "AR binds AR antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9861734", "l": "PDH E1 decarboxylates PYR, transferring acetyl to DLAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28417", "l": "gamma-L-glutamylputrescine + H2O + O2 <=> 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66829", "l": "2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682967", "l": "WHSC1 binds DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75597", "l": "11-hydroxy-12,13-epoxy-(9Z)-octadecenoate => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56542", "l": "1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29357", "l": "2'-deoxyuridine + phosphate => dUMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40372", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP => 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21199", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine <=> L-methionine + tetrahydropteroyltri-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42299", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] <=> a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103102", "l": "UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 8-methylthiooctylhydroximate = H+ + 7-methylthioheptyldesulfoglucosinolate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77970", "l": "all-trans-hexaprenyl diphosphate <=> diphosphate + macrophomene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483089", "l": "PE is converted to PS by PTDSS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982810", "l": "JAK2 phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71047", "l": "glycine(in) + L-phenylalanine(out) = glycine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75316", "l": "chloride(out) + D-serine(out) + 2 Na(+)(out) => chloride(in) + D-serine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9007447", "l": "E2F6 forms the PRC1L4 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35094", "l": "anthranilate + 2 ATP + L-phenylalanine + S-adenosyl-L-methionine <=> 2 AMP + cyclopeptine + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32085", "l": "CMP-pseudaminate + diphosphate => CTP + pseudaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2314686", "l": "ASA- acetylates PTGS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9845192", "l": "Asvasiran binds N mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937177", "l": "AHR:TCDD binds ARNT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70467", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2 = a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424484", "l": "Phosphorylation of BTK by p-SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61259", "l": "H2O + L-cysteine + O2 <=> 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784189", "l": "JAKs bind LIFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388503", "l": "Oxytocin receptor bind oxytocin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77008", "l": "(2S)-5,5-dimethylpiperidine-2-carboxylate + 10-hydroxy-pre-flavunoidine + ATP => AMP + diphosphate + flavunoidine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22470", "l": "2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate => GTP + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434130", "l": "IRAK4 binds to activated TLR5 or 15. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0000049", "l": "tRNA binding", "d": ["Binding to a transfer RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32240", "l": "gamma-carotene => all-trans-beta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52099", "l": "9-octadecanoyloxy-octadecanoate + H2O <=> 9-hydroxy-octadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421482", "l": "hydroxymethylbilane => uroporphyrinogen III + H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9853512", "l": "DLST transfers succinyl to CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14236", "l": "a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33034", "l": "H(+) + keto-D-fructose + NADH <=> D-sorbitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10572", "l": "vinylacetyl-CoA = (2E)-butenoyl-CoA", "d": [], "t": []}, {"i": "EC:5.3.3.3", "l": "\"vinylacetyl-CoA Delta-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38413", "l": "(9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63662", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+) => (8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828196", "l": "TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23410", "l": "2 H(+) + NADPH + precorrin-6A => NADP(+) + precorrin-6B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685608", "l": "CLEC2B binds KLRF1 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45329", "l": "7,8-dihydroneopterin => 7,8-dihydromonapterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9839377", "l": "TGFB1,TGFB2 bind TGFBR3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395768", "l": "LPL hydrolyses TGs from mature CMs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40835", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O = 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68839", "l": "(2Z,6E)-farnesyl diphosphate <=> (6R,7S)-himachala-9,11-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848930", "l": "PTK6 translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-976768", "l": "Factor H binds to C3b (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821395", "l": "PAXIP1 binds PAGR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66170", "l": "[protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate => [protein]-with a C-terminal TM segment(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65288", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67051", "l": "AH2 + chermesin D + O2 <=> A + asnovolin I + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19095", "l": "12,18-didecarboxysiroheme + 2 CO2 => 2 H(+) + siroheme", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77035", "l": "(2S)-heptan-2-amine + H2O + NAD(+) = H(+) + heptan-2-one + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008758", "l": "UDP-2,3-diacylglucosamine hydrolase activity", "d": ["Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772430", "l": "CTNNBIP1 binds beta-catenin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70241", "l": "PCK1 phosphorylates OA to yield PEP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54971", "l": "hexadecanoyl phosphate + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964311", "l": "G alpha (i):GTP binds SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450027", "l": "Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354077", "l": "Integrin alphaIIb beta3 activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75572", "l": "acetyl-CoA + cyathin A3 => 11-O-acetylcyathin A3 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.-", "l": "\"With a disulfide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13883", "l": "a carboxylate + a quinol + H(+) => a quinone + an aldehyde + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433456", "l": "Recruitment of STATs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851933", "l": "MET phosphorylates GAB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0050253", "l": "retinyl-palmitate esterase activity", "d": ["Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067659", "l": "Assembly of hexameric IL-6 receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707659", "l": "Hemes:LY96 activates TLR4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9858589", "l": "DLD dimer dehydrogenates dihydrolipoyl (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33263", "l": "L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.40", "l": "\"phenylalanine N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63668", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11603", "l": "ATP + CMP <=> ADP + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0018835", "l": "carbon phosphorus lyase activity", "d": ["Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate)."], "t": []}, {"i": "EC:4.7.1.-", "l": "\"Carbon-phosphorus lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75458", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11174", "l": "(6S)-5,6,7,8-tetrahydrofolate + L-methionine => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9866253", "l": "apo-UQCRFS1 binds LYRM7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40846", "l": "FAD + H(+) + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23661", "l": "4-imidazolone-5-propanoate + H2O => N-formimidoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814831", "l": "TBC1D20 binds RAB1:GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31538", "l": "2-oxoglutarate + L-arginine + O2 <=> CO2 + guanidine + L-glutamate 5-semialdehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16204", "l": "4-amino-4-deoxychorismate <=> 4-aminobenzoate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20251", "l": "D-alanine => L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40439", "l": "6-sulfo-beta-D-quinovose = 6-deoxy-6-sulfo-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32427", "l": "(1R,4S)-isodihydrocarvone + A = (S)-carvone + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55511", "l": "cucurbitadienol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxocucurbitadienol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10610", "l": "(E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698174", "l": "FLT3 mutants recruit PIK3CA through PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847537", "l": "RAB43:GTP binds USP8NL (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56981", "l": "4-hydroxybenzyl alcohol + 2 oxidized [azurin] => 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62771", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668904", "l": "Formation of the CTF18 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164522", "l": "Terminal (3' end) cleavage of viral DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41997", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose => a globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35376", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A(in) + ATP + H2O => (beta-L-Ara4N)2-(Kdo)2-lipid A(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354173", "l": "Activation of Rap1 by cytosolic GEFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909732", "l": "Phosphorylation of STAT2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13479", "l": "H(+) + indole-3-pyruvate + NADPH + NH4(+) => H2O + L-tryptophan + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19105", "l": "4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.19", "l": "\"aminobutyraldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64839", "l": "2-phenylethanol + acetyl-CoA <=> CoA + phenethyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617452", "l": "Retinoic acid activates HOXB1 chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177479", "l": "Axonal transport of NGF:Trk complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77855", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-phenylalanine + O2 = 2-dehydro-D-glucose + H2O2 + L-phenylalanine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29655", "l": "L-cysteine(in) = L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18462", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093342", "l": "SDC2 multimerises (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446364", "l": "Migfilin interacts with VASP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48527", "l": "a ganglioside GP1c + H2O <=> a ganglioside GQ1c + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44439", "l": "a 1,2-diacylglycerol + a 1-acylglycerol <=> a triacylglycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788867", "l": "FN3K phosphorylates ketosamines (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78539", "l": "2 H2O + 4 nitric oxide + O2 = 4 H(+) + 4 nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66273", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43695", "l": "ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] <=> AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956639", "l": "RUNX1 binds YAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174058", "l": "Degradation of multiubiquitinated Cdh1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56681", "l": "beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9859172", "l": "DLD dimer dehydrogenates dihydrolipoyl (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858721", "l": "MITF-M dimer binds the TERT gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701548", "l": "PRDM1 gene expression downstream of ALK signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32554", "l": "(2E)-geranyl diphosphate + H2O <=> (S)-alpha-terpineol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47561", "l": "a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GM1b (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64612", "l": "ATP + L-glutamate + tRNA(Gln) = AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985293", "l": "NKX3-2 binds RUNX2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951644", "l": "Release of mature NEDD8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49539", "l": "2-amino-2-deoxy-D-gluconate <=> (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72519", "l": "2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate = 6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60197", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445448", "l": "HHIP binds Hedgehog (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59656", "l": "D-cellotriose + O2 = D-cellotriono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047167", "l": "1-alkyl-2-acetylglycerol O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635892", "l": "ATF4 binds the ATF3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48234", "l": "CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde => acetyl-CoA + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-500717", "l": "Activation of GRIK3 homomer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694409", "l": "Nucleotide exchange on RAB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13537", "l": "(2R)-3-phosphoglycerate + GDP-alpha-D-mannose = 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.217", "l": "\"mannosyl-3-phosphoglycerate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46767", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159773", "l": "Furin cleaves pro-protein S to protein S (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43531", "l": "L-serine + NAD(+) <=> 2-aminomalonate semialdehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16351", "l": "A + chlorite + H2O => AH2 + chlorate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23578", "l": "berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27587", "l": "L-tryptophan + pyruvate => indole-3-pyruvate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34662", "l": "C30 botryococcene + S-adenosyl-L-methionine <=> 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46536", "l": "(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11808", "l": "bergaptol + S-adenosyl-L-methionine = bergapten + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791235", "l": "GADD45A binds AURKA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76784", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] => 1,9-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72700", "l": "acrylate + H(+) + NADH => NAD(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828718", "l": "NS2 (1B) mRNA is translated into protein NS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165195", "l": "GTP loading by Rheb (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451418", "l": "Pellino ubiquitinates IRAK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32926", "l": "H2O + sn-glycero-3-phospho-(1'-sn-glycerol) <=> glycerol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018502", "l": "2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity", "d": ["Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17867", "l": "6,7-dihydropteridine + H(+) + NADPH => 5,6,7,8-tetrahydropteridine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046789", "l": "host cell surface receptor binding", "d": ["Binding to a receptor on the host cell surface."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37138", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate <=> 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609921", "l": "SGTA binds Tail-anchored protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46273", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65625", "l": "hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine => CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14818", "l": "4-maleylacetoacetate => 4-fumarylacetoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177501", "l": "Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51665", "l": "D-5-phenylhydantoin + H2O => H(+) + N-carbamoyl-D-phenylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802932", "l": "Dissociation of BRAF/RAF fusion complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70510", "l": "LDH tetramer oxidises LACT to PYR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56310", "l": "1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14742", "l": "4-methylene-L-glutamine + H2O => 4-methylene-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57675", "l": "(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] <=> 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73227", "l": "(3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19443", "l": "3-hydroxy-cis,cis-muconate + 2 H(+) => benzene-1,2,4-triol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613476", "l": "EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50178", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59610", "l": "beta-alanine + L-lysine => beta-alanyl-L-lysine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17481", "l": "2 cob(I)alamin + H(+) + NAD(+) = 2 cob(II)alamin + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26552", "l": "(S)-piperazine-2-carboxylate + NH4(+) => (S)-piperazine-2-carboxamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454916", "l": "The ABCC family mediates organic anion transport (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63019", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21427", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55780", "l": "all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate = all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57661", "l": "(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042975", "l": "peroxisome proliferator activated receptor binding", "d": ["Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35270", "l": "ethanol(in) <=> ethanol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38365", "l": "glycerol + H(+) + octadecanoate => 1-octadecanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0002094", "l": "polyprenyltransferase activity", "d": ["Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40023", "l": "9alpha-copalyl diphosphate + H2O = diphosphate + syn-copalol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65438", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate => a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266303", "l": "Spherical HDL binds C and E apolipoproteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0042009", "l": "interleukin-15 binding", "d": ["Binding to interleukin-15."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19838", "l": "D-sorbitol 6-phosphate + NAD(+) => beta-D-fructose 6-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20302", "l": "ATP + L-arginine + tRNA(Arg) => AMP + diphosphate + L-arginyl-tRNA(Arg)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396113", "l": "Dystroglycan binds AGRN and HSPG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102443", "l": "L-2-hydroxycarboxylate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD(1-) + a (2S)-2-hydroxycarboxylate = NADH(2-) + H+ + a 2-oxo carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855648", "l": "SALM3 binds LAR-RPTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32199", "l": "androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.30", "l": "\"3-ketosteroid 9alpha-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23083", "l": "L-rhamnonate <=> 2-dehydro-3-deoxy-L-rhamnonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58880", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27559", "l": "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + 3 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.83", "l": "\"hexaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61192", "l": "(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] = CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42861", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H2O => 1,2-dioctanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046099", "l": "Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358919", "l": "MSH2:MSH3 exchanges ADP for ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202703", "l": "CD47 binds SIRP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022871", "l": "protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48897", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a => 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008677", "l": "2-dehydropantoate 2-reductase activity", "d": ["Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944229", "l": "Association of procollagen type IX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41704", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40545", "l": "H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380201", "l": "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35640", "l": "(4S)-4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102603", "l": "12-demethyl-elloramycin C12a O-methyltransferase activity", "d": ["Catalysis of the reaction: 12-demethyl-elloramycin + S-adenosyl-L-methionine = elloramycin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75063", "l": "chloride(out) + 2 hydrogencarbonate(in) + Li(+)(in) = chloride(in) + 2 hydrogencarbonate(out) + Li(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210294", "l": "Interaction of PECAM-1 and SHP-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-921155", "l": "p-STAT5 dissociates from the receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42749", "l": "cytidine(967) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77068", "l": "H2O + NADP(+) + pentylamine => H(+) + NADPH + NH4(+) + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664285", "l": "IgG binds the surface of the amastigote form of Leishmania (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77310", "l": "N(omega),N('omega)-dimethyl-L-arginine + pyruvate <=> 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9796617", "l": "MIB2 binds CFLAR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28869", "l": "H(+)(out) + lactose(out) => H(+)(in) + lactose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103007", "l": "indole-3-acetate carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: indole-3-acetate + S-adenosyl-L-methionine = methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102807", "l": "cyanidin 3-O-glucoside 2''-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-O-beta-D-glucoside betaine = cyanidin 3-O-sophoroside + UDP + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416530", "l": "FFAR1:FFAR1 ligands activate Gq (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433451", "l": "JAK2 binds to p-KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9774195", "l": "ZC3H12A binds CDH19 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.34", "l": "\"monoprenyl isoflavone epoxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34606", "l": "15-methylhexadecasphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-15-methylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016608", "l": "growth hormone-releasing hormone activity", "d": ["The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59094", "l": "[(1->3)-alpha-D-glucosyl](n+1) + D-fructose => [(1->3)-alpha-D-glucosyl](n) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034940", "l": "5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity", "d": ["Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17903", "l": "H(+) + S-adenosyl-L-homocysteine + xanthotoxin => S-adenosyl-L-methionine + xanthotoxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839368", "l": "TGFBR3(1-783) binds to TGFB1,TGFB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693598", "l": "ATM phosphorylates NBN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10041", "l": "adenosine 3',5'-bisphosphate + H2O => AMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-555065", "l": "Formation of clathrin coated vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549322", "l": "OCT1 transports organic cations out of hepatic cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12908", "l": "alpha-D-mannose 1-phosphate + GDP + H(+) <=> GDP-alpha-D-mannose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873946", "l": "OTUD3 deubiquitinates PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670426", "l": "Disassociation and translocation of STATs to the nucleus downstream of KIT mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362522", "l": "ALDHs oxidise atRAL to atRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625424", "l": "The retrograde IFT train dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30195", "l": "15,9'-di-cis-phytofluene + plastoquinone-9 = 9,9',15-tri-cis-zeta-carotene + plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964287", "l": "G alpha (s):GTP:SRC dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9823816", "l": "OPTN binds CASP8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632671", "l": "CSNK1A1 binds SMO dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71603", "l": "2-oxoglutarate(out) + oxaloacetate(in) = 2-oxoglutarate(in) + oxaloacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031828", "l": "type 2C serotonin receptor binding", "d": ["Binding to a type 2C serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000034", "l": "adenine deaminase activity", "d": ["Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.674113164858127", "identifiers": [{"i": "GO:0008134", "l": "transcription factor binding", "d": ["Binding to a transcription factor, a protein required to initiate or regulate transcription."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76088", "l": "a dicarboxylate(in) + kynurenate(out) => a dicarboxylate(out) + kynurenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.72", "l": "\"xylan 1,3-beta-xylosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614591", "l": "Excess cysteine yields lanthionine and H2S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58180", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH = all-trans-lycopaoctaene + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28238", "l": "calycosin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50430", "l": "dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine => methanethiol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70202", "l": "dopaminechrome <=> 5,6-dihydroxyindole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29293", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate => (25S)-3-oxocholest-4-en-26-oate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13746", "l": "ascopyrone M => microthecin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22158", "l": "GMP + H(+) + phosphate => GDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34086", "l": "a (3R)-3-hydroxyacyl-CoA <=> a (3S)-3-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624951", "l": "TNPO1 binds KIF17 dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5631885", "l": "PRDX1 overoxidizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58628", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV = FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54202", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55926", "l": "albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => albendazole + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20866", "l": "beta-D-glucose 1-phosphate + D-glucose 6-phosphate => alpha,alpha-trehalose 6-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45437", "l": "H2O + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-hexadecanoylethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64619", "l": "(E)-coniferol + acetyl-CoA <=> (E)-coniferyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.764964831105814", "identifiers": [{"i": "GO:0015171", "l": "amino acid transmembrane transporter activity", "d": ["Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036431", "l": "dCMP kinase activity", "d": ["Catalysis of the reaction: ATP + dCMP = ADP + dCDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856465", "l": "MLPH/MYRIP bind GGC-RAB27A and MYO5A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687465", "l": "MRN complex binds RBBP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12976", "l": "AMP + ATP <=> 2 ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64693", "l": "isobutanol + NAD(+) => 2-methylpropanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11386", "l": "2-oxooctadecanoate + H(+) + NADH => (S)-2-hydroxyoctadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42292", "l": "a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.274", "l": "\"phosphate acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034826", "l": "1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700154", "l": "Active ALK binds SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034540", "l": "3-monobromobisphenol A reductive dehalogenase activity", "d": ["Catalysis of the reaction: 3-monobromobisphenol A + 2 H+ + 2 e- = bisphenol A + HBr."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0070546", "l": "L-phenylalanine aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9842669", "l": "Active LTK recruits GRB2:SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59979", "l": "2-phenylacetate + H(+) <=> CO2 + toluene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70466", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2 <=> a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17063", "l": "catechol + H2O + NADP(+) => H(+) + NADPH + O2 + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791228", "l": "45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.245", "l": "\"alpha,alpha-trehalose synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0042019", "l": "interleukin-23 binding", "d": ["Binding to interleukin-23."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694409", "l": "Nucleotide exchange on RAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34774", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) <=> a 3-oxosteroid + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.3", "l": "\"2-acetolactate mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11014", "l": "L-tryptophan + NH4(+) => H2O + L-tryptophanamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60190", "l": "2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59265", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31161", "l": "3-oxohexadecanoyl-CoA + H(+) + NADH => (3S)-hydroxyhexadecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835443", "l": "STAT1,STAT3 binds PKR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31270", "l": "6-hydroxyhexanoate + NADP(+) <=> 6-oxohexanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74715", "l": "Autophosphorylation of insulin receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25728", "l": "N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65379", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445714", "l": "Aquaporin-3 passively transports water out of cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41199", "l": "1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857305", "l": "Activated CEBPB and NFKB complex bind IL6 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30018", "l": "alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose <=> alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76655", "l": "3-methylbutanal + H2O + NAD(+) = 3-methylbutanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55240", "l": "1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78385", "l": "CoA + S-nitroso-L-cysteinyl-[SCAN] => L-cysteinyl-[SCAN] + S-nitroso-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62277", "l": "3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine => 6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66990", "l": "4-methylpentanoyl-CoA + AMP + diphosphate => 4-methylpentanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55612", "l": "an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O = 1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189069", "l": "sucrose + H2O => glucose + fructose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75519", "l": "FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2 = (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213248", "l": "Transport of antigen loaded MHC II molecules to surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62595", "l": "(S)-8-oxocitronellyl enol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59751", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44643", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP <=> a 2'-deoxyribonucleoside 5'-triphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42741", "l": "guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665411", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72928", "l": "O2 + proatranorin I + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52189", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-372542", "l": "Loading of dopamine into synaptic veiscles (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70114", "l": "6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18072", "l": "L-arginine <=> D-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022398", "l": "ACE:Zn2+ hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20245", "l": "ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.47", "l": "\"streptomycin 3''-adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16581", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2 = 2 Fe(III)-[cytochrome c] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.11.1.5", "l": "\"cytochrome-c peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32801", "l": "urea(out) => urea(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68225", "l": "2-oxoglutarate + H(+) + O2 + prekainate => CO2 + H2O + kainate lactone + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52903", "l": "3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide <=> 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74783", "l": "tyramine(in) = tyramine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042951", "l": "arbutin transmembrane transporter activity", "d": ["Enables the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19425", "l": "H(+) + imidazole-4-acetate + NADH + O2 = 5-hydroxyimidazole-4-acetate + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.5", "l": "\"imidazoleacetate 4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58581", "l": "dihydroprecondylocarpine acetate => acetate + catharanthine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5195402", "l": "CDK1 phosphorylates LPIN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0032135", "l": "DNA insertion or deletion binding", "d": ["Binding to a double-stranded DNA region containing an insertion or a deletion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77456", "l": "formylthiophene + hydrogen cyanide => (2R)-2-hydroxy-2-(thiophen-2-yl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404144", "l": "Parenchymal atROL translocates to HSCs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29035", "l": "ATP + H2O + L-glutamate(out) = ADP + H(+) + L-glutamate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672817", "l": "Active MTORC1 binds the ULK1 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43778", "l": "an N-(acyl)-sphingosylphosphocholine(out) => an N-(acyl)-sphingosylphosphocholine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030165", "l": "PDZ domain binding", "d": ["Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19030", "l": "3 H(+) + H2O + urea-1-carboxylate => 2 CO2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53339", "l": "5,6-dihydrouridine(20) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59362", "l": "beta-alanine + L-histidine => carnosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003963", "l": "RNA-3'-phosphate cyclase activity", "d": ["Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952371", "l": "MDM2 binds RUNX3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380574", "l": "Dopamine synaptic vesicle docking and priming (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51095", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446391", "l": "Formation of the PINCH-ILK-parvin complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210274", "l": "SIRP beta binds TYROBP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420121", "l": "SFKs phosphorylate PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034017", "l": "trans-2-decenoyl-acyl-carrier-protein isomerase activity", "d": ["Catalysis of the reaction: trans-dec-2-enoyl-[acyl-carrier protein] = cis-dec-3-enoyl-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12203", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 <=> CO2 + mugineate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828726", "l": "P mRNA is translated into protein P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797090", "l": "CCNK binds CDK12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41052", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950740", "l": "CANX dissociates from IL12A:EBI3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39618", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA <=> (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49928", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419490", "l": "Binding of ATP to P2X receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75462", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013631", "l": "NICD3 binds RBPJ and MAML in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015568", "l": "L-idonate transmembrane transporter activity", "d": ["Enables the transfer of L-idonate from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41488", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38092", "l": "delta-tocotrienol + S-adenosyl-L-methionine => beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10782", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) + NADH => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451310", "l": "Activation of Edited Kainate receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018798", "l": "RHOV binds GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77548", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22012", "l": "precorrin-4 + S-adenosyl-L-methionine = precorrin-5 + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.133", "l": "\"precorrin-4 C(11)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785087", "l": "FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662621", "l": "MT1M binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79022", "l": "2-oxoglutarate + N(1)-methyladenosine(58) in tRNA + O2 <=> adenosine(58) in tRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950362", "l": "EBI3:CANX binds IL12A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74913", "l": "a (2E)-enoyl-[ACP] + AMP + diphosphate => a (2E)-enoyl fatty acid + ATP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31673", "l": "dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9843927", "l": "me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1HS,L1PA2,3 heterochromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58430", "l": "(E,E)-2,4-hexadienal + H(+) + NADPH => (E,E)-2,4-hexadien-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849882", "l": "SALMs 1-4 bind reticulon 3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69327", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate <=> 4-methylsulfanylbutyl isothionate + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52211", "l": "alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72133", "l": "agmatine(in) => agmatine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.9", "l": "\"isotuberculosinol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-517705", "l": "p-S318,221-HuR binds mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77095", "l": "5-S-cysteinyldopa + L-dopaquinone = 5-S-cysteinyldopaquinone + L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49202", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate => D-mannose 6-phosphate + H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44723", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75870", "l": "5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] <=> 5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48560", "l": "H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189062", "l": "lactose + H2O => D-glucose + D-galactose (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36425", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953339", "l": "DNPH1 hydrolyses dGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76055", "l": "norreticuline + S-adenosyl-L-methionine = H(+) + reticuline + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18777", "l": "an alkylmercury + H(+) = an alkane + Hg(2+)", "d": [], "t": []}, {"i": "EC:4.99.1.2", "l": "\"alkylmercury lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675473", "l": "SH2B binds JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15996", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 <=> 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72185", "l": "mRNA polyadenylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173705", "l": "C5b binds C6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163416", "l": "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617209", "l": "CEBPB gene transcription is enhanced by phospho-CREB1 and phospho-STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14240", "l": "10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74665", "l": "acetylcholine(out) => acetylcholine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74216", "l": "H2O + L-seryl-tRNA(Lys) => L-serine + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730872", "l": "Activation of Calcineurin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48981", "l": "3,4-dichlorocatechol + O2 => (2Z,4Z)-2,3-dichloromuconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71173", "l": "GSTZ1 isomerizes 4-MAA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.13", "l": "\"ornithine aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68207", "l": "1,2-dihexanoylglycerol + octadecanoyl-CoA <=> 1,2-dihexanoyl-3-octadecanoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43804", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76938", "l": "2-methylpropan-1-amine + H2O + NAD(+) <=> 2-methylpropanal + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53492", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)", "d": [], "t": []}, {"i": "EC:2.1.1.86", "l": "\"tetrahydromethanopterin S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45376", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78822", "l": "2-oxoglutarate + L-arginine <=> 5-guanidino-2-oxopentanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24875", "l": "D-serine + phosphate => H2O + O-phospho-D-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31832", "l": "(2E,6E)-farnesyl diphosphate => delta-guaiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12047", "l": "a triacylglycerol + H2O <=> a diacylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53800", "l": "lithocholoyl-CoA + ursodeoxycholate = lithocholate + ursodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32368", "l": "4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone => 4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40348", "l": "3-oxotetradecanedioyl-CoA + CoA => acetyl-CoA + dodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0140707", "l": "chromatin-nuclear membrane anchor activity", "d": ["Binding to chromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization, or to enable equal segregation of the nuclear membrane during mitosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20202", "l": "ATP + H2O + L-phenylalanine => AMP + D-phenylalanine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69104", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine = H2O + kynurenate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45564", "l": "2-epi-5-epi-valiolone = 5-epi-valiolone", "d": [], "t": []}, {"i": "EC:5.1.3.33", "l": "\"2-epi-5-epi-valiolone epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71922", "l": "3 Na(+)(out) + succinate(out) <=> 3 Na(+)(in) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22126", "l": "acetate + ajmaline + H(+) => 17-O-acetylajmaline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42199", "l": "(9Z)-heptadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-heptadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848250", "l": "ACBD6 binds LCFA-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22930", "l": "4-aminobutanoyl-CoA + acetate => 4-acetamidobutanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58914", "l": "ADP + H(+) + iron(III) dicitrate(in) + phosphate => ATP + H2O + iron(III) dicitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61209", "l": "8-nitro-cGMP + L-cysteinyl-[protein] => H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18656", "l": "barbiturate + H2O <=> 3-oxo-3-ureidopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102901", "l": "isopimaradienol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + isopimaradienol + NADPH + O2 = isopimaradiene-diol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47843", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine <=> (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77924", "l": "O2 + sym-homospermidine => H2O2 + N-(4-aminobutylpyrrolinium) ion + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14874", "l": "indole-3-ethanol + NAD(+) => H(+) + indole-3-acetaldehyde + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52920", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40746", "l": "(20S)-ginsenoside Rd + 2 H2O <=> (20S)-ginsenoside C-K + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353058", "l": "glucose 6-phosphate + H2O => glucose + phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10238", "l": "H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP => trans-2-coumarate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1369028", "l": "ABCAs mediate lipid efflux (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34227", "l": "5-nitrosalicylate + O2 = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite", "d": [], "t": []}, {"i": "EC:1.13.11.64", "l": "\"5-nitrosalicylate dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21556", "l": "[calmodulin]-L-lysine + S-adenosyl-L-methionine = [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.60", "l": "\"calmodulin-lysine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10010", "l": "[protein]-disulfide + an alcohol + H2O => [protein]-dithiol + a hydroperoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72013", "l": "glutathione(out) + urate(in) => glutathione(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.7", "l": "\"ribonuclease F\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157145", "l": "NOTCH3 binds DLL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664950", "l": "Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11224", "l": "ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.4", "l": "\"D-alanine--D-alanine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080115", "l": "myosin XI tail binding", "d": ["Binding to the tail region of a myosin XI heavy chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39011", "l": "a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58213", "l": "ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] => dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635853", "l": "Hh-dependent expression of GLI1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61217", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24863", "l": "H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP => pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034986", "l": "iron chaperone activity", "d": ["Directly binding to and delivering iron ions to a target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928602", "l": "NGEF binds EPHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55206", "l": "5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+) => 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35216", "l": "H2O + XDP => H(+) + phosphate + XMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373342", "l": "CX3CR1 binds CX3CL1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26058", "l": "GTP + H(+) + valienol 1-phosphate <=> diphosphate + GDP-valienol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76281", "l": "hypoxanthine(in) + Na(+)(in) => hypoxanthine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9853369", "l": "PLK1 phosphorylates FIRMM at S744 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61717", "l": "ATP + D-galactofuranose(out) + H2O => ADP + D-galactofuranose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70360", "l": "3-oxosphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34113", "l": "H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine => carboxyspermidine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74663", "l": "acetylcholine(in) = acetylcholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102039", "l": "NADH-dependent peroxiredoxin activity", "d": ["Catalysis of the reaction: a hydroperoxide + H+ + NADH = an alcohol + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676595", "l": "TRAFs bind RANK:RANKL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71613", "l": "(S)-malate(out) + malonate(in) => (S)-malate(in) + malonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265456", "l": "NPC1L1 binds ezetimibe (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416639", "l": "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55755", "l": "2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35301", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH => 3-hydroxyoctadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14244", "l": "3-amino-4-hydroxybenzaldehyde + acetyl-CoA <=> 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001223", "l": "transcription coactivator binding", "d": ["Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47745", "l": "demethylphylloquinone + H(+) + NADPH => demethylphylloquinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73333", "l": "cimicifugate E + CoA => (2R,3S)-piscidate + (E)-feruloyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2750187", "l": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49408", "l": "[(1->2)-beta-D-mannosyl](n) + phosphate = [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.340", "l": "\"1,2-beta-oligomannan phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836270", "l": "TFAP2A binds TFAP2C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661726", "l": "An unknown reductase reduces D-UBGN to STBN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12532", "l": "coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane", "d": [], "t": []}, {"i": "EC:2.8.4.1", "l": "\"coenzyme-B sulfoethylthiotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0031714", "l": "C5a anaphylatoxin chemotactic receptor binding", "d": ["Binding to a C5a anaphylatoxin chemotactic receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17040", "l": "indole-3-ethanol + NADP(+) <=> H(+) + indole-3-acetaldehyde + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12877", "l": "acetylacetone + O2 = acetate + H(+) + methylglyoxal", "d": [], "t": []}, {"i": "EC:1.13.11.50", "l": "\"acetylacetone-cleaving enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848023", "l": "Activated PTK6 binds STAP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46506", "l": "AMP + dodecanoyl-[ACP] + H(+) => dodecanoyl-AMP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31930", "l": "3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015471", "l": "nucleoside-specific channel forming porin activity", "d": ["Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18743", "l": "10-deacetylbaccatin III + CoA => 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61420", "l": "(S)-8-oxocitronellyl enol = cis-cis-nepetalactol", "d": [], "t": []}, {"i": "EC:5.5.1.35", "l": "\"(+)-cis,cis-nepetalactol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32960", "l": "H2O + L-isoleucine + NAD(+) => (S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732527", "l": "FFAR1 binds rosiglitazone (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19210", "l": "codeine + NADP(+) => codeinone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781953", "l": "YOD1 binds VCP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.107", "l": "\"sanguinarine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73371", "l": "(R)-pantothenate(out) + 2 Na(+)(out) = (R)-pantothenate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62438", "l": "2-dehydro-3-deoxy-L-arabinonate + H2O => L-lyxonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428609", "l": "Type I Na+-coupled phosphate co-transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18903", "l": "benzyl alcohol + CO2 + L-leucine => H(+) + H2O + N-benzyloxycarbonyl-L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0034326", "l": "butanoyltransferase activity", "d": ["Catalysis of the transfer of a butanoyl (CH3-[CH2]2-CO-) group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964482", "l": "DREAM complex binds the E2F1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34764", "l": "(S,S)-tartrate(out) + succinate(in) => (S,S)-tartrate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9769235", "l": "MAGED1 binds NPAS4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950504", "l": "IL27 binds CRLF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61941", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose => 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71152", "l": "4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one => (E)-caffeoylpyruvate + CO2 + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663122", "l": "p-BMAL1:p-CLOCK,NPAS2 binds NAMPT gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785762", "l": "IL13RA1 binds TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29605", "l": "4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40651", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168859", "l": "Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813749", "l": "ALDH1A1 oxidises GA to DGA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211951", "l": "CYP1B1 4-hydroxylates EST17b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46398", "l": "an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55481", "l": "ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17487", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481009", "l": "Exocytosis of platelet dense granule content (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56825", "l": "AH2 + cyclooctat-9-ene-5,7-diol + O2 => A + cyclooctatin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16698", "l": "A + H2O + quinaldate => AH2 + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928597", "l": "EPH:EFN dimers tetramerise (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987015", "l": "IL20 binds IL20RA:JAK1:IL20RB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57578", "l": "H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3787997", "l": "Laminin-332 binds collagen type VII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35003", "l": "L-fucose(in) = L-fucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22399", "l": "1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 <=> glycolaldehyde + guaiacol + H2O + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22485", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate => GMP + GTP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.674113164858127", "identifiers": [{"i": "GO:0070566", "l": "adenylyltransferase activity", "d": ["Catalysis of the transfer of an adenylyl group to an acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006873", "l": "IL21 receptor STAT binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46512", "l": "an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}, {"i": "EC:1.14.18.7", "l": "\"dihydroceramide fatty acyl 2-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67281", "l": "(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione => (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77793", "l": "an (E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amine + H(+) + H2O2 => an N-(1-deoxy-beta-D-fructopyranos-1-yl)amine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35236", "l": "H(+)(out) + tetracycline(in) => H(+)(in) + tetracycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46320", "l": "3beta-hydroxy-chol-5-ene-24-oyl-CoA + A = 3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17734", "l": "acetylenedicarboxylate + H(+) + H2O => CO2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.84", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14096", "l": "2-oxoglutarate + L-tryptophan <=> indole-3-pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015647", "l": "peptidoglycan transmembrane transporter activity", "d": ["Enables the transfer of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047060", "l": "(R)-pantolactone dehydrogenase (flavin) activity", "d": ["Catalysis of the reaction: (R)-pantolactone + A = 2-dehydropantolactone + AH(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12646", "l": "CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] => (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047814", "l": "D-arabinokinase activity", "d": ["Catalysis of the reaction: D-arabinose + ATP = D-arabinose 5-phosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13653", "l": "[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose = [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.10", "l": "\"levansucrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975118", "l": "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033723", "l": "fluoroacetaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24589", "l": "ATP + D-arabinose => ADP + D-arabinose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.28", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003952", "l": "NAD+ synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023196", "l": "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54475", "l": "1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12157", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) => 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70344", "l": "chloride + L-tyrosine + NADP(+) => 3-chloro-L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935864", "l": "miR-302b binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141197", "l": "4-hydroxy-3-methylbut-2-enyl-diphosphate synthase activity (flavodoxin)", "d": ["Catalysis of the reaction: (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H+ + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-481009", "l": "Exocytosis of platelet dense granule content (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37501", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55925", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] => albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9639286", "l": "RRAGC,D exchanges GTP for GDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57799", "l": "4-nitrotoluene + NADH + O2 <=> 4-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22096", "l": "phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)", "d": [], "t": []}, {"i": "EC:2.7.7.8", "l": "\"polyribonucleotide nucleotidyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664867", "l": "NBR1 binds MAP1LC3B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451311", "l": "Activation of Ca-permeable Kainate receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34105", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31607", "l": "rhodopin = all-trans-lycopene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45725", "l": "(E)-4-coumaroyl alcohol + NADP(+) => (E)-4-coumaraldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102193", "l": "protein-ribulosamine 3-kinase activity", "d": ["Catalysis of the reaction: ATP + a [protein]-N6-D-ribulosyl-L-lysine = ADP + a [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71714", "l": "H(+)(out) + L-tyrosylglycine(out) <=> H(+)(in) + L-tyrosylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50504", "l": "acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45543", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49925", "l": "(R)-carnitine(out) + O-acyl-(R)-carnitine(in) => (R)-carnitine(in) + O-acyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76996", "l": "H(+) + NADP(+) + 2 reduced [4Fe-4S]-[ferredoxin] => NADPH + 2 oxidized [4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75149", "l": "(-)-cyatha-3,12-diene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814096", "l": "ARL1:GTP binds SCOC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61701", "l": "glycyl-5'-AMP + holo-[peptidyl-carrier protein] => AMP + glycyl-[peptidyl-carrier protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.16024621048814", "identifiers": [{"i": "GO:0008374", "l": "O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60482", "l": "c-di-UMP + 2 diphosphate => 2 UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003998", "l": "acylphosphatase activity", "d": ["Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21755", "l": "all-trans-violaxanthin <=> all-trans-capsorubin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56012", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56550", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339535", "l": "CPTP transports C1P from plasma membrane to Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72551", "l": "glutarate(out) + urate(in) = glutarate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683755", "l": "Spike protein gets N-glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76008", "l": "(3R)-hydroxybutanoate pentamer + H2O => (3R)-hydroxybutanoate tetramer + (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9909159", "l": "HK1 phosphorylates Mannose to Man6P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0045703", "l": "ketoreductase activity", "d": ["Catalysis of the reduction of a ketone group to form the corresponding alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682009", "l": "ZCRB1 binds 5'UTR of SARS-CoV-1 genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669024", "l": "CD70 binds CD27 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71278", "l": "2 Na(+)(out) + taurolithocholate 3-sulfate(out) <=> 2 Na(+)(in) + taurolithocholate 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48021", "l": "a globoside Gb3Cer + H2O => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102352", "l": "phosphatidate kinase activity", "d": ["Catalysis of the reaction: ATP + a 1,2-diacyl-sn-glycerol 3-phosphate = ADP + a 1,2-diacyl-sn-glycerol 3-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730872", "l": "Activation of Calcineurin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30592", "l": "H2O + O2 + tyramine => (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0001864", "l": "pentraxin binding", "d": ["Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748996", "l": "GST dimers cleave AZA to 6MP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70081", "l": "CO2 + hydroxyclavatol + succinate => 2-oxoglutarate + clavatol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46907", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) <=> a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11716", "l": "a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29614", "l": "H2O + NADP(+) + nitrous oxide <=> H(+) + NADPH + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34806", "l": "2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> bisdemethoxycurcumin + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41304", "l": "H2O + N-dodecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + dodecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29029", "l": "2 H(+)(out) + L-glutamate(out) => 2 H(+)(in) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990147", "l": "talin binding", "d": ["Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54768", "l": "[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine = [LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52514", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+) => a quinone + trans-4-hydroxy-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592362", "l": "Activation of proMMP7 by MMP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781897", "l": "USP11 deubiquitinates NFKBIA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052897", "l": "N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: H2O + N(8)-acetylspermidine + O2 = 1,3-diaminopropane + 4-acetamidobutanal + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75490", "l": "dehydroepiandrosterone 3-sulfate(out) + n H(+)(out) <=> dehydroepiandrosterone 3-sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139941", "l": "Binding of IP3 to IP3 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.43", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77430", "l": "benzaldehyde + hydrogen cyanide <=> (S)-mandelonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71163", "l": "HPD dioxygenates HPP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67419", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30318", "l": "1,7-dimethylxanthine + H(+) + NADH + O2 <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28340", "l": "crotonobetainyl-CoA + H2O => (R)-carnitinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842651", "l": "Active LTK receptor phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9833973", "l": "ISGylation of PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048529", "l": "magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity", "d": ["Catalysis of the reaction: magnesium protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64596", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.370", "l": "\"inositol phosphorylceramide mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022065", "l": "DSPGs are secreted (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373734", "l": "Nephrin interacts with Podocin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49448", "l": "beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O = alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose", "d": [], "t": []}, {"i": "EC:3.2.1.197", "l": "\"beta-1,2-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66177", "l": "ATP + H2O + taurochenodeoxycholate 3-sulfate(in) => ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34327", "l": "4-nitrophenol + H(+) + NADPH + O2 = 1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": [], "t": []}, {"i": "EC:1.14.13.167", "l": "\"4-nitrophenol 4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805638", "l": "KAT6A acetylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51639", "l": "a quinone + H2O + selenite <=> a quinol + selenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29048", "l": "a menaquinone + 2 H(+)(in) + H2 => a menaquinol + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60006", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.-", "l": "\"Transferring other groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209193", "l": "Phosphorylated AP-1, Phospho JRA:Phospho KAY dissociates from CKA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3204311", "l": "AOX1 oxidises PXL to PDXate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.21", "l": "\"cholesterol 7-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70967", "l": "IDH3 complex decarboxylates isocitrate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045322", "l": "unmethylated CpG binding", "d": ["Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69489", "l": "O2 + tetradecan-1-ol => H2O2 + tetradecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34553", "l": "ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate => ATP + cob(II)yrinate c monoamide + H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39369", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+) => (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73577", "l": "CAD hexamer transforms L-Gln to CAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27544", "l": "4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde => methanol + N,N-dimethyl-4-nitrosoaniline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685838", "l": "CX3 complex binds D-loop structures (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033042", "l": "umami taste receptor activity", "d": ["Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52148", "l": "a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose = an aliphatic (Z)-desulfo-glucosinolate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43893", "l": "[sulfur carrier]-H + L-cysteine => [sulfur carrier]-SH + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11668", "l": "[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O = [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": [], "t": []}, {"i": "EC:2.7.9.4", "l": "\"alpha-glucan, water dikinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49205", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35617", "l": "H(+) + methylglyoxal + NADH => hydroxyacetone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29774", "l": "arsenate(in) + ATP + H2O <=> ADP + arsenate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51619", "l": "ATP + formate + H(+) <=> CO2 + dATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980044", "l": "NOTCH1 binds JAG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47935", "l": "(2S)-3-sulfolactaldehyde + H2O + NAD(+) <=> (2S)-3-sulfolactate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382061", "l": "Extracellular processing of novel PDGFs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055042", "l": "5-valerolactone hydrolase activity", "d": ["Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75833", "l": "5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003844", "l": "1,4-alpha-glucan branching enzyme activity", "d": ["Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69024", "l": "H(+) + N-hydroxy-L-aspartate + NADPH + O2 = H2O + N,N-dihydroxy-L-aspartate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141437", "l": "Formation of the MCC complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001179", "l": "RNA polymerase I general transcription initiation factor binding", "d": ["Binding to an RNA polymerase I transcription factor, a protein required to initiate or regulate transcription by RNA polymerase I."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18963", "l": "H2O + N(6)-(D-psicosyl)-L-lysyl-[protein] => D-allose + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17476", "l": "GTP + H2O <=> 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103085", "l": "2-(5'-methylthio)pentylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-7-methylthioheptanoate + acetyl-CoA + H2O = H+ + 2-(5'-methylthio)pentylmalate + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000341", "l": "RNA trimethylguanosine cap binding", "d": ["Binding to the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209143", "l": "Phosphorylation of AXN and APC by DCO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12856", "l": "(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose <=> dhurrin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851436", "l": "CFHR dimers bind C3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.19", "l": "\"tryptophan dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73199", "l": "maleate(in) + sulfate(out) = maleate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420233", "l": "VIP receptors bind VIP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38490", "l": "1-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56678", "l": "(E)-feruloyl-CoA + H(+) + NADPH => dihydroferuloyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299359", "l": "Activation of TALK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32541", "l": "(+)-car-3-ene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14706", "l": "2 CoA + NADP(+) => CoA-disulfide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0050187", "l": "phosphoamidase activity", "d": ["Catalysis of the reaction: N-phosphocreatine + H2O = creatine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693558", "l": "Gap-filling DNA synthesis in SDSA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218806", "l": "FYN autophosphorylates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166726", "l": "Activation of MASPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0052842", "l": "inositol diphosphate pentakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21603", "l": "anthranilate + benzoyl-CoA <=> CoA + N-benzoylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888577", "l": "Synthesis of GABA by GAD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9702849", "l": "CALCR binds gepants (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28514", "l": "(R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67643", "l": "ATP + dZMP <=> ADP + dZDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2995330", "l": "COX10 transforms heme to heme O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69799", "l": "D-tryptophanyl-tRNA(Trp) + H2O = D-tryptophan + tRNA(Trp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617595", "l": "SGTA binds mislocalized membrane protein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75545", "l": "(2E)-decenoyl-[ACP] + glycine + H2O => (3R)-3-[(carboxylmethyl)amino]decanoate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004427", "l": "inorganic diphosphate phosphatase activity", "d": ["Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019176", "l": "dihydroneopterin monophosphate phosphatase activity", "d": ["Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33988", "l": "(+)-copalyl diphosphate => diphosphate + neoabietadiene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174209", "l": "Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65387", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O <=> (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69062", "l": "H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+) => N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008061", "l": "chitin binding", "d": ["Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74303", "l": "12alpha-hydroxy-3-oxochola-4-en-24-oate + NAD(+) = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43239", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dihexadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35931", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852019", "l": "MET bound PI3K generates PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48729", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008473", "l": "ornithine cyclodeaminase activity", "d": ["Catalysis of the reaction: L-ornithine = L-proline + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39064", "l": "NADP(+) + scyllo-inositol => H(+) + NADPH + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5228992", "l": "ROCK1,ROCK2 are activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784494", "l": "EKC complex threonylcarbamoylates A37 of tRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.71648590403835", "identifiers": [{"i": "GO:0061651", "l": "Atg12 conjugating enzyme activity", "d": ["Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y = Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57735", "l": "A + all-trans-7,8-dihydroretinol <=> AH2 + all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0004332", "l": "fructose-bisphosphate aldolase activity", "d": ["Catalysis of the reaction: beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54847", "l": "H(+) + hexan-3-one + NADPH + O2 <=> ethyl butanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68418", "l": "(2R,3S)-iso(homo)2citrate => cis-(homo)2aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52274", "l": "gramine + H(+) + S-adenosyl-L-homocysteine => (1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63183", "l": "NADPH + 2 O2 <=> H(+) + NADP(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806831", "l": "CYB5Rs reduce MetHb to HbA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3318415", "l": "ATF2 acetylates histone H2B, H4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78228", "l": "D-histidine + H2O + O2 => 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55441", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49743", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate <=> CO2 + deoxyviolacein + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879942", "l": "The receptor is activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761186", "l": "Expression of OSR1 in intermediate mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15221", "l": "a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.26", "l": "\"CDP-diacylglycerol diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446221", "l": "GMPPB converts Mannose-1-phosphate to GDP-Mannose (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71300", "l": "chloride(out) + L-isoleucine(out) + 2 Na(+)(out) => chloride(in) + L-isoleucine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865774", "l": "TTLLs polyglutamylate tubulin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69562", "l": "D-mannose(in) + H(+)(in) => D-mannose(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77094", "l": "Formation of cap binding complex (CBC) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10744", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) = 3,4-dihydroxybenzoate + CO2 + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.53", "l": "\"(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22646", "l": "6-hydroxyprotopine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + protopine + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675194", "l": "Activated MAPK phosphorylates RAF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213207", "l": "Formation of collagen networks (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708457", "l": "HM13 cleaves HMOX1 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683546", "l": "FURIN binds furin inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52573", "l": "butanoyl-CoA + NAD(+) => (2E)-butenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53605", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50550", "l": "H2O + prostaglandin A1 => prostaglandin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781001", "l": "EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33128", "l": "H2O + salicin-6-phosphate => beta-D-glucose 6-phosphate + salicyl alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76190", "l": "an L-amino acid tripeptide(out) + 2 H(+)(out) <=> an L-amino acid tripeptide(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56088", "l": "a globoside MSGG + CMP-N-acetyl-beta-neuraminate = a globoside DSGG + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28313", "l": "beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31687", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781899", "l": "USP13 binds SIAH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.24", "l": "\"quinate/shikimate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56575", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose <=> a globoside Gb3Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12998", "l": "(E)-feruloyl-CoA + galactarate => 2-O-[(E)-feruloyl]-D-galactarate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18591", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate => [glutamine synthetase]-L-tyrosine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46731", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 <=> (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031220", "l": "maltodextrin phosphorylase activity", "d": ["Catalysis of the reaction: maltodextrin = glucose-1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865454", "l": "CBFB binds RUNX3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174255", "l": "Degradation multiubiquitinated Cyclin A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39292", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729260", "l": "GSK3 phosphorylates nucleoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69068", "l": "RFC dissociates after sliding clamp formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38712", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52607", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP <=> 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6802973", "l": "PLK3 phosphorylates CDC25C (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786650", "l": "DDHD1,2 hydrolyse PA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50696", "l": "calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824586", "l": "MITF-M-dependent DCT gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49130", "l": "5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine => AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68962", "l": "7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine => 7,8-dihydroxycoumarin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69074", "l": "Formation of Processive Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58455", "l": "N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672969", "l": "Phosphorylation of RAF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56363", "l": "13-deoxycarminomycin + H(+) + NADPH + O2 <=> 13-dihydrocarminomycin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2203516", "l": "Alpha-1-Microglobulin is cleaved (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69742", "l": "phenylsuccinate + succinyl-CoA <=> 3-phenylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20238", "l": "(1S,4S)-5-oxo-1,2-campholide => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098919", "l": "structural constituent of postsynaptic density", "d": ["The action of a molecule that contributes to the structural integrity of a postsynaptic density."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70511", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.127", "l": "\"3-(3-hydroxy-phenyl)propanoic acid hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32245", "l": "D-ribulose 1,5-bisphosphate => alpha-D-ribose 1,5-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047406", "l": "beta-aspartyl-N-acetylglucosaminidase activity", "d": ["Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-D-glucosamine + L-asparagine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9689680", "l": "IFNG dimer binds IFNG inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19381", "l": "(S)-oxalosuccinate + H(+) = 2-oxoglutarate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63897", "l": "aspulvinone E + hnu => isoaspulvinone E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77028", "l": "D-serine + H2O + NAD(+) => 3-hydroxypyruvate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814409", "l": "CK2 phosphorylates PDCL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001052", "l": "plastid PEP RNA polymerase core enzyme binding", "d": ["Binding to a bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789325", "l": "Expression of IL13-downregulated extracellular proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32247", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22085", "l": "(S)-2,3-diaminopropanoate + H(+) + H2O => 2 NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65626", "l": "CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine => hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9675026", "l": "Formation of the MLL1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12697", "l": "ATP + dGMP = ADP + dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44529", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53087", "l": "[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40885", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163672", "l": "Phosphorylation of ChREBP at Thr(653) by PKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16596", "l": "3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine <=> 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32710", "l": "(2E)-geranyl diphosphate <=> (2R,4S)-bornyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18664", "l": "H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) <=> H(+) + L-ornithine + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904854", "l": "proteasome core complex binding", "d": ["Binding to a proteasome core complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19972", "l": "hydroxylamine + O2 <=> H(+) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23757", "l": "D-arabinono-1,4-lactone + O2 => dehydro-D-arabinono-1,4-lactone + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10232", "l": "5,6-dihydrouridine 5'-phosphate + diphosphate = 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate", "d": [], "t": []}, {"i": "EC:2.4.2.20", "l": "\"dioxotetrahydropyrimidine phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70892", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(out) => L-asparagine(in) + L-glutamine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18226", "l": "[N-(6-aminohexanoyl)](n) + H2O => 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19701", "l": "a flavonol 3-O-glycoside + UDP-alpha-D-xylose = a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.35", "l": "\"flavonol-3-O-glycoside xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18831", "l": "(R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH => 4-phospho-D-erythronate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49930", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.81", "l": "\"hydroxypyruvate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50606", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] => acetyl-CoA + N-terminal L-methionyl-[transmembrane protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52499", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55474", "l": "9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806629", "l": "Formation of tonofilament bundles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17765", "l": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)", "d": [], "t": []}, {"i": "EC:5.4.2.4", "l": "\"bisphosphoglycerate mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45979", "l": "3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24598", "l": "CoA + H(+) + N(alpha)-acetyl-L-histidine => acetyl-CoA + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52063", "l": "12-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22080", "l": "H(+) + NADH + O2 + quinolin-2-ol = H2O + NAD(+) + quinoline-2,8-diol", "d": [], "t": []}, {"i": "EC:1.14.13.61", "l": "\"2-hydroxyquinoline 8-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655839", "l": "Expression of Phosphomevalonate Kinase (PMVK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381644", "l": "ER calcium channels open in response to activated PKA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222020", "l": "NUAK1 phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061821", "l": "telomeric D-loop binding", "d": ["Binding to a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78526", "l": "2-deoxy-2,3-dehydro-N-acetylneuraminate + H2O <=> N-acetyl-alpha-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164834", "l": "Enzyme-bound ATP is released (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485111", "l": "Collagen type III degradation by MMP10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.172", "l": "\"3,5,6-trichloropyridin-2-ol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77063", "l": "1-cyclohexylethanamine + H2O + NADP(+) = 1-cyclohexylethanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35614", "l": "menadiol + 2 O2 <=> 2 H(+) + menadione + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-354173", "l": "Activation of Rap1 by cytosolic GEFs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264871", "l": "Caspase-mediated cleavage of Lamin B1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634886", "l": "NPAS4 binds RBFOX3 (NeuN) gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76017", "l": "(3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate trimer + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56513", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51172", "l": "cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.82", "l": "\"glutamyl endopeptidase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0045159", "l": "myosin II binding", "d": ["Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114361", "l": "SMAC binds XIAP within apoptosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578712", "l": "Importin-8 binds AGO2:miRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164510", "l": "Conformational change in gp120 of Env oligomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50029", "l": "H2O + tetradecanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23258", "l": "adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate => adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57316", "l": "ATP + cytidine 5'-diphosphoramidate = ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.224", "l": "\"cytidine diphosphoramidate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004167", "l": "dopachrome isomerase activity", "d": ["Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25939", "l": "8-methylquinoline + A + H2O <=> 8-methylquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11108", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.17", "l": "\"chondroitin 6-sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73396", "l": "L-aspartate(in) + sulfate(out) => L-aspartate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35556", "l": "cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30918", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26252", "l": "H(+) + levopimaradienol + NADPH + O2 <=> 2 H2O + levopimaradienal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432427", "l": "PP1 dephosphorylates phosphorylated TIM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797090", "l": "CCNK binds CDK12 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70358", "l": "1-carboxybiuret + H(+) <=> biuret + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19939", "l": "H(+) + S-adenosyl-L-homocysteine + sarcosine => glycine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75769", "l": "10-hydroxyhexadecanoate => (9Z)-hexadecenoate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21461", "l": "benzoin => 2 benzaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690702", "l": "LYN phosphorylates CD22 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42687", "l": "gamma-L-glutamyl-hercynylcysteine S-oxide + H2O <=> L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57747", "l": "[protein]-disulfide + phylloquinol <=> [protein]-dithiol + phylloquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031757", "l": "Edg-4 lysophosphatidic acid receptor binding", "d": ["Binding to an Edg-4 lysophosphatidic acid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69299", "l": "CDT1 binds geminin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196929", "l": "FLAD1 phosphorylates FMN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102091", "l": "phosphatidylinositol-5-phosphate phosphatase activity", "d": ["Catalysis of the reaction: H2O + a 1-phosphatidyl-1D-myo-inositol 5-phosphate = an 1-phosphatidyl-1D-myo-inositol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75227", "l": "H2O + L-xylono-1,4-lactone = H(+) + L-xylonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62877", "l": "AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate => A + semiviriditoxin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018520", "l": "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52464", "l": "17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55288", "l": "tetradecan-1-ol + tetradecanoyl-CoA = CoA + tetradecanyl tetradecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163688", "l": "Dephosphorylation of pChREBP (Thr 666) by PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13806", "l": "A + a 3-oxo-5alpha-steroid => a 3-oxo-Delta(4)-steroid + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985343", "l": "RUNX2 binds SOX9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51951", "l": "(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61138", "l": "CO2 + H(+) + H2O + quercetin + succinate => (2R,3R)-dihydroquercetin + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625482", "l": "PTK2 binds activated EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56991", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866858", "l": "CFTR F508del is degraded by the 26S proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933292", "l": "LSR trimer binds VLDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22315", "l": "5-(methylsulfanyl)-D-ribose + ATP <=> ADP + H(+) + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54732", "l": "N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.110", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39985", "l": "a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O => a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373724", "l": "Nephrin binds NCK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65794", "l": "3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77077", "l": "Capping complex formation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0015573", "l": "beta-glucoside transmembrane transporter activity", "d": ["Enables the transfer of beta-glucosides from one side of a membrane to the other. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46866", "l": "a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68574", "l": "L-tyrosine(out) => L-tyrosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31562", "l": "L-galactose + NAD(+) <=> H(+) + L-galactono-1,4-lactone + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683840", "l": "SFTPB gene produces pro-SFTPB protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22280", "l": "O-demethylpuromycin + S-adenosyl-L-methionine = H(+) + puromycin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.38", "l": "\"O-demethylpuromycin O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61912", "l": "ATP + H2O + voriconazole(in) = ADP + H(+) + phosphate + voriconazole(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48882", "l": "a quinol + CO2 => a quinone + CO + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33430", "l": "(S)-malyl alpha-D-glucosaminide + L-cysteine <=> bacillithiol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71460", "l": "H2O + substance P => L-Leu-L-Met-NH2 + substance P(1-9)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199839", "l": "AKT can phosphorylate RSK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24420", "l": "H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]", "d": [], "t": []}, {"i": "EC:3.5.1.88", "l": "\"peptide deformylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953013", "l": "E2F7 binds E2F8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168848", "l": "tBID binds to inactive BAK protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31082", "l": "3-hydroxyisovaleryl-CoA <=> 3-methyl-(2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617828", "l": "TRIP11:IFT20 dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623643", "l": "RDH13 reduces atRAL to atROL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102511", "l": "pelargonidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose = pelargonidin 3,7-di-O-beta-D-glucoside + vanillate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57961", "l": "dimethyl sulfide + H(+) + NADH + O2 => dimethyl sulfoxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41902", "l": "3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + malonyl-[ACP] + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692755", "l": "CDK1 phosphorylates MAPK6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014456", "l": "GDIs block activation of RHOG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.48", "l": "\"carnitine--CoA ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58429", "l": "(E,E)-2,4-hexadien-1-ol + NADP(+) => (E,E)-2,4-hexadienal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015265", "l": "urea channel activity", "d": ["Enables the energy-independent facilitated diffusion of urea through a transmembrane aqueous pore or channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30750", "l": "FAD + H(+) + hexadecanoyl-CoA <=> (2E)-hexadecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24946", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) <=> (4S)-4-hydroxy-L-glutamate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102442", "l": "syringetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine = 3,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11886", "l": "adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+) => 3'-phosphoadenylyl sulfate + cortisol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55823", "l": "a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210439", "l": "glutamate uptake by astrocytes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612440", "l": "ERBB4s80 binds the MXD4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63566", "l": "apelin-12 + L-phenylalanine => apelin-13 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1671687", "l": "PRLR activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229283", "l": "LCNs bind lipids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51368", "l": "glycine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49044", "l": "H(+) + NADH + O2 + protoasukamycin = 4-hydroxyprotoasukamycin + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.215", "l": "\"protoasukamycin 4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31755", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + H2O = 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde", "d": [], "t": []}, {"i": "EC:3.3.2.12", "l": "\"oxepin-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.24", "l": "\"ribonuclease T1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29685", "l": "alpha-D-glucose 1-phosphate + alpha-maltopentaose => alpha-maltohexaose + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42342", "l": "4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH => 4-(gamma-L-glutamylamino)butanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31136", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate => 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54436", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 = a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617471", "l": "HOXA1 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19531", "l": "H(+) + isovitexin 2''-O-beta-D-glucoside + UDP => isovitexin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43888", "l": "[sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine = [sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.18", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22027", "l": "H2O + NAD(+) + trimethylamine <=> 2 H(+) + NADH + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38343", "l": "(20S)-ginsenoside Rd + H2O = (20S)-ginsenoside Rg3 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50632", "l": "a 2-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50149", "l": "a fatty acid ethyl ester + H2O => a fatty acid + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20664", "l": "D-alanyl-D-alanine + H2O <=> 2 D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35972", "l": "12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate => diphosphate + fumitremorgin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29687", "l": "alpha-maltoheptaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltohexaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.3", "l": "\"plant seed peroxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620915", "l": "BTG1 gene expression is stimulated by FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424476", "l": "Activation of RAC1 by VAV2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57591", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696267", "l": "RND3 binds GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32940", "l": "a 1,2-diacyl-sn-glycerol + CDP-choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162253", "l": "PDSS1,2 ligates FPP to IPPP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0004904", "l": "interferon receptor activity", "d": ["Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77281", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59202", "l": "diphosphate + docosanoyl-AMP => ATP + docosanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75079", "l": "Formation of AT-AC C complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67890", "l": "3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19862", "l": "a 16alpha-hydroxysteroid + NAD(+) => a 16-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0003922", "l": "GMP synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13132", "l": "cis-4-coumarate + UDP-alpha-D-glucose <=> 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70245", "l": "a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2262777", "l": "TRAF6 binds to p-IRAK2   (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29001", "l": "H(+)(in) + homoserine lactone(out) => H(+)(out) + homoserine lactone(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63980", "l": "4-thiouridine + ATP = 4-thiouridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77094", "l": "Formation of cap binding complex (CBC) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004506", "l": "squalene monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + squalene = (S)-2,3-epoxysqualene + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103072", "l": "straight chain (R)-2-hydroxy fatty acyl-CoA lyase activity", "d": ["Catalysis of the reaction: a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA = formyl-CoA + an odd numbered straight chain 2,3,4-saturated fatty aldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050004", "l": "isoflavone 7-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15389", "l": "ATP = 3',5'-cyclic AMP + diphosphate", "d": [], "t": []}, {"i": "EC:4.6.1.1", "l": "\"adenylate cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11304", "l": "(S)-ureidoglycolate = glyoxylate + urea", "d": [], "t": []}, {"i": "EC:4.3.2.3", "l": "\"ureidoglycolate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28005", "l": "beta-D-fructose 6-phosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706319", "l": "Active FLT3 binds to SLA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57615", "l": "20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH <=> 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51563", "l": "(S)-bulbocapnine + S-adenosyl-L-methionine <=> (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64278", "l": "chrysophanol + H2O => chrysophanol-9-anthrone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76867", "l": "(R)-1-phenylethylamine + H2O + NAD(+) = acetophenone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047367", "l": "quercetin-3,3'-bissulfate 7-sulfotransferase activity", "d": ["Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856808", "l": "Recruitment of AP-2 complex and clathrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25105", "l": "ATP + pyridoxamine => ADP + H(+) + pyridoxamine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60039", "l": "H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate <=> 3-hydroxy-3-methylhexanoate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047710", "l": "bis(5'-adenosyl)-triphosphatase activity", "d": ["Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65643", "l": "(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41341", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 => 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850797", "l": "SPINK6 binds KLK13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047591", "l": "5-hydroxypentanoate CoA-transferase activity", "d": ["Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013990", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848774", "l": "PTK6 binds DOK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70993", "l": "H(+)(out) + L-mannopyranose(out) => H(+)(in) + L-mannopyranose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38990", "l": "nonanoyl-CoA + O2 <=> (2E)-nonenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66954", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+) => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36686", "l": "hexadecanoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-hexadecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21133", "l": "H2O + O2 + xanthine => H2O2 + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803892", "l": "SFN dimer binds BAX (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51809", "l": "(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74987", "l": "erythrostominone(in) = erythrostominone(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047047", "l": "oxaloglycolate reductase (decarboxylating) activity", "d": ["Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592240", "l": "Formation of NRF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72510", "l": "2-oxoglutarate(in) + prostaglandin F2alpha(out) <=> 2-oxoglutarate(out) + prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28226", "l": "(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.149", "l": "\"5-epiaristolochene 1,3-dihydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9842669", "l": "Active LTK recruits GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112342", "l": "Inactivation of MAP2K1 by CDK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009037", "l": "tyrosine-based site-specific recombinase activity", "d": ["Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166542", "l": "beta-NGF dimer binds to TrkA receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78254", "l": "D-threonine + H2O + O2 <=> (S)-3-hydroxy-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14106", "l": "L-proline + NAD(+) => 1-pyrroline-5-carboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77461", "l": "(2S)-2-hydroxy-2-(thiophen-3-yl)acetonitrile => 3-formylthiophene + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0004738", "l": "pyruvate dehydrogenase activity", "d": ["Catalysis of the oxidative decarboxylation of pyruvate."], "t": []}, {"i": "REACT:R-HSA-71397", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45066", "l": "ethanolamine + hexadecanoate => H2O + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805640", "l": "AKT phosphorylates KAT6A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62399", "l": "(1S,2S)-pseudoephedrine + NAD(+) <=> (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67615", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37311", "l": "ATP + glycyl-L-glutamine(out) + H2O = ADP + glycyl-L-glutamine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944218", "l": "Association of procollagen type VIII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13217", "l": "H2O + NAD(+) + succinate semialdehyde = 2 H(+) + NADH + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806423", "l": "TP53 stimulates DDB2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56668", "l": "7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.116", "l": "\"7beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50669", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675431", "l": "PP2A dephosphorylates RAF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796050", "l": "AcK-NFE2L2 binds the KEAP1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1006169", "l": "Factor H binds host cell surface markers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32568", "l": "(2E)-geranyl diphosphate => (1R,4S)-camphene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13790", "l": "[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30119", "l": "dodecanoyl-[ACP] + H2O = dodecanoate + H(+) + holo-[ACP]", "d": [], "t": []}, {"i": "EC:3.1.2.21", "l": "\"dodecanoyl-[acyl-carrier-protein] hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78402", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> astellifadiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604499", "l": "Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65640", "l": "(4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39922", "l": "1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O <=> 1-O-(alk-1-enyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78358", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34522", "l": "N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine <=> [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209295", "l": "Phosphorylated DL/DIF dimer transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24516", "l": "acetyl-CoA + gentamicin C1a = CoA + H(+) + N(2')-acetylgentamicin C1a", "d": [], "t": []}, {"i": "EC:2.3.1.59", "l": "\"gentamicin 2'-N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77556", "l": "a 3-acyl-sn-glycerol + an acyl-CoA => a 1,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41038", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12205", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679044", "l": "FKBP1A binds sirolimus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27279", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53768", "l": "allocholate + allodeoxycholoyl-CoA = allocholoyl-CoA + allodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141002", "l": "histone H4K16 propionyltransferase activity", "d": ["Catalysis of the reaction: histone H4 L-lysine (position 16) + propionyl-CoA = CoA + H+ + histone H3 N6-propionyl-L-lysyl (position 16)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27853", "l": "glycine + phenylacetyl-CoA <=> CoA + H(+) + phenylacetylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40968", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37750", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine <=> 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050241", "l": "pyrroline-2-carboxylate reductase activity", "d": ["Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0070883", "l": "pre-miRNA binding", "d": ["Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004414", "l": "homoserine O-acetyltransferase activity", "d": ["Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052774", "l": "glucosyl-N-acetylglucosamine glucosaminidase activity", "d": ["Catalysis of the reaction: glucosyl-N-acetylglucosamine + H2O = glucosamine + N-acetylglucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20010", "l": "2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose => H(+) + linamarin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990930", "l": "mRNA N1-methyladenosine dioxygenase activity", "d": ["Catalysis of the oxidative demethylation of N1-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenosine as formaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38753", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354087", "l": "Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64968", "l": "dUTP + H2O = dUDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050013", "l": "2-dehydropantoate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74776", "l": "kaempferide + S-adenosyl-L-methionine => 7,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76880", "l": "3-aminobutan-2-ol + H2O + NAD(+) => acetoin + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44115", "l": "hexadecanoyl-CoA + nonan-1-ol <=> CoA + nonyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15337", "l": "H2O + phenylglyoxylyl-CoA = CoA + H(+) + phenylglyoxylate", "d": [], "t": []}, {"i": "EC:3.1.2.25", "l": "\"phenylacetyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24412", "l": "4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.257", "l": "\"4-(hydroxymethyl)benzenesulfonate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33787", "l": "3'-ketolactose + H2O = 3-keto-beta-D-galactose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16230", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) => a CDP-1,2-diacyl-sn-glycerol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12641", "l": "(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.95", "l": "\"phosphoglycerate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57275", "l": "a 2'-deoxyguanosine in DNA + methylglyoxal <=> an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43768", "l": "an alkylamine + L-glutaminyl-[protein] = N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421835", "l": "trans-Golgi Network Vesicle Scission (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047400", "l": "phosphonoacetate hydrolase activity", "d": ["Catalysis of the reaction: H2O + phosphonoacetate = acetate + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74445", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in) => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40477", "l": "butanoate + dibutanoylglycerol + H(+) => 1,2,3-tributanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58725", "l": "adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70510", "l": "LDH tetramer oxidises LACT to PYR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618811", "l": "Calcium binds calmodulin at the synapse (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851979", "l": "BTNL9 binds immune cell surfaces (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37456", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865547", "l": "RUNX1:CBFB binds FOXP3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803761", "l": "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784620", "l": "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047608", "l": "acetylindoxyl oxidase activity", "d": ["Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018480", "l": "5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59813", "l": "hexadecanoyl-CoA + N-terminal glycyl-[protein] => CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648883", "l": "p-T-EIF2AK1:ferriheme dimer autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730841", "l": "Phosphorylation and activation of VAV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662606", "l": "MT3 binds zinc (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46151", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O <=> a 2'-deoxyribonucleoside + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64737", "l": "4-hydroxynonanal + NADP(+) => (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11347", "l": "an N-acylneuraminate + CTP <=> a CMP-N-acyl-beta-neuraminate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-996727", "l": "REST recruits the BHC complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12255", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + H2O <=> (E)-coniferol + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251557", "l": "Expression of AMER1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66035", "l": "alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16687", "l": "a dolichyl hexadecanoate + CoA => di-trans,poly-cis-dolichol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77859", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-phenylalanine + O2 = (2S)-3-phenyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102863", "l": "1-18:3-2-18:1-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657651", "l": "MGMT binds alkylated DNA containing 6-O-methylguanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25187", "l": "2-chloroethanol + chloride + H(+) => 1,2-dichloroethane + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35616", "l": "hydroxyacetone + NAD(+) => H(+) + methylglyoxal + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52320", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryptamine = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74491", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B = yaequinolone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60123", "l": "(2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine <=> H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.263", "l": "\"abscisate beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31578", "l": "8-oxo-dGTP + H2O <=> 8-oxo-dGMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23750", "l": "diphosphate + pppGp(2'-5')A => ATP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909738", "l": "SHP1 and SHP2 bind the common beta chain (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33577", "l": "a mannosylinositol-1-phosphophytoceramide + H2O => an inositol-1-phosphophytoceramide + beta-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36994", "l": "phosphate + UMP <=> alpha-D-ribose 1,5-bisphosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210273", "l": "Interaction of DAP12 and NKp44 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851127", "l": "NPM1-ALK-dependent repression of pRB phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803836", "l": "FGFR2b-specific alternative splicing produces FGFR2b transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30772", "l": "guanosine + H2O => D-ribose + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60262", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668605", "l": "RAC2:GTP binds NOX2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24621", "l": "NAD(+) + octan-1-ol => H(+) + NADH + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163090", "l": "Elongation Of The Telomeric Chromosome End (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357483", "l": "RAC1 binds PAK1-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59454", "l": "a long-chain fatty aldehyde + H(+) + NADPH => a long-chain primary fatty alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50594", "l": "15-oxoprostaglandin F1alpha + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061663", "l": "NEDD8 ligase activity", "d": ["Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S = X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate."], "t": []}, {"i": "EC:2.3.2.32", "l": "\"cullin-RING-type E3 NEDD8 transferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65849", "l": "A + a 3-oxo-Delta(1)-steroid + H2O => a steroid 1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785181", "l": "LMF1,2 bind LIPC dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71917", "l": "2 Na(+)(in) + tauronorcholate(in) => 2 Na(+)(out) + tauronorcholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11658", "l": "AMP + diphosphate + L-prolyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033450", "l": "GUC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GUC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40489", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53884", "l": "CDP-alpha-D-glucose + D-glucose 6-phosphate = alpha,alpha-trehalose 6-phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58753", "l": "1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000830", "l": "inositol hexakisphosphate 4-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381496", "l": "Formation of the IGF:IGFBP3:ALS complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34046", "l": "5-phospho-alpha-D-ribose 1-diphosphate + neamine <=> 5''-phosphoribostamycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047784", "l": "cortisol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10383", "l": "diphosphate + orotidine 5'-phosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67356", "l": "(2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA = (2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59903", "l": "2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 <=> CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31330", "l": "1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol <=> bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44803", "l": "1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-6 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180725", "l": "Rev associates with B23 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69625", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004648", "l": "O-phospho-L-serine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662619", "l": "MT1H binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33700", "l": "C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57791", "l": "1,3-dinitrobenzene + NADH + O2 <=> 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39411", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA = (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.255", "l": "\"protein O-GlcNAc transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839384", "l": "Inhibin-A binding to TGFBR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33379", "l": "4-hydroxyeicosasphinganine 1-phosphate + H2O = (4R)-hydroxyeicosasphinganine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797553", "l": "Protein 4.1 binds CASK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.-", "l": "\"Miscellaneous\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5226979", "l": "ADD1:ADD2 binds DMTN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008456", "l": "CDKN1A gene expression is inhibited by RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46130", "l": "4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621370", "l": "SYK autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45481", "l": "gamma-hexachlorocyclohexane => (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48111", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.28", "l": "\"aromatic-L-amino-acid decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65953", "l": "2 a quinone + H(+) + NADH => 2 a 1,4-benzosemiquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022877", "l": "protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052893", "l": "N1-acetylspermine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38427", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74728", "l": "acetyl-CoA + 10 H(+) + holo-[polyketide synthase] + 5 malonyl-CoA + 5 NADPH => 5 CO2 + 6 CoA + dodecapentaneoyl-[polyketide synthase] + 5 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37564", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55950", "l": "AH2 + NH4(+) + pyruvate => A + D-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839363", "l": "TGFBR3 phosphorylation by TGFBR2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74001", "l": "diphosphate + peniprequinolone => dimethylallyl diphosphate + quinolinone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23545", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32347", "l": "2 S-adenosyl-L-methionine + tricetin = 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.175", "l": "\"tricin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534359", "l": "CatSper Channel Mediated Calcium Transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169919", "l": "Glycosylation of NA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052770", "l": "coenzyme F390-A hydrolase activity", "d": ["Catalysis of the reaction: coenzyme F390-A = AMP + coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28442", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + dodecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382061", "l": "Extracellular processing of novel PDGFs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000433", "l": "SUMOylation of PML with SUMO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42808", "l": "2 H(+) + 3 H2O + hydrogen sulfide + 3 oxidized coenzyme F420-(gamma-L-Glu)(n) = 3 reduced coenzyme F420-(gamma-L-Glu)(n) + sulfite", "d": [], "t": []}, {"i": "EC:1.8.98.3", "l": "\"sulfite reductase (coenzyme F420)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0030548", "l": "acetylcholine receptor regulator activity", "d": ["Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706312", "l": "Active FLT3 binds to LCK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24205", "l": "acetyl phosphate + H(+) + sulfite => phosphate + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51033", "l": "7-chloroindole-3-pyruvate imine dimer => dichlorochromopyrrolate + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47700", "l": "H(+) + ketocytochalasin + NADPH + O2 = H2O + iso-precytochalasin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45264", "l": "(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-octadecadienoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983147", "l": "Release of E3 from polyubiquitinated substrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.323347803118935", "identifiers": [{"i": "GO:0004029", "l": "aldehyde dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61844", "l": "solasodine + UDP-alpha-D-glucose = H(+) + solasodine 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50698", "l": "calcidiol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => calciol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13627", "l": "3-methyl-2-butenal + adenine + AH2 => A + H2O + N(6)-dimethylallyladenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58890", "l": "4-nitrobenzoate + A + 2 H2O => 4-aminobenzoate + AH2 + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57008", "l": "5,5'-dehydrodivanillate + H(+) + NADH + O2 = 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55238", "l": "(9Z)-octadecenoate + 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0034601", "l": "oxoglutarate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + CoA + NAD(P)+ = succinyl-CoA + CO2 + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369028", "l": "ABCAs mediate lipid efflux (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51268", "l": "norbelladine + S-adenosyl-L-methionine = 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.336", "l": "\"norbelladine O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64114", "l": "a fatty acid + L-phenylalanine => an N-acyl-L-phenylalanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011543", "l": "DCA binds PDK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450325", "l": "c-FOS activation by phospho ERK1/2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11722", "l": "ADP + 2 H(+) + N-carbamoylsarcosine + phosphate => ATP + 2 H2O + N-methylhydantoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44542", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31732", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 => 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3772430", "l": "CTNNBIP1 binds beta-catenin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70978", "l": "3-sulfino-L-alanine(out) + L-aspartate(in) <=> 3-sulfino-L-alanine(in) + L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868236", "l": "BAR domain proteins recruit dynamin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11822", "l": "H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide => diphthamide-[translation elongation factor 2] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45017", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine => L-selenomethionine + tetrahydropteroyltri-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39120", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 => (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67105", "l": "2-oxoglutarate + fumigatonoid C + O2 => CO2 + H2O + novofumigatonin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75616", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate => ectocarpin B + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429860", "l": "DCP1-DCP2 complex decaps mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-434650", "l": "MATEs mediate extrusion of xenobiotics (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46554", "l": "a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788975", "l": "Superoxide anion dismutates to H2O2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64453", "l": "L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.10", "l": "\"UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672969", "l": "Phosphorylation of RAF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400500", "l": "Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49174", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67341", "l": "malonyl-CoA + quercetin 3-O-beta-D-glucoside => CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23422", "l": "alpha,alpha-trehalose + phosphate => alpha,alpha-trehalose 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015209", "l": "cytosine transmembrane transporter activity", "d": ["Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388828", "l": "PD-1 binds B7DC and B7H1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050194", "l": "phosphonoacetaldehyde hydrolase activity", "d": ["Catalysis of the reaction: H2O + phosphonoacetaldehyde = acetaldehyde + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14441", "l": "acetyl-CoA + gentamicin C = CoA + H(+) + N(3)-acetylgentamycin C", "d": [], "t": []}, {"i": "EC:2.3.1.60", "l": "\"gentamicin 3-N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18085", "l": "coenzyme B + coenzyme M + methanophenazine = coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine", "d": [], "t": []}, {"i": "EC:1.8.98.1", "l": "\"dihydromethanophenazine:CoB--CoM heterodisulfide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734687", "l": "ORC6 is phosphorylated on T195 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851979", "l": "BTNL9 binds immune cell surfaces (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42479", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + O2 <=> 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72744", "l": "leukotriene C4(out) => leukotriene C4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53441", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102051", "l": "indole-3-acetyl-tryptophan synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-tryptophan + ATP(4-) = H+ + indole-3-acetyl-tryptophan + AMP(2-) + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39446", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32609", "l": "(6E)-8-hydroxygeranial + H(+) + NADPH => (6E)-8-hydroxygeraniol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688838", "l": "RIPK3 binds STUB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41869", "l": "decanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682598", "l": "ATM phosphorylates HERC2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24288", "l": "5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine", "d": [], "t": []}, {"i": "EC:2.1.2.4", "l": "\"glycine formimidoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78963", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029680", "l": "Caspase-7 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78292", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => (R,2E)-alpha-cericerene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31895", "l": "(2E,6E)-farnesyl diphosphate = alpha-humulene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.104", "l": "\"alpha-humulene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71466", "l": "H2O + substance P <=> Gly-L-Leu-L-Met-NH2 + substance P(1-8)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19347", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13436", "l": "2'-deoxycytidine + H(+) + H2O <=> 2'-deoxyuridine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61572", "l": "(11Z,14Z)-eicosadienoate + O2 = (15S)-hydroperoxy-(11Z,13E)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74548", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + talarodiene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59406", "l": "D-homoserine => L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44544", "l": "a fatty acid(out) + ATP + H2O = a fatty acid(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46832", "l": "4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH = 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033977", "l": "2-haloacid dehalogenase (configuration-retaining) activity", "d": ["Catalysis of the reactions: (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0140805", "l": "NAD+-protein-serine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]."], "t": []}, {"i": "RHEA:58232", "l": "L-seryl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928645", "l": "EPHB:NMDAR binds TIAM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617413", "l": "Expression of GLI2 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74616", "l": "UDP-alpha-D-galactose(in) + UDP-alpha-D-glucose(out) => UDP-alpha-D-galactose(out) + UDP-alpha-D-glucose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72576", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O => (22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16370", "l": "(R)-lactate + NAD(+) => H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55708", "l": "[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide", "d": [], "t": []}, {"i": "EC:2.4.2.60", "l": "\"cysteine-dependent adenosine diphosphate thiazole synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9632412", "l": "PTK2 is recruited to methylated ESR1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15146", "l": "D-maltose => alpha,alpha-trehalose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17950", "l": "3-hydroxy-1H-quinolin-4-one + O2 => CO + H(+) + N-formylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26452", "l": "H(+) + NADPH + succinyl-CoA => CoA + NADP(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31140", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) => 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000834", "l": "inositol heptakisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71239", "l": "2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0046977", "l": "TAP binding", "d": ["Binding to TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74002", "l": "dimethylallyl diphosphate + quinolinone B <=> diphosphate + peniprequinolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52610", "l": "2-oxobutanoate + H(+) + NADPH => 2-hydroxybutanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37638", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102866", "l": "di-homo-gamma-linolenate delta5 desaturase activity", "d": ["Catalysis of the reaction: all-cis-icosa-8,11,14-trienoate + O2 + a reduced electron acceptor = arachidonate + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9854405", "l": "Frataxin transfers Fe2+ to ACO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47448", "l": "(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29919", "l": "alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP = ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48888", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44998", "l": "CoA + O-3-oxobutanoyl-(R)-carnitine => (R)-carnitine + acetoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36716", "l": "sphinganine + tetracosenoyl-CoA => an N-tetracosenoylsphinganine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13554", "l": "alpha-D-galactose + ATP => ADP + alpha-D-galactose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61725", "l": "a D-glucoside + NAD(+) => a 3-dehydro-D-glucoside + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56367", "l": "13-dihydrocarminomycin + H(+) + NADPH + O2 <=> carminomycin + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25493", "l": "(2E)-geranyl diphosphate => (-)-beta-phellandrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.24", "l": "\"aminobenzoate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75860", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55851", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA <=> [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3785684", "l": "Fibronectin degradation by CTSG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043365", "l": "[formate-C-acetyltransferase]-activating enzyme activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18839", "l": "CoA + taxuyunnanin C => 10-deacetyltaxuyunnanin C + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78686", "l": "a 5'-end triphospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61811", "l": "holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP <=> AMP + H(+) + L-alanyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852337", "l": "GTSE1 binds TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31993", "l": "diphosphate + sesquithujene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43272", "l": "a ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GD2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31141", "l": "3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH => (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.109", "l": "\"sphingomyelin deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429815", "l": "Formation Of Bloc-1 Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928607", "l": "p-EPHs bind VAV2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77968", "l": "all-trans-hexaprenyl diphosphate => diphosphate + macrophomene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13604", "l": "cis-4-hydroxy-L-proline + NAD(+) <=> 4-oxo-L-proline + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64134", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine => H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678854", "l": "S1PR1 binds S1PR1 agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805276", "l": "CDK5 phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869683", "l": "oxPL binds LBP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37955", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38098", "l": "gamma-tocotrienol + S-adenosyl-L-methionine <=> alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.25.1", "l": "\"deoxyribonuclease (pyrimidine dimer)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848873", "l": "PTK6 phosphorylates ARAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984708", "l": "Kinesin-2 is a heterotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130706", "l": "MHC class II antigen processing (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211219", "l": "Translocation of caspase-3 to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047172", "l": "shikimate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30826", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62372", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2203480", "l": "COLEC11 binds ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761025", "l": "ZEB2 and SP1 bind CDH11 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30753", "l": "AMP + diphosphate + hexadecanoyl-CoA => ATP + CoA + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50204", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29449", "l": "glycolate(out) => glycolate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29393", "l": "diphosphate + GMP + H(+) => GTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74086", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + menadiol <=> diphosphate + menaquinol-4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22360", "l": "D-glutamate = 5-oxo-D-proline + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.48", "l": "\"D-glutamate cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.177", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61803", "l": "ATP + holo-[peptidyl-carrier protein] + L-alanine <=> AMP + diphosphate + L-alanyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.27", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.2.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59279", "l": "L-glutamine <=> D-glutamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031692", "l": "alpha-1B adrenergic receptor binding", "d": ["Binding to an alpha-1B adrenergic receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106153", "l": "phosphorylated histone binding", "d": ["Binding to a histone in which a residue has been modified by phosphorylation."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38088", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.50", "l": "\"bothrolysin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61854", "l": "campesteryl 3-beta-D-glucoside + H(+) + UDP => campesterol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.1.14", "l": "\"nocardicin-A epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25533", "l": "ent-copalyl diphosphate => diphosphate + ent-cassa-12,15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379864", "l": "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669250", "l": "PAK1 phosphorylates FLNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57211", "l": "glyoxal + L-cysteinyl-[protein] <=> S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045508", "l": "interleukin-26 receptor activity", "d": ["Combining with interleukin-26 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57441", "l": "2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] => 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35628", "l": "delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose => delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61364", "l": "ATP + dehydroepiandrosterone 3-sulfate(in) + H2O = ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.4", "l": "\"dipeptidyl-peptidase III\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176452", "l": "Degradation of ubiquitinated SMAD2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19423", "l": "(R)-1,2-epoxypropane + coenzyme M => (R)-2-hydroxypropyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26440", "l": "3-oxopropanoate + H(+) + NADPH => 3-hydroxypropanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56230", "l": "(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035375", "l": "zymogen binding", "d": ["Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805470", "l": "AMPK phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47819", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33376", "l": "a 1-acylglycerone 3-phosphate + H(+) + NADPH => a 1-acyl-sn-glycero-3-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006850", "l": "IL21 receptor JAK phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64308", "l": "3-aminobutanoate + pyruvate = acetoacetate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55785", "l": "all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate => all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77984", "l": "9-hydroxy-octadecanoate + a triacylglycerol => 9-(acyloxy)-octadecanoate + a 2,3-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388817", "l": "ICOS binds ICOSL/B7-H2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578965", "l": "TNRC6A binds AGO2:miRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51980", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22430", "l": "2 H2O + isopenicillin N => N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008941", "l": "nitric oxide dioxygenase NAD(P)H activity", "d": ["Catalysis of the reaction: 2 NO + 2 O2 + NAD(P)H + H+ = 2 nitrate + NAD(P)+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374896", "l": "Uptake of Noradrenaline (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33301", "l": "[eIF5A protein]-deoxyhypusine + propane-1,3-diamine => [eIF5A protein]-L-lysine + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16864", "l": "(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine <=> (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24455", "l": "L-glutamyl-[protein] + S-adenosyl-L-methionine <=> [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37494", "l": "4-coumaroyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749487", "l": "TP53 stimulates IKBIP gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944263", "l": "Association of procollagen type II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77820", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-alanine + O2 => 2-dehydro-D-glucose + H2O2 + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65855", "l": "a 3-oxo-Delta(1)-steroid + H2O <=> a 1-hydroxy-3-oxo steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63779", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051922", "l": "cholesterol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H+."], "t": []}, {"i": "RHEA:52368", "l": "3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74716", "l": "Insulin binds the insulin receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38850", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65486", "l": "CoA + hexyl hexanoate => hexan-1-ol + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13572", "l": "a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19774", "l": "NADP(+) + sn-glycerol 3-phosphate => D-glyceraldehyde 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102635", "l": "11-deoxycorticosterone reductase activity", "d": ["Catalysis of the reaction: 11-deoxycorticosterone + NADH + H+ = 4-pregnen-20,21-diol-3-one + NAD."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54867", "l": "H(+) + NADPH + O2 + sulcatone <=> 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.69", "l": "\"GDP-L-galactose/GDP-D-glucose: hexose 1-phosphate guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851018", "l": "BTN2A1 binds DC-SIGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618093", "l": "ATP hydrolysis by HSP90 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65732", "l": "2-oxoglutarate + heptyl sulfate + O2 = CO2 + H(+) + heptanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014454", "l": "RHOG translocates to the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448958", "l": "Nuclear translocation of p38 MAPK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16565", "l": "2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.38", "l": "\"histidine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46007", "l": "2-methylpropanal + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12373", "l": "2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O => 4-oxohex-2-enedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684096", "l": "CDK2 phosphorylates RBBP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72566", "l": "butanoate(out) + dehydroepiandrosterone 3-sulfate(in) <=> butanoate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75416", "l": "H2O + N-methylmyosmine => pseudooxynicotine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78412", "l": "carbendazim + H2O => 2-aminobenzimidazole + CO2 + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5225649", "l": "RBBP7 binds histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18857", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.138", "l": "\"lithocholate 6beta-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76657", "l": "3-methylbutanoate + 2 H(+) + NADH => 3-methylbutanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70971", "l": "ACO2 isomerizes citrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68985", "l": "a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine => a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9854405", "l": "Frataxin transfers Fe2+ to ACO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29234", "l": "cyanate(in) <=> cyanate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174119", "l": "Free APC/C phosphorylated by Plk1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944219", "l": "Association of procollagen type XVI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45917", "l": "12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000269", "l": "toxin export channel activity", "d": ["Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43070", "l": "4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase] => beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56791", "l": "apo-[corrinoid adenosyltransferase] + cob(II)alamin <=> cob(II)alamin-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31954", "l": "9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43052", "l": "3-(methylsulfanyl)propanoate + ATP + CoA = 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.44", "l": "\"3-(methylthio)propionyl--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20089", "l": "acetyl-CoA + L-leucine = CoA + H(+) + N-acetyl-L-leucine", "d": [], "t": []}, {"i": "EC:2.3.1.66", "l": "\"leucine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844610", "l": "NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73364", "l": "beta-alanyl-[peptidyl-carrier protein] + dopamine => beta-alanyl-dopamine + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61149", "l": "myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose => H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432121", "l": "LDL binds to LRP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53633", "l": "(2E,6E)-farnesyl diphosphate => (3S)-(+)-asterisca-2(9),6-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69721", "l": "(indol-3-yl)acetyl-AMP + diphosphate => (indol-3-yl)acetate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46741", "l": "7-dehydrodesmosterol + H(+) + NADPH => desmosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23857", "l": "H(+) + Hg + NADP(+) => Hg(2+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76150", "l": "perivine + S-adenosyl-L-methionine <=> 2 H(+) + S-adenosyl-L-homocysteine + vobasine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031878", "l": "type 1 somatostatin receptor binding", "d": ["Binding to a type 1 somatostatin receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20627", "l": "2 Fe(II)-[cytochrome c3] + 2 H(+) => 2 Fe(III)-[cytochrome c3] + H2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3159259", "l": "MMAA:MUT binds AdoCbl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77359", "l": "2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22402", "l": "17beta-hydroxyandrostanone + H(+) + NADH => androstan-3alpha,17beta-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858428", "l": "FCAMR binds IgA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13670", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102982", "l": "UDP-3-dehydro-alpha-D-glucose dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + NAD = H+ + UDP-3-keto-alpha-D-glucose + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76288", "l": "Na(+)(out) + thymine(out) => Na(+)(in) + thymine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23397", "l": "H2O + phloretin => 1,3,5-trihydroxybenzene + H(+) + phloretate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955844", "l": "RBKS phosphorylates ribose to R5P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045430", "l": "chalcone isomerase activity", "d": ["Catalysis of the reaction: a chalcone = a flavanone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35874", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9676160", "l": "AAMP binds NOD2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29040", "l": "ATP + H2O + L-aspartate(out) => ADP + H(+) + L-aspartate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9855910", "l": "USF1 is phosphorylated by p-MAPK14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0005356", "l": "glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196773", "l": "COASY phosphorylates DP-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854222", "l": "TBC1D3 associates with RAB5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982617", "l": "CYGB:O2 dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28705", "l": "Cu(2+)(out) => Cu(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55483", "l": "ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68556", "l": "NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine = H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66565", "l": "histamine + L-glutaminyl-[protein] => 5-histaminyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13833", "l": "L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.84", "l": "\"arginine--pyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69793", "l": "D-phenylalanine + H(+) + tRNA(Phe) => D-phenylalanyl-tRNA(Phe) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050158", "l": "dihydroorotate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + NADP+ = H+ + NADPH + orotate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788623", "l": "p-Y-STATs translocate to nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1297354", "l": "Acrosin Cleavage (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50285", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159771", "l": "Furin cleaves pro-protein C to protein C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22302", "l": "a flavonol 3-O-beta-D-glucoside + H(+) + UDP => a flavonol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55418", "l": "biochanin A 7-O-beta-D-glucoside + H(+) + UDP => biochanin A + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32178", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose <=> alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38828", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30440", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) => 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39176", "l": "(3R)-hydroxyeicosanoyl-CoA => (2E)-eicosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44182", "l": "(2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73009", "l": "D-glyceraldehyde 3-phosphate + glycolaldehyde => D-arabinose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77422", "l": "(E)-hex-2-enal + hydrogen cyanide <=> (2S,3E)-2-hydroxyhept-3-enenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672973", "l": "MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64217", "l": "2-carboxy-L-lyxonate + H(+) => CO2 + L-lyxonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017058", "l": "FH1 domain binding", "d": ["Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30754", "l": "ATP + CoA + hexadecanoate <=> AMP + diphosphate + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448678", "l": "CTSG cleaves CASP1(1-404) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0005539", "l": "glycosaminoglycan binding", "d": ["Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004830", "l": "tryptophan-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39252", "l": "(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH => (11Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63145", "l": "H2O + N-(15Z-tetracosenoyl)-ethanolamine => (15Z)-tetracosenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733292", "l": "AMY1-3 bind pramlintide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45992", "l": "(3R)-3-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67599", "l": "heptadecasphing-4-enine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46449", "l": "2 L-tyrosyl-tRNA(Tyr) => cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52502", "l": "(13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57759", "l": "2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187828", "l": "Translocation of p21 to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950347", "l": "IL12A:IL12B translocates from late endosome lumen to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35373", "l": "(beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate => 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193684", "l": "p62 recruits an atypical PKC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11135", "l": "chlorophyllide a + NADP(+) <=> H(+) + NADPH + protochlorophyllide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22040", "l": "H2O + N-formyl-L-aspartate = formate + L-aspartate", "d": [], "t": []}, {"i": "EC:3.5.1.8", "l": "\"formylaspartate deformylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877884", "l": "RUNX1 and FOXP3 stimulate the RSPO3 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454916", "l": "The ABCC family mediates organic anion transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050159", "l": "orsellinate decarboxylase activity", "d": ["Catalysis of the reaction: o-orsellinate + H+ = CO2 + orcinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63132", "l": "apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin = cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50831", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 <=> (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167427", "l": "Opioid dissociates from MOR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28658", "l": "glutathione S,S-dioxide + H2O <=> glutathione + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418200", "l": "SRC-1 bound to ARRB2 is not activated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.13", "l": "\"protein kinase C\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62335", "l": "ADP + ATP <=> adenosine 3'-diphosphate,5'-diphosphate + AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53796", "l": "deoxycholoyl-CoA + ursodeoxycholate = deoxycholate + ursodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.14", "l": "\"2-dehydro-3-deoxy-phosphogluconate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15484", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40635", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3134954", "l": "DHX9 binds DNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952101", "l": "p14-ARF transcription is stimulated by RUNX proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757688", "l": "SERPINA6 binds PREDN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002953", "l": "5'-deoxynucleotidase activity", "d": ["Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848829", "l": "CBL autoubiquitinates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050149", "l": "o-aminophenol oxidase activity", "d": ["Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879222", "l": "MDP:NLRP1 binds ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034042", "l": "5-formyluracil DNA N-glycosylase activity", "d": ["Catalysis of the removal of 5-formyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75081", "l": "Formation of AT-AC B Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005018", "l": "platelet-derived growth factor alpha-receptor activity", "d": ["Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16040", "l": "phosphate + thymidine <=> 2-deoxy-alpha-D-ribose 1-phosphate + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162092", "l": "carbovir monophosphate + ATP => carbovir diphosphate + ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018774", "l": "RHOBTB1 binds GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16381", "l": "L-arabinitol + NAD(+) = H(+) + L-xylulose + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.12", "l": "\"L-arabinitol 4-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19024", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine <=> an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74050", "l": "L-alanine(in) + L-valine(out) <=> L-alanine(out) + L-valine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332236", "l": "CBL neddylates TGFBR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109857", "l": "MAP2K1 binds MAPK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36494", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA <=> (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36480", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA => (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.56", "l": "\"caspase-3\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21747", "l": "S-adenosyl-L-methionine <=> 1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71383", "l": "L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56650", "l": "3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH => 3-oxochol-4-en-24-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0043425", "l": "bHLH transcription factor binding", "d": ["Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016750", "l": "O-succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28925", "l": "H(+)(out) + L-phenylalanine(out) => H(+)(in) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033735", "l": "aspartate dehydrogenase activity", "d": ["Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73494", "l": "Co(2+)(out) + 2 hydrogencarbonate(out) <=> Co(2+)(in) + 2 hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.9.-.-", "l": "\"Transferring selenium-containing groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61499", "l": "an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose <=> an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31797", "l": "(+)-caryolan-1-ol => (+)-(E)-beta-caryophyllene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42606", "l": "(9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+) => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110322", "l": "Formation of Pol zeta complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63071", "l": "acetyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 2 CO2 + 3 CoA + triacetate lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247836", "l": "Retromer recycles WLS to the Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534388", "l": "Progesterone Activation Of CatSper (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68674", "l": "16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25227", "l": "H(+) + L-arabinose + NADH => L-arabinitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48251", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) <=> CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58939", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH <=> all-trans-lycopaoctaene + 2 diphosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451895", "l": "IL2RG binds JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28671", "l": "2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.44", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51834", "l": "AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351948", "l": "Mitochondrial recruitment of Drp1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71967", "l": "(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) = (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73001", "l": "L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide] => H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917696", "l": "Cargo Sequestration (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602454", "l": "proMMP9 binds TIMP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19694", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) => 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950718", "l": "Expression of TCP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59953", "l": "2,6-dimethylheptanoyl-CoA + H2O => 2,6-dimethylheptanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46837", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40523", "l": "a quinone + succinate = a quinol + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161567", "l": "LTB4 is oxidised to 12-oxoLTB4 by PTGR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63941", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 => 2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004451", "l": "isocitrate lyase activity", "d": ["Catalysis of the reaction: isocitrate = glyoxylate + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3662344", "l": "Defective HEXB does not cleave the terminal GalNAc from DS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34594", "l": "Co-precorrin-7 + S-adenosyl-L-methionine <=> Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047528", "l": "2,3-dihydroxyindole 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxyindole + O2 = anthranilate + CO2 + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160072", "l": "ubiquitin ligase complex scaffold activity", "d": ["The binding activity of a molecule that brings together an ubiquitin ligase and an ubiquitin ligase-substrate adaptor, permitting those molecules to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69878", "l": "6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68508", "l": "(2E,6E)-farnesyl diphosphate = (Z)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708497", "l": "BACH1 gene produces BACH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69215", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ATP + L-glutamate <=> (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35026", "l": "hydroquinone O-beta-D-glucopyranoside(out) <=> hydroquinone O-beta-D-glucopyranoside(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001083", "l": "alpha-D-glucan binding", "d": ["Binding to alpha-D-glucan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052901", "l": "spermine:oxygen oxidoreductase (spermidine-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050390", "l": "valine decarboxylase activity", "d": ["Catalysis of the reaction: L-valine + H+ = 2-methylpropanamine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047678", "l": "arginine 2-monooxygenase activity", "d": ["Catalysis of the reaction: L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29176", "l": "2 O2 + ubiquinol-8 => 2 H(+) + 2 superoxide + ubiquinone-8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40077", "l": "futalosine + NH4(+) => 6-amino-6-deoxyfutalosine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41510", "l": "H2O + N(5)-hydroxy-L-ornithine + NADP(+) => L-ornithine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49066", "l": "calcitetrol + H2O + 2 oxidized [adrenodoxin] => 2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71249", "l": "beta-alanine(in) + chloride(in) + 2 Na(+)(in) => beta-alanine(out) + chloride(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27670", "l": "1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47930", "l": "(2S)-3-sulfolactate + 2 H(+) + NADPH => (2S)-3-sulfolactaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24552", "l": "5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043768", "l": "S-ribosylhomocysteine lyase activity", "d": ["Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16331", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602984", "l": "Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682388", "l": "Autophagosome maturation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57157", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 => 4-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25262", "l": "2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15584", "l": "biochanin A 7-O-beta-D-glucoside + malonyl-CoA <=> biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187261", "l": "COLEC12 (SCARA4) binds ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538835", "l": "PER binds to DCO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54157", "l": "2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 => [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40882", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66640", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + koraiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16318", "l": "(S)-indan-1-ol + NAD(+) => H(+) + indan-1-one + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34988", "l": "(S)-lactate(in) => (S)-lactate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39276", "l": "(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH => (15Z)-tetracosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71303", "l": "RPE dimers isomerise RU5P to XY5P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54609", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65422", "l": "GMP(out) + NAD(+)(in) => GMP(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74052", "l": "D-threonine(out) + L-alanine(in) => D-threonine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195378", "l": "Homodimerization of VEGF proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67132", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH = (1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36879", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.207", "l": "\"tRNA (cytidine(34)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016643", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."], "t": []}, {"i": "EC:1.4.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52087", "l": "13-octadecanoyloxy-octadecanoate + H2O <=> 13-hydroxy-octadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75807", "l": "Na(+)(out) + propanoate(out) = Na(+)(in) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.103234640867726", "identifiers": [{"i": "GO:0008094", "l": "ATP-dependent activity, acting on DNA", "d": ["Catalytic activity that acts to modify DNA, driven by ATP hydrolysis."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68630", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit] => phycoerythrobilin-L-cysteinyl(48)/L-cysteinyl(59)-[C-phycoerythrin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875451", "l": "MET phosphorylates CBL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375151", "l": "Interaction of NCAM1 with collagens (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70130", "l": "3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710254", "l": "GSDME oligomerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20045", "l": "3-oxopropanoate + H2O + NAD(+) = 2 H(+) + malonate + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61267", "l": "H2O + L-alanine + O2 <=> H2O2 + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59971", "l": "L-threonyl-[protein] + octanoyl-CoA <=> CoA + O-octanoyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.145607380047934", "identifiers": [{"i": "GO:0140994", "l": "RNA polymerase II CTD heptapeptide repeat modifying activity", "d": ["A catalytic activity that acts on the RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS). Reversible modifications cof the RNA polymerase II CTD repeats contribute to regulation of RNA polymerase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17312", "l": "a phenyl acetate + H2O <=> a phenol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18198", "l": "N-cyclohexylformamide => cyclohexyl isocyanide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299297", "l": "Activation of THIK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70682", "l": "glycine betaine(in) + H(+)(in) <=> glycine betaine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990808", "l": "F-bar domain binding", "d": ["Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754130", "l": "CDK4 inhibitors bind CDK4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317530", "l": "SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102706", "l": "butein:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 = aureusidin 6-O-beta-glucoside + H2O + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32880", "l": "(1R,4R,5R)-5-hydroxycamphor + NAD(+) => (1R,4R)-bornane-2,5-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41887", "l": "dodecanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10285", "l": "L-leucine => (3R)-beta-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47537", "l": "3-oxochenodeoxycholate + H(+) + NADPH => isochenodeoxycholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13425", "l": "a pyrimidine ribonucleoside 5'-phosphate + H2O = a pyrimidine nucleobase + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57092", "l": "AH2 + S-(methylsulfanyl)glutathione = A + glutathione + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602458", "l": "Activation of proMMP10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3200023", "l": "Phosphorylated ETS1 binds p16INK4A promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3095889", "l": "MMACHC dealkylates RCbl (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682377", "l": "LC3 de-lipidation by ATG4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70177", "l": "alpha-D-glucose 1-phosphate + D-galactose => beta-D-glucosyl-(1->4)-D-galactose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250272", "l": "TXNIP binds NLRP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948027", "l": "RNASEs bind bacterial phospholipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004918", "l": "interleukin-8 receptor activity", "d": ["Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796077", "l": "AcK-NFE2L2 binds the ABCC1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030744", "l": "luteolin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976716", "l": "NOTCH2 coactivator complex binds HES1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68725", "l": "26-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 26-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0004549", "l": "tRNA-specific ribonuclease activity", "d": ["Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21899", "l": "(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP <=> adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879459", "l": "F-actin capping protein is a heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9864415", "l": "AAC1 imports a proton (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77786", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)glycine + O2 <=> 2-dehydro-D-glucose + glycine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47296", "l": "dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37762", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23159", "l": "(E)-(indol-3-yl)acetaldehyde oxime <=> (indol-3-yl)acetonitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29013", "l": "2-oxoglutarate(out) + H(+)(out) => 2-oxoglutarate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57800", "l": "2,3-dinitrotoluene + NADH + O2 = 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2317314", "l": "AKT binds PDPK1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749505", "l": "LRRC14 binds IKBKB and CHUK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9656947", "l": "OGG1beta translocates to mitochondria (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37329", "l": "ADP + H(+) + L-methionyl-L-alanine(in) + phosphate => ATP + H2O + L-methionyl-L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795460", "l": "SGK1 phosphorylates MDM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42465", "l": "biphenyl-2,2',3-triol + O2 => 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75617", "l": "ectocarpin B + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794444", "l": "ALB binds Cipro (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46705", "l": "ATP + H(+) + salicylate => 2-hydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446077", "l": "BP230 interacts with keretin K5/K14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32114", "l": "S-adenosyl-L-methionine + trans-resveratrol <=> 3-methoxy-4',5-dihydroxy-trans-stilbene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57416", "l": "H2O + L-asparaginyl-[protein] = L-aspartyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48721", "l": "aurachin B + H2O + NAD(+) => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749197", "l": "ORC1 binds to H4K20me2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15455", "l": "H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050080", "l": "malonyl-CoA decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661425", "l": "BIL:ALB dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654224", "l": "Activated FGFR3 binds PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28022", "l": "ATP + holo-[ACP] + octanoate = AMP + diphosphate + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938251", "l": "CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354077", "l": "Integrin alphaIIb beta3 activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76192", "l": "carnosine(out) + 2 H(+)(out) => carnosine(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.434", "l": "\"2-dehydro-3-deoxy-L-fuconate 4-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34620", "l": "1-deoxypentalenate + 2-oxoglutarate + O2 => 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72451", "l": "a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out) = a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50582", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.8", "l": "\"T4 deoxyribonuclease II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73712", "l": "ATP(in) + UTP(out) => ATP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.38", "l": "\"coagulation factor XIIa\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014467", "l": "RHOG binds effectors at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40823", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433981", "l": "Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TICAM1:TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72418", "l": "Li(+)(in) + Na(+)(out) <=> Li(+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77391", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6S-D-GlcNAc + CMP-N-acetyl-beta-neuraminate = alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6S-D-GlcNAc + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77919", "l": "a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA + H2O = 2-deoxy-D-ribose 5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.153", "l": "\"fructan beta-(2,1)-fructosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047288", "l": "beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase", "d": ["Catalysis of the reaction: beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71966", "l": "(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) <=> (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59143", "l": "ATP + citrate + N(5)-[(S)-citryl]-D-ornithine <=> AMP + diphosphate + H(+) + staphyloferrin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045029", "l": "G protein-coupled UDP receptor activity", "d": ["Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23900", "l": "cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34276", "l": "2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine => 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16616", "l": "acetyl-CoA + an arylamine <=> an N-acetylarylamine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5676229", "l": "WIPIs bind PI3P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757686", "l": "SERPINA6 binds PREDL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63474", "l": "ADP + all-trans-hexaprenyl phosphate + H(+) => all-trans-hexaprenol + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814132", "l": "GDPD5 hydrolyzes GPCho (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033478", "l": "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50084", "l": "ATP + H2O + taurolithocholate 3-sulfate(in) = ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35176", "l": "novobiocin(in) => novobiocin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193703", "l": "IKKbeta is activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47948", "l": "H2O + thiamine phosphate = phosphate + thiamine", "d": [], "t": []}, {"i": "EC:3.1.3.100", "l": "\"thiamine phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37716", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46393", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71820", "l": "L-thyroxine(out) => L-thyroxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46735", "l": "(2R,6)-dimethylheptanoyl-CoA <=> (2S,6)-dimethylheptanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53188", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15650", "l": "carbamate + 2 H(+) => CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20993", "l": "16-hydroxytabersonine + S-adenosyl-L-methionine => 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109857", "l": "MAP2K1 binds MAPK3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51656", "l": "keto-D-tagaturonate = keto-D-fructuronate", "d": [], "t": []}, {"i": "EC:5.1.2.7", "l": "\"tagaturonate epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40572", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22097", "l": "phosphate + RNA(n+1) => a ribonucleoside 5'-diphosphate + RNA(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17688", "l": "H(+) + uracil 5-carboxylate <=> CO2 + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732692", "l": "Triazenes produce DNA damage in the form of O6-methylguanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428752", "l": "Dissociation of the TP:Gq complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22375", "l": "H2O + O2 + propionate 3-nitronate <=> 3-oxopropanoate + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25485", "l": "(2E)-geranyl diphosphate => (1S,4R)-camphene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41955", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.8", "l": "\"Fas-activated serine/threonine kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17941", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.99", "l": "\"2-methylisocitrate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51308", "l": "H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50629", "l": "a 2-(omega-methylsulfanyl)alkylmalate => a 3-(omega-methylsulfanyl)alkylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57193", "l": "H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] => glycolate + H(+) + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51493", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33237", "l": "3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+) => 2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035034", "l": "histone acetyltransferase regulator activity", "d": ["Binds to and modulates the activity of histone acetyltransferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28341", "l": "(R)-carnitinyl-CoA <=> crotonobetainyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12071", "l": "apo-[ACP] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34180", "l": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide => D-glucuronate + H(+) + mycophenolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51344", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211716", "l": "Rho GTPase-activating protein 10 (RHG10) interacts with caspase-activated PAK-2p34 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43233", "l": "H2O + isatin => H(+) + isatinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50516", "l": "acetyl-CoA + N-terminal L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26011", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) => 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57350", "l": "3-hydroxy-4-methylanthranilate + H(+) + L-alanine => 3-hydroxy-4-methyl-L-kynurenine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57438", "l": "acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => guaethol + O2 + reduced [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011975", "l": "Estrogen-responsive MYC gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212614", "l": "Glutamine transport from astrocytes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63329", "l": "2-(9Z-octadecenoyl)-glycerol + ATP => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12107", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP <=> 7,8-dihydrofolate + dTMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37941", "l": "(8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75041", "l": "acetyl-CoA(out) => acetyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798748", "l": "Exocytosis of secretory granule lumen proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17591", "l": "H(+) + L-alanine + NADH + pyruvate => 2,2'-iminodipropanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77207", "l": "3'-phosphoadenylyl sulfate + glycodeoxycholate = 3alpha-sulfoglycodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008847", "l": "Enterobacter ribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433808", "l": "viral dsRNA: TLR3: TICAM1 recruits TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9716913", "l": "ESR1 binds ESR1 antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603445", "l": "Activated NTRK3 stimulates PI3K activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191654", "l": "c-src associates with Cx43 in gap junctions (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848392", "l": "IL18BP binds IL18 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66935", "l": "(E)-4-coumaroyl-CoA + 5-hydroxyanthranilate <=> avenanthramide A + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047618", "l": "acylagmatine amidase activity", "d": ["Catalysis of the reaction: N(4)-benzoylagmatine + H2O = agmatine + benzoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69843", "l": "a 5,6-dihydrouridine in RNA + NAD(+) = a uridine in RNA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354060", "l": "Translocation of RIAM to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50655", "l": "2-(3-methylsulfanyl)propylmalate <=> 2-(2-methylsulfanyl)propylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13059", "l": "an N-acylneuraminate + phosphate => an N-acylneuraminate 9-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199131", "l": "PVR binds CD226 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038200", "l": "ethylene receptor histidine kinase activity", "d": ["Combining with ethylene and transmitting the signal within the cell to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.145607380047934", "identifiers": [{"i": "GO:0004407", "l": "histone deacetylase activity", "d": ["Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41656", "l": "dihydrosanguinarine + NADP(+) = NADPH + sanguinarine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41931", "l": "(2E)-octadecenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + octadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50460", "l": "a medium chain fatty acid + ATP + holo-[ACP] = a medium-chain fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.47", "l": "\"medium-chain-fatty-acid--[acyl-carrier-protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22964", "l": "H(+) + L-ornithine = CO2 + putrescine", "d": [], "t": []}, {"i": "EC:4.1.1.17", "l": "\"ornithine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507875", "l": "Aquaporins passively transport urea into cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35044", "l": "N-(4-aminobenzoyl)-L-glutamate(in) => N-(4-aminobenzoyl)-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69217", "l": "(omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+) => (omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180573", "l": "Degradation of ubiquitinated CD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54126", "l": "CO2 + excited coelenteramide h monoanion + H(+) => coelenterazine h dioxetanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798749", "l": "Exocytosis of specific granule lumen proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888589", "l": "Release of GABA at the synapse (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210292", "l": "Interaction of DAP12 and TREM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047107", "l": "gamma-guanidinobutyraldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-guanidinobutanal + H2O + NAD+ = 4-guanidinobutanoate + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174171", "l": "Association of Cyclin A with the APC/C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59179", "l": "ADP + L-serine <=> AMP + H(+) + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018681", "l": "deisopropylatrazine monooxygenase activity", "d": ["Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 acetaldehyde + 2 deisopropyldeethylatrazine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951500", "l": "Dissociation of CANX from nonameric complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0050509", "l": "N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209840", "l": "Two DITs combine to form thyroxine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21442", "l": "a long-chain alkane + formate + H2O + 2 NADP(+) => a long-chain fatty aldehyde + H(+) + 2 NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665703", "l": "ERBB2 TMD/JMD mutants bind pertuzumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72476", "l": "cis-aconitate(in) + citrate(out) => cis-aconitate(out) + citrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357472", "l": "PAK1-3 autophosphorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017084", "l": "delta1-pyrroline-5-carboxylate synthetase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183126", "l": "Factor B binds to surface-associated C3b (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71490", "l": "H2O + Leu-enkephalin <=> L-phenylalanyl-L-leucine + L-tyrosylglycylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35838", "l": "2'-dehydrokanamycin A + H(+) + NADPH <=> kanamycin A + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805479", "l": "TP53RK phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59049", "l": "D-ornithine + H(+) => CO2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74723", "l": "Endosome acidification (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13003", "l": "1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47926", "l": "(2S)-3-sulfolactaldehyde + pyruvate => 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10706", "l": "AMP + diphosphate + L-valyl-tRNA(Val) => ATP + L-valine + tRNA(Val)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928607", "l": "p-EPHs bind VAV2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045301", "l": "tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity", "d": ["Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36247", "l": "(E)-anol + S-adenosyl-L-methionine = (E)-anethole + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57082", "l": "1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione => glutathione + S-methyl-1-thio-D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617182", "l": "PRKACA phosphorylates PLN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17579", "l": "ADP-L-glycero-beta-D-manno-heptose => ADP-D-glycero-beta-D-manno-heptose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693356", "l": "CEMIP hydrolyses HA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749197", "l": "ORC1 binds to H4K20me2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046875", "l": "ephrin receptor binding", "d": ["Binding to an ephrin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74683", "l": "2 AH2 + 2 archaeol + 4 S-adenosyl-L-methionine = 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether + 4 H(+) + 4 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18064", "l": "5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran <=> methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43707", "l": "ATP + H(+) + tetradecanoate <=> diphosphate + tetradecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19664", "l": "D-mannitol 1-phosphate + NAD(+) <=> beta-D-fructose 6-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54992", "l": "3 A + FMN + H2O + L-glutamate + O2 = 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+)", "d": [], "t": []}, {"i": "EC:2.6.1.114", "l": "\"8-demethyl-8-aminoriboflavin-5'-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31868", "l": "(S)-2,3-epoxysqualene => baccharis oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36499", "l": "2-dehydro-3-deoxy-L-rhamnonate + NAD(+) = 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.401", "l": "\"2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72018", "l": "acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine <=> 2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41168", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62528", "l": "digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigoxin + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16420", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) <=> H(+) + L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50986", "l": "prostaglandin E2(in) => prostaglandin E2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23524", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol = an alkyl cinnamate + beta-D-glucose", "d": [], "t": []}, {"i": "EC:2.3.1.152", "l": "\"alcohol O-cinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40338", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050555", "l": "2-hydroxypropyl-CoM lyase activity", "d": ["Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0032038", "l": "myosin II heavy chain binding", "d": ["Binding to a heavy chain of a myosin II complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49831", "l": "(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31623", "l": "L-olivosyl-oleandolide + S-adenosyl-L-methionine = H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.239", "l": "\"L-olivosyl-oleandolide 3-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102533", "l": "genkwanin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: genkwanin + S-adenosyl-L-methionine = H+ + apigenin-7,4'-dimethyl ether + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610270", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN3A (GRIN3A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40953", "l": "acetate + L-2,4-diaminobutanoate => (2S)-2-acetamido-4-aminobutanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21281", "l": "H2O + 2 O2 + thiamine => H(+) + 2 H2O2 + thiamine acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37314", "l": "ATP + glycyl-L-glutamine(out) + H2O <=> ADP + glycyl-L-glutamine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20376", "l": "ATP + CoA + propanoate <=> AMP + diphosphate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46804", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine = a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.317", "l": "\"sphingolipid C(9)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944454", "l": "mTORC1 phosphorylates MAF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3858482", "l": "DVL is recruited to the receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14951", "l": "2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2 => A + H2O + quinoline-4-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13244", "l": "ATP + L-fucose <=> ADP + beta-L-fucose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68329", "l": "(R)-4'-phosphopantetheine + H2O => (R)-pantetheine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209081", "l": "Disassembly of the destabilised 'destruction complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909720", "l": "IFN alpha/beta binds to IFNAR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25734", "l": "H(+) + N,N-dihydroxy-L-tetrahomomethionine <=> (E)-7-(methylsulfanyl)heptanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42335", "l": "ATP + L-glutamate + oxidized coenzyme F420-2 <=> ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21552", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10277", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) => 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618093", "l": "ATP hydrolysis by HSP90 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15716", "l": "a beta-D-galactoside + acetyl-CoA <=> a 6-acetyl-beta-D-galactoside + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62401", "l": "(1R,2S)-ephedrine + NAD(+) => (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038036", "l": "sphingosine-1-phosphate receptor activity", "d": ["Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696268", "l": "RND3 binds effectors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19713", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.15", "l": "\"arachidonate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805740", "l": "SETD8 methylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25708", "l": "(E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-dihomomethionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69193", "l": "ATP + L-glutamate + L-glutamyl-[tubulin] => ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33485", "l": "CoA + ergosteryl ester => an acyl-CoA + ergosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28934", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate <=> 4-carboxy-2-hydroxy-cis,cis-muconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202724", "l": "P-selectin binds P-selectin ligand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60361", "l": "FMN + H(+) + oxidized coenzyme F420-0 => dehydro coenzyme F420-0 + FMNH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40831", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60070", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.-", "l": "\"Pentosyltransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29345", "l": "L-aspartate(out) + succinate(in) => L-aspartate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32945", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390598", "l": "Myosin Binds ATP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49166", "l": "5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine => a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9824888", "l": "OPTN, TBK1 bind ubiquitinated MOM proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2002460", "l": "P4HB binds Collagen chains (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352059", "l": "SLC6A15-mediated amino acid uptake (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76999", "l": "H(+) + NAD(+) + reduced [4Fe-4S]/[3Fe-4S]-[ferredoxin] = NADH + oxidized [4Fe-4S]/[3Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950362", "l": "EBI3:CANX binds IL12A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67201", "l": "H2O + N-acetyltyramine => acetate + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23575", "l": "3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + phlorisovalerophenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35170", "l": "minocycline(in) <=> minocycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39610", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH <=> (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59101", "l": "diglucosyl-enterobactin + UDP-alpha-D-glucose => H(+) + triglucosyl-enterobactin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29476", "l": "(2E,6E)-farnesyl diphosphate => (+)-cubenene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.20", "l": "\"cathepsin G\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983150", "l": "Proteasomal cleavage of substrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71164", "l": "HGD dioxygenates homogentisate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102768", "l": "anthocyanidin synthase activity", "d": ["Catalysis of the reaction: flavan-3,3',4,4',5,5',7-heptol + O2 + 2-oxoglutarate = H+ + delphinidin + 2 H2O + carbon dioxide + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11577", "l": "ATP + thiamine => AMP + H(+) + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34874", "l": "methanol(out) <=> methanol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44380", "l": "a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.79", "l": "\"arogenate dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54661", "l": "an aromatic (S)-hydroxynitrile => an aromatic aldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607733", "l": "BCL10 binds CARD9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864569", "l": "WWOX binds TFAP2C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.26", "l": "\"rhodotorulapepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173631", "l": "Activation of C1s (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23540", "l": "ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)", "d": [], "t": []}, {"i": "EC:6.1.1.17", "l": "\"glutamate--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40299", "l": "6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.35", "l": "\"6-deoxyerythronolide B hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947499", "l": "Exchange of oxygen with sulfur in MoCo (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9824977", "l": "MAPK1-dependent phosphorylation of MITF-M (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78704", "l": "4-(hydroxy(methyl)phosphoryl)-2-oxobutanoate + L-glutamate => 2-oxoglutarate + L-phosphinothricin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936665", "l": "OPS is added to the carrier sulfide (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687107", "l": "MAPK4,6 translocate to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12766", "l": "CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate => acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10816", "l": "H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside", "d": [], "t": []}, {"i": "EC:3.2.1.63", "l": "\"1,2-alpha-L-fucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102963", "l": "(S)-corytuberine synthase activity", "d": ["Catalysis of the reaction: H+ + (S)-reticulinium(1+) + NADPH + O2 = (S)-corytuberine + NADP + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050332", "l": "thiamine pyridinylase activity", "d": ["Catalysis of the reaction: pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052879", "l": "9,12-octadecadienoate 8-hydroperoxide 8S-isomerase activity", "d": ["Catalysis of the reaction: (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28133", "l": "baicalin + H2O <=> baicalein + D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47970", "l": "a ganglioside GM3 + N-acetyl-beta-D-galactosamine => a ganglioside GM2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625197", "l": "GFAP binds LAMP2a multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29205", "l": "dimethyl sulfide + H2O + menaquinone-8 => dimethyl sulfoxide + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65140", "l": "AH2 + O2 + protoaustinoid A = A + berkeleyone A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018773", "l": "acetylpyruvate hydrolase activity", "d": ["Catalysis of the reaction: acetylpyruvate + H2O = acetate + H+ + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78770", "l": "3''-dehydroorientin <=> 1,5-anhydro-D-erythro-hex-1-en-3-ulose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17757", "l": "H(+) + L-methionine = 3-(methylsulfanyl)propanamine + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.57", "l": "\"methionine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848110", "l": "SOCS3 binds activated PTK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349626", "l": "Integrin alpha2beta1 binds laminin-332 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964619", "l": "PAK1 binds ARHGEF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682967", "l": "WHSC1 binds DNA DSBs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21594", "l": "H(+) + L-2-aminopentanoate + NADH + pyruvate => (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31216", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) => (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56271", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> CMP + H(+) + N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106363", "l": "protein-cysteine methyltransferase activity", "d": ["Catalysis of the reaction: L-cysteinyl-[protein] + S-adenosyl-L-methionine = H+ + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]."], "t": []}, {"i": "RHEA:66544", "l": "L-cysteinyl-[protein] + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23980", "l": "cyclomaltodextrin + H2O = linear maltodextrin", "d": [], "t": []}, {"i": "EC:3.2.1.54", "l": "\"cyclomaltodextrinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56275", "l": "4 Fe(III)-[cytochrome cL] + H2O + methanol <=> 4 Fe(II)-[cytochrome cL] + formate + 5 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56711", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65908", "l": "3-hydroxy-L-kynurenine + pyruvate = H2O + L-alanine + xanthurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0055103", "l": "ligase regulator activity", "d": ["Binds to and modulates the activity of a ligase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54693", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (13E)-labda-7,13-dien-15-yl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78927", "l": "a very-long-chain (3S)-hydroxyacyl-CoA + NAD(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75782", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoate + H2O <=> (10S)-hydroxy-(6Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16978", "l": "acetoacetate + coenzyme M + NADP(+) => 2-oxopropyl-coenzyme M + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733969", "l": "Bile salts dissociate from FABP6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.88", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437230", "l": "L1-FGFR cis-heterodimerization (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61380", "l": "2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O = 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210439", "l": "glutamate uptake by astrocytes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17713", "l": "(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine", "d": [], "t": []}, {"i": "EC:1.14.19.67", "l": "\"salutaridine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45307", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381091", "l": "IRE1 dimer autophosphorylates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782296", "l": "DUS2:EPRS reduces uridine to dihydrouridine in tRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669863", "l": "Masitinib-resistant KIT mutants do not bind masitinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27347", "l": "5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+) => FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76355", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(out) = n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2471842", "l": "Collagen type XXV ectomain shedding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48311", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O <=> (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72556", "l": "estrone 3-sulfate(out) + propanoate(in) => estrone 3-sulfate(in) + propanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60999", "l": "H2O + L-leucine + O2 <=> 4-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913446", "l": "Interleukin-5 is a homodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430311", "l": "Rsu-1 interacts with Pinch1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694522", "l": "Inner coat assembly and cargo binding (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55464", "l": "11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] = 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936851", "l": "AHRR binds ARNT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29970", "l": "2'-deoxyuridine(in) + H(+)(in) <=> 2'-deoxyuridine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008705", "l": "methionine synthase activity", "d": ["Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198756", "l": "ERK1/2 phosphorylates MSK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56195", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11511", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 <=> 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44632", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + O2 = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.80", "l": "\"(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.13", "l": "\"iduronate-2-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080025", "l": "phosphatidylinositol-3,5-bisphosphate binding", "d": ["Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20314", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP => 1D-myo-inositol hexakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983158", "l": "Trimming of peptides in ER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62733", "l": "(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) => (+)-isomalbrancheamide D + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-901047", "l": "Binding of ERp57 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19236", "l": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] <=> H(+) + hexadecanoate + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29507", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-gurjunene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.72", "l": "\"alpha-gurjunene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042286", "l": "glutamate-1-semialdehyde 2,1-aminomutase activity", "d": ["Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21676", "l": "2 dimethylallyl diphosphate = (R)-lavandulyl diphosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.69", "l": "\"lavandulyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15910", "l": "2-oxoglutarate + O2 + taurine => aminoacetaldehyde + CO2 + H(+) + succinate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27401", "l": "2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate", "d": [], "t": []}, {"i": "EC:5.99.1.4", "l": "\"2-hydroxychromene-2-carboxylate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21284", "l": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14477", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.7", "l": "\"medium-chain acyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69385", "l": "(R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) => (3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28124", "l": "ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+) => ATP + di-trans,octa-cis-undecaprenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77037", "l": "H(+) + heptan-2-one + NADH + NH4(+) => (2S)-heptan-2-amine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19012", "l": "a 3-acylpyruvate + H2O <=> a carboxylate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43222", "l": "H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28104", "l": "D-mannose + GDP + H(+) => GDP-alpha-D-mannose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67668", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55064", "l": "4-methylpentanoyl-CoA + H2O = 4-methylpentanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31956", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25786", "l": "(S)-lactaldehyde + pyruvate => 2-dehydro-3-deoxy-L-rhamnonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985201", "l": "ABCE1 binds RNASEL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5627072", "l": "RHOQ binds GOPC:CFTR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46740", "l": "7-dehydrodesmosterol + H(+) + NADPH = desmosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13970", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + GTP => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49605", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) => 2-glutathionyl-2-methylbut-3-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52248", "l": "6 H2O + 4 Mn(3+) + O2 = 12 H(+) + 4 MnO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13557", "l": "ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.3", "l": "\"glutathione synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665761", "l": "FMNL3 binds RHOC:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668605", "l": "RAC2:GTP binds NOX2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52855", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] <=> 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33280", "l": "L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707683", "l": "PGRMC2 binds Hemes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694377", "l": "pp1a cleaves itself (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653974", "l": "Ragulator binds Rag dimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34345", "l": "4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone => (20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56872", "l": "(S)-N-acetyl-1-phenylethylamine + H2O = (S)-1-phenylethylamine + acetate", "d": [], "t": []}, {"i": "EC:3.5.1.85", "l": "\"(S)-N-acetyl-1-phenylethylamine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183072", "l": "EGFR non-clathrin mediated endocytosis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72392", "l": "2 hydrogencarbonate(out) + oxalate(in) => 2 hydrogencarbonate(in) + oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201603", "l": "Caspase-mediated cleavage of PKC theta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73048", "l": "guanidinoacetate(in) => guanidinoacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54777", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine => [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014449", "l": "RHOG binds effectors at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17351", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate => (2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18556", "l": "(2R,3S)-tartrate + NAD(+) <=> dihydroxyfumarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63401", "l": "Fe(II)-hydroxyheme i => Fe(II)-heme a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2545196", "l": "FN1 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15197", "l": "a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.72", "l": "\"site-specific DNA-methyltransferase (adenine-specific)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66893", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033961", "l": "cis-stilbene-oxide hydrolase activity", "d": ["Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40974", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018557", "l": "1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350058", "l": "Formation of CSL NCOR corepressor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373722", "l": "Nephrin binds CASK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24022", "l": "fumarate + L-arginine => 2-(N(omega)-L-arginino)succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49832", "l": "a fatty aldehyde + H2O + NAD(+) = a fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632892", "l": "TP53 stimulates transcription of RRM2B gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989776", "l": "Expression of APOA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.19", "l": "\"prokaryotic ubiquitin-like protein ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734713", "l": "ORC6 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070287", "l": "ferritin receptor activity", "d": ["Combining with ferritin, and delivering ferritin into the cell via endocytosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3240957", "l": "Formation of PRC2-EZH2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35946", "l": "brevianamide F + dimethylallyl diphosphate <=> deoxybrevianamide E + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10742", "l": "a ketone + H(+) + NADH => a secondary alcohol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797553", "l": "Protein 4.1 binds CASK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32871", "l": "a 2-acylglycerol + H2O = a carboxylate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036243", "l": "succinate-semialdehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374672", "l": "Cis-heterodimerization of L1 and Axonin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73806", "l": "AIR + CO2 => CAIR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018857", "l": "2,4-dichlorobenzoate-CoA ligase activity", "d": ["Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193702", "l": "Part of the ICD migrates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12613", "l": "2 glutathione + L-cystine = glutathione disulfide + 2 L-cysteine", "d": [], "t": []}, {"i": "EC:1.8.4.4", "l": "\"glutathione--cystine transhydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213246", "l": "Disassociation of CLIP from MHC II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73968", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75810", "l": "Na(+)(out) + propanoate(out) <=> Na(+)(in) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203946", "l": "PDK isozymes phosphorylate PDHC subunit E1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140486", "l": "zinc ion sequestering activity", "d": ["Binding to a zinc ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73658", "l": "(S)-nicotine + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + N-methylmyosmine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004473", "l": "malate dehydrogenase (decarboxylating) (NADP+) activity", "d": ["Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9854961", "l": "SDHAF4 binds to FAD-SDHA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65428", "l": "deamido-NAD(+)(in) + NAD(+)(out) = deamido-NAD(+)(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416683", "l": "SEMA3E binds to PLXND1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016490", "l": "structural constituent of peritrophic membrane", "d": ["The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27272", "l": "H(+) + hexadecanoyl-CoA + NADPH => CoA + hexadecanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620103", "l": "ALDH2 transforms GTN to NO (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015042", "l": "trypanothione-disulfide reductase (NADPH) activity", "d": ["Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850786", "l": "SPINK6 binds KLK12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103011", "l": "mannosylfructose-phosphate synthase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + beta-D-fructofuranose 6-phosphate = mannosylfructose-phosphate + GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928620", "l": "PAK1 autophosphorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43624", "l": "2-aminomalonate semialdehyde + H(+) = aminoacetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018862", "l": "phenylphosphate carboxylase activity", "d": ["Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008145", "l": "phenylalkylamine binding", "d": ["Binding to phenylalkylamine or one of its derivatives."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51111", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628807", "l": "Defective SLC29A3 does not transport nucleosides from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56674", "l": "(E)-4-coumaroyl-CoA + H(+) + NADPH => dihydro-4-coumaroyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48964", "l": "2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770131", "l": "Formation of the Spliceosomal B* complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43811", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977238", "l": "Activated TLR5/TLR15 homodimer recruits MyD88 adaptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888589", "l": "Release of GABA at the synapse (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944218", "l": "Association of procollagen type VIII (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045509", "l": "interleukin-27 receptor activity", "d": ["Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15200", "l": "a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine <=> an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9865630", "l": "Metallochaperone inserts 2Cu2+ into MT-CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49204", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48278", "l": "a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine => H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10159", "l": "dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54083", "l": "5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36821", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA => (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56436", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035497", "l": "cAMP response element binding", "d": ["Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57386", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA => (13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2514831", "l": "Fibrillin-1 degradation by MMP14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051432", "l": "BH1 domain binding", "d": ["Binding to a BH1 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5195402", "l": "CDK1 phosphorylates LPIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33946", "l": "H(+) + 2 L-arginine + 3 NADH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68841", "l": "(2Z,6E)-farnesyl diphosphate => (6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52188", "l": "1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione = (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9825704", "l": "AKT3 phosphorylates TBX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047722", "l": "indolelactate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 3-(indol-3-yl)lactate + NAD+ = 3-(indol-3-yl)pyruvate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805285", "l": "PLK3 phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9692376", "l": "BCL2 binds BCL2 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.111", "l": "\"2-oxoglutaramate amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404144", "l": "Parenchymal atROL translocates to HSCs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50357", "l": "4-hydroxy-6-methylpretetramide + NADPH + O2 => 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30614", "l": "A + all-trans-zeta-carotene <=> AH2 + all-trans-neurosporene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57718", "l": "carbamate + H(+) + H2O => hydrogencarbonate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66967", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose <=> alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.124", "l": "\"2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20811", "l": "acetyl-CoA + N-acetylneuraminate <=> CoA + N-acetyl-7-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24250", "l": "glycine + pyruvate => glyoxylate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36229", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106421", "l": "L-glutamate:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamate(out) + H+(in) = L-glutamate(in) + H+(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977629", "l": "Displacement of C2a/Bb by CR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9698844", "l": "MLKL binds HSP90:CDC37 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46960", "l": "butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.1.109", "l": "\"butanoyl-CoA dehydrogenase complex (NAD(+), ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19618", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948136", "l": "ULK1 Translocates to the mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77865", "l": "2-dehydro-D-glucose + L-phenylalanine => (2S)-3-phenyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72012", "l": "glutathione(in) + urate(out) => glutathione(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102215", "l": "thiocyanate methyltransferase activity", "d": ["Catalysis of the reaction: thiocyanate + S-adenosyl-L-methionine = methyl thiocyanate + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942302", "l": "MMP13 cleaves OPTC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0005549", "l": "odorant binding", "d": ["Binding to an odorant, any substance capable of stimulating the sense of smell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375140", "l": "CDO binds promyogenic cadherins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450027", "l": "Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63680", "l": "(7R,8S)-7,8-diammoniononanoate + CO2 = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34891", "l": "selenite(in) = selenite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71893", "l": "H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide => dGMP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202500", "l": "Activation of IKK complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.-", "l": "\"Acting on ATP; involved in cellular and subcellular movement\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38051", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54413", "l": "a 3-oxo-5beta-steroid + NADP(+) => a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692880", "l": "HRH3 binds Hist (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647980", "l": "mature RAS proteins translocate to plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9857590", "l": "MITF-M-dependent GMPR expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265456", "l": "NPC1L1 binds ezetimibe (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49190", "l": "a 3-vinylbacteriochlorophyllide d + H2O => a bacteriochlorophyllide d", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77787", "l": "an N-(1-deoxy-beta-D-fructopyranos-1-yl)amine + H2O + O2 = 2-dehydro-D-glucose + an aliphatic amine + H2O2", "d": [], "t": []}, {"i": "EC:1.5.3.25", "l": "\"fructosyl amine oxidase (glucosone-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13438", "l": "(E)-cinnamate + UDP-alpha-D-glucose => 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18882", "l": "ATP + histamine + L-glutamate => ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102259", "l": "1,2-diacylglycerol acylhydrolase activity", "d": ["Catalysis of the reaction: H2O + a 1,2-diacyl-sn-glycerol = a monoglyceride + a fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49413", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose => alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73818", "l": "O2 + piceatannol <=> 3,4-dihydroxybenzaldehyde + 3,5-dihydroxybenzaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66006", "l": "Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30516", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + S-methyl-5'-thioadenosine + thermospermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56203", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose <=> H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78327", "l": "D-erythrose 4-phosphate + L-erythrulose = beta-D-fructose 6-phosphate + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57579", "l": "7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68926", "l": "AMP + diphosphate + hexanal + NADP(+) => ATP + H(+) + hexanoate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46209", "l": "ATP + CoA + eicosanoate => AMP + diphosphate + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46005", "l": "2-methylpropanal + CoA + NAD(+) => 2-methylpropanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112609", "l": "POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77321", "l": "5-(3-methylguanidino)-2-oxopentanoate + L-alanine => N(omega)-methyl-L-arginine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944215", "l": "Association of procollagen type XX (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17866", "l": "5,6,7,8-tetrahydropteridine + NADP(+) => 6,7-dihydropteridine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69358", "l": "3-bromo-L-tyrosyl-[protein] + H2O => H(+) + hypobromite + L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948757", "l": "AKT phosphorylates MKRN1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69459", "l": "3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH <=> 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22263", "l": "H2O + triacetate lactone <=> H(+) + triacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1008270", "l": "Activated TAK1 leaves endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549129", "l": "OCT1 transports organic cations into hepatic cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9824582", "l": "MAPK1 phosphorylates SOX10 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132088", "l": "Vitronectin prevents C9 polymerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004117", "l": "calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity", "d": ["Catalysis of the reactions: 3',5'-cyclic AMP + H2O = AMP + H+ and 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin."], "t": []}, {"i": "REACT:R-HSA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26137", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46667", "l": "corticosterone + H(+) + NADPH <=> 5beta-dihydrocorticosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655323", "l": "Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54787", "l": "Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide <=> Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047255", "l": "galactogen 6-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34514", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25688", "l": "L-cysteinyl-tRNA(Cys) + phosphate => H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55341", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecenyl)-glycerol => 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654404", "l": "Activated FGFR2 binds SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36650", "l": "2-hydroxyhexadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5333678", "l": "CPNEs bind PL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353301", "l": "Binding of Pol kappa and REV1 complex to the lesion on the template DNA strand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177922", "l": "EGFR dimerization (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18288", "l": "an N-acyl-D-aspartate + H2O <=> a carboxylate + D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72934", "l": "O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase] <=> atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807565", "l": "GNLY is transferred to the phagosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659989", "l": "Defective TALDO1 does not transform SH7P, GA3P to Fru(6)P, E4P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110319", "l": "Elongation by POLH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351936", "l": "Caspase-mediated cleavage of claspin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901006", "l": "Binding of Malectin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50028", "l": "H2O + tetradecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139906", "l": "Activation of BAD by calcineurin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17967", "l": "(8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73814", "l": "L-proline(in) <=> L-proline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37836", "l": "aklavinone + H(+) + NADPH + O2 => epsilon-rhodomycinone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60165", "l": "a guanosine in RNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23868", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone", "d": [], "t": []}, {"i": "EC:4.1.3.35", "l": "\"(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58545", "l": "2 L-ascorbate + N-tetradecanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43646", "l": "3-oxohexadecanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801109", "l": "CHM binds RGGT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141367", "l": "Myristoylation of tBID by NMT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53403", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44263", "l": "2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA <=> 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37903", "l": "6-hydroxytryprostatin B + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tryprostatin A", "d": [], "t": []}, {"i": "EC:2.1.1.293", "l": "\"6-hydroxytryprostatin B O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419461", "l": "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047590", "l": "5-dehydro-2-deoxygluconokinase activity", "d": ["Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28576", "l": "H(+)(out) + sulfate(out) => H(+)(in) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032551", "l": "pyrimidine ribonucleoside binding", "d": ["Binding to a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47240", "l": "H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69857", "l": "a uridine in mRNA + H(+) + NADPH => a 5,6-dihydrouridine in mRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390909", "l": "HRH2 binds hist (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22290", "l": "an N-acyl-sphingoid base + an oligoglycosyl-(1->4)-D-glucose => an oligoglycosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43867", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418904", "l": "A1 and A3 receptors bind adenosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033422", "l": "CCC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CCC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75228", "l": "H2O + L-xylono-1,4-lactone => H(+) + L-xylonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9702849", "l": "CALCR binds gepants (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34778", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) <=> a 3-oxosteroid + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37720", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251992", "l": "Cleavage of P-ERBB4jmA isoforms by ADAM17 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730483", "l": "SARS-CoV-2 nsp16 binds to U1 snRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40802", "l": "2-methylpropanoyl-CoA + H2O <=> 2-methylpropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73632", "l": "CTP(out) + dGTP(in) => CTP(in) + dGTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709406", "l": "CO binds to Cytochrome c oxidase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140936", "l": "histone H2B deubiquitinase activity", "d": ["A histone deubiquitinase that cleaves ubiquitin from a histone H2B protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112727", "l": "Serine phosphorylation of STATs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035167", "l": "NR1H2,3 binds the EEPD1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60150", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18098", "l": "pteridine-2,4,6,7-tetrol => H(+) + xanthine-8-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0016675", "l": "oxidoreductase activity, acting on a heme group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.9.-.-", "l": "\"Acting on a heme group of donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62458", "l": "diphosphate + L-glutamyl-5'-AMP => ATP + H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58918", "l": "(S)-2,3-epoxysqualene + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61661", "l": "(2E)-geraniol + ATP => (2E)-geranyl phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39255", "l": "(13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42308", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14835", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH => (R)-mevalonate + CoA + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021935", "l": "SST gene expression is stimulated by MECP2 and CREB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18459", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+) => D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42263", "l": "H(+) + heptanoyl-CoA + malonyl-[ACP] <=> 3-oxononanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46274", "l": "(4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030729", "l": "acetoacetate-CoA ligase activity", "d": ["Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20383", "l": "5alpha-androstan-3,17-dione + H(+) + NADH => androsterone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77197", "l": "(2E)-decenoyl-CoA => (3Z)-decenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44802", "l": "2-demethylmenaquinol-6 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-hexaprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948027", "l": "RNASEs bind bacterial phospholipids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42506", "l": "6-acetamido-2-oxohexanoate + L-glutamate => 2-oxoglutarate + N(6)-acetyl-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73945", "l": "FAS-mediated dimerization of procaspase-8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43191", "l": "S-adenosyl-L-methionine + uridine(2634) in 25S rRNA <=> H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58131", "l": "A + O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine <=> AH2 + alstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38763", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045237", "l": "CXCR1 chemokine receptor binding", "d": ["Binding to a CXCR1 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190258", "l": "FGFR2c binds to FGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682826", "l": "LGI1 binds ADAM11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17632", "l": "alpha,alpha-trehalose(in) <=> alpha,alpha-trehalose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64966", "l": "dUMP + 2 H(+) + 2 phosphate => dUTP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762343", "l": "PREDL:ALB dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65976", "l": "7-dehydrocholesterol + hnu = previtamin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047165", "l": "flavonol-3-O-beta-glucoside O-malonyltransferase activity", "d": ["Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50128", "l": "NAD(+) + resolvin D1 = 17-oxoresolvin D1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13798", "l": "a dolichyl phosphate + H2O => di-trans,poly-cis-dolichol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48708", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76331", "l": "L-aspartate(in) + L-tyrosine(out) = L-aspartate(out) + L-tyrosine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65246", "l": "(2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP => (2S)-hesperetin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30620", "l": "2 A + all-trans-zeta-carotene => 2 AH2 + all-trans-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033965", "l": "aculeacin-A deacylase activity", "d": ["Catalysis of the hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140693", "l": "molecular condensate scaffold activity", "d": ["Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112037", "l": "Inactivation of PLC beta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16693", "l": "alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal", "d": [], "t": []}, {"i": "EC:5.5.1.10", "l": "\"alpha-pinene-oxide decyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51590", "l": "5-pyridoxolactone + H(+) + NADH => isopyridoxal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67614", "l": "a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.22.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46176", "l": "2-methylpropanoate + ATP + CoA = 2-methylpropanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38154", "l": "carbonyl sulfide + H2O <=> CO2 + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632652", "l": "Hh-Npp binds CDON and PTCH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70982", "l": "FH tetramer hydrates fumarate to L-malate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75855", "l": "9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351871", "l": "Caspase-mediated cleavage of Z0-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68412", "l": "H2O + L-glutamate 5-semialdehyde + NADP(+) = 2 H(+) + L-glutamate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380311", "l": "Recruitment of Plk1 to centrosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62453", "l": "ATP + holo-[peptidyl-carrier protein] + L-glutamate => AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678981", "l": "TLR9 processing at neutral pH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11445", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21849", "l": "(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide => (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70958", "l": "H(+)(in) + L-glutamate(in) <=> H(+)(out) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71918", "l": "2 Na(+)(out) + tauronorcholate(out) <=> 2 Na(+)(in) + tauronorcholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51096", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9010815", "l": "SLITs bind keratan sulfate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70643", "l": "D-proline(out) + H(+)(out) = D-proline(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710959", "l": "p-STAT1 dimer binds KPNA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69409", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) => androst-4-ene-3,11,17-trione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56354", "l": "3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+) => 4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813626", "l": "LEAP2 binds bacteria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24798", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O => (S)-2-amino-6-oxoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25596", "l": "2-oxoglutarate + H(+) + isochorismate <=> 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47570", "l": "a ganglioside GD1b (d18:1(4E)) + H(+) + UDP => a ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848370", "l": "IL18 binds IL18R1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35399", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine = beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.213", "l": "\"cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) 6'''-O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8963851", "l": "VD3 dissociates from GC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51224", "l": "2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate = 2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16012", "l": "ATP + formate <=> ADP + formyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018527", "l": "cyclohexylamine oxidase activity", "d": ["Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392834", "l": "Activation of EPACs by cAMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27776", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74160", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19147", "l": "D-glucose + H(+) + sulfate => D-glucose 6-sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004128", "l": "cytochrome-b5 reductase activity, acting on NAD(P)H", "d": ["Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168640", "l": "Ubiquitinated IkB is degraded (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75891", "l": "holothin + pseudomonoyl-CoA C = CoA + pseudomonic acid C--holothin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876472", "l": "NPC2 binds CHOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34818", "l": "2 NADP(+) + tetrahydrocurcumin <=> curcumin + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24270", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH => 2,6-dioxo-6-phenylhexanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20701", "l": "ATP + lipid A disaccharide (E. coli) => ADP + H(+) + lipid IVA (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867047", "l": "PTPN3 dephosphorylates EPS15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690493", "l": "RHOB binds effectors on endosomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23942", "l": "5-dehydro-D-gluconate + H(+) + NADH => D-gluconate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28511", "l": "arbutin 6-phosphate + H2O => beta-D-glucose 6-phosphate + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850997", "l": "TRIM27 binds PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55661", "l": "2 AH2 + all-trans-beta-carotene + 2 O2 => 2 A + echinenone + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56103", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39770", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73930", "l": "griseophenone D + S-adenosyl-L-methionine <=> griseophenone C + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174494", "l": "Synthesis of ENV polyprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730847", "l": "Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844600", "l": "CIDEA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654159", "l": "Activated FGFR2 binds PLCG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76783", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] = 1,9-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75906", "l": "ADP-D-glycero-beta-D-manno-heptose + L-seryl-[protein] <=> ADP + H(+) + O-(D-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25147", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde = H(+) + H2O + quinolinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38507", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800042", "l": "TP53 binds the IGFBP3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168640", "l": "Ubiquitinated IkB is degraded (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19076", "l": "ATP + L-seryl-[I-kappa-B protein] <=> ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22895", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) <=> (6R)-5,10-methenyltetrahydrofolate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199404", "l": "CD40L binds CD40 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375140", "l": "CDO binds promyogenic cadherins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50909", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 => A + a 3-demethylubiquinol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467811", "l": "Separation of sister chromatids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782820", "l": "USP17 deubiquitinates SUDS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047185", "l": "N-acetylneuraminate 4-O-acetyltransferase activity", "d": ["Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38925", "l": "a ubiquinol + Na(+)(out) + NAD(+) => a ubiquinone + H(+) + Na(+)(in) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56727", "l": "AH2 + all-trans-beta-carotene + O2 <=> 4-hydroxy-all-trans-beta-carotene + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005091", "l": "guanyl-nucleotide exchange factor adaptor activity", "d": ["The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70590", "l": "H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) <=> acetate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74920", "l": "a (2E)-2-fatty-enoyl-AMP + holo-[ACP] => a (2E)-enoyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42010", "l": "5alpha-pregnane-3,20-dione + H(+) + NADH => 5alpha-pregnan-20beta-ol-3-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48136", "l": "a ganglioside GM3 + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45208", "l": "coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] = Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}, {"i": "EC:2.1.1.246", "l": "\"[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837337", "l": "DCAKD phosphorylates DP-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57162", "l": "(3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034558", "l": "technetium (VII) reductase activity", "d": ["Catalysis of the reaction: pertechnetate ion + 3/2 H2 = technetium (IV) oxide + H2O + OH-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63291", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34566", "l": "CDP-alpha-D-abequose + NADP(+) <=> CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19227", "l": "5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin] => glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10421", "l": "pyruvate + taurine => L-alanine + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396393", "l": "NOTCH1 PEST domain mutants bind MYC promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69173", "l": "Joining of adjacent Okazaki fragments (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009672", "l": "auxin:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052876", "l": "methylamine dehydrogenase (amicyanin) activity", "d": ["Catalysis of the reaction: 2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H+ + NH4+ + 2 reduced [amicyanin]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56206", "l": "3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36159", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin] = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68417", "l": "cis-(homo)2aconitate + H2O => (2R,3S)-iso(homo)2citrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16030", "l": "3-guanidinopropanoate + H2O => beta-alanine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72554", "l": "glutarate(out) + urate(in) <=> glutarate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60974", "l": "H(+) + hexanal + NADH => hexan-1-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035987", "l": "Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16610", "l": "AMP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21065", "l": "[protein]-disulfide + 2 glutathione => [protein]-dithiol + glutathione disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50234", "l": "biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794475", "l": "Cipro:ALB dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12312", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 = 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.14.22", "l": "\"dibenzothiophene sulfone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31094", "l": "acetyl-CoA + dodecanoyl-CoA <=> 3-oxotetradecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067640", "l": "IL6 binds IL6R-2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34374", "l": "H2O + indole-3-acetamide <=> (indol-3-yl)acetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67148", "l": "L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2 = 2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42488", "l": "(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III = 3'-N-debenzoyl-2'-deoxytaxol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052892", "l": "aromatic (S)-hydroxynitrile lyase activity", "d": ["Catalysis of the reaction: an aromatic (S)-hydroxynitrile = an aromatic aldehyde + cyanide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374662", "l": "Translocation of Ezrin to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34777", "l": "a 3-oxosteroid + CO2 + NADH => a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71560", "l": "5-N(alpha)-glycyl-dTMP in DNA + A + H2O => 5-aminomethyl-dUMP in DNA + AH2 + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832123", "l": "HNF1B binds the IRX1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388596", "l": "Melanocortin receptors bind melanocortins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75081", "l": "32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797090", "l": "CCNK binds CDK12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65519", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O <=> NH4(+) + pre-mycofactocin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295632", "l": "PPA2A dephosphorylates SPRY2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047425", "l": "1-pyrroline-4-hydroxy-2-carboxylate deaminase activity", "d": ["Catalysis of the reaction: 4-hydroxy-1-pyrroline-2-carboxylate + H2O + H+ = 2,5-dioxopentanoate + NH4."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171106", "l": "LDLR:LDL complex => LDLR + LDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12990", "l": "a dolichyl beta-D-mannosyl phosphate + H2O => a dolichyl phosphate + D-mannose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43662", "l": "ADP + H(+) + methylmalonyl-CoA + phosphate => ATP + hydrogencarbonate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50658", "l": "2-(2-methylsulfanyl)ethylmaleate + H2O => 3-(2-methylsulfanyl)ethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9834821", "l": "p-PRKRA dimer binds PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17566", "l": "myo-inositol + S-adenosyl-L-methionine => 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42360", "l": "D-allulose = keto-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198983", "l": "NKG2D homodimer interacting with ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64630", "l": "CoA + octyl acetate => acetyl-CoA + octan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54773", "l": "ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47657", "l": "acetyl-CoA + L-methionine sulfone => CoA + H(+) + N-acetyl-L-methionine sulfone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44311", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34237", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite => 4-nitro-6-oxohepta-2,4-dienedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44783", "l": "2-demethylmenaquinol-9 + S-adenosyl-L-methionine <=> H(+) + menaquinol-9 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78677", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + silphinene-15-oate => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + silphinene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48489", "l": "all-trans-retinol--[retinol-binding protein] + NAD(+) => all-trans-retinal--[retinol-binding protein] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14691", "l": "3,4-dihydroxyphenylacetate + chloride + NAD(+) => 4-chlorophenylacetate + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54302", "l": "n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+) => n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67846", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26240", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (2E,6E,10E)-geranylgeraniol + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676595", "l": "TRAFs bind RANK:RANKL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60730", "l": "3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH => citral + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58075", "l": "a 4,5-didehydrojasmonate + H(+) + NADPH <=> a jasmonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0033207", "l": "beta-1,4-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50055", "l": "ATP + H2O + taurocholate(in) <=> ADP + H(+) + phosphate + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202714", "l": "CD58 binds CD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27344", "l": "AH2 + NH4(+) + O2 <=> A + H(+) + H2O + hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20079", "l": "2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(18) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57782", "l": "3-chloro-4-methylcatechol + NAD(+) + nitrite => 2-chloro-4-nitrotoluene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51256", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2 = (9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63040", "l": "H2O + lovastatin = H(+) + lovastatin carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22604", "l": "D-mannose = D-fructose", "d": [], "t": []}, {"i": "EC:5.3.1.7", "l": "\"mannose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948027", "l": "RNASEs bind bacterial phospholipids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16255", "l": "H(+) + NADH + phenanthrene-3,4-diol => (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.204", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0001681", "l": "sialate O-acetylesterase activity", "d": ["Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18704", "l": "arsenite + H2O + 2 oxidized [azurin] <=> arsenate + 3 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140412", "l": "zinc:bicarbonate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) = zinc(in) + HCO3-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201608", "l": "Caspase-mediated cleavage of alpha adducin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25880", "l": "2 L-dopa + O2 = 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)", "d": [], "t": []}, {"i": "EC:1.13.12.15", "l": "\"3,4-dihydroxyphenylalanine oxidative deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607002", "l": "Activated protein C cleaves factor VIIIa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24520", "l": "H2O + L-saccharopine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH", "d": [], "t": []}, {"i": "EC:1.5.1.9", "l": "\"saccharopine dehydrogenase (NAD(+), L-glutamate-forming)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694433", "l": "MIA2 binds PREB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805479", "l": "TP53RK phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034795", "l": "cyclohexane monooxygenase activity", "d": ["Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12305", "l": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) => 2 H(+) + L-2-aminoadipate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835944", "l": "ADAR1 binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48375", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56865", "l": "12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH => (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678327", "l": "MIOX oxidises Ins to GlcA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54434", "l": "a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate => 2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20834", "l": "ADP + guanine(in) + H(+) + phosphate => ATP + guanine(out) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31300", "l": "H2O + NAD(+) + perillyl aldehyde => 2 H(+) + NADH + perillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61296", "l": "5-deoxy-alpha-D-ribose 1-phosphate = 5-deoxy-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665989", "l": "DIAPH1 binds RHOA:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76535", "l": "FAD(in) = FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25138", "l": "phosphate + pyridoxamine <=> H2O + pyridoxamine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66431", "l": "D-arabinose(out) + H(+)(out) <=> D-arabinose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64047", "l": "(13Z)-docosenoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47129", "l": "ATP + CoA + deoxycholate => AMP + deoxycholoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390930", "l": "5-HT2 receptor can bind serotonin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71153", "l": "(E)-caffeoylpyruvate + CO2 + hnu => 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034074", "l": "marneral synthase activity", "d": ["Catalysis of the reaction: oxidosqualene = marneral."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.-", "l": "\"Methyltransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38473", "l": "3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine => L-histidine + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22081", "l": "H(+) + NADH + O2 + quinolin-2-ol => H2O + NAD(+) + quinoline-2,8-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13440", "l": "(E)-cinnamate + UDP-alpha-D-glucose <=> 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47770", "l": "2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78877", "l": "a medium-chain 3-oxoacyl-CoA + H(+) + NADH => a medium-chain (3R)-hydroxyacyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036041", "l": "Defective IDUA does not hydrolyse the unsulfated alpha-L-iduronosidic link in DS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177930", "l": "GAB1 phosphorylation by EGFR kinase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29957", "l": "H(+)(out) + thymidine(out) => H(+)(in) + thymidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17904", "l": "S-adenosyl-L-methionine + xanthotoxol <=> H(+) + S-adenosyl-L-homocysteine + xanthotoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43034", "l": "2-aminoprop-2-enoate + chloride + H(+) => 3-chloro-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873917", "l": "Translocation of STAT1 dimer to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5681987", "l": "LC3 is cleaved by ATG4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731931", "l": "EDNRA binds selective ERAs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052895", "l": "N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity", "d": ["Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43300", "l": "a neolactoside IV(3)-alpha-NeuGc-nLc4Cer + UDP-N-acetyl-alpha-D-galactosamine = a neolactoside IV(4)-beta-GalNAc-IV(3)-alpha-NeuGc-nLc4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76157", "l": "19-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin] => 21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788061", "l": "Fibronectin degradation by ADAM8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17642", "l": "H(+) + L-arginine => agmatine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50223", "l": "(S)-demethyl-4-deoxygadusol <=> (R)-demethyl-4-deoxygadusol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56734", "l": "echinenone + H2O => 4,4-dihydroxy-all-trans-beta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380586", "l": "loading of Serotonin in synaptic vesicles (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173723", "l": "C8 binds C5b:C6:C7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12186", "l": "(S)-acetoin + H(+) + NADH => (S,S)-butane-2,3-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22123", "l": "CoA + GTP + succinate <=> GDP + phosphate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73462", "l": "5 H(+) + 2 O2 + protochlorophyllide a + 4 reduced [2Fe-2S]-[ferredoxin] <=> 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21648", "l": "H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.51", "l": "\"prephenate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43684", "l": "ATP + L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphate = AMP + diphosphate + H(+) + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416516", "l": "GRK2 sequesters activated Gq (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67452", "l": "a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.117", "l": "\"(4-O-methyl)-D-glucuronate--lignin esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36772", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693575", "l": "DNA-PKcs autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40020", "l": "ent-copalyl diphosphate + H2O => (-)-ent-copalol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17128", "l": "H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine <=> 2-oxoglutarate + N-(2-aminobutanoyl)glycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75757", "l": "10-hydroxyoctadecanoate => (10E)-octadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12750", "l": "3,4,5-trihydroxybenzoate + H(+) => 1,2,3-trihydroxybenzene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13095", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614933", "l": "ACEIs bind ACE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32172", "l": "H(+) + NADPH + O2 + phenylacetyl-CoA => 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54613", "l": "2-oxoglutarate + 3-methylbutanoyl-CoA + O2 => 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008011", "l": "structural constituent of pupal chitin-based cuticle", "d": ["The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218824", "l": "p-6Y-VEGFR2 binds FYN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36471", "l": "3,4,5-trihydroxybenzoate(out) + H(+)(out) = 3,4,5-trihydroxybenzoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797961", "l": "CHDH oxidises Cho to BETALD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33682", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71161", "l": "H(+)(out) + L-serine(in) + Na(+)(in) => H(+)(in) + L-serine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134800", "l": "STING dimerization (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62153", "l": "dGMP + dTTP => dGDP + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211951", "l": "CYP1B1 4-hydroxylates EST17b (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22792", "l": "isonocardicin A = nocardicin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11276", "l": "4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O", "d": [], "t": []}, {"i": "EC:1.10.3.2", "l": "\"laccase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55551", "l": "N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902051", "l": "(25S)-Delta(4)-dafachronate binding", "d": ["Binding to (25S)-Delta(4)-dafachronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78347", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120285", "l": "tyrosine sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of tyrosine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31033", "l": "beta-D-glucopyranosyl cis-(+)-abscisate + UDP => 2-cis-(+)-abscisate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046539", "l": "histamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9824979", "l": "XPO1 binds p-S69,73 MITF-M (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090422", "l": "thiamine pyrophosphate transmembrane transporter activity", "d": ["Enables the transfer of thiamine pyrophosphate a substance from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972978", "l": "POU5F1 (OCT4), SOX2, NANOG bind the ZIC3 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56555", "l": "ATP + L-threonyl-[rhodopsin] <=> ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725206", "l": "IgE binds FCERI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22320", "l": "2 alpha-D-glucose 1-phosphate + H2O = D-maltose + 2 phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.139", "l": "\"maltose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32569", "l": "(1R,4S)-camphene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48163", "l": "3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] <=> epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77154", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O <=> 1D-myo-inositol 4,5-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018485", "l": "salicylaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012016", "l": "FAHD1 dimer hydrolyses OA to PYR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70067", "l": "a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75603", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = plasmodiophorol A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32432", "l": "(1R,4S)-menthone + H(+) + NADPH + O2 => (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46910", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76271", "l": "N,N-dimethylglycine(in) = N,N-dimethylglycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42816", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78904", "l": "a medium-chain fatty acyl-CoA + acetyl-CoA => a medium-chain 3-oxoacyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78979", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = bonnadiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0046974", "l": "histone H3K9 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of up to three methyl groups to the lysine residue at position 9 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74760", "l": "isorhamnetin + S-adenosyl-L-methionine => 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65159", "l": "2-oxoglutarate + O2 + preaustinoid A2 <=> CO2 + H2O + preaustinoid A3 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49283", "l": "FADH2 + O2 + phenol <=> catechol + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034844", "l": "naphthyl-2-methyl-succinate CoA-transferase activity", "d": ["Catalysis of the reaction: naphthyl-2-methyl-succinate + succinyl-CoA = naphthyl-2-methyl-succinyl-CoA + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005469", "l": "succinate:fumarate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)."], "t": []}, {"i": "RHEA:29323", "l": "fumarate(in) + succinate(out) = fumarate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72291", "l": "2,3-dimethylsuccinate(out) + 3 Na(+)(out) = 2,3-dimethylsuccinate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.233", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67142", "l": "H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein] => L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15933", "l": "(S)-propane-1,2-diol + NAD(+) = (S)-lactaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76642", "l": "cytosine(out) <=> cytosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373342", "l": "CX3CR1 binds CX3CL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47690", "l": "Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH => cis-4-hydroxy-L-proline + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10288", "l": "H2O + L-rhamnono-1,4-lactone = H(+) + L-rhamnonate", "d": [], "t": []}, {"i": "EC:3.1.1.65", "l": "\"L-rhamnono-1,4-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31321", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP => (2R)-3-phosphoglycerate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75628", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O => ectocarpin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72532", "l": "ATP + H2O + methyl beta-D-galactoside(out) => ADP + H(+) + methyl beta-D-galactoside(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.078676747242454", "identifiers": [{"i": "GO:0008146", "l": "sulfotransferase activity", "d": ["Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56031", "l": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38976", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417842", "l": "P2Y10 receptor can bind to LPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215295", "l": "USP7 deubiquitinates MDM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43912", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64569", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one => ilicicolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54405", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O => 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688797", "l": "ATXN3 family cleave Ub chains (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66334", "l": "L-aspartate(in) => L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40868", "l": "(9E)-octadecenoyl-CoA + FAD + H(+) => (2E,9E)-octadecadienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57217", "l": "dGTP + glyoxal => N(2)-(1-hydroxy-2-oxoethyl)-dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047216", "l": "inositol 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58727", "l": "adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35086", "l": "diacetylchitobiose-6'-phosphate + H2O <=> acetate + N'-monoacetylchitobiose-6'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.16", "l": "\"formyl-CoA transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420274", "l": "GIP receptor binds gastric inhibitory peptide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.69", "l": "\"glycosphingolipid deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018611", "l": "toluate dioxygenase activity", "d": ["Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227881", "l": "Phosphorylation and release of IRF3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9626928", "l": "CREBBP binds FOXO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39045", "l": "docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2529020", "l": "CK2 phosphorylates condensin I subunits (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433395", "l": "Dimerization of sSCF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24275", "l": "H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 <=> H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106245", "l": "L-serine-phosphatidylethanolamine phosphatidyltransferase activity", "d": ["Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58986", "l": "acrylate + H(+) + H2O2 => acrolein + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33336", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O => 1,2-dioctadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25035", "l": "all-trans-retinal + H(+) + NADPH => all-trans-retinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3229181", "l": "CALM1:Ca2+ binds CNG channel (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37553", "l": "2-oxoglutarate + D-kanosamine 6-phosphate => 3-dehydro-D-glucose 6-phosphate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.72", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874979", "l": "ACBD3 binds GOLGB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:1901474", "l": "azole transmembrane transporter activity", "d": ["Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23452", "l": "2'-deoxyadenosine + ATP = ADP + dAMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9842655", "l": "IRS1 recruits GRB2 to active LTK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30642", "l": "(R)-glycerate + GDP-alpha-D-mannose <=> (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29379", "l": "dGMP + H2O = 2'-deoxyguanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209891", "l": "Dopamine is oxidised to noradrenaline (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29979", "l": "2'-deoxyadenosine(in) + H(+)(in) = 2'-deoxyadenosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22961", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] => calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732107", "l": "FOXD3 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129362", "l": "Fibrillin microfibril assembly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25017", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.67", "l": "\"phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54644", "l": "trans-4-hydroxy-L-proline = (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.172", "l": "\"trans-4-hydroxy-L-proline dehydratase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57062", "l": "acetate + ADP-D-ribose + H(+) => 2''-O-acetyl-ADP-D-ribose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71963", "l": "(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) = (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.21", "l": "\"astacin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865605", "l": "BRWD1 binds SMARCA4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804527", "l": "INTL1 binds bacterial glycans (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20613", "l": "3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine = adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31075", "l": "(3S)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102673", "l": "fatty aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(1-) + H2O + a fatty aldehyde = NADH(2-) + 2 H+ + a fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34443", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.210", "l": "\"dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49488", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": [], "t": []}, {"i": "EC:4.2.1.168", "l": "\"GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30744", "l": "beta-nicotinamide D-riboside + H2O => D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858475", "l": "TNFSF9 binds TNFRSF9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4088130", "l": "PLK1 binds FOXM1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57240", "l": "glyoxal + GMP = N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201622", "l": "Caspase-mediated cleavage of gelsolin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37879", "l": "methyl aklanonate = aklaviketone", "d": [], "t": []}, {"i": "EC:5.5.1.23", "l": "\"aklanonic acid methyl ester cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0051018", "l": "protein kinase A binding", "d": ["Binding to a protein kinase A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70729", "l": "6-sulfo-alpha-D-quinovose + glycerol => 3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1364044", "l": "PRLR:JAK2 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947535", "l": "Cyclisation of GTP to precursor Z (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59524", "l": "9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] = 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78484", "l": "2-amino-4-phosphonobutanoate + CTP => CMP-5'-(3-amino-3-carboxypropyl)phosphonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73061", "l": "Ca(2+)(out) + Mn(2+)(in) => Ca(2+)(in) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76182", "l": "a dipeptide(out) + 2 H(+)(out) <=> a dipeptide(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45943", "l": "12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1250264", "l": "TXNIP binds reduced thioredoxin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50058", "l": "ADP + glycocholate(out) + H(+) + phosphate => ATP + glycocholate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806610", "l": "Keratin filament formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167876", "l": "SMAD7:SMURF2 complex translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20912", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene", "d": [], "t": []}, {"i": "EC:4.2.3.17", "l": "\"taxadiene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63069", "l": "acetyl-CoA + 2 H(+) + 2 malonyl-CoA => 2 CO2 + 3 CoA + triacetate lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74851", "l": "acetaldehyde + dopamine = (R)-salsolinol + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.214", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34596", "l": "H(+) + isopentadecanoyl-CoA + L-serine => 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66325", "l": "iodide(out) => iodide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432295", "l": "GPVI binds Fyn and Lyn (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60179", "l": "5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O <=> 5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097258", "l": "20-hydroxy-leukotriene B4 omega oxidase activity", "d": ["Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-oxo-leukotriene B4 + H+ + 2 H2O + oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29150", "l": "2 H(+)(in) + nitrate + ubiquinol-8 <=> 2 H(+)(out) + H2O + nitrite + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55778", "l": "all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + H(+) + UDP => all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48068", "l": "a ganglioside GM2 (d18:1(4E)) + H2O = a ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59539", "l": "ATP + butanoyl-CoA + hydrogencarbonate <=> (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14192", "l": "D-tryptophan + O2 <=> N-formyl-D-kynurenine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694452", "l": "Protein E forms a homopentamer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0000149", "l": "SNARE binding", "d": ["Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30588", "l": "2-demethylmenaquinol-8 + dimethyl sulfoxide => 2-demethylmenaquinone-8 + dimethyl sulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848726", "l": "PTK6 phosphorylates BCAR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823849", "l": "Expression of GATA4 in definitive endoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20856", "l": "an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine", "d": [], "t": []}, {"i": "EC:3.5.1.23", "l": "\"ceramidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247840", "l": "WLS binds WNT ligands in the Golgi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9853368", "l": "FIRRM binds FIGNL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014652", "l": "Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43337", "l": "H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) => CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68099", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O <=> a 3'-end ribonucleotide-RNA + a 5'-end 5'-phospho-ribonucleoside-RNA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77337", "l": "alpha-D-mannosyl-(1->4)-[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-1-O,3-O-dimethyl-alpha-D-mannose + GDP + H(+) => [3-O-methyl-alpha-D-mannosyl-(1->4)](n)-1-O,3-O-dimethyl-alpha-D-mannose + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70613", "l": "GOT2 transaminates OA and L-Glu (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34960", "l": "(R)-carnitine(in) => (R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009488", "l": "IL34 binds CSF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14111", "l": "1-pyrroline-5-carboxylate + 2 H(+) + NADPH => L-proline + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56485", "l": "3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] => gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35899", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20443", "l": "3-sulfino-L-alanine + H(+) => L-cysteine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28755", "l": "a ubiquinone + sn-glycerol 3-phosphate = a ubiquinol + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23725", "l": "H2O + O2 + pyridoxal => 4-pyridoxate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13120", "l": "O-acetyl-L-serine + pyrazole <=> 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617595", "l": "SGTA binds mislocalized membrane protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53034", "l": "17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55869", "l": "(S)-lactate + O2 => H2O2 + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49583", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate <=> cyclic pyranopterin phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373141", "l": "malate <=> fumarate + H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5631885", "l": "PRDX1 overoxidizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52970", "l": "H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP => hyocholate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44268", "l": "3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA = 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32252", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) => (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28407", "l": "H2O + XTP => H(+) + phosphate + XDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35870", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156915", "l": "Translocation of ribosome by 3 bases in the 3' direction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29538", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661432", "l": "BIL binds ALB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390909", "l": "HRH2 binds hist (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0070325", "l": "lipoprotein particle receptor binding", "d": ["Binding to a lipoprotein particle receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69594", "l": "cytidine + IMP => CMP + inosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0023025", "l": "MHC class Ib protein complex binding", "d": ["Binding to a class Ib major histocompatibility complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46094", "l": "(25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823352", "l": "Protein N forms decamers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61166", "l": "H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP => kaempferol + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682598", "l": "ATM phosphorylates HERC2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29255", "l": "Ca(2+)(in) + Na(+)(out) = Ca(2+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0033041", "l": "sweet taste receptor activity", "d": ["Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75686", "l": "(12R,13S)-epoxy-(9Z)-octadecenoate + O2 <=> (12R,13S)-epoxy-(10R)-hydroperoxy-(8E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42127", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) <=> androsterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10457", "l": "acetyl-CoA + D-maltose => 1-O-acetylmaltose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67929", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O => a 3'-end 3'-phosphouridine-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17275", "l": "4-hydroxyphenylacetate + 2 H(+) + NADH => (4-hydroxyphenyl)acetaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733331", "l": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R:GRB2:SOS1 dissociates yielding CSF1 dimer,IL34 dimer:p-Y561-CSF1R:SFK and GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661217", "l": "MT1A binds zinc (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26073", "l": "H2O + UDP-alpha-D-glucuronate = D-glucuronate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16533", "l": "L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.94", "l": "\"protein N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16536", "l": "L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72599", "l": "N-acetyl-L-aspartyl-L-glutamate(out) = N-acetyl-L-aspartyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48493", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031824", "l": "type 1E serotonin receptor binding", "d": ["Binding to a type 1E serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097358", "l": "D-leucyl-tRNA(Leu) deacylase activity", "d": ["Catalysis of the reaction: D-leucyl-tRNA(Leu) = D-leucine + tRNA(Leu). Hydrolysis of the removal of D-leucine from residues in charged tRNA(Leu)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443418", "l": "GP1b signaling involves c-Src (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44429", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol => a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28353", "l": "UDP-beta-L-arabinofuranose <=> UDP-beta-L-arabinopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14553", "l": "(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C", "d": [], "t": []}, {"i": "EC:2.6.1.74", "l": "\"cephalosporin-C transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855375", "l": "PTPN22 dissociates from CSK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607744", "l": "MALT1 binds BCL10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19609", "l": "adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.182", "l": "\"16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0140487", "l": "metal ion sequestering activity", "d": ["Binding to a metal ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42784", "l": "adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.184", "l": "\"23S rRNA (adenine(2085)-N(6))-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38016", "l": "delta-tocotrienol => 6-geranylgeranyl-2-methylbenzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24199", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) <=> (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22378", "l": "pseudouridine(38/39/40) in tRNA => uridine(38/39/40) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168445", "l": "PTP1B binds the GH receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67592", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O = (R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688786", "l": "ATXN3 binds RAD23 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71775", "l": "SUCLG1/G2 cleaves succinyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51055", "l": "5alpha-androstan-3,17-dione + A <=> 5alpha-androst-1-ene-3,17-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014449", "l": "RHOG binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52799", "l": "2 H(+) + Ni-sirohydrochlorin <=> Ni(2+) + sirohydrochlorin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50407", "l": "(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] <=> 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176175", "l": "Stalling of DNA replication fork and RPA binding (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679239", "l": "ULK complex translocates to the ER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790905", "l": "Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0031490", "l": "chromatin DNA binding", "d": ["Binding to DNA that is assembled into chromatin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72695", "l": "UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) = UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793591", "l": "LIAS synthesizes lipoyl-GCSH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784765", "l": "p-Y705-STAT3 dimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16874", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA => (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51851", "l": "8-methylmenaquinone-6 + succinate <=> 8-methylmenaquinol-6 + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30342", "l": "H(+) + L-tryptophan <=> CO2 + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46105", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => corticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38798", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112037", "l": "Inactivation of PLC beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11911", "l": "H2O + nonane-4,6-dione <=> butanoate + H(+) + pentan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11316", "l": "an aliphatic aldoxime = a nitrile + H2O", "d": [], "t": []}, {"i": "EC:4.8.1.2", "l": "\"aliphatic aldoxime dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0023029", "l": "MHC class Ib protein binding", "d": ["Binding to a major histocompatibility complex class Ib molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2169050", "l": "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36834", "l": "2 caldariellaquinol + n H(+)(in) + O2 <=> 2 caldariellaquinone + n H(+)(out) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162186", "l": "COQ3 methylates DeMQ10H2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786567", "l": "KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24069", "l": "cyclohexanone + H(+) + NADPH + O2 => H2O + hexano-6-lactone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694274", "l": "mRNA1 is translated to pp1ab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9727349", "l": "XDH dehydrogenates xanthine to form urate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20178", "l": "pyridoxine + UDP-alpha-D-glucose => 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018754", "l": "GDIs bind RHOH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693536", "l": "ATM phosphorylates MDC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14919", "l": "4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27349", "l": "arsenate + mycothiol = arseno-mycothiol + H2O", "d": [], "t": []}, {"i": "EC:2.8.4.2", "l": "\"arsenate-mycothiol transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19025", "l": "H2O + L-aspartate + O2 = H2O2 + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047280", "l": "nicotinamide phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39720", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate => 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196417", "l": "Reduction of desmosterol to cholesterol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982765", "l": "Growth hormone forms dimers and oligomers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9629679", "l": "PDE3A inhibitors bind PDE3A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.87", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60464", "l": "2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64863", "l": "(E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine <=> (E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031894", "l": "DPAn-3 maresins translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428625", "l": "Vesicular inhibitory amino acid transport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814409", "l": "CK2 phosphorylates PDCL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683751", "l": "M protein gets N-glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-165195", "l": "GTP loading by Rheb (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836702", "l": "PKR inhibitors bind PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35532", "l": "cyclo(L-phenylalanyl-L-leucyl) + 2 O2 => albonoursin + 2 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73995", "l": "geranylgeranyl diphosphate + H2O = (S)-(+)-nephthenol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11457", "l": "N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31144", "l": "(3S)-hydroxyhexanoyl-CoA + NAD(+) => 3-oxohexanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867613", "l": "PICALM binds R-SNAREs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757686", "l": "SERPINA6 binds PREDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989750", "l": "Expression of FATP1 (SLC27A1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112604", "l": "Phosphorylated STATs are released (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851436", "l": "CFHR dimers bind C3b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26393", "l": "all-trans-zeaxanthin + 2 O2 = 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": [], "t": []}, {"i": "EC:1.14.99.n4", "l": "\"carotenoid 9,10-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44463", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol <=> a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53801", "l": "lithocholoyl-CoA + ursodeoxycholate => lithocholate + ursodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51270", "l": "4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine => norbelladine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23012", "l": "a fatty acid + S-adenosyl-L-methionine = a fatty acid methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.15", "l": "\"fatty-acid O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37590", "l": "2-oxoglutarate + D-lysine <=> 6-amino-2-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40725", "l": "(9E)-octadecenoate + CoA + H(+) => (9E)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2509827", "l": "ITPA hydrolyses ITP to IMP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58234", "l": "H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein] => L-seryl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42434", "l": "maleylacetate => 3-hydroxy-cis,cis-muconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660819", "l": "ADORA2B:Ade-Rib:GsGTP dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45819", "l": "(S)-lactate + A <=> AH2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12188", "l": "2-oxoglutarate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] = CO2 + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]", "d": [], "t": []}, {"i": "EC:1.2.4.2", "l": "\"oxoglutarate dehydrogenase (succinyl-transferring)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201629", "l": "Caspase-mediated cleavage of Tau (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65416", "l": "dGMP(in) + NAD(+)(out) = dGMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052733", "l": "quinate 3-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: quinate + NADP+ = 3-dehydroquinate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790041", "l": "Expression of STAT3-upregulated cytosolic proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.942687253280909", "identifiers": [{"i": "GO:0046914", "l": "transition metal ion binding", "d": ["Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047313", "l": "aromatic-amino-acid-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71876", "l": "2 Na(+)(out) + taurocholate(out) => 2 Na(+)(in) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944214", "l": "Association of procollagen type I (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000137", "l": "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070819", "l": "menaquinone-dependent protoporphyrinogen oxidase activity", "d": ["Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43925", "l": "NAD(+) + pregnenolone => H(+) + NADH + pregn-5-ene-3,20-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038147", "l": "C-X-C motif chemokine 12 receptor activity", "d": ["Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71058", "l": "L-cysteine(out) + L-methionine(in) <=> L-cysteine(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43414", "l": "an N-acyl-sphingoid base + D-galactose => a D-galactosylceramide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57753", "l": "2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106141", "l": "flavin prenyltransferase activity", "d": ["Catalysis of the reaction: dimethylallylphosphate + FMNH2 = prenylated FMNH2 + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29665", "l": "H(+)(out) + xanthine(out) => H(+)(in) + xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64245", "l": "a fatty acyl-CoA + glycine => an N-(fatty acyl)-glycine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839064", "l": "YME1L1 binds mitochondrial inner membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20930", "l": "[DsbA protein]-disulfide + a quinol => [DsbA protein]-dithiol + a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-182988", "l": "Sprouty lures CBL away from EGFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1470010", "l": "Dimerization of STATs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76668", "l": "furfural + H2O + NAD(+) => 2-furoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17318", "l": "chlorophyllide a + H(+) + phytyl diphosphate => chlorophyll a + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10952", "l": "(E)-sinapoyl-CoA + hydroxymalonate = (E)-sinapoyltartronate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.106", "l": "\"tartronate O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0140702", "l": "cyclic GMP-AMP binding", "d": ["Binding to cyclic GMP-AMP (cGAMP) nucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088322", "l": "Defective GNE does not phosphorylate ManNAc to ManNAc-6-P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.571199156962493", "identifiers": [{"i": "GO:0140030", "l": "modification-dependent protein binding", "d": ["Binding to a protein upon post-translation modification of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29694", "l": "alpha-maltotetraose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54430", "l": "ADP-D-ribose + H(+) + L-aspartyl-[protein] => 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72442", "l": "(E)-ferulate + ATP + H(+) <=> (E)-feruloyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004315", "l": "3-oxoacyl-[acyl-carrier-protein] synthase activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41692", "l": "1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13442", "l": "H2O + L-cysteate => H(+) + NH4(+) + pyruvate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606789", "l": "ARSB hydrolyses DS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20015", "l": "H(+) + N-carbamoyl-L-aspartate + phosphate => carbamoyl phosphate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0003955", "l": "NAD(P)H dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129353", "l": "Tropoelastin associates with microfibrils (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671772", "l": "p-T38-PPP1R14A binds MLCP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189406", "l": "4 PBGs bind to form HMB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26341", "l": "L-selenocysteine + S-methyl-L-methionine = H(+) + L-methionine + Se-methyl-L-selenocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.280", "l": "\"selenocysteine Se-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685281", "l": "SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9837978", "l": "LONP1 binds mitochondrial inner membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008837", "l": "diaminopimelate epimerase activity", "d": ["Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111238", "l": "Formation of ADAR2  homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944219", "l": "Association of procollagen type XVI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20223", "l": "(6R)-10-formyltetrahydrofolate + ADP + phosphate => (6S)-5,6,7,8-tetrahydrofolate + ATP + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17645", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] = N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0004467", "l": "long-chain fatty acid-CoA ligase activity", "d": ["Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72078", "l": "ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine <=> ADP + H(+) + ophthalmate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.66", "l": "\"calicivirin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-573297", "l": "TRAF6 binding to IRAK2 stimulates its oligomerizartion upon TLR7 or TLR21 stimulation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592398", "l": "Activation of proMMP8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710959", "l": "p-STAT1 dimer binds KPNA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43615", "l": "S-adenosyl-L-methionine + uridine(341) in tmRNA <=> 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36773", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417896", "l": "P2Y6 receptor can bind to UDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210300", "l": "Interaction of DAP12 and TREM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016936", "l": "galactoside binding", "d": ["Binding to a glycoside in which the sugar group is galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68010", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49855", "l": "(3E)-octenoyl-CoA <=> (2E)-octenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022399", "l": "ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44719", "l": "A + all-trans-4,4'-diapolycopen-4-al + H2O <=> AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41327", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75362", "l": "L-mimosine <=> 2-aminoprop-2-enoate + 3-hydroxy-4H-pyrid-4-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685156", "l": "ATR phosphorylates RPA2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052600", "l": "propane-1,3-diamine oxidase activity", "d": ["Catalysis of the reaction: propane-1,3-diamine + H2O + O2 = 3-aminopropanal + NH3 + hydrogen peroxide + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61780", "l": "keto-L-tagatose = keto-L-sorbose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391158", "l": "SIRP alpha binds CD47 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49372", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate = H2O + NAD(+) + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68287", "l": "hexanoyl-CoA + L-seryl-[protein] <=> CoA + O-hexanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014296", "l": "RAC2 GEFs activate RAC2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58107", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0004758", "l": "serine C-palmitoyltransferase activity", "d": ["Catalysis of the reaction: L-serine + H+ + palmitoyl-CoA = 3-dehydrosphinganine + CO2 + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0070990", "l": "snRNP binding", "d": ["Binding to a small nuclear ribonucleoprotein particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56938", "l": "testosterone => 17beta-hydroxy-androst-5-en-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928640", "l": "PAKs phosphorylate MLC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.429442108981661", "identifiers": [{"i": "GO:0016628", "l": "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937059", "l": "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9621179", "l": "Cinaciguat binds sGC:NO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68601", "l": "(2S)-3-sulfopropanediol => 3-oxopropane-1-sulfonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68303", "l": "L-seryl-[protein] + tetradecanoyl-CoA <=> CoA + O-tetradecanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65743", "l": "2-oxoglutarate + nonyl sufate + O2 <=> CO2 + H(+) + nonanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11182", "l": "AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn) => ATP + L-asparagine + tRNA(Asn)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047362", "l": "thiosulfate-dithiol sulfurtransferase activity", "d": ["Catalysis of the reaction: dithioerythritol + thiosulfate = hydrogen sulfide + dithioerythritol disulfide + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46294", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate => a 5'-end triphospho-(purine-ribonucleoside) in mRNA + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70652", "l": "(9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein] => H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247497", "l": "ERBB3 binds neuregulins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14254", "l": "guanosine 3',5'-bis(diphosphate) + H2O => diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050240", "l": "pyrogallol 1,2-oxygenase activity", "d": ["Catalysis of the reaction: O2 + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66796", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694522", "l": "Inner coat assembly and cargo binding (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871265", "l": "YAP1 binds TEAD4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64150", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GalNAc-R + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029471", "l": "Hydrolysis of PC to PA by PLD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74734", "l": "Re-integration of insulin receptor into plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13823", "l": "(S)-2-hydroxyglutarate + CO2 + succinate => 2-oxoglutarate + glutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52673", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32651", "l": "erythromycin D + S-adenosyl-L-methionine = erythromycin B + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322431", "l": "XIAP binds TLE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47329", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874079", "l": "PTK2 binds activated MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75301", "l": "2'cADPR + H(+) + nicotinamide => NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034787", "l": "1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity", "d": ["Catalysis of the reaction: 1-hydro-1,1a-dihydroxy-9-fluorenone + H2O = 2,3-dihydroxy-2'-carboxybiphenyl + 3 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43005", "l": "H(+) + O-carbamoyl-L-serine => 2-aminoprop-2-enoate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047468", "l": "phosphoglucomutase (glucose-cofactor) activity", "d": ["Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610867", "l": "HCMV Binds Host Cell Receptor - Endocytic Pathway (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47014", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine => [DsrC protein]-disulfide + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77090", "l": "isochorismoyl-L-glutamate <=> N-pyruvoyl-L-glutamate + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12191", "l": "2-oxoglutarate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] <=> CO2 + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28761", "l": "alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+) => beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70918", "l": "guanosine(in) + H(+)(in) <=> guanosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41160", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46131", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69444", "l": "(2E,6E)-farnesyl diphosphate = alpha-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62793", "l": "3 H(+) + NADPH + O2 + 2 rubrofusarin B => 2 H2O + NADP(+) + nigerone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028583", "l": "Phosphorylation of YAP by LATS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15065", "l": "H2O + N(4)-benzoylagmatine = agmatine + benzoate", "d": [], "t": []}, {"i": "EC:3.5.1.40", "l": "\"acylagmatine amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939201", "l": "ESR dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52907", "l": "15,17(3)-seco-F430-17(3)-acid + ATP <=> ADP + coenzyme F430 + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173642", "l": "Disintegration of matrix layer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982637", "l": "Opsins binds G alpha-t (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56742", "l": "a globoside GalGb3Cer + H(+) + UDP => a globoside Gb3Cer + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54677", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (+)-kolavenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471314", "l": "HNP1-3 bind CD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377640", "l": "Autophosphorylation of SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140680", "l": "histone H3K36me/H3K36me2 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047630", "l": "ADP-phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 3-ADP-2-phosphoglycerate + H2O = 3-ADP-glycerate + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72112", "l": "L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) => L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76937", "l": "2-methylpropanal + H(+) + NADH + NH4(+) => 2-methylpropan-1-amine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22845", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873917", "l": "Translocation of STAT1 dimer to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900756", "l": "NOTCH1 HD+PEST domain mutants bind JAG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65302", "l": "CO2 + H2O + succinate + verruculide A => 2-oxoglutarate + chrodrimanin C + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59943", "l": "2-methyloctadecanoyl-CoA + H2O <=> 2-methyloctadecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9659611", "l": "ANO1 inhibitors bind ANO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37240", "l": "2',3'-cyclophospho-UMP + H2O => H(+) + uridine 2'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.118", "l": "\"glucose 1-dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10912", "l": "(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.2.1", "l": "\"pantoate--beta-alanine ligase (AMP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41608", "l": "3'-phosphoadenylyl sulfate + alpha,alpha-trehalose = 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.37", "l": "\"trehalose 2-sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9015111", "l": "Factor Xa inhibitors binds Xa (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005334", "l": "norepinephrine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21248", "l": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034802", "l": "branched-chain dodecylbenzene sulfonate monooxygenase activity", "d": ["Catalysis of the reaction: branched-chain dodecylbenzene sulfonate + 1/2 O2 + H+ = sulfurous acid + branched-chain dodecyl-4-hydroxy-benzene + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876446", "l": "p-ULK1 phosphorylates DENND3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018826", "l": "RHOT2 hydrolyzes GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67689", "l": "2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O => 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832574", "l": "NS1 (1C) binds to NS2 (1B) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56848", "l": "1,6-didemethyltoxoflavin + S-adenosyl-L-methionine = H(+) + reumycin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.55", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63053", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39365", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O => (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27324", "l": "3-epi-6-deoxocathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxotyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34615", "l": "2-hydroxyethylphosphonate + O2 = H(+) + hydrogencarbonate + methylphosphonate", "d": [], "t": []}, {"i": "EC:1.13.11.73", "l": "\"methylphosphonate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57867", "l": "indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018538", "l": "DLGAP5 gene transcription is stimulated by NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58063", "l": "2-sulfinoacetaldehyde + H2O <=> acetaldehyde + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730887", "l": "Autophosphorylation and activation of MEKK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661980", "l": "F8 variant is not secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9656891", "l": "OPN1SW binds 11cRAL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73470", "l": "beta-alanyl-dopamine + H2O <=> beta-alanine + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49853", "l": "(3E)-octenoyl-CoA => (2E)-octenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620103", "l": "ALDH2 transforms GTN to NO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798474", "l": "S100A8:S100A9 binds Zn2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047464", "l": "heparosan-N-sulfate-glucuronate 5-epimerase activity", "d": ["Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665761", "l": "FMNL3 binds RHOC:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036190", "l": "indole-2-monooxygenase activity", "d": ["Catalysis of the reaction: indole + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3858489", "l": "ppDVL binds DAAM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47571", "l": "a ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose <=> a ganglioside GD1b (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015309", "l": "cycloheximide:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37149", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006585", "l": "PTPN4 gene expression is stimulated by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981713", "l": "C4b binds to cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44462", "l": "a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.103", "l": "\"teichoic acid D-alanine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54003", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40306", "l": "A + dodecanedioyl-CoA <=> (2E)-dodecenedioyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0003905", "l": "alkylbase DNA N-glycosylase activity", "d": ["Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866304", "l": "pre-VLDL binds lipids to form VLDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035979", "l": "histone H2AXS139 kinase activity", "d": ["Catalysis of the reaction: histone H2AX-serine (position 139) + ATP = histone H2AX-phosphoserine (position 139) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 139 of histone variant H2AX."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754130", "l": "CDK4 inhibitors bind CDK4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46359", "l": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60469", "l": "3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653893", "l": "ATF4, CEBPB, and ATF3 bind the CHAC1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31322", "l": "(2R)-3-phosphoglycerate + UDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61922", "l": "(2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate => (2R,4S)-ketoconazole(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350362", "l": "ROK phosphorylates MBS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9702818", "l": "CALCR binds erenumab (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9861640", "l": "CTLH E3 ligase ubiquitinates PKM-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58007", "l": "(20S)-ginsenoside F2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rd + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11194", "l": "a (2R)-2-hydroxycarboxylate + a halide anion + H(+) => an (S)-2-haloacid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31394", "l": "15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) <=> all-trans-4,4'-diapolycopene + 4 FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69299", "l": "CDT1 binds geminin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11484", "l": "a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)", "d": [], "t": []}, {"i": "EC:7.1.1.8", "l": "\"quinol--cytochrome-c reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69814", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53228", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48713", "l": "2 Fe(2+) + 2 H(+) + H2O2 => 2 Fe(3+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018826", "l": "RHOT2 hydrolyzes GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64923", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H2O <=> a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981931", "l": "RAC1 and CDC42 activate PAK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53467", "l": "1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824653", "l": "p-S133-CREB1 binds MITF promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77507", "l": "(E)-cinnamaldehyde + hydrogen cyanide = (2S,3E)-2-hydroxy-4-phenylbut-3-enenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202472", "l": "Translocation of TRAF6 to CBM complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45383", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17650", "l": "acetyl-[ACP] + malonate => acetate + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14065", "l": "scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.44", "l": "\"myo-inosose-2 dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11433", "l": "S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside => 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43224", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796368", "l": "RIPK1 binds STUB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12228", "l": "ATP + H2O + L-aspartate + L-glutamine = AMP + diphosphate + H(+) + L-asparagine + L-glutamate", "d": [], "t": []}, {"i": "EC:6.3.5.4", "l": "\"asparagine synthase (glutamine-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169847", "l": "Assembly of NA tetramers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64518", "l": "H(+) + NADH + sulfoacetaldehyde => 2-hydroxyethane-1-sulfonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807585", "l": "BPI binds LPS on the bacterial surface (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71018", "l": "H2O + N-methylputrescine + O2 <=> 4-methylaminobutanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728664", "l": "GLP1R binds GLP1R agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047402", "l": "protein-glucosylgalactosylhydroxylysine glucosidase activity", "d": ["Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose. The enzyme specifically hydrolyzes glucose from alpha-D-glucosyl- (1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19120", "l": "dopamine + 2 L-ascorbate + O2 <=> (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-996755", "l": "ZFPM proteins bind GATA proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11907", "l": "2-amino-4-hydroxypteridine + H(+) + H2O <=> 2,4-dihydroxypteridine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936381", "l": "OTUD5 deubiquitinates TRAF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22296", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate = (1R,2R,3R)-prephytoene diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25551", "l": "(+)-copalyl diphosphate <=> abieta-8(14),12-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59528", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27556", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28490", "l": "H(+)(in) + K(+)(in) = H(+)(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77851", "l": "(2S)-3-(4-hydroxyphenyl)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O = 2-dehydro-D-glucose + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635804", "l": "ATF4 and phospho-ATF2 bind the DDIT3 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48451", "l": "a ganglioside GA2 + H2O <=> a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71557", "l": "5-aminoethyl-dUMP in DNA + CO2 => 5-C(alpha)-glycyl-dTMP in DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10317", "l": "2-oxoglutarate + O2 + thymine => 5-hydroxymethyluracil + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76553", "l": "CoA + H(+) + N-acetyl-D-aspartate => acetyl-CoA + D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54857", "l": "H(+) + NADPH + O2 + octan-3-one => ethyl hexanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72889", "l": "ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + polyporic acid + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400012", "l": "Acetylcholine binds Muscarinic Acetylcholine Receptor M3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592362", "l": "Activation of proMMP7 by MMP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43417", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404193", "l": "IGF1R phosphorylates SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937034", "l": "IRAK1 phosphorylates Pellino (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175117", "l": "1-LTR circle formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74708", "l": "fumagillol + NADP(+) => 5-dehydrofumagillol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76804", "l": "2-aminopentan-1-ol + H2O + NAD(+) => 1-hydroxypentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33244", "l": "L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60393", "l": "Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O => Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5213464", "l": "RIPK1 is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140797", "l": "histone H3R17 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl (position 17)= histone H3 L-citrullyl (position 17) + NH4+, resulting in histone H3 citrullination at position 17."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47508", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH = isolithocholate + NAD(+)", "d": [], "t": []}, {"i": "EC:1.1.1.391", "l": "\"3beta-hydroxycholanate 3-dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58896", "l": "4-hydroxybutanoate + ATP + CoA = 4-hydroxybutanoyl-CoA + ADP + phosphate", "d": [], "t": []}, {"i": "EC:6.2.1.56", "l": "\"4-hydroxybutyrate--CoA ligase (ADP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46736", "l": "H2O + monoacyl-sn-glycero-3-phosphate = a monoacylglycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78965", "l": "a 1,2-diacyl-sn-glycerol + H(+) + O-phospho-L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44680", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46383", "l": "7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74302", "l": "D-isoleucine(out) + D-serine(in) <=> D-isoleucine(in) + D-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20434", "l": "NAD(+) + xylitol => D-xylulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44242", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66743", "l": "ATP + H2O + N-acetyl-L-glutamate(in) <=> ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77710", "l": "GTP + UTP <=> 3',3'-cGMP-UMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854209", "l": "TBC1D10A binds JFC1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948757", "l": "AKT phosphorylates MKRN1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69786", "l": "(2-aminophenyl)succinate + succinyl-CoA <=> 2-(2-aminophenyl)succinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10839", "l": "NADPH + O2 + questin <=> demethylsulochrin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981892", "l": "Active G alpha (z) binds RGS proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.55", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016519", "l": "gastric inhibitory peptide receptor activity", "d": ["Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638222", "l": "Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102836", "l": "1-18:1-2-16:1-monogalactosyldiacylglyceroldesaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-921155", "l": "p-STAT5 dissociates from the receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212614", "l": "Glutamine transport from astrocytes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62485", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427570", "l": "Group 3 - Selective Cl- transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701903", "l": "ALK-, STAT3- and MECP2-dependent STAT5A gene repression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018569", "l": "hydroquinone 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912627", "l": "CBL ubiquitinates PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814409", "l": "CK2 phosphorylates PDCL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77345", "l": "5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate => N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473186", "l": "FSTL3 binds Activin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74129", "l": "peonidin 3-O-beta-D-galactoside + UDP => peonidin + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17701", "l": "ATP + geranoyl-CoA + hydrogencarbonate = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.4.1.5", "l": "\"geranoyl-CoA carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68529", "l": "(2E,6E)-farnesyl diphosphate => beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42056", "l": "13-cis-retinol + NAD(+) = 13-cis-retinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22450", "l": "ADP + H(+) + psi-UMP => ATP + pseudouridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-140806", "l": "SERPINC1 binds SERPINC1 activators (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.338", "l": "\"desmethylxanthohumol 6'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30051", "l": "fluoroacetate + H2O = fluoride + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295599", "l": "SPRY2 translocates to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53937", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 => 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42081", "l": "all-trans-retinal + H2O + NAD(+) => all-trans-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36311", "l": "3,4-dihydroxybenzaldehyde + H2O + NAD(+) = 3,4-dihydroxybenzoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863494", "l": "ASICs bind STOML3, (STOM) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37257", "l": "2-oxosuccinamate + AH2 + NH4(+) => A + D-asparagine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44202", "l": "12-methyloctadecanoyl-CoA + AMP + diphosphate => 12-methyloctadecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.99.-", "l": "\"With H(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77068", "l": "Activation of GT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849906", "l": "SALM1 binds NMDA receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32928", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685296", "l": "GATA6 binds SFTPA genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62023", "l": "H2O + sitosteryl 3-beta-D-glucoside <=> D-glucose + sitosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786092", "l": "IL4:IL4R:JAK2 binds IL2RG:JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46719", "l": "pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29114", "l": "H(+) + NADPH + ubiquinone-8 <=> NADP(+) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858289", "l": "MITF-M-dependent miR-211 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68954", "l": "Mcm2-7 is phosphorylated by DDK (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610752", "l": "GLI3R translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166015", "l": "Association of LBP with LPS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41994", "l": "5alpha-androstan-3,17-dione + H(+) + NADH => 17beta-hydroxy-5alpha-androstan-3-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36089", "l": "1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3244643", "l": "STING binds cyclic GMP-AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62358", "l": "8-oxo-GMP + H(+) + phosphate => 8-oxo-GDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.7", "l": "\"phosphopentomutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047290", "l": "alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity", "d": ["Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.10", "l": "\"chloride peroxidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769383", "l": "CBY1 binds beta-catenin (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.35", "l": "\"(R)-2-methylmalate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9761344", "l": "USP18 binds IKBKG within IKK complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-555065", "l": "Formation of clathrin coated vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51505", "l": "a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose => a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61074", "l": "(-)-(R)-19-O-acetyltabersonine + CoA => (-)-(R)-19-hydroxytabersonine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21775", "l": "cytidine(6666) in apoB mRNA + H(+) + H2O <=> NH4(+) + uridine(6666) in apoB mRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52654", "l": "eburicol + H(+) + S-adenosyl-L-homocysteine => lanosterol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73000", "l": "H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] => L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72631", "l": "Ca(2+)(in) + 3 Li(+)(out) = Ca(2+)(out) + 3 Li(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030338", "l": "CMP-N-acetylneuraminate monooxygenase activity", "d": ["Catalysis of the reaction: CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019810", "l": "putrescine binding", "d": ["Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000263", "l": "TCN2:RCbl is degraded to release RCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44345", "l": "ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide A + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19859", "l": "a 16-oxosteroid + H(+) + NADPH => a 16alpha-hydroxysteroid + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869542", "l": "TFPA2A homodimer and NPM1 bind the HSPD1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40333", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201622", "l": "Caspase-mediated cleavage of gelsolin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9761027", "l": "ZEB2 binds SP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948226", "l": "Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23599", "l": "H2O + 2 NAD(+) + UDP-alpha-D-glucose <=> 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030487", "l": "inositol-4,5-bisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050467", "l": "pentalenene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + pentalenene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25193", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-methylcatechol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448591", "l": "Interleukin-32 binds proteinase-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944233", "l": "Association of procollagen type XIX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22440", "l": "UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine = H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.18", "l": "\"UDP-galactose--UDP-N-acetylglucosamine galactose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60833", "l": "a 5'-end triphospho-guanosine in mRNA + H2O => a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53807", "l": "allodeoxycholoyl-CoA + ursodeoxycholate <=> allodeoxycholate + ursodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63800", "l": "GDP-alpha-D-mannose = GDP-beta-L-gulose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68016", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H2O = (2E,6E,10E)-geranylgeraniol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.218", "l": "\"morphine 6-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114684", "l": "Phosphorylation of Syntaxin-4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638104", "l": "UGCG transfers glucose to ceramide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78852", "l": "a long-chain 2,3-saturated fatty acyl-CoA + O2 => a long-chain (2E)-enoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76974", "l": "1-(9Z-octadecenoyl)-2-(7Z,10Z,13Z,16Z,19Z-docosapentaenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O <=> (9Z)-octadecenoate + 2-(7Z,10Z,13Z,16Z,19Z-docosapentaenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71137", "l": "H(+)(out) + L-histidine(in) + Na(+)(in) => H(+)(in) + L-histidine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322429", "l": "XIAP monoubiquinates TLE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39520", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61188", "l": "quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose = H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32635", "l": "linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.84", "l": "\"linalool 8-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70183", "l": "2 alpha-isomaltosyl-(1->4)-D-maltotriose = alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62264", "l": "hydrogencarbonate(out) + selenite(out) + Zn(2+)(out) = hydrogencarbonate(in) + selenite(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78341", "l": "5'-pGpA(2'-5') + H(+) => 2',3'-cGAMP + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40526", "l": "a quinone + succinate <=> a quinol + fumarate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22532", "l": "(2E)-octenedioyl-CoA + H2O = (3S)-hydroxyoctanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11624", "l": "2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate", "d": [], "t": []}, {"i": "EC:2.6.3.1", "l": "\"oximinotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57406", "l": "H(+) + NADH + noscapine => NAD(+) + narcotine hemiacetal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813740", "l": "GDE1 hydrolyzes GroPIns (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173725", "l": "C9 binds C5b:C6:C7:C8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696960", "l": "USP49 deubiquitinates H2B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46343", "l": "ATP + N-hexadecanoylsphing-4-enine <=> ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70836", "l": "L-arginine(in) + L-glutamine(out) + Na(+)(out) => L-arginine(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709878", "l": "BIL translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71687", "l": "glycyl-L-aspartate(out) + 2 H(+)(out) = glycyl-L-aspartate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63778", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024624", "l": "Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000099", "l": "sulfur amino acid transmembrane transporter activity", "d": ["Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106591", "l": "WWTR1:SMAD stimulates transcription of SMAD7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27596", "l": "all-trans-nonaprenyl diphosphate + 5 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033430", "l": "CGC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CGC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2752115", "l": "SPP1 (osteopontin) binds CD44 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59443", "l": "(-)-dehydrodiconiferyl alcohol + H(+) + NADPH <=> (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399952", "l": "Phosphorylation of LIMK-1 by PAK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53978", "l": "(14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65507", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + H2O <=> 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + [mycofactocin precursor peptide]-C-terminal glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20231", "l": "2,3-dihydroxybenzoyl-5'-AMP + diphosphate => 2,3-dihydroxybenzoate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15437", "l": "a long-chain fatty aldehyde + CoA + NADP(+) = a long-chain fatty acyl-CoA + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.50", "l": "\"long-chain-fatty-acyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.68", "l": "\"coniferyl-aldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654167", "l": "Activated FGFR1 binds PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102063", "l": "beta-curcumene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = diphosphoric acid + (-)-beta-curcumene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22087", "l": "(S)-2,3-diaminopropanoate + H(+) + H2O <=> 2 NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.858563584991252", "identifiers": [{"i": "GO:0030234", "l": "enzyme regulator activity", "d": ["Binds to and modulates the activity of an enzyme."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322427", "l": "Beta-catenin recruits CBP/p300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662781", "l": "CD163 gene produces CD163 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.178", "l": "\"2-dehydro-3-deoxyglucono/galactono-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36383", "l": "carbamoyl adenylate + tobramycin = AMP + H(+) + nebramycin 5'", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53666", "l": "H(+) + 2 H2O + pyridinestrone carboxylate => (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196857", "l": "PANK2 phosphorylates PanK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76771", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] = 1,3-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39909", "l": "dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761474", "l": "AMOT-2 binds CDH11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433451", "l": "JAK2 binds to p-KIT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844536", "l": "PPARA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73667", "l": "(E,E)-piperoyl-CoA + 2-methylpropan-1-amine = (E,E)-piperlonguminine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53760", "l": "allocholate + deoxycholoyl-CoA = allocholoyl-CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11417", "l": "2 1-O-galloyl-beta-D-glucose => 1,6-bis-O-galloyl-beta-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37194", "l": "2',3'-cyclophospho-AMP + H2O <=> adenosine 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983519", "l": "IL35 binds IL12RB2:IL12RB2 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42991", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> cembrene C + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13837", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.64", "l": "\"phthalate 4,5-cis-dihydrodiol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68512", "l": "(2Z,6Z)-farnesyl diphosphate = alpha-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2394007", "l": "PI3K gain of function mutants phosphorylate PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76203", "l": "n H(+)(out) + pyridoxine(out) = n H(+)(in) + pyridoxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45820", "l": "mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate", "d": [], "t": []}, {"i": "EC:2.8.3.26", "l": "\"succinyl-CoA:mesaconate CoA transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16515", "l": "acetate + CO2 + H2O => (S)-lactate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61304", "l": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45798", "l": "acetoacetyl-CoA + H(+) + NADPH => (3R)-3-hydroxybutanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30612", "l": "A + all-trans-zeta-carotene => AH2 + all-trans-neurosporene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39760", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466367", "l": "NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55291", "l": "tetradecan-1-ol + tetradecanoyl-CoA <=> CoA + tetradecanyl tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35423", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.298", "l": "\"anthocyanidin 3-O-glucoside 5-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870461", "l": "RABGGTA and RABGGTB bind (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42112", "l": "(20S)-hydroxypregn-4-en-3-one + NADP(+) = H(+) + NADPH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17669", "l": "3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.4", "l": "\"melilotate 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70062", "l": "a C27-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a (22S)-22-hydroxy C27-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209307", "l": "Phosphorylated STAT92E dimer activates transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734687", "l": "ORC6 is phosphorylated on T195 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008681", "l": "2-octaprenyl-6-methoxyphenol hydroxylase activity", "d": ["Catalysis of the reaction: 2-methoxy-6-(all-trans-octaprenyl)phenol + H+ + NADPH + O2 = 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11206", "l": "AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] => apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008855", "l": "exodeoxyribonuclease VII activity", "d": ["Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71181", "l": "FAH cleaves 4FAA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046987", "l": "N-acetyllactosamine beta-1,3-glucuronosyltransferase activity", "d": ["Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-D-glucuronic acid to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59587", "l": "ATP + beta-alanine + L-lysine <=> ADP + beta-alanyl-L-lysine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49922", "l": "(R)-carnitine(in) + O-octanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-octanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16464", "l": "ATP + H2O + urate(in) <=> ADP + H(+) + phosphate + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29964", "l": "H(+)(in) + inosine(in) => H(+)(out) + inosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004145", "l": "diamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70975", "l": "CS acetylates OA to citrate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15705", "l": "2 a ubiquinone + H2O + phenylacetyl-CoA = 2 a ubiquinol + phenylglyoxylyl-CoA", "d": [], "t": []}, {"i": "EC:1.17.5.1", "l": "\"phenylacetyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44654", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18525", "l": "3-methylbutanol + NADP(+) = 3-methylbutanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62937", "l": "H2O + N(4)-acetyl-2'-deoxycytidine => 2'-deoxycytidine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43473", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0003990", "l": "acetylcholinesterase activity", "d": ["Catalysis of the reaction: acetylcholine + H2O = choline + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64238", "l": "atrochrysone carboxylate + H(+) + holo-[ACP] => atrochrysone carboxyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140312", "l": "cargo adaptor activity", "d": ["Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71118", "l": "H(+) + hispidin + NADH + O2 <=> 3-hydroxyhispidin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64277", "l": "chrysophanol-9-anthrone + O2 => chrysophanol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77655", "l": "2-[(1R,8S,14R,15R)-11-hydroxy-14,15-bis[(6E)-oct-6-en-1-yl]-3,5,9-trioxo-4,10-dioxatetracyclo[9.4.0.0(2,6).0(8,12)]pentadeca-2(6),12-dien-8-yl]acetate + 3 2-oxoglutarate + 3 O2 = 3 CO2 + H2O + phomoidride A + 3 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12163", "l": "2-deoxy-D-gluconate + NAD(+) <=> 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29256", "l": "Ca(2+)(in) + Na(+)(out) => Ca(2+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68952", "l": "isoscopoletin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + scoparone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77566", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol <=> 1-(9Z-octadecenoyl)-3-hexadecanoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19320", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate <=> 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10451", "l": "2-oxoglutarate + a flavanone + O2 <=> a flavone + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43900", "l": "dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O = beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23939", "l": "D-gluconate + NADP(+) <=> 5-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102280", "l": "choline monooxygenase (NADP+) activity", "d": ["Catalysis of the reaction: choline + NADP+ = betaine aldehyde + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44662", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034022", "l": "3-(hydroxyamino)phenol mutase activity", "d": ["Catalysis of the reaction: 3-hydroxyaminophenol = aminohydroquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008788", "l": "alpha,alpha-phosphotrehalase activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56006", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848414", "l": "Activated PTK6 binds CDKN1B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429497", "l": "SLP-76 stimulates PLC gamma 2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013143", "l": "RAC1 GEFs activate RAC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58261", "l": "H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] => ADP-D-ribose + L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46202", "l": "5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18020", "l": "H(+) + indole-3-pyruvate <=> CO2 + indole-3-acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37224", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34008", "l": "7-dehydrodesmosterol + S-adenosyl-L-methionine => 5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062101", "l": "peptidyl-aspartic acid 3-dioxygenase activity", "d": ["Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102368", "l": "beta-amyrin 30-monooxygenase activity", "d": ["Catalysis of the reaction: beta-amyrin + NADPH + H+ + O2 = 30-hydroxy-beta-amyrin + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033428", "l": "CAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CAG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74931", "l": "2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2 = a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4837364", "l": "Secretion of SOD3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4167511", "l": "HLCS biotinylates ACACB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60388", "l": "Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30950", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-gamma-eudesmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709406", "l": "CO binds to Cytochrome c oxidase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008564", "l": "protein-exporting ATPase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940561", "l": "MMP7 cleaves OPTC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851710", "l": "Aberrant alternative splicing yields a secreted FGFR2 IIIa TM disease variant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47385", "l": "4-acetoxyphenol + H2O => acetate + H(+) + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12807", "l": "(S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine => (S)-canadine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0005363", "l": "maltose transmembrane transporter activity", "d": ["Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch."], "t": []}, {"i": "RHEA:33171", "l": "D-maltose(in) = D-maltose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25898", "l": "acetate + CO2 => H(+) + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38571", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67731", "l": "DNA(n) + dZTP <=> diphosphate + DNA(n)-Z", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13842", "l": "Fe(II)2-[transferrin] + H(+) + NAD(+) => Fe(III)2-[transferrin] + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174202", "l": "Degradation of multiubiquitinated Securin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624112", "l": "CEBPA binds CDK4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626681", "l": "Recruitment of transition zone proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869580", "l": "DEK binds TFAP2A homodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56757", "l": "5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] => 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76728", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 7-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937369", "l": "ATAD2 binds ESR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41141", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32341", "l": "(+)-thujan-3-one + H(+) + NADPH => (+)-thujan-3-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65162", "l": "CoA + hexan-2-yl benzoate => benzoyl-CoA + hexan-2-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692241", "l": "Expression of SRY in testis differentiation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15973", "l": "3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.4", "l": "\"estrone sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56087", "l": "[Rab1 protein]-O-phosphocholine-L-serine + H2O <=> [Rab1 protein]-L-serine + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664879", "l": "ATM:PEX5 binds ATM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37965", "l": "D-galactose + H(+) + NADH => galactitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37021", "l": "3-hydroxypyruvate + AH2 + NH4(+) => A + D-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614605", "l": "Persulfide sulfur is dioxygenated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950575", "l": "IL12A:IL12B translocates from ER lumen to Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75095", "l": "2 chloride(in) + oxalate(out) = 2 chloride(out) + oxalate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51080", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50781", "l": "NADP(+) + octanal => (2E)-octenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1878002", "l": "XYLTs transfer Xyl to core protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667761", "l": "KCNMA1:KCNMB1:LRRC52 transports K+ from the cytosol to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336184", "l": "GPR37L binds prosaposin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0015379", "l": "potassium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036373", "l": "L-fucose mutarotase activity", "d": ["Catalysis of the reaction: alpha-L-fucose = beta-L-fucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388833", "l": "Phosphorylation of CTLA-4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140398", "l": "versicolorin B desaturase activity", "d": ["Catalyzes the reaction: versicolorin B + NADPH + O2 = versicolorin A + NADP+ + 2 H2O. Uses heme-thiolate as a co-factor. Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34454", "l": "dTDP-6-deoxy-beta-L-talose <=> dTDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034862", "l": "2,6-dihydroxybenzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 2,6-dihydroxybenzothiazole + 1/2 O2 = 2,6,7-trihydroxybenzothiazole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350186", "l": "CUBN binds GC:25(OH)D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731274", "l": "nsp16 localizes to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50090", "l": "21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39485", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+) => 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693599", "l": "Association of Ku heterodimer with ends of DNA double-strand break (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373087", "l": "Receptor CCR6 binds CCL20 ligand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75785", "l": "ADP(out) => ADP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62708", "l": "(indol-3-yl)butanoate + UDP-alpha-D-glucose = 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21831", "l": "H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22243", "l": "H2O + methylenediurea <=> N-(carboxyaminomethyl)urea + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24274", "l": "H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+) => H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66223", "l": "asc-omegaC7-CoA + O2 <=> asc-omegaDeltaC7-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874082", "l": "MET phosphorylates PTK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43100", "l": "S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.211", "l": "\"tRNA(Ser) (uridine(44)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31458", "l": "NAD(+) + reduced riboflavin <=> 2 H(+) + NADH + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68096", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + a 5'-end 5'-phospho-ribonucleoside-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061749", "l": "forked DNA-dependent helicase activity", "d": ["Unwinding a DNA helix containing forked DNA, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72064", "l": "glycoursodeoxycholate(out) + 2 Na(+)(out) => glycoursodeoxycholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66166", "l": "CoA + H(+) + N-butanoylserotonin => butanoyl-CoA + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48601", "l": "[protein-PII]-uridylyl-L-tyrosine + H2O => [protein-PII]-L-tyrosine + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63806", "l": "GDP-beta-L-galactose => GDP-beta-L-gulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44837", "l": "a globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose => a globoside NOR2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77589", "l": "Recognition of AAUAAA sequence by CPSF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32917", "l": "sn-glycero-3-phospho-1D-myo-inositol(in) => sn-glycero-3-phospho-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795290", "l": "TORC2 complex phosphorylates SGK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72023", "l": "nicotinate(in) + urate(out) = nicotinate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24844", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O = 2 isomaltose", "d": [], "t": []}, {"i": "EC:3.2.1.204", "l": "\"1,3-alpha-isomaltosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42593", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217136", "l": "Phosphorylation of Chk1 by ATM upon DNA damage (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57895", "l": "a quinone + 5 H(+)(in) + NADPH <=> a quinol + 4 H(+)(out) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76604", "l": "(12Z)-10-hydroxyoctadecenoate + H2O => 10,13-dihydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18267", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH => 6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046547", "l": "trans-aconitate 3-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77846", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-tyrosine + O2 <=> 2-dehydro-D-glucose + H2O2 + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45129", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70701", "l": "H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in) => H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198298", "l": "AKT translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65118", "l": "aculene A + CO2 + H2O + succinate => 2-oxoglutarate + aculene B + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202703", "l": "CD47 binds SIRP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9860290", "l": "TASL recruits IRF5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43738", "l": "H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine => adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69180", "l": "ADP + thiamine diphosphate = AMP + thiamine triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071972", "l": "peptidoglycan L,D-transpeptidase activity", "d": ["Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65856", "l": "A + a 1-hydroxy-3-oxo steroid = a steroid 1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77939", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9670014", "l": "Factor VIIIa dissociates  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35153", "l": "(3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH => 4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13719", "l": "1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH => 2-C-methyl-D-erythritol 4-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13549", "l": "beta-L-fucose 1-phosphate + GTP + H(+) = diphosphate + GDP-beta-L-fucose", "d": [], "t": []}, {"i": "EC:2.7.7.30", "l": "\"fucose-1-phosphate guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68940", "l": "Na(+)(in) + tellurite(in) = Na(+)(out) + tellurite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28527", "l": "(R)-carnitine + crotonobetainyl-CoA => (R)-carnitinyl-CoA + crotonobetaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450187", "l": "TAK1 is activated within the TAK1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45570", "l": "[acharan](n) => [heparosan](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13235", "l": "alpha-D-ribose 1-phosphate + guanine => guanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955794", "l": "PGP:Mg2+ dimer hydrolyses 3PG to glycerol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14496", "l": "H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] <=> ADP-D-ribose + L-arginyl-[dinitrogen reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.60", "l": "\"scutelarin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168638", "l": "Activated IKK phosphorylates I-kappaB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61731", "l": "a 3-dehydro-D-guloside <=> a 3-dehydro-D-glucoside", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63084", "l": "chloride + FADH2 + ilicicolin B + O2 = FAD + H(+) + 2 H2O + ilicicolin A", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74278", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A <=> a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004900", "l": "erythropoietin receptor activity", "d": ["Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047996", "l": "hydroxyphytanate oxidase activity", "d": ["Catalysis of the reaction: (2S)-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199203", "l": "PANK1/3 phosphorylate PanK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34556", "l": "a (2S)-2-hydroxycarboxylate + NAD(+) => a 2-oxocarboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9861734", "l": "PDH E1 decarboxylates PYR, transferring acetyl to DLAT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0097157", "l": "pre-mRNA intronic binding", "d": ["Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821412", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35486", "l": "5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15183", "l": "ADP + an acyl-CoA(in) + H(+) + phosphate => an acyl-CoA(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12620", "l": "ATP + N-acetyl-alpha-D-galactosamine <=> ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6804099", "l": "HMGB1 binds LTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9652264", "l": "ERBB2 binds TKIs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10629", "l": "phosphate + tRNA(n+1) => a ribonucleoside 5'-diphosphate + tRNA(n)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34736", "l": "a fatty acyl-CoA + sphinganine => an N-acylsphinganine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37931", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33783", "l": "1(F)-beta-D-fructosylsucrose + sucrose = 1,6-kestotetraose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71819", "l": "L-thyroxine(out) = L-thyroxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56164", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50861", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46075", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADH <=> hexadecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68838", "l": "(6R,7S)-himachala-9,11-diene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38897", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38094", "l": "delta-tocotrienol + S-adenosyl-L-methionine <=> beta-tocotrienol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34980", "l": "H(+)(in) => H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78873", "l": "a very-long-chain 3-oxoacyl-CoA + H(+) + NADH => a very-long-chain (3R)-3-hydroxyacyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806732", "l": "GNLY binds the bacterial cell surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944254", "l": "Association of procollagen type XXVI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9825751", "l": "HINT1 binds MITF-M (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807106", "l": "PTEN undergoes monoubiquitination (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23830", "l": "2,5-didehydro-D-gluconate + H(+) + NADPH => 2-dehydro-D-gluconate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853496", "l": "SCF:FBXL7 binds AURKA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202714", "l": "CD58 binds CD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483174", "l": "PE is methylated to PC by PEMT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59660", "l": "D-cellotetraose + O2 = D-cellotetraono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58264", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15967", "l": "1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69784", "l": "(2-aminophenyl)succinate + succinyl-CoA => 2-(2-aminophenyl)succinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9842665", "l": "Active LTK binds GRB2:TNK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24159", "l": "2-methylpropanoate + ATP <=> 2-methylpropanoyl phosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31667", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.89", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607721", "l": "Activation of NIK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23799", "l": "17-O-acetylnorajmaline + H2O <=> acetate + H(+) + norajmaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35116", "l": "4-coumaroyl-CoA + H(+) + malonyl-CoA => (4-coumaroyl)acetyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42562", "l": "pseudouridine(27/28) in mitochondrial tRNA => uridine(27/28) in mitochondrial tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879594", "l": "SLCO4C1 mediates the transport of digoxin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32843", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol = a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53338", "l": "H(+) + NADPH + uridine(20) in tRNA => 5,6-dihydrouridine(20) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71968", "l": "(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) => (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749215", "l": "MCM8 binds CDC6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38999", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75738", "l": "10-oxo-(12Z)-octadecenoate <=> 10-oxo-(11E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74885", "l": "GUCYs converts GTP to cGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954117", "l": "E2F6:TFDP1 binds EPC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15769", "l": "adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22124", "l": "17-O-acetylajmaline + H2O = acetate + ajmaline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56219", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44561", "l": "4-hydroxybenzoate + all-trans-heptaprenyl diphosphate => 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43156", "l": "guanosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.221", "l": "\"tRNA (guanine(9)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.119", "l": "\"kallikrein 13\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74990", "l": "erythrostominone(in) <=> erythrostominone(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201519", "l": "ALK:PTN dimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45886", "l": "4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74355", "l": "a cytidine in mRNA + H(+) + H2O = a uridine in mRNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427514", "l": "eNoSC deacetylates histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72036", "l": "ATP(out) + 2 H(+)(out) + phosphate(in) => ATP(in) + 2 H(+)(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626945", "l": "CREBBP acetylates FOXO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.44", "l": "\"cinnamoyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30939", "l": "ATP + dIDP = ADP + dITP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047513", "l": "1,2-alpha-L-fucosidase activity", "d": ["Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102692", "l": "benzyladenine UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine = H+ + N-benzyl-9-(alpha-D-glucosyl)adenine + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474266", "l": "Formation of collagen fibrils (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831714", "l": "M forms a homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018733", "l": "3,4-dihydrocoumarin hydrolase activity", "d": ["Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11332", "l": "ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide", "d": [], "t": []}, {"i": "EC:2.7.7.19", "l": "\"polynucleotide adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57866", "l": "4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380216", "l": "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60582", "l": "18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52594", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH => deoxycholoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78959", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69315", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate <=> benzyl thiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011966", "l": "Estrogen-responsive KDM4B gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40269", "l": "3-oxohexadecanedioyl-CoA + H(+) + NADH => (3S)-hydroxyhexadecanedioyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53268", "l": "L-ribulose = L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59597", "l": "H2O + kynuramine + O2 => 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614773", "l": "MBP gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20072", "l": "(Z)-phenylacetaldehyde oxime <=> H2O + phenylacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18033", "l": "benzoate + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.92", "l": "\"benzoate 4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007926", "l": "ATRX binds DAXX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37862", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA <=> 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52256", "l": "a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77591", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol = 1-(9Z-octadecenoyl)-3-(9Z,12Z-octadecadienoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73273", "l": "H(+) + rhamnacene + S-adenosyl-L-homocysteine => rhamnetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381727", "l": "RAP1A exchanges GDP for GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0070001", "l": "aspartic-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61942", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0008486", "l": "diphosphoinositol-polyphosphate diphosphatase activity", "d": ["Catalysis of the reaction: diphospho-1D-myo-inositol polyphosphate + H2O = 1D-myo-inositol polyphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58398", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NH4(+) + 4 oxidized [2Fe-2S]-[ferredoxin] => 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + 5 H(+) + O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211950", "l": "CYP24A1 24-hydroxylates CTL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637795", "l": "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635102", "l": "GPR161 is internalized (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10708", "l": "alpha-D-glucose 1-phosphate + GTP + H(+) = diphosphate + GDP-D-glucose", "d": [], "t": []}, {"i": "EC:2.7.7.34", "l": "\"glucose-1-phosphate guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13092", "l": "6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) <=> 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052909", "l": "18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity", "d": ["Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48387", "l": "a 2,3-saturated fatty acid + H2O2 <=> a 3-hydroxy fatty acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36113", "l": "O-methyl gibberellin A1 + S-adenosyl-L-homocysteine => gibberellin A1 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78582", "l": "(3R)-hydroxydocosanoyl-CoA + NAD(+) <=> 3-oxodocosanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33539", "l": "ergosteryl ester + H2O = a carboxylate + ergosterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45382", "l": "(4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18328", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-amorpha-4,11-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15894", "l": "Co-sirohydrochlorin + 2 H(+) => Co(2+) + sirohydrochlorin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16136", "l": "H2O + N(1)-acetylspermine + O2 <=> 3-aminopropanal + H2O2 + N(1)-acetylspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52961", "l": "hyocholate + UDP-alpha-D-glucuronate => hyocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561072", "l": "OCT3 mediates renal uptake of organic cations (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44297", "l": "2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA => 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1449687", "l": "Corticosteroids bind to CBG in blood (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52261", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide c => a bacteriochlorophyllide e + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44039", "l": "12,13-epoxy-(9Z)-octadecenoate + H2O <=> 12,13-dihydroxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15122", "l": "dithioerythritol + thiosulfate => cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30824", "l": "UDP-N-acetyl-alpha-D-glucosamine => H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61205", "l": "L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal => H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824986", "l": "XPO1-dependent export of p-S69,S73 MITF-M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77055", "l": "cyclopentylamine + H2O + NADP(+) = cyclopentanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665409", "l": "GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102641", "l": "(R)-lactaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-propane-1,2-diol + NADP = (R)-lactaldehyde + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70173", "l": "H(+)(out) + pemetrexed(out) => H(+)(in) + pemetrexed(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75457", "l": "(13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140831", "l": "L-asparagine, sodium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-asparagine(out) + Na+(out) = H+(out) + L-asparagine(in) + Na+(in)."], "t": []}, {"i": "RHEA:71131", "l": "H(+)(in) + L-asparagine(out) + Na(+)(out) = H(+)(out) + L-asparagine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392513", "l": "Rap1 signal termination by Rap1GAPs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376884", "l": "glucose 6-phosphate [cytosol] => glucose 6-phosphate [endoplasmic reticulum lumen] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8867344", "l": "OMA1 hydrolyses OPA1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29055", "l": "a ubiquinone + 2 H(+)(in) + H2 = a ubiquinol + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35202", "l": "(S,S)-tartrate(out) <=> (S,S)-tartrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2314678", "l": "ASA- acetylates PTGS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45892", "l": "an N-acylsphing-4-enine + CDP-ethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997237", "l": "SH2B proteins bind JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14744", "l": "4-methylene-L-glutamine + H2O <=> 4-methylene-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39309", "l": "(11Z,14Z)-eicosadienoyl-CoA + NADP(+) => (2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001691", "l": "pseudophosphatase activity", "d": ["Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26120", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13701", "l": "acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine", "d": [], "t": []}, {"i": "EC:2.3.1.31", "l": "\"homoserine O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56769", "l": "2 AH2 + all-trans-zeaxanthin + 2 O2 => 2 A + all-trans-adonixanthin + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79094", "l": "an L-alpha-amino acid + taurocholate <=> an N-choloyl-L-alpha-amino acid + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32093", "l": "dTDP + erythromycin D + H(+) => 3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74075", "l": "H(+) + NADH + phylloquinone = NAD(+) + phylloquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196773", "l": "COASY phosphorylates DP-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984001", "l": "IL35 binds IL27RA:IL12RB2 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25280", "l": "3',5'-cyclic AMP + H2O <=> AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11941", "l": "2 H(+) + H2O + L-citrulline => CO2 + L-ornithine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13056", "l": "L-phenylalanine + pyruvate <=> 3-phenylpyruvate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389463", "l": "Proteinase-activated receptors can bind thrombin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14533", "l": "creatinine + H2O = creatine", "d": [], "t": []}, {"i": "EC:3.5.2.10", "l": "\"creatininase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33876", "l": "cholesteryl (9Z-octadecenoate) + H2O => (9Z)-octadecenoate + cholesterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46602", "l": "[HPr protein]-O-phospho-L-serine + ADP + H(+) => [HPr protein]-L-serine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18840", "l": "10-deacetyltaxuyunnanin C + acetyl-CoA <=> CoA + taxuyunnanin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74512", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B => aspoquinolone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.71", "l": "\"arylamine glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602473", "l": "Autocatalytic activation of MMP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034939", "l": "5-hydroxypyrrole-2-carboxylate tautomerase activity", "d": ["Catalysis of the reaction: 5-hydroxypyrrole-2-carboxylate = 5-oxo-4,5-dihydropyrrole-2-carboxylate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937792", "l": "RUNX3 binds SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327746", "l": "FN1 aggregation (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78195", "l": "a 3beta-hydroxysteroid + a triacylglycerol = a 1,2-diacylglycerol + a 3beta-hydroxysteroid ester", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56648", "l": "3-oxochol-4-en-24-oyl-CoA + NAD(+) = 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008868", "l": "galactitol-1-phosphate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: galactitol-1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607753", "l": "CARD9 oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209129", "l": "Ubiquitinated and phosphorylated ARM binds to and is degraded by the proteasome complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69076", "l": "(R)-noradrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.99.-", "l": "\"Other protein kinases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31235", "l": "(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate = (4R)-4-hydroxy-2-oxoglutarate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.23", "l": "\"4-hydroxyglutamate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71218", "l": "2 Na(+)(out) + thiocyanate(out) <=> 2 Na(+)(in) + thiocyanate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56661", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33156", "l": "a 1-acyl-sn-glycero-3-phosphate + H2O => a 1-acyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33126", "l": "all-trans-heptaprenyl diphosphate <=> (R)-tetraprenyl-beta-curcumene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77160", "l": "H2O + selenophosphate + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-1-seleno-beta-D-glucosamine + phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71947", "l": "N-acetyl-L-aspartate(out) + 3 Na(+)(out) = N-acetyl-L-aspartate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636457", "l": "SapM dephosphorylates PI3P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50829", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31386", "l": "(S)-2,3-epoxysqualene <=> lupeol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24530", "l": "H(+) + methylglyoxal + NADH => (R)-lactaldehyde + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41842", "l": "(3R)-hydroxyoctanoyl-[ACP] + NADP(+) => 3-oxooctanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196417", "l": "Reduction of desmosterol to cholesterol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74266", "l": "n H(+)(out) + spermine(in) <=> n H(+)(in) + spermine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66222", "l": "asc-omegaDeltaC7-CoA + H2O2 => asc-omegaC7-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10365", "l": "2-oxoglutarate + dodecanoyl-CoA + H2O => (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793666", "l": "MDM2 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51942", "l": "(1Z,2S)-2-methylbutanal oxime => (1E,2S)-2-methylbutanal oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31822", "l": "(2E,6E)-farnesyl diphosphate <=> 5-epi-alpha-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67631", "l": "ATP + dGMP + L-aspartate <=> (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20444", "l": "L-cysteine + O2 <=> 3-sulfino-L-alanine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47248", "l": "2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone = 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52446", "l": "2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41919", "l": "H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] <=> 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61592", "l": "H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine = 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine", "d": [], "t": []}, {"i": "EC:1.8.98.7", "l": "\"cysteine-type anaerobic sulfatase-maturating enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32095", "l": "acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.197", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2219524", "l": "PDPK1 binds PIP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804383", "l": "PRMT5 methylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018759", "l": "methenyltetrahydromethanopterin cyclohydrolase activity", "d": ["Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211968", "l": "CYP2W1 oxidises INDOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769401", "l": "DKK and KRM bind LRP5/6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362465", "l": "GHBP binds GHR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31149", "l": "3,4-dihydroxymandelaldehyde + H(+) + NADH => 3,4-dihydroxyphenylethyleneglycol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004919", "l": "interleukin-9 receptor activity", "d": ["Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102631", "l": "caffeoylglucose 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: 1-O-caffeoyl-beta-D-glucose + S-adenosyl-L-methionine = 1-O-feruloyl-beta-D-glucose + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977250", "l": "Autophosphorylation of IRAK4 bound to activated TLR5 or 15 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46996", "l": "6-hydroxy-N-methylmyosmine + H2O = 6-hydroxypseudooxynicotine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033824", "l": "alternansucrase activity", "d": ["Catalysis of the transfer of an alpha-D-glucosyl residue from sucrose to alternately the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-1,6- and alpha-1,3-linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9670014", "l": "Factor VIIIa dissociates  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55124", "l": "(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH = 5-methylhexanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035615", "l": "clathrin adaptor activity", "d": ["Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30468", "l": "(2Z,6Z)-farnesyl diphosphate => (+)-endo-beta-bergamotene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50186", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9860295", "l": "SLC15A4 binds TASL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693783", "l": "NAALADases hydrolyse NAAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37893", "l": "15-demethylaclacinomycin T + methanol => aclacinomycin T + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66123", "l": "2-oxobutanoate + L-methionine <=> (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66394", "l": "ADP + H(+) + phosphate + prostaglandin E1(out) => ATP + H2O + prostaglandin E1(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25594", "l": "2-oxoglutarate + H(+) + isochorismate => 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45935", "l": "2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016680", "l": "oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP."], "t": []}, {"i": "EC:1.10.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942302", "l": "MMP13 cleaves OPTC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251942", "l": "Hikeshi binds HSP70s:ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57439", "l": "guaethol + O2 + reduced [NADH--hemoprotein reductase] <=> acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140802", "l": "NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: [protein]-C-terminal glycine + NAD+ = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide."], "t": []}, {"i": "RHEA:58268", "l": "[protein]-C-terminal glycine + NAD(+) = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019166", "l": "trans-2-enoyl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.256", "l": "\"fluoren-9-ol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67717", "l": "NADPH + 2 oxidized [2Fe-2S]-[protein] => H(+) + NADP(+) + 2 reduced [2Fe-2S]-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70483", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2 = a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68784", "l": "(2Z,6Z)-farnesyl diphosphate = diphosphate + gamma-curcumene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23810", "l": "(S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine => (S)-scoulerine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65663", "l": "A + calciol + H2O <=> AH2 + calcidiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60412", "l": "H2O + monoglucosyl-enterobactin = [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176318", "l": "Loading of claspin onto DNA during replication origin firing (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391865", "l": "Recruitment of FAK to NCAM1:Fyn in lipid rafts (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75100", "l": "(4Z,15Z)-bilirubin IXalpha + UDP-alpha-D-glucuronate => (4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66466", "l": "scalarane-17alpha-19-diol => (2E,6E,10E,14E)-geranylfarnesol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139941", "l": "Binding of IP3 to IP3 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010859", "l": "calcium-dependent cysteine-type endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49990", "l": "H2O + methyl acetate + NADP(+) => acetone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64822", "l": "2-phenylacetate + NH4(+) => 2-phenylacetamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429157", "l": "ABCC4 accumulation of dense granule contents (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102371", "l": "betulin dehydrogenase activity", "d": ["Catalysis of the reaction: betulin + NADPH(4-) + H+ + O2 = betulinic aldehyde + NADP(3-) + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47931", "l": "(2S)-3-sulfolactaldehyde + H2O + NADP(+) <=> (2S)-3-sulfolactate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102086", "l": "N-vanillate-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: vanillate + L-glutamate(1-) + ATP = H+ + N-vanillate-L-glutamate + AMP + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40282", "l": "(R)-carnitine + dodecanoyl-CoA <=> CoA + O-dodecanoyl-R-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49480", "l": "2 H2O + L-1-piperideine-6-carboxylate + NADP(+) = H(+) + L-2-aminoadipate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65599", "l": "4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43107", "l": "AH2 + an N-acyleicosasphinganine + O2 <=> A + an N-acyleicosasphing-4-enine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430308", "l": "PARVB interacts with Alpha-actinin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.8", "l": "\"guanylate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018774", "l": "2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity", "d": ["Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35540", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + O2 => albonoursin + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64442", "l": "glycylglycyl-L-proline(in) + H(+)(in) => glycylglycyl-L-proline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78915", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA = a long-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8878654", "l": "ACP6 hydrolyses MYS-LPA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12577", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose => (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167098", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681616", "l": "AP2 binds chlorpromazine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19622", "l": "a nucleoside 2',3'-cyclic phosphate + H2O => a nucleoside 3'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006873", "l": "IL21 receptor STAT binding (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174551", "l": "Formation of alternative pathway C5 convertase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64152", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77665", "l": "1-O-alkyl-2,3-diacylglycerol + CoA => 1-O-alkyl-3-acylglycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629154", "l": "NEIL1 recognizes and binds thymine glycol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36236", "l": "1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130151", "l": "Dimerization of DAP12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16290", "l": "(1R,2S)-ephedrine + NAD(+) => (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878056", "l": "RUNX1:CBFB binds EP300 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12271", "l": "2-oxoglutarate + putrescine <=> 1-pyrroline + H2O + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636658", "l": "esxA binds PGK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418456", "l": "cGMP is degraded by PDEs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72873", "l": "anthocyanin A5 + CoA => anthocyanin A3 + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35191", "l": "noranthrone + O2 = H2O + norsolorinic acid", "d": [], "t": []}, {"i": "EC:1.13.12.20", "l": "\"noranthrone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47180", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) = (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51026", "l": "4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+) => H(+) + NADH + O2 + toluene-4-sulfonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33451", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] = AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56008", "l": "4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033990", "l": "ectoine synthase activity", "d": ["Catalysis of the reaction: N(4)-acetyl-L-2,4-diaminobutyrate = ectoine + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690493", "l": "RHOB binds effectors on endosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11843", "l": "benzaldehyde + H2O + NAD(+) <=> benzoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450474", "l": "MK2 phosphorylates BRF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638845", "l": "CERK phosphorylates CERA to form C1P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710106", "l": "ELANE cleaves GSDMD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030766", "l": "11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168412", "l": "MDP elicits a NOD2 response (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035888", "l": "isoguanine deaminase activity", "d": ["Catalysis of the reaction: isoguanine + H2O = xanthine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062057", "l": "L-aspartate:fumarate antiporter activity", "d": ["Enables the transport of L-aspartate and fumarate across a membrane according to the reaction L-aspartate (out) + fumarate (in) = L-aspartate (in) + fumarate (out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160148", "l": "tRNA pseudouridine(55) synthase activity", "d": ["Catalysis of the reaction: uridine(55) in tRNA = pseudouridine(55) in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0086075", "l": "gap junction channel activity involved in cardiac conduction electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66579", "l": "3'-phosphoadenylyl sulfate + 4-isopropylphenol <=> 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828720", "l": "SH mRNA is translated into protein SHt (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39260", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA => (2E,13Z)-docosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60679", "l": "(S)-(-)-citronellol + NAD(+) <=> (S)-(-)-citronellal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15436", "l": "(2S)-naringenin + dimethylallyl diphosphate <=> diphosphate + sophoraflavanone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74885", "l": "GUCYs converts GTP to cGMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64978", "l": "8-oxo-dGMP + 2 H(+) + 2 phosphate => 8-oxo-dGTP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15463", "l": "3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44980", "l": "(R)-carnitine + butanoyl-CoA = CoA + O-butanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19467", "l": "H(+) + NADP(+) + 2 nitrate => NADPH + 2 nitric oxide + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59679", "l": "D-maltotetraose + O2 <=> D-maltotetraono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046569", "l": "glyoxal oxidase activity", "d": ["Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13028", "l": "3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] <=> 3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139917", "l": "tBID activates BAX protein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36152", "l": "(E)-cinnamyl alcohol + acetyl-CoA => (E)-cinnamyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63215", "l": "5-amino-6-(D-ribitylamino)uracil + methylglyoxal <=> 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51579", "l": "phloretin + UDP-alpha-D-glucose <=> H(+) + phlorizin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9676160", "l": "AAMP binds NOD2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691150", "l": "TFR2 dimer binds 2xholoTF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62008", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68609", "l": "H(+) + isatin + NADPH => 3-hydroxyindolin-2-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50599", "l": "acetyl-CoA + N-terminal L-seryl-[histone H4] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825751", "l": "HINT1 binds MITF-M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75849", "l": "SLC25A1 exchanges CIT and MAL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735505", "l": "Expression of SRF in cardiogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63917", "l": "5-fluorouridine + ATP => 5-fluorouridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018621", "l": "4-sulfobenzoate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 4-sulfobenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + NAD+ + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381727", "l": "RAP1A exchanges GDP for GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112037", "l": "Inactivation of PLC beta (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25722", "l": "H(+) + N,N-dihydroxy-L-trihomomethionine <=> (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36406", "l": "a cholesterol ester + H2O <=> a fatty acid + cholesterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20591", "l": "(2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein] => glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49796", "l": "an N-(fatty acyl)-glycine + H2O = a fatty acid + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210430", "l": "Release of L-Glutamate at the synapse (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75763", "l": "(9E,11E)-octadecadienoate + H2O = 10-hydroxy-(11E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45363", "l": "H2O + N-(11Z-eicosenoyl)-sphinganine <=> (11Z)-eicosenoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050341", "l": "thymine dioxygenase activity", "d": ["Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854052", "l": "Formation of the SCF-FBXL7 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193656", "l": "p75NTR interacts with RIP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49501", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008036", "l": "RUNX2 binds to HIVEP3 and WWP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696274", "l": "RND1 binds GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27948", "l": "3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+) => dopamine + H2O + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66046", "l": "(2S)-2-aminobutanoate + H2O + kynurenate => 2-oxobutanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32468", "l": "2 S-adenosyl-L-methionine + sarcosine => glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59976", "l": "2-phenylacetate + H(+) = CO2 + toluene", "d": [], "t": []}, {"i": "EC:4.1.1.119", "l": "\"phenylacetate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62711", "l": "(indol-3-yl)butanoate + UDP-alpha-D-glucose <=> 4-(indol-3-yl)butanoyl-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990473", "l": "ciliary targeting signal binding", "d": ["Binding to a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11065", "l": "beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53256", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024386", "l": "Oxysterol-induced binding of NR1H2,3:RXR to the ABCG1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29590", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) <=> 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35933", "l": "3''-deamino-3''-hydroxykanamycin X + H(+) + UDP => 2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70186", "l": "2 alpha-isomaltosyl-(1->4)-D-maltotriose <=> alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24976", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682629", "l": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53431", "l": "a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] <=> a thymidine in DNA + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902052", "l": "(25S)-Delta(7)-dafachronate binding", "d": ["Binding to (25S)-Delta(7)-dafachronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55060", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] = a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651789", "l": "LIG1 bound to POLB ligates SSB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114284", "l": "Release of Cytochrome c from mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951727", "l": "cAMP binds PKA tetramer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58326", "l": "cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine => beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14812", "l": "phenol + S-adenosyl-L-methionine <=> anisole + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003961", "l": "O-acetylhomoserine aminocarboxypropyltransferase activity", "d": ["Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43097", "l": "guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218852", "l": "p-6Y-VEGFR2 binds PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451481", "l": "TLR7 binds to recognized ligands (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31668", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose => dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13721", "l": "H2O + testololactone = H(+) + testolate", "d": [], "t": []}, {"i": "EC:3.1.1.37", "l": "\"steroid-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646295", "l": "p14ARF mutant does not translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429955", "l": "CCR4-NOT complex deadenylates mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40476", "l": "1,2,3-tributanoylglycerol + H2O => butanoate + dibutanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67259", "l": "H2O + NAD(+) + propanal <=> 2 H(+) + NADH + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033188", "l": "sphingomyelin synthase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14024", "l": "AH2 + ecdysone + O2 <=> 20-hydroxyecdysone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.152", "l": "\"mannosylglycoprotein endo-beta-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19851", "l": "ADP-D-ribose 2'-phosphate + H(+) + nicotinamide => H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35340", "l": "3-hydroxyicosanoyl-CoA + NADP(+) => 3-oxoeicosanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0051998", "l": "protein carboxyl O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to a carboxyl group on a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21215", "l": "H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] <=> 4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60752", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone = CoA + jasmolin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428690", "l": "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62105", "l": "(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509827", "l": "ITPA hydrolyses ITP to IMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106330", "l": "sialate 9-O-acetylesterase activity", "d": ["Catalysis of the reaction: H2O + N-acetyl-9-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate."], "t": []}, {"i": "RHEA:22600", "l": "H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67394", "l": "2-oxo-AMP + diphosphate + H(+) => 2-oxo-ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61738", "l": "rubusoside + UDP => steviolmonoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30730", "l": "dATP + pyruvate <=> dADP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70584", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44509", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32862", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71539", "l": "H(+)(out) + 2 nitrate(out) = H(+)(in) + 2 nitrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45910", "l": "chloroeremomycin + dTDP + H(+) => chloroorienticin B + dTDP-beta-L-vancosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114352", "l": "Sequestration of tBID by BCL-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12261", "l": "ATP + NADH => ADP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913370", "l": "Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71866", "l": "taurodeoxycholate(out) <=> taurodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68179", "l": "2-oxoglutarate + N-geranyl-L-glutamate + O2 <=> CO2 + dainate A + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0008263", "l": "pyrimidine-specific mismatch base pair DNA N-glycosylase activity", "d": ["Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129353", "l": "Tropoelastin associates with microfibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22982", "l": "a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein] => a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008832", "l": "RUNX2 binds BAX gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12926", "l": "D-erythrose 4-phosphate + L-lysyl-[protein] => H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69694", "l": "a ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine <=> a ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50289", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605797", "l": "SMPD1 hydrolyzes SPHM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032770", "l": "Translocation of YAP1 to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45177", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28477", "l": "D-glucarate(in) + H(+)(in) <=> D-glucarate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44365", "l": "2-epi-5-epi-valiolone + ATP => 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37679", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848077", "l": "PTK6 phosphorylates STAP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58697", "l": "NADPH + O2 + rifampicin => H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56395", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141341", "l": "SMOX-3 oxidises SPN to SPM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.197", "l": "\"high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865182", "l": "OTUD7A hydrolyses K11diUb (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58676", "l": "NADPH + O2 + rifamycin SV = H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34158", "l": "acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine <=> CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45494", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62032", "l": "a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O = a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204500", "l": "CyP60 chaperones Basigin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0099583", "l": "neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18455", "l": "[(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate => [(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63518", "l": "biphenyl-2,2',3,3'-tetraol + H2O + NAD(+) => biphenyl-2,2',3-triol + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18018", "l": "H(+) + indole-3-pyruvate => CO2 + indole-3-acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0016649", "l": "oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound."], "t": []}, {"i": "EC:1.5.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51176", "l": "cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9761474", "l": "AMOT-2 binds CDH11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388468", "l": "AVP(20-28) binds AVPR1A,B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62833", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71071", "l": "L-arginine(in) + L-cysteine(out) = L-arginine(out) + L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0140713", "l": "histone chaperone activity", "d": ["Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone)."], "t": []}, {"i": "REACT:R-HSA-9822185", "l": "HIRA and NPM2 assemble H3.3-containing nucleosomes on paternal DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160082", "l": "hypoxia-inducible factor-proline dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37525", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61043", "l": "(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30605", "l": "AH2 + all-trans-phytofluene => 15-cis-phytoene + A", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62871", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2 <=> H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76106", "l": "(11R)-carlactonoate + S-adenosyl-L-methionine <=> (11R)-methyl carlactonoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008972", "l": "phosphomethylpyrimidine kinase activity", "d": ["Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042561", "l": "alpha-amyrin synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = alpha-amyrin. This reaction is a cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into alpha-amyrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27990", "l": "1-deoxy-D-xylulose + ATP = 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.316", "l": "\"mitomycin 6-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63829", "l": "L-alanine + vanillin => pyruvate + vanillylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53936", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 = 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.14", "l": "\"lignin peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614591", "l": "Excess cysteine yields lanthionine and H2S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950347", "l": "IL12A:IL12B translocates from late endosome lumen to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046175", "l": "Further sulfation on galactose residues produces KSPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54702", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+) => 4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9710959", "l": "p-STAT1 dimer binds KPNA1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23205", "l": "chlorogenate + D-glucarate => 2-O-caffeoylglucarate + L-quinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57226", "l": "N(2)-(1-hydroxy-2-oxoethyl)-GTP => glyoxal + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53548", "l": "prostaglandin J2 = Delta(12)-prostaglandin J2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42948", "l": "cytidine(48) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.2", "l": "\"peptidyl-glycinamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664275", "l": "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10551", "l": "L-arginine + O2 <=> 4-guanidinobutanamide + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13756", "l": "2 L-glutamate + NAD(+) <=> 2-oxoglutarate + H(+) + L-glutamine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68232", "l": "L-cysteine(in) + Na(+)(in) = L-cysteine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33723", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine = a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52567", "l": "2-dehydro-L-erythronate <=> 3-dehydro-L-erythronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810076", "l": "DDO oxidizes D-Asp to OA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55887", "l": "[aequorin] + 3 Ca(2+) <=> [aequorin]--dioxetanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614665", "l": "SQR oxidizes sulfide to bound persulfide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49548", "l": "H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] = H(+) + L-arginyl-[protein] + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42394", "l": "D-galactono-1,5-lactone + H(+) + NADH => D-galactose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9689680", "l": "IFNG dimer binds IFNG inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25502", "l": "diphosphate + terpinolene => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805546", "l": "Keratin type I binds keratin type II (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031859", "l": "platelet activating factor receptor binding", "d": ["Binding to a platelet activating factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686430", "l": "MUS81 binds EME1, EME2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60345", "l": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60084", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) = a 4alpha-methyl-3-oxosteroid + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76156", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 19-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30780", "l": "D-gluconate + FAD + H(+) => 2-dehydro-D-gluconate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033569", "l": "lactoferrin transmembrane transporter activity", "d": ["Enables the transfer of lactoferrin from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78415", "l": "carbendazim + H2O = H(+) + methanol + N-(1H-1,3-benzodiazol-2-yl)carbamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176116", "l": "Recruitment and activation of Chk1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990915", "l": "structural constituent of ascospore wall", "d": ["The action of a molecule that contributes to the structural integrity of an ascospore wall."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033928", "l": "mannan 1,4-mannobiosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-mannosidic linkages in (1->4)-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47219", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030786", "l": "(RS)-norcoclaurine 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937419", "l": "CBR3 reduces DOX to DOXOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77191", "l": "an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19702", "l": "a flavonol 3-O-glycoside + UDP-alpha-D-xylose => a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090591", "l": "protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetyl-mannosamine(out) = protein histidine +N-acetyl- mannosamine-6-phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.3.-", "l": "\"With H(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416698", "l": "SEMA5A binds to PLXNB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74308", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + NAD(+) => 12alpha-hydroxy-3-oxochola-4-en-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444523", "l": "CXCR5 binds CXCL13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299487", "l": "Precursor proteins enter TIMM23 SORT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1006169", "l": "Factor H binds host cell surface markers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851018", "l": "BTN2A1 binds DC-SIGN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60459", "l": "ATP + UTP <=> 3',3'-cUAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990407", "l": "calcitonin gene-related peptide binding", "d": ["Binding to calcitonin gene-related peptide (CGRP)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029471", "l": "Hydrolysis of PC to PA by PLD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31274", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47725", "l": "glutathione => 5-oxo-L-proline + L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005173", "l": "stem cell factor receptor binding", "d": ["Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0061840", "l": "high-affinity ferrous iron transmembrane transporter activity", "d": ["Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611839", "l": "β3-agonists bind ADRB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11873", "l": "corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76152", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 18-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22164", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a globoside Forssman (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.88", "l": "\"globoside alpha-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193703", "l": "IKKbeta is activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74164", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14128", "l": "2 raffinose <=> 1(F)-alpha-D-galactosylraffinose + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14168", "l": "acetyl-CoA + L-aspartate <=> CoA + H(+) + N-acetyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19681", "l": "ATP + biotin + CoA = AMP + biotinyl-CoA + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.11", "l": "\"biotin--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46410", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16414", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] => L-lysyl-[glycine-cleavage complex H protein] + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062147", "l": "L-lysine 4-chlorinase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + chloride + H+ + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate."], "t": []}, {"i": "RHEA:59884", "l": "2-oxoglutarate + chloride + H(+) + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70240", "l": "a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112271", "l": "The receptor:G-protein complex dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58449", "l": "N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50512", "l": "acetyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76923", "l": "2-methylcyclopentanamine + H2O + NADP(+) = 2-methylcyclopentanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46897", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) => a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70145", "l": "28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53643", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-amorphene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653936", "l": "Formation of Ragulator complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450494", "l": "HuR binds mRNAs in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754964", "l": "ADA deamidates RBV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658435", "l": "RAS GAPs bind RAS:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53409", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 => (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56901", "l": "a globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine => a globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676596", "l": "TRAF3 binds BAFFR:BAFF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429699", "l": "CERT1-2 complex binds ceramide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18809", "l": "L-alanine + oxomalonate = aminomalonate + pyruvate", "d": [], "t": []}, {"i": "EC:2.6.1.47", "l": "\"alanine--oxomalonate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035717", "l": "chemokine (C-C motif) ligand 7 binding", "d": ["Binding to chemokine (C-C motif) ligand 7."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418662", "l": "Src activation following P2Y purinoceptor activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44540", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34447", "l": "dTDP-6-deoxy-beta-L-talose + NAD(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687107", "l": "MAPK4,6 translocate to nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64658", "l": "(E)-sinapoyl-CoA + H(+) + NADPH => (E)-sinapaldehyde + CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63391", "l": "2 A + Fe(II)-heme o + H2O <=> 2 AH2 + Fe(II)-heme a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163750", "l": "Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686469", "l": "Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69239", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate <=> 4-hydroxybutylnitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53729", "l": "H2O + N-acetyl-D-muramate 6-phosphate => N-acetyl-D-muramate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26231", "l": "geranylgeranyl diphosphate + 3 H(+) + 3 NADPH => 3 NADP(+) + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12259", "l": "L-arogenate + NAD(+) <=> CO2 + L-tyrosine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53192", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15616", "l": "NAD(+) + precorrin-2 <=> 2 H(+) + NADH + sirohydrochlorin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28794", "l": "5,6-dihydrothymine + NAD(+) <=> H(+) + NADH + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662818", "l": "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28656", "l": "glutathione S,S-dioxide + H2O => glutathione + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51372", "l": "(9Z)-hexadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z-hexadecenoyl)-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53546", "l": "7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34739", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine = H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38242", "l": "(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA <=> 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714481", "l": "RAC2 binds effectors at the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102560", "l": "5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity", "d": ["Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O = D-ribofuranose 2,5-bisphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444661", "l": "HCAR2 binds HCAR2 ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112755", "l": "SOCS3 binds IL6ST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980122", "l": "DTX binds NOTCH1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14410", "l": "cysteamine + O2 => H(+) + hypotaurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37795", "l": "2 H(+) + 2 NADPH + O2 = 2 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19515", "l": "H(+) + L-citrulline + phosphate => carbamoyl phosphate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11099", "l": "NADP(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12716", "l": "a nucleoside 5'-phosphate + ATP <=> a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47485", "l": "deoxycholate + NAD(+) => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67326", "l": "(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine => acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28734", "l": "H(+)(out) + L-leucine(in) <=> H(+)(in) + L-leucine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57843", "l": "1D-myo-inositol 1,3-bisphosphate + H2O <=> 1D-myo-inositol 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17539", "l": "(R)-carnitine + NH4(+) => (R)-carnitinamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46119", "l": "2-dehydro-3-deoxy-D-galactonate <=> D-glyceraldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43249", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69850", "l": "a 5,6-dihydrouridine in RNA + NADP(+) <=> a uridine in RNA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67888", "l": "3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine = 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26159", "l": "D-mannose + NADP(+) <=> 2-dehydro-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2301205", "l": "SETD8 monomethylates histone H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45200", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": [], "t": []}, {"i": "EC:2.1.1.258", "l": "\"5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191784", "l": "snRNA Cap hypermethylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42319", "l": "a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] <=> an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871227", "l": "RET binds GFRA4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400434", "l": "FFAR1 binds fatty acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43710", "l": "diphosphate + hexadecanoyl-AMP => ATP + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10014", "l": "6-hydroxypseudooxynicotine + H2O2 => (R)-6-hydroxynicotine + H2O + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004468", "l": "lysine N-acetyltransferase activity, acting on acetyl phosphate as donor", "d": ["Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74852", "l": "acetaldehyde + dopamine => (R)-salsolinol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167415", "l": "G-protein alpha subunit is inactivated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43235", "l": "H2O + isatin <=> H(+) + isatinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0003684", "l": "damaged DNA binding", "d": ["Binding to damaged DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611277", "l": "P2RY12 binds P2RY12 antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618405", "l": "ARL4C mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9612509", "l": "SGK phosphorylates SRF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044686", "l": "cysteate synthase activity", "d": ["Catalysis of the reaction: O-phospho-L-serine + sulfite + H+ = L-cysteate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50338", "l": "H(+) + H2O + omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + triacontanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36931", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9669893", "l": "KIT binds type I TKIs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68120", "l": "a 1,2-diacylglycerol + a fatty acyl-CoA = a triacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30048", "l": "chloroacetaldehyde + H2O + NAD(+) => chloroacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428127", "l": "SPTLC complexes transfer acyl-CoA onto serine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67199", "l": "H2O + N-acetylserotonin <=> acetate + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66771", "l": "ATP + coproporphyrin I(in) + H2O <=> ADP + coproporphyrin I(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004587", "l": "ornithine aminotransferase activity", "d": ["Catalysis of the reaction: a 2-oxocarboxylate + L-ornithine = an L-alpha-amino acid + L-glutamate 5-semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25445", "l": "(2E,6E)-farnesyl diphosphate => (1E,4E)-germacrene B + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21160", "l": "acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA", "d": [], "t": []}, {"i": "EC:2.3.3.8", "l": "\"ATP citrate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1982066", "l": "Ligand-independent phosphorylation of overexpressed FGFR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389352", "l": "Translocation of Vav1 to CD28 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9842835", "l": "KRAB-ZFP binds retroelement DNA in chromatin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11343", "l": "5-guanidino-2-oxopentanoate + H(+) <=> 4-guanidinobutanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140851", "l": "histone H3K14 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 3 at the lysine-14 residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28560", "l": "D-fructose + phosphate => D-fructose 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68818", "l": "(E)-alpha-bisabolene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52984", "l": "7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] = 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987043", "l": "IL22RA1 binds JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19530", "l": "isovitexin + UDP-alpha-D-glucose => H(+) + isovitexin 2''-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30710", "l": "putrescine + pyruvate <=> 4-aminobutanal + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39709", "l": "a long-chain fatty acyl-CoA(in) => a long-chain fatty acyl-CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50952", "l": "7-chloro-L-tryptophan + AH2 + O2 = A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997237", "l": "SH2B proteins bind JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858647", "l": "HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42533", "l": "uridine(55) in tRNA => pseudouridine(55) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70041", "l": "3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174916", "l": "Formation of N-glucuronides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51668", "l": "2 H(+) + mevastatin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pravastatin lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24080", "l": "ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)", "d": [], "t": []}, {"i": "EC:6.1.1.2", "l": "\"tryptophan--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050632", "l": "propionyl-CoA C2-trimethyltridecanoyltransferase activity", "d": ["Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53365", "l": "5,6-dihydrouridine(47) in tRNA + NAD(+) => H(+) + NADH + uridine(47) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10844", "l": "oxaloacetate + pyridoxamine = L-aspartate + pyridoxal", "d": [], "t": []}, {"i": "EC:2.6.1.31", "l": "\"pyridoxamine--oxaloacetate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16588", "l": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77068", "l": "Activation of GT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47324", "l": "(S)-3-amino-3-phenylpropanoate + pyruvate = 3-oxo-3-phenylpropanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74733", "l": "Insulin receptor de-phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77293", "l": "1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033759", "l": "flavone synthase activity", "d": ["Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36250", "l": "(E)-anol + S-adenosyl-L-methionine <=> (E)-anethole + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63078", "l": "2-acetylphloroglucinol + 3 CO2 + 4 CoA => acetyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37183", "l": "(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696960", "l": "USP49 deubiquitinates H2B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71210", "l": "iodide(out) + 2 Na(+)(out) <=> iodide(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69068", "l": "RFC dissociates after sliding clamp formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40354", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP <=> 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667456", "l": "AVPR1A,B bind desmopressin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22010", "l": "CoA + O-succinyl-L-homoserine => L-homoserine + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112434", "l": "Formation of DSIF complex  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48642", "l": "11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097016", "l": "L27 domain binding", "d": ["Binding to a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404200", "l": "IGF1,2 binds IGF1R (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17604", "l": "ATP + D-ribulose <=> ADP + D-ribulose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0030021", "l": "extracellular matrix structural constituent conferring compression resistance", "d": ["A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76763", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] = 1,4-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111970", "l": "PKC phosphorylates GRK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66029", "l": "AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine => (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47099", "l": "(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate <=> (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322431", "l": "XIAP binds TLE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0031072", "l": "heat shock protein binding", "d": ["Binding to a heat shock protein, a protein synthesized or activated in response to heat shock."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11651", "l": "(-)-menthol + H(+) + NADPH + O2 <=> 1,4-menthane-3,8-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209960", "l": "Diiodinated tyrosine can be deiodinated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73926", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine <=> griseophenone D + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41058", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952996", "l": "E2F7 forms homodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47257", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950057", "l": "IL12RB1 binds TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.616479785166973", "identifiers": [{"i": "GO:0016713", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19834", "l": "(6R)-10-formyltetrahydrofolate + H2O => (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507868", "l": "Aquaporins passively transport water into cells (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004380", "l": "glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72468", "l": "2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA => 6 CO2 + 8 CoA + H2O + o-orsellinate depside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30682", "l": "D-cellobiose + H2O <=> beta-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102281", "l": "formylaminopyrimidine deformylase activity", "d": ["Catalysis of the reaction: formylaminopyrimidine + H2O = 4-amino-5-ammoniomethyl-2-methylpyrimidine + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72606", "l": "(E)-sinapate + ATP + H(+) <=> (E)-sinapoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34647", "l": "S-adenosyl-L-methionine + squalene = 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40154", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32182", "l": "(S)-2,3-dihydrodipicolinate + NAD(+) <=> dipicolinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928615", "l": "EFNBs bind SFKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74489", "l": "(-)-4'-methoxycyclopeptine + 2 AMP + 2 diphosphate + 2 H(+) + S-adenosyl-L-homocysteine => anthranilate + 2 ATP + O-methyl-L-tyrosine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2984226", "l": "PLK1 phosphorylates NEK9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426032", "l": "DAG is metabolized by DAGL to 2-AG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11581", "l": "a CDP-1,2-diacyl-sn-glycerol + myo-inositol => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876210", "l": "InlB promotes MET dimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77472", "l": "hydrogen cyanide + pentan-2-one => (2S)-2-hydroxy-2-methylpentanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183067", "l": "Localization of CBL:GRB2 to the membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69481", "l": "an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72946", "l": "2 Na(+)(out) + pyruvate(out) <=> 2 Na(+)(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44990", "l": "CoA + O-isobutanoyl-(R)-carnitine => (R)-carnitine + 2-methylpropanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40328", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76541", "l": "an N-acyl-sphinga-4,8-dienine + CoA + H(+) => a fatty acyl-CoA + sphinga-(4E,8E)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857345", "l": "Activated CEBPB binds CDKN2B promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48166", "l": "H(+) + red chlorophyll catabolite => epoxypheophorbide a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42707", "l": "hercynine + L-cysteine + O2 <=> H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75244", "l": "FASL binds FAS Receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34939", "l": "H2O + menaquinone-8 + selenite = menaquinol-8 + selenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378975", "l": "Follitropin is a heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14080", "l": "3-oxopropanoate + L-alanine <=> beta-alanine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004331", "l": "fructose-2,6-bisphosphate 2-phosphatase activity", "d": ["Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350598", "l": "Arginine<=>Agmatine+CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.39", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9660192", "l": "VDR agonists bind VDR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23193", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72509", "l": "2-oxoglutarate(out) + prostaglandin F2alpha(in) => 2-oxoglutarate(in) + prostaglandin F2alpha(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683478", "l": "CQ, HCQ diffuses from cytosol to endocytic vesicle lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162099", "l": "abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57473", "l": "(E)-4-coumarate + UDP-alpha-D-glucose => 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691154", "l": "HFE binds TFRC dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50901", "l": "10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O => (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47742", "l": "CO2 + demethylphylloquinone + diphosphate => 1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26362", "l": "L-tyrosine + NADPH + S-adenosyl-L-methionine => 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70543", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047818", "l": "D-fuconate dehydratase activity", "d": ["Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34951", "l": "3-hydroxypropanoate(out) = 3-hydroxypropanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40843", "l": "FAD + H(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203774", "l": "Interaction of Csk with PAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73614", "l": "CTP(out) + dCDP(in) <=> CTP(in) + dCDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64318", "l": "2 (+)-geodin + 2 H2O => 2 dihydrogeodin + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015625", "l": "ABC-type ferric hydroxamate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24142", "l": "2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32610", "l": "(6E)-8-hydroxygeraniol + NADP(+) <=> (6E)-8-hydroxygeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693478", "l": "HTR1A binds HTR1A agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.244991688848543", "identifiers": [{"i": "GO:0032452", "l": "histone demethylase activity", "d": ["Catalysis of the removal of a methyl group from a histone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65028", "l": "(+)-pinoresinol + H2O + 2 oxidized [azurin] = (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}, {"i": "EC:1.17.9.2", "l": "\"(+)-pinoresinol hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60900", "l": "a cytidine in RNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48772", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a = 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42021", "l": "11-dehydrocorticosterone + NAD(+) => H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404142", "l": "atROL binds RBP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047309", "l": "dihydroxyphenylalanine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-dopa = 3,4-dihydroxyphenylpyruvate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665727", "l": "FMNL2 binds CDC42:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16249", "l": "alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate", "d": [], "t": []}, {"i": "EC:5.1.3.15", "l": "\"glucose-6-phosphate 1-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29596", "l": "CoA + NADP(+) + sulfoacetaldehyde => H(+) + NADPH + sulfoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13039", "l": "ITP + NH4(+) => ATP + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670156", "l": "PtdIns(4,5)P2 binds WASP, N-WASP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18223", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate => 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727188", "l": "ATP4A:ATP4B binds PPIs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33785", "l": "1,6-kestotetraose + beta-D-glucose => 1(F)-beta-D-fructosylsucrose + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995334", "l": "COX15 transforms heme O to heme A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52071", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22793", "l": "isonocardicin A => nocardicin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41944", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP", "d": [], "t": []}, {"i": "EC:2.7.2.17", "l": "\"[amino-group carrier protein]-L-2-aminoadipate 6-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045504", "l": "dynein heavy chain binding", "d": ["Binding to a heavy chain of the dynein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67337", "l": "kaempferol 3-O-beta-D-glucoside + malonyl-CoA => CoA + kaempferol 3-O-(6-O-malonyl-beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52091", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA <=> 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50832", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48276", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12118", "l": "AH2 => A + H2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32566", "l": "(2E)-geranyl diphosphate <=> alpha-terpinene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700662", "l": "Liganded-ALK dimer binds type I ALK-binding TKIs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36428", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848395", "l": "IL18:IL18R1 binds IL18RAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61947", "l": "24-methylenecholesterol + UDP-alpha-D-glucose <=> 24-methylene cholesteryl beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17467", "l": "L-rhamnopyranose + quercetin => H2O + quercitrin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610735", "l": "NUMB binds ITCH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008783", "l": "agmatinase activity", "d": ["Catalysis of the reaction: agmatine + H2O = putrescine + urea."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42800", "l": "15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) = all-trans-4,4'-diaponeurosporene + 3 FADH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75677", "l": "(12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3159259", "l": "MMAA:MUT binds AdoCbl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35227", "l": "H(+)(out) + rifampicin(in) = H(+)(in) + rifampicin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59787", "l": "H2O + NADP(+) + pseudopaline <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.45", "l": "\"atrolysin F\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65412", "l": "dAMP(in) + NAD(+)(out) = dAMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70688", "l": "4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) => 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-708349", "l": "Activated NOD2 oligomerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.9", "l": "\"glucose-6-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30542", "l": "(R)-carnitinyl-CoA <=> (S)-carnitinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.2", "l": "\"ABC-type Cd(2+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29417", "l": "(S)-lactate(out) + H(+)(out) => (S)-lactate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55734", "l": "19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15858", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) => 17alpha-hydroxyprogesterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28449", "l": "1-deoxy-D-xylulose(in) <=> 1-deoxy-D-xylulose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879909", "l": "Activation of STAT5a/b by JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799466", "l": "TP53I3 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25930", "l": "3-methylquinolin-2(1H)-one + AH2 => 3-methylquinoline + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25819", "l": "H2O + norspermine + O2 <=> 3-aminopropanal + H2O2 + norspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56139", "l": "2 a phenolic donor + H2O2 <=> 2 a phenolic radical donor + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018758", "l": "RHOH binds effectors at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48863", "l": "18-HEPE + O2 <=> (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804425", "l": "TP53 binds POU4F2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9705926", "l": "AR binds AR agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56461", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35771", "l": "5-deoxy-5-amino-3-dehydroshikimate = 3-amino-5-hydroxybenzoate + H(+) + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.144", "l": "\"3-amino-5-hydroxybenzoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52455", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate <=> 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28220", "l": "H2O + hypochlorous acid => chloride + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71787", "l": "2-oxoadipate + O2 = (R)-2-hydroxyglutarate + CO2", "d": [], "t": []}, {"i": "EC:1.13.11.93", "l": "\"2-oxoadipate dioxygenase/decarboxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10022", "l": "(S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH => H2O + L-saccharopine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15866", "l": "AH2 + O2 + tryptamine => 4-hydroxytryptamine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.5", "l": "\"sphingolipid C4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24842", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21708", "l": "H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine", "d": [], "t": []}, {"i": "EC:3.13.2.1", "l": "\"adenosylhomocysteinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.24", "l": "\"succinate-semialdehyde dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398188", "l": "PLC beta is activated by G alpha (q) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64423", "l": "H(+)(out) + L-alanyl-L-proline(out) <=> H(+)(in) + L-alanyl-L-proline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.78", "l": "\"phosphopolyprenol glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35047", "l": "adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin", "d": [], "t": []}, {"i": "EC:2.10.1.1", "l": "\"molybdopterin molybdotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103063", "l": "trans-keto-C61-meroacyl-AMP ligase activity", "d": ["Catalysis of the reaction: ATP(4-) + H2O + a trans-keto-C61-meroacyl-[acp] = diphosphoric acid + a trans-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14377", "l": "(3R)-3-hydroxy-L-aspartate = glycine + glyoxylate", "d": [], "t": []}, {"i": "EC:4.1.3.14", "l": "\"L-erythro-3-hydroxyaspartate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34283", "l": "2 L-tyrosine + O2 = 2 L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50705", "l": "1-propanol + NAD(+) => H(+) + NADH + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.65", "l": "\"peptidase 1 (mite)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008513", "l": "secondary active organic cation transmembrane transporter activity", "d": ["Enables the transfer of organic cations from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction."], "t": []}, {"i": "REACT:R-HSA-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102062", "l": "alpha-santalene synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate = (+)-alpha-santalene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45431", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25949", "l": "a 1,2-diacyl-sn-glycerol + CTP => a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39959", "l": "1-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75390", "l": "H2O + queuosine 5'-phosphate <=> D-ribose 5-phosphate + queuine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694601", "l": "nsp3-4 cleaves itself (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18557", "l": "1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA = 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.105", "l": "\"alkylglycerophosphate 2-O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72580", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O => (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16656", "l": "D-gluconate + NADP(+) <=> 2-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29451", "l": "H2O + phosphonate = H2 + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29262", "l": "(2R,3R)-tartrate(out) + succinate(in) <=> (2R,3R)-tartrate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.61", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36979", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031489", "l": "myosin V binding", "d": ["Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47525", "l": "cholate + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.53", "l": "\"calpain-2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52590", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH => choloyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58653", "l": "rifamycin SV ortho-naphthoquinone carboxamide => rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69593", "l": "CMP + inosine => cytidine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381290", "l": "PPARG:RXRA heterodimer binds to PPARG corepressors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047840", "l": "dCTP diphosphatase activity", "d": ["Catalysis of the reaction: dCTP + H2O = dCMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8979071", "l": "KDM6B binds iron (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36481", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74847", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + ATP = 3-diphospho-1D-myo-inositol 1,2,4,5-tetrakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950389", "l": "Expression of Stress-70 protein, mitochondrial (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78632", "l": "hexacosanoyl-CoA + O2 => (2E)-hexacosenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46239", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41511", "l": "L-ornithine + NADPH + O2 <=> H2O + N(5)-hydroxy-L-ornithine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52648", "l": "H2O + L-arabino-1,4-lactone 5-phosphate = 5-phospho-L-arabinonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39055", "l": "22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42454", "l": "H2O + kynurenate => 4-(2-aminophenyl)-2,4-dioxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9845032", "l": "CLIP1-LTK fusion binds PI3K to activate AKT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0003867", "l": "4-aminobutyrate transaminase activity", "d": ["Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12201", "l": "2'-deoxymugineate + 2-oxoglutarate + O2 => CO2 + mugineate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67574", "l": "adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + alpha-muricholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60731", "l": "citral + H2O + NADP(+) <=> 3,7-dimethylocta-2,6-dienoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052581", "l": "(-)-isopiperitenone reductase activity", "d": ["Catalysis of the reaction: (6R)-isoperitenone + H+ + NADPH = (2R,5R)-isopulegone + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008733", "l": "L-arabinose isomerase activity", "d": ["Catalysis of the reaction: L-arabinose = L-ribulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034805", "l": "benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene-trans-11,12-dihydrodiol = 11,12-dihydroxybenzo(a)pyrene + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939201", "l": "ESR dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34926", "l": "nitrate(in) <=> nitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247497", "l": "ERBB3 binds neuregulins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58252", "l": "H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] = ADP-D-ribose + L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.92", "l": "\"fatty acid alpha-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21539", "l": "(3S)-hydroxy-3-methylglutaryl-CoA <=> 3-methyl-(2E)-glutaconyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14212", "l": "alpha-D-galactose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27379", "l": "(2R)-2-phosphoglycerate + ADP + H(+) => (R)-glycerate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18113", "l": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641229", "l": "TLE oligomerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76135", "l": "a dicarboxylate(in) + urate(out) = a dicarboxylate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46746", "l": "ADP + carboxyphosphate => ATP + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37344", "l": "adenosine 2'-phosphate + H2O => adenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940100", "l": "CDK1 phosphorylates VCPIP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8934465", "l": "SHC1 binds PTPN12 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66445", "l": "hexan-3-one + NADP(+) => (E)-4-hexen-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42744", "l": "guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.174", "l": "\"23S rRNA (guanine(1835)-N(2))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193519", "l": "DHCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38932", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30126", "l": "H2O + tetradecanoyl-[ACP] <=> H(+) + holo-[ACP] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57778", "l": "4-chloro-3-methylcatechol + NAD(+) + nitrite => 2-chloro-6-nitrotoluene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15365", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37650", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662647", "l": "MT4 binds copper (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786650", "l": "DDHD1,2 hydrolyse PA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31242", "l": "4 H(+) + uroporphyrinogen I <=> 4 CO2 + coproporphyrinogen I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74059", "l": "PDE6 hydrolyses cGMP to GMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45233", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62112", "l": "(3S)-3-hydroxy-D-aspartate = H2O + iminosuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15078", "l": "H(+) + N-[(R)-pantothenoyl]-L-cysteine => (R)-pantetheine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854466", "l": "VLDLR binds RELN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848774", "l": "PTK6 binds DOK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964759", "l": "Alternative endo-mannosidase I route (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69048", "l": "H2O + hexano-6-lactone = 6-hydroxyhexanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69318", "l": "allyl thiocyanate + sulfate => (Z)-N-(sulfonatooxy)prop-2-enimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34795", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.55", "l": "\"phosphoribosyl 1,2-cyclic phosphate phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653936", "l": "Formation of Ragulator complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23390", "l": "7''-O-phosphohygromycin B + ADP + H(+) => ATP + hygromycin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46021", "l": "[pyruvate, water dikinase] + ADP => [pyruvate, water dikinase]-phosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30032", "l": "(S)-muconolactone => cis,cis-muconate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18335", "l": "ADP + H(+) + oleandomycin 2'-O-phosphate => ATP + oleandomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426489", "l": "RISC binds inexactly matching target RNAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9839381", "l": "FGF2:TGFBR3 binding to GIPC1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74898", "l": "nitric oxide(out) <=> nitric oxide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684108", "l": "BRCA1 binds phosphorylated RBBP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56828", "l": "2,3,6-trichlorohydroquinone + chloride + glutathione disulfide = 2,3,5,6-tetrachlorohydroquinone + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019010", "l": "farnesoic acid O-methyltransferase activity", "d": ["Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56490", "l": "H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolate + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58807", "l": "5'-pApG-3' + H2O <=> 5'-ApG-3' + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30672", "l": "H2O + N,N'-diacetylchitobiose => 2 N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16765", "l": "D-mannitol + NADP(+) = D-fructose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.138", "l": "\"mannitol 2-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983147", "l": "Release of E3 from polyubiquitinated substrate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25914", "l": "5-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-5-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38278", "l": "(3R)-citramalyl-CoA <=> acetyl-CoA + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22251", "l": "7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) <=> 7,8-dihydroxykynurenate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72272", "l": "formate(out) + oxalate(in) => formate(in) + oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102216", "l": "maltodextrin water dikinase", "d": ["Catalysis of the reaction: ATP + H2O + a maltodextrin = AMP + hydrogenphosphate + a 6-phosphogluco-maltodextrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213200", "l": "Release of endostatin-like peptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37897", "l": "26-deglucoprotodioscin + D-glucose => H2O + protodioscin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54096", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75826", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] <=> 5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63568", "l": "beta-casomorphin-7 + H2O = beta-casomorphin-6 + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56627", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O <=> 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088162", "l": "FOXM1 binds CDC25A promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689630", "l": "BAP1 binds BAP1-interacting complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32441", "l": "albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => (+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28986", "l": "nitrite(in) <=> nitrite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222704", "l": "KatG reduces H2O2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010113", "l": "ADAM10:Zn2+ binds TSPANs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65903", "l": "3-hydroxy-L-kynurenine + glyoxylate <=> glycine + H2O + xanthurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23704", "l": "GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate", "d": [], "t": []}, {"i": "EC:3.5.4.25", "l": "\"GTP cyclohydrolase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31514", "l": "chenodeoxycholoyl-CoA + H2O <=> chenodeoxycholate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0042010", "l": "interleukin-15 receptor activity", "d": ["Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450348", "l": "Activated human JNKs migrate to nucleoplasm (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23762", "l": "reduced coenzyme F420-(gamma-L-Glu)(n) => H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14739", "l": "3',5'-cyclic CMP + diphosphate => CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47471", "l": "(2E,4E)-tetradecadienoyl-CoA <=> (3E,5Z)-tetradecadienoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24733", "l": "anthranilate + H(+) <=> aniline + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987096", "l": "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008996", "l": "ribonuclease G activity", "d": ["Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29656", "l": "L-cysteine(in) => L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41128", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19117", "l": "dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}, {"i": "EC:1.14.17.1", "l": "\"dopamine beta-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47958", "l": "H(+) + maleate + pyruvate => 3-maleylpyruvate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807826", "l": "LDHAL6B reduces PYR to LACT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64524", "l": "(2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA = 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015110", "l": "cyanate transmembrane transporter activity", "d": ["Enables the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13520", "l": "ATP + dTMP <=> ADP + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15352", "l": "L-glutamate + N(2)-acetyl-L-ornithine <=> L-ornithine + N-acetyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211650", "l": "Autophosphorylation of PAK-2p34 in the activation loop (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43691", "l": "N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate <=> L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44285", "l": "2 H(+) + 2 malonyl-CoA + octanoyl-CoA => 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72389", "l": "2 hydrogencarbonate(in) + sulfate(out) => 2 hydrogencarbonate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389756", "l": "AKT interacts and phosphorylates Cot (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58607", "l": "FAD + 2 H(+) + NADH + O2 <=> FADH2-C4alpha-hydroperoxide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73889", "l": "chloride(in) + Na(+)(in) => chloride(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043767", "l": "pyrrolysyl-tRNA synthetase activity", "d": ["Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782419", "l": "TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56113", "l": "2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 => 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55442", "l": "H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798139", "l": "TP53 stimulates CASP10 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953398", "l": "PIR oxygenates quercetin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604732", "l": "Autocatalytic activation of proMMP13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15222", "l": "a CDP-1,2-diacyl-sn-glycerol + H2O => a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74858", "l": "dopamine + pyruvate <=> (R)-salsolinol-1-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56948", "l": "pyruvate + UTP = H(+) + phosphoenolpyruvate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25671", "l": "sucrose + UDP-alpha-D-galactose => H(+) + loliose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37252", "l": "cysteamine S-phosphate + H2O => cysteamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0016731", "l": "oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP."], "t": []}, {"i": "EC:1.18.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74998", "l": "epierythrostominol(in) <=> epierythrostominol(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981355", "l": "RASA1 binds RAS:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395764", "l": "atREs binds to nascent CM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13093", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548830", "l": "ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69885", "l": "L-ascorbate(in) + 2 Na(+)(in) => L-ascorbate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165195", "l": "GTP loading by Rheb (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465924", "l": "OPN1LW binds 11cRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43048", "l": "keto-D-tagatose = keto-D-sorbose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76734", "l": "a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione <=> a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938440", "l": "miR-17 binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417842", "l": "P2Y10 receptor can bind to LPA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9839378", "l": "TGFBR3 binding to ARRB1/2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166817", "l": "Cleavage of C3 by C3 convertases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034257", "l": "nicotinamide riboside transmembrane transporter activity", "d": ["Enables the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445705", "l": "Release Of ADP From Myosin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49086", "l": "(-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65560", "l": "2-oxoglutarate + L-kynurenine = H2O + kynurenate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034850", "l": "isooctane monooxygenase activity", "d": ["Catalysis of the reaction: isooctane + 1/2 O2 = 2,4,4-trimethyl-1-pentanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23697", "l": "myo-inositol + O2 => D-glucuronate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0003906", "l": "DNA-(apurinic or apyrimidinic site) endonuclease activity", "d": ["Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41014", "l": "(+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) <=> (+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990882", "l": "CDK1 phosphorylates NUP98 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299338", "l": "Activation of TRESK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30766", "l": "H2O + L-valine + NAD(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10584", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.170", "l": "\"6'-deoxychalcone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60025", "l": "(R,R)-chrysanthemyl diphosphate + H2O => (R,R)-chrysanthemol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68886", "l": "3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+) => 3-hydroxybenzoate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228407", "l": "tetX HC:LC binds target cell-surface gangliosides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299318", "l": "Activation of TASK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227778", "l": "MEKK1 binds TRAF6  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44007", "l": "3-methyl fatty acid + ATP + CoA <=> a 3-methyl fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44274", "l": "4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53122", "l": "5alpha-dihydrotestosterone sulfate + H(+) + NADPH => (3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685195", "l": "SARS-CoV-1 9b recruits ITCH to MAVS  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64699", "l": "benzyl alcohol + NAD(+) <=> benzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880053", "l": "2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30854", "l": "beta-D-fructose 1-phosphate <=> D-glyceraldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31267", "l": "6-hydroxyhexanoate + NADP(+) = 6-oxohexanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67229", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA => (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55893", "l": "a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 => a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64293", "l": "3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH => (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140856", "l": "histone H2AK13 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-13 residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77260", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61033", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine => 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32650", "l": "erythromycin C + S-adenosyl-L-methionine <=> erythromycin A + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13808", "l": "A + a 3-oxo-5alpha-steroid <=> a 3-oxo-Delta(4)-steroid + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68658", "l": "7beta-hydroxycholesterol + NADP(+) => 7-oxocholesterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66593", "l": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA => a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9645598", "l": "RRAGC,D hydrolyzes GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047493", "l": "ceramide cholinephosphotransferase activity", "d": ["Catalysis of the reaction: CDP-choline + ceramide = CMP + H+ + sphingomyelin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610720", "l": "PKA phosphorylates GLI3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047014", "l": "glycerol-3-phosphate 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + NADP+ = D-glyceraldehyde 3-phosphate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71348", "l": "chloride(out) + L-lysine(out) + 2 Na(+)(out) => chloride(in) + L-lysine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46800", "l": "H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:7.2.1.2", "l": "\"ferredoxin--NAD(+) oxidoreductase (Na(+)-transporting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38780", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14256", "l": "guanosine 3',5'-bis(diphosphate) + H2O <=> diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004846", "l": "urate oxidase activity", "d": ["Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57044", "l": "D-apionate + NAD(+) = 3-oxoisoapionate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.421", "l": "\"D-apionate oxidoisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034556", "l": "nitrobenzoate nitroreductase activity", "d": ["Catalysis of the reaction: o-nitrobenzoate + NADPH + H+ = o-hydroxylaminobenzoate + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67082", "l": "a very long-chain fatty acid(out) + ADP + H(+) + phosphate => a very long-chain fatty acid(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833446", "l": "NS1 (1C) binds to CREBBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353300", "l": "MGMT mediated DNA Damage Reversal (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74546", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (E,E,E)-alpha-springene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65266", "l": "AH2 + chrodrimanin C => 3-hydroxypentacecilide A + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68202", "l": "1,2-dihexanoyl-3-hexadecanoylglycerol + CoA => 1,2-dihexanoylglycerol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804596", "l": "APAF1:CYCS binds APIP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43377", "l": "5'-deoxyinosine + phosphate => 5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008096", "l": "juvenile hormone epoxide hydrolase activity", "d": ["Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102085", "l": "N-(4-aminobenzoyl)-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + L-glutamate + ATP = H+ + p-aminobenzoyl glutamate + AMP + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141439", "l": "Release of activated MAD2 from kinetochores (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70994", "l": "SDH complex dehydrogenates succinate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77050", "l": "4-phenylbutan-2-amine + H2O + NAD(+) <=> 4-phenylbutan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74241", "l": "alpha-D-glucose 1-phosphate + D-galactose => phosphate + solabiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47368", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose = a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.345", "l": "\"phosphatidyl-myo-inositol alpha-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22494", "l": "formamide + L-glutamate => H2O + N-formimidoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031510", "l": "Expression of APOC1 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14790", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871265", "l": "YAP1 binds TEAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18828", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose <=> [(1->6)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050326", "l": "taxifolin 8-monooxygenase activity", "d": ["Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25368", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NADP(+) => H(+) + momilactone A + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226012", "l": "Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1433415", "l": "Activation of RAC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33989", "l": "diphosphate + neoabietadiene => (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33256", "l": "2-demethylmenaquinol-7 + S-adenosyl-L-methionine => H(+) + menaquinol-7 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433725", "l": "Interaction of Afadin with F-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209141", "l": "ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75454", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953111", "l": "E2F6 binds TFDP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46865", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid A (E. coli) => a 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13996", "l": "(S)-3-amino-2-methylpropanoate + 2-oxoglutarate <=> 2-methyl-3-oxopropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047866", "l": "dimethylglycine oxidase activity", "d": ["Catalysis of the reaction: N,N-dimethylglycine + H2O + O2 = formaldehyde + H2O2 + sarcosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45981", "l": "3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004941", "l": "beta2-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033419", "l": "CUA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052762", "l": "gellan lyase activity", "d": ["Catalysis of the reaction: gellan = n beta-D-4-deoxy-delta4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp. This reaction is the eliminative cleavage of beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyluronate bonds of gellan backbone, releasing tetrasaccharides containing a 4-deoxy-4,5-unsaturated D-glucopyranosyluronic acid at the non-reducing end; in the product, the abbreviations are D-glucose (Glc), D-glucuronic acid (GlcA), and L-rhamnose (Rha)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61914", "l": "ADP + H(+) + phosphate + voriconazole(out) => ATP + H2O + voriconazole(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18816", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate <=> (3E,5R)-5-carboxy-2-oxohept-3-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985943", "l": "p-Y701-STAT1 dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76812", "l": "(S)-methioninol + H2O + NAD(+) => 1-hydroxy-4-(methythio)butan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.26", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57079", "l": "3-oxoisoapionate 4-phosphate + H2O <=> (2R)-3-phosphoglycerate + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603801", "l": "PEX19 binds PEX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23302", "l": "(2Z,6E)-farnesyl diphosphate + diphosphate => (2E)-geranyl diphosphate + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.-.-", "l": "\"Acting on peptide bonds (peptidases)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69127", "l": "Formation of the Flap Intermediate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004533", "l": "exoribonuclease H activity", "d": ["Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9855252", "l": "SDHA:SDHB binds to SDHC:SDHD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39872", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 3-acyl-sn-glycerol => a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11724", "l": "[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite = 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol", "d": [], "t": []}, {"i": "EC:1.8.4.8", "l": "\"phosphoadenylyl-sulfate reductase (thioredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067646", "l": "JAK1,JAK2,(TYK2) bind IL6ST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689000", "l": "AADAC deacetylates PHEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18554", "l": "(2R,3S)-tartrate + NAD(+) => dihydroxyfumarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840401", "l": "DELE1(143-515) is released into the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3785768", "l": "MRN complex binds DNA double strand breaks (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55310", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36862", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694549", "l": "RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635854", "l": "GLI2,3 are degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035410", "l": "dihydrotestosterone 17-beta-dehydrogenase activity", "d": ["Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0008800", "l": "beta-lactamase activity", "d": ["Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102160", "l": "cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-glucuronate = H+ + cyanidin 3-O-beta-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033997", "l": "inulin fructotransferase (DFA-I-forming) activity", "d": ["Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose-beta-D-fructofuranose 1,2':1,2'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809254", "l": "MTMR8 binds MTMR9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.18", "l": "\"methionyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686061", "l": "Nucleoprotein is ADP-ribosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37664", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24340", "l": "(R,R)-butane-2,3-diol + NAD(+) = (R)-acetoin + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.4", "l": "\"(R,R)-butanediol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53334", "l": "2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9854368", "l": "ROS,RNS oxidize ACO2:4Fe-4S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18145", "l": "ATP + beta-D-fructose = ADP + beta-D-fructose 1-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.3", "l": "\"ketohexokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72360", "l": "glutarate(in) + succinate(out) => glutarate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14622", "l": "(S)-2,3-epoxysqualene => lanosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20589", "l": "glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0033840", "l": "NDP-glucose-starch glucosyltransferase activity", "d": ["Catalysis of the reaction: NDP-glucose + (1,4-alpha-D-glucosyl)n = NDP + (1,4-alpha-D-glucosyl)n+1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64738", "l": "(E)-4-hydroxynon-2-enal + H(+) + NADPH => 4-hydroxynonanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51583", "l": "a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) <=> a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688294", "l": "SIRT5 deacetylates Cytochrome C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34386", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35351", "l": "NADP(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354060", "l": "Translocation of RIAM to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814094", "l": "ARL1:GTP binds ARFIP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0008093", "l": "cytoskeletal anchor activity", "d": ["The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805981", "l": "HMGB1 release from cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798282", "l": "TP53 and E2F4 bind the CDC25C gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30629", "l": "(2S)-2-acetolactate + H(+) + NADH => (2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622310", "l": "Activated NOD1 oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668335", "l": "CHMP7 binds LEMD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18019", "l": "CO2 + indole-3-acetaldehyde => H(+) + indole-3-pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798374", "l": "DYRK2 phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39035", "l": "an omega-hydroxy fatty acid + NAD(+) = an omega-oxo fatty acid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71295", "l": "chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out) = chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35115", "l": "4-coumaroyl-CoA + H(+) + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24567", "l": "a 3-oxo acid + succinyl-CoA <=> a 3-oxoacyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29921", "l": "ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46165", "l": "a quinone + H(+) + NADPH => a quinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38699", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607023", "l": "factor IXa associates with cell membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362386", "l": "Glycosylation of Hh (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60710", "l": "(1R,3R)-chrysanthemate + 2 H(+) + NADH => (1R,3R)-chrysanthemal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.350", "l": "\"ureidoglycolate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40276", "l": "hexadecanedioyl-CoA + O2 => (2E)-hexadecenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31212", "l": "ATP + H2O + L-selenomethionine => diphosphate + L-adenosylselenomethionine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3245898", "l": "TCN1 binds correnoids in the circulation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13490", "l": "(S)-canadine + H(+) + 2 O2 => berberine + 2 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390909", "l": "HRH2 binds hist (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20260", "l": "3-methyloxindole + NADP(+) <=> 3-methyleneoxindole + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77023", "l": "D-glutamate + H2O + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48591", "l": "2 H2O + 2 leukotriene A4 + O2 <=> 2 lipoxin B4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23979", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + ATP <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047249", "l": "sarsapogenin 3-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: (25S)-5beta-spirostan-3beta-ol + UDP-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61709", "l": "holo-[peptidyl-carrier protein] + L-seryl-5'-AMP => AMP + L-seryl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.210", "l": "\"4-methyl-5-nitrocatechol 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61536", "l": "ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218821", "l": "PDK1 phosphorylates PKC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65967", "l": "ATP + H2O + taurocholate(out) <=> ADP + H(+) + phosphate + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802915", "l": "Moderate kinase activity BRAF mutants bind RAS:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390595", "l": "Calcium Binds Troponin-C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46820", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16492", "l": "(R)-prunasin + H2O <=> D-glucose + mandelonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203979", "l": "Coat Assembly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29567", "l": "2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029272", "l": "Release of PLCG from FCGR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.25", "l": "\"shikimate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2314678", "l": "ASA- acetylates PTGS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2464822", "l": "RDH12 reduces atRAL to atROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977605", "l": "Factor H displaces Bb (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190258", "l": "FGFR2c binds to FGF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59670", "l": "D-cellohexaono-1,5-lactone + H2O2 => D-cellohexaose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5631941", "l": "SESN1,2,3 bind AMPK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73596", "l": "dCMP + H2O => dUMP + NH4+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23192", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.19", "l": "\"lycopene beta-cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218821", "l": "PDK1 phosphorylates PKC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76651", "l": "3-methylbutanal + H2O + NADP(+) = 3-methylbutanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63601", "l": "H2O + neocasomorphin => L-isoleucine + neocasomorphin-(1-5)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0000295", "l": "adenine nucleotide transmembrane transporter activity", "d": ["Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29045", "l": "(6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012036", "l": "ME1 tetramer decarboxylates MAL to PYR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55813", "l": "a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11939", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + trans-resveratrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696266", "l": "RND2 binds effectors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5220959", "l": "TDG excises 5-formylcytosine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733973", "l": "Bile salts bind FABP6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033829", "l": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0141058", "l": "histone H4 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62010", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70861", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(in) => L-asparagine(in) + L-glutamine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875623", "l": "SLC25A18,22 import L-Glu, H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22974", "l": "butanoyl-CoA + H(+) + NADPH => butanal + CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47253", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806957", "l": "MET receptor dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61466", "l": "a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5226979", "l": "ADD1:ADD2 binds DMTN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061849", "l": "telomeric G-quadruplex DNA binding", "d": ["Binding to telomeric G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures in telomeres."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39773", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55639", "l": "ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O <=> AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45331", "l": "7,8-dihydroneopterin <=> 7,8-dihydromonapterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645428", "l": "ALPK1 binds ADP-heptose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59818", "l": "a sterol ester + CoA => a long-chain fatty acyl-CoA + a sterol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709406", "l": "CO binds to Cytochrome c oxidase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45100", "l": "6-demethylmitomycin B + S-adenosyl-L-methionine = mitomycin B + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033515", "l": "TYSND1 cleaves ACOX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60379", "l": "D-glucose(out) <=> D-glucose(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22621", "l": "H(+) + L-tryptophan + O2 => 3-indoleglycolaldehyde + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67104", "l": "2-oxoglutarate + fumigatonoid C + O2 = CO2 + H2O + novofumigatonin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205286", "l": "GRB2:SOS interacts with p-KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6799466", "l": "TP53I3 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.13", "l": "\"IgA-specific metalloendopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73718", "l": "UBF-1 Binds rDNA Promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322140", "l": "Defective MTR does not transfer CH3 group from MeCbl to HCYS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79002", "l": "3-aminoavenalumate + ATP + H(+) + nitrite <=> 3-diazoavenalumate + AMP + diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705584", "l": "HMGCR dimer binds statins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34531", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.209", "l": "\"dTDP-4-amino-4,6-dideoxy-D-glucose acyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13552", "l": "beta-L-fucose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.3.12", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48348", "l": "a uridine in RNA = a pseudouridine in RNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19560", "l": "AH2 + O2 + pregna-4,9(11)-diene-3,20-dione <=> 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106343", "l": "glutarate dioxygenase activity", "d": ["Catalysis of the reaction glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18078", "l": "L-arginyl-[dinitrogen reductase] + NAD(+) => H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451470", "l": "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20210", "l": "ATP + xylitol => ADP + H(+) + xylitol 5-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21855", "l": "(R)-10-hydroxyoctadecanoate <=> (9Z)-octadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59255", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate <=> (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78956", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57599", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9853499", "l": "DLD dimer dehydrogenates dihydrolipoyl (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35464", "l": "lathosterol + NAD(+) => 5alpha-cholest-7-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31026", "l": "squalene <=> dammara-20,24-diene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71334", "l": "chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) <=> chloride(in) + L-phenylalanine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79116", "l": "L-arginine + taurocholate => L-arginocholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30438", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46042", "l": "ADP + dCMP + H(+) => 2'-deoxycytidine + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761344", "l": "USP18 binds IKBKG within IKK complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052806", "l": "sulfite reductase (coenzyme F420) activity", "d": ["Catalysis of the reaction: sulfite + 3 1,5-dihydrocoenzyme F420 = hydrogen sulfide + 3 H2O + 3 coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698677", "l": "HCMV UL36 binds MLKL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51558", "l": "(S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine => (S)-glaucine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655263", "l": "Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5672011", "l": "p-AMPK:AMP binds the ULK complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660662", "l": "ASC binds Caspase-8 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9825783", "l": "p-S207 KARS1 dimer translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58787", "l": "2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 <=> a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429767", "l": "Passive I- efflux mediated by SLC5A8 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682983", "l": "ATM phosphorylates WHSC1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14602", "l": "L-lysine + O2 => 5-aminopentanamide + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729841", "l": "SARS-CoV-2 nsp8 binds to 7SL RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218804", "l": "p38 MAPK activation by VEGFR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73143", "l": "CoA(out) + FAD(in) = CoA(in) + FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52343", "l": "a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] <=> AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50170", "l": "N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11477", "l": "glycerol 1-phosphate + H2O => glycerol + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71630", "l": "phosphate(in) + succinate(out) <=> phosphate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20279", "l": "an N-acetoxyarylamine + CoA => acetyl-CoA + an N-hydroxyarylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75856", "l": "Abortive Initiation Before Second Transition (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49318", "l": "(5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22261", "l": "H2O + triacetate lactone => H(+) + triacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2400001", "l": "AKT1 E17K mutant phosphorylates CHUK (IKKalpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.1.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234166", "l": "Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54277", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 => (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55286", "l": "all-trans-retinyl tetradecanoate + CoA => all-trans-retinol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72122", "l": "(R)-carnitine(in) + glycine betaine(out) <=> (R)-carnitine(out) + glycine betaine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14584", "l": "H(+) + 2 monodehydro-L-ascorbate radical + NADH <=> 2 L-ascorbate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77446", "l": "a ganglioside GT3 + UDP-N-acetyl-alpha-D-galactosamine <=> a ganglioside GT2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357472", "l": "PAK1-3 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694338", "l": "nsp1-4 cleaves itself (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48529", "l": "a ganglioside GP1c (d18:1(4E)) + H2O => a ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854462", "l": "VLDLR binds VLDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74374", "l": "a carboxylate(out) + nicotinate(in) <=> a carboxylate(in) + nicotinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-535717", "l": "Binding of calnexin/calreticulin to the unfolded protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.48", "l": "\"histone acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48158", "l": "a ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate => a ganglioside GQ1b (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45829", "l": "(3R)-hydroxyhexanoyl-CoA + NAD(+) => 3-oxohexanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75858", "l": "9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19828", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-aristolochene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807872", "l": "Active ARF recruits coatomer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447034", "l": "CHL1 interacts with Ankyrin-G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59812", "l": "hexadecanoyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617535", "l": "Activated calmodulin binds ADCY1,ADCY8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60557", "l": "uridine(35) in tRNA(Tyr) => pseudouridine(35) in tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46098", "l": "4 CO2 + 4 CoA + dihydropinosylvin => 3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062072", "l": "H3K9me3 modified histone binding", "d": ["Binding to a histone H3 in which the lysine residue at position 9 has been modified by trimethylation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031738", "l": "XCR1 chemokine receptor binding", "d": ["Binding to a XCR1 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26525", "l": "(2S,3S)-2-methylcitrate <=> 2-methyl-trans-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39847", "l": "a 2-acylglycerol + ATP = a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21683", "l": "(2S)-2-hydroxyphytanate + O2 <=> 2-oxophytanate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674093", "l": "PDGFRs bind type I TKI (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18801", "l": "(cis-prenyl)n-diphosphate + isopentenyl diphosphate = (cis-prenyl)(n+1)-diphosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.20", "l": "\"rubber cis-polyprenylcistransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20629", "l": "H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070080", "l": "titin Z domain binding", "d": ["Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46739", "l": "H2O + monoacyl-sn-glycero-3-phosphate <=> a monoacylglycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16328", "l": "1-phospho-alpha-D-glucuronate + H(+) + UTP <=> diphosphate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850534", "l": "PDCL promotes G-protein beta 5 folding (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043805", "l": "indolepyruvate ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11090", "l": "2 H(+) + triphosphate => H2O + trimetaphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001048", "l": "RNA polymerase IV core binding", "d": ["Binding to RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38692", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35186", "l": "5-hydroxythiophene-2-carbonyl-CoA + H2O <=> 4-carboxy-2-thioxobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49988", "l": "acetone + H(+) + NADPH + O2 = H2O + methyl acetate + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.226", "l": "\"acetone monooxygenase (methyl acetate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061522", "l": "1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity", "d": ["Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75072", "l": "chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in) => chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674427", "l": "PDGFR mutants bind type I TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34112", "l": "carboxyspermidine + H2O + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434650", "l": "MATEs mediate extrusion of xenobiotics (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20680", "l": "alizarin + UDP-alpha-D-glucose <=> 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23777", "l": "ATP + L-aspartate => 4-phospho-L-aspartate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75332", "l": "chloride(out) + D-methionine(out) + 2 Na(+)(out) => chloride(in) + D-methionine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351948", "l": "Mitochondrial recruitment of Drp1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44605", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O => a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12632", "l": "2-oxoglutarate + L-hyoscyamine + O2 <=> (6S)-6-hydroxyhyoscyamine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48546", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine => [phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56286", "l": "a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH => a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50425", "l": "(8Z,11Z,14Z)-eicosatrienoate + 2 O2 => prostaglandin G1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38563", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.90", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55731", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35315", "l": "H(+) + hexadecanoyl-CoA + malonyl-CoA = 3-oxooctadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428696", "l": "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78681", "l": "Sr(2+)(out) => Sr(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40751", "l": "(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate = 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-997237", "l": "SH2B proteins bind JAK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4411402", "l": "Activation of NLK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917700", "l": "MVB Vesicle Formation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60465", "l": "2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004423", "l": "iduronate-2-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662606", "l": "MT3 binds zinc (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16869", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}, {"i": "EC:1.13.11.33", "l": "\"arachidonate 15-lipoxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78836", "l": "3''-dehydropuerarin => 1,5-anhydro-D-erythro-hex-1-en-3-ulose + daidzein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034796", "l": "adipate-CoA ligase activity", "d": ["Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004593", "l": "pantothenase activity", "d": ["Catalysis of the reaction: (R)-pantothenate + H2O = (R)-pantoate + beta-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.104", "l": "\"mannan-binding lectin-associated serine protease-2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295632", "l": "PPA2A dephosphorylates SPRY2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66910", "l": "9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A => acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.11", "l": "\"ribonuclease Z\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27813", "l": "dimethylallyl diphosphate + 2 isopentenyl diphosphate <=> (2Z,6Z)-farnesyl diphosphate + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64873", "l": "D-ribulose 1-phosphate => dihydroxyacetone phosphate + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16003", "l": "IMP + methylamine => H(+) + H2O + N(6)-methyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45996", "l": "a D-alpha-amino acid + a quinone + H2O = a 2-oxocarboxylate + a quinol + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.5.1", "l": "\"D-amino acid dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38031", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) = (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005005", "l": "transmembrane-ephrin receptor activity", "d": ["Combining with a transmembrane ephrin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59288", "l": "beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O = D-glucose + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46880", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796617", "l": "MIB2 binds CFLAR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14101", "l": "[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.29", "l": "\"deoxyhypusine monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27872", "l": "(2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+) => (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24778", "l": "C-13(2)-carboxypyropheophorbide a + methanol => H2O + pheophorbide a", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48700", "l": "H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol = a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443831", "l": "14-3-3-zeta binds Raf1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30470", "l": "(2Z,6Z)-farnesyl diphosphate <=> (+)-endo-beta-bergamotene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10121", "l": "adenosine in double-stranded RNA + H(+) + H2O => inosine in double-stranded RNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47323", "l": "(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate <=> 3-oxo-3-phenylpropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654571", "l": "Activated FGFR1 binds FRS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51689", "l": "galactitol + NAD(+) => H(+) + keto-L-tagatose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693250", "l": "RHOD binds effectors at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112703", "l": "PTPN11 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78554", "l": "Li(+)(in) <=> Li(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264865", "l": "Caspase-mediated cleavage of Lamin A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63774", "l": "1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71782", "l": "4-methyl-2-oxopentanoate(out) + H(+)(out) <=> 4-methyl-2-oxopentanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34065", "l": "2'-deamino-2'-hydroxyparomamine + H(+) + UDP => 2-deoxystreptamine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982017", "l": "Active G alpha (q) binds RGS proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57341", "l": "3-hydroxy-L-kynurenine + S-adenosyl-L-methionine => 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710914", "l": "ALK fusions bind GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35481", "l": "(S)-5'-oxoaverantin + 2 H(+) + NADH => (1'S,5'R)-5'-hydroxyaverantin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664933", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9842655", "l": "IRS1 recruits GRB2 to active LTK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165055", "l": "Hydrolysis of Ran:GTP to Ran:GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805059", "l": "CK2:FACT phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35605", "l": "D-fructose + phosphate => beta-D-fructose 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72246", "l": "catechol + S-adenosyl-L-methionine <=> guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77081", "l": "Formation of the CE:GMP intermediate complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23105", "l": "D-arabinose 5-phosphate => D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35010", "l": "D-fucose(in) <=> D-fucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60581", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174119", "l": "Free APC/C phosphorylated by Plk1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23908", "l": "H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine = 2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine", "d": [], "t": []}, {"i": "EC:1.16.1.8", "l": "\"[methionine synthase] reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76727", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 7-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77092", "l": "ATP + isochorismate + L-glutamate => AMP + diphosphate + H(+) + isochorismoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050374", "l": "UDP-galacturonate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + UDP-alpha-D-galacturonate = CO2 + UDP-L-arabinose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11180", "l": "ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)", "d": [], "t": []}, {"i": "EC:6.1.1.22", "l": "\"asparagine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60071", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 <=> 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30906", "l": "demethylspheroidene + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + spheroidene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.244991688848543", "identifiers": [{"i": "GO:0050840", "l": "extracellular matrix binding", "d": ["Binding to a component of the extracellular matrix."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23360", "l": "L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54137", "l": "cytidine(48) in tRNA precursor + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37855", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexanoyl-CoA = 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78843", "l": "a fatty acid(in) + ATP + H2O = a fatty acid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72734", "l": "UDP-alpha-D-glucose(in) + UMP(out) <=> UDP-alpha-D-glucose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047196", "l": "long-chain-alcohol O-fatty-acyltransferase activity", "d": ["Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52651", "l": "H2O + L-arabino-1,4-lactone 5-phosphate <=> 5-phospho-L-arabinonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66814", "l": "8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B => 5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46617", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38450", "l": "4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O <=> 4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45352", "l": "9,10-epoxyoctadecanoate + H2O = 9,10-dihydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029471", "l": "Hydrolysis of PC to PA by PLD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53933", "l": "O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76638", "l": "n H(+)(out) + Mn(2+)(in) <=> n H(+)(in) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102644", "l": "monocyclic sesterterpenediol synthase activity", "d": ["Catalysis of the reaction: monocyclic sesterterpenediol = all-trans-geranylfarnesol + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68290", "l": "CoA + O-heptanoyl-L-seryl-[protein] => heptanoyl-CoA + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61106", "l": "(2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60411", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O <=> Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6795473", "l": "PDPK1 phosphorylates SGK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706837", "l": "AR binds AR antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27863", "l": "3'-GMP + H2O => guanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39695", "l": "3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH = (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20874", "l": "(20S)-ginsenoside Rb1 + H(+) + UDP => (20S)-ginsenoside Rd + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5213464", "l": "RIPK1 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.127", "l": "\"1,6-alpha-L-fucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32270", "l": "4-aminobutanoate + glyoxylate <=> glycine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57877", "l": "uridine(54) in tRNA => pseudouridine(54) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1183003", "l": "Expression of Leptin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66966", "l": "alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66984", "l": "3-methylbutanoyl-CoA + H2O = 3-methylbutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21507", "l": "acetoin + aldehydo-D-ribose 5-phosphate <=> 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034023", "l": "5-(carboxyamino)imidazole ribonucleotide mutase activity", "d": ["Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22881", "l": "2-oxoglutarate + L-arogenate => L-glutamate + prephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12643", "l": "3-phosphooxypyruvate + H(+) + NADH => (2R)-3-phosphoglycerate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45143", "l": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O <=> CO2 + L-glutamyl-[protein] + O2 + phylloquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814153", "l": "ADO oxidises 2AET to HTAU (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158313", "l": "factor XII -> factor XIIa (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57351", "l": "3-hydroxy-4-methyl-L-kynurenine + H2O <=> 3-hydroxy-4-methylanthranilate + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694334", "l": "mRNA1 is translated to pp1a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823904", "l": "TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57828", "l": "dIMP + H2O = 2-deoxy-D-ribose 5-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140629", "l": "small conductance calcium-activated potassium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a small conductance calcium-activated potassium channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0004252", "l": "serine-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67581", "l": "3'-phosphoadenylyl sulfate + tauro-alpha-muricholate => adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9858589", "l": "DLD dimer dehydrogenates dihydrolipoyl (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004810", "l": "CCA tRNA nucleotidyltransferase activity", "d": ["Catalysis of the reaction: a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76336", "l": "L-aspartate(in) + L-tryptophan(out) => L-aspartate(out) + L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023462", "l": "Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204779", "l": "Interaction of Tie2 with Ang1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21339", "l": "NAD(+) + pyridoxal <=> 4-pyridoxolactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30393", "l": "2-oxoglutaramate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45308", "l": "H(+) + NADPH + prostaglandin D2-ethanolamide = 11beta-prostaglandin F2-ethanolamide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40943", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60343", "l": "N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18140", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17486", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35300", "l": "3-hydroxyoctadecanoyl-CoA + NADP(+) => 3-oxooctadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028519", "l": "NTRK2-activated PI3K generates PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6795473", "l": "PDPK1 phosphorylates SGK1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53919", "l": "an acyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-acyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48505", "l": "D-glycero-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-D-manno-heptose 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912396", "l": "NICD1 binds HIF1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30124", "l": "H2O + tetradecanoyl-[ACP] => H(+) + holo-[ACP] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561072", "l": "OCT3 mediates renal uptake of organic cations (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102536", "l": "sakuranetin 6-hydroxylase activity", "d": ["Catalysis of the reaction: sakuranetin + O2 + NADPH + H+ = carthamidin-7-methyl ether + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13505", "l": "choline + O2 = betaine aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60950", "l": "(S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine => (S)-eriodictyol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008401", "l": "retinoic acid 4-hydroxylase activity", "d": ["Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391372", "l": "GNRHR binds GNRH1,2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71260", "l": "2 Na(+)(out) + phosphate(out) => 2 Na(+)(in) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72210", "l": "chloride(out) + 2 hydrogencarbonate(in) <=> chloride(in) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11749", "l": "fluoroacetaldehyde + L-threonine => 4-fluoro-L-threonine + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.5.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12846", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O => [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25667", "l": "(2E)-geranyl diphosphate => beta-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68068", "l": "a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671702", "l": "AP1G2 binds HGS and CHMP2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77440", "l": "a ganglioside GQ1c + H2O => a ganglioside GT1c + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72359", "l": "glutarate(in) + succinate(out) = glutarate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11458", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102097", "l": "(22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity", "d": ["Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + O2 + NADPH + H+ = 3-dehydro-6-deoxoteasterone + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69737", "l": "2-phenylsuccinyl-CoA + succinate => phenylsuccinate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983194", "l": "Kinesin-1 is a heterotetramer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67747", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O <=> 1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63405", "l": "3,6-dichloropyridine-2,5-diol + FADH2 + O2 => 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14367", "l": "CO2 + L-aspartate + NH4(+) => 2 H(+) + H2O + N-carbamoyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20391", "l": "(2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+) => (2R,3R)-dihydroquercetin + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848751", "l": "PTK6 binds AKT1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795667", "l": "MDM2 translocates to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20216", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] <=> L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39358", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH <=> (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45736", "l": "(3E)-hexenoyl-CoA = (2E)-hexenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52598", "l": "3-oxocholan-24-oyl-CoA + H(+) + NADH => lithocholoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008884", "l": "glutathionylspermidine amidase activity", "d": ["Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38133", "l": "1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72672", "l": "6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2 => 1,6-dihydroxyphenazine + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803047", "l": "DCD peptide binds bacterial membrane phospholipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008577", "l": "IL37:IL18R1 binds SIGIRR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53707", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O <=> H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72015", "l": "acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine = 2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.8.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3244643", "l": "STING binds cyclic GMP-AMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40122", "l": "H2O + tetradecanoyl-CoA <=> CoA + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72591", "l": "D-glucuronate(out) + H(+)(out) = D-glucuronate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0070717", "l": "poly-purine tract binding", "d": ["Binding to a stretch of purines (adenine or guanine) in an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389354", "l": "Activation of Vav1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183126", "l": "Factor B binds to surface-associated C3b (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794352", "l": "NRXNs binds CASK tripartite complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23296", "l": "aceneuramate = N-acetyl-D-mannosamine + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.3", "l": "\"N-acetylneuraminate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10719", "l": "D-glucose 6-phosphate <=> 1D-myo-inositol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045031", "l": "G protein-coupled ATP receptor activity", "d": ["Combining with ATP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50707", "l": "1-propanol + NAD(+) <=> H(+) + NADH + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.117", "l": "\"stratum corneum chymotryptic enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41609", "l": "3'-phosphoadenylyl sulfate + alpha,alpha-trehalose => 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102527", "l": "8-demethylnovobiocate synthase activity", "d": ["Catalysis of the reaction: 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP(4-) = H+ + 8-desmethylnovobiocic acid(1-) + AMP(2-) + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54075", "l": "(2E)-geranyl diphosphate <=> beta-thujene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710254", "l": "GSDME oligomerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29978", "l": "2'-deoxycytidine(in) + H(+)(in) <=> 2'-deoxycytidine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340214", "l": "CYGB binds O2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086083", "l": "cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication", "d": ["Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332356", "l": "CAMK2 binds MAP3K7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10700", "l": "H2O + limonene 1,2-epoxide = limonene-1,2-diol", "d": [], "t": []}, {"i": "EC:3.3.2.8", "l": "\"limonene-1,2-epoxide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64194", "l": "(9Z)-octadecenoate + L-lysine => H2O + N-(9Z-octadecenoyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72906", "l": "butyrolactone II + dimethylallyl diphosphate <=> butyrolactone I + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53609", "l": "4-hydroxyestrone + O2 => (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48679", "l": "6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20885", "l": "H2O + L-serine + NAD(+) => 3-hydroxypyruvate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102762", "l": "eriodictyol 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine = H+ + hesperetin(1-) + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388811", "l": "CD28 homodimer binds B7-1 homodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60110", "l": "(E)-4-coumaroyl-CoA + H2O => (R)-3-(4-hydroxyphenyl)lactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74076", "l": "H(+) + NADH + phylloquinone => NAD(+) + phylloquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52942", "l": "chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP => chenodeoxycholate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72267", "l": "chloride(out) + formate(in) = chloride(in) + formate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50332", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] = 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45695", "l": "N-(octanoyl)-sphing-4-enine-1-phosphate(in) <=> N-(octanoyl)-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21514", "l": "2-dehydro-3-deoxy-L-galactonate => 3,6-anhydro-L-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23326", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide => 2'-phospho-[ligated tRNA] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604368", "l": "Autocatalytic activation of bound proMMP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694442", "l": "CNIH2,3 bind GRIA1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16151", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide => beta-nicotinamide D-ribonucleotide + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54158", "l": "[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061923", "l": "(2S,3R,6S,9S)-(-)-protoillud-7-ene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (2S,3R,6S,9S)-(-)-protoillud-7-ene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45999", "l": "a D-alpha-amino acid + a quinone + H2O <=> a 2-oxocarboxylate + a quinol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12852", "l": "H2O + O-phospho-L-seryl-[myosin light chain] <=> L-seryl-[myosin light chain] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757578", "l": "ALB binds PREDN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24913", "l": "L,L-cystathionine <=> 2-aminobut-2-enoate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015494", "l": "aromatic amino acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187575", "l": "Ubiquitination of phospho-p27/p21 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848774", "l": "PTK6 binds DOK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24103", "l": "diisopropyl fluorophosphate + H2O <=> diisopropyl phosphate + fluoride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29822", "l": "ATP + H2O + L-isoleucine(out) <=> ADP + H(+) + L-isoleucine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696997", "l": "USP24 deubiquitinates DDB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692539", "l": "HRH1 binds HRH1 inverse agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709317", "l": "CO binds to free ferrohemoglobin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23559", "l": "D-alanine + L-glutamine <=> gamma-L-glutamyl-D-alanine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.27", "l": "\"4-aminobenzoate 1-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45111", "l": "(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] <=> 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34258", "l": "sporulenol <=> (R)-tetraprenyl-beta-curcumene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015346", "l": "ferric triacetylfusarinine C:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51921", "l": "a quinone + AH2 => A + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55595", "l": "2 (3R)-hydroxydecanoyl-[ACP] + H2O <=> (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130706", "l": "MHC class II antigen processing (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21589", "l": "N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate => H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070012", "l": "oligopeptidase activity", "d": ["Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42249", "l": "butanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxohexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30171", "l": "hexadecanoyl-[ACP] + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74749", "l": "3-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine => myricetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634433", "l": "CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706364", "l": "Internalization of ubiquitinated FLT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65102", "l": "an hexadecanoyl-acylglycerol + CoA => a 1-acylglycerol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754978", "l": "Unknown kinase phosphorylates RBV-MP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29416", "l": "(S)-lactate(in) + H(+)(in) => (S)-lactate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59465", "l": "NADP(+) + octadecan-1-ol => H(+) + NADPH + octadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19825", "l": "(2E,6E)-farnesyl diphosphate = (+)-aristolochene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.9", "l": "\"aristolochene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350651", "l": "Caspase-mediated cleavage of MASK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482892", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2G4C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34744", "l": "15-methylhexadecasphinganine 1-phosphate => 13-methyltetradecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29182", "l": "a menaquinol + 2 O2 <=> a menaquinone + 2 H(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28213", "l": "H2O + L-saccharopine + O2 <=> (S)-2-amino-6-oxohexanoate + H2O2 + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376419", "l": "Formation of NR-MED1 Coactivator Complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37491", "l": "4-coumaroyl-CoA + S-adenosyl-L-methionine = CoA + H(+) + N-(4-coumaroyl)-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.3.1.229", "l": "\"4-coumaroyl-homoserine lactone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350377", "l": "Extracellular domains of STAN bind to each other in adjacent cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78599", "l": "acetyl-CoA + octadecanoyl-CoA = 3-oxoeicosanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68195", "l": "decanoyl-CoA + phytol <=> CoA + decanoate phytyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35965", "l": "fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858346", "l": "AMHR2 binds AMH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032426", "l": "NTRK2 phosphorylates FRS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16299", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH => 5alpha-androstane-3beta,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11816", "l": "alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.9", "l": "\"glucose-6-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034191", "l": "apolipoprotein A-I receptor binding", "d": ["Binding to an apolipoprotein A-I receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62838", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24030", "l": "carnitine + CO2 + succinate => 2-oxoglutarate + 4-(trimethylamino)butanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693111", "l": "RHOF auto-activates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35124", "l": "H(+)(out) + L-alanyl-D-glutamate(out) => H(+)(in) + L-alanyl-D-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42660", "l": "NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": [], "t": []}, {"i": "EC:1.1.1.374", "l": "\"UDP-N-acetylglucosamine 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45052", "l": "(2E)-butenoyl-CoA + (R)-carnitine = CoA + O-(2E)-butenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62805", "l": "2 7-demethylsiderin + NADPH + O2 => desertorin A + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047692", "l": "ATP deaminase activity", "d": ["Catalysis of the reaction: ATP + H2O = ITP + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.1", "l": "\"microtubule-severing ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0017069", "l": "snRNA binding", "d": ["Binding to a small nuclear RNA (snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49518", "l": "an adenosine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11779", "l": "2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] <=> (9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50586", "l": "15-oxoprostaglandin E1 + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050455", "l": "columbamine oxidase activity", "d": ["Catalysis of the reaction: 2 columbamine + O2 = 2 berberine + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17106", "l": "malonyl-[ACP] + S-adenosyl-L-methionine => malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731141", "l": "Syndecan-1 binds fibronectin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58029", "l": "5 (S)-methylmalonyl-CoA + a medium-chain fatty acyl-CoA + 32 H(+) + 5 malonyl-CoA + 22 NADPH => a mycoketide-CoA + 10 CO2 + 10 CoA + 11 H2O + 22 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102544", "l": "ornaline synthase activity", "d": ["Catalysis of the reaction: L-ornithinium(1+) + 2-oxoglutarate + NADPH + H+ = ornaline + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27894", "l": "3'-CMP + H2O = cytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64390", "l": "4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => 4 A + sn-3-O-phytanylglycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798372", "l": "ATM phosphorylates DYRK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19959", "l": "2 9-riburonosylhypoxanthine + 2 H(+) => 2 5'-dehydroinosine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19341", "l": "2 H(+) + O2 + octane + 2 reduced [rubredoxin] = H2O + octan-1-ol + 2 oxidized [rubredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.3", "l": "\"alkane 1-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11647", "l": "a (2R,3R)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021050", "l": "HSBP1 oligomer binds ESRs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995388", "l": "PP2A dephosphorylates BANF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062152", "l": "mRNA (cytidine-5-)-methyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H+ + S-adenosyl-L-homocysteine."], "t": []}, {"i": "RHEA:61464", "l": "a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64507", "l": "AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine <=> 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24749", "l": "L-methionine <=> 2-aminobut-2-enoate + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57201", "l": "glyoxal + L-arginyl-[protein] => N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12324", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = L-asparagine + N-acetyl-D-glucosamine", "d": [], "t": []}, {"i": "EC:3.2.2.11", "l": "\"beta-aspartyl-N-acetylglucosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030697", "l": "tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + uridine54 in tRNA = 5-methyluridine54 in tRNA + H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21127", "l": "cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50965", "l": "cytidine(8) in tRNA + H(+) + H2O => NH4(+) + uridine(8) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0086089", "l": "voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428260", "l": "DEGS2 oxygenates dihydroceramide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24221", "l": "beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] => (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429815", "l": "Formation Of Bloc-1 Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19011", "l": "a carboxylate + H(+) + pyruvate => a 3-acylpyruvate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10193", "l": "ATP + H2O + sulfate(out) => ADP + H(+) + phosphate + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37682", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047062", "l": "trans-acenaphthene-1,2-diol dehydrogenase activity", "d": ["Catalysis of the reaction: (+-)-trans-acenaphthene-1,2-diol + 2 NADP+ = acenaphthene-1,2-dione + 2 H+ + 2 NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690196", "l": "USP8 deubiquitinates RNF128 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696183", "l": "AOC3 deaminates BZAM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390141", "l": "D inhibits WTS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76136", "l": "a dicarboxylate(in) + urate(out) => a dicarboxylate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67883", "l": "3'-phosphoadenylyl sulfate + dopamine <=> adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734697", "l": "Expression of SMYD1 (BOP) in cardiogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19889", "l": "alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose", "d": [], "t": []}, {"i": "EC:2.7.7.9", "l": "\"UTP--glucose-1-phosphate uridylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201457", "l": "BMP2 binds to the receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40359", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59882", "l": "3,4-dihydroxyphenylacetate + FMN + H(+) + H2O => 4-hydroxyphenylacetate + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64517", "l": "2-hydroxyethane-1-sulfonate + NAD(+) => H(+) + NADH + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59553", "l": "N,N',N'',N'''-tetraacetylchitotetraose + O2 => H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17547", "l": "[protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin] => [protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51534", "l": "5-hydroxyisourate + H2O + NADP(+) => H(+) + NADPH + O2 + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015055", "l": "secretin receptor activity", "d": ["Combining with secretin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701147", "l": "TRPV1 binds TRPV1 blockers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429683", "l": "CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007646", "l": "CBX5 gene expression is inhibited by E2F6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28105", "l": "GDP-alpha-D-mannose + H2O <=> D-mannose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29920", "l": "alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP => ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61451", "l": "H(+) + NADPH + O2 + tigecycline <=> 11a-hydroxytigecycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769394", "l": "AKT phosphorylates CBY1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67616", "l": "8-oxo-GTP + H2O = 8-oxo-GMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72378", "l": "hydrogencarbonate(out) + iodide(in) <=> hydrogencarbonate(in) + iodide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5579018", "l": "NCOA1(868-1441) binds PAX3(1-319) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40100", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA => 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141192", "l": "ATP:ATP adenylyltransferase activity", "d": ["Catalysis of the reaction: 2 ATP + H+ = diphosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate."], "t": []}, {"i": "RHEA:34935", "l": "2 ATP + H(+) = diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047642", "l": "aldose beta-D-fructosyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74784", "l": "tyramine(in) => tyramine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72930", "l": "O2 + proatranorin I + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin IV", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389849", "l": "28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54785", "l": "Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide => Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57650", "l": "equisetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trichosetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18541", "l": "10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine = dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.119", "l": "\"10-hydroxydihydrosanguinarine 10-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31571", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 = CO2 + H2O + NADP(+) + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48269", "l": "4',4'-dihydroxyechinenone => canthaxanthin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73186", "l": "ADP(in) + FAD(out) <=> ADP(out) + FAD(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13115", "l": "H(+) + N-hydroxy-2-acetamidofluorene + NADPH => 2-acetamidofluorene + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203973", "l": "Vesicle budding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769249", "l": "NPAS4 stimulates SYT10 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45345", "l": "a globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => a globoside NORint (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674529", "l": "AAMP binds to TBXA2R (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53460", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4395236", "l": "TP53 binds promoters of MIR34 genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022368", "l": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-42) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351948", "l": "Mitochondrial recruitment of Drp1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40090", "l": "22-hydroxydocosanoate + NAD(+) <=> 22-oxodocosanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390909", "l": "HRH2 binds hist (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78187", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49325", "l": "(5R,6S)-5,6-epoxi-capsanthin => all-trans-capsorubin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44256", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36659", "l": "carbamoyl phosphate + descarbamoylnovobiocin = novobiocin + phosphate", "d": [], "t": []}, {"i": "EC:2.1.3.12", "l": "\"decarbamoylnovobiocin carbamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237160", "l": "MTA is cleaved and phosphorylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140752", "l": "branched 1,3-beta-D-glucan synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a branched [(1->3)-beta-D-glucosyl](n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.405", "l": "\"ribitol-5-phosphate 2-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749647", "l": "CES2 hydrolyzes ASA- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13382", "l": "acetate + an acyl-CoA => a carboxylate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209336", "l": "Activated HOP is autophosphorylated and/or transphosphorylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33352", "l": "hexacosanoyl-CoA + sphinganine => CoA + H(+) + N-hexacosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9035227", "l": "TXN2 binds CysS248-MPST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684340", "l": "3CLp cleaves pp1ab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928631", "l": "GIT1 binds bPIX (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418904", "l": "A1 and A3 receptors bind adenosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36490", "l": "agmatine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + N(1)-(3-aminopropyl)agmatine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49512", "l": "2-(phosphinatomethylidene)butanedioate + H2O = phosphinomethylisomalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75888", "l": "ADP-1-deoxy-1,O(4)-didehydro-D-ribose + L-arginyl-[protein] => ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73437", "l": "H(+) + H2O + ladanein + oxidized [NADPH--hemoprotein reductase] => apigenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008201", "l": "heparin binding", "d": ["Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45461", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762343", "l": "PREDL:ALB dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938930", "l": "RUNX1 binds ELF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68624", "l": "phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]", "d": [], "t": []}, {"i": "EC:4.4.1.39", "l": "\"C-phycoerythrin alpha-cysteine-82 phycoerythrobilin lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13739", "l": "an alk-2-enal + H(+) + NADPH => an n-alkanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800794", "l": "PIDD1 associates with CRADD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395768", "l": "LPL hydrolyses TGs from mature CMs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19980", "l": "3'-phosphoadenylyl sulfate + L-tyrosine methyl ester <=> adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222469", "l": "SodC reduces superoxide to H2O2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-874087", "l": "SGT1 binds HSP90 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12314", "l": "2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+) => dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12941", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.143", "l": "\"alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64628", "l": "acetyl-CoA + octan-1-ol = CoA + octyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18875", "l": "chloride + H(+) + NH4(+) + pyruvate => 3-chloro-D-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32581", "l": "(1R,5R)-beta-pinene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47715", "l": "trans-3-hydroxy-L-proline <=> cis-3-hydroxy-D-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373717", "l": "DCC interacts with DIP13alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65541", "l": "a ganglioside GM3 + H2O => an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047481", "l": "D-alanine-alanyl-poly(glycerolphosphate) ligase activity", "d": ["Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77862", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-phenylalanine + O2 <=> (2S)-3-phenyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043919", "l": "agmatine aminopropyltransferase activity", "d": ["Catalysis of the reaction: agmatine + S-adenosylmethioninamine = N1-aminopropylagmatine + 5'-methylthioadenosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67766", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46525", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202111", "l": "AKT1 phosphorylates eNOS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9669893", "l": "KIT binds type I TKIs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11906", "l": "2,4-dihydroxypteridine + NH4(+) => 2-amino-4-hydroxypteridine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428625", "l": "Vesicular inhibitory amino acid transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15862", "l": "3-ADP-2-phosphoglycerate + H2O => 3-ADP-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28894", "l": "H(+)(in) + putrescine(in) <=> H(+)(out) + putrescine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71875", "l": "2 Na(+)(out) + taurocholate(out) = 2 Na(+)(in) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.16", "l": "\"tRNA-intron lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653957", "l": "Rag dimer formation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12079", "l": "an aromatic primary alcohol + NAD(+) <=> an aromatic aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61145", "l": "myricetin + UDP-beta-L-rhamnose => H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336184", "l": "GPR37L binds prosaposin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592316", "l": "Initial activation of proMMP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38066", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA <=> 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033444", "l": "AAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75159", "l": "NAD(+) + TTP = H(+) + NADP(+) + TDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47666", "l": "2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65571", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20639", "l": "D-glucono-1,5-lactone + D-sorbitol => D-fructose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55053", "l": "H2O + pentanoyl-CoA => CoA + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009378", "l": "four-way junction helicase activity", "d": ["Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018826", "l": "RHOT2 hydrolyzes GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66218", "l": "asc-DeltaC7-CoA + H2O2 => asc-C7-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13838", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) => 4,5-dihydroxyphthalate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73318", "l": "1D-chiro-inositol(out) + 2 Na(+)(out) <=> 1D-chiro-inositol(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2471842", "l": "Collagen type XXV ectomain shedding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71709", "l": "H(+)(in) + L-phenylalanyl-L-phenylalanine(in) => H(+)(out) + L-phenylalanyl-L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693540", "l": "MRN activates ATM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64198", "l": "a fatty acid + L-lysine => an N-(fatty acyl)-L-lysine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10883", "l": "7-methylxanthosine + H2O <=> 7-methylxanthine + D-ribose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047019", "l": "indole-3-acetaldehyde reductase (NADPH) activity", "d": ["Catalysis of the reaction: indole-3-ethanol + NADP+ = (indol-3-yl)acetaldehyde + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16532", "l": "ADP + H(+) + sulfate <=> adenosine 5'-phosphosulfate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23049", "l": "(S)-3-hydroxybutanoate + 2-oxoglutarate => (R)-2-hydroxyglutarate + acetoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1591234", "l": "ZBP1 binds cytosolic DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202960", "l": "Caspase mediated cleavage of C-IAP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64854", "l": "CoA + octyl benzoate => benzoyl-CoA + octan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648268", "l": "HTR1A binds HTR1A antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38896", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29642", "l": "D-maltohexaose + H2O <=> alpha-D-glucose + D-maltopentaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67547", "l": "(9Z)-tetradecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46606", "l": "[HPr protein]-L-serine + diphosphate => [HPr protein]-O-phospho-L-serine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46871", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli) <=> a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66978", "l": "alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+) => alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25069", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54608", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25875", "l": "H2O2 + pyridine <=> H2O + pyridine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39732", "l": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36090", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166219", "l": "FA anion picks up a proton (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036193", "l": "2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity", "d": ["Catalysis of the reaction: 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] = DIBOA + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736959", "l": "WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163432", "l": "cholesterol ester + H2O -> cholesterol + fatty acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49730", "l": "CO2 + 2 H2O + NADP(+) + violacein => 2 H(+) + NADPH + 2 O2 + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44890", "l": "1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.121", "l": "\"polymannuronate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69453", "l": "3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH => 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53757", "l": "allodeoxycholoyl-CoA + cholate => allodeoxycholate + choloyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944483", "l": "miR-17 microRNA binds PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848873", "l": "PTK6 phosphorylates ARAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44338", "l": "ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate => an L-alpha-amino acid + ATP + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20058", "l": "2 H(+) + H2O + N-carbamoylsarcosine => CO2 + NH4(+) + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13186", "l": "H2O + 4 porphobilinogen => hydroxymethylbilane + 4 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31399", "l": "all-trans-4,4'-diapophytofluene + FAD + H(+) = all-trans-4,4'-diapo-zeta-carotene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25439", "l": "(2E,6E)-farnesyl diphosphate <=> (E,R)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430158", "l": "p-SLP-76 binds VAV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234179", "l": "Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23000", "l": "(R)-pantoate + NAD(+) = (R)-4-dehydropantoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.106", "l": "\"pantoate 4-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19731", "l": "acetone + CO2 => acetoacetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839388", "l": "TGFBR3 translocation to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.352", "l": "\"5'-hydroxyaverantin dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78701", "l": "a beta-D-glucuronoside + alpha-D-glucose 1-phosphate => a 3-O-beta-D-glucosyl-beta-D-glucuronoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18274", "l": "H2O + O2 + putrescine => 4-aminobutanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450550", "l": "PKCalpha phosphorylates HuR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42653", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine => diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392749", "l": "Transport of L1 into endosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71357", "l": "5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in) => 5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592278", "l": "Autocatalytic activation of proMMP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002170", "l": "high-affinity IgA receptor activity", "d": ["Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31069", "l": "Delta(1)-piperideine-2-carboxylate + H2O => 6-amino-2-oxohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10094", "l": "a 2'-deoxyribonucleoside + phosphate => a 2'-deoxyribonucleoside 3'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64548", "l": "N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] = (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23567", "l": "2 columbamine + O2 <=> 2 berberine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71143", "l": "3-hydroxyhispidin + O2 = (E)-caffeoylpyruvate + CO2 + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8963851", "l": "VD3 dissociates from GC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033952", "l": "iota-carrageenase activity", "d": ["Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45479", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818682", "l": "MEN1 binds MLL2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72621", "l": "Ribosomal scanning  (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.128", "l": "\"7-methylxanthine demethylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53043", "l": "4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418662", "l": "Src activation following P2Y purinoceptor activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9823939", "l": "IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57739", "l": "A + all-trans-3,4-didehydro-13,14-dihydroretinol <=> AH2 + all-trans-3,4-didehydroretinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11250", "l": "(R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41357", "l": "bacteriochlorophyll a + 3 NADP(+) => geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.10", "l": "\"adenosylcobinamide-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63701", "l": "mycophenolate + UDP-alpha-D-glucuronate => mycophenolic acid O-acyl-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45313", "l": "NADP(+) + prostaglandin F2alpha => H(+) + NADPH + prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34310", "l": "4-nitrocatechol + NADPH + O2 <=> 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10312", "l": "H(+) + NADH + O2 + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.15", "l": "\"terephthalate 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66976", "l": "alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose = alpha-D-Abe-(1->3)-alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.382", "l": "\"CDP-abequose:alpha-L-Rha2OAc-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40941", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+) => 1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211651", "l": "Cleavage of PAK-2 at 212 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60292", "l": "L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.356", "l": "\"[histone H3]-lysine(27) N-trimethyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757574", "l": "ALB binds PREDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47647", "l": "adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62081", "l": "D-glucose 6-sulfate + NADP(+) => 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46001", "l": "adenosine + H(+) + tuberculosinyl diphosphate => 1-tuberculosinyladenosine + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15621", "l": "an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.122", "l": "\"N-acetylgalactosaminide beta-1,3-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32808", "l": "thiosulfate(in) => thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36988", "l": "CMP + phosphate => alpha-D-ribose 1,5-bisphosphate + cytosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327733", "l": "FN1 binds Collagen types I-V, VII (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635102", "l": "GPR161 is internalized (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727857", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PKL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31569", "l": "2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+) => bisphenol A + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35730", "l": "dodecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-dodecanoyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76315", "l": "L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114552", "l": "Thrombin-activated PARs activate G12/13 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805479", "l": "TP53RK phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62268", "l": "(R)-2-hydroxy-3-methylbutyrate + NADP(+) = 3-methyl-2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24085", "l": "all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59687", "l": "D-maltohexaose + O2 <=> D-maltohexaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60064", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229343", "l": "AXIN is phosphorylated in the destruction complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417825", "l": "P2Y11 receptor can bind to ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41045", "l": "1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16426", "l": "formaldehyde + H2O + NAD(+) => formate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77829", "l": "2-dehydro-D-glucose + L-alanine => (2S)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53859", "l": "NADP(+) + ursocholate <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52615", "l": "3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029273", "l": "PI3K binds to p-6Y-SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43598", "l": "3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde => (3R)-3-hydroxy-8'-apo-beta-carotenal + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72031", "l": "(E)-sinapyl alcohol + O2 = (E)-sinapaldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60765", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone => cinerin II + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70284", "l": "H2O + N-acetylputrescine + O2 => 4-acetamidobutanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211219", "l": "Translocation of caspase-3 to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21221", "l": "L-dopa + O2 => 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17084", "l": "(E)-isoeugenol + S-adenosyl-L-methionine <=> (E)-isomethyleugenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36458", "l": "ATP + H2O + L-alanylglycine(out) <=> ADP + H(+) + L-alanylglycine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047766", "l": "carbamoyl-serine ammonia-lyase activity", "d": ["Catalysis of the reaction: O-carbamoyl-L-serine + H2O + H+ = CO2 + 2 NH4 + pyruvate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9646468", "l": "mTORC1 binds RHEB:GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50637", "l": "a 3-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429415", "l": "SYK binds to integrin alphaIIb beta3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21094", "l": "dihydromacarpine + H(+) + S-adenosyl-L-homocysteine => 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31990", "l": "(S)-2,3-epoxysqualene <=> baruol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450054", "l": "Interleukin-2 receptor alpha binds interleukin-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9822532", "l": "ADAMTS13 cleaves VWF multimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649108", "l": "HTR3A pentamer binds 5HT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77052", "l": "3,5-dimethylcyclohexanamine + H2O + NADP(+) => 3,5-dimethylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003944", "l": "N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity", "d": ["Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696358", "l": "TREM,CD300 binds lipids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9656947", "l": "OGG1beta translocates to mitochondria (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14794", "l": "2-hydroxyadipate + NAD(+) => 2-oxoadipate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.139", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.36", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15792", "l": "L-xylose + NADP(+) <=> H(+) + L-xylono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31800", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + H2O => 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140262", "l": "mRNA cap binding complex binding", "d": ["Binding to a mRNA cap binding complex."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48361", "l": "a 1,2-saturated fatty acid + H2O2 => a 2-hydroxy fatty acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48430", "l": "(9Z,12Z)-octadecadienoate + glycerol + H(+) => 1-(9Z,12Z-octadecadienoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50114", "l": "CoA + H(+) + N-octadecanoyl-taurine => octadecanoyl-CoA + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805126", "l": "AURKB phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11422", "l": "H2O + NADP(+) + senecionine N-oxide => NADPH + O2 + senecionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62815", "l": "4 monapinone A + O2 <=> 2 dinapinone A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949276", "l": "RUNX3:CBFB binds the RORC gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44247", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24975", "l": "calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10981", "l": "L-serine => D-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218836", "l": "PTK2beta binds alphaVbeta3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68675", "l": "16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77497", "l": "(2S)-2-hydroxy-2-phenylpropanenitrile => acetophenone + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22202", "l": "(E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + trans-aconitate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74963", "l": "L-leucine(out) + L-ornithine(in) + Na(+)(out) = L-leucine(in) + L-ornithine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013110", "l": "RHOC binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047821", "l": "D-glutamate oxidase activity", "d": ["Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0052615", "l": "ent-kaurene oxidase activity", "d": ["Catalysis of the reaction: H+ + NADPH + ent-kaur-16-ene + oxygen = H2O + NADP+ + ent-kaur-16-en-19-ol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373342", "l": "CX3CR1 binds CX3CL1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55678", "l": "(2S)-2-amino-4-deoxychorismate + H2O => chorismate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950260", "l": "Expression of Proteasome activator complex subunit 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55431", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30889", "l": "7,8-dihydropteroate + H2O => 4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36275", "l": "H(+) + NADPH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59830", "l": "inosine + L-homocysteine => H2O + S-inosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71485", "l": "L-phenylalanyl-L-methionine + L-tyrosylglycylglycine => H2O + Met-enkephalin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031402", "l": "sodium ion binding", "d": ["Binding to a sodium ion (Na+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74995", "l": "epierythrostominol(in) = epierythrostominol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68436", "l": "(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 = (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44578", "l": "2-all-trans-nonaprenylphenol + CO2 => 4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0070002", "l": "glutamic-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31181", "l": "3-oxododecanoyl-CoA + H(+) + NADH => (3S)-3-hydroxydodecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36342", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32310", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> H2O + leukotriene A4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26030", "l": "H2O + N(1)-acetylspermidine + O2 <=> 3-aminopropanal + H2O2 + N-acetylputrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050086", "l": "mannitol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21727", "l": "a nitrile + 2 H2O <=> a carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.1", "l": "\"aldehyde oxidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625465", "l": "E2-mediated FOS gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78732", "l": "(3S)-hydroxyeicosanoyl-CoA + NAD(+) => 3-oxoeicosanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917987", "l": "TFRC dimer binds 2xholoTF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78238", "l": "D-isoleucine + H2O + O2 <=> (R)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2399913", "l": "atRAL binds to RBP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432825", "l": "HMGB1 binds TLR4:LY96 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159771", "l": "Furin cleaves pro-protein C to protein C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21399", "l": "(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) <=> CO2 + Na(+)(out) + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54122", "l": "coelenterazine h dioxetanone => coelenterazine h + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14828", "l": "(1R,5S)-carveol + NAD(+) <=> (S)-carvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15014", "l": "3alpha(S)-strictosidine + H2O => secologanin + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70979", "l": "MDH2 dimer dehydrogenates MAL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9796617", "l": "MIB2 binds CFLAR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9670014", "l": "Factor VIIIa dissociates  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798528", "l": "S100A8:S100A9 binds Mn2+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45763", "l": "dTDP-beta-L-daunosamine + epsilon-rhodomycinone <=> dTDP + H(+) + rhodomycin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17229", "l": "acetyl-CoA + an aliphatic alcohol = an acetyl ester + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.84", "l": "\"alcohol O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864466", "l": "TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70779", "l": "D-glucose + NADP(+) = 6-dehydro-D-glucose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.432", "l": "\"6-dehydroglucose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931974", "l": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251944", "l": "PLCG1 binds to p-ERBB2:p-EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75079", "l": "24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21717", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74380", "l": "2 (S)-lactate(in) + prostaglandin H2(out) => 2 (S)-lactate(out) + prostaglandin H2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176942", "l": "Multiple proteins are localized at replication fork (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10025", "l": "L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804276", "l": "ATM phosphorylates TTC5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931981", "l": "RUNX1 binds ESR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12253", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + H2O => (E)-coniferol + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380042", "l": "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70253", "l": "cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine => beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78786", "l": "luteolin + UDP-alpha-D-glucose <=> H(+) + isoorientin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66105", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31042", "l": "dodecanoyl-CoA + FAD + H(+) <=> (2E)-dodecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10280", "l": "1,7-dimethylxanthine + S-adenosyl-L-methionine = caffeine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229132", "l": "AP4 binds APP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46192", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42428", "l": "clavaminate = (3R,5R)-clavulanate-9-aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14713", "l": "A + keto-L-sorbose = 5-dehydro-D-fructose + AH2", "d": [], "t": []}, {"i": "EC:1.1.99.12", "l": "\"sorbose dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850534", "l": "PDCL promotes G-protein beta 5 folding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299359", "l": "Activation of TALK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014467", "l": "RHOG binds effectors at the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69256", "l": "H2O + progoitrin = (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39734", "l": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62862", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O => acetyl-CoA + 7 H(+) + 7 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60471", "l": "3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) <=> 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034791", "l": "isobutylamine N-hydroxylase activity", "d": ["Catalysis of the reaction: isobutylamine + NADPH + O2 = isobutylhydroxylamine + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981093", "l": "IL12 bound to IL12R internalises (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013159", "l": "CDC42 GEFs activate CDC42 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-383190", "l": "HCO3- transport through ion channel (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73757", "l": "Binding of RRN3 to RNA Polymerase I (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73625", "l": "CTP(in) + GDP(out) => CTP(out) + GDP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60962", "l": "(9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP => 18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36894", "l": "(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534206", "l": "E-cadherin degradation by PS1:NCSTN (Gamma-secretase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68209", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol => 1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1235037", "l": "Expression of VEGFA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68747", "l": "2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867613", "l": "PICALM binds R-SNAREs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43741", "l": "ATP + CoA + hexanoate => AMP + diphosphate + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45384", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70476", "l": "2 S-adenosyl-L-methionine + sphing-4-enine => 2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22200", "l": "S-adenosyl-L-methionine + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.145", "l": "\"trans-aconitate 3-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621010", "l": "HOXB1 activates HOXA2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53490", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NADP(+) => 11beta-hydroxyandrost-4-ene-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120319", "l": "long-chain fatty acid omega-1 hydroxylase activity", "d": ["Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}, {"i": "RHEA:60936", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48652", "l": "lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16454", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O => 2-formylbenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694409", "l": "Nucleotide exchange on RAB1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2318373", "l": "Defective GUSB does not hydrolyse (HA)2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4411383", "l": "NLK phosphorylates TCF/LEF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025007", "l": "Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656356", "l": "Defective SLC5A1 does not cotransport Glc and Na+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948709", "l": "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53879", "l": "a cytidine in tRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54408", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25951", "l": "a 1,2-diacyl-sn-glycerol + CTP <=> a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10152", "l": "ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate + H(+) + H2O", "d": [], "t": []}, {"i": "EC:2.7.2.2", "l": "\"carbamate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000120", "l": "CBLIF binds RCbl (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48372", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029460", "l": "PAK1 phosphorylates LIMK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51363", "l": "H2O + N-(9Z-octadecenoyl)-L-leucine <=> (9Z)-octadecenoate + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50006", "l": "11a-hydroxytetracycline + H2O + NADP(+) => H(+) + NADPH + O2 + tetracycline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33400", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) => L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050429", "l": "calcium-dependent phospholipase C activity", "d": ["Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48961", "l": "[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide => [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042284", "l": "sphingolipid delta-4 desaturase activity", "d": ["Catalysis of the reaction: a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ -> a sphingosine ceramide (aka (4E)-sphing-4-enine ceramide) + 2 ferricytochrome b5 + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67295", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one <=> (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654163", "l": "Activated FGFR4 binds PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28518", "l": "D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.82", "l": "\"D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56216", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71244", "l": "chloride(out) + hypotaurine(out) + 2 Na(+)(out) => chloride(in) + hypotaurine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296309", "l": "HCAR3 binds HCAR3 ligands (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15928", "l": "dihydrobunolol + NADP(+) <=> bunolol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470011", "l": "Downregulation of c-Kit signaling by SOCS6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784734", "l": "PCSK9 binds LDLR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36390", "l": "carbamoyl adenylate + kanamycin A <=> 6''-O-carbamoylkanamycin A + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683593", "l": "ATG7:ATG3:LC3 dissociates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5662466", "l": "XYLB phosphorylates D-xylulose (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19269", "l": "2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.31", "l": "\"2-furoate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.554670414377497", "identifiers": [{"i": "GO:0004714", "l": "transmembrane receptor protein tyrosine kinase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52453", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate => 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189488", "l": "UROS transforms HMB to URO3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002460", "l": "P4HB binds Collagen chains (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0034584", "l": "piRNA binding", "d": ["Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.85", "l": "\"S2P endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63801", "l": "GDP-alpha-D-mannose => GDP-beta-L-gulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210289", "l": "Recruitment of SYK to p-DAP12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44306", "l": "a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980074", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55570", "l": "2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine => 4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955844", "l": "RBKS phosphorylates ribose to R5P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49049", "l": "25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33150", "l": "ATP + daunorubicin(in) + H2O <=> ADP + daunorubicin(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44008", "l": "a 2-methyl-branched fatty aldehyde + H2O + NAD(+) = a 2-methyl fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42967", "l": "uridine(54/55) in tRNA <=> pseudouridine(54/55) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16942", "l": "N-acetylindoxyl + O2 => H2O + N-acetylisatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858482", "l": "DVL is recruited to the receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43953", "l": "3,7,11,15-tetramethylhexadecanoate + H(+) + NADPH + O2 => H2O + NADP(+) + omega-hydroxy-3,7,11,15-tetramethyl-hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2327746", "l": "FN1 aggregation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45044", "l": "2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2 = 2 Fe(III)-[cytochrome c] + H2O + nitrite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15285", "l": "AMP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.27", "l": "\"adenylate dimethylallyltransferase (AMP-dependent)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74542", "l": "creatinine(in) <=> creatinine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10247", "l": "4-fumarylacetoacetate + H2O <=> acetoacetate + fumarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59664", "l": "D-cellopentaose + O2 = D-cellopentaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26419", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 => (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19238", "l": "4-carboxymethyl-4-methylbut-2-en-1,4-olide => 4-carboxymethyl-3-methylbut-2-en-1,4-olide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16099", "l": "acetate + H(+) + pyruvate => acetylpyruvate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24160", "l": "D-galactose + O2 = D-galacto-hexodialdose + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.9", "l": "\"galactose oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024906", "l": "BDNF binds NTRK2 (TRKB) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33158", "l": "a 1-acyl-sn-glycero-3-phosphate + H2O <=> a 1-acyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76047", "l": "(S)-tetrahydropalmatine + S-adenosyl-L-methionine = (S)-cis-N-methyltetrahydropalmatine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77369", "l": "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n+1) + CMP + H(+) => [N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22477", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) => 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112121", "l": "Oxidative dealkylation of 1-etA damaged DNA By ALKBH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32290", "l": "(2R,3S)-3-isopropylmalate <=> (2S)-2-isopropylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0003943", "l": "N-acetylgalactosamine-4-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71060", "l": "L-arginine(in) + L-leucine(out) => L-arginine(out) + L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16790", "l": "a (2S)-2-hydroxycarboxylate + O2 => a 2-oxocarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797100", "l": "CCNK binds CDK13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25603", "l": "2-(2-methylsulfanyl)ethylmalate + CoA + H(+) => 4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621411", "l": "EGR2 and SREBF2(1-484) dimer bind HMGCR gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62392", "l": "levoglucosan + NAD(+) = 3-dehydrolevoglucosan + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.425", "l": "\"levoglucosan dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17362", "l": "3-oxo-3-ureidopropanoate + H2O => H(+) + malonate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008880", "l": "glucuronate isomerase activity", "d": ["Catalysis of the reaction: D-glucuronate = D-fructuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33141", "l": "L-alanine(in) + L-aspartate(out) => L-alanine(out) + L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61948", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72815", "l": "L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) = L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57544", "l": "(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": [], "t": []}, {"i": "EC:1.14.14.160", "l": "\"zealexin A1 synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66947", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32664", "l": "5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine => (3R)-5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944227", "l": "Association of procollagen type XXII (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15318", "l": "a 2-deoxy-alpha-D-glucoside + H2O => 2-deoxy-D-glucose + an alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0055055", "l": "D-glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. D-glucose is the dextrorotatory D-enantiomer of glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-217255", "l": "FMO1:FAD N-oxidises TAM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53593", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + H2O => 1-tetradecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483089", "l": "PE is converted to PS by PTDSS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72507", "l": "2-oxoglutarate(in) + prostaglandin F2alpha(out) = 2-oxoglutarate(out) + prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37174", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21756", "l": "H2O + N-deacetylisoipecoside = dopamine + secologanin", "d": [], "t": []}, {"i": "EC:4.3.3.3", "l": "\"deacetylisoipecoside synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72854", "l": "ADP(out) + AMP(in) <=> ADP(in) + AMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757578", "l": "ALB binds PREDN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36424", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008446", "l": "GDP-mannose 4,6-dehydratase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44589", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64450", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650858", "l": "Meglitinides bind ABCC8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375302", "l": "Kinetochore capture of astral microtubules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727869", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to HNRNPA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0170053", "l": "nuclease activator activity", "d": ["Binds to and increases the activity of a nuclease."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875817", "l": "MET phosphorylates STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31288", "l": "H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA => acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47097", "l": "(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate => (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11981", "l": "2 gamma-L-glutamyl-L-cysteine + NADP(+) => bis-gamma-glutamylcystine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38514", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38385", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58965", "l": "H2O + hexanal + O2 => H(+) + H2O2 + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706399", "l": "RHOBTB3 hydrolyzes ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66375", "l": "H2O + sn-glycerol 3-phosphate <=> glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38880", "l": "a fatty acid(in) => a fatty acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001081", "l": "(1->4)-beta-D-galactan binding", "d": ["Binding to (1->4)-beta-D-galactan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-874087", "l": "SGT1 binds HSP90 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57864", "l": "indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.165", "l": "\"indole-3-carbonyl nitrile 4-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53104", "l": "4-hydroxyestrone + S-adenosyl-L-methionine = 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48999", "l": "3-methylcatechol + O2 <=> 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55281", "l": "13-cis-retinol + tetradecanoyl-CoA => 13-cis-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32323", "l": "ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.86", "l": "\"ent-kaurene monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381644", "l": "ER calcium channels open in response to activated PKA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296043", "l": "Activation of HCN channels (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15675", "l": "acetoacetate + CoA + H(+) => acetoacetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047728", "l": "carnitine 3-dehydrogenase activity", "d": ["Catalysis of the reaction: carnitine + NAD+ = 3-dehydrocarnitine + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671993", "l": "CIT-3 binds DLG4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29613", "l": "H(+) + NADPH + 2 nitric oxide => H2O + NADP(+) + nitrous oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004366", "l": "glycerol-3-phosphate O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64100", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + TAN-1612", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051212", "l": "vanadium ion binding", "d": ["Binding to a vanadium ion (V)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73452", "l": "adenosine 3',5'-bisphosphate(in) + AMP(out) => adenosine 3',5'-bisphosphate(out) + AMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030378", "l": "serine racemase activity", "d": ["Catalysis of the synthesis of free D-serine from L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20315", "l": "1D-myo-inositol hexakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22121", "l": "CoA + GTP + succinate => GDP + phosphate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944454", "l": "mTORC1 phosphorylates MAF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74786", "l": "tyramine(in) <=> tyramine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62064", "l": "2-deoxy-D-glucose 6-phosphate + NAD(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37426", "l": "aclacinomycin N + O2 <=> aclacinomycin A + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32216", "l": "(6R)-NADHX => (6S)-NADHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9860273", "l": "Dimerization of p-S446-IRF5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001154", "l": "TFIIIB-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.6", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43457", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA => (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102476", "l": "pinocembrin 2-hydroxylase activity", "d": ["Catalysis of the reaction: pinocembrin + NADPH + O2 + H+ = 2,5,7-trihydroxyflavanone + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47847", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31337", "l": "diphosphate + Mo-molybdopterin cytosine dinucleotide => CTP + H(+) + Mo-molybdopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389159", "l": "CSF1R trans-autophosphorylates on multiple tyrosine and serine residues (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664850", "l": "ATM binds PEX5 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27619", "l": "(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate => di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23691", "l": "adenine + H(+) + H2O <=> hypoxanthine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110159", "l": "TDG glycosylase mediated recognition and binding of an uracil opposite to a guanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032448", "l": "DNA hairpin binding", "d": ["Binding to a DNA region containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16701", "l": "17alpha-estradiol + NAD(+) = estrone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948136", "l": "ULK1 Translocates to the mitochondria (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873917", "l": "Translocation of STAT1 dimer to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12197", "l": "keto-D-fructose 6-phosphate + phosphate => acetyl phosphate + D-erythrose 4-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140733", "l": "tRNA ligase activator activity", "d": ["Binds to and increases the activity of a tRNA ligase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9718360", "l": "GNRHR binds GNRHR peptide agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032408", "l": "MutSbeta complex binding", "d": ["Binding to a MutSbeta mismatch repair complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15780", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O <=> 1-guanidino-1-deoxy-scyllo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0035757", "l": "chemokine (C-C motif) ligand 19 binding", "d": ["Binding to chemokine (C-C motif) ligand 19."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78411", "l": "carbendazim + H2O = 2-aminobenzimidazole + CO2 + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483174", "l": "PE is methylated to PC by PEMT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932020", "l": "GPAM gene expression is stimulated by RUNX1 and ESR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67556", "l": "3'-phosphoadenylyl sulfate + glycocholate = adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686625", "l": "LAIR1 binds collagen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018794", "l": "RHOV binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59708", "l": "D-maltotriono-1,5-lactone + H2O = D-maltotrionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844415", "l": "PRDM16 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16898", "l": "a 3beta-hydroxysteroid + a triacylglycerol => a 3beta-hydroxysteroid ester + a diacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420233", "l": "VIP receptors bind VIP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37928", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32589", "l": "(3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+) => (1R,4R)-dihydrocarvone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47678", "l": "ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate => ATP + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047042", "l": "androsterone dehydrogenase (B-specific) activity", "d": ["Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0000332", "l": "template for synthesis of G-rich strand of telomere DNA activity", "d": ["Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032184", "l": "SUMO polymer binding", "d": ["Binding to a polymer of the small ubiquitin-like protein SUMO."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203700", "l": "eNOS translocation from Golgi to Caveolae (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2152276", "l": "Secretion of transmembrane collagens (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28172", "l": "butan-2-one + hydrogen cyanide => (2R)-2-hydroxy-2-methylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72740", "l": "chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) => chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19393", "l": "L-lysine + pyruvate = (S)-2-amino-6-oxohexanoate + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.71", "l": "\"lysine--pyruvate 6-transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52356", "l": "3'-phosphoadenylyl sulfate + pregnenolone = adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667563", "l": "AVPR2 bind desmopressin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41548", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.307", "l": "\"8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)-tetracenomycin-C 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871227", "l": "RET binds GFRA4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58774", "l": "1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37288", "l": "ATP + H2O + L-alanyl-L-leucine(out) => ADP + H(+) + L-alanyl-L-leucine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77148", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + H2O => 1D-myo-inositol 1,4,5-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416690", "l": "SEMA4A binds to PLXND1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74323", "l": "O-3-hydroxybutanoyl-(R)-carnitine(in) = O-3-hydroxybutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10107", "l": "2-oxoglutarate + gibberellin A20 + O2 <=> CO2 + gibberellin A1 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44816", "l": "1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-12 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23180", "l": "a secondary alcohol + O2 = a ketone + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.18", "l": "\"secondary-alcohol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58431", "l": "(E,E)-2,4-hexadien-1-ol + NADP(+) <=> (E,E)-2,4-hexadienal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29091", "l": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)", "d": [], "t": []}, {"i": "EC:7.1.1.2", "l": "\"NADH:ubiquinone reductase (H(+)-translocating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17098", "l": "3-phenylpyruvate => enol-phenylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10869", "l": "a 1,2-diacyl-sn-glycerol + an acyl-CoA => a triacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60083", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 <=> 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0046983", "l": "protein dimerization activity", "d": ["The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74804", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49787", "l": "chenodeoxycholoyl-CoA + taurine <=> CoA + H(+) + taurochenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36255", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O", "d": [], "t": []}, {"i": "EC:1.14.16.5", "l": "\"alkylglycerol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047683", "l": "aryl-aldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362427", "l": "Hh-Np binds GPC5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37540", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39069", "l": "acetyl-CoA + hexanedioyl-CoA => 3-oxooctanedioyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14767", "l": "CO2 + excited coelenteramide h monoanion + H(+) + hnu => coelenterazine h + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.27", "l": "\"D-galactarolactone cycloisomerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696547", "l": "STAMBPL1 is a deubiquitinase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34808", "l": "(R)-dihydrocamalexate + O2 + reduced [NADPH--hemoprotein reductase] => camalexin + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12103", "l": "1,5-anhydro-D-fructose <=> H2O + microthecin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28476", "l": "D-glucarate(out) + H(+)(out) => D-glucarate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34569", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH => CDP-alpha-D-paratose + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57855", "l": "a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O <=> 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74560", "l": "aldosterone => aldosterone hemiacetal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12263", "l": "ATP + NADH <=> ADP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68257", "l": "L-cystine(in) + Na(+)(in) => L-cystine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55963", "l": "4-(trimethylamino)butanoate + ATP + CoA <=> 4-(trimethylamino)butanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419841", "l": "Light stimulates opsin receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950365", "l": "Expression of S-methyl-5'-thioadenosine phosphorylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981093", "l": "IL12 bound to IL12R internalises (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.36", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726875", "l": "HCNs:cAMP bind SNIs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6804266", "l": "CHEK2 phosphorylates TTC5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61880", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.72", "l": "\"acetylxylan esterase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13519", "l": "ADP + dTDP => ATP + dTMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13383", "l": "a carboxylate + acetyl-CoA => acetate + an acyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75206", "l": "alpha,alpha-trehalose(out) + ATP + H2O <=> ADP + alpha,alpha-trehalose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47382", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-al + H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78283", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = (-)-somaliensene B + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.217", "l": "\"somaliensene B synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.7", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022911", "l": "CSPG is secreted (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10559", "l": "D-glyceraldehyde 3-phosphate + L-arginine <=> H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39750", "l": "cholesterol(in) <=> cholesterol(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71531", "l": "guanine(out) = guanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685318", "l": "BCDX2 complex formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13357", "l": "3-hydroxypropanoate + NAD(+) = 3-oxopropanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.59", "l": "\"3-hydroxypropionate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64508", "l": "acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine = 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34715", "l": "15-methylhexadecasphing-4-enine + ATP = 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445700", "l": "Myosin Binds ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725009", "l": "NPM1-ALK translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27475", "l": "ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+) => ATP + D-glycero-beta-D-manno-heptose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78718", "l": "3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + H2O <=> 3-dehydro-D-glucose + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18650", "l": "D-galactonate => 2-dehydro-3-deoxy-D-galactonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36063", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + kunzeaol", "d": [], "t": []}, {"i": "EC:4.2.3.143", "l": "\"kunzeaol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.45043725250369", "identifiers": [{"i": "GO:0030545", "l": "signaling receptor regulator activity", "d": ["Binds to and modulates the activity of a receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60216", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071576", "l": "tetrahydrodictyopterin binding", "d": ["Binding to tetrahydrodictyopterin, the pterin 2-amino-6-[(1R,2R)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5604929", "l": "Activated protein C binds Protein S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11637", "l": "NADP(+) + prostaglandin E1 => 15-oxoprostaglandin E1 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984689", "l": "Kinesin-7 is a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.674113164858127", "identifiers": [{"i": "GO:0004197", "l": "cysteine-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22436", "l": "(2E,6E)-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.22", "l": "\"germacradienol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855232", "l": "RELN:VLDLR binds DAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17564", "l": "acetylcholine + H2O <=> acetate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9842656", "l": "ALK binds ALKAL ligand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0004022", "l": "alcohol dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50920", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 = chromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044588", "l": "laminaribiose binding", "d": ["Binding to laminaribiose, a disaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225919", "l": "Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72722", "l": "eIF2 activation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18411", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH => 4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38872", "l": "uridine(2457) in 23S rRNA => pseudouridine(2457) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015636", "l": "short-chain fatty acid transmembrane transporter activity", "d": ["Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23593", "l": "glycerol + NADP(+) => D-glyceraldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641147", "l": "DACT1 binds DVL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61470", "l": "a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13145", "l": "4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate = alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine", "d": [], "t": []}, {"i": "EC:2.4.1.320", "l": "\"1,4-beta-mannosyl-N-acetylglucosamine phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022398", "l": "ACE:Zn2+ hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46477", "l": "4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666178", "l": "RTKN binds RHOA, RHOC or RHOB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753634", "l": "GGT dimers hydrolyse APAP-SG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66573", "l": "2-naphthol + 3'-phosphoadenylyl sulfate => 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60677", "l": "(S)-(-)-citronellol + NAD(+) => (S)-(-)-citronellal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49435", "l": "cholate + lithocholoyl-CoA <=> choloyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140704", "l": "3',2'-cyclic GMP-AMP binding", "d": ["Binding to 3',2' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 2',5' linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41439", "l": "(9Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (9Z-octadecenoate) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762343", "l": "PREDL:ALB dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56198", "l": "H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11878", "l": "15-oxoprostaglandin E2 + H(+) + NADH => NAD(+) + prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52451", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate <=> 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12254", "l": "(E)-coniferol + D-glucose => 4-O-(beta-D-glucosyl)-(E)-coniferol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664646", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55775", "l": "a jasmonate + an L-alpha-amino acid + ATP <=> a jasmonyl-L-amino acid + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62250", "l": "chloroacetate + 2 H(+) + NADPH => chloroacetaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159773", "l": "Furin cleaves pro-protein S to protein S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46801", "l": "H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22818", "l": "alpha-D-xylulofuranose => alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11022", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5-trisphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73101", "l": "3'-dephospho-CoA(out) + AMP(in) => 3'-dephospho-CoA(in) + AMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49341", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin => 2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45749", "l": "(3Z)-hexenoyl-CoA => (2E)-hexenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34567", "l": "CDP-alpha-D-paratose + NADP(+) = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.342", "l": "\"CDP-paratose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57780", "l": "2-chloro-4-nitrotoluene + NADH + O2 = 3-chloro-4-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592436", "l": "Initial activation of proMMP9 by MMPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009817", "l": "Acitretin binds to RAR:RXR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29568", "l": "2 chloride(in) + H(+)(out) => 2 chloride(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682026", "l": "MRN bound to shortened telomeres activates ATM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46011", "l": "CoA + NAD(+) + pentanal <=> H(+) + NADH + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688294", "l": "SIRT5 deacetylates Cytochrome C (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67966", "l": "4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine => 4-methylamino-L-phenylalanine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41185", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37627", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047342", "l": "galactose-1-phosphate thymidylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-galactose 1-phosphate + dTTP = diphosphate + dTDP-D-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52880", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52263", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide c <=> a bacteriochlorophyllide e + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168871", "l": "Fusion of vesicle containing the HA trimer, NA tetramer and M2 tetramer to the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.1", "l": "\"deoxyribonuclease I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74994", "l": "Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20004", "l": "glycolaldehyde + H2O + NAD(+) <=> glycolate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701488", "l": "Active ALK phosphorylates JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322434", "l": "XIAP dissociates from ub-TLE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811427", "l": "COPI vesicle uncoating at the ER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844440", "l": "PPARG binds EBF2-bound gene loci (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18616", "l": "4-methoxybenzoate + AH2 + O2 <=> 4-hydroxybenzoate + A + formaldehyde + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24571", "l": "a 6-phospho-beta-D-galactoside + H2O <=> an alcohol + D-galactose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30767", "l": "D-glucurono-3,6-lactone + H2O = D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437230", "l": "L1-FGFR cis-heterodimerization (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9822532", "l": "ADAMTS13 cleaves VWF multimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340226", "l": "CYGB dioxygenates NO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942302", "l": "MMP13 cleaves OPTC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429683", "l": "CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140842", "l": "n fibrin monomers -> fibrin multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606789", "l": "ARSB hydrolyses DS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66393", "l": "ATP + H2O + prostaglandin E1(in) => ADP + H(+) + phosphate + prostaglandin E1(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49986", "l": "(1R,2R)-12-hydroxyjasmonate + H2O + NADP(+) => H(+) + jasmonate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875661", "l": "GGA3 associates with activated MET receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53082", "l": "4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40491", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847968", "l": "PTEN binds FRK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14761", "l": "H(+) + hexadecanoyl-CoA + L-serine = 3-oxosphinganine + CO2 + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.50", "l": "\"serine C-palmitoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60628", "l": "AH2 + gluconapin + O2 = A + H2O + progoitrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10703", "l": "H2O + limonene 1,2-epoxide <=> limonene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77597", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-3-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990310", "l": "type-III dockerin domain binding", "d": ["Binding to a type-III dockerin domain of a protein. Type-III dockerin domain is the binding partner of type-III cohesin domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373075", "l": "Metabotropic glutamate receptors bind glutamate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56039", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53032", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 2-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9839053", "l": "AFG3L2:SPG7 binds SMDT1 (EMRE) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65925", "l": "2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine => 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47908", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O = 6-deoxy-6-sulfo-D-gluconate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.99", "l": "\"6-deoxy-6-sulfogluconolactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180855", "l": "Translocation of Vpr to the mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65510", "l": "H2O2 + NH4(+) + pre-mycofactocin => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45721", "l": "N-hexadecanoylsphing-4-enine(in) => N-hexadecanoylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76569", "l": "1,5-anhydro-D-erythro-hex-1-en-3-ulose + kermesate => 3'-dehydrocarminate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938987", "l": "BLK gene expression is stimulated by the complex of RUNX1 and ELF1, ELF2 or PAX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53861", "l": "7beta-hydroxy-3,12-dioxo-5beta-cholan-24-oate + NADP(+) => dehydrocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696356", "l": "OSCAR binds collagen and SP-D (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78988", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => cattleyene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604731", "l": "Autocatalytic activation of MMP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632668", "l": "SMO translocates to the cilium (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18461", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.67", "l": "\"1-alkylglycerophosphocholine O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70050", "l": "2-oxoadipate + L-kynurenine <=> H2O + kynurenate + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55403", "l": "7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) <=> archaeosine(15) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730886", "l": "Phosphorylation of SHC by SYK kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693575", "l": "DNA-PKcs autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031891", "l": "type 1 vasoactive intestinal polypeptide receptor binding", "d": ["Binding to a type 1 vasoactive intestinal polypeptide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2870221", "l": "E-selectin binds E-selectin ligand (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9851407", "l": "FAM83B, (FAM83A, FAM83D) bind EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785181", "l": "LMF1,2 bind LIPC dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847544", "l": "The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69351", "l": "S-1-propenyl-L-cysteine sulfoxide <=> (E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37452", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA => 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38662", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2301205", "l": "SETD8 monomethylates histone H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21709", "l": "H2O + S-adenosyl-L-homocysteine => adenosine + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000010", "l": "heptaprenyl diphosphate synthase activity", "d": ["Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878186", "l": "CDKN1A gene expression is synergistically activated by RUNX3, SMAD3 and SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047368", "l": "UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate = adenosine 3',5'-diphosphate + H+ + UDP-N-acetyl-D-galactosamine 4,6-disulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32483", "l": "H(+) + H2O + pheophorbide a = CO2 + methanol + pyropheophorbide a", "d": [], "t": []}, {"i": "EC:3.1.1.82", "l": "\"pheophorbidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.18", "l": "\"polysaccharide O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15564", "l": "S-adenosyl-L-methionine + sterigmatocystin <=> 8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29524", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64324", "l": "(11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700175", "l": "Active ALK phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69487", "l": "dodecan-1-ol + O2 <=> dodecanal + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418091", "l": "F2R binds ARRB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58903", "l": "1-carboxybiuret + H2O <=> NH4(+) + urea-1,3-dicarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928656", "l": "gamma-secretase cleaves EPHB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604368", "l": "Autocatalytic activation of bound proMMP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24876", "l": "H2O + O-phospho-D-serine <=> D-serine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31861", "l": "glutinol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866269", "l": "ARRB bind GPCRs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731141", "l": "Syndecan-1 binds fibronectin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33613", "l": "H(+) + methanol + salicylate => H2O + methyl salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29285", "l": "L-alanine(out) + Na(+)(out) => L-alanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169402", "l": "ISGylation of E2 conjugating enzymes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017447", "l": "MECP2 binds PPARG gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983518", "l": "IL35 binds IL6ST:IL6ST receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22131", "l": "(1S,2R,4S)-borneol + NAD(+) <=> (1S,4S)-camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47286", "l": "6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76362", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36414", "l": "7-dehydrocholesterol + hnu <=> calciol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14734", "l": "Ag(+)(in) + ATP + H2O => ADP + Ag(+)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.16", "l": "\"Xaa-Trp aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.12", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.15", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73043", "l": "creatine(in) = creatine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018325", "l": "ESR1:ESTG binds CXXC5 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35383", "l": "precorrin-6B + S-adenosyl-L-methionine = CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794351", "l": "SHARPIN binds SHANK proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28324", "l": "UDP + wogonin 7-O-beta-D-glucuronate => UDP-alpha-D-glucuronate + wogonin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49857", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72618", "l": "H(+)(out) + L-alanyl-L-valine(out) <=> H(+)(in) + L-alanyl-L-valine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63739", "l": "2-phenylacetaldehyde + H(+) + NADPH <=> 2-phenylethanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111264", "l": "Addition of nucleotides between position +11 and +30 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72770", "l": "acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH <=> 7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37709", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50579", "l": "acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61599", "l": "[DsbD protein]-dithiol + [thioredoxin]-disulfide <=> [DsbD protein]-disulfide + [thioredoxin]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683801", "l": "CHEK2 phosphorylates BRCA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694527", "l": "Loss of SAR1B GTPase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.10.-.-", "l": "\"Transferring molybdenum- or tungsten-containing groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57095", "l": "AH2 + S-(methylsulfanyl)glutathione <=> A + glutathione + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15032", "l": "D-mannitol + NAD(+) <=> D-mannose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39010", "l": "a cholesterol ester(in) <=> a cholesterol ester(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199203", "l": "PANK1/3 phosphorylate PanK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19506", "l": "indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose => (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102173", "l": "24-methylenecycloartanol 4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 24-methylenecycloartanol + NADH + O2 + H+ = 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193684", "l": "p62 recruits an atypical PKC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55519", "l": "11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26057", "l": "diphosphate + GDP-valienol => GTP + H(+) + valienol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65645", "l": "(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804596", "l": "APAF1:CYCS binds APIP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61539", "l": "ent-kaur-16-ene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-kaur-16-en-19-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682011", "l": "LC3 binds ATG7 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052686", "l": "perillic acid-CoA ligase (AMP-forming) activity", "d": ["Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + AMP + diphosphate + perillyl-CoA."], "t": []}, {"i": "KEGG.REACTION:R06368", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016990", "l": "arginine deiminase activity", "d": ["Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453183", "l": "p-Y348-SYK dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58851", "l": "(6E)-8-hydroxygeraniol + NAD(+) <=> (6E)-8-hydroxygeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061686", "l": "hercynylcysteine sulfoxide synthase activity", "d": ["Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (hercynine) + O2 = hercynylcysteine sulfoxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70707", "l": "6-sulfo-beta-D-quinovose = 6-sulfo-D-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050148", "l": "nucleotide diphosphokinase activity", "d": ["Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18896", "l": "a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592249", "l": "NRF1, PPRC1, NRF2 bind the TFAM promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797090", "l": "CCNK binds CDK12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16846", "l": "acetyl-CoA + H2O + oxaloacetate => citrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28463", "l": "pyridoxal(in) => pyridoxal(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44349", "l": "ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide B + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62414", "l": "acetyl-CoA + vanillin => (E)-feruloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912352", "l": "Galactosylation of Pre-NOTCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17582", "l": "an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O => an L-alpha-amino acid + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69226", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate + D-glucose + H(+) => a (Z)-alkenyl glucosinolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047005", "l": "16-alpha-hydroxysteroid dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59689", "l": "D-maltoheptaose + O2 => D-maltoheptaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27497", "l": "3'-O-methyltricetin + S-adenosyl-L-methionine = 3',5'-di-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28605", "l": "L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17010", "l": "2-succinylbenzoate + ATP + CoA => 2-succinylbenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46296", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60474", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => (6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16319", "l": "H(+) + indan-1-one + NADH => (S)-indan-1-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051786", "l": "all-trans-retinol 13,14-reductase activity", "d": ["Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964274", "l": "G alpha (12) binds BTK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56136", "l": "2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O", "d": [], "t": []}, {"i": "EC:1.11.1.7", "l": "\"peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938853", "l": "CDK6 binds RUNX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-996755", "l": "ZFPM proteins bind GATA proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696274", "l": "RND1 binds GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18192", "l": "[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61769", "l": "rebaudioside A + UDP-alpha-D-glucose => H(+) + rebaudioside D + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9858589", "l": "DLD dimer dehydrogenates dihydrolipoyl (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52724", "l": "3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate = a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.38", "l": "\"aliphatic desulfoglucosinolate sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42649", "l": "(2,5-ethylene furandicarboxylate)(n) + 2 H2O => (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10604", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}, {"i": "EC:3.1.4.3", "l": "\"phospholipase C\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9855212", "l": "SDHA binds to SDHB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70333", "l": "3-hydroxyphenylacetate + CoA + H(+) => 3-hydroxyphenylacetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190258", "l": "FGFR2c binds to FGF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39559", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA = (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9670673", "l": "FIX is secreted (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030741", "l": "inositol 1-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65503", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11204", "l": "apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin = AMP + diphosphate + H(+) + holo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": [], "t": []}, {"i": "EC:6.3.4.10", "l": "\"biotin--[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67815", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine <=> a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21025", "l": "CoA + glyoxylate + NADP(+) => H(+) + NADPH + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026579", "l": "NTRK2 phosphorylates PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40542", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19986", "l": "NAD(+) + S-(hydroxymethyl)glutathione => H(+) + NADH + S-formylglutathione", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51034", "l": "dichlorochromopyrrolate + H(+) + NH4(+) => 7-chloroindole-3-pyruvate imine dimer", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70653", "l": "H(+) + holo-[ACP] + N(6)-[(9Z)-hexadecenoyl]-L-lysyl-[protein] => (9Z)-hexadecenoyl-[ACP] + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31241", "l": "4 CO2 + coproporphyrinogen I => 4 H(+) + uroporphyrinogen I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36140", "l": "(E)-hexadec-2-enoate + ATP + CoA => (2E)-hexadecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13458", "l": "3-methyl-2-oxobutanoate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] => CO2 + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71091", "l": "dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664976", "l": "Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18649", "l": "D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20369", "l": "betaine aldehyde + H2O + O2 = glycine betaine + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102469", "l": "naringenin 2-hydroxylase activity", "d": ["Catalysis of the reaction: (S)-naringenin + NADPH + O2 = 2-hydroxynaringenin + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419083", "l": "Myosin phosphatase inactivation by ROCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853444", "l": "AURKA phosphorylates PHLDA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62117", "l": "H2O + iminosuccinate => NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44789", "l": "2-demethylmenaquinol-11 + S-adenosyl-L-methionine => H(+) + menaquinol-11 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50847", "l": "(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68914", "l": "AMP + diphosphate + NADP(+) + propanal => ATP + H(+) + NADPH + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981892", "l": "Active G alpha (z) binds RGS proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392263", "l": "AVP(20-28) binds AVPR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202168", "l": "Phosphorylation of ZAP-70 by Lck (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76967", "l": "a short-chain fatty aldehyde + H2O + NADP(+) = a short-chain fatty acid + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68152", "l": "a 1,3-diacylglycerol + a fatty acyl-CoA = a triacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75664", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate => 10,11-epoxy-12-hydroxy-(14Z)-eicosenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0005220", "l": "inositol 1,4,5-trisphosphate-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59045", "l": "dammarenediol-II + UDP-alpha-D-glucose => (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65989", "l": "previtamin D3 => calciol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13518", "l": "ATP + dTMP => ADP + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28107", "l": "galactitol 1-phosphate + NAD(+) => H(+) + keto-D-tagatose 6-phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856550", "l": "MLXIPL:MLX binds ACACA gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645598", "l": "RRAGC,D hydrolyzes GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40296", "l": "ATP + CoA + hexadecanedioate => AMP + diphosphate + hexadecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71957", "l": "glutarate(in) + 3 Na(+)(in) => glutarate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9032798", "l": "DOCK3 activates RAC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34639", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 = H2O + NADP(+) + neopentalenolactone D", "d": [], "t": []}, {"i": "EC:1.14.13.171", "l": "\"neopentalenolactone D synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.1", "l": "\"phosphodiesterase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73034", "l": "Cd(2+)(out) + H(+)(out) <=> Cd(2+)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687088", "l": "PKA phosphorylates MAPKAPK5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391935", "l": "DP1 receptor can bind PGD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429714", "l": "CSNK1G2 phosphorylates p-CERT1-2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51074", "l": "a phenol + an aryl sulfate => a phenol + an aryl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24617", "l": "17beta-estradiol + NADP(+) => estrone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140758", "l": "metal-dependent deNEDDylase activity", "d": ["An metal-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.244991688848543", "identifiers": [{"i": "GO:0099604", "l": "ligand-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74930", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + H(+) + holo-[ACP] <=> (2E)-butenoyl-[ACP] + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786650", "l": "DDHD1,2 hydrolyse PA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73664", "l": "(E,E)-piperoyl-CoA + pyrrolidine => CoA + H(+) + piperyline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70595", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12356", "l": "D-mannose 6-phosphate = D-fructose 6-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.8", "l": "\"mannose-6-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854052", "l": "Formation of the SCF-FBXL7 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35335", "l": "H(+) + isopentadecanoyl-CoA + malonyl-CoA = 3-oxoisoheptadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904408", "l": "melatonin binding", "d": ["Binding to melatonin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869580", "l": "DEK binds TFAP2A homodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637808", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65296", "l": "(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48557", "l": "4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) => 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000120", "l": "CBLIF binds RCbl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42648", "l": "(2,5-ethylene furandicarboxylate)(n) + 2 H2O = (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72245", "l": "guaiacol + H(+) + S-adenosyl-L-homocysteine => catechol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018701", "l": "2,5-dichlorohydroquinone reductive dehalogenase activity", "d": ["Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25418", "l": "(9Z)-octadecenoyl-CoA + A + 2 H2O => AH2 + O2 + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2245218", "l": "CDK1 phosphorylates PHF8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52586", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH => chenodeoxycholoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174367", "l": "GCL ligates L-Glu to L-Cys (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20815", "l": "(3S)-citryl-CoA <=> acetyl-CoA + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016913", "l": "follicle-stimulating hormone activity", "d": ["The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8983307", "l": "IL15 binds IL15RA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19578", "l": "luteolin + UDP-alpha-D-glucose => H(+) + luteolin 7-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39851", "l": "2 a 1-acyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63075", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4 CO2 + 4 CoA + orcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73806", "l": "AIR + CO2 => CAIR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32895", "l": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.56", "l": "\"1,8-cineole 2-exo-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164834", "l": "Enzyme-bound ATP is released (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13277", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate = [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.29", "l": "\"cyanophycin synthase (L-aspartate-adding)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983422", "l": "Disassembly of COPII coated vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23043", "l": "2-oxobutanoate + acetyl-CoA + H2O <=> (R)-2-ethylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102118", "l": "gibberellin A4 carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: gibberellin A4 + S-adenosyl-L-methionine = gibberellin A4 methyl ester + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13654", "l": "[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose => [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004490", "l": "methylglutaconyl-CoA hydratase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71090", "l": "17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) <=> 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3782655", "l": "HDAC10 deacetylates histone (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55964", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57209", "l": "glyoxal + L-cysteinyl-[protein] => S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65677", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontadienoyl)-sphing-4-enine => a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontadienoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193653", "l": "NGF homodimer binds to p75NTR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26504", "l": "2 H(+) + ternatin C5 + UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031299", "l": "taurine-pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36207", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44750", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) => 5-amino-1-(beta-D-ribosyl)imidazole + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13021", "l": "H(+) + NADH + O2 + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.82", "l": "\"vanillate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33091", "l": "1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37549", "l": "3-dehydro-D-glucose 6-phosphate + H(+) + NADH => D-glucose 6-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853792", "l": "RET tyrosine phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15739", "l": "5-valerolactone + H2O + NADP(+) => cyclopentanone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140482", "l": "iron sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of iron."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70481", "l": "TPI1 isomerizes GA3P to DHAP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48217", "l": "H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5604929", "l": "Activated protein C binds Protein S (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21185", "l": "a dolichyl phosphate + GDP-alpha-D-mannose => a dolichyl beta-D-mannosyl phosphate + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76944", "l": "3-aminohexane + H2O + NADP(+) => H(+) + hexan-3-one + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202328", "l": "Translocation of PKC theta to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30238", "l": "H2O + L-glutamate 5-semialdehyde + NAD(+) <=> 2 H(+) + L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445699", "l": "ATP Hydrolysis By Myosin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849908", "l": "SALM4 binds flotillin-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30114", "l": "Fe(III)-enterobactin + H(+) + 3 H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77263", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine(in) = beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983519", "l": "IL35 binds IL12RB2:IL12RB2 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602316", "l": "Defective MyD88 does not oligomerize within the complex of activated TLR5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12519", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-(R)-germacrene A + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25406", "l": "(R)-3-hydroxy-3-methyl-2-oxopentanoate => (S)-2-ethyl-2-hydroxy-3-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14696", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836275", "l": "TFAP2A binds TFAP2B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71521", "l": "uridine(in) => uridine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35913", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51828", "l": "ATP(in) + CoA(in) + docosanoate(out) + H(+)(out) = AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68960", "l": "DNA polymerase epsilon binds at the origin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76044", "l": "(S)-cis-N-methyltetrahydropalmatine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + muramine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74585", "l": "N-acetyl-L-cysteine + N-terminal L-glutamyl-[protein] => H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015546", "l": "sulfathiazole transmembrane transporter activity", "d": ["Enables the transfer of sulfathiazole from one side of a membrane to the other. Sulfathiazole is an antibacterial agent of the sulfonamide group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.n2", "l": "\"argonaute-2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984733", "l": "Kinesin-3 is a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.1", "l": "\"exodeoxyribonuclease I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51561", "l": "(S)-bulbocapnine + S-adenosyl-L-methionine => (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63230", "l": "9-O-adenylylspectinomycin + diphosphate => ATP + spectinomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.-.-", "l": "\"Catalysing the translocation carbohydrates and their derivatives\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19603", "l": "2,3,5-trihydroxytoluene + H2O + NAD(+) => H(+) + NADH + O2 + orcinol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34397", "l": "L-beta-phenylalanine => L-phenylalanine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847977", "l": "FRK phosphorylates PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36483", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69445", "l": "(2E,6E)-farnesyl diphosphate => alpha-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297333", "l": "Association of Acrosin Heavy and Light Chain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029273", "l": "PI3K binds to p-6Y-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.59", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000319", "l": "BORA binds PLK1 and AURKA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22641", "l": "NADP(+) + sphinganine => 3-oxosphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40485", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420980", "l": "Activation of Ca permeable AMPA receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42450", "l": "(2E)-glutaconyl-CoA + H2O => (R)-2-hydroxyglutaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57560", "l": "(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.161", "l": "\"nepetalactol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38608", "l": "2'-phospho-cyclic ADP-ribose + nicotinate => nicotinate-adenine dinucleotide phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004314", "l": "[acyl-carrier-protein] S-malonyltransferase activity", "d": ["Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50615", "l": "decanal + NADP(+) <=> (2E)-decenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046559", "l": "alpha-glucuronidase activity", "d": ["Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20484", "l": "3'-phosphoadenylyl sulfate + coelenterazine h <=> adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202466", "l": "Interaction of Bcl10 to CARMA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74993", "l": "deoxyerythrostominone(out) => deoxyerythrostominone(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849085", "l": "ARHGAP35 binds RHOA:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22864", "l": "L-lysine = D-lysine", "d": [], "t": []}, {"i": "EC:5.1.1.5", "l": "\"lysine racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22474", "l": "(R)-4'-phosphopantetheine + ADP + H(+) => (R)-pantetheine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610726", "l": "The IFT-A complex recruits TULP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3221982", "l": "BANP binds TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023178", "l": "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59331", "l": "D-xylono-1,5-lactone + H2O <=> D-xylonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0000701", "l": "purine-specific mismatch base pair DNA N-glycosylase activity", "d": ["Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site."], "t": []}, {"i": "EC:3.2.2.31", "l": "\"adenine glycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9718020", "l": "PTGFR binds PTGFR agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77077", "l": "Capping complex formation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60285", "l": "N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68567", "l": "6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24149", "l": "D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30933", "l": "acetate + H(+) + L,L-cystathionine => L-cysteine + O-acetyl-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636375", "l": "SecA2 transports SapM from cytoplasm to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667914", "l": "ALK binds ligand midkine (MDK) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60631", "l": "AH2 + gluconapin + O2 <=> A + H2O + progoitrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448629", "l": "IL33 binds IL1RL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47866", "l": "dioctanoylglycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707659", "l": "Hemes:LY96 activates TLR4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10075", "l": "N,N-dimethylglycine + S-adenosyl-L-methionine <=> glycine betaine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42508", "l": "6-acetamido-2-oxohexanoate + H2O + NAD(+) = 5-acetamidopentanoate + CO2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66036", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685230", "l": "CHEK1 phosphorylates RAD51 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71027", "l": "L-glutamine(in) + L-phenylalanine(out) = L-glutamine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140769", "l": "ACP-dependent peptidyl-lysine N6-myristoyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + tetradecanoyl-[ACP] = H+ + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]."], "t": []}, {"i": "RHEA:70611", "l": "L-lysyl-[protein] + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44907", "l": "alpha-D-glucose 6-phosphate + H2O <=> alpha-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39061", "l": "26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61691", "l": "ATP + holo-[peptidyl-carrier protein] + L-threonine <=> AMP + diphosphate + L-threonyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35534", "l": "cyclo(L-phenylalanyl-L-leucyl) + 2 O2 <=> albonoursin + 2 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0051117", "l": "ATPase binding", "d": ["Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70991", "l": "H(+)(in) + L-mannopyranose(in) = H(+)(out) + L-mannopyranose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38233", "l": "1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA => (9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73855", "l": "5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose = 5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14462", "l": "(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose => (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39820", "l": "docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21764", "l": "heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.18", "l": "\"heme oxygenase (biliverdin-producing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76643", "l": "xanthine(out) = xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28281", "l": "3-sulfino-L-alanine + H2O <=> H(+) + L-alanine + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51876", "l": "2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate = desmethylxanthohumol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749647", "l": "CES2 hydrolyzes ASA- (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25644", "l": "(1R,4S)-menthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13015", "l": "an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26397", "l": "all-trans-zeaxanthin + 2 O2 = 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": [], "t": []}, {"i": "EC:1.13.11.84", "l": "\"crocetin dialdehyde synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17052", "l": "3-demethylubiquinol-9 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.7.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41124", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28964", "l": "H(+)(out) + L-proline(out) => H(+)(in) + L-proline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39380", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH => (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685607", "l": "Sialic acid binds SIGLEC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50544", "l": "prostaglandin C2 = prostaglandin B2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59614", "l": "beta-alanine + L-ornithine => beta-alanyl-L-ornithine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30239", "l": "n a quinone + n H(+) + n hydrogen sulfide = n a quinol + n sulfur", "d": [], "t": []}, {"i": "EC:1.8.5.4", "l": "\"bacterial sulfide:quinone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43135", "l": "N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67285", "l": "(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione => (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66354", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH => (3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44148", "l": "L-lysine = D-beta-lysine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.37", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78461", "l": "a [peptide](in) + ADP + H(+) + phosphate => a [peptide](out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28730", "l": "Cu(2+)(in) + H(+)(in) <=> Cu(2+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75272", "l": "S-adenosyl-L-methionine + serotonin => 5-methoxytryptamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33037", "l": "2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029690", "l": "Caspase-6 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211191", "l": "Association of DFF with alpha:beta importin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093332", "l": "p-EPHB phosphorylates SDC2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624112", "l": "CEBPA binds CDK4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15529", "l": "bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.60", "l": "\"bis(2-ethylhexyl)phthalate esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046180", "l": "KSPG is secreted from the cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22592", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (9S,13S,15Z)-12-oxophyto-10-15-dienoate", "d": [], "t": []}, {"i": "EC:5.3.99.6", "l": "\"allene-oxide cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428609", "l": "Type I Na+-coupled phosphate co-transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60316", "l": "N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16113", "l": "2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) = 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.16.1.6", "l": "\"cyanocobalamin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67983", "l": "beta-zeacarotene <=> 7,8-dihydro-beta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40409", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341072", "l": "SUMOylation of RARA with SUMO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15284", "l": "lathosterol <=> 5alpha-cholest-8-en-3beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35297", "l": "AMP + H2O + W-molybdopterin cofactor => adenylyl-molybdopterin + H(+) + tungstate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38760", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047008", "l": "pregnan-21-ol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + pregnan-21-ol = H+ + NADPH + pregnan-21-al."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77382", "l": "H(+) + hnu + tetradecanoate <=> CO2 + tridecane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20005", "l": "an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate", "d": [], "t": []}, {"i": "EC:3.2.1.139", "l": "\"alpha-glucuronidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757448", "l": "ST translocates from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53688", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40640", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O => (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63822", "l": "H(+) + holo-[aryl-carrier protein] + petrobactin => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0035514", "l": "DNA demethylase activity", "d": ["Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626914", "l": "α2-agonists bind ADRA2A,B,C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420688", "l": "GABAB heterodimeric receptor binds GABA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112042", "l": "Opioid binds MOR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.15", "l": "\"aminopeptidase Y\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61940", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose = 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018503", "l": "trans-1,2-dihydrodiolphenanthrene dehydrogenase activity", "d": ["Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032557", "l": "pyrimidine ribonucleotide binding", "d": ["Binding to a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73073", "l": "genkwanin + H(+) + S-adenosyl-L-homocysteine => apigenin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26528", "l": "a (2E)-enoyl-CoA + H2O => a (3R)-3-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111238", "l": "Formation of ADAR2  homodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19232", "l": "AMP + an aromatic aldehyde + diphosphate + NADP(+) <=> an aromatic carboxylate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357432", "l": "AXL binds SRC-1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416698", "l": "SEMA5A binds to PLXNB3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62447", "l": "L-canavanine + L-ornithine <=> H(+) + L-arginine + L-canaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41283", "l": "H2O + N-tetracosanoyl-sphing-4-enine = sphing-4-enine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.-", "l": "\"Metallocarboxypeptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9859163", "l": "DBT transfers BCAA to CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29189", "l": "fumarate + ubiquinol-8 => succinate + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67866", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418866", "l": "PITPalpha binds DCC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16823", "l": "6-phospho-2-dehydro-D-gluconate + H(+) + NADH => 6-phospho-D-gluconate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72672", "l": "The 60S subunit joins the translation initiation complex  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19491", "l": "2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+) => dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55354", "l": "13-cis-retinol => all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21511", "l": "all-trans-retinyl hexadecanoate + H2O <=> H(+) + hexadecanoate + retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833063", "l": "Expression of GBX2 in posterior neural plate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10609", "l": "(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] => (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29779", "l": "ATP + H2O + L-methionine(out) = ADP + H(+) + L-methionine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32088", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate => [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32342", "l": "(+)-thujan-3-ol + NADP(+) <=> (+)-thujan-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869627", "l": "NMRK2 phosphorylates NR to yield NMN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791096", "l": "Expression of PPP2R5B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474266", "l": "Formation of collagen fibrils (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28436", "l": "((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP] => (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46581", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 => 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22738", "l": "(6R)-5,10-methenyltetrahydrofolate + NH4(+) => 5-formimidoyltetrahydrofolate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61088", "l": "(S)-eriodictyol + 2-oxoglutarate + O2 = (2R,3R)-dihydroquercetin + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10602", "l": "prostaglandin D2 => prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614271", "l": "Autocleavage of ADGRG6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57060", "l": "2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47594", "l": "a ganglioside GP1c (d18:1(4E)) + CMP + H(+) => a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981622", "l": "Myoglobin:oxygen dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707659", "l": "Hemes:LY96 activates TLR4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391934", "l": "DP2 receptor can bind PGD2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654224", "l": "Activated FGFR3 binds PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811454", "l": "MAPKs phosphorylate PP2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14773", "l": "2 NADPH + palmatine + S-adenosyl-L-methionine = corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.147", "l": "\"corydaline synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45493", "l": "phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016941", "l": "natriuretic peptide receptor activity", "d": ["Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080102", "l": "3-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 3-methylthiopropyl-glucosinolate = 3-methylsulfinylpropyl-glucosinolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40012", "l": "(+)-copalyl diphosphate + H2O => diphosphate + manool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35364", "l": "(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH => isopentadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23651", "l": "dTDP-6-deoxy-beta-L-talose + NADP(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24597", "l": "acetyl-CoA + L-histidine => CoA + H(+) + N(alpha)-acetyl-L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36881", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29327", "l": "(S)-malate(in) + succinate(out) = (S)-malate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602484", "l": "Activation of proMMP11 by FURIN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60883", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58453", "l": "N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018572", "l": "EGFR phosphorylates NOTCH3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12665", "l": "a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.81", "l": "\"aminoglycoside N(3)-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015446", "l": "ATPase-coupled arsenite transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59088", "l": "D-histidine + S-adenosyl-L-methionine = (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.5.1.152", "l": "\"D-histidine 2-aminobutanoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132136", "l": "Vitronectin binds to C5b-C7 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432129", "l": "FGR binds and phosphorylates LRP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68939", "l": "ATP + H(+) + NADPH + nonanoate <=> AMP + diphosphate + NADP(+) + nonanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59822", "l": "adenosine 3'-diphosphate,5'-triphosphate + AMP => 2 ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160154", "l": "tRNA pseudouridine(38/39) synthase activity", "d": ["Catalysis of the reaction: uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41669", "l": "dihydrochelirubine + NADP(+) => chelirubine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51318", "l": "H2O + N-(9Z-octadecenoyl)glycine => (9Z)-octadecenoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45560", "l": "L-isoleucine = D-allo-isoleucine", "d": [], "t": []}, {"i": "EC:5.1.1.21", "l": "\"isoleucine 2-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48883", "l": "a quinone + CO + H2O <=> a quinol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944219", "l": "Association of procollagen type XVI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192627", "l": "Viral mRNA Export (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202713", "l": "CD84 homodimerises (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74536", "l": "2 AH2 + 2 archaetidylglycerol + 4 S-adenosyl-L-methionine => 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether glycerophospholipid + 4 H(+) + 4 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78855", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + O2 = a medium-chain (2E)-enoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53232", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443439", "l": "c-Src binds Raf1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47630", "l": "3-methylmalate + CoA + H(+) => glyoxylate + H2O + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40750", "l": "2-oxoglutarate + L-lysine + O2 <=> (3S)-3-hydroxy-L-lysine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36566", "l": "GDP-beta-L-colitose + NADP(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446194", "l": "Addition of a third glucose to the N-glycan precursor by an ALG10 homologue (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72111", "l": "L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) = L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30627", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) = (2S)-2-acetolactate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109700", "l": "AKT2 binds PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54373", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-(2S,3R,9R)-pristinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046175", "l": "Further sulfation on galactose residues produces KSPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73534", "l": "CTP(out) + UTP(in) <=> CTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64103", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + TAN-1612", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50482", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72959", "l": "(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) = (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46967", "l": "lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49373", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate => H2O + NAD(+) + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47120", "l": "docosanoate + glycine = H2O + N-docosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21766", "l": "biliverdin IXalpha + CO + Fe(2+) + H(+) + 3 H2O + 3 oxidized [NADPH--hemoprotein reductase] => heme b + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654510", "l": "FGFRL1 binds SPRED1/2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749590", "l": "ASA- acetylates ALB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34595", "l": "H(+) + isopentadecanoyl-CoA + L-serine = 3-dehydro-15-methylhexadecasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30366", "l": "fumonisin B1 + 2 H2O <=> (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42940", "l": "cytidine(34) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(34) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61657", "l": "(2E,6E)-farnesol + ATP => (2E,6E)-farnesyl phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-573294", "l": "Activated TRAF6 synthesizes free K63 linked pUb chains. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40629", "l": "2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate => H2O + trihexadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664867", "l": "NBR1 binds MAP1LC3B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41390", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate => 1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102586", "l": "cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + 1-O-sinapoyl-beta-D-glucose = cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6'-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.74", "l": "\"deoxycytidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852324", "l": "GTSE1 binds PLK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62069", "l": "2-deoxy-D-glucose 6-phosphate + NADP(+) => 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47738", "l": "5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73874", "l": "(R)-noradrenaline(out) <=> (R)-noradrenaline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.58", "l": "\"longifolene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35587", "l": "FMN + H2O = phosphate + riboflavin", "d": [], "t": []}, {"i": "EC:3.1.3.102", "l": "\"FMN hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35512", "l": "glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] => glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928656", "l": "gamma-secretase cleaves EPHB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351901", "l": "Caspase-mediated cleavage of MST3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58838", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78606", "l": "(3S)-hydroxyoctadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41594", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13804", "l": "3 H2O + hydrogen sulfide + 3 NADP(+) <=> 4 H(+) + 3 NADPH + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74672", "l": "UDP-beta-L-arabinopyranose(in) + UMP(out) => UDP-beta-L-arabinopyranose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31076", "l": "(3S)-3-hydroxydodecanoyl-CoA => (2E)-dodecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052896", "l": "spermidine oxidase (propane-1,3-diamine-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermidine = 1,3-diaminopropane + 4-aminobutanal + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37949", "l": "12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102432", "l": "quercetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine = rhamnetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404134", "l": "RBP4:atROL binds TTR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686174", "l": "Accessory proteins are recruited to the maturing virion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004586", "l": "ornithine decarboxylase activity", "d": ["Catalysis of the reaction: L-ornithine + H+ = CO2 + putrescine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33241", "l": "aminoacetone + CO2 + NADH => L-threonine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38671", "l": "sphinganine 1-phosphate(in) = sphinganine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17777", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.47", "l": "\"1-alkyl-2-acetylglycerophosphocholine esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51371", "l": "glycine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24573", "l": "[(1->4)-alpha-D-glucosyl](n) + sucrose => [(1->4)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71697", "l": "2 H(+)(in) + L-alanyl-L-aspartate(in) => 2 H(+)(out) + L-alanyl-L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33930", "l": "4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 <=> 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30637", "l": "a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19053", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": [], "t": []}, {"i": "EC:3.5.4.27", "l": "\"methenyltetrahydromethanopterin cyclohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41477", "l": "an acyl-CoA + zymosterol => CoA + zymosterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50448", "l": "AH2 + prostaglandin G3 = A + H2O + prostaglandin H3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696564", "l": "USP25 deubiquitinates DDX58 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9704248", "l": "CHRM4 binds CHRM4 antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13241", "l": "ATP + L-fucose = ADP + beta-L-fucose 1-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.52", "l": "\"fucokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36503", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73982", "l": "(2E,6E)-farnesyl diphosphate <=> calarene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928646", "l": "EPHAs bind EFNAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004074", "l": "biliverdin reductase (NAD(P)H) activity", "d": ["Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9839368", "l": "TGFBR3(1-783) binds to TGFB1,TGFB2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71869", "l": "glycodeoxycholate(in) => glycodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39110", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183122", "l": "Factor D cleaves C3b-bound Factor B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717205", "l": "GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72803", "l": "L-arginine(out) + N(omega)-methyl-L-arginine(in) = L-arginine(in) + N(omega)-methyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418868", "l": "Recruitment of Src and Fyn to DCC:FADK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15287", "l": "diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate => AMP + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102652", "l": "gibberellin A9,2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A9 + 2-oxoglutarate + O2 = gibberellin A51 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67348", "l": "apigenin 7-O-beta-D-glucoside + malonyl-CoA = apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034823", "l": "citronellyl-CoA ligase activity", "d": ["Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205306", "l": "Interaction of SHP1 and KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10402", "l": "2-oxoglutaramate + L-alanine => L-glutamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44201", "l": "12-methyloctadecanoate + ATP + CoA => 12-methyloctadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805205", "l": "GPR35 binds kynurenic acid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340226", "l": "CYGB dioxygenates NO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71405", "l": "2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209840", "l": "Two DITs combine to form thyroxine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55141", "l": "D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] => AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15745", "l": "[(2->1)-beta-D-fructosyl](n) + sucrose = [(2->1)-beta-D-fructosyl](n+1) + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.9", "l": "\"inulosucrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835885", "l": "p-PKR dimer phosphorylates eIF2-alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5681987", "l": "LC3 is cleaved by ATG4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53326", "l": "2-glyceryl-prostaglandin E2 => 2-glyceryl-prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784765", "l": "p-Y705-STAT3 dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36829", "l": "D-glucose + diosgenin + 2 L-rhamnopyranose => dioscin + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784189", "l": "JAKs bind LIFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55685", "l": "chorismate + NH4(+) => 4-amino-4-deoxychorismate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68247", "l": "L-phenylalanine(in) + Na(+)(in) <=> L-phenylalanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159773", "l": "Furin cleaves pro-protein S to protein S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24229", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) => 4-methylcatechol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140078", "l": "class I DNA-(apurinic or apyrimidinic site) endonuclease activity", "d": ["Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51140", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 = (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57954", "l": "catechol + H2O + NAD(+) => H(+) + NADH + O2 + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46299", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019133", "l": "choline monooxygenase activity", "d": ["Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57152", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 = (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.63", "l": "\"peptidyl-lysine (3S)-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839376", "l": "TGFBR3(784-851) degradation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102212", "l": "unsaturated chondroitin disaccharide hydrolase activity", "d": ["Catalysis of the reaction: beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005078", "l": "MAP-kinase scaffold activity", "d": ["The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632672", "l": "ADRBK1 phosphorylates SMO dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77246", "l": "H(+) + hnu + octadecanoate <=> CO2 + heptadecane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950608", "l": "Expression U2 small nuclear ribonucleoprotein A' (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20939", "l": "2,3-dihydroxy-3-methylbutanoate <=> 3-methyl-2-oxobutanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44598", "l": "a fatty acid + H(+) + holo-[ACP] => a fatty acyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730842", "l": "PI3K associates with phosphorylated GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38727", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42144", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9853376", "l": "FIGNL1 binds SPIDR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714691", "l": "RAC3 binds ER effectors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43541", "l": "ATP + L-seryl-[isocitrate dehydrogenase] => ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35621", "l": "D-glucarate => L-idarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5263633", "l": "DYSF, CAV3 and TRIM72 bind (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72366", "l": "chloride(out) + hydrogencarbonate(in) <=> chloride(in) + hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23122", "l": "a dipeptide(in) + ADP + H(+) + phosphate => a dipeptide(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28861", "l": "Ag(+)(out) + H(+)(out) => Ag(+)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842833", "l": "SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15758", "l": "L-homoserine + NAD(+) => H(+) + L-aspartate 4-semialdehyde + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40164", "l": "D-glyceraldehyde + H2O + NADP(+) => (R)-glycerate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49527", "l": "2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 <=> a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943279", "l": "GGT dimers hydrolyse GSH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071987", "l": "WD40-repeat domain binding", "d": ["Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9858752", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114684", "l": "Phosphorylation of Syntaxin-4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56248", "l": "1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55712", "l": "3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030750", "l": "putrescine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67031", "l": "(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O <=> (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444691", "l": "Prokineticin receptors bind prokineticin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72634", "l": "Ca(2+)(in) + 3 Li(+)(out) <=> Ca(2+)(out) + 3 Li(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005047", "l": "signal recognition particle binding", "d": ["Binding to a signal recognition particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019137", "l": "thioglucosidase activity", "d": ["Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57009", "l": "5,5'-dehydrodivanillate + H(+) + NADH + O2 => 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002440", "l": "Removal of fibrillar collagen C-propeptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32896", "l": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] => 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51663", "l": "an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 <=> an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202604", "l": "Formation of a heteromeric BMP receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42914", "l": "5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30561", "l": "guanosine + H(+) + triphosphate => GTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.923250621671642", "identifiers": [{"i": "GO:0008188", "l": "neuropeptide receptor activity", "d": ["Combining with a neuropeptide to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807826", "l": "LDHAL6B reduces PYR to LACT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57343", "l": "3-hydroxy-L-kynurenine + S-adenosyl-L-methionine <=> 3-hydroxy-4-methyl-L-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41877", "l": "(3R)-hydroxydodecanoyl-[ACP] => (2E)-dodecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9828175", "l": "Formation of the NSL complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25253", "l": "ATP + N-acetyl-D-mannosamine = ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48704", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34747", "l": "15-methylhexadecasphinganine + ATP = 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854303", "l": "TBC1D11 binds RAB6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612671", "l": "ERBB4 gene expression is stimulated by ERBB4s80:ESR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25246", "l": "(R)-S-lactoylglutathione + H2O => (R)-lactate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22772", "l": "L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.68", "l": "\"L-fuconate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35700", "l": "(S)-versiconol + NADP(+) => (2S-3S)-versiconal hemiacetal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74042", "l": "D-alanine(out) + L-alanine(in) <=> D-alanine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21013", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75043", "l": "L-cystine(out) + L-leucine(in) = L-cystine(in) + L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210274", "l": "SIRP beta binds TYROBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619376", "l": "CAMK1 binds calmodulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45123", "l": "(4R)-ipsdienol + NAD(+) <=> H(+) + ipsdienone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033837", "l": "anthocyanin 3'-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59263", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047613", "l": "aconitate decarboxylase activity", "d": ["Catalysis of the reaction: cis-aconitate + H+ = CO2 + itaconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046659", "l": "digestive hormone activity", "d": ["The action characteristic of a hormone that takes part in the digestion process."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74711", "l": "Phosphorylation of IRS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29422", "l": "H(+)(out) + Na(+)(in) <=> H(+)(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381545", "l": "Formation of the IGF:IGFBP5:ALS complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686088", "l": "CASP3 cleaves GSDMD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15969", "l": "2 glutathione + H(+) + methylarsonate = glutathione disulfide + H2O + methylarsonous acid", "d": [], "t": []}, {"i": "EC:1.20.4.2", "l": "\"methylarsonate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003680", "l": "minor groove of adenine-thymine-rich DNA binding", "d": ["Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420202", "l": "Secretin receptor binds secretin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.18", "l": "\"calcidiol 1-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660479", "l": "MTF1 dimer:12Zn2+ binds SNCB gene (beta-synuclein) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179413", "l": "Activated PKC-alpha  activate MMP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1370500", "l": "PRLR binds SCF beta-TrCP complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-481009", "l": "Exocytosis of platelet dense granule content (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40742", "l": "(20S)-ginsenoside Rb2 + 2 H2O <=> (20S)-ginsenoside C-Y + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848339", "l": "PNPLA5 hydrolyzes TAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730868", "l": "Phosphorylation of MEK7 by MEKK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10949", "l": "ATP + D-glucosamine => ADP + D-glucosamine 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805638", "l": "KAT6A acetylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1964496", "l": "STING binds TRIM32 or TRIM56  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44489", "l": "3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046934", "l": "1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351207", "l": "Spermine  => N-acetylated spermine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33790", "l": "3'-ketolactose + H2O <=> 3-keto-beta-D-galactose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.12", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34913", "l": "D-methionine(out) => D-methionine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24577", "l": "diphosphate + H2O => H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76186", "l": "2 H(+)(out) + L-alanyl-L-alanine(out) <=> 2 H(+)(in) + L-alanyl-L-alanine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9709098", "l": "DHFR dimer reduces FOLA to DHF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37210", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51312", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.62", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987223", "l": "IL10RB binds TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0032037", "l": "myosin I heavy chain binding", "d": ["Binding to a heavy chain of a myosin I complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74984", "l": "(3R)-3-isocyanylbutanoyl-AMP + holo-[ACP] => (3R)-3-isocyanylbutanoyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54139", "l": "cytidine(48) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679239", "l": "ULK complex translocates to the ER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187632", "l": "arginine + H2O => ornithine + urea (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73805", "l": "diphosphate + isoechinulin B => dimethylallyl diphosphate + neoechinulin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0043998", "l": "histone H2A acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047920", "l": "geissoschizine dehydrogenase activity", "d": ["Catalysis of the reaction: geissoschizine + NADP+ = 4,21-dehydrogeissoschizine + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60830", "l": "a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate => a 5'-end triphospho-adenosine in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10156", "l": "dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.101", "l": "\"dihydrochelirubine 12-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33465", "l": "5-dehydroepisterol + 2 H2O + NADP(+) => episterol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24249", "l": "glyoxylate + L-alanine => glycine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69937", "l": "guanosine(in) + Na(+)(in) => guanosine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46624", "l": "a D-5-monosubstituted hydantoin = a L-5-monosubstituted hydantoin", "d": [], "t": []}, {"i": "EC:5.1.99.5", "l": "\"hydantoin racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13696", "l": "(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047868", "l": "dimethylmaleate hydratase activity", "d": ["Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60232", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62096", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102773", "l": "dihydroceramide kinase activity", "d": ["Catalysis of the reaction: ATP + a dihydroceramide = ADP + H+ + a dihydroceramide 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44786", "l": "H(+) + menaquinol-10 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-10 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41634", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47394", "l": "an aliphatic alcohol + H(+) + hexadecanoate => H2O + hexadecanoate ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53371", "l": "5,6-dihydrouridine(17) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(17) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44915", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH <=> (3E)-hexenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40612", "l": "H2O + trihexanoylglycerol => 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39701", "l": "(2E,13Z)-eicosadienoyl-CoA + H2O => (R)-3-hydroxy-(13Z)-eicosenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645481", "l": "TIFA oligomerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25267", "l": "2-phenylacetaldehyde + H2O2 + NH4(+) => 2-phenylethylamine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0052664", "l": "nitroalkane oxidase activity", "d": ["Catalysis of the reaction: nitroalkane + H2O + O2 = an aldehyde or ketone + nitrite + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852200", "l": "Inactivation of LCK by PTPN22 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9846305", "l": "ST6GALNAC5,6 transfer Neu5Ac to GM1b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63113", "l": "A + ascofuranol => AH2 + ascofuranone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0051903", "l": "S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activity", "d": ["Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5323526", "l": "FRAT proteins bind GSK3beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58543", "l": "2 L-ascorbate + N-dodecanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19931", "l": "[(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611751", "l": "β1,2-agonists bind ADRB1,2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432897", "l": "ILK interacts with beta-1 integrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77538", "l": "H2O + L-methionyl-tRNA(Leu) <=> H(+) + L-methionine + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72526", "l": "1,6-dihydroxyphenazine + S-adenosyl-L-methionine <=> 1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016711", "l": "flavonoid 3'-monooxygenase activity", "d": ["Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417842", "l": "P2Y10 receptor can bind to LPA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577259", "l": "MSH2 variant:MSH3-defective DNA mismatch repair (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66711", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430135", "l": "p-SLP-76 binds ADAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938487", "l": "miR-20a binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16795", "l": "(R)-4'-phosphopantetheine + CO2 => H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54053", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + tau-cadinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088134", "l": "PLK1 phosphorylates FOXM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42251", "l": "butanoyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxohexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050044", "l": "galactose-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-606287", "l": "RSF complex binds the centromere (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44674", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507719", "l": "p62:MEKK3 binds to TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990650", "l": "inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015575", "l": "mannitol transmembrane transporter activity", "d": ["Enables the transfer of mannitol from one side of a membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070737", "l": "protein-glycine ligase activity, elongating", "d": ["Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53723", "l": "ATP + N-acetyl-D-muramate <=> ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69518", "l": "H2O2 + N-acetyl-D-galactosamino-1,5-lactone => N-acetyl-D-galactosamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481009", "l": "Exocytosis of platelet dense granule content (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51986", "l": "all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71551", "l": "5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16633", "l": "guanosine(34) in tRNA + queuine = guanine + queuosine(34) in tRNA", "d": [], "t": []}, {"i": "EC:2.4.2.64", "l": "\"tRNA-guanosine(34) queuine transglycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209244", "l": "REL binds to DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709360", "l": "H2O2 reduces MetHb (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60558", "l": "pseudouridine(35) in tRNA(Tyr) => uridine(35) in tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938382", "l": "LGALS3 gene expression is stimulated by RUNX1 and RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417908", "l": "P2RY1 binds ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161293", "l": "Tropoelastin forms aggregate globules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201717", "l": "CSNK2-mediated phosphorylation of DVL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39948", "l": "a 1,3-diacyl-sn-glycerol + H2O => a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26024", "l": "8'-apo-beta-carotenol + O2 => (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835328", "l": "NPM binds PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42027", "l": "3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) <=> 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44583", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) <=> 2-all-trans-decaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110307", "l": "REV1 binds AP-dsDNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45922", "l": "4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264622", "l": "Cho is acetylated to AcCho by CHAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76193", "l": "carnosine(in) + 2 H(+)(in) => carnosine(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15746", "l": "[(2->1)-beta-D-fructosyl](n) + sucrose => [(2->1)-beta-D-fructosyl](n+1) + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28696", "l": "hydrogencarbonate(in) => hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45266", "l": "(9Z,12Z)-octadecadienoate(in) => (9Z,12Z)-octadecadienoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833777", "l": "PKR binds activating host RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39627", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA = (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156682", "l": "PLK1 phosphorylates NUDC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37741", "l": "1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23844", "l": "ATP + sedoheptulose = ADP + D-sedoheptulose 7-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.14", "l": "\"sedoheptulokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179410", "l": "Association of Nek2A with MCC:APC/C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008849", "l": "enterochelin esterase activity", "d": ["Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33705", "l": "CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine => (4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031709", "l": "gastrin-releasing peptide receptor binding", "d": ["Binding to a gastrin-releasing peptide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36326", "l": "(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH <=> (9Z)-octadecen-1-ol + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004821", "l": "histidine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.140", "l": "\"gluconate/galactonate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836467", "l": "F protein binds NCL on host cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44243", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + di-(9Z)-octadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15255", "l": "CO2 + itaconate => cis-aconitate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33561", "l": "a 2-acyl-sn-glycerol 3-phosphate + CoA => an acyl-CoA + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64368", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617643", "l": "HOXA3 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0016673", "l": "oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."], "t": []}, {"i": "EC:1.8.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72209", "l": "chloride(in) + 2 hydrogencarbonate(out) => chloride(out) + 2 hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602454", "l": "proMMP9 binds TIMP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17185", "l": "IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.7.1.7", "l": "\"GMP reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57602", "l": "a 1-[(17Z)-hexacos-17-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-hexacosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2399913", "l": "atRAL binds to RBP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22739", "l": "5-formimidoyltetrahydrofolate + 2 H(+) <=> (6R)-5,10-methenyltetrahydrofolate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514790", "l": "Elastin degradation by MMP14 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-178208", "l": "SMAD7 binds to SMURF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951676", "l": "RUNX3 binds TEADs and YAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16905", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65819", "l": "AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O <=> A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204549", "l": "Caveolin-1 binds Basigin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48053", "l": "n 3'-phosphoadenylyl sulfate + dermatan => n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-936563", "l": "ISGylation of DDX58 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56264", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33636", "l": "ATP + CoA + docosanoate => AMP + diphosphate + docosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12098", "l": "benzylamine + formate => H2O + N-benzylformamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76337", "l": "L-aspartate(out) + L-tryptophan(in) => L-aspartate(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169719", "l": "Secreted CD14 binds LPS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41241", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine => N-[omega-(9Z,12Z)-octadecadienoyloxy]-acylsphin-4-enine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40214", "l": "(3S)-hydroxytetradecanedioyl-CoA + NAD(+) <=> 3-oxotetradecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120204", "l": "methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity", "d": ["Catalysis of the reaction: methylcytosine + L-ascorbate + O2 = 5-glyceryl-methylcytosine + glyoxylate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66888", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707586", "l": "FeHM oxidises LDL,HDL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50994", "l": "thromboxane B2(in) => thromboxane B2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17078", "l": "H2O + N,N-dimethylglycine + O2 => formaldehyde + H2O2 + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444661", "l": "HCAR2 binds HCAR2 ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042164", "l": "interleukin-12 alpha subunit binding", "d": ["Binding to the alpha subunit of interleukin-12."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70437", "l": "a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193668", "l": "p75NTR and RHOA-GDI interact (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798748", "l": "Exocytosis of secretory granule lumen proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190790", "l": "Assembly of gap junction plaques (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008960", "l": "phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity", "d": ["Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46652", "l": "epitestosterone + H(+) + NADPH = 5beta-dihydroepitestosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75415", "l": "H2O + N-methylmyosmine = pseudooxynicotine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027531", "l": "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0070576", "l": "vitamin D 24-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-24 of any form of vitamin D."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65956", "l": "ATP + estrone 3-sulfate(out) + H2O = ADP + estrone 3-sulfate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51457", "l": "H2O + N-(9Z-octadecenoyl)-L-isoleucine => (9Z)-octadecenoate + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66496", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72538", "l": "H2O + NADP(+) + vanillin <=> 2 H(+) + NADPH + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199144", "l": "Nectin 2 binds CD226 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15559", "l": "ADP + H(+) + Ni(2+)(in) + phosphate => ATP + H2O + Ni(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62038", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62998", "l": "(8Z,11Z,14Z)-eicosatrienoate + NH4(+) => (8Z,11Z,14Z)-eicosatrienamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74330", "l": "O-propanoyl-(R)-carnitine(in) <=> O-propanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48834", "l": "15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20955", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73980", "l": "(2E,6E)-farnesyl diphosphate => calarene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60741", "l": "(S)-(-)-citronellal + H2O + NADP(+) => (S)-(-)-citronellate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009817", "l": "Acitretin binds to RAR:RXR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58833", "l": "24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10832", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.50", "l": "\"glycosylphosphatidylinositol phospholipase D\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3965450", "l": "DAAM1 recruits PFN1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350578", "l": "NQO1 interaction with ODC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39146", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) <=> 3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429767", "l": "Passive I- efflux mediated by SLC5A8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10144", "l": "a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.6", "l": "\"3'-nucleotidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6794346", "l": "NRXNs bind NLGNs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75040", "l": "acetyl-CoA(in) => acetyl-CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801675", "l": "PLK2 phosphorylates NPM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928646", "l": "EPHAs bind EFNAs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170978", "l": "p-FRS2:CRKL binds C3G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.23", "l": "\"2-hydroxypropyl-CoM lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25466", "l": "diphosphate + longifolene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68762", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine => 3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753634", "l": "GGT dimers hydrolyse APAP-SG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390595", "l": "Calcium Binds Troponin-C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66194", "l": "(4Z,15Z)-bilirubin IXalpha C8,C12-beta-D-bisglucuronoside(out) + ADP + H(+) + phosphate => (4Z,15Z)-bilirubin IXalpha C8,C12-beta-D-bisglucuronoside(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34096", "l": "carboxyspermidine + H(+) => CO2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22770", "l": "4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one => 4-nitrophenyl-3-ketovalidamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047199", "l": "phosphatidylcholine-dolichol O-acyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + dolichol = 1-acyl-sn-glycero-3-phosphocholine + acyldolichol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61684", "l": "glycero-2-phosphocholine + H2O = glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19932", "l": "[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76458", "l": "(E)-coniferol + A <=> (E)-coniferaldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030753", "l": "8-hydroxyfuranocoumarin 8-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0015179", "l": "L-amino acid transmembrane transporter activity", "d": ["Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids."], "t": []}, {"i": "REACT:R-HSA-212614", "l": "Glutamine transport from astrocytes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29870", "l": "AMP + ITP <=> ADP + IDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18602", "l": "3,4-dihydroxyphthalate + H(+) => 3,4-dihydroxybenzoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43303", "l": "a neolactoside IV(3)-alpha-NeuGc-nLc4Cer + UDP-N-acetyl-alpha-D-galactosamine <=> a neolactoside IV(4)-beta-GalNAc-IV(3)-alpha-NeuGc-nLc4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71258", "l": "3 Na(+)(out) + phosphate(out) <=> 3 Na(+)(in) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034009", "l": "isoprene synthase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate = diphosphate + isoprene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20925", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine => a [peptide]-C-terminal amide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018423", "l": "protein C-terminal leucine carboxyl O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + [protein]-L-leucine = S-adenosyl-L-homocysteine + [protein]-L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.-.-.-", "l": "\"Isomerases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9707683", "l": "PGRMC2 binds Hemes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22676", "l": "chlorophyllide a + H(+) + NADPH + O2 = 7(1)-hydroxychlorophyllide a + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59127", "l": "(S)-2,3-diaminopropanoate + ATP + citrate <=> 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202947", "l": "Caspase mediated cleavage of APC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627107", "l": "XIAP binds CASP7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67813", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine => a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15807", "l": "(4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate => (7R,8S)-7,8-diammoniononanoate + ATP + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39757", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53443", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11238", "l": "propane-1,3-diamine + sym-homospermidine => putrescine + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22771", "l": "4-nitrophenyl-3-ketovalidamine <=> 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25501", "l": "(2E)-geranyl diphosphate => diphosphate + terpinolene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0002948", "l": "archaeosine synthase activity", "d": ["Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69005", "l": "3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite => AMP + cremeomycin + diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64101", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + TAN-1612", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55000", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0030599", "l": "pectinesterase activity", "d": ["Catalysis of the reaction: pectin + n H2O = n methanol + pectate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12993", "l": "cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.10", "l": "\"cyclohex-1-ene-1-carbonyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65390", "l": "a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050103", "l": "dextrin dextranase activity", "d": ["Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388503", "l": "Oxytocin receptor bind oxytocin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791064", "l": "Expression of ARFGAP1 (GAP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29199", "l": "(S)-dihydroorotate + menaquinone-8 = menaquinol-8 + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73752", "l": "(R)-adrenaline(in) + 2 H(+)(out) => (R)-adrenaline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25721", "l": "(E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-trihomomethionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60073", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 => 4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48855", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 <=> 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45425", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430308", "l": "PARVB interacts with Alpha-actinin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9823932", "l": "Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22914", "l": "3-methyl-2-oxobutanoate + L-alanine => L-valine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159566", "l": "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010898", "l": "ROBO2 binds SLIT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71111", "l": "L-phenylalanine(out) + S-methylmercury-L-cysteine(in) = L-phenylalanine(in) + S-methylmercury-L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55028", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine = an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033412", "l": "UAG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37802", "l": "2 H(+) + 2 NADH + O2 <=> 2 H2O + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58575", "l": "O-acetyl-15alpha-stemmadenine + O2 <=> H2O2 + precondylocarpine acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71732", "l": "citrate(out) + tartrate(in) => citrate(in) + tartrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43270", "l": "a ganglioside GM2 + H(+) + UDP => a ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901691", "l": "proton binding", "d": ["Binding to proton."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.87", "l": "\"3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674018", "l": "BRAP binds RAS:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18843", "l": "2-hydroxy-3-oxopropanoate + H(+) + NADPH => (R)-glycerate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25164", "l": "A + butanoyl-CoA = (2E)-butenoyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732527", "l": "FFAR1 binds rosiglitazone (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11293", "l": "2 H(+) + O2 + rifamycin B => H2O2 + rifamycin O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955844", "l": "RBKS phosphorylates ribose to R5P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61440", "l": "acetyl-CoA + S-(2-succino)-L-cysteine = CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10539", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O <=> 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62402", "l": "(S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1R,2S)-ephedrine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70774", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351208", "l": "Spermidine  => N-acetylated spermidine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0047225", "l": "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45410", "l": "dodecanoyl-CoA + NAD(+) => (2E)-dodecenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44447", "l": "a 1,2-diacylglycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62493", "l": "ATP + holo-[peptidyl-carrier protein] + L-arginine => AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.97", "l": "\"assemblin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20096", "l": "an anthocyanidin + H(+) + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62049", "l": "an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022881", "l": "protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70505", "l": "H(+) + isopentenyl phosphate + phosphate => H2O + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71902", "l": "3',5'-cyclic GMP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203553", "l": "eNOS binds NOSIP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75387", "l": "H2O + queuosine 5'-phosphate = D-ribose 5-phosphate + queuine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.02616462956729", "identifiers": [{"i": "GO:0038024", "l": "cargo receptor activity", "d": ["Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44213", "l": "3-hydroxytetradecanoate + ATP + CoA => 3-hydroxytetradecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67964", "l": "4-methylamino-L-phenylalanine + S-adenosyl-L-methionine = 4-dimethylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832951", "l": "Expression of ZIC2 in anterior neural plate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53155", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66821", "l": "ATP + H2O + Mn(2+)(in) => ADP + H(+) + Mn(2+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22355", "l": "H(+) + L-lysine <=> cadaverine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672159", "l": "STAT binds to p-11Y PDGFRA extracellular domain dimers  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853405", "l": "TPX2 binds AURKA at centrosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44136", "l": "dodecanoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl dodecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30487", "l": "H(+) + N,N-dihydroxy-L-isoleucine = (1E,2S)-2-methylbutanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549129", "l": "OCT1 transports organic cations into hepatic cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69823", "l": "(22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] = (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662986", "l": "MT2A binds copper (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47646", "l": "4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57072", "l": "3-oxoisoapionate 4-phosphate + H(+) = CO2 + L-erythrulose 1-phosphate", "d": [], "t": []}, {"i": "EC:4.1.1.121", "l": "\"3-oxoisoapionate-4-phosphate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41879", "l": "(3R)-hydroxydodecanoyl-[ACP] <=> (2E)-dodecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004671", "l": "protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836500", "l": "IKK complex is activated by PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029454", "l": "Autophosphorylation of PAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71407", "l": "7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] = 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48398", "l": "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine => (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983077", "l": "STAT3 binds TSLP:IL7R:CRLF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32198", "l": "abieta-7,13-dien-18,18-diol <=> abieta-7,13-dien-18-al + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012542", "l": "IL37 binds 2x(CASP1(120-197):CASP1(317-404)) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59449", "l": "dodecan-1-ol + NADP(+) => dodecanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797090", "l": "CCNK binds CDK12 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28292", "l": "(5S,9S,10S)-drim-7-en-11-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63478", "l": "15-oxoprostaglandin E2 + H(+) + NADPH => NADP(+) + prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.4", "l": "\"uracil/thymine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36921", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA => (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5213464", "l": "RIPK1 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44415", "l": "3-demethylubiquinol-10 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51625", "l": "formate + GTP + H(+) => CO2 + dGTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139905", "l": "Translocation of activated BAD protein to mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72207", "l": "chloride(out) + 2 hydrogencarbonate(in) = chloride(in) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35558", "l": "cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672978", "l": "RAF phosphorylates MAP2K dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71274", "l": "H(+)(in) + thiamine(out) <=> H(+)(out) + thiamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24800", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O <=> (S)-2-amino-6-oxoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56558", "l": "delta-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853429", "l": "PHLDA1 binds AURKA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47909", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O => 6-deoxy-6-sulfo-D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010435", "l": "3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity", "d": ["Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid + coenzyme A = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoyl-CoA + H+. 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid is also known as OPC-8:0."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166726", "l": "Activation of MASPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869543", "l": "TFPA2A homodimer and NPM1 bind the NOP2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173680", "l": "Activation of C5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46752", "l": "7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333678", "l": "CPNEs bind PL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950387", "l": "CANX binds EBI3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168046", "l": "Collagen type XII degradation by MMP12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000103", "l": "CUBN:AMN binds CBLIF:RCbl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018654", "l": "2-hydroxy-phenylacetate hydroxylase activity", "d": ["Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018699", "l": "1,1,1-trichloroethane reductive dehalogenase activity", "d": ["Catalysis of the reaction: 1,1,1-trichloroethane + 2 H+ + 2 e- = 1,1-dichloroethane + HCl."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11677", "l": "D-ribose + H2O + NADP(+) => D-ribonate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624953", "l": "ARL13B binds INPP5E (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788622", "l": "p-Y-STATs dimerize (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55745", "l": "coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64475", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine <=> (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68319", "l": "1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O <=> 1D-myo-inositol 2,4,5-triphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28145", "l": "H2O + streptothricin D <=> streptothricin D acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018766", "l": "RHOU binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56090", "l": "a globoside DSGG + CMP + H(+) => a globoside MSGG + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44634", "l": "2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA + H(+) => (3,5-dihydroxyphenyl)acetyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56228", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36753", "l": "beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-184269", "l": "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015182", "l": "L-asparagine transmembrane transporter activity", "d": ["Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047040", "l": "pteridine reductase activity", "d": ["Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + 2 NADP+ = biopterin + 2 H+ + 2 NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429992", "l": "PARN deadenylates mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31972", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + NADPH + O2 => 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17464", "l": "D-sedoheptulose 1,7-bisphosphate + H2O <=> D-sedoheptulose 7-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009936", "l": "RNASEL cleaves cellular ssRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15999", "l": "2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+) => anthraniloyl-CoA + 2 H(+) + 2 NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56616", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene = 1,2,4-trichlorobenzene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67793", "l": "ribonucleotidyl-uridine-RNA => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24728", "l": "H(+) + indolmycin + S-adenosyl-L-homocysteine => N-demethylindolmycin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29495", "l": "(2E,6E)-farnesyl diphosphate + H2O = beta-eudesmol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.68", "l": "\"beta-eudesmol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102951", "l": "indole-3-acetyl-phenylalanine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-phenylalanine + ATP = H+ + indole-3-acetyl-phenylalanine + AMP + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16805", "l": "2-oxoglutarate + deacetoxycephalosporin C + O2 = CO2 + deacetylcephalosporin C + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.26", "l": "\"deacetoxycephalosporin-C hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78784", "l": "luteolin + UDP-alpha-D-glucose => H(+) + isoorientin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12137", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) => a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007522", "l": "E2F6 binds APAF1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31568", "l": "bisphenol A + H(+) + NADH + O2 => 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696813", "l": "TSEN complex cleaves the intron from pre-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10180", "l": "(6R)-10-formyltetrahydrofolate + H2O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.6", "l": "\"formyltetrahydrofolate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019809", "l": "spermidine binding", "d": ["Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71765", "l": "2-oxoglutarate(in) + citrate(out) => 2-oxoglutarate(out) + citrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209224", "l": "SLMB binds to and ubiquitinates phosphorylated CI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836702", "l": "PKR inhibitors bind PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57631", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate <=> H2O + ML-236C carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57928", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate", "d": [], "t": []}, {"i": "EC:6.3.5.13", "l": "\"lipid II isoglutaminyl synthase (glutamine-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009541", "l": "ESR1 binds to TFF1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72840", "l": "ADP(out) + CoA(in) => ADP(in) + CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71752", "l": "2-oxoglutarate(out) + glutarate(in) => 2-oxoglutarate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227863", "l": "Recruitment of IRF to activated TBK1/IKK epsilon (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58818", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate => ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20407", "l": "(2S,6S)-2,6-diaminoheptanedioate + acetate => H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016316", "l": "phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193703", "l": "IKKbeta is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990932", "l": "5.8S rRNA binding", "d": ["Binding to 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46205", "l": "androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] => androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.-", "l": "\"Other carbon-carbon lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9008822", "l": "PPM1D dephosphorylates RUNX2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981093", "l": "IL12 bound to IL12R internalises (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12354", "l": "H2O2 + L-xylo-hex-3-ulonolactone => L-gulono-1,4-lactone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40265", "l": "3-oxohexadecanedioyl-CoA + H(+) + NADH => (3R)-hydroxyhexadecanedioyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626228", "l": "The distal appendage proteins recruit TTBK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63185", "l": "NADH + 2 O2 => H(+) + NAD(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60563", "l": "L-methionyl-[protein] + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851142", "l": "TYK2-dependent STAT1 and STAT3 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794357", "l": "SHANK proteins bind GKAPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.69", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.3.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13600", "l": "1,4-diguanidinobutane + H2O <=> agmatine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182990", "l": "Sprouty sequesters CBL away from active EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43497", "l": "L-gulonate + NAD(+) => H(+) + keto-D-fructuronate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.338568301456235", "identifiers": [{"i": "GO:0030246", "l": "carbohydrate binding", "d": ["Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74629", "l": "acetaldehyde + fumagillin + H2O + NADP(+) => NADPH + 2 O2 + prefumagillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102277", "l": "2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose exo-beta-D-glucosaminidase activity", "d": ["Catalysis of the reaction: beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O = D-glucosamine + N-acetyl-D-glucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45696", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(in) = N-(acetyl)-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68039", "l": "(S)-cystathionine ketimine + 2 H(+) + NADPH <=> (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163798", "l": "Furin cleaves pro-protein Z to protein Z (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25567", "l": "H2O + N-acetyl-4-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018774", "l": "RHOBTB1 binds GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015255", "l": "propanediol channel activity", "d": ["Enables the energy-independent facilitated diffusion of propanediol through a transmembrane aqueous pore or channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102826", "l": "kaempferol-3-glucoside-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol 3-O-glucoside = kaempferol 3,7-O-diglucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433418", "l": "Phosphorylation of JAK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31004", "l": "(S)-2,3-epoxysqualene => germanicol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008761", "l": "UDP-N-acetylglucosamine 2-epimerase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9834807", "l": "ILF3 binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71304", "l": "chloride(out) + L-methionine(out) + 2 Na(+)(out) => chloride(in) + L-methionine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134954", "l": "DHX9 binds DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168637", "l": "CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873917", "l": "Translocation of STAT1 dimer to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56217", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14174", "l": "dimethylallyl diphosphate + L-tryptophan => 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68687", "l": "3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate) <=> adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50431", "l": "methanethiol + S-adenosyl-L-methionine <=> dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9825783", "l": "p-S207 KARS1 dimer translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34174", "l": "L-aspartate 4-semialdehyde + pyruvate <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9859163", "l": "DBT transfers BCAA to CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34471", "l": "NAD(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.95", "l": "\"acryloyl-CoA reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396007", "l": "IRF3 is phosphorylated by TBK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55686", "l": "4-amino-4-deoxychorismate + H2O => chorismate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140867", "l": "NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the glutamate-18 residue of histone H2B (or an equivalent residue)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50630", "l": "a 3-(omega-methylsulfanyl)alkylmalate => a 2-(omega-methylsulfanyl)alkylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59815", "l": "hexadecanoyl-CoA + N-terminal glycyl-[protein] <=> CoA + H(+) + N-terminal N(6)-hexadecanoylglycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71046", "l": "L-alanine(in) + L-phenylalanine(out) <=> L-alanine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57323", "l": "acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43511", "l": "2,5-diformylfuran + H2O <=> 2-(dihydroxymethyl)-5-formylfuran", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11533", "l": "glycine + H2O + O2 => glyoxylate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21232", "l": "L-histidine = NH4(+) + trans-urocanate", "d": [], "t": []}, {"i": "EC:4.3.1.3", "l": "\"histidine ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046180", "l": "KSPG is secreted from the cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011748", "l": "IL9R binds JAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9837978", "l": "LONP1 binds mitochondrial inner membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062064", "l": "box C/D methylation guide snoRNP complex binding", "d": ["Binding to a box C/D methylation guide snoRNP complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398184", "l": "LARG activation by G alpha 12/13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41677", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + ATP => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75640", "l": "(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (12S,13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55308", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64729", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63824", "l": "2 3-(4-hydroxyphenyl)pyruvate = aspulvinone E + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53574", "l": "20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22298", "l": "(1R,2R,3R)-prephytoene diphosphate + diphosphate => 2 (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797974", "l": "LRRTMs bind NRXNs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41626", "l": "H(+) + propanoyl-CoA + sulfite => 3-sulfinopropanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47044", "l": "3-dehydrocarnitine + acetyl-CoA = acetoacetate + N,N,N-trimethylglycyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10495", "l": "H2O + phosphocholine <=> choline + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835252", "l": "Expression of PAX7 in the neural plate border (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047470", "l": "(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity", "d": ["Catalysis of the reaction: 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-alpha-D-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucopyranoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69493", "l": "O2 + octan-1-ol => H2O2 + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58490", "l": "H2O + NAD(+) + succinate semialdehyde + trimethylamine => 4-(trimethylamino)butanoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140844", "l": "NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the glutamate-2 residue of the N-terminal tail of histone H2B (or an equivalent residue)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047581", "l": "4-methyleneglutamate-ammonia ligase activity", "d": ["Catalysis of the reaction: 4-methylene-L-glutamate + ATP + NH4 = 4-methylene-L-glutamine + AMP + diphosphate + 2 H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.9", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52641", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA => (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52761", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O => (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39723", "l": "a 1,2-diacyl-sn-glycerol(in) = a 1,2-diacyl-sn-glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51532", "l": "H(+) + NADPH + O2 + urate = 5-hydroxyisourate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874162", "l": "ATF6B:HSPA5 (ATF6-beta:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769347", "l": "Activated glucocorticoid receptor binds NPAS4 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46204", "l": "androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] = androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.114", "l": "\"equine arterivirus serine peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13875", "l": "abieta-7,13-diene + diphosphate => (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49446", "l": "(2-aminobenzoyl)acetate + CoA + H(+) => (2-aminobenzoyl)acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57413", "l": "AMP + diphosphate + L-tyrosinal + NADP(+) => ATP + H(+) + L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45705", "l": "(E)-sinapyl alcohol + NADP(+) => (E)-sinapaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685604", "l": "SLAMF6 binds SLAMF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201521", "l": "ALK autophosphorylation  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28072", "l": "diphosphate + Fe(II)-heme o => (2E,6E)-farnesyl diphosphate + H2O + heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10263", "l": "ATP + H2O + Mg(2+)(out) <=> ADP + H(+) + Mg(2+)(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12730", "l": "lutein => (3R,3'S)-zeaxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45287", "l": "eicosanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-eicosanoyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603784", "l": "PEX19:class I PMP binds PEX3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71515", "l": "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888589", "l": "Release of GABA at the synapse (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050303", "l": "lysine 6-dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52634", "l": "[amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018454", "l": "acetoacetyl-CoA reductase activity", "d": ["Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28503", "l": "NAD(+) + S-(hydroxymethyl)mycothiol => H(+) + NADH + S-formylmycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11744", "l": "H2O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate", "d": [], "t": []}, {"i": "EC:3.6.1.28", "l": "\"thiamine-triphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34030", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5660980", "l": "p-S276-RELA binds RELB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44174", "l": "2 H(+) + NADH + tetradecanoate => H2O + NAD(+) + tetradecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48326", "l": "a ganglioside Fuc-GD1b + GDP + H(+) => a ganglioside GD1b + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120283", "l": "protein serine/threonine kinase binding", "d": ["Binding to a protein serine/threonine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047589", "l": "5-aminovalerate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49436", "l": "cholate + deoxycholoyl-CoA = choloyl-CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937177", "l": "AHR:TCDD binds ARNT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62855", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209358", "l": "Phosphorylated AP-1, Phospho JRA:Phospho KAY binds to a target gene and activates transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671772", "l": "p-T38-PPP1R14A binds MLCP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29543", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.256", "l": "\"dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050395", "l": "vitexin beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-glucose + vitexin = H+ + UDP + vitexin 2''-O-beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139899", "l": "Sequestration of BAD protein by 14-3-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26376", "l": "[thioredoxin]-disulfide + prostamide F2alpha <=> [thioredoxin]-dithiol + prostamide H2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48148", "l": "ganglioside GT1b (d18:1(4E)/18:0) + H2O = ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39137", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O2 => (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026366", "l": "NTF3-bound NTRK2 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39582", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA <=> (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2219524", "l": "PDPK1 binds PIP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62014", "l": "5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23920", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.58", "l": "\"caspase-5\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58445", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030370", "l": "intercellular adhesion molecule-3 receptor binding", "d": ["Binding to a receptor for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839734", "l": "AXIN mutants destabilize the destruction complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30092", "l": "a ubiquinone + D-alanine + H2O => a ubiquinol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940561", "l": "MMP7 cleaves OPTC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666008", "l": "SCAI binds SRF:MKL1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46129", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351948", "l": "Mitochondrial recruitment of Drp1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22705", "l": "2 H2O + ricinine => 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67758", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9859163", "l": "DBT transfers BCAA to CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38089", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35745", "l": "2 H2O + NADP(+) + versicolorin A => H(+) + NADPH + O2 + versicolorin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018667", "l": "cyclohexanone monooxygenase activity", "d": ["Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.12", "l": "\"Xaa-Xaa-Pro tripeptidyl-peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62077", "l": "D-galactose 6-phosphate + NAD(+) => 6-phospho-D-galactono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68358", "l": "L-glutamate + N-acetyl-L-aspartate => H2O + N-acetyl-L-aspartyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28718", "l": "(R)-malate(in) + 2 H(+)(in) <=> (R)-malate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55123", "l": "4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3857336", "l": "CEBPB homodimerization (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78933", "l": "a long-chain (2E)-enoyl-CoA + H2O => a long-chain (3R)-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1566962", "l": "Elastin degradation by elastin-degrading extracellular proteinases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69032", "l": "N,N-dihydroxy-L-aspartate = (2S)-2-nitrosobutanedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25478", "l": "alpha-himachalene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21662", "l": "benzoate + 2 H(+) + NADPH => benzaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871227", "l": "RET binds GFRA4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59638", "l": "D-xylotriono-1,5-lactone + H2O2 => D-xylotriose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668735", "l": "RAC1:GTP binds NOX3 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797553", "l": "Protein 4.1 binds CASK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120226", "l": "succinyl-CoA binding", "d": ["Binding to succinyl-CoA, an omega-carboxyacyl-CoA having succinoyl as the S-acyl component."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53702", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63585", "l": "2-deoxyecdysone 22-phosphate + H2O => 2-deoxyecdysone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54041", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (3E,7E)-dolathalia-3,7,11-triene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40620", "l": "H2O + tridodecanoylglycerol => 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17648", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] <=> N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008914", "l": "leucyl-tRNA--protein transferase activity", "d": ["Catalysis of the reaction: L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H+ + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu). Can also transfer the leucyl residue on an N-terminal L-lysyl residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33017", "l": "[(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+) => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42205", "l": "corticosterone + NAD(+) => 11-dehydrocorticosterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12275", "l": "H(+) + L-dopa <=> CO2 + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69549", "l": "H(+) + O-phospho-L-serine => CO2 + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2172678", "l": "PHF8 demethylates histone H4K20me1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75532", "l": "AH2 + N-acetyl-S-hydroxy-L-cysteine => A + H2O + N-acetyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18237", "l": "2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.4", "l": "\"gentisate 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64123", "l": "an N-(fatty acyl)-L-serine + H2O <=> a fatty acid + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602454", "l": "proMMP9 binds TIMP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39402", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA <=> (2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0018822", "l": "nitrile hydratase activity", "d": ["Catalysis of the reaction: an aliphatic amide = a nitrile + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0061595", "l": "6-deoxy-6-sulfofructose-1-phosphate aldolase activity", "d": ["Catalysis of the reaction 6-deoxy-6-sulfofructose-1-phosphate = 3-sulfolactaldehyde + dihydroxyacetone phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2467775", "l": "Autocleavage of ESPL1 (Separase) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047357", "l": "UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + UDP-D-galactose = H+ + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60363", "l": "FMN + H(+) + oxidized coenzyme F420-0 <=> dehydro coenzyme F420-0 + FMNH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75037", "l": "1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46003", "l": "adenosine + H(+) + tuberculosinyl diphosphate <=> 1-tuberculosinyladenosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44430", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047443", "l": "4-hydroxy-4-methyl-2-oxoglutarate aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41028", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39693", "l": "(11Z)-octadecenoyl-CoA + NADP(+) => (2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60446", "l": "an S-substituted L-cysteine + glycine => an S-substituted L-cysteinylglycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796061", "l": "NFE2L2 dependent ATF4 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40099", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130706", "l": "MHC class II antigen processing (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30852", "l": "beta-D-fructose 1-phosphate => D-glyceraldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710106", "l": "ELANE cleaves GSDMD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42630", "l": "5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(747) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66489", "l": "quillate + UDP-alpha-D-glucose => quillaic acid 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77736", "l": "2 H2O + ITP => 2 H(+) + IMP + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332235", "l": "CBL binds TGFBR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67255", "l": "H2O + malonaldehyde + NAD(+) <=> 3-oxopropanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33495", "l": "all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate = 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.n9", "l": "\"heptaprenylglyceryl phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013006", "l": "RHOA:GTP translocates to the ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76335", "l": "L-aspartate(in) + L-tryptophan(out) = L-aspartate(out) + L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793975", "l": "Expression of GATA3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72020", "l": "2-oxoglutarate + H(+) + O2 + trihazone A => 2 CO2 + H2O + succinate + trihazone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109701", "l": "PDPK1 binds PIP3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21244", "l": "an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine = an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102697", "l": "trans-zeatin-O-glucoside UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + O-beta-D-glucosyl-trans-zeatin = H+ + trans-zeatin-O-glucoside-7-N-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62095", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015374", "l": "neutral, basic amino acid:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36745", "l": "CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + tetracosenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.1.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609310", "l": "β-blockers bind ADRB1,2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018804", "l": "RAC3 GEFs activate RAC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78698", "l": "a ganglioside GA2 + UDP-alpha-D-galactose <=> a ganglioside GA1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804762", "l": "TP53 forms homotetramers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42120", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21365", "l": "H2O + N-(6-aminohexanoyl)-6-aminohexanoate => 2 6-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56670", "l": "7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10413", "l": "ADP-D-ribose + H2O => AMP + D-ribose 5-phosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193669", "l": "TRAF6 binds to p75NTR:NRIF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47404", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014296", "l": "RAC2 GEFs activate RAC2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180007", "l": "RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 5) + H2O = RNA polymerase II large subunit + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49304", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40089", "l": "22-oxodocosanoate + H(+) + NADH => 22-hydroxydocosanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59183", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O <=> 2 AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74715", "l": "Autophosphorylation of insulin receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617182", "l": "PRKACA phosphorylates PLN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16239", "l": "[protein]-peptidylproline (omega=0) => [protein]-peptidylproline (omega=180)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717841", "l": "holo-FDPS dimer binds NBPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75182", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (R)-axinyssene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46845", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73120", "l": "kaempferol + S-adenosyl-L-methionine => H(+) + kaempferol 7-methyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70501", "l": "D-galactose(in) + 2 Na(+)(in) => D-galactose(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76913", "l": "3-methylcyclohexanone + H(+) + NADH + NH4(+) => (1S)-3-methyl-cyclohexylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30635", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.267", "l": "\"dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68908", "l": "ATP + H(+) + NADPH + picolinate = AMP + diphosphate + NADP(+) + picolinal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3785711", "l": "Telomere shortening during replicative exhaustion (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388560", "l": "EDNRA,EDNRB bind EDNs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016205", "l": "selenocysteine methyltransferase activity", "d": ["Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54524", "l": "acetoacetate + H(+) + methylglyoxal = 3-hydroxyhexane-2,5-dione + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.47", "l": "\"N-acylsphingosine galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848110", "l": "SOCS3 binds activated PTK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11852", "l": "phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203862", "l": "Dicer cleaves pre-miRNA to yield duplex miRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20881", "l": "10-hydroxydecanoate + NAD(+) => 10-oxodecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139905", "l": "Translocation of activated BAD protein to mitochondria (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139906", "l": "Activation of BAD by calcineurin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252133", "l": "ATP6AP1 binds V-ATPase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11914", "l": "15-oxoprostaglandin E2 + H(+) + NADPH => 13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39596", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH => (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71780", "l": "4-methyl-2-oxopentanoate(out) + H(+)(out) => 4-methyl-2-oxopentanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27468", "l": "ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) <=> ADP-D-glycero-beta-D-manno-heptose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10519", "l": "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) <=> (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199079", "l": "Epithelial cadherin binds to KLRG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75246", "l": "acetyl-CoA + N-terminal L-leucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-leucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102099", "l": "FAD-dependent urate hydroxylase activity", "d": ["Catalysis of the reaction: 7,9-dihydro-1H-purine-2,6,8(3H)-trione + NADH + H+ + O2 = 5-hydroxyisouric acid + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67235", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+) <=> (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015416", "l": "ABC-type phosphonate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694551", "l": "3CLp cleaves nsp6-11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-741411", "l": "CYLD deubiquitinates NEMO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20929", "l": "[DsbA protein]-dithiol + a quinone => [DsbA protein]-disulfide + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710306", "l": "GSDME expression mediated by TP53, TP63 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875531", "l": "MET binds TNS4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72105", "l": "Na(+)(in) + O-propanoyl-(R)-carnitine(in) => Na(+)(out) + O-propanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034320", "l": "alcohol O-hexanoyltransferase activity", "d": ["Catalysis of the reaction: hexanoyl-CoA + an alcohol = CoA + a hexyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76408", "l": "H2O + Xaa-L-Pro dipeptide => an L-alpha-amino acid + L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229343", "l": "AXIN is phosphorylated in the destruction complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9824999", "l": "GSK3B phosphorylates p-S73 MITF-M at residue S69 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70596", "l": "GOT2 dimer deaminates L-Asp (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.6", "l": "\"aminopeptidase B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18023", "l": "a ganglioside GD1a (d18:1(4E)) + CMP + H(+) => a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66700", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0042826", "l": "histone deacetylase binding", "d": ["Binding to histone deacetylase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013159", "l": "CDC42 GEFs activate CDC42 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2691211", "l": "NOTCH1 HD domain mutants bind DLL4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690785", "l": "BAP1 binds Ub-HCFC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45138", "l": "7,8-dihydroneopterin 3'-phosphate + H2O => 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20597", "l": "2 L-cysteine + NAD(+) = H(+) + L-cystine + NADH", "d": [], "t": []}, {"i": "EC:1.8.1.6", "l": "\"cystine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31273", "l": "CO2 + H2O + NAD(+) + naphthalene-1,2-diol => 1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140439", "l": "protein-cysteine S-stearoyltransferase activity", "d": ["Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein]."], "t": []}, {"i": "RHEA:59740", "l": "L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S-octadecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61463", "l": "a cytidine in RNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75249", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-prolyl-[protein] => acetyl-CoA + N-terminal L-prolyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27446", "l": "NADP(+) + xylitol => D-xylose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707505", "l": "Hemes bind to CLEC1B dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22715", "l": "adenosylcob(III)inamide phosphate + GTP + H(+) <=> adenosylcob(III)inamide-GDP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28030", "l": "[thioredoxin]-disulfide + dGDP + H2O = [thioredoxin]-dithiol + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53422", "l": "H(+) + roseoflavin + S-adenosyl-L-homocysteine => 8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42175", "l": "(11Z)-eicosenoyl-CoA + AH2 + O2 <=> (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27850", "l": "glycine + phenylacetyl-CoA = CoA + H(+) + phenylacetylglycine", "d": [], "t": []}, {"i": "EC:2.3.1.192", "l": "\"glycine N-phenylacetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3076905", "l": "Extracellular BTD hydrolyses BCTN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22517", "l": "ATP + taurocyamine => ADP + H(+) + N-phosphotaurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102510", "l": "pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose = anthocyanidin 3,5-di-O-beta-D-glucoside + vanillate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21277", "l": "D-arabinitol + NADP(+) => D-xylulose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57471", "l": "(E)-ferulate + UDP-alpha-D-glucose <=> 1-O-[(E)-feruloyl]-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848395", "l": "IL18:IL18R1 binds IL18RAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784204", "l": "JAKs bind OSMR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70675", "l": "H2O + Met-enkephalin-Arg-Phe = L-arginyl-L-phenylalanine + Met-enkephalin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56313", "l": "3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O => 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1671687", "l": "PRLR activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35455", "l": "5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 = (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59077", "l": "bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22588", "l": "4-aminobutanal = 1-pyrroline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696356", "l": "OSCAR binds collagen and SP-D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38369", "l": "18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA => 8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71675", "l": "glycyl-L-leucine(out) + H(+)(out) = glycyl-L-leucine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48380", "l": "alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose = a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051738", "l": "xanthophyll binding", "d": ["Binding to xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26309", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.28", "l": "\"1,4-dihydroxy-2-naphthoyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16259", "l": "alpha-D-glucose + alpha-D-glucose 1-phosphate => alpha,alpha-trehalose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43237", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O => 1,2-dihexadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75170", "l": "CTP + NAD(+) <=> CDP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702818", "l": "CALCR binds erenumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12296", "l": "H2O + N-deacetylipecoside = dopamine + secologanin", "d": [], "t": []}, {"i": "EC:4.3.3.4", "l": "\"deacetylipecoside synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42253", "l": "H(+) + malonyl-[ACP] + pentanoyl-CoA => 3-oxoheptanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987039", "l": "JAK1 binds IL20RA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69829", "l": "(22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53237", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] => (24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196026", "l": "Dab2 is recruited to the junctional plaques (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53954", "l": "4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate => 4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624800", "l": "CDK1 phosphorylates LBR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41195", "l": "1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47811", "l": "epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23600", "l": "2-oxoglutarate + L-2-aminohexanoate = 2-oxohexanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.67", "l": "\"2-aminohexanoate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211874", "l": "CYP2S1 4-hydroxylates atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37606", "l": "(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74733", "l": "Insulin receptor de-phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70396", "l": "3-oxosphinganine + docosanoyl-CoA => CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018640", "l": "dibenzothiophene monooxygenase activity", "d": ["Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47074", "l": "eicosanoate + glycerol + H(+) => 1-eicosanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18992", "l": "H(+) + L-valine <=> 2-methylpropan-1-amine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59760", "l": "apigenin + UDP-alpha-D-glucose = apigenin 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852317", "l": "PLK1 phosphorylates GTSE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68611", "l": "Formation of ORC(1-5) complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051719", "l": "DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821486", "l": "HCFC1 binds SET1A complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57086", "l": "a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981931", "l": "RAC1 and CDC42 activate PAK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59005", "l": "dodecanal + H2O + O2 => dodecanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9690493", "l": "RHOB binds effectors on endosomes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693722", "l": "Unknown sepiapterin synthase transforms PTHP to sepiapterin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78928", "l": "a very-long-chain (3S)-hydroxyacyl-CoA + NAD(+) => a very-long-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40848", "l": "eicosanoyl-CoA + FAD + H(+) => (2E)-eicosenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34076", "l": "an acyl phosphate + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051700", "l": "fructosyl-amino acid oxidase activity", "d": ["Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156930", "l": "GTP-binding activates eEF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63628", "l": "ATP + hexadecanoate + holo-[ACP] = AMP + diphosphate + hexadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25482", "l": "acetoacetyl-CoA + succinate => acetoacetate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692738", "l": "HRH2 binds HRH2 antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046817", "l": "chemokine receptor antagonist activity", "d": ["Interacts with chemokine receptors to reduce the action of a chemokine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60939", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an (omega-1)-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52241", "l": "2 H2O + 2 Mn(2+) + O2 => 4 H(+) + 2 MnO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.244991688848543", "identifiers": [{"i": "GO:0043495", "l": "protein-membrane adaptor activity", "d": ["The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20966", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate => 2-oxoglutarate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18929", "l": "AH2 + O2 + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.35", "l": "\"thiophene-2-carbonyl-CoA monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140825", "l": "lactoperoxidase activity", "d": ["Catalysis of the reaction: 2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43499", "l": "L-gulonate + NAD(+) <=> H(+) + keto-D-fructuronate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0004348", "l": "glucosylceramidase activity", "d": ["Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37513", "l": "1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9856502", "l": "mito-STARD7 transports Q10 to outer mitochondrial membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209925", "l": "DIT and MIT combine to form triiodothyronine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.83", "l": "\"4-hydroxyphenylacetate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13539", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+) => (2R)-3-phosphoglycerate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32257", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+) => meso-2,6-diaminoheptanedioate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72337", "l": "3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55370", "l": "(3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine => (R)-carnitine + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375160", "l": "NCAM1 binds to ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13900", "l": "chorismate <=> prephenate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-447226", "l": "Interleukin-12 binds Interleukin-12 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28069", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) <=> alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696183", "l": "AOC3 deaminates BZAM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65027", "l": "7alpha-hydroxy-3,12-dioxo-5beta-cholanate + NADP(+) <=> dehydrocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975874", "l": "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022378", "l": "ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72620", "l": "2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848776", "l": "PTK6 phosphorylates DOK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38056", "l": "CTP + phytol => CDP + H(+) + phytyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299359", "l": "Activation of TALK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5099899", "l": "WNT5A binds FZD4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50376", "l": "a ceramide(in) + ATP + H2O = a ceramide(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37248", "l": "H2O + thymidine 3'-phosphate => phosphate + thymidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61729", "l": "a 3-dehydro-D-guloside => a 3-dehydro-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74657", "l": "H(+) + IDP + N-acetyl-D-glucosamine 6-phosphate => ITP + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62993", "l": "H2O + tetradecamide => NH4(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51013", "l": "a monoacyl-sn-glycero-3-phosphocholine + H2O => a monoacylglycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165195", "l": "GTP loading by Rheb (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44716", "l": "A + all-trans-4,4'-diapolycopen-4-al + H2O = AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875816", "l": "STAT3 binds activated MET receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58265", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21996", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.125", "l": "\"1-alkyl-2-acetylglycerol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72309", "l": "L-glutamate(out) + taurocholate(in) => L-glutamate(in) + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9773218", "l": "CDH19 associates with catenins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47828", "l": "a ganglioside GT1b + H2O = a ganglioside GD1b + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607002", "l": "Activated protein C cleaves factor VIIIa (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010473", "l": "GDP-galactose:myoinositol-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: GDP-L-galactose + myo-inositol 1-phosphate = alpha-L-galactose-1-phosphate + GDP-myoinositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22936", "l": "H2O + N-acetyl-D-glucosamine 6-phosphate = acetate + D-glucosamine 6-phosphate", "d": [], "t": []}, {"i": "EC:3.5.1.25", "l": "\"N-acetylglucosamine-6-phosphate deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18329", "l": "(1S,3R,5S)-sabinol + NAD(+) = (1S,5S)-sabinone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.228", "l": "\"(+)-sabinol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52999", "l": "[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH <=> [eIF5A protein]-deoxyhypusine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60271", "l": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53308", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036370", "l": "D-alanyl carrier activity", "d": ["Binding a D-alanine and presenting it for processing or offloading to a cognate enzyme. Covalently binds the D-alanine via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The carrier protein provides an essential link between the D-alanine-D-alanyl carrier protein ligase and the incorporation of D-alanine into lipoteichoic acid by transferring activated D-alanine to cell membrane phosphatidylglycerol (PG)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75862", "l": "Fall Back to Closed Pre-initiation Complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61951", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43966", "l": "1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48718", "l": "13-oxo-(9Z,11E)-octadecadienoate + H2O => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47517", "l": "3-oxochenodeoxycholate + H(+) + NADH => isochenodeoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50381", "l": "3 H(+) + 3 malonyl-CoA => 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844818", "l": "ELOVL3 gene expression is stimulated by EBF2 and negatively regulated by ZNF423 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47208", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50946", "l": "(E)-cinnamate + H(+) + NADH => 3-phenylpropanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66383", "l": "ATP + glutathione(in) + glycodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41276", "l": "H2O + N-eicosanoyl-sphing-4-enine => eicosanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31719", "l": "11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416698", "l": "SEMA5A binds to PLXNB3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044583", "l": "cellotriose binding", "d": ["Binding to cellotriose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120023", "l": "somatostatin binding", "d": ["Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45221", "l": "coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein] => Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21792", "l": "NADP(+) + propan-2-ol = acetone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.80", "l": "\"isopropanol dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68941", "l": "Na(+)(in) + tellurite(in) => Na(+)(out) + tellurite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28334", "l": "dATP + H2O = dAMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052796", "l": "exo-alpha-(2->8)-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51273", "l": "(9Z)-octadecenoyl-CoA + glycine => CoA + H(+) + N-(9Z-octadecenoyl)glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18899", "l": "AH2 + L-thyroxine => 3,3',5'-triiodo-L-thyronine + A + H(+) + iodide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832845", "l": "Expression of ZEB2 in neural plate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007816", "l": "RUNX2 binds HAND2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41394", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+) => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050238", "l": "pyridoxine 5-dehydrogenase activity", "d": ["Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59344", "l": "D-maltose + O2 = D-maltobiono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47371", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose <=> a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69815", "l": "cathasterone + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32360", "l": "1D-myo-inositol 1,4,5-trisphosphate + 2 ATP => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451474", "l": "Bacterial Flagellin binds TLR5 homodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49906", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2 => (1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32574", "l": "(E)-2-methylgeranyl diphosphate + H2O <=> 2-methylisoborneol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951727", "l": "cAMP binds PKA tetramer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.244991688848543", "identifiers": [{"i": "GO:0032394", "l": "MHC class Ib receptor activity", "d": ["Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17181", "l": "a long-chain fatty aldehyde + FMNH2 + O2 = a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu", "d": [], "t": []}, {"i": "EC:1.14.14.3", "l": "\"bacterial luciferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76339", "l": "2 Na(+)(out) + urate(out) = 2 Na(+)(in) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004161", "l": "dimethylallyltranstransferase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191636", "l": "Phosphorylation of Cx43 by c-src (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717202", "l": "GNAT3 exchanges GDP for GTP in L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047090", "l": "benzoyl-CoA 3-monooxygenase activity", "d": ["Catalysis of the reaction: benzoyl-CoA + H+ + NADPH + O2 = 3-hydroxybenzoyl-CoA + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420202", "l": "Secretin receptor binds secretin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692749", "l": "CDC14A,B bind MAPK6 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48323", "l": "a ganglioside GA1 + GDP-beta-L-fucose <=> a ganglioside Fuc-GA1 + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61423", "l": "(S)-8-oxocitronellyl enol <=> cis-cis-nepetalactol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34894", "l": "selenite(in) <=> selenite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18396", "l": "(R)-3-amino-2-methylpropanoate + pyruvate <=> 2-methyl-3-oxopropanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852317", "l": "PLK1 phosphorylates GTSE1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40740", "l": "(20S)-ginsenoside Rb2 + 2 H2O => (20S)-ginsenoside C-Y + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17496", "l": "A + glycerol <=> AH2 + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10983", "l": "L-serine <=> D-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047233", "l": "N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71660", "l": "a D-glucoside + 2 Fe(III)-[cytochrome c] => a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047884", "l": "FAD diphosphatase activity", "d": ["Catalysis of the reaction: FAD + H2O = AMP + FMN."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56321", "l": "a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose => an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54177", "l": "a long-chain fatty aldehyde + holo-[ACP] + NADP(+) => a long-chain fatty acyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71931", "l": "fumarate(out) + 3 Na(+)(out) = fumarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134962", "l": "DHX36 binds DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072587", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity", "d": ["Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8979071", "l": "KDM6B binds iron (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57921", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) => H(+) + L-asparaginyl-tRNA(Asn) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858346", "l": "AMHR2 binds AMH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031812", "l": "P2Y1 nucleotide receptor binding", "d": ["Binding to a P2Y1 nucleotide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37268", "l": "H2O + L-alanyl-L-aspartate => L-alanine + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691335", "l": "nsp7 binds nsp8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009541", "l": "ESR1 binds to TFF1 gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031710", "l": "neuromedin B receptor binding", "d": ["Binding to a neuromedin B receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13695", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+) => (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28455", "l": "N(6)-(D-fructosyl)-L-lysine(in) => N(6)-(D-fructosyl)-L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874849", "l": "CREBRF binds CREB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0070746", "l": "interleukin-35 binding", "d": ["Binding to interleukin-35."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44246", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41256", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69232", "l": "(Z)-3-hydroxypropyl glucosinolate + H2O = (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61249", "l": "H2O + L-tyrosine + O2 => 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45918", "l": "4-hydroxy-6-(13-hydroxy-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-hydroxyoctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28530", "l": "H2O + XMP = phosphate + xanthosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141175", "l": "receptor clustering activity", "d": ["A protein-protein adaptor that acts as a platform for receptor clustering, often serving to amplify the sensitivity of a signaling response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11692", "l": "NAD(+) + NADPH = NADH + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11275", "l": "a (2R)-2-hydroxycarboxylate + a quinone <=> a 2-oxocarboxylate + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169827", "l": "DPDK1 phosphorylates and activates DS6K (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59552", "l": "N,N',N'',N'''-tetraacetylchitotetraose + O2 = H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64234", "l": "atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O => 8 H(+) + holo-[ACP] + 8 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0016208", "l": "AMP binding", "d": ["Binding to AMP, adenosine monophosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37461", "l": "1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP => 1D-myo-inositol hexakisphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58710", "l": "rifampicin para-naphthoquinone carboxamide => rifampicin ortho-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29938", "l": "cytosine(in) + H(+)(in) <=> cytosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13406", "l": "4-coumaroyl-CoA + agmatine => CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938217", "l": "RUNX1 binds the SWI/SNF complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55607", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70522", "l": "(R)-octopamine + S-adenosyl-L-methionine <=> (R)-synephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36072", "l": "6-tuliposide A => D-glucose + tulipalin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37939", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.3.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50274", "l": "resolvin E1 => (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157926", "l": "NICD1 traffics to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41925", "l": "(3R)-hydroxyoctadecanoyl-[ACP] => (2E)-octadecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750226", "l": "NLRC5 binds IKBKB and CHUK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796045", "l": "NFE2L2 dependent TXN expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13589", "l": "3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.4.1.4", "l": "\"methylcrotonoyl-CoA carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22598", "l": "acetate + deacetylcephalosporin C + H(+) => cephalosporin C + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.36", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694733", "l": "Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428752", "l": "Dissociation of the TP:Gq complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-593685", "l": "Netrin-4 binds DCC/UNC5A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013024", "l": "RHOB binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14119", "l": "[(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102293", "l": "pheophytinase b activity", "d": ["Catalysis of the reaction: pheophytin b + H2O = H+ + pheophorbide b + phytol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.73", "l": "\"licheninase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33260", "l": "4-aminoimidazole + H(+) + 2 H2O => N-formimidoylglycine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75511", "l": "acetyl-CoA + S-benzyl-L-cysteine = CoA + H(+) + N-acetyl-S-benzyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49625", "l": "ATP + erythritol => ADP + D-erythritol 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351894", "l": "Caspase mediated cleavage of BAP31 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69015", "l": "5beta-dihydrotestosterone + H(+) + NADPH <=> 5beta-androstane-3beta,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161733", "l": "PGD2 is dehydrated to PGJ2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034321", "l": "alcohol O-octanoyltransferase activity", "d": ["Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47363", "l": "decanoate ester + H2O <=> an aliphatic alcohol + decanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62245", "l": "a cytidine(6-4)thymidine in DNA => a cytidine-thymine dinucleotide in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57189", "l": "H2O + N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] => glycolate + H(+) + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635839", "l": "ULK3:SUFU dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52302", "l": "(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24928", "l": "H2O + L-cystine => NH4(+) + pyruvate + S-sulfanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005121", "l": "Toll binding", "d": ["Binding to a Toll protein, a transmembrane receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21570", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose => beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727607", "l": "MME:Zn2+ binds sacubitrilat (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032810", "l": "sterol response element binding", "d": ["Binding to a sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672817", "l": "Active MTORC1 binds the ULK1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69667", "l": "H2O + luteolin 4'-O-beta-D-glucoside = beta-D-glucose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26495", "l": "chloride + FADH2 + L-tryptophan + O2 => 7-chloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507870", "l": "Aquaporins passively transport water out of cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10228", "l": "citrate = cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67571", "l": "3'-phosphoadenylyl sulfate + taurochenodeoxycholate <=> adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50359", "l": "4-hydroxy-6-methylpretetramide + NADPH + O2 <=> 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.1.-", "l": "\"Linked to oxidoreductase reactions\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696131", "l": "AOC1 deaminates Hist (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50765", "l": "4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine => 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72748", "l": "leukotriene E4(out) => leukotriene E4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30072", "l": "acetyl-CoA + butanoate => acetate + butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018804", "l": "RAC3 GEFs activate RAC3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21596", "l": "L-serine + NADP(+) = 2-aminomalonate semialdehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8957241", "l": "TP73 tetramer translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66756", "l": "ATP + domoate(in) + H2O = ADP + domoate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57771", "l": "2-nitrotoluene + NADH + O2 <=> 3-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17313", "l": "ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)", "d": [], "t": []}, {"i": "EC:6.1.1.21", "l": "\"histidine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59209", "l": "ATP + H(+) + octadecanoate => diphosphate + octadecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30289", "l": "9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol => 15-cis-phytoene + 2 a plastoquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109858", "l": "MAP2K2 binds MAPK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73505", "l": "3',4,7-trihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9824894", "l": "TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625324", "l": "FOXO1 binds SREBF1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11896", "l": "7alpha-hydroxycholesterol + NAD(+) = 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.181", "l": "\"cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15487", "l": "cis-homoaconitate + H2O => (2R,3S)-homoisocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47128", "l": "ATP + CoA + deoxycholate = AMP + deoxycholoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31121", "l": "(2E)-2-methylbut-2-enoyl-CoA + H2O => (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76542", "l": "a fatty acyl-CoA + sphinga-(4E,8E)-dienine <=> an N-acyl-sphinga-4,8-dienine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31862", "l": "(S)-2,3-epoxysqualene <=> glutinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45764", "l": "H2O + L-aspartate 4-semialdehyde + NAD(+) = 2 H(+) + L-aspartate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140164", "l": "Golgi transport complex binding", "d": ["Binding to a Golgi transport complex, a multisubunit tethering complex of the CATCHR family."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56654", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0033699", "l": "DNA 5'-adenosine monophosphate hydrolase activity", "d": ["Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17821", "l": "hydrogen cyanide + L-cysteine = 3-cyano-L-alanine + H(+) + hydrogen sulfide", "d": [], "t": []}, {"i": "EC:4.4.1.9", "l": "\"L-3-cyanoalanine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174202", "l": "Degradation of multiubiquitinated Securin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15970", "l": "2 glutathione + H(+) + methylarsonate => glutathione disulfide + H2O + methylarsonous acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0008301", "l": "DNA binding, bending", "d": ["The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696183", "l": "AOC3 deaminates BZAM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48455", "l": "a ganglioside GA2 (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73529", "l": "TDP(in) + UTP(out) => TDP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58369", "l": "(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) => (2E,6Z)-nona-2,6-dienal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592278", "l": "Autocatalytic activation of proMMP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59928", "l": "erythritol + NADP(+) = D-erythrose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64852", "l": "benzoyl-CoA + octan-1-ol = CoA + octyl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74151", "l": "acetyl-CoA + L-lysyl-[beta-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin]", "d": [], "t": []}, {"i": "EC:2.3.1.309", "l": "\"[beta-tubulin]-L-lysine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67194", "l": "ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate => ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62251", "l": "chloroacetaldehyde + H2O + NADP(+) <=> chloroacetate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.77", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44281", "l": "2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA => 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74494", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B <=> yaequinolone D", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74700", "l": "(5R)-hydroxy-beta-trans-bergamotene + O2 => (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22858", "l": "(7S)-O-acetylsalutaridinol + CoA => (7S)-salutaridinol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421495", "l": "Synthesis of ALAS2 nascent polypeptide (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38143", "l": "carbon disulfide + 2 H2O = CO2 + 2 H(+) + 2 hydrogen sulfide", "d": [], "t": []}, {"i": "EC:3.13.1.5", "l": "\"carbon disulfide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9663511", "l": "BIL binds GSTA1, FABP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380227", "l": "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018774", "l": "RHOBTB1 binds GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-844438", "l": "NLRP1 oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65620", "l": "hexadecanoyl-CoA + sphinga-(4E,8E)-dienine = CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9853878", "l": "FIGNL1 binds DMC1, RAD51 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9633044", "l": "ESR binds STRN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106264", "l": "protein serine kinase activity (using GTP as donor)", "d": ["Catalysis of the reactions: GTP + L-seryl-[protein] = GDP + H+ + O-phospho-L-seryl-[protein]."], "t": []}, {"i": "RHEA:64020", "l": "GTP + L-seryl-[protein] = GDP + H(+) + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58595", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69782", "l": "2-oxindole-3-acetate + succinyl-CoA <=> (2-oxoindol-3-yl)acetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21521", "l": "2 Fe(III)-[cytochrome b1] + formate => CO2 + 2 Fe(II)-[cytochrome b1] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694539", "l": "nsp15 binds nsp8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420131", "l": "The PACAP receptor binds PACAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.32", "l": "\"maleylacetate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18612", "l": "carbamoyl phosphate + N(2)-acetyl-L-ornithine <=> H(+) + N(2)-acetyl-L-citrulline + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16252", "l": "alpha-D-glucose 6-phosphate <=> beta-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78661", "l": "gamma-lactone-2-keto[5.5.5.5]fenestrane + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 2 O2 + 2 reduced [NADPH--hemoprotein reductase] + silphinene-15-oate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27434", "l": "2 glutathione amide + NAD(+) => glutathione amide disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665748", "l": "FMNL2 binds RHOC:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25461", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sibirene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24994", "l": "2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase] => L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55840", "l": "calcidiol + UDP-alpha-D-glucuronate = calcidiol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.16", "l": "\"versatile peroxidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877192", "l": "RUNX1 binds FOXP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28798", "l": "2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71670", "l": "PKM dephosphorylates PEP to PYR (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791235", "l": "GADD45A binds AURKA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237119", "l": "Acireductone is oxidized to MOB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56715", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] <=> H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071522", "l": "ureidoglycine aminohydrolase activity", "d": ["Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30639", "l": "(R)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.269", "l": "\"mannosylglycerate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71228", "l": "2 Na(+)(out) + selenocyanate(out) => 2 Na(+)(in) + selenocyanate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202216", "l": "Phosphorylation of SLP-76 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56323", "l": "a 5-hydroxy anthocyanidin + UDP-alpha-D-glucose <=> an anthocyanin 5-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44025", "l": "(3R)-3-hydroxydodecanoyl-CoA => (2E)-dodecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24523", "l": "H2O + L-saccharopine + NAD(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43063", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate <=> beta-D-glucose 1-phosphate + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015039", "l": "NADPH-adrenodoxin reductase activity", "d": ["Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59649", "l": "D-xylotriono-1,5-lactone + H2O => D-xylotrionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20899", "l": "ATP + hydrogencarbonate + urea <=> ADP + H(+) + phosphate + urea-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51984", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19553", "l": "H2O + L-tryptophan = indole + NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.99.1", "l": "\"tryptophanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018573", "l": "NOTCH3 binds activated EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42929", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63988", "l": "2-thiocytidine + ATP = 2-thiocytidine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0016420", "l": "malonyltransferase activity", "d": ["Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76810", "l": "(S)-isoleucinol + H2O + NAD(+) <=> (3S)-1-hydroxy-3-methylpentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0070643", "l": "vitamin D 25-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-25 of any form of vitamin D."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37134", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446372", "l": "Association of  PARVA with TESK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68075", "l": "Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH <=> L-thiazolidine-2-carboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37009", "l": "3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24449", "l": "enterobactin + UDP-alpha-D-glucose => monoglucosyl-enterobactin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55262", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24980", "l": "3-hydroxy-4-methylanthranilate + ATP + H(+) = 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.97", "l": "\"3-hydroxy-4-methylanthranilate adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55505", "l": "(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] => (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62574", "l": "glycine + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9704297", "l": "CHRM2 binds CHRM2 antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202703", "l": "CD47 binds SIRP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63025", "l": "(13Z)-docosenamide + H2O => (13Z)-docosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55294", "l": "H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine => pseudouridine(54) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029536", "l": "Expression of UGT1A3  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72425", "l": "(E)-4-coumaroyl-CoA + AMP + H(+) => (E)-4-coumaroyl-AMP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870269", "l": "Gastrin binds to CCK-B receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375395", "l": "C5a receptor binds C5a anaphylatoxin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13666", "l": "GTP => 3',5'-cyclic GMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65254", "l": "diphosphate + verruculide C => (2E,6E)-farnesyl diphosphate + 6-hydroxymellein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013021", "l": "GDIs block activation of RHOB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44290", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40579", "l": "1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73026", "l": "pregnenolone sulfate(out) <=> pregnenolone sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71126", "l": "(E)-caffeate + ATP + H(+) + 2 malonyl-CoA <=> AMP + 2 CO2 + 2 CoA + diphosphate + hispidin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680812", "l": "nsp7 binds nsp8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12774", "l": "2-oxoglutarate + O2 + proclavaminate => CO2 + dihydroclavaminate + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17273", "l": "(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) = 4-hydroxyphenylacetate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.53", "l": "\"4-hydroxyphenylacetaldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47378", "l": "(25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41359", "l": "bacteriochlorophyll a + 3 NADP(+) <=> geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008710", "l": "8-amino-7-oxononanoate synthase activity", "d": ["Catalysis of the reaction: L-alanine + H+ + pimelyl-CoA = 8-amino-7-oxononanoate + CO2 + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42185", "l": "5alpha-androstane-3beta,17beta-diol + NAD(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691131", "l": "CANDI binds CUL1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77702", "l": "a ganglioside GD1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GT1balpha  (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47583", "l": "a ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a ganglioside GT2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912627", "l": "CBL ubiquitinates PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22704", "l": "2 H2O + ricinine = 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.5.2", "l": "\"ricinine nitrilase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959462", "l": "SAMD8 transfers phosphatidyl from PE onto C16DH CER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22454", "l": "n H(+) + (n+1) phosphate => [phosphate](n+1) + n H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57611", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) <=> 3-chlorocatechol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12545", "l": "2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine => 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9035227", "l": "TXN2 binds CysS248-MPST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11184", "l": "3-(carbamoylamino)propanoate + 2 H(+) + H2O = beta-alanine + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75823", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] = 5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61766", "l": "H(+) + rebaudioside E + UDP => stevioside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40136", "l": "(9Z)-tetradecenoyl-CoA + H2O => (9Z)-tetradecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451283", "l": "kainate receptor binds glutamate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102378", "l": "steviolmonoside glucosyltransferase activity", "d": ["Catalysis of the reaction: steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37241", "l": "H(+) + uridine 2'-phosphate => 2',3'-cyclophospho-UMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34769", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+) => (6R)-5,10-methenyltetrahydrofolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749253", "l": "Formation of MCM2-7 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602466", "l": "Activation of MT-MMPs by FURIN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209160", "l": "Phosphorylated HOP phosphorylates DOME (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641111", "l": "Parkin transfers Ub to misfolded proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49734", "l": "CO2 + H2O + violacein => H(+) + O2 + violaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10875", "l": "H2O + N-acyl-L-aspartate <=> a carboxylate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73797", "l": "FAICAR => IMP + H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189406", "l": "4 PBGs bind to form HMB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65752", "l": "2-oxoglutarate + L-glutamate + O2 = (3R)-3-hydroxy-L-glutamate + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.76", "l": "\"L-glutamate 3(R)-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.3.2", "l": "\"xanthine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112155", "l": "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390597", "l": "Release Of ADP From Myosin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67542", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine => (9Z)-hexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.16", "l": "\"succinate-semialdehyde dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68713", "l": "(2E,6E)-farnesyl diphosphate => (1S,2S,4R)-beta-elemene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.11", "l": "\"neprilysin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61354", "l": "ADP + H(+) + phosphate + riboflavin(out) => ATP + H2O + riboflavin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170975", "l": "p-FRS2 binds CRKL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36482", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25685", "l": "L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.13", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43791", "l": "acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O <=> ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62468", "l": "3,4-dihydroxybenzoate + ATP + H(+) = 3,4-dihydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37887", "l": "S-adenosyl-L-methionine + small RNA 3'-end nucleotide = H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide", "d": [], "t": []}, {"i": "EC:2.1.1.386", "l": "\"small RNA 2'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53794", "l": "benzothialdehyde + H2O2 => benzylthiol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71924", "l": "2 Na(+)(out) + taurochenodeoxycholate(out) => 2 Na(+)(in) + taurochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30567", "l": "5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate = 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.33", "l": "\"tetrahydrosarcinapterin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63633", "l": "a long-chain fatty acyl-AMP + holo-[ACP] => a long-chain fatty acyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45788", "l": "(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol = 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38019", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol = 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10148", "l": "blasticidin S + H(+) + H2O = deaminohydroxyblasticidin S + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.23", "l": "\"blasticidin-S deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64165", "l": "2-methyl-L-serine => formaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9866272", "l": "2Fe-2S is inserted in UQCRFS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51763", "l": "a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19844", "l": "H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12876", "l": "(R)-2-hydroxy-4-methylpentanoate + NADP(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42693", "l": "[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate => [(1->4)-alpha-D-glucosyl](n+2) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051380", "l": "norepinephrine binding", "d": ["Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14427", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33186", "l": "citrate(in) <=> citrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28851", "l": "melibiose(in) + Na(+)(in) = melibiose(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18471", "l": "an N(2)-acyl-L-glutamine + CoA + H(+) => an acyl-CoA + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682826", "l": "LGI1 binds ADAM11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61059", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10994", "l": "glyoxylate + H(+) + NADPH => glycolate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17770", "l": "choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30268", "l": "2 monodehydro-L-ascorbate radical => L-ascorbate + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14574", "l": "D-glucarate => 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730599", "l": "Phosphorylated STAT3 Dimer Translocates to the Nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12714", "l": "a nucleoside 5'-phosphate + ATP => a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51397", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin => CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43873", "l": "3-oxochol-4-en-22-oate + ATP + CoA => 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008748", "l": "N-ethylmaleimide reductase activity", "d": ["Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0140223", "l": "general transcription initiation factor activity", "d": ["A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41269", "l": "(15Z)-tetracosenoate + sphing-4-enine => H2O + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109700", "l": "AKT2 binds PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51709", "l": "D-altritol + NAD(+) => H(+) + keto-D-tagatose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.206", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61382", "l": "2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate => 2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682311", "l": "Defective ABCA12 does not transport lipids from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67543", "l": "(9Z)-hexadecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18851", "l": "a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.2", "l": "\"NAD(P)H dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088207", "l": "Golgi lumen glycoconjugates translocate to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46895", "l": "2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate <=> 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748991", "l": "XDH oxidises 6MP to 6TU (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018647", "l": "phenanthrene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9675026", "l": "Formation of the MLL1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944457", "l": "MAF1 translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78453", "l": "a fatty acid + a lysoGb3 => a globoside Gb3Cer + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58046", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA => a long-chain fatty acyl-CoA + alpha,alpha-trehalose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061658", "l": "URM1 conjugating enzyme activity", "d": ["Isoenergetic transfer of URM1 from one protein to another via the reaction X-URM1 + Y = Y-URM1 + X, where both the X-URM1 and Y-URM1 linkages are thioester bonds between the C-terminal amino acid of URM1 and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006050", "l": "MECP2:SIN3A complex binds the promoter of the BDNF gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448427", "l": "Interleukin-27 binds Interleukin-27 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57752", "l": "2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50856", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51996", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836702", "l": "PKR inhibitors bind PKR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018493", "l": "formylmethanofuran dehydrogenase activity", "d": ["Catalysis of the reaction: N-formylmethanofuran + A + H2O + H+ = AH(2) + CO2 + methanofuran."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61320", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796368", "l": "RIPK1 binds STUB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64856", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + phomopsene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12621", "l": "H(+) + L-aspartate = CO2 + L-alanine", "d": [], "t": []}, {"i": "EC:4.1.1.12", "l": "\"aspartate 4-decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2632521", "l": "at-retinyl is hydrolysed from p-MII:SAG to release atRAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47753", "l": "5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine => 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20039", "l": "aldehydo-D-glucose 6-phosphate + H(+) + NADPH => D-sorbitol 6-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71181", "l": "FAH cleaves 4FAA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0008198", "l": "ferrous iron binding", "d": ["Binding to a ferrous iron ion, Fe(II)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873926", "l": "IFNG dimer binds IFNGR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947531", "l": "Molybdenum ion transfer onto molybdopterin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44531", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11855", "l": "phosphate + S-methyl-5'-thioadenosine <=> adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75187", "l": "TRAIL:TRAIL receptor trimers bind FADD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60721", "l": "(E)-hept-2-enal + H2O + NADP(+) => (E)-hept-2-enoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72755", "l": "3 ATP = 3',3',3'-c-tri-AMP + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59967", "l": "L-seryl-[protein] + octanoyl-CoA <=> CoA + O-octanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58805", "l": "5'-pApG-3' + H2O => 5'-ApG-3' + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038046", "l": "G protein-coupled enkephalin receptor activity", "d": ["Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046970", "l": "NAD-dependent histone H4K16 deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20468", "l": "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014454", "l": "RHOG translocates to the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9834807", "l": "ILF3 binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66281", "l": "solanidine + UDP-alpha-D-glucose => H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68546", "l": "(E)-beta-farnesene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9825783", "l": "p-S207 KARS1 dimer translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38934", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72103", "l": "Formation of pre-mRNPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16137", "l": "2'-deoxymugineate + NADP(+) = 3''-deamino-3''-oxonicotianamine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.36", "l": "\"alcohol dehydrogenase (nicotinoprotein)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870465", "l": "RGGT binds the RAB-binding subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19744", "l": "formyl-CoA + H2O <=> CoA + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24190", "l": "1,2-dihydroxydibenzothiophene + H(+) + NADH => cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61041", "l": "(+)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] => (+)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54496", "l": "ent-copalyl diphosphate = diphosphate + ent-atiserene", "d": [], "t": []}, {"i": "EC:4.2.3.185", "l": "\"ent-atiserene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49083", "l": "dibenzothiophene 5-oxide + FMNH2 + O2 <=> dibenzothiophene 5,5-dioxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60685", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) => (11R)-dihydroartemisinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19469", "l": "NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042279", "l": "nitrite reductase (cytochrome, ammonia-forming) activity", "d": ["Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202127", "l": "eNOS synthesizes NO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140902", "l": "L-glutamine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamine(out) + Na+(out) = L-glutamine(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53117", "l": "an 11beta-hydroxysteroid + NAD(+) => an 11-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29816", "l": "ATP + H2O + L-proline(out) => ADP + H(+) + L-proline(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396399", "l": "Fibrillins bind BMPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17517", "l": "H2O + N-(long-chain-fatty-acyl)-L-glutamate = a long-chain fatty acid + L-glutamate", "d": [], "t": []}, {"i": "EC:3.5.1.55", "l": "\"long-chain-fatty-acyl-glutamate deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46437", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36635", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.282", "l": "\"tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904493", "l": "tetrahydrofolyl-poly(glutamate) polymer binding", "d": ["Binding to tetrahydrofolyl-poly(glutamate) polymer."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41097", "l": "H(+) + phosphocholine + sphing-4-enine => H2O + sphing-4-enine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9010815", "l": "SLITs bind keratan sulfate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3828025", "l": "DCN (decorin) degradation by MMP14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450494", "l": "HuR binds mRNAs in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31224", "l": "cis-beta-D-glucosyl-2-hydroxycinnamate + H2O => beta-D-glucose + cis-2-coumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76581", "l": "(6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + NADP(+) => (2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77635", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018807", "l": "RAC3 GDIs block activation of RAC3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28713", "l": "H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out) => H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.45", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218815", "l": "p-6Y-VEGFR2 binds NCK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53126", "l": "delta-carotene => all-trans-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59138", "l": "AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine => ATP + citrate + D-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38881", "l": "a fatty acid(out) => a fatty acid(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46482", "l": "4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32146", "l": "L-arginine(in) <=> L-arginine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786101", "l": "IL4 binds IL4R:JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757688", "l": "SERPINA6 binds PREDN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33377", "l": "a 1-acyl-sn-glycero-3-phosphate + NADP(+) => a 1-acylglycerone 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77963", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (5R,12R,14S)-dolasta-1(15),8-diene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.214", "l": "\"dolasta-1(15),8-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74730", "l": "Insulin degradation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707516", "l": "FeHM dissociates from MetHb (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42722", "l": "2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2552) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55443", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + maniladiol + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33691", "l": "2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41254", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate <=> 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72543", "l": "2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) = 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52135", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O <=> a 5'-end 5'-phospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050581", "l": "D-mannitol oxidase activity", "d": ["Catalysis of the reaction: mannitol + O2 = mannose + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167408", "l": "The high affinity receptor complex binds to G-protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66571", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> preluffariellolide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60326", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672980", "l": "Dissociation of RAS:RAF complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51564", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.29", "l": "\"cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13481", "l": "ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)", "d": [], "t": []}, {"i": "EC:6.1.1.10", "l": "\"methionine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102146", "l": "tricetin O-methytransferase activity", "d": ["Catalysis of the reaction: tricetin + S-adenosyl-L-methionine = H+ + 3'-O-methyltricetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48614", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase] => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59222", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+) => (2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72395", "l": "2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) + K(+)(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10239", "l": "trans-2-coumarate + UDP-alpha-D-glucose <=> H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75856", "l": "Abortive Initiation Before Second Transition (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170003", "l": "heme B transmembrane transporter activity", "d": ["Enables the transfer of heme B from one side of a membrane to the other."], "t": []}, {"i": "RHEA:75443", "l": "heme b(in) = heme b(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40272", "l": "O2 + tetradecanedioyl-CoA => (2E)-tetradecenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645598", "l": "RRAGC,D hydrolyzes GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701507", "l": "PTPN6 dephosphorylates JAK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31919", "l": "indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.157", "l": "\"indolin-2-one monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10936", "l": "6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate", "d": [], "t": []}, {"i": "EC:1.8.5.2", "l": "\"thiosulfate dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192704", "l": "Synthesis of PB1-F2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73887", "l": "chloride(out) + Na(+)(out) = chloride(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56809", "l": "ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] => adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10248", "l": "dUTP + H2O = diphosphate + dUMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18632", "l": "ATP + NAD(+) <=> ADP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39129", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44173", "l": "H2O + NAD(+) + tetradecanal => 2 H(+) + NADH + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227860", "l": "ITCH homolog downregulates MDA5/IPS1 signaling   (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67860", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] = 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36253", "l": "(E)-feruloyl-CoA + AMP + diphosphate => (E)-ferulate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682026", "l": "MRN bound to shortened telomeres activates ATM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11254", "l": "beta-L-aspartylhydroxamate + NH4(+) => H(+) + hydroxylamine + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229132", "l": "AP4 binds APP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854052", "l": "Formation of the SCF-FBXL7 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61448", "l": "H(+) + NADPH + O2 + tigecycline = 11a-hydroxytigecycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21249", "l": "a ribonucleoside 5'-triphosphate + RNA(n) => diphosphate + RNA(n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41745", "l": "3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38382", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209910", "l": "Iodide is taken up by thyroid epithelial cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14226", "l": "6-hydroxyhexanoate + NAD(+) => 6-oxohexanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856546", "l": "MLXIPL:MLX binds FASN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74712", "l": "5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine => 5-dehydrofumagillol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62353", "l": "H(+) + NADPH + notoamide E + O2 => H2O + NADP(+) + notoamide D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72688", "l": "all-trans-retinol(out) => all-trans-retinol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63513", "l": "biphenyl-2,2'-diol + H(+) + NADH + O2 => biphenyl-2,2',3-triol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858387", "l": "Activated STAT3 positively regulates CEBPB transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389532", "l": "PP2A binds CTLA4 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18475", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP => 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004493", "l": "methylmalonyl-CoA epimerase activity", "d": ["Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11334", "l": "diphosphate + RNA(n)-3'-adenine ribonucleotide => ATP + RNA(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16723", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n) => 5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693347", "l": "HTR1A binds 5HT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66863", "l": "dimethylallyl diphosphate + 4 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46909", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37305", "l": "ADP + glycyl-L-asparagine(in) + H(+) + phosphate => ATP + glycyl-L-asparagine(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67037", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2 => (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17538", "l": "(R)-carnitinamide + H2O => (R)-carnitine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35508", "l": "30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27808", "l": "acetate + acetoacetyl-CoA => acetoacetate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77574", "l": "a 1-acylglycerol + an acyl-CoA <=> a 1,3-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218832", "l": "CDC42:GTP binds PAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26349", "l": "beta-L-galactose 1-phosphate + H2O = L-galactose + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.93", "l": "\"L-galactose 1-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38388", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22362", "l": "5-oxo-D-proline + H2O => D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26390", "l": "all-trans-beta-carotene + O2 => all-trans-10'-apo-beta-carotenal + beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45990", "l": "3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O => 3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.103234640867726", "identifiers": [{"i": "GO:0019904", "l": "protein domain specific binding", "d": ["Binding to a specific domain of a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419861", "l": "Melanospin is stimulated by light (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158399", "l": "kallikrein binds SERPING1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26077", "l": "methanesulfonate + NADH + O2 = formaldehyde + H2O + NAD(+) + sulfite", "d": [], "t": []}, {"i": "EC:1.14.13.111", "l": "\"methanesulfonate monooxygenase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73595", "l": "CTP(out) + dUMP(in) = CTP(in) + dUMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9761027", "l": "ZEB2 binds SP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014456", "l": "GDIs block activation of RHOG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65919", "l": "L-kynurenine + pyruvate <=> H2O + kynurenate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65654", "l": "a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12649", "l": "L-rhamnofuranose + NAD(+) = H(+) + L-rhamnono-1,4-lactone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418579", "l": "Gq activation by P2Y purinoceptor 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56935", "l": "androst-5-en-3beta,17beta-diol + NAD(+) <=> 17beta-hydroxy-androst-5-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39894", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine <=> dTDP + H(+) + vancomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621404", "l": "CYP51A1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36010", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43302", "l": "a neolactoside IV(4)-beta-GalNAc-IV(3)-alpha-NeuGc-nLc4Cer + H(+) + UDP => a neolactoside IV(3)-alpha-NeuGc-nLc4Cer + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36947", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102731", "l": "D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity", "d": ["Catalysis of the reaction: myo-inositol 1,3,4,6-tetrakisphosphate(8-) + ATP = H+ + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ADP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18643", "l": "a menaquinol => a menaquinone + H2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043212", "l": "carbohydrate-exporting ABC transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) -> ADP + phosphate + carbohydrate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390886", "l": "HRH4 binds Hist (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38063", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30205", "l": "2 GDP + 2 H(+) => H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15011", "l": "7,8-dihydrofolate + H(+) + NADPH => (6S)-5,6,7,8-tetrahydrofolate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17302", "l": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] => ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36353", "l": "3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine => AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34157", "l": "CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose => acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159773", "l": "Furin cleaves pro-protein S to protein S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49784", "l": "chenodeoxycholoyl-CoA + taurine = CoA + H(+) + taurochenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69325", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate => 4-methylsulfanylbutyl isothionate + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694308", "l": "3a is externalized together with membrane structures (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71792", "l": "(R)-lactate(in) + H(+)(in) => (R)-lactate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005119", "l": "smoothened binding", "d": ["Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52393", "l": "ATP + D-erythronate => 4-phospho-D-erythronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201630", "l": "Caspase-mediated cleavage of Acinus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72186", "l": "creatinine(in) + H(+)(out) <=> creatinine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005157", "l": "macrophage colony-stimulating factor receptor binding", "d": ["Binding to a macrophage colony-stimulating factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65456", "l": "2-methylbutan-1-ol + acetyl-CoA = 2-methylbutyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45238", "l": "(25R)-3beta-hydroxy-5-cholestenoate + H2O + 2 oxidized [adrenodoxin] => (25R)-3beta-hydroxy-5-cholesten-26-al + H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46979", "l": "(S)-6-hydroxynicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002466", "l": "Formation of allysine by LOX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59227", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + hydropyrene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26025", "l": "(3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal => 8'-apo-beta-carotenol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847880", "l": "CYTH proteins bind ARF1:GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35885", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26161", "l": "(S)-2,3-epoxysqualene => thalianol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54533", "l": "H2O + N-(4-oxoglutaryl)-L-cysteinylglycine => 2-oxoglutarate + L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34243", "l": "GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide", "d": [], "t": []}, {"i": "EC:2.7.7.77", "l": "\"molybdenum cofactor guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070674", "l": "hypoxanthine dehydrogenase activity", "d": ["Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+."], "t": []}, {"i": "REACT:R-HSA-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65818", "l": "A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate => AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112703", "l": "PTPN11 is phosphorylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71184", "l": "L-kynurenine(out) + L-tryptophan(in) => L-kynurenine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38982", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35667", "l": "a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168947", "l": "Ligand binds to TLR10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021050", "l": "HSBP1 oligomer binds ESRs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132201", "l": "Opsonization with C3b or C4b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.3.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.98.5", "l": "\"tetraether lipid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16410", "l": "1,2-dihydrovomilenine + NADP(+) => H(+) + NADPH + vomilenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404134", "l": "RBP4:atROL binds TTR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24362", "l": "Fe(2+) + sirohydrochlorin => 2 H(+) + siroheme", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200555", "l": "Formation of Malonyl-CoA from Acetyl-CoA (liver) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49546", "l": "2-dehydro-3-deoxy-D-gluconate + NH4(+) => (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51225", "l": "2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate => 2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696274", "l": "RND1 binds GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63001", "l": "(11Z,14Z,17Z)-eicosatrienamide + H2O => (11Z,14Z,17Z)-eicosatrienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446634", "l": "IRAK4 is activated by autophosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46471", "l": "an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O <=> ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61815", "l": "3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose <=> dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22986", "l": "N-carbamoyl-2-oxoglycine + phosphate => carbamoyl phosphate + oxamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046029", "l": "mannitol dehydrogenase activity", "d": ["Catalysis of the reaction: D-mannitol + NAD+ = D-mannose + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68544", "l": "(2Z,6Z)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16945", "l": "(6S)-5,6,7,8-tetrahydrofolate + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NH4(+)", "d": [], "t": []}, {"i": "EC:2.1.2.10", "l": "\"aminomethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37665", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674093", "l": "PDGFRs bind type I TKI (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38439", "l": "(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64611", "l": "L-threonyl-[protein] + UTP <=> diphosphate + uridylyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389532", "l": "PP2A binds CTLA4 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11646", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2R,3R)-flavan-3-ol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38345", "l": "(20S)-ginsenoside Rg3 + D-glucose => (20S)-ginsenoside Rd + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15299", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73999", "l": "dimethylallyl diphosphate + quinolinone B = diphosphate + peniprequinolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015516", "l": "tartrate:succinate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15090", "l": "(R)-lactate + A => AH2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12579", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose <=> (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0042017", "l": "interleukin-22 binding", "d": ["Binding to interleukin-22."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250220", "l": "Homodimerization of ERBB4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71230", "l": "2 Na(+)(out) + selenocyanate(out) <=> 2 Na(+)(in) + selenocyanate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41116", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374669", "l": "L1 binds NRP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69192", "l": "ATP + L-glutamate + L-glutamyl-[tubulin] = ADP + gamma-L-glutamyl-L-glutamyl-[tubulin] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391942", "l": "IP receptor can bind prostacyclin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59678", "l": "D-maltotetraono-1,5-lactone + H2O2 => D-maltotetraose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45558", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine => H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50280", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52029", "l": "a jasmonyl-L-amino acid + H2O => a jasmonate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69701", "l": "beta-D-glucose + N-hexadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801415", "l": "TP53 stimulates NLRC4 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874187", "l": "MBTPS2 (S2P) cleaves CREB3L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052918", "l": "dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64755", "l": "3-sulfanylpentan-1-ol-L-cysteine + H2O <=> 3-sulfanyl-1-pentanol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58330", "l": "(Z)-non-6-enal + H(+) + NADPH => (Z)-non-6-en-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46641", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH => 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-881988", "l": "CRY is phosphorylated by SGG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035804", "l": "structural constituent of egg coat", "d": ["The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64604", "l": "L-seryl-[protein] + UTP = diphosphate + uridylyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78200", "l": "a 3beta-hydroxysteroid + a triacylglycerol => a 1,3-diacylglycerol + a 3beta-hydroxysteroid ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9837978", "l": "LONP1 binds mitochondrial inner membrane proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.19", "l": "\"procollagen C-endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034930", "l": "1-hydroxypyrene sulfotransferase activity", "d": ["Catalysis of the reaction: 1-hydroxypyrene + XSO3- = 1-pyrenylsulfate + HX."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32039", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = AMP + ATP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-481007", "l": "Exocytosis of platelet alpha granule contents (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785213", "l": "LIPC dimer binds heparin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36689", "l": "CoA + H(+) + N-hexadecanoylsphing-4-enine => hexadecanoyl-CoA + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58054", "l": "(2-acetamidoethyl)phosphonate + CoA + H(+) => (2-aminoethyl)phosphonate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76134", "l": "3',5'-cyclic GMP(out) + a dicarboxylate(in) <=> 3',5'-cyclic GMP(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54756", "l": "deamido-NAD(+) + hydrogencarbonate = AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": [], "t": []}, {"i": "EC:2.5.1.143", "l": "\"pyridinium-3,5-biscarboxylic acid mononucleotide synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197698", "l": "Src phosphorylate WASP,N-WASP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465940", "l": "atRAL is reduced to atROL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14843", "l": "ent-copalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832187", "l": "Expression of JAG1 during nephron development (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29443", "l": "H(+)(in) + L-alanine(in) = H(+)(out) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030760", "l": "pyridine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76137", "l": "a dicarboxylate(out) + urate(in) => a dicarboxylate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75898", "l": "holothin + marinoloyl-CoA C <=> CoA + thiomarinol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65268", "l": "3-hydroxypentacecilide A + H(+) + NADPH + O2 = chrodrimanin F + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70190", "l": "alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose <=> cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70692", "l": "ornithine => putrescine + CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404131", "l": "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55085", "l": "(3R)-3-hydroxypentanoyl-CoA + H2O => (3R)-3-hydroxypentanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37413", "l": "aklaviketone + 2 H(+) + NADPH => aklavinone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030346", "l": "protein phosphatase 2B binding", "d": ["Binding to a protein phosphatase 2B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0031877", "l": "somatostatin receptor binding", "d": ["Binding to a somatostatin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139941", "l": "Binding of IP3 to IP3 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483087", "l": "PI is exchanged with PC by PITPNB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37932", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73173", "l": "adenosine 3',5'-bisphosphate(in) + NAD(+)(out) => adenosine 3',5'-bisphosphate(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46272", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34284", "l": "2 L-tyrosine + O2 => 2 L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72388", "l": "2 hydrogencarbonate(out) + sulfate(in) => 2 hydrogencarbonate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855232", "l": "RELN:VLDLR binds DAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44369", "l": "Cr(6+) + 2 NADPH + O2 => Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15263", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66255", "l": "ATP + CoA + IC-asc-C7 <=> AMP + diphosphate + IC-asc-C7-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686587", "l": "ABL1 phosphorylates RAD52 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54562", "l": "a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+) => a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51212", "l": "(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11987", "l": "AH2 + O2 + progesterone <=> A + H2O + testosterone acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684352", "l": "nsp3-4 cleaves itself (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952128", "l": "RUNX3 binds TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58874", "l": "4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65777", "l": "chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46843", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445124", "l": "Patched binds Smoothened (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203712", "l": "eNOS associates with Caveolin-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53754", "l": "a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73573", "l": "(E,E)-piperoyl-CoA + AMP + diphosphate => (E,E)-piperate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59840", "l": "(6S)-5,6,7,8-tetrahydrofolate + syringate = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940134", "l": "FOLR2 binds FOLA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27654", "l": "2-oxobutanoate + H(+) + pyruvate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65758", "l": "(2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] => 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24850", "l": "3,4-dihydroxybenzoate + H2O => 3-dehydroshikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42371", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60506", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+) => 1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46261", "l": "an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61767", "l": "stevioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside E + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799332", "l": "ATR phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73954", "l": "(2E,6E)-farnesyl diphosphate <=> beta-maaliene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60074", "l": "4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+) => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162657", "l": "Inactivation of Myt1 kinase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19038", "l": "an epoxide + H2O => an ethanediol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389756", "l": "AKT interacts and phosphorylates Cot (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55485", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22813", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) => (6R)-5,10-methenyltetrahydrofolate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41780", "l": "beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36142", "l": "(E)-hexadec-2-enoate + ATP + CoA <=> (2E)-hexadecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19927", "l": "D-ribulose 5-phosphate + H(+) + NADH => D-ribitol 5-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047386", "l": "fructose-2,6-bisphosphate 6-phosphatase activity", "d": ["Catalysis of the reaction: beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructofuranose 2-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50214", "l": "11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58010", "l": "(20S)-ginsenoside Rg1 + H(+) + UDP => (20S)-ginsenoside F1 + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10123", "l": "adenosine in double-stranded RNA + H(+) + H2O <=> inosine in double-stranded RNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25541", "l": "ent-copalyl diphosphate => diphosphate + ent-pimara-8(14),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28889", "l": "H(+)(out) + L-serine(out) => H(+)(in) + L-serine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371422", "l": "ATP hydrolysis by HSP70 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50772", "l": "H2O + nitroethane + O2 = acetaldehyde + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14774", "l": "2 NADPH + palmatine + S-adenosyl-L-methionine => corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692539", "l": "HRH1 binds HRH1 inverse agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1878002", "l": "XYLTs transfer Xyl to core protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75172", "l": "Formation of RAD50:MRE11 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40146", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O <=> (9Z,12Z)-octadecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68112", "l": "H2O + propanamide = NH4(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30040", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 => benzene-1,2,4-triol + CO2 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:1902444", "l": "riboflavin binding", "d": ["Binding to riboflavin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61799", "l": "holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP <=> AMP + L-tryptophyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46915", "l": "H2O + juvenile hormone III <=> H(+) + juvenile hormone III carboxylate + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0032552", "l": "deoxyribonucleotide binding", "d": ["Binding to a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72140", "l": "estrone 3-sulfate(in) + H(+)(out) => estrone 3-sulfate(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33882", "l": "2-deoxy-scyllo-inosamine + NADP(+) <=> 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784861", "l": "HSPG binds LPL dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42713", "l": "S-adenosyl-L-methionine + uridine(54) in tRNA => 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011958", "l": "miR-26A and B bind to the 3'UTR of the GREB1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129362", "l": "Fibrillin microfibril assembly (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60722", "l": "(E)-hept-2-enoate + 2 H(+) + NADPH => (E)-hept-2-enal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66844", "l": "asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] = asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113446", "l": "Initiation of RNA Polymerase III Productive Transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17251", "l": "6 H(+) + 2 iron(III) oxide-hydroxide => 2 Fe(2+) + 2 H2O + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028598", "l": "Phosphorylation of YAP by LATS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42111", "l": "(20S)-hydroxypregn-4-en-3-one + NAD(+) <=> H(+) + NADH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002460", "l": "P4HB binds Collagen chains (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449077", "l": "Interleukin-16 is secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869549", "l": "TFPA2A homodimer and NPM1 bind the MYBL2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48746", "l": "(-)-deoxypodophyllotoxin + CO2 + H2O + succinate => (-)-yatein + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16589", "l": "A + sucrose = 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2", "d": [], "t": []}, {"i": "EC:1.1.99.13", "l": "\"glucoside 3-dehydrogenase (acceptor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54586", "l": "an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine => a guanosine in 18S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24307", "l": "glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] <=> CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76237", "l": "a tRNA with a 3' CCACCA end + 3 diphosphate => a tRNA with a 3' CCA end + ATP + 2 CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004780", "l": "sulfate adenylyltransferase (ADP) activity", "d": ["Catalysis of the reaction: ADP + H+ + sulfate = 5'-adenylyl sulfate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44622", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140332", "l": "lipopolysaccharide transfer activity", "d": ["Removes a lipopolysaccharide (LPS) from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110453", "l": "Phosphorylation of PIP2 to PIP3 by Dp110 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735143", "l": "NKX2-5 binds the GATA4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65485", "l": "hexan-1-ol + hexanoyl-CoA => CoA + hexyl hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67686", "l": "a long-chain fatty acid(out) + ADP + H(+) + phosphate => a long-chain fatty acid(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27704", "l": "keto-D-tagaturonate => aldehydo-D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647994", "l": "RAS proteins are depalmitoylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38715", "l": "ATP + choline(out) + H2O = ADP + choline(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061666", "l": "UFM1 ligase activity", "d": ["Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S = X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10172", "l": "(3R)-hydroxybutanoate dimer + H2O = 2 (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.22", "l": "\"hydroxybutyrate-dimer hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11720", "l": "ATP + 2 H2O + N-methylhydantoin = ADP + 2 H(+) + N-carbamoylsarcosine + phosphate", "d": [], "t": []}, {"i": "EC:3.5.2.14", "l": "\"N-methylhydantoinase (ATP-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55102", "l": "(3R)-hydroxypentanoyl-[ACP] + NADP(+) => 3-oxopentanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9015111", "l": "Factor Xa inhibitors binds Xa (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76844", "l": "H2O + NAD(+) + octylamine => H(+) + NADH + NH4(+) + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003735", "l": "structural constituent of ribosome", "d": ["The action of a molecule that contributes to the structural integrity of the ribosome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65267", "l": "3-hydroxypentacecilide A + A <=> AH2 + chrodrimanin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50106", "l": "CoA + H(+) + N-tetradecanoyl-taurine => taurine + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74900", "l": "(2E)-2-butenoate + ATP + holo-[ACP] => (2E)-butenoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050582", "l": "xylitol oxidase activity", "d": ["Catalysis of the reaction: xylitol + O2 = xylose + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55005", "l": "1-hydroxylimonen-2-one + NADPH + O2 => 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18100", "l": "pteridine-2,4,6,7-tetrol <=> H(+) + xanthine-8-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73306", "l": "H(+)(in) + oxaloacetate(out) + phosphate(in) <=> H(+)(out) + oxaloacetate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49092", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210273", "l": "Interaction of DAP12 and NKp44 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848939", "l": "PTK6 binds KHDRBS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796060", "l": "NFE2L2 dependent NFE2L2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29691", "l": "alpha-maltotetraose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37103", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.12", "l": "\"ribonuclease E\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008488", "l": "gamma-glutamyl carboxylase activity", "d": ["Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75946", "l": "beta-alanine + L-arginine <=> 3-guanidinopropanoate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33145", "l": "galactitol(out) => galactitol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65804", "l": "a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9732729", "l": "Activated JAK1 binds RAF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29980", "l": "2'-deoxyadenosine(in) + H(+)(in) => 2'-deoxyadenosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47198", "l": "a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380930", "l": "Phosphorylated AMPK binds AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008962", "l": "phosphatidylglycerophosphatase activity", "d": ["Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839377", "l": "TGFB1,TGFB2 bind TGFBR3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610720", "l": "PKA phosphorylates GLI3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31142", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) <=> 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66232", "l": "IC-asc-C7-CoA + O2 = H2O2 + IC-asc-DeltaC7-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33957", "l": "DIBOA beta-D-glucoside + H(+) + UDP => DIBOA + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30436", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13822", "l": "2-oxoglutarate + glutarate + O2 => (S)-2-hydroxyglutarate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.2.-", "l": "\"In P-halide compounds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11648", "l": "(-)-menthol + H(+) + NADPH + O2 = 1,4-menthane-3,8-diol + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.46", "l": "\"(-)-menthol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102083", "l": "7,8-dihydromonapterin aldolase activity", "d": ["Catalysis of the reaction: 7,8-dihydromonapterin = glycolaldehyde + 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665696", "l": "ERBB2 TMD/JMD mutants bind trastuzumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.2.-", "l": "\"With ascorbate as one donor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102145", "l": "(3R)-(E)-nerolidol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (3R,6E)-nerolidol + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388831", "l": "Phosphorylation of CD28 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029268", "l": "Phosphorylation and activation of PLCG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12494", "l": "D-methionine => L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58315", "l": "25-substituted-cholesteryl beta-D-glucoside + H2O <=> 25-substituted-cholesterol + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54554", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate => 1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62890", "l": "beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+) => GDP-beta-L-fucose + lactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481007", "l": "Exocytosis of platelet alpha granule contents (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001618", "l": "virus receptor activity", "d": ["Combining with a virus component and mediating entry of the virus into the cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12662", "l": "(R)-carnitine + hexadecanoyl-CoA => CoA + O-hexadecanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38621", "l": "H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside => nicotinate beta-D-ribonucleotide + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2077420", "l": "FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15546", "l": "(3S)-citramalate => acetate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15960", "l": "D-altronate <=> 2-dehydro-3-deoxy-D-gluconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9853499", "l": "DLD dimer dehydrogenates dihydrolipoyl (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186773", "l": "PDGF dimer binds two receptors simultaneously (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3321883", "l": "MSL acetylates histone H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209082", "l": "Further phosphorylation of APC by SGG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65105", "l": "aculene D + L-prolyl-[peptidyl-carrier protein] => aculene B + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9824977", "l": "MAPK1-dependent phosphorylation of MITF-M (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25284", "l": "(S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200555", "l": "Formation of Malonyl-CoA from Acetyl-CoA (liver) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008495", "l": "protoheme IX farnesyltransferase activity", "d": ["Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0019156", "l": "isoamylase activity", "d": ["Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73986", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-beta-barbatene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21850", "l": "(Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide => (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21191", "l": "ATP + deamido-NAD(+) + NH4(+) <=> AMP + diphosphate + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66469", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O => (17E)-cheilanthenediol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60257", "l": "A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] => AH2 + formaldehyde + L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796617", "l": "MIB2 binds CFLAR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163549", "l": "phosphorylated HSL dimer + FABP4 -> phosphorylated HSL dimer:FABP4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49367", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) <=> 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018805", "l": "benzylsuccinate synthase activity", "d": ["Catalysis of the reaction: fumarate + toluene = 2-benzylsuccinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928624", "l": "EPHBs bind EFNBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36203", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20780", "l": "ATP + GMP = ADP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22072", "l": "ATP + L-ribulose = ADP + H(+) + L-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963864", "l": "CUBN dissociates from 25(OH)D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673756", "l": "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382053", "l": "Translocation of PDGF from ER to Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990137", "l": "plant seed peroxidase activity", "d": ["Catalysis of the reaction: R1H + R2OOH = R1OH + R2OH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61527", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0001050", "l": "single-subunit type RNA polymerase binding", "d": ["Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20234", "l": "a 7beta-hydroxysteroid + NADP(+) => a 7-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56961", "l": "a ribonucleoside 5'-triphosphate + pyruvate => a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985591", "l": "SLIT2-bound ROBO1 binds MYO9B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13076", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O <=> guanosine 3',5'-bis(diphosphate) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22270", "l": "ADP + H(+) + streptomycin 6-phosphate => ATP + streptomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60045", "l": "beta-D-Gal-(1<->1')-Cer + UDP-alpha-D-galactose => alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70517", "l": "3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44481", "l": "3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018481", "l": "4-hydroxymuconic-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: <stereo>cis,trans</stereo>-4-hydroxymuconate semialdehyde + H2O + NAD+ = 2 H+ + maleylacetate + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59700", "l": "D-cellopentaono-1,5-lactone + H2O = D-cellopentaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052847", "l": "inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity", "d": ["Catalysis of the reaction: 1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004157", "l": "dihydropyrimidinase activity", "d": ["Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022398", "l": "ACE:Zn2+ hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210426", "l": "Glutamate synaptic vesicle docking and priming (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299318", "l": "Activation of TASK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981926", "l": "RAC1 and CDC42 activate PAK3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76963", "l": "2-hexyl-5-heptylresorcinol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hexyl-5-(7-hydroxyheptyl)resorcinol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11851", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine <=> [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45889", "l": "12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69299", "l": "CDT1 binds geminin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22661", "l": "a fatty acid + ATP + holo-[ACP] => a fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-377644", "l": "Release of CSK from SRC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015143", "l": "urate transmembrane transporter activity", "d": ["Enables the transfer of urate from one side of a membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17211", "l": "2-formylglutarate + NH4(+) => 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783670", "l": "CRLF1 binds CLCF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13075", "l": "guanosine 3',5'-bis(diphosphate) + H(+) + phosphate => guanosine 3'-diphosphate 5'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74341", "l": "O-3-methylbutanoyl-(R)-carnitine(out) => O-3-methylbutanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42203", "l": "corticosterone + NADP(+) <=> 11-dehydrocorticosterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43447", "l": "1,2-ditetradecanoyl-sn-glycerol + ATP <=> 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099108", "l": "potassium channel activator activity involved in G protein-coupled receptor signaling pathway", "d": ["Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23513", "l": "alpha,alpha-trehalose + phosphate => beta-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43999", "l": "2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2 <=> a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140679", "l": "ABC-type sodium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na(in) = ADP + phosphate + Na(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614544", "l": "Sulfite is oxidized to sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50998", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine => L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19045", "l": "acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.21", "l": "\"(R)-citramalate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350058", "l": "Formation of CSL NCOR corepressor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77183", "l": "L-threonine + uridine-5'-aldehyde = (5'S,6'S)-C-glycyluridine + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46771", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65810", "l": "dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60364", "l": "H(+)(out) + myo-inositol(out) = H(+)(in) + myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75783", "l": "ADP(in) = ADP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18705", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.287", "l": "\"D-arabinitol dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17341", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753634", "l": "GGT dimers hydrolyse APAP-SG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66260", "l": "CoA + IC-asc-C7-AMP = AMP + H(+) + IC-asc-C7-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59799", "l": "dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] <=> CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0045543", "l": "gibberellin 2-beta-dioxygenase activity", "d": ["Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 2-beta-hydroxygibberellin + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2995334", "l": "COX15 transforms heme O to heme A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102177", "l": "24-methylenelophenol methyl oxidase activity", "d": ["Catalysis of the reaction: 24-methylenelophenol + O2 + NADH + H+ = 4alpha-hydroxymethyl-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57824", "l": "dAMP + H2O = 2-deoxy-D-ribose 5-phosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375395", "l": "C5a receptor binds C5a anaphylatoxin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114558", "l": "Thrombin-activated PARs activate Gq (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30286", "l": "(-)-trans-permethrin + H2O <=> (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + (3-phenoxyphenyl)methanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65802", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine => a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21141", "l": "ATP + inosine => ADP + H(+) + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13976", "l": "diphosphate + H(+)(in) + H2O <=> 2 H(+)(out) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75891", "l": "Abortive Initiation After Second Transition (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27358", "l": "iodide + S-adenosyl-L-methionine => iodomethane + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0042166", "l": "acetylcholine binding", "d": ["Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14042", "l": "(R)-vicianin + H2O => mandelonitrile + vicianose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67963", "l": "4-amino-L-phenylalanine + S-adenosyl-L-methionine <=> 4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029270", "l": "Recruitment of PLCgamma to membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339535", "l": "CPTP transports C1P from plasma membrane to Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.89", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627072", "l": "RHOQ binds GOPC:CFTR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49479", "l": "2 H2O + L-1-piperideine-6-carboxylate + NAD(+) <=> H(+) + L-2-aminoadipate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090632", "l": "N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + Neu5Gc = diphosphate + CMP-Neu5Gc."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58551", "l": "2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75167", "l": "CTP + NAD(+) = CDP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51968", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32705", "l": "8-hydroxycopalyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647978", "l": "pro-RAS proteins are farnesylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18213", "l": "alpha-D-glucose 1-phosphate + CTP + H(+) = CDP-D-glucose + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.33", "l": "\"glucose-1-phosphate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351455", "l": "Phosphorylation of NBS1 by ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2545253", "l": "Deacetylation of cohesin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61692", "l": "holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP = AMP + L-threonyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42843", "l": "acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH <=> 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28759", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose = alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.325", "l": "\"TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848023", "l": "Activated PTK6 binds STAP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44804", "l": "1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) = 2-demethylmenaquinol-9 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44741", "l": "27-O-demethylrifamycin SV + S-adenosyl-L-methionine => H(+) + rifamycin SV + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36254", "l": "(E)-ferulate + ATP + CoA <=> (E)-feruloyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169406", "l": "ISGylation of host proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39685", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+) => 3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54629", "l": "2-oxoglutarate + dodecanoyl-CoA + O2 => 2-hydroxydodecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700156", "l": "Active ALK dimer binds IRS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59159", "l": "ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322434", "l": "XIAP dissociates from ub-TLE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322427", "l": "Beta-catenin recruits CBP/p300 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3132759", "l": "TCN1 binds RCbl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41768", "l": "a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1a (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25055", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 => (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179421", "l": "Degradation of multiubiquitinated Nek2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032036", "l": "LTA4 translocates from neutrophil cytosol to platelet cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30983", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63443", "l": "(2R)-3-phosphoglycerate + GTP + H(+) <=> 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030570", "l": "pectate lyase activity", "d": ["Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672957", "l": "PP2A dephosphorylates KSR1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52070", "l": "(9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+) => 9-(9Z-hexadecenoyloxy)-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60246", "l": "2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3] => 2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953037", "l": "E2F8 forms homodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174157", "l": "Degradation of multiubiquitinated Cyclin B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27609", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9842660", "l": "LTK binds ALKAL ligand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24809", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9906042", "l": "TTC19 clears UQCRFS1 fragments from Complex III (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50913", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol => 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62218", "l": "H(+) + NADPH + phyllostine => isoepoxydon + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696271", "l": "RND1 binds effectors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514790", "l": "Elastin degradation by MMP14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.17", "l": "\"benzylmalonyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392834", "l": "Activation of EPACs by cAMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004769", "l": "steroid delta-isomerase activity", "d": ["Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66755", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O <=> (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804266", "l": "CHEK2 phosphorylates TTC5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035923", "l": "flurbiprofen binding", "d": ["Binding to flurbiprofen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63046", "l": "H(+) + mevinic carboxylate => H2O + mevastatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57172", "l": "(S)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76083", "l": "(11R)-carlactone + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-19-hydroxycarlactone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38784", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52260", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide c = a bacteriochlorophyllide e + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160107", "l": "tRNA (adenine(58)-N1)-methyltransferase activity", "d": ["Catalysis of the reaction: adenosine(58) in tRNA + S-adenosyl-L-methionine = H+ + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52034", "l": "(+)-7-isojasmonate + L-isoleucine => H2O + L-isoleucine-(+)-7-isojasmonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61082", "l": "(+)-echitovenine + CoA => (+)-minovincinine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29355", "l": "dUMP + H2O = 2'-deoxyuridine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20285", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate = alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine", "d": [], "t": []}, {"i": "EC:2.4.1.211", "l": "\"1,3-beta-galactosyl-N-acetylhexosamine phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250217", "l": "ARL2:GTP binds ARL2BP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865182", "l": "OTUD7A hydrolyses K11diUb (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211224", "l": "Association of DFF40 with DFF45 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76901", "l": "cyclohexanone + H(+) + NADPH + NH4(+) => cyclohexylamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788611", "l": "HYKK phosphorylates 5HLYS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49425", "l": "ATP + validone => ADP + H(+) + validone 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11364", "l": "ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate", "d": [], "t": []}, {"i": "EC:2.7.9.2", "l": "\"pyruvate, water dikinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350651", "l": "Caspase-mediated cleavage of MASK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659380", "l": "Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8960973", "l": "RLBP1:11cRAL dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11168", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) = 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.259", "l": "\"3-hydroxypimeloyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.698016197404442", "identifiers": [{"i": "GO:0035251", "l": "UDP-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule."], "t": []}, {"i": "REACT:R-HSA-1912353", "l": "Glucosylation of Pre-NOTCH by POGLUT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483170", "l": "PS transports from the ER membrane to the IM membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65568", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2299620", "l": "Collagen XI cross-links with collagen II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222738", "l": "Carboxymycobactin gets secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641205", "l": "RSPO:LGR binds ZNRF3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875817", "l": "MET phosphorylates STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19093", "l": "2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2", "d": [], "t": []}, {"i": "EC:4.1.1.111", "l": "\"siroheme decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37991", "l": "delta-tocopherol + S-adenosyl-L-methionine = beta-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72691", "l": "Formation of the 43S pre-initiation complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59459", "l": "NADP(+) + tetradecan-1-ol <=> H(+) + NADPH + tetradecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65602", "l": "2 H(+) + jolkinol C + 2 NADH => 4,5,8-trihydroxycasbene + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48225", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside nLc4Cer(d18:1(4E)) + L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350388", "l": "ROK binds to activated RHO1:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75028", "l": "Phosphorylation of Wee1 kinase by Chk1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193646", "l": "NGF binding to p75NTR inactivates RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49185", "l": "chlorophyllide a + H(+) + H2O => 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010681", "l": "PKC phosphorylates ROBO3.1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427514", "l": "eNoSC deacetylates histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9704297", "l": "CHRM2 binds CHRM2 antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25807", "l": "H2O + O2 + spermine <=> 3-aminopropanal + H2O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49918", "l": "(R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75130", "l": "neopinone <=> codeinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25468", "l": "(2E,6E)-farnesyl diphosphate = beta-himachalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161282", "l": "Elastic fibres bind associated proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2314678", "l": "ASA- acetylates PTGS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396399", "l": "Fibrillins bind BMPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76384", "l": "carnosine(out) + n H(+)(out) => carnosine(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49025", "l": "L-tryptophan + O2 => 2-iminio-3-(indol-3-yl)propanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033930", "l": "keratan-sulfate endo-1,4-beta-galactosidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in keratan sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862184", "l": "USP48 cleaves polyubiquitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57320", "l": "acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] = CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936655", "l": "sulfite results from reduction of APS (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20450", "l": "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 => 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019194", "l": "sorbose transmembrane transporter activity", "d": ["Enables the transfer of sorbose from one side of a membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626816", "l": "PIN1 binds p-S345-NCF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71322", "l": "chloride(out) + L-cysteine(out) + 2 Na(+)(out) <=> chloride(in) + L-cysteine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45606", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) => D-glucaro-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57892", "l": "a quinone + 5 H(+)(in) + NADPH = a quinol + 4 H(+)(out) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018766", "l": "RHOU binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70666", "l": "4-hydroxy-L-proline(in) + H(+)(in) <=> 4-hydroxy-L-proline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031132", "l": "serine 3-dehydrogenase activity", "d": ["Catalysis of the reaction: L-serine + NADP+ = L-alpha-formylglycine + 2 H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952419", "l": "SMURFs ubiquitinate RUNX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70402", "l": "3-oxosphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167674", "l": "Binding of PLCG1 to active TrkA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9860168", "l": "MIR23B microRNA binds 3'UTR of TGFBR3 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388811", "l": "CD28 homodimer binds B7-1 homodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30926", "l": "(R)-glycerate + ADP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004379", "l": "glycylpeptide N-tetradecanoyltransferase activity", "d": ["Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29561", "l": "1-phospho-alpha-D-glucuronate + 2 H(+) + UMP => H2O + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033879", "l": "acetylajmaline esterase activity", "d": ["Catalysis of the reactions: 17-O-acetylajmaline + H2O = ajmaline + acetate, and 17-O-acetylnorajmaline + H2O = norajmaline + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047706", "l": "biochanin-A reductase activity", "d": ["Catalysis of the reaction: dihydrobiochanin A + NADP+ = biochanin A + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45257", "l": "hexadecanoate(out) => hexadecanoate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22802", "l": "obtusifoliol => cycloeucalenol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11887", "l": "3'-phosphoadenylyl sulfate + cortisol <=> adenosine 3',5'-bisphosphate + cortisol 21-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39082", "l": "(3S)-hydroxydodecanedioyl-CoA + NAD(+) <=> 3-oxododecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60461", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54515", "l": "peregrinol diphosphate <=> (13R)-9,13-epoxylabd-14-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033882", "l": "choloyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9690494", "l": "RHOB translocates to the endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64069", "l": "(R)-phenylacetylcarbinol + NAD(+) => 1-phenyl-1,2-propanedione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835385", "l": "DUS2 binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74740", "l": "Binding of SHC1 to insulin receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033715", "l": "nucleoside oxidase activity", "d": ["Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O; (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O, and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31251", "l": "(S)-3-hydroxyisobutanoyl-CoA + H2O = (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68447", "l": "5-cis-lycopene + O2 <=> (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11874", "l": "18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin] => corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17627", "l": "H(+) + L-lysine + NADPH + pyruvate => D-lysopine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731661", "l": "ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71395", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) = (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749253", "l": "Formation of MCM2-7 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59798", "l": "CoA + H(+) + N(6)-dodecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => dodecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20143", "l": "2-aminoprop-2-enoate + an S-alkyl sulfenate => an S-alkyl-L-cysteine S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3222237", "l": "SMYD2 methylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195251", "l": "Assembly of the destruction complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22913", "l": "L-valine + pyruvate => 3-methyl-2-oxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191402", "l": "Reduction of presqualene diphosphate to form squalene (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202291", "l": "Activation of Lck (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25887", "l": "carbamoyl phosphate + N(2)-succinyl-L-ornithine <=> H(+) + N(2)-succinyl-L-citrulline + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60814", "l": "CO2 + gibberellin A12 + H(+) + succinate => 2-oxoglutarate + gibberellin A12 aldehyde + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10046", "l": "cyclohexanone + H(+) + NADH => cyclohexanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090566", "l": "protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N,N'-diacetylchitobiose(out) = protein cysteine + N,N'-diacetylchitobiose phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39667", "l": "a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a ketone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}, {"i": "EC:1.1.98.5", "l": "\"secondary-alcohol dehydrogenase (coenzyme-F420)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51953", "l": "(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050067", "l": "lysine 2-monooxygenase activity", "d": ["Catalysis of the reaction: L-lysine + O2 = 5-aminopentanamide + CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683774", "l": "p-T68-CHEK2 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430096", "l": "GP1b-IX-V binds filamin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9834945", "l": "PINK1 phosphorylates Ub on MOM proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174551", "l": "Formation of alternative pathway C5 convertase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37246", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36569", "l": "GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH => GDP-beta-L-colitose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37482", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64183", "l": "an N-(fatty acyl)-L-tryptophan + H2O <=> a fatty acid + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32818", "l": "Hg(2+)(in) <=> Hg(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58419", "l": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350443", "l": "PP1-87B:MBS complex dephosphorylates SQH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43332", "l": "adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12299", "l": "H2O + N-deacetylipecoside <=> dopamine + secologanin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66671", "l": "5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68542", "l": "(-)-alpha-cedrene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9626817", "l": "PKC phosphorylates NCF1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052629", "l": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352268", "l": "Cleavage of Satb1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47042", "l": "5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein] => 5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17616", "l": "NAD(+) + scyllo-inositol <=> H(+) + NADH + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40096", "l": "26-oxohexacosanoate + H2O + NAD(+) => 2 H(+) + hexacosanedioate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24907", "l": "L-tyrosine => (E)-4-coumarate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57639", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate <=> holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23130", "l": "4-hydroxybutanoyl-CoA + AMP + diphosphate => 4-hydroxybutanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20707", "l": "a D-alpha-amino acid + acetyl-CoA <=> an N-acetyl-D-amino acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55231", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41419", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.327", "l": "\"aclacinomycin-T 2-deoxy-L-fucose transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49404", "l": "beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate = alpha-D-mannose 1-phosphate + D-mannose", "d": [], "t": []}, {"i": "EC:2.4.1.339", "l": "\"beta-1,2-mannobiose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53934", "l": "19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78331", "l": "UMP + UTP = 2 UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52846", "l": "1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP => 3,4-dihydroxybenzoate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017105", "l": "acyl-CoA delta11-(Z)-desaturase activity", "d": ["Catalysis of the reaction: an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (11Z)-delta-11-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58199", "l": "H2O + N(6)-acetyl-L-lysyl-[histone] <=> acetate + L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48236", "l": "2 2-acetylphloroglucinol = 1,3,5-trihydroxybenzene + 2,4-diacetylphloroglucinol + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.272", "l": "\"2-acetylphloroglucinol acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39209", "l": "(3R)-hydroxyhexacosanoyl-CoA + NADP(+) => 3-oxohexacosanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0061631", "l": "ubiquitin conjugating enzyme activity", "d": ["Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y = Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue."], "t": []}, {"i": "EC:2.3.2.23", "l": "\"E2 ubiquitin-conjugating enzyme\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008938", "l": "nicotinate N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26197", "l": "H2O + melamine = ammeline + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50043", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54614", "l": "2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylbutanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446634", "l": "IRAK4 is activated by autophosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50742", "l": "glycine + leukotriene F4 => H2O + leukotriene C4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13213", "l": "H2O + NADP(+) + succinate semialdehyde = 2 H(+) + NADPH + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54337", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429714", "l": "CSNK1G2 phosphorylates p-CERT1-2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018814", "l": "RHOT1 hydrolyzes GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917696", "l": "Cargo Sequestration (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59384", "l": "2-oxoglutarate + 4-amino-L-phenylalanine = 3-(4-aminophenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51949", "l": "(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61176", "l": "(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75654", "l": "(10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate <=> 12,13-epoxy-(10R)-hydroxy-(8E,15Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034915", "l": "2-methylhexanoyl-CoA C-acetyltransferase activity", "d": ["Catalysis of the reaction: 4-methyl-3-oxooctanoyl-CoA + CoA = acetyl-CoA + 2-methylhexanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65889", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625092", "l": "ABCA6 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15893", "l": "Co-sirohydrochlorin + 2 H(+) = Co(2+) + sirohydrochlorin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.3.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928656", "l": "gamma-secretase cleaves EPHB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36171", "l": "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)", "d": [], "t": []}, {"i": "EC:2.5.1.26", "l": "\"alkylglycerone-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19871", "l": "an N-acylglycine + CoA + H(+) => an acyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220971", "l": "CDK8 phosphorylates NICD1 PEST domain mutants  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784734", "l": "PCSK9 binds LDLR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55773", "l": "a jasmonate + an L-alpha-amino acid + ATP => a jasmonyl-L-amino acid + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61897", "l": "betaenone C => betaenone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62590", "l": "4-hydroxybenzyl alcohol + CO2 => 2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78680", "l": "Sr(2+)(in) => Sr(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48385", "l": "a 2,3-saturated fatty acid + H2O2 => a 3-hydroxy fatty acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61972", "l": "1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31876", "l": "(S)-2,3-epoxysqualene => marneral", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43934", "l": "androst-5-ene-3,17-dione + H(+) + NADH => 3beta-hydroxyandrost-5-en-17-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58664", "l": "(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol", "d": [], "t": []}, {"i": "EC:1.1.5.13", "l": "\"(S)-2-hydroxyglutarate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390886", "l": "HRH4 binds Hist (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951727", "l": "cAMP binds PKA tetramer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34899", "l": "malonyl-CoA + S-adenosyl-L-methionine = malonyl-CoA methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53478", "l": "(6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24083", "l": "ATP + L-tryptophan + tRNA(Trp) <=> AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69494", "l": "H2O2 + octanal => O2 + octan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618107", "l": "ATP binding to HSP90 triggers conformation change (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31783", "l": "H2O + tuberculosinyl diphosphate = diphosphate + tuberculosinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59071", "l": "demethyldeoxyspectinabilin + S-adenosyl-L-methionine <=> deoxyspectinabilin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827997", "l": "Expression of NANOG in primordial germ cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27771", "l": "3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78234", "l": "queuosine(34) in tRNA(Tyr) + UDP-alpha-D-galactose <=> H(+) + O-5''-beta-D-galactosylqueuosine(34) in tRNA(Tyr) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937343", "l": "NLRC5 interacts with DDX58/IFIH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64503", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine <=> 3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.273097872185119", "identifiers": [{"i": "GO:0005242", "l": "inward rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66204", "l": "heptanoyl-CoA + O2 = (2E)-heptenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448702", "l": "Caspase-1 active tetramer formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20272", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate <=> 2 5-dehydro-4-deoxy-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59168", "l": "ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate = AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32820", "l": "chromate(in) => chromate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961888", "l": "E2F1 binds the CCNA1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218836", "l": "PTK2beta binds alphaVbeta3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36631", "l": "D-ribulose 1,5-bisphosphate + O2 = (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22781", "l": "(9Z,12Z)-octadecadienoate + O2 => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67872", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose = 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74840", "l": "UDP(in) + UDP-alpha-D-glucuronate(out) => UDP(out) + UDP-alpha-D-glucuronate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983700", "l": "SYK binds the activated BCR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54301", "l": "n 3'-phosphoadenylyl sulfate + chondroitin 4'-sulfate => n adenosine 3',5'-bisphosphate + chondroitin 4',6'-bissulfate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68524", "l": "(2Z,6Z)-farnesyl diphosphate = beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35034", "l": "L-serine(in) <=> L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003838", "l": "sterol 24-C-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + zymosterol = fecosterol + H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17194", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30278", "l": "AH2 + H2O2 <=> A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13574", "l": "[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate => [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55470", "l": "11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64071", "l": "(R)-phenylacetylcarbinol + NAD(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43041", "l": "hexadecanoyl-CoA + hexadecasphinganine => CoA + H(+) + N-hexadecanoylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034571", "l": "4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity", "d": ["Catalysis of the reaction: 4'-(2-hydroxyisopropyl)phenylurea + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + carbamic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3858475", "l": "ppDVL recruits RAC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353243", "l": "Monoubiquitunated PCNA mediates recruitment of the translesion polymerase to the DNA damaged site. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23932", "l": "an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102977", "l": "nitrilotriacetate monooxygenase activity (FMN-dependent)", "d": ["Catalysis of the reaction: nitrilotriacetate + O2 + FMNH2 = ammoniodiacetate + 2-oxo monocarboxylic acid anion + H2O + FMN."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63904", "l": "2 3-phenylpyruvate + H(+) = H2O + phenguignardate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65244", "l": "(2S)-hesperetin + UDP-alpha-D-glucose = (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043836", "l": "xanthine hydrolase activity", "d": ["Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61966", "l": "a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66091", "l": "L-kynurenine + oxaloacetate <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14631", "l": "ADP + N-acetyl-L-glutamyl 5-phosphate => ATP + N-acetyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008043", "l": "MAPK8 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.13", "l": "\"RNA helicase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69696", "l": "H(+) + menadione + NADH => menadiol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38232", "l": "(9Z)-hexadecen-1-ol + (9Z)-octadecenoyl-CoA => 1-O-(9Z)-hexadecenyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14729", "l": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": [], "t": []}, {"i": "EC:4.1.2.13", "l": "\"fructose-bisphosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30919", "l": "A + rhodopin = (3E)-3,4-didehydrorhodopin + AH2", "d": [], "t": []}, {"i": "EC:1.3.99.27", "l": "\"1-hydroxycarotenoid 3,4-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620837", "l": "CCNG2 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68860", "l": "7-oxo-25-hydroxycholesterol + H(+) + NADPH = 7beta-25-dihydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27470", "l": "H2O + N,N'-diacetylchitobiose => acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71670", "l": "PKM dephosphorylates PEP to PYR (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53617", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-isoafricanol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52187", "l": "(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008510", "l": "sodium:bicarbonate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953339", "l": "DNPH1 hydrolyses dGMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50201", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17020", "l": "acetyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] <=> CoA + N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28638", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-5-epi-aristolochene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0050497", "l": "alkylthioltransferase activity", "d": ["Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.8.4.-", "l": "\"Transferring alkylthio groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694428", "l": "LMAN family proteins bind glycosylated cargo (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11708", "l": "H2O + IMP + NAD(+) = H(+) + NADH + XMP", "d": [], "t": []}, {"i": "EC:1.1.1.205", "l": "\"IMP dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28567", "l": "3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP => 6 AMP + enterobactin + 7 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614614", "l": "Cysteine is degraded to serine and H2S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756150", "l": "PON1,3 hydrolyse 4-OH-ATVL to 4-OH-ATV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42949", "l": "cytidine(48) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182279", "l": "Formation of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12601", "l": "2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.39", "l": "\"2-aminoadipate transaminase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37744", "l": "dimethylallyl phosphate + FMNH2 => phosphate + prenyl-FMNH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69845", "l": "a uridine in RNA + H(+) + NADH => a 5,6-dihydrouridine in RNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019149", "l": "3-chloro-D-alanine dehydrochlorinase activity", "d": ["Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804955", "l": "ATM phosphorylates MDM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674531", "l": "AAMP binds EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097030", "l": "CENP-A containing nucleosome binding", "d": ["Binding to a centromere-specific nucleosome, a form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0003997", "l": "acyl-CoA oxidase activity", "d": ["Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16595", "l": "3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112510", "l": "IL6ST is tyrosine phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25010", "l": "N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9823065", "l": "GPIb:IX:V binds to VWF multimer:collagen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.34", "l": "\"cathepsin E\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47288", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18582", "l": "ethanolamine + H2O + O2 => glycolaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62539", "l": "digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+) <=> dihydrodigoxigenin + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693783", "l": "NAALADases hydrolyse NAAG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57200", "l": "glyoxal + L-arginyl-[protein] = N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030943", "l": "mitochondrion targeting sequence binding", "d": ["Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201611", "l": "Caspase-mediated cleavage of Rock-1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11066", "l": "beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 1,6-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72070", "l": "(2S)-2-aminobutanoate + ATP + L-glutamate <=> ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810643", "l": "EPPIN protein complex binds bacteria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748996", "l": "GST dimers cleave AZA to 6MP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23887", "l": "nicotinamide + S-adenosyl-L-methionine <=> 1-methylnicotinamide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24060", "l": "N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090079", "l": "GLB1 hydrolyses linker chain(2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102753", "l": "chlorophyllide b:geranyl-geranyl diphosphate geranyl-geranyltransferase activity", "d": ["Catalysis of the reaction: H+ + chlorophyllide b(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate = geranylgeranyl-chlorophyll b + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39690", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA <=> (2E,11Z)-octadecadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34048", "l": "6'''-deamino-6'''-hydroxyneomycin C + O2 => 6'''-deamino-6'''-oxoneomycin C + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60515", "l": "a guanosine in miRNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in miRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28263", "l": "3-alpha-D-mannopyranosyl-alpha-D-mannopyranose + UDP-alpha-D-xylose => 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64558", "l": "8-epi-ilicicolin H => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62297", "l": "(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) => (+)-malbrancheamide + 2 FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.354970481220079", "identifiers": [{"i": "GO:0016783", "l": "sulfurtransferase activity", "d": ["Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5622134", "l": "CRABP1 binds atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634834", "l": "ACHEIs bind ACHE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59757", "l": "L-arginine + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2529020", "l": "CK2 phosphorylates condensin I subunits (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.368900840266221", "identifiers": [{"i": "GO:0000166", "l": "nucleotide binding", "d": ["Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25304", "l": "7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+) => 7,8-dihydroneopterin 3'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.19", "l": "\"(R)-specific secondary-alkylsulfatase (type III)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78503", "l": "2-oxoglutarate + 3-(N-acetyl-N-hydroxy)aminopropylphosphonate + O2 = (R)-(3-(acetylhydroxyamino)-2-hydroxypropyl)phosphonate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015532", "l": "alpha-ketoglutarate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76573", "l": "(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate => 4-deoxy-L-erythro-hex-4-enopyranuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417820", "l": "P2Y9 receptor can bind to LPA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47964", "l": "H2O + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54543", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] <=> beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67141", "l": "L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 => H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69020", "l": "L-aspartate + NADPH + O2 = H2O + N-hydroxy-L-aspartate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41849", "l": "(2E)-octenoyl-[ACP] + H(+) + NADPH => NADP(+) + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750666", "l": "ALB binds ST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65436", "l": "a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) = a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.88", "l": "\"GDP polyribonucleotidyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956684", "l": "ITCH polyubiquitinates TP73 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638156", "l": "RBFOX3 (NeuN) gene expression is stimulated by NPAS4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009044", "l": "xylan 1,4-beta-xylosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70983", "l": "glycine(out) + n H(+)(in) = glycine(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019992", "l": "diacylglycerol binding", "d": ["Binding to a diacylglycerol, a diester of glycerol and two fatty acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247511", "l": "STAB2:ligand is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706356", "l": "CBL mutants don't ubiquitinate FLT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70857", "l": "L-glutamine(in) + L-serine(out) + Na(+)(in) => L-glutamine(out) + L-serine(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83677", "l": "C4 deamination of cytidine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9626928", "l": "CREBBP binds FOXO1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0004353", "l": "glutamate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34044", "l": "5-phospho-alpha-D-ribose 1-diphosphate + neamine => 5''-phosphoribostamycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19303", "l": "H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine => histamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83788", "l": "Binding of TFIIIC to Type 2 promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38259", "l": "(2R,3S)-beta-methylmalyl-CoA = glyoxylate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15817", "l": "H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2317314", "l": "AKT binds PDPK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690740", "l": "CD22 binds B-cell receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.117", "l": "\"hydroxycinnamoyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71739", "l": "2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106309", "l": "progesterone 21-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}, {"i": "RHEA:50304", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53440", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517674", "l": "p-S158,221-HuR binds mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018816", "l": "2-hydroxyisobutyrate dehydratase activity", "d": ["Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62748", "l": "H2O + lovastatin = (S)-2-methylbutanoate + H(+) + monacolin J", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69706", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O <=> beta-D-galactose + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66604", "l": "a 2'-deoxycytidine in double-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in double-stranded DNA + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.101", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29204", "l": "dimethyl sulfoxide + menaquinol-8 => dimethyl sulfide + H2O + menaquinone-8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18486", "l": "6-acetyl-D-glucose + H2O => acetate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60089", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) => a 4alpha-methyl-3-oxosteroid + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32395", "l": "(1S,2S,4S)-dihydrocarveol + NAD(+) = (1S,4S)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.185", "l": "\"L-glycol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11584", "l": "L-ornithine = D-ornithine", "d": [], "t": []}, {"i": "EC:5.1.1.12", "l": "\"ornithine racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49456", "l": "(2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate", "d": [], "t": []}, {"i": "EC:3.3.2.15", "l": "\"trans-2,3-dihydro-3-hydroxyanthranilic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047677", "l": "arachidonate 8(R)-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8R,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64456", "l": "L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.372", "l": "\"[histone H4]-lysine(20) N-trimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75452", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202724", "l": "P-selectin binds P-selectin ligand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39318", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA <=> (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.21", "l": "\"L-carnitine CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43603", "l": "3-oxoeicosanoyl-[ACP] + H(+) + NADPH <=> 3R-hydroxyeicosanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9676264", "l": "Formation of the SET1B complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74899", "l": "(2E)-2-butenoate + ATP + holo-[ACP] = (2E)-butenoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39655", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2 = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37547", "l": "D-glucose 6-phosphate + NAD(+) = 3-dehydro-D-glucose 6-phosphate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.361", "l": "\"glucose-6-phosphate 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.2", "l": "\"exoribonuclease H\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936380", "l": "Interaction of PIN1 with p-IRF3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196964", "l": "RFK:Mg2+ phosphorylates RIB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65669", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58125", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31077", "l": "(2E)-dodecenoyl-CoA + H2O => (3S)-3-hydroxydodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64712", "l": "1-propanol + NADP(+) = H(+) + NADPH + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73406", "l": "(2R,3R)-tartrate(in) + sulfate(out) <=> (2R,3R)-tartrate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44881", "l": "ATP + L-threonyl-[receptor-protein] => ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69173", "l": "Joining of adjacent Okazaki fragments (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68711", "l": "(2E)-geranyl diphosphate + H2O <=> diphosphate + linalool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905172", "l": "RISC complex binding", "d": ["Binding to a RISC complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22181", "l": "(S)-norreticuline + S-adenosyl-L-methionine => (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59878", "l": "(indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+) => (indol-3-yl)butanoate + ATP + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26075", "l": "D-glucuronate + H(+) + UDP => H2O + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33386", "l": "(S)-malate + UDP-N-acetyl-alpha-D-glucosamine <=> (S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.12.1.-", "l": "\"Acting on sulfur-sulfur bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043828", "l": "tRNA 2-selenouridine synthase activity", "d": ["Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.33584335509623", "identifiers": [{"i": "GO:0004402", "l": "histone acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9716947", "l": "ESR1 binds ESR1 agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.110", "l": "\"C5a peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44547", "l": "a fatty acid(out) + ATP + H2O <=> a fatty acid(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837354", "l": "NUDT8 hydrolyzes CoA-SH to PPANT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59613", "l": "beta-alanyl-L-ornithine + H2O => beta-alanine + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27889", "l": "2',3'-cyclophospho-AMP + H2O <=> 3'-AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63844", "l": "[thioredoxin]-dithiol + cumene hydroperoxide = 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373705", "l": "Caspase cleavage of DCC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34790", "l": "a 3beta-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62048", "l": "an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36354", "l": "AH2 + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-methionine <=> 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0000384", "l": "first spliceosomal transesterification activity", "d": ["Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59112", "l": "ATP + L-serine = ADP + H(+) + O-phospho-L-serine", "d": [], "t": []}, {"i": "EC:2.7.1.225", "l": "\"L-serine kinase (ATP)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62723", "l": "3 H(+) + 3 NADPH + 3 O2 + probetaenone I <=> betaenone B + 3 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65530", "l": "CoA + hexyl octanoate => hexan-1-ol + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14016", "l": "3'-phosphoadenylyl sulfate + taurolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63124", "l": "H2O + N-octadecanoyl ethanolamine = ethanolamine + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15977", "l": "(S)-4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrogen cyanide", "d": [], "t": []}, {"i": "EC:4.1.2.11", "l": "\"hydroxymandelonitrile lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72663", "l": "De novo formation of eIF2:GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047415", "l": "D-benzoylarginine-4-nitroanilide amidase activity", "d": ["Catalysis of the reaction: N(2)-benzoyl-D-arginine-4-nitroanilide + H2O = 4-nitroaniline + N(2)-benzoyl-D-arginine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2317332", "l": "PIP3 recruits AKT to the membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66244", "l": "ATP + H(+) + IC-asc-C9 = diphosphate + IC-asc-C9-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35108", "l": "3-nitrotyramine + H2O + O2 => 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45136", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate = 7,8-dihydroneopterin 3'-phosphate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.160", "l": "\"2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31406", "l": "all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) <=> all-trans-4,4'-diaponeurosporene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54689", "l": "alliin => 2-aminoprop-2-enoate + allylsulfenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035870", "l": "dITP diphosphatase activity", "d": ["Catalysis of the reaction: dITP + H2O = dIMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38168", "l": "hexadecan-1-ol + hexadecanoyl-CoA => CoA + hexadecanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10116", "l": "6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63979", "l": "A + dihydropyriculariol <=> AH2 + pyriculariol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090353", "l": "polygalacturonase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of polygalacturonase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45178", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65574", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430311", "l": "Rsu-1 interacts with Pinch1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74032", "l": "L-alanine(in) + L-cysteine(out) => L-alanine(out) + L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29405", "l": "3-demethylubiquinol-8 + A + H2O => 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984001", "l": "IL35 binds IL27RA:IL12RB2 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36386", "l": "carbamoyl adenylate + tobramycin <=> AMP + H(+) + nebramycin 5'", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39147", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + CoA = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265887", "l": "Binding of RPA heterotrimer to 3' double stranded DNA break (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36888", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976768", "l": "Factor H binds to C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110380", "l": "Dissociation of LIG3:XRCC1 complex from the BER site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791180", "l": "Expression of IGFBP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18646", "l": "2 putrescine => NH4(+) + sym-homospermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373716", "l": "DCC interacting NCK-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015594", "l": "ABC-type putrescine transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + putrescine(out) -> ADP + phosphate + putrescine(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55167", "l": "a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 <=> H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72910", "l": "D-mannose(out) + Na(+)(out) <=> D-mannose(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43450", "l": "(2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14132", "l": "cholate + NADP(+) <=> 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76918", "l": "(1S)-3-methyl-cyclohexylamine + H2O + NADP(+) <=> 3-methylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43754", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5] => acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36287", "l": "H(+) + NADPH + O2 + theobromine = 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49097", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine => 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29099", "l": "a menaquinone + 5 H(+)(in) + NADH = a menaquinol + 4 H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018445", "l": "prothoracicotrophic hormone activity", "d": ["The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56235", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O <=> [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003746", "l": "translation elongation factor activity", "d": ["Functions in chain elongation during polypeptide synthesis at the ribosome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190245", "l": "FGFR1b binds to FGF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507870", "l": "Aquaporins passively transport water out of cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823354", "l": "Protein N forms hendecamers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62027", "l": "campesteryl 3-beta-D-glucoside + H2O <=> campesterol + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10487", "l": "H2O + N-feruloylglycine <=> (E)-ferulate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49384", "l": "(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70289", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 3,4,6-trisphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67769", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17665", "l": "L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]", "d": [], "t": []}, {"i": "EC:2.3.1.181", "l": "\"lipoyl(octanoyl) transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38965", "l": "ADP + H(+) + leukotriene C4(out) + phosphate => ATP + H2O + leukotriene C4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395439", "l": "Phosphorylation of DAP12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3209165", "l": "ID1 sequesters ETS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63880", "l": "2 Fe(III)-[cytochrome c] + H2O + thiocyanate = cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur", "d": [], "t": []}, {"i": "EC:1.8.2.7", "l": "\"thiocyanate desulfurase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426162", "l": "SREBP1A,2 binds the HMGCR promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140339", "l": "phosphatidylglycerol transfer activity", "d": ["Directly binding to phosphatidylglycerol and delivering it either to an acceptor molecule or to a specific location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5334794", "l": "FABPs bind LCFAs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47667", "l": "H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) <=> 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10948", "l": "ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113413", "l": "TFIIS-mediated recovery of elongation from arrest (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39874", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 3-acyl-sn-glycerol <=> a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031760", "l": "Edg-7 lysophosphatidic acid receptor binding", "d": ["Binding to an Edg-7 lysophosphatidic acid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32283", "l": "3-hydroxyanthranilate + O2 = H(+) + H2O + quinolinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66839", "l": "4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase] <=> asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9010872", "l": "SLIT2 binds Dystroglycan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158399", "l": "kallikrein binds SERPING1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68778", "l": "diphosphate + germacrene A => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102890", "l": "naringenin chalcone 4'-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 2',4,4',6'-tetrahydroxychalcone = UDP + 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956639", "l": "RUNX1 binds YAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917841", "l": "Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44092", "l": "ATP + CoA + nonadecanoate = AMP + diphosphate + nonadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052829", "l": "inositol-1,3,4-trisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate."], "t": []}, {"i": "REACT:R-HSA-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43881", "l": "(25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA => (25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419428", "l": "S1PR2-5 bind S1P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71681", "l": "H(+)(in) + L-lysyl-glycine(in) => H(+)(out) + L-lysyl-glycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018584", "l": "2,4,5-trichlorophenoxyacetic acid oxygenase activity", "d": ["Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49173", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850777", "l": "SPINK6 binds KLK14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863727", "l": "STON2 is neddylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050130", "l": "N-methyl-2-oxoglutaramate hydrolase activity", "d": ["Catalysis of the reaction: N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylammonium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26415", "l": "a secondary aliphatic amine + H2O + O2 => a primary amine + an aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42888", "l": "(R)-3-phosphomevalonate + ATP = (R)-3,5-bisphosphomevalonate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.186", "l": "\"mevalonate-3-phosphate 5-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11717", "l": "a monoamide of a dicarboxylate + H2O => a dicarboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296326", "l": "HCAR1 binds LACT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75916", "l": "H2O + NAD(+) + serinol => dihydroxyacetone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.3", "l": "\"glutamate dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11044", "l": "a haloacetate + H2O = a halide anion + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047739", "l": "cephalosporin-C deacetylase activity", "d": ["Catalysis of the reaction: cephalosporin C + H2O = acetate + deacetylcephalosporin C + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16101", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.5", "l": "\"chondroitin 4-sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76564", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acylsphing-14Z-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27639", "l": "phosphate + xanthosine => alpha-D-ribose 1-phosphate + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62273", "l": "4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222128", "l": "NOC2L binds TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11826", "l": "(6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12185", "l": "(S,S)-butane-2,3-diol + NAD(+) => (S)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9663511", "l": "BIL binds GSTA1, FABP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25464", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + longifolene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76694", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione <=> (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60160", "l": "ATP + H2O + vincristine(in) = ADP + H(+) + phosphate + vincristine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050325", "l": "tauropine dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + tauropine = H+ + NADH + pyruvate + taurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58418", "l": "(E)-4-hydroxynon-2-enal + H(+) + NADPH => (E)-4-hydroxynon-2-en-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47308", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16736", "l": "H(+) + orsellinate <=> CO2 + orcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5674018", "l": "BRAP binds RAS:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66852", "l": "(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43359", "l": "cholesteryl (9Z,12Z)-octadecadienoate(in) <=> cholesteryl (9Z,12Z)-octadecadienoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38357", "l": "(E)-cinnamoyl-CoA + H2O => (R)-3-phenyllactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001851", "l": "complement component C3b binding", "d": ["Binding to a C3b product of the complement cascade."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20741", "l": "H2O + trans-2,3-epoxysuccinate => (2R,3S)-tartrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140806", "l": "NAD+- protein-aspartate ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56913", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) => (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12114", "l": "(R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + S-adenosyl-L-homocysteine => indole-3-pyruvate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5674385", "l": "p-T,Y MAPKs dimerize (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38883", "l": "a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676264", "l": "Formation of the SET1B complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41630", "l": "cyclooctat-9-en-7-ol + diphosphate => geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0050524", "l": "coenzyme-B sulfoethylthiotransferase activity", "d": ["Catalysis of the reaction: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane. Methyl-CoM is also known as 2-(methylthio)ethanesulfonate, coenzyme B as N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, and coenzyme M-coenzyme B heterodisulfide as CoM-S-S-CoB."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299297", "l": "Activation of THIK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14475", "l": "a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH => a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202203", "l": "Recruitment of PI3K to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218824", "l": "p-6Y-VEGFR2 binds FYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050228", "l": "pterin deaminase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33008", "l": "(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70481", "l": "TPI1 isomerizes GA3P to DHAP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46643", "l": "7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH <=> 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0016721", "l": "oxidoreductase activity, acting on superoxide radicals as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.15.-.-", "l": "\"Acting on superoxide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73839", "l": "ATP + H2O + phenol = AMP + 2 H(+) + phenyl phosphate + phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.238", "l": "\"phenol phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71177", "l": "2 chloride(in) + glycine betaine(in) + 3 Na(+)(in) => 2 chloride(out) + glycine betaine(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8873929", "l": "Casein kinase II phosphorylates STARD10 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-217255", "l": "FMO1:FAD N-oxidises TAM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46916", "l": "H2O + juvenile hormone I = H(+) + juvenile hormone I carboxylate + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050186", "l": "phosphoadenylylsulfatase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22603", "l": "H2O + N-acetyl-9-O-acetylneuraminate <=> acetate + H(+) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201521", "l": "ALK autophosphorylation  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428609", "l": "Type I Na+-coupled phosphate co-transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730882", "l": "Phosphorylation of PKC-theta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854209", "l": "TBC1D10A binds JFC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68610", "l": "Formation of ORC(2-5) complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57680", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.76", "l": "\"flavone synthase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163090", "l": "Elongation Of The Telomeric Chromosome End (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51999", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55212", "l": "(2R)-hydroxyhexadecanoyl-CoA = formyl-CoA + pentadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22779", "l": "2 H(+) + H2O2 + 2 Mn(2+) <=> 2 H2O + 2 Mn(3+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77271", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.1", "l": "\"dihydrouracil dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27865", "l": "3'-GMP + H2O <=> guanosine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35500", "l": "11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23363", "l": "L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose <=> alpha-D-glucosyl-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.16", "l": "\"ABC-type ferric hydroxamate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621406", "l": "EGR2 and SREBF2 dimer bind CYP51A1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601976", "l": "Defective CYP21A2 does not 21-hydroxylate PROG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50390", "l": "5a,11a-dehydrooxytetracycline + H2O + NADP(+) => 5a,11a-dehydrotetracycline + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.26", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.36", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64379", "l": "8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid <=> a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50103", "l": "dodecanoyl-CoA + taurine <=> CoA + H(+) + N-dodecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37675", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.42", "l": "\"D-threonine aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71830", "l": "arsenate(in) + H(+)(in) <=> arsenate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15102", "l": "H(+) + meso-2,6-diaminoheptanedioate => CO2 + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30065", "l": "H(+) + menaquinol-8 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-8 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084912", "l": "Arresten binds integrin alpha1beta1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013438", "l": "RHOD binds effectors at the endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2993802", "l": "HLCS biotinylates PC:Mn2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28562", "l": "D-alanine + pyridoxal 5'-phosphate = pyridoxamine 5'-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004176", "l": "ATP-dependent peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11062", "l": "AMP + diphosphate + L-isoleucyl-tRNA(Ile) => ATP + L-isoleucine + tRNA(Ile)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847968", "l": "PTEN binds FRK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617661", "l": "MAFB:JUN and EGR2 activate HOXB3 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25787", "l": "2-dehydro-3-deoxy-L-rhamnonate <=> (S)-lactaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029453", "l": "Phosphorylation of VAV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23598", "l": "3 H(+) + 2 NADH + UDP-alpha-D-glucuronate => H2O + 2 NAD(+) + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102955", "l": "S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity", "d": ["Catalysis of the reaction: 2-demethylmenaquinol-7 + S-adenosyl-L-methionine = menaquinol-7 + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44676", "l": "a triacylglycerol + all-trans-retinol = a diacylglycerol + an all-trans-retinyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31187", "l": "(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433488", "l": "Phosphorylation of SHP2 by SFKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70663", "l": "4-hydroxy-L-proline(in) + H(+)(in) = 4-hydroxy-L-proline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061708", "l": "tRNA-5-taurinomethyluridine 2-sulfurtransferase", "d": ["Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433456", "l": "Recruitment of STATs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004420", "l": "hydroxymethylglutaryl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3134946", "l": "DDX41 ubiquitination by TRIM21 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380780", "l": "Activation of Src (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47051", "l": "a quinone + shikimate <=> 3-dehydroshikimate + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12684", "l": "creatinine + H(+) + H2O <=> N-methylhydantoin + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41861", "l": "(3R)-hydroxydecanoyl-[ACP] => (2E)-decenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29781", "l": "ADP + H(+) + L-methionine(in) + phosphate => ATP + H2O + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41746", "l": "a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853801", "l": "PSPN binds RET:GFRA4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55345", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol => 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75900", "l": "1,2-diacyl-sn-glycero-3-phospho-N-acyl-L-serine + H2O => 1-acyl-sn-glycero-3-phospho-N-acyl-L-serine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36915", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63156", "l": "H2O + N-docosanoyl-taurine = docosanoate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58117", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose => 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67834", "l": "CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27486", "l": "allantoate + 2 H(+) + H2O => (S)-2-ureidoglycine + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34515", "l": "tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine = N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.36", "l": "\"undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264834", "l": "Endocytosis and degradation of apoA-I (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008426", "l": "protein kinase C inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654404", "l": "Activated FGFR2 binds SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9825754", "l": "HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43899", "l": "3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54940", "l": "(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2423785", "l": "CR:atREs binds apoE and HSPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050537", "l": "mandelamide amidase activity", "d": ["Catalysis of the reaction: (R)-mandelamide + H2O = (R)-mandelate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3318415", "l": "ATF2 acetylates histone H2B, H4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696268", "l": "RND3 binds effectors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75623", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate = 14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170964", "l": "FRS2 binds to active TrkA receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031531", "l": "thyrotropin-releasing hormone receptor binding", "d": ["Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47544", "l": "trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31504", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate => 4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211206", "l": "Translocation of DFF to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9611839", "l": "β3-agonists bind ADRB3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9706837", "l": "AR binds AR antagonists (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70719", "l": "L-alanine(in) = L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55270", "l": "(R)-glycerate + alpha-D-glucose 1-phosphate => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419334", "l": "Melatonin receptors can bind melatonin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18208", "l": "AH2 + O2 + progesterone <=> 11alpha-hydroxyprogesterone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033949", "l": "fructan beta-(2,6)-fructosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing (2->6) linked beta-D-fructofuranose residues in fructans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050207", "l": "plasmanylethanolamine desaturase activity", "d": ["Catalysis of the reaction:1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052912", "l": "23S rRNA (guanine(748)-N(1))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanine(748) in 23S rRNA = N(1)-methylguanine(748) in 23S rRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5606996", "l": "Soluble PROCR binds activated protein C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21321", "l": "A + D-sorbitol => AH2 + keto-L-sorbose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.3", "l": "\"NAD(P)(+) transhydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022728", "l": "FKBP5 gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49895", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 <=> (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.6", "l": "\"pyroglutamyl-peptidase II\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.14", "l": "\"actinidain\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36475", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16794", "l": "H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantetheine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20061", "l": "2'-deoxycytidine + a ribonucleoside 5'-triphosphate = a ribonucleoside 5'-diphosphate + dCMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66890", "l": "8-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67125", "l": "a hydroperoxide + L-cysteinyl-[protein] => an alcohol + S-hydroxy-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390035", "l": "HPO dimer autophosphorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61860", "l": "dehydroprobetaenone I + H(+) + NADPH + O2 = epoxybetaenone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73146", "l": "CoA(out) + FAD(in) <=> CoA(in) + FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77868", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-leucine + O2 => 2-dehydro-D-glucose + H2O2 + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32327", "l": "10-hydroxy-alpha-humulene + NAD(+) = H(+) + NADH + zerumbone", "d": [], "t": []}, {"i": "EC:1.1.1.326", "l": "\"zerumbone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23332", "l": "(2R)-3-phosphoglycerate + GTP = (2R)-3-phospho-glyceroyl phosphate + GDP", "d": [], "t": []}, {"i": "EC:2.7.2.10", "l": "\"phosphoglycerate kinase (GTP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74111", "l": "H(+) + hypotaurine + NADH + O2 = H2O + NAD(+) + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851919", "l": "Activated MET binds GAB1 and GRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63055", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840795", "l": "Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34444", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose => CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0015377", "l": "chloride:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)."], "t": []}, {"i": "TCDB:2.A.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134953", "l": "DHX36 or DHX9 binds MyD88 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38364", "l": "1-octadecanoylglycerol + H2O => glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48231", "l": "a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] <=> a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49072", "l": "dibenzothiophene + 2 FMNH2 + 2 O2 = dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.14.21", "l": "\"dibenzothiophene monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28041", "l": "[thioredoxin]-disulfide + dCDP + H2O <=> [thioredoxin]-dithiol + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76223", "l": "3',5'-cyclic AMP(in) = 3',5'-cyclic AMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61445", "l": "a tetracycline + H(+) + NADPH + O2 => an 11a-hydroxytetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49775", "l": "glycine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390663", "l": "ADRA2A,B,C bind ADR,NAd (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062239", "l": "heterochromatin-nuclear membrane anchor activity", "d": ["Binding to heterochromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45921", "l": "16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16178", "l": "H2O + NAD(+) + retinal => 2 H(+) + NADH + retinoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012016", "l": "FAHD1 dimer hydrolyses OA to PYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58886", "l": "A + chloramphenicol + 2 H2O => AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61568", "l": "an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51758", "l": "a 2-acyl-4,6-diprenylphloroglucinol + diphosphate => a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17310", "l": "a phenyl acetate + H2O => a phenol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33242", "l": "L-threonine + NAD(+) <=> aminoacetone + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097682", "l": "intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity", "d": ["Enables the transmembrane transfer of cations by a channel that opens when phosphatidylinositol-3,5-bisphosphate has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78043", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-3-acylglycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12092", "l": "(S)-acetoin = (R)-acetoin", "d": [], "t": []}, {"i": "EC:5.1.2.4", "l": "\"acetoin racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186798", "l": "GAP binds to PDGF-beta receptors only (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849428", "l": "PTPN1 binds PTK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65330", "l": "AH2 + chrodrimanin H => A + chrodrimanin F", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080132", "l": "fatty acid alpha-hydroxylase activity", "d": ["Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain."], "t": []}, {"i": "REACT:R-HSA-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25442", "l": "delta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23386", "l": "beta-D-glucosyl-(1->4)-D-mannopyranose => D-cellobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61239", "l": "H2O + L-methionine + O2 <=> 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793666", "l": "MDM2 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72296", "l": "malate(out) + 3 Na(+)(out) => malate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78991", "l": "a 4-carboxy-3-alkylbut-(2E)-enoyl-[ACP] + H(+) = a 3-alkylbut-(2E)-enoyl-[ACP] + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.125", "l": "\"4-carboxy-3-alkylbut-2-enoyl-[ACP] decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53006", "l": "2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210285", "l": "Trans-homophilic interaction of PECAM-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70994", "l": "SDH complex dehydrogenates succinate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062184", "l": "testosterone 16-beta-hydroxylase activity", "d": ["Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}, {"i": "RHEA:46304", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77395", "l": "hydrogen cyanide + propanal = (2S)-2-hydroxybutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65385", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O => (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42004", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863012", "l": "Calpain cleaves p35 to p25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8979071", "l": "KDM6B binds iron (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62138", "l": "dGDP + GDP => dGMP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211191", "l": "Association of DFF with alpha:beta importin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.184", "l": "\"carbonyl reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61615", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 <=> 7-epi-cylindrospermopsin + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55330", "l": "9-cis-retinyl hexadecanoate + CoA => 9-cis-retinol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166387", "l": "The FA anion diffuses away laterally from UCP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58001", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose => (20S)-ginsenoside Rg3 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47239", "l": "eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030797", "l": "24-methylenesterol C-methyltransferase activity", "d": ["Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141437", "l": "Formation of the MCC complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297354", "l": "Acrosin Cleavage (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29713", "l": "cadaverine(out) + H(+)(out) => cadaverine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26518", "l": "3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392212", "l": "G alpha (i) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46670", "l": "5beta-dihydrodeoxycorticosterone + NADP(+) => 21-hydroxyprogesterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709454", "l": "EPOR binds EPOR agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13555", "l": "ADP + alpha-D-galactose 1-phosphate + H(+) => alpha-D-galactose + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730862", "l": "Autophosphorylation of LYN kinase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42519", "l": "H2O + L-gulono-1,4-lactone <=> H(+) + L-gulonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604722", "l": "Activation of proMMP9 by proteases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1008200", "l": "NFE2 binds the beta globin locus control region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033833", "l": "hydroxymethylfurfural reductase (NADH) activity", "d": ["Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54478", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+) => 1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0003880", "l": "protein C-terminal carboxyl O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55740", "l": "H2O + oleuropein = D-glucose + oleuropein aglycone", "d": [], "t": []}, {"i": "EC:3.2.1.206", "l": "\"oleuropein beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712085", "l": "ALK mutants phosphorylate STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211951", "l": "CYP1B1 4-hydroxylates EST17b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23466", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45928", "l": "15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106356", "l": "4-hydroxybenzoate 3-monooxygenase (NADPH) activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP+."], "t": []}, {"i": "RHEA:19477", "l": "4-hydroxybenzoate + H(+) + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52820", "l": "L-serine + succinyl-CoA = CoA + O-succinyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9710354", "l": "GSDME (1-270) binds cardiolipin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47813", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1011598", "l": "DOCKs bind to RhoGEFs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30043", "l": "fumarate + L-aspartate = iminosuccinate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32853", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004578", "l": "chitobiosyldiphosphodolichol beta-mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20349", "l": "H(+) + NADH + O2 + toluene = 2-hydroxytoluene + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52665", "l": "a short-chain (3S)-3-hydroxyacyl-CoA => a short-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21336", "l": "NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.107", "l": "\"pyridoxal 4-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791387", "l": "TP53 binds the ARID3A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55699", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O <=> an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22695", "l": "3-hydroxybenzoate + H(+) + NADH + O2 <=> 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047118", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity", "d": ["Catalysis of the reaction: 2,6-dioxo-6-phenylhexanoate + NADP+ = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205286", "l": "GRB2:SOS interacts with p-KIT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17182", "l": "a long-chain fatty aldehyde + FMNH2 + O2 => a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53924", "l": "a secondary amine + S-adenosyl-L-methionine = a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070748", "l": "interleukin-35 receptor binding", "d": ["Binding to an interleukin-35 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53769", "l": "allocholate + allodeoxycholoyl-CoA => allocholoyl-CoA + allodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835011", "l": "PINK1 phosphorylates PRKN at S65 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11112", "l": "H2O + isochorismate = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate", "d": [], "t": []}, {"i": "EC:3.3.2.1", "l": "\"isochorismatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019155", "l": "3-(imidazol-5-yl)lactate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191072", "l": "Synthesis of Cx43 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64301", "l": "3-phenylpropylamine + pyruvate => 3-phenylpropanal + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20180", "l": "pyridoxine + UDP-alpha-D-glucose <=> 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77389", "l": "an alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.244991688848543", "identifiers": [{"i": "GO:0016744", "l": "transketolase or transaldolase activity", "d": ["Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.2.1.-", "l": "\"Transketolases and transaldolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818574", "l": "TASP1 cleaves KMT2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64291", "l": "2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] <=> cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78633", "l": "(2E)-hexacosenoyl-CoA + H2O2 => hexacosanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37631", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31633", "l": "phosphate + pseudaminate => 2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66414", "l": "ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out) => ATP + glutathione(in) + H2O + taurochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0050997", "l": "quaternary ammonium group binding", "d": ["Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6802973", "l": "PLK3 phosphorylates CDC25C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013004", "l": "RHOA binds effectors at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33544", "l": "ergosteryl palmitate + H2O => ergosterol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0141107", "l": "methyltransferase regulator activity", "d": ["Binds to and modulates the activity of a methyltransferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47266", "l": "AMP + diphosphate + pristanoyl-CoA => 2,6,10,14-tetramethylpentadecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66484", "l": "16alpha-hydroxygypsogenate + UDP-alpha-D-glucose = 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29057", "l": "a ubiquinol + 2 H(+)(out) => a ubiquinone + 2 H(+)(in) + H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043864", "l": "indoleacetamide hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetamide + H2O = indole-3-acetate + NH3. Indole-3-acetamide is known as IAM and indole-3-acetate as IAA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022368", "l": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-42) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32098", "l": "acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose <=> CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374723", "l": "Nociceptin receptor binds to nociceptin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192912", "l": "NP binds vRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78223", "l": "D-allo-isoleucine + H2O + O2 = (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51560", "l": "(S)-bulbocapnine + S-adenosyl-L-methionine = (S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36793", "l": "hydroxyurea + L-ornithine => H2O + N(omega)-hydroxy-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55812", "l": "a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654569", "l": "Activated FGFR1 binds FRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2545196", "l": "FN1 dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12912", "l": "2 Fe(II)-[cytochrome] + 2 H(+) + nitrate <=> 2 Fe(III)-[cytochrome] + H2O + nitrite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.27", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44995", "l": "(R)-carnitine + 2-methylbutanoyl-CoA <=> CoA + O-2-methylbutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8980691", "l": "RHOA GEFs activate RHOA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.182", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21778", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate => (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018754", "l": "GDIs bind RHOH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62542", "l": "dihydroouabain + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36083", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43637", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) => 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66198", "l": "CoA + H(+) + N-acetyltryptamine => acetyl-CoA + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683113", "l": "Defective ABCC8 does not form functional KATP channels, causing hyperinsulinemic hypoglycemia (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34196", "l": "2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 => 2 aureusidin 6-O-beta-glucoside + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76126", "l": "a dicarboxylate(in) + prostaglandin E2(out) <=> a dicarboxylate(out) + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75151", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = diphosphate + neoverrucosan-5beta-ol", "d": [], "t": []}, {"i": "EC:4.2.3.207", "l": "\"neoverrucosan-5beta-ol synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018666", "l": "2,4-dichlorophenol 6-monooxygenase activity", "d": ["Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32251", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+) = (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75993", "l": "a dicarboxylate(out) + N-benzoylglycine(in) => a dicarboxylate(in) + N-benzoylglycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77788", "l": "an N-(1-deoxy-beta-D-fructopyranos-1-yl)amine + H2O + O2 => 2-dehydro-D-glucose + an aliphatic amine + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018766", "l": "dihydrophloroglucinol hydrolase activity", "d": ["Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78932", "l": "a long-chain (3R)-hydroxyacyl-CoA => a long-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21234", "l": "NH4(+) + trans-urocanate => L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40185", "l": "(2E)-tetradecenoyl-CoA + H2O2 => O2 + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362427", "l": "Hh-Np binds GPC5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16269", "l": "aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) = 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH", "d": [], "t": []}, {"i": "EC:1.7.1.6", "l": "\"azobenzene reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40881", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26453", "l": "CoA + NADP(+) + succinate semialdehyde <=> H(+) + NADPH + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13081", "l": "biotin amide + H2O = biotin + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32397", "l": "(1S,4S)-dihydrocarvone + H(+) + NADH => (1S,2S,4S)-dihydrocarveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833674", "l": "CDH11 forms homotypic trans dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39744", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50929", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18355", "l": "ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate => ATP + H2O + K(+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757454", "l": "ST translocates from cytosol to mitochondrial matrix of hepatocytes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210805", "l": "Removal of miRNA passenger strand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76272", "l": "N,N-dimethylglycine(in) => N,N-dimethylglycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55552", "l": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60885", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O => (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481010", "l": "Surface deployment of platelet dense granule membrane components (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25852", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.5", "l": "\"acyl-CoA 11-(Z)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15585", "l": "15-cis-phytoene + 4 A = 4 AH2 + all-trans-lycopene", "d": [], "t": []}, {"i": "EC:1.3.99.31", "l": "\"phytoene desaturase (lycopene-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46389", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27705", "l": "aldehydo-D-galacturonate <=> keto-D-tagaturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167056", "l": "SHC binds to the activated TrkA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70975", "l": "CS acetylates OA to citrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65461", "l": "acetyl-CoA + hexan-1-ol => CoA + hexyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.6", "l": "\"nucleoside diphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080066", "l": "3-methylthiopropyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 3-methylthiopropyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 3-methylthiopropyl-glucosinolate + adenosine 3',5'-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39804", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) => (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64994", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine => acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78970", "l": "a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O <=> a 1,2-diacyl-sn-glycerol + glycerol 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374662", "l": "Translocation of Ezrin to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15723", "l": "glyoxylate + H(+) + NADH + NH4(+) => glycine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649108", "l": "HTR3A pentamer binds 5HT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62917", "l": "an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine => an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35597", "l": "2 H(+) + maleylacetate => benzene-1,2,4-triol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334794", "l": "FABPs bind LCFAs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39553", "l": "(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+) => (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73718", "l": "UBF-1 Binds rDNA Promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9824995", "l": "GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022359", "l": "MECP2:SIN3A complex binds GRIA2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77983", "l": "9-hydroxy-octadecanoate + a triacylglycerol = 9-(acyloxy)-octadecanoate + a 2,3-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351948", "l": "Mitochondrial recruitment of Drp1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38878", "l": "uridine(2604) in 23S rRNA <=> pseudouridine(2604) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70153", "l": "6alpha-hydroxy-28-norcastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53153", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.000320632972077", "identifiers": [{"i": "GO:0015295", "l": "solute:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56904", "l": "an acyl-AMP + CoA = AMP + an acyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65688", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950716", "l": "IL27RA binds JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37533", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45349", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75138", "l": "NADP(+) + neopine <=> H(+) + NADPH + neopinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.222", "l": "\"aurachin C monooxygenase/isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804188", "l": "PRDM1 represses TP53 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218847", "l": "PAK2 binds NCK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26224", "l": "abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21092", "l": "12-hydroxydihydrochelirubine + S-adenosyl-L-methionine = dihydromacarpine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.120", "l": "\"12-hydroxydihydrochelirubine 12-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63269", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72940", "l": "2 Na(+)(out) + propanoate(out) => 2 Na(+)(in) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39113", "l": "4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH => 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0061605", "l": "molybdopterin-synthase adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75951", "l": "2-oxoglutarate + O2 + oripavine = CO2 + formaldehyde + neomorphinone + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36138", "l": "(2E)-hexadecenal + H2O + NAD(+) <=> (E)-hexadec-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70415", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + H2O = (3,5-dihydroxyphenyl)acetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390835", "l": "DRD1,5 bind DA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047574", "l": "4-acetamidobutyryl-CoA deacetylase activity", "d": ["Catalysis of the reaction: 4-acetamidobutanoyl-CoA + H2O = 4-aminobutanoyl-CoA + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36643", "l": "emodin + S-adenosyl-L-methionine = H(+) + questin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.283", "l": "\"emodin O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691421", "l": "BTK binds BTK inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205321", "l": "Interaction of KIT and sSCF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50610", "l": "12-oxo-leukotriene B4 + H(+) + NADPH => leukotriene B4 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.2.-", "l": "\"Hydroxymethyl-, formyl- and related transferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21491", "l": "dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O <=> beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047349", "l": "D-ribitol-5-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24454", "l": "[protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine => L-glutamyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852362", "l": "GTSE1 binds CDKN1A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71063", "l": "L-arginine(in) + L-histidine(out) = L-arginine(out) + L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48056", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = beta-D-glucosylceramide + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8862771", "l": "PLA2G2A binds bacterial phospholipids (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848316", "l": "IL36 binds IL1RL2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61761", "l": "rebaudioside B + UDP-alpha-D-glucose => rebaudioside A + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016034", "l": "maleylacetoacetate isomerase activity", "d": ["Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18096", "l": "5,6-dihydrouracil + NADP(+) <=> H(+) + NADPH + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74170", "l": "H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin] <=> formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9648268", "l": "HTR1A binds HTR1A antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044730", "l": "bone sialoprotein binding", "d": ["Binding to a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1671687", "l": "PRLR activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55532", "l": "H(+) + H2O + L-phenylalanine + O2 = 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:4.1.1.109", "l": "\"phenylacetaldehyde synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371353", "l": "Soluble TNF-α binds TNFR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10106", "l": "CO2 + gibberellin A1 + succinate => 2-oxoglutarate + gibberellin A20 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16980", "l": "acetoacetate + coenzyme M + NADP(+) <=> 2-oxopropyl-coenzyme M + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709396", "l": "CO translocates from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44114", "l": "CoA + nonyl hexadecanoate => hexadecanoyl-CoA + nonan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10511", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate <=> aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169394", "l": "ISGylation of IRF3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67312", "l": "(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = myceliothermophin E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43681", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.72", "l": "\"glycerol dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72026", "l": "nicotinate(in) + urate(out) <=> nicotinate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79157", "l": "(4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside(out) + ADP + H(+) + phosphate => (4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17184", "l": "a long-chain fatty aldehyde + FMNH2 + O2 <=> a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11481", "l": "3-hydroxybenzoate + H(+) + NADPH + O2 => 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52986", "l": "6-carboxyhexanoyl-[ACP] + reduced [flavodoxin] => 7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662597", "l": "MT1H binds cadmium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72370", "l": "estrone 3-sulfate(out) + succinate(in) <=> estrone 3-sulfate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35996", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046810", "l": "host cell extracellular matrix binding", "d": ["Binding to the extracellular matrix of a host cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785607", "l": "FANCM binds FAAP24 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43722", "l": "juvenile hormone III + S-adenosyl-L-homocysteine => juvenile hormone III carboxylate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665406", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693783", "l": "NAALADases hydrolyse NAAG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66003", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5138459", "l": "WNT5A:FZD4 is endocytosed (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018781", "l": "S-triazine hydrolase activity", "d": ["Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine = 1-hydroxy-S-triazine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865482", "l": "KMT2A (MLL) binds RUNX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42860", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40743", "l": "(20S)-ginsenoside Rd + 2 H2O = (20S)-ginsenoside C-K + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57349", "l": "3-hydroxy-4-methyl-L-kynurenine + H2O => 3-hydroxy-4-methylanthranilate + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30823", "l": "UDP-N-acetyl-alpha-D-glucosamine = H2O + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}, {"i": "EC:4.2.1.135", "l": "\"UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805470", "l": "AMPK phosphorylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8979071", "l": "KDM6B binds iron (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909732", "l": "Phosphorylation of STAT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77746", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64187", "l": "H2O + N-(9Z-octadecenoyl)-L-tyrosine <=> (9Z)-octadecenoate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449958", "l": "IL7:IL7R:JAK1 binds IL2RG:JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047791", "l": "cucurbitacin delta23-reductase activity", "d": ["Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24203", "l": "4-aminobenzoate + H(+) <=> aniline + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70967", "l": "IDH3 complex decarboxylates isocitrate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990050", "l": "phosphatidic acid transfer activity", "d": ["Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74965", "l": "L-leucine(in) + L-ornithine(out) + Na(+)(in) => L-leucine(out) + L-ornithine(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41990", "l": "5alpha-pregnane-3,20-dione + H(+) + NADH => 3beta-hydroxy-5alpha-pregnane-20-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683622", "l": "mRNA5 is translated to protein M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37438", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate <=> a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869694", "l": "oxPL binds CD14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40108", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72180", "l": "Cleavage of mRNA at the 3'-end (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53395", "l": "2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] <=> (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2203516", "l": "Alpha-1-Microglobulin is cleaved (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60419", "l": "diglucosyl-enterobactin + H2O <=> H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2512800", "l": "SCARB1:ligand is endocytosed (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48436", "l": "H2O + pentanoate ester = an aliphatic alcohol + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700171", "l": "Active ALK phosphorylates PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047039", "l": "tetrahydroxynaphthalene reductase activity", "d": ["Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034800", "l": "trinitrophenol dihydride denitratase activity", "d": ["Catalysis of the reaction: trinitrophenol dihydride Meisenheimer complex (aci form) = 2,4-dinitrophenol hydride Meisenheimer complex + NO2. Trinitrophenol is also known as TNP and dinitrophenol is also known as DNP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10072", "l": "N,N-dimethylglycine + S-adenosyl-L-methionine = glycine betaine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.161", "l": "\"dimethylglycine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16887", "l": "(4Z,15Z)-bilirubin IXalpha + bilirubin IXalpha bis-beta-D-glucuronoside => 2 (4E,15E)-bilirubin IXalpha C8-beta-D-glucuronoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64504", "l": "AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine = 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050060", "l": "long-chain-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797554", "l": "ABP1 binds SHANK proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167429", "l": "The receptor:G-protein complex  binds GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47276", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653745", "l": "Translation of ATF5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78069", "l": "a 1,3-diacylglycerol + an all-trans-retinyl ester => a triacylglycerol + all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202692", "l": "PIP3 binds to RhoA and activates it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26466", "l": "a 2-demethylmenaquinone + S-adenosyl-L-methionine = a menaquinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32697", "l": "(-)-car-3-ene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49315", "l": "2-trans,4-trans-xanthoxin + NAD(+) <=> 2-trans-(+)-abscisic aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730902", "l": "Oligomerization of p-CARMA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22662", "l": "a fatty acyl-[ACP] + AMP + diphosphate => a fatty acid + ATP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52949", "l": "deoxycholate + UDP-alpha-D-glucuronate => deoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917700", "l": "MVB Vesicle Formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27289", "l": "(S)-acetoin + NAD(+) <=> diacetyl + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13888", "l": "H2O + stipitatonate <=> CO2 + stipitatate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726949", "l": "PTGIR binds PTGIR agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37290", "l": "ATP + H2O + L-alanyl-L-leucine(out) <=> ADP + H(+) + L-alanyl-L-leucine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28785", "l": "glycine + L-cysteine => H2O + L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047277", "l": "globoside alpha-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46872", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA = a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12889", "l": "L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.45", "l": "\"L-gulonate 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043783", "l": "oxidoreductase activity, acting on metal ions, flavin as acceptor", "d": ["Catalysis of an oxidation-reduction in which the metal ion is reduced and flavin acts as an electron acceptor."], "t": []}, {"i": "EC:1.16.8.-", "l": "\"With a flavin as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0034318", "l": "alcohol O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77985", "l": "9-(acyloxy)-octadecanoate + a 2,3-diacyl-sn-glycerol => 9-hydroxy-octadecanoate + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16969", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose", "d": [], "t": []}, {"i": "EC:5.1.3.13", "l": "\"dTDP-4-dehydrorhamnose 3,5-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55190", "l": "5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate => 5-methyluridine(54) in tRNA + ATP + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1237129", "l": "Acireductone is created (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59081", "l": "bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose => 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53284", "l": "NAD(+) + scyllo-inosose = 3-dehydro-scyllo-inosose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43905", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol => 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36813", "l": "CoA + GDP-N-acetyl-alpha-D-perosamine + H(+) => acetyl-CoA + GDP-alpha-D-perosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66236", "l": "IC-asc-C9-CoA + O2 = H2O2 + IC-asc-DeltaC9-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41591", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938108", "l": "SERPINB13 binds cathepsin L (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.109", "l": "\"iron(III) salmochelin esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51608", "l": "(R)-2-hydroxyglutarate + pyruvate = (R)-lactate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41423", "l": "2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 <=> CO2 + grixazone B + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928627", "l": "EPHB phosphorylates TIAM1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.17", "l": "\"4-hydroxy-4-methyl-2-oxoglutarate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032500", "l": "muramyl dipeptide binding", "d": ["Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047895", "l": "formaldehyde dismutase activity", "d": ["Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66031", "l": "AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine <=> (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77602", "l": "2 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) <=> 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55407", "l": "[phosphate](n) + UTP <=> [phosphate](n+1) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64170", "l": "(2S)-2-aminobutanoate + formaldehyde => 2-ethyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19587", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH => lithocholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.38", "l": "\"plasmepsin I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71824", "l": "3,3'-diiodo-L-thyronine(out) => 3,3'-diiodo-L-thyronine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65445", "l": "butanoyl-CoA + hexan-1-ol => CoA + hexyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54142", "l": "5-methylcytidine(49) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA precursor + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102426", "l": "myricetin-3-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: myricetin 3-O-beta-D-glucopyranoside + UDP-alpha-D-glucose = myricetin 3-O-gentiobioside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10167", "l": "(2R)-2-phosphoglycerate <=> H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696960", "l": "USP49 deubiquitinates H2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11503", "l": "3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O <=> 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110212", "l": "NTHL1 glycosylase mediated recognition and binding of dihydrouracil (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44588", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63946", "l": "an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+) => a fatty acyl-CoA + sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389762", "l": "Phosphorylation of PD-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0017150", "l": "tRNA dihydrouridine synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419334", "l": "Melatonin receptors can bind melatonin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60003", "l": "hydroxymethylphosphonate + O2 <=> formate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198458", "l": "Efflux of Glc from the endoplasmic reticulum (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72234", "l": "chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out) <=> chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71617", "l": "(S)-malate(out) + sulfate(in) => (S)-malate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14564", "l": "(E,E)-piperoyl-CoA + piperidine <=> CoA + H(+) + piperine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75564", "l": "cyathadiol + O2 + reduced [NADPH--hemoprotein reductase] => cyathatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28293", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (5S,9S,10S)-drim-7-en-11-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696358", "l": "TREM,CD300 binds lipids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56955", "l": "CTP + pyruvate <=> CDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9627104", "l": "XIAP binds CASP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28478", "l": "galactarate(in) + H(+)(in) = galactarate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794830", "l": "SLC22A8 transports Cipro into renal cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45852", "l": "Co(II)-factor III + H(+) + S-adenosyl-L-methionine = Co(II)-factor IV + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229283", "l": "LCNs bind lipids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35136", "l": "L-alanyl-L-glutamate(out) => L-alanyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47850", "l": "CO2 + diphosphate + thiamine phosphate => 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18408", "l": "H2O + L-alanine + NAD(+) <=> H(+) + NADH + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50354", "l": "3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase] => 3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158357", "l": "factor XIIa binds SERPING1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850945", "l": "Casein kinase II phosphorylates PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001962", "l": "alpha-1,3-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130706", "l": "MHC class II antigen processing (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376122", "l": "DSCAM/DSCAML1 homodimerization (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24772", "l": "7(1)-hydroxychlorophyllide a + NADP(+) = chlorophyllide b + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16312", "l": "H2O + taurochenodeoxycholate <=> chenodeoxycholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43977", "l": "H(+) + hexadecanoate + NADPH + O2 => 14-hydroxyhexadecanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36794", "l": "H2O + N(omega)-hydroxy-L-arginine <=> hydroxyurea + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647632", "l": "CASP3 cleaves GSDME (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322971", "l": "Defective MUT does not isomerise L-MM-CoA to SUCC-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209102", "l": "SLMB binds to phosphorylated ARM to form the 'destruction complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9861734", "l": "PDH E1 decarboxylates PYR, transferring acetyl to DLAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55076", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) = 3-methylsulfanylpropanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76052", "l": "Binding of TFIIIA To type 1 Promoter (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.21", "l": "\"chondroitin-sulfate-ABC exolyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77268", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycerol => 1,3-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322422", "l": "Beta-catenin recruits SMARCA4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-481007", "l": "Exocytosis of platelet alpha granule contents (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38957", "l": "an N-acylsphing-4-enine 1-phosphate(out) => an N-acylsphing-4-enine 1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798748", "l": "Exocytosis of secretory granule lumen proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0015651", "l": "quaternary ammonium group transmembrane transporter activity", "d": ["Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18788", "l": "A + gibberellin A12 aldehyde + H2O <=> AH2 + gibberellin A12 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9825772", "l": "SIRT1 deacetylates HINT1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65388", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37935", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662851", "l": "Defective DCXR does not reduce L-xylulose to xylitol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40275", "l": "hexadecanedioyl-CoA + O2 = (2E)-hexadecenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165043", "l": "Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35252", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O => ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13509", "l": "H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}, {"i": "EC:2.7.7.23", "l": "\"UDP-N-acetylglucosamine diphosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70146", "l": "6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12573", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP => adenosylcob(III)inamide + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32271", "l": "(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.85", "l": "\"3-isopropylmalate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36845", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA => (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050809", "l": "diazepam binding", "d": ["Binding to diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60033", "l": "8-oxo-GTP + H2O => 8-oxo-GDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63769", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23456", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = A + crepenynate + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632412", "l": "PTK2 is recruited to methylated ESR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38910", "l": "(R)-reticuline + S-adenosyl-L-methionine <=> (R)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43668", "l": "ATP + hexacosanoyl-CoA + hydrogencarbonate = 2-carboxyhexacosanoyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31981", "l": "H2O + NADP(+) + trimethylamine N-oxide => NADPH + O2 + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69263", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate <=> (3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35519", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74905", "l": "(2E)-but-2-enoyl-AMP + diphosphate => (2E)-2-butenoate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44791", "l": "2-demethylmenaquinol-11 + S-adenosyl-L-methionine <=> H(+) + menaquinol-11 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51388", "l": "acetyl-CoA + dopamine = CoA + H(+) + N-acetyl-dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33657", "l": "(9Z)-octadecenoate(in) => (9Z)-octadecenoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78408", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + sesterfisherol => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + sesterfisherate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45743", "l": "2-oxoglutarate + L-ectoine + O2 <=> 5-hydroxyectoine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59239", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + isoelisabethatriene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69152", "l": "Removal of remaining Flap (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071558", "l": "histone H3K27me2/H3K27me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49041", "l": "(-)-5'-demethylyatein + S-adenosyl-L-methionine => (-)-yatein + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034911", "l": "phthalate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41670", "l": "chelirubine + NADPH => dihydrochelirubine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13775", "l": "(S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56951", "l": "pyruvate + UTP <=> H(+) + phosphoenolpyruvate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48270", "l": "canthaxanthin + H2O => 4',4'-dihydroxyechinenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55344", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140761", "l": "sequestered tissue factor -> tissue factor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797553", "l": "Protein 4.1 binds CASK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176517", "l": "SULTs transfer (SO4)2- group to PREG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70657", "l": "H(+)(out) + sarcosine(out) => H(+)(in) + sarcosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58806", "l": "5'-ApG-3' + phosphate => 5'-pApG-3' + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031728", "l": "CCR3 chemokine receptor binding", "d": ["Binding to a CCR3 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20583", "l": "2 H(+) + hydroxylamine + NADH => H2O + NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2467775", "l": "Autocleavage of ESPL1 (Separase) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010292", "l": "GTP:GDP antiporter activity", "d": ["Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197690", "l": "Detachment of WASP/WAVE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429683", "l": "CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164521", "l": "Insertion of gp41 fusion peptide into the target membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39115", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.2.2", "l": "\"nebramycin 5' synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38705", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16648", "l": "H2O + hexadecanoyl-CoA <=> CoA + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52337", "l": "a long-chain fatty acid + ATP + H(+) => a long-chain fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28740", "l": "Cd(2+)(in) + H(+)(out) => Cd(2+)(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27489", "l": "2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.28", "l": "\"D-sedoheptulose-7-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37189", "l": "1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25426", "l": "5-phospho-alpha-D-ribose 1-diphosphate + guanine => diphosphate + GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17288", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16125", "l": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16476", "l": "cyclohexane-1,3-dione + H2O <=> 5-oxohexanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004636", "l": "phosphoribosyl-ATP diphosphatase activity", "d": ["Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H2O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37226", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36269", "l": "formaldehyde + H2O + NAD(+) + theobromine => caffeine + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44841", "l": "(R)-carnitine + octadecanoyl-CoA => CoA + O-octadecanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162192", "l": "COQ2 ligates all-E-10PrP2 to PHB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.145607380047934", "identifiers": [{"i": "GO:0043891", "l": "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59415", "l": "2-oxosuccinamate + H2O <=> NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20936", "l": "2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19373", "l": "H2O + L-saccharopine + NADP(+) = 2-oxoglutarate + H(+) + L-lysine + NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.8", "l": "\"saccharopine dehydrogenase (NADP(+), L-lysine-forming)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40252", "l": "4-O-methylrhodomycin D + H2O => 10-carboxy-13-deoxydaunorubicin + H(+) + methanol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64283", "l": "(S)-1-phenylethylamine + pyruvate <=> acetophenone + L-alanine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46927", "l": "(R)-2-hydroxy-4-methylpentanoyl-CoA <=> 4-methylpent-2-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33142", "l": "L-alanine(out) + L-aspartate(in) <=> L-alanine(in) + L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858475", "l": "TNFSF9 binds TNFRSF9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46227", "l": "(E)-feruloyl-CoA + H2O <=> (E)-ferulate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29749", "l": "3-phenylpropanoate(out) => 3-phenylpropanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22094", "l": "15,16-dihydrobiliverdin + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => (3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65780", "l": "2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53324", "l": "2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48075", "l": "a ganglioside GM1 (d18:1(4E)) + H2O <=> a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694428", "l": "LMAN family proteins bind glycosylated cargo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31115", "l": "ATP + biotin + H(+) = biotinyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632667", "l": "SMO dimer binds ARRB and KIF3A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25897", "l": "H(+) + malonate => acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45270", "l": "4',4'-dihydroxyechinenone + A + H2O => 4'-hydroxyechinenone + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42000", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = an isogloboside iGb3Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9010872", "l": "SLIT2 binds Dystroglycan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48915", "l": "a ganglioside GD1a + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GT1a + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70697", "l": "chloride(in) + glycine(in) + 3 Na(+)(in) => chloride(out) + glycine(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.65", "l": "\"levanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1467269", "l": "Beta-defensins bind microbial membranes causing disruption (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000327", "l": "PLK1 phosphorylates BORA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78466", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose <=> an isogloboside iGb3Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41217", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28480", "l": "galactarate(out) + H(+)(out) => galactarate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986446", "l": "IL26 binds IL20RA:JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014433", "l": "RHOG GEFs activate RHOG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25359", "l": "(3Z)-phycoerythrobilin + 2 oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + 4 H(+) + 2 reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.6", "l": "\"phycoerythrobilin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75802", "l": "Na(+)(out) + pyruvate(out) <=> Na(+)(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449829", "l": "IL11 binds IL11RA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62632", "l": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O", "d": [], "t": []}, {"i": "EC:1.11.1.27", "l": "\"glutathione-dependent peroxiredoxin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043993", "l": "histone H3K18 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937613", "l": "CRHBP binds CRH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014456", "l": "GDIs block activation of RHOG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418858", "l": "RhoGTPase GEF's recruited to DCC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59181", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O => 2 AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45480", "l": "gamma-hexachlorocyclohexane = (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264615", "l": "Loading of acetylcholine in synaptic vesicles (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36771", "l": "beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-beta-L-fucose = alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.308", "l": "\"GDP-Fuc:beta-D-Gal-1,3-alpha-D-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,2-fucosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173705", "l": "C5b binds C6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700168", "l": "Active ALK phosphorylates IRS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67618", "l": "8-oxo-GMP + diphosphate + H(+) => 8-oxo-GTP + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102392", "l": "decanoate-[HmqF protein] ligase activity", "d": ["Catalysis of the reaction: decanoate + ATP(4-) + an HmqF protein = AMP(2-) + diphosphoric acid + a decanoyl-HmqF protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27756", "l": "(R)-lactate + H(+) => H2O + methylglyoxal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43361", "l": "an N-acylsphinganine + UDP-alpha-D-glucose => an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109813", "l": "GRB2-1 binds SOS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41221", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58202", "l": "6-oxohexanoate + L-glutamate => 2-oxoglutarate + 6-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45224", "l": "(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA = (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18107", "l": "ADP + Ca(2+)(out) + H(+) + phosphate => ATP + Ca(2+)(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44096", "l": "decan-1-ol + hexadecanoyl-CoA = CoA + decanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10040", "l": "adenosine 3',5'-bisphosphate + H2O = AMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32890", "l": "all-trans-beta-carotene + O2 <=> 2 all-trans-retinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657617", "l": "ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62754", "l": "(S)-2-methylbutanoate + H(+) + pravastatin diol lactone => H2O + pravastatin lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33908", "l": "4-(methylamino)butanoate + H2O + O2 => 4-aminobutanoate + formaldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34215", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) = 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.83", "l": "\"3-succinoylsemialdehyde-pyridine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50537", "l": "prostaglandin E2 => H2O + prostaglandin A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43406", "l": "H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP => N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5591086", "l": "SERPINA5 binds activated protein C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18210", "l": "(2E)-geranyl diphosphate => (2S,4R)-bornyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52674", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate => 2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52020", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 = A + H2O + resolvin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75960", "l": "(S)-scoulerine + 2-oxoglutarate + O2 => (S)-3-O-demethylscoulerine + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22512", "l": "3 H(+) + precorrin-8X = hydrogenobyrinate", "d": [], "t": []}, {"i": "EC:5.4.99.61", "l": "\"precorrin-8X methylmutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72663", "l": "De novo formation of eIF2:GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162195", "l": "COQ4 decarboxylates MHDB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53665", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) => H(+) + 2 H2O + pyridinestrone carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825840", "l": "MITF-M-dependent TBX2 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19355", "l": "cholate + glycine => glycocholate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12364", "l": "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside", "d": [], "t": []}, {"i": "EC:1.10.5.1", "l": "\"ribosyldihydronicotinamide dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15744", "l": "2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) <=> 2,5-dichlorohydroquinone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42952", "l": "cytidine(49) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5252133", "l": "ATP6AP1 binds V-ATPase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44613", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69807", "l": "benzoyl-AMP + CoA = AMP + benzoyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30187", "l": "(S)-dihydroorotate + a quinone = a quinol + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56378", "l": "3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+) => 3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58392", "l": "4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428123", "l": "KDSR reduces 3-ketosphingoid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018421", "l": "UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity", "d": ["Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398185", "l": "LARG binds plexin B1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29421", "l": "H(+)(in) + Na(+)(out) => H(+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684169", "l": "G6B binds PTPN6,PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37971", "l": "H(+) + NADPH + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.19.n4", "l": "\"stearoyl-CoA 9-desaturase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5651828", "l": "PARG dePARylates PARP1,PARP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42799", "l": "(9Z,12Z)-octadecadienoyl-CoA + cholesterol <=> cholesteryl (9Z,12Z)-octadecadienoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018136", "l": "peptidyl-thiazoline dehydrogenase activity", "d": ["Catalysis of the reduction of a peptide-linked thiazoline to thiazole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58448", "l": "N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32439", "l": "(+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.39", "l": "\"epi-isozizaene 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23473", "l": "2 alpha,alpha'-trehalose 6-mycolate => alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120021", "l": "oxysterol transfer activity", "d": ["Removes oxysterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66953", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose => alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11696", "l": "3'-demethylstaurosporine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + staurosporine", "d": [], "t": []}, {"i": "EC:2.1.1.139", "l": "\"3'-demethylstaurosporine O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654159", "l": "Activated FGFR2 binds PLCG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69557", "l": "D-glucose(out) + H(+)(out) => D-glucose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170022", "l": "ionotropic bitter taste receptor activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific bitter compound has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47655", "l": "D-ribitol 1-phosphate + H2O <=> phosphate + ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9837337", "l": "DCAKD phosphorylates DP-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954056", "l": "E2F6 binds TFDP2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65352", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48245", "l": "a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate => a ganglioside GM1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140473", "l": "telomere-nuclear envelope anchor activity", "d": ["The binding activity of a molecule that brings together the telomeric region of a chromosome and the inner nuclear membrane by interacting with both the telomere and the nuclear membrane, in order to establish and maintain the telomeric location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65169", "l": "AH2 + O2 + preaustinoid A => A + H2O + preaustinoid A1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50896", "l": "8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O = (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56317", "l": "3-amino-4-hydroxybenzoate + acetyl-CoA => 3-acetylamino-4-hydroxybenzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34710", "l": "AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65280", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate = 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163666", "l": "Formation of ChREBP:MLX heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430311", "l": "Rsu-1 interacts with Pinch1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627107", "l": "XIAP binds CASP7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932184", "l": "Expression of HIGD1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72663", "l": "De novo formation of eIF2:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023840", "l": "HATs and coactivators are recruited to the CTSD gene (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50374", "l": "an N-acylsphingoid base 1-phosphate(out) => an N-acylsphingoid base 1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23965", "l": "(E)-coniferaldehyde + H2O + NADP(+) => (E)-ferulate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68920", "l": "ATP + H(+) + NADPH + pentanoate = AMP + diphosphate + NADP(+) + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983138", "l": "Transport of MHC heterotrimer to ER exit site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038048", "l": "dynorphin receptor activity", "d": ["Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40793", "l": "CoA + H(+) + hexacosanoate => H2O + hexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17746", "l": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose => beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784959", "l": "BPHL hydrolyses VACV to ACV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21450", "l": "16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate => 16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3785768", "l": "MRN complex binds DNA double strand breaks (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990714", "l": "hydroxyproline O-galactosyltransferase activity", "d": ["Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218824", "l": "p-6Y-VEGFR2 binds FYN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74295", "l": "n H(+)(out) + serotonin(in) = n H(+)(in) + serotonin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48194", "l": "(2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63319", "l": "(9Z,12Z)-octadecadienoate + O2 <=> 9-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69884", "l": "L-ascorbate(out) + 2 Na(+)(out) => L-ascorbate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707051", "l": "UBXN1 binds BRCA1:BARD1 heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619542", "l": "AMPK negatively regulates binding of MAPT to microtubules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202709", "l": "JAM2 dimerises (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74395", "l": "2 (S)-lactate(in) + prostaglandin E1(out) = 2 (S)-lactate(out) + prostaglandin E1(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28937", "l": "oxaloacetate + pyruvate => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.136185332556494", "identifiers": [{"i": "GO:0016782", "l": "transferase activity, transferring sulphur-containing groups", "d": ["Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.8.-.-", "l": "\"Transferring sulfur-containing groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804741", "l": "MDM2 forms homo- or heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10004", "l": "benzyl isothiocyanate = benzyl thiocyanate", "d": [], "t": []}, {"i": "EC:5.99.1.1", "l": "\"thiocyanate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37418", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48878", "l": "L-seryl-[protein] + N-acetyl-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696358", "l": "TREM,CD300 binds lipids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11418", "l": "1,6-bis-O-galloyl-beta-D-glucose + D-glucose => 2 1-O-galloyl-beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36585", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH => dTDP-alpha-D-fucose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390425", "l": "FAR1 reduces PalmCoA to HXOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36370", "l": "(S)-alpha-hydroxyglutarate-gamma-lactone + H2O <=> 2-hydroxyglutarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9861642", "l": "NEK1 phosphorylates ME1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928627", "l": "EPHB phosphorylates TIAM1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432381", "l": "PDP1 replaces VRI as binder to Clk and cry genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57083", "l": "glutathione + S-methyl-1-thio-D-xylulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72329", "l": "3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34930", "l": "H(+) + NADPH + selenodiglutathione <=> glutathione + glutathioselenol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0033857", "l": "diphosphoinositol-pentakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75044", "l": "L-cystine(out) + L-leucine(in) => L-cystine(in) + L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16773", "l": "a ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GM1 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.62", "l": "\"ganglioside galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77504", "l": "3-phenylpropanal + hydrogen cyanide => (2S)-2-hydroxy-4-phenylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53341", "l": "5,6-dihydrouridine(20) in tRNA + NAD(+) => H(+) + NADH + uridine(20) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71202", "l": "L-ornithine(in) <=> L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28454", "l": "N(6)-(D-fructosyl)-L-lysine(in) = N(6)-(D-fructosyl)-L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61753", "l": "steviolbioside + UDP-alpha-D-glucose => H(+) + rebaudioside B + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004100", "l": "chitin synthase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25020", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986480", "l": "IL26:IL20RA:JAK1 binds IL10RB:TYK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68239", "l": "L-glutamine(in) + Na(+)(in) <=> L-glutamine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31116", "l": "ATP + biotin + H(+) => biotinyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33343", "l": "glycine + O2 = 2-iminoacetate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54510", "l": "beta-heptaprene + diphosphate => all-trans-heptaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43699", "l": "H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate <=> diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052839", "l": "inositol diphosphate tetrakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.5", "l": "\"cytidine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22861", "l": "ATP + H(+) + nicotinate beta-D-ribonucleotide => deamido-NAD(+) + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450550", "l": "PKCalpha phosphorylates HuR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008794", "l": "arsenate reductase (glutaredoxin) activity", "d": ["Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10282", "l": "caffeine + H(+) + S-adenosyl-L-homocysteine => 1,7-dimethylxanthine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051959", "l": "dynein light intermediate chain binding", "d": ["Binding to a light intermediate chain of the dynein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72511", "l": "(R)-carnitine(out) + 2-oxoglutarate(in) = (R)-carnitine(in) + 2-oxoglutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11229", "l": "(2S)-flavan-4-ol + NADP(+) => (2S)-flavanone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73238", "l": "2,6-dichlorobenzoquinone + H2O <=> 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19057", "l": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O", "d": [], "t": []}, {"i": "EC:1.11.1.12", "l": "\"phospholipid-hydroperoxide glutathione peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983285", "l": "RAD51B binds RAD51C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60368", "l": "urate(out) = urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698928", "l": "Late (L) Gene Expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.418", "l": "\"plant 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19497", "l": "H(+) + L-aspartate = beta-alanine + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.11", "l": "\"aspartate 1-decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29412", "l": "glycolate(in) + H(+)(in) => glycolate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0050545", "l": "sulfopyruvate decarboxylase activity", "d": ["Catalysis of the reaction: 3-sulfopyruvate + H+ = CO2 + sulfoacetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79077", "l": "(4Z,15Z)-bilirubin IXalpha C8,C12-beta-D-bisglucuronoside + UDP => (4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57620", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38906", "l": "a sphingomyelin(in) + ATP + H2O <=> a sphingomyelin(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9855908", "l": "p-T153 USF1 dimer binds the TYR promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21411", "l": "H2O + L-phenylalanine + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31763", "l": "a 2-oxocarboxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid", "d": [], "t": []}, {"i": "EC:2.6.1.88", "l": "\"methionine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74631", "l": "3-methyl-2-oxobutanoate + O-acetyl-L-homoserine = (6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49876", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69537", "l": "alpha-D-tagatopyranose 1-phosphate + ATP => ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351849", "l": "Caspase-mediated cleavage of Etk (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0008240", "l": "tripeptidyl-peptidase activity", "d": ["Catalysis of the release of an N-terminal tripeptide from a polypeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169398", "l": "ISGylation of host protein filamin B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16810", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate => pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002401", "l": "Association of procollagen type XVIII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70278", "l": "H2O + raffinose <=> D-galactose + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45791", "l": "(9Z)-hexadecenoyl-CoA + 1,2-dihexadecanoyl-sn-glycerol <=> 1,2-dihexadecanoyl-3-(9Z-hexadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49225", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29093", "l": "a ubiquinol + 4 H(+)(out) + NAD(+) => a ubiquinone + 5 H(+)(in) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.58", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64260", "l": "(9Z,12Z)-octadecadienoyl-CoA + glycine = CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9611721", "l": "β1-agonists bind ADRB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42787", "l": "adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33825", "l": "NAD(+) + tetrahydro-4-hydroxyphenylpyruvate => 3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21895", "l": "D-arabinose + NADP(+) <=> D-arabinono-1,4-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689085", "l": "ATXN3 binds polyUb-PARK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43628", "l": "L-serine + NAD(+) = aminoacetaldehyde + CO2 + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.387", "l": "\"L-serine 3-dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53240", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203613", "l": "depalmitoylation of eNOS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39522", "l": "3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67111", "l": "L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48651", "l": "lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45684", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(in) = N-dodecanoyl-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50925", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0030343", "l": "vitamin D3 25-hydroxylase activity", "d": ["Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62368", "l": "Fe(2+)(out) + 2 hydrogencarbonate(out) = Fe(2+)(in) + 2 hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9835443", "l": "STAT1,STAT3 binds PKR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.378", "l": "\"L-rhamnose 1-dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21270", "l": "berberine + H(+) + 2 NADPH => (R)-canadine + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11150", "l": "4 Fe(3+) + 2 H2O => 4 Fe(2+) + 4 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72663", "l": "De novo formation of eIF2:GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043740", "l": "GTP cyclohydrolase IIa activity", "d": ["Catalysis of the reaction: GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H+ + 2 phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74948", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2-oxoglutarate + O2 => (3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66590", "l": "a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 26S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047673", "l": "anthranilate N-malonyltransferase activity", "d": ["Catalysis of the reaction: anthranilate + malonyl-CoA = N-malonylanthranilate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19804", "l": "(R)-4'-phosphopantetheine + ATP + H(+) <=> 3'-dephospho-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0016504", "l": "peptidase activator activity", "d": ["Binds to and increases the activity of a peptidase."], "t": []}, {"i": "REACT:R-HSA-168865", "l": "NA activation of TGF-beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607746", "l": "PKC-delta is activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0005313", "l": "L-glutamate transmembrane transporter activity", "d": ["Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56831", "l": "2,3,6-trichlorohydroquinone + chloride + glutathione disulfide <=> 2,3,5,6-tetrachlorohydroquinone + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938815", "l": "RNF152 polyubiquitinates RRAGA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67136", "l": "3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31662", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63066", "l": "3 CO2 + 4 CoA + tetraacetate lactone => acetyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78610", "l": "(3R)-hydroxyoctadecanoyl-CoA + NAD(+) <=> 3-oxooctadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375151", "l": "Interaction of NCAM1 with collagens (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176956", "l": "Formation of GINS complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199456", "l": "PTEN dephosphorylates PIP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050112", "l": "inositol 2-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28167", "l": "5-nitroanthranilate + H(+) + H2O => 5-nitrosalicylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102335", "l": "N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-N-acetyl-D-galactosamine = N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17284", "l": "(2S)-4-acetamido-2-aminobutanoate <=> H2O + L-ectoine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12903", "l": "D-ornithine + urea => D-arginine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254251", "l": "ERBB4s80 binds YAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34336", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9835189", "l": "NCK1 binds PKR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57527", "l": "a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O <=> a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0015204", "l": "urea transmembrane transporter activity", "d": ["Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12489", "l": "2-amino-2-deoxy-D-gluconate => 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22133", "l": "ATP + D-maltose(out) + H2O => ADP + D-maltose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72155", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696275", "l": "RND2 binds GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004072", "l": "aspartate kinase activity", "d": ["Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35121", "l": "bisdemethoxycurcumin + CO2 + 2 CoA => (4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43610", "l": "2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate => agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75244", "l": "FASL binds FAS Receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018497", "l": "Estrogen-responsive TFF3 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73686", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821368", "l": "AKAP8L binds MLL1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418856", "l": "Activation of Rac1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944232", "l": "Association of procollagen type XII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449978", "l": "IL7 binds IL7R:JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938887", "l": "PML binds RUNX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694527", "l": "Loss of SAR1B GTPase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004027", "l": "alcohol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140832", "l": "L-histidine, sodium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-histidine(out) + Na+(out) = H+(out) + L-histidine(in) + Na+(in)."], "t": []}, {"i": "RHEA:71135", "l": "H(+)(in) + L-histidine(out) + Na(+)(out) = H(+)(out) + L-histidine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12691", "l": "H(+) + mycothione + NADH => 2 mycothiol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0042030", "l": "ATPase inhibitor activity", "d": ["Binds to and stops, prevents or reduces an ATP hydrolysis activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38007", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49723", "l": "2 H(+) + NADH + 2 O2 + protoviolaceinate <=> CO2 + 2 H2O + NAD(+) + violacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45927", "l": "9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106239", "l": "9,13-epoxylabda-14-ene synthase activity", "d": ["Catalysis of the reaction:peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032093", "l": "SAM domain binding", "d": ["Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55952", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38401", "l": "(9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615042", "l": "Viral 2',5'-PDE cleaves 2'-5' oligoadenylates  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37339", "l": "3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O = (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694409", "l": "Nucleotide exchange on RAB1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52347", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate <=> (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250264", "l": "TXNIP binds reduced thioredoxin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34728", "l": "H2O + N-acyl-15-methylhexadecasphinganine => 15-methylhexadecasphinganine + a carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22902", "l": "diacetyl + H(+) + NADH => (R)-acetoin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852362", "l": "GTSE1 binds CDKN1A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870461", "l": "RABGGTA and RABGGTB bind (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77355", "l": "2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62579", "l": "ATP + H2O + L-cystine(out) <=> ADP + H(+) + L-cystine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019771", "l": "high-affinity IgG receptor activity", "d": ["Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22979", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31963", "l": "9beta-pimara-7,15-dien-19-al + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015608", "l": "carbohydrate-importing ABC transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) -> ADP + phosphate + carbohydrate(in)."], "t": []}, {"i": "TCDB:3.A.1.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68610", "l": "Formation of ORC(2-5) complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.154", "l": "\"ureidoglycolate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443418", "l": "GP1b signaling involves c-Src (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10236", "l": "trans-2-coumarate + UDP-alpha-D-glucose = H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.114", "l": "\"2-coumarate O-beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030506", "l": "ankyrin binding", "d": ["Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190261", "l": "FGFR3c binds to FGF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034875", "l": "caffeine oxidase activity", "d": ["Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41595", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH <=> 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28691", "l": "(S)-dihydroorotate + a ubiquinone = a ubiquinol + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984606", "l": "Kinesin-5 is a homotetramer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45568", "l": "[heparosan](n) = [acharan](n)", "d": [], "t": []}, {"i": "EC:5.1.3.36", "l": "\"heparosan-glucuronate 5-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52993", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine => [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9839110", "l": "HTRA2 degrades NDUFA13 (GRIM-19) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199583", "l": "KIR2DS2 interacting with HLA-C group 1 (Cw3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16058", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22880", "l": "2-oxoglutarate + L-arogenate = L-glutamate + prephenate", "d": [], "t": []}, {"i": "EC:2.6.1.79", "l": "\"glutamate--prephenate aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68538", "l": "(-)-alpha-cedrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75768", "l": "(9Z)-hexadecenoate + H2O => 10-hydroxyhexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733545", "l": "Bile salts and acids bind ALB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45396", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68356", "l": "H2O + N-acetyl-L-aspartyl-L-glutamate = L-glutamate + N-acetyl-L-aspartate", "d": [], "t": []}, {"i": "EC:3.4.17.21", "l": "\"glutamate carboxypeptidase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110213", "l": "NTHL1 glycosylase mediated recognition and binding of formamidopyrimidine (FapyA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50046", "l": "adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+) => an acyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008901", "l": "ferredoxin hydrogenase activity", "d": ["Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47355", "l": "a hexanoate ester + H2O <=> an aliphatic alcohol + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15262", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209921", "l": "Monoiodinated tyrosine can be deiodinated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67937", "l": "a 2-hydroxy carboxylate + O2 => a 2-oxocarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018538", "l": "epoxide carboxylase activity", "d": ["Catalysis of the generic reaction: epoxide + CO2 + NAD+ + electron donor = beta-keto acid + NADH + reduced electron donor; the electron donor may be NADPH or a dithiol. This reaction is the ring opening and carboxylation of an epoxide; for example: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870558", "l": "CDK5:p25 phosphorylates FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13570", "l": "a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => a beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047451", "l": "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + (2E)-octenoyl-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868071", "l": "Clathrin recruits PIK3C2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033876", "l": "glycochenodeoxycholate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-diphosphate + glycochenodeoxycholate 7-sulfate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14675", "l": "a polar amino acid(in) + ADP + H(+) + phosphate => a polar amino acid(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21719", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047139", "l": "glutathione-homocystine transhydrogenase activity", "d": ["Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73859", "l": "1-methylnicotinamide(out) = 1-methylnicotinamide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694471", "l": "Polyadenylation of SARS-CoV-2 genomic RNA (plus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55832", "l": "cortisone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44259", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015481", "l": "maltose transporting porin activity", "d": ["Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50558", "l": "H2O + prostaglandin J2 => prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33792", "l": "H2O + sucrose 6(F)-phosphate => beta-D-fructose + beta-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022399", "l": "ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169406", "l": "ISGylation of host proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174121", "l": "Association of Securin with Cdc20:APC/C complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560472", "l": "Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68686", "l": "adenosine 3',5'-bisphosphate + H(+) + testosterone 17-O-(3-sulfo-beta-D-glucuronate) => 3'-phosphoadenylyl sulfate + testosterone 17-O-(beta-D-glucuronate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56119", "l": "2-all-trans-decaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26488", "l": "L-cysteate + phosphate => H(+) + O-phospho-L-serine + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16821", "l": "6-phospho-D-gluconate + NAD(+) = 6-phospho-2-dehydro-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4167511", "l": "HLCS biotinylates ACACB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54235", "l": "1,2-dioctanoyl-sn-glycerol + CDP-choline <=> 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15448", "l": "H(+) + H2O + O-carbamoyl-L-serine <=> CO2 + 2 NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373024", "l": "isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34646", "l": "2 S-adenosyl-L-methionine + squalene <=> 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62799", "l": "H(+) + NADPH + O2 + 2 rubrofusarin B <=> aurasperone A + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917693", "l": "ESCRT Disassembly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30290", "l": "15-cis-phytoene + 2 a plastoquinone <=> 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5678327", "l": "MIOX oxidises Ins to GlcA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58707", "l": "rifampicin hemiaminal <=> rifampicin ortho-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38487", "l": "1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114354", "l": "SMAC binds XIAP:Caspase-7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.71", "l": "\"adenosine-5'-diphospho-5'-[DNA] diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140954", "l": "histone H3K36 dimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl36-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl36-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805122", "l": "AURKB binds TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48114", "l": "H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15379", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+) => (S)-4,5-dihydroxypentane-2,3-dione + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34281", "l": "di-trans,cis-polyprenol + H(+) + NADPH => di-trans,poly-cis-dolichol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40865", "l": "FADH2 + trans-2-heptadecenoyl-CoA => FAD + H(+) + heptadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382053", "l": "Translocation of PDGF from ER to Golgi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76429", "l": "(2R)-annullatin F + AH2 => (2R,9S)-annullatin H + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47004", "l": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13499", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+) => 5-dehydro-2-deoxy-D-gluconate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51946", "l": "2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine => 8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182286", "l": "Transport of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40655", "l": "(R)-malate + succinyl-CoA = (R)-malyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17357", "l": "O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'", "d": [], "t": []}, {"i": "EC:1.8.3.2", "l": "\"thiol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53822", "l": "7-oxolithocholate + H(+) + NADPH => chenodeoxycholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.98.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37089", "l": "3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17750", "l": "A + H2O + quinoline => AH2 + quinolin-2(1H)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944232", "l": "Association of procollagen type XII (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40718", "l": "dihydroxyacetone phosphate + hexadecanoyl-CoA <=> 1-hexadecanoylglycerone 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0050236", "l": "pyridoxine:NADP 4-dehydrogenase activity", "d": ["Catalysis of the reaction: NADP+ + pyridoxine = H+ + NADPH + pyridoxal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68672", "l": "16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 16alpha,17beta-estriol 16-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43635", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) <=> an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24079", "l": "a 3beta-hydroxy-Delta(5)-steroid + NAD(+) <=> a 3-oxo-Delta(5)-steroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33317", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798257", "l": "PTPRS binds NTRK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68758", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine => 4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391941", "l": "BLT receptors can bind LTB4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10675", "l": "cyclobutadithymidine in DNA <=> a thymidine dimer in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799097", "l": "ATM phosphorylates ZNF420 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34602", "l": "15-methylhexadecasphinganine + NADP(+) <=> 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67448", "l": "(2R)-2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74072", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24301", "l": "2 cob(I)yrinate a,c diamide + FMN + 3 H(+) => 2 cob(II)yrinate a,c diamide + FMNH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10391", "l": "GTP + oxaloacetate <=> CO2 + GDP + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211247", "l": "Cleavage of DNA by DFF40 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36581", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH => dTDP-alpha-D-fucose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55015", "l": "(1S,4R)-1-hydroxylimonen-2-one + NADPH + O2 <=> (3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156682", "l": "PLK1 phosphorylates NUDC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61305", "l": "N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose => H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78015", "l": "a 1,2-diacylglycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35819", "l": "5,6,7,8-tetrahydromethanopterin + NADP(+) = 7,8-dihydromethanopterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106367", "l": "(deoxy)nucleoside phosphate kinase activity, dGTP as phosphate donor", "d": ["Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP."], "t": []}, {"i": "RHEA:62128", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68014", "l": "H2O2 + xanthine => H2O + hypoxanthine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66919", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12422", "l": "ADP + D-tagatofuranose 1,6-bisphosphate + H(+) => ATP + D-tagatofuranose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78504", "l": "2-oxoglutarate + 3-(N-acetyl-N-hydroxy)aminopropylphosphonate + O2 => (R)-(3-(acetylhydroxyamino)-2-hydroxypropyl)phosphonate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41778", "l": "CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+) => CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-517674", "l": "p-S158,221-HuR binds mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788628", "l": "p-Y-STATs dissociate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38513", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814831", "l": "TBC1D20 binds RAB1:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696547", "l": "STAMBPL1 is a deubiquitinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839367", "l": "TGFBR3_mem cleavage by MMPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75891", "l": "Abortive Initiation After Second Transition (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984671", "l": "Chromokinesins form dimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37724", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102888", "l": "delta-cuprenene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = delta-cuprenene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11770", "l": "5-phospho-alpha-D-ribose 1-diphosphate + anthranilate => diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16811", "l": "pyruvate + succinate => (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008240", "l": "NFE2 is a heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177923", "l": "Sustained activation of SRC kinase by SHP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55982", "l": "an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+) => a 1,2-saturated acyl-CoA + an acyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74734", "l": "Re-integration of insulin receptor into plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351412", "l": "Association of MRE11 and NBS1 leads to nuclear localization of MRN complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388900", "l": "Neurotensin receptors can bind neurotensins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134953", "l": "DHX36 or DHX9 binds MyD88 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427570", "l": "Group 3 - Selective Cl- transport (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473594", "l": "Collagen type II degradation by MMP15 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964588", "l": "CCNA2 gene expression is inhibited by RBL1 and RBL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008404", "l": "arachidonic acid 14,15-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid."], "t": []}, {"i": "RHEA:51472", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102637", "l": "5-aminolevulinate-CoA ligase activity", "d": ["Catalysis of the reaction: 5-ammoniolevulinate + coenzyme A + ATP = 5-aminolevulinyl-CoA + AMP + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36897", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O => (9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37519", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854462", "l": "VLDLR binds VLDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38474", "l": "L-histidine + 3 S-adenosyl-L-methionine <=> 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35869", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44160", "l": "1D-myo-inositol 6-phosphate + H2O = myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37407", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13632", "l": "(1S,5R)-carveol + NADP(+) <=> (R)-carvone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0003714", "l": "transcription corepressor activity", "d": ["A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53060", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672948", "l": "MARK3 phosphorylates KSR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29368", "l": "CMP + H2O => cytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388900", "l": "Neurotensin receptors can bind neurotensins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57917", "l": "ATP + L-aspartyl-tRNA(Asn) => 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22629", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate => (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682709", "l": "LGI4 binds ADAM22,23,11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034598", "l": "phosphothreonine lyase activity", "d": ["Catalysis of the removal of the phosphate group from phosphothreonine by cleavage of the C-OP bond with the concomitant abstraction of the alpha proton, generating a double bond-containing product."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40695", "l": "1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol = 1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794444", "l": "ALB binds Cipro (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55129", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] => (2E)-5-methylhexenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66474", "l": "18-episcalar-17(25)-en-19-ol => (2Z,6E,10E,14E)-geranylfarnesol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42117", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703442", "l": "Phosphorylated FLT3 fusions bind GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9761421", "l": "CDH11 associates with catenins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004773", "l": "steryl-sulfatase activity", "d": ["Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043894", "l": "acetyl-CoA synthetase acetyltransferase activity", "d": ["Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10347", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12921", "l": "glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO2 + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.37", "l": "\"5-aminolevulinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388811", "l": "CD28 homodimer binds B7-1 homodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803890", "l": "SFN dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.38", "l": "\"gametolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59686", "l": "D-maltohexaono-1,5-lactone + H2O2 => D-maltohexaose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26346", "l": "L-galactonate + NADP(+) => aldehydo-D-galacturonate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18470", "l": "an acyl-CoA + L-glutamine => an N(2)-acyl-L-glutamine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70914", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 6-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63994", "l": "5-fluorocytidine 5'-phosphate + ADP + H(+) => 5-fluorocytidine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805103", "l": "AURKA phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21143", "l": "ATP + inosine <=> ADP + H(+) + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43030", "l": "2-aminoprop-2-enoate + H(+) + sulfite => L-cysteate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60796", "l": "2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 = 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25217", "l": "acetyl-CoA + serotonin = CoA + H(+) + N-acetylserotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210271", "l": "Interaction of DAP12 and MDL-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218806", "l": "FYN autophosphorylates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666428", "l": "DOCK180 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37997", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate => all-trans-nonaprenyl diphosphate + H(+) + homogentisate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30246", "l": "4 L-ascorbate + O2 <=> 2 H2O + 4 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71325", "l": "chloride(in) + L-asparagine(in) + 2 Na(+)(in) => chloride(out) + L-asparagine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71808", "l": "a 2'-deoxyguanosine in DNA + NAD(+) => an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215295", "l": "USP7 deubiquitinates MDM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79076", "l": "(4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside + UDP-alpha-D-glucuronate => (4Z,15Z)-bilirubin IXalpha C8,C12-beta-D-bisglucuronoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56162", "l": "an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP => an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734687", "l": "ORC6 is phosphorylated on T195 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67084", "l": "ATP + H2O + hexacosanoate(in) = ADP + H(+) + hexacosanoate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20577", "l": "3-hydroxyaminophenol = aminohydroquinone", "d": [], "t": []}, {"i": "EC:5.4.4.3", "l": "\"3-(hydroxyamino)phenol mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32407", "l": "(1R,2S,4S)-neoisodihydrocarveol + NAD(+) = (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73800", "l": "dimethylallyl diphosphate + isoechinulin A => dehydroechinulin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39392", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH => (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.3.-", "l": "\"Cyclo-ligases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874979", "l": "ACBD3 binds GOLGB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046703", "l": "natural killer cell lectin-like receptor binding", "d": ["Binding to a lectin-like natural killer cell receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38480", "l": "N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine => H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29737", "l": "butanal + FMN + 2 H(+) + H2O + sulfite => butane-1-sulfonate + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49516", "l": "2-oxoglutarate + an N(1)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.54", "l": "\"mRNA N(1)-methyladenine demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004604", "l": "phosphoadenylyl-sulfate reductase (thioredoxin) activity", "d": ["Catalysis of the reaction: adenosine 3',5'-diphosphate + H+ + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46310", "l": "17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734745", "l": "Defective ADA does not deaminate (deoxy)adenosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29830", "l": "Mg(2+)(in) <=> Mg(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70451", "l": "2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2 = a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199910", "l": "MSK1 activates ATF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.70", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38193", "l": "17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50535", "l": "acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70997", "l": "SUCLG1/A2 cleaves succinyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28545", "l": "fluoroacetyl-CoA + H2O <=> CoA + fluoroacetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58593", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41420", "l": "2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 = CO2 + grixazone B + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31287", "l": "H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA = acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604763", "l": "Autocatalytic activation of MMP7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429714", "l": "CSNK1G2 phosphorylates p-CERT1-2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9005980", "l": "IL21 binds IL21R:JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78636", "l": "3-oxohexacosanoyl-CoA + H(+) + NADH => (3R)-hydroxyhexacosanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60720", "l": "(E)-hept-2-enal + H2O + NADP(+) = (E)-hept-2-enoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36053", "l": "2 beta-L-arabinofuranose => beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39564", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH => (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37490", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine <=> 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43058", "l": "10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+) => 5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.77", "l": "\"alkyl sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102930", "l": "4-hydroxybenzoate geranyltransferase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + 4-hydroxybenzoic acid = 3-geranyl-4-hydroxybenzoate + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51353", "l": "H2O + N-(9Z-octadecenoyl)-L-serine => (9Z)-octadecenoate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38158", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (6E,10E)-geranyllinalool + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0052890", "l": "oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin."], "t": []}, {"i": "EC:1.3.8.-", "l": "\"With a flavin as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21420", "l": "NADP(+) + prostaglandin I2 = 15-dehydro-prostaglandin I2 + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.231", "l": "\"15-hydroxyprostaglandin-I dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428534", "l": "Recruitment of Profilin by Ena/VASP proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37926", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20046", "l": "3-oxopropanoate + H2O + NAD(+) => 2 H(+) + malonate + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16050", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole => adenosylcob(III)alamin + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030790", "l": "chlorophenol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9714363", "l": "RHOC translocates to the endoplasmic reticulum membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26023", "l": "8'-apo-beta-carotenol + O2 = (3E,5E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal", "d": [], "t": []}, {"i": "EC:1.13.11.67", "l": "\"8'-apo-beta-carotenoid 14',13'-cleaving dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381668", "l": "cAMP activates EPAC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18266", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) => 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1170539", "l": "Prolactin receptor is internalized (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45880", "l": "3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2059926", "l": "NPHP4 protein binds LATS proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50718", "l": "FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate => dimethyl sulfone + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27807", "l": "acetoacetate + acetyl-CoA => acetate + acetoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848339", "l": "PNPLA5 hydrolyzes TAG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47200", "l": "(24S)-7alpha-dihydroxycholesterol + NAD(+) = (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0052616", "l": "ent-kaur-16-en-19-ol oxidase activity", "d": ["Catalysis of the reaction: H+ + NADPH + ent-kaur-16-en-19-ol + oxygen = 2 H2O + NADP+ + ent-kaur-16-en-19-al."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5600598", "l": "Defective CYP11B2 does not oxidise 11DCORST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0005214", "l": "structural constituent of chitin-based cuticle", "d": ["The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50249", "l": "ATP + D-ribose 5-phosphate + H(+) => ADP-D-ribose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15306", "l": "betaine aldehyde + H2O + NAD(+) => glycine betaine + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52476", "l": "estrone + UDP-alpha-D-glucuronate = estrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806610", "l": "Keratin filament formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36002", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102518", "l": "(11Z)-eicosenoate 14-hydroxylase activity", "d": ["Catalysis of the reaction: (11Z)-eicosenoyl-CoA + NADH + O2 + H+ = lesqueroloyl-CoA + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72719", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-[(R)-dihydrolipoyl]-5'-AMP = AMP + 2 H(+) + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58068", "l": "(E)-isoeugenol + O2 = acetaldehyde + vanillin", "d": [], "t": []}, {"i": "EC:1.13.11.88", "l": "\"isoeugenol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64790", "l": "(E)-cinnamoyl-CoA + AMP + diphosphate => (E)-cinnamate + ATP + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19171", "l": "NH4(+) + pyruvate => L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693347", "l": "CRYM reduces P2C to PPCA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10843", "l": "H2O + O-phospho-L-homoserine <=> L-threonine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39580", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA => (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53645", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-corvol ether B + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2317531", "l": "SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001591", "l": "dopamine neurotransmitter receptor activity, coupled via Gi/Go", "d": ["Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51841", "l": "2 Na(+)(out) + tauroallocholate(out) => 2 Na(+)(in) + tauroallocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22540", "l": "5'-dehydroadenosine + H2O + O2 = 9-riburonosyladenine + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39084", "l": "3-oxododecanedioyl-CoA + CoA => acetyl-CoA + decanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48823", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 <=> 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047682", "l": "aryl-alcohol oxidase activity", "d": ["Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60294", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41288", "l": "H2O + N-tetradecanoylsphing-4-enine => sphing-4-enine + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42704", "l": "hercynine + L-cysteine + O2 = H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": [], "t": []}, {"i": "EC:1.21.3.10", "l": "\"hercynylcysteine S-oxide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68610", "l": "Formation of ORC(2-5) complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77654", "l": "2 [4-(deca-1,8-diyl)-2,5-dioxo-2,5-dihydro-3-furanyl]acetate + H(+) <=> 2-[(1R,8S,14R,15R)-11-hydroxy-14,15-bis[(6E)-oct-6-en-1-yl]-3,5,9-trioxo-4,10-dioxatetracyclo[9.4.0.0(2,6).0(8,12)]pentadeca-2(6),12-dien-8-yl]acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12400", "l": "beta-nicotinamide D-ribonucleotide + H2O = NH4(+) + nicotinate beta-D-ribonucleotide", "d": [], "t": []}, {"i": "EC:3.5.1.42", "l": "\"nicotinamide-nucleotide amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036217", "l": "dGTP diphosphatase activity", "d": ["Catalysis of the reaction: dGTP + H2O = dGMP + H+ + diphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51515", "l": "H2O + oxamate <=> NH4(+) + oxalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933258", "l": "LSR trimer binds LDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40457", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55974", "l": "CoA + ethyl acetate => acetyl-CoA + ethanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.5.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74716", "l": "Insulin binds the insulin receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951676", "l": "RUNX3 binds TEADs and YAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617583", "l": "CaMKII autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693125", "l": "RHOF binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42297", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] => a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51677", "l": "[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide => [protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392749", "l": "Transport of L1 into endosomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76710", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione <=> (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160004", "l": "poly-ADP-D-ribose modification-dependent protein binding", "d": ["Binding to a protein upon poly-ADP-ribosylation of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76897", "l": "2-hexyl-5-(5-hydroxypentyl)resorcinol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-hexyl-5-pentylresorcinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204779", "l": "Interaction of Tie2 with Ang1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65502", "l": "5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-oxopyrrolidin-3-yl}acetamide + A + H(+) + L-methionine => [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + AH2 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014296", "l": "RAC2 GEFs activate RAC2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112392", "l": "Resumption of elongation after recovery from pausing (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112429", "l": "Formation of FACT complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65631", "l": "sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432897", "l": "ILK interacts with beta-1 integrin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62812", "l": "4 monapinone A + O2 = 2 dinapinone A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22896", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.86", "l": "\"fatty-acyl-CoA synthase system\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-994148", "l": "LRRC16A binds F-actin capping protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78647", "l": "ATP + S-sulfanyl-L-cysteine + tRNA(Cys) = (S)-sulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937369", "l": "ATAD2 binds ESR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23808", "l": "(S)-scoulerine + S-adenosyl-L-methionine = (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.117", "l": "\"(S)-scoulerine 9-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854981", "l": "SHC1 in the RET complex is phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875531", "l": "MET binds TNS4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376122", "l": "DSCAM/DSCAML1 homodimerization (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034817", "l": "cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-9,10-dihydroanthracene-9,10-diol = 9,10-anthraquinone + 4 H+ + 4 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954199", "l": "CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58536", "l": "glycine + hexadecanoyl-CoA = CoA + H(+) + N-hexadecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72088", "l": "2 Na(+)(out) + taurodeoxycholate(out) => 2 Na(+)(in) + taurodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69794", "l": "D-phenylalanyl-tRNA(Phe) + H2O <=> D-phenylalanine + H(+) + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202500", "l": "Activation of IKK complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44517", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871226", "l": "RET binds GFRA1,GFRA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67382", "l": "L-alanine + L-cysteine => H2O + L-alanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654163", "l": "Activated FGFR4 binds PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870466", "l": "RGGT:CHM binds RABs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0016793", "l": "triphosphoric monoester hydrolase activity", "d": ["Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018497", "l": "1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity", "d": ["Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47293", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818682", "l": "MEN1 binds MLL2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73044", "l": "creatine(in) => creatine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31998", "l": "(2E,6E)-farnesyl diphosphate <=> 7-epi-sesquithujene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672170", "l": "SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.4", "l": "\"phospholipase D\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691131", "l": "CANDI binds CUL1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74958", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + holo-[ACP] <=> a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42968", "l": "cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.206", "l": "\"tRNA (cytidine(56)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75778", "l": "(6Z,9Z,12Z)-octadecatrienoate + H2O <=> (10S)-hydroxy-(6Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47187", "l": "5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45249", "l": "butanoate(out) => butanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57106", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2) => [(1->4)-alpha-D-galacturonosyl](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61185", "l": "quercitrin + UDP-beta-L-rhamnose => H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66973", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose => alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928614", "l": "EFNB:GRB4 binds GIT1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218814", "l": "PAK2 autophorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46632", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + NADPH = 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807077", "l": "NR2E1 associated with transcription repressors binds PTEN promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877902", "l": "Activated AR binds RUNX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210881", "l": "Dimerization of Tie2/Ang1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001665", "l": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018530", "l": "(R)-6-hydroxynicotine oxidase activity", "d": ["Catalysis of the reaction: (R)-6-hydroxynicotine + H2O + O2 = 6-hydroxypseudooxynicotine + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36684", "l": "hexadecanoyl-CoA + L-cysteinyl-[protein] => CoA + S-hexadecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25000", "l": "H(+) + N,N-dihydroxy-L-phenylalanine = (E)-phenylacetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63348", "l": "ATP + L-amino acyl-L-cysteinyl-[protein] = (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63199", "l": "(10bR,4aS)-noroxomaritidine + H(+) + NADPH <=> (10bR,4aS)-oxomaritidine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55494", "l": "ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57213", "l": "dGTP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216941", "l": "Phosphorylation of Chk1 by ATR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.50", "l": "\"3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66627", "l": "cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592387", "l": "Fibulin binds elastic fibres (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18663", "l": "H(+) + L-ornithine + NADPH + pyruvate => H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77838", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-glutamate + O2 <=> (2S)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]pentanedioate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1222491", "l": "Lactoferrin scavenges iron ions (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692250", "l": "WT1, NR5A1 (SF1), GATA4, ZFPM2 bind the SRY gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168848", "l": "tBID binds to inactive BAK protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874209", "l": "CREB3L4 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60747", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone <=> CoA + pyrethrin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102780", "l": "sitosterol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + sitosterol + O2 + NADPH = (22alpha)-hydroxy-sitosterol + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678920", "l": "TLR processing at low pH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11738", "l": "6-oxocineole + H(+) + NADH => 2-exo-hydroxy-1,8-cineole + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30566", "l": "dimethylallyl diphosphate + L-tryptophan <=> 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34892", "l": "selenite(in) => selenite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68916", "l": "ATP + butanoate + H(+) + NADPH = AMP + butanal + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28642", "l": "(2Z,6E)-farnesyl diphosphate <=> (-)-gamma-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69154", "l": "acrolein + spermidine => spermine monoaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60281", "l": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55078", "l": "3-methylsulfanylpropanal + CO2 => 4-methylsulfanyl-2-oxobutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0042294", "l": "URM1 transferase activity", "d": ["Catalysis of the transfer of URM1 from one protein to another via the reaction X-URM1 + Y = Y-URM1 + X, where both X-URM1 and Y-URM1 are covalent linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102182", "l": "4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol dehydrogenase/C4-decarboxylase activity", "d": ["Catalysis of the reaction: 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD = avenastenone + NADH + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15754", "l": "GTP + IMP + L-aspartate => GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37367", "l": "CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine = 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55459", "l": "ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56086", "l": "[Rab1 protein]-L-serine + H(+) + phosphocholine => [Rab1 protein]-O-phosphocholine-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854303", "l": "TBC1D11 binds RAB6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018721", "l": "trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity", "d": ["Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693243", "l": "RHOD translocates to the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30363", "l": "fumonisin B1 + 2 H2O = (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate", "d": [], "t": []}, {"i": "EC:3.1.1.87", "l": "\"fumonisin B1 esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033456", "l": "GCG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GCG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61028", "l": "itaconate + L-cysteinyl-[protein] = S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0001227", "l": "DNA-binding transcription repressor activity, RNA polymerase II-specific", "d": ["A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416698", "l": "SEMA5A binds to PLXNB3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54184", "l": "an N-acyl-aromatic L-alpha-amino acid + H2O = a carboxylate + an aromatic L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31020", "l": "4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 => 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61338", "l": "ADP + H(+) + phosphate + protoporphyrin IX(out) => ATP + H2O + protoporphyrin IX(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46772", "l": "1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.28", "l": "\"sn-1 stearoyl-lipid 9-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65775", "l": "2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50310", "l": "11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29674", "l": "Ca(2+)(in) <=> Ca(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809793", "l": "MTMR2 binds SBF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371567", "l": "DBC1 is phosphorylated by ATM/ART (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114558", "l": "Thrombin-activated PARs activate Gq (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19318", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate => 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64072", "l": "acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA = 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645598", "l": "RRAGC,D hydrolyzes GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24081", "l": "ATP + L-tryptophan + tRNA(Trp) => AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36506", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + malonyl-CoA <=> (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56439", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686088", "l": "CASP3 cleaves GSDMD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71310", "l": "chloride(out) + L-valine(out) + 2 Na(+)(out) <=> chloride(in) + L-valine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432424", "l": "JET binds phosphorylated nuclear TIM, facilitating its ubiquitination (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19623", "l": "a nucleoside 3'-phosphate + H(+) => a nucleoside 2',3'-cyclic phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32296", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH => 2 diphosphate + NADP(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66650", "l": "african-3-ene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430183", "l": "NCK binds PAK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68719", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + germacrene D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34455", "l": "all-trans-beta-carotene = 9-cis-beta-carotene", "d": [], "t": []}, {"i": "EC:5.2.1.14", "l": "\"beta-carotene isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9854672", "l": "FAD attaches to SDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70379", "l": "3-oxosphinganine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247497", "l": "ERBB3 binds neuregulins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32374", "l": "all-trans-violaxanthin + 2 L-ascorbate <=> all-trans-zeaxanthin + 2 H2O + 2 L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27309", "l": "A + D-proline <=> 1-pyrroline-2-carboxylate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23050", "l": "(R)-2-hydroxyglutarate + acetoacetate => (S)-3-hydroxybutanoate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20822", "l": "choline + H(+) + sulfate => choline sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59641", "l": "D-xylotetraose + O2 => D-xylotetraono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661230", "l": "MT1A binds arsenic (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033154", "l": "ABC-type oligogalacturonide transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in)."], "t": []}, {"i": "TCDB:3.A.1.1.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164514", "l": "Integrase binds viral DNA ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209828", "l": "Tryptophan is hydroxylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.1", "l": "\"rubredoxin--NAD(+) reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59516", "l": "acetylsalicylate + L-lysyl-[protein] = H(+) + N(6)-acetyl-L-lysyl-[protein] + salicylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372980", "l": "succinylCoA + GDP + Pi <=> succinate + CoASH + GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416562", "l": "p190RhoGAP binds Plexin-B1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63905", "l": "2 3-phenylpyruvate + H(+) => H2O + phenguignardate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61734", "l": "H(+) + steviolmonoside + UDP => steviol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53564", "l": "9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30936", "l": "H2O + nicotinate beta-D-ribonucleotide => beta-D-ribosylnicotinate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47732", "l": "cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73503", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine = 3',4,7-trihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35767", "l": "dihydrosterigmatocystin + S-adenosyl-L-methionine = 8-O-methyldihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25518", "l": "CoA + H(+) + O-acyltropine => an acyl-CoA + tropine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140775", "l": "actin filament debranching activity", "d": ["Binding to an actin filament and promoting the dissociation of an actin filament branch."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74761", "l": "3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine => isorhamnetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47090", "l": "3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032441", "l": "pheophorbide a oxygenase activity", "d": ["Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38022", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol <=> 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45511", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58170", "l": "(-)-5-epi-eremophilene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450054", "l": "Interleukin-2 receptor alpha binds interleukin-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48299", "l": "H2O + prostaglandin E2 1-glyceryl ester <=> glycerol + H(+) + prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57502", "l": "2-methyl-cis-aconitate + H2O => 3-hydroxybutane-1,2,3-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45337", "l": "(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine => [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033421", "l": "CCU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CCU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50443", "l": "prostaglandin H1 <=> prostaglandin D1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42632", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.224", "l": "\"23S rRNA (adenine(2503)-C(8))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21000", "l": "1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene", "d": [], "t": []}, {"i": "EC:1.97.1.2", "l": "\"pyrogallol hydroxytransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57049", "l": "AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783670", "l": "CRLF1 binds CLCF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53387", "l": "5,10-methylenetetrahydromethanopterin + NAD(+) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5229283", "l": "LCNs bind lipids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67403", "l": "(2E,6E)-farnesyl diphosphate <=> allo-aromadendrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17578", "l": "ADP-D-glycero-beta-D-manno-heptose => ADP-L-glycero-beta-D-manno-heptose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47373", "l": "a quinone + D-glucose => a quinol + D-glucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1470009", "l": "Phosphorylation of STATs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24386", "l": "AMP + diphosphate + H(+) + L-glutamate + NAD(+) => ATP + deamido-NAD(+) + H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755244", "l": "SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782890", "l": "LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74409", "l": "2 (S)-lactate(out) + thromboxane B2(in) => 2 (S)-lactate(in) + thromboxane B2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264865", "l": "Caspase-mediated cleavage of Lamin A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38684", "l": "ATP + H2O + sphing-4-enine(in) => ADP + H(+) + phosphate + sphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75484", "l": "estrone 3-sulfate(out) + n H(+)(out) => estrone 3-sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19820", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30184", "l": "L-galactonate + NAD(+) => H(+) + keto-D-tagaturonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990882", "l": "CDK1 phosphorylates NUP98 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60991", "l": "(E)-hex-2-en-1-ol + NAD(+) <=> (E)-hex-2-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25942", "l": "8-chloroquinolin-2(1H)-one + AH2 => 8-chloroquinoline + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61622", "l": "[(1->2)-beta-D-mannosyl](n+1) + GDP + H(+) => [(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25556", "l": "9alpha-copalyl diphosphate = diphosphate + stemod-13(17)-ene", "d": [], "t": []}, {"i": "EC:4.2.3.34", "l": "\"stemod-13(17)-ene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17474", "l": "GTP + H2O => 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655833", "l": "Expression of TM7SF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869683", "l": "oxPL binds LBP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23174", "l": "ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] => ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16559", "l": "2-aminomuconate 6-semialdehyde + CO2 => 2-amino-3-carboxymuconate 6-semialdehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682388", "l": "Autophagosome maturation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69806", "l": "ATP + benzoate + H(+) <=> benzoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69404", "l": "uracil(in) = uracil(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66916", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47226", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28227", "l": "(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37775", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68859", "l": "(2Z,6E)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1972385", "l": "ADP-Ribosylation of HNP-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850831", "l": "KLK5 cleaves and activates KLK8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33423", "l": "N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out) = diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.196", "l": "\"protein-N(pi)-phosphohistidine--N,N'-diacetylchitobiose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75959", "l": "(S)-scoulerine + 2-oxoglutarate + O2 = (S)-3-O-demethylscoulerine + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.48", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201639", "l": "Caspase-mediated cleavage of GAS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17391", "l": "D-ribulose + H(+) + NADH => D-arabinitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52325", "l": "2 L-arginine + 4 O2 + 3 reduced [flavodoxin] => 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9824995", "l": "GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38636", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928584", "l": "p-EPHs bind SRC,FYN,YES,LYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23348", "l": "(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.44", "l": "\"4-carboxymuconolactone decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9032798", "l": "DOCK3 activates RAC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854209", "l": "TBC1D10A binds JFC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14207", "l": "anserine + H(+) + S-adenosyl-L-homocysteine => carnosine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165162", "l": "Phosphorylation of TSC2 by PKB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5099899", "l": "WNT5A binds FZD4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29620", "l": "alpha-maltotetraose + beta-maltose => alpha-maltopentaose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633414", "l": "TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177942", "l": "EGFR binds EGF ligand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102483", "l": "scopolin beta-glucosidase activity", "d": ["Catalysis of the reaction: H2O + scopolin = beta-D-glucose + scopoletin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47739", "l": "cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75878", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46420", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68887", "l": "3-hydroxybenzoate + ATP + H(+) + NADPH <=> 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60605", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56856", "l": "A + an aldehyde + H2O = a carboxylate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634418", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647978", "l": "pro-RAS proteins are farnesylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44219", "l": "12-hydroxyoctadecanoate + ATP + CoA <=> 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57507", "l": "3-hydroxybutane-1,2,3-tricarboxylate <=> pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5432825", "l": "HMGB1 binds TLR4:LY96 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35536", "l": "cyclo(L-phenylalanyl-L-leucyl) + O2 => cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34546", "l": "N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944454", "l": "mTORC1 phosphorylates MAF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58660", "l": "a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14099", "l": "L-phenylalanine + oxaloacetate => 3-phenylpyruvate + L-aspartate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68034", "l": "(3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+) => (S)-cystathionine ketimine + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936963", "l": "IRAK2 induces TRAF6 oligomerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38650", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43607", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] <=> 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50364", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-nandinine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.73", "l": "\"(S)-nandinine synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73751", "l": "(R)-adrenaline(in) + 2 H(+)(out) = (R)-adrenaline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4608855", "l": "PRICKLE1 is degraded by the proteasome (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25640", "l": "H2O + NAD(+) + sulfoacetaldehyde <=> 2 H(+) + NADH + sulfoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216051", "l": "Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1 bind laminin-111 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50961", "l": "cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13360", "l": "3-hydroxypropanoate + NAD(+) <=> 3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63013", "l": "(2E,6E)-farnesyl diphosphate + orsellinate => diphosphate + ilicicolinate B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20117", "l": "ATP + L-rhamnulose = ADP + H(+) + L-rhamnulose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.5", "l": "\"rhamnulokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66850", "l": "2 Cu(+) + H(+) + NAD(+) => 2 Cu(2+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51174", "l": "5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.17", "l": "\"corrinoid adenosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852362", "l": "GTSE1 binds CDKN1A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610723", "l": "GLI proteins bind SUFU (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63003", "l": "(11Z,14Z,17Z)-eicosatrienamide + H2O <=> (11Z,14Z,17Z)-eicosatrienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15978", "l": "(S)-4-hydroxymandelonitrile => 4-hydroxybenzaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74311", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391913", "l": "FPR2 binds FPR2 ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.472488299857119", "identifiers": [{"i": "GO:1901505", "l": "carbohydrate derivative transmembrane transporter activity", "d": ["Enables the transfer of carbohydrate derivative from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951486", "l": "CD46 binds C4b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31138", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate <=> 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58688", "l": "NADH + O2 + rifamycin SV = H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71590", "l": "(S)-malate(in) + 2-oxoglutarate(out) <=> (S)-malate(out) + 2-oxoglutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106076", "l": "peptide-lysine-N-succinyltransferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + lysine in peptide = CoA + N-succinyl-lysine-peptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0015278", "l": "intracellularly gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts."], "t": []}, {"i": "REACT:R-HSA-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0070679", "l": "inositol 1,4,5 trisphosphate binding", "d": ["Binding to inositol 1,4,5 trisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31035", "l": "arabidiol = (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.124", "l": "\"arabidiol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22920", "l": "L-glutamine + scyllo-inosose = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate", "d": [], "t": []}, {"i": "EC:2.6.1.50", "l": "\"glutamine--scyllo-inositol transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17991", "l": "ADP + H(+) + O-phospho-L-seryl-[protein] => ATP + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39295", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29060", "l": "2 H(+)(in) + H2 + ubiquinone-8 => 2 H(+)(out) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74711", "l": "Phosphorylation of IRS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768829", "l": "SRF stimulates NPAS4 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25111", "l": "ATP + pyridoxine <=> ADP + H(+) + pyridoxine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0043531", "l": "ADP binding", "d": ["Binding to ADP, adenosine 5'-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33261", "l": "N-formimidoylglycine + NH4(+) => 4-aminoimidazole + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617815", "l": "BBSome binds RAB3IP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34498", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43371", "l": "dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800298", "l": "HGF dimer binds MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48123", "l": "a ganglioside GD3 + H2O <=> a ganglioside GM3 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67590", "l": "a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+) => a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.27", "l": "\"coagulation factor XIa\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161666", "l": "PGA2 is isomerised to PGC2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24696", "l": "(E)-coniferyl acetate + NADPH => (E)-isoeugenol + acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42316", "l": "a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.2.7.11", "l": "\"2-oxoacid oxidoreductase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43935", "l": "3beta-hydroxyandrost-5-en-17-one + NAD(+) <=> androst-5-ene-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549322", "l": "OCT1 transports organic cations out of hepatic cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69836", "l": "campesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9627078", "l": "XIAP binds CASP9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857686", "l": "FITM1, FITM2 bind TAGs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41248", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008336", "l": "gamma-butyrobetaine dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O2 = carnitine + CO2 + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56502", "l": "CO2 + isopentenyl phosphate + phosphate => (R)-3,5-bisphosphomevalonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16984", "l": "3-oxoadipate + NAD(+) <=> H(+) + maleylacetate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418904", "l": "A1 and A3 receptors bind adenosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008768", "l": "UDP-sugar diphosphatase activity", "d": ["Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013021", "l": "GDIs block activation of RHOB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2077421", "l": "FP-1039 acts as a ligand-trap for FGFR2b-binding ligands in endometrial cancer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27762", "l": "CTP + H2O = CMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004765", "l": "shikimate kinase activity", "d": ["Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49295", "l": "D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] <=> 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483186", "l": "PC is converted to PS by PTDSS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24211", "l": "1,5-anhydro-D-mannitol + NADP(+) <=> 1,5-anhydro-D-fructose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.42", "l": "\"Kdo2-lipid A phosphoethanolamine 7''-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013159", "l": "CDC42 GEFs activate CDC42 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070644", "l": "vitamin D response element binding", "d": ["Binding to a vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48124", "l": "a ganglioside GD3 (d18:1(4E)) + H2O = a ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78454", "l": "a globoside Gb3Cer + H2O <=> a fatty acid + a lysoGb3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162253", "l": "PDSS1,2 ligates FPP to IPPP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11028", "l": "ATP + D-mannose = ADP + D-mannose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111956", "l": "Calmodulin activates Cam-PDE 1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36568", "l": "GDP-beta-L-colitose + NAD(+) => GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57990", "l": "(20S)-ginsenoside F2 + H(+) + UDP => (20S)-ginsenoside Rh2 + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48104", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35414", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside <=> an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693540", "l": "MRN activates ATM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803719", "l": "TP53 binds ZNF385A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432593", "l": "Cytosolic JET binds to CRY, facilitating its ubiquitination (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688786", "l": "ATXN3 binds RAD23 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786190", "l": "CMBL hydrolyses OM to OLMS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42554", "l": "pseudouridine(31) in tRNA => uridine(31) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3204311", "l": "AOX1 oxidises PXL to PDXate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12389", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44530", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418456", "l": "cGMP is degraded by PDEs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35266", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160125", "l": "pH-gated sodium channel activity", "d": ["A gated channel activity that enables the transmembrane transfer of a sodium ion by a channel that opens in response to a change in pH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12822", "l": "2-deoxy-D-ribose 5-phosphate => acetaldehyde + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296043", "l": "Activation of HCN channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69040", "l": "(2S)-2-nitrosobutanedioate + H(+) + NADPH + O2 = 2-nitrobutanedioate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27526", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate", "d": [], "t": []}, {"i": "EC:3.1.7.6", "l": "\"farnesyl diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17269", "l": "macrocin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + tylosin", "d": [], "t": []}, {"i": "EC:2.1.1.101", "l": "\"macrocin O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197963", "l": "DHFR2 reduces FOLA to DHF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848338", "l": "PNPLA4 hydrolyzes TAG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77612", "l": "Formation of dsRNA structure by looping  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69405", "l": "uracil(in) => uracil(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37771", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30077", "l": "cytosine + D-ribose 5-phosphate => CMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64425", "l": "H(+)(out) + L-leucyl-L-proline(out) => H(+)(in) + L-leucyl-L-proline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047505", "l": "(-)-menthol monooxygenase activity", "d": ["Catalysis of the reaction: (-)-menthol + H+ + NADPH + O2 = 1,4-menthane-3,8-diol + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28582", "l": "ATP + dUDP = ADP + dUTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607720", "l": "p100:RELB binds active NIK:p-IKKA dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112690", "l": "PTPN11 binds CBL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9861660", "l": "ME1 tetramer decarboxylates OA to PYR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36280", "l": "H(+) + NADH + O2 + theophylline => 3-methylxanthine + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77595", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103058", "l": "kaempferol 3-glucoside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-L-rhamnose = kaempferol-3-glucoside-7-rhamnoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047304", "l": "2-aminoethylphosphonate-pyruvate transaminase activity", "d": ["Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088210", "l": "Cytosolic glycoconjugates translocate to the lysosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65781", "l": "2 H(+) + metoxuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53124", "l": "all-trans-lycopene = delta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73589", "l": "CTP(in) + UMP(out) => CTP(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139842", "l": "Binding of Syk tyrosine kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65893", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate => H2O + xanthurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76629", "l": "H(+) + hydrogencarbonate + NADH + propanoyl-CoA => (S)-2-methyl-3-oxopropanoate + CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77576", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecylglycerol => 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11795", "l": "H(+) + NADH + O2 + propene <=> 1,2-epoxypropane + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43989", "l": "(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 => (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9843978", "l": "CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26384", "l": "4-hydroxybutanoate + NADP(+) <=> H(+) + NADPH + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55243", "l": "1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23110", "l": "D-arabinonate + H(+) => D-arabinono-1,4-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674018", "l": "BRAP binds RAS:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102650", "l": "cyclo-acetoacetyl-L-tryptophan synthetase activity", "d": ["Catalysis of the reaction: acetoacetyl-ACP + L-tryptophan + ATP = cyclo-acetoacetyl-L-tryptophan + AMP + diphosphoric acid + 2 H+ + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9825788", "l": "p-S207 KARS displaces HINT1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000995", "l": "RNA polymerase III general transcription initiation factor activity", "d": ["A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38864", "l": "phosphate + sucrose 6(F)-phosphate => alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186785", "l": "PDGF-AA clevage by Furin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47118", "l": "H2O + N-eicosanoylglycinate => eicosanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35352", "l": "NADP(+) + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12129", "l": "2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080046", "l": "quercetin 4'-O-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to the 4'-hydroxy group of a quercetin molecule."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36989", "l": "alpha-D-ribose 1,5-bisphosphate + cytosine => CMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72240", "l": "estrone 3-sulfate(out) + L-glutamate(in) => estrone 3-sulfate(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102715", "l": "gibberellin A17,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A17 + 2-oxoglutarate + O2 = gibberellin A28 + succinate + carbon dioxide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54718", "l": "H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250606", "l": "botD LC cleaves target cell VAMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15588", "l": "15-cis-phytoene + 4 A <=> 4 AH2 + all-trans-lycopene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62222", "l": "neopatulin => phyllostine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614614", "l": "Cysteine is degraded to serine and H2S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67073", "l": "a very long-chain fatty acyl-CoA + H2O => a very long-chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23434", "l": "(4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578965", "l": "TNRC6A binds AGO2:miRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791109", "l": "GADD45A binds PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46369", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629373", "l": "NEIL3 recognizes and binds to spiroiminodihydantoin in telomeric DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691131", "l": "CANDI binds CUL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2859050", "l": "Hydrolysis of C4b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59635", "l": "D-xylobiose + O2 <=> D-xylobiono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49557", "l": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] => H(+) + L-cysteinyl-[protein] + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38077", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72066", "l": "glycoursodeoxycholate(out) + 2 Na(+)(out) <=> glycoursodeoxycholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52751", "l": "alpha-isomaltosyl-(1->3)-isomaltose + H2O <=> 2 isomaltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804741", "l": "MDM2 forms homo- or heterodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15898", "l": "4-acetamidobutanoate + H2O => 4-aminobutanoate + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247847", "l": "WLS is endocytosed to the early endosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.23", "l": "\"rhamnogalacturonan endolyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2974737", "l": "NOTCH2 binds MDK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985153", "l": "OASL binds DDX58 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32063", "l": "8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21152", "l": "trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline", "d": [], "t": []}, {"i": "EC:5.1.1.8", "l": "\"4-hydroxyproline epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73362", "l": "ATP + beta-alanine + dopamine <=> AMP + beta-alanyl-dopamine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878237", "l": "RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23490", "l": "hydroquinone + NADP(+) => 1,4-benzoquinone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626914", "l": "α2-agonists bind ADRA2A,B,C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45011", "l": "H2O + N-(octadecanoyl)-sphinganine <=> octadecanoate + sphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29456", "l": "D-serine(in) => D-serine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77926", "l": "O2 + sym-homospermidine <=> H2O2 + N-(4-aminobutylpyrrolinium) ion + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9760402", "l": "ILF3 binds HOXC8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159773", "l": "Furin cleaves pro-protein S to protein S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654399", "l": "Activated FGFR2 binds FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72440", "l": "(E)-ferulate + ATP + H(+) => (E)-feruloyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008054", "l": "IL1F10 binds IL1RAPL1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004150", "l": "dihydroneopterin aldolase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5603467", "l": "Activated protein C is released from PROCR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018763", "l": "hydroxydechloroatrazine ethylaminohydrolase activity", "d": ["Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928656", "l": "gamma-secretase cleaves EPHB2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692755", "l": "CDK1 phosphorylates MAPK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53355", "l": "5,6-dihydrouridine(20b) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20b) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004665", "l": "prephenate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102516", "l": "delphinidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose = delphinidin 3,7-di O-beta-D-glucoside + ferulate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40205", "l": "14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62869", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + NADPH + O2 => H2O + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517705", "l": "p-S318,221-HuR binds mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32740", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429497", "l": "SLP-76 stimulates PLC gamma 2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9853499", "l": "DLD dimer dehydrogenates dihydrolipoyl (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40334", "l": "1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP <=> 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51848", "l": "8-methylmenaquinone-6 + succinate = 8-methylmenaquinol-6 + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40576", "l": "glutaryl-CoA + H2O => CoA + glutarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32549", "l": "(1R,5R)-sabinene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031844", "l": "type 4 neuropeptide Y receptor binding", "d": ["Binding to a type 4 neuropeptide Y receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12677", "l": "AH2 + Latia luciferin + 2 O2 = A + CO2 + formate + H(+) + H2O + hnu + oxidized Latia luciferin", "d": [], "t": []}, {"i": "EC:1.14.99.21", "l": "\"Latia-luciferin monooxygenase (demethylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614461", "l": "Tetramerization of procollagen VI (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008470", "l": "isovaleryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10779", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) <=> 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842655", "l": "IRS1 recruits GRB2 to active LTK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58872", "l": "24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19929", "l": "[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.12", "l": "\"cellulose synthase (UDP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49275", "l": "alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] <=> calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010328", "l": "auxin influx transmembrane transporter activity", "d": ["Enables the transfer of auxin, from one side of a membrane to the other, into a cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018760", "l": "thiocyanate hydrolase activity", "d": ["Catalysis of the reaction: H2O + 2 H+ + thiocyanate = carbonyl sulfide + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871265", "l": "YAP1 binds TEAD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205319", "l": "Interaction of APS and p-KIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72103", "l": "Formation of pre-mRNPs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199131", "l": "PVR binds CD226 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156699", "l": "Inactivation of Wee1 kinase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61707", "l": "ATP + holo-[peptidyl-carrier protein] + L-serine <=> AMP + diphosphate + L-seryl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954082", "l": "E2F6 binds the PRC1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421831", "l": "trans-Golgi Network Coat Assembly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32312", "l": "L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56104", "l": "2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2 = 4,4'-diaponeurosporenal + 2 A + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59968", "l": "L-threonyl-[protein] + octanoyl-CoA = CoA + O-octanoyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5631941", "l": "SESN1,2,3 bind AMPK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54817", "l": "L-glutaminyl-[protein] + L-lysyl-[protein] => [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56643", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23879", "l": "protoaphin aglucone <=> H2O + xanthoaphin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76456", "l": "O-atom dealkylation of dextromethorphan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9834945", "l": "PINK1 phosphorylates Ub on MOM proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785438", "l": "NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-936563", "l": "ISGylation of DDX58 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9681294", "l": "IL6R binds IL6R inhibitors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33275", "l": "a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.116", "l": "\"sn-1-specific diacylglycerol lipase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10548", "l": "L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O", "d": [], "t": []}, {"i": "EC:1.13.12.1", "l": "\"arginine 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008411", "l": "4-hydroxybutyrate CoA-transferase activity", "d": ["Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51102", "l": "16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000401", "l": "open form four-way junction DNA binding", "d": ["Binding to a DNA segment containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39354", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA <=> (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61636", "l": "ATP + CoA + isophthalate = AMP + diphosphate + isophthalyl-CoA", "d": [], "t": []}, {"i": "EC:6.2.1.58", "l": "\"isophthalate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854222", "l": "TBC1D3 associates with RAB5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78906", "l": "a medium-chain fatty acyl-CoA + acetyl-CoA <=> a medium-chain 3-oxoacyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050440", "l": "2-methylcitrate synthase activity", "d": ["Catalysis of the reaction: H2O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9727607", "l": "MME:Zn2+ binds sacubitrilat (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389972", "l": "alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102850", "l": "1-18:1-2-16:0-phosphatidylglycerol omega-6 desaturase activity", "d": ["Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor = 1-18:2-2-16:0-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63724", "l": "candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D-glucuronoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2247513", "l": "STAB1:ligand is endocytosed (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24061", "l": "N-hydroxy-L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16285", "l": "D-octopine + H2O + NAD(+) = H(+) + L-arginine + NADH + pyruvate", "d": [], "t": []}, {"i": "EC:1.5.1.11", "l": "\"D-octopine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22335", "l": "(3R)-citramalate <=> 2-methylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56560", "l": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32611", "l": "(6E)-8-hydroxygeranial + NADP(+) = (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76732", "l": "a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione => a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5225649", "l": "RBBP7 binds histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74091", "l": "ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016720", "l": "acyl-lipid Delta(12)-acetylenase", "d": ["Catalysis of the reaction: (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28223", "l": "3-dehydro-L-gulonate + ATP => 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54189", "l": "H2O + N-acetyl-L-phenylalanine => acetate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70170", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34551", "l": "ATP + cob(II)yrinate c monoamide + H2O + L-glutamine = ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18874", "l": "3-chloro-D-alanine + H2O => chloride + H(+) + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19858", "l": "a 16alpha-hydroxysteroid + NADP(+) => a 16-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65542", "l": "an N-acyl-sphingoid base + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose => a ganglioside GM3 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424254", "l": "LDLR transports extracellular CR:atREs to cytosol  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17390", "l": "D-arabinitol + NAD(+) => D-ribulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32065", "l": "8-oxo-dGMP + H(+) + phosphate => 8-oxo-dGDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33351", "l": "hexacosanoyl-CoA + sphinganine = CoA + H(+) + N-hexacosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67651", "l": "dATP + H2O <=> 2'-deoxyadenosine + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172666", "l": "RB1 binds condensin II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44405", "l": "3-demethylubiquinol-7 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64050", "l": "CoA + H(+) + N-(13Z-docosenoyl)-sphinganine => (13Z)-docosenoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172433", "l": "Collagen type XIX degradation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-555065", "l": "Formation of clathrin coated vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202534", "l": "Ubiquitination of NEMO by TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093332", "l": "p-EPHB phosphorylates SDC2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74031", "l": "L-alanine(in) + L-cysteine(out) = L-alanine(out) + L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40934", "l": "2-oxoglutarate + L-ornithine + O2 <=> (3S)-3-hydroxy-L-ornithine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481007", "l": "Exocytosis of platelet alpha granule contents (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9715356", "l": "brigatinib-resistant ALK mutants don't bind brigatinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008692", "l": "IL37(?-218) binds SMAD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42467", "l": "biphenyl-2,2',3-triol + O2 <=> 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72494", "l": "citrate(out) + maleate(in) <=> citrate(in) + maleate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30712", "l": "(S)-linalool => beta-myrcene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000103", "l": "CUBN:AMN binds CBLIF:RCbl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001876", "l": "lipoarabinomannan binding", "d": ["Binding to lipoarabinomannan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20896", "l": "ATP + hydrogencarbonate + urea = ADP + H(+) + phosphate + urea-1-carboxylate", "d": [], "t": []}, {"i": "EC:6.3.4.6", "l": "\"urea carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21795", "l": "NADP(+) + propan-2-ol <=> acetone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46755", "l": "7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61866", "l": "A + probetaenone I => AH2 + dehydroprobetaenone I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64570", "l": "ilicicolin H => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54695", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (13E)-labda-7,13-dien-15-yl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56591", "l": "a monosubstituted aliphatic (S)-hydroxynitrile <=> an aldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835358", "l": "p-TARBP2 binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610752", "l": "GLI3R translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62996", "l": "(8Z,11Z,14Z)-eicosatrienamide + H2O = (8Z,11Z,14Z)-eicosatrienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75079", "l": "Formation of AT-AC C complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202966", "l": "Caspase mediated cleavage of HIP-55 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60389", "l": "Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56774", "l": "2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O => 2 AH2 + all-trans-adonixanthin + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58606", "l": "FADH2-C4alpha-hydroperoxide + NAD(+) => FAD + 2 H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54367", "l": "2 acetaldehyde <=> acetoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52616", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP = 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004322", "l": "ferroxidase activity", "d": ["Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70481", "l": "TPI1 isomerizes GA3P to DHAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68530", "l": "beta-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76839", "l": "H2O + NAD(+) + propylamine = H(+) + NADH + NH4(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47021", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O => [DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73624", "l": "CTP(out) + GDP(in) => CTP(in) + GDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102460", "l": "kaempferol 3-gentiobioside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol-3-gentiobioside + UDP-L-rhamnose = H+ + kaempferol-3-O-gentiobioside-7-O-rhamnoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58380", "l": "NADP(+) + nonan-1-ol = H(+) + NADPH + nonanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382053", "l": "Translocation of PDGF from ER to Golgi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70501", "l": "PC carboxylates PYR to OA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38334", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78901", "l": "a long-chain 3-oxo-fatty acyl-CoA + CoA => a long-chain fatty acyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71164", "l": "HGD dioxygenates homogentisate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029451", "l": "Activation of RAC1 by VAV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35987", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22527", "l": "2 A + a carotenoid beta-end derivative <=> a carotenoid phi-end derivative + 2 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709366", "l": "CO translocates from cytosol to mitochondrial inner membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18693", "l": "a penicillin + H2O = 6-aminopenicillanate + a carboxylate", "d": [], "t": []}, {"i": "EC:3.5.1.11", "l": "\"penicillin amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68604", "l": "(2S)-3-sulfopropanediol = H(+) + hydroxyacetone + sulfite", "d": [], "t": []}, {"i": "EC:4.4.1.41", "l": "\"(2S)-3-sulfopropanediol sulfolyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016167", "l": "glial cell-derived neurotrophic factor receptor activity", "d": ["Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607740", "l": "PKC-delta phosphorylates CARD9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391372", "l": "GNRHR binds GNRH1,2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35822", "l": "5,6,7,8-tetrahydromethanopterin + NADP(+) <=> 7,8-dihydromethanopterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20239", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+) => (1S,4S)-5-oxo-1,2-campholide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031686", "l": "A1 adenosine receptor binding", "d": ["Binding to an A1 adenosine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62432", "l": "a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57733", "l": "A + all-trans-7,8-dihydroretinol => AH2 + all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.5.-", "l": "\"With a quinone or related compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34657", "l": "3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine => C30 botryococcene + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796070", "l": "NFE2L2 dependent CCL2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008765", "l": "UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity", "d": ["Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31460", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate => 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54688", "l": "alliin = 2-aminoprop-2-enoate + allylsulfenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211983", "l": "CYP2J2 oxidises ARA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2984226", "l": "PLK1 phosphorylates NEK9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18091", "l": "L-citrullyl-[protein] + NH4(+) => H2O + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0035256", "l": "G protein-coupled glutamate receptor binding", "d": ["Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75244", "l": "acetyl-CoA + N-terminal L-leucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-leucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77648", "l": "(2E,10E)-dode-2,10-dicenoyl-CoA + H(+) + oxaloacetate => [4-(deca-1,8-diyl)-2,5-dioxo-2,5-dihydro-3-furanyl]acetate + CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57116", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54249", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004089", "l": "carbonate dehydratase activity", "d": ["Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69964", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481007", "l": "Exocytosis of platelet alpha granule contents (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0015091", "l": "ferric iron transmembrane transporter activity", "d": ["Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44058", "l": "2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA => 2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67158", "l": "(9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+) => 1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76466", "l": "CYP4A11 12-hydroxylates DDCX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9824986", "l": "XPO1-dependent export of p-S69,S73 MITF-M (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31521", "l": "3-methyl-2-butenal + 4'-apo-beta-carotenal => O2 + torulene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72384", "l": "Na(+)(out) + urate(in) => Na(+)(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15774", "l": "ATP + dihydroxyacetone => ADP + dihydroxyacetone phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9824979", "l": "XPO1 binds p-S69,73 MITF-M (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75722", "l": "CoA-disulfide + H2O <=> 4'-phosphopantetheinyl-CoA disulfide + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45477", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187506", "l": "Translocation of p27 to the nucleoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15428", "l": "coproporphyrinogen III + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071532", "l": "ankyrin repeat binding", "d": ["Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28375", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66228", "l": "asc-C13-CoA + O2 = asc-DeltaC13-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9844587", "l": "GAL3ST1 transfers sulfate to GalCer,LacCer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4647593", "l": "EP400 binds CDKN1A promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549322", "l": "OCT1 transports organic cations out of hepatic cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140892", "l": "sodium,bicarbonate:chloride antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction chloride(in) + 2 hydrogencarbonate(out) + Na+(out) = chloride(out) + 2 hydrogencarbonate(in) + Na+(in)."], "t": []}, {"i": "TCDB:2.A.31.2.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54476", "l": "1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15418", "l": "L-arogenate + NADP(+) => CO2 + L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47154", "l": "2-oxoglutarate + 2 H(+) + NADH => 2,5-dioxopentanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70561", "l": "L-threonyl-[protein] + N-acetyl-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55946", "l": "chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+) => 2-chloroethanol + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46662", "l": "5beta-pregnan-3,20-dione + NADP(+) => H(+) + NADPH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850961", "l": "PREX2 binds PTEN and inhibits it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981610", "l": "Neuroglobin binds oxygen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943080", "l": "TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59869", "l": "4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine => 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008745", "l": "N-acetylmuramoyl-L-alanine amidase activity", "d": ["Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70753", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050223", "l": "protocatechuate decarboxylase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxybenzoate + H+ = catechol + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22777", "l": "2 H(+) + H2O2 + 2 Mn(2+) => 2 H2O + 2 Mn(3+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825837", "l": "MITF-M-dependent CDKN1A expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77398", "l": "hydrogen cyanide + propanal <=> (2S)-2-hydroxybutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26304", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) <=> (S)-allantoin + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65322", "l": "chrodrimanin A + CO2 + succinate => 2-oxoglutarate + chrodrimanin E + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685189", "l": "SARS-CoV-1 9b binds MAVS and PCBP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034929", "l": "1-hydroxypyrene 7,8-monooxygenase activity", "d": ["Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-7,8-oxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23863", "l": "acetyl-CoA + deacetylcephalosporin C <=> cephalosporin C + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23911", "l": "H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine <=> 2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24320", "l": "an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71098", "l": "2 Na(+)(out) + pregnenolone sulfate(out) <=> 2 Na(+)(in) + pregnenolone sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40126", "l": "an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36741", "l": "CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008010", "l": "structural constituent of chitin-based larval cuticle", "d": ["The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018491", "l": "2-oxobutyrate synthase activity", "d": ["Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626938", "l": "Beta-catenin binds SOX proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38702", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865605", "l": "BRWD1 binds SMARCA4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23583", "l": "prostaglandin H2 <=> prostaglandin I2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53049", "l": "2-hydroxyestrone + UDP-alpha-D-glucuronate => 2-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48796", "l": "O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203130", "l": "OLR1 binds to oxidized LDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38974", "l": "O2 + octadecanoyl-CoA <=> (2E)-octadecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63197", "l": "(10bR,4aS)-noroxomaritidine + H(+) + NADPH => (10bR,4aS)-oxomaritidine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44526", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoglycerol + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56451", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61089", "l": "(S)-eriodictyol + 2-oxoglutarate + O2 => (2R,3R)-dihydroquercetin + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75238", "l": "L-fucono-1,5-lactone <=> L-fucono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050457", "l": "decylcitrate synthase activity", "d": ["Catalysis of the reaction: H2O + lauroyl-CoA + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42780", "l": "adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.183", "l": "\"18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9770141", "l": "Formation of the Spliceosomal C* complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044589", "l": "pectin binding", "d": ["Binding to pectin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050442", "l": "3-propylmalate synthase activity", "d": ["Catalysis of the reaction: glyoxylate + H2O + pentanoyl-CoA = 3-propylmalate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71896", "l": "dGTP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41699", "l": "1-O-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78696", "l": "a ganglioside GA2 + UDP-alpha-D-galactose => a ganglioside GA1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004040", "l": "amidase activity", "d": ["Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56075", "l": "a 2-acylphloroglucinol + UDP-alpha-D-glucose <=> a 2-acylphloroglucinol 1-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9709179", "l": "DPP4 binds DPP4 inhibitors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420274", "l": "GIP receptor binds gastric inhibitory peptide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050099", "l": "methylglutamate dehydrogenase activity", "d": ["Catalysis of the reaction: N-methyl-L-glutamate + A + H2O = L-glutamate + AH(2) + formaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32742", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75978", "l": "(S)-stylopine + S-adenosyl-L-methionine <=> (S)-cis-N-methylstylopine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79156", "l": "(4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside(in) + ATP + H2O => (4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31561", "l": "H(+) + L-galactono-1,4-lactone + NADH => L-galactose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72178", "l": "5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) <=> 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14913", "l": "AMP + thymidine = adenosine + dTMP", "d": [], "t": []}, {"i": "EC:2.7.1.114", "l": "\"AMP--thymidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730858", "l": "Autophosphorylation of BTK/ITK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781018", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61546", "l": "ent-kaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21986", "l": "adenosine 3',5'-bisphosphate + choline sulfate + H(+) => 3'-phosphoadenylyl sulfate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75276", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (10R,11R)-epoxy-(9S)-hydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35990", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16439", "l": "a halide anion + an S-substituted glutathione + H(+) => glutathione + RX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24177", "l": "[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60743", "l": "(S)-(-)-citronellal + H2O + NADP(+) <=> (S)-(-)-citronellate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.138", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14415", "l": "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) => biphenyl-2,3-diol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709842", "l": "MAVS binds TOMM70 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53922", "l": "ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein] => ATP + L-threonyl-[Fas-activated protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209215", "l": "CI activates transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12293", "l": "ATP + L-serine + tRNA(Ser) => AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614460", "l": "Dimerization of procollagen type VI (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416929", "l": "PTGFR binds PGF2a (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22854", "l": "3-hydroxypyruvate + L-alanine => L-serine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709109", "l": "DHFR dimer binds DHFR inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71004", "l": "L-histidine(in) + L-phenylalanine(out) => L-histidine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55456", "l": "ferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + sugiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31388", "l": "(S)-2,3-epoxysqualene => alpha-amyrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0000702", "l": "oxidized base lesion DNA N-glycosylase activity", "d": ["Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56925", "l": "ATP + L-threonyl-[Goodpasture antigen-binding protein] => ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34878", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) <=> 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47317", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445084", "l": "Phosphorylation of L1 by SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13494", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) => (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018758", "l": "RHOH binds effectors at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47185", "l": "5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112156", "l": "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74716", "l": "Insulin binds the insulin receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218832", "l": "CDC42:GTP binds PAK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9705926", "l": "AR binds AR agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59100", "l": "diglucosyl-enterobactin + UDP-alpha-D-glucose = H(+) + triglucosyl-enterobactin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11930", "l": "H(+) + H2O + hydrazine => hydroxylamine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.13", "l": "\"sucrose synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.14", "l": "\"N-acetylglucosamine-6-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53009", "l": "(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate => di-trans,poly-cis-polyprenyl diphosphate + n diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78263", "l": "9-cis-retinol + a fatty acyl-CoA = 9-cis-retinyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432909", "l": "Interaction of Plectin with Integrin beta 4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78709", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginine => H2O + N-terminal L-arginyl-L-amino acid-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708557", "l": "FBXL17 binds BACH1:MAFK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45629", "l": "holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein] => holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24213", "l": "5-(2-hydroxyethyl)-4-methylthiazole + ATP => 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14775", "l": "corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine => 2 NADPH + palmatine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37010", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22778", "l": "2 H2O + 2 Mn(3+) => 2 H(+) + H2O2 + 2 Mn(2+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23142", "l": "D-ribose 5-phosphate + H(+) + nicotinamide => beta-nicotinamide D-ribonucleotide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54116", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + pseudolaratriene", "d": [], "t": []}, {"i": "EC:4.2.3.180", "l": "\"pseudolaratriene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21601", "l": "anthranilate + benzoyl-CoA => CoA + N-benzoylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58243", "l": "H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] <=> ADP-D-ribose + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16270", "l": "aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) => 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44414", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-10 => 3-demethylubiquinol-10 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52545", "l": "D-erythronate + NAD(+) => 2-dehydro-D-erythronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202726", "l": "F11R dimerises (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24279", "l": "acetate + diphosphate <=> acetyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31834", "l": "(2E,6E)-farnesyl diphosphate <=> delta-guaiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59873", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41329", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26278", "l": "Co-precorrin-4 + S-adenosyl-L-methionine => Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.7", "l": "\"deoxyribonuclease V\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050030", "l": "L-pipecolate dehydrogenase activity", "d": ["Catalysis of the reaction: L-pipecolate + acceptor = delta1-piperideine-6-carboxylate + reduced acceptor. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.68", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42770", "l": "a 2-oxocarboxylate + H(+) + NADPH => a (2S)-2-hydroxycarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69045", "l": "2-nitrobutanedioate => fumarate + H(+) + nitrite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669898", "l": "KIT mutants bind type I TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24343", "l": "(R,R)-butane-2,3-diol + NAD(+) <=> (R)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336454", "l": "MMGT1 transports Mg2+ from cytosol to Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24400", "l": "ATP + UMP = ADP + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40189", "l": "(3R)-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632738", "l": "DDIT4 binds 14-3-3 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42061", "l": "11-cis-retinol + NAD(+) => 11-cis-retinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30482", "l": "L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061898", "l": "all-trans retinoic acid 3,4-desaturase activity", "d": ["Catalysis of the reaction: all-trans-retinoic acid + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinoic acid + 2 H2O + 2 oxidized [adrenodoxin]."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35812", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol => (-)-medicarpin + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28648", "l": "acetophenone + 2 ATP + H2O + hydrogencarbonate => 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40123", "l": "an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205244", "l": "Recruitment of CBL to KIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.76", "l": "\"arylalkyl acylamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64913", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O => a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24483", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O <=> a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905054", "l": "calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29533", "l": "a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673346", "l": "Unknown kinase phosphorylates p-DVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13265", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine", "d": [], "t": []}, {"i": "EC:2.1.4.2", "l": "\"scyllo-inosamine-4-phosphate amidinotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30664", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole => hapalindole H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64900", "l": "H2O + UTP = H(+) + phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17389", "l": "D-arabinitol + NAD(+) = D-ribulose + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.250", "l": "\"D-arabinitol 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43546", "l": "ADP + gamma-L-glutamyltyramine + H(+) + phosphate => ATP + L-glutamate + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43802", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199935", "l": "MSK1 activates CREB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66585", "l": "3-oxocholestane + A + H2O => 25-hydroxy 3-oxocholestane + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75609", "l": "plasmodiophorol B => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46460", "l": "(22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54261", "l": "2-oxoglutarate + L-asparaginyl-[protein] + O2 => (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18607", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+) => 1-amino-1-deoxy-scyllo-inositol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16906", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9866217", "l": "HCCS inserts heme into cytochrome c (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731931", "l": "EDNRA binds selective ERAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12476", "l": "H2O + N-formyl-L-glutamate = formate + L-glutamate", "d": [], "t": []}, {"i": "EC:3.5.1.68", "l": "\"N-formylglutamate deformylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59895", "l": "L-2-amino-4-chloropent-4-enoate <=> chloride + H(+) + L-propargylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16680", "l": "fluoroacetaldehyde + H2O + NAD(+) <=> fluoroacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12987", "l": "GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53998", "l": "(14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15624", "l": "an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23648", "l": "dTDP-6-deoxy-beta-L-talose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8963734", "l": "IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76492", "l": "(E)-ferulate + H2O => acetate + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034043", "l": "5-hydroxymethyluracil DNA N-glycosylase activity", "d": ["Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73797", "l": "FAICAR => IMP + H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839039", "l": "Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1264832", "l": "JAK1 binds IL7R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43614", "l": "5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(341) in tmRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9824995", "l": "GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69218", "l": "(omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH => (omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874849", "l": "CREBRF binds CREB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23237", "l": "[protein]-L-glutamate 5-O-methyl ester + H2O => H(+) + L-glutamyl-[protein] + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835795", "l": "TFAP2A binds the PAX3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50414", "l": "H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu) => L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62083", "l": "D-glucose 6-sulfate + NADP(+) <=> 6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15796", "l": "(4Z,15Z)-bilirubin IXalpha + NADP(+) <=> biliverdin IXalpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65816", "l": "AH2 + ATP + 2 Co(II)-[methylamine-specific corrinoid protein] + H2O = A + ADP + 2 Co(I)-[methylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64496", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] = 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0005290", "l": "L-histidine transmembrane transporter activity", "d": ["Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141409", "l": "Mad1 binds kinetochore (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60421", "l": "H2O + triglucosyl-enterobactin => [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50356", "l": "4-hydroxy-6-methylpretetramide + NADPH + O2 = 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.233", "l": "\"4-hydroxy-6-methylpretetramide 12a-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005309", "l": "creatine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in)."], "t": []}, {"i": "REACT:R-HSA-200396", "l": "Creatine transport across the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25981", "l": "(5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71469", "l": "L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7) => H2O + substance P", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164840", "l": "ADP and Pi bind to ATPase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57539", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate <=> a 5'-end NTP-ribonucleotide-RNA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57155", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 <=> (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15823", "l": "2 AH2 + CO2 + hydrogen cyanide => 2 A + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61421", "l": "(S)-8-oxocitronellyl enol => cis-cis-nepetalactol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72675", "l": "3',5'-cyclic CMP + H2O = CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009046", "l": "zinc D-Ala-D-Ala carboxypeptidase activity", "d": ["Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938356", "l": "RMB14 binds RUNX2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65011", "l": "ATP + decanoate + H(+) <=> decanoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11707", "l": "2 H(+) + N-(carboxyaminomethyl)urea <=> CO2 + N-(aminomethyl)urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37518", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37255", "l": "A + D-asparagine + H2O = 2-oxosuccinamate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63403", "l": "Fe(II)-hydroxyheme i <=> Fe(II)-heme a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23860", "l": "acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.175", "l": "\"deacetylcephalosporin-C acetyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791016", "l": "SFTPB binds itself (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75482", "l": "S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) <=> S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047085", "l": "hydroxyphenylacetonitrile 2-monooxygenase activity", "d": ["Catalysis of the reaction: 4-hydroxyphenylacetonitrile + H+ + NADPH + O2 = 4-hydroxymandelonitrile + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41463", "l": "1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1,2-diacylglycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876230", "l": "InlB:MET dimer trans-autophophorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790025", "l": "Expression of BCL2, BCL2L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25307", "l": "7,8-dihydroneopterin + phosphate => 7,8-dihydroneopterin 3'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944230", "l": "Association of procollagen type XVIII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73718", "l": "UBF-1 Binds rDNA Promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70516", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose => 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39490", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA <=> (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35563", "l": "H2O + N-(9Z-hexadecenoyl) ethanolamine = (9Z)-hexadecenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840408", "l": "OMA1 cleaves DELE1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61763", "l": "rebaudioside B + UDP-alpha-D-glucose <=> rebaudioside A + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52313", "l": "NAD(+) + thromboxane B2 => 11-dehydro-thromboxane B2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75866", "l": "all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2537499", "l": "Gelatin degradation by MMP19 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60335", "l": "L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205319", "l": "Interaction of APS and p-KIT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40589", "l": "CoA + H(+) + octanedioate => H2O + octanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59372", "l": "1-hexadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + 10-hydroxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168849", "l": "tBID binds to inactive BAX protein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68248", "l": "L-tyrosine(in) + Na(+)(in) = L-tyrosine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11036", "l": "a quaternary ammonium(out) + ATP + H2O = a quaternary ammonium(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033533", "l": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000310", "l": "xanthine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59119", "l": "[protein]-dithiol + O2 <=> [protein]-disulfide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54949", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] => (2E,5Z)-dodecadienoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3159259", "l": "MMAA:MUT binds AdoCbl (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008804", "l": "carbamate kinase activity", "d": ["Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797974", "l": "LRRTMs bind NRXNs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68134", "l": "CoA + tetradecanoate phytyl ester => phytol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69713", "l": "beta-D-glucose + N-hexadecanoylsphinganine => beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66288", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46439", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649108", "l": "HTR3A pentamer binds 5HT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692315", "l": "OX40L binds OX40 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56102", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate => [small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66130", "l": "(2S)-2-aminobutanoate + 3-phenylpyruvate => 2-oxobutanoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78638", "l": "3-oxohexacosanoyl-CoA + H(+) + NADH <=> (3R)-hydroxyhexacosanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9604308", "l": "NICD4 traffics to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626549", "l": "IQGAPs bind CALM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52790", "l": "Mg(2+) + pheophytin a => chlorophyll a + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070335", "l": "aspartate binding", "d": ["Binding to aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004371", "l": "glycerone kinase activity", "d": ["Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603784", "l": "PEX19:class I PMP binds PEX3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987015", "l": "IL20 binds IL20RA:JAK1:IL20RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24497", "l": "4-O-deacetylvindoline + acetyl-CoA => CoA + vindoline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21847", "l": "L-glutamine + phenylacetyl-CoA <=> CoA + H(+) + N(2)-phenylacetyl-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840949", "l": "ARSA removes sulfate from SM3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060308", "l": "GTP cyclohydrolase I regulator activity", "d": ["Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78313", "l": "2 dADP => dAMP + dATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158849", "l": "Phenol can form a sulfate conjugate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404142", "l": "atROL binds RBP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76132", "l": "3',5'-cyclic GMP(out) + a dicarboxylate(in) => 3',5'-cyclic GMP(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53664", "l": "(2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + NH4(+) = H(+) + 2 H2O + pyridinestrone carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236970", "l": "Proteasomal clevage of exogenous antigen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24582", "l": "D-sorbitol + phosphate => D-sorbitol 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77551", "l": "(9Z)-octadecenoyl-CoA + 3-octadecanoyl-sn-glycerol = 1-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32665", "l": "(3R)-5-guanidino-3-methyl-2-oxopentanoate + H(+) + S-adenosyl-L-homocysteine => 5-guanidino-2-oxopentanoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56744", "l": "2-oxoglutarate + L-arginyl-[protein] + O2 = (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.73", "l": "\"[protein]-arginine 3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46149", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.265986832370587", "identifiers": [{"i": "GO:0005217", "l": "intracellularly ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018814", "l": "RHOT1 hydrolyzes GTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67586", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62434", "l": "a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine => a uridine in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66191", "l": "3',5'-cyclic GMP(in) + ATP + H2O <=> 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67732", "l": "uridylyl-uridylyl-ribonucleotide-RNA = a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13694", "l": "(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693536", "l": "ATM phosphorylates MDC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18623", "l": "a (2R,3R)-dihydroflavonol + CO2 + succinate => 2-oxoglutarate + a (2S)-flavan-4-one + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39730", "l": "a sphingomyelin(in) <=> a sphingomyelin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46487", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49420", "l": "ATP + valienone = ADP + H(+) + valienone 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36611", "l": "(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 = (5R)-carbapenem-3-carboxylate + CO2 + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.3", "l": "\"(5R)-carbapenem-3-carboxylate synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801109", "l": "CHM binds RGGT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75536", "l": "FMNH2 + N-acetyl-S-methyl-L-cysteine + O2 => (R)-N-acetyl-S-methyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43735", "l": "a triacyl-sn-glycerol + H2O <=> a 1,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29841", "l": "2-dehydro-L-idonate + H(+) + NADPH => L-idonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977371", "l": "Factor I inactivates Factor H-boundC3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48172", "l": "a ganglioside GM2 + H2O = a ganglioside GA2 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75242", "l": "acetyl-CoA + N-terminal L-methionyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40312", "l": "hexanoyl-CoA + O2 => (2E)-hexenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202960", "l": "Caspase mediated cleavage of C-IAP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65462", "l": "CoA + hexyl acetate => acetyl-CoA + hexan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.2.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390930", "l": "5-HT2 receptor can bind serotonin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49207", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,24R-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811412", "l": "Active ARF recruits coatomer to the Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399711", "l": "Activation of Ca impermeable AMPA receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830848", "l": "L protein acts as a cap N7 methyltransferase to modify RSV mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65692", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine = a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71952", "l": "3 Na(+)(out) + sulfate(out) => 3 Na(+)(in) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45643", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167097", "l": "HIV Promoter Opening: First Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034572", "l": "monodemethylisoproturon dimethylaminedehydrogenase activity", "d": ["Catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018766", "l": "RHOU binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.-", "l": "\"Enzymes altering nucleic acid conformation\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.369", "l": "\"enterobactin C-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061690", "l": "lipoamidase activity", "d": ["Catalysis of the reaction: H2O + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] = (R)-lipoate + L-lysyl-[lipoyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18847", "l": "2-hydroxy-3-oxopropanoate + H(+) + NADH => (R)-glycerate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61167", "l": "kaempferol + UDP-beta-L-rhamnose <=> H(+) + kaempferol 3-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033834", "l": "kaempferol 3-O-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683583", "l": "ATG10:ATG12:ATG7 dimer dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661188", "l": "Defective SLCO2A1 does not transport PGT substrates from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67898", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine => a 3'-end uridylyl-adenosine-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68911", "l": "ATP + H(+) + NADPH + picolinate <=> AMP + diphosphate + NADP(+) + picolinal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784959", "l": "BPHL hydrolyses VACV to ACV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43915", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734540", "l": "ACLY tetramer binds ETC-1002-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950362", "l": "EBI3:CANX binds IL12A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14463", "l": "(25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP => (25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68337", "l": "(R)-4'-phosphopantetheine sulfonate + H2O => (R)-pantetheine sulfonate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.2", "l": "\"chymotrypsin C\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22060", "l": "(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:2.8.1.6", "l": "\"biotin synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67544", "l": "(9Z)-tetradecenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75134", "l": "neomorphinone <=> morphinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611852", "l": "ADRB3 bind ADR,NAd (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52614", "l": "3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein] => 3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52836", "l": "H(+) + indole + NADH + O2 = H2O + indoxyl + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664850", "l": "ATM binds PEX5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28542", "l": "fluoroacetyl-CoA + H2O = CoA + fluoroacetate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.29", "l": "\"fluoroacetyl-CoA thioesterase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607722", "l": "Active NIK phosphorylates IKKA dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835165", "l": "Formation of hRSV A matrix lattice (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75555", "l": "(-)-cyatha-3,12-diene + O2 + reduced [NADPH--hemoprotein reductase] = erinacol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167047", "l": "pro-beta-NGF dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757688", "l": "SERPINA6 binds PREDN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59966", "l": "CoA + O-octanoyl-L-seryl-[protein] => L-seryl-[protein] + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64048", "l": "(13Z)-docosenoyl-CoA + sphinganine = CoA + H(+) + N-(13Z-docosenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17364", "l": "3-oxo-3-ureidopropanoate + H2O <=> H(+) + malonate + urea", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002134", "l": "UTP binding", "d": ["Binding to UTP, uridine 5'-triphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76502", "l": "N-acetyl-D-glutamate <=> N-acetyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983078", "l": "p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15304", "l": "D-apiitol + NAD(+) <=> aldehydo-D-apiose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986294", "l": "RUNX2 binds GLI2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3341294", "l": "Superoxide reduces cytochrome c (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46706", "l": "2-hydroxybenzoyl-5'-AMP + diphosphate => ATP + H(+) + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28245", "l": "O2 + pratensein + reduced [NADPH--hemoprotein reductase] <=> 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50852", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64384", "l": "H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine = alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4411373", "l": "NLK translocates to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13748", "l": "ascopyrone M <=> microthecin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59732", "l": "biotinyl-5'-AMP + L-lysyl-[protein] = AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52505", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] => (9R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15737", "l": "cyclopentanone + H(+) + NADPH + O2 = 5-valerolactone + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.16", "l": "\"cyclopentanone monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38915", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67861", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] => 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13055", "l": "3-phenylpyruvate + L-alanine => L-phenylalanine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20492", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) <=> 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45176", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010290", "l": "chlorophyll catabolite transmembrane transporter activity", "d": ["Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879925", "l": "SHC1 bound to the common beta chain becomes tyrosine phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446391", "l": "Formation of the PINCH-ILK-parvin complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201515", "l": "Active ALK recruits PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75232", "l": "H2O + L-galactono-1,4-lactone => H(+) + L-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22008", "l": "L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine", "d": [], "t": []}, {"i": "EC:2.3.1.46", "l": "\"homoserine O-succinyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950456", "l": "IL12B dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13937", "l": "4-sulfobenzoate + NADH + O2 = 3,4-dihydroxybenzoate + NAD(+) + sulfite", "d": [], "t": []}, {"i": "EC:1.14.12.8", "l": "\"4-sulfobenzoate 3,4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67961", "l": "4-amino-L-phenylalanine + S-adenosyl-L-methionine => 4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68375", "l": "L-asparagine + pyruvate <=> 2-oxosuccinamate + L-alanine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839094", "l": "Activated FGFR1 mutants and fusions bind PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928645", "l": "EPHB:NMDAR binds TIAM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72663", "l": "De novo formation of eIF2:GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33968", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O => 3-maleylpyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635843", "l": "GLI translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72141", "l": "estrone 3-sulfate(out) + H(+)(in) => estrone 3-sulfate(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031868", "l": "prostaglandin F2-alpha receptor binding", "d": ["Binding to a prostaglandin F2-alpha receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814831", "l": "TBC1D20 binds RAB1:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013004", "l": "RHOA binds effectors at the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61353", "l": "ATP + H2O + riboflavin(in) => ADP + H(+) + phosphate + riboflavin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201630", "l": "Caspase-mediated cleavage of Acinus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725338", "l": "NPM1-ALK-dependent BCL2A1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106614", "l": "Duplex miRNA is loaded into Argonaute (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936563", "l": "ISGylation of DDX58 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014296", "l": "RAC2 GEFs activate RAC2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220614", "l": "Spontaneous dimerization of ligand-responsive EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44695", "l": "a fatty acyl-CoA + hexadecasphinganine <=> CoA + H(+) + N-acylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58284", "l": "5,6-dihydrothymine + NADP(+) = H(+) + NADPH + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69635", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419645", "l": "Dimerization of LIMK1 by Hsp90 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53121", "l": "(3beta,5alpha,17beta)-3-hydroxyandrostan-17-yl sulfate + NADP(+) => 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73296", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine => 7,8-dihydroxy-4'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41525", "l": "5 H(+) + 5 malonyl-CoA => 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30799", "l": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851919", "l": "Activated MET binds GAB1 and GRB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168895", "l": "RNP association (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67737", "l": "N-acetyl-alpha-neuraminate => aceneuramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140111", "l": "[choline trimethylamine-lyase]-activating enzyme activity", "d": ["Catalyzes the activation of choline trimethylamine-lyase by generation of an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012074", "l": "FGFR3c P250R mutant binds to ligand with enhanced affinity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19370", "l": "L-histidyl-[protein] + S-adenosyl-L-methionine => H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111956", "l": "Calmodulin activates Cam-PDE 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77332", "l": "glyoxylate + L-ornithine => 5-amino-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011595", "l": "GSTZ1 dimer dehalogenates DCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34272", "l": "2-nitroimidazole + H2O => 1,3-dihydro-2H-imidazol-2-one + H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161193", "l": "abacavir + AMP => abacavir monophosphate + adenosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.23", "l": "\"sugar-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39786", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018814", "l": "RHOT1 hydrolyzes GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33453", "l": "AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] => A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444691", "l": "Prokineticin receptors bind prokineticin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683656", "l": "mRNA4 is translated to protein E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13337", "l": "D-glucurono-6,2-lactone + H2O = D-glucuronate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.19", "l": "\"uronolactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62234", "l": "a thymidine dimer in DNA => a thymidine(6-4)thymidine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903924", "l": "estradiol binding", "d": ["Binding to estradiol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9016861", "l": "PTCRA gene expression is stimulated by NOTCH3 and inhibited by IK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37963", "l": "galactitol + NAD(+) = D-galactose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0051020", "l": "GTPase binding", "d": ["Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727284", "l": "9b forms a homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654159", "l": "Activated FGFR2 binds PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853444", "l": "AURKA phosphorylates PHLDA1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202604", "l": "Formation of a heteromeric BMP receptor complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41083", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951644", "l": "Release of mature NEDD8 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52350", "l": "(24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36678", "l": "octacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(octacosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140931", "l": "neutral L-amino acid:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) + Cl-(out) = neutral L-amino acid(in) + Na+(in)+ Cl-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47518", "l": "isochenodeoxycholate + NAD(+) => 3-oxochenodeoxycholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21273", "l": "ATP + glutathione + spermidine => ADP + glutathionylspermidine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668417", "l": "cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49595", "l": "2-hydroxyisobutanoyl-CoA <=> (3S)-3-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21512", "l": "3,6-anhydro-L-galactonate = 2-dehydro-3-deoxy-L-galactonate", "d": [], "t": []}, {"i": "EC:5.5.1.25", "l": "\"3,6-anhydro-L-galactonate cycloisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003942", "l": "N-acetyl-gamma-glutamyl-phosphate reductase activity", "d": ["Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11329", "l": "dimethylallyl diphosphate + isopentenyl diphosphate => diphosphate + neryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41202", "l": "1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674093", "l": "PDGFRs bind type I TKI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52768", "l": "2-(glutathion-S-yl)-2-(1H-indol-3-yl)acetonitrile + H2O = 2-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetonitrile + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66759", "l": "ATP + domoate(in) + H2O <=> ADP + domoate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408509", "l": "Sec-tRNA(Sec) binds to EEFSEC:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38992", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21924", "l": "3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35735", "l": "a (2R)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9704297", "l": "CHRM2 binds CHRM2 antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14273", "l": "A + H2O + spermidine = 4-aminobutanal + AH2 + propane-1,3-diamine", "d": [], "t": []}, {"i": "EC:1.5.99.6", "l": "\"spermidine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168886", "l": "Hemopexin binds Hemes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-918232", "l": "Recruitment of IRF3,IRF7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25248", "l": "(R)-S-lactoylglutathione + H2O <=> (R)-lactate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193655", "l": "Myelin components can interact with p75NTR:NgR:LINGO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40216", "l": "FADH2 + O2 => FAD + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047569", "l": "3-oxoadipate CoA-transferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220610", "l": "Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685607", "l": "Sialic acid binds SIGLEC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683679", "l": "Ubiquination of protein E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47108", "l": "cholate + taurine = H2O + taurocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57467", "l": "(E)-caffeate + UDP-alpha-D-glucose <=> 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042960", "l": "antimonite secondary active transmembrane transporter activity", "d": ["Enables the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60145", "l": "ATP + L-glutamate + L-glutamyl-[protein] => ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58071", "l": "(E)-isoeugenol + O2 <=> acetaldehyde + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17239", "l": "diphosphate + FAD => ATP + FMN + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.77", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21295", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46949", "l": "GTP + S-adenosyl-L-methionine => N(7)-methyl-GTP + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391941", "l": "BLT receptors can bind LTB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33848", "l": "H2O + N-tetracosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9702849", "l": "CALCR binds gepants (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17528", "l": "biuret + H2O <=> NH4(+) + urea-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38457", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660662", "l": "ASC binds Caspase-8 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202127", "l": "eNOS synthesizes NO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332356", "l": "CAMK2 binds MAP3K7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40287", "l": "ATP + CoA + decanedioate = AMP + decanedioyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16578", "l": "ADP + ATP + H(+) => P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33877", "l": "(9Z)-octadecenoate + cholesterol + H(+) => cholesteryl (9Z-octadecenoate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103043", "l": "5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity", "d": ["Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O = H+ + alpha-D-ribose 1,5-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58692", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV = FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30074", "l": "acetyl-CoA + butanoate <=> acetate + butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38759", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445079", "l": "Phosphorylation of L1 by ERK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49492", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.153", "l": "\"sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30513", "l": "2-demethylmenaquinol-8 + NADP(+) => 2-demethylmenaquinone-8 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433967", "l": "Dimerized Phospho-IRF3 is Transported To The Nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78995", "l": "a 3-carboxymethyl-3-hydroxyacyl-[ACP] = a 4-carboxy-3-alkylbut-(2E)-enoyl-[ACP] + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.181", "l": "\"3-carboxymethyl-3-hydroxy-acyl-[ACP] dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47316", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15843", "l": "6-phospho-D-glucono-1,5-lactone + H(+) + NADPH => D-glucose 6-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17852", "l": "(3R)-3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55637", "l": "ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O => AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21888", "l": "(1S,2S)-OPC-8 + NADP(+) = (9S,13S,15Z)-12-oxophyto-10-15-dienoate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.42", "l": "\"12-oxophytodienoate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48613", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33038", "l": "2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034779", "l": "4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + H2O = 3-isopropenylpimelyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202722", "l": "CD48 binds CD244 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371527", "l": "HSF1 trimer translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803858", "l": "TP53 binds the SFN gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043779", "l": "cobalt-precorrin-5A acetaldehyde-lyase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210426", "l": "Glutamate synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169683", "l": "IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416530", "l": "FFAR1:FFAR1 ligands activate Gq (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052871", "l": "alpha-tocopherol omega-hydroxylase activity", "d": ["Catalysis of the reaction: (+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-alpha-tocopherol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20990", "l": "AMP + 2 H(+) + 2 phosphate => ATP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9794475", "l": "Cipro:ALB dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49179", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine <=> 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61747", "l": "steviolbioside + UDP-alpha-D-glucose <=> stevioside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71849", "l": "LDH tetramer reduces PYR to LACT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21357", "l": "L-arabinitol + NAD(+) => H(+) + L-ribulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50728", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime = 4-hydroxyphenylacetonitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75979", "l": "argipressin(out) = argipressin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749647", "l": "CES2 hydrolyzes ASA- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10242", "l": "a (2E)-enoyl-[ACP] + H(+) + NADH => a 2,3-saturated acyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49294", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein] => D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67011", "l": "a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0097644", "l": "calcitonin family binding", "d": ["Binding to a member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs))."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54884", "l": "L-arginyl-[protein] + NADP(+) = H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016509", "l": "long-chain-3-hydroxyacyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD+ = a long-chain 3-oxo-fatty acyl-CoA + H+ + NADH. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465924", "l": "OPN1LW binds 11cRAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15697", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043956", "l": "3-hydroxypropionyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: 3-hydroxypropionyl-CoA = acryloyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32488", "l": "CDP-choline + H2O => CMP + 2 H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13279", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate => [L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75315", "l": "chloride(out) + D-serine(out) + 2 Na(+)(out) = chloride(in) + D-serine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68694", "l": "3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77610", "l": "2 3-hexadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) <=> 3-hexadecanoyl-sn-glycero-1-phospho-(3'-hexadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25301", "l": "acetaldehyde + H2O + NADP(+) <=> acetate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28423", "l": "(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202245", "l": "Phosphorylation of TBSMs in LAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381435", "l": "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3364014", "l": "Recruitment of SET1 methyltransferase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11070", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose => (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5195402", "l": "CDK1 phosphorylates LPIN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106291", "l": "superoxide-generating NADH oxidase activity", "d": ["Catalysis of the reaction: NADH + 2 O2 = H+ + NAD+ + 2 superoxide."], "t": []}, {"i": "RHEA:63184", "l": "NADH + 2 O2 = H(+) + NAD(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692376", "l": "BCL2 binds BCL2 antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72590", "l": "(E)-sinapate + ATP + CoA <=> (E)-sinapoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048307", "l": "ferredoxin-nitrite reductase activity", "d": ["Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = nitrite + 6 reduced ferredoxin + 7 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26212", "l": "L-allo-threonine <=> acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31519", "l": "O2 + torulene = 3-methyl-2-butenal + 4'-apo-beta-carotenal", "d": [], "t": []}, {"i": "EC:1.13.11.59", "l": "\"torulene dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14701", "l": "2 CoA + NAD(+) = CoA-disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43304", "l": "3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer = 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167427", "l": "Opioid dissociates from MOR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56258", "l": "H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63898", "l": "isoaspulvinone E => aspulvinone E + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56173", "l": "FMN + O2 => 8-demethyl-8-formylriboflavin 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62214", "l": "gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29455", "l": "D-serine(in) = D-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27709", "l": "ATP + D-alanine + D-serine <=> ADP + D-alanyl-D-serine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192123", "l": "CYP27A1 27-hydroxylates CHOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421835", "l": "trans-Golgi Network Vesicle Scission (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035650", "l": "AP-1 adaptor complex binding", "d": ["Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21464", "l": "2 H(+) + H2O + thiocyanate = carbonyl sulfide + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.5.8", "l": "\"thiocyanate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57033", "l": "(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O => CO2 + formate + methylamine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654515", "l": "KAL1 binds HS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191299", "l": "Squalene is oxidized to its epoxide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65426", "l": "AMP(out) + NAD(+)(in) => AMP(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43103", "l": "S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) <=> 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25877", "l": "L-aspartate + O2 => H2O2 + iminosuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0015668", "l": "type III site-specific deoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48663", "l": "8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2168886", "l": "Hemopexin binds Hemes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53686", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9842835", "l": "KRAB-ZFP binds retroelement DNA in chromatin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70025", "l": "4-hydroxy-L-proline(out) + Na(+)(out) => 4-hydroxy-L-proline(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450488", "l": "BRF1 Complex recruits RNA degradation activities (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11915", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) <=> 15-oxoprostaglandin E2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78485", "l": "CMP-5'-(3-amino-3-carboxypropyl)phosphonate + diphosphate => 2-amino-4-phosphonobutanoate + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54957", "l": "ATP + CoA + OPC-6 => AMP + diphosphate + OPC-6-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77828", "l": "(2S)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O => 2-dehydro-D-glucose + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66788", "l": "N-methyl-L-dopa + O2 = (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33167", "l": "2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0090563", "l": "protein-phosphocysteine-sugar phosphotransferase activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17844", "l": "trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372425", "l": "fructose 2,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867613", "l": "PICALM binds R-SNAREs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18837", "l": "10-deacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C", "d": [], "t": []}, {"i": "EC:2.3.1.163", "l": "\"10-hydroxytaxane O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74270", "l": "n H(+)(out) + spermidine(in) <=> n H(+)(in) + spermidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15124", "l": "dithioerythritol + thiosulfate <=> cis-1,2-dithiane-4,5-diol + 2 H(+) + hydrogen sulfide + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20026", "l": "gibberellin A3 + UDP-alpha-D-glucose => gibberellin A3 O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693012", "l": "TNFSF15 binds TNFRSF25 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47073", "l": "1-eicosanoylglycerol + H2O => eicosanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016314", "l": "phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675910", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977301", "l": "Histidine is decarboxylated to histamine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376851", "l": "SLC25A11 exchanges 2-OG and MAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31190", "l": "(3S)-hydroxydecanoyl-CoA + NAD(+) <=> 3-oxodecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9853512", "l": "DLST transfers succinyl to CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030946", "l": "protein tyrosine phosphatase activity, metal-dependent", "d": ["Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701810", "l": "MECP2 binds the STAT5A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71559", "l": "5-N(alpha)-glycyl-dTMP in DNA + A + H2O = 5-aminomethyl-dUMP in DNA + AH2 + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036139", "l": "peptidyl-histidine dioxygenase activity", "d": ["Catalysis of the reaction: L-histidyl-[protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + succinate + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14658", "l": "aldehydo-D-ribose 5-phosphate => D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48600", "l": "[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65481", "l": "2-methylbutanoyl-CoA + hexan-1-ol => CoA + hexyl 2-methylbutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690873", "l": "ACO1 binds 4Fe-4S (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9842115", "l": "PSAP(195-273) dimer binds PE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187388", "l": "PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33313", "l": "2 AH2 + H(+) + H2O + N2 => 2 A + hydroxylamine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56199", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose <=> H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201521", "l": "ALK autophosphorylation  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28811", "l": "2,3-dioxo-L-gulonate(in) + Na(+)(in) = 2,3-dioxo-L-gulonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32870", "l": "myo-inositol(out) <=> myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13830", "l": "GDP-alpha-D-rhamnose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30382", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-beta-chamigrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30099", "l": "1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20746", "l": "15-oxoprostaglandin D2 + H(+) + NADPH => NADP(+) + prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52511", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70792", "l": "H(+)(in) + L-ornithine(out) => H(+)(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912368", "l": "SPO11 hydrolyzes DNA forming double-strand breaks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9660192", "l": "VDR agonists bind VDR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433451", "l": "JAK2 binds to p-KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58099", "l": "1-tetracosanoylglycerol + H2O <=> glycerol + H(+) + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392752", "l": "Phosphorylation of L1 by CK-II (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2509838", "l": "ITPA hydrolyses dITP to dIMP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13962", "l": "ATP + H2O + Mg(2+) + protoporphyrin IX => ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43023", "l": "L,L-cystathionine <=> 2-aminoprop-2-enoate + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27394", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951486", "l": "CD46 binds C4b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730902", "l": "Oligomerization of p-CARMA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0045290", "l": "D-arabinose 1-dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862700", "l": "CMKLR1 binds Resolvin E1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47217", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13271", "l": "an N-acylsphing-4-enine + D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008719", "l": "dihydroneopterin triphosphate 2'-epimerase activity", "d": ["Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25717", "l": "H(+) + H2O + N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1878002", "l": "XYLTs transfer Xyl to core protein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10303", "l": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate <=> (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34402", "l": "9-cis-beta-carotene + O2 <=> 9-cis-10'-apo-beta-carotenal + beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25935", "l": "4-methylquinoline + A + H2O <=> 4-methylquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42876", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63005", "l": "(11Z,14Z)-eicosadienamide + H2O => (11Z,14Z)-eicosadienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001790", "l": "polymeric immunoglobulin binding", "d": ["Binding to a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102205", "l": "cholesterol alpha-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cholesterol = UDP + cholesteryl beta-D-glucoside + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9838093", "l": "LONP1 binds mitochondrial matrix proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12582", "l": "H(+) + NADH + pyruvate + taurine => H2O + NAD(+) + tauropine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10042", "l": "AMP + phosphate => adenosine 3',5'-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70946", "l": "L-isoleucine(in) <=> L-isoleucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614614", "l": "Cysteine is degraded to serine and H2S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24423", "l": "H2O + N-terminal N-formyl-L-methionyl-[peptide] <=> formate + N-terminal L-methionyl-[peptide]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40431", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211904", "l": "CYP4F12 18-hydroxylates ARA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47626", "l": "1-pyrroline-2-carboxylate + H2O => cis-3-hydroxy-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686430", "l": "MUS81 binds EME1, EME2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450466", "l": "AUF1:mRNA complex is destroyed (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850961", "l": "PREX2 binds PTEN and inhibits it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627369", "l": "SEPT4 binds XIAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12717", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.140", "l": "\"inositol-tetrakisphosphate 5-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17223", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O => dTDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734713", "l": "ORC6 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043785", "l": "cinnamoyl-CoA:phenyllactate CoA-transferase activity", "d": ["Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9833635", "l": "p-PKR dimer localizes to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40710", "l": "(9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate <=> 1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691004", "l": "XPC binds RAD23 and CETN2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37994", "l": "delta-tocopherol + S-adenosyl-L-methionine <=> beta-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655404", "l": "SUMOylation of AURKA with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170979", "l": "(Frs2)C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70586", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35295", "l": "adenylyl-molybdopterin + H(+) + tungstate = AMP + H2O + W-molybdopterin cofactor", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65639", "l": "sphinga-(4E,8E)-dienine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21053", "l": "(S)-2-hydroxypropyl-coenzyme M + NAD(+) => 2-oxopropyl-coenzyme M + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174097", "l": "Association of Emi1 with Cdh1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35293", "l": "3-oxoisopentadecanoyl-CoA + CO2 + CoA => 11-methyldodecanoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047907", "l": "furylfuramide isomerase activity", "d": ["Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693111", "l": "RHOF auto-activates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11279", "l": "4 hydroquinone + O2 <=> 4 benzosemiquinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1299338", "l": "Activation of TRESK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56960", "l": "a ribonucleoside 5'-triphosphate + pyruvate = a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004408", "l": "holocytochrome-c synthase activity", "d": ["Catalysis of the reaction: holocytochrome c = apocytochrome c + heme."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64964", "l": "dUTP + 2 H2O = dUMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13158", "l": "(R)-glycerate + CO2 + NADP(+) => 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78072", "l": "a 2-acyl-sn-glycerol 3-phosphate + H2O => a 2-acylglycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65712", "l": "alpha-D-glucose 1-phosphate + GDP-beta-L-galactose = beta-L-galactose 1-phosphate + GDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45991", "l": "3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 <=> 3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62764", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72937", "l": "(S)-lactate(in) + 2 Na(+)(in) => (S)-lactate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36419", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28625", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol => (-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57818", "l": "2-deoxy-D-ribose 5-phosphate + guanine => dGMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42242", "l": "1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41938", "l": "a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73585", "l": "CTP(in) + UDP(out) => CTP(out) + UDP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17013", "l": "H(+) + phosphoenolpyruvate = 3-phosphonopyruvate", "d": [], "t": []}, {"i": "EC:5.4.2.9", "l": "\"phosphoenolpyruvate mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10897", "l": "2 H2O + limonin => 2 H(+) + limonoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35309", "l": "2,5-dihydroxybenzoate + H2O + NAD(+) => H(+) + NADH + O2 + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102007", "l": "acyl-L-homoserine-lactone lactonohydrolase activity", "d": ["Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone = H+ + an N-acyl-L-homoserine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662986", "l": "MT2A binds copper (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47064", "l": "4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57754", "l": "C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664567", "l": "ERBB2 KD mutants heterodimerize (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30229", "l": "dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+) => dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64373", "l": "beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O => alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140946", "l": "histone H3K4 dimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl4-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl4-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102639", "l": "paspalicine synthase activity", "d": ["Catalysis of the reaction: 13-desoxypaxilline + NADPH + O2 + H+ = paspalicine + NADP + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20843", "l": "H(+) + L-histidine <=> CO2 + histamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69482", "l": "beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26435", "l": "indole + L-serine => H2O + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19897", "l": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide", "d": [], "t": []}, {"i": "EC:1.14.13.39", "l": "\"nitric-oxide synthase (NADPH)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071860", "l": "proctolin receptor binding", "d": ["Binding to a proctolin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45472", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879782", "l": "Expression of AVP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12134", "l": "ADP + Cd(2+)(out) + H(+) + phosphate => ATP + Cd(2+)(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52488", "l": "O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13255", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+) => 1D-myo-inositol 1,3,4-trisphosphate + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49960", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 = 5,10-dihydrophenazine + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31347", "l": "(+)-abscisic acid D-glucopyranosyl ester + H2O = 2-cis-(+)-abscisate + beta-D-glucose + H(+)", "d": [], "t": []}, {"i": "EC:3.2.1.175", "l": "\"beta-D-glucopyranosyl abscisate beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19113", "l": "(8Z,11Z,14Z)-heptadecatrienal + A + H2O = (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15133", "l": "H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62473", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-nonadioyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48184", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16104", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate <=> n adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848150", "l": "STAT3 binds SOCS3 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72663", "l": "De novo formation of eIF2:GTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46144", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709179", "l": "DPP4 binds DPP4 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60863", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39514", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA <=> (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.114", "l": "\"polyprenyldihydroxybenzoate methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54412", "l": "a 3-oxo-5beta-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41976", "l": "a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1balpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60324", "l": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.359", "l": "\"[histone H3]-lysine(36) N-trimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22295", "l": "benzoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> biphenyl-3,5-diol + 4 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034543", "l": "5-aminosalicylate dioxygenase activity", "d": ["Catalysis of the reaction: 5-aminosalicylate + O2 = cis-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211968", "l": "CYP2W1 oxidises INDOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033701", "l": "dTDP-galactose 6-dehydrogenase activity", "d": ["Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710254", "l": "GSDME oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750226", "l": "NLRC5 binds IKBKB and CHUK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604732", "l": "Autocatalytic activation of proMMP13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11060", "l": "ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)", "d": [], "t": []}, {"i": "EC:6.1.1.5", "l": "\"isoleucine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15091", "l": "AH2 + pyruvate => (R)-lactate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050151", "l": "oleate hydratase activity", "d": ["Catalysis of the reaction: (R)-10-hydroxystearate = H2O + oleate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.29", "l": "\"sphingolipid 8-(E/Z)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33188", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004781", "l": "sulfate adenylyltransferase (ATP) activity", "d": ["Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74508", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B => (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77673", "l": "a globoside MSGG (d18:1(4E)) + CMP + H(+) => a globoside GalGb4Cer (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19815", "l": "2-oxosuccinamate + an L-alpha-amino acid => a 2-oxocarboxylate + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64944", "l": "dCTP + 2 H2O = dCMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34339", "l": "(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662620", "l": "MT3 binds cadmium (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817471", "l": "DPPA3 binds histone H3K9me2 in chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604731", "l": "Autocatalytic activation of MMP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72403", "l": "2-oxoglutarate(out) + urate(in) = 2-oxoglutarate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197690", "l": "Detachment of WASP/WAVE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61888", "l": "diosgenin + UDP-alpha-D-glucose = diosgenin 3-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11136", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.3.3", "l": "\"alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65331", "l": "A + chrodrimanin F <=> AH2 + chrodrimanin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54823", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61501", "l": "delphinidin + UDP-alpha-D-glucose => delphinidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39540", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH => (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68510", "l": "(Z)-beta-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353265", "l": "Interaction between two DNA-PK:DNA complexes at opposing ends of DNA DSB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71706", "l": "taurocholate(out) <=> taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693347", "l": "CRYM reduces P2C to PPCA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12898", "l": "2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] => (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817254", "l": "DUX4 binds HSATII pericentric repeat (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10368", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.59", "l": "\"dTDP-4-amino-4,6-dideoxygalactose transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32761", "l": "(3R)-3-methyl-D-ornithine => L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070281", "l": "pyridoxamine binding", "d": ["Binding to pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39434", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357432", "l": "AXL binds SRC-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700156", "l": "Active ALK dimer binds IRS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34453", "l": "dTDP-beta-L-rhamnose => dTDP-6-deoxy-beta-L-talose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12482", "l": "4,5-dioxopentanoate + L-alanine => 5-aminolevulinate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35687", "l": "NADP(+) + tetradecasphinganine = 3-oxotetradecasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40573", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15589", "l": "2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.72", "l": "\"D-4-hydroxyphenylglycine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449978", "l": "IL7 binds IL7R:JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10900", "l": "an aromatic L-alpha-amino acid + glyoxylate = an aromatic oxo-acid + glycine", "d": [], "t": []}, {"i": "EC:2.6.1.60", "l": "\"aromatic-amino-acid--glyoxylate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22729", "l": "H(+) + L-seryl-tRNA(Sec) + selenophosphate => L-selenocysteinyl-tRNA(Sec) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031746", "l": "type 1 cysteinyl leukotriene receptor binding", "d": ["Binding to a type 1 cysteinyl leukotriene receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462039", "l": "Pro-HNP1-4 are cleaved to biologically active defensin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58831", "l": "(9S,10R)-epoxy-octadecanoate + H2O <=> 9R,10R-dihydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12964", "l": "acetoacetate + butanoyl-CoA <=> acetoacetyl-CoA + butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56540", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol = 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956568", "l": "RUNX1 binds the core TAL1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102832", "l": "verbascose galactinol:ajugose galactosyltransferase activity", "d": ["Catalysis of the reaction: verbascose + alpha-D-galactosyl-(1->3)-1D-myo-inositol = ajugose + myo-inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012186", "l": "CHD1 translation is negatively regulated by miR-26A and B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4411373", "l": "NLK translocates to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732629", "l": "PPARG binds PPARG agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59264", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35394", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA <=> (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29228", "l": "H(+)(in) + indole(in) => H(+)(out) + indole(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52669", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate => [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66941", "l": "acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine => 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839080", "l": "Activated cytosolic FGFR1 fusions bind PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78735", "l": "(3S)-hydroxytetracosanoyl-CoA + NAD(+) = 3-oxotetracosanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374686", "l": "L1 interaction with Integrins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694433", "l": "MIA2 binds PREB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62715", "l": "betaenone C + H(+) + NADPH + O2 <=> H2O + NADP(+) + stemphyloxin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389862", "l": "Conversion of glyoxylate to oxalate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51835", "l": "ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33995", "l": "gamma-L-glutamyl-butirosin B = 5-oxo-L-proline + butirosin B", "d": [], "t": []}, {"i": "EC:4.3.2.6", "l": "\"gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35516", "l": "4'''-demalonylsalvianin + malonyl-CoA => CoA + salvianin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004999", "l": "vasoactive intestinal polypeptide receptor activity", "d": ["Combining with vasoactive intestinal polypeptide to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451311", "l": "Activation of Ca-permeable Kainate receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44615", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941411", "l": "OSCN- reacts with Cys residues (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40222", "l": "H2O + malonyl-CoA <=> CoA + H(+) + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69278", "l": "but-3-enenitrile + sulfate + sulfur => (Z)-N-(sulfonatooxy)prop-2-enimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106258", "l": "L-serine-phosphatidylcholine phosphatidyltransferase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline."], "t": []}, {"i": "RHEA:45088", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018607", "l": "1-indanone monooxygenase activity", "d": ["Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67195", "l": "ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out) <=> ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8934742", "l": "RUNX1 binds PRMT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41995", "l": "17beta-hydroxy-5alpha-androstan-3-one + NAD(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30598", "l": "4-hydroxyphenylacetate + FADH2 + O2 <=> 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74740", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine => 7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835454", "l": "DNAJC3 binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34772", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) => a 3-oxosteroid + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168883", "l": "Haptoglobin:Hemoglobin binds CD163 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33257", "l": "H(+) + menaquinol-7 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-7 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759147", "l": "NFE2L2 and MAFG bind the SQSTM1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47043", "l": "5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] <=> 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70948", "l": "L-tryptophan(in) => L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10887", "l": "(24R,24(1)R)-fucosterol epoxide <=> acetaldehyde + desmosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30761", "l": "NH4(+) + thymine => 5-methylcytosine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74370", "l": "substance P(out) <=> substance P(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18926", "l": "L-gulono-1,4-lactone + NADP(+) => D-glucurono-3,6-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51075", "l": "a phenol + an aryl sulfate <=> a phenol + an aryl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12362", "l": "13-(2-methylcrotonoyloxy)lupanine + CoA => (2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835009", "l": "PRKN binds p-S-Ub:MOM proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029445", "l": "An unknown GEF exchanges GTP for GDP on CDC42:GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033999", "l": "chondroitin B lyase activity", "d": ["Catalysis of the reaction: dermatan sulfate = n 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate. This reaction is the eliminative cleavage of dermatan sulfate containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucurosonyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAC-4S). Chondroitin sulfate B is also known as dermatan sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41166", "l": "1-O-hexadecyl-2-amino-sn-glycerol + ATP <=> 1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74298", "l": "n H(+)(out) + serotonin(in) <=> n H(+)(in) + serotonin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53088", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69889", "l": "Na(+)(in) + uridine(in) => Na(+)(out) + uridine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69844", "l": "a 5,6-dihydrouridine in RNA + NAD(+) => a uridine in RNA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213017", "l": "Auto-ubiquitination of TRAF3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610388", "l": "HCMV translocates from the endosome lumen to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52011", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA <=> 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70616", "l": "hexadecanoyl-[ACP] + L-lysyl-[protein] => H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936745", "l": "deacetylation of O-acetylserine and sulfhydrylation using CysK2 (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33179", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.11", "l": "\"phosphoinositide phospholipase C\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129357", "l": "Fibrillin C-terminal processing (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374298", "l": "Opioid receptors bind opioid peptides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180709", "l": "Association of multimerized Rev with beta-importin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2995334", "l": "COX15 transforms heme O to heme A (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730856", "l": "Autophosphorylation of PAK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72818", "l": "L-lysine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) <=> L-lysine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10203", "l": "butanoate + NAD(+) <=> (2E)-2-butenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69583", "l": "dGMP + inosine <=> 2'-deoxyguanosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55930", "l": "fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => fenbendazole + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78487", "l": "CMP-5'-(3-amino-3-carboxypropyl)phosphonate + H(+) = CMP-5'-(3-aminopropyl)phosphonate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975879", "l": "Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035180", "l": "Expression of EEPD1 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912727", "l": "CBL binds VAV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2317332", "l": "PIP3 recruits AKT to the membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35754", "l": "ATP + kanosamine <=> ADP + D-kanosamine 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453183", "l": "p-Y348-SYK dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9866253", "l": "apo-UQCRFS1 binds LYRM7 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16187", "l": "a carboxylate + 2 H(+) + NADH => an aldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15575", "l": "H(+) + melatonin + S-adenosyl-L-homocysteine => N-acetylserotonin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839363", "l": "TGFBR3 phosphorylation by TGFBR2 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730835", "l": "Autophosphorylation of PKC-theta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4341048", "l": "SUMOylation of RXRA with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55195", "l": "2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 <=> 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42556", "l": "uridine(2819) in 21S rRNA = pseudouridine(2819) in 21S rRNA", "d": [], "t": []}, {"i": "EC:5.4.99.43", "l": "\"21S rRNA pseudouridine(2819) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647660", "l": "GSDME (1-270) binds PIPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67526", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine => 4,8-dimethylnonanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204813", "l": "Interaction of Tie2 and Grb14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163743", "l": "Transcriptional activation of ACACA by ChREBP:MLX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63094", "l": "H2O + ilicicolin A epoxide + NADP(+) => H(+) + ilicicolin A + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60199", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(9)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49368", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) = 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044540", "l": "L-cystine L-cysteine-lyase (deaminating)", "d": ["Catalysis of the reaction: L-cystine + H2O = pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839114", "l": "BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76977", "l": "(9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018756", "l": "RHOH binds GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050118", "l": "N-acetyldiaminopimelate deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211301", "l": "PDX1-dependent synthesis of IAPP protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78106", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine <=> a 2-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701064", "l": "TRPV1 binds TRPV1 agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32026", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> avermitilol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047632", "l": "agmatine deiminase activity", "d": ["Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730886", "l": "Phosphorylation of SHC by SYK kinase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59147", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide <=> 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848436", "l": "PTK6 phosphorylates CDKN1B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58033", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18515", "l": "D-mannose + H2O2 => D-mannitol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41958", "l": "cytidine 2'-phosphate + H(+) => 2',3'-cyclophospho-CMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174551", "l": "Formation of alternative pathway C5 convertase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.71648590403835", "identifiers": [{"i": "GO:0061660", "l": "Atg12 ligase activity", "d": ["Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S = X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15215", "l": "CoA + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] => N(6)-[(R)-dihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75006", "l": "ATP + CoA + sulfoacetate <=> AMP + diphosphate + sulfoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378956", "l": "Luteinizing hormone is a heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59521", "l": "ATP + butanoyl-CoA + hydrogencarbonate => (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34855", "l": "2 H2O + iminodiacetonitrile = N-(cyanomethyl)glycine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876789", "l": "CARNMT1 methylates CARN to Anserine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59910", "l": "2 H(+) + hexanoate + NADPH => H2O + hexanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018634", "l": "alpha-pinene monooxygenase (NADH) activity", "d": ["Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434836", "l": "Syk/Lck phosphorylate LAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210767", "l": "HNF6-dependent synthesis of ONECUT3 protein during early pancreas specification (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76603", "l": "(12Z)-10-hydroxyoctadecenoate + H2O = 10,13-dihydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679775", "l": "COMT binds COMT Inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77436", "l": "a ganglioside GT1c + CMP-N-acetyl-beta-neuraminate => a ganglioside GQ1c + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754974", "l": "ADK phosphorylates RBV (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32531", "l": "4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = alpha-D-mannose 1-phosphate + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.281", "l": "\"4-O-beta-D-mannosyl-D-glucose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033405", "l": "UCU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UCU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983700", "l": "SYK binds the activated BCR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429101", "l": "HMIT co-transports myo-inositol with a proton (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56795", "l": "2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27658", "l": "2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030585", "l": "phosphoenolpyruvate carboxykinase (diphosphate) activity", "d": ["Catalysis of the reaction: diphosphate + oxaloacetate = CO2 + phosphate + phosphoenolpyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205321", "l": "Interaction of KIT and sSCF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65175", "l": "(3Z,5E)-dodecadienoyl-CoA + H2O <=> (3Z,5E)-dodecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64375", "l": "beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O <=> alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48439", "l": "H2O + pentanoate ester <=> an aliphatic alcohol + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20606", "l": "cytosine + H(+) + H2O => NH4(+) + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693108", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74258", "l": "H2O + L-homoseryl-tRNA(Ser) <=> H(+) + L-homoserine + tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27509", "l": "cocaine + H2O <=> benzoate + ecgonine methyl ester + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15593", "l": "amicoumacin A 2-phosphate + H2O = amicoumacin A + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.107", "l": "\"amicoumacin phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18115", "l": "a ribonucleoside 5'-triphosphate + ADP => a ribonucleoside 5'-diphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.-.-", "l": "\"Glycosylases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26185", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O => 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74128", "l": "peonidin + UDP-alpha-D-galactose => peonidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913456", "l": "Interleukin-5 receptor alpha subunit binds Interleukin-5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33442", "l": "glyoxal + H2O + O2 <=> glyoxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785594", "l": "FANCD2 binds FANCI (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036065", "l": "Defective ARSB does not hydrolyse DS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692437", "l": "ANG binds F-actin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14672", "l": "D-glyceraldehyde 3-phosphate + H2O + NADP(+) <=> (2R)-3-phosphoglycerate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.3", "l": "\"monoterpenyl-diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71614", "l": "(S)-malate(in) + malonate(out) <=> (S)-malate(out) + malonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66355", "l": "(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) <=> (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60807", "l": "2-oxoglutarate + gibberellin A19 + O2 <=> CO2 + gibberellin A17 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22306", "l": "5-dehydro-D-fructose + a ubiquinol => a ubiquinone + keto-D-fructose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19561", "l": "androst-4-ene-3,17-dione + H(+) + NADPH + O2 = H2O + NADP(+) + testololactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016630", "l": "protochlorophyllide reductase activity", "d": ["Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759158", "l": "SQSTM1 oligomerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51076", "l": "2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate = 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48626", "l": "(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate => (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32070", "l": "8-oxoguanine + H(+) + H2O <=> NH4(+) + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.10", "l": "\"ferric-chelate reductase [NAD(P)H]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9835328", "l": "NPM binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28526", "l": "(R)-carnitine + crotonobetainyl-CoA = (R)-carnitinyl-CoA + crotonobetaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38160", "l": "(2S,3S)-hydroxyarginine => (2S,3R)-capreomycidine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061697", "l": "protein-glutaryllysine deglutarylase activity", "d": ["Catalysis of the reaction: H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD+ = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:47664", "l": "H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37738", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41546", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine => 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-139941", "l": "Binding of IP3 to IP3 receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37566", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24448", "l": "enterobactin + UDP-alpha-D-glucose = monoglucosyl-enterobactin + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54647", "l": "trans-4-hydroxy-L-proline <=> (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5631885", "l": "PRDX1 overoxidizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78472", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55942", "l": "all-trans-3,4-didehydroretinal + H(+) + NADH => all-trans-3,4-didehydroretinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47749", "l": "a ubiquinone + H(+) + n Na(+)(in) + NADH => a ubiquinol + n Na(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603062", "l": "Complexed PIWIL2 binds  pre-piRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73598", "l": "CTP(out) + dUMP(in) <=> CTP(in) + dUMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22975", "l": "butanal + CoA + NADP(+) <=> butanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19178", "l": "L-lysine => (3S)-3,6-diaminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25292", "l": "acetaldehyde + H(+) + NADH => ethanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32952", "l": "sucrose => trehalulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38013", "l": "chlorophyllide a + H(+) + phytol => chlorophyll a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35594", "l": "H2 + n sulfur <=> H(+) + hydrogen sulfide + (n-1) sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607753", "l": "CARD9 oligomerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109639", "l": "Formation of the closed pre-initiation complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22524", "l": "2 A + a carotenoid beta-end derivative = a carotenoid phi-end derivative + 2 AH2", "d": [], "t": []}, {"i": "EC:1.3.99.39", "l": "\"carotenoid phi-ring synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14481", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.87", "l": "\"2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034075", "l": "arabidiol synthase activity", "d": ["Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76259", "l": "H(+)(in) + taurine(in) = H(+)(out) + taurine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9718020", "l": "PTGFR binds PTGFR agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.74", "l": "\"methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))-methyltransferase [NAD(P)H-oxidizing]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65515", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 <=> 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839102", "l": "BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28323", "l": "UDP-alpha-D-glucuronate + wogonin => UDP + wogonin 7-O-beta-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51733", "l": "glandicoline B + S-adenosyl-L-methionine => H(+) + meleagrin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32370", "l": "4 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone <=> 4 Fe(II)-[cytochrome c] + 5 H(+) + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984775", "l": "Kinesin-9 is a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58229", "l": "L-asparaginyl-[protein] + NAD(+) => H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20580", "l": "3-hydroxyaminophenol <=> aminohydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64989", "l": "CoA + H2O => (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32957", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32303", "l": "(2R)-homocitrate = (2R,3S)-homoisocitrate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69116", "l": "Formation of Okazaki fragments (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34361", "l": "a 2-acylglycerol + a carboxylate + H(+) => a 1,2-diacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655848", "l": "Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51213", "l": "(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) => 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74469", "l": "a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + sulfate => a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52825", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 => (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637798", "l": "Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57370", "l": "(6R)-NADPHX => H2O + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004483", "l": "mRNA (nucleoside-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199046", "l": "Ligands bind L-selectin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786854", "l": "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68339", "l": "(R)-4'-phosphopantetheine sulfonate + H2O <=> (R)-pantetheine sulfonate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33947", "l": "2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine = 2'-N-acetylparomamine + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.283", "l": "\"2-deoxystreptamine N-acetyl-D-glucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029471", "l": "Hydrolysis of PC to PA by PLD (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004666", "l": "prostaglandin-endoperoxide synthase activity", "d": ["Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34925", "l": "nitrate(out) => nitrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660819", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710101", "l": "CASP4, CASP5 cleave GSDMD (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132094", "l": "C8 binds to C5b:C6:C7 complement complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42507", "l": "2-oxoglutarate + N(6)-acetyl-L-lysine <=> 6-acetamido-2-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68323", "l": "1D-myo-inositol 2,4,5-triphosphate + H2O <=> 1D-myo-inositol 2,5-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863471", "l": "LDLR is bound by DAB2 and ARH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030791", "l": "arsenite methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76982", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28426", "l": "D-allulose 6-phosphate = keto-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21776", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.28", "l": "\"3alpha,7alpha-dihydroxy-5beta-cholestanate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015362", "l": "high-affinity sodium:dicarboxylate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}, {"i": "REACT:R-HSA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5260201", "l": "p-AKT2 phosphorylates C2CD5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76416", "l": "3',3'-cGAMP(out) + n H(+)(out) => 3',3'-cGAMP(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031624", "l": "ARC gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9839388", "l": "TGFBR3 translocation to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51932", "l": "2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite = 2 Fe(II)-[cytochrome c3] + thiosulfate", "d": [], "t": []}, {"i": "EC:1.8.2.5", "l": "\"thiosulfate reductase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683764", "l": "Spike trimer translocates to ERGIC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.45", "l": "\"aromatic aldoxime N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70335", "l": "2-carboxy-L-lyxonolactone + H2O = 2-carboxy-L-lyxonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647680", "l": "CASP1 cleaves GSDMD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20530", "l": "2-cis-(+)-abscisic aldehyde + H2O + O2 => 2-cis-(+)-abscisate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018517", "l": "phthalate 4,5-cis-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67908", "l": "a primary linear alkyl sulfate ester + H2O = a primary alcohol + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.21", "l": "\"linear primary-alkylsulfatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48143", "l": "2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465940", "l": "atRAL is reduced to atROL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25210", "l": "H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine => acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75428", "l": "eburicol + O2 + reduced [NADPH--hemoprotein reductase] => 32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853792", "l": "RET tyrosine phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782943", "l": "UV-DDB ubiquitinates XPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66694", "l": "dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein] => dTDP-beta-L-rhamnose + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12968", "l": "ATP + D-galacturonate <=> 1-phospho-alpha-D-galacturonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24035", "l": "sucrose <=> 6-O-alpha-D-glucopyranosyl-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32850", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33366", "l": "D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-mannitol 1-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110172", "l": "MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32544", "l": "(2E)-geranyl diphosphate + H2O => 1,8-cineole + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58073", "l": "a 4,5-didehydrojasmonate + H(+) + NADPH => a jasmonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75620", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate => ectocarpin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909729", "l": "Activation of JAK kinases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2201341", "l": "Endocytosis of TRAM (TICAM2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839072", "l": "HTRA2 degrades APP (Amyloid-beta precursor protein) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49002", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+) => aurachin C + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164834", "l": "Enzyme-bound ATP is released (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57180", "l": "L-lysyl-[protein] + methylglyoxal = N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805035", "l": "TP53 binds STK11 and NUAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40031", "l": "ent-copalyl diphosphate + H2O = diphosphate + ent-manool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22316", "l": "13-hydroxydocosanoate + UDP-alpha-D-glucose = 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.158", "l": "\"13-hydroxydocosanoate 13-beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033717", "l": "gluconate 2-dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004869", "l": "cysteine-type endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761834", "l": "NFE2L2 binds the TKT gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69398", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP] => a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49439", "l": "cholate + deoxycholoyl-CoA <=> choloyl-CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692749", "l": "CDC14A,B bind MAPK6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097005", "l": "adipokinetic hormone receptor binding", "d": ["Binding to an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9825782", "l": "p-S207 KARS1 dimer binds MITF-M:HINT1 dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45958", "l": "(9Z)-octadecenoyl-CoA(out) => (9Z)-octadecenoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445079", "l": "Phosphorylation of L1 by ERK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28630", "l": "O2 + reduced [NADPH--hemoprotein reductase] + solavetivol <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5669158", "l": "NF2 binds PAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17699", "l": "5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine => pyridine + thiamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374669", "l": "L1 binds NRP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17342", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) => 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71048", "l": "glycine(in) + L-phenylalanine(out) => glycine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60660", "l": "1,4-benzoquinone + H(+) + NADH = hydroquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031702", "l": "type 1 angiotensin receptor binding", "d": ["Binding to a type 1 angiotensin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9796617", "l": "MIB2 binds CFLAR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0140296", "l": "general transcription initiation factor binding", "d": ["Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15004", "l": "keto-L-sorbose + NADP(+) <=> 5-dehydro-D-fructose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57657", "l": "a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate => a ganglioside GT1balpha + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0052673", "l": "prenol kinase activity", "d": ["Catalysis of the reaction: prenol + nucleoside triphosphate = prenyl phosphate + nucleoside diphosphate activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23552", "l": "2-methylpropane-1,2-diol + NAD(+) = 2-hydroxy-2-methylpropanal + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.400", "l": "\"2-methyl-1,2-propanediol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706837", "l": "AR binds AR antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013143", "l": "RAC1 GEFs activate RAC1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49780", "l": "docosanoyl-CoA + glycine = CoA + H(+) + N-docosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36662", "l": "carbamoyl phosphate + descarbamoylnovobiocin <=> novobiocin + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2534365", "l": "Slo3 Potassium Transport (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65987", "l": "hnu + previtamin D3 <=> lumisterol 3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30273", "l": "2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O => 2 (3,4-dimethoxyphenyl)methanol + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876868", "l": "ECE1 cleaves EDN1(53-90) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48145", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine => ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54262", "l": "(3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53025", "l": "a plastoquinone + H2O + L-arginine => 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72373", "l": "dehydroepiandrosterone 3-sulfate(in) + succinate(out) => dehydroepiandrosterone 3-sulfate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68236", "l": "L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592240", "l": "Formation of NRF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.3", "l": "\"cystinyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606839", "l": "ARSC hydrolyzes steroid sulfates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48987", "l": "(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + glyoxylate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67414", "l": "carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009496", "l": "plastoquinol--plastocyanin reductase activity", "d": ["Catalysis of the reaction: 2 H+[side 1] + 2 oxidized plastocyanin + plastoquinol-1 = 2 H+[side 2] + 2 reduced plastocyanin + plastoquinone. This reaction involves the concomitant transfer of 2 H+ ions across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63687", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP <=> (4R,5S)-dethiobiotin + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052902", "l": "spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity", "d": ["Catalysis of the reaction: H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22388", "l": "acetyl-CoA + N(6)-hydroxy-L-lysine = CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": [], "t": []}, {"i": "EC:2.3.1.102", "l": "\"N(6)-hydroxylysine O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71959", "l": "3 Na(+)(out) + oxaloacetate(out) = 3 Na(+)(in) + oxaloacetate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78865", "l": "a short-chain (2E)-enoyl-CoA + H2O => a short-chain (3R)-hydroxy fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004834", "l": "tryptophan synthase activity", "d": ["Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59536", "l": "ATP + butanoyl-CoA + hydrogencarbonate = (2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45211", "l": "coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] <=> Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53227", "l": "16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358790", "l": "RNF41 ubiquitinates ERBB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29999", "l": "ATP + H2O + spermidine(out) = ADP + H(+) + phosphate + spermidine(in)", "d": [], "t": []}, {"i": "EC:7.6.2.11", "l": "\"ABC-type polyamine transporter\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60331", "l": "L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59425", "l": "benzylamine + H2O + O2 => benzaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66705", "l": "H2O + mycophenolyl-CoA => CoA + H(+) + mycophenolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72435", "l": "(E)-caffeoyl-AMP + CoA = (E)-caffeoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139909", "l": "Translocation of BMF to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20439", "l": "2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH => 5D-5-O-methyl-chiro-inositol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012835", "l": "GDIs block activation of RHOA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62089", "l": "D-glucosamine 6-phosphate + NADP(+) => 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53601", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202174", "l": "Activation of ZAP-70 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44020", "l": "H2O + NAD(+) + octadecanal = 2 H(+) + NADH + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50571", "l": "acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13043", "l": "5,6-dihydroxyindole-2-carboxylate => L-dopachrome", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52716", "l": "a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070338", "l": "5'-flap-structured DNA binding", "d": ["Binding to a 5'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 5'-end of DNA or RNA protrudes from a double-stranded DNA molecule. 5'-flap structures can be formed during DNA repair or lagging strand synthesis; in the latter case RNA flaps form from lagging strand RNA primers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49816", "l": "3 Fe(III)-[cytochrome c] + H2O + hydrazine = 3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide", "d": [], "t": []}, {"i": "EC:1.7.2.7", "l": "\"hydrazine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044685", "l": "tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: tetrahydromethanopterin + L-serine = 5,10-methylenetetrahydromethanopterin + glycine + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031789", "l": "G protein-coupled acetylcholine receptor binding", "d": ["Binding to a G protein-coupled acetylcholine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28535", "l": "dTTP + H2O => diphosphate + dTMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9834070", "l": "PRKN ubiquitinates MOM substrates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015576", "l": "sorbitol transmembrane transporter activity", "d": ["Enables the transfer of sorbitol from one side of a membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9815510", "l": "MIB2 binds CYLD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21812", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.23", "l": "\"cholesterol 7alpha-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0106019", "l": "phosphatidylinositol-4,5-bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47677", "l": "ATP + N-acetyl-D-galactosamine => ADP + H(+) + N-acetyl-D-galactosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9860264", "l": "TASL is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32934", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol <=> a cardiolipin + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58627", "l": "N-dodecanoyl-(2S)-hydroxyglycine <=> dodecanamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40771", "l": "(20S)-ginsenoside Rg1 + H2O = (20S)-ginsenoside F1 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68363", "l": "L-xylono-1,4-lactone + O2 <=> dehydro-L-arabinono-1,4-lactone + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341294", "l": "Superoxide reduces cytochrome c (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682967", "l": "WHSC1 binds DNA DSBs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78548", "l": "Rb(+)(in) => Rb(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23664", "l": "A + a (2R)-2-hydroxycarboxylate = a 2-oxocarboxylate + AH2", "d": [], "t": []}, {"i": "EC:1.1.99.30", "l": "\"2-oxo-acid reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55807", "l": "(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32410", "l": "(1R,2S,4S)-neoisodihydrocarveol + NAD(+) <=> (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47113", "l": "chenodeoxycholate + glycine => glycochenodeoxycholate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47052", "l": "(2E,6E)-farnesyl diphosphate = alpha-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48666", "l": "12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112430", "l": "Formation of P-TEFb complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177479", "l": "Axonal transport of NGF:Trk complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878914", "l": "B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168400", "l": "iE-DAP elicits a NOD1 response (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21498", "l": "diphosphate + prenol => dimethylallyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655170", "l": "RCHY1 monoubiquitinates POLH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375395", "l": "C5a receptor binds C5a anaphylatoxin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63522", "l": "3-isopropylcatechol + H2O + NAD(+) => 2-isopropylphenol + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63060", "l": "5-methylorsellinate + ATP + H(+) + NADPH = 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854408", "l": "APOBR dimer binds VLDLs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42439", "l": "L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-ascorbate 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54911", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH <=> (4E)-hexenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46118", "l": "D-glyceraldehyde + pyruvate => 2-dehydro-3-deoxy-D-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70288", "l": "1D-myo-inositol 3,4,6-trisphosphate + ATP => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46174", "l": "AMP + butanoyl-CoA + diphosphate => ATP + butanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11924", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a globoside Gb3Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.228", "l": "\"lactosylceramide 4-alpha-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.794758999417795", "identifiers": [{"i": "GO:0008484", "l": "sulfuric ester hydrolase activity", "d": ["Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2."], "t": []}, {"i": "EC:3.1.6.-", "l": "\"Sulfuric ester hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33693", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate => 2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38360", "l": "2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10 => thiosulfate + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58747", "l": "H2O + N(7)-methyl-GTP <=> diphosphate + H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759137", "l": "NFE2L2 and MAFK bind the HMOX1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41915", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADPH <=> hexadecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58471", "l": "2 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103111", "l": "protein-N(pi)-phosphohistidine--N-acetyl-D-glucosamine phosphotransferase activity", "d": ["Catalysis of the reaction: N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) = L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193642", "l": "Binding of pro-NGF to p75NTR:sortilin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200406", "l": "CPT1A,B transfers PALM to CAR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44295", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043854", "l": "cyclic nucleotide-gated mechanosensitive monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3782637", "l": "HDAC8 deacetylates histones (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15730", "l": "D-mannonate + NAD(+) => H(+) + keto-D-fructuronate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0052712", "l": "inositol phosphosphingolipid phospholipase activity", "d": ["Catalysis of the reaction: inositol phosphosphingolipid + H2O = sphingolipid + phosphorylinositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69853", "l": "a uridine in mRNA + H(+) + NADH => a 5,6-dihydrouridine in mRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70457", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2 => (6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24012", "l": "gamma-tocopherol + S-adenosyl-L-methionine = (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40484", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653974", "l": "Ragulator binds Rag dimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20133", "l": "3-(indol-3-yl)lactate + NAD(+) = H(+) + indole-3-pyruvate + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382053", "l": "Translocation of PDGF from ER to Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49847", "l": "(-)-dehydrodiconiferyl acid + a quinone <=> (-)-dehydrodiconiferyl acid ketone + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.120", "l": "\"L-fucono-1,5-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10728", "l": "GDP-6-deoxy-alpha-D-talose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74034", "l": "L-alanine(in) + L-cysteine(out) <=> L-alanine(out) + L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.235", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30696", "l": "3-aminopropanal + H2O + NAD(+) => beta-alanine + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55598", "l": "a globoside NORint + H(+) + UDP => a globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30790", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173740", "l": "Factor B binds to C3(H2O) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34069", "l": "diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37975", "l": "H(+) + homogentisate + phytyl diphosphate = 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.115", "l": "\"homogentisate phytyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31323", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.270", "l": "\"mannosylglucosyl-3-phosphoglycerate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706354", "l": "Ubiquitination of FLT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909732", "l": "Phosphorylation of STAT2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688834", "l": "ATXN3 binds VCP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53524", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995388", "l": "PP2A dephosphorylates BANF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45209", "l": "coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] => Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45122", "l": "H(+) + ipsdienone + NADH => (4R)-ipsdienol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35256", "l": "ATP + H2O + lipid A-core(in) => ADP + H(+) + lipid A-core(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693478", "l": "HTR1A binds HTR1A agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806974", "l": "MET dimers autophosphorylate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14004", "l": "choloyl-CoA + glycine <=> CoA + glycocholate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634391", "l": "SHC1 binds phosphorylated ERBB2 homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47209", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68345", "l": "ATP + GTP => 3',2'-cGAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046480", "l": "galactolipid galactosyltransferase activity", "d": ["Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41035", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787737", "l": "CSF3R binds CSF3 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434003", "l": "LPS binding to CD14 co-receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008200", "l": "NFE2 binds the beta globin locus control region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61075", "l": "(-)-(R)-19-hydroxytabersonine + acetyl-CoA <=> (-)-(R)-19-O-acetyltabersonine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139893", "l": "Granzyme-B activates BID by cleavage (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34413", "l": "cannabidiolate + H2O2 => cannabigerolate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30662", "l": "4-(phosphooxy)-L-threonine + H2O <=> 4-hydroxy-L-threonine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66057", "l": "indole-3-pyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43640", "l": "dodecanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.301", "l": "\"mycobacterial beta-ketoacyl-[acyl carrier protein] synthase III\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30496", "l": "N-hydroxy-L-valine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28335", "l": "dATP + H2O => dAMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67165", "l": "bromide + FADH2 + melleolide F + O2 => 6'-bromomelleolide F + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033164", "l": "glycolipid 1,6-alpha-mannosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36597", "l": "NADPH + sulfur => hydrogen sulfide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720478", "l": "Defective ALG9 does not add the seventh mannose to the N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18323", "l": "4-methyl-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72454", "l": "a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out) <=> a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34993", "l": "L-arginine(in) + L-ornithine(out) => L-arginine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45340", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = (9Z)-hexadecenoate + [Wnt protein]-L-serine + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.98", "l": "\"[Wnt protein] O-palmitoleoyl-L-serine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.752469279128519", "identifiers": [{"i": "GO:0016813", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2."], "t": []}, {"i": "EC:3.5.3.-", "l": "\"In linear amidines\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867613", "l": "PICALM binds R-SNAREs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601888", "l": "Unknown nuclease cleaves pre-piRNA in 4xMeR-PIWIL1:pre-piRNA:TDRD6:TDRKH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9613497", "l": "Unwinding DNA for the nascent transcript (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74791", "l": "(R)-salsolinol(in) = (R)-salsolinol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9706837", "l": "AR binds AR antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29483", "l": "(2E,6E)-farnesyl diphosphate = (+)-beta-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18669", "l": "adenosine + H2O = adenine + D-ribose", "d": [], "t": []}, {"i": "EC:3.2.2.7", "l": "\"adenosine nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42591", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044024", "l": "histone H2AS1 kinase activity", "d": ["Catalysis of the reaction: histone H2A-serine (position 1) + ATP = histone H2A-phosphoserine (position 1) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 1 of histone H2A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26321", "l": "resorcinol + S-adenosyl-L-methionine = 3-methoxyphenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.n1", "l": "\"resorcinol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759356", "l": "NFE2L2-dependent GSTA3 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669158", "l": "NF2 binds PAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23818", "l": "4-aminobutanal + L-glutamate => 2-oxoglutarate + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23150", "l": "ADP + propanoyl phosphate => ATP + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015131", "l": "oxaloacetate transmembrane transporter activity", "d": ["Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044687", "l": "geranylfarnesyl diphosphate synthase activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46014", "l": "a quinol + oxaloacetate => (S)-malate + a quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31059", "l": "H2O + imidazole-4-acetaldehyde + NAD(+) = 2 H(+) + imidazole-4-acetate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76857", "l": "H(+) + NADH + NH4(+) + pentan-2-one => 2-aminopentane + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3095889", "l": "MMACHC dealkylates RCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69580", "l": "dGMP + inosine = 2'-deoxyguanosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.32", "l": "\"stem bromelain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59041", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805109", "l": "CDK2 phosphorylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74711", "l": "Phosphorylation of IRS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24950", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + malonate => 3-hydroxy-3-methylglutarate + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12059", "l": "D-erythrose 4-phosphate + H2O + NAD(+) <=> 4-phospho-D-erythronate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755303", "l": "26S proteasome degrades HIFalpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16380", "l": "(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140033", "l": "acetylation-dependent protein binding", "d": ["Binding to a protein upon acetylation of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60420", "l": "H2O + triglucosyl-enterobactin = [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41836", "l": "H(+) + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73932", "l": "Resynthesis of excised residue by POLB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693540", "l": "MRN activates ATM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5685230", "l": "CHEK1 phosphorylates RAD51 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59014", "l": "24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine => cycloartenol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043874", "l": "acireductone synthase activity", "d": ["Catalysis of the reactions:5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390133", "l": "YKI transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66738", "l": "ADP + beta-citrylglutamate(out) + H(+) + phosphate => ATP + beta-citrylglutamate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052874", "l": "FMN reductase (NADH) activity", "d": ["Catalysis of the reaction: FMNH2 + NAD+ = FMN + NADH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48227", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside nLc4Cer(d18:1(4E)) + L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68914", "l": "DNA polymerase alpha:primase binds at the origin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59875", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37094", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(10Z,13Z,16Z)-docosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730882", "l": "Phosphorylation of PKC-theta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38998", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48391", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66991", "l": "4-methylpentanoate + ATP + CoA <=> 4-methylpentanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37123", "l": "sphing-4-enine + tetracosenoyl-CoA = CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9833635", "l": "p-PKR dimer localizes to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814374", "l": "Kazrin binds periplakin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191763", "l": "snRNP:Snurportin complex formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9853368", "l": "FIRRM binds FIGNL1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11075", "l": "anthranilate + 3 H(+) + NADPH + O2 <=> catechol + CO2 + NADP(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67153", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] => L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0005165", "l": "neurotrophin receptor binding", "d": ["Binding to a neurotrophin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27380", "l": "(R)-glycerate + ATP <=> (2R)-2-phosphoglycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661198", "l": "Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23274", "l": "an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP => an N(6)-alkylaminopurine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9708866", "l": "pro-F2R binds vorapaxar (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28032", "l": "[thioredoxin]-dithiol + GDP => [thioredoxin]-disulfide + dGDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.244991688848543", "identifiers": [{"i": "GO:0015605", "l": "organophosphate ester transmembrane transporter activity", "d": ["Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13817", "l": "[protein]-disulfide + H2O + phylloquinone = 2,3-epoxyphylloquinone + [protein]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62361", "l": "FMN-N(5)-peroxide + uracil => (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74887", "l": "2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6804099", "l": "HMGB1 binds LTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187661", "l": "Ade-Rib binds AODORA2A and NTRK1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56588", "l": "a monosubstituted aliphatic (S)-hydroxynitrile = an aldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24922", "l": "L-homoserine <=> 2-aminobut-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62781", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50881", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol => 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604831", "l": "NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928627", "l": "EPHB phosphorylates TIAM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.4", "l": "\"amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64890", "l": "AMP + diphosphate + tetradecanoyl-[ACP] => ATP + holo-[ACP] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23643", "l": "1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 <=> CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48920", "l": "ADP + bacteriochlorophyllide g + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate = 3,8-divinyl chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.14", "l": "\"3,8-divinyl chlorophyllide a reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6795290", "l": "TORC2 complex phosphorylates SGK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76045", "l": "2 H(+) + H2O + muramine + oxidized [NADPH--hemoprotein reductase] => (S)-cis-N-methyltetrahydropalmatine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17377", "l": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709109", "l": "DHFR dimer binds DHFR inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008756", "l": "o-succinylbenzoate-CoA ligase activity", "d": ["Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250280", "l": "ROS oxidize thioredoxin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37343", "l": "adenosine 2'-phosphate + H2O = adenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15538", "l": "(2R)-3-sulfolactate + NADP(+) => 3-sulfopyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796084", "l": "AcK-NFE2L2 binds the BCL2L1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:1990238", "l": "double-stranded DNA endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31609", "l": "all-trans-lycopene + H2O => rhodopin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45858", "l": "4-hydroxy-6-(2-hydroxytridecyl)-pyran-2-one + 2 CO2 + 3 CoA => 3-hydroxytetradecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418662", "l": "Src activation following P2Y purinoceptor activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018746", "l": "RHOQ binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52554", "l": "3-dehydro-4-O-phospho-L-erythronate + ADP + H(+) => 3-dehydro-L-erythronate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399969", "l": "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54946", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+) => 3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102390", "l": "mycophenolic acid acyl-glucuronide esterase activity", "d": ["Catalysis of the reaction: mycophenolic acid O-acyl-glucuronide(1-) + H2O = mycophenolate + H+ + D-glucopyranuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132233", "l": "Proteolytic cleavage of complement factor C4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13732", "l": "FAD <=> AMP + H(+) + riboflavin cyclic-4',5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49606", "l": "2-glutathionyl-2-methylbut-3-enal + H(+) + NADH => 2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33057", "l": "diphosphate + GTP + H(+) => guanosine 3'-diphosphate 5'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11737", "l": "2-exo-hydroxy-1,8-cineole + NAD(+) => 6-oxocineole + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.28", "l": "\"bacillolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13635", "l": "ADP + gamma-L-glutamylputrescine + H(+) + phosphate => ATP + L-glutamate + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936378", "l": "Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653974", "l": "Ragulator binds Rag dimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35898", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854222", "l": "TBC1D3 associates with RAB5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18117", "l": "L-tyrosine + O2 = H2O + L-dopaquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55559", "l": "a hydroperoxyeicosatetraenoate <=> an oxoeicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592362", "l": "Activation of proMMP7 by MMP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78522", "l": "H2O + N-acetyl-2,7-anhydro-alpha-neuraminate <=> N-acetyl-alpha-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25986", "l": "(5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72567", "l": "dehydroepiandrosterone 3-sulfate(in) + propanoate(out) = dehydroepiandrosterone 3-sulfate(out) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681294", "l": "IL6R binds IL6R inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70225", "l": "2-oxobutanoate + L-glutamate => (2S)-2-aminobutanoate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27702", "l": "aldehydo-D-galacturonate = keto-D-tagaturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70592", "l": "PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211191", "l": "Association of DFF with alpha:beta importin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851933", "l": "MET phosphorylates GAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19914", "l": "a (3R)-hydroxyacyl-[ACP] + NAD(+) => a 3-oxoacyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047627", "l": "adenylylsulfatase activity", "d": ["Catalysis of the reaction: 5'-adenylyl sulfate + H2O = AMP + 2 H+ + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660752", "l": "USP9X deubiquitinates Ub-SNCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237129", "l": "Acireductone is created (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71605", "l": "2-oxoglutarate(in) + oxaloacetate(out) => 2-oxoglutarate(out) + oxaloacetate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693583", "l": "MDC1 associates with gamma-H2AFX at nuclear foci (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63665", "l": "(8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADPH => H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168638", "l": "Activated IKK phosphorylates I-kappaB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26039", "l": "beta-D-fructose 6-phosphate + GDP-alpha-D-mannose = beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.246", "l": "\"mannosylfructose-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43434", "l": "butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) => butan-1-ol + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14541", "l": "choloyl-CoA + H2O = cholate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37739", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19114", "l": "(8Z,11Z,14Z)-heptadecatrienal + A + H2O => (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75891", "l": "Abortive Initiation After Second Transition (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16541", "l": "9-cis-violaxanthin + O2 = (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51507", "l": "a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose <=> a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33112", "l": "(2E,6E)-farnesyl diphosphate => beta-copaene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050162", "l": "oxalate oxidase activity", "d": ["Catalysis of the reaction: 2 H+ + O2 + oxalate = 2 CO2 + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36115", "l": "gibberellin A3 + S-adenosyl-L-methionine = O-methyl gibberellin A3 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72060", "l": "glycochenodeoxycholate(out) + 2 Na(+)(out) => glycochenodeoxycholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428664", "l": "SGPP1,2 dephosphorylate sphingoid-1-phosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419003", "l": "Interaction of Nectins with Afadin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69473", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose => a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45102", "l": "mitomycin B + S-adenosyl-L-homocysteine => 6-demethylmitomycin B + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73800", "l": "SAICAR => AICAR + Fumarate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32773", "l": "2,6-dioxo-6-phenylhexa-3-enoate => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021851", "l": "MECP2 binds CREB1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17331", "l": "(1R,4R)-camphor + H(+) + NADH => (1R,2S,4R)-borneol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65545", "l": "a ganglioside GM1 + H2O => an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70219", "l": "corticosterone + H(+) + NADPH = 20beta-dihydrocorticosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018819", "l": "lactoyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047684", "l": "arylamine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0045513", "l": "interleukin-27 binding", "d": ["Binding to interleukin-27."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68077", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP => a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72970", "l": "4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) <=> 4-methyl-2-oxopentanoate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13597", "l": "1,4-diguanidinobutane + H2O = agmatine + urea", "d": [], "t": []}, {"i": "EC:3.5.3.20", "l": "\"diguanidinobutanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25112", "l": "H2O + pyridoxine 5'-phosphate = phosphate + pyridoxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951644", "l": "Release of mature NEDD8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444171", "l": "Receptor FFAR2 binds carboxylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052692", "l": "raffinose alpha-galactosidase activity", "d": ["Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28380", "l": "ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine => ATP + N(6)-(D-fructosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59326", "l": "D-xylono-1,5-lactone + H2O2 => D-xylose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624956", "l": "PDE6D binds INPP5E (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428664", "l": "SGPP1,2 dephosphorylate sphingoid-1-phosphates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140394", "l": "ABC-type azole transporter activity", "d": ["Enables the transfer of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other according to the reaction: ATP + H2O + azole(in) = ADP + phosphate + azole(out)."], "t": []}, {"i": "RHEA:33503", "l": "ATP + H2O + itraconazole(in) = ADP + H(+) + itraconazole(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50549", "l": "prostaglandin E1 => H2O + prostaglandin A1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2152276", "l": "Secretion of transmembrane collagens (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708866", "l": "pro-F2R binds vorapaxar (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043781", "l": "cobalt-factor II C20-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64723", "l": "H(+)(out) + pyruvate(out) <=> H(+)(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429101", "l": "HMIT co-transports myo-inositol with a proton (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29882", "l": "ATP + H2O + L-arginine(out) <=> ADP + H(+) + L-arginine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62355", "l": "H(+) + NADPH + notoamide E + O2 <=> H2O + NADP(+) + notoamide D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22965", "l": "H(+) + L-ornithine => CO2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41469", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694401", "l": "E protein gets palmitoylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106238", "l": "peregrinol diphosphate synthase activity", "d": ["Catalysis of the reaction:peregrinol diphosphate = all-trans-geranylgeranyl diphosphate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47026", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+) => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14741", "l": "4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.67", "l": "\"4-methyleneglutaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15332", "l": "(S)-ureidoglycolate + NAD(+) <=> H(+) + N-carbamoyl-2-oxoglycine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938217", "l": "RUNX1 binds the SWI/SNF complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76079", "l": "a dicarboxylate(in) + L-sepiapterin(out) = a dicarboxylate(out) + L-sepiapterin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68614", "l": "NADP(+) + prostaglandin F1 => H(+) + NADPH + prostaglandin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000137", "l": "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2974737", "l": "NOTCH2 binds MDK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12848", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O <=> [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59629", "l": "H2O + N(2)-(4-aminobutanoyl)-L-arginine => 4-aminobutanoate + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.098100396370043", "identifiers": [{"i": "GO:0008168", "l": "methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67297", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 => (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36405", "l": "a fatty acid + cholesterol + H(+) => a cholesterol ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613497", "l": "Unwinding DNA for the nascent transcript (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.86", "l": "\"N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141096", "l": "ligand-activated transcription repressor activity", "d": ["A DNA-binding transcription repressor activity regulated by binding to a ligand and that inhibits the transcription of specific genes and gene sets."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422320", "l": "Heterotrimeric G(s) complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18817", "l": "acetyl-CoA + malonate = acetate + malonyl-CoA", "d": [], "t": []}, {"i": "EC:2.8.3.3", "l": "\"malonate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009012", "l": "aminoglycoside 3''-adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + streptomycin = 3''-adenylylstreptomycin + diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35367", "l": "(2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH = isoheptadecanoyl-coA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24765", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34296", "l": "2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose => 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8857686", "l": "FITM1, FITM2 bind TAGs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034202", "l": "glycolipid floppase activity", "d": ["Catalysis of the movement of a glycolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26544", "l": "(R)-piperazine-2-carboxylate + NH4(+) => (R)-piperazine-2-carboxamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39375", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA = (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18346", "l": "a cis-3-alkyl-4-alkyloxetan-2-one => a cis-alkene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204549", "l": "Caveolin-1 binds Basigin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209921", "l": "Monoiodinated tyrosine can be deiodinated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34247", "l": "1-deoxymethyl-sphinganine + NADP(+) = 1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28017", "l": "S-adenosyl-L-methionine + thiocyanate <=> methyl thiocyanate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004131", "l": "cytosine deaminase activity", "d": ["Catalysis of the reaction: cytosine + H2O = uracil + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29871", "l": "ATP + H2O + thiosulfate(out) = ADP + H(+) + phosphate + thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68888", "l": "2-methoxybenzoate + ATP + H(+) + NADPH = 2-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38176", "l": "all-trans-retinol + hexadecanoyl-CoA => all-trans-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982792", "l": "Growth hormone receptor binds JAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694521", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52677", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O => [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49998", "l": "(25R)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080108", "l": "S-alkylthiohydroximate lyase activity", "d": ["Catalysis of the conversion of a S-alkylthiohydroximate to a thiohydroximate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72005", "l": "(S)-lactate(out) + urate(in) => (S)-lactate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47506", "l": "3-oxochenodeoxycholate + H(+) + NADPH => chenodeoxycholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77080", "l": "2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane carbocation + N,N-dimethyl-cadaverine => H(+) + pre-flavunoidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424485", "l": "Release of p-PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70589", "l": "acetate + alpha-D-glucosaminyl-[heparan sulfate](n) => H2O + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35888", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12612", "l": "mercaptopurine + S-adenosyl-L-methionine <=> 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27582", "l": "(S)-2-hydroxymethylglutarate = 2-methyleneglutarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28650", "l": "acetophenone + 2 ATP + H2O + hydrogencarbonate <=> 3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19771", "l": "H2O + phaseollidin => phaseollidin hydrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732729", "l": "Activated JAK1 binds RAF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46074", "l": "hexadecanoyl-CoA + NAD(+) => (2E)-hexadecenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42233", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58991", "l": "(E)-4-hydroxynon-2-enal + H2O + O2 <=> (E)-4-hydroxynon-2-enoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9619756", "l": "NR1H2 binds ABCA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78884", "l": "6-O-methyl-N-deacetylipecoside + H2O => 6-O-methyl-N-deacetylipecoside aglycone + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55668", "l": "11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12287", "l": "3-hydroxy-3-methylglutarate + succinyl-CoA <=> (3S)-hydroxy-3-methylglutaryl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21959", "l": "UDP-alpha-D-glucose + vitexin <=> H(+) + UDP + vitexin 2''-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047660", "l": "amidinoaspartase activity", "d": ["Catalysis of the reaction: N-amidino-L-aspartate + H2O = L-aspartate + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70973", "l": "3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+) => D-dopa + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029680", "l": "Caspase-7 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062153", "l": "C5-methylcytidine-containing RNA reader activity", "d": ["A protein adaptor that recognizes and binds an RNA molecule modified by C5-methylcytidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19597", "l": "H2O + L-arginine = L-citrulline + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.3.6", "l": "\"arginine deiminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19274", "l": "H2O + N-acetyl-D-mannosamine + phosphoenolpyruvate => N-acetylneuraminate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807872", "l": "Active ARF recruits coatomer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21012", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}, {"i": "EC:2.4.1.70", "l": "\"poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16334", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] => diphosphate + holo-[citrate lyase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42926", "l": "2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11820", "l": "diphthamide-[translation elongation factor 2] + NAD(+) = H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide", "d": [], "t": []}, {"i": "EC:2.4.2.36", "l": "\"NAD(+)--diphthamide ADP-ribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39817", "l": "(R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23919", "l": "H(+) + UDP-alpha-D-glucuronate <=> CO2 + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.5.-", "l": "\"Triphosphoric monoester hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44971", "l": "(2E)-tetradecenoyl-CoA + H(+) + NADPH <=> NADP(+) + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30474", "l": "(2Z,6Z)-farnesyl diphosphate <=> (1S,5S,6S)-alpha-bergamotene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.41", "l": "\"pullulanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791075", "l": "Expression of DNAJB11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797553", "l": "Protein 4.1 binds CASK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72857", "l": "ADP(in) + dADP(out) => ADP(out) + dADP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31320", "l": "(2R)-3-phosphoglycerate + UDP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52504", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = (9R)-hydroxy-(10E,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855648", "l": "SALM3 binds LAR-RPTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64743", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine <=> 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070182", "l": "DNA polymerase binding", "d": ["Binding to a DNA polymerase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58249", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O => ADP-D-ribose + H(+) + L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70741", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76428", "l": "(2R,9S)-annullatin H + A => (2R)-annullatin F + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1170539", "l": "Prolactin receptor is internalized (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75184", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + lydicene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004609", "l": "phosphatidylserine decarboxylase activity", "d": ["Catalysis of the reaction: H+ + phosphatidyl-L-serine = CO2 + phosphatidylethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840581", "l": "GM1 localizes to endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019170", "l": "methylglyoxal reductase (NADH) activity", "d": ["Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166387", "l": "The FA anion diffuses away laterally from UCP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14343", "l": "2-hydroxy-3-oxoadipate + CO2 => 2-oxoglutarate + glyoxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844015", "l": "MPHOSPH8 (MPP8) in HUSH complex binds histone H3 trimethyl-lysine 9 (H3K9me3) in L1HS,L1PA2,3 heterochromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42096", "l": "ATP + carbamoyl phosphate + H2O + tobramycin = AMP + diphosphate + H(+) + nebramycin 5' + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41042", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57184", "l": "L-cysteinyl-[protein] + methylglyoxal = S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070539", "l": "linoleic acid binding", "d": ["Binding to linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793666", "l": "MDM2 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762345", "l": "PREDN:ALB dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0072328", "l": "alkene binding", "d": ["Binding to an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40308", "l": "A + decanedioyl-CoA => (2E)-decenedioyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61425", "l": "cis-cis-nepetalactol + NAD(+) => cis-cis-nepetalactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029468", "l": "Conversion of PA into DAG by PAP-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54073", "l": "(2E)-geranyl diphosphate => beta-thujene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084912", "l": "Arresten binds integrin alpha1beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72531", "l": "ATP + H2O + methyl beta-D-galactoside(out) = ADP + H(+) + methyl beta-D-galactoside(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802973", "l": "PLK3 phosphorylates CDC25C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9660557", "l": "RAS:GTP binds RAL GDS proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396370", "l": "VTN binds collagens II, III and V (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448958", "l": "Nuclear translocation of p38 MAPK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112037", "l": "Inactivation of PLC beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248677", "l": "Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694462", "l": "ABHD6,12 hydrolyse 3AG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166817", "l": "Cleavage of C3 by C3 convertases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71639", "l": "K(+)(in) + Na(+)(in) = K(+)(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350058", "l": "Formation of CSL NCOR corepressor complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197958", "l": "FPGS-2 transforms THF to THFPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18247", "l": "ADP + CoA + H(+) => 3'-dephospho-CoA + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55672", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}, {"i": "EC:2.4.1.355", "l": "\"poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047600", "l": "abequosyltransferase activity", "d": ["Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019772", "l": "low-affinity IgG receptor activity", "d": ["Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36553", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+) => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77490", "l": "4-methylpentan-2-one + hydrogen cyanide <=> (2S)-2-hydroxy-2,4-dimethylpentanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29248", "l": "3 H(+)(out) + 2 Na(+)(in) => 3 H(+)(in) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58944", "l": "6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH = 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.290", "l": "\"spectinabilin polyketide synthase system\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.31", "l": "\"L-aminoadipate-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372819", "l": "PCK2 phosphorylates OA to yield PEP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028724", "l": "AMOT proteins bind YAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12167", "l": "3'-phosphoadenylyl sulfate + a phenol <=> adenosine 3',5'-bisphosphate + an aryl sulfate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58584", "l": "dihydroprecondylocarpine acetate = (-)-tabersonine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.19", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39679", "l": "(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13468", "l": "(S)-2,3-diaminopropanoate + oxalyl-CoA <=> CoA + N(3)-oxalyl-L-2,3-diaminopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704248", "l": "CHRM4 binds CHRM4 antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41538", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine => 2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35961", "l": "demethoxyfumitremorgin C + 2 H2O + NADP(+) => H(+) + NADPH + O2 + tryprostatin B", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34731", "l": "15-methylhexadecasphing-4-enine + a fatty acyl-CoA = CoA + H(+) + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22601", "l": "H2O + N-acetyl-9-O-acetylneuraminate => acetate + H(+) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098604", "l": "adenosylselenohomocysteinase activity", "d": ["Catalysis of the reaction: Se-Adenosyl-L-selenohomocysteine + H2O => Adenosine + Selenohomocysteine."], "t": []}, {"i": "REACT:R-HSA-2408532", "l": "AdeSeHCys is hydrolysed to SeHCys by AHCY (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042962", "l": "acridine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52246", "l": "2 H2O + 4 Mn(3+) => 4 H(+) + 4 Mn(2+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21029", "l": "acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49431", "l": "CTP + phosphonoformate <=> CMP-5'-phosphonoformate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67628", "l": "ATP + dGMP + L-aspartate = (2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.25", "l": "\"2-amino-2'-deoxyadenylo-succinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12838", "l": "ATP + choline => ADP + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210271", "l": "Interaction of DAP12 and MDL-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381091", "l": "IRE1 dimer autophosphorylates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681294", "l": "IL6R binds IL6R inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28126", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose = alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.31", "l": "\"undecaprenyl-phosphate glucose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047135", "l": "bis-gamma-glutamylcystine reductase activity", "d": ["Catalysis of the reaction: 2 L-gamma-glutamyl-L-cysteine + NADP+ = bis-gamma-glutamylcystine + H+ + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76090", "l": "a dicarboxylate(in) + kynurenate(out) <=> a dicarboxylate(out) + kynurenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10202", "l": "(2E)-2-butenoate + H(+) + NADH => butanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374896", "l": "Uptake of Noradrenaline (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19475", "l": "3,4-dihydroxybenzoate + H2O + NAD(+) => 4-hydroxybenzoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788999", "l": "HV1-mediated H+ transfer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58650", "l": "H(+) + rifamycin SV ortho-naphthoquinone carboxamide => rifamycin SV hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.73", "l": "\"u-plasminogen activator\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10542", "l": "6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde => 7,8-dihydroneopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700175", "l": "Active ALK phosphorylates SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43805", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866941", "l": "MID1IP1 binds THRSP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019875", "l": "6-aminohexanoate-dimer hydrolase activity", "d": ["Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18044", "l": "2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] <=> 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66520", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944457", "l": "MAF1 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17086", "l": "4-pyridoxate + A => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187506", "l": "Translocation of p27 to the nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692764", "l": "MAPK6 binds CCND3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36276", "l": "H(+) + NADPH + O2 + theophylline => 3-methylxanthine + formaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54215", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 <=> 2-(prostaglandin G2)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.3", "l": "\"nitrate reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21692", "l": "CDP-glycerol + H2O = CMP + 2 H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.16", "l": "\"CDP-glycerol diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.94", "l": "\"proprotein convertase 2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27525", "l": "2,5-dihydroxypyridine + O2 <=> H(+) + N-formylmaleamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76179", "l": "a dipeptide(out) + 2 H(+)(out) = a dipeptide(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102716", "l": "gibberellin A28,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A28 + 2-oxoglutarate + O2 = (2betaOH)-gibberellin28 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709360", "l": "H2O2 reduces MetHb (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16829", "l": "an aldehyde + H2O + O2 = a carboxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14904", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> casbene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989760", "l": "Expression of HMGCS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59956", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate = a nitrile + sulfate + sulfur", "d": [], "t": []}, {"i": "EC:4.8.1.5", "l": "\"thiohydroximate-O-sulfate sulfate/sulfur-lyase (nitrile-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757574", "l": "ALB binds PREDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17135", "l": "ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase] => ATP + L-seryl-[tyrosine-3-monooxygenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937792", "l": "RUNX3 binds SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "58.523201664253619", "identifiers": [{"i": "GO:0016741", "l": "transferase activity, transferring one-carbon groups", "d": ["Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.1.-.-", "l": "\"Transferring one-carbon groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.3.2.3", "l": "\"ABC-type sulfate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32471", "l": "demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] = (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.66", "l": "\"marmesin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9825751", "l": "HINT1 binds MITF-M (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54309", "l": "pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205286", "l": "GRB2:SOS interacts with p-KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909724", "l": "Recruitment of IFNAR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170964", "l": "FRS2 binds to active TrkA receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71602", "l": "2-oxoglutarate(out) + maleate(in) <=> 2-oxoglutarate(in) + maleate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38218", "l": "D-glucose 6-phosphate + NAD(+) <=> 6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031863", "l": "prostaglandin D2 receptor binding", "d": ["Binding to a prostaglandin D2 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011543", "l": "DCA binds PDK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428749", "l": "Activated TP receptor binds G-proten Gq (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42565", "l": "uridine(38/39) in tRNA => pseudouridine(38/39) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508513", "l": "PTK2B binds JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940561", "l": "MMP7 cleaves OPTC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10999", "l": "2-methylpropanal oxime + S-adenosyl-L-methionine <=> 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59495", "l": "(2E)-geranyl diphosphate + L-tryptophyl-[protein] <=> (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043431", "l": "2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799097", "l": "ATM phosphorylates ZNF420 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21739", "l": "(3S)-3,6-diaminohexanoate <=> (3S,5S)-3,5-diaminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52532", "l": "adenosine + GTP = AMP + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213239", "l": "Formation of MHC II alpha beta heterodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817269", "l": "DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031694", "l": "alpha-2A adrenergic receptor binding", "d": ["Binding to an alpha-2A adrenergic receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035279", "l": "Expression of APOC4 regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633314", "l": "TP53 stimulates NDRG1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68971", "l": "mandelate + O2 <=> H2O2 + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870469", "l": "RGGT geranylgeranylates RAB proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102134", "l": "(22S)-22-hydroxy-campesterol C-23 hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 = (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696266", "l": "RND2 binds effectors (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40192", "l": "(3R)-hydroxyoctanoyl-CoA + NAD(+) => 3-oxooctanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29364", "l": "dCMP + H2O => 2'-deoxycytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944216", "l": "Association of procollagen type XV (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322429", "l": "XIAP monoubiquinates TLE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73945", "l": "FAS-mediated dimerization of procaspase-8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17620", "l": "leukotriene C4 <=> glutathione + leukotriene A4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69142", "l": "Recruitment of Dna2 endonuclease (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626034", "l": "EEF1A1 dissociates from p-GFAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60077", "l": "4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2 => 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54672", "l": "(+)-kolavenyl diphosphate + H2O = (+)-kolavelool + diphosphate", "d": [], "t": []}, {"i": "EC:3.1.7.12", "l": "\"(+)-kolavelool synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183126", "l": "Factor B binds to surface-associated C3b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69486", "l": "dodecanal + H2O2 => dodecan-1-ol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16297", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.210", "l": "\"3beta-(or 20alpha)-hydroxysteroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57105", "l": "[(1->4)-alpha-D-galacturonosyl](n) => 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61772", "l": "rebaudioside E + UDP-alpha-D-glucose = H(+) + rebaudioside D + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28840", "l": "H(+)(out) + Zn(2+)(in) => H(+)(in) + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814096", "l": "ARL1:GTP binds SCOC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47672", "l": "H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) = 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76491", "l": "(E)-ferulate + H2O = acetate + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37040", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 => 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50004", "l": "H(+) + NADPH + O2 + tetracycline = 11a-hydroxytetracycline + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.231", "l": "\"tetracycline 11a-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.14", "l": "\"N-acyl-aliphatic-L-amino acid amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1222376", "l": "NOX2 generates superoxide from oxygen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-708349", "l": "Activated NOD2 oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0000182", "l": "rDNA binding", "d": ["Binding to a DNA sequence encoding a ribosomal RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061662", "l": "ISG15 ligase activity", "d": ["Catalysis of the transfer of a ISG15 to a substrate protein via the reaction X-ISG15 + S = X + S-ISG15, where X is either an E2 or E3 enzyme, the X-ISG15 linkage is a thioester bond, and the S-ISG15 linkage is an isopeptide bond between the C-terminal amino acid of ISG15 and the epsilon-amino group of lysine residues in the substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694522", "l": "Inner coat assembly and cargo binding (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32858", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052681", "l": "alpha-bisabolene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031386", "l": "protein tag activity", "d": ["A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052913", "l": "16S rRNA (guanine(966)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(966) in 16S rRNA = N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70796", "l": "H(+)(in) + L-lysine(out) => H(+)(out) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.484625558868103", "identifiers": [{"i": "GO:0019955", "l": "cytokine binding", "d": ["Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692738", "l": "HRH2 binds HRH2 antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21503", "l": "UDP-alpha-D-glucose <=> H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62033", "l": "a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O => a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10972", "l": "a D-hexose + H(+) + phosphoramidate = alpha-D-hexose 1-phosphate + NH4(+)", "d": [], "t": []}, {"i": "EC:2.7.1.62", "l": "\"phosphoramidate--hexose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61173", "l": "myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48178", "l": "(2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein] => decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40076", "l": "6-amino-6-deoxyfutalosine + H(+) + H2O => futalosine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43260", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73907", "l": "4-hydroxy-N,N,N-trimethyltryptamine + ATP = ADP + aeruginascin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799409", "l": "HIPK2 phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39680", "l": "(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14136", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46401", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59405", "l": "L-homoserine => D-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730856", "l": "Autophosphorylation of PAK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27763", "l": "CTP + H2O => CMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874979", "l": "ACBD3 binds GOLGB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27326", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614816", "l": "Latent Transcriptinally Repressed HCMV Genome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62751", "l": "H2O + lovastatin <=> (S)-2-methylbutanoate + H(+) + monacolin J", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0003958", "l": "NADPH-hemoprotein reductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102148", "l": "N-acetyl-beta-D-galactosaminidase activity", "d": ["Catalysis of the reaction: H2O + an N-acetyl-beta-D-galactosalaminyl-[glycan] = N-acetyl-beta-D-galactosamine + a glycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54150", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O => 1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31363", "l": "NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n) = 2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}, {"i": "EC:1.5.1.40", "l": "\"8-hydroxy-5-deazaflavin:NADPH oxidoreductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44200", "l": "12-methyloctadecanoate + ATP + CoA = 12-methyloctadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12177", "l": "phenylethanolamine + S-adenosyl-L-methionine => H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70971", "l": "ACO2 isomerizes citrate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66569", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O => preluffariellolide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25606", "l": "2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O => 2-(3-methylsulfanyl)propylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62688", "l": "4 norrubrofusarin + O2 = 2 H2O + 2 ustilaginoidin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686625", "l": "LAIR1 binds collagen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21951", "l": "formamide + H2O <=> formate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56768", "l": "2 AH2 + all-trans-zeaxanthin + 2 O2 = 2 A + all-trans-adonixanthin + 3 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20934", "l": "dihydroxyacetone phosphate + formaldehyde => L-erythrulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050336", "l": "thioethanolamine S-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + cysteamine = S-acetylcysteamine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31874", "l": "(S)-2,3-epoxysqualene <=> alpha-seco-amyrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43769", "l": "an alkylamine + L-glutaminyl-[protein] => N(5)-alkyl-L-glutaminyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113705", "l": "RNA Polymerase III Productive Transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52712", "l": "dTMP + H2O = 2-deoxy-D-ribose 5-phosphate + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12463", "l": "(S)-malate <=> fumarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21006", "l": "2-dehydropantolactone + AH2 => (R)-pantolactone + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879930", "l": "STAT5 is recruited by JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53939", "l": "O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2 <=> 19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654511", "l": "FGFRL1 dimer binds FGFs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72953", "l": "butanoate(in) + 2 Na(+)(in) => butanoate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156678", "l": "Activation of Cdc25C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018858", "l": "benzoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418091", "l": "F2R binds ARRB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429101", "l": "HMIT co-transports myo-inositol with a proton (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19504", "l": "4-guanidinobutanoate + H2O <=> 4-aminobutanoate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77540", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA => 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008684", "l": "TBK1 phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.41", "l": "\"cathepsin F\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12720", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482772", "l": "Release of platelet cytosolic components (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52632", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP", "d": [], "t": []}, {"i": "EC:2.7.2.19", "l": "\"[amino-group carrier protein]-L-glutamate 6-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71287", "l": "phosphocreatine + H2O => creatinine + orthophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167459", "l": "Abortive  termination of HIV-1 elongation after arrest (Tat-containing elongation complex) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71578", "l": "5-phosphomethyl-dUMP in DNA + putrescine <=> 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23156", "l": "(E)-(indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H2O", "d": [], "t": []}, {"i": "EC:4.8.1.3", "l": "\"indoleacetaldoxime dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52460", "l": "17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62635", "l": "a hydroperoxide + 2 glutathione <=> an alcohol + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16600", "l": "ATP + NH4(+) + UTP <=> ADP + CTP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193068", "l": "CYP17A1 17-hydroxylates PREG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47625", "l": "cis-3-hydroxy-L-proline => 1-pyrroline-2-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24499", "l": "4-O-deacetylvindoline + acetyl-CoA <=> CoA + vindoline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40840", "l": "FAD + H(+) + nonanoyl-CoA => (2E)-nonenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55103", "l": "3-oxopentanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxypentanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114544", "l": "p115-RhoGEF activation of RHOA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17441", "l": "2-oxoglutarate + L-cysteine = 2-oxo-3-sulfanylpropanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.3", "l": "\"cysteine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36347", "l": "N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine", "d": [], "t": []}, {"i": "EC:4.1.3.44", "l": "\"tRNA 4-demethylwyosine synthase (AdoMet-dependent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30544", "l": "(S)-carnitine + ATP + CoA => (S)-carnitinyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109701", "l": "PDPK1 binds PIP3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110307", "l": "REV1 binds AP-dsDNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679045", "l": "C-ter TLR9 dimer binds HCQ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66240", "l": "ATP + CoA + IC-asc-C9 = AMP + diphosphate + IC-asc-C9-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48308", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O = (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)", "d": [], "t": []}, {"i": "EC:4.1.2.44", "l": "\"2,3-epoxybenzoyl-CoA dihydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700168", "l": "Active ALK phosphorylates IRS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63965", "l": "sphinga-4E,14Z-dienine-1-phosphate => (2E,12Z)-hexadecadienal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008966", "l": "phosphoglucosamine mutase activity", "d": ["Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70884", "l": "H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out) => H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848818", "l": "PTK6 phosphorylates CBL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43175", "l": "guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73506", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine <=> 3',4,7-trihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420688", "l": "GABAB heterodimeric receptor binds GABA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20908", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.225", "l": "\"N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58100", "l": "1-(15Z-tetracosenoyl)-glycerol + H2O = (15Z)-tetracosenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14854", "l": "4-chlorobenzoyl-CoA + H2O => 4-hydroxybenzoyl-CoA + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804100", "l": "HMGB1 binds LPS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24258", "l": "ADP + H(+) + kanamycin 3'-phosphate => ATP + kanamycin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53438", "l": "19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17296", "l": "2 H(+) + NADH + O2 + precorrin-3A <=> H2O + NAD(+) + precorrin-3B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60019", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquisabinene B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13787", "l": "H2O + itaconyl-CoA => (3S)-citramalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62387", "l": "cyclic (2R)-2,3-bisphosphoglycerate + H2O <=> (2R)-2,3-bisphosphoglycerate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24164", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]", "d": [], "t": []}, {"i": "EC:1.8.4.12", "l": "\"peptide-methionine (R)-S-oxide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985153", "l": "OASL binds DDX58 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22025", "l": "H2O + NAD(+) + trimethylamine => 2 H(+) + NADH + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34519", "l": "N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine = [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP", "d": [], "t": []}, {"i": "EC:2.4.1.292", "l": "\"GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30301", "l": "a nucleobase within DNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + a methylated nucleobase within DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76698", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione <=> (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695831", "l": "FLT3 binds type II TKI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047064", "l": "sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity", "d": ["Catalysis of the reaction: O2 + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57738", "l": "AH2 + all-trans-3,4-didehydroretinol => A + all-trans-3,4-didehydro-13,14-dihydroretinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50566", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67418", "l": "(1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47079", "l": "17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH <=> 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21419", "l": "NADP(+) + sn-glycerol 1-phosphate <=> dihydroxyacetone phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68208", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol = 1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379387", "l": "COMT transfers Met to DA to form 3MT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847880", "l": "CYTH proteins bind ARF1:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61840", "l": "brassicasterol + UDP-alpha-D-glucose = brassicasterol 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25636", "l": "laricitrin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + syringetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009007", "l": "site-specific DNA-methyltransferase (adenine-specific) activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665698", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849906", "l": "SALM1 binds NMDA receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59310", "l": "D-galactonate + H(+) => D-galactono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52340", "l": "a long-chain fatty acyl-AMP + holo-[mycocerosate synthase] = AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10711", "l": "alpha-D-glucose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030942", "l": "endoplasmic reticulum signal peptide binding", "d": ["Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167121", "l": "Addition of the third nucleotide on the nascent HIV-1 transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16397", "l": "2 D-glucopyranose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate", "d": [], "t": []}, {"i": "EC:2.7.1.41", "l": "\"glucose-1-phosphate phosphodismutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849878", "l": "PSD-95 binds NMDA receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11183", "l": "ATP + L-asparagine + tRNA(Asn) <=> AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36936", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247847", "l": "WLS is endocytosed to the early endosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76431", "l": "Na(+)(out) + NH4(+)(in) = Na(+)(in) + NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65365", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O => a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671702", "l": "AP1G2 binds HGS and CHMP2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11638", "l": "15-oxoprostaglandin E1 + H(+) + NADPH => NADP(+) + prostaglandin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210294", "l": "Interaction of PECAM-1 and SHP-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004052", "l": "arachidonate 12(S)-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655268", "l": "Activated FGFR2 mutants phosphorylate FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69158", "l": "acrolein + N-(4-aminobutyl)-3-aminopropanal => spermine dialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40467", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67459", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661230", "l": "MT1A binds arsenic (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28635", "l": "(2E,6E)-farnesyl diphosphate = (+)-5-epi-aristolochene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.61", "l": "\"5-epiaristolochene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29206", "l": "dimethyl sulfoxide + menaquinol-8 <=> dimethyl sulfide + H2O + menaquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20278", "l": "acetyl-CoA + an N-hydroxyarylamine => an N-acetoxyarylamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61248", "l": "H2O + L-tyrosine + O2 = 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428273", "l": "SPHK1 phosphorylates sphingoid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56563", "l": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose <=> [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5681980", "l": "ATG12 binds ATG7 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9825790", "l": "p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603419", "l": "Activated NTRK3 binds SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65558", "l": "an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc => a globoside GalGb4Cer + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9861667", "l": "DLAT trimer transfers acetyl to CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008414", "l": "CDP-alcohol phosphotransferase activity", "d": ["Catalysis of the transfer of a CDP-alcohol group from one compound to another."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450187", "l": "TAK1 is activated within the TAK1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952996", "l": "E2F7 forms homodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63346", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40784", "l": "docosanoyl-CoA + H2O => CoA + docosanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72672", "l": "The 60S subunit joins the translation initiation complex  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750666", "l": "ALB binds ST (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798304", "l": "TP53 binds the E2F7 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50147", "l": "ethyl (9Z)-hexadecenoate + H2O <=> (9Z)-hexadecenoate + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66680", "l": "ATP + coproporphyrinogen III(in) + H2O = ADP + coproporphyrinogen III(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5688797", "l": "ATXN3 family cleave Ub chains (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16164", "l": "2 Fe(III)-[leghemoglobin] + NADH <=> 2 Fe(II)-[leghemoglobin] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672817", "l": "Active MTORC1 binds the ULK1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51840", "l": "2 Na(+)(out) + tauroallocholate(out) = 2 Na(+)(in) + tauroallocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25823", "l": "H2O + O2 + spermidine <=> 4-aminobutanal + H2O2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047219", "l": "monoterpenol beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl beta-D-glucoside + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981832", "l": "NMUR2 binds neuromedin-S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76373", "l": "n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) => n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805059", "l": "CK2:FACT phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62782", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68781", "l": "(2Z,6Z)-farnesyl diphosphate => alpha-humulene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13325", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate", "d": [], "t": []}, {"i": "EC:1.1.1.136", "l": "\"UDP-N-acetylglucosamine 6-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12735", "l": "5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate => CO2 + diphosphate + nicotinate beta-D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68997", "l": "2-oxoglutarate + gibberellin A9 + O2 => CO2 + gibberellin A4 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71983", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + fusoxypene B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001084", "l": "L-arabinofuranose binding", "d": ["Binding to L-arabinofuranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75874", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65792", "l": "fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682709", "l": "LGI4 binds ADAM22,23,11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22162", "l": "a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA => 4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.70", "l": "\"glucan 1,6-alpha-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825564", "l": "MESP2 binds the EPHA4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50846", "l": "(5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.169", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034923", "l": "phenanthrene-4,5-dicarboxylate decarboxylase activity", "d": ["Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74103", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371591", "l": "Trimerization of cytosolic HSF1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78845", "l": "a fatty acid(out) + ADP + H(+) + phosphate => a fatty acid(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42558", "l": "pseudouridine(2819) in 21S rRNA => uridine(2819) in 21S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41781", "l": "beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043886", "l": "structural constituent of carboxysome shell", "d": ["The action of a molecule that contributes to the structural integrity of a carboxysome shell, an organelle found in all cyanobacteria and some chemoautotrophs, consisting of a proteinaceous coat and enzymes for the fixation of CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73129", "l": "4',8-dihydroxy-7-methoxyflavone + S-adenosyl-L-homocysteine => 4',7,8-trihydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9680443", "l": "ROCK1,2 bind ROCKi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0005337", "l": "nucleoside transmembrane transporter activity", "d": ["Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69626", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030353", "l": "fibroblast growth factor receptor antagonist activity", "d": ["Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32884", "l": "(11R)-dihydroartemisinic aldehyde + NADP(+) => (+)-artemisinic aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25505", "l": "(2E)-geranyl diphosphate => beta-phellandrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389974", "l": "Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809140", "l": "IL35 binds IL-12RB2:IL6ST receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028583", "l": "Phosphorylation of YAP by LATS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38445", "l": "a wax ester + CoA => a fatty acyl-CoA + a long chain fatty alcohol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35040", "l": "spermidine(in) => spermidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877192", "l": "RUNX1 binds FOXP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40786", "l": "docosanoyl-CoA + H2O <=> CoA + docosanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786583", "l": "PUS7 transforms uridine to pseudouridine in tRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449087", "l": "CD4 binds Interleukin-16 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33324", "l": "a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.155", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507873", "l": "Aquaporins passively transport urea out of cells (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102115", "l": "peptidoglycan asparagine synthase activity", "d": ["Catalysis of the reaction: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + ammonium + ATP = H+ + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparaginyl)-L-lysyl-D-alanyl-D-alanine + AMP + diphosphoric acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050313", "l": "sulfur dioxygenase activity", "d": ["Catalysis of the reaction: S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57409", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) => 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801666", "l": "PLK2 phosphorylates CENPJ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13030", "l": "H2O + N-acetyl-D-glucosamine + O2 => H(+) + H2O2 + N-acetyl-D-glucosaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41279", "l": "H2O + N-octadecanoylsphing-4-enine = octadecanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976801", "l": "Complement factor I complex formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36842", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55831", "l": "cortisol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623999", "l": "BCL gene expression downstream of ESR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76787", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] = 1,10-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861595", "l": "Extension of pseudopodia by myosin-X in a PI3K dependent manner (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204958", "l": "NRAGE sequesters CHE1 in the cytoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77667", "l": "a globoside GalGb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a globoside GlcNAc-GalGb4Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19682", "l": "ATP + biotin + CoA => AMP + biotinyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11346", "l": "a CMP-N-acyl-beta-neuraminate + diphosphate => an N-acylneuraminate + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33726", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-tetracosanoylsphinganine <=> a 1,2-diacyl-sn-glycerol + N-tetracosanoylsphinganine-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70302", "l": "H2O + L-dehydroascorbate <=> 2,3-dioxo-L-gulonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044198", "l": "zf-TRAF domain binding", "d": ["Binding to a TRAF-type zinc finger domain of a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296045", "l": "Activation of Potassium transport channels (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54517", "l": "8-hydroxycopalyl diphosphate => (13R)-manoyl oxide + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612639", "l": "NRG2-activated ERBB4 binds GABA receptors through GABRA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163676", "l": "Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724685", "l": "IgE binds omalizumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617596", "l": "BAG6:GET4:UBL4A binds mislocalized membrane protein:SGTA and ASNA1:ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53572", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37964", "l": "galactitol + NAD(+) => D-galactose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694390", "l": "nsp15 binds RB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47632", "l": "H2O + L-arginine + NAD(+) = 5-guanidino-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913451", "l": "IL3RB is phosphorylated on Ser-585 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13713", "l": "a ubiquinone + succinate = a ubiquinol + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4411383", "l": "NLK phosphorylates TCF/LEF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160118", "l": "tRNA (guanine(7)-N2)-methyltransferase activity", "d": ["Catalysis of the reaction: guanosine(7) in tRNA + S-adenosyl-L-methionine = H+ + N(2)-methylguanosine(7) in tRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211206", "l": "Translocation of DFF to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004381", "l": "fucosylgalactoside 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23621", "l": "ATP + N(2)-(2-carboxyethyl)-L-arginine => AMP + deoxyamidinoproclavaminate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14552", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0016867", "l": "intramolecular acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group from one position to another within a single molecule."], "t": []}, {"i": "EC:5.4.1.-", "l": "\"Transferring acyl groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432426", "l": "CRY is activated by light and binds to cytosolic TIM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679205", "l": "ULK1 phosphorylates Beclin-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-213406", "l": "Disassociation of PLC-gamma1 from LAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27856", "l": "3-geranyl-4-hydroxybenzoate + diphosphate => (2E)-geranyl diphosphate + 4-hydroxybenzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.23", "l": "\"tyrosine ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28252", "l": "acetoacetyl-CoA + CO2 + CoA => acetyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080047", "l": "GDP-L-galactose phosphorylase activity", "d": ["Catalysis of the reaction: GDP-beta-L-galactose + phosphate = beta-L-galactose-1-phosphate + GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67541", "l": "(9Z)-hexadecenoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-hexadecenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211193", "l": "Homodimerization  of DFF40 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.31", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.19", "l": "\"taxifolin 8-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.9", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11058", "l": "4-aminophenol + CO2 + H2O + NADP(+) => 4-aminobenzoate + 2 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371353", "l": "Soluble TNF-α binds TNFR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5685319", "l": "CX3 complex formation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49347", "l": "2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682377", "l": "LC3 de-lipidation by ATG4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43317", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637796", "l": "Phosphorylation of SHC1 by p-5Y-EGFRvIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374899", "l": "Release of noradrenaline  at the synapse (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47559", "l": "H2O + taurodeoxycholate <=> deoxycholate + taurine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60204", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24305", "l": "glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] => CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20106", "l": "ADP + beta-D-fructose 6-phosphate => AMP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50589", "l": "13,14-dihydro-15-oxo-PGF2alpha + NADP(+) => 15-oxoprostaglandin F2alpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62137", "l": "dGMP + GTP => dGDP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008137", "l": "RUNX2 binds ZNF521 and HDAC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77835", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-glutamate + O2 = (2S)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]pentanedioate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63732", "l": "UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan O-beta-D-glucuronoside", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25527", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> 9alpha-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141207", "l": "peptide lactyltransferase (ATP-dependent) activity", "d": ["Catalysis of the reaction: lactate + ATP + L-lysyl-[protein] = N(6)-lactoyl-L-lysyl-[protein]+ AMP + diphosphate. Can also act on free lactate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58282", "l": "cyclic tetraadenylate + 4 diphosphate => 4 ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140850", "l": "histone H2B C-terminal K residue ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to a histone 2B at the conserved C-terminal lysine (K) residue. The last K residue is at position 119 in fission yeast, 123 in budding yeast, and 120 in mammals."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0016624", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide."], "t": []}, {"i": "EC:1.2.4.-", "l": "\"With a disulfide as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23136", "l": "a primary amine + S-adenosyl-L-methionine = a methylated primary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25948", "l": "a 1,2-diacyl-sn-glycerol + CTP = a 1,2-diacyl-sn-glycero-3-phosphate + CDP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.174", "l": "\"diacylglycerol kinase (CTP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63986", "l": "5-hydroxyuridine 5'-phosphate + ADP + H(+) => 5-hydroxyuridine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11743", "l": "2 glutathione + NADP(+) <=> glutathione disulfide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354173", "l": "Activation of Rap1 by cytosolic GEFs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947531", "l": "Molybdenum ion transfer onto molybdopterin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40780", "l": "2-aminopentanenitrile + H(+) + 2 H2O => L-2-aminopentanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451482", "l": "activated MEK2 binds ERK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17247", "l": "6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2 => 3-hydroxyanthranilate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437984", "l": "Phosphorylation of MKK3/MKK6 by activated TAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9816369", "l": "Expression of DUX4 in the zygote (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10323", "l": "trans-3-hydroxy-L-proline <=> 1-pyrroline-2-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75788", "l": "GTP(in) => GTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39102", "l": "3-oxodecanedioyl-CoA + CoA <=> acetyl-CoA + octanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36395", "l": "7-dehydrocholesterol + NADP(+) = 7-dehydrodesmosterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55041", "l": "(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48105", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14357", "l": "ATP + riboflavin = ADP + FMN + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.26", "l": "\"riboflavin kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54124", "l": "coelenterazine h dioxetanone = CO2 + excited coelenteramide h monoanion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033474", "l": "FGFR2b mutants bind an expanded range of ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332236", "l": "CBL neddylates TGFBR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68571", "l": "N(5)-hydroxy-L-ornithine <=> (3S)-1,2-diazinane-3-carboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34640", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 => H2O + NADP(+) + neopentalenolactone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64394", "l": "a dipeptide(in) + H(+)(in) => a dipeptide(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32045", "l": "2 ATP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247497", "l": "ERBB3 binds neuregulins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31119", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43363", "l": "an N-acylsphinganine + UDP-alpha-D-glucose <=> an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25213", "l": "H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine = 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689630", "l": "BAP1 binds BAP1-interacting complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68649", "l": "2 L-cysteine => H(+) + hydrogen sulfide + L-lanthionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12739", "l": "[PrdC protein]-L-selenocysteine/L-cysteine + D-proline => 5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474266", "l": "Formation of collagen fibrils (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43797", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198611", "l": "AKT phosphorylates IKKalpha (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679266", "l": "Beclin-1 complex translocates to the ER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1227964", "l": "ERBB2 homodimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41537", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine => 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71089", "l": "17beta-estradiol 3-sulfate(in) + 2 Na(+)(in) => 17beta-estradiol 3-sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72294", "l": "2,3-dimethylsuccinate(out) + 3 Na(+)(out) <=> 2,3-dimethylsuccinate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25810", "l": "3-aminopropanal + H2O2 + putrescine => H2O + O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37432", "l": "12,18-didecarboxysiroheme + 2 AH2 + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 A + 2 acetate + Fe-coproporphyrin III + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28815", "l": "4-hydroxybenzoate(in) + H(+)(out) = 4-hydroxybenzoate(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50673", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O => [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71468", "l": "H2O + substance P => L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33840", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) => 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68771", "l": "4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40844", "l": "FAD + H(+) + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964280", "l": "Active Gq binds BTK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804762", "l": "TP53 forms homotetramers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58277", "l": "6 ATP => cyclic hexaadenylate + 6 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34434", "l": "(+)-secoisolariciresinol + NADP(+) <=> (-)-lariciresinol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52390", "l": "4-O-phospho-D-threonate + ADP + H(+) => ATP + D-threonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192781", "l": "Viral mRNA Splicing (M, NS segments) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.44", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928639", "l": "p-EFNB binds GRB4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799350", "l": "Exocytosis of specific granule membrane proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693243", "l": "RHOD translocates to the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008790", "l": "arabinose isomerase activity", "d": ["Catalysis of the reaction: D-arabinose = D-ribulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835443", "l": "STAT1,STAT3 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73100", "l": "3'-dephospho-CoA(in) + AMP(out) => 3'-dephospho-CoA(out) + AMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770847", "l": "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54251", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9866253", "l": "apo-UQCRFS1 binds LYRM7 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56548", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174097", "l": "Association of Emi1 with Cdh1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682388", "l": "Autophagosome maturation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52003", "l": "a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + glutathione <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66465", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O => scalarane-17alpha-19-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78450", "l": "a globoside Gb3Cer (d18:1(4E)) + H2O <=> a fatty acid + a lysoGb3(d18:1(4E))", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392834", "l": "Activation of EPACs by cAMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50021", "l": "decanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944236", "l": "Association of procollagen type XIV (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9823939", "l": "IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080059", "l": "flavonol 3-O-arabinosyltransferase activity", "d": ["Catalysis of the reaction: UDP-arabinose + a flavonol = UDP + a flavonol 3-O-D-arabinoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468040", "l": "Cohesin binds PDS5 and WAPAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59011", "l": "H2O + O2 + salicylaldehyde <=> H(+) + H2O2 + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432143", "l": "PECAM-1 binds PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14625", "l": "[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) = [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)", "d": [], "t": []}, {"i": "EC:2.4.1.2", "l": "\"dextrin dextranase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35926", "l": "neamine + UDP-alpha-D-glucose <=> 3''-deamino-3''-hydroxykanamycin B + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433823", "l": "Released NFkB complex migrates to the nucleus and turns on transcription (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33102", "l": "acetyl-CoA + spermine <=> CoA + H(+) + N(1)-acetylspermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19261", "l": "ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate", "d": [], "t": []}, {"i": "EC:7.6.2.5", "l": "\"ABC-type heme transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013158", "l": "CDC42 GDIs block activation of CDC42 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16968", "l": "(2E)-geranyl diphosphate <=> beta-myrcene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22576", "l": "an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.81", "l": "\"quorum-quenching N-acyl-homoserine lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52038", "l": "L-isoleucine + tuberonate => H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21947", "l": "ATP + D-cellobiose <=> 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36887", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + AH2 + O2 = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050292", "l": "steroid 9-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3965450", "l": "DAAM1 recruits PFN1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052908", "l": "16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity", "d": ["Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47077", "l": "17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH => 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12376", "l": "ATP + L-fuculose = ADP + H(+) + L-fuculose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.51", "l": "\"L-fuculokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11548", "l": "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.54", "l": "\"acetoxybutynylbithiophene deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110506", "l": "Activated DTOR phosphorylates DS6K (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50384", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline = 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78741", "l": "3-oxooctadecanoyl-CoA + H(+) + NADH => (3S)-hydroxyoctadecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18272", "l": "ethyl (S)-3-hydroxyhexanoate + NADP(+) <=> ethyl 3-oxohexanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982778", "l": "Growth hormone binds the growth hormone receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78720", "l": "3-dehydro-alpha,alpha-trehalose + H2O => 3-dehydro-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39051", "l": "ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9656244", "l": "DRD2 binds DA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9861616", "l": "DLD dimer dehydrogenates dihydrolipoyl (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50344", "l": "3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH = 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.252", "l": "\"mycolipanoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38847", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29787", "l": "ATP + glutathione(in) + H2O = ADP + glutathione(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0140789", "l": "histone phosphatase activity", "d": ["Catalysis of the reaction: a phosphorylated histone + H2O = a protein + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72099", "l": "Na(+)(out) + O-acetyl-(R)-carnitine(out) = Na(+)(in) + O-acetyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19642", "l": "(E)-4-coumarate + ATP + CoA => (E)-4-coumaroyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62451", "l": "holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP <=> AMP + H(+) + L-glutamyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102245", "l": "lupan-3beta,20-diol synthase activity", "d": ["Catalysis of the reaction: lupan-3beta,20-diol = (S)-2,3-epoxysqualene + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20825", "l": "adenosine + ATP => ADP + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0150047", "l": "G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential", "d": ["G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1449574", "l": "SLC2A4 (GLUT4) vesicle fuses with the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733545", "l": "Bile salts and acids bind ALB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-445714", "l": "Aquaporin-3 passively transports water out of cell (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.56", "l": "\"gamma-humulene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75223", "l": "H2O + L-fucono-1,4-lactone = H(+) + L-fuconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42052", "l": "9-cis-retinol + NAD(+) = 9-cis-retinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210439", "l": "glutamate uptake by astrocytes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160906", "l": "20kDa HA fragments are translocated to lysosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59681", "l": "D-maltopentaose + O2 => D-maltopentaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683734", "l": "Glycosylated M localizes to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033934", "l": "glucan 1,4-alpha-maltotriohydrolase activity", "d": ["Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37233", "l": "L-alanine + NH4(+) => H2O + L-alaninamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70683", "l": "(R)-normetanephrine + S-adenosyl-L-methionine = (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11561", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) => catechol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63892", "l": "ATP + H2O + L-tryptophan = AMP + D-tryptophan + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78145", "l": "a 1,3-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61926", "l": "(2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate => (2S,4R)-ketoconazole(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32628", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9834821", "l": "p-PRKRA dimer binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39792", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950342", "l": "EBI3:CANX binds IL27 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2106614", "l": "Duplex miRNA is loaded into Argonaute (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10612", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.38", "l": "\"glycoprotein 2-beta-D-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480378", "l": "Expression of Goosecoid (GSC) in the primitive streak (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42984", "l": "(+)-copalyl diphosphate = diphosphate + pimara-8(14),15-diene", "d": [], "t": []}, {"i": "EC:4.2.3.147", "l": "\"pimaradiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034902", "l": "endosulfan sulfate hydrolase activity", "d": ["Catalysis of the reaction: endosulfan sulfate + H2O = endosulfan diol + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944246", "l": "Association of procollagen type XXI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299297", "l": "Activation of THIK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15500", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate <=> 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381612", "l": "GLP1R binds GLP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69299", "l": "CDT1 binds geminin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669023", "l": "TWEAK binds FN14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75856", "l": "9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] => 9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061513", "l": "glucose 6-phosphate:phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + phosphate(in) = glucose 6-phosphate(in) + phosphate(out)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938913", "l": "RUNX1 binds ELF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76508", "l": "(-)-2'-epi-GR24 + H2O => (-)-2'-epi-GR24 ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.7", "l": "\"asclepain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985343", "l": "RUNX2 binds SOX9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36658", "l": "desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine <=> descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070326", "l": "very-low-density lipoprotein particle receptor binding", "d": ["Binding to a very-low-density lipoprotein receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77132", "l": "1D-myo-inositol 1,2,6-trisphosphate + H2O => 1D-myo-inositol 1,2-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3857336", "l": "CEBPB homodimerization (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0004576", "l": "oligosaccharyl transferase activity", "d": ["Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021478", "l": "WWC1 (Kibra) gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40129", "l": "a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18333", "l": "ATP + oleandomycin = ADP + H(+) + oleandomycin 2'-O-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.136", "l": "\"macrolide 2'-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5444511", "l": "Formation of MSH2:MSH3 Complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57542", "l": "a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+) => a 5'-end NTP-ribonucleotide-RNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52541", "l": "cytidine + phosphate => alpha-D-ribose 1-phosphate + cytosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805122", "l": "AURKB binds TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57202", "l": "N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] => glyoxal + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37933", "l": "(10R)-hydroxy-(8S,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.73", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49549", "l": "H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] => H(+) + L-arginyl-[protein] + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51950", "l": "2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16991", "l": "1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73302", "l": "(S)-malate(out) + H(+)(in) + phosphate(in) <=> (S)-malate(in) + H(+)(out) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41839", "l": "H(+) + hexanoyl-[ACP] + malonyl-[ACP] <=> 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66778", "l": "ADP + H(+) + phosphate + uroporphyrin III(out) => ATP + H2O + uroporphyrin III(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45863", "l": "12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950398", "l": "CANX dissociates from IL27:EBI3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20973", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine => 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56536", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28331", "l": "H2O + ITP => H(+) + IDP + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41466", "l": "ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34268", "l": "acetyl-CoA + fumigaclavine B => CoA + fumigaclavine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29225", "l": "dihydroxyacetone phosphate + menaquinol-8 => menaquinone-8 + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16755", "l": "3,8-divinyl protochlorophyllide a + 2 H2O + NADP(+) => Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51792", "l": "H(+) + NADH + O2 + salicylate = 2,3-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23902", "l": "(1R,2R)-hydrobenzoin => cis-stilbene oxide + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37929", "l": "8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57297", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O => a 2'-deoxyguanosine in DNA + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19659", "l": "CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867047", "l": "PTPN3 dephosphorylates EPS15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35634", "l": "cyanidin + UDP-alpha-D-galactose <=> cyanidin 3-O-beta-D-galactoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12028", "l": "H2O + L-5-carboxymethylhydantoin = H(+) + N-carbamoyl-L-aspartate", "d": [], "t": []}, {"i": "EC:3.5.2.4", "l": "\"carboxymethylhydantoinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76833", "l": "H(+) + hexanal + NADH + NH4(+) => H2O + hexylamine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26426", "l": "ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.2", "l": "\"CTP synthase (glutamine hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730899", "l": "Oligomerization of BCL10 and MALT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211466", "l": "HNF1A-dependent synthesis of HNF4A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48582", "l": "[pyruvate, water dikinase] + diphosphate => [pyruvate, water dikinase]-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10060", "l": "acetyl-CoA + D-tryptophan = CoA + H(+) + N-acetyl-D-tryptophan", "d": [], "t": []}, {"i": "EC:2.3.1.34", "l": "\"D-tryptophan N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481009", "l": "Exocytosis of platelet dense granule content (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202702", "l": "CD177 binds PECAM-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72908", "l": "D-mannose(out) + Na(+)(out) => D-mannose(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004790", "l": "thioether S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78866", "l": "a short-chain (3R)-hydroxy fatty acyl-CoA <=> a short-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9015111", "l": "Factor Xa inhibitors binds Xa (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952996", "l": "E2F7 forms homodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987007", "l": "p-STAT1 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74199", "l": "aspulvinone E + O2 = (2Z)-2-[(3,4-dioxocyclohexa-1,5-dien-1-yl)methylidene]-4-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-olate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22262", "l": "H(+) + triacetate => H2O + triacetate lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190258", "l": "FGFR2c binds to FGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0005104", "l": "fibroblast growth factor receptor binding", "d": ["Binding to a fibroblast growth factor receptor (FGFR)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12417", "l": "beta-alanyl-CoA => acryloyl-CoA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78785", "l": "H(+) + isoorientin + UDP => luteolin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11569", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP => 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62140", "l": "dTMP + GTP = dTDP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24725", "l": "H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 <=> H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11354", "l": "acetyl phosphate + ADP => acetate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928591", "l": "EPH:EFN tetramers oligomerise (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30695", "l": "3-aminopropanal + H2O + NAD(+) = beta-alanine + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608866", "l": "VANGL2 is required for asymmetric membrane localization of FZD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340226", "l": "CYGB dioxygenates NO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694419", "l": "SARS-CoV-2 gRNA complement (minus strand):RTC binds RTC inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39215", "l": "(2E)-hexacosenoyl-CoA + H(+) + NADPH = hexacosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30970", "l": "9,9',15-tri-cis-zeta-carotene <=> 9,9'-di-cis-zeta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019914", "l": "cyclin-dependent protein kinase activating kinase regulator activity", "d": ["Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.143", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114354", "l": "SMAC binds XIAP:Caspase-7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77327", "l": "L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25364", "l": "3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+) => H(+) + momilactone A + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78387", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[SCAN] = L-cysteinyl-[SCAN] + S-nitroso-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295516", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28979", "l": "H(+)(out) + nitrite(in) = H(+)(in) + nitrite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75318", "l": "chloride(out) + D-serine(out) + 2 Na(+)(out) <=> chloride(in) + D-serine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11871", "l": "D-arabinitol + NADP(+) <=> D-ribulose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48771", "l": "ATP + D-erythrulose <=> ADP + D-erythrulose 4-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43042", "l": "CoA + H(+) + N-hexadecanoylhexadecasphinganine => hexadecanoyl-CoA + hexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874718", "l": "TTPA binds alpha-TOH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61606", "l": "[DsbA protein]-disulfide + [DsbB protein]-dithiol => [DsbA protein]-dithiol + [DsbB protein]-disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51350", "l": "10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine => acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24036", "l": "a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP", "d": [], "t": []}, {"i": "EC:2.7.4.4", "l": "\"nucleoside-phosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76221", "l": "GDP(out) => GDP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66208", "l": "(8R)-8-hydroxynonanoyl-CoA + O2 = (2E,8R)-8-hydroxynonenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65276", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64264", "l": "atrochrysone carboxylate + H(+) = atrochrysone + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012349", "l": "ME3 tetramer decarboxylates MAL to PYR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25612", "l": "beta-D-allofuranose <=> beta-D-allopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40803", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) = 3,6-anhydro-L-galactonate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9717841", "l": "holo-FDPS dimer binds NBPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1220612", "l": "Binding of EGF to ligand-responsive EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944216", "l": "Association of procollagen type XV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12900", "l": "2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31780", "l": "an all-trans-retinyl ester + H2O => 13-cis-retinol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21885", "l": "H2O + trithionate => H(+) + sulfate + thiosulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102599", "l": "cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity", "d": ["Catalysis of the reaction: beta-amyrin + O2 + H+ + NAD(P)H = 12,13beta-epoxy-beta-amyrin + H2O + NAD(P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730899", "l": "Oligomerization of BCL10 and MALT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72035", "l": "ATP(out) + 2 H(+)(out) + phosphate(in) = ATP(in) + 2 H(+)(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32163", "l": "ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine = AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": [], "t": []}, {"i": "EC:6.3.2.38", "l": "\"N(2)-citryl-N(6)-acetyl-N(6)-hydroxylysine synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047191", "l": "1-alkylglycerophosphocholine O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45784", "l": "2 H2O + phenylpropanonitrile = 3-phenylpropanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65289", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10241", "l": "a 2,3-saturated acyl-[ACP] + NAD(+) => a (2E)-enoyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21845", "l": "L-glutamine + phenylacetyl-CoA => CoA + H(+) + N(2)-phenylacetyl-L-glutamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60186", "l": "ADP + D-glucose(in) + H(+) + phosphate => ATP + D-glucose(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390425", "l": "FAR1 reduces PalmCoA to HXOL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11109", "l": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate => n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48682", "l": "a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH => a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70237", "l": "an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39290", "l": "Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine <=> dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160124", "l": "guanyl nucleotide exchange factor activator activity", "d": ["Binds to and increases the activity of a guanyl nucleotide exchange factor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28412", "l": "4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH => 4-(gamma-L-glutamylamino)butanal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27459", "l": "3,5-diiodo-L-tyrosine + H(+) + NADPH => 3-iodo-L-tyrosine + iodide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58106", "l": "(14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694373", "l": "Unphosphorylated nucleoprotein translocates to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.106", "l": "\"O-acetyl-ADP-ribose deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12528", "l": "N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate = [hyaluronan](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786114", "l": "IL13:IL13RA:TYK2 binds IL4R:JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11228", "l": "(2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.234", "l": "\"flavanone 4-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111883", "l": "Hydrolysis of phosphatidylcholine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10410", "l": "3-oxopristanoyl-CoA + CoA => 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22191", "l": "an (R)-2-haloacid + H2O <=> a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63097", "l": "ilicicolin A epoxide => ilicicolin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6790454", "l": "SUMOylation of XPC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69088", "l": "butanal + H2O + NAD(+) = butanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78336", "l": "ATP + UTP => 2',3'-cUAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.161", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17321", "l": "L-tryptophan + S-adenosyl-L-methionine = 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.106", "l": "\"tryptophan 2-C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467633", "l": "AGRN binds LRP4:MUSK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23164", "l": "a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose = a flavonol 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.237", "l": "\"flavonol 7-O-beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666001", "l": "Profilin:G-actin binds MKL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981892", "l": "Active G alpha (z) binds RGS proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49570", "l": "(3R)-3,4-epoxy-3-methylbut-1-ene + glutathione => 2-glutathionyl-2-methylbut-3-en-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018832", "l": "halohydrin hydrogen-halide-lyase B activity", "d": ["Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55934", "l": "AMP + H(+) + L-threonyl-[protein] => 3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:1901239", "l": "malonate(1-) transmembrane transporter activity", "d": ["Enables the transfer of malonate(1-) from one side of a membrane to the other."], "t": []}, {"i": "RHEA:33115", "l": "malonate(in) = malonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.60", "l": "\"glucan 1,4-alpha-maltotetraohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68819", "l": "(2Z,6E)-farnesyl diphosphate <=> (E)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10720", "l": "2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione", "d": [], "t": []}, {"i": "EC:1.5.4.1", "l": "\"pyrimidodiazepine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64478", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => 4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16506", "l": "chorismate => 4-hydroxybenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140835", "l": "RNA polymerase II CTD heptapeptide repeat T4 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphothreonine (position 4)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835496", "l": "TCF7L1 and CTNNB1 bind the GBX2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848586", "l": "Transport of cytosolic HXOL to the peroxisome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29112", "l": "H(+) + NADPH + ubiquinone-8 => NADP(+) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008977", "l": "prephenate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + prephenate = (4-hydroxyphenyl)pyruvate + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76835", "l": "ethylamine + H2O + NAD(+) = acetaldehyde + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.16", "l": "\"levan fructotransferase (DFA-IV-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46037", "l": "2'-deoxycytidine + UTP => dCMP + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20378", "l": "androsterone + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23708", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.4.99.28", "l": "\"peptidoglycan glycosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64254", "l": "CoA + H(+) + N-tetradecanoylglycine => glycine + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981610", "l": "Neuroglobin binds oxygen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64564", "l": "8-epi-ilicicolin H = ilicicolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62678", "l": "6-thio-IMP + 7,8-dihydrofolate + H2O => 10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24098", "l": "H(+) + isoscoparin + S-adenosyl-L-homocysteine => isoorientin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59847", "l": "(+)-dehydrodiconiferyl alcohol + H(+) + NADPH <=> (R)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41393", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849055", "l": "PTK6 binds ARHGAP35 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839053", "l": "AFG3L2:SPG7 binds SMDT1 (EMRE) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67120", "l": "N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50166", "l": "20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106388", "l": "18S rRNA aminocarboxypropyltransferase activity", "d": ["Catalysis of the reaction: N1-methylpseudouridine in 18S rRNA + S-adenosyl-L-methionine = H+ + N1-methyl-N3-[(3S)-3-amino-3-carboxypropyl]pseudouridine in 18S rRNA + S-methyl-5'-thioadenosine."], "t": []}, {"i": "RHEA:63296", "l": "an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.5.1.157", "l": "\"rRNA small subunit aminocarboxypropyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75876", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37850", "l": "13-dihydrodaunorubicin + H(+) + NADPH + O2 <=> daunorubicin + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69450", "l": "(-)-delta-cadinol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793887", "l": "TBX6 and LEF1:CTNNB1 bind the DLL1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35570", "l": "H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine <=> (9Z,12Z)-octadecadienoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832075", "l": "HNF1B binds the LFNG gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42160", "l": "(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 = (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008881", "l": "glutamate racemase activity", "d": ["Catalysis of the reaction: L-glutamate = D-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20829", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48025", "l": "1,2,3-tripropanoylglycerol + H2O => dipropanoylglycerol + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54822", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873923", "l": "STARD10 binds LPCAT1 and PC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61983", "l": "H(+) + NADPH + ubiquinone-10 <=> NADP(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70093", "l": "hydroxyclavatol ethyl ether => ethanol + o-quinone methide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252001", "l": "ATP1B4 binds SNW1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380311", "l": "Recruitment of Plk1 to centrosomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23121", "l": "a dipeptide(out) + ATP + H2O => a dipeptide(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23370", "l": "benzaldehyde + CO2 => H(+) + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035227", "l": "TXN2 binds CysS248-MPST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72520", "l": "2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate => 6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179421", "l": "Degradation of multiubiquitinated Nek2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63151", "l": "H2O + N-(9Z-octadecenoyl)-taurine <=> (9Z)-octadecenoate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68070", "l": "a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336443", "l": "LIN7, CASK and APBA1 bind (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683663", "l": "N-glycan trimming of Spike (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23571", "l": "(2E)-decenoyl-[ACP] <=> (3Z)-decenoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19565", "l": "(2E)-geranyl diphosphate + H2O = diphosphate + sabinene hydrate", "d": [], "t": []}, {"i": "EC:4.2.3.11", "l": "\"sabinene-hydrate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168459", "l": "Lyn activates ERK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30404", "l": "Fe(3+)(out) + L-ascorbate(in) => Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45000", "l": "(R)-carnitine + 3-hydroxybutanoyl-CoA = CoA + O-3-hydroxybutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102272", "l": "homophytochelatin synthase activity (polymer-forming)", "d": ["Catalysis of the reaction: glutathionate + a poly gamma-glutamylcysteine-beta-alanine = glycine + a poly gamma-glutamylcysteine-beta-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013145", "l": "RAC1 binds effectors at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22068", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726949", "l": "PTGIR binds PTGIR agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011595", "l": "GSTZ1 dimer dehalogenates DCA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78479", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624033", "l": "Initiation of HCMV DNA Replication (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63290", "l": "9-hydroperoxy-(5Z,7E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21397", "l": "(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) => CO2 + Na(+)(out) + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48770", "l": "ADP + D-erythrulose 4-phosphate + H(+) => ATP + D-erythrulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75353", "l": "4-oxo-4-(pyridin-3-yl)butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) + methylamine => 2 Fe(III)-[cytochrome c] + H2O + pseudooxynicotine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12851", "l": "L-seryl-[myosin light chain] + phosphate => H2O + O-phospho-L-seryl-[myosin light chain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950183", "l": "IL12B binds IL23A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729437", "l": "SARS-CoV-2 N binds to TRIM25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981637", "l": "Complement factor I inactivates C4BP-bound C4b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141316", "l": "TRAIL:TRAIL-Receptor2 Trimer:FADD complex binds procaspase-10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14117", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O = [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate", "d": [], "t": []}, {"i": "EC:3.2.1.67", "l": "\"galacturonan 1,4-alpha-galacturonidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25870", "l": "3-acetamidopropanal + H2O2 + N(1)-acetylspermidine => H2O + N(1),N(12)-diacetylspermine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30929", "l": "5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose => 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20890", "l": "3-hydroxy-2-methylpropanoate + CoA + H(+) => 3-hydroxy-2-methylpropanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014467", "l": "RHOG binds effectors at the ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61371", "l": "4-methylumbelliferone sulfate(in) + ATP + H2O <=> 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78175", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol = a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32969", "l": "a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55445", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] => cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12040", "l": "(S)-3-(imidazol-5-yl)lactate + NADP(+) = 3-(imidazol-5-yl)pyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62570", "l": "glycine + S-benzyl-L-cysteine => H2O + S-benzyl-L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49383", "l": "5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683801", "l": "CHEK2 phosphorylates BRCA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76940", "l": "2-methylpropan-1-amine + H2O + NADP(+) => 2-methylpropanal + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42688", "l": "AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide = A + ergothioneine + NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:4.4.1.36", "l": "\"hercynylcysteine S-oxide lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45269", "l": "4'-hydroxyechinenone + AH2 + O2 => 4',4'-dihydroxyechinenone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804379", "l": "PRMT5 binds TTC5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66688", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 = (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167917", "l": "SMAD7 binds to SMURF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252001", "l": "ATP1B4 binds SNW1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805811", "l": "Release of SEPT4 from mitochondria (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0042974", "l": "nuclear retinoic acid receptor binding", "d": ["Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11191", "l": "3-cyano-L-alanine + 2 H2O <=> L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796074", "l": "NFE2L2 dependent ABCC1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0042056", "l": "chemoattractant activity", "d": ["Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28968", "l": "L-proline(in) + Na(+)(in) => L-proline(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63645", "l": "GDP-beta-L-fucose + L-seryl-[protein] => 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71105", "l": "L-methionine(out) + S-methylmercury-L-cysteine(in) => L-methionine(in) + S-methylmercury-L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74822", "l": "glutathione(in) <=> glutathione(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76416", "l": "Benzene is hydroxylated to phenol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814088", "l": "SYS1 binds AcM-ARFRP1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12623", "l": "CO2 + L-alanine => H(+) + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754763", "l": "SARS-CoV-2 M protein binds TUFM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63848", "l": "2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 = 2 3',4'-dihydroxyaurone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534388", "l": "Progesterone Activation Of CatSper (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72253", "l": "(R)-metanephrine + H(+) + S-adenosyl-L-homocysteine => (R)-adrenaline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42159", "l": "androsterone + H(+) + NADPH <=> 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48949", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73851", "l": "27-hydroxywithanone + UDP-alpha-D-glucose = H(+) + UDP + withanone 27-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17240", "l": "ATP + FMN + H(+) <=> diphosphate + FAD", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443779", "l": "Linkage of L1 with treadmilling F-actin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36513", "l": "(11Z)-3-oxoicosenoyl-CoA + CO2 + CoA => (9Z)-octadecenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62746", "l": "(S)-2-methylbutanoate + compactin diol lactone + H(+) => H2O + mevastatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033831", "l": "kojibiose phosphorylase activity", "d": ["Catalysis of the reaction: kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19413", "l": "ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)", "d": [], "t": []}, {"i": "EC:6.1.1.20", "l": "\"phenylalanine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51684", "l": "(2E,6E)-farnesyl phosphate + CTP = (2E,6E)-farnesyl diphosphate + CDP", "d": [], "t": []}, {"i": "EC:2.7.4.32", "l": "\"farnesyl phosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430096", "l": "GP1b-IX-V binds filamin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28402", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29867", "l": "AMP + ITP = ADP + IDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29194", "l": "L-aspartate + menaquinone-8 <=> iminosuccinate + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17891", "l": "acetaldehyde + NH4(+) + phosphate => H2O + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734730", "l": "ORC1 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69903", "l": "cytidine(out) + 2 Na(+)(out) = cytidine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32361", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+) => 1D-myo-inositol 1,4,5-trisphosphate + 2 ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876255", "l": "CBL recruits CIN85:endophilin complex to InlB-bound MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73609", "l": "CTP(in) + dCTP(out) => CTP(out) + dCTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0016737", "l": "oxidoreductase activity, acting on reduced flavodoxin as donor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.19.-.-", "l": "\"Acting on reduced flavodoxin as donor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9854961", "l": "SDHAF4 binds to FAD-SDHA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879930", "l": "STAT5 is recruited by JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68144", "l": "ethyl 3-oxobutanoate + H(+) + NADPH = ethyl (R)-3-hydroxybutanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77081", "l": "Formation of the CE:GMP intermediate complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75321", "l": "chloride(in) + D-alanine(in) + 2 Na(+)(in) => chloride(out) + D-alanine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380782", "l": "STAT binds to the active receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.5", "l": "\"cucurbitacin Delta(23)-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25479", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-himachalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004173", "l": "ecdysone O-acyltransferase activity", "d": ["Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78339", "l": "2',3'-cGAMP + H2O = 5'-pGpA(2'-5') + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45022", "l": "H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine => L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052678", "l": "levopimaradiene synthase activity", "d": ["Catalysis of the reaction: (+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58456", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + D-mannose", "d": [], "t": []}, {"i": "EC:3.2.1.170", "l": "\"mannosylglycerate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64762", "l": "ethanethiol + NH4(+) + pyruvate => H2O + S-ethyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46811", "l": "[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine <=> [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685607", "l": "Sialic acid binds SIGLEC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64351", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) <=> deacetylpyripyropene E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61053", "l": "(-)-vincadifformine + O2 + reduced [NADPH--hemoprotein reductase] => (-)-minovincinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11337", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine => deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16418", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) => H(+) + L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46057", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39731", "l": "3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352927", "l": "dihydroxyacetone phosphate <=> glyceraldehyde 3-phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37050", "l": "H(+)(out) + L-histidine(out) <=> H(+)(in) + L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093331", "l": "Ras:GTP binds p120-RasGAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15988", "l": "formate + NAD(+) <=> CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450088", "l": "GLUT1 tetramer binds 4xATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41888", "l": "3-oxotetradecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5221061", "l": "TDG excises 5-carboxylcytosine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0042805", "l": "actinin binding", "d": ["Binding to actinin, any member of a family of proteins that crosslink F-actin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043818", "l": "precorrin-3B synthase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + precorrin-3A = H2O + NAD+ + precorrin-3B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205306", "l": "Interaction of SHP1 and KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.32", "l": "\"brachyurin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9633044", "l": "ESR binds STRN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67483", "l": "2-oxoglutarate + O2 + prekainate <=> CO2 + H2O + kainate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389842", "l": "HAO1 tetramer oxidizes glycolate to glyoxylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79112", "l": "cholate + L-arginine => H2O + L-arginocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.9", "l": "\"(R)-2-haloacid dehalogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12361", "l": "(2E)-2-methylbut-2-enoyl-CoA + 13-hydroxylupanine => 13-(2-methylcrotonoyloxy)lupanine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189069", "l": "sucrose + H2O => glucose + fructose (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68773", "l": "(2Z,6Z)-farnesyl diphosphate => diphosphate + germacrene C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935730", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102843", "l": "1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity (SN2-16:1 forming)", "d": ["Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14247", "l": "AMP + diphosphate + H(+) => ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9866217", "l": "HCCS inserts heme into cytochrome c (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940032", "l": "TWIST1 binds the RUNX2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093342", "l": "SDC2 multimerises (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74598", "l": "(2S,3R)-3-methyl-L-aspartate <=> mesaconate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55627", "l": "an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O <=> 3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004034", "l": "aldose 1-epimerase activity", "d": ["Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003874", "l": "6-pyruvoyltetrahydropterin synthase activity", "d": ["Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H+ + triphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30463", "l": "(2Z,6Z)-farnesyl diphosphate = (+)-alpha-santalene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.50", "l": "\"(+)-alpha-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507873", "l": "Aquaporins passively transport urea out of cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354087", "l": "Recruitment of GRB2 to p-PTK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37993", "l": "beta-tocopherol + H(+) + S-adenosyl-L-homocysteine => delta-tocopherol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.745825357329565", "identifiers": [{"i": "GO:0008236", "l": "serine-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28297", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-(E)-beta-caryophyllene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76463", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + A = 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171122", "l": "LDL + LDLR => LDL:LDLR complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38849", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35360", "l": "3-hydroxyisoheptadecanoyl-CoA => (2E)-15-methylhexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28496", "l": "a menaquinol + dimethyl sulfoxide => a menaquinone + dimethyl sulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821931", "l": "BOD1L1 binds SET1A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2752115", "l": "SPP1 (osteopontin) binds CD44 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15998", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADH + O2 => 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730843", "l": "Phosphorylation of LAT by p-SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212222", "l": "PRC2 recruits DNA methyltransferases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662710", "l": "IL6 gene produces IL6 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681294", "l": "IL6R binds IL6R inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031516", "l": "far-red light photoreceptor activity", "d": ["The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873850", "l": "STARD5 binds DCA, LCA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036121", "l": "double-stranded DNA helicase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433410", "l": "SOCS1 as a regulator of KIT signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047105", "l": "4-trimethylammoniobutyraldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9845308", "l": "DNMT3A:DNMT3L in nascent RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L methylates cytosine in DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16052", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole <=> adenosylcob(III)alamin + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34779", "l": "a 3alpha-hydroxysteroid + NAD(+) = a 3-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52963", "l": "hyocholate + UDP-alpha-D-glucuronate <=> hyocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58848", "l": "(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-hydroxygeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019770", "l": "IgG receptor activity", "d": ["Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468040", "l": "Cohesin binds PDS5 and WAPAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62744", "l": "H2O + mevastatin = (S)-2-methylbutanoate + compactin diol lactone + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70188", "l": "alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose => cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26164", "l": "AH2 + echinenone + O2 = 4'-hydroxyechinenone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42369", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55219", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + rhizathalene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483186", "l": "PC is converted to PS by PTDSS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382058", "l": "Nck binds to the active PDGF receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671772", "l": "p-T38-PPP1R14A binds MLCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23839", "l": "D-methionine + pyruvate <=> 4-methylsulfanyl-2-oxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63196", "l": "(10bR,4aS)-noroxomaritidine + H(+) + NADPH = (10bR,4aS)-oxomaritidine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833820", "l": "PKR dimer autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018817", "l": "2-oxo-hept-3-ene-1,7-dioate hydratase activity", "d": ["Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76360", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) => n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9716913", "l": "ESR1 binds ESR1 antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58967", "l": "H2O + hexanal + O2 <=> H(+) + H2O2 + hexanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33506", "l": "ATP + H2O + itraconazole(in) <=> ADP + H(+) + itraconazole(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67595", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O <=> (R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64545", "l": "acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine => 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23035", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65988", "l": "previtamin D3 = calciol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165195", "l": "GTP loading by Rheb (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41175", "l": "Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+) = methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine", "d": [], "t": []}, {"i": "EC:2.1.1.249", "l": "\"[dimethylamine--corrinoid protein] Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022734", "l": "MECP2 binds FKBP5 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013021", "l": "GDIs block activation of RHOB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16095", "l": "(24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65019", "l": "chlorothalonil + H2O <=> 4-hydroxychlorothalonil + chloride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31621", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10725", "l": "GDP-6-deoxy-alpha-D-talose + NADP(+) => GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73181", "l": "H(+) + S-adenosyl-L-homocysteine + scutellarein 4'-methyl ether => S-adenosyl-L-methionine + scutellarein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417820", "l": "P2Y9 receptor can bind to LPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29384", "l": "dIMP + H2O => 2'-deoxyinosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447030", "l": "NrCAM binds Ankyrin-G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.45", "l": "\"E1 ubiquitin-activating enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49227", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31846", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA <=> 2-oxepin-2(3H)-ylideneacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30576", "l": "3 menaquinone-8 + protoporphyrinogen IX => 3 menaquinol-8 + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265936", "l": "Phosphorylation of RPA2 by CDC2 kinase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17490", "l": "H(+) + NADH + O2 + phthalate => cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29095", "l": "5 H(+)(in) + NADH + ubiquinone-8 = 4 H(+)(out) + NAD(+) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139918", "l": "Phosphorylation of BIM by JNK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30258", "l": "2 a ubiquinol + O2 <=> 2 a ubiquinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640167", "l": "RRAGA,B exchanges GDP for GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9853385", "l": "PPP1CC dephosphorylates PLK1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634834", "l": "ACHEIs bind ACHE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17869", "l": "5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35816", "l": "4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) => 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696323", "l": "CNRs bind CNR agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21520", "l": "2 Fe(III)-[cytochrome b1] + formate = CO2 + 2 Fe(II)-[cytochrome b1] + H(+)", "d": [], "t": []}, {"i": "EC:1.2.2.1", "l": "\"formate dehydrogenase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.65", "l": "\"macrophage elastase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199093", "l": "CXADR binds to AMICA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21970", "l": "3-dehydroquinate + phosphate => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050069", "l": "lysine dehydrogenase activity", "d": ["Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45338", "l": "[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA => (9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74710", "l": "fumagillol + NADP(+) <=> 5-dehydrofumagillol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75863", "l": "all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45171", "l": "2 (E)-sinapoyl-CoA + spermidine <=> 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697084", "l": "Defective rpoB in Mtb RNAP transcribes RNA polyanion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33350", "l": "2-iminoacetate + H2O <=> glyoxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77666", "l": "1-O-alkyl-3-acylglycerol + an acyl-CoA <=> 1-O-alkyl-2,3-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34448", "l": "dTDP-6-deoxy-beta-L-talose + NAD(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11073", "l": "anthranilate + 3 H(+) + NADPH + O2 => catechol + CO2 + NADP(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130194", "l": "ABL phosphorylates WAVEs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.80", "l": "\"acetylajmaline esterase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25746", "l": "H(+) + N,N-dihydroxy-L-pentahomomethionine <=> (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26463", "l": "6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine => 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23732", "l": "(R)-5-diphosphomevalonate + ATP = ADP + CO2 + isopentenyl diphosphate + phosphate", "d": [], "t": []}, {"i": "EC:4.1.1.33", "l": "\"diphosphomevalonate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14158", "l": "H2O + triphosphate => diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18363", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+) => a dolichyl D-xylosyl phosphate + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443831", "l": "14-3-3-zeta binds Raf1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52278", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate => (6S)-5,6,7,8-tetrahydrofolate + vanillate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43929", "l": "pregn-5-ene-3,20-dione => progesterone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.37", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102164", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone synthase activity", "d": ["Catalysis of the reaction: 2-heptyl-4-quinolone + NADH + O2 + H+ = 2-heptyl-3-hydroxy-4-quinolone + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24843", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30874", "l": "2-deoxy-D-ribose + ATP <=> 2-deoxy-D-ribose 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21453", "l": "a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 => a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10702", "l": "limonene-1,2-diol => H2O + limonene 1,2-epoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61154", "l": "CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => (E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418172", "l": "F2R binds ARRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42482", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+) => 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254251", "l": "ERBB4s80 binds YAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77514", "l": "2-methoxybenzaldehyde + hydrogen cyanide <=> (2S)-2-hydroxy-2-(2-methoxyphenyl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44943", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O <=> 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38257", "l": "(S)-malyl-CoA + succinate => (S)-malate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30894", "l": "O-acetyl-L-serine + thiosulfate <=> acetate + H(+) + S-sulfo-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877153", "l": "STARD7 binds PC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793837", "l": "TBX6 binds the MESP2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16273", "l": "an N-acylsphing-4-enine + CDP-choline = a sphingomyelin + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.3", "l": "\"ceramide cholinephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44286", "l": "4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + 2 malonyl-CoA + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51408", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62597", "l": "(S)-8-oxocitronellyl enol + NAD(+) => (6E)-8-oxogeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54018", "l": "(8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61306", "l": "H(+) + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP => N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54684", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (-)-kolavenyl diphosphate", "d": [], "t": []}, {"i": "EC:5.5.1.28", "l": "\"(-)-kolavenyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54036", "l": "[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) = [mycoredoxin]-S-mycothiol-L-cysteine + arsenite", "d": [], "t": []}, {"i": "EC:1.20.4.3", "l": "\"mycoredoxin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012087", "l": "Autocatalytic phosphorylation of FGFR4 Y367C mutant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39719", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate = 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38767", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980125", "l": "ITCH binds DTX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78294", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> (R,2E)-alpha-cericerene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0030368", "l": "interleukin-17 receptor activity", "d": ["Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48029", "l": "H2O + triacetin => acetate + diacetylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74838", "l": "UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-galactosamine(in) <=> UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-galactosamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73311", "l": "L-thyroxine sulfate(out) = L-thyroxine sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13783", "l": "a 2-oxocarboxylate + H2O2 + NH4(+) => an L-alpha-amino acid + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042299", "l": "lupeol synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16866", "l": "choloyl-CoA + propanoyl-CoA => 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67094", "l": "ADP + docosanoate(out) + H(+) + phosphate => ATP + docosanoate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163310", "l": "TFAM binds to mitochondrial promoters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912386", "l": "Ubiquitination of NOTCH1 by ITCH in the absence of ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22888", "l": "(R)-methylmalonyl-CoA = succinyl-CoA", "d": [], "t": []}, {"i": "EC:5.4.99.2", "l": "\"methylmalonyl-CoA mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70613", "l": "GOT2 transaminates OA and L-Glu (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1470010", "l": "Dimerization of STATs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202245", "l": "Phosphorylation of TBSMs in LAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295632", "l": "PPA2A dephosphorylates SPRY2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871226", "l": "RET binds GFRA1,GFRA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170156", "l": "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64748", "l": "H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine = 2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58217", "l": "A + dihydroserpentine => AH2 + serpentine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77303", "l": "N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44227", "l": "16-hydroxyhexadecanoate + ATP + CoA <=> 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30845", "l": "formate + H(+) + maleamate => H2O + N-formylmaleamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63238", "l": "6-O-adenylylstreptomycin + diphosphate => ATP + streptomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53396", "l": "a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51912", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8850945", "l": "Casein kinase II phosphorylates PTEN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203567", "l": "palmitoylation of eNOS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936963", "l": "IRAK2 induces TRAF6 oligomerization (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047366", "l": "quercetin-3-sulfate 4'-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H+ + quercetin 3,4'-disulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74742", "l": "Phosphorylation of SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15596", "l": "amicoumacin A 2-phosphate + H2O <=> amicoumacin A + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.10", "l": "\"oligo-1,6-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13493", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428625", "l": "Vesicular inhibitory amino acid transport (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12231", "l": "ATP + H2O + L-aspartate + L-glutamine <=> AMP + diphosphate + H(+) + L-asparagine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694737", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.3.7", "l": "\"tetrahydrocannabinolic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20435", "l": "D-xylulose + H(+) + NADH => NAD(+) + xylitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034046", "l": "poly(G) binding", "d": ["Binding to a sequence of guanine residues in an RNA molecule."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14540", "l": "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H(+) + H2O <=> 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696465", "l": "USP45 deubiquitinates ERCC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008271", "l": "CITED1 and EP300 bind ESR1:estrogen:TGFA gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762343", "l": "PREDL:ALB dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23324", "l": "2'-phospho-[ligated tRNA] + NAD(+) = ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide", "d": [], "t": []}, {"i": "EC:2.7.1.160", "l": "\"2'-phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12070", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[ACP] => apo-[ACP] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41835", "l": "(2E)-hexenoyl-[ACP] + H(+) + NADPH <=> hexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47421", "l": "A + glutaryl-CoA => (2E)-glutaconyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41455", "l": "5-methyl-1-naphthoate + H(+) + NADPH + O2 <=> 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.222", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63798", "l": "C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate => C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331331", "l": "TP53 binds the PMAIP1 (NOXA) promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24984", "l": "(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9853369", "l": "PLK1 phosphorylates FIRMM at S744 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77808", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-valine + O2 => 2-dehydro-D-glucose + H2O2 + L-valine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69835", "l": "campesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112342", "l": "Inactivation of MAP2K1 by CDK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24365", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) => 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170978", "l": "p-FRS2:CRKL binds C3G (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66712", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69687", "l": "genistein 7-O-beta-D-glucoside + H2O = beta-D-glucose + genistein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396399", "l": "Fibrillins bind BMPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53701", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66828", "l": "2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18399", "l": "AMP + diphosphate + L-glutamyl-tRNA(Glx) => ATP + L-glutamate + tRNA(Glx)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72464", "l": "L-threonyl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29080", "l": "(R)-lactate + ubiquinone-8 => pyruvate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72697", "l": "Start codon recognition (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8934742", "l": "RUNX1 binds PRMT1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70952", "l": "D-serine + H2O + O2 => 3-hydroxypyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36536", "l": "docosanoyl-CoA + sphinganine => CoA + H(+) + N-docosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627089", "l": "CASP9 is phosphorylated at T412 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177942", "l": "EGFR binds EGF ligand (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72290", "l": "2,2-dimethylsuccinate(out) + 3 Na(+)(out) <=> 2,2-dimethylsuccinate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814387", "l": "CASP14 cleaves filaggrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32006", "l": "(+)-copalyl diphosphate <=> diphosphate + isopimara-8(14),15-diene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614460", "l": "Dimerization of procollagen type VI (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052846", "l": "inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity", "d": ["Catalysis of the reaction: 1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48101", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75225", "l": "H(+) + L-fuconate => H2O + L-fucono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.28", "l": "\"phenylsuccinyl-CoA transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46841", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016297", "l": "fatty acyl-[ACP] hydrolase activity", "d": ["Catalysis of the reaction: a fatty acyl-[ACP] + H2O = a fatty acid + H+ + holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30175", "l": "15-cis-phytoene + 2 plastoquinone-9 = 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39705", "l": "(13Z)-eicosenoyl-CoA + NADP(+) => (2E,13Z)-eicosadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388831", "l": "Phosphorylation of CD28 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74063", "l": "2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60560", "l": "L-methionyl-[protein] + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56921", "l": "a medium chain fatty acid + ATP + H(+) => a medium-chain fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28926", "l": "H(+)(in) + L-phenylalanine(in) <=> H(+)(out) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416929", "l": "PTGFR binds PGF2a (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69858", "l": "a 5,6-dihydrouridine in mRNA + NADP(+) <=> a uridine in mRNA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50383", "l": "3 H(+) + 3 malonyl-CoA <=> 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8934446", "l": "Activated PKC phosphorylates SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70175", "l": "beta-D-glucosyl-(1->4)-D-galactose + phosphate = alpha-D-glucose 1-phosphate + D-galactose", "d": [], "t": []}, {"i": "EC:2.4.1.388", "l": "\"glucosylgalactose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57397", "l": "(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine => 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63335", "l": "alpha-L-arabinopyanose <=> beta-L-arabinopyranose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102209", "l": "trans-permethrin hydrolase activity", "d": ["Catalysis of the reaction: (-)-trans-permethrin + H2O = H+ + (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710263", "l": "GZMB cleaves GSDME (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21981", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) => adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77848", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-tyrosine + O2 => (2S)-3-(4-hydroxyphenyl)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029158", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.10", "l": "\"non-chaperonin molecular chaperone ATPase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64332", "l": "ATP + CoA + nicotinate = AMP + diphosphate + nicotinyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43238", "l": "1,2-dihexadecanoyl-sn-glycerol + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59791", "l": "H2O + NAD(+) + pseudopaline <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9639286", "l": "RRAGC,D exchanges GTP for GDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381128", "l": "Translation of ATF4  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76267", "l": "carnosine(in) = carnosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76779", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] = 1,6-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035990", "l": "Defective HLCS does not biotinylate 6x(PCCA:PCCB) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73054", "l": "hydrogencarbonate(in) + taurocholate(out) <=> hydrogencarbonate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445705", "l": "Release Of ADP From Myosin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29724", "l": "glyoxylate(in) => glyoxylate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0008270", "l": "zinc ion binding", "d": ["Binding to a zinc ion (Zn)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404135", "l": "RBP4 binds atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25495", "l": "(2E)-geranyl diphosphate <=> (-)-beta-phellandrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65360", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-purine ribonucleoside in mRNA + H2O = a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63170", "l": "S-(2-succino)-L-cysteine => fumarate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76856", "l": "2-aminopentane + H2O + NAD(+) => H(+) + NADH + NH4(+) + pentan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380949", "l": "AMPK is dephosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42336", "l": "[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.8.7.2", "l": "\"ferredoxin:thioredoxin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157629", "l": "NOTCH2-ligand complex is cleaved to produce NEXT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11000", "l": "an N-carbamoyl-D-amino acid + 2 H(+) + H2O = a D-alpha-amino acid + CO2 + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.77", "l": "\"N-carbamoyl-D-amino-acid hydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71562", "l": "5-N(alpha)-glycyl-dTMP in DNA + A + H2O <=> 5-aminomethyl-dUMP in DNA + AH2 + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912503", "l": "Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35102", "l": "fusidate(in) + H(+)(out) <=> fusidate(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201603", "l": "Caspase-mediated cleavage of PKC theta (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70198", "l": "ATP + deamido-NAD(+) <=> ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57556", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22432", "l": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.35", "l": "\"3-hydroxyacyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76808", "l": "(S)-isoleucinol + H2O + NAD(+) => (3S)-1-hydroxy-3-methylpentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12799", "l": "CO2 + H(+) + H2O + scopolamine + succinate => (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209823", "l": "Tyrosine is hydroxylated to dopa (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54571", "l": "a uridine in rRNA <=> a pseudouridine in rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65751", "l": "2-oxoglutarate + dodecyl sulfate + O2 <=> CO2 + dodecanal + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54242", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5603467", "l": "Activated protein C is released from PROCR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76871", "l": "(S)-1-phenylethylamine + H2O + NAD(+) = acetophenone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36656", "l": "desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine => descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73064", "l": "H(+)(out) + Mn(2+)(in) => H(+)(in) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34116", "l": "carboxynorspermidine + H2O + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24460", "l": "H(+) + malonyl-[ACP] = acetyl-[ACP] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34912", "l": "D-methionine(in) => D-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36923", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109860", "l": "MAP2K1 phosphorylates MAPK3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67269", "l": "(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate => sch 210972", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70648", "l": "D-serine(out) + H(+)(out) => D-serine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806629", "l": "Formation of tonofilament bundles (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47252", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703435", "l": "FLT3 fusions activate STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839401", "l": "TGFBR3 degradation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140819", "l": "UDP-beta-L-arabinofuranose transporter activity", "d": ["Enables the transfer of UDP-beta-L-arabinofuranose from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67609", "l": "H2O + N(6)-methyl-ATP => diphosphate + H(+) + N(6)-methyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71688", "l": "glycyl-L-aspartate(out) + 2 H(+)(out) => glycyl-L-aspartate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29791", "l": "ATP + glutathione(out) + H2O = ADP + glutathione(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.4.2.10", "l": "\"ABC-type glutathione transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373732", "l": "Nephrin trans-homophilic interaction (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033938", "l": "1,6-alpha-L-fucosidase activity", "d": ["Catalysis of the hydrolysis of (1->6) linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48325", "l": "a ganglioside GD1b + GDP-beta-L-fucose => a ganglioside Fuc-GD1b + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047461", "l": "(+)-delta-cadinene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (+)-delta-cadinene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28938", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate <=> oxaloacetate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019797", "l": "procollagen-proline 3-dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44629", "l": "L-dihydroanticapsin + NAD(+) => H(+) + L-anticapsin + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389350", "l": "Activation of Cdc42 by pVav1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014294", "l": "RAC2 binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483087", "l": "PI is exchanged with PC by PITPNB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6790454", "l": "SUMOylation of XPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11456", "l": "N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.101", "l": "\"alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000774", "l": "adenyl-nucleotide exchange factor activity", "d": ["Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins."], "t": []}, {"i": "REACT:R-HSA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61069", "l": "acetyl-CoA + horhammericine => 19-O-acetylhorhammericine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62216", "l": "isoepoxydon + NADP(+) = H(+) + NADPH + phyllostine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16154", "l": "a primary methyl amine + H2O + O2 => an aldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12182", "l": "H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine => anthranilate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174967", "l": "NAT2 acetylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019160", "l": "NMN nucleosidase activity", "d": ["Catalysis of the reaction: H2O + nicotinamide mononucleotide = D-ribose 5-phosphate + H+ + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50773", "l": "H2O + nitroethane + O2 => acetaldehyde + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54255", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015190", "l": "L-leucine transmembrane transporter activity", "d": ["Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798004", "l": "TP53 stimulates BNIP3L expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10080", "l": "dihydrophloroglucinol + NADP(+) = 1,3,5-trihydroxybenzene + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.57", "l": "\"phloroglucinol reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681294", "l": "IL6R binds IL6R inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39410", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71841", "l": "dehydroepiandrosterone 3-sulfate(in) => dehydroepiandrosterone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836275", "l": "TFAP2A binds TFAP2B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15694", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 => (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626681", "l": "Recruitment of transition zone proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68595", "l": "ORC2 binds ORC3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76250", "l": "ATP + ergothioneine(out) + H2O <=> ADP + ergothioneine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2512800", "l": "SCARB1:ligand is endocytosed (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17453", "l": "5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.13", "l": "\"phosphoribosylamine--glycine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15620", "l": "Fe(3+) + Fe(II)-[cytochrome c] <=> Fe(2+) + Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102243", "l": "ATP:geranylgeraniol phosphotransferase activity", "d": ["Catalysis of the reaction: (E,E)-geranylgeraniol + ATP = H+ + all-trans-geranyl-geranyl monophosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681514", "l": "TMPRSS2 binds TMPRSS2 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52782", "l": "2-sulfenohercynine + NH4(+) + pyruvate => H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30354", "l": "H(+) + NADH + O2 + pyrrole-2-carboxylate <=> 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31559", "l": "L-galactose + NAD(+) = H(+) + L-galactono-1,4-lactone + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.316", "l": "\"L-galactose 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047720", "l": "indoleacetaldoxime dehydratase activity", "d": ["Catalysis of the reaction: (indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050077", "l": "maleylpyruvate isomerase activity", "d": ["Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21408", "l": "H2O + L-phenylalanine + NAD(+) = 3-phenylpyruvate + H(+) + NADH + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.1.20", "l": "\"phenylalanine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15636", "l": "3,4-dihydroxyphenylacetate + O2 <=> 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035560", "l": "pheophorbidase activity", "d": ["Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42020", "l": "11-dehydrocorticosterone + NAD(+) = H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963915", "l": "1,25(OH)2D binds VDR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062082", "l": "HLA-E specific inhibitory MHC class Ib receptor activity", "d": ["Combining with a MHC class Ib molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111883", "l": "Hydrolysis of phosphatidylcholine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34249", "l": "1-deoxymethyl-3-dehydrosphinganine + H(+) + NADPH => 1-deoxymethyl-sphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863718", "l": "AGFG1 binds VAMP7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23841", "l": "3-(2,3-dihydroxyphenyl)propanoate + O2 => (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52958", "l": "hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP => hyodeoxycholate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033608", "l": "formyl-CoA transferase activity", "d": ["Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62260", "l": "2 hydrogencarbonate(out) + Mn(2+)(out) = 2 hydrogencarbonate(in) + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69209", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168884", "l": "Hemagglutinin (HA) protein synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683888", "l": "LMCD1 binds GATA6, sequestering it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56713", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] => H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702508", "l": "FLT mutants bind type I TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691421", "l": "BTK binds BTK inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29195", "l": "(S)-dihydroorotate + a menaquinone = a menaquinol + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73109", "l": "apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine => acacetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69891", "l": "Na(+)(out) + thymidine(out) = Na(+)(in) + thymidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218847", "l": "PAK2 binds NCK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19088", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44077", "l": "ATP + CoA + pentadecanoate => AMP + diphosphate + pentadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10749", "l": "H(+) + hydrogencarbonate => CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046979", "l": "TAP2 binding", "d": ["Binding to the TAP2 subunit of TAP (transporter associated with antigen processing) protein."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043995", "l": "histone H4K5 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.29", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30676", "l": "tetrahymanol => H2O + squalene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033296", "l": "rhamnose binding", "d": ["Binding to the D- or L-enantiomer of rhamnose."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72014", "l": "glutathione(in) + urate(out) <=> glutathione(out) + urate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454916", "l": "The ABCC family mediates organic anion transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811427", "l": "COPI vesicle uncoating at the ER (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17138", "l": "prostaglandin H2 => thromboxane A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38818", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670436", "l": "p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37363", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 = 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651789", "l": "LIG1 bound to POLB ligates SSB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170846", "l": "TGFBR2 recruits TGFBR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60778", "l": "CO2 + gibberellin A15 + succinate => 2-oxoglutarate + gibberellin A12 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54030", "l": "a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34282", "l": "di-trans,poly-cis-dolichol + NADP(+) <=> di-trans,cis-polyprenol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27589", "l": "L-tryptophan + pyruvate <=> indole-3-pyruvate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32186", "l": "cholesterol + O2 <=> cholest-5-en-3-one + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10467", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O <=> n acetate + chitosan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20050", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O => 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701064", "l": "TRPV1 binds TRPV1 agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65906", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine => 3-hydroxy-L-kynurenine + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380586", "l": "loading of Serotonin in synaptic vesicles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59133", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP => AMP + diphosphate + H(+) + staphyloferrin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13584", "l": "N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47812", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13961", "l": "ATP + H2O + Mg(2+) + protoporphyrin IX = ADP + 3 H(+) + Mg-protoporphyrin IX + phosphate", "d": [], "t": []}, {"i": "EC:6.6.1.1", "l": "\"magnesium chelatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69587", "l": "GMP + inosine <=> guanosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033404", "l": "UUG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUG codon."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695964", "l": "ABHD14B hydrolyses PNPB (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70575", "l": "3',5'-cyclic UMP + H2O = H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53340", "l": "5,6-dihydrouridine(20) in tRNA + NAD(+) = H(+) + NADH + uridine(20) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39718", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 <=> (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69644", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 => (2E,5Z,8Z,11Z,14Z,17Z)-icosahexaenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14176", "l": "dimethylallyl diphosphate + L-tryptophan <=> 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73908", "l": "4-hydroxy-N,N,N-trimethyltryptamine + ATP => ADP + aeruginascin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610879", "l": "GluN1 (GRIN1) binds to NEFL at postsynaptic density (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67178", "l": "H(+) + methanol + O13(4)-desmethyl pFDCC => H2O + primary fluorescent dioxobilin-type chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1236970", "l": "Proteasomal clevage of exogenous antigen (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204779", "l": "Interaction of Tie2 with Ang1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9824986", "l": "XPO1-dependent export of p-S69,S73 MITF-M (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63226", "l": "2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50804", "l": "glutathione + prostaglandin J2 = prostaglandin J2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18415", "l": "a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351207", "l": "Spermine  => N-acetylated spermine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50351", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] <=> a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791223", "l": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.203", "l": "\"carboxymethylcellulase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57622", "l": "H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase] => dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.98", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299338", "l": "Activation of TRESK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666008", "l": "SCAI binds SRF:MKL1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66864", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + quiannulatene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23842", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+) => 3-(2,3-dihydroxyphenyl)propanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22684", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 = (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.65", "l": "\"4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174097", "l": "Association of Emi1 with Cdh1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37256", "l": "A + D-asparagine + H2O => 2-oxosuccinamate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050519", "l": "holo-citrate lyase synthase activity", "d": ["Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45089", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35915", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322135", "l": "Defective MMAA does not protect MUT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78477", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39211", "l": "(3R)-hydroxyhexacosanoyl-CoA = (2E)-hexacosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66735", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) <=> ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21510", "l": "H(+) + hexadecanoate + retinol => all-trans-retinyl hexadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41714", "l": "a 2-acyl-sn-glycerol 3-phosphate + choline + H(+) => a 2-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21201", "l": "2-oxoglutarate + L-lysine => (S)-2-amino-6-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26561", "l": "(3S)-3-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37728", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21410", "l": "3-phenylpyruvate + H(+) + NADH + NH4(+) => H2O + L-phenylalanine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49433", "l": "cholate + lithocholoyl-CoA => choloyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56794", "l": "2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196857", "l": "PANK2 phosphorylates PanK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51072", "l": "a phenol + an aryl sulfate = a phenol + an aryl sulfate", "d": [], "t": []}, {"i": "EC:2.8.2.22", "l": "\"aryl-sulfate sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.6", "l": "\"exodeoxyribonuclease VII\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034546", "l": "2,4-dichloroaniline reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2,4-dichloroaniline + 2 H+ + 2 e- = 4-chloroaniline + HCl."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39529", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+) => (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77314", "l": "glyoxylate + N(omega),N(omega)-dimethyl-L-arginine <=> 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25629", "l": "myricetin + S-adenosyl-L-methionine = H(+) + laricitrin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36804", "l": "2-hydroxy-2,3-dihydrogenistein => genistein + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018852", "l": "dichloromuconate cycloisomerase activity", "d": ["Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19334", "l": "H(+) + oxalyl-CoA => CO2 + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052819", "l": "heteroglycan 2-alpha-mannosyltransferase activity", "d": ["Catalysis of the reaction: heteroglycan + GDP-mannose = (1->2)-alpha-D-mannosylheteroglycan + GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11506", "l": "H(+) + S-adenosyl-L-homocysteine + sterigmatocystin => 6-demethylsterigmatocystin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74496", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B => yaequinolone C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024586", "l": "AT-RvD1-6 translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10222", "l": "AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr) => ATP + L-tyrosine + tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63363", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052915", "l": "23S rRNA (guanine(2445)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23S rRNA = N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62786", "l": "bifonsecin B + 2 H2O + NADP(+) => 2 fonsecin B + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15166", "l": "H2O + O2 + sarcosine => glyoxylate + H2O2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75563", "l": "cyathadiol + O2 + reduced [NADPH--hemoprotein reductase] = cyathatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694442", "l": "CNIH2,3 bind GRIA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36769", "l": "CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine => 2-hydroxytetracosenoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28362", "l": "dGTP + H2O = dGMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73090", "l": "AMP(out) + FAD(in) <=> AMP(in) + FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947535", "l": "Cyclisation of GTP to precursor Z (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67372", "l": "H2O + L-seryl-L-threonine = L-serine + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247497", "l": "ERBB3 binds neuregulins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42826", "l": "H2O + 2 NAD(+) + tetracenomycin C => 2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2214324", "l": "Collagen type VII dimerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25333", "l": "(R)-carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55394", "l": "an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.31", "l": "\"[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23079", "l": "4-chlorobenzoyl-CoA + chloride + NADP(+) <=> 2,4-dichlorobenzoyl-CoA + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69958", "l": "Ca(2+)(in) + 3 Na(+)(out) <=> Ca(2+)(out) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174070", "l": "Association of Cdh1 with the APC/C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685605", "l": "SLAMF7 binds SLAMF7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62237", "l": "a cytidine(6-4)cytidine in DNA => a cytidine dimer in DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64965", "l": "dUTP + 2 H2O => dUMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42436", "l": "L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein] = L-ascorbate 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.194", "l": "\"protein-N(pi)-phosphohistidine--L-ascorbate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109514", "l": "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77629", "l": "1-O-alkyl-3-acylglycerol + CoA => 1-O-alkylglycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798743", "l": "Exocytosis of secretory granule membrane proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77091", "l": "ATP + isochorismate + L-glutamate = AMP + diphosphate + H(+) + isochorismoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20496", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine <=> an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20027", "l": "gibberellin A3 O-beta-D-glucoside + H(+) + UDP => gibberellin A3 + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676177", "l": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61871", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42265", "l": "H(+) + malonyl-[ACP] + octanoyl-CoA => 3-oxodecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8951644", "l": "Release of mature NEDD8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53351", "l": "5,6-dihydrouridine(20a) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20a) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37503", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37572", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28294", "l": "(2E,6E)-farnesyl diphosphate = (-)-(E)-beta-caryophyllene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.57", "l": "\"(-)-beta-caryophyllene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32788", "l": "ATP + H2O + L-ectoine(out) => ADP + H(+) + L-ectoine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9861640", "l": "CTLH E3 ligase ubiquitinates PKM-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14281", "l": "2 Fe(III)-[cytochrome c] + H2O + sulfite = 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfate", "d": [], "t": []}, {"i": "EC:1.8.2.1", "l": "\"sulfite dehydrogenase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16383", "l": "H(+) + L-xylulose + NADH => L-arabinitol + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70124", "l": "3-dehydro-6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 6-dehydro-28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45065", "l": "H2O + N-hexadecanoylethanolamine => ethanolamine + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60842", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein] => a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60674", "l": "H(+) + NADH + neral => NAD(+) + nerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35152", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) => (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77077", "l": "Capping complex formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74615", "l": "PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24403", "l": "ATP + UMP <=> ADP + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10206", "l": "formaldehyde + methylamine + reduced [electron-transfer flavoprotein] => dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.99", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877421", "l": "CTLA4 gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420724", "l": "CASR binds Ca2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15921", "l": "2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}, {"i": "EC:2.4.1.184", "l": "\"galactolipid galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865107", "l": "MICAL1 produces NADP+, H2O2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28056", "l": "formate + propanoyl-CoA => 2-oxobutanoate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34333", "l": "(indol-3-yl)acetate + CO2 + H2O + NADP(+) => H(+) + indole-3-pyruvate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73718", "l": "ATP(in) + dATP(out) <=> ATP(out) + dATP(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446322", "l": "PARVA associates with Paxillin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15931", "l": "CO2 + N-(hydroxymethyl)urea + 2 NH4(+) => 2 H(+) + 2 H2O + methylenediurea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31566", "l": "H2O + leukotriene C4 <=> L-glutamate + leukotriene D4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690449", "l": "S1PR1 bind S1P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.78", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29976", "l": "2'-deoxycytidine(in) + H(+)(in) => 2'-deoxycytidine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34987", "l": "(S)-lactate(in) = (S)-lactate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000340", "l": "RNA 7-methylguanosine cap binding", "d": ["Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.6", "l": "\"endo-1,3(4)-beta-glucanase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64153", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707683", "l": "PGRMC2 binds Hemes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35296", "l": "adenylyl-molybdopterin + H(+) + tungstate => AMP + H2O + W-molybdopterin cofactor", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010490", "l": "UDP-4-keto-rhamnose-4-keto-reductase activity", "d": ["Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH = UDP-rhamnose + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008261", "l": "allatostatin receptor activity", "d": ["Combining with allatostatin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45454", "l": "ethanolamine + tetradecanoate => H2O + N-tetradecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858940", "l": "MITF-M-dependent ATP6V0B gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8963864", "l": "CUBN dissociates from 25(OH)D (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23092", "l": "H(+) + H2O + hydroxyatrazine = ethylamine + N-isopropylammelide", "d": [], "t": []}, {"i": "EC:3.5.4.43", "l": "\"hydroxydechloroatrazine ethylaminohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59282", "l": "D-asparagine => L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66961", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose => beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37677", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873921", "l": "Binding of STAT1 to p-IFNGR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54603", "l": "2-oxoglutarate + O2 + octanoyl-CoA <=> 2-hydroxyoctanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33114", "l": "(2E,6E)-farnesyl diphosphate <=> beta-copaene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638006", "l": "ARL3 hydrolyzes GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102515", "l": "pelargonidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose = pelargonidin 3,7-di-O-beta-D-glucoside + ferulate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009485", "l": "IL34:CSF1 binds CSF1R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26016", "l": "3-dehydroquinate => 3,7-dideoxy-D-threo-hepto-2,6-diuolosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35574", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] <=> (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36004", "l": "(S)-4-hydroxy-2-oxohexanoate => propanal + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73486", "l": "D-lysine(in) + L-ornithine(out) <=> D-lysine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48881", "l": "a quinone + CO + H2O => a quinol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047696", "l": "beta-adrenergic receptor kinase activity", "d": ["Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964773", "l": "OXGR1 binds 2OG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450348", "l": "Activated human JNKs migrate to nucleoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65690", "l": "a diacylglycerol + an N-(38-(9Z,12Z-octadecadienoyloxy)-octatriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(38-hydroxyoctatriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45599", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74743", "l": "kaempferol + S-adenosyl-L-methionine = 3-O-methylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23335", "l": "(2R)-3-phosphoglycerate + GTP <=> (2R)-3-phospho-glyceroyl phosphate + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25454", "l": "diphosphate + germacrene A => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37231", "l": "H2O + L-alaninamide = L-alanine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42692", "l": "[(1->4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1->4)-alpha-D-glucosyl](n+2) + phosphate", "d": [], "t": []}, {"i": "EC:2.4.99.16", "l": "\"starch synthase (maltosyl-transferring)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44392", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14952", "l": "A + H2O + quinoline-4-carboxylate <=> 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047075", "l": "2,5-dihydroxypyridine 5,6-dioxygenase activity", "d": ["Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75998", "l": "3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) <=> 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68552", "l": "NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine = H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029468", "l": "Conversion of PA into DAG by PAP-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51771", "l": "2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate <=> 4-prenylphlormethylbutanophenone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54594", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17259", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine => O2 + reduced [NADPH--hemoprotein reductase] + vinorine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.7", "l": "\"cholate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44324", "l": "1-butyrylglycerol + H2O = butanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.54", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333051", "l": "RPA1 binds HSF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70612", "l": "L-lysyl-[protein] + tetradecanoyl-[ACP] => H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13703", "l": "CoA + O-acetyl-L-homoserine => acetyl-CoA + L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071933", "l": "Arp2/3 complex binding", "d": ["Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60848", "l": "a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033726", "l": "aldehyde ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17439", "l": "(2E,4E)-2,4-dichloromuconate + H(+) => 2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836404", "l": "p-PKR dimer phosphorylates MAPT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77533", "l": "(2S)-2-hydroxydecanenitrile => hydrogen cyanide + nonanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49138", "l": "H2O + L-methionyl-S-oxide-[protein] + NADP(+) => H(+) + L-methionyl-[protein] + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017129", "l": "triglyceride binding", "d": ["Binding to a triester of glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768950", "l": "NPAS4 binds FOS gene enhancer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59743", "l": "L-cysteinyl-[protein] + octadecanoyl-CoA <=> CoA + S-octadecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111962", "l": "PDE4A,C,D hydrolyse cAMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400204", "l": "PPARA binds RXRA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174255", "l": "Degradation multiubiquitinated Cyclin A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021450", "l": "PLXND1 gene expression is stimulated by NOTCH1,NOTCH3 coactivator complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24355", "l": "ethyl (R)-3-hydroxyhexanoate + NADP(+) <=> ethyl 3-oxohexanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39128", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42283", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75801", "l": "Na(+)(in) + pyruvate(in) => Na(+)(out) + pyruvate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15308", "l": "betaine aldehyde + H2O + NAD(+) <=> glycine betaine + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59985", "l": "an N(2)-acyl-L-glutamine + H2O => a carboxylate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58817", "l": "ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20904", "l": "(S)-2-hydroxypropyl-coenzyme M = (S)-1,2-epoxypropane + coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5660666", "l": "CBP and p300 binds NF-kB complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74555", "l": "(S)-malate(out) = (S)-malate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218822", "l": "CRK binds BCAR1 and or PXN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57811", "l": "1-chloro-3-nitrobenzene + NADH + O2 <=> 3-chlorocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43104", "l": "AH2 + an N-acyleicosasphinganine + O2 = A + an N-acyleicosasphing-4-enine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52936", "l": "3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O = (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39466", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA <=> (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50816", "l": "androst-4-ene-3,17-dione + H(+) + NADPH = 5alpha-androstan-3,17-dione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832168", "l": "NS2 (1B) forms a homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244506", "l": "botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59453", "l": "a long-chain primary fatty alcohol + NADP(+) => a long-chain fatty aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791076", "l": "Expression of ADD1 (Adducin alpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41823", "l": "butanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39758", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73219", "l": "L-xylopyranose(out) + 2 Na(+)(out) = L-xylopyranose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674529", "l": "AAMP binds to TBXA2R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59820", "l": "2 ATP = adenosine 3'-diphosphate,5'-triphosphate + AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71601", "l": "2-oxoglutarate(in) + maleate(out) => 2-oxoglutarate(out) + maleate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39790", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32704", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => 8-hydroxycopalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26253", "l": "H(+) + isopimara-7,15-dienol + NADPH + O2 = 2 H2O + isopimara-7,15-dienal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37737", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043856", "l": "anti-sigma factor antagonist activity", "d": ["The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47243", "l": "H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70968", "l": "3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) => 3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52530", "l": "2-oxosuccinamate + L-glutamate => 2-oxoglutarate + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050055", "l": "limonin-D-ring-lactonase activity", "d": ["Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15155", "l": "4-(beta-D-glucosyloxy)benzoate + H(+) + UDP => 4-hydroxybenzoate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70241", "l": "an N-acylsphing-4-enine + cholesteryl 3-beta-D-xyloside => a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50045", "l": "an acyl-CoA + H2O => adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865994", "l": "GAB1 binds PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852010", "l": "BTNL2 binds activated T cells surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15101", "l": "H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine", "d": [], "t": []}, {"i": "EC:4.1.1.20", "l": "\"diaminopimelate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73429", "l": "H2O + oxidized [NADPH--hemoprotein reductase] + scutellarein 7-methyl ether => genkwanin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853405", "l": "TPX2 binds AURKA at centrosomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610722", "l": "CK1 phosphorylates p-GLI3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61890", "l": "diosgenin 3-O-beta-D-glucoside + H(+) + UDP => diosgenin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23387", "l": "D-cellobiose <=> beta-D-glucosyl-(1->4)-D-mannopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15824", "l": "2 A + glycine <=> 2 AH2 + CO2 + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22726", "l": "a sterol 3-beta-D-glucoside + H(+) + UDP => a sterol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63692", "l": "alcohol glucuronate acceptor + UDP-alpha-D-glucuronate = a beta-D-glucuronoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080031", "l": "methyl salicylate esterase activity", "d": ["Catalysis of the reaction: methyl salicylate + H2O = salicylic acid + methanol + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78591", "l": "(3S)-hydroxyeicosanoyl-CoA = (2E)-eicosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53214", "l": "17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15132", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] <=> (1S,6R)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050258", "l": "riboflavinase activity", "d": ["Catalysis of the reaction: H2O + H+ + riboflavin = D-ribitol + lumichrome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52424", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59699", "l": "D-cellotetraono-1,5-lactone + H2O <=> D-cellotetraonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19435", "l": "6-phospho-D-gluconate + ADP + H(+) => ATP + D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43408", "l": "sphinganine + UDP-alpha-D-galactose = beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70875", "l": "L-glutamine(in) + L-methionine(out) + Na(+)(out) = L-glutamine(out) + L-methionine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70363", "l": "cyanurate + H2O = 1-carboxybiuret + H(+)", "d": [], "t": []}, {"i": "EC:3.5.2.15", "l": "\"cyanuric acid amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203070", "l": "Association of profilin with monomeric actin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33830", "l": "ergosterol <=> vitamin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008741", "l": "ribulokinase activity", "d": ["Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67110", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65038", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55058", "l": "a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66362", "l": "(3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+) => (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033966", "l": "N-substituted formamide deformylase activity", "d": ["Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211224", "l": "Association of DFF40 with DFF45 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45941", "l": "12-methyloctadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-methyl-2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719448", "l": "PIAS1 SUMOylates THRB with SUMO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17766", "l": "(2R)-3-phospho-glyceroyl phosphate => (2R)-2,3-bisphosphoglycerate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130504", "l": "Cleavage of lip22 to lip10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31872", "l": "(S)-2,3-epoxysqualene => alpha-seco-amyrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9853385", "l": "PPP1CC dephosphorylates PLK1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034871", "l": "1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity", "d": ["Catalysis of the reaction: 1-hydroxy-4,4-dimethylpentan-3-one = 4,4-dimethyl-3-oxopentanal + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29085", "l": "oxaloacetate + ubiquinol-8 => (S)-malate + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28065", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate <=> alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420274", "l": "GIP receptor binds gastric inhibitory peptide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681294", "l": "IL6R binds IL6R inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797100", "l": "CCNK binds CDK13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871494", "l": "SORL1 binds APP(18-770) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38947", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008054", "l": "IL1F10 binds IL1RAPL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419087", "l": "LIM kinase phosphorylation by ROCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26199", "l": "ammeline + NH4(+) => H2O + melamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033856", "l": "pyridoxine 5'-phosphate synthase activity", "d": ["Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H2O + H+ + phosphate + pyridoxine 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52377", "l": "(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42685", "l": "gamma-L-glutamyl-hercynylcysteine S-oxide + H2O => L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28664", "l": "H2O + melibiose => D-galactose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0030614", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide."], "t": []}, {"i": "EC:1.20.4.-", "l": "\"With disulfide as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209536", "l": "IkB is ubiquitinated and degraded (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327746", "l": "FN1 aggregation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983266", "l": "Kinesins bind microtubules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018529", "l": "nitrilotriacetate monooxygenase activity", "d": ["Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688786", "l": "ATXN3 binds RAD23 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55313", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43369", "l": "dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72072", "l": "L-histidyl-[protein] + NAD(+) => H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870469", "l": "RGGT geranylgeranylates RAB proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69874", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65373", "l": "a globoside GalGb4Cer + CMP-N-acetyl-beta-neuraminate => a globoside MSGG + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202222", "l": "Phosphorylation of PKC theta (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32141", "l": "AMP + diphosphate + malonyl-CoA => ATP + CoA + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392263", "l": "AVP(20-28) binds AVPR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19139", "l": "6beta-hydroxyestradiol-17beta + A + H2O => 17beta-estradiol + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167014", "l": "pro-beta-NGF homodimer transits to the golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15488", "l": "(2R,3S)-homoisocitrate <=> cis-homoaconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74910", "l": "(2E)-but-2-enoyl-AMP + holo-[ACP] <=> (2E)-butenoyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627078", "l": "XIAP binds CASP9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0004585", "l": "ornithine carbamoyltransferase activity", "d": ["Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14589", "l": "luteolin + S-adenosyl-L-methionine = chrysoeriol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20246", "l": "ATP + streptomycin => 3''-O-adenylylstreptomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14398", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) => (4Z)-2-oxohept-4-enedioate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74615", "l": "UDP-alpha-D-galactose(in) + UDP-alpha-D-glucose(out) = UDP-alpha-D-galactose(out) + UDP-alpha-D-glucose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.36", "l": "\"sn-1 acyl-lipid omega-3 desaturase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56489", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901611", "l": "phosphatidylglycerol binding", "d": ["Binding to phosphatidylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72595", "l": "H(+)(out) + N-acetyl-L-aspartyl-L-glutamate(out) = H(+)(in) + N-acetyl-L-aspartyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39498", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43328", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35501", "l": "glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74789", "l": "L-histidyl-L-proline diketopiperazine(out) => L-histidyl-L-proline diketopiperazine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851058", "l": "AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77144", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.18", "l": "\"GDP-mannose 3,5-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67930", "l": "a 3'-end 3'-phosphouridine-RNA + H(+) => a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186773", "l": "PDGF dimer binds two receptors simultaneously (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11633", "l": "AH2 + L-selenocysteine => A + H(+) + hydrogenselenide + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832908", "l": "ZNF521 binds the SOX1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936583", "l": "APS is phosphorylated to PAPS (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20035", "l": "penicillin N => isopenicillin N", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17745", "l": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.90", "l": "\"N-acetyllactosamine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373732", "l": "Nephrin trans-homophilic interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46682", "l": "2 Fe(II)-[cytochrome b5] + H(+) + NAD(+) => 2 Fe(III)-[cytochrome b5] + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15324", "l": "(6aR,11aR)-3,9-dihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2465940", "l": "atRAL is reduced to atROL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65073", "l": "(2E,6E)-farnesyl diphosphate => dauca-4,7-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76777", "l": "1,7-decanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => decan-1-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16232", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) <=> a CDP-1,2-diacyl-sn-glycerol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033936", "l": "polymannuronate hydrolase activity", "d": ["Catalysis of the endohydrolysis of the D-mannuronide linkages of polymannuronate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.18", "l": "\"1,4-alpha-glucan branching enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.71", "l": "\"pancreatic elastase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64760", "l": "H2O + S-ethyl-L-cysteine = ethanethiol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58021", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => eupatolide + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47702", "l": "H2O + iso-precytochalasin + NADP(+) => H(+) + ketocytochalasin + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21307", "l": "ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48977", "l": "5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 => CO2 + H2O + NAD(+) + pyocyanin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46110", "l": "(2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+) => (2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592278", "l": "Autocatalytic activation of proMMP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21568", "l": "beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O = beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose", "d": [], "t": []}, {"i": "EC:3.2.1.140", "l": "\"lacto-N-biosidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29427", "l": "(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) = (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56531", "l": "chloride + D-tryptophan + FADH2 + O2 <=> 6-chloro-D-tryptophan + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15024", "l": "(E)-feruloyl-CoA + L-quinate <=> 4-O-feruloyl-D-quinate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847880", "l": "CYTH proteins bind ARF1:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693644", "l": "HOXB1 maintains activation of HOXB1 chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75687", "l": "ATP(in) = ATP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592235", "l": "Expression of POLG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701556", "l": "IL2RG gene expression downstream of ALK signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655262", "l": "Activated FGFR3 point, translocation and fusion mutants bind FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351341", "l": "Exocytosis of Proactivator polypeptide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60237", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 => 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799332", "l": "ATR phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004060", "l": "arylamine N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2529020", "l": "CK2 phosphorylates condensin I subunits (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42023", "l": "11-dehydrocorticosterone + NAD(+) <=> H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3204303", "l": "MRE11 binds cytosolic DNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30044", "l": "fumarate + L-aspartate => iminosuccinate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380586", "l": "loading of Serotonin in synaptic vesicles (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44284", "l": "2 H(+) + 2 malonyl-CoA + octanoyl-CoA = 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42500", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701534", "l": "p-Y705, S727 STAT3 dimer binds HIF1A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43448", "l": "H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.62", "l": "\"multiple inositol-polyphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76503", "l": "4-O-beta-D-glucosyl-trans-ferulate + H2O = 4-O-beta-D-glucosyl-vanillin + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60774", "l": "3 CO2 + gibberellin A9 + 2 H2O + 2 succinate => 2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32948", "l": "a 2-acylglycerol + an acyl-CoA => a 1,2-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430308", "l": "PARVB interacts with Alpha-actinin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38472", "l": "L-histidine + 3 S-adenosyl-L-methionine => 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018756", "l": "ammeline aminohydrolase activity", "d": ["Catalysis of the reaction: ammeline + H2O = ammelide + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14601", "l": "L-lysine + O2 = 5-aminopentanamide + CO2 + H2O", "d": [], "t": []}, {"i": "EC:1.13.12.2", "l": "\"lysine 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34159", "l": "acetyl-CoA + UDP-N-acetylbacillosamine = CoA + H(+) + UDP-N,N'-diacetylbacillosamine", "d": [], "t": []}, {"i": "EC:2.3.1.203", "l": "\"UDP-N-acetylbacillosamine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51899", "l": "H2O + N(1)-acetylspermine <=> acetate + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071771", "l": "aldehyde oxygenase (deformylating) activity", "d": ["Catalysis of the reaction: a long-chain fatty aldehyde + H+ + 2 NADPH + O2 = a long-chain alkane + formate + H2O + 2 NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69330", "l": "5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur => (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66883", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66866", "l": "diphosphate + quiannulatene => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047558", "l": "3-cyanoalanine hydratase activity", "d": ["Catalysis of the reaction: L-asparagine = 3-cyano-L-alanine + H2O + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65698", "l": "a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689085", "l": "ATXN3 binds polyUb-PARK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744887", "l": "Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0004058", "l": "aromatic-L-amino-acid decarboxylase activity", "d": ["Catalysis of the reaction: L-amino acid + H+ = R-H + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158357", "l": "factor XIIa binds SERPING1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75862", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51336", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46064", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51231", "l": "17alpha-ethynylestradiol + 3'-phosphoadenylyl sulfate <=> 17alpha-ethynylestradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16487", "l": "1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16460", "l": "(2R,3S)-tartrate + NAD(+) <=> 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162253", "l": "PDSS1,2 ligates FPP to IPPP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41155", "l": "1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74009", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + diphosphate => dimethylallyl diphosphate + H2O + yaequinolone E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53849", "l": "NAD(+) + taurocholate => 7-oxo-taurodeoxycholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34948", "l": "(Z)-3-aminoacrylate + H(+) + H2O => 3-oxopropanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682388", "l": "Autophagosome maturation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16514", "l": "(S)-lactate + O2 => acetate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008782", "l": "adenosylhomocysteine nucleosidase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937856", "l": "p-Y-YAP1 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187575", "l": "Ubiquitination of phospho-p27/p21 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.26", "l": "\"peptide-tryptophan 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018814", "l": "RHOT1 hydrolyzes GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9855910", "l": "USF1 is phosphorylated by p-MAPK14 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004822", "l": "isoleucine-tRNA ligase activity", "d": ["Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23218", "l": "3-hydroxybenzoyl-CoA + H2O + NADP(+) => benzoyl-CoA + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76899", "l": "cyclohexylamine + H2O + NADP(+) = cyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31761", "l": "dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26193", "l": "(S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate", "d": [], "t": []}, {"i": "EC:6.2.1.9", "l": "\"malate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33119", "l": "(2E,6E)-farnesyl diphosphate = (+)-sativene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.129", "l": "\"(+)-sativene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66261", "l": "CoA + IC-asc-C7-AMP => AMP + H(+) + IC-asc-C7-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690701", "l": "SHP1 binds p-CD22 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75240", "l": "acetyl-CoA + N-terminal L-methionyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37634", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66421", "l": "ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) => ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65576", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate = an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22176", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.94", "l": "\"leukotriene-B4 20-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.338568301456235", "identifiers": [{"i": "GO:0016712", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58502", "l": "glyoxylate + H2O + NAD(+) + trimethylamine => glycine betaine + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103062", "l": "cis-keto-C60-meroacyl-AMP ligase activity", "d": ["Catalysis of the reaction: ATP(4-) + H2O + a cis-keto-C60-meroacyl-[acp] = diphosphoric acid + a cis-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53540", "l": "(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37891", "l": "aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol", "d": [], "t": []}, {"i": "EC:3.1.1.95", "l": "\"aclacinomycin methylesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913456", "l": "Interleukin-5 receptor alpha subunit binds Interleukin-5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49040", "l": "(-)-5'-demethylyatein + S-adenosyl-L-methionine = (-)-yatein + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.330", "l": "\"5'-demethylyatein 5'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202714", "l": "CD58 binds CD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822539", "l": "VWF multimer binds to collagen type I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578965", "l": "TNRC6A binds AGO2:miRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848436", "l": "PTK6 phosphorylates CDKN1B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237102", "l": "Transamination of MOB to methionine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1006143", "l": "CD46 binds C3b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39642", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA <=> (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851436", "l": "CFHR dimers bind C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428909", "l": "Activated TP receptor binds G-protein  G13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70971", "l": "D-dopa + H2O + O2 = 3-(3,4-dihydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25929", "l": "3-methylquinoline + A + H2O => 3-methylquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684275", "l": "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013435", "l": "RHOD auto-activates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668404", "l": "TNFA binds TNFR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12797", "l": "(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + scopolamine + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.13", "l": "\"6beta-hydroxyhyoscyamine epoxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426032", "l": "DAG is metabolized by DAGL to 2-AG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004835", "l": "tubulin-tyrosine ligase activity", "d": ["Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099580", "l": "monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential", "d": ["Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912393", "l": "MAML in complex with NICD1 recruits CDK8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004644", "l": "phosphoribosylglycinamide formyltransferase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37816", "l": "(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 => 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13863", "l": "D-xylono-1,5-lactone + H(+) + NADH => D-xylose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35584", "l": "2-dehydro-3-deoxy-D-gluconate => D-glyceraldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75885", "l": "ADP-1-deoxy-1,O(4)-didehydro-D-ribose + nicotinamide => NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67241", "l": "(R)-S-adenosyl-L-methionine + H2O => adenosine + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57194", "l": "glycolate + H(+) + L-lysyl-[protein] => H2O + N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77962", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol <=> a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202489", "l": "Oligomerization of Bcl10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237160", "l": "MTA is cleaved and phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58040", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + H2O = (9Z,12Z,15Z)-octadecatrienoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018754", "l": "GDIs bind RHOH (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29370", "l": "CMP + H2O <=> cytidine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032034", "l": "myosin II head/neck binding", "d": ["Binding to the head/neck region of a myosin II heavy chain."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.1", "l": "\"purine-nucleoside phosphorylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610026", "l": "Defective GALK1 does not phosphorylate Gal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70431", "l": "2 H(+)(out) + Li(+)(in) = 2 H(+)(in) + Li(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70849", "l": "L-arginine(out) + L-cysteine(in) + Na(+)(in) => L-arginine(in) + L-cysteine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16602", "l": "L-aspartate => fumarate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2152276", "l": "Secretion of transmembrane collagens (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69182", "l": "AMP + thiamine triphosphate => ADP + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20587", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin => loganin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139898", "l": "Caspase-8 activates BID by cleavage (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17433", "l": "A + choline = AH2 + betaine aldehyde", "d": [], "t": []}, {"i": "EC:1.1.99.1", "l": "\"choline dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28541", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) <=> ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5246478", "l": "APOM binds retinoids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717469", "l": "NS2 (1B) binds DDX58 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004352", "l": "glutamate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5250210", "l": "ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63524", "l": "2-propylphenol + H(+) + NADH + O2 = 3-propylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42891", "l": "(R)-3-phosphomevalonate + ATP <=> (R)-3,5-bisphosphomevalonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21540", "l": "N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.24", "l": "\"phosphoribosylanthranilate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39472", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.4.-", "l": "\"Linked to decarboxylation\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382057", "l": "Release of novel PDGFs as latent factors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55674", "l": "4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26114", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799350", "l": "Exocytosis of specific granule membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59274", "l": "D-cysteine => L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45824", "l": "H(+) + L-serine = CO2 + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202713", "l": "CD84 homodimerises (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445752", "l": "Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222491", "l": "Lactoferrin scavenges iron ions (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16441", "l": "H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.44", "l": "\"protein-glutamine glutaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46751", "l": "carboxyphosphate + NH4(+) <=> carbamate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78049", "l": "1-O-alkyl-2-acetyl-3-acylglycerol + a 2-acyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264622", "l": "Cho is acetylated to AcCho by CHAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1218824", "l": "HSP90 is inactivated by binding to benzaquinoid ansamycins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35875", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592239", "l": "Expression of PEO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35438", "l": "cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose <=> cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40482", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24831", "l": "ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate => ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211193", "l": "Homodimerization  of DFF40 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784402", "l": "Spontaneous hydrolysis of 1-pyrroline-3-hydroxy-5-carboxylate to 4-OH-L-glutamate semialdehyde (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13658", "l": "acetyl-[citrate lyase ACP] + H2O => acetate + H(+) + holo-[citrate lyase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047356", "l": "CDP-ribitol ribitolphosphotransferase activity", "d": ["Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748991", "l": "XDH oxidises 6MP to 6TU (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68370", "l": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP => 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26036", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033134", "l": "ubiquitin activating enzyme binding", "d": ["Binding to a ubiquitin activating enzyme, any of the E1 proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0004935", "l": "adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53076", "l": "cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine = 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57956", "l": "dimethyl sulfoxide + H(+) + NADH + O2 = dimethyl sulfone + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70868", "l": "L-alanine(out) + L-glutamine(in) + Na(+)(out) => L-alanine(in) + L-glutamine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50989", "l": "prostaglandin F2alpha(out) => prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39447", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786190", "l": "CMBL hydrolyses OM to OLMS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56246", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein] => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679045", "l": "C-ter TLR9 dimer binds HCQ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735179", "l": "GATA4 and LEF1:CTNNB1 bind the ISL1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23355", "l": "2-oxoglutarate + 4-aminobutanoate <=> L-glutamate + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16073", "l": "2,2-dialkylglycine + H(+) + pyruvate = CO2 + dialkyl ketone + L-alanine", "d": [], "t": []}, {"i": "EC:4.1.1.64", "l": "\"2,2-dialkylglycine decarboxylase (pyruvate)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16638", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine => [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13942", "l": "ATP + D-glyceraldehyde => ADP + D-glyceraldehyde 3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56926", "l": "ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein] => ATP + L-threonyl-[Goodpasture antigen-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903231", "l": "mRNA base-pairing translational repressor activity", "d": ["A translation repressor activity that acts by base-pairing with an mRNA. The binding can result in targeting the mRNA for degradation or interfering with mRNA translation, hence resulting in posttranscriptional gene silencing."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75849", "l": "SLC25A1 exchanges CIT and MAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112510", "l": "IL6ST is tyrosine phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24387", "l": "ATP + deamido-NAD(+) + H2O + L-glutamine <=> AMP + diphosphate + H(+) + L-glutamate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.1.-", "l": "\"Other isomerases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2430535", "l": "MASTL phosphorylates ENSA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70837", "l": "L-arginine(out) + L-glutamine(in) + Na(+)(in) => L-arginine(in) + L-glutamine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58648", "l": "rifamycin SV hemiaminal = H(+) + rifamycin SV ortho-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52534", "l": "AMP + GDP + H(+) => adenosine + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25524", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = 9alpha-copalyl diphosphate", "d": [], "t": []}, {"i": "EC:5.5.1.14", "l": "\"syn-copalyl-diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31412", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine => a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70058", "l": "AH2 + cremeomycin <=> 2-hydroxy-4-methoxybenzoate + A + N2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49974", "l": "16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52884", "l": "H2O + N-phenylhydroxylamine + 2 NADP(+) = 2 H(+) + 2 NADPH + nitrobenzene", "d": [], "t": []}, {"i": "EC:1.7.1.16", "l": "\"nitrobenzene nitroreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29441", "l": "Fe(2+)(out) + H(+)(in) => Fe(2+)(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875816", "l": "STAT3 binds activated MET receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19583", "l": "discadenine + H(+) + S-methyl-5'-thioadenosine => N(6)-dimethylallyladenine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18449", "l": "A + arsenite + H2O = AH2 + arsenate + H(+)", "d": [], "t": []}, {"i": "EC:1.20.99.1", "l": "\"arsenate reductase (donor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52308", "l": "2-hydroxyglutarate + NADP(+) = 2-oxoglutarate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047026", "l": "androsterone dehydrogenase (A-specific) activity", "d": ["Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61999", "l": "L-lysyl-[protein] + lactoyl-CoA <=> CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66537", "l": "A + cholest-4,6-dien-3-one + H2O => 25-hydroxycholest-4,6-dien-3-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029471", "l": "Hydrolysis of PC to PA by PLD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12311", "l": "(S)-2-amino-6-oxohexanoate + H2O + NAD(+) <=> 2 H(+) + L-2-aminoadipate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29671", "l": "Ca(2+)(in) = Ca(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22865", "l": "L-lysine => D-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990838", "l": "poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends", "d": ["Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59974", "l": "CoA + O-decanoyl-L-seryl-[protein] => decanoyl-CoA + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15177", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}, {"i": "EC:3.1.1.5", "l": "\"lysophospholipase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56132", "l": "(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA = a thymidine dimer in DNA", "d": [], "t": []}, {"i": "EC:4.1.99.14", "l": "\"spore photoproduct lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694677", "l": "ZCRB1 binds 5'UTR of SARS-CoV-2 genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58971", "l": "1-naphthaldehyde + H2O + O2 <=> 1-naphthoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51954", "l": "2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-167415", "l": "G-protein alpha subunit is inactivated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-517444", "l": "TAT aminates HPP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180003", "l": "S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity", "d": ["Catalysis of the reaction: S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)."], "t": []}, {"i": "RHEA:75479", "l": "S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67028", "l": "(glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O = (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835411", "l": "FA core complex:HSP70s binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62323", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) <=> (+)-isomalbrancheamide B + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102822", "l": "quercetin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine = H+ + isorhamnetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5333051", "l": "RPA1 binds HSF1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905763", "l": "MTREC complex binding", "d": ["Binding to a MTREC complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2429719", "l": "MCPH1 sequesters condensin II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11635", "l": "AH2 + L-selenocysteine <=> A + H(+) + hydrogenselenide + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033509", "l": "USP9X binds Ub:PEX5L (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802910", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36755", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.305", "l": "\"UDP-Glc:alpha-D-GlcNAc-glucosaminyl-diphosphoundecaprenol beta-1,3-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016084", "l": "myostimulatory hormone activity", "d": ["The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11004", "l": "2 H(+) + NADH + O2 + salicylate = catechol + CO2 + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.1", "l": "\"salicylate 1-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14652", "l": "demethyllactenocin + dTDP-beta-L-mycarose <=> demethylmacrocin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9838093", "l": "LONP1 binds mitochondrial matrix proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59419", "l": "H2O + O2 + tryptamine <=> H2O2 + indole-3-acetaldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:1901683", "l": "arsenate ion transmembrane transporter activity", "d": ["Enables the transfer of an arsenate ion from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209177", "l": "LGS:ARM complex transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53146", "l": "H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018594", "l": "MECP2 binds LBR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669868", "l": "Nilotinib-resistant KIT mutants do not bind nilotinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24629", "l": "2 H2O + 3 NAD(+) + NH4(+) => 5 H(+) + 3 NADH + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186786", "l": "Autophosphorylation of PDGF beta receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31299", "l": "H2O + NAD(+) + perillyl aldehyde = 2 H(+) + NADH + perillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62903", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose <=> alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44955", "l": "(2E)-octenoyl-CoA + H(+) + NADPH <=> NADP(+) + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29846", "l": "ATP + CoA + propanoate <=> ADP + phosphate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-114284", "l": "Release of Cytochrome c from mitochondria (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730501", "l": "SARS-CoV-2 3CLpro dimer binds to STING (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46862", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP => 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47803", "l": "4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid <=> an aromatic oxo-acid + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44590", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-1D-myo-inositol => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28509", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP <=> 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047411", "l": "2-(acetamidomethylene)succinate hydrolase activity", "d": ["Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870465", "l": "RGGT binds the RAB-binding subunit (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013023", "l": "RHOB GEFs activate RHOB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41354", "l": "a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60256", "l": "A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3] = AH2 + formaldehyde + L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2514865", "l": "cGMP dissociates from CNG channels (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38968", "l": "an N-acylsphing-4-enine(in) + ATP + H2O => ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21657", "l": "CDP-alpha-D-paratose => CDP-3,6-dideoxy-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40918", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38245", "l": "1-O-eicosanyl (9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + eicosan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.2", "l": "\"beta-amylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033847", "l": "O-phosphoserine sulfhydrylase activity", "d": ["Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.88", "l": "\"L-glutamate gamma-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1912357", "l": "ITCH ubiquitinates DTX (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169406", "l": "ISGylation of host proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43422", "l": "1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428909", "l": "Activated TP receptor binds G-protein  G13 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856945", "l": "PP2A methylation by LCMT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64286", "l": "2-phenylacetaldehyde + L-alanine => 2-phenylethylamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940134", "l": "FOLR2 binds FOLA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216988", "l": "Monoubiquitination of PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16573", "l": "2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052826", "l": "inositol hexakisphosphate 2-phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40138", "l": "(9Z)-tetradecenoyl-CoA + H2O <=> (9Z)-tetradecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350168", "l": "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428259", "l": "DEGS1 dehydrogenates dihydroceramide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613207", "l": "EGR1 binds to the EGR1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29866", "l": "AMP + GTP <=> ADP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.55", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54532", "l": "H2O + N-(4-oxoglutaryl)-L-cysteinylglycine = 2-oxoglutarate + L-cysteinylglycine", "d": [], "t": []}, {"i": "EC:3.5.1.128", "l": "\"deaminated glutathione amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73116", "l": "quercetin + S-adenosyl-L-methionine => H(+) + rhamnetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26529", "l": "a (3R)-3-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11931", "l": "hydroxylamine + NH4(+) <=> H(+) + H2O + hydrazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29681", "l": "formate(out) => formate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35473", "l": "(+)-pisatin + H(+) + S-adenosyl-L-homocysteine => (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676255", "l": "Formation of the MLL2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102926", "l": "solanidine glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + solanidine = H+ + gamma-chaconine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210426", "l": "Glutamate synaptic vesicle docking and priming (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68803", "l": "H2O + nigerose <=> alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71813", "l": "3,3',5-triiodo-L-thyronine(in) => 3,3',5-triiodo-L-thyronine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46314", "l": "3,22-dioxochol-4-en-24-oyl-CoA + CoA => 3-oxochol-4-en-22-oyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047647", "l": "alkylacetylglycerophosphatase activity", "d": ["Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O = 2-acetyl-1-alkyl-sn-glycerol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005136", "l": "interleukin-4 receptor binding", "d": ["Binding to an interleukin-4 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9833635", "l": "p-PKR dimer localizes to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374667", "l": "DCC interaction with SIAH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11590", "l": "AH2 + isoquinolin-1(2H)-one => A + H2O + isoquinoline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55525", "l": "H(+) + H2O + L-dopa + O2 => 3,4-dihydroxyphenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052723", "l": "inositol hexakisphosphate 1-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.5", "l": "\"bacterial ABC-type protein transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47858", "l": "a ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate => a ganglioside GD1a (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30444", "l": "2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc => 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68379", "l": "glyoxylate + L-asparagine <=> 2-oxosuccinamate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654422", "l": "Activated FGFR4 binds FRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33004", "l": "(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0031409", "l": "pigment binding", "d": ["Binding to a pigment, a general or particular coloring matter in living organisms, e.g. melanin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209828", "l": "Tryptophan is hydroxylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247836", "l": "Retromer recycles WLS to the Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78431", "l": "1-O-alkyl-2-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-2,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75997", "l": "3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out) => 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18795", "l": "D-ribose 5-phosphate => alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030883", "l": "endogenous lipid antigen binding", "d": ["Binding to an endogenous cellular lipid antigen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421831", "l": "trans-Golgi Network Coat Assembly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66402", "l": "ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycocholate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47408", "l": "(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O = (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030796", "l": "cycloartenol 24-C-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299318", "l": "Activation of TASK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018768", "l": "RHOU auto-activates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0022883", "l": "zinc efflux transmembrane transporter activity", "d": ["Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77608", "l": "Binding of A1CF to stem-looped RNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28621", "l": "2-methylbutyronitrile + H(+) + NADPH + O2 <=> 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24231", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) <=> 4-methylcatechol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68078", "l": "a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP => a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848392", "l": "IL18BP binds IL18 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29183", "l": "menaquinol-8 + 2 O2 = 2 H(+) + menaquinone-8 + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195733", "l": "M2 protein synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77523", "l": "butanal + hydrogen cyanide = (2S)-2-hydroxypentanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59767", "l": "L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA <=> CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061896", "l": "all-trans retinol 3,4-desaturase activity", "d": ["Catalysis of the reaction: all-trans-retinol + 2 H+ + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinol + 2 H2O + 2 oxidized [adrenodoxin]."], "t": []}, {"i": "RHEA:50292", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.53", "l": "\"all-trans-retinol 3,4-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940554", "l": "MMP2 cleaves OPTC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60669", "l": "(R,R)-chrysanthemol + NAD(+) => (1R,3R)-chrysanthemal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63815", "l": "ATP + N(8)-citryl-spermidine + spermidine <=> AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678981", "l": "TLR9 processing at neutral pH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198958", "l": "KIR2DL2/3 interacting with HLA-C group 1 (Cw4) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34817", "l": "curcumin + 2 H(+) + 2 NADPH => 2 NADP(+) + tetrahydrocurcumin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36707", "l": "O-ureido-L-serine = O-ureido-D-serine", "d": [], "t": []}, {"i": "EC:5.1.1.19", "l": "\"O-ureido-serine racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49938", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53882", "l": "ADP + alpha,alpha-trehalose 6-phosphate + H(+) => ADP-alpha-D-glucose + D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70631", "l": "H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570528", "l": "SUMOylation of XPC with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27662", "l": "(S)-2-hydroxyglutarate + O2 = 2-oxoglutarate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174058", "l": "Degradation of multiubiquitinated Cdh1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626549", "l": "IQGAPs bind CALM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29424", "l": "ATP + diphosphate => ADP + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818937", "l": "MEN1 binds MLL1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54866", "l": "4-methylpent-3-en-1-yl acetate + H2O + NADP(+) => H(+) + NADPH + O2 + sulcatone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810843", "l": "Envoplakin binds periplakin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47984", "l": "H2O + presqualene diphosphate = diphosphate + hydroxysqualene", "d": [], "t": []}, {"i": "EC:4.2.3.156", "l": "\"hydroxysqualene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40563", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050146", "l": "nucleoside phosphotransferase activity", "d": ["Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72298", "l": "malate(out) + 3 Na(+)(out) <=> malate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433711", "l": "Cis-homodimerization of nectins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72172", "l": "2 Na(+)(out) + taurohyocholate(out) => 2 Na(+)(in) + taurohyocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77030", "l": "D-serine + H2O + NAD(+) <=> 3-hydroxypyruvate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029272", "l": "Release of PLCG from FCGR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62407", "l": "(R)-2-hydroxyhexadecanoate + O2 <=> CO2 + H2O + pentadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35382", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA <=> (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033416", "l": "UGG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785762", "l": "IL13RA1 binds TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5609939", "l": "Defective PGM1 does not isomerise G6P to G1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37823", "l": "(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78714", "l": "3-O-beta-D-glucosyl-D-glucuronate + phosphate <=> aldehydo-D-glucuronate + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015527", "l": "glycerol-phosphate:phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + phosphate(in) = glycerol phosphate(in) + phosphate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0048038", "l": "quinone binding", "d": ["Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052609", "l": "4-ketotorulene 3-hydroxylase activity", "d": ["Catalysis of the reaction: 4-ketotorulene + a reduced electron acceptor + oxygen = 3-hydroxy-4-ketotorulene + an oxidized electron acceptor + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016844", "l": "strictosidine synthase activity", "d": ["Catalysis of the reaction: 3alpha(S)-strictosidine + H2O = secologanin + tryptamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37729", "l": "1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22358", "l": "CO2 + phosphate + phosphoenolpyruvate => diphosphate + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66812", "l": "5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH = 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798257", "l": "PTPRS binds NTRK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44717", "l": "A + all-trans-4,4'-diapolycopen-4-al + H2O => AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47816", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52998", "l": "[eIF5A protein]-deoxyhypusine + NAD(+) => [eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75422", "l": "(R,S)-butane-2,3-diol + NAD(+) <=> (S)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41143", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10190", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+) => acetoacetyl-CoA + acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015227", "l": "acyl carnitine transmembrane transporter activity", "d": ["Enables the transfer of acyl carnitine from one side of a membrane to the other. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane."], "t": []}, {"i": "REACT:R-HSA-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052674", "l": "ent-pimara-9(11),15-diene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-9(11),15-diene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47049", "l": "a quinone + shikimate => 3-dehydroshikimate + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879910", "l": "JAK2 is phosphorylated, activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29233", "l": "cyanate(out) => cyanate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33824", "l": "3-(4-hydroxycyclohex-2-en-1-ylidene)pyruvate + H(+) + NADH => NAD(+) + tetrahydro-4-hydroxyphenylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78084", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => 1-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25395", "l": "(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": [], "t": []}, {"i": "EC:1.13.11.60", "l": "\"linoleate 8R-lipoxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190265", "l": "FGFR4 binds to FGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35104", "l": "fusidate(in) => fusidate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69053", "l": "RFC binding displaces Pol Alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65514", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2 => 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63031", "l": "(15Z)-tetracosenamide + H2O <=> (15Z)-tetracosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49387", "l": "(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29969", "l": "2'-deoxyuridine(out) + H(+)(out) => 2'-deoxyuridine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858346", "l": "AMHR2 binds AMH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928597", "l": "EPH:EFN dimers tetramerise (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019811", "l": "cocaine binding", "d": ["Binding to cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937989", "l": "RUNX1 binds PRC1 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76453", "l": "(E)-4-coumaraldehyde + AH2 => (E)-4-coumaroyl alcohol + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374298", "l": "Opioid receptors bind opioid peptides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050422", "l": "strictosidine beta-glucosidase activity", "d": ["Catalysis of the reaction: 3alpha(S)-strictosidine + H2O = D-glucose + strictosidine aglycone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14232", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25036", "l": "all-trans-retinol + NADP(+) <=> all-trans-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111883", "l": "Hydrolysis of phosphatidylcholine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928576", "l": "RHOA:GTP binds ROCK, activating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030628", "l": "pre-mRNA 3'-splice site binding", "d": ["Binding to a pre-mRNA 3' splice site sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640114", "l": "Misfolded proteins translocate from cilium to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75000", "l": "deoxyerythrostominol(in) => deoxyerythrostominol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42238", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111930", "l": "Adenylate cyclase produces cAMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25201", "l": "D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose 6-phosphate", "d": [], "t": []}, {"i": "EC:4.1.2.43", "l": "\"3-hexulose-6-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10971", "l": "a carboxylate + CoA + GTP <=> an acyl-CoA + GDP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64695", "l": "isobutanol + NAD(+) <=> 2-methylpropanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50210", "l": "cortisone + H(+) + NADH => cortisol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60417", "l": "diglucosyl-enterobactin + H2O => H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60746", "l": "CoA + pyrethrin I => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65004", "l": "ATP + decanoate + holo-[ACP] = AMP + decanoyl-[ACP] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866277", "l": "AP-2 directly binds some endocytic cargo (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42098", "l": "AMP + diphosphate + H(+) + nebramycin 5' + phosphate => ATP + carbamoyl phosphate + H2O + tobramycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18393", "l": "(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.40", "l": "\"(R)-3-amino-2-methylpropionate--pyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211239", "l": "SIRT1 deacetylates TAF1B in SL1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68155", "l": "a 1,3-diacylglycerol + a fatty acyl-CoA <=> a triacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51421", "l": "a (2S,3S)-flavan-3-ol + 2 NADP(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448744", "l": "IL20RA binds IL20RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042283", "l": "dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity", "d": ["Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22472", "l": "(R)-pantetheine + ATP = (R)-4'-phosphopantetheine + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.34", "l": "\"pantetheine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019807", "l": "aspartoacylase activity", "d": ["Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9846501", "l": "B3GNT5 transfers GlcNAc to LacCer (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63852", "l": "dodecanoate + O2 = (2R)-2-hydroperoxydodecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55602", "l": "a mannosylinositol-1-phosphoceramide + GDP + H(+) => an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25682", "l": "L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27642", "l": "adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63164", "l": "H2O + N-tricosanoyl-taurine = taurine + tricosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062060", "l": "NuA4 histone acetyltransferase complex binding", "d": ["Binding to a NuA4 histone acetyltransferase complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78584", "l": "acetyl-CoA + eicosanoyl-CoA => 3-oxodocosanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43208", "l": "5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.229", "l": "\"tRNA (carboxymethyluridine(34)-5-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62971", "l": "(R)-lactate + NADP(+) <=> H(+) + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693783", "l": "NAALADases hydrolyse NAAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60749", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone => CoA + pyrethrin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026377", "l": "NTF4-bound NTRK2 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70362", "l": "3-oxosphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45320", "l": "H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine = H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14134", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60239", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75933", "l": "taurine + urea => H2O + taurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45179", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018365", "l": "protein-serine epimerase activity", "d": ["Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43056", "l": "5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH = 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.239", "l": "\"10-deoxymethynolide syntase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30530", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate <=> ADP + ATP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37428", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66392", "l": "ATP + H2O + prostaglandin E1(in) = ADP + H(+) + phosphate + prostaglandin E1(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.377", "l": "\"L-rhamnose 1-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692809", "l": "CDC42 binds effectors at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9866217", "l": "HCCS inserts heme into cytochrome c (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032003", "l": "interleukin-28 receptor binding", "d": ["Binding to an interleukin-28 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3777129", "l": "HDAC3 containing complexes deacetylate histone (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3782535", "l": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56179", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O <=> 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9704248", "l": "CHRM4 binds CHRM4 antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22937", "l": "H2O + N-acetyl-D-glucosamine 6-phosphate => acetate + D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913370", "l": "Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54238", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1,2-didecanoyl-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009558", "l": "IL34 dimer binds SDC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45387", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044729", "l": "hemi-methylated DNA-binding", "d": ["Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24218", "l": "(2E,6E)-farnesoate + 2 H(+) + NADH => (2E,6E)-farnesal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48554", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) => 1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785594", "l": "FANCD2 binds FANCI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73395", "l": "L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15070", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a => chlorophyllide a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52878", "l": "16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16beta,17beta-estriol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48186", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16207", "l": "N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate => H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038944", "l": "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019119", "l": "phenanthrene-9,10-epoxide hydrolase activity", "d": ["Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-191303", "l": "FDPS dimer transfers IPPP to GPP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428625", "l": "Vesicular inhibitory amino acid transport (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50478", "l": "CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] => anthraniloyl-CoA + L-cysteinyl-[PqsD protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853965", "l": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29884", "l": "ATP + H2O + L-ornithine(out) => ADP + H(+) + L-ornithine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67133", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH => (1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220964", "l": "NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004397", "l": "histidine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-histidine = urocanate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937613", "l": "CRHBP binds CRH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61109", "l": "(2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.196", "l": "\"limit dextrin alpha-1,6-maltotetraose-hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "38.845724558418894", "identifiers": [{"i": "GO:0003824", "l": "catalytic activity", "d": ["Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9667619", "l": "AVPR1A,B,2 bind atosiban (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58200", "l": "2-oxoglutarate + 6-aminohexanoate = 6-oxohexanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.116", "l": "\"6-aminohexanoate aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45844", "l": "(3R)-hydroxyoctanoyl-CoA + NADP(+) = 3-oxooctanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21069", "l": "A + H2O + nitrite => AH2 + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76968", "l": "a short-chain fatty aldehyde + H2O + NADP(+) => a short-chain fatty acid + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39532", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78291", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = (R,2E)-alpha-cericerene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.219", "l": "\"(2E)-alpha-cericerene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17350", "l": "(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047372", "l": "acylglycerol lipase activity", "d": ["Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22622", "l": "3-indoleglycolaldehyde + CO2 + NH4(+) => H(+) + L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58825", "l": "4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.1", "l": "\"cystathionine gamma-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.292", "l": "\"(phenol)carboxyphthiodiolenone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45163", "l": "3-oxopropanoate + H(+) <=> acetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24122", "l": "20-hydroxy-leukotriene E4 + H2O + NADP(+) => H(+) + leukotriene E4 + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67784", "l": "2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55747", "l": "coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.13", "l": "\"retroviral ribonuclease H\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22573", "l": "A + H2O + N-methyl-L-glutamate => AH2 + formaldehyde + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42934", "l": "2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51789", "l": "2-hydroxybenzoyl-5'-AMP + CoA => 2-hydroxybenzoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42582", "l": "AMP + diphosphate + H(+) + L-seryl-tRNA(Sec) => ATP + L-serine + tRNA(Sec)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68596", "l": "(2E,6E)-farnesyl diphosphate = beta-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44476", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878056", "l": "RUNX1:CBFB binds EP300 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57468", "l": "(E)-ferulate + UDP-alpha-D-glucose = 1-O-[(E)-feruloyl]-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56438", "l": "2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48047", "l": "ganglioside GM1 (d18:1(4E)/18:0) + H2O <=> D-galactose + ganglioside GM2 (d18:1(4E)/18:0)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58841", "l": "cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427514", "l": "eNoSC deacetylates histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36009", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33240", "l": "L-threonine + NAD(+) => aminoacetone + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66227", "l": "asc-C9-CoA + O2 <=> asc-DeltaC9-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40094", "l": "26-hydroxyhexacosanoate + NAD(+) <=> 26-oxohexacosanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851919", "l": "Activated MET binds GAB1 and GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189069", "l": "sucrose + H2O => glucose + fructose (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9854961", "l": "SDHAF4 binds to FAD-SDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10605", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9793485", "l": "PRKN polyubiquitinates RIPK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129375", "l": "Elastin cross-linking by lysyl oxidase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35490", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30380", "l": "(2E,6E)-farnesyl diphosphate => (+)-beta-chamigrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964567", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CDK1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61214", "l": "H(+) + myricetin 3-O-beta-D-glucoside + UDP => myricetin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68795", "l": "alpha-NAD(+) + H2O <=> ADP-D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209100", "l": "MYD88:TUB binds to TL receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3782637", "l": "HDAC8 deacetylates histones (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72578", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O <=> (22R)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28254", "l": "(3Z)-hex-3-en-1-ol + acetyl-CoA = (3Z)-hex-3-en-1-yl acetate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.195", "l": "\"(Z)-3-hexen-1-ol acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1980125", "l": "ITCH binds DTX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433593", "l": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047169", "l": "galactarate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: feruloyl-CoA + galactarate = 2-(E)-O-feruloyl-D-galactarate + CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74059", "l": "beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72663", "l": "De novo formation of eIF2:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42223", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate <=> 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49947", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate <=> (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69876", "l": "6-deoxocastasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxycastasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40855", "l": "FAD + H(+) + undecanoyl-CoA = FADH2 + trans-2-undecenoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78702", "l": "a 3-O-beta-D-glucosyl-beta-D-glucuronoside + phosphate <=> a beta-D-glucuronoside + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28151", "l": "acetyl-CoA + spermidine => CoA + H(+) + N(1)-acetylspermidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72432", "l": "(E)-caffeate + ATP + H(+) => (E)-caffeoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.70", "l": "\"oligopeptidase A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34871", "l": "methanol(out) = methanol(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71656", "l": "an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O => a thymidine in DNA + ADP-D-ribose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71766", "l": "2-oxoglutarate(out) + citrate(in) <=> 2-oxoglutarate(in) + citrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14733", "l": "Ag(+)(in) + ATP + H2O = ADP + Ag(+)(out) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.15", "l": "\"P-type Ag(+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33920", "l": "H(+) + lanosterol + NADPH => 24,25-dihydrolanosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20527", "l": "ADP + H(+) + N(5)-ethyl-L-glutamine + phosphate => ATP + ethylamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371527", "l": "HSF1 trimer translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43901", "l": "dalpatein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O => beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalpatein + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42954", "l": "5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(49) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30405", "l": "Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in) => Fe(3+)(out) + L-ascorbate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50432", "l": "AH2 + prostaglandin G1 = A + H2O + prostaglandin H1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12893", "l": "prostaglandin H2 = prostaglandin E2", "d": [], "t": []}, {"i": "EC:5.3.99.3", "l": "\"prostaglandin-E synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14781", "l": "ATP + CoA + heptanedioate = 6-carboxyhexanoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.14", "l": "\"6-carboxyhexanoate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43166", "l": "7-cyano-7-carbaguanosine(15) in tRNA + guanine => 7-cyano-7-deazaguanine + guanosine(15) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73858", "l": "5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose <=> 5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35573", "l": "(1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28993", "l": "N-acetylneuraminate(out) => N-acetylneuraminate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034936", "l": "4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 4,6-dichloro-3-methylcatechol + O2 = 3,5-dichloro-3-methyl-cis,cis-muconate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83788", "l": "Binding of TFIIIC to Type 2 promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30123", "l": "H2O + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51099", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47311", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034810", "l": "4,5-dihydroxybenzo(a)pyrene dioxygenase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + O2 = 4,5-chrysenedicarboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68947", "l": "esculetin + S-adenosyl-L-methionine <=> H(+) + isoscopoletin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798044", "l": "BTG2 binds CCR4-NOT complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203567", "l": "palmitoylation of eNOS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13178", "l": "6-phospho-5-dehydro-2-deoxy-D-gluconate => 3-oxopropanoate + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75949", "l": "L-ornithine + taurocyamine => L-arginine + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53312", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40536", "l": "4 H(+) + narbomycin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + novapikromycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67422", "l": "a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+) => a glycerophospholipid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56695", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54115", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + selina-4(15),7(11)-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15006", "l": "2-oxoglutarate + gibberellin A1 + O2 => CO2 + gibberellin A8 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44177", "l": "a 2,3-diacyl-sn-glycerol + H2O => a 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.80179338545976", "identifiers": [{"i": "GO:0016616", "l": "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168885", "l": "Haptoglobin binds Hemoglobin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38475", "l": "L-histidine + S-adenosyl-L-methionine = H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473584", "l": "Collagen type III degradation by MMP15 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76900", "l": "cyclohexylamine + H2O + NADP(+) => cyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45133", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446187", "l": "ALG11 transfers the fourth and fifth Man to the N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33299", "l": "[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine", "d": [], "t": []}, {"i": "EC:2.5.1.46", "l": "\"deoxyhypusine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75153", "l": "diphosphate + neoverrucosan-5beta-ol => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114558", "l": "Thrombin-activated PARs activate Gq (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39662", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol <=> a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030342", "l": "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68113", "l": "H2O + propanamide => NH4(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157124", "l": "NOTCH3 binds JAG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14372", "l": "2-phosphoglycolate + H2O <=> glycolate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25226", "l": "L-arabinitol + NAD(+) => H(+) + L-arabinose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174438", "l": "Formation of the Flap Intermediate on the C-strand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62905", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483174", "l": "PE is methylated to PC by PEMT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37375", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20432", "l": "apigenin + S-adenosyl-L-methionine <=> acacetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17589", "l": "2,2'-iminodipropanoate + H2O + NAD(+) = H(+) + L-alanine + NADH + pyruvate", "d": [], "t": []}, {"i": "EC:1.5.1.17", "l": "\"alanopine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47223", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67119", "l": "N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16537", "l": "(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.76", "l": "\"lipid-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5617179", "l": "PRKACA phosphorylates TNNI3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54858", "l": "ethyl hexanoate + H2O + NADP(+) => H(+) + NADPH + O2 + octan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050071", "l": "phosphatidylglycerol lysyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62980", "l": "(9Z)-hexadecenamide + H2O = (9Z)-hexadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11408", "l": "H(+) + H2O + riboflavin = lumichrome + ribitol", "d": [], "t": []}, {"i": "EC:3.5.99.1", "l": "\"riboflavinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211715", "l": "Proteasome mediated degradation of PAK-2p34 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26404", "l": "all-trans-10'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865454", "l": "CBFB binds RUNX3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51435", "l": "(S)-1-aminoethylphosphonate + acetyl-CoA <=> [(1S)-1-acetamidoethyl]phosphonate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592278", "l": "Autocatalytic activation of proMMP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77958", "l": "cholesterol + UDP-alpha-D-galactose <=> cholesteryl 3-beta-D-galactoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34721", "l": "(2E)-13-methyltetradecenal + phosphoethanolamine => 15-methylhexadecasphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60438", "l": "3-methylbutanol + acetate + H(+) => 3-methylbutyl acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76294", "l": "Na(+)(out) + xanthine(out) <=> Na(+)(in) + xanthine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866304", "l": "pre-VLDL binds lipids to form VLDL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11039", "l": "a quaternary ammonium(out) + ATP + H2O <=> a quaternary ammonium(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58065", "l": "O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin => 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72619", "l": "2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65806", "l": "a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine => a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21180", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = D-glucose + indole-3-acetyl-1D-myo-inositol", "d": [], "t": []}, {"i": "EC:2.3.1.72", "l": "\"indoleacetylglucose--inositol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66875", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67636", "l": "(2S)-2-amino-2'-deoxyadenylo-succinate = dZMP + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46337", "l": "3-oxochola-4,17-dien-22-oyl-CoA + H2O => 17-hydroxy-3-oxochol-4-en-22-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018616", "l": "trihydroxytoluene dioxygenase activity", "d": ["Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674095", "l": "PDGFRs bind type II TKI (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9835121", "l": "Heparin binds PKR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0050736", "l": "O-malonyltransferase activity", "d": ["Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783681", "l": "LIF binds LIFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768925", "l": "MDM2 gene expression is repressed by NPAS4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23647", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hyodeoxycholate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944230", "l": "Association of procollagen type XVIII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57834", "l": "glutarate + 2 H(+) + NADPH => 5-oxopentanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28060", "l": "L-xylulose => L-lyxopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58477", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10174", "l": "2 (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate dimer + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54324", "l": "a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33134", "l": "L-phenylalanine + tetrahydro-4-hydroxyphenylpyruvate <=> 3-phenylpyruvate + tetrahydrotyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10841", "l": "H2O + O-phospho-L-homoserine => L-threonine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35009", "l": "D-fucose(out) => D-fucose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69309", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate => phenylacetonitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10063", "l": "acetyl-CoA + D-tryptophan <=> CoA + H(+) + N-acetyl-D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858500", "l": "CLEC10A binds Tn-MUC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68462", "l": "a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a phenolic steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78664", "l": "gamma-lactone-2-keto[5.5.5.5]fenestrane + H(+) + NADPH + O2 => H2O + NADP(+) + penifulvin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54715", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38172", "l": "hexadecane-1,2-diol + hexadecanoyl-CoA => 2-hydroxyhexadecyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10020", "l": "H2O + L-saccharopine + NADP(+) = (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.10", "l": "\"saccharopine dehydrogenase (NADP(+), L-glutamate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59479", "l": "2 AH2 + 2 ATP + benzoate + L-phenylalanine <=> 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985594", "l": "MYO9B inactivates RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61919", "l": "ATP + fluconazole(in) + H2O <=> ADP + fluconazole(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917696", "l": "Cargo Sequestration (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77409", "l": "(2S)-2-hydroxy-3,3-dimethylbutanenitrile => 2,2-dimethylpropanal + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.514861039037328", "identifiers": [{"i": "GO:0005496", "l": "steroid binding", "d": ["Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10034", "l": "[protein]-C-terminal-L-glutamate + NH4(+) => [protein]-C-terminal-L-glutamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761843", "l": "NFE2L2-dependent GSR gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082356", "l": "HSF1-mediated gene expression (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186786", "l": "Autophosphorylation of PDGF beta receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77796", "l": "an (E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amine + H(+) + H2O => 2-dehydro-D-glucose + an aliphatic amine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48301", "l": "H2O + prostaglandin F2alpha 1-glyceryl ester => glycerol + H(+) + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047483", "l": "imidazoleacetate-phosphoribosyldiphosphate ligase activity", "d": ["Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazol-4-ylacetate = 1-(5-phosphoribosyl)imidazol-4-ylacetate + ADP + diphosphate + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052850", "l": "NADPH-dependent dihydrocurcumin reductase activity", "d": ["Catalysis of the reaction: dihydrocurcumin + NADPH+ + H+ = tetrahydrocurcumin + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12863", "l": "NH4(+) + xanthosine => guanosine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166869", "l": "TRAF6 binds MEKK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67951", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17154", "l": "CDP-D-glucose => CDP-4-dehydro-6-deoxy-D-glucose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11536", "l": "choline + H2O + 2 O2 = glycine betaine + H(+) + 2 H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.17", "l": "\"choline oxidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40310", "l": "A + decanedioyl-CoA <=> (2E)-decenedioyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944099", "l": "Activated PPARG binds PTEN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666433", "l": "IgG binds the surface of the amastigote form of Leishmania (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432010", "l": "Aquaporin-1 passively transports water into cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610722", "l": "CK1 phosphorylates p-GLI3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614614", "l": "Cysteine is degraded to serine and H2S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25014", "l": "H(+) + N,N-dihydroxy-L-tryptophan => (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750226", "l": "NLRC5 binds IKBKB and CHUK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36895", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14707", "l": "CoA-disulfide + H(+) + NADPH => 2 CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018697", "l": "carbonyl sulfide nitrogenase activity", "d": ["Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46758", "l": "a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047554", "l": "2-pyrone-4,6-dicarboxylate lactonase activity", "d": ["Catalysis of the reaction: 2-oxo-2H-pyran-4,6-dicarboxylate + H2O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018541", "l": "p-benzoquinone reductase (NADPH) activity", "d": ["Catalysis of the reaction: 1,4-benzoquinone + H+ + NADPH = hydroquinone + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28660", "l": "beta-lactose + H2O => beta-D-galactose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75588", "l": "11-O-acetylcyathatriol + UDP-alpha-D-glucose => erinacine Q2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534096", "l": "METAP1/2 demethylates GNAT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37022", "l": "A + D-serine + H2O <=> 3-hydroxypyruvate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18576", "l": "dihydrochelirubine + H(+) + O2 <=> chelirubine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-555065", "l": "Formation of clathrin coated vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28111", "l": "chloride + S-adenosyl-L-methionine => 5'-chloro-5'-deoxyadenosine + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045157", "l": "electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity", "d": ["Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953111", "l": "E2F6 binds TFDP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000254", "l": "C-4 methylsterol oxidase activity", "d": ["Catalysis of the reaction: 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H+ + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.13", "l": "\"manganese peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62018", "l": "3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451466", "l": "TRAF6 binding to activated IRAK2 stimulates its oligomerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65114", "l": "aculene C + CO2 + H2O + succinate => 2-oxoglutarate + aculene D + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39067", "l": "3-oxooctanedioyl-CoA + CoA = acetyl-CoA + hexanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750226", "l": "NLRC5 binds IKBKB and CHUK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709098", "l": "DHFR dimer reduces FOLA to DHF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27330", "l": "H(+) + NADH + O2 + urate => 5-hydroxyisourate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050083", "l": "malyl-CoA lyase activity", "d": ["Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205118", "l": "TRAF6 polyubiquitinates NRIF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32263", "l": "4-aminobutanoate + pyruvate = L-alanine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39104", "l": "ATP + H2O + sitosterol(in) => ADP + H(+) + phosphate + sitosterol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63357", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58504", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = (3Z)-2-oxo-4-carboxy-3-hexenedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102399", "l": "dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose = S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32105", "l": "2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + trans-resveratrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729232", "l": "SARS-CoV-1 nsp1 binds to 40S ribosomal subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62408", "l": "3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine = 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.365", "l": "\"MMP 1-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005546", "l": "phosphatidylinositol-4,5-bisphosphate binding", "d": ["Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73942", "l": "desmethyl-dehydrogriseofulvin + S-adenosyl-L-methionine <=> dehydrogriseofulvin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70155", "l": "6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] = 28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031840", "l": "type 2 neuromedin U receptor binding", "d": ["Binding to a type 2 neuromedin U receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047994", "l": "hydroxymethylglutaryl-CoA hydrolase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086410", "l": "CDK1 phosphorylates BORA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52242", "l": "4 H(+) + 2 MnO2 => 2 H2O + 2 Mn(2+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19946", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9851946", "l": "FIRRM binds PLK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65611", "l": "(4R)-hydroxysphinganine + docosanoyl-CoA <=> CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59497", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37245", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA => (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63471", "l": "all-trans-octaprenol + ATP <=> ADP + all-trans-octaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21517", "l": "isopiperitenone => piperitenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19833", "l": "(6R)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)", "d": [], "t": []}, {"i": "EC:3.5.1.10", "l": "\"formyltetrahydrofolate deformylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68012", "l": "H2O + hypoxanthine + O2 = H2O2 + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14298", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O => an N-acylsphing-4-enine + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77508", "l": "(E)-cinnamaldehyde + hydrogen cyanide => (2S,3E)-2-hydroxy-4-phenylbut-3-enenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864569", "l": "WWOX binds TFAP2C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015496", "l": "putrescine:ornithine antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48285", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose => a globoside NOR1 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22434", "l": "a 3-oxoacyl-CoA + H(+) + NADH => a (3S)-3-hydroxyacyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9010646", "l": "AKAP5 recruits PKC to ROBO3.1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682709", "l": "LGI4 binds ADAM22,23,11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79140", "l": "cholate + L-serine => H2O + L-serocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638137", "l": "EGFRvIII cancer variant does not bind EGF ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.71648590403835", "identifiers": [{"i": "GO:0005231", "l": "excitatory extracellular ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9612219", "l": "ERBB4s80 binds to SRC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65835", "l": "AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O <=> A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46275", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28229", "l": "(+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36584", "l": "dTDP-alpha-D-fucose + NADP(+) => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72672", "l": "The 60S subunit joins the translation initiation complex  (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13839", "l": "4,5-dihydroxyphthalate + H(+) + NADH => cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63527", "l": "2-propylphenol + H(+) + NADH + O2 <=> 3-propylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51463", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamate <=> (9Z)-octadecenoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665389", "l": "Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40864", "l": "FAD + H(+) + heptadecanoyl-CoA => FADH2 + trans-2-heptadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58036", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = 8-epi-inunolide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44752", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58417", "l": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) => (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371554", "l": "HSF1 acetylation at Lys80 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014433", "l": "RHOG GEFs activate RHOG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67063", "l": "asnovolin I + S-adenosyl-L-methionine <=> asnovolin K + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418553", "l": "cAMP degradation by Phosphodiesterases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41695", "l": "1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50838", "l": "14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57710", "l": "4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + H(+) + UDP => (E)-coniferaldehyde + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655142", "l": "RCHY1 binds POLH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53748", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52810", "l": "H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine => adenosine in U6 snRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45160", "l": "3-oxopropanoate + H(+) = acetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858916", "l": "MITF-M-dependent ATP6V1H gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817575", "l": "ERO1B oxidizes P4HB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74554", "l": "H2O + L-seryl-tRNA(Ser) <=> L-serine + tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46387", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69834", "l": "campestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28466", "l": "pyridoxamine(in) = pyridoxamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43560", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13268", "l": "1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine <=> 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41493", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52395", "l": "ATP + D-erythronate <=> 4-phospho-D-erythronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0005326", "l": "neurotransmitter transmembrane transporter activity", "d": ["Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.63", "l": "\"beta-carotene 4-ketolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66867", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + quiannulatene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465924", "l": "OPN1LW binds 11cRAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047902", "l": "formylaspartate deformylase activity", "d": ["Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2301205", "l": "SETD8 monomethylates histone H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36641", "l": "3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine => 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620788", "l": "FOXO1,FOXO3,FOXO4 binds RBL2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16902", "l": "acetyl-CoA + L-2,4-diaminobutanoate => (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11516", "l": "H2O + succinyl-CoA = CoA + H(+) + succinate", "d": [], "t": []}, {"i": "EC:3.1.2.3", "l": "\"succinyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34419", "l": "(+)-lariciresinol + NADP(+) = (+)-pinoresinol + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.23.1.1", "l": "\"(+)-pinoresinol reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20237", "l": "(1S,4S)-5-oxo-1,2-campholide = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49536", "l": "2-amino-2-deoxy-D-gluconate = (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003837", "l": "beta-ureidopropionase activity", "d": ["Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0070330", "l": "aromatase activity", "d": ["Catalysis of the reduction of an aliphatic ring to yield an aromatic ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30009", "l": "ADP + H(+) + L-arabinose(in) + phosphate => ATP + H2O + L-arabinose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38221", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38721", "l": "(R)-carnitine(in) + ADP + H(+) + phosphate => (R)-carnitine(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17022", "l": "(2-aminoethyl)phosphonate + pyruvate => L-alanine + phosphonoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383190", "l": "HCO3- transport through ion channel (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11015", "l": "H2O + L-tryptophanamide <=> L-tryptophan + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33771", "l": "a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9824999", "l": "GSK3B phosphorylates p-S73 MITF-M at residue S69 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047695", "l": "benzoin aldolase activity", "d": ["Catalysis of the reaction: benzoin = 2 benzaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018768", "l": "RHOU auto-activates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78216", "l": "D-glutamine + H2O + O2 => 2-oxoglutaramate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953013", "l": "E2F7 binds E2F8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64176", "l": "H2O + N-(9Z-octadecenoyl)-L-tryptophan = (9Z)-octadecenoate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56157", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine => (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63745", "l": "UDP-alpha-D-glucuronate + zolasartan => UDP + zolarsartan-1-N-beta-D-glucuronide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76911", "l": "(1S)-3-methyl-cyclohexylamine + H2O + NAD(+) = 3-methylcyclohexanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60358", "l": "anthranilate + H(+) + octanoate => H2O + N-octanoylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61234", "l": "(S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-isoleucine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035242", "l": "protein-arginine omega-N asymmetric methyltransferase activity", "d": ["Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659782", "l": "Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825848", "l": "MITF-M dimer, SOX10, pS133 CREB1 and CTNNB1:LEF1 bind the DCT gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016496", "l": "substance P receptor activity", "d": ["Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849646", "l": "SPINK5(490-624) binds KLK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75351", "l": "2 Fe(III)-[cytochrome c] + H2O + pseudooxynicotine = 4-oxo-4-(pyridin-3-yl)butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) + methylamine", "d": [], "t": []}, {"i": "EC:1.4.2.3", "l": "\"pseudooxynicotine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28762", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose <=> alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9653514", "l": "USP17L2 deubiquitinates RCE1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62680", "l": "naphtopyrone YWA1 = H(+) + H2O + norrubrofusarin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112435", "l": "Formation of Elongin BC complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13522", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.28", "l": "\"tropomyosin kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78421", "l": "2-aminobenzimidazole + CO2 => H(+) + N-(1H-1,3-benzodiazol-2-yl)carbamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875591", "l": "DOCK7 activates RAC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28989", "l": "H(+)(out) + N-acetylneuraminate(out) => H(+)(in) + N-acetylneuraminate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6794347", "l": "Homer1,2,3 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58670", "l": "3-deoxyglucosone + H(+) + NADPH => 3-deoxyfructose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16066", "l": "2-oxoglutarate + O2 + phytanoyl-CoA => 2-hydroxyphytanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200646", "l": "Cytosolic folate export across the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42730", "l": "2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2791) in 21S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864577", "l": "TFAP2C translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047197", "l": "triglyceride-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53495", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) <=> 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60559", "l": "uridine(35) in tRNA(Tyr) <=> pseudouridine(35) in tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38340", "l": "(20S)-ginsenoside Rb1 + H2O => (20S)-ginsenoside Rd + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43564", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine = [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate", "d": [], "t": []}, {"i": "EC:2.6.1.108", "l": "\"(5-formylfuran-3-yl)methyl phosphate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39589", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+) => 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66791", "l": "N-methyl-L-dopa + O2 <=> (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174058", "l": "Degradation of multiubiquitinated Cdh1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419166", "l": "GEFs activate RhoA,B,C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19944", "l": "norcoclaurine + S-adenosyl-L-methionine <=> coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67891", "l": "3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine <=> 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420975", "l": "Ca impermeable AMPA receptor ligand binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24156", "l": "2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP", "d": [], "t": []}, {"i": "EC:2.7.2.14", "l": "\"branched-chain-fatty-acid kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170978", "l": "p-FRS2:CRKL binds C3G (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58864", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63705", "l": "mycophenolate + UDP-alpha-D-glucuronate => H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010488", "l": "UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050318", "l": "tannase activity", "d": ["Catalysis of the reaction: digallate + H2O = 2 gallate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41454", "l": "3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+) => 5-methyl-1-naphthoate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237129", "l": "Acireductone is created (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050104", "l": "L-gulonate 3-dehydrogenase activity", "d": ["Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050816", "l": "phosphothreonine residue binding", "d": ["Binding to a phosphorylated threonine residue within a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013021", "l": "GDIs block activation of RHOB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14444", "l": "acetyl-CoA + gentamicin C <=> CoA + H(+) + N(3)-acetylgentamycin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27995", "l": "H2O + xanthosine => D-ribose + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33373", "l": "alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein] => alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58161", "l": "ent-copalyl diphosphate => diphosphate + dolabradiene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52458", "l": "H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP => testosterone + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856157", "l": "LAG3 (CD233) binds MHC II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9824732", "l": "G or G analog binds C-ter TLR7 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47048", "l": "a quinone + shikimate = 3-dehydroshikimate + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9702818", "l": "CALCR binds erenumab (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33245", "l": "(E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21429", "l": "(2R)-3-sulfolactate => H(+) + pyruvate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097626", "l": "low-affinity L-arginine transmembrane transporter activity", "d": ["Enables the transfer of L-arginine from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825772", "l": "SIRT1 deacetylates HINT1 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20547", "l": "3-hydroxy-L-kynurenine + H2O + NADP(+) => H(+) + L-kynurenine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665706", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39191", "l": "(2E)-docosenoyl-CoA + H(+) + NADPH = docosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0043515", "l": "kinetochore binding", "d": ["Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54648", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.173", "l": "\"ent-8alpha-hydroxylabd-13-en-15-yl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034857", "l": "2-(methylthio)benzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112379", "l": "Recruitment of elongation factors to form elongation complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79111", "l": "cholate + L-arginine = H2O + L-arginocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264848", "l": "apoA-I binds to CUBN:AMN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11611", "l": "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + n acetyl-CoA <=> [N,O(9)-diacetyl-alpha-D-neuraminosyl-(2->8)](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811431", "l": "RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29137", "l": "a menaquinone + 2 H(+)(out) + H2O + nitrite => a menaquinol + 2 H(+)(in) + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57726", "l": "CO2 + 2 Na(+)(out) + pyruvate => H(+) + 2 Na(+)(in) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32348", "l": "2 S-adenosyl-L-methionine + tricetin => 3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38147", "l": "carbon disulfide + H2O = carbonyl sulfide + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52939", "l": "3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O <=> (3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0030553", "l": "cGMP binding", "d": ["Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114544", "l": "p115-RhoGEF activation of RHOA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11272", "l": "a (2R)-2-hydroxycarboxylate + a quinone = a 2-oxocarboxylate + a quinol", "d": [], "t": []}, {"i": "EC:1.1.5.10", "l": "\"D-2-hydroxyacid dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26456", "l": "acryloyl-CoA + H(+) + NADPH => NADP(+) + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71183", "l": "L-kynurenine(out) + L-tryptophan(in) = L-kynurenine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53385", "l": "5,10-methylenetetrahydromethanopterin + NAD(+) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033040", "l": "sour taste receptor activity", "d": ["Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40417", "l": "2,6,10,14-tetramethylpentadecanoate + CoA + H(+) => H2O + pristanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111930", "l": "Adenylate cyclase produces cAMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47165", "l": "4alpha-carboxyzymosterol + NAD(+) => CO2 + NADH + zymosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23358", "l": "ADP + H(+) + O-phospho-L-seryl-[rhodopsin] => ATP + L-seryl-[rhodopsin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28471", "l": "pyridoxine(in) => pyridoxine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990526", "l": "Recruitment of ITCH and K48 ubiquitination of MAVS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36453", "l": "ADP + glycyl-L-glutamate(in) + H(+) + phosphate => ATP + glycyl-L-glutamate(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444433", "l": "Cho transports from the extracellular space to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64438", "l": "glycylglycyl-L-isoleucine(in) + H(+)(in) => glycylglycyl-L-isoleucine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25888", "l": "dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate", "d": [], "t": []}, {"i": "EC:2.5.1.72", "l": "\"quinolinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13272", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O <=> an N-acylsphing-4-enine + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247844", "l": "WNT ligands traffic to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160050", "l": "xanthine binding", "d": ["Binding to xanthine, a purine base."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662608", "l": "MT2A binds cadmium (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9856871", "l": "MDH1 reduces OA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419166", "l": "GEFs activate RhoA,B,C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444202", "l": "Receptor FFAR1 binds free fatty acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63930", "l": "an N-acyl-sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71375", "l": "2 Na(+)(out) + testosterone 17-sulfate(out) = 2 Na(+)(in) + testosterone 17-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033455", "l": "GCA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GCA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791121", "l": "Expression of XBP1(S) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32183", "l": "cholesterol + O2 = cholest-5-en-3-one + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.6", "l": "\"cholesterol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50802", "l": "prostaglandin A2-S-(S)-glutathione => glutathione + prostaglandin A2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33704", "l": "(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080081", "l": "4-methylumbelliferyl-beta-D-glucopyranoside beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of glucosidic link in 4-methylumbelliferyl-beta-D-glucopyranoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45487", "l": "H(+) + pyruvate <=> acetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36330", "l": "ADP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374665", "l": "DCC interaction with SIAH1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36015", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27370", "l": "acetoin + CoA + NAD(+) => acetaldehyde + acetyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684290", "l": "nsp3 is glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483174", "l": "PE is methylated to PC by PEMT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36500", "l": "2-dehydro-3-deoxy-L-rhamnonate + NAD(+) => 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013435", "l": "RHOD auto-activates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32784", "l": "ATP + glycine betaine(out) + H2O => ADP + glycine betaine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73797", "l": "FAICAR => IMP + H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51798", "l": "colupulone + diphosphate + H(+) => deoxycohumulone + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51995", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60791", "l": "gibberellin A24 + H(+) + O2 <=> CO2 + gibberellin A9 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27757", "l": "H2O + methylglyoxal <=> (R)-lactate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53867", "l": "3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+) <=> 7,12-dioxo-lithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56476", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 = (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25311", "l": "glycolate + O2 = glyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59246", "l": "acetate + ADP-D-ribose + H(+) => 3''-O-acetyl-ADP-D-ribose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48333", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61645", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine => 2 Fe(III)-[cytochrome b5] + H2O + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9846332", "l": "FUT1,2 transfer fucose to gangliosides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212432", "l": "Formation of DRIP coactivator complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26439", "l": "3-hydroxypropanoate + NADP(+) => 3-oxopropanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73923", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine = griseophenone D + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35173", "l": "H(+)(in) + novobiocin(out) => H(+)(out) + novobiocin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5262921", "l": "Defective IKBKG (NEMO) destabilizes the association of IKBKA:IKBKB:IKBKG (via TLR) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45151", "l": "3-(methylsulfanyl)acryloyl-CoA + H2O <=> 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427570", "l": "Group 3 - Selective Cl- transport (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75445", "l": "heme b(out) => heme b(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725855", "l": "NR3C2 binds NR3C2 antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381644", "l": "ER calcium channels open in response to activated PKA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141100", "l": "tRNA (guanine(18)-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 18 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 18 in tRNA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55094", "l": "H(+) + sucrose + UDP => D-fructose + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44168", "l": "dodecanoate + 2 H(+) + NADH = dodecanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682709", "l": "LGI4 binds ADAM22,23,11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52047", "l": "mogrol + UDP-alpha-D-glucose <=> H(+) + mogroside IE + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19883", "l": "diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein] => GTP + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52722", "l": "5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+) => 5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37998", "l": "all-trans-nonaprenyl diphosphate + H(+) + homogentisate <=> 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45520", "l": "phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]", "d": [], "t": []}, {"i": "EC:4.4.1.31", "l": "\"phycoerythrocyanin alpha-cysteine-84 phycoviolobilin lyase/isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43463", "l": "dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950426", "l": "Expression of lymphocyte cytosolic protein 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428231", "l": "ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9856871", "l": "MDH1 reduces OA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47227", "l": "dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165127", "l": "GEF binds to the inactive DRheb (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56729", "l": "4-hydroxy-all-trans-beta-carotene + AH2 + O2 => 4,4-dihydroxy-all-trans-beta-carotene + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420117", "l": "VEGFR2 autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43907", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32537", "l": "4-hydroxy-2-oxohexanoate => (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1250264", "l": "TXNIP binds reduced thioredoxin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55069", "l": "a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68569", "l": "N(5)-hydroxy-L-ornithine => (3S)-1,2-diazinane-3-carboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51108", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782388", "l": "NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64242", "l": "CoA + H(+) + N-octanoylglycine => glycine + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12295", "l": "ATP + L-serine + tRNA(Ser) <=> AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10574", "l": "(2E)-butenoyl-CoA => vinylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70676", "l": "H2O + Met-enkephalin-Arg-Phe => L-arginyl-L-phenylalanine + Met-enkephalin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.323347803118935", "identifiers": [{"i": "GO:0042287", "l": "MHC protein binding", "d": ["Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990119", "l": "RNA helicase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an RNA helicase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371554", "l": "HSF1 acetylation at Lys80 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44975", "l": "(R)-carnitine + hexanoyl-CoA <=> CoA + O-hexanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140616", "l": "iodotyrosine deiodinase activity", "d": ["Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. Note that this activity has only been demonstrated in the direction of 3-deiodination. 3-bromo-L-tyrosine and 3-chloro-L-tyrosine can also be used as substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246478", "l": "APOM binds retinoids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25239", "l": "ADP + CTP => ATP + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9854961", "l": "SDHAF4 binds to FAD-SDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32523", "l": "nigerose + phosphate = beta-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.279", "l": "\"nigerose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22906", "l": "gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34669", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => C30 botryococcene + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29378", "l": "AMP + H2O <=> adenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102223", "l": "4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming)", "d": ["Catalysis of the reaction: 4 H+ + 15-cis-4,4'-diapophytoene + 4 FAD = 4,4'-diapolycopene + 4 FADH2. This reaction consists of three successive dehydrogenations that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'-diapophytofluene, 4,4'-diapo-zeta-carotene and 4,4'-diapolycopene as intermediates, and 4,4'-diapolycopene as the end product."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46882", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15204", "l": "6-hydroxymellein + S-adenosyl-L-methionine <=> 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26312", "l": "1,4-dihydroxy-2-naphthoyl-CoA + H2O <=> 1,4-dihydroxy-2-naphthoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33516", "l": "2 5,6-dihydroxyindole + O2 => 2 H2O + 2 indole-5,6-quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950128", "l": "Interleukin-12 dissociates from Interleukin-12 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28021", "l": "enterobactin + 3 H2O <=> 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005154", "l": "epidermal growth factor receptor binding", "d": ["Binding to an epidermal growth factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690196", "l": "USP8 deubiquitinates RNF128 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53369", "l": "5,6-dihydrouridine(17) in tRNA + NADP(+) => H(+) + NADPH + uridine(17) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3221982", "l": "BANP binds TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61090", "l": "(2R,3R)-dihydroquercetin + CO2 + succinate => (S)-eriodictyol + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018689", "l": "naphthalene disulfonate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034912", "l": "phthalate 3,4-cis-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59589", "l": "ATP + beta-alanine + L-ornithine => ADP + beta-alanyl-L-ornithine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707594", "l": "Hemes bind LY96 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27447", "l": "D-xylose + H(+) + NADPH => NADP(+) + xylitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73483", "l": "D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694421", "l": "PP6 dephosphorylates SEC24 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2134532", "l": "TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614614", "l": "Cysteine is degraded to serine and H2S (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983153", "l": "E1 mediated ubiquitin activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74061", "l": "beta-alanine(in) + L-alanine(out) => beta-alanine(out) + L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729741", "l": "SARS-CoV-2 3CLpro dimer cleaves NLRP12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40795", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072552", "l": "monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: monoferuloyl di-(hydroxyferuloyl) spermidine + NADPH + O2 = tri-(hydroxyferuloyl) spermidine + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24536", "l": "L-tryptophan + O2 = N-formyl-L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015395", "l": "nucleoside transmembrane transporter activity, down a concentration gradient", "d": ["Enables the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451310", "l": "Activation of Edited Kainate receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879281", "l": "mycothiol is cleaved to acetylcysteine and glucosaminylinositol (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41625", "l": "3-sulfinopropanoyl-CoA + H2O => H(+) + propanoyl-CoA + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61294", "l": "2-dehydropantoate + H(+) + NADH => (R)-pantoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29488", "l": "(2E,6E)-farnesyl diphosphate => cis-muurola-3,5-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66594", "l": "a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+) => 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29479", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-epicubenol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.64", "l": "\"(+)-epicubenol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011224", "l": "ROBO3.1 binds DCC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47924", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate = (2S)-3-sulfolactaldehyde + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.2.58", "l": "\"2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48726", "l": "3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide => aurachin B + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1980125", "l": "ITCH binds DTX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374899", "l": "Release of noradrenaline  at the synapse (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051034", "l": "tRNA transmembrane transporter activity", "d": ["Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39257", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA + NADP(+) => (13Z)-3-oxodocosenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50386", "l": "5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n) => H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432516", "l": "CLK and CYC bind to form a heterodimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865320", "l": "CBFB binds RUNX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54033", "l": "(6R)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose => (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37821", "l": "1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72305", "l": "L-glutamate(out) + L-thyroxine(in) => L-glutamate(in) + L-thyroxine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467659", "l": "AGRN binds NCAM1, PTPRS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50108", "l": "hexadecanoyl-CoA + taurine = CoA + H(+) + N-hexadecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983422", "l": "Disassembly of COPII coated vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72523", "l": "1,6-dihydroxyphenazine + S-adenosyl-L-methionine = 1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71253", "l": "L-xylulose => L-xylopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015531", "l": "citrate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in)."], "t": []}, {"i": "RHEA:32123", "l": "citrate(in) + H(+)(in) = citrate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013021", "l": "GDIs block activation of RHOB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042931", "l": "enterobactin transmembrane transporter activity", "d": ["Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429860", "l": "DCP1-DCP2 complex decaps mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102237", "l": "ATP:farnesol kinase activity", "d": ["Catalysis of the reaction: 2-trans,-6-trans-farnesol + ATP = 2-trans,-6-trans-farnesyl monophosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24248", "l": "glyoxylate + L-alanine = glycine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700992", "l": "TP53 stimulates MDM2 transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684052", "l": "PIAS4 SUMOylates MDC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618559", "l": "EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18584", "l": "ethanolamine + H2O + O2 <=> glycolaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944218", "l": "Association of procollagen type VIII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27821", "l": "L-idonate + NAD(+) <=> 2-dehydro-L-idonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102700", "l": "alpha-thujene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate(3-) = alpha-thujene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22065", "l": "5alpha-ergosta-7,22-diene-3beta,5-diol => ergosterol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41785", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0) => CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61113", "l": "(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354087", "l": "Recruitment of GRB2 to p-PTK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.138", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110215", "l": "Cleavage of uracil by UNG glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40116", "l": "H2O + hexanoyl-CoA => CoA + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22571", "l": "ascopyrone M <=> ascopyrone P", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39949", "l": "a fatty acid + a monoacylglycerol + H(+) => a 1,3-diacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67518", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-nonadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76185", "l": "2 H(+)(in) + L-alanyl-L-alanine(in) => 2 H(+)(out) + L-alanyl-L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69981", "l": "(22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40653", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010437", "l": "9,10 (9', 10')-carotenoid-cleaving dioxygenase activity", "d": ["Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047689", "l": "aspartate racemase activity", "d": ["Catalysis of the reaction: L-aspartate = D-aspartate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429714", "l": "CSNK1G2 phosphorylates p-CERT1-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34504", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-epi-alpha-bisabolol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74486", "l": "(Z)-dehydrocyclopeptine + 2-oxoglutarate + O2 <=> (-)-cyclopenine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10307", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60250", "l": "AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] => A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27348", "l": "FMNH2 + O2 <=> 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374701", "l": "Phosphorylation of DCC by Fyn (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29470", "l": "H(+)(out) + K(+)(in) <=> H(+)(in) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43245", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0032393", "l": "MHC class I receptor activity", "d": ["Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000827", "l": "inositol-1,3,4,5,6-pentakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021596", "l": "Membrane estrogen receptors bind SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371527", "l": "HSF1 trimer translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73744", "l": "2 H(+)(out) + serotonin(in) => 2 H(+)(in) + serotonin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66702", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40104", "l": "H2O + propanoyl-CoA => CoA + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0032404", "l": "mismatch repair complex binding", "d": ["Binding to a mismatch repair complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432527", "l": "Nuclear PP2A dephosphorylates phosphorylated PER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34989", "l": "(S)-lactate(out) => (S)-lactate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.151", "l": "\"alkylcobalamin dealkylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14523", "l": "(2E)-geranial + H(+) + NADPH => (2E)-geraniol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49112", "l": "phenazine-1-carboxylate + S-adenosyl-L-methionine = 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.327", "l": "\"phenazine-1-carboxylate N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52304", "l": "H2O + L-ectoine = (2S)-2-acetamido-4-aminobutanoate", "d": [], "t": []}, {"i": "EC:3.5.4.44", "l": "\"ectoine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63571", "l": "beta-casomorphin-7 + H2O <=> beta-casomorphin-6 + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903880", "l": "17alpha-hydroxyprogesterone binding", "d": ["Binding to 17alpha-hydroxyprogesterone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69607", "l": "acetyl-CoA + N-terminal L-methionyl-[tubulin] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]", "d": [], "t": []}, {"i": "EC:2.3.1.308", "l": "\"tubulin N-terminal N-acetyltransferase NAT9\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66631", "l": "(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 <=> (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018646", "l": "1-hydroxy-2-oxolimonene 1,2-monooxygenase activity", "d": ["Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58757", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49390", "l": "H(+) + UDP + validamycin A => UDP-alpha-D-glucose + validoxylamine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9853376", "l": "FIGNL1 binds SPIDR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72594", "l": "D-glucuronate(out) + H(+)(out) <=> D-glucuronate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030348", "l": "syntaxin-3 binding", "d": ["Binding to a syntaxin-3 SNAP receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375151", "l": "Interaction of NCAM1 with collagens (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800797", "l": "The PIDDosome activates CASP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694442", "l": "CNIH2,3 bind GRIA1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9676257", "l": "Formation of the SET1A complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675790", "l": "MTORC1 dissociates from ULK complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10418", "l": "2-benzylsuccinate => fumarate + toluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782138", "l": "ERCC5 and RPA bind TC-NER site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50303", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29320", "l": "H2O + sn-glycero-3-phosphoethanolamine => ethanolamine + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061649", "l": "ubiquitin-modified histone reader activity", "d": ["A molecular adaptor that recognizes and binds a histone protein containing a ubiquitination modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445448", "l": "HHIP binds Hedgehog (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.n3", "l": "\"Dictyostelium lysozyme A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67189", "l": "ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out) => ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2272668", "l": "Interaction of DAP12 and KIR2DS5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42957", "l": "cytidine(38) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733203", "l": "FURIN gene transcription is stimulated by SMAD2/SMAD3:SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53074", "l": "2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9902096", "l": "COX18 inserts nascent MT-CO2 in COX20:TMEM77 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74742", "l": "Phosphorylation of SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-427570", "l": "Group 3 - Selective Cl- transport (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74362", "l": "coproporphyrin I(out) <=> coproporphyrin I(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14144", "l": "AMP + glutathione disulfide + 2 H(+) + sulfite <=> adenosine 5'-phosphosulfate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9609921", "l": "SGTA binds Tail-anchored protein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11154", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP(+) => 5-pyridoxate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22719", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.30", "l": "\"isobutylamine N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727349", "l": "XDH dehydrogenates xanthine to form urate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68610", "l": "Formation of ORC(2-5) complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9726509", "l": "NR3C2 binds fludrocortisone (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617458", "l": "HOXA1 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60989", "l": "(E)-hex-2-en-1-ol + NAD(+) => (E)-hex-2-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40151", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40931", "l": "2-oxoglutarate + L-ornithine + O2 = (3S)-3-hydroxy-L-ornithine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76249", "l": "ADP + ergothioneine(in) + H(+) + phosphate => ATP + ergothioneine(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875558", "l": "RAPGEF1 binds CRK,CRKL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44432", "l": "2 a 1-acylglycerol = a 1,2-diacylglycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865505", "l": "SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77061", "l": "3-methylcyclopentanone + H(+) + NADPH + NH4(+) => 3-methylcyclopentanamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17287", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199518", "l": "C3d-complexed antigen binds to complement receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46675", "l": "aldosterone + H(+) + NADPH <=> 5beta-dihydroaldosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66154", "l": "CoA + H(+) + N-acetylnoradrenaline => acetyl-CoA + noradrenaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839107", "l": "BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63107", "l": "H(+) + ilicicolin A epoxide + NADPH + O2 <=> 16-hydroxy-ilicicolin A epoxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75862", "l": "Fall Back to Closed Pre-initiation Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32267", "l": "4-aminobutanoate + glyoxylate = glycine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18161", "l": "acetyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.155", "l": "\"acetyl-CoA C-myristoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60792", "l": "3 2-oxoglutarate + gibberellin A53 + 3 O2 = 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56776", "l": "(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69210", "l": "(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate => (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033852", "l": "thyroid-hormone transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 3,5,3'-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72619", "l": "eIF2:GTP is hydrolyzed, eIFs are released  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005068", "l": "transmembrane receptor protein tyrosine kinase adaptor activity", "d": ["The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66438", "l": "H(+) + NADPH + pent-1-en-3-one => NADP(+) + pentan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062062", "l": "oligosaccharyltransferase complex binding", "d": ["Binding to an oligosaccharyltransferase complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964550", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds E2F1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62874", "l": "H2O + NADP(+) + semiviriditoxin => (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032896", "l": "palmitoyl-CoA 9-desaturase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51812", "l": "ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458875", "l": "WNT binds to FZD and LRP5/6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3785711", "l": "Telomere shortening during replicative exhaustion (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56018", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) => H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159773", "l": "Furin cleaves pro-protein S to protein S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53739", "l": "a 2-halobenzoate + H(+) + NADH + O2 <=> a halide anion + catechol + CO2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58933", "l": "4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH => 5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51718", "l": "AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in) => ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49781", "l": "docosanoyl-CoA + glycine => CoA + H(+) + N-docosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57306", "l": "glycolate + GMP + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40992", "l": "(E)-4-coumaroyl-CoA + H2O => 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24775", "l": "7(1)-hydroxychlorophyllide a + NADP(+) <=> chlorophyllide b + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45464", "l": "eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.10", "l": "\"icosanoyl-CoA 5-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71942", "l": "2-oxoglutarate(out) + 3 Na(+)(out) <=> 2-oxoglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080105", "l": "6-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 6-methylthiopropyl-glucosinolate = 6-methylsulfinylpropyl-glucosinolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43335", "l": "adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14219", "l": "[thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein] => [thioredoxin]-disulfide + H2O + L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928576", "l": "RHOA:GTP binds ROCK, activating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62119", "l": "H2O + iminosuccinate <=> NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73404", "l": "(2R,3R)-tartrate(in) + sulfate(out) => (2R,3R)-tartrate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45412", "l": "H2O + prostaglandin D2-1-glycerol ester = glycerol + H(+) + prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15542", "l": "DIMBOA + UDP-alpha-D-glucose => DIMBOA beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64249", "l": "decanoyl-CoA + glycine => CoA + H(+) + N-decanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29377", "l": "adenosine + phosphate => AMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49057", "l": "asperlicin C + H(+) + NADPH + O2 => asperlicin E + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15747", "l": "[(2->1)-beta-D-fructosyl](n+1) + D-glucose => [(2->1)-beta-D-fructosyl](n) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26015", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate => 3-dehydroquinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56071", "l": "an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0034328", "l": "decanoyltransferase activity", "d": ["Catalysis of the transfer of a decanoyl (CH3-[CH2]8-CO-) group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374723", "l": "Nociceptin receptor binds to nociceptin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785594", "l": "FANCD2 binds FANCI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45059", "l": "deoxynogalonate + O2 <=> H(+) + H2O + nogalonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507870", "l": "Aquaporins passively transport water out of cells (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102664", "l": "indole-3-acetyl-leucine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-leucine + ATP = H+ + indole-3-acetyl-leucine + diphosphoric acid + AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63511", "l": "a 1,2-saturated fatty acid + O2 <=> a (2R)-2-hydroperoxy fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419351", "l": "PAF receptor binds platelet activating factor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34486", "l": "4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA <=> 4-hydroxybenzalacetone + 2 CO2 + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295613", "l": "SPRY2 binds GRB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005358", "l": "high-affinity glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46886", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75957", "l": "CO2 + formaldehyde + oripavine + succinate => 2-oxoglutarate + O2 + thebaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199910", "l": "MSK1 activates ATF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2995330", "l": "COX10 transforms heme to heme O (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58751", "l": "desmethylnectriapyrone + S-adenosyl-L-methionine <=> H(+) + nectriapyrone + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20179", "l": "5'-O-beta-D-glucosylpyridoxine + H(+) + UDP => pyridoxine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33972", "l": "5''-phosphoribostamycin + H2O => phosphate + ribostamycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11788", "l": "H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62823", "l": "1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64397", "l": "glycyl-sarcosine(out) + H(+)(out) => glycyl-sarcosine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73241", "l": "H(+) + ladanein + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + scutellarein 7-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42410", "l": "(2R)-2,3-bisphosphoglycerate + ADP + H(+) => (2R)-2-phosphoglycerate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48971", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 <=> [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71439", "l": "L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31757", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde => 2-oxepin-2(3H)-ylideneacetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14154", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine => 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10205", "l": "dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] => formaldehyde + methylamine + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.9", "l": "\"(R)-2-hydroxyacyl-CoA dehydratase activating ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41914", "l": "hexadecanoyl-[ACP] + NADP(+) => (2E)-hexadecenoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849055", "l": "PTK6 binds ARHGAP35 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54978", "l": "(3S)-hydroxytetradecanoate + CoA + H(+) => (3S)-hydroxytetradecanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41442", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate => (2-aminoethyl)phosphonate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17888", "l": "acetaldehyde <=> acetylene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12626", "l": "(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose => D-glucose + sinapoyl (S)-malate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3828025", "l": "DCN (decorin) degradation by MMP14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33524", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O => acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45569", "l": "[heparosan](n) => [acharan](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23041", "l": "2-oxobutanoate + acetyl-CoA + H2O => (R)-2-ethylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63011", "l": "(6Z)-octadecenamide + H2O <=> (6Z)-octadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14017", "l": "ATP + beta-nicotinamide D-riboside = ADP + beta-nicotinamide D-ribonucleotide + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.22", "l": "\"ribosylnicotinamide kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66543", "l": "7-dehydrocholesterol + A + H2O <=> AH2 + cholesta-5,7-dien-3beta,25-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43082", "l": "2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71181", "l": "FAH cleaves 4FAA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30300", "l": "2-oxoglutarate + a methylated nucleobase within DNA + O2 => a nucleobase within DNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420243", "l": "GHRH receptor binds GHRH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63604", "l": "[Pyr1]apelin-13 + H2O = [Pyr1]apelin-12 + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30971", "l": "7,7',9,9'-tetra-cis-lycopene = all-trans-lycopene", "d": [], "t": []}, {"i": "EC:5.2.1.13", "l": "\"prolycopene isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8863727", "l": "STON2 is neddylated (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16546", "l": "formyl-CoA + oxalate => formate + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70036", "l": "6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39997", "l": "a fatty acid + ethanolamine => an N-acylethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49050", "l": "1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin] => 25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008747", "l": "N-acetylneuraminate lyase activity", "d": ["Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25297", "l": "acetaldehyde + H2O + NAD(+) <=> acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710480", "l": "Decitabine triphosphate incorporates into DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17151", "l": "an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an organic molecule + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165162", "l": "Phosphorylation of TSC2 by PKB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140762", "l": "glucose dehydrogenase (FAD, quinone) activity", "d": ["Catalysis of the reaction: a quinone + D-glucose = a quinol + D-glucono-1,5-lactone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800798", "l": "The PIDDosome binds CASP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37577", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29277", "l": "L-isoleucine(out) + Na(+)(out) => L-isoleucine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66492", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-galctosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13914", "l": "L-threonine => D-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761421", "l": "CDH11 associates with catenins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63915", "l": "6-azauridine + ATP <=> 6-azauridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54889", "l": "(1S,2S)-OPC-8 + ATP + CoA => AMP + diphosphate + OPC8-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016964", "l": "alpha-2 macroglobulin receptor activity", "d": ["Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61757", "l": "stevioside + UDP-alpha-D-glucose => H(+) + rebaudioside A + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73795", "l": "dimethylallyl diphosphate + neoechinulin A = diphosphate + isoechinulin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.162", "l": "\"lambda-carrageenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097246", "l": "catechin binding", "d": ["Binding to a catechin, a polyphenolic antioxidant plant metabolite with a flavonoid or flavan-3-ol structure."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52817", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35660", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose => GDP + H(+) + mannosylinositol phosphorylphytoceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782859", "l": "TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50754", "l": "2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O => 2 naphthalene-1,2,4,8-tetrol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52916", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427514", "l": "eNoSC deacetylates histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065355", "l": "Secreted ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73700", "l": "ADP(in) + dATP(out) => ADP(out) + dATP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55377", "l": "2 a quinol + O2 => 2 a quinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67819", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O <=> a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0016002", "l": "sulfite reductase activity", "d": ["Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23315", "l": "2 sucrose <=> 1(F)-beta-D-fructosylsucrose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45667", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22327", "l": "H2O + leukotriene A4 <=> leukotriene B4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50836", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1638845", "l": "CERK phosphorylates CERA to form C1P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52125", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9858590", "l": "DLST transfers glutaryl to CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37223", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781814", "l": "USP19 deubiquitinates RNF123 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161735", "l": "PGC2 is isomerised to PGB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994148", "l": "LRRC16A binds F-actin capping protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72187", "l": "H(+)(out) + sucrose(out) = H(+)(in) + sucrose(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51508", "l": "2-oxoglutarate + L-proline + O2 = CO2 + succinate + trans-4-hydroxy-L-proline", "d": [], "t": []}, {"i": "EC:1.14.11.57", "l": "\"L-proline trans-4-hydroxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18422", "l": "acetyl-CoA + chloramphenicol => chloramphenicol 3-acetate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602624", "l": "Defective TRAF3 does not transmit the signal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48291", "l": "a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GD3 + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20018", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 => 5,10-methylenetetrahydromethanopterin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696491", "l": "CNTF binds CNTFR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78380", "l": "L-cysteinyl-[protein] + S-nitroso-CoA => CoA + S-nitroso-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854466", "l": "VLDLR binds RELN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25231", "l": "H(+) + L-arabinose + NADPH => L-arabinitol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42774", "l": "N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61611", "l": "[DsbB protein]-dithiol + a quinone <=> [DsbB protein]-disulfide + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16384", "l": "L-arabinitol + NAD(+) <=> H(+) + L-xylulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29804", "l": "ATP + H2O + L-valine(out) => ADP + H(+) + L-valine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164840", "l": "ADP and Pi bind to ATPase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20336", "l": "ATP + L-seryl-[acetyl-CoA carboxylase] <=> ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943811", "l": "MECOM (EVI1) binds the PTEN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27695", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate => (S)-3-methyl-2-oxopentanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59216", "l": "(indol-3-yl)acetate + H(+) = CO2 + skatole", "d": [], "t": []}, {"i": "EC:4.1.1.115", "l": "\"indoleacetate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9716947", "l": "ESR1 binds ESR1 agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30956", "l": "9,9'-di-cis-zeta-carotene + 2 a quinone => 7,7',9,9'-tetra-cis-lycopene + 2 a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421835", "l": "trans-Golgi Network Vesicle Scission (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047201", "l": "beta-glucogallin O-galloyltransferase activity", "d": ["Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31165", "l": "(2E)-hexadecenoyl-CoA + H2O => (3S)-hydroxyhexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29015", "l": "phosphate(out) + sn-glycerol 3-phosphate(in) = phosphate(in) + sn-glycerol 3-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004057", "l": "arginyl-tRNA--protein transferase activity", "d": ["Catalysis of the reaction: an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H+ + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47903", "l": "a ganglioside GM3 (d18:1(4E)) + H2O <=> a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53663", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15902", "l": "(2R)-2-phosphoglycerate => (2R)-3-phosphoglycerate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72369", "l": "estrone 3-sulfate(in) + succinate(out) => estrone 3-sulfate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60860", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-adenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22984", "l": "carbamoyl phosphate + oxamate = N-carbamoyl-2-oxoglycine + phosphate", "d": [], "t": []}, {"i": "EC:2.1.3.5", "l": "\"oxamate carbamoyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43911", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O <=> D-galactose + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41182", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-oxononanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39595", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH = (10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11539", "l": "choline + H2O + 2 O2 <=> glycine betaine + H(+) + 2 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987039", "l": "JAK1 binds IL20RA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63740", "l": "2-phenylacetaldehyde + H(+) + NADH = 2-phenylethanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29608", "l": "H2O + NAD(+) + nitrous oxide => H(+) + NADH + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23306", "l": "H(+) + tropate + tropine => atropine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731924", "l": "EDNRA binds EDNs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35531", "l": "cyclo(L-phenylalanyl-L-leucyl) + 2 O2 = albonoursin + 2 H2O2", "d": [], "t": []}, {"i": "EC:1.3.3.13", "l": "\"albonoursin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37692", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25711", "l": "L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33747", "l": "a 1-acyl-sn-glycerol + ATP = a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28825", "l": "H(+)(out) + L-galactonate(out) => H(+)(in) + L-galactonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45251", "l": "butanoate(out) <=> butanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161195", "l": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10147", "l": "a ribonucleoside 3'-phosphate + H2O <=> a ribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63788", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55983", "l": "a 1,2-saturated acyl-CoA + an acyl-CoA + H2O <=> an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43575", "l": "A + D-arginine + H2O <=> 5-guanidino-2-oxopentanoate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204863", "l": "Interaction of Tie2 with Ang2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981621", "l": "Neuroglobin:oxygen dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64618", "l": "(E)-coniferyl acetate + CoA => (E)-coniferol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70010", "l": "anthranilate + ATP + H(+) <=> 2-aminobenzoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63495", "l": "H(+) + menadione + NADPH <=> menadiol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75210", "l": "Ag(+)(out) <=> Ag(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017056", "l": "structural constituent of nuclear pore", "d": ["The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048270", "l": "methionine adenosyltransferase regulator activity", "d": ["Binds to and modulates the activity of methionine adenosyltransferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55099", "l": "(3S)-3-hydroxypentanoyl-CoA + H2O <=> (3S)-3-hydroxypentanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.17", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64402", "l": "an L-amino acid tripeptide(in) + H(+)(in) => an L-amino acid tripeptide(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9613497", "l": "Unwinding DNA for the nascent transcript (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76942", "l": "2-methylpropan-1-amine + H2O + NADP(+) <=> 2-methylpropanal + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45657", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192123", "l": "CYP27A1 27-hydroxylates CHOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53672", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73596", "l": "dCMP + H2O => dUMP + NH4+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68603", "l": "(2S)-3-sulfopropanediol <=> 3-oxopropane-1-sulfonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40577", "l": "CoA + glutarate + H(+) => glutaryl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58165", "l": "(2E,6E)-farnesyl diphosphate + 2 H2O => 7-epi-ent-eudesmane-5,11-diol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198813", "l": "GSTO dimers reduce DeHA to AscH- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662608", "l": "MT2A binds cadmium (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76482", "l": "hexadecane-1,16-diol + O2 <=> H2O2 + hydroxyhexadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74595", "l": "(2S,3R)-3-methyl-L-aspartate = mesaconate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30211", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrous oxide = 2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide", "d": [], "t": []}, {"i": "EC:1.7.2.5", "l": "\"nitric-oxide reductase (cytochrome c)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60114", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + H2O => (R)-3-(indol-3-yl)lactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36884", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34813", "l": "dihydrocurcumin + H(+) + NADPH => NADP(+) + tetrahydrocurcumin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9728664", "l": "GLP1R binds GLP1R agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607756", "l": "TRAF6 oligomer autoubiquitinates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047028", "l": "6-pyruvoyltetrahydropterin 2'-reductase activity", "d": ["Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624954", "l": "INPP5E translocates to the primary cilium (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74558", "l": "(S)-malate(out) <=> (S)-malate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234159", "l": "Proteasome proteolyzes ub-HIF-alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71944", "l": "(S)-malate(out) + 3 Na(+)(out) => (S)-malate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62895", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA <=> 6 CO2 + 7 CoA + 2 H2O + nor-toralactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60404", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O = Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.794758999417795", "identifiers": [{"i": "GO:0015279", "l": "store-operated calcium channel activity", "d": ["A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores."], "t": []}, {"i": "REACT:R-HSA-434798", "l": "CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51641", "l": "(9Z,12Z)-octadecadienoate + O2 => (11R)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18771", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53154", "l": "H(+) + H2O + N-(20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10756", "l": "ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201457", "l": "BMP2 binds to the receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9668335", "l": "CHMP7 binds LEMD2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706399", "l": "RHOBTB3 hydrolyzes ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13409", "l": "7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH", "d": [], "t": []}, {"i": "EC:1.7.1.13", "l": "\"preQ1 synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507869", "l": "Aquaporins passively transport glycerol into cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30381", "l": "(+)-beta-chamigrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53753", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55749", "l": "coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.26.-", "l": "\"Glutamic endopeptidases\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031797", "l": "type 2 metabotropic GABA receptor binding", "d": ["Binding to a type 2 metabotropic GABA receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20387", "l": "(2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+) => (2R,3R)-dihydroquercetin + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61893", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76733", "l": "a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O => a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54274", "l": "(3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44873", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16569", "l": "2-oxoglutarate + L-lysyl-[collagen] + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.4", "l": "\"procollagen-lysine 5-dioxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031759", "l": "Edg-6 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-6 sphingosine 1-phosphate receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14307", "l": "AMP + diphosphate + L-prolyl-tRNA(Pro) => ATP + L-proline + tRNA(Pro)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47130", "l": "AMP + deoxycholoyl-CoA + diphosphate => ATP + CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51568", "l": "(25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170159", "l": "Translocation of Cdc25 to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57694", "l": "2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein] => 2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50471", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH <=> 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61363", "l": "ATP + H2O + pheophorbide a(in) <=> ADP + H(+) + pheophorbide a(out) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22599", "l": "cephalosporin C + H2O <=> acetate + deacetylcephalosporin C + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870678", "l": "Cleaved fibrinogen products bind TLR4:LY96 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046980", "l": "tapasin binding", "d": ["Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35180", "l": "6 H(+) + hexanoyl-[ACP] + 7 malonyl-CoA => 7 CO2 + 7 CoA + 2 H2O + holo-[ACP] + noranthrone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47611", "l": "3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47605", "l": "a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GP1calpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66007", "l": "coenzyme M + methyl-Co(III)-[glycine betaine-specific corrinoid protein] <=> Co(I)-[glycine betaine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28920", "l": "4-aminobutanoate(in) + L-glutamate(out) => 4-aminobutanoate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19978", "l": "3'-phosphoadenylyl sulfate + L-tyrosine methyl ester => adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77110", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71823", "l": "3,3'-diiodo-L-thyronine(out) = 3,3'-diiodo-L-thyronine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58542", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-dodecanoylglycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47820", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 = 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62106", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052822", "l": "DNA-3-methylguanine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9670673", "l": "FIX is secreted (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983307", "l": "IL15 binds IL15RA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66409", "l": "ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O => ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21239", "l": "anthranilate + 2 H(+) + NADPH + O2 <=> 2,3-dihydroxybenzoate + NADP(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31942", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] <=> DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54450", "l": "a tRNA + an N-acyl-L-amino acid + H(+) => an N-acyl-L-alpha-aminoacyl-tRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16177", "l": "H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47453", "l": "(2E,5Z)-tetradecadienoyl-CoA + H2O => (3S)-hydroxy-(5Z-tetradecenoyl)-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59171", "l": "ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate <=> AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58698", "l": "H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide => NADPH + O2 + rifampicin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73310", "l": "H(+)(in) + L-aspartate(out) + phosphate(in) <=> H(+)(out) + L-aspartate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.356143166865166", "identifiers": [{"i": "GO:0015081", "l": "sodium ion transmembrane transporter activity", "d": ["Enables the transfer of sodium ions (Na+) from one side of a membrane to the other."], "t": []}, {"i": "RHEA:34963", "l": "Na(+)(in) = Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9853499", "l": "DLD dimer dehydrogenates dihydrolipoyl (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0046583", "l": "monoatomic cation efflux transmembrane transporter activity", "d": ["Enables the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164832", "l": "ATPase synthesizes ATP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661230", "l": "MT1A binds arsenic (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420128", "l": "SRC-1 phosphorylates SHB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507869", "l": "Aquaporins passively transport glycerol into cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72861", "l": "A[3'-5']pA[3'-5']pAp[3'] + H(+) => 3',3',3'-c-tri-AMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.170", "l": "\"2-(omega-methylthio)alkylmalate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14964", "l": "H2O + S-formylglutathione <=> formate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20809", "l": "acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-7-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58173", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => beta-pinacene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40564", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 => dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31008", "l": "(S)-2,3-epoxysqualene => beta-amyrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25419", "l": "AH2 + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944232", "l": "Association of procollagen type XII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864433", "l": "TFAP2A,TFAP2C homodimers stimulate CGA gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70797", "l": "H(+)(out) + L-lysine(in) => H(+)(in) + L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.27", "l": "\"choloyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035529", "l": "NADH pyrophosphatase activity", "d": ["Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.3.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71684", "l": "2 H(+)(out) + L-aspartyl-glycine(out) => 2 H(+)(in) + L-aspartyl-glycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940001", "l": "RUNX2:CBFB binds the MMP13 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49830", "l": "(2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.16", "l": "\"vitamin D3 24-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028583", "l": "Phosphorylation of YAP by LATS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38116", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol => 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549322", "l": "OCT1 transports organic cations out of hepatic cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381087", "l": "Dimerization of PERK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36086", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69723", "l": "(indol-3-yl)acetyl-AMP + CoA = (indol-3-yl)acetyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50312", "l": "2-oxopentanoate + H(+) = butanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23038", "l": "2 5'-dehydroinosine + 2 H2O => 2 inosine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75455", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60049", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759809", "l": "miR-451a binds CDH11 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102547", "l": "glucosylglycerate hydrolase activity", "d": ["Catalysis of the reaction: H2O + 2-O-(alpha-D-glucopyranosyl)-D-glycerate = alpha-D-glucose + D-glycerate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6800315", "l": "MST1 binds MST1R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328037", "l": "Fibrillin-1 binds integrins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52348", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75399", "l": "2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(out) = 2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31789", "l": "(13R)-edaxadiene + diphosphate => H2O + tuberculosinyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13912", "l": "phosphate + urate D-ribonucleoside <=> alpha-D-ribose 1-phosphate + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37102", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30913", "l": "a carboxylate + sphing-4-enine-phosphocholine => a sphingomyelin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38829", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14206", "l": "carnosine + S-adenosyl-L-methionine => anserine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43444", "l": "1,2-ditetradecanoyl-sn-glycerol + ATP = 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27868", "l": "(R)-glycerate + alpha-D-mannose 6-phosphate => (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19600", "l": "H2O + L-arginine <=> L-citrulline + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655301", "l": "Activated FGFR2 mutants phosphorylate PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35162", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O <=> (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21780", "l": "A + cyclohexanone = AH2 + cyclohex-2-enone", "d": [], "t": []}, {"i": "EC:1.3.99.14", "l": "\"cyclohexanone dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58769", "l": "1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175976", "l": "TMT transfers CH3 from AdoMet to BME (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.571199156962493", "identifiers": [{"i": "GO:0061134", "l": "peptidase regulator activity", "d": ["Binds to and modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686430", "l": "MUS81 binds EME1, EME2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102660", "l": "caffeoyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity", "d": ["Catalysis of the reaction: caffeoylshikimate + coenzyme A = caffeoyl-CoA + shikimate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70592", "l": "PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46708", "l": "2-hydroxybenzoyl-5'-AMP + holo-[ACP] = AMP + H(+) + salicyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42856", "l": "1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.53", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23353", "l": "2-oxoglutarate + 4-aminobutanoate => L-glutamate + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112514", "l": "JAK activation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19112", "l": "1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose <=> 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12647", "l": "(indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874082", "l": "MET phosphorylates PTK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49819", "l": "3 Fe(III)-[cytochrome c] + H2O + hydrazine <=> 3 Fe(II)-[cytochrome c] + 2 H(+) + NH4(+) + nitric oxide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-996727", "l": "REST recruits the BHC complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46814", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0061604", "l": "molybdopterin-synthase sulfurtransferase activity", "d": ["Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine = AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35109", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+) => 3-nitrotyramine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16372", "l": "(R)-lactate + NAD(+) <=> H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40525", "l": "a quinol + fumarate => a quinone + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38368", "l": "8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA => 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993790", "l": "Transfer of SUMO2 from E1 to UBE2I (UBC9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17944", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate <=> 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034545", "l": "fumarylpyruvate hydrolase activity", "d": ["Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138432", "l": "DVL2 is phosphorylated by PKC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44538", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56147", "l": "a quinol + nitrate <=> a quinone + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.34", "l": "\"6,7-dihydropteridine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22692", "l": "3-hydroxybenzoate + H(+) + NADH + O2 = 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.24", "l": "\"3-hydroxybenzoate 6-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58316", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9864415", "l": "AAC1 imports a proton (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47622", "l": "2-ethylhexanal + CO2 + H(+) + succinate + sulfate => 2-ethylhexyl sulfate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69438", "l": "7beta-hydroxypregnenolone + NADP(+) => 7-oxopregnenolone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16586", "l": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68945", "l": "esculetin + S-adenosyl-L-methionine => H(+) + isoscopoletin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696358", "l": "TREM,CD300 binds lipids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23495", "l": "UDP-alpha-D-glucosamine <=> UDP-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050599", "l": "deacetoxycephalosporin-C synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + O2 + penicillin N = CO2 + deacetoxycephalosporin C + H2O + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731924", "l": "EDNRA binds EDNs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54705", "l": "N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021480", "l": "NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35513", "l": "glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36602", "l": "hydrogen sulfide + NAD(+) <=> NADH + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018814", "l": "RHOT1 hydrolyzes GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9858590", "l": "DLST transfers glutaryl to CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59000", "l": "H2O + O2 + propanal = H(+) + H2O2 + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27424", "l": "(2E,6E)-farnesyl diphosphate <=> (3E,6E)-alpha-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672980", "l": "Dissociation of RAS:RAF complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70617", "l": "H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein] => hexadecanoyl-[ACP] + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74648", "l": "GTP + N-acetyl-D-glucosamine => GDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976801", "l": "Complement factor I complex formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655834", "l": "SREBP1A,1C,2:SCAP translocates to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61712", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine = 2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72318", "l": "glutathione(in) + leukotriene C4(out) <=> glutathione(out) + leukotriene C4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65708", "l": "alpha-D-mannose 1-phosphate + GDP-beta-L-galactose = beta-L-galactose 1-phosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60314", "l": "H(+) + N(6)-methyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45538", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine => H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65203", "l": "S-(acetaldehyde)-L-cysteine <=> (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047363", "l": "triglucosylalkylacylglycerol sulfotransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948651", "l": "miR-106a,(miR106b) microRNA binds CNOT6L mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39463", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA = (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047408", "l": "alkenylglycerophosphocholine hydrolase activity", "d": ["Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25353", "l": "H(+) + L-cysteine + tRNA(Pro) => H2O + L-cysteinyl-tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62735", "l": "(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) <=> (+)-isomalbrancheamide D + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350058", "l": "Formation of CSL NCOR corepressor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78553", "l": "Li(+)(out) => Li(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12557", "l": "6-phospho-D-glucono-1,5-lactone + H2O => 6-phospho-D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177942", "l": "EGFR binds EGF ligand (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76753", "l": "delta-dodecalactone + H2O => 5-hydroxydodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40860", "l": "(9Z)-hexadecenoyl-CoA + FAD + H(+) => (2E,9Z)-hexadecadienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0032029", "l": "myosin tail binding", "d": ["Binding to the tail region of a myosin heavy chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25471", "l": "(2E,6E)-farnesyl diphosphate <=> beta-himachalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32782", "l": "ATP + Co(2+)(out) + H2O <=> ADP + Co(2+)(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782879", "l": "TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50647", "l": "2-(3-methylsulfanyl)propylmalate <=> 3-(3-methylsulfanyl)propylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002083", "l": "4-hydroxybenzoate decaprenyltransferase activity", "d": ["Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44443", "l": "a 1,3-diacylglycerol + a 1-acylglycerol <=> a triacylglycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419428", "l": "S1PR2-5 bind S1P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624668", "l": "CEBPA binds CDKN1A (p21) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16289", "l": "(1R,2S)-ephedrine + NAD(+) = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.5.1.18", "l": "\"(-)-ephedrine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75002", "l": "deoxyerythrostominol(in) <=> deoxyerythrostominol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821368", "l": "AKAP8L binds MLL1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10754", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate => [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15458", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) => catechol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73358", "l": "beta-alanyl-[peptidyl-carrier protein] + histamine <=> carcinine + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.38", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3209165", "l": "ID1 sequesters ETS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55469", "l": "11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] => 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55142", "l": "AMP + D-alanyl-[D-alanyl-carrier protein] + H(+) => D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183126", "l": "Factor B binds to surface-associated C3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44696", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102742", "l": "R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity", "d": ["Catalysis of the reaction: H+ + 3,4-dihydroxyphenylpyruvate + NADPH = (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.50", "l": "\"lysyl endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68850", "l": "diphosphate + gamma-cadinene => (2Z,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21144", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}, {"i": "EC:1.5.98.2", "l": "\"5,10-methylenetetrahydromethanopterin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66801", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62154", "l": "dGDP + dTDP => dGMP + dTTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76598", "l": "a dicarboxylate(in) + sulfate(out) <=> a dicarboxylate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.15", "l": "\"(S)-2-hydroxy-acid oxidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043910", "l": "ATP:coenzyme F420 adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + factor gamma-F420-2 + H+ = coenzyme F390-A + diphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799416", "l": "TP53 stimulates expression of TP53INP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23877", "l": "protoaphin aglucone => H2O + xanthoaphin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21021", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate => chorismate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17963", "l": "H2O + leukotriene A4 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0016655", "l": "oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule."], "t": []}, {"i": "EC:1.6.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55816", "l": "a bacteriochlorophyllide d + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21418", "l": "dihydroxyacetone phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36740", "l": "heptadecasphing-4-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42403", "l": "lactose(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + lactose 6-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11053", "l": "4-aminobenzoate + 2 H(+) + NADH + O2 => 4-aminophenol + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168136", "l": "Activated JNKs phosphorylate c-JUN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70254", "l": "beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11967", "l": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O <=> 5alpha-cholestane-3beta,5,6beta-triol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72154", "l": "estrone 3-sulfate(out) + glutarate(in) <=> estrone 3-sulfate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707683", "l": "PGRMC2 binds Hemes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45681", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) => N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23981", "l": "cyclomaltodextrin + H2O => linear maltodextrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34761", "l": "ADP + glycerol 2-phosphate(in) + H(+) + phosphate => ATP + glycerol 2-phosphate(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47360", "l": "decanoate ester + H2O = an aliphatic alcohol + decanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47845", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) => CO2 + diphosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18769", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate = 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate", "d": [], "t": []}, {"i": "EC:5.3.2.5", "l": "\"2,3-diketo-5-methylthiopentyl-1-phosphate enolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23871", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA <=> acetyl-CoA + cyclohexanone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42194", "l": "(9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47660", "l": "acetyl-CoA + L-methionine sulfoximine = CoA + H(+) + N-acetyl-L-methionine sulfoximine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59512", "l": "acetylsalicylate + L-seryl-[protein] = O-acetyl-L-seryl-[protein] + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44757", "l": "2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13728", "l": "acetyl-CoA + alpha-D-glucosamine 1-phosphate <=> CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381109", "l": "IRE1 binds IRE1 forming dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20280", "l": "acetyl-CoA + an N-hydroxyarylamine <=> an N-acetoxyarylamine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43665", "l": "ATP + hydrogencarbonate + tetracosanoyl-CoA => 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047856", "l": "dihydrocoumarin hydrolase activity", "d": ["Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.22", "l": "\"vitamin D 1,25-hydroxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10775", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O <=> D-glucose + D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070694", "l": "deoxyribonucleoside 5'-monophosphate N-glycosidase activity", "d": ["Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base."], "t": []}, {"i": "REACT:R-HSA-8953339", "l": "DNPH1 hydrolyses dGMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55613", "l": "an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O => 1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9865350", "l": "Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54044", "l": "(2E,6E)-farnesyl diphosphate + H2O = 7-epi-alpha-eudesmol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.169", "l": "\"7-epi-alpha-eudesmol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33235", "l": "2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 = 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.81", "l": "\"magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9846477", "l": "A4GALT transfers galactose to LacCer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873917", "l": "Translocation of STAT1 dimer to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38358", "l": "(R)-3-phenyllactoyl-CoA <=> (E)-cinnamoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41969", "l": "a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21111", "l": "(S)-3-methyl-2-oxopentanoate + H(+) <=> 2-methylbutanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62116", "l": "H2O + iminosuccinate = NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24309", "l": "25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036185", "l": "13-lipoxin reductase activity", "d": ["Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+."], "t": []}, {"i": "REACT:R-HSA-2161844", "l": "15k-LXA4 is reduced to dhk-LXA4 by PTGR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45092", "l": "H2O + N-octanoylsphing-4-enine = octanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004925", "l": "prolactin receptor activity", "d": ["Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141367", "l": "Myristoylation of tBID by NMT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839072", "l": "HTRA2 degrades APP (Amyloid-beta precursor protein) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39251", "l": "(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH = (11Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632668", "l": "SMO translocates to the cilium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39297", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35472", "l": "(+)-6a-hydroxymaackiain + S-adenosyl-L-methionine => (+)-pisatin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14849", "l": "H2O + N-amidino-L-aspartate = L-aspartate + urea", "d": [], "t": []}, {"i": "EC:3.5.3.14", "l": "\"amidinoaspartase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683687", "l": "Nucleoprotein is SUMOylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52633", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP => [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692755", "l": "CDK1 phosphorylates MAPK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70129", "l": "3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358545", "l": "EXO1 interacts with MSH2:MSH3 (MutSbeta) and MLH1:PMS2 (MutLalpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20077", "l": "guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.34", "l": "\"tRNA (guanosine(18)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73800", "l": "SAICAR => AICAR + Fumarate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75357", "l": "3-hydroxy-4H-pyrid-4-one + NH4(+) + pyruvate => H2O + L-mimosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38789", "l": "(9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19740", "l": "4-(gamma-L-glutamylamino)butanoate + H2O <=> 4-aminobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828209", "l": "OPTN binds TBK1 within the activated TLR3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29151", "l": "3 a ubiquinol(in) + 2 H(+)(out) + nitrite(out) = 3 a ubiquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9695890", "l": "SPNS2,MFSD2B transport S1P from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.78", "l": "\"GPR endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088338", "l": "Defective GNE does not hydrolyse UDP-GlcNAc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610723", "l": "GLI proteins bind SUFU (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25712", "l": "L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051909", "l": "acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate", "d": ["Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50546", "l": "prostaglandin B2 => prostaglandin C2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983150", "l": "Proteasomal cleavage of substrate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.38", "l": "\"FMN reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55042", "l": "3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP] => (9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17398", "l": "a (3R)-hydroxyacyl-[ACP] + NADP(+) => a 3-oxoacyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30266", "l": "H2O2 + 2 L-ascorbate <=> 2 H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036141", "l": "L-phenylalanine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction L-phenylalanine + oxaloacetate = phenylpyruvate + aspartate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696323", "l": "CNRs bind CNR agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71584", "l": "L-histidine(in) + Na(+)(in) => L-histidine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047058", "l": "vitamin-K-epoxide reductase (warfarin-insensitive) activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9855910", "l": "USF1 is phosphorylated by p-MAPK14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3221982", "l": "BANP binds TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392195", "l": "Gi activation by P2Y purinoceptor 12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451758", "l": "p85 associates with both p-Nephrin and CD2AP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801675", "l": "PLK2 phosphorylates NPM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19566", "l": "(2E)-geranyl diphosphate + H2O => diphosphate + sabinene hydrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418091", "l": "F2R binds ARRB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30208", "l": "H2O + methylamine + 2 oxidized [amicyanin] => formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692376", "l": "BCL2 binds BCL2 antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60339", "l": "N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005001", "l": "transmembrane receptor protein tyrosine phosphatase activity", "d": ["Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140586", "l": "promoter-terminator loop anchoring activity", "d": ["Bridging together a cis-regulatory element and a terminator DNA sequences on the chromatin, holding two loop anchors together, maintaining a chromatin loop."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37898", "l": "H2O + protodioscin <=> 26-deglucoprotodioscin + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004530", "l": "deoxyribonuclease I activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209828", "l": "Tryptophan is hydroxylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682563", "l": "nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78220", "l": "D-arginine + H2O + O2 => 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66539", "l": "A + cholest-4,6-dien-3-one + H2O <=> 25-hydroxycholest-4,6-dien-3-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76071", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008668", "l": "2,3-dihydroxybenzoate--[aryl-carrier protein] ligase", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP + holo-[ACP] = 2,3-dihydroxybenzoyl-[ACP] + AMP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050234", "l": "pyrazolylalanine synthase activity", "d": ["Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44535", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59623", "l": "H2O + N(2)-(4-aminobutanoyl)-L-lysine <=> 4-aminobutanoate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419351", "l": "PAF receptor binds platelet activating factor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10460", "l": "prostaglandin A1 = prostaglandin C1", "d": [], "t": []}, {"i": "EC:5.3.3.9", "l": "\"prostaglandin-A1 Delta-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64510", "l": "2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine => acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61216", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45578", "l": "(2S)-methylsuccinyl-CoA => (2R)-ethylmalonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78189", "l": "a 1-acyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43148", "l": "adenosine(9) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.218", "l": "\"tRNA (adenine(9)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21710", "l": "adenosine + L-homocysteine => H2O + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12503", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65795", "l": "fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35363", "l": "(2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH = isopentadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48286", "l": "a globoside NOR1 (d18:1(4E)) + H(+) + UDP => a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43388", "l": "1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854052", "l": "Formation of the SCF-FBXL7 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74868", "l": "(E)-caffeyl aldehyde + CoA + NADP(+) => (E)-caffeoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54659", "l": "linalool <=> (2E)-geraniol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19152", "l": "L-arginyl-[protein] + NAD(+) <=> H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29857", "l": "D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate => H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112435", "l": "Formation of Elongin BC complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42662", "l": "H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose => NAD(+) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11846", "l": "CoA + pyruvate => acetyl-CoA + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47790", "l": "a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in 28S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30298", "l": "GTP + pyruvate <=> GDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229132", "l": "AP4 binds APP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39003", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-196026", "l": "Dab2 is recruited to the junctional plaques (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77751", "l": "(2E,10E)-dode-2,10-dicenoyl-CoA + H2O + oxaloacetate = (4E,11E)-2-hydroxytrideca-4,11-dien-1,2,3-tricarboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428273", "l": "SPHK1 phosphorylates sphingoid (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31449", "l": "5-aminopentanoate + CO2 + H2O => 6-amino-2-oxohexanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20906", "l": "(S)-1,2-epoxypropane + coenzyme M => (S)-2-hydroxypropyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61351", "l": "ATP + estrone 3-sulfate(in) + H2O <=> ADP + estrone 3-sulfate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76562", "l": "1-(ergostan-3beta-yl)-L-aspartate + H2O <=> ergosterol + H(+) + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23838", "l": "4-methylsulfanyl-2-oxobutanoate + L-alanine => D-methionine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0023023", "l": "MHC protein complex binding", "d": ["Binding to a major histocompatibility complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55230", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29037", "l": "ADP + H(+) + L-glutamate(in) + phosphate => ATP + H2O + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831152", "l": "SH pentamer localizes to host cell plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72103", "l": "Formation of pre-mRNPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0030305", "l": "heparanase activity", "d": ["Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains."], "t": []}, {"i": "REACT:R-HSA-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047967", "l": "glycyrrhizinate beta-glucuronidase activity", "d": ["Catalysis of the reaction: glycyrrhizate + H2O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36279", "l": "H(+) + NADH + O2 + theophylline = 3-methylxanthine + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31853", "l": "parkeol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784861", "l": "HSPG binds LPL dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418904", "l": "A1 and A3 receptors bind adenosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20633", "l": "a (3R)-hydroxyacyl-[ACP] + L-ornithine = a lyso-ornithine lipid + H(+) + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.2.30", "l": "\"L-ornithine N(alpha)-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10223", "l": "ATP + L-tyrosine + tRNA(Tyr) <=> AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63966", "l": "(2E,12Z)-hexadecadienal + phosphoethanolamine => sphinga-4E,14Z-dienine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9656244", "l": "DRD2 binds DA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66444", "l": "hexan-3-one + NADP(+) = (E)-4-hexen-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070733", "l": "AMPylase activity", "d": ["Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to L-serine, L-threonine, and L-tyrosine residues in target proteins."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74025", "l": "L-alanine(out) + L-serine(in) => L-alanine(in) + L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76243", "l": "a glycyl-glycyl-[protein] + H2O = [protein]-C-terminal glycine + N-terminal glycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68885", "l": "3-hydroxybenzoate + ATP + H(+) + NADPH => 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101021", "l": "estrogen 2-hydroxylase activity", "d": ["Catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9842648", "l": "Autophosphorylation of LTK dimer:ALKAL1,2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.6", "l": "\"ABC-type oligopeptide transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64847", "l": "(2E)-geraniol + benzoyl-CoA <=> (2E)-geranyl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481044", "l": "Surface deployment of platelet alpha granule membrane components (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602473", "l": "Autocatalytic activation of MMP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019768", "l": "high-affinity IgE receptor activity", "d": ["Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32051", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate = adenosine 5'-tetraphosphate + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0001098", "l": "basal transcription machinery binding", "d": ["Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682388", "l": "Autophagosome maturation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77223", "l": "gentamicin X2 + methylcob(III)alamin + S-adenosyl-L-methionine = 5'-deoxyadenosine + cob(III)alamin + geneticin + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10468", "l": "D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O", "d": [], "t": []}, {"i": "EC:4.1.2.9", "l": "\"phosphoketolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25316", "l": "2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate => L-2-acetamido-6-oxoheptanedioate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68705", "l": "3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate) => 3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19457", "l": "2-nitrophenol + 2 H(+) + 2 NADPH + O2 = catechol + H2O + 2 NADP(+) + nitrite", "d": [], "t": []}, {"i": "EC:1.14.13.31", "l": "\"2-nitrophenol 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5251942", "l": "Hikeshi binds HSP70s:ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848939", "l": "PTK6 binds KHDRBS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65875", "l": "1,17beta-dihydroxyandrostan-3-one + A <=> 17beta-hydroxyandrostan-1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130194", "l": "ABL phosphorylates WAVEs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0001228", "l": "DNA-binding transcription activator activity, RNA polymerase II-specific", "d": ["A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8980691", "l": "RHOA GEFs activate RHOA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21173", "l": "L-idonate + NAD(+) => 5-dehydro-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70573", "l": "argininosuccinate <=> fumarate + arginine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050143", "l": "nocardicin-A epimerase activity", "d": ["Catalysis of the reaction: isonocardicin A = nocardicin A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57246", "l": "dGTP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671702", "l": "AP1G2 binds HGS and CHMP2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709842", "l": "MAVS binds TOMM70 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16324", "l": "(S)-indan-1-ol + NADP(+) <=> H(+) + indan-1-one + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507875", "l": "Aquaporins passively transport urea into cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40079", "l": "docosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77264", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine(in) => beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9825759", "l": "MAPK-dependent phosphorylation of KARS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63434", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) => 1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32913", "l": "sn-glycerol 3-phosphocholine(in) => sn-glycerol 3-phosphocholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374337", "l": "Apelin receptor binds to apelin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789092", "l": "NOX2 generates superoxide anion from oxygen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835944", "l": "ADAR1 binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64939", "l": "dGTP + H2O <=> dGDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46414", "l": "a (7Z,10Z,13Z)-hexadecatrienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (7Z,10Z)-hexadecadienoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015539", "l": "hexuronate:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59662", "l": "D-cellotetraono-1,5-lactone + H2O2 => D-cellotetraose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51624", "l": "formate + GTP + H(+) = CO2 + dGTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432188", "l": "AVP:AVPR2 Complex binds inactive heterotrimeric G(s) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805285", "l": "PLK3 phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58168", "l": "(2E,6E)-farnesyl diphosphate = (-)-5-epi-eremophilene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.199", "l": "\"(-)-5-epieremophilene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10769", "l": "(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 => (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23713", "l": "NADP(+) + pregnan-21-ol => H(+) + NADPH + pregnan-21-al", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71000", "l": "(S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332363", "l": "Autophosphorylation and activation of CAMK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205231", "l": "Dimerization of KIT upon SCF binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102588", "l": "cyanidin 3-O-glucoside 6''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + malonyl-CoA = cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59369", "l": "1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.57", "l": "\"leucyl endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47962", "l": "L-histidyl-[protein] + phosphate => H2O + N(tele)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0005509", "l": "calcium ion binding", "d": ["Binding to a calcium ion (Ca2+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68618", "l": "cortisol + NADP(+) => cortisone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20002", "l": "glycolaldehyde + H2O + NAD(+) => glycolate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65628", "l": "sphinga-(4E,8Z)-dienine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinga-(4E,8Z)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6802973", "l": "PLK3 phosphorylates CDC25C (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450422", "l": "KSRP recruits RNA degradation activities (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1299318", "l": "Activation of TASK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675921", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41742", "l": "2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine => adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68461", "l": "3'-phosphoadenylyl sulfate + a phenolic steroid => a phenolic steroid 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78708", "l": "H2O + N-terminal L-arginyl-L-amino acid-[protein] => an N-terminal L-alpha-aminoacyl-[protein] + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14133", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.103", "l": "\"tabersonine 16-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399930", "l": "Activation of PAK by Rac1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67314", "l": "myceliothermophin E => (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71704", "l": "taurocholate(out) => taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9008043", "l": "MAPK8 phosphorylation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40829", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12667", "l": "an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+) => a 2-deoxystreptamine antibiotic + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63696", "l": "SN-38 + UDP-alpha-D-glucuronate = H(+) + SN-38 O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870466", "l": "RGGT:CHM binds RABs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22694", "l": "2,5-dihydroxybenzoate + H2O + NAD(+) => 3-hydroxybenzoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204500", "l": "CyP60 chaperones Basigin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25220", "l": "acetyl-CoA + serotonin <=> CoA + H(+) + N-acetylserotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:1901513", "l": "lipo-chitin oligosaccharide transmembrane transporter activity", "d": ["Enables the transfer of lipo-chitin oligosaccharide from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74350", "l": "O-acyl-(R)-carnitine(in) <=> O-acyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33044", "l": "(1R,4R)-camphor + H(+) + NADPH + O2 => (+)-6-exo-hydroxycamphor + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49062", "l": "a long chain fatty alcohol + FMN + H(+) + H2O => a long-chain alkane + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41868", "l": "decanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16262", "l": "L-lysyl-[protein] + succinyl-CoA => CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102541", "l": "D-galactose 6-phosphate 1-epimerase activity", "d": ["Catalysis of the reaction: alpha-D-galactose 6-phosphate = beta-D-galactose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043897", "l": "glucan 1,4-alpha-maltohydrolase activity", "d": ["Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51018", "l": "6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate => 7,8-dihydroneopterin 3'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9864415", "l": "AAC1 imports a proton (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33187", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51997", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase] => a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975853", "l": "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44595", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840488", "l": "PSAP(195-273) forms a dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982807", "l": "JAK2 phosphorylation of GHR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40283", "l": "(R)-carnitine + hexadecanedioyl-CoA = CoA + O-hexadecanedioyl-L-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72552", "l": "glutarate(out) + urate(in) => glutarate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71726", "l": "H(+)(out) + L-alanyl-L-leucyl-L-alanine(out) <=> H(+)(in) + L-alanyl-L-leucyl-L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177926", "l": "Dephosphorylation of PAG by SHP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68296", "l": "dodecanoyl-CoA + L-seryl-[protein] = CoA + O-dodecanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8986480", "l": "IL26:IL20RA:JAK1 binds IL10RB:TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15534", "l": "(2R)-3-sulfolactate + NAD(+) => 3-sulfopyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64078", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+) => 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051267", "l": "CP2 mannose-ethanolamine phosphotransferase activity", "d": ["Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-phosphate-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690152", "l": "USP5 cleaves polyubiquitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45583", "l": "D-galactaro-1,5-lactone <=> D-galactaro-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59601", "l": "5-methoxytryptamine + H2O + O2 => 5-methoxyindoleacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31815", "l": "(2E,6E)-farnesyl diphosphate = (+)-(E)-beta-caryophyllene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.89", "l": "\"(+)-beta-caryophyllene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848335", "l": "IL37 binds  IL18R1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29272", "l": "a menaquinol + H(+) + trimethylamine N-oxide => a menaquinone + H2O + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67046", "l": "AH2 + chermesin D => A + asnovolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12146", "l": "cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP => cyanidin 3-O-rutinoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23901", "l": "cis-stilbene oxide + H2O => (1R,2R)-hydrobenzoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14416", "l": "biphenyl-2,3-diol + O2 <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65155", "l": "(2S)-naringenin + UDP-alpha-D-glucose <=> (2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66451", "l": "(E)-pent-2-en-1-ol + NADP(+) <=> (E)-2-pentenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156678", "l": "Activation of Cdc25C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983152", "l": "Transfer of ubiquitin from E1 to E2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953556", "l": "E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47348", "l": "a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65577", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate => an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42530", "l": "pseudouridine(955/2504/2580) in 23S rRNA => uridine(955/2504/2580) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19245", "l": "N-phenylhydroxylamine = 2-aminophenol", "d": [], "t": []}, {"i": "EC:5.4.4.1", "l": "\"(hydroxyamino)benzene mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873919", "l": "Phosphorylation of JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39291", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174967", "l": "NAT2 acetylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27280", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73408", "l": "(S,S)-tartrate(in) + sulfate(out) => (S,S)-tartrate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61751", "l": "rubusoside + UDP-alpha-D-glucose <=> H(+) + stevioside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.43", "l": "\"lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032427", "l": "GBD domain binding", "d": ["Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52587", "l": "chenodeoxycholoyl-CoA + NAD(+) <=> 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14371", "l": "glycolate + phosphate => 2-phosphoglycolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18987", "l": "isochorismate => chorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22605", "l": "D-mannose => D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63486", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein] => 2-oxoglutarate + L-prolyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27944", "l": "NH4(+) + oxaloacetate => (3R)-3-hydroxy-D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12674", "l": "an aliphatic amide => a nitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39491", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22810", "l": "2,6-dihydroxynicotinate + H2O2 => 6-hydroxynicotinate + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.-", "l": "\"Acting on GTP; involved in cellular and subcellular movement\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350651", "l": "Caspase-mediated cleavage of MASK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66300", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose = an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.-", "l": "\"With H2O2 as acceptor, one oxygen atom of which is incorporated into the product\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69468", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose = L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": [], "t": []}, {"i": "EC:2.6.1.122", "l": "\"UDP-N-acetyl-3-dehydro-alpha-D-glucosamine 3-aminotranferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2399913", "l": "atRAL binds to RBP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3076905", "l": "Extracellular BTD hydrolyses BCTN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873929", "l": "Casein kinase II phosphorylates STARD10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23135", "l": "3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] <=> 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189406", "l": "4 PBGs bind to form HMB (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607746", "l": "PKC-delta is activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11602", "l": "ADP + CDP => ATP + CMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10647", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H2O <=> (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59206", "l": "AMP + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + H(+) => docosanoyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009927", "l": "histidine phosphotransfer kinase activity", "d": ["Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694436", "l": "MIA2 and MIA3 dissociate from procollagen VII vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76611", "l": "H(+) + NADPH + vanillin = 4-hydroxy-3-methoxy-benzenemethanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198669", "l": "p38MAPK phosphorylates MSK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70853", "l": "H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in) => H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047388", "l": "[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase activity", "d": ["Catalysis of the reaction: [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52392", "l": "ATP + D-erythronate = 4-phospho-D-erythronate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.220", "l": "\"D-erythronate 4-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9859148", "l": "BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31226", "l": "cis-beta-D-glucosyl-2-hydroxycinnamate + H2O <=> beta-D-glucose + cis-2-coumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.14", "l": "\"methyl-branched lipid omega-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21147", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45430", "l": "H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785607", "l": "FANCM binds FAAP24 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53894", "l": "a prenal + H2O2 + L-cysteine => an S-prenyl-L-cysteine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57279", "l": "a 2'-deoxyguanosine in DNA + glyoxal <=> an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42903", "l": "guanosine(745) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47467", "l": "(3E,5Z)-tetradecadienoyl-CoA <=> (2E,5Z)-tetradecadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854052", "l": "Formation of the SCF-FBXL7 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36426", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34673", "l": "3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67989", "l": "N-acetyl-L-glutamine => N-acetyl-D-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28708", "l": "Cd(2+)(in) => Cd(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49586", "l": "L-erythrulose 1-phosphate => D-erythrulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15805", "l": "(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.3.3", "l": "\"dethiobiotin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22547", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O <=> a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42489", "l": "(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III => 3'-N-debenzoyl-2'-deoxytaxol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72733", "l": "UDP-alpha-D-glucose(out) + UMP(in) => UDP-alpha-D-glucose(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34052", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H2O => 6'''-deamino-6'''-hydroxyneomycin C + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5227009", "l": "ABCF1 binds EIF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12323", "l": "17-O-acetylnorajmaline + NADP(+) <=> 1,2-dihydrovomilenine + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0008726", "l": "alkanesulfonate monooxygenase activity", "d": ["Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139906", "l": "Activation of BAD by calcineurin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19735", "l": "bacteriochlorophyllide a + H(+) + NADH => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10656", "l": "guanidinoacetate + S-adenosyl-L-methionine = creatine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.2", "l": "\"guanidinoacetate N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76863", "l": "benzylamine + H2O + NAD(+) = benzaldehyde + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419861", "l": "Melanospin is stimulated by light (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32294", "l": "phosphoethanolamine + 3 S-adenosyl-L-methionine <=> 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59995", "l": "H(+) + oxidized [electron-transfer flavoprotein] + phloretate <=> (E)-4-coumarate + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008738", "l": "L-fuculose-phosphate aldolase activity", "d": ["Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9866272", "l": "2Fe-2S is inserted in UQCRFS1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682020", "l": "MRN complex binds shortened telomeres (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20248", "l": "ATP + streptomycin <=> 3''-O-adenylylstreptomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001729", "l": "ceramide kinase activity", "d": ["Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31688", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39867", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol = 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61746", "l": "stevioside + UDP => steviolbioside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71534", "l": "guanine(out) <=> guanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46096", "l": "3-phenylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO2 + 4 CoA + dihydropinosylvin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67347", "l": "kaempferol 7-O-beta-D-glucoside + malonyl-CoA <=> CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399930", "l": "Activation of PAK by Rac1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9834821", "l": "p-PRKRA dimer binds PKR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38152", "l": "carbonyl sulfide + H2O => CO2 + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44390", "l": "1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18434", "l": "cyclohexylamine + H2O + O2 => cyclohexanone + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31892", "l": "2-hydroxy-1-phenyl-1-propanone + NADP(+) => 1-phenyl-1,2-propanedione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73571", "l": "(E,E)-piperate + ATP + CoA = (E,E)-piperoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030623", "l": "U5 snRNA binding", "d": ["Binding to a U5 small nuclear RNA (U5 snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.118", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31151", "l": "H2O + L-selenocystathionine = 2-oxobutanoate + L-selenocysteine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56518", "l": "2 CO2 + 4 H2O + heme b => Fe-coproporphyrin III + 2 H(+) + 2 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43591", "l": "a globoside NORint + UDP-alpha-D-galactose <=> a globoside NOR2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55035", "l": "an N-methylornithine lipid + S-adenosyl-L-methionine <=> an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623519", "l": "RAB3IP and RAB8A bind to the ciliary targeting complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16912", "l": "2 Fe(III)-[cytochrome c] + glycine + H2O <=> 2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.339", "l": "\"dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18128", "l": "A + a D-alpha-amino acid + H2O <=> a 2-oxocarboxylate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008773", "l": "[protein-PII] uridylyltransferase activity", "d": ["Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72299", "l": "3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) = 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40996", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA => 4-hydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39036", "l": "an omega-hydroxy fatty acid + NAD(+) => an omega-oxo fatty acid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654167", "l": "Activated FGFR1 binds PLCG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46032", "l": "H2O2 + tetradecanoate = (2S)-hydroxytetradecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24729", "l": "N-demethylindolmycin + S-adenosyl-L-methionine <=> H(+) + indolmycin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78924", "l": "a short-chain (3S)-3-hydroxyacyl-CoA + NAD(+) => a short-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878117", "l": "RUNX3 binds ZFHX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37678", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362386", "l": "Glycosylation of Hh (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179410", "l": "Association of Nek2A with MCC:APC/C (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936851", "l": "AHRR binds ARNT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30969", "l": "9,9'-di-cis-zeta-carotene => 9,9',15-tri-cis-zeta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564117", "l": "Collagen type XIV degradation by MMP9,13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24329", "l": "7,8-dihydrofolate + ATP + formate => 10-formyldihydrofolate + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909724", "l": "Recruitment of IFNAR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707856", "l": "PGRMC2:Hemes dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68223", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol <=> (7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45235", "l": "a (2E,4Z)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648268", "l": "HTR1A binds HTR1A antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43087", "l": "cytidine(34) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44473", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24401", "l": "ATP + UMP => ADP + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433986", "l": "activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the  phospho-IkB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21944", "l": "ATP + D-cellobiose = 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.85", "l": "\"beta-glucoside kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57388", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.167", "l": "\"(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17785", "l": "H(+) + L-glutamate = 4-aminobutanoate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.15", "l": "\"glutamate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32540", "l": "(2E)-geranyl diphosphate => (+)-car-3-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050586", "l": "3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methylquinolin-4(1H)-one + H+ + O2 = N-acetylanthranilate + CO."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296233", "l": "T2Rs bind bitter-tasting compounds (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848178", "l": "STAT3 stimulates SOCS3 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791155", "l": "Laminin-322 degradation by MMP14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392195", "l": "Gi activation by P2Y purinoceptor 12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417927", "l": "P2Y2 receptor binds ATP and UTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416562", "l": "p190RhoGAP binds Plexin-B1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429767", "l": "Passive I- efflux mediated by SLC5A8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75733", "l": "10-oxo-(12Z)-octadecenoate + H(+) + NADH => (10S)-hydroxy-(12Z)-octadecenoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53814", "l": "(25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin] => cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61997", "l": "L-lysyl-[protein] + lactoyl-CoA => CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18123", "l": "a thiol + NH4(+) + pyruvate => an S-substituted L-cysteine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202604", "l": "Formation of a heteromeric BMP receptor complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76046", "l": "(S)-cis-N-methyltetrahydropalmatine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + muramine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15773", "l": "ATP + dihydroxyacetone = ADP + dihydroxyacetone phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.29", "l": "\"glycerone kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68622", "l": "20beta-dihydrocortisone + NADP(+) => cortisone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.74", "l": "\"chalcone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033929", "l": "blood-group-substance endo-1,4-beta-galactosidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in blood group A and B substances."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74415", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655850", "l": "Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47550", "l": "3-oxochola-4,6-dien-24-oate + H2O => 7alpha-hydroxy-3-oxochol-4-en-24-oate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703436", "l": "STAT5-dependent PIM1 gene expression downstream of FLT3 ITD and fusion mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18175", "l": "(4-hydroxyphenyl)acetaldehyde + NH4(+) => (R)-octopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.616479785166973", "identifiers": [{"i": "GO:0140297", "l": "DNA-binding transcription factor binding", "d": ["Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61212", "l": "myricetin + UDP-alpha-D-glucose = H(+) + myricetin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58740", "l": "H2O + psi-UTP = diphosphate + H(+) + psi-UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164832", "l": "ATPase synthesizes ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818495", "l": "UHRF1:DPPA3 translocates from the nucleoplasm to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25832", "l": "1D-chiro-inositol + NAD(+) = H(+) + NADH + scyllo-inosine", "d": [], "t": []}, {"i": "EC:1.1.1.369", "l": "\"D-chiro-inositol 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0032356", "l": "oxidized DNA binding", "d": ["Binding to a DNA region containing an oxidized residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56052", "l": "2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}, {"i": "EC:3.2.1.114", "l": "\"mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71909", "l": "H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide => GDP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67304", "l": "3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 = H2O2 + myceliothermophin E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015390", "l": "purine-specific nucleoside:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874080", "l": "SRC phosphorylates PTK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68539", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-cedrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44503", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51913", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983707", "l": "SYK autophosphorylates at the activated BCR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29426", "l": "ATP + diphosphate <=> ADP + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35787", "l": "paromamine + UDP-alpha-D-kanosamine = H(+) + kanamycin C + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66497", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19055", "l": "H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6799350", "l": "Exocytosis of specific granule membrane proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22702", "l": "gibberellin A12 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => gibberellin A12 aldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38456", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088306", "l": "FOXM1 binds PLK1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53479", "l": "1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16712", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2993802", "l": "HLCS biotinylates PC:Mn2+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57547", "l": "(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874718", "l": "TTPA binds alpha-TOH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140927", "l": "cyclic-di-GMP transmembrane transporter activity", "d": ["Enables the transfer of cyclic-di-GMP from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046978", "l": "TAP1 binding", "d": ["Binding to the TAP1 subunit of TAP (transporter associated with antigen processing) protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018702", "l": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity", "d": ["Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102354", "l": "11-cis-retinol dehydrogenase activity", "d": ["Catalysis of the reaction: 11-cis-retinol + NADP = 11-cis-retinal + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77200", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxy-5-cholenate => 3beta-sulfo-5-cholenate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68393", "l": "H2O + peracetic acid => acetate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033509", "l": "USP9X binds Ub:PEX5L (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39301", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+) => (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41803", "l": "acetyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867344", "l": "OMA1 hydrolyses OPA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244605", "l": "TREX1 binds retroviral-derived DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640862", "l": "Tankyrase binds AXIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213244", "l": "Loading of antigenic peptides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31128", "l": "3-O-methylgallate + O2 => 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27986", "l": "hydroxyacetone + NADP(+) = H(+) + methylglyoxal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.67", "l": "\"choriolysin H\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64427", "l": "H(+)(out) + L-leucyl-L-proline(out) <=> H(+)(in) + L-leucyl-L-proline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78997", "l": "a 4-carboxy-3-alkylbut-(2E)-enoyl-[ACP] + H2O => a 3-carboxymethyl-3-hydroxyacyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60692", "l": "(E)-non-2-enal + H2O + NADP(+) = (E)-non-2-enoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73738", "l": "O2 + trans-resveratrol <=> 3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685605", "l": "SLAMF7 binds SLAMF7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10933", "l": "ATP + L-aspartate + L-citrulline => 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13038", "l": "ATP + H(+) + H2O => ITP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20555", "l": "(S)-methylmalonyl-CoA => (R)-methylmalonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47188", "l": "Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol = hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982617", "l": "CYGB:O2 dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78607", "l": "(3R)-hydroxyoctadecanoyl-CoA + NAD(+) = 3-oxooctadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396371", "l": "NOTCH1 Coactivator Complex binds MYC promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21348", "l": "8 H(+) + 10 malonyl-CoA = 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2", "d": [], "t": []}, {"i": "EC:2.3.1.235", "l": "\"tetracenomycin F2 synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58814", "l": "AMP + diphosphate + H(+) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ATP + H2O + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616243", "l": "CEBPA gene transcription is enhanced by RUNX1, SPI1 (PU.1), GATA2, TAL1 (SCL), FLI1, MYB, LEF1, and CEBPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23426", "l": "D-glucosamine 6-phosphate => alpha-D-glucosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78766", "l": "H2O + N-deacetylipecoside <=> D-glucose + N-deacetylipecoside aglycone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1564169", "l": "Collagen type VIII degradation by MMP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68610", "l": "Formation of ORC(2-5) complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32203", "l": "(R)-synephrine = (4-hydroxyphenyl)acetaldehyde + methylamine", "d": [], "t": []}, {"i": "EC:4.2.1.88", "l": "\"synephrine dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17551", "l": "1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine => 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2314686", "l": "ASA- acetylates PTGS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16417", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+) = H(+) + L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641134", "l": "SMURF2 binds AXIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14549", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + formate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.9", "l": "\"2-hydroxymuconate-6-semialdehyde hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75470", "l": "ethanolamine(out) + n H(+)(in) <=> ethanolamine(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19281", "l": "(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] = acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen", "d": [], "t": []}, {"i": "EC:1.14.14.141", "l": "\"psoralen synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140823", "l": "histone H2BS36 kinase activity", "d": ["Catalysis of the reaction: histone H2B-serine (position 36) + ATP = histone H2B-phosphoserine (position 36) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 36 of histone H2B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70320", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O => 1D-myo-inositol 3,4-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51721", "l": "ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72633", "l": "Ca(2+)(out) + 3 Li(+)(in) => Ca(2+)(in) + 3 Li(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40144", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O => (9Z,12Z)-octadecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67003", "l": "2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + phlorisobutanophenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61768", "l": "rebaudioside A + UDP-alpha-D-glucose = H(+) + rebaudioside D + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050447", "l": "zeatin 9-aminocarboxyethyltransferase activity", "d": ["Catalysis of the reaction: O-acetyl-L-serine + zeatin = L-lupinate + acetate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5226999", "l": "ADD1:ADD3 binds DMTN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19461", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27952", "l": "L-phenylalanine(out) => L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694522", "l": "Inner coat assembly and cargo binding (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38685", "l": "ADP + H(+) + phosphate + sphing-4-enine(out) => ATP + H2O + sphing-4-enine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59615", "l": "beta-alanyl-L-ornithine + H2O <=> beta-alanine + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163625", "l": "Glucagon binds to Glucagon receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40066", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O <=> 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48312", "l": "benzoyl-CoA + H(+) + NADPH + O2 = 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.208", "l": "\"benzoyl-CoA 2,3-epoxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37360", "l": "D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] => D-glucosamine 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40412", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20777", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose => myo-inositol + stachyose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39738", "l": "3-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9853499", "l": "DLD dimer dehydrogenates dihydrolipoyl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46698", "l": "an N(1)-methylpseudouridine in rRNA + H(+) + S-adenosyl-L-homocysteine => a pseudouridine in rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433501", "l": "Interaction of other adapter proteins with p-KIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16639", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64158", "l": "a fatty acid + L-methionine => an N-(fatty acyl)-L-methionine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983156", "l": "Polyubiquitination of substrate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19708", "l": "CoA + hexadecanal + NAD(+) <=> H(+) + hexadecanoyl-CoA + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045520", "l": "interleukin-24 receptor binding", "d": ["Binding to an interleukin-24 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43431", "l": "1,2-didecanoyl-sn-glycerol + ATP <=> 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16624", "l": "dihydrosanguinarine + H(+) + O2 <=> H2O2 + sanguinarine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14802", "l": "(2R)-3-phosphoglycerate + ATP => (2R)-3-phospho-glyceroyl phosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73071", "l": "apigenin + S-adenosyl-L-methionine = genkwanin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578777", "l": "DMPK phosphorylates PLN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60432", "l": "A + cannabigerolate = AH2 + cannabichromenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39674", "l": "(9Z)-hexadecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180021", "l": "U6 snRNA 2'-O-ribose methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + U6 snRNA = S-adenosyl-L-homocysteine + U6 containing a 3'-terminal 2'-O-methylnucleotide + H+."], "t": []}, {"i": "RHEA:63088", "l": "a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825615", "l": "Expression of RIPPLY2 in presomitic mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21553", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46508", "l": "NADH + nitrobenzene + O2 = catechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63061", "l": "5-methylorsellinate + ATP + H(+) + NADPH => 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23948", "l": "4-hydroxybutanoate + NAD(+) = H(+) + NADH + succinate semialdehyde", "d": [], "t": []}, {"i": "EC:1.1.1.61", "l": "\"4-hydroxybutyrate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.188221489317044", "identifiers": [{"i": "GO:0003872", "l": "6-phosphofructokinase activity", "d": ["Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2562526", "l": "PLK1 phosphorylates OPTN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21376", "l": "3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2", "d": [], "t": []}, {"i": "EC:1.13.11.46", "l": "\"4-hydroxymandelate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717841", "l": "holo-FDPS dimer binds NBPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27939", "l": "(3R)-3-hydroxy-D-aspartate => glycine + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71376", "l": "2 Na(+)(out) + testosterone 17-sulfate(out) => 2 Na(+)(in) + testosterone 17-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18845", "l": "(R)-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73978", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77308", "l": "N(omega),N('omega)-dimethyl-L-arginine + pyruvate => 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56002", "l": "beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534096", "l": "METAP1/2 demethylates GNAT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47070", "l": "4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O => 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617862", "l": "Retinoic acid activates HOXA4 chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40325", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9825704", "l": "AKT3 phosphorylates TBX3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53383", "l": "5,6-dihydrouridine(16) in tRNA + NAD(+) <=> H(+) + NADH + uridine(16) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17111", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+) => FMNH2 + N-methylnicotinate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614460", "l": "Dimerization of procollagen type VI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.22", "l": "\"endothiapepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29041", "l": "ADP + H(+) + L-aspartate(in) + phosphate => ATP + H2O + L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686578", "l": "Activated ATM phosphorylates ABL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805620", "l": "KAT6A and PML bind TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39006", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30480", "l": "L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786118", "l": "IL13 binds IL13RA:TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73369", "l": "D-xylose(in) + 2 Na(+)(in) => D-xylose(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56393", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54797", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) => an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827992", "l": "Expression of TET2 in primordial germ cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45370", "l": "(4R)-hydroxysphinganine + (9Z)-octadecenoate => H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48004", "l": "1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68429", "l": "lutein + O2 => (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17085", "l": "4-pyridoxate + A = 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2", "d": [], "t": []}, {"i": "EC:1.1.99.42", "l": "\"4-pyridoxate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66933", "l": "(E)-4-coumaroyl-CoA + 5-hydroxyanthranilate => avenanthramide A + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74507", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B = (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56379", "l": "3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052768", "l": "mannosyl-oligosaccharide 1,3-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of the alpha-(1->3) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36495", "l": "alpha-D-glucose + ATP = ADP + alpha-D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55656", "l": "2 A + a carotenoid beta-end derivative = a carotenoid chi-end derivative + 2 AH2", "d": [], "t": []}, {"i": "EC:1.3.99.40", "l": "\"carotenoid chi-ring synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11751", "l": "fluoroacetaldehyde + L-threonine <=> 4-fluoro-L-threonine + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24830", "l": "ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13174", "l": "H2O + NAD(+) + phosphonate => H(+) + NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60610", "l": "1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine => 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53302", "l": "H(+) + N-carbamoyl-D-methionine => D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032145", "l": "succinate-semialdehyde dehydrogenase binding", "d": ["Binding to succinate-semialdehyde dehydrogenase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56789", "l": "apo-[corrinoid adenosyltransferase] + cob(II)alamin => cob(II)alamin-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205262", "l": "Direct recruitment of PI3K to p-KIT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63015", "l": "(2E,6E)-farnesyl diphosphate + orsellinate <=> diphosphate + ilicicolinate B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3928619", "l": "PAK1 binds RAC1:GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8963851", "l": "VD3 dissociates from GC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69150", "l": "H2O2 + NH4(+) + spermine monoaldehyde => H2O + O2 + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51391", "l": "acetyl-CoA + dopamine <=> CoA + H(+) + N-acetyl-dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71754", "l": "2-oxoglutarate(out) + glutarate(in) <=> 2-oxoglutarate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.3", "l": "\"aldehyde dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015493", "l": "lysine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37825", "l": "2,4-dichlorophenol + CO2 + pyruvate + succinate => (R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928648", "l": "SFKs phosphorylate NGEF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050451", "l": "CoA-disulfide reductase (NADPH) activity", "d": ["Catalysis of the reaction: 2 CoA + NADP+ = CoA-disulfide + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16691", "l": "D-glucose + phosphate => D-glucose 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72648", "l": "1,6-dihydroxyphenazine + NADPH + O2 => 1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73806", "l": "dimethylallyl diphosphate + neoechinulin B <=> diphosphate + isoechinulin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35981", "l": "diphosphate + fumitremorgin A => dimethylallyl diphosphate + verruculogen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22508", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71163", "l": "HPD dioxygenates HPP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44963", "l": "(2E)-decenoyl-CoA + H(+) + NADPH <=> decanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158860", "l": "SULT1A1 dimer sulfonates NHABP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58869", "l": "24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60739", "l": "(2E,6E)-farnesal + H2O + NADP(+) <=> (2E,6E)-farnesoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839381", "l": "FGF2:TGFBR3 binding to GIPC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38482", "l": "N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine <=> H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209828", "l": "Tryptophan is hydroxylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65513", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + O2 => 5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69711", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphinganine + H2O = beta-D-glucose + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24237", "l": "2 Fe(III)-[cytochrome c] + H2O + trimethylamine => 2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66724", "l": "(S)-lactate + L-phenylalanine = H2O + N-[(S)-lactoyl]-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607746", "l": "PKC-delta is activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61559", "l": "gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174963", "l": "NAT1 acetylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46783", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23532", "l": "ATP + cholate + CoA = AMP + choloyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78501", "l": "3-(N-acetyl-N-hydroxy)aminopropylphosphonate + CMP + H(+) => CMP-5'-(N-acetyl-N-hydroxy-3-aminopropyl)phosphonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17468", "l": "H2O + quercitrin <=> L-rhamnopyranose + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37041", "l": "5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O => 5 AH2 + 2 H(+) + heme b + 4 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183122", "l": "Factor D cleaves C3b-bound Factor B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445064", "l": "Activation of Rac1 by VAV2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39800", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043961", "l": "succinyl-CoA:(R)-citramalate CoA-transferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37661", "l": "CoA + O-methyl anthranilate => anthraniloyl-CoA + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9824999", "l": "GSK3B phosphorylates p-S73 MITF-M at residue S69 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858500", "l": "CLEC10A binds Tn-MUC1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19483", "l": "3-oxoadipyl-CoA + CoA => acetyl-CoA + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.80", "l": "\"long-chain acyl-[acyl-carrier-protein] reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683774", "l": "p-T68-CHEK2 dimerizes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43865", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16594", "l": "3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine => 3,3',4',5,7-pentahydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77996", "l": "9-hydroxy-octadecanoate + a 1,2-diacyl-sn-glycerol => 9-(acyloxy)-octadecanoate + a 2-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75207", "l": "Ag(+)(out) = Ag(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49149", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21890", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + H(+) + NADPH => (1S,2S)-OPC-8 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31809", "l": "alpha-guaiene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1169406", "l": "ISGylation of host proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31176", "l": "(2E)-2-methylpropenoyl-CoA + H2O => (S)-3-hydroxyisobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952232", "l": "BCL2L11 (BIM) gene transcription is stimulated by RUNX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63733", "l": "UDP-alpha-D-glucuronate + zolasartan => UDP + zolarsartan O-beta-D-glucuronoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30702", "l": "2-oxoglutarate + beta-alanine <=> 3-oxopropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52897", "l": "2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin => 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39477", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O => (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12088", "l": "an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.80", "l": "\"ceramide glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216045", "l": "Collagen type I binds integrin alpha11beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905056", "l": "P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["A calcium-transporting P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975633", "l": "atROL binds to RBP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56623", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O <=> 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15935", "l": "(S)-lactaldehyde + H(+) + NADH => (S)-propane-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78920", "l": "a medium-chain (3S)-3-hydroxyacyl-CoA + NAD(+) => a medium-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60627", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O <=> 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061676", "l": "importin-alpha family protein binding", "d": ["Binding to a member of the importin-alpha family."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30388", "l": "GDP-alpha-D-glucose + phosphate => alpha-D-glucose 1-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73004", "l": "anthranilate + 2 ATP + L-tryptophan => (R)-benzodiazepinedione + 2 AMP + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10854", "l": "diphosphate + sophoraflavanone G => dimethylallyl diphosphate + leachianone G", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56327", "l": "(2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein] <=> 2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004937", "l": "alpha1-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32659", "l": "(6E)-8-hydroxygeraniol + 2 NADP(+) = (6E)-8-oxogeranial + 2 H(+) + 2 NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.324", "l": "\"8-hydroxygeraniol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38877", "l": "pseudouridine(2604) in 23S rRNA => uridine(2604) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74353", "l": "2 (S)-lactate(out) + prostaglandin E3(in) => 2 (S)-lactate(in) + prostaglandin E3(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9824894", "l": "TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730841", "l": "Phosphorylation and activation of VAV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701147", "l": "TRPV1 binds TRPV1 blockers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24034", "l": "6-O-alpha-D-glucopyranosyl-D-fructose => sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807008", "l": "PTPRJ dephosphorylates MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205231", "l": "Dimerization of KIT upon SCF binding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54977", "l": "(3S)-hydroxytetradecanoyl-CoA + H2O => (3S)-hydroxytetradecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707690", "l": "BACH1 binds MAFK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353056", "l": "phosphoenolpyruvate + ADP => pyruvate + ATP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63523", "l": "2-isopropylphenol + H(+) + NADH + O2 <=> 3-isopropylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374173", "l": "AGT(34-41) binds to AGTR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9858321", "l": "DHTKD1 dimer decarboxylates 2-OA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53812", "l": "cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0038199", "l": "ethylene receptor activity", "d": ["Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014456", "l": "GDIs block activation of RHOG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56696", "l": "D-ribulose 5-phosphate + L-tryptophan = (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": [], "t": []}, {"i": "EC:4.1.99.25", "l": "\"L-tryptophan isonitrile synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18603", "l": "3,4-dihydroxybenzoate + CO2 => 3,4-dihydroxyphthalate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939204", "l": "ESTG binds ESR1:chaperone complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55156", "l": "a quinone + glutathione + H(+) + hydrogen sulfide = a quinol + S-sulfanylglutathione", "d": [], "t": []}, {"i": "EC:1.8.5.8", "l": "\"eukaryotic sulfide quinone oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0032813", "l": "tumor necrosis factor receptor superfamily binding", "d": ["Binding to a member of the tumor necrosis factor receptor superfamily."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11399", "l": "5-methyldeoxycytidine 5'-phosphate + ATP <=> 5-methyldeoxycytidine diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73005", "l": "(R)-benzodiazepinedione + 2 AMP + 2 diphosphate + H(+) => anthranilate + 2 ATP + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58799", "l": "a flavonol 7-O-beta-D-glucoside + malonyl-CoA <=> a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050577", "l": "GDP-L-fucose synthase activity", "d": ["Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909552", "l": "Phosphorylation of STAT1 at Ser727 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604722", "l": "Activation of proMMP9 by proteases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937419", "l": "CBR3 reduces DOX to DOXOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28067", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) => alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65905", "l": "3-hydroxy-L-kynurenine + glyoxylate => 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193665", "l": "MYD88 dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2468040", "l": "Cohesin binds PDS5 and WAPAL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71848", "l": "glycoursodeoxycholate(out) => glycoursodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41817", "l": "a ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => a ganglioside GD2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71205", "l": "L-homoarginine(out) => L-homoarginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636247", "l": "PPE2:KPNA1:KPNB1 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.292", "l": "\"1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68100", "l": "NAD(+) + xylitol = H(+) + L-xylulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36444", "l": "dihydrochanoclavine-I aldehyde => 6,8-dimethyl-6,7-didehydroergoline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015138", "l": "fumarate transmembrane transporter activity", "d": ["Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604732", "l": "Autocatalytic activation of proMMP13 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71429", "l": "3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out) => 3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12398", "l": "dTDP-D-galacturonate + 3 H(+) + 2 NADPH => dTDP-D-galactose + H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43460", "l": "dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9823910", "l": "Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75644", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168813", "l": "SOCS binding to JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004318", "l": "enoyl-[acyl-carrier-protein] reductase (NADH) activity", "d": ["Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NAD+ = a (2E)-enoyl-[ACP] + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047021", "l": "15-hydroxyprostaglandin dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78611", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 15,20-dihydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15789", "l": "L-xylose + NADP(+) = H(+) + L-xylono-1,4-lactone + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.113", "l": "\"L-xylose 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109702", "l": "PDPK1 phosphorylates AKT2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75429", "l": "32-hydroxyeburicol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => eburicol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004778", "l": "succinyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: H2O + succinyl-CoA = CoA + H+ + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389083", "l": "Autophosphorylation of PDGF alpha receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77534", "l": "hydrogen cyanide + nonanal <=> (2S)-2-hydroxydecanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21858", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA => cyclohexa-1,5-diene-1-carbonyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76887", "l": "5-hydroxypentan-2-amine + H2O + NAD(+) = 5-hydroxypentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112037", "l": "Inactivation of PLC beta (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.84", "l": "\"glucan 1,3-alpha-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683624", "l": "mRNA2 is translated to Spike (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102298", "l": "selenocystathione synthase activity", "d": ["Catalysis of the reaction: L-selenocysteine + O-phosphonato-L-homoserine = hydrogenphosphate + L-selenocystathionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12538", "l": "CO2 + H2O + L-phenylalanine => H(+) + L-arogenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050501", "l": "hyaluronan synthase activity", "d": ["Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672172", "l": "PI3-kinase binds to mutant PDGFR receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14908", "l": "5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate <=> 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34972", "l": "Fe(3+)(in) => Fe(3+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.75", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54974", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP] => 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53119", "l": "an 11beta-hydroxysteroid + NAD(+) <=> an 11-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38299", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19327", "l": "H2O + NAD(+) + quinoline-3,4-diol => H(+) + NADH + O2 + quinolin-4-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21306", "l": "ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32073", "l": "(13E)-labda-7,13-dien-15-yl diphosphate => geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55634", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+) => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667456", "l": "AVPR1A,B bind desmopressin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854628", "l": "MYLIP dimer ubiquitinates VLDLR on Lys-839 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51762", "l": "a 2-acyl-4,6,6-triprenylphloroglucinol + diphosphate => a 2-acyl-4,6-diprenylphloroglucinol + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033230", "l": "ABC-type cysteine transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(out/in) = ADP + phosphate + cysteine(in/out)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008876", "l": "quinoprotein glucose dehydrogenase activity", "d": ["Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158357", "l": "factor XIIa binds SERPING1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707516", "l": "FeHM dissociates from MetHb (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106436", "l": "glutathione-dependent sulfide quinone oxidoreductase activity", "d": ["Catalysis of the reaction: a quinone + glutathione + H+ + hydrogen sulfide = a quinol + S-sulfanylglutathione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36558", "l": "eicosanoyl-CoA + sphinganine <=> CoA + H(+) + N-eicosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805285", "l": "PLK3 phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8853496", "l": "SCF:FBXL7 binds AURKA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53177", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10050", "l": "acetate + H(+) + L-methionine => methanethiol + O-acetyl-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29990", "l": "adenosine(in) + H(+)(in) <=> adenosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45888", "l": "12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18906", "l": "H2O + phosphonoacetaldehyde => acetaldehyde + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14209", "l": "alpha-D-galactose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-galactose", "d": [], "t": []}, {"i": "EC:2.7.7.10", "l": "\"UTP--hexose-1-phosphate uridylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388596", "l": "Melanocortin receptors bind melanocortins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23511", "l": "(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O <=> (7R)-7-aminocephalosporanate + glutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564169", "l": "Collagen type VIII degradation by MMP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51451", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63725", "l": "candesartan + UDP-alpha-D-glucuronate => candesartan O-beta-D-glucuronoside + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33363", "l": "D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannitol 1-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.197", "l": "\"protein-N(pi)-phosphohistidine--D-mannitol phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76870", "l": "(R)-1-phenylethylamine + H2O + NAD(+) <=> acetophenone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851352", "l": "CCR8 binds CCL1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183067", "l": "Localization of CBL:GRB2 to the membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33362", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109807", "l": "GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12441", "l": "H2O + L-saccharopine + NAD(+) => 2-oxoglutarate + H(+) + L-lysine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24837", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805022", "l": "USP2 binds the heterodimer of MDM2 and MDM4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58885", "l": "AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 => A + chloramphenicol + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858287", "l": "MITF-M dimer binds the TRPM1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696357", "l": "LAIR2 binds collagen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372542", "l": "Loading of dopamine into synaptic veiscles (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015087", "l": "cobalt ion transmembrane transporter activity", "d": ["Enables the transfer of cobalt (Co2+) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32362", "l": "1D-myo-inositol 1,4,5-trisphosphate + 2 ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203901", "l": "Pol II mediated transcription of microRNA genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839378", "l": "TGFBR3 binding to ARRB1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31649", "l": "5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754616", "l": "SARS-CoV-2 E pentamer transports Ca2+  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005340", "l": "Expression of SOCS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63836", "l": "hexadecanoate + O2 = (2R)-2-hydroperoxyhexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62639", "l": "a hydroperoxide + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein] <=> an alcohol + H2O + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354097", "l": "Activation of Talin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444691", "l": "Prokineticin receptors bind prokineticin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428262", "l": "ACER3 hydrolyzes phytoceramide (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62832", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36941", "l": "(9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47639", "l": "H2O + L-arginine + NADP(+) <=> 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34746", "l": "15-methylhexadecasphinganine 1-phosphate <=> 13-methyltetradecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097244", "l": "flavonol binding", "d": ["Binding to a flavonol, a flavonoid that contains a 3-hydroxy-2-phenylchromen-4-one backbone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31644", "l": "mycinamicin VI + S-adenosyl-L-methionine => H(+) + mycinamicin III + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008684", "l": "TBK1 phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936985", "l": "Activated TLR4:TICAM1 recruits TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9842839", "l": "ATF7IP:SETDB1 binds SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9824892", "l": "MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009072", "l": "STAT3 phosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944263", "l": "Association of procollagen type II (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004598", "l": "peptidylamidoglycolate lyase activity", "d": ["Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69753", "l": "(E)-cinnamoyl-CoA + CO2 + H2O2 => benzylmalonyl-CoA + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14655", "l": "a nucleoside 5'-phosphate + H(+) => a nucleoside 3',5'-cyclic phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008020", "l": "G protein-coupled photoreceptor activity", "d": ["Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29967", "l": "2'-deoxyuridine(in) + H(+)(in) = 2'-deoxyuridine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830418", "l": "GATA3 binds the LHX1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29120", "l": "a ubiquinol + nitrate => a ubiquinone + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34741", "l": "H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine => H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607023", "l": "factor IXa associates with cell membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28148", "l": "3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37090", "l": "[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine <=> 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798372", "l": "ATM phosphorylates DYRK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674529", "l": "AAMP binds to TBXA2R (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15627", "l": "Co-precorrin-6A + H(+) + NADH => Co-precorrin-6B + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466369", "l": "NRF1:PPARGC1B binds the ATP5B promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0071553", "l": "G protein-coupled pyrimidinergic nucleotide receptor activity", "d": ["Combining with a pyrimidine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34147", "l": "2-deoxy-L-scyllo-inosose + L-glutamine = 2-deoxy-scyllo-inosamine + 2-oxoglutaramate", "d": [], "t": []}, {"i": "EC:2.6.1.100", "l": "\"L-glutamine:2-deoxy-scyllo-inosose aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37266", "l": "ATP + H2O + L-alanyl-L-aspartate(out) <=> ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64536", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": [], "t": []}, {"i": "EC:2.7.1.227", "l": "\"inositol phosphorylceramide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.19", "l": "\"3-phenylpropanoate dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24332", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate = H2O + monacolin L carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296127", "l": "Activation of voltage gated Potassium channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332359", "l": "Active calmodulin binds CAMK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944265", "l": "Association of procollagen type IV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59148", "l": "ATP + CoA + marinolate C = AMP + diphosphate + marinoloyl-CoA C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617838", "l": "CDKN1A gene transcription is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811427", "l": "COPI vesicle uncoating at the ER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68657", "l": "7-oxocholesterol + H(+) + NADPH => 7beta-hydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045544", "l": "gibberellin 20-oxidase activity", "d": ["Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65584", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] = 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22338", "l": "L-methionine + N,N-dimethylglycine => glycine betaine + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12823", "l": "acetaldehyde + D-glyceraldehyde 3-phosphate => 2-deoxy-D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25335", "l": "H2O + L-cysteinyl-tRNA(Cys) => H(+) + L-cysteine + tRNA(Cys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23460", "l": "benzyl cetraxate + H2O = benzyl alcohol + cetraxate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.70", "l": "\"cetraxate benzylesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74149", "l": "benzoyl-CoA + succinyl-CoA => (S)-2-benzoylsuccinyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73896", "l": "ATP + L-glutamate + spermine => ADP + gamma-L-glutamylspermine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018860", "l": "anthranilate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21923", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53999", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202510", "l": "Activation of TAK1-TAB2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42426", "l": "(2R,3S)-3-methylmalate => 2-methylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10029", "l": "D-glutamate + H2O + O2 => 2-oxoglutarate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23759", "l": "D-arabinono-1,4-lactone + O2 <=> dehydro-D-arabinono-1,4-lactone + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67696", "l": "H2O + hexadecanedioyl-CoA = CoA + H(+) + hexadecanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55799", "l": "H(+) + NADH + O2 + phenol <=> H2O + hydroquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74925", "l": "a (2E)-enoyl-[ACP] + glycine + H2O => a (3R)-3-[(carboxymethyl)amino]fatty acid + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19458", "l": "2-nitrophenol + 2 H(+) + 2 NADPH + O2 => catechol + H2O + 2 NADP(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48425", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O => (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74828", "l": "UDP-alpha-D-galacturonate(in) + UMP(out) => UDP-alpha-D-galacturonate(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70174", "l": "H(+)(in) + pemetrexed(in) <=> H(+)(out) + pemetrexed(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753916", "l": "NAPQI binds proteins in hepatocytes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66336", "l": "L-glutamate(out) = L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3321883", "l": "MSL acetylates histone H4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12413", "l": "(2R)-3-phosphoglycerate + H2O => (R)-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627104", "l": "XIAP binds CASP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78499", "l": "CMP-5'-(N-acetyl-N-hydroxy-3-aminopropyl)phosphonate + H2O = 3-(N-acetyl-N-hydroxy)aminopropylphosphonate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19921", "l": "D-ribitol 5-phosphate + NADP(+) = D-ribulose 5-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63498", "l": "4-nitrobenzyl alcohol + NADP(+) => 4-nitrobenzaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433550", "l": "palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24049", "l": "phosphate + sucrose => alpha-D-glucose 1-phosphate + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638845", "l": "CERK phosphorylates CERA to form C1P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34145", "l": "Delta(9)-tetrahydrocannabinolate + H2O2 => cannabinerolate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2984226", "l": "PLK1 phosphorylates NEK9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53298", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH => (2E)-decenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9634861", "l": "NPAS4 binds ARNT2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40401", "l": "H2O2 + NADP(+) => 1,2-dihydro-beta-NADP + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13008", "l": "(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine <=> H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52564", "l": "2-dehydro-L-erythronate = 3-dehydro-L-erythronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29227", "l": "H(+)(in) + indole(in) = H(+)(out) + indole(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43988", "l": "(2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2 = (2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39030", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25558", "l": "diphosphate + stemod-13(17)-ene => 9alpha-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158313", "l": "factor XII -> factor XIIa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20268", "l": "2-oxoglutarate + L-proline + O2 <=> cis-3-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40085", "l": "26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31512", "l": "chenodeoxycholoyl-CoA + H2O => chenodeoxycholate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38352", "l": "(R)-3-phenyllactate + NAD(+) => 3-phenylpyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656893", "l": "OPN1MW binds 11cRAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419465", "l": "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071551", "l": "RIP homotypic interaction motif binding", "d": ["Binding to a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804266", "l": "CHEK2 phosphorylates TTC5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77910", "l": "H2O + 2 O2 + sym-homospermidine <=> 1-formylpyrrolizidine + 2 H2O2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429992", "l": "PARN deadenylates mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549129", "l": "OCT1 transports organic cations into hepatic cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635854", "l": "GLI2,3 are degraded by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948027", "l": "RNASEs bind bacterial phospholipids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16165", "l": "L-tryptophan + O2 = CO2 + H2O + indole-3-acetamide", "d": [], "t": []}, {"i": "EC:1.13.12.3", "l": "\"tryptophan 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78941", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72752", "l": "H2O + ochratoxin A => L-phenylalanine + ochratoxin alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44029", "l": "L-altrarate => 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.2", "l": "\"aminopyrimidine aminohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833635", "l": "p-PKR dimer localizes to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12407", "l": "D-glucose + UDP-alpha-D-galactose <=> H(+) + lactose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22337", "l": "glycine betaine + L-homocysteine => L-methionine + N,N-dimethylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78233", "l": "H(+) + O-5''-beta-D-galactosylqueuosine(34) in tRNA(Tyr) + UDP => queuosine(34) in tRNA(Tyr) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.79", "l": "\"hormone-sensitive lipase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662599", "l": "MT1M binds cadmium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31771", "l": "an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55004", "l": "1-hydroxylimonen-2-one + NADPH + O2 = 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202510", "l": "Activation of TAK1-TAB2 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60405", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O => Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-825631", "l": "Glucagon:GCGR mediates GTP-GDP exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35867", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40327", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70879", "l": "L-glutamine(in) + L-threonine(out) + Na(+)(out) = L-glutamine(out) + L-threonine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.120", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27366", "l": "bromide + S-adenosyl-L-methionine => bromomethane + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16386", "l": "4-hydroxybenzoate + 2 H(+) + NADPH + O2 => CO2 + H2O + hydroquinone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74327", "l": "O-propanoyl-(R)-carnitine(in) = O-propanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72086", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O <=> ADP-alpha-D-ribose 1''-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694732", "l": "3CLp cleaves pp1ab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9736953", "l": "FURIN translocates to the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250600", "l": "botD:SV2:GD2 internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.45", "l": "\"N-acetylneuraminate 7-O(or 9-O)-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380316", "l": "Association of NuMA with microtubules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19335", "l": "CO2 + formyl-CoA => H(+) + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37915", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047252", "l": "beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity", "d": ["Catalysis of the reaction: (1->6)-alpha-D-mannosyloligosaccharide + beta-D-mannosylphosphodecaprenol = (1->6)-alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419389", "l": "LPA-binding receptors bind LPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43012", "l": "L-homocysteine = 2-aminobut-2-enoate + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810392", "l": "TMEM55B translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73702", "l": "ADP(in) + dATP(out) <=> ADP(out) + dATP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717395", "l": "TRPM5 transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046538", "l": "2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity", "d": ["Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; this reaction mechanism uses 2,3-bisphosphoglycerate as a phosphate donor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213200", "l": "Release of endostatin-like peptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352107", "l": "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683735", "l": "CHEK2 is recruited to DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804425", "l": "TP53 binds POU4F2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76310", "l": "L-aspartate(in) + L-glutamate(out) <=> L-aspartate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976801", "l": "Complement factor I complex formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613648", "l": "SOX10 dimer binds the POU3F1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008843", "l": "endochitinase activity", "d": ["Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65850", "l": "a steroid 1,3-dione + AH2 => A + a 3-oxo-Delta(1)-steroid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61970", "l": "a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62541", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain => dihydroouabain + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754518", "l": "SARS-CoV-2 3a tetramer binds to CAV1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549304", "l": "OCT3 mediates renal clearance of organic cations (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "43.99996216224978", "identifiers": [{"i": "GO:0004888", "l": "transmembrane signaling receptor activity", "d": ["Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction."], "t": []}, {"i": "REACT:R-HSA-193672", "l": "Sphingomyelinase is activated by the NGF:p75NTR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72888", "l": "O2 + polyporic acid + reduced [NADPH--hemoprotein reductase] => ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641236", "l": "USP8 deubiquitinates FZD to potentiate WNT signaling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47080", "l": "17beta-hydroxyestr-4-en-3-one + H(+) + NADPH = 17beta-hydroxy-5beta-estran-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425861", "l": "Activation of Protein Kinase C novel isoforms (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19040", "l": "an epoxide + H2O <=> an ethanediol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9860290", "l": "TASL recruits IRF5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.79", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20897", "l": "ATP + hydrogencarbonate + urea => ADP + H(+) + phosphate + urea-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30078", "l": "CMP + H2O <=> cytosine + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52055", "l": "9-hexadecanoyloxy-octadecanoate + H2O <=> 9-hydroxy-octadecanoate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5221061", "l": "TDG excises 5-carboxylcytosine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6813749", "l": "ALDH1A1 oxidises GA to DGA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193753", "l": "3,7,24THCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60688", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) = (11R)-dihydroartemisinate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76420", "l": "2-hydroxymethyl-3-pentylphenol + O2 + reduced [NADPH--hemoprotein reductase] => (8S)-annullatin E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10877", "l": "4-hydroxybenzoate + H(+) => CO2 + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72405", "l": "2-oxoglutarate(in) + urate(out) => 2-oxoglutarate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10741", "l": "a secondary alcohol + NAD(+) => a ketone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10437", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9676255", "l": "Formation of the MLL2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875817", "l": "MET phosphorylates STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39933", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27338", "l": "2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] => 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71303", "l": "RPE dimers isomerise RU5P to XY5P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68854", "l": "(1S,6S,7R)-sesquipiperitol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71847", "l": "glycoursodeoxycholate(out) = glycoursodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70733", "l": "4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in) => 4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39024", "l": "an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57007", "l": "acetyl-CoA + streptothricin D <=> CoA + H(+) + N(beta)-acetylstreptothricin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855054", "l": "Ficolin-2 binds to molecular patterns on the target cell surface  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28286", "l": "a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939201", "l": "ESR dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5681987", "l": "LC3 is cleaved by ATG4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47686", "l": "[(1->2)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->2)-beta-D-glucosyl](n) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0017089", "l": "glycolipid transfer activity", "d": ["Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753634", "l": "GGT dimers hydrolyse APAP-SG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.17", "l": "\"methylthioalkylmalate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.159", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944215", "l": "Association of procollagen type XX (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093329", "l": "EFNBs bind SDCBP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48558", "l": "4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate => 4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25611", "l": "beta-D-allopyranose => beta-D-allofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65299", "l": "(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036122", "l": "BMP binding", "d": ["Binding to a member of the bone morphogenetic protein (BMP) family."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58785", "l": "2-oxoglutarate + a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + O2 => a 5'-end triphospho-guanosine-ribonucleotide-snRNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67453", "l": "a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O => 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840334", "l": "PSAP gets cleaved (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43311", "l": "1-hexadecanoyl-sn-glycerol + ATP <=> 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72417", "l": "Li(+)(out) + Na(+)(in) => Li(+)(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-538904", "l": "Phosphorylated PER binds to CLK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202604", "l": "Formation of a heteromeric BMP receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351876", "l": "Caspase-mediated cleavage of occludin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014454", "l": "RHOG translocates to the ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26221", "l": "abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.145", "l": "\"abieta-7,13-dien-18-ol hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193668", "l": "p75NTR and RHOA-GDI interact (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44921", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH => (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29598", "l": "CoA + NADP(+) + sulfoacetaldehyde <=> H(+) + NADPH + sulfoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71798", "l": "(R)-3-hydroxybutanoate(out) + H(+)(out) <=> (R)-3-hydroxybutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65128", "l": "1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19155", "l": "7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP => apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28950", "l": "H(+)(out) + L-arabinose(in) <=> H(+)(in) + L-arabinose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68133", "l": "phytol + tetradecanoyl-CoA => CoA + tetradecanoate phytyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20469", "l": "H2O + IMP = D-ribose 5-phosphate + hypoxanthine", "d": [], "t": []}, {"i": "EC:3.2.2.12", "l": "\"inosinate nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3899291", "l": "SUMOylation of EP300 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66950", "l": "alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA => acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16437", "l": "glutathione + RX = a halide anion + an S-substituted glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24676", "l": "ADP + CMP + H(+) => ATP + cytidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70859", "l": "L-asparagine(in) + L-glutamine(out) + Na(+)(out) = L-asparagine(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66055", "l": "indole-3-pyruvate + L-kynurenine <=> H2O + kynurenate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61937", "l": "ATP + cycloheximide(in) + H2O => ADP + cycloheximide(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64393", "l": "a dipeptide(out) + H(+)(out) => a dipeptide(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008388", "l": "testosterone 15-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32176", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose => alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013711", "l": "HES1 gene expression is stimulated by NOTCH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0090079", "l": "translation regulator activity, nucleic acid binding", "d": ["Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59397", "l": "L-leucine => D-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5340226", "l": "CYGB dioxygenates NO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9858647", "l": "HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420202", "l": "Secretin receptor binds secretin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71561", "l": "5-aminomethyl-dUMP in DNA + AH2 + glyoxylate => 5-N(alpha)-glycyl-dTMP in DNA + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787820", "l": "IL34 dimer binds CSF1R (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213241", "l": "Formation of nonameric complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10732", "l": "ATP + firefly D-luciferin + O2 = AMP + CO2 + diphosphate + firefly oxyluciferin + hnu", "d": [], "t": []}, {"i": "EC:1.13.12.7", "l": "\"firefly luciferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15547", "l": "acetate + pyruvate => (3S)-citramalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16911", "l": "2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+) => 2 Fe(III)-[cytochrome c] + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69612", "l": "H2O + kojibiose => beta-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29259", "l": "(2R,3R)-tartrate(out) + succinate(in) = (2R,3R)-tartrate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190265", "l": "FGFR4 binds to FGF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442586", "l": "Activation of WASP and N-WASP by CDC42 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019531", "l": "oxalate transmembrane transporter activity", "d": ["Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54602", "l": "2-hydroxyoctanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42285", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40109", "l": "1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23336", "l": "2 H(+) + H2O2 + 2 iodide = diiodine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165680", "l": "Formation of active mTORC1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13280", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate <=> [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76945", "l": "H(+) + hexan-3-one + NADPH + NH4(+) => 3-aminohexane + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2468040", "l": "Cohesin binds PDS5 and WAPAL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160931", "l": "Disassembly of tight junctions (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61284", "l": "H2O + L-cystine + O2 = (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55567", "l": "4-hydroxytryptamine + ATP <=> 4-hydoxytryptamine 4-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20820", "l": "choline sulfate + H2O = choline + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.6", "l": "\"choline-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34423", "l": "(-)-secoisolariciresinol + NADP(+) = (+)-lariciresinol + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.23.1.2", "l": "\"(+)-lariciresinol reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51830", "l": "AMP(in) + diphosphate(in) + docosanoyl-CoA(in) + H(+)(in) => ATP(in) + CoA(in) + docosanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24259", "l": "ATP + kanamycin A <=> ADP + H(+) + kanamycin 3'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57248", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP = dGTP + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33718", "l": "4-hydroxyeicosasphinganine 1-phosphate <=> 2-hydroxyoctadecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379887", "l": "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625424", "l": "The retrograde IFT train dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928640", "l": "PAKs phosphorylate MLC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10837", "l": "NADPH + O2 + questin => demethylsulochrin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18755", "l": "[protein]-disulfide + H(+) + NADPH => [protein]-dithiol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112118", "l": "Oxidative demethylation of 1-meA damaged DNA by ALKBH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16084", "l": "(2R)-S-methyl-3-phospho-1-thioglycerate + H2O <=> (2R)-S-methyl-1-thioglycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047861", "l": "diiodotyrosine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170057", "l": "RNA ligase (GTP) activity", "d": ["Catalysis of the joining of an RNA with 3'-phosphate or 2',3'-cyclic-phosphate ends to an RNA with 5'-hydroxy ends according to either (i) a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP; or (ii) a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328048", "l": "Emilin is found in elastic fibres (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913446", "l": "Interleukin-5 is a homodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20840", "l": "H(+) + L-histidine = CO2 + histamine", "d": [], "t": []}, {"i": "EC:4.1.1.22", "l": "\"histidine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864577", "l": "TFAP2C translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051371", "l": "muscle alpha-actinin binding", "d": ["Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021050", "l": "HSBP1 oligomer binds ESRs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604368", "l": "Autocatalytic activation of bound proMMP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16057", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.145", "l": "\"alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034809", "l": "benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene-cis-4,5-dihydrodiol = 4,5-dihydroxybenzo(a)pyrene + H2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.4", "l": "\"rubredoxin--NAD(P)(+) reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350444", "l": "ROK phosphorylates SQH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70724", "l": "sitosterol(out) => sitosterol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57503", "l": "3-hydroxybutane-1,2,3-tricarboxylate <=> 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72518", "l": "(R)-carnitine(out) + glutarate(in) <=> (R)-carnitine(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450494", "l": "HuR binds mRNAs in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40286", "l": "(R)-carnitine + hexadecanedioyl-CoA <=> CoA + O-hexadecanedioyl-L-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.54", "l": "\"ketosteroid monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3791319", "l": "NID1 degradation by MMP19 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34881", "l": "4-methoxy-4-oxo-3-phenylbutanoate + NH4(+) => 2 H2O + methyl 3-cyano-2-phenylpropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42866", "l": "H(+) + norspermine + S-methyl-5'-thioadenosine => norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47510", "l": "isolithocholate + NAD(+) => 3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72779", "l": "chloride + FADH2 + O2 + ochratoxin B = FAD + 2 H2O + ochratoxin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57099", "l": "AH2 + S-methyl-1-thio-D-xylulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + A + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38924", "l": "a ubiquinone + H(+) + Na(+)(in) + NADH => a ubiquinol + Na(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156910", "l": "Formation of eEF1B complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25726", "l": "L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618093", "l": "ATP hydrolysis by HSP90 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404200", "l": "IGF1,2 binds IGF1R (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35813", "l": "(-)-medicarpin + H2O => (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56937", "l": "17beta-hydroxy-androst-5-en-3-one => testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64532", "l": "an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987214", "l": "p-STAT3 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669158", "l": "NF2 binds PAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848250", "l": "ACBD6 binds LCFA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44988", "l": "(R)-carnitine + 2-methylpropanoyl-CoA = CoA + O-isobutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23284", "l": "isopentenyl diphosphate = dimethylallyl diphosphate", "d": [], "t": []}, {"i": "EC:5.3.3.2", "l": "\"isopentenyl-diphosphate Delta-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62013", "l": "cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54764", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine = [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0048763", "l": "calcium-induced calcium release activity", "d": ["Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211874", "l": "CYP2S1 4-hydroxylates atRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010307", "l": "acetylglutamate kinase regulator activity", "d": ["Binds to and modulates the activity of acetylglutamate kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72470", "l": "2 acetyl-CoA + 5 H(+) + 6 malonyl-CoA <=> 6 CO2 + 8 CoA + H2O + o-orsellinate depside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10614", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69011", "l": "2 H(+) + L-aspartate + 3 NADPH + 3 O2 <=> 2-nitrobutanedioate + 4 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008499", "l": "UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628737", "l": "NEIL1 G83D does not cleave DHU (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46644", "l": "cortisol + H(+) + NADPH = 5beta-dihydrocortisol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57576", "l": "7-deoxyloganate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + loganate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25796", "l": "2-oxoglutarate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373140", "l": "isocitrate <=> citrate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38406", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68255", "l": "L-tryptophan(in) + Na(+)(in) <=> L-tryptophan(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41863", "l": "(3R)-hydroxydecanoyl-[ACP] <=> (2E)-decenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428205", "l": "ACER2 hydrolyzes ceramide (Golgi) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45021", "l": "L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66452", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) = 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16330", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53788", "l": "allodeoxycholoyl-CoA + beta-muricholate = allodeoxycholate + beta-muricholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48562", "l": "D-ribose 5-phosphate + N(6)-dimethylallyladenine => H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635861", "l": "NUMB:ITCH binds GLI1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49493", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48219", "l": "H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24232", "l": "2-dehydro-3-deoxy-D-gluconate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.127", "l": "\"2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32520", "l": "(2E)-geranyl diphosphate + S-adenosyl-L-methionine => (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358619", "l": "EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42560", "l": "uridine(27/28) in mitochondrial tRNA = pseudouridine(27/28) in mitochondrial tRNA", "d": [], "t": []}, {"i": "EC:5.4.99.44", "l": "\"mitochondrial tRNA pseudouridine(27/28) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140682", "l": "FAD-dependent H3K4me/H3K4me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40812", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20159", "l": "an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+) => a polyvinyl alcohol + 2n Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.7.9", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53678", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858475", "l": "ppDVL recruits RAC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56388", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 = (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0031811", "l": "G protein-coupled nucleotide receptor binding", "d": ["Binding to a G protein-coupled (metabotropic) nucleotide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74285", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB => a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866277", "l": "AP-2 directly binds some endocytic cargo (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950740", "l": "CANX dissociates from IL12A:EBI3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608825", "l": "DVL2 is phosphorylated after WNT5A binding to FZD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76818", "l": "D-alanine + H2O + NAD(+) <=> H(+) + NADH + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008413", "l": "8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity", "d": ["Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36167", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.89", "l": "\"5'-deoxynucleotidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677050", "l": "Formation of the GCN5-ATAC complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.890252963484144", "identifiers": [{"i": "GO:0034212", "l": "peptide N-acetyltransferase activity", "d": ["Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33943", "l": "H(+) + 2 L-arginine + 3 NADH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68439", "l": "(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 <=> (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9006873", "l": "IL21 receptor STAT binding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57445", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198756", "l": "ERK1/2 phosphorylates MSK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162186", "l": "COQ3 methylates DeMQ10H2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74935", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2 2-oxoglutarate + 2 O2 = (3R)-3-isocyanylbutanoate + 3 CO2 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49903", "l": "5,10-dihydrophenazine-1,6-dicarboxylate + O2 <=> H2O2 + phenazine-1,6-dicarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018827", "l": "1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity", "d": ["Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52930", "l": "2 GMP + 2 H(+) => 3',3'-c-di-GMP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57682", "l": "a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a flavanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13891", "l": "AMP + FMN + 2 H(+) => FAD + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44030", "l": "5-dehydro-4-deoxy-D-glucarate + H2O => L-altrarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928604", "l": "SFKs phosphorylate VAV2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63748", "l": "UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-2-N-beta-D-glucuronide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794058", "l": "NOG binds BMP4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004133", "l": "glycogen debranching enzyme activity", "d": ["Catalysis of the cleavage of branch points in branched glycogen polymers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031733", "l": "CCR8 chemokine receptor binding", "d": ["Binding to a CCR8 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42452", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate = H2O + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21145", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63684", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP = (4R,5S)-dethiobiotin + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4647594", "l": "SAHF formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54154", "l": "a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10021", "l": "H2O + L-saccharopine + NADP(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39166", "l": "3-oxohexadecanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyhexadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69320", "l": "glucoerucin + H2O = (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11241", "l": "ATP + thiamine diphosphate => ADP + thiamine triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005297", "l": "proline:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378952", "l": "Thyrotropin is a heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70982", "l": "FH tetramer hydrates fumarate to L-malate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74678", "l": "AH2 + archaeol + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaeol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218814", "l": "PAK2 autophorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001078", "l": "(1->6)-beta-D-glucan binding", "d": ["Binding to (1->6)-beta-D-glucan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19824", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686625", "l": "LAIR1 binds collagen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44606", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848110", "l": "SOCS3 binds activated PTK6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42423", "l": "2-oxoglutarate + L-lysine + O2 <=> (4R)-4-hydroxy-L-lysine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.14", "l": "\"5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351936", "l": "Caspase-mediated cleavage of claspin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66224", "l": "asc-C9-CoA + O2 = asc-DeltaC9-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9861626", "l": "SIRT4 cleaves lipoyl from DLAT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56962", "l": "a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate => a ribonucleoside 5'-triphosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45286", "l": "CoA + H(+) + N-eicosanoyl-sphing-4-enine => eicosanoyl-CoA + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012209", "l": "Estrogen-responsive KPNA2 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13757", "l": "(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose = (Z)-desulfoglucotropeolin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809680", "l": "MTMR12 binds MTM1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9676264", "l": "Formation of the SET1B complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29043", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)", "d": [], "t": []}, {"i": "EC:2.1.1.148", "l": "\"thymidylate synthase (FAD)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805399", "l": "TAF1 phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43456", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448627", "l": "Interleukin-35 translocates from the ER lumen to the extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47060", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34473", "l": "acryloyl-CoA + H(+) + NADH => NAD(+) + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050530", "l": "glucosylglycerol 3-phosphatase activity", "d": ["Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H2O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645428", "l": "ALPK1 binds ADP-heptose (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.58", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187575", "l": "Ubiquitination of phospho-p27/p21 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16957", "l": "3',5'-cyclic GMP + H2O = GMP + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.35", "l": "\"3',5'-cyclic-GMP phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864361", "l": "KCTD15 binds TFAP2 homo- and heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162194", "l": "COQ7:COQ9 octamer hydroxylates DMQ10H2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59602", "l": "5-methoxyindoleacetaldehyde + H2O2 + NH4(+) => 5-methoxytryptamine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78031", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = a 1,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15044", "l": "bis-D-fructose 2',1:2,1'-dianhydride + H2O <=> inulobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022396", "l": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-43) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37974", "l": "H(+) + NADPH + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41640", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA = 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.41", "l": "\"3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-901047", "l": "Binding of ERp57 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371582", "l": "HSBP1 binds HSF1 trimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51719", "l": "ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) <=> AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804099", "l": "HMGB1 binds LTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59234", "l": "diphosphate + hydropyrenol => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51166", "l": "5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632668", "l": "SMO translocates to the cilium (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.133", "l": "\"N(alpha)-acyl-L-glutamine aminoacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174058", "l": "Degradation of multiubiquitinated Cdh1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56863", "l": "a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate <=> a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623558", "l": "Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2090079", "l": "GLB1 hydrolyses linker chain(2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62338", "l": "adenosine 3'-diphosphate,5'-phosphate + AMP + H(+) => AMP + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354097", "l": "Activation of Talin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57185", "l": "L-cysteinyl-[protein] + methylglyoxal => S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010296", "l": "prenylcysteine methylesterase activity", "d": ["Catalysis of the reaction: protein C-terminal S-farnesyl-L-cysteine methyl ester + H2O = protein C-terminal S-farnesyl-L-cysteine + methanol + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031624", "l": "ubiquitin conjugating enzyme binding", "d": ["Binding to a ubiquitin conjugating enzyme, any of the E2 proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27679", "l": "ATP + dCDP => ADP + dCTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28930", "l": "3,4,5-trihydroxybenzoate + O2 <=> (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61846", "l": "H(+) + solasodine 3-beta-D-glucoside + UDP => solasodine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.43", "l": "\"atroxase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102694", "l": "kinetin UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + kinetin = H+ + 9-(alpha-D-glucosyl)kinetin + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50641", "l": "2-(2-methylsulfanyl)ethylmalate => 3-(2-methylsulfanyl)ethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17838", "l": "2-carboxy-D-arabinitol 1-phosphate + H2O => 2-carboxy-D-arabinitol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61228", "l": "H2O + L-histidine + O2 = 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48567", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O <=> D-ribose 5-phosphate + trans-zeatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61894", "l": "a 4,5-saturated-(3E)-enoyl-CoA + NADP(+) => a (2E,4Z)-dienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805740", "l": "SETD8 methylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36222", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201685", "l": "Beta-catenin is released from the destruction complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161538", "l": "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.19", "l": "\"phosphorylase kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428534", "l": "Recruitment of Profilin by Ena/VASP proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20160", "l": "a polyvinyl alcohol + 2n Fe(III)-[cytochrome c] <=> an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25286", "l": "lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112429", "l": "Formation of FACT complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32309", "l": "H2O + leukotriene A4 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72878", "l": "anthocyanin A7 + malonyl-CoA <=> anthocyanin A9 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163213", "l": "Transfer of electrons through the succinate dehydrogenase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11597", "l": "H(+) + orotidine 5'-phosphate => CO2 + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63714", "l": "a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106408", "l": "diadenylate cyclase activity", "d": ["Catalysis of the reaction: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56584", "l": "1,2-epoxypropane + H2O = propane-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11434", "l": "7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40801", "l": "2-methylpropanoate + CoA + H(+) => 2-methylpropanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046989", "l": "galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity", "d": ["Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.99.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047253", "l": "alpha-1,6-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65874", "l": "17beta-hydroxyandrostan-1,3-dione + AH2 => 1,17beta-dihydroxyandrostan-3-one + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098770", "l": "FBXO family protein binding", "d": ["Binding to a member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32244", "l": "alpha-D-ribose 1,5-bisphosphate => D-ribulose 1,5-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56079", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658438", "l": "SPRED dimer binds NF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31023", "l": "squalene = dammara-20,24-diene", "d": [], "t": []}, {"i": "EC:5.4.99.37", "l": "\"dammaradiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871265", "l": "YAP1 binds TEAD4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78268", "l": "H2O + omega-dicarboxyl-CoA => a dicarboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647980", "l": "mature RAS proteins translocate to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785409", "l": "NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865090", "l": "UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749215", "l": "MCM8 binds CDC6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35247", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O = ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23670", "l": "AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase] => apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.28", "l": "\"glucosyl-DNA beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44412", "l": "3-demethylubiquinol-10 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18297", "l": "a phtalamide + H2O = a primary amine + phthalate", "d": [], "t": []}, {"i": "EC:3.5.1.79", "l": "\"phthalyl amidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64364", "l": "prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67162", "l": "6'-chloromelleolide F + FAD + H(+) + 2 H2O => chloride + FADH2 + melleolide F + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24459", "l": "alpha-ribazole 5'-phosphate + H2O <=> alpha-ribazole + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983158", "l": "Trimming of peptides in ER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63613", "l": "prunetin + UDP-alpha-D-glucuronate => prunetin-5-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008043", "l": "MAPK8 phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21668", "l": "ATP + H2O + sn-glycerol 3-phosphate(out) = ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)", "d": [], "t": []}, {"i": "EC:7.6.2.10", "l": "\"ABC-type glycerol 3-phosphate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37694", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA <=> 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380294", "l": "Loss of C-Nap-1 from centrosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12414", "l": "(R)-glycerate + phosphate => (2R)-3-phosphoglycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56493", "l": "hederagenin + O2 + reduced [NADPH--hemoprotein reductase] => gypsogenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16466", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c553] => 2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9861616", "l": "DLD dimer dehydrogenates dihydrolipoyl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868236", "l": "BAR domain proteins recruit dynamin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78418", "l": "carbendazim + H2O <=> H(+) + methanol + N-(1H-1,3-benzodiazol-2-yl)carbamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77053", "l": "3,5-dimethylcyclohexanone + H(+) + NADPH + NH4(+) => 3,5-dimethylcyclohexanamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67632", "l": "a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin] = a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:7.1.1.10", "l": "\"ferredoxin--quinone oxidoreductase (H(+)-translocating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17133", "l": "ATP + L-seryl-[tyrosine-3-monooxygenase] = ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]", "d": [], "t": []}, {"i": "EC:2.7.11.6", "l": "\"[tyrosine 3-monooxygenase] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58893", "l": "3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 => adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27661", "l": "2-deoxy-alpha-D-ribose 1-phosphate <=> 2-deoxy-D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67524", "l": "4,8-dimethylnonanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70773", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50474", "l": "(2-aminobenzoyl)acetyl-CoA + CO2 + CoA => anthraniloyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14709", "l": "a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27689", "l": "ATP + GDP <=> ADP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16457", "l": "(2R,3S)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69136", "l": "2 H2O + 2 O2 + spermine = 2 H2O2 + 2 NH4(+) + spermine dialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6794346", "l": "NRXNs bind NLGNs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67779", "l": "a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H2O <=> a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38756", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30899", "l": "bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052650", "l": "all-trans-retinol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14277", "l": "(S)-lactaldehyde + H2O + NAD(+) = (S)-lactate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.22", "l": "\"lactaldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44592", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72962", "l": "(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) <=> (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54220", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene = all-trans-neurosporene + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042614", "l": "CD70 receptor binding", "d": ["Binding to a CD70, a receptor found on the surface of most activated B cells and some activated T cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106142", "l": "rRNA (adenine-N1-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine(645) in 25S rRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(645) in 25S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76334", "l": "L-aspartate(in) + L-tyrosine(out) <=> L-aspartate(out) + L-tyrosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5387392", "l": "processing defective Hh variants are degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71939", "l": "2-oxoglutarate(out) + 3 Na(+)(out) = 2-oxoglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030280", "l": "structural constituent of skin epidermis", "d": ["The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.1", "l": "\"nitrate reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23252", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047969", "l": "glyoxylate oxidase activity", "d": ["Catalysis of the reaction: glyoxylate + H2O + O2 = H2O2 + H+ + oxalate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15917", "l": "an aldopyranose + NAD(+) = aldono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159773", "l": "Furin cleaves pro-protein S to protein S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507719", "l": "p62:MEKK3 binds to TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5669250", "l": "PAK1 phosphorylates FLNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3238999", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61652", "l": "2,3-dihydroxybenzoate + ATP + holo-[ACP] = 2,3-dihydroxybenzoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.71", "l": "\"2,3-dihydroxybenzoate--[aryl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53653", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417890", "l": "P2Y5 receptor can bind to LPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54483", "l": "1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51260", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] = (10bR,4aS)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008727", "l": "GDP-mannose mannosyl hydrolase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222407", "l": "Superoxide and nitric oxide react to peroxynitrite (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54144", "l": "2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 = 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008113", "l": "peptide-methionine (S)-S-oxide reductase activity", "d": ["Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002466", "l": "Formation of allysine by LOX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322429", "l": "XIAP monoubiquinates TLE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24991", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitroate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61387", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O <=> 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52746", "l": "alpha-isomaltosyl-(1->3)-isomaltose => cyclobis-(1->3)-alpha-D-isomaltosyl + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3238694", "l": "PORCN palmitoleoylates N-glycosyl WNTs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44949", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O => 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61286", "l": "(2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+) => H2O + L-cystine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694527", "l": "Loss of SAR1B GTPase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56070", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432371", "l": "CRY is activated by light and binds to phosphorylated nuclear TIM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876868", "l": "ECE1 cleaves EDN1(53-90) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21852", "l": "(R)-10-hydroxyoctadecanoate = (9Z)-octadecenoate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.53", "l": "\"oleate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74781", "l": "3,3'-O-dimethylmyricetin + H(+) + S-adenosyl-L-homocysteine => laricitrin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380170", "l": "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042263", "l": "neuropeptide F receptor activity", "d": ["Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40997", "l": "4-hydroxybenzaldehyde + acetyl-CoA => 3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3221982", "l": "BANP binds TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63312", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018747", "l": "phenanthrene-1,2-epoxide hydrolase activity", "d": ["Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62587", "l": "ATP + H2O + L-tyrosine(out) <=> ADP + H(+) + L-tyrosine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004436", "l": "phosphatidylinositol diacylglycerol-lyase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804955", "l": "ATM phosphorylates MDM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61400", "l": "ATP + N(6)-(D-ribulosyl)-L-lysine = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811454", "l": "MAPKs phosphorylate PP2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6791235", "l": "GADD45A binds AURKA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16305", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66918", "l": "9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15082", "l": "acetate + ATP + CoA => acetyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56543", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol <=> 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44940", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O = 1-O-alkyl-3-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870461", "l": "RABGGTA and RABGGTB bind (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204549", "l": "Caveolin-1 binds Basigin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31608", "l": "rhodopin => all-trans-lycopene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11572", "l": "FAD + H(+) + H2O + lithocholate = chenodeoxycholate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781941", "l": "WNTs are secreted in exosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443439", "l": "c-Src binds Raf1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55993", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784622", "l": "APOA4,APOA5,APOC2,CIDEC,FGF21 genes express APOA4,APOA5,APOC2,CIDEC,FGF21 proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16931", "l": "2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine => 2 benzoyl-CoA + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080043", "l": "quercetin 3-O-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3-hydroxy group of a quercetin molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57957", "l": "dimethyl sulfoxide + H(+) + NADH + O2 => dimethyl sulfone + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710353", "l": "GSDMD (1-275) binds cardiolipin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64786", "l": "2-aminoprop-2-enoate + ethanethiol => S-ethyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55741", "l": "H2O + oleuropein => D-glucose + oleuropein aglycone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419166", "l": "GEFs activate RhoA,B,C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10717", "l": "D-glucose 6-phosphate => 1D-myo-inositol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9828175", "l": "Formation of the NSL complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034786", "l": "9-fluorenone-3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 9-fluorenone + O2 + 2 H+ + 2 e- = 1-hydro-1,1a-dihydroxy-9-fluorenone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9017491", "l": "RHOJ GEFs activate RHOJ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944265", "l": "Association of procollagen type IV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9853389", "l": "FIGNL1 binds RAD51 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77652", "l": "2 [4-(deca-1,8-diyl)-2,5-dioxo-2,5-dihydro-3-furanyl]acetate + H(+) => 2-[(1R,8S,14R,15R)-11-hydroxy-14,15-bis[(6E)-oct-6-en-1-yl]-3,5,9-trioxo-4,10-dioxatetracyclo[9.4.0.0(2,6).0(8,12)]pentadeca-2(6),12-dien-8-yl]acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17374", "l": "all-trans-antheraxanthin => all-trans-capsanthin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64934", "l": "dGMP + 2 H(+) + 2 phosphate => dGTP + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804100", "l": "HMGB1 binds LPS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627056", "l": "Procaspase 9 forms dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791235", "l": "GADD45A binds AURKA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14160", "l": "H2O + triphosphate <=> diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21425", "l": "3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66235", "l": "IC-asc-C7-CoA + O2 <=> H2O2 + IC-asc-DeltaC7-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247569", "l": "PADI4 deiminates Histones (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35814", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol <=> (-)-medicarpin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74428", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + H(+)(out) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54584", "l": "a guanosine in 18S rRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13936", "l": "all-trans-retinyl hexadecanoate + H2O <=> all-trans-retinol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47455", "l": "(2E,5Z)-tetradecadienoyl-CoA + H2O <=> (3S)-hydroxy-(5Z-tetradecenoyl)-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22481", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+) => 4-nitroquinoline N-oxide + 2 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450387", "l": "HuR binds the CRM1 nuclear export machinery (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64230", "l": "1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45592", "l": "H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102801", "l": "anthocyanin 5-O-glucoside-4'''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: 4'''-demalonylsalvianin + malonyl-CoA = salvianin + coenzyme A."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39177", "l": "(2E)-eicosenoyl-CoA + H2O => (3R)-hydroxyeicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10379", "l": "ATP + Cu(2+)(in) + H2O <=> ADP + Cu(2+)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67461", "l": "(R)-malate + A => AH2 + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45393", "l": "H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691621", "l": "C5 binds C5 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73180", "l": "S-adenosyl-L-methionine + scutellarein => H(+) + S-adenosyl-L-homocysteine + scutellarein 4'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38631", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609743", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3A (GRIN3A) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50863", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70723", "l": "sitosterol(out) = sitosterol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70748", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67473", "l": "H2O + succinyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71181", "l": "FAH cleaves 4FAA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15727", "l": "ascopyrone M + H2O => 1,5-anhydro-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63553", "l": "angiotensin-(1-7) + H2O => angiotensin-(1-5) + L-histidyl-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22751", "l": "4-hydroxy-4-methyl-2-oxoglutarate <=> 2 pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76127", "l": "3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17846", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) => 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64253", "l": "glycine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29662", "l": "O-acetyl-L-serine(in) <=> O-acetyl-L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39244", "l": "(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1011598", "l": "DOCKs bind to RhoGEFs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36308", "l": "(E)-caffeoyl-CoA + H2O => 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75122", "l": "all-trans-13,14-dihydroretinal + H2O + NAD(+) <=> all-trans-13,14-dihydroretinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62839", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70370", "l": "3-oxosphinganine + octanoyl-CoA <=> CoA + H(+) + N-octanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17319", "l": "chlorophyll a + diphosphate => chlorophyllide a + H(+) + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17028", "l": "NADP(+) + xylitol <=> H(+) + L-xylulose + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9734730", "l": "ORC1 translocates to the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18765", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + a sphingomyelin", "d": [], "t": []}, {"i": "EC:2.7.8.27", "l": "\"sphingomyelin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76670", "l": "furfural + H2O + NAD(+) <=> 2-furoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57776", "l": "2-chloro-6-nitrotoluene + NADH + O2 = 4-chloro-3-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033418", "l": "CUC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77517", "l": "(2S)-2-hydroxy-2-(3-methoxyphenyl)acetonitrile => 3-methoxybenzaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75646", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22959", "l": "1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875623", "l": "SLC25A18,22 import L-Glu, H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187678", "l": "ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247840", "l": "WLS binds WNT ligands in the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57853", "l": "a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O => 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-706479", "l": "TAK1 is activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661122", "l": "JMJD6 demethylates Me2R3-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857555", "l": "EGFR phosphorylates GPNMB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451345", "l": "DSCAM binds DCC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28572", "l": "diphosphate + L-seryl-5'-AMP => ATP + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29308", "l": "FMNH2 + methanesulfonate + O2 => FMN + formaldehyde + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66913", "l": "avenanthramide C + S-adenosyl-L-methionine => avenanthramide B + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388503", "l": "Oxytocin receptor bind oxytocin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6804266", "l": "CHEK2 phosphorylates TTC5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57039", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose <=> (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674019", "l": "BRAP binds KSR1:MARK3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5226979", "l": "ADD1:ADD2 binds DMTN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417927", "l": "P2Y2 receptor binds ATP and UTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39182", "l": "(2E)-eicosenoyl-CoA + H(+) + NADPH <=> eicosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70618", "l": "hexadecanoyl-[ACP] + L-lysyl-[protein] <=> H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45680", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in) = N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46969", "l": "A + dihydroisopentenyldehydrorhodopin => AH2 + isopentenyldehydrorhodopin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653957", "l": "Rag dimer formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70947", "l": "L-tryptophan(in) = L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183072", "l": "EGFR non-clathrin mediated endocytosis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612514", "l": "p-S133 CREB and p-S103 SRF bind the EGR1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69665", "l": "beta-D-glucose + luteolin => H2O + luteolin 7-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41926", "l": "(2E)-octadecenoyl-[ACP] + H2O => (3R)-hydroxyoctadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.71", "l": "\"phosphatidyl-N-methylethanolamine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22468", "l": "GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate", "d": [], "t": []}, {"i": "EC:3.5.4.29", "l": "\"GTP cyclohydrolase IIa\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43561", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64275", "l": "benzylamine + pyruvate <=> benzaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11001", "l": "an N-carbamoyl-D-amino acid + 2 H(+) + H2O => a D-alpha-amino acid + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78407", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + sesterfisherol = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + sesterfisherate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.25", "l": "\"vibriolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35051", "l": "N,N'-diacetylchitobiose(out) = N,N'-diacetylchitobiose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169188", "l": "SHP1 (PTPN6) dephosphorylates JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65091", "l": "asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] <=> asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10721", "l": "2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70613", "l": "GOT2 transaminates OA and L-Glu (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41406", "l": "2-methyl-1-pyrroline + H(+) + NADPH => (R)-2-methylpyrrolidine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74856", "l": "dopamine + pyruvate => (R)-salsolinol-1-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.14.-", "l": "\"Protein-arginine kinases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19945", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.201", "l": "\"alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50417", "l": "L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] => H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641229", "l": "TLE oligomerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17000", "l": "3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol <=> 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8934742", "l": "RUNX1 binds PRMT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32627", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38040", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9825783", "l": "p-S207 KARS1 dimer translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62393", "l": "levoglucosan + NAD(+) => 3-dehydrolevoglucosan + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48962", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O => [thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10056", "l": "(3S)-3-aminobutanoyl-CoA = (2E)-butenoyl-CoA + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.14", "l": "\"3-aminobutyryl-CoA ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70281", "l": "D-galactose + raffinose => H2O + stachyose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28908", "l": "3-(3-hydroxyphenyl)propanoate(in) + H(+)(in) => 3-(3-hydroxyphenyl)propanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008157", "l": "protein phosphatase 1 binding", "d": ["Binding to a protein phosphatase 1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791169", "l": "Expression of WFS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76212", "l": "GMP(in) => GMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41580", "l": "5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate = 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.121", "l": "\"5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013009", "l": "RHOA binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64562", "l": "butan-2-one + H(+) + NADH => butan-2-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17764", "l": "an aromatic primary alcohol + NADP(+) <=> an aromatic aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33312", "l": "2 A + hydroxylamine + NH4(+) => 2 AH2 + H(+) + H2O + N2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60059", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 <=> a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44080", "l": "ATP + CoA + undecanoate = AMP + diphosphate + undecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707856", "l": "PGRMC2:Hemes dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18658", "l": "(R)-glycerate + NADP(+) => 3-hydroxypyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11632", "l": "AH2 + L-selenocysteine = A + H(+) + hydrogenselenide + L-alanine", "d": [], "t": []}, {"i": "EC:4.4.1.16", "l": "\"selenocysteine lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65770", "l": "a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793472", "l": "RIPK3 binds p-S9-PRKN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51873", "l": "dimethylallyl diphosphate + umbelliferone => diphosphate + osthenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696605", "l": "USP12, USP26 deubiquitinate AR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28821", "l": "5-dehydro-D-gluconate(out) + H(+)(out) => 5-dehydro-D-gluconate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667914", "l": "ALK binds ligand midkine (MDK) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874685", "l": "CBL binds MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47859", "l": "a ganglioside GD1a (d18:1(4E)) + H2O <=> a ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38729", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210444", "l": "L-Glutamate loading of synaptic vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73836", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate => 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190256", "l": "FGFR1c binds to FGF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40223", "l": "4,8-dimethylnonanoyl-CoA + H2O = 4,8-dimethylnonanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51326", "l": "(8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78193", "l": "a 2-acyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427570", "l": "Group 3 - Selective Cl- transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59735", "l": "biotinyl-5'-AMP + L-lysyl-[protein] <=> AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3229181", "l": "CALM1:Ca2+ binds CNG channel (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111962", "l": "PDE4A,C,D hydrolyse cAMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607751", "l": "TRAF6 oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67991", "l": "N-acetyl-L-glutamine <=> N-acetyl-D-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74972", "l": "L-leucine(out) + L-lysine(in) + Na(+)(out) => L-leucine(in) + L-lysine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54283", "l": "2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428749", "l": "Activated TP receptor binds G-proten Gq (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22317", "l": "13-hydroxydocosanoate + UDP-alpha-D-glucose => 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376140", "l": "Ena/VASP proteins bind ROBO1:SLIT2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989752", "l": "Expression of TXNRD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16024", "l": "oxaloacetate <=> enol-oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168306", "l": "Concerted hemagglutinin pore formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32810", "l": "thiosulfate(in) <=> thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74723", "l": "Endosome acidification (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40838", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O <=> 2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65333", "l": "H(+) + NADPH + O2 + verruculide A => chrodrimanin E + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3321805", "l": "NSL acetylates histone H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78626", "l": "ATP + L-lysyl-5'-AMP <=> L-lysine + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662786", "l": "FURIN cleaves ADAM17 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61472", "l": "a sphingoid base + hexadecanoyl-CoA = an N-hexadecanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.291", "l": "\"sphingoid base N-palmitoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761900", "l": "HBV X protein binds SQSTM1 oligomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433506", "l": "Phosphorylation of APS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36706", "l": "(2S,5S)-5-carboxymethylproline + ATP <=> (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099102", "l": "G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential", "d": ["Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173725", "l": "C9 binds C5b:C6:C7:C8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52085", "l": "13-octadecanoyloxy-octadecanoate + H2O => 13-hydroxy-octadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58513", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46991", "l": "(R)-6-hydroxynicotine + O2 <=> 6-hydroxy-N-methylmyosmine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64172", "l": "L-altrarate = galactarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030768", "l": "16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034559", "l": "bisphenol A hydroxylase B activity", "d": ["Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 1,2-bis(4-hydroxyphenyl)-2-propanol + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13492", "l": "(S)-canadine + H(+) + 2 O2 <=> berberine + 2 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097247", "l": "epigallocatechin 3-gallate binding", "d": ["Binding to epigallocatechin 3-gallate, a compound that is a gallic acid ester of a catechin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869568", "l": "NPM1 binds TFAP2A homodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30291", "l": "(9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}, {"i": "EC:1.13.11.58", "l": "\"linoleate 9S-lipoxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162195", "l": "COQ4 decarboxylates MHDB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194678", "l": "CYP51A1 demethylates LNSOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29844", "l": "ATP + CoA + propanoate => ADP + phosphate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66165", "l": "butanoyl-CoA + serotonin => CoA + H(+) + N-butanoylserotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37275", "l": "H2O + L-alanyl-L-glutamine = L-alanine + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10092", "l": "a 2'-deoxyribonucleoside 3'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.34", "l": "\"deoxynucleotide 3'-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67836", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39153", "l": "(3R)-hydroxyoctadecanoyl-CoA + NADP(+) => 3-oxooctadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198733", "l": "ERK5 is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65454", "l": "CoA + ethyl hexanoate => ethanol + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40821", "l": "(9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63364", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49410", "l": "[(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate => [(1->2)-beta-D-mannosyl](n) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20110", "l": "alpha-D-ribose 1,5-bisphosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785213", "l": "LIPC dimer binds heparin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70027", "l": "N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18001", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.52", "l": "\"phosphatidylinositol deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55879", "l": "apo-[aequorin] + coelenterazine <=> apo-[aequorin]--coelenterazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52342", "l": "AMP + H(+) + long-chain fatty acyl-[mycocerosate synthase] => a long-chain fatty acyl-AMP + holo-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162186", "l": "COQ3 methylates DeMQ10H2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9851407", "l": "FAM83B, (FAM83A, FAM83D) bind EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0030566", "l": "snRNA modification guide activity", "d": ["Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54630", "l": "2-hydroxydodecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + dodecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5580292", "l": "Defective CYP11B1 does not oxidise 11DCORT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58004", "l": "(20S)-ginsenoside F2 + UDP-alpha-D-glucose = (20S)-ginsenoside Rd + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5669250", "l": "PAK1 phosphorylates FLNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65202", "l": "(4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O => S-(acetaldehyde)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75238", "l": "TRAIL binds TRAIL receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25802", "l": "3-acetamidopropanal + H2O2 + spermidine => H2O + N(1)-acetylspermine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37723", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432946", "l": "PARVB/Affixin interacts with alpha PIX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35808", "l": "2-dehydro-3-deoxy-D-arabinonate => 2,5-dioxopentanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140868", "l": "4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)", "d": ["Catalysis of the reaction: 3 H+ + 15-cis-4,4'-diapophytoene + 4 FAD = 4,4'-diapolycopene + 3 FADH2. This reaction consists of three successive dehydrogenations that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'-diapophytofluene and 4,4'-diapo-zeta-carotene as intermediates, and 4,4'-diaponeurosporene (the major deep-yellow pigment in staphylococci strains) as the end product."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196964", "l": "RFK:Mg2+ phosphorylates RIB (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016905", "l": "myosin heavy chain kinase activity", "d": ["Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68960", "l": "DNA polymerase epsilon binds at the origin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701064", "l": "TRPV1 binds TRPV1 agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24352", "l": "ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.279", "l": "\"(R)-3-hydroxyacid-ester dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52917", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29819", "l": "ATP + H2O + L-isoleucine(out) = ADP + H(+) + L-isoleucine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50614", "l": "(2E)-decenal + H(+) + NADPH => decanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78211", "l": "D-leucine + H2O + O2 = 4-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15751", "l": "AH2 + phenylglyoxylate => (S)-mandelate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161964", "l": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63332", "l": "alpha-L-arabinopyanose = beta-L-arabinopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0050786", "l": "RAGE receptor binding", "d": ["Binding to a RAGE receptor, the receptor for advanced glycation end-products."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047269", "l": "poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376145", "l": "SRGAP binds ROBO1:SLIT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167419", "l": "The receptor:G-protein complex releases GDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635102", "l": "GPR161 is internalized (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9823939", "l": "IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944227", "l": "Association of procollagen type XXII (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662617", "l": "MT1G binds cadmium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733207", "l": "p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57344", "l": "3-hydroxy-D-kynurenine + S-adenosyl-L-methionine = 3-hydroxy-4-methyl-D-kynurenine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018459", "l": "carveol dehydrogenase activity", "d": ["Catalysis of the reaction: (1S,5R)-carveol + NADP+ = (R)-carvone + H+ + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047610", "l": "acetylsalicylate deacetylase activity", "d": ["Catalysis of the reaction: acetylsalicylate + H2O = acetate + H+ + salicylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848316", "l": "IL36 binds IL1RL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2471621", "l": "Endostatin degradation by cathepsins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50921", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 => chromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.129", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38127", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol = 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433501", "l": "Interaction of other adapter proteins with p-KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24807", "l": "2-(1-hydroxyethyl)thiamine diphosphate + pyruvate => (2S)-2-acetolactate + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14753", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21451", "l": "16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] <=> 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32042", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate <=> AMP + ATP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712204", "l": "ANO2:Ca2+ translocates Cl- from the cytosol to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59897", "l": "ATP + L-glutamate + L-propargylglycine => ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-377644", "l": "Release of CSK from SRC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928615", "l": "EFNBs bind SFKs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004325", "l": "ferrochelatase activity", "d": ["Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64716", "l": "NADP(+) + propanal = acrolein + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24165", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] => [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050627", "l": "mycothione reductase activity", "d": ["Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445072", "l": "Interaction of PAK1 with Rac1-GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005114", "l": "type II transforming growth factor beta receptor binding", "d": ["Binding to a type II transforming growth factor beta receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690152", "l": "USP5 cleaves polyubiquitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673223", "l": "FIX(29-461) variant is not activated (factor XIa catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41088", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol => 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52589", "l": "choloyl-CoA + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76851", "l": "(S)-sec-butylamine + H2O + NAD(+) = butan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71627", "l": "phosphate(in) + succinate(out) = phosphate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684006", "l": "KPNA2 translocates NBN to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.203", "l": "\"uronate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62767", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47107", "l": "5,10-methylenetetrahydromethanopterin + glycine + H2O <=> 5,6,7,8-tetrahydromethanopterin + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.15", "l": "\"N-sulfoglucosamine-3-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848606", "l": "PTK6 phosphorylates PXN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0051880", "l": "G-quadruplex DNA binding", "d": ["Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40049", "l": "1,2-dioctanoyl-sn-glycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396009", "l": "STING binds c-di-GMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71910", "l": "GDP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-GDP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46699", "l": "a pseudouridine in rRNA + S-adenosyl-L-methionine <=> an N(1)-methylpseudouridine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77009", "l": "AMP + diphosphate + flavunoidine + H(+) => (2S)-5,5-dimethylpiperidine-2-carboxylate + 10-hydroxy-pre-flavunoidine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685608", "l": "CLEC2B binds KLRF1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417829", "l": "P2RY12 binds ADP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38674", "l": "sphinganine 1-phosphate(in) <=> sphinganine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23811", "l": "(S)-scoulerine + S-adenosyl-L-methionine <=> (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191402", "l": "Reduction of presqualene diphosphate to form squalene (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33886", "l": "2-deoxy-scyllo-inosamine + NAD(+) <=> 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42886", "l": "(R)-3-phosphomevalonate + ADP + H(+) => (R)-mevalonate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45671", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60815", "l": "2-oxoglutarate + gibberellin A12 aldehyde + O2 <=> CO2 + gibberellin A12 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622627", "l": "BCL6 gene expression is stimulated by FOXO3,FOXO4,(FOXO1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22985", "l": "carbamoyl phosphate + oxamate => N-carbamoyl-2-oxoglycine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030733", "l": "fatty acid O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9860292", "l": "Activated IKBKB phosphorylates IRF5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617866", "l": "HOXC4 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187828", "l": "Translocation of p21 to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.41", "l": "\"isocitrate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31944", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9696274", "l": "RND1 binds GTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53057", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52800", "l": "acetoacetyl-CoA + ATP + L-isoleucine = AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid", "d": [], "t": []}, {"i": "EC:6.3.2.50", "l": "\"tenuazonic acid synthetase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189439", "l": "ALAD condenses 2 dALAs to form PBG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67090", "l": "ADP + H(+) + phosphate + tetracosanoate(out) => ATP + H2O + tetracosanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686338", "l": "SARS-CoV-1 3a binds the lysosomal membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530429", "l": "Formation of soluble VTN:C5b-C9  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70133", "l": "6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10068", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}, {"i": "EC:2.4.1.53", "l": "\"poly(ribitol-phosphate) beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49980", "l": "H2O + hexanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353314", "l": "XP-C-RAD23B heterodimer binds to damaged DNA site with lesion (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9689680", "l": "IFNG dimer binds IFNG inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72647", "l": "Cap-bound mRNA is activated by helicases  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428231", "l": "ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77748", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacylglycerol => a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58271", "l": "[protein]-C-terminal glycine + NAD(+) <=> [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23319", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 <=> 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.-", "l": "\"Other carbon-oxygen lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047747", "l": "cholate-CoA ligase activity", "d": ["Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. This reaction is the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters. Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388605", "l": "POMC(138-176) binds MC2R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190265", "l": "FGFR4 binds to FGF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63715", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21857", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + H2O => 6-hydroxycyclohex-1-ene-1-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2169046", "l": "Degradation of TGF-beta receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18093", "l": "5,6-dihydrouracil + NADP(+) = H(+) + NADPH + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018798", "l": "RHOV binds GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798474", "l": "S100A8:S100A9 binds Zn2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21576", "l": "carnitine + H(+) = 2-methylcholine + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.42", "l": "\"carnitine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50943", "l": "L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) <=> cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9723906", "l": "Defective TP53 does not tetramerize (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9866272", "l": "2Fe-2S is inserted in UQCRFS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801087", "l": "TP53 binds the RABGGTA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10747", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) <=> 3,4-dihydroxybenzoate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611721", "l": "β1-agonists bind ADRB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52218", "l": "[(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose => [(1''->2')-ADP-alpha-D-ribose](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79074", "l": "(4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside + UDP-alpha-D-glucuronate <=> (4Z,15Z)-bilirubin IXalpha C8,C12-beta-D-bisglucuronoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047407", "l": "ADP-ribosyl-[dinitrogen reductase] hydrolase activity", "d": ["Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30322", "l": "H(+) + NADH + O2 + theobromine <=> 7-methylxanthine + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061928", "l": "glutathione specific gamma-glutamylcyclotransferase activity", "d": ["Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62204", "l": "1-propanol + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.5", "l": "\"exodeoxyribonuclease V\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38564", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + H2O => 1-O-hexadecyl-sn-glycerol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52662", "l": "AMP + an L-alpha-aminoacyl-[ACP] + diphosphate => an L-alpha-amino acid + ATP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57364", "l": "H2O + NADH = (6S)-NADHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79102", "l": "cholate + L-histidine <=> H2O + L-histidocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18529", "l": "3-methylbutanol + NAD(+) = 3-methylbutanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30390", "l": "GDP-alpha-D-glucose + phosphate <=> alpha-D-glucose 1-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-921145", "l": "Activated chicken TAK1 dissociates from the activated TLR3 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31917", "l": "ADP + alpha-maltose 1-phosphate + H(+) => ATP + D-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853496", "l": "SCF:FBXL7 binds AURKA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373751", "l": "UNC-5 binds Netrin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57012", "l": "a menaquinone + H2O + sulfite = a menaquinol + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32691", "l": "(2E)-geranyl diphosphate = (E)-beta-ocimene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.106", "l": "\"(E)-beta-ocimene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14049", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol", "d": [], "t": []}, {"i": "EC:1.14.14.176", "l": "\"taxadiene 5alpha-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31331", "l": "ATP + H(+) + molybdopterin = adenylyl-molybdopterin + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.75", "l": "\"molybdopterin adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10377", "l": "ATP + Cu(2+)(in) + H2O => ADP + Cu(2+)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043802", "l": "hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity", "d": ["Catalysis of the reaction: 2 L-glutamine + 2 ATP + 2 H2O + hydrogenobyrinate = 2 L-glutamate + 2 ADP + 4 H+ + hydrogenobyrinate a,c-diamide + 2 phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39946", "l": "a 1-acylglycerol + an acyl-CoA <=> a 1,2-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41299", "l": "H2O + N-(9Z-octadecenoyl)-sphing-4-enine = (9Z)-octadecenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678998", "l": "Endosomal TLRs pass through the Golgi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36653", "l": "H(+) + novobiocic acid + S-adenosyl-L-homocysteine => 8-desmethylnovobiocic acid + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964471", "l": "DREAM complex binds the CDC25A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33266", "l": "L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.40", "l": "\"pyruvate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201669", "l": "Beta-catenin translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004791", "l": "thioredoxin-disulfide reductase (NADPH) activity", "d": ["Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9716947", "l": "ESR1 binds ESR1 agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13311", "l": "2 H(+) + NADH + vanillate => H2O + NAD(+) + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72895", "l": "2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine = 4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22239", "l": "2-deoxy-D-glucose 6-phosphate + H2O <=> 2-deoxy-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25196", "l": "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) <=> 3-methylcatechol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694441", "l": "CSNK1D phosphorylates SEC23 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74167", "l": "H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin] = formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9017491", "l": "RHOJ GEFs activate RHOJ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38045", "l": "(4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64307", "l": "1-phenylpropylamine + pyruvate <=> 1-phenylpropan-1-one + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73834", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046175", "l": "Further sulfation on galactose residues produces KSPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14342", "l": "2-oxoglutarate + glyoxylate + H(+) => 2-hydroxy-3-oxoadipate + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2172678", "l": "PHF8 demethylates histone H4K20me1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35055", "l": "3,6-dichlorocatechol + O2 = (2E,4E)-2,5-dichloromuconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37014", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043911", "l": "D-lysine transaminase activity", "d": ["Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67463", "l": "(R)-malate + A <=> AH2 + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3221843", "l": "MSR1 (SCARA1) binds collagen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299359", "l": "Activation of TALK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.-", "l": "\"Other oxidoreductases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0031862", "l": "prostanoid receptor binding", "d": ["Binding to a prostanoid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022911", "l": "CSPG is secreted (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36237", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA => 1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57427", "l": "guaiacol + O2 + reduced [NADH--hemoprotein reductase] <=> catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24734", "l": "2-oxoglutarate + 4-hydroxybutanoate = (R)-2-hydroxyglutarate + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647632", "l": "CASP3 cleaves GSDME (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61419", "l": "(S)-8-oxocitronellyl enol <=> cis-trans-nepetalactol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50369", "l": "2-methylbutan-2-ol + H(+) + NADPH + O2 => 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32438", "l": "dihydrocarvone + H(+) + NADPH + O2 <=> 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5251942", "l": "Hikeshi binds HSP70s:ATP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0062186", "l": "anandamide epoxidase activity", "d": ["Catalysis of the epoxidation of double bonds of the arachidonoyl moiety of anandamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004478", "l": "methionine adenosyltransferase activity", "d": ["Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43932", "l": "3beta-hydroxyandrost-5-en-17-one + NAD(+) = androst-5-ene-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399712", "l": "Activation of Ca permeable AMPA receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74038", "l": "D-serine(out) + L-alanine(in) <=> D-serine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68251", "l": "L-tyrosine(in) + Na(+)(in) <=> L-tyrosine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793933", "l": "Expression of MESP2 in presomitic mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25785", "l": "2-dehydro-3-deoxy-L-rhamnonate => (S)-lactaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58750", "l": "H(+) + nectriapyrone + S-adenosyl-L-homocysteine => desmethylnectriapyrone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49931", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54424", "l": "L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44806", "l": "2-demethylmenaquinol-9 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43529", "l": "L-serine + NAD(+) => 2-aminomalonate semialdehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55825", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide d => a bacteriochlorophyllide f + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862771", "l": "PLA2G2A binds bacterial phospholipids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0141057", "l": "histone H3 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl = histone H3 L-citrullyl + NH4+, resulting in histone H3 citrullination."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39214", "l": "(3R)-hydroxyhexacosanoyl-CoA <=> (2E)-hexacosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60878", "l": "a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+) => a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179410", "l": "Association of Nek2A with MCC:APC/C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.616479785166973", "identifiers": [{"i": "GO:0035173", "l": "histone kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42717", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate => (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047716", "l": "imidazole N-acetyltransferase activity", "d": ["Catalysis of the reaction: 1H-imidazole + acetyl-CoA = N-acetylimidazole + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9853376", "l": "FIGNL1 binds SPIDR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5669240", "l": "FLNA binds PAK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66213", "l": "asc-omegaC5-CoA + O2 => asc-omegaDeltaC5-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66023", "l": "H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] <=> [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45220", "l": "coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein] = Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26532", "l": "(2E)-butenoyl-CoA + H2O => 4-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51414", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211983", "l": "CYP2J2 oxidises ARA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33763", "l": "a (2E)-enoyl-CoA + H(+) + NADPH = a 2,3-saturated acyl-CoA + NADP(+)", "d": [], "t": []}, {"i": "EC:1.3.1.38", "l": "\"trans-2-enoyl-CoA reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1912357", "l": "ITCH ubiquitinates DTX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042124", "l": "1,3-beta-glucanosyltransferase activity", "d": ["Catalysis of the splitting and linkage of (1->3)-beta-D-glucan molecules, resulting in (1->3)-beta-D-glucan chain elongation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45668", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53114", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH => 3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24702", "l": "NAD(+) + UDP-alpha-D-glucuronate = CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose", "d": [], "t": []}, {"i": "EC:1.1.1.305", "l": "\"UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16560", "l": "2-amino-3-carboxymuconate 6-semialdehyde + H(+) <=> 2-aminomuconate 6-semialdehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14012", "l": "2 dimethylallyl diphosphate <=> (R,R)-chrysanthemyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099508", "l": "voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "d": ["Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062180", "l": "25-hydroxycholecalciferol-23-hydroxylase activity", "d": ["Catalysis of the reaction: calcidiol + 2 H+ + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]."], "t": []}, {"i": "RHEA:46616", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15899", "l": "4-aminobutanoate + acetate => 4-acetamidobutanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14813", "l": "L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam", "d": [], "t": []}, {"i": "EC:5.1.1.15", "l": "\"2-aminohexano-6-lactam racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67375", "l": "H2O + L-seryl-L-threonine <=> L-serine + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46972", "l": "A + dihydrobisanhydrobacterioruberin = AH2 + bisanhydrobacterioruberin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52869", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate => 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48864", "l": "2-methylpropan-1-amine + FADH2 + O2 = FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78654", "l": "ATP + S-disulfanyl-L-cysteine + tRNA(Cys) <=> (S)-disulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419843", "l": "CALCA(83-119) binds CALCR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30001", "l": "ADP + H(+) + phosphate + spermidine(in) => ATP + H2O + spermidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35864", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102388", "l": "UDP-N,N'-diacetylbacillosamine 2-epimerase activity", "d": ["Catalysis of the reaction: UDP-N,N'-diacetylbacillosamine + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419841", "l": "Light stimulates opsin receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65391", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O <=> a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110219", "l": "Cleavage of thymine by TDG glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008780", "l": "acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity", "d": ["Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61377", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16562", "l": "H2O + squalene => hopan-22-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63406", "l": "6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O => 3,6-dichloropyridine-2,5-diol + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71292", "l": "(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) => (R)-carnitine(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26410", "l": "H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}, {"i": "EC:4.2.1.126", "l": "\"N-acetylmuramic acid 6-phosphate etherase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69589", "l": "inosine + UMP => IMP + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51983", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) <=> an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0031955", "l": "short-chain fatty acid-CoA ligase activity", "d": ["Catalysis of the reaction: a short-chain fatty acid + ATP + CoA = a short-chain fatty acyl-CoA + AMP + diphosphate. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons."], "t": []}, {"i": "RHEA:52860", "l": "a short-chain fatty acid + ATP + CoA = a short-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433374", "l": "Processing of SCF isoform 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25135", "l": "phosphate + pyridoxamine = H2O + pyridoxamine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63912", "l": "6-azauridine + ATP = 6-azauridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69265", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate => an isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71826", "l": "3,3'-diiodo-L-thyronine(out) <=> 3,3'-diiodo-L-thyronine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56908", "l": "(7S)-O-acetylsalutaridinol = acetate + H(+) + thebaine", "d": [], "t": []}, {"i": "EC:4.2.99.24", "l": "\"thebaine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.13", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.12", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67131", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH <=> (1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50924", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.132", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76303", "l": "L-cystine(out) = L-cystine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44886", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+) => a cardiolipin + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.6", "l": "\"leucolysin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693347", "l": "HTR1A binds 5HT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12615", "l": "glutathione disulfide + 2 L-cysteine => 2 glutathione + L-cystine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55512", "l": "cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48676", "l": "6-trans-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-6-trans-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10357", "l": "3alpha-hydroxy-5beta-androstan-17-one + NAD(+) => 5beta-androstane-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35966", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A <=> fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951951", "l": "RUNX3 binds EP300 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9859148", "l": "BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-354060", "l": "Translocation of RIAM to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046575", "l": "rhamnogalacturonan acetylesterase activity", "d": ["Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32637", "l": "(6E)-8-oxolinalool + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53054", "l": "4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxyestrone + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66992", "l": "3-methylpentanoate + ATP + CoA = 3-methylpentanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.9", "l": "\"selenate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47370", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198314", "l": "DAG stimulates protein kinase C-delta (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70328", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) => 4-methylsulfanyl-2-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043724", "l": "2-keto-3-deoxygalactonate aldolase activity", "d": ["Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693575", "l": "DNA-PKcs autophosphorylates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786034", "l": "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38332", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15427", "l": "2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX => coproporphyrinogen III + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51452", "l": "O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate = beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76416", "l": "Benzene is hydroxylated to phenol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64746", "l": "3-sulfanyl-1-hexanol + NH4(+) + pyruvate => H2O + S-3-(hexan-1-ol)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38204", "l": "19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22892", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methenyltetrahydrofolate + NADH", "d": [], "t": []}, {"i": "EC:1.5.1.15", "l": "\"methylenetetrahydrofolate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28316", "l": "baicalin + UDP => baicalein + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17375", "l": "all-trans-capsanthin => all-trans-antheraxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66063", "l": "2-oxohexanoate + L-kynurenine <=> H2O + kynurenate + L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32584", "l": "dihydrocarvone + H(+) + NADPH + O2 => 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18631", "l": "ADP + H(+) + NADP(+) => ATP + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189467", "l": "Cytosolic COPRO3 translocates to mitochondrial intermembrane space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64261", "l": "(9Z,12Z)-octadecadienoyl-CoA + glycine => CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32228", "l": "(6R)-NADPHX => (6S)-NADPHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69463", "l": "[thioredoxin]-dithiol + arsenic triglutathione + 2 H2O + S-adenosyl-L-methionine <=> [thioredoxin]-disulfide + 3 glutathione + H(+) + methylarsonous acid + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36962", "l": "D-ribono-1,4-lactone + H(+) + NADH <=> D-ribose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73089", "l": "AMP(in) + FAD(out) => AMP(out) + FAD(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54670", "l": "alpha-onocerin => pre-alpha-onocerin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818937", "l": "MEN1 binds MLL1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16059", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35208", "l": "H2O + IDP => H(+) + IMP + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48471", "l": "a ganglioside GM1b (d18:1(4E)) + H2O <=> a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13861", "l": "D-xylose + NAD(+) = D-xylono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36412", "l": "7-dehydrocholesterol + hnu => calciol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768945", "l": "NPAS4 stimulates FOS gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16658", "l": "H2O + inosine => D-ribose + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52900", "l": "3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide = 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate", "d": [], "t": []}, {"i": "EC:6.3.3.7", "l": "\"Ni-sirohydrochlorin a,c-diamide reductive cyclase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15579", "l": "D-ribose + uracil => H2O + uridine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54460", "l": "1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51153", "l": "2 a thiol + L-cysteinyl-[sulfatase] + O2 => 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11784", "l": "H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38341", "l": "(20S)-ginsenoside Rd + D-glucose => (20S)-ginsenoside Rb1 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49314", "l": "2-trans-(+)-abscisic aldehyde + H(+) + NADH => 2-trans,4-trans-xanthoxin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19138", "l": "17beta-estradiol + AH2 + O2 => 6beta-hydroxyestradiol-17beta + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.124", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63968", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) = atromentin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66342", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75593", "l": "(11S)-hydroxy-(9S,10S)-epoxy-(12Z)-octadecenoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0015116", "l": "sulfate transmembrane transporter activity", "d": ["Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49427", "l": "ATP + validone <=> ADP + H(+) + validone 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809707", "l": "MTMR12 binds MTMR2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016150", "l": "translation release factor activity, codon nonspecific", "d": ["A translation release factor that is not specific to particular codons; binds to guanine nucleotides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374675", "l": "L1 dimer binds Ankyrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23212", "l": "H2O + N-acetyl-beta-alanine = acetate + beta-alanine", "d": [], "t": []}, {"i": "EC:3.5.1.21", "l": "\"N-acetyl-beta-alanine deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20630", "l": "H2O + O-phospho-L-seryl-[protein] => L-seryl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038057", "l": "TNFSF11 binding", "d": ["Binding to tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047405", "l": "pyrimidine-5'-nucleotide nucleosidase activity", "d": ["Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050273", "l": "S-succinylglutathione hydrolase activity", "d": ["Catalysis of the reaction: S-succinylglutathione + H2O = glutathione + H+ + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113451", "l": "Resumption of RNA Polymerase III Productive Transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607734", "l": "PKC-delta translocates to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1236970", "l": "Proteasomal clevage of exogenous antigen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13240", "l": "D-fructose 6-phosphate + L-glutamine <=> D-glucosamine 6-phosphate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374173", "l": "AGT(34-41) binds to AGTR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0033284", "l": "ATPase-coupled carboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10295", "l": "acetyl-CoA + D-glucosamine 6-phosphate <=> CoA + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28608", "l": "(E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24983", "l": "3-hydroxy-4-methylanthranilate + ATP + H(+) <=> 3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69599", "l": "AMP + inosine <=> adenosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70533", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42389", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose => beta-D-gentiobiosyl crocetin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45664", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0003994", "l": "aconitate hydratase activity", "d": ["Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53029", "l": "lithocholate + UDP-alpha-D-glucuronate => H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37643", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11899", "l": "7alpha-hydroxycholesterol + NAD(+) <=> 7alpha-hydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21190", "l": "AMP + diphosphate + H(+) + NAD(+) => ATP + deamido-NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551648", "l": "SUMOylation of TDG with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5651828", "l": "PARG dePARylates PARP1,PARP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56428", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-901047", "l": "Binding of ERp57 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29621", "l": "alpha-maltopentaose + beta-D-glucose => alpha-maltotetraose + beta-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43405", "l": "N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36822", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111238", "l": "Formation of ADAR2  homodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41675", "l": "1-O-hexadecyl-sn-glycerol + ATP <=> 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21369", "l": "H2O + O2 + urate => 5-hydroxyisourate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46941", "l": "AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] => ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517674", "l": "p-S158,221-HuR binds mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638104", "l": "UGCG transfers glucose to ceramide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67237", "l": "mycophenolyl-CoA + propanoyl-CoA => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22859", "l": "(7S)-salutaridinol + acetyl-CoA <=> (7S)-O-acetylsalutaridinol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43207", "l": "cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418868", "l": "Recruitment of Src and Fyn to DCC:FADK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23139", "l": "a primary amine + S-adenosyl-L-methionine <=> a methylated primary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70873", "l": "L-glutamine(out) + L-valine(in) + Na(+)(in) => L-glutamine(in) + L-valine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72091", "l": "(R)-carnitine(out) + Na(+)(out) = (R)-carnitine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770145", "l": "Formation of the Spliceosomal Bact complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53200", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60840", "l": "a 5'-end diphospho-adenosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] = a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9856718", "l": "HPDL dioxygenates HPPA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2169046", "l": "Degradation of TGF-beta receptor complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10463", "l": "prostaglandin A1 <=> prostaglandin C1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45432", "l": "H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001064", "l": "cellooligosaccharide binding", "d": ["Binding to cellooligosaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168459", "l": "Lyn activates ERK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52902", "l": "15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate => 3 AH2 + ATP + H2O + Ni-sirohydrochlorin a,c-diamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76419", "l": "2-hydroxymethyl-3-pentylphenol + O2 + reduced [NADPH--hemoprotein reductase] = (8S)-annullatin E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11169", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + NAD(+) => 3-oxo-6-carboxyhexanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18641", "l": "a menaquinone + H2 = a menaquinol", "d": [], "t": []}, {"i": "EC:1.12.5.1", "l": "\"hydrogen:quinone oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875443", "l": "USP8 deubiquitinates LRIG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69632", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21266", "l": "AH2 + glyoxylate => A + glycolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50273", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => resolvin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16652", "l": "(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75313", "l": "D-serine(out) + L-alanine(in) + Na(+)(in) => D-serine(in) + L-alanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042301", "l": "phosphate ion binding", "d": ["Binding to a phosphate ion."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76386", "l": "CYP1A2 S-demethylates 6MMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22101", "l": "3,5-dibromo-4-hydroxybenzonitrile + 2 H2O => 3,5-dibromo-4-hydroxybenzoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866269", "l": "ARRB bind GPCRs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29505", "l": "diphosphate + patchoulol => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68517", "l": "(2Z,6Z)-farnesyl diphosphate => beta-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174070", "l": "Association of Cdh1 with the APC/C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029453", "l": "Phosphorylation of VAV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48511", "l": "cholate + NADP(+) <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033964", "l": "glycosphingolipid deacylase activity", "d": ["Catalysis of the hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65619", "l": "A + cholest-4-en-3-one + H2O <=> 25-hydroxycholest-4-en-3-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050391", "l": "valine dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67013", "l": "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62555", "l": "beta-D-glucosylceramide + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.1", "l": "\"CDP-4-dehydro-6-deoxyglucose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21383", "l": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA <=> AMP + diphosphate + phytanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211219", "l": "Translocation of caspase-3 to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10678", "l": "2-isopropylmaleate + H2O => (2R,3S)-3-isopropylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167019", "l": "SHC, complexed with TrkA, is tyrosine-phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050319", "l": "tartrate decarboxylase activity", "d": ["Catalysis of the reaction: L-tartrate + H+ = D-glycerate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168299", "l": "Ribonucleoprotein release from M1 proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54850", "l": "H2O + NADP(+) + propyl propanoate => H(+) + hexan-3-one + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71990", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + fusoxypene C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61778", "l": "H(+) + rebaudioside M + UDP => rebaudioside D + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23737", "l": "5-hydroxyisourate + H2O => 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75612", "l": "H2O + plasmodiophorol A => plasmodiophorol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876789", "l": "CARNMT1 methylates CARN to Anserine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-481010", "l": "Surface deployment of platelet dense granule membrane components (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.550087943541328", "identifiers": [{"i": "GO:0019200", "l": "carbohydrate kinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule."], "t": []}, {"i": "REACT:R-HSA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103036", "l": "NADH:menaquinone oxidoreductase activity", "d": ["Catalysis of the reaction: 5 H+ + NADH + a menaquinone = 4 H+ + NAD + a menaquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56629", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O => chloride + 2 H(+) + maleylacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49426", "l": "ADP + H(+) + validone 7-phosphate => ATP + validone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60082", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+) => 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465941", "l": "A REH hydrolyses 11cRE to 11cROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37294", "l": "H2O + L-alanyl-L-leucine <=> L-alanine + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071208", "l": "histone pre-mRNA DCP binding", "d": ["Binding to the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660663", "l": "Caspase-8 cleaves IL1B precursor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140340", "l": "cerebroside transfer activity", "d": ["Directly binding to a cerebroside and delivering it either to an acceptor molecule or to a specific location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25218", "l": "acetyl-CoA + serotonin => CoA + H(+) + N-acetylserotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944225", "l": "Association of procollagen type XVII (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209973", "l": "Tyrosine is diiodinated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17195", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45611", "l": "H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67263", "l": "(E)-hept-2-enal + H2O + NAD(+) <=> (E)-hept-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373711", "l": "DCC interaction with Netrin-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169192", "l": "PTP1B dephosphorylates GHR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805640", "l": "AKT phosphorylates KAT6A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19399", "l": "CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantothenate + CTP + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41578", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+) => dTDP-beta-L-mycarose + erythronolide B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868118", "l": "MAPK12 phosphorylates PTPN3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18420", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GM3 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47310", "l": "6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77607", "l": "2 3-hexadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-hexadecanoyl-sn-glycero-1-phospho-(3'-hexadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36535", "l": "docosanoyl-CoA + sphinganine = CoA + H(+) + N-docosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008831", "l": "dTDP-4-dehydrorhamnose reductase activity", "d": ["Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034530", "l": "4-hydroxymethylsalicyaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-hydroxymethylsalicylaldehyde + NAD+ + H2O = 4-hydroxymethylsalicylate + NADH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71500", "l": "6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) => 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50807", "l": "glutathione + prostaglandin J2 <=> prostaglandin J2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9860295", "l": "SLC15A4 binds TASL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64212", "l": "an N-(fatty acyl)-L-isoleucine + H2O = a fatty acid + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65882", "l": "5alpha-androstan-1,3,17-trione + AH2 => 1-hydroxy-5alpha-androstan-3,17-dione + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71155", "l": "(E)-caffeoylpyruvate + H2O = (E)-caffeate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102263", "l": "tRNA-dihydrouridine17 synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil17 in tRNA + NAD(P) = H+ + a uracil17 in tRNA + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200858", "l": "Nef Binds and activates the Src-family tyrosine kinase Hck (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640195", "l": "RRAGA,B hydrolyzes GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71146", "l": "3-hydroxyhispidin + O2 <=> (E)-caffeoylpyruvate + CO2 + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250280", "l": "ROS oxidize thioredoxin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59874", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73411", "l": "succinate(in) + sulfate(out) = succinate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40700", "l": "1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol => 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40315", "l": "glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033910", "l": "glucan 1,4-alpha-maltotetraohydrolase activity", "d": ["Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70984", "l": "glycine(out) + n H(+)(in) => glycine(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57075", "l": "3-oxoisoapionate 4-phosphate + H(+) <=> CO2 + L-erythrulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653936", "l": "Formation of Ragulator complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38208", "l": "19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62274", "l": "8 AMP + bassianolide + 8 diphosphate + 8 H(+) + 4 S-adenosyl-L-homocysteine => 4 (R)-2-hydroxy-3-methylbutyrate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29803", "l": "ATP + H2O + L-valine(out) = ADP + H(+) + L-valine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72705", "l": "UDP-alpha-D-galactose(out) + UMP(in) => UDP-alpha-D-galactose(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73596", "l": "dCMP + H2O => dUMP + NH4+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55097", "l": "(3S)-3-hydroxypentanoyl-CoA + H2O => (3S)-3-hydroxypentanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45663", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72438", "l": "(E)-caffeoyl-AMP + CoA <=> (E)-caffeoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102059", "l": "2-cis,6-cis-farnesyl pyrophosphate synthase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + (2Z,6Z)-farnesyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9861642", "l": "NEK1 phosphorylates ME1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735151", "l": "Expression of ISL1 in cardiogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685953", "l": "SIRT6 deacetylates RBBP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65369", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O => a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34163", "l": "hydroquinone + O2 = (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.66", "l": "\"hydroquinone 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66304", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63751", "l": "UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan-2-N-beta-D-glucuronide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120298", "l": "peptide noradrenalinyltransferase activity", "d": ["Catalysis of the reaction: (R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)."], "t": []}, {"i": "RHEA:66560", "l": "(R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022399", "l": "ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70084", "l": "hydroxyclavatol => H2O + o-quinone methide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48290", "l": "a ganglioside GD3 + CMP + H(+) => a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26228", "l": "abieta-7,13-dien-18-al + H2O + NAD(+) <=> abieta-7,13-dien-18-oate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41000", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653957", "l": "Rag dimer formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694661", "l": "TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047631", "l": "ADP-ribose diphosphatase activity", "d": ["Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41245", "l": "N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine => N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855047", "l": "Hydrolysis of internal thioester in C4b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050092", "l": "meso-tartrate dehydrogenase activity", "d": ["Catalysis of the reaction: (2R,3S)-tartrate + NAD+ = dihydroxyfumarate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70044", "l": "6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432067", "l": "Aquaporin-4 passively transports water out of cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49069", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0015159", "l": "polysaccharide transmembrane transporter activity", "d": ["Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661432", "l": "BIL binds ALB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33919", "l": "H(+) + lanosterol + NADPH = 24,25-dihydrolanosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9006873", "l": "IL21 receptor STAT binding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.n1", "l": "\"elongation factor 4\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371527", "l": "HSF1 trimer translocates to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24557", "l": "5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) => 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40737", "l": "2 D-glucose + gypenoside LXXV => (20S)-ginsenoside Rb1 + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174235", "l": "Association of Emi1 with Cdc20 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004772", "l": "sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12692", "l": "2 mycothiol + NAD(+) <=> H(+) + mycothione + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0004177", "l": "aminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050016", "l": "kynurenine 7,8-hydroxylase activity", "d": ["Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54713", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67489", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791107", "l": "Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10764", "l": "(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.73", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0048406", "l": "nerve growth factor binding", "d": ["Binding to nerve growth factor (NGF)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.243", "l": "\"6(G)-fructosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.1", "l": "\"asparaginase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9833635", "l": "p-PKR dimer localizes to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46225", "l": "(E)-feruloyl-CoA + H2O => (E)-ferulate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70440", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2 => a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32920", "l": "H2O + methyl (indol-3-yl)acetate => (indol-3-yl)acetate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69675", "l": "eriodictyol-7-O-beta-D-glucoside + H2O = (S)-eriodictyol + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31785", "l": "diphosphate + tuberculosinol => H2O + tuberculosinyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49319", "l": "beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5R,6S)-5,6-epoxi-beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49729", "l": "2 H(+) + NADPH + 2 O2 + protoviolaceinate => CO2 + 2 H2O + NADP(+) + violacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203613", "l": "depalmitoylation of eNOS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22948", "l": "D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": [], "t": []}, {"i": "EC:4.1.2.40", "l": "\"tagatose-bisphosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42406", "l": "beta-D-glucose + D-galactose 6-phosphate => H2O + lactose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24210", "l": "1,5-anhydro-D-fructose + H(+) + NADPH => 1,5-anhydro-D-mannitol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29584", "l": "guanosine(in) + H(+)(out) => guanosine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74292", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate => an alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25317", "l": "L-2-acetamido-6-oxoheptanedioate + L-glutamate => 2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44770", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2 => 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381435", "l": "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625421", "l": "The anterograde IFT train dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944223", "l": "Association of procollagen type V (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617179", "l": "PRKACA phosphorylates TNNI3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71546", "l": "5-hydroxymethyl-dUMP in DNA + ATP <=> 5-phosphomethyl-dUMP in DNA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38157", "l": "(6E,10E)-geranyllinalool + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21938", "l": "H(+) + N-carbamoylputrescine + phosphate => carbamoyl phosphate + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693198", "l": "RHOD binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357432", "l": "AXL binds SRC-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47417", "l": "an NDP-alpha-D-glucose + D-glucose => a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43983", "l": "H(+) + hexadecanoate + NADPH + O2 <=> 15-hydroxyhexadecanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035798", "l": "2-alkenal reductase (NADPH) activity", "d": ["Catalysis of the reaction: n-alkanal + NADP+ = alk-2-enal + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660663", "l": "Caspase-8 cleaves IL1B precursor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692437", "l": "ANG binds F-actin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42001", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => an isogloboside iGb3Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66425", "l": "ATP + H2O + leukotriene B4(in) => ADP + H(+) + leukotriene B4(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.13", "l": "\"exo-(1->4)-alpha-D-glucan lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169394", "l": "ISGylation of IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69965", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone => 6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981832", "l": "NMUR2 binds neuromedin-S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12478", "l": "formate + L-glutamate => H2O + N-formyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63785", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45534", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine => H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41895", "l": "(3R)-hydroxytetradecanoyl-[ACP] <=> (2E)-tetradecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57205", "l": "glyoxal + L-lysyl-[protein] => N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37278", "l": "H2O + L-alanyl-L-glutamine <=> L-alanine + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74723", "l": "Endosome acidification (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66143", "l": "acetyl-CoA + octopamine <=> CoA + H(+) + N-acetyloctopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16146", "l": "CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57648", "l": "S-adenosyl-L-methionine + trichosetin = equisetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75334", "l": "chloride(out) + D-methionine(out) + 2 Na(+)(out) <=> chloride(in) + D-methionine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796053", "l": "PRKCI phosphorylates NFE2L2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877902", "l": "Activated AR binds RUNX2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57278", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA => a 2'-deoxyguanosine in DNA + glyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051477", "l": "mannosylglycerate transmembrane transporter activity", "d": ["Enables the transfer of a mannosylglycerate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69660", "l": "H2O + kaempferol 3-O-beta-D-glucoside => beta-D-glucose + kaempferol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41030", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39799", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) = 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23654", "l": "N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+) => N-terminal L-glutaminyl-[peptide]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0003747", "l": "translation release factor activity", "d": ["Involved in catalyzing the release of a nascent polypeptide chain from a ribosome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35891", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839405", "l": "InhibinA-TGFBR3 binding to ACVR2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9853385", "l": "PPP1CC dephosphorylates PLK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009045", "l": "xylose isomerase activity", "d": ["Catalysis of the reaction: D-xylose = D-xylulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21305", "l": "ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.441482309351898", "identifiers": [{"i": "GO:0016881", "l": "acid-amino acid ligase activity", "d": ["Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}, {"i": "EC:6.3.2.-", "l": "\"Acid--amino-acid ligases (peptide synthases)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28943", "l": "glycine betaine(in) = glycine betaine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851298", "l": "GPR143 binds L-Dopa (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938887", "l": "PML binds RUNX1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59505", "l": "cholesterol + glycyl-L-cysteinyl-[protein] + H(+) => [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796057", "l": "NFE2L2 dependent AREG expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200406", "l": "CPT1A,B transfers PALM to CAR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654510", "l": "FGFRL1 binds SPRED1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57221", "l": "GTP + methylglyoxal => N(2)-(1-hydroxy-2-oxopropyl)-GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54907", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH <=> (9Z)-hexadecenoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37946", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174445", "l": "RPA binds to the Flap on the C-strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202703", "l": "CD47 binds SIRP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74177", "l": "a ketone + H(+) + NADH + NH4(+) => a secondary alkyl amine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53278", "l": "17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102031", "l": "4-acetamido-4,6-dideoxy-D-galactose transferase activity", "d": ["Catalysis of the reaction: dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-ditrans,polycis-undecaprenol = H+ + alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65549", "l": "a ganglioside Fuc-GM1 + H2O => alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44428", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol = a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11252", "l": "H(+) + hydroxylamine + L-asparagine = beta-L-aspartylhydroxamate + NH4(+)", "d": [], "t": []}, {"i": "EC:2.3.2.7", "l": "\"aspartyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40371", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP = 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.181", "l": "\"polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50778", "l": "(E)-hex-2-enal + H(+) + NADPH => hexanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27666", "l": "(R)-methylmalonyl-CoA + H(+) = CO2 + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61715", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine <=> 2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63120", "l": "(11Z)-eicosenamide + H2O = (11Z)-eicosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396007", "l": "IRF3 is phosphorylated by TBK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31824", "l": "(2E,6E)-farnesyl diphosphate + H2O => cubebol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171291", "l": "Folding and Oligomerization of ENV glycoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15765", "l": "adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19039", "l": "an ethanediol => an epoxide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58349", "l": "2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 => 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937989", "l": "RUNX1 binds PRC1 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75420", "l": "(R,S)-butane-2,3-diol + NAD(+) => (S)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52719", "l": "a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH <=> a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033300", "l": "dehydroascorbic acid transmembrane transporter activity", "d": ["Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004313", "l": "[acyl-carrier-protein] S-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976817", "l": "Formation of serum amyloid P decamer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706319", "l": "Active FLT3 binds to SLA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58958", "l": "a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in RNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809707", "l": "MTMR12 binds MTMR2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22347", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA <=> (R)-rosmarinate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836763", "l": "RSV dsRNA binds TLR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381668", "l": "cAMP activates EPAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50887", "l": "(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O <=> (9Z-octadecenoyl)-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836270", "l": "TFAP2A binds TFAP2C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57900", "l": "2-oxoglutarate + N(6)-methyladenosine in U6 snRNA + O2 = adenosine in U6 snRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17912", "l": "(S)-lactate <=> acetaldehyde + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71212", "l": "chlorate(out) + 2 Na(+)(out) => chlorate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29305", "l": "2 H(+)(out) + succinate(out) => 2 H(+)(in) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354077", "l": "Integrin alphaIIb beta3 activation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70189", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose => alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25012", "l": "N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33967", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O = 3-maleylpyruvate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.91", "l": "\"2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31194", "l": "(3S)-hydroxydecanoyl-CoA <=> (2E)-decenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40147", "l": "eicosanoyl-CoA + H2O = CoA + eicosanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75088", "l": "32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52069", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11772", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.220", "l": "\"6-pyruvoyltetrahydropterin 2'-reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32686", "l": "5-hydroxymethylfurfural + 2 H2O + 3 O2 <=> 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018637", "l": "1-hydroxy-2-naphthoate hydroxylase activity", "d": ["Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NAD(P)H + 2 H+ = NAD(P)+ + H2O + CO2 + 1,2-dihydroxynaphthalene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042609", "l": "CD4 receptor binding", "d": ["Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18908", "l": "H2O + phosphonoacetaldehyde <=> acetaldehyde + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62987", "l": "H2O + hexadecanamide <=> hexadecanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19688", "l": "(E)-feruloyl-CoA + tyramine <=> CoA + H(+) + N-[(E)-feruloyl]tyramine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69116", "l": "Formation of Okazaki fragments (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50411", "l": "1-(2-aminophenyl)decane-1,3-dione <=> 2-heptyl-4(1H)-quinolone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33772", "l": "a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine => 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47131", "l": "ATP + CoA + deoxycholate <=> AMP + deoxycholoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867344", "l": "OMA1 hydrolyses OPA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855232", "l": "RELN:VLDLR binds DAB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43455", "l": "2 H(+) + hexanoyl-CoA + 2 malonyl-CoA <=> 4-hydroxy-6-pentylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71277", "l": "2 Na(+)(in) + taurolithocholate 3-sulfate(in) => 2 Na(+)(out) + taurolithocholate 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72182", "l": "2 Na(+)(out) + tauro-beta-muricholate(out) <=> 2 Na(+)(in) + tauro-beta-muricholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9015111", "l": "Factor Xa inhibitors binds Xa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18928", "l": "L-gulono-1,4-lactone + NADP(+) <=> D-glucurono-3,6-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003921", "l": "GMP synthase activity", "d": ["Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168923", "l": "Collagen type XVIII endostatin release (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296045", "l": "Activation of Potassium transport channels (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689111", "l": "PARK2 autoubiquitinates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635918", "l": "Expression of CEBPB in response to stress (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78052", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acetyl-3-acylglycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35305", "l": "3-oxoisopentadecanoyl-CoA + H(+) + NADPH => 3-hydroxyisopentadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27514", "l": "H2O + sphinganine 1-phosphate = phosphate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24272", "l": "H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138459", "l": "WNT5A:FZD4 is endocytosed (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75891", "l": "Abortive Initiation After Second Transition (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171122", "l": "LDL + LDLR => LDL:LDLR complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56309", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => 1,2-dehydroreticuline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1454916", "l": "The ABCC family mediates organic anion transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72722", "l": "eIF2 activation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1878002", "l": "XYLTs transfer Xyl to core protein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52157", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53080", "l": "4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10192", "l": "ATP + H2O + sulfate(out) = ADP + H(+) + phosphate + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944246", "l": "Association of procollagen type XXI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837625", "l": "hRSV A enters host cell through macropinocytosis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34828", "l": "H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 => H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006507", "l": "GRIN2A gene expression is stimulated by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2995330", "l": "COX10 transforms heme to heme O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78305", "l": "guanine + queuosine(34) in tRNA(Asp) => guanosine(34) in tRNA(Asp) + queuine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35459", "l": "cholesterol + NAD(+) = cholest-5-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21822", "l": "H(+) + L-methionine + S-adenosyl-L-homocysteine => L-homocysteine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52040", "l": "L-cystine = 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67431", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52412", "l": "4-phospho-D-erythronate + NAD(+) = 3-dehydro-4-O-phospho-D-erythronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52396", "l": "4-O-phospho-D-threonate + NAD(+) = CO2 + dihydroxyacetone phosphate + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.408", "l": "\"4-phospho-D-threonate 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29592", "l": "2-hydroxyethane-1-sulfonate + NADP(+) => H(+) + NADPH + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24120", "l": "H(+) + leukotriene E4 + NADPH + O2 = 20-hydroxy-leukotriene E4 + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.34", "l": "\"leukotriene-E4 20-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202328", "l": "Translocation of PKC theta to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672951", "l": "Inactive RAFs bind YWHAB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848395", "l": "IL18:IL18R1 binds IL18RAP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14997", "l": "deoxylimonoate + H2O = deoxylimononate D-ring-lactone + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.46", "l": "\"deoxylimonate A-ring-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002153", "l": "steroid receptor RNA activator RNA binding", "d": ["Binding to a steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801109", "l": "CHM binds RGGT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23515", "l": "alpha,alpha-trehalose + phosphate <=> beta-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42189", "l": "3beta-hydroxy-5alpha-androstan-17-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76685", "l": "ADP + phosphate + sulfoacetyl-CoA => ATP + CoA + sulfoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392749", "l": "Transport of L1 into endosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030762", "l": "tetrahydrocolumbamine 2-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H+ + tetrahydropalmatine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209792", "l": "N-acetylation of serotonin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047057", "l": "vitamin-K-epoxide reductase (warfarin-sensitive) activity", "d": ["Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27814", "l": "acetate(in) + Na(+)(in) = acetate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706312", "l": "Active FLT3 binds to LCK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018831", "l": "5-chloro-1,2,4-trihydroxybenzene dechlorinase activity", "d": ["Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35629", "l": "delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP => delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17188", "l": "IMP + NADP(+) + NH4(+) <=> GMP + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35652", "l": "(4R)-hydroxysphinganine + a fatty acyl-CoA => an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55884", "l": "[aequorin] + 3 Ca(2+) = [aequorin]--dioxetanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061775", "l": "cohesin loader activity", "d": ["Facilitating a conformational change to load a cohesin complex around sister chromatids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086204", "l": "IBSP binds collagen type I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24912", "l": "2-aminobut-2-enoate + L-cysteine => L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.22", "l": "\"pectate trisaccharide-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800816", "l": "TP53 or TP63 stimulates PERP gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645694", "l": "p14ARF binds C1QBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062150", "l": "amorpha-4,11-diene 12-monooxygenase activity", "d": ["Catalysis of the reaction:(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975125", "l": "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18682", "l": "phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine => phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62777", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391942", "l": "IP receptor can bind prostacyclin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018665", "l": "4-hydroxyphenylacetate 1-monooxygenase activity", "d": ["Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106244", "l": "eupatolide synthase activity", "d": ["Catalysis of the reaction: 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932076", "l": "AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158218", "l": "prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781953", "l": "YOD1 binds VCP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427383", "l": "CBX3 (HP1gamma) binds histone H3 dimethylated at lysine-9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730862", "l": "Autophosphorylation of LYN kinase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26317", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate", "d": [], "t": []}, {"i": "EC:4.1.99.20", "l": "\"3-amino-4-hydroxybenzoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75610", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> plasmodiophorol B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937613", "l": "CRHBP binds CRH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607734", "l": "PKC-delta translocates to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218824", "l": "p-6Y-VEGFR2 binds FYN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450387", "l": "HuR binds the CRM1 nuclear export machinery (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23085", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA => 7-methyl-3-oxooct-6-enoyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76614", "l": "H(+) + NADPH + vanillin <=> 4-hydroxy-3-methoxy-benzenemethanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63461", "l": "(2E,6E,10E)-geranylgeraniol + GTP => (2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.34", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62061", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043210", "l": "alkanesulfonate binding", "d": ["Binding to alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47884", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15811", "l": "(R)-linalool + diphosphate => (2E)-geranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939335", "l": "RNF181 polyubiquinates BCL10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55568", "l": "4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine = 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.345", "l": "\"psilocybin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52803", "l": "acetoacetyl-CoA + ATP + L-isoleucine <=> AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023592", "l": "MECP2 binds HTT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44994", "l": "CoA + O-2-methylbutanoyl-(R)-carnitine => (R)-carnitine + 2-methylbutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429441", "l": "SYK activation by SRC (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20471", "l": "D-ribose 5-phosphate + hypoxanthine => H2O + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64988", "l": "CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31589", "l": "(Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+) => FMNH2 + NADH + O2 + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15300", "l": "3-O-(beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33560", "l": "an acyl-CoA + sn-glycerol 3-phosphate => a 2-acyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33582", "l": "NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate <=> H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17230", "l": "acetyl-CoA + an aliphatic alcohol => an acetyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57689", "l": "apo-[corrinoid adenosyltransferase] + cob(II)inamide => cob(II)inamide-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58361", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 => (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47125", "l": "glycine + hexacosanoate => H2O + N-hexacosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68475", "l": "(2Z,6Z)-farnesyl diphosphate <=> (E)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.202618949668349", "identifiers": [{"i": "GO:0016868", "l": "intramolecular phosphotransferase activity", "d": ["Catalysis of the transfer of a phosphate group from one position to another within a single molecule."], "t": []}, {"i": "EC:5.4.2.-", "l": "\"Phosphotransferases (phosphomutases)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.34", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10910", "l": "adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate => 3'-phosphoadenylyl sulfate + glycolithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43498", "l": "H(+) + keto-D-fructuronate + NADH => L-gulonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904678", "l": "alpha-aminoacyl-tRNA binding", "d": ["Binding to an alpha-aminoacyl-tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655170", "l": "RCHY1 monoubiquitinates POLH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44225", "l": "16-hydroxyhexadecanoate + ATP + CoA => 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72907", "l": "D-mannose(out) + Na(+)(out) = D-mannose(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043909", "l": "N-acetylcitrulline deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-L-citrulline + H2O = citrulline + acetate."], "t": []}, {"i": "RHEA:61092", "l": "H2O + N(2)-acetyl-L-citrulline = acetate + L-citrulline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39976", "l": "2-iminobutanoate + H2O => 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40000", "l": "a sphingoid 1-phosphate => a fatty aldehyde + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33095", "l": "chorismate + inosine + phosphoenolpyruvate = futalosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851123", "l": "NPM1-ALK- and p-STAT3-dependent NOTCH gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53223", "l": "16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.33", "l": "\"amylo-alpha-1,6-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827256", "l": "DUX4 binds MaLR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61564", "l": "a tetracycline + H(+) + NADPH + O2 = a (1S,10aS)-3-(CONH2)-1-(Me2N)-3,3a,4,6-(HO)4-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracene + CO + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52295", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141437", "l": "Formation of the MCC complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33285", "l": "6-oxohexanoate + H2O + NADP(+) => 2-hydroxycyclohexan-1-one + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51875", "l": "dimethylallyl diphosphate + umbelliferone <=> diphosphate + osthenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78183", "l": "a 1,2-diacylglycerol + an acyl-CoA = a triacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49459", "l": "(2S)-2-amino-4-deoxychorismate + H2O <=> (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75872", "l": "Conversion of malonyl-CoA and acetyl-CoA to palmitate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72645", "l": "1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine => 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49950", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27608", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42753", "l": "pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33003", "l": "(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] = (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8939201", "l": "ESR dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57333", "l": "H2O + 3 O2 + 3 propionate 3-nitronate => 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985343", "l": "RUNX2 binds SOX9 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.110", "l": "\"aldos-2-ulose dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22217", "l": "(E)-caffeate + O2 => 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27637", "l": "5-dehydro-D-gluconate + NADP(+) <=> 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090583", "l": "protein-phosphocysteine-D-sorbitol-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-sorbitol(out) = protein cysteine + D-sorbitol-1-phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371591", "l": "Trimerization of cytosolic HSF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29796", "l": "ATP(in) + H2O(in) + Zn(2+)(out) => ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730886", "l": "Phosphorylation of SHC by SYK kinase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202459", "l": "Phosphorylation of Bcl10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47439", "l": "(2E,7Z)-hexadecadienoyl-CoA + H2O <=> (3S)-hydroxy-(7Z-hexadecenoyl)-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870346", "l": "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73796", "l": "dimethylallyl diphosphate + neoechinulin A => diphosphate + isoechinulin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709179", "l": "DPP4 binds DPP4 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72397", "l": "2 chloride(in) + K(+)(in) + Na(+)(in) => 2 chloride(out) + K(+)(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693148", "l": "BCKDK phosphorylates BCKDH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45946", "l": "4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA => 12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870469", "l": "RGGT geranylgeranylates RAB proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351948", "l": "Mitochondrial recruitment of Drp1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2984226", "l": "PLK1 phosphorylates NEK9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762343", "l": "PREDL:ALB dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.104", "l": "\"5-phospho-D-xylono-1,4-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29343", "l": "L-aspartate(in) + succinate(out) = L-aspartate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48660", "l": "8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66384", "l": "(2E,6E,10E,14E)-geranylfarnesol = scalar-17(25)-en-19-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944218", "l": "Association of procollagen type VIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34805", "l": "bisdemethoxycurcumin + 2 CO2 + 3 CoA => 2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399930", "l": "Activation of PAK by Rac1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21637", "l": "(E)-4-coumarate + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17365", "l": "ATP + H2O + Mn(2+)(out) = ADP + H(+) + Mn(2+)(in) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.5", "l": "\"ABC-type Mn(2+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62559", "l": "3,4-dihydroxyphenylacetate + H(+) <=> 4-methylcatechol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21394", "l": "2-phenylacetate + 2 H(+) + NADH => 2-phenylacetaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51233", "l": "2-glyceryl-prostaglandin H2 => 2-glyceryl-prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40819", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71041", "l": "L-methionine(out) + L-phenylalanine(in) => L-methionine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.41", "l": "\"riboflavin reductase [NAD(P)H]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798474", "l": "S100A8:S100A9 binds Zn2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102380", "l": "steviolbioside glucosyltransferase activity (rebaudioside B forming)", "d": ["Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = rebaudioside B + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76059", "l": "heliamine + S-adenosyl-L-methionine = H(+) + N-methylheliamine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429036", "l": "SLC2A9 transports Fru, Glc, urate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19428", "l": "H(+) + imidazole-4-acetate + NADH + O2 <=> 5-hydroxyimidazole-4-acetate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265428", "l": "Interaction of integrin alpha9beta1 with VCAM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34509", "l": "N,N-diacetyllegionaminate + phosphate => 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78945", "l": "[DsrC protein]-dithiol + 3 H(+) + NADH + sulfite => [DsrC protein]-trisulfide + 3 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862700", "l": "CMKLR1 binds Resolvin E1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50833", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 => 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69502", "l": "ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide => L-arginyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62471", "l": "3,4-dihydroxybenzoate + ATP + H(+) <=> 3,4-dihydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801166", "l": "TP53 binds the STEAP3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35831", "l": "2-oxoglutarate + kanamycin B + O2 = 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.37", "l": "\"kanamycin B dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008735", "l": "L-carnitine CoA-transferase activity", "d": ["Catalysis of the reactions: (E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4-(trimethylammonio)but-2-enoate + L-carnitinyl-CoA and 4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373713", "l": "DCC heterodimerizes with UNC-5:Netrin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865605", "l": "BRWD1 binds SMARCA4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61477", "l": "a sphingoid base + octadecanoyl-CoA => an N-octadecanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57274", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA => a 2'-deoxyguanosine in DNA + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67610", "l": "diphosphate + H(+) + N(6)-methyl-AMP => H2O + N(6)-methyl-ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67688", "l": "2,6,10,14-tetramethylpentadecanoate(in) + ATP + H2O = 2,6,10,14-tetramethylpentadecanoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42298", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP] => a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201608", "l": "Caspase-mediated cleavage of alpha adducin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47939", "l": "4-hydroxybenzaldehyde + H2O + NADP(+) <=> 4-hydroxybenzoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14872", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445083", "l": "CHL1 interacts with NRP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60320", "l": "N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017020", "l": "myosin phosphatase regulator activity", "d": ["Binds to and modulates of the activity of myosin phosphatase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43618", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate => [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066782", "l": "Translocation of DPA to the ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15548", "l": "(3S)-citramalate <=> acetate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018676", "l": "(S)-limonene 7-monooxygenase activity", "d": ["Catalysis of the reaction: (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5195402", "l": "CDK1 phosphorylates LPIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193665", "l": "MYD88 dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9856502", "l": "mito-STARD7 transports Q10 to outer mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24872", "l": "5'-deoxyadenosine + phosphate <=> 5-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446634", "l": "IRAK4 is activated by autophosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032843", "l": "hydroperoxide reductase activity", "d": ["Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14693", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = a dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.153", "l": "\"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76183", "l": "2 H(+)(out) + L-alanyl-L-alanine(out) = 2 H(+)(in) + L-alanyl-L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378975", "l": "Follitropin is a heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873927", "l": "Release of STAT1 dimer from active receptor unit (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018524", "l": "acetophenone carboxylase activity", "d": ["Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76635", "l": "n H(+)(out) + Mn(2+)(in) = n H(+)(in) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662606", "l": "MT3 binds zinc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17267", "l": "cis-aconitate => trans-aconitate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168888", "l": "Alpha1-Microglobulin binds heme (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39546", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78980", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => bonnadiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28208", "l": "ADP + dUMP + H(+) => 2'-deoxyuridine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78891", "l": "6-O-methyl-N-deacetylisoipecoside + H2O = 6-O-methyl-N-deacetylisoipecoside aglycone + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42711", "l": "guanosine(46) in tRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222237", "l": "SMYD2 methylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71655", "l": "an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O = a thymidine in DNA + ADP-D-ribose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202731", "l": "JAM3 dimerises (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46384", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 24S,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54926", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + CO2 + holo-[ACP] => (7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27540", "l": "4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde => ethanol + N,N-dimethyl-4-nitrosoaniline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47211", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n7", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23091", "l": "ATP + O-alkylglycerone <=> 1-O-alkylglycerone 3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.12", "l": "\"ABC-type capsular-polysaccharide transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805470", "l": "AMPK phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76980", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5334827", "l": "SUMO-CRABP2 binds atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842665", "l": "Active LTK binds GRB2:TNK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41916", "l": "H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32669", "l": "H(+) + hydrogen sulfide + methyl-coenzyme M => coenzyme M + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42158", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) => androsterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65298", "l": "ethylacryloyl-CoA + reduced [electron-transfer flavoprotein] => (2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71371", "l": "epitestosterone 17-sulfate(out) + 2 Na(+)(out) = epitestosterone 17-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59607", "l": "H2O + O2 + spermidine <=> H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49774", "l": "CoA + H(+) + N-hexacosanoylglycine => glycine + hexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20716", "l": "H(+) + H2O + S-adenosyl-L-homocysteine = NH4(+) + S-inosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:3.5.4.28", "l": "\"S-adenosylhomocysteine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23629", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391933", "l": "EP3 receptor can bind PGE2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9709547", "l": "ESTG binds ESR2:chaperone complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.77", "l": "\"protein-L-isoaspartate(D-aspartate) O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65832", "l": "AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O = A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23025", "l": "[(1->4)-beta-D-glucosyl](n) + phosphate => [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45244", "l": "(3E,5Z)-octadienoyl-CoA = (2E,4E)-octadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2214324", "l": "Collagen type VII dimerization (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40042", "l": "2 ATP + 2 L-glutamate + N-acetyl-L-aspartate <=> 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875374", "l": "MET binds LRIG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195275", "l": "Phosphorylation of APC component of the destruction complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200406", "l": "CPT1A,B transfers PALM to CAR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61505", "l": "pelargonidin + UDP-alpha-D-glucose => pelargonidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62460", "l": "3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.62", "l": "\"3,4-dihydroxybenzoate--[aryl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51487", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953013", "l": "E2F7 binds E2F8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44505", "l": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate => a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694522", "l": "Inner coat assembly and cargo binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53533", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38579", "l": "dammarenediol-II + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-protopanaxadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.120", "l": "\"dammarenediol 12-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050304", "l": "nitrous-oxide reductase activity", "d": ["Catalysis of the reaction: H2O + 2 cytochrome c + nitrogen = 2 reduced cytochrome c + nitrous oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66072", "l": "4-methyl-2-oxopentanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222237", "l": "SMYD2 methylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1497810", "l": "Uncoupled eNOS favours the formation of superoxide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37960", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.31", "l": "\"DNA nucleotidylexotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45576", "l": "(2R)-ethylmalonyl-CoA = (2S)-methylsuccinyl-CoA", "d": [], "t": []}, {"i": "EC:5.4.99.63", "l": "\"ethylmalonyl-CoA mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19558", "l": "AH2 + O2 + pregna-4,9(11)-diene-3,20-dione => 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784765", "l": "p-Y705-STAT3 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46892", "l": "2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.109", "l": "\"8-amino-3,8-dideoxy-alpha-D-manno-octulosonate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19313", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.3.8", "l": "\"alpha-N-acetylneuraminate alpha-2,8-sialyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34341", "l": "(20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => (22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868236", "l": "BAR domain proteins recruit dynamin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018799", "l": "4-hydroxybenzoate decarboxylase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + H+ = CO2 + phenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660662", "l": "ASC binds Caspase-8 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672083", "l": "KTN1 binds Kinesin-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.7", "l": "\"Glu-Glu dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54219", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 <=> 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392206", "l": "G alpha (i) inhibits adenylate cyclase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032560", "l": "guanyl deoxyribonucleotide binding", "d": ["Binding to a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35911", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59240", "l": "L-arginine + L-lysine = L-homoarginine + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0009039", "l": "urease activity", "d": ["Catalysis of the reaction: urea + H2O = CO2 + 2 NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59616", "l": "beta-alanyl-L-arginine + H2O = beta-alanine + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17874", "l": "an R-cob(III)alamin(out) + ATP + H2O => ADP + an R-cob(III)alamin(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106329", "l": "L-phenylalaine oxidase activity", "d": ["Catalysis of the reaction: H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+)."], "t": []}, {"i": "RHEA:61240", "l": "H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863494", "l": "ASICs bind STOML3, (STOM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614271", "l": "Autocleavage of ADGRG6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0017110", "l": "nucleoside diphosphate phosphatase activity", "d": ["Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14085", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA = 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032532", "l": "NTRK2-bound FYN autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031683", "l": "G-protein beta/gamma-subunit complex binding", "d": ["Binding to a complex of G-protein beta/gamma subunits."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30996", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58693", "l": "FADH2-C4alpha-hydroperoxide + H(+) + NADH + rifamycin SV => FADH2 + H2O + NAD(+) + rifamycin SV hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390912", "l": "HRH1 binds hist (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851888", "l": "MET binds SHC1-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43073", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => erythrodiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3245898", "l": "TCN1 binds correnoids in the circulation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372448", "l": "SLC25A12,13 exchange L-Glu and L-Asp (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55373", "l": "H2O + methyl (-)-jasmonate => H(+) + jasmonate + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215406", "l": "PRMT5 binds WDR77 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30895", "l": "H2O + O2 + propane-1,3-diamine = 3-aminopropanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25863", "l": "GTP + H2O <=> 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21366", "l": "2 6-aminohexanoate => H2O + N-(6-aminohexanoyl)-6-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043840", "l": "branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity", "d": ["Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34216", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) => 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31328", "l": "1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol => bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29563", "l": "ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": [], "t": []}, {"i": "EC:6.3.2.45", "l": "\"UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67926", "l": "3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP => 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203567", "l": "palmitoylation of eNOS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9861660", "l": "ME1 tetramer decarboxylates OA to PYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35746", "l": "H(+) + NADPH + O2 + versicolorin B <=> 2 H2O + NADP(+) + versicolorin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73918", "l": "acetyl-CoA + 4 H(+) + 6 malonyl-CoA <=> 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + 6 CO2 + 7 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38484", "l": "a 2,3-diacyl-sn-glycerol + H2O => a 2-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198756", "l": "ERK1/2 phosphorylates MSK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78219", "l": "D-arginine + H2O + O2 = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45972", "l": "3-oxochol-4-en-22-oate + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57372", "l": "H2O + NADPH = (6S)-NADPHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56414", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50015", "l": "H(+) + NADPH + O2 + tert-butanol <=> 2-methylpropane-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20971", "l": "L-arabinonate <=> 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36924", "l": "(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380311", "l": "Recruitment of Plk1 to centrosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53842", "l": "7,12-dioxo-lithocholate + H(+) + NADPH => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72782", "l": "chloride + FADH2 + O2 + ochratoxin B <=> FAD + 2 H2O + ochratoxin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031721", "l": "hemoglobin alpha binding", "d": ["Binding to a hemoglobin alpha chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794444", "l": "ALB binds Cipro (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684169", "l": "G6B binds PTPN6,PTPN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46807", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine <=> a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66368", "l": "6-methyl-3,7-dioxodecanedioyl-CoA + CoA = 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73601", "l": "CDP(out) + CTP(in) => CDP(in) + CTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140751", "l": "histone octamer slider activity", "d": ["A chromatin remodeler activity that slides core histone octamers along chromosomal DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682010", "l": "ATG10:ATG12 binds ATG5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21936", "l": "carbamoyl phosphate + putrescine = H(+) + N-carbamoylputrescine + phosphate", "d": [], "t": []}, {"i": "EC:2.1.3.6", "l": "\"putrescine carbamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047768", "l": "carboxy-cis,cis-muconate cyclase activity", "d": ["Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202127", "l": "eNOS synthesizes NO (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74357", "l": "a uridine in mRNA + NH4(+) => a cytidine in mRNA + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68975", "l": "A + sn-glycerol 3-phosphate <=> AH2 + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60709", "l": "(1R,3R)-chrysanthemal + H2O + NAD(+) => (1R,3R)-chrysanthemate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26222", "l": "abieta-7,13-dien-18-ol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-oate + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59424", "l": "benzylamine + H2O + O2 = benzaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015421", "l": "ABC-type oligopeptide transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21042", "l": "CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183051", "l": "CBL ubiquitinates Sprouty (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62433", "l": "a uridine in tRNA + S-adenosyl-L-methionine => a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050305", "l": "strombine dehydrogenase activity", "d": ["Catalysis of the reaction: N-(carboxymethyl)-D-alanine + H2O + NAD+ = glycine + H+ + NADH + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77937", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58778", "l": "H(+) + NADPH + pyridine-3-carbaldehyde => NADP(+) + pyridine 3-methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56375", "l": "3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 <=> 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102786", "l": "stearoyl-[acp] desaturase activity", "d": ["Catalysis of the reaction: O2 + a stearoyl-[acp] + a reduced ferredoxin = 2 H2O + an oleoyl-[acp] + an oxidized ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211924", "l": "CYP4B1 12-hydroxylates ARA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13469", "l": "A + H2O + thymine = 5-methylbarbiturate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433845", "l": "chicken RIP1 facilitates IKKs complex activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749197", "l": "ORC1 binds to H4K20me2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28348", "l": "7,8-dihydromonapterin 3'-triphosphate => 7,8-dihydroneopterin 3'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51175", "l": "cytidine(62) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(62) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37296", "l": "ATP + H2O + L-alanyl-L-threonine(out) => ADP + H(+) + L-alanyl-L-threonine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112690", "l": "PTPN11 binds CBL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28515", "l": "(R)-carnitine + ATP + CoA => (R)-carnitinyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34707", "l": "AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane", "d": [], "t": []}, {"i": "EC:4.7.1.1", "l": "\"alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879459", "l": "F-actin capping protein is a heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68844", "l": "(2Z,6E)-farnesyl diphosphate = (Z)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389026", "l": "Galanin receptors can bind galanin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22569", "l": "ascopyrone M => ascopyrone P", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008720", "l": "D-lactate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-lactate + NAD+ = H+ + NADH + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40179", "l": "decanoyl-CoA + O2 = (2E)-decenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46247", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65666", "l": "citrate(in) + 4 Na(+)(in) => citrate(out) + 4 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22187", "l": "(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) <=> acenaphthene-1,2-dione + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.17", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49388", "l": "UDP-alpha-D-glucose + validoxylamine A = H(+) + UDP + validamycin A", "d": [], "t": []}, {"i": "EC:2.4.1.338", "l": "\"validoxylamine A glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9858752", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74597", "l": "mesaconate + NH4(+) => (2S,3R)-3-methyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090554", "l": "phosphatidylcholine floppase activity", "d": ["Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}, {"i": "RHEA:38583", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21135", "l": "H2O + O2 + xanthine <=> H2O2 + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18665", "l": "(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) = (2R)-3-phosphoglycerate + [phosphate](n+1)", "d": [], "t": []}, {"i": "EC:2.7.4.17", "l": "\"3-phosphoglyceroyl-phosphate--polyphosphate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60016", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sesquisabinene B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40497", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34295", "l": "2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose = 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912391", "l": "NICD1 is phosphorylated by CDK8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71087", "l": "17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38693", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77426", "l": "cyclohexanecarbaldehyde + hydrogen cyanide <=> (2S)-2-cyclohexyl-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-419166", "l": "GEFs activate RhoA,B,C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33610", "l": "(9Z)-octadecenoate + ATP + CoA <=> (9Z)-octadecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018731", "l": "1-oxa-2-oxocycloheptane lactonase activity", "d": ["Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52323", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryptamine <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61679", "l": "holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP <=> AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070282", "l": "pyridoxine binding", "d": ["Binding to pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56969", "l": "dCTP + pyruvate => dCDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9015111", "l": "Factor Xa inhibitors binds Xa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62536", "l": "digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigoxigenin + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52182", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75697", "l": "2'-deoxycytidine(out) => 2'-deoxycytidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52979", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981443", "l": "CIT-3 binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22905", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] => gibberellin A12 aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27512", "l": "dehydro coenzyme F420-0 + GMP + H(+) => 7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49981", "l": "H2O + hexanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50281", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 => (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43341", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] => [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963913", "l": "1,25(OH)2D translocates from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727607", "l": "MME:Zn2+ binds sacubitrilat (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35549", "l": "2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin] => cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022065", "l": "DSPGs are secreted (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41730", "l": "18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41387", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24251", "l": "glyoxylate + L-alanine <=> glycine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690152", "l": "USP5 cleaves polyubiquitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033792", "l": "3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase activity", "d": ["Catalysis of the reactions: a 3alpha-hydroxy bile acid CoA + NAD+ = a 3-oxo bile acid CoA + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.88", "l": "\"non-reducing end beta-L-arabinopyranosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62600", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9679044", "l": "FKBP1A binds sirolimus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9846305", "l": "ST6GALNAC5,6 transfer Neu5Ac to GM1b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12979", "l": "creatine + phosphate => H2O + N-phosphocreatine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161907", "l": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46491", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73457", "l": "8-hydroxysalvigenin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + salvigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53947", "l": "2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) <=> (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72024", "l": "nicotinate(in) + urate(out) => nicotinate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17970", "l": "ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76125", "l": "a dicarboxylate(out) + prostaglandin E2(in) => a dicarboxylate(in) + prostaglandin E2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008574", "l": "plus-end-directed microtubule motor activity", "d": ["A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73399", "l": "D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57224", "l": "glyoxal + GTP = N(2)-(1-hydroxy-2-oxoethyl)-GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50551", "l": "prostaglandin E1 <=> H2O + prostaglandin A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33283", "l": "2-hydroxycyclohexan-1-one + NADPH + O2 = 6-oxohexanoate + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.66", "l": "\"2-hydroxycyclohexanone 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58617", "l": "N-octanoyl-(2S)-hydroxyglycine => glyoxylate + octanamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17853", "l": "keto-L-sorbose + O2 = 5-dehydro-D-fructose + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.11", "l": "\"L-sorbose oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627078", "l": "XIAP binds CASP9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140968", "l": "polyspecific organic cation:proton antiporter activity", "d": ["Enables the transfer of various organic cations in exchange for a proton, according to the reaction: H+(out) + organic cation(in) = H+(in) + organic cation(out). The transported substrates are usually toxic molecules, drugs and xenobiotics."], "t": []}, {"i": "TCDB:2.A.66.1.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68216", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol = 1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685156", "l": "ATR phosphorylates RPA2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61542", "l": "ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687388", "l": "SARS-CoV-1 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49462", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+) => (2Z,4E)-2-aminomuconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10855", "l": "dimethylallyl diphosphate + leachianone G <=> diphosphate + sophoraflavanone G", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19781", "l": "2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.24", "l": "\"diiodotyrosine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9660557", "l": "RAS:GTP binds RAL GDS proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618586", "l": "E2F1 binds the promoter of the MYC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47484", "l": "deoxycholate + NAD(+) = 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59937", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45255", "l": "tetradecanoate(out) <=> tetradecanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41556", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.47", "l": "\"[50S ribosomal protein L16]-arginine 3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417908", "l": "P2RY1 binds ADP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047835", "l": "D-tryptophan N-acetyltransferase activity", "d": ["Catalysis of the reaction: D-tryptophan + acetyl-CoA = N-acetyl-D-tryptophan + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41231", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61323", "l": "(+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18725", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9838093", "l": "LONP1 binds mitochondrial matrix proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46829", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45716", "l": "H2O + N,N,N-trimethylglycyl-CoA = CoA + glycine betaine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428664", "l": "SGPP1,2 dephosphorylate sphingoid-1-phosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5658435", "l": "RAS GAPs bind RAS:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65655", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine <=> a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71026", "l": "L-leucine(in) + L-phenylalanine(out) <=> L-leucine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19196", "l": "A + all-trans-13,14-dihydroretinol <=> AH2 + all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70829", "l": "L-arginine(out) + L-lysine(in) => L-arginine(in) + L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10659", "l": "guanidinoacetate + S-adenosyl-L-methionine <=> creatine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37772", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.64", "l": "\"3-demethylubiquinol 3-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15003", "l": "5-dehydro-D-fructose + H(+) + NADPH => keto-L-sorbose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77258", "l": "beta-D-glucosylceramide(in) <=> beta-D-glucosylceramide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30641", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+) => (R)-glycerate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69856", "l": "a 5,6-dihydrouridine in mRNA + NADP(+) => a uridine in mRNA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.8", "l": "\"protein-disulfide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78737", "l": "3-oxotetracosanoyl-CoA + H(+) + NADH => (3S)-hydroxytetracosanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6813749", "l": "ALDH1A1 oxidises GA to DGA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74557", "l": "(S)-malate(in) => (S)-malate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39453", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O => (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033770", "l": "2-hydroxyisoflavanone synthase activity", "d": ["Catalysis of the reactions: liquiritigenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',7-trihydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase] and (2S)-naringenin + O2 + [reduced NADPH--hemoprotein reductase] = 2,4',5,7-tetrahydroxyisoflavanone + H2O + [oxidized NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964284", "l": "BTK in active Gq-BTK complex is activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.258", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatE\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32572", "l": "(E)-2-methylgeranyl diphosphate + H2O => 2-methylisoborneol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71936", "l": "glycocholate(out) + 2 Na(+)(out) => glycocholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033820", "l": "DNA alpha-glucosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047320", "l": "D-4-hydroxyphenylglycine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050585", "l": "4-hydroxymandelate synthase activity", "d": ["Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28827", "l": "L-ornithine(out) + putrescine(in) = L-ornithine(in) + putrescine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24383", "l": "(6R)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614591", "l": "Excess cysteine yields lanthionine and H2S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64500", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine = 3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70454", "l": "2-oxoglutarate + an N(1)-ethyl-2'-deoxyadenosine in single-stranded DNA + O2 <=> a 2'-deoxyadenosine in single-stranded DNA + acetaldehyde + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68187", "l": "a medium-chain fatty acyl-CoA + H2O <=> a medium chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46322", "l": "3beta-hydroxy-chol-5,22-dien-24-oyl-CoA + AH2 => 3beta-hydroxy-chol-5-ene-24-oyl-CoA + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24666", "l": "H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide => 2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112604", "l": "Phosphorylated STATs are released (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164616", "l": "Biogenesis and assembly of the telomerase RNP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19738", "l": "4-(gamma-L-glutamylamino)butanoate + H2O => 4-aminobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26563", "l": "2-succinylbenzoyl-CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382058", "l": "Nck binds to the active PDGF receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015367", "l": "oxoglutarate:malate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21659", "l": "CDP-alpha-D-paratose <=> CDP-3,6-dideoxy-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700168", "l": "Active ALK phosphorylates IRS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54297", "l": "GTP + L-tyrosyl-[protein] => diphosphate + O-(5'-guanylyl)-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66189", "l": "3',5'-cyclic GMP(in) + ATP + H2O => 3',5'-cyclic GMP(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49773", "l": "glycine + hexacosanoyl-CoA => CoA + H(+) + N-hexacosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29510", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-gurjunene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250220", "l": "Homodimerization of ERBB4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18092", "l": "H2O + L-arginyl-[protein] <=> L-citrullyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434989", "l": "SEMA7A binds to PLXNC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71751", "l": "2-oxoglutarate(out) + glutarate(in) = 2-oxoglutarate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635843", "l": "GLI translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.20", "l": "\"peptidyl-Lys metalloendopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37095", "l": "(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(12Z,15Z,18Z,21Z)-tetracosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36974", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833436", "l": "RSV N binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16910", "l": "2 Fe(III)-[cytochrome c] + glycine + H2O => 2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74640", "l": "AMP(out) + CMP-N-acetyl-beta-neuraminate(in) => AMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61309", "l": "(+)-(R)-germacrene A + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71162", "l": "H(+)(in) + L-serine(out) + Na(+)(out) <=> H(+)(out) + L-serine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12027", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + choline <=> D-glucose + O-sinapoylcholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54017", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72724", "l": "UDP-alpha-D-xylose(in) + UMP(out) => UDP-alpha-D-xylose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018450", "l": "myrtenol dehydrogenase activity", "d": ["Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52475", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132269", "l": "Formation of classical C5 convertase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254291", "l": "ERBB4s80 binds STAT5A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052588", "l": "diacetyl reductase ((S)-acetoin forming) activity", "d": ["Catalysis of the reaction: (S)-acetoin + NAD+ = diacetyl + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57772", "l": "3-nitrotoluene + NADH + O2 = 4-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12946", "l": "2'-hydroxybiphenyl-2-sulfinate + H2O => biphenyl-2-ol + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15266", "l": "1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate => H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450054", "l": "Interleukin-2 receptor alpha binds interleukin-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019978", "l": "interleukin-3 binding", "d": ["Binding to interleukin-3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162253", "l": "PDSS1,2 ligates FPP to IPPP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56653", "l": "12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38740", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174427", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62225", "l": "H(+) + NADPH + neopatulin => (E)-ascladiol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689649", "l": "BAP1 binds BRCA1:BARD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417898", "l": "P2Y4 receptor can bind to UTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49155", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine <=> dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507875", "l": "Aquaporins passively transport urea into cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52503", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (13R)-hydroxy-(9Z,11E)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102363", "l": "isoscopoletin-O-methyltransferase activity", "d": ["Catalysis of the reaction: isoscopoletin + S-adenosyl-L-methionine = scoparone + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-167429", "l": "The receptor:G-protein complex  binds GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191656", "l": "Closure of gap junction (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61595", "l": "H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine <=> 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17469", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]", "d": [], "t": []}, {"i": "EC:2.3.1.135", "l": "\"phosphatidylcholine--retinol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655343", "l": "Activated FGFR2 mutants bind PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694524", "l": "nsp13 binds nsp12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.270", "l": "\"3beta-hydroxysteroid 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373707", "l": "Netrin-1 induced DCC clustering (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856398", "l": "NPTN binds GABA A receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168915", "l": "K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.286", "l": "\"chalcone 4'-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043743", "l": "LPPG:FO 2-phospho-L-lactate transferase activity", "d": ["Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75199", "l": "H2O + triuret = 1-carboxybiuret + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71426", "l": "3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) <=> 3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50322", "l": "1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24780", "l": "C-13(2)-carboxypyropheophorbide a + H(+) = CO2 + pyropheophorbide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17068", "l": "(R)-mevalonate + ATP <=> (R)-5-phosphomevalonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216043", "l": "Collagen type II binds integrin alpha10beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5444511", "l": "Formation of MSH2:MSH3 Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038164", "l": "thrombopoietin receptor activity", "d": ["Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928576", "l": "RHOA:GTP binds ROCK, activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66147", "l": "5-methoxytryptamine + acetyl-CoA <=> CoA + H(+) + melatonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38628", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA => 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63450", "l": "CMP-(2-aminoethyl)phosphonate + diphosphate => (2-aminoethyl)phosphonate + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193684", "l": "p62 recruits an atypical PKC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77609", "l": "Binding of APOBEC-1 to form editosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71435", "l": "an aromatic L-alpha-amino acid(in) + L-thyroxine(out) = an aromatic L-alpha-amino acid(out) + L-thyroxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21066", "l": "[protein]-dithiol + glutathione disulfide => [protein]-disulfide + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0005516", "l": "calmodulin binding", "d": ["Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004413", "l": "homoserine kinase activity", "d": ["Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20616", "l": "3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine <=> adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23819", "l": "2-oxoglutarate + putrescine <=> 4-aminobutanal + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41646", "l": "2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + AMP + diphosphate => 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72083", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O = ADP-alpha-D-ribose 1''-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38991", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48842", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58337", "l": "a 4-hydroxynonen-1-ol + NADP(+) => a 4-hydroxynonenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54775", "l": "ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide <=> 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26054", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034574", "l": "didemethylisoproturon dehydrogenase activity", "d": ["Catalysis of the reaction: didemethylisoproturon + H2O = 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018585", "l": "fluorene oxygenase activity", "d": ["Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173723", "l": "C8 binds C5b:C6:C7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34593", "l": "Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-7 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191999", "l": "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173709", "l": "C7 binds C5b:C6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021596", "l": "Membrane estrogen receptors bind SRC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465924", "l": "OPN1LW binds 11cRAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46220", "l": "androst-5-en-3beta,17beta-diol + NAD(+) = 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73319", "l": "(2R,3S)-piscidate + (E)-4-coumaroyl-CoA = cimicifugate K + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671707", "l": "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29486", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-beta-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33698", "l": "C20 sphinganine + NADP(+) <=> 3-oxoeicosasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40165", "l": "(R)-glycerate + 2 H(+) + NADPH => D-glyceraldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37143", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421218", "l": "xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49324", "l": "(5R,6S)-5,6-epoxi-capsanthin = all-trans-capsorubin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57076", "l": "3-oxoisoapionate 4-phosphate + H2O = (2R)-3-phosphoglycerate + glycolate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.28", "l": "\"3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33929", "l": "2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde => 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60425", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + valerianol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392195", "l": "Gi activation by P2Y purinoceptor 12 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103041", "l": "thiosulfate-thioredoxin sulfurtransferase activity", "d": ["Catalysis of the reaction: hydroxidodioxidosulfidosulfate + a reduced thioredoxin = sulfite + hydrogen sulfide + H+ + an oxidized thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24458", "l": "alpha-ribazole + phosphate => alpha-ribazole 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25703", "l": "N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008696", "l": "4-amino-4-deoxychorismate lyase activity", "d": ["Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H+ + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166082", "l": "IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833441", "l": "NS1 (1C) binds to IRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730862", "l": "Autophosphorylation of LYN kinase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3065959", "l": "An unknown protease degrades hCBXs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29723", "l": "glyoxylate(in) = glyoxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483219", "l": "PC is exchanged with PI by PITPNB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0047936", "l": "glucose 1-dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604732", "l": "Autocatalytic activation of proMMP13 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14039", "l": "cortisone + H(+) + NADPH => 4,5beta-dihydrocortisone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55351", "l": "all-trans-retinol <=> 9-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6795460", "l": "SGK1 phosphorylates MDM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69652", "l": "cumene hydroperoxide + 2 glutathione => 2-phenylpropan-2-ol + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353430", "l": "Binding of Pol eta to a DNA template containing a lesion (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214857", "l": "DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12951", "l": "2-dehydro-3-deoxy-D-fuconate + H2O => D-fuconate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24252", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41161", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + glutarate + H(+) => 1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102383", "l": "steviol 19-O glucosyltransferase activity", "d": ["Catalysis of the reaction: steviol + UDP-alpha-D-glucose = 19-O-beta-glucopyranosyl-steviol + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68587", "l": "ATP + H2O + L-tryptophan(out) <=> ADP + H(+) + L-tryptophan(in) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682377", "l": "LC3 de-lipidation by ATG4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2317332", "l": "PIP3 recruits AKT to the membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21001", "l": "1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene => 1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381466", "l": "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32512", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O => (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17806", "l": "H2O + S-adenosyl-L-homocysteine => adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53370", "l": "H(+) + NADPH + uridine(17) in tRNA => 5,6-dihydrouridine(17) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395768", "l": "LPL hydrolyses TGs from mature CMs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050682", "l": "AF-2 domain binding", "d": ["Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607746", "l": "PKC-delta is activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483089", "l": "PE is converted to PS by PTDSS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016972", "l": "thiol oxidase activity", "d": ["Catalysis of the reaction: 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + 2 H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052917", "l": "dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase", "d": ["Catalysis of the addition of mannose to dolichyl-pyrophosphate Man7GlcNAc2 (also written as Man7GlcNAc2-PP-Dol) in alpha-(1->6) linkage, producing Man8GlcNAc2-PP-Dol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25113", "l": "H2O + pyridoxine 5'-phosphate => phosphate + pyridoxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47689", "l": "cis-4-hydroxy-L-proline + NADP(+) => Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9650858", "l": "Meglitinides bind ABCC8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45395", "l": "H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11622", "l": "2-oxopent-4-enoate + chloride + H(+) + NH4(+) => H2O + L-2-amino-4-chloropent-4-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77557", "l": "a 1,3-diacyl-sn-glycerol + CoA => a 3-acyl-sn-glycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59126", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + AMP + diphosphate => (S)-2,3-diaminopropanoate + ATP + citrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990935", "l": "splicing factor binding", "d": ["Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106277", "l": "biliverdin reductase (NADPH) activity", "d": ["Catalysis of the reaction: bilirubin + NADP+ = biliverdin + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30870", "l": "H2O + indole-3-acetaldehyde + NAD(+) <=> (indol-3-yl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65962", "l": "ADP + H(+) + leukotriene C4(in) + phosphate => ATP + H2O + leukotriene C4(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.74", "l": "\"glucan 1,4-beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2089971", "l": "Secretion of collagens (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34352", "l": "(2E)-geranial + H2O + NAD(+) => geranate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72069", "l": "ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate => (2S)-2-aminobutanoate + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21471", "l": "dTDP-alpha-D-mycaminose + tylactone <=> 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12015", "l": "ATP + thiamine <=> ADP + H(+) + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28971", "l": "H(+)(in) + shikimate(in) = H(+)(out) + shikimate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694409", "l": "Nucleotide exchange on RAB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73194", "l": "(2R,3S,11R)-aszonalenin + acetyl-CoA <=> (2R,3S,11R)-acetylaszonalenin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28699", "l": "Mn(2+)(in) = Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663363", "l": "Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23547", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose <=> a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39928", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15243", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19905", "l": "NAD(+) + spermidine = dehydrospermidine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83677", "l": "C4 deamination of cytidine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44181", "l": "2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047790", "l": "creatinine deaminase activity", "d": ["Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12121", "l": "alpha-D-glucose 1-phosphate + ATP + H(+) => ADP-alpha-D-glucose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9669893", "l": "KIT binds type I TKIs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693478", "l": "HTR1A binds HTR1A agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32201", "l": "9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => androsta-1,4-diene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483197", "l": "PTPMT1 dephosphorylates PGP to PG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18101", "l": "cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.66", "l": "\"cis-dihydroethylcatechol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77277", "l": "1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2203479", "l": "STAB2 (FEEL-2) binds ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56890", "l": "UDP-4-dehydro-beta-L-rhamnose => UDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19680", "l": "9'-cis-neoxanthin + O2 <=> (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9732629", "l": "PPARG binds PPARG agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371435", "l": "Constitutive phosphorylation by GSK3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828716", "l": "G mRNA is translated into membrane-bound G protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34043", "l": "5-phospho-alpha-D-ribose 1-diphosphate + neamine = 5''-phosphoribostamycin + diphosphate", "d": [], "t": []}, {"i": "EC:2.4.2.49", "l": "\"neamine phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25546", "l": "diphosphate + ent-pimara-9(11),15-diene => ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28871", "l": "D-fructuronate(in) + H(+)(in) = D-fructuronate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11778", "l": "(9Z)-octadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38643", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.110", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17744", "l": "NAD(+) + shikimate <=> 3-dehydroshikimate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322422", "l": "Beta-catenin recruits SMARCA4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249378", "l": "STING recruits TBK1 and STAT6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41761", "l": "a ganglioside GM3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GD3 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27632", "l": "glycolaldehyde + H(+) + NADH => ethylene glycol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31528", "l": "N(omega)-hydroxy-L-arginine => guanidine + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76373", "l": "N-hydroxylation of 4-aminobiphenyl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20357", "l": "3-phenylpropanoate + H(+) + NADH + O2 = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670888", "l": "F9 variant is not secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62935", "l": "H2O + N(4)-acetylcytidine <=> acetate + cytidine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851106", "l": "p-Y705, S727 STAT3 dimer binds ICOS promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19332", "l": "nuatigenin + UDP-alpha-D-glucose <=> H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14062", "l": "H2O + N-(carboxymethyl)-D-alanine + NAD(+) => glycine + H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938853", "l": "CDK6 binds RUNX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38159", "l": "(2S,3S)-hydroxyarginine = (2S,3R)-capreomycidine + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.145", "l": "\"capreomycidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51085", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696267", "l": "RND3 binds GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41427", "l": "2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 <=> formate + grixazone A + H(+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22658", "l": "CMP + H(+) + L-serine-phosphoethanolamine => CDP-ethanolamine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796040", "l": "NFE2L2 dependent KEAP1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112395", "l": "Abortive termination of elongation after arrest (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913451", "l": "IL3RB is phosphorylated on Ser-585 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40971", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071161", "l": "cyanophycin synthetase activity (L-arginine-adding)", "d": ["Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-arginine = ADP + phosphate + [L-Asp(4-L-Arg)]n+1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55675", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318590", "l": "Defective MMACHC does not decyanate CNCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990655", "l": "4 iron, 3 sulfur cluster binding", "d": ["Binding to a 4 iron, 3 sulfur (4Fe-3S) cluster, an uncommon iron-sulfur cluster with unique properties found in oxygen-tolerant Ni-Fe hydrogenases of various bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873794", "l": "PCTP binds PC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0003995", "l": "acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74961", "l": "(3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate => (3R)-3-isocyanylbutanoate + ATP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451461", "l": "IRAK4 binds to the activated TLR7 or 21 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77021", "l": "2-hydroxycyclohexan-1-one + H(+) + NADH + NH4(+) => 2-aminocyclohexanol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35307", "l": "H(+) + NADH + O2 + salicylate = 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.172", "l": "\"salicylate 5-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10909", "l": "3'-phosphoadenylyl sulfate + glycolithocholate => adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18810", "l": "L-alanine + oxomalonate => aminomalonate + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69244", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate = 5-methylsulfinylpentyl nitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44892", "l": "an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose = an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67777", "l": "a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H2O => a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65974", "l": "a peptide antigen(out) + ADP + H(+) + phosphate => a peptide antigen(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.19", "l": "\"steroid 17alpha-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.197202967246071", "identifiers": [{"i": "GO:0015149", "l": "hexose transmembrane transporter activity", "d": ["Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12771", "l": "2-dehydro-D-gluconate + AH2 => A + D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36925", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + CO2 + CoA => (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834070", "l": "PRKN ubiquitinates MOM substrates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848392", "l": "IL18BP binds IL18 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32956", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74891", "l": "CO2(out) = CO2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62322", "l": "(+)-isomalbrancheamide B + FADH2 => (+)-premalbrancheamide + chloride + FAD + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050556", "l": "deacetylisoipecoside synthase activity", "d": ["Catalysis of the reaction: deacetylisoipecoside + H2O = dopamine + secologanin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004113", "l": "2',3'-cyclic-nucleotide 3'-phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614605", "l": "Persulfide sulfur is dioxygenated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42738", "l": "H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649671", "l": "NEIL1 recognizes and binds FapyA-dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781922", "l": "USP13 binds UFD1L:SKP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211968", "l": "CYP2W1 oxidises INDOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53207", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.50", "l": "\"noroxomaritidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201611", "l": "Caspase-mediated cleavage of Rock-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54327", "l": "a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] <=> a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69575", "l": "dIMP + inosine <=> 2'-deoxyinosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44060", "l": "2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17414", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine => an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42363", "l": "D-allulose <=> keto-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33927", "l": "4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 = 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde", "d": [], "t": []}, {"i": "EC:1.14.13.163", "l": "\"6-hydroxy-3-succinoylpyridine 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38200", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63454", "l": "GMP + H(+) + oxidized 3PG-factor420-0 => 3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28320", "l": "scutellarin + UDP => scutellarein + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167484", "l": "Fall Back to Closed Pre-initiation Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70012", "l": "2-aminobenzoyl-AMP + CoA => AMP + anthraniloyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75761", "l": "10-hydroxy-(11E)-octadecenoate => (9Z,11E)-octadecadienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77097", "l": "5-S-cysteinyldopaquinone + L-dopa => 5-S-cysteinyldopa + L-dopaquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47592", "l": "a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GP1c (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36595", "l": "hydrogen sulfide + NADP(+) = NADPH + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59634", "l": "D-xylobiono-1,5-lactone + H2O2 => D-xylobiose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44261", "l": "2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA => 4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210277", "l": "Interaction of PECAM-1 and SHP-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44353", "l": "ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate => ADP + dapdiamide C + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66309", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose => an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0046994", "l": "oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound."], "t": []}, {"i": "EC:1.12.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13925", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20299", "l": "a carboxylate + aniline + H(+) => an anilide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43773", "l": "guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428918", "l": "Dissociation of the TP:G13 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48836", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611277", "l": "P2RY12 binds P2RY12 antagonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39438", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912790", "l": "CBL binds CRK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444572", "l": "Zinc is an agonist of GPR39 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77743", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol = a 1-acyl-sn-glycero-3-phosphocholine + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47082", "l": "17beta-hydroxy-5beta-estran-3-one + NADP(+) => 17beta-hydroxyestr-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70899", "l": "histidine => urocanate + NH4+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0051377", "l": "mannose-ethanolamine phosphotransferase activity", "d": ["Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor."], "t": []}, {"i": "REACT:R-HSA-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851890", "l": "MET phosphorylates SHC1-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050247", "l": "raucaffricine beta-glucosidase activity", "d": ["Catalysis of the reaction: H2O + raucaffricine = D-glucose + vomilenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018811", "l": "cyclohex-1-ene-1-carboxyl-CoA hydratase activity", "d": ["Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49860", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47885", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16761", "l": "chlorohydroquinone + O2 = 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56349", "l": "4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 => 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10275", "l": "a 1,2-diacyl-sn-glycerol + ATP <=> a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.300", "l": "\"pavine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64266", "l": "atrochrysone + CO2 => atrochrysone carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102611", "l": "(+)-secoisolariciresinol monoglucoside glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-secoisolariciresinol monoglucoside + UDP-alpha-D-glucose = (+)-secoisolariciresinol diglucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45582", "l": "D-galactaro-1,4-lactone => D-galactaro-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20950", "l": "CO2 + sulfoacetaldehyde => 3-sulfopyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53767", "l": "allocholate + lithocholoyl-CoA <=> allocholoyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17889", "l": "H2O + phosphoethanolamine = acetaldehyde + NH4(+) + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.2", "l": "\"ethanolamine-phosphate phospho-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73260", "l": "cirsiliol + S-adenosyl-L-methionine => eupatorin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59987", "l": "an N(2)-acyl-L-glutamine + H2O <=> a carboxylate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24427", "l": "2 glutathione + L-dehydroascorbate <=> glutathione disulfide + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28685", "l": "iminosuccinate + ubiquinol-8 => L-aspartate + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28767", "l": "ethylnitronate + O2 = acetaldehyde + chemical entity + H(+) + nitrite", "d": [], "t": []}, {"i": "EC:1.13.12.16", "l": "\"nitronate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30802", "l": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) <=> acetoacetyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61461", "l": "a cytidine in RNA + S-adenosyl-L-methionine => a 5-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66275", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28308", "l": "beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21815", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191830", "l": "snRNP nuclear import and release (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570554", "l": "SUMOylation of MDC1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60128", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59826", "l": "L-glutamate + pyridoxal 5'-phosphate => 2-oxoglutarate + pyridoxamine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39613", "l": "(3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0030597", "l": "RNA glycosylase activity", "d": ["Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11197", "l": "5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide => alpha-ribazole 5'-phosphate + H(+) + nicotinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9854672", "l": "FAD attaches to SDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48223", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA <=> (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30548", "l": "(3S)-hydroxyhexanoyl-CoA => (2E)-hexenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51880", "l": "3,4,6-trichlorocatechol + O2 = (2Z,4E)-2,3,5-trichloromuconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9011543", "l": "DCA binds PDK2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450984", "l": "IDH2 dimer decarboxylates isocitrate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604834", "l": "SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171288", "l": "Cleavage of the viral Env gp160 precursor polyprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809521", "l": "BPIF binds bacteria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008120", "l": "ceramide glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029456", "l": "RAC1 and CDC42 activate PAK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220976", "l": "NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421454", "l": "Transport of protoporphyrin IX from the mitochondrial intermembrane space into the mitochondrial matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48268", "l": "4',4'-dihydroxyechinenone = canthaxanthin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036199", "l": "cholest-4-en-3-one 26-monooxygenase activity", "d": ["Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617874", "l": "HOXD4 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984821", "l": "Kinesin-12 is a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27286", "l": "(S)-acetoin + NAD(+) = diacetyl + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.304", "l": "\"diacetyl reductase [(S)-acetoin forming]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21620", "l": "FMNH2 + NAD(+) = FMN + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5627072", "l": "RHOQ binds GOPC:CFTR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0032129", "l": "histone H3K9 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13187", "l": "hydroxymethylbilane + 4 NH4(+) => H2O + 4 porphobilinogen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34041", "l": "6'-oxoparomamine + L-glutamate => 2-oxoglutarate + neamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17541", "l": "an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.7", "l": "\"aryl-alcohol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54205", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 => 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70056", "l": "AH2 + cremeomycin => 2-hydroxy-4-methoxybenzoate + A + N2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981657", "l": "IL34 dimer binds PTPRZ1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426223", "l": "Cation influx mediated by TRPC3/6/7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76671", "l": "furfural + H2O + NADP(+) = 2-furoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2750181", "l": "Syndecan-2 binds CASK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38806", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110322", "l": "Formation of Pol zeta complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68388", "l": "2 5,6-dihydroxyindole-2-carboxylate + O2 = 2 H2O + 2 indole-5,6-quinone-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23609", "l": "H(+) + H2O + N-isopropylammelide => cyanurate + isopropylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74691", "l": "2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine = 4 5'-deoxyadenosine + 2 A + a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 H(+) + 4 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22542", "l": "9-riburonosyladenine + H(+) + H2O2 => 5'-dehydroadenosine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13742", "l": "3-phenylpyruvate + L-tryptophan => indole-3-pyruvate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51163", "l": "cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448744", "l": "IL20RA binds IL20RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.37", "l": "\"leukocyte elastase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16891", "l": "6-acetamido-3-oxohexanoate + L-glutamate => 2-oxoglutarate + 6-acetamido-3-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38011", "l": "chlorophyll a + H2O = chlorophyllide a + H(+) + phytol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41302", "l": "H2O + N-(9Z-octadecenoyl)-sphing-4-enine <=> (9Z)-octadecenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3204303", "l": "MRE11 binds cytosolic DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66446", "l": "(E)-4-hexen-3-one + H(+) + NADPH => hexan-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20232", "l": "2,3-dihydroxybenzoate + ATP + H(+) <=> 2,3-dihydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427570", "l": "Group 3 - Selective Cl- transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810076", "l": "DDO oxidizes D-Asp to OA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54407", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54932", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] = (2E,9Z)-hexadecadienoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36927", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29588", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) => 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40938", "l": "a 1-acylglycerone 3-phosphate + hexadecan-1-ol <=> 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61896", "l": "betaenone C = betaenone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602901", "l": "Defective GSS does not synthesize GSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76087", "l": "a dicarboxylate(in) + kynurenate(out) = a dicarboxylate(out) + kynurenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395340", "l": "Formation of hydroxyallysine by LOX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62584", "l": "ATP + H2O + L-tyrosine(out) = ADP + H(+) + L-tyrosine(in) + phosphate", "d": [], "t": []}, {"i": "EC:7.4.2.13", "l": "\"ABC-type tyrosine transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76102", "l": "a dicarboxylate(in) + xanthurenate(out) <=> a dicarboxylate(out) + xanthurenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77997", "l": "9-(acyloxy)-octadecanoate + a 2-acylglycerol => 9-hydroxy-octadecanoate + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46444", "l": "(11Z)-hexadecenoyl-CoA + AH2 + O2 = (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.15", "l": "\"(11Z)-hexadec-11-enoyl-CoA conjugase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876484", "l": "NPC2 transfers CHOL to NPC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50003", "l": "butane + H(+) + NADH + O2 <=> butan-1-ol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796626", "l": "MIB2 ubiquitinates CFLAR  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66951", "l": "acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417829", "l": "P2RY12 binds ADP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11977", "l": "anhydrotetracycline + H(+) + NADPH + O2 => 5a,11a-dehydrotetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74720", "l": "myricetin + S-adenosyl-L-methionine => 7-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50559", "l": "prostaglandin D2 <=> H2O + prostaglandin J2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110219", "l": "Cleavage of thymine by TDG glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13587", "l": "ADP + butanoyl phosphate => ATP + butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34099", "l": "carboxynorspermidine + H(+) = CO2 + norspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167134", "l": "Newly formed phosphodiester bond stabilized and PPi released (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856189", "l": "TNFSF8 binds TNFRSF8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66467", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O <=> scalarane-17alpha-19-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40584", "l": "H2O + hexanedioyl-CoA => CoA + H(+) + hexanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67283", "l": "(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione <=> (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5333671", "l": "CLCAs self cleave (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68873", "l": "(E)-cinnamate + ATP + H(+) + NADPH => (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45959", "l": "(9Z)-octadecenoyl-CoA(in) <=> (9Z)-octadecenoyl-CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58140", "l": "acetyl-AMP + cytidine(34) in elongator tRNA(Met) = AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30466", "l": "(2Z,6Z)-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45802", "l": "10-decarboxymethylaclacinomycin T + A + CO2 + H2O => 15-demethylaclacinomycin T + AH2 + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690873", "l": "ACO1 binds 4Fe-4S (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39511", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA = (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51994", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27378", "l": "(R)-glycerate + ATP => (2R)-2-phosphoglycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21573", "l": "3-hydroxy-2-methyl-1H-quinolin-4-one + O2 => CO + H(+) + N-acetylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56786", "l": "(6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60353", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + O2 => CO + H(+) + N-octanoylanthranilate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28997", "l": "H(+)(in) + L-threonine(out) => H(+)(out) + L-threonine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.56", "l": "\"7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9604308", "l": "NICD4 traffics to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51478", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O => a ribonucleoside 5'-triphosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009072", "l": "STAT3 phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196753", "l": "2xPPCS ligates PPanK with Cys (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694792", "l": "nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141186", "l": "MAOA:FAD oxidatively deaminates of 5HT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707505", "l": "Hemes bind to CLEC1B dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9854415", "l": "ACAT1 tetramer acetylates IDH2 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264615", "l": "Loading of acetylcholine in synaptic vesicles (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691150", "l": "TFR2 dimer binds 2xholoTF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61502", "l": "delphinidin 3-O-beta-D-glucoside + UDP => delphinidin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9612219", "l": "ERBB4s80 binds to SRC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25506", "l": "beta-phellandrene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625188", "l": "HSPA8 transports unfolded substrate to lysosomal lumen for degradation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799466", "l": "TP53I3 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41421", "l": "2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2 => CO2 + grixazone B + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65926", "l": "2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine => 2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35059", "l": "chloramphenicol(in) + H(+)(out) = chloramphenicol(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23731", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 <=> A + H2O + prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11705", "l": "2 H(+) + N-(carboxyaminomethyl)urea => CO2 + N-(aminomethyl)urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29003", "l": "H(+)(out) + L-homoserine(in) = H(+)(in) + L-homoserine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40693", "l": "1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0032440", "l": "2-alkenal reductase [NAD(P)+] activity", "d": ["Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782820", "l": "USP17 deubiquitinates SUDS3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24016", "l": "16-epivellosimine + acetyl-CoA = CoA + vinorine", "d": [], "t": []}, {"i": "EC:2.3.1.160", "l": "\"vinorine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35183", "l": "5-hydroxythiophene-2-carbonyl-CoA + H2O = 4-carboxy-2-thioxobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426032", "l": "DAG is metabolized by DAGL to 2-AG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12591", "l": "a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a ganglioside GM2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31704", "l": "2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37538", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39979", "l": "(+-)-pavine + S-adenosyl-L-methionine = H(+) + N-methylpavine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653180", "l": "GABA translocates from cytosol to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53689", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72974", "l": "5-oxo-L-proline(out) + 2 Na(+)(out) <=> 5-oxo-L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170026", "l": "UCP1 imports a proton (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52153", "l": "(Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose => (Z)-indolylmethyl desulfoglucosinolate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218804", "l": "p38 MAPK activation by VEGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43339", "l": "H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in) <=> CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72486", "l": "(S)-malate(in) + citrate(out) <=> (S)-malate(out) + citrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247922", "l": "GGCT transforms gGluCys to OPRO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045506", "l": "interleukin-24 receptor activity", "d": ["Combining with interleukin-24 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18511", "l": "2 H2O + NAD(+) => H(+) + H2O2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11984", "l": "AH2 + O2 + progesterone = A + H2O + testosterone acetate", "d": [], "t": []}, {"i": "EC:1.14.99.4", "l": "\"progesterone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684169", "l": "G6B binds PTPN6,PTPN11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30615", "l": "15-cis-phytoene + 2 A = 2 AH2 + all-trans-zeta-carotene", "d": [], "t": []}, {"i": "EC:1.3.99.29", "l": "\"phytoene desaturase (zeta-carotene-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2730835", "l": "Autophosphorylation of PKC-theta (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71771", "l": "2 Cu(+) + H(+) + NADP(+) = 2 Cu(2+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44624", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.384", "l": "\"dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.16", "l": "\"citrate synthase (unknown stereospecificity)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60092", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) = 3-dehydro-4alpha-methylzymosterol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17805", "l": "H2O + S-adenosyl-L-homocysteine = adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14759", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate => 2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.99.-", "l": "\"Acting on other compounds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850794", "l": "SPINK6 binds KLK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75977", "l": "(S)-cis-N-methylstylopine + S-adenosyl-L-homocysteine => (S)-stylopine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46216", "l": "H(+) + NADPH + progesterone = 3beta-hydroxypregn-4-ene-20-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38409", "l": "(9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30759", "l": "5-methylcytosine + H(+) + H2O = NH4(+) + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047937", "l": "glucose-1-phosphate phosphodismutase activity", "d": ["Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034818", "l": "ADD 9alpha-hydroxylase activity", "d": ["Catalysis of the reaction: androsta-1,4-diene-3,17-dione + reduced ferredoxin + O2 = 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + oxidized ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42381", "l": "2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O => 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350604", "l": "Agmatine + H2O <=> putrescine + urea (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29270", "l": "L-valine(in) + Na(+)(in) <=> L-valine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693125", "l": "RHOF binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.3.6", "l": "\"farnesylcysteine lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78982", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> bonnadiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448958", "l": "Nuclear translocation of p38 MAPK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68302", "l": "CoA + O-tetradecanoyl-L-seryl-[protein] => L-seryl-[protein] + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67755", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58406", "l": "H(+) + hexanal + NADPH => hexan-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606564", "l": "GALC hydrolyzes GalCer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297275", "l": "CD9:Izumo Binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22427", "l": "an S-alkyl-L-cysteine + H2O <=> an alkyl thiol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55700", "l": "an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O = an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.25", "l": "\"carvone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870461", "l": "RABGGTA and RABGGTB bind (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606564", "l": "GALC hydrolyzes GalCer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14750", "l": "1-hydroxy-2-naphthoate + O2 => (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0019975", "l": "interleukin-17 binding", "d": ["Binding to a member of the interleukin-17 family of cytokines."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.29", "l": "\"aspartate/glutamate leucyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16819", "l": "6-phospho-2-dehydro-D-gluconate + H(+) + NADPH => 6-phospho-D-gluconate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006325", "l": "EPO binds EPOR:JAK2:LYN:IRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-744886", "l": "The Ligand:GPCR:Gs complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.69", "l": "\"monoterpenol O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66716", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate = (2S)-3-sulfolactaldehyde + D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34629", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730847", "l": "Hydrolysis of PIP2 by PLCG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65396", "l": "8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47553", "l": "glycodeoxycholate + H2O => deoxycholate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57102", "l": "S-methyl-1-thio-D-xylulose 5-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31455", "l": "NAD(+) + reduced riboflavin = 2 H(+) + NADH + riboflavin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051449", "l": "thyrotropin-releasing hormone binding", "d": ["Binding to thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18820", "l": "acetyl-CoA + malonate <=> acetate + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3076905", "l": "Extracellular BTD hydrolyses BCTN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13678", "l": "D-ribulose 5-phosphate => D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37005", "l": "3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA => (11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418662", "l": "Src activation following P2Y purinoceptor activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17161", "l": "2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43890", "l": "[sulfur carrier]-SH + [sulfur-carrier protein]-L-cysteine => [sulfur carrier]-H + [sulfur-carrier protein]-S-sulfanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42065", "l": "ATP + GTP => 2',3'-cGAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28401", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate <=> L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030911", "l": "TPR domain binding", "d": ["Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54631", "l": "2-oxoglutarate + dodecanoyl-CoA + O2 <=> 2-hydroxydodecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610730", "l": "GSK3 phosphorylates p-GLI2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74633", "l": "(6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate + acetate + H(+) => 3-methyl-2-oxobutanoate + O-acetyl-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625540", "l": "Cys-sulfenyl chloride is converted to Cys-sulfenic acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44467", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> a 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72090", "l": "2 Na(+)(out) + taurodeoxycholate(out) <=> 2 Na(+)(in) + taurodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66769", "l": "ATP + coproporphyrin I(in) + H2O => ADP + coproporphyrin I(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22666", "l": "1,2-di-O-sinapoyl beta-D-glucose + D-glucose => 2 1-O-(trans-sinapoyl)-beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74947", "l": "p-MII:SAG dissociates to p-RHO and SAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976801", "l": "Complement factor I complex formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140728", "l": "GC-box binding", "d": ["Binding to a GC-box, a DNA motif with the consensus sequence GGGCGG that is located upstream of the start point of eukaryotic transcription units. The GC-box may occur in multiple copies or in either orientation relative to the transcription start site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18639", "l": "H(+) + NADPH => H2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391871", "l": "Autophosphorylation of NCAM1 bound Fyn (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48623", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione <=> (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9649108", "l": "HTR3A pentamer binds 5HT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68581", "l": "ATP + H2O + L-kynurenine(out) => ADP + H(+) + L-kynurenine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63998", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61449", "l": "H(+) + NADPH + O2 + tigecycline => 11a-hydroxytigecycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052767", "l": "mannosyl-oligosaccharide 1,6-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of the alpha-(1->6) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23005", "l": "a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.51", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54765", "l": "5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine => [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27738", "l": "2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691363", "l": "nsp12 binds nsp7 and nsp8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77727", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol = 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77164", "l": "H(+) + hercynine + N-acetyl-1-seleno-beta-D-glucosamine + O2 => H2O + hercynyl-SeGlcNAc selenoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55265", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine => di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43412", "l": "a D-galactosylceramide + H2O = an N-acyl-sphingoid base + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74258", "l": "XDH oxidizes xanthine to form urate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839388", "l": "TGFBR3 translocation to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9005995", "l": "MECP2 binds the SIN3A co-repressor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.91", "l": "\"sphingosine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30699", "l": "2-oxoglutarate + beta-alanine = 3-oxopropanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.120", "l": "\"beta-alanine--2-oxoglutarate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62073", "l": "D-galactose 6-phosphate + NADP(+) => 6-phospho-D-galactono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376200", "l": "SLC7A10-mediated uptake of small neutral amino acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38851", "l": "H(+) + tetracenomycin F2 = H2O + tetracenomycin F1", "d": [], "t": []}, {"i": "EC:4.2.1.154", "l": "\"tetracenomycin F2 cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19237", "l": "4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide", "d": [], "t": []}, {"i": "EC:5.4.99.14", "l": "\"4-carboxymethyl-4-methylbutenolide mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865994", "l": "GAB1 binds PTPN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432946", "l": "PARVB/Affixin interacts with alpha PIX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.57", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033872", "l": "[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130706", "l": "MHC class II antigen processing (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3785768", "l": "MRN complex binds DNA double strand breaks (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419389", "l": "LPA-binding receptors bind LPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731051", "l": "SARS-CoV-1 3b binds to RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21468", "l": "dTDP-alpha-D-mycaminose + tylactone = 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.316", "l": "\"tylactone mycaminosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5333051", "l": "RPA1 binds HSF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36195", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46568", "l": "5-hexenoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-hexynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69353", "l": "2 (E)-prop-1-en-1-SO-peroxol => H2O + thiosulfinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928619", "l": "PAK1 binds RAC1:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21030", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein] => acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445448", "l": "HHIP binds Hedgehog (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013159", "l": "CDC42 GEFs activate CDC42 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102867", "l": "molybdenum cofactor sulfurtransferase activity", "d": ["Catalysis of the reaction: 2 H+ + MoO2-molybdopterin cofactor(2-) + L-cysteine = thio-molybdenum cofactor + L-alanine + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50405", "l": "(2-aminobenzoyl)acetate + H(+) + S-octanoyl-L-cysteinyl-[PqsC protein] => 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77604", "l": "2 3-octadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) => 3-octadecanoyl-sn-glycero-1-phospho-(3'-octadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229283", "l": "LCNs bind lipids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66853", "l": "(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.39", "l": "\"enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422454", "l": "Polysialylation of NCAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10397", "l": "an L-alpha-amino acid + H2O + NAD(+) => a 2-oxocarboxylate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20324", "l": "L-proline + NAD(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9823816", "l": "OPTN binds CASP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57230", "l": "N(2)-(1-hydroxy-2-oxoethyl)-GDP => GDP + glyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.71009653994831", "identifiers": [{"i": "GO:0000981", "l": "DNA-binding transcription factor activity, RNA polymerase II-specific", "d": ["A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218821", "l": "PDK1 phosphorylates PKC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60979", "l": "(E)-4-hydroxynon-2-en-1-ol + NAD(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75724", "l": "(9Z,12Z)-octadecadienoate + H2O => (10S)-hydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11196", "l": "5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate", "d": [], "t": []}, {"i": "EC:2.4.2.21", "l": "\"nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0001099", "l": "basal RNA polymerase II transcription machinery binding", "d": ["Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140806", "l": "SERPINC1 binds SERPINC1 activators (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61299", "l": "5-deoxy-alpha-D-ribose 1-phosphate <=> 5-deoxy-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428917", "l": "G13 activation by TP receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043754", "l": "dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity", "d": ["Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955869", "l": "Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796626", "l": "MIB2 ubiquitinates CFLAR  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034565", "l": "1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity", "d": ["Catalysis of the reaction: 1-nitro-1,2-dihydro-1,3,5-triazine + 2 H2O = 1-nitro-1,3,5-triazinane-2,4-diol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917841", "l": "Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.37", "l": "\"1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66567", "l": "histamine + L-glutaminyl-[protein] <=> 5-histaminyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14259", "l": "a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50793", "l": "18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => aldosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33028", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spheroidene => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + spheroiden-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372559", "l": "aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44999", "l": "(R)-carnitine + acetoacetyl-CoA <=> CoA + O-3-oxobutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263490", "l": "Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605057", "l": "ABCA1 gene transcription regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627106", "l": "SMAC (DIABLO) forms dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110215", "l": "Cleavage of uracil by UNG glycosylase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38144", "l": "carbon disulfide + 2 H2O => CO2 + 2 H(+) + 2 hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114544", "l": "p115-RhoGEF activation of RHOA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371353", "l": "Soluble TNF-α binds TNFR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24962", "l": "[excited state blue fluorescent protein] + CO2 => apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683760", "l": "GalNAc is transferred onto 3a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55594", "l": "(3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP] => 2 (3R)-hydroxydecanoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25483", "l": "acetoacetate + succinyl-CoA <=> acetoacetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.8", "l": "\"ATP diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202947", "l": "Caspase mediated cleavage of APC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64417", "l": "D-xylofuranose + NADP(+) => D-xylono-1,4-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67474", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine => H2O + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102894", "l": "UDPG:cyclo-DOPA 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + leucodopachrome = H+ + cyclo-dopa 5-O-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37736", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102659", "l": "UDP-glucose: 4-methylthiobutylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 4-methylthiobutylhydroximate = H+ + 3-methylthiopropyl-desulfoglucosinolate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848864", "l": "PTK6 binds ARAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49176", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77860", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-phenylalanine + O2 => (2S)-3-phenyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76302", "l": "L-aspartate(in) + L-cystine(out) <=> L-aspartate(out) + L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39550", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA <=> (2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38316", "l": "chorismate => 3-hydroxybenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090581", "l": "protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannosylglycerate(out) = protein cysteine + mannosylglycerate phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376122", "l": "DSCAM/DSCAML1 homodimerization (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13761", "l": "L-methionine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine", "d": [], "t": []}, {"i": "EC:2.1.1.12", "l": "\"methionine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928639", "l": "p-EFNB binds GRB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24148", "l": "D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.2.7.6", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30665", "l": "hapalindole H => 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10330", "l": "a 2-hydroxycarbonyl + H(+) + NADH => an L-glycol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62227", "l": "H(+) + NADPH + neopatulin <=> (E)-ascladiol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114284", "l": "Release of Cytochrome c from mitochondria (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42171", "l": "20alpha-hydroxy-5beta-pregnan-3-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63147", "l": "H2O + N-(15Z-tetracosenoyl)-ethanolamine <=> (15Z)-tetracosenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9646468", "l": "mTORC1 binds RHEB:GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632679", "l": "EVC2:EVC binds p-SMO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49910", "l": "(R)-carnitine(in) + O-acetyl-(R)-carnitine(out) => (R)-carnitine(out) + O-acetyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944240", "l": "Association of procollagen type III (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59111", "l": "chenodeoxycholate + octyl beta-D-glucose <=> beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73315", "l": "1D-chiro-inositol(out) + 2 Na(+)(out) = 1D-chiro-inositol(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29196", "l": "(S)-dihydroorotate + a menaquinone => a menaquinol + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687107", "l": "MAPK4,6 translocate to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014454", "l": "RHOG translocates to the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0035005", "l": "1-phosphatidylinositol-4-phosphate 3-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74233", "l": "L-threonine + tRNA(Val) => H2O + L-threonyl-tRNA(Val)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015124", "l": "allantoate transmembrane transporter activity", "d": ["Enables the transfer of allantoate from one side of a membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9650858", "l": "Meglitinides bind ABCC8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24722", "l": "H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 = H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825306", "l": "Expression of DLL3 in presomitic mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803892", "l": "SFN dimer binds BAX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9909159", "l": "HK1 phosphorylates Mannose to Man6P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928591", "l": "EPH:EFN tetramers oligomerise (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36256", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61754", "l": "H(+) + rebaudioside B + UDP => steviolbioside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65305", "l": "2-oxoglutarate + O2 + verruculide A => chrodrimanin T + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46465", "l": "(24S)-25-epoxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S,25)-epoxy-7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917730", "l": "Cargo Recognition And Sorting (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.193", "l": "\"ginsenosidase type I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40385", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62070", "l": "2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH => 2-deoxy-D-glucose 6-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44441", "l": "a 1,3-diacylglycerol + a 1-acylglycerol => a triacylglycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44792", "l": "2-demethylmenaquinol-12 + S-adenosyl-L-methionine = H(+) + menaquinol-12 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8867344", "l": "OMA1 hydrolyses OPA1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833031", "l": "Polyadenylation of respiratory syncytial virus subgenomic positive-sense mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29612", "l": "H2O + NADP(+) + nitrous oxide => H(+) + NADPH + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-445079", "l": "Phosphorylation of L1 by ERK (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433066", "l": "Unknown NAT transfers COCH3 to AFXBO-C, AFNBO-C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174446", "l": "Removal of remaining Flap from the C-strand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396370", "l": "VTN binds collagens II, III and V (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047178", "l": "glycerophospholipid acyltransferase (CoA-dependent) activity", "d": ["Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421836", "l": "trans-Golgi Network Derived Vesicle Uncoating (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24326", "l": "1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+) => 6-oxocineole + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15174", "l": "H(+) + H2O2 + NADPH => 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73819", "l": "choline(in) + 2 H(+)(out) = choline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030059", "l": "aralkylamine dehydrogenase (azurin) activity", "d": ["Catalysis of the reaction: an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H+ + NH4+ + 2 reduced [azurin]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862771", "l": "PLA2G2A binds bacterial phospholipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811508", "l": "ING2-bound EP300 acetylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684033", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70994", "l": "SDH complex dehydrogenates succinate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30749", "l": "(2E)-hexadecenoyl-CoA + FADH2 => FAD + H(+) + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38170", "l": "hexadecan-1-ol + hexadecanoyl-CoA <=> CoA + hexadecanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43229", "l": "L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167429", "l": "The receptor:G-protein complex  binds GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46817", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47015", "l": "[DsrC protein]-disulfide + H(+) + hydrogen sulfide <=> [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018746", "l": "RHOQ binds effectors at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46015", "l": "(S)-malate + a quinone <=> a quinol + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2029473", "l": "Branching and elongation of mother and daughter filaments (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48201", "l": "H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA => reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866269", "l": "ARRB bind GPCRs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27620", "l": "di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate => (2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23899", "l": "5-dehydro-4-deoxy-D-glucuronate <=> 3-deoxy-D-glycero-2,5-hexodiulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018598", "l": "hydroxymethylsilanetriol oxidase activity", "d": ["Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21483", "l": "2-furoyl-CoA + A + H2O <=> 5-hydroxy-2-furoyl-CoA + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22041", "l": "H2O + N-formyl-L-aspartate => formate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50908", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.60", "l": "\"3-demethoxyubiquinol 3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237160", "l": "MTA is cleaved and phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42858", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate => 1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76293", "l": "Na(+)(in) + xanthine(in) => Na(+)(out) + xanthine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211247", "l": "Cleavage of DNA by DFF40 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048156", "l": "tau protein binding", "d": ["Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38817", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50611", "l": "leukotriene B4 + NADP(+) <=> 12-oxo-leukotriene B4 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32964", "l": "2-oxoglutaramate + H2O => 2-oxoglutarate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51120", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2 = (8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35320", "l": "H(+) + malonyl-CoA + octadecanoyl-CoA => 3-oxoeicosanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75920", "l": "H2O + NADP(+) + serinol => dihydroxyacetone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23347", "l": "a purine D-ribonucleoside + H2O <=> a purine nucleobase + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102295", "l": "4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity", "d": ["Catalysis of the reaction: 4-methylumbelliferyl glucoside + malonyl-CoA = 4-methylumbelliferone 6'-O-malonylglucoside + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31718", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190829", "l": "Lysosomal degradation of gap junction plaques (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016521", "l": "pituitary adenylate cyclase activating polypeptide activity", "d": ["The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17549", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.16", "l": "\"methylene-fatty-acyl-phospholipid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.21", "l": "\"aldose reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404144", "l": "Parenchymal atROL translocates to HSCs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851298", "l": "GPR143 binds L-Dopa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202702", "l": "CD177 binds PECAM-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12087", "l": "D-mannitol + NAD(+) <=> D-fructose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54239", "l": "1,2-didecanoyl-sn-glycerol + CDP-choline <=> 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56635", "l": "H2O + neryl diphosphate <=> 1,8-cineole + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63927", "l": "ATP + N(4)-acetylcytidine <=> ADP + H(+) + N(4)-acetylcytidine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.158", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134953", "l": "DHX36 or DHX9 binds MyD88 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007999", "l": "RUNX2 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48037", "l": "a globoside Gb4Cer (d18:1(4E)) + H2O => a globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374686", "l": "L1 interaction with Integrins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54070", "l": "diphosphate + sesterfisherol => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61833", "l": "sitosterol + UDP-alpha-D-glucose => H(+) + sitosteryl 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839378", "l": "TGFBR3 binding to ARRB1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28409", "l": "H2O + XTP <=> H(+) + phosphate + XDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46563", "l": "episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78181", "l": "a triacylglycerol + CoA => a 1,3-diacylglycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.126", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170964", "l": "FRS2 binds to active TrkA receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21813", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33805", "l": "2 H(+) + L-histidine + NADH => H2O + L-histidinal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24144", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.57", "l": "\"isohexenylglutaconyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33791", "l": "H2O + sucrose 6(F)-phosphate = beta-D-fructose + beta-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18124", "l": "an S-substituted L-cysteine + H2O <=> a thiol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863472", "l": "DAB2 binds LRP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68415", "l": "H2O + L-glutamate 5-semialdehyde + NADP(+) <=> 2 H(+) + L-glutamate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36869", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31854", "l": "(S)-2,3-epoxysqualene <=> parkeol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011748", "l": "IL9R binds JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16646", "l": "H2O + hexadecanoyl-CoA => CoA + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49393", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212222", "l": "PRC2 recruits DNA methyltransferases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29958", "l": "H(+)(in) + thymidine(in) <=> H(+)(out) + thymidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46754", "l": "7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76276", "l": "Na(+)(out) + uracil(out) => Na(+)(in) + uracil(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51555", "l": "D-sorbitol + NADP(+) <=> H(+) + L-xylo-3-hexulose + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16505", "l": "chorismate = 4-hydroxybenzoate + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.40", "l": "\"chorismate lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.-", "l": "\"Cysteine endopeptidases\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685602", "l": "NCR3LG1 binds NCR3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014294", "l": "RAC2 binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59955", "l": "2,6-dimethylheptanoyl-CoA + H2O <=> 2,6-dimethylheptanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098607", "l": "methylselenocysteine deselenhydrase activity", "d": ["Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O => pyruvic acid + NH3 + Methaneselenol."], "t": []}, {"i": "REACT:R-HSA-2408539", "l": "MeSec is hydrolysed to MeSeH by PXLP-K212-CTH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76984", "l": "1-(9Z-octadecenoyl)-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O => (9Z)-octadecenoate + 2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-1D-myo-inositol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76621", "l": "capsiate + CoA => (6E)-8-methylnon-6-enoyl-CoA + 4-hydroxy-3-methoxy-benzenemethanol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847537", "l": "RAB43:GTP binds USP8NL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22473", "l": "(R)-pantetheine + ATP => (R)-4'-phosphopantetheine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38466", "l": "a 1-acyl-sn-glycerol + an acyl-CoA <=> a 1,2-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0016730", "l": "oxidoreductase activity, acting on iron-sulfur proteins as donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.18.-.-", "l": "\"Acting on iron-sulfur proteins as donors\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694441", "l": "CSNK1D phosphorylates SEC23 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389523", "l": "BTLA interacts with HVEM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75849", "l": "SLC25A1 exchanges CIT and MAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420206", "l": "Phosphorylation of SRC-1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616116", "l": "EGR2 and SOX10 bind the MAG gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429449", "l": "Syk activation leads to SLP-76 activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72356", "l": "dehydroepiandrosterone 3-sulfate(out) + glutarate(in) => dehydroepiandrosterone 3-sulfate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54729", "l": "acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] => malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21493", "l": "2,3-dihydroxybenzoate + H(+) => catechol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086223", "l": "Collagen type IX binds integrin alpha11beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44378", "l": "a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out) => a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71199", "l": "L-ornithine(in) = L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035302", "l": "ecdysteroid 25-hydroxylase activity", "d": ["Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41123", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299318", "l": "Activation of TASK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77670", "l": "a globoside GalGb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine <=> a globoside GlcNAc-GalGb4Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52115", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA <=> 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48055", "l": "n 3'-phosphoadenylyl sulfate + dermatan <=> n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14764", "l": "H(+) + hexadecanoyl-CoA + L-serine <=> 3-oxosphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21867", "l": "an S-(2-hydroxyacyl)glutathione + H2O <=> a 2-hydroxy carboxylate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13430", "l": "2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) => 4-CDP-2-C-methyl-D-erythritol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19306", "l": "3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA => 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16278", "l": "H2O + indole-3-acetaldehyde + O2 => (indol-3-yl)acetate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0052882", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a copper protein."], "t": []}, {"i": "EC:1.20.9.-", "l": "\"With a copper protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15958", "l": "D-altronate => 2-dehydro-3-deoxy-D-gluconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39924", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69138", "l": "2 H2O2 + 2 NH4(+) + spermine dialdehyde => 2 H2O + 2 O2 + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36528", "l": "(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA => (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17504", "l": "H2O + polyneuridine aldehyde <=> 16-epivellosimine + CO2 + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30879", "l": "H2O + NAD(+) + prop-2-ynal = 2 H(+) + NADH + propynoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9007882", "l": "IL1F10 is cleaved (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28988", "l": "H(+)(in) + N-acetylneuraminate(in) => H(+)(out) + N-acetylneuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48196", "l": "H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35135", "l": "L-alanyl-L-glutamate(out) = L-alanyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937807", "l": "SRC phosphorylates RUNX3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551648", "l": "SUMOylation of TDG with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60565", "l": "2-deoxy-D-glucose + ATP => 2-deoxy-D-glucose 6-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35154", "l": "4-hydroxy-3-nitrophenylacetaldehyde + H2O + NAD(+) <=> (3-nitro-4-oxidophenyl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602170", "l": "CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52339", "l": "a long-chain fatty acid + ATP + H(+) <=> a long-chain fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41286", "l": "H2O + N-tetracosanoyl-sphing-4-enine <=> sphing-4-enine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5221061", "l": "TDG excises 5-carboxylcytosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59099", "l": "monoglucosyl-enterobactin + UDP-alpha-D-glucose <=> diglucosyl-enterobactin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709454", "l": "EPOR binds EPOR agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102936", "l": "gypsogenate-UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenate = gypsogenate-28-beta-D-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875183", "l": "CBL monoubiquitinates activated MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73798", "l": "dimethylallyl diphosphate + neoechinulin A <=> diphosphate + isoechinulin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18636", "l": "2 ATP + H2O + hydrogencarbonate + L-glutamine <=> 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0004347", "l": "glucose-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27784", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-octaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31071", "l": "(S)-2-methyl-3-oxopropanoate + L-alanine = (S)-3-amino-2-methylpropanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.11", "l": "\"carnosine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33916", "l": "4-(methylamino)butanoate + H2O + O2 => H2O2 + methylamine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983152", "l": "Transfer of ubiquitin from E1 to E2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404142", "l": "atROL binds RBP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22340", "l": "3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.97", "l": "\"3-hydroxybenzyl-alcohol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78771", "l": "3''-dehydroisoorientin = 1,5-anhydro-D-erythro-hex-1-en-3-ulose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685939", "l": "3a localizes to the cell membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10534", "l": "D-glyceraldehyde 3-phosphate + H2O + L-tryptophan => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016432", "l": "tRNA-uridine aminocarboxypropyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53813", "l": "cholestanol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-26-hydroxycholestanol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008995", "l": "ribonuclease E activity", "d": ["Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27403", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate => 2-hydroxychromene-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106235", "l": "ceramide-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: ceramide-1-phosphate + H2O = ceramide+ phosphate."], "t": []}, {"i": "RHEA:50888", "l": "an N-acylsphingoid base 1-phosphate + H2O = an N-acyl-sphingoid base + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013284", "l": "NOTCH3-ligand complex is cleaved to produce NEXT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74667", "l": "(6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate = (2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400459", "l": "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53525", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50437", "l": "prostaglandin H1 => prostaglandin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211224", "l": "Association of DFF40 with DFF45 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428262", "l": "ACER3 hydrolyzes phytoceramide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22740", "l": "a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102849", "l": "1-18:2-2-18:3-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:3-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47374", "l": "a quinol + D-glucono-1,5-lactone => a quinone + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634445", "l": "MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73063", "l": "H(+)(out) + Mn(2+)(in) = H(+)(in) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18558", "l": "1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA => 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22373", "l": "H2O + O2 + propionate 3-nitronate => 3-oxopropanoate + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848829", "l": "CBL autoubiquitinates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177920", "l": "Binding of GRB2 to GAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850777", "l": "SPINK6 binds KLK14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45865", "l": "16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16830", "l": "an aldehyde + H2O + O2 => a carboxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74092", "l": "ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65219", "l": "3-oxododecanoyl-CoA + H2O <=> 3-oxododecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77815", "l": "(2S)-3-methyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]butanoate + H(+) + H2O = 2-dehydro-D-glucose + L-valine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23411", "l": "NADP(+) + precorrin-6B <=> 2 H(+) + NADPH + precorrin-6A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71050", "l": "Trimerization of the FASL:FAS receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051749", "l": "indole acetic acid carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14324", "l": "morphine + NADP(+) <=> H(+) + morphinone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78033", "l": "a 1,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33776", "l": "a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791016", "l": "SFTPB binds itself (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624798", "l": "LBR binds KPNB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086410", "l": "CDK1 phosphorylates BORA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49463", "l": "(2Z,4E)-2-aminomuconate + H2O <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44965", "l": "(2E)-dodecenoyl-CoA + H(+) + NADPH => dodecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18719", "l": "3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine => 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374701", "l": "Phosphorylation of DCC by Fyn (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043726", "l": "5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity", "d": ["Catalysis of the reaction: 5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O = 5-amino-6-(D-ribitylamino)uracil + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030625", "l": "U11 snRNA binding", "d": ["Binding to a U11 small nuclear RNA (U11 snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67646", "l": "ADP + dZTP => ATP + dZDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73118", "l": "quercetin + S-adenosyl-L-methionine <=> H(+) + rhamnetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042014", "l": "interleukin-19 receptor activity", "d": ["Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0141052", "l": "histone H3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76526", "l": "2-dehydro-3-deoxy-L-fuconate <=> (S)-lactaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-265456", "l": "NPC1L1 binds ezetimibe (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016847", "l": "1-aminocyclopropane-1-carboxylate synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36718", "l": "sphinganine + tetracosenoyl-CoA <=> an N-tetracosenoylsphinganine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74421", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in) => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67515", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65733", "l": "2-oxoglutarate + heptyl sulfate + O2 => CO2 + H(+) + heptanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32458", "l": "(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19019", "l": "ADP + H(+) + NADH + phosphate => (6S)-NADHX + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43248", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396002", "l": "TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620103", "l": "ALDH2 transforms GTN to NO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102240", "l": "soyasapogenol B glucuronide galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-galactose + soyasapogenol B 3-O-beta-glucuronate = H+ + UDP + soyasaponin III."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237119", "l": "Acireductone is oxidized to MOB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60053", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 => a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70194", "l": "ATP + NAD(+) <=> 3'-NADP(+) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196964", "l": "RFK:Mg2+ phosphorylates RIB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624948", "l": "KIF17 enters the cilium (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66403", "l": "ATP + glutathione(in) + glycocholate(in) + H2O <=> ADP + glutathione(out) + glycocholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "62.656265268294987", "identifiers": [{"i": "GO:0016887", "l": "ATP hydrolysis activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61831", "l": "stigmasterol + UDP-alpha-D-glucose <=> H(+) + stigmasteryl 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54897", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + ATP + CoA => (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71938", "l": "glycocholate(out) + 2 Na(+)(out) <=> glycocholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12004", "l": "indoxyl + UDP-alpha-D-glucose = H(+) + indican + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.220", "l": "\"indoxyl-UDPG glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25443", "l": "(2E,6E)-farnesyl diphosphate <=> delta-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804379", "l": "PRMT5 binds TTC5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250947", "l": "B-WICH complex binds rDNA promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24506", "l": "4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19271", "l": "2-furoyl-CoA + AMP + diphosphate => 2-furoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674140", "l": "PAQR3 binds inactive RAFs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46372", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855375", "l": "PTPN22 dissociates from CSK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30083", "l": "4 Cu(+) + 4 H(+) + O2 = 4 Cu(2+) + 2 H2O", "d": [], "t": []}, {"i": "EC:1.16.3.4", "l": "\"cuproxidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17323", "l": "2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine => L-tryptophan + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070324", "l": "thyroid hormone binding", "d": ["Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38823", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867344", "l": "OMA1 hydrolyses OPA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32364", "l": "L-gulono-1,4-lactone + O2 => H(+) + H2O2 + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53378", "l": "H(+) + NADPH + uridine(16) in tRNA => 5,6-dihydrouridine(16) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69075", "l": "H2O + O2 + serotonin <=> (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15162", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 => H2O + homogentisate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380176", "l": "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29049", "l": "a menaquinol + 2 H(+)(out) => a menaquinone + 2 H(+)(in) + H2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9866272", "l": "2Fe-2S is inserted in UQCRFS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419490", "l": "Binding of ATP to P2X receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63641", "l": "H2O + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NAD(+) => 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49955", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate <=> 5,10-dihydrophenazine 1-carboxylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74740", "l": "Binding of SHC1 to insulin receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362522", "l": "ALDHs oxidise atRAL to atRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202164", "l": "Translocation of PDK1 to Plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617492", "l": "EGR2 (KROX20) activates HOXB2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450325", "l": "c-FOS activation by phospho ERK1/2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48657", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32157", "l": "adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-methionine => 7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9674529", "l": "AAMP binds to TBXA2R (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51020", "l": "a primary alcohol + 2 Fe(III)-[cytochrome c] = an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.1.2.8", "l": "\"alcohol dehydrogenase (cytochrome c)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11613", "l": "H2O + L-glutamate + NADP(+) => 2-oxoglutarate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.36", "l": "\"leishmanolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10684", "l": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.48", "l": "\"protein-tyrosine-phosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102041", "l": "7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase", "d": ["Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphoric acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34839", "l": "4 H(+) + 5 malonyl-CoA = 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O", "d": [], "t": []}, {"i": "EC:2.3.1.216", "l": "\"5,7-dihydroxy-2-methylchromone synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390886", "l": "HRH4 binds Hist (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6794347", "l": "Homer1,2,3 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390930", "l": "5-HT2 receptor can bind serotonin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168136", "l": "NOTCH3 binds DLL4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45752", "l": "(3E)-decenoyl-CoA = (2E)-decenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9825747", "l": "CREBBP acetylates HINT1 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420883", "l": "Opsins act as GEFs for G alpha-t (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57511", "l": "H2O + NADP(+) + staphylopine <=> (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19534", "l": "2 H(+) + 2 H2O + N(2)-succinyl-L-arginine => CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-708349", "l": "Activated NOD2 oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21914", "l": "acetyl-CoA + CO2 + H2O2 => CoA + H(+) + O2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48782", "l": "ADP + H(+) + L-erythrulose 1-phosphate => ATP + L-erythrulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34753", "l": "ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate => ATP + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159773", "l": "Furin cleaves pro-protein S to protein S (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35032", "l": "L-serine(in) => L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170846", "l": "TGFBR2 recruits TGFBR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047456", "l": "2-methylisocitrate dehydratase activity", "d": ["Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24781", "l": "C-13(2)-carboxypyropheophorbide a + H(+) => CO2 + pyropheophorbide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964280", "l": "Active Gq binds BTK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445079", "l": "Phosphorylation of L1 by ERK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74680", "l": "UDP-beta-L-arabinofuranose(in) + UMP(out) => UDP-beta-L-arabinofuranose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56343", "l": "ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12650", "l": "L-rhamnofuranose + NAD(+) => H(+) + L-rhamnono-1,4-lactone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015408", "l": "ABC-type ferric iron transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114671", "l": "vWF binds to collagen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72103", "l": "Formation of pre-mRNPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74726", "l": "isorhamnetin + S-adenosyl-L-methionine <=> 3',4'-O-dimethylquercetin + 2 H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31152", "l": "H2O + L-selenocystathionine => 2-oxobutanoate + L-selenocysteine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16997", "l": "3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.31", "l": "\"petromyzonol sulfotransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36648", "l": "2-hydroxyhexadecanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46442", "l": "A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562541", "l": "TLR4-induced ripoptosome assembly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54472", "l": "1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688294", "l": "SIRT5 deacetylates Cytochrome C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72255", "l": "dopamine + S-adenosyl-L-methionine = 3-methoxytyramine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.45", "l": "\"UDP-sugar diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399941", "l": "AKT1 E17K mutant phosphorylates BAD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76353", "l": "oxaloacetate(out) + sulfate(in) => oxaloacetate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400228", "l": "BMAL1 binds CLOCK,NPAS2 forming BMAL1:CLOCK,NPAS2 heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75384", "l": "bromide(in) => bromide(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77084", "l": "O2 + pre-flavunoidine + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-pre-flavunoidine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23990", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate => (2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71167", "l": "glycine(out) + H(+)(in) + Na(+)(out) = glycine(in) + H(+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9842833", "l": "SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954056", "l": "E2F6 binds TFDP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.10", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31814", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + viridiflorene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19312", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O <=> (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25328", "l": "N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine <=> H(+) + phosphocholine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73036", "l": "Co(2+)(out) + H(+)(out) => Co(2+)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56473", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70982", "l": "FH tetramer hydrates fumarate to L-malate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018798", "l": "RHOV binds GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19872", "l": "an acyl-CoA + glycine <=> an N-acylglycine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4411373", "l": "NLK translocates to nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61356", "l": "ATP + H2O + methotrexate(in) = ADP + H(+) + methotrexate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0042900", "l": "arabinose transmembrane transporter activity", "d": ["Enables the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9007539", "l": "CHEK1 phosphorylates E2F6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848774", "l": "PTK6 binds DOK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54808", "l": "H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 = H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29028", "l": "2 H(+)(in) + L-glutamate(in) => 2 H(+)(out) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17743", "l": "3-dehydroshikimate + H(+) + NADH => NAD(+) + shikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65863", "l": "A + Delta(1)-dihydrotestosterone + H2O <=> 17beta-hydroxyandrostan-1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73736", "l": "O2 + trans-resveratrol => 3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17264", "l": "an aryl sulfate + H2O <=> a phenol + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004797", "l": "thymidine kinase activity", "d": ["Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14640", "l": "3'-phosphoadenylyl sulfate + a thiol <=> adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856808", "l": "Recruitment of AP-2 complex and clathrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.26.1", "l": "\"intramembrane prenyl-peptidase Rce1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41867", "l": "(2E)-decenoyl-[ACP] + H(+) + NADPH <=> decanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031726", "l": "CCR1 chemokine receptor binding", "d": ["Binding to a CCR1 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912470", "l": "ATR phosphorylates Histone H2A.X at unsynapsed regions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481007", "l": "Exocytosis of platelet alpha granule contents (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14902", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => casbene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49982", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine => H2O + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68037", "l": "(S)-cystathionine ketimine + 2 H(+) + NADPH => (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28425", "l": "(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0160166", "l": "2-oxoadipate dehydrogenase activity", "d": ["Catalysis of the reaction: 2-oxoadipate + H+ + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] = CO2 + N(6)-[(R)-S(8)-glutaryldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]."], "t": []}, {"i": "RHEA:69576", "l": "2-oxoadipate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] = CO2 + N(6)-[(R)-S(8)-glutaryldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013438", "l": "RHOD binds effectors at the endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50671", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19104", "l": "2-butyne-1,4-diol + NAD(+) <=> 4-hydroxy-2-butynal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30180", "l": "oxalate + oxidized 2[4Fe-4S]-[ferredoxin] => 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78685", "l": "a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+) => a 5'-end triphospho-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139913", "l": "TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696564", "l": "USP25 deubiquitinates DDX58 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159733", "l": "Furin cleaves pro-factor X to factor X (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211272", "l": "FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814094", "l": "ARL1:GTP binds ARFIP2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5685953", "l": "SIRT6 deacetylates RBBP8 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372542", "l": "Loading of dopamine into synaptic veiscles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102965", "l": "alcohol-forming long-chain fatty acyl-CoA reductase activity", "d": ["Catalysis of the reaction: a long-chain fatty acyl-CoA + 2 H+ + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16521", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21426", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH => 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19610", "l": "adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031423", "l": "hexon binding", "d": ["Binding to a hexon, the major protein component of the icosahedral capsid of an adenovirus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54322", "l": "a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004801", "l": "transaldolase activity", "d": ["Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18796", "l": "alpha-D-ribose 1-phosphate <=> D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76486", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphing-4-enine <=> 2 Fe(III)-[cytochrome b5] + 2 H2O + sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191072", "l": "Synthesis of Cx43 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38899", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373724", "l": "Nephrin binds NCK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.37", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76201", "l": "oxalate(out) => oxalate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981657", "l": "IL34 dimer binds PTPRZ1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141341", "l": "SMOX-3 oxidises SPN to SPM (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803240", "l": "Homo- or heterodimerization of RAF downstream of mutant RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74083", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + menadiol = diphosphate + menaquinol-4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168777", "l": "Metalloprotease cleavage of GHR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56753", "l": "a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30660", "l": "4-(phosphooxy)-L-threonine + H2O => 4-hydroxy-L-threonine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141367", "l": "Myristoylation of tBID by NMT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30827", "l": "UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73774", "l": "O2 + preechinulin + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + neoechinulin A + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32949", "l": "a 1,2-diacyl-sn-glycerol + CoA => a 2-acylglycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39486", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174367", "l": "GCL ligates L-Glu to L-Cys (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866941", "l": "MID1IP1 binds THRSP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57421", "l": "NADH + 2 oxidized [cytochrome P450] => H(+) + NAD(+) + 2 reduced [cytochrome P450]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047679", "l": "arginine racemase activity", "d": ["Catalysis of the reaction: L-arginine = D-arginine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77486", "l": "heptan-2-one + hydrogen cyanide <=> (2S)-2-hydroxy-2-methylheptanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39180", "l": "(2E)-eicosenoyl-CoA + H(+) + NADPH => eicosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31893", "l": "1-phenyl-1,2-propanedione + H(+) + NADPH => 2-hydroxy-1-phenyl-1-propanone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16935", "l": "2-oxobutanoate + NH4(+) => 1-aminocyclopropane-1-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15028", "l": "S-adenosyl-L-methionine + xanthosine <=> 7-methylxanthosine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77645", "l": "AMP + phosphate => adenosine 2',5'-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32492", "l": "alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176445", "l": "SMURF2 binds SMAD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034803", "l": "3-hydroxy-2-naphthoate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-naphthoate + O2 = (3E)-3-[(6Z)-6-(carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16075", "l": "CO2 + dialkyl ketone + L-alanine => 2,2-dialkylglycine + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694527", "l": "Loss of SAR1B GTPase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18369", "l": "O2 + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.21", "l": "\"glycerol-3-phosphate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16008", "l": "galactarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25554", "l": "diphosphate + stemar-13-ene => 9alpha-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10979", "l": "H(+) + NADH + O2 + quinolin-2-ol <=> 5,6-dihydroquinoline-2,5,6-triol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371582", "l": "HSBP1 binds HSF1 trimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159232", "l": "Recruitment Of HIV Virion Budding Machinery (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113429", "l": "Elongating transcript encounters a lesion in the template (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.12.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52079", "l": "13-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830435", "l": "Expression of PAX2 in the nephric duct (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19689", "l": "L-rhamnulose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}, {"i": "EC:4.1.2.19", "l": "\"rhamnulose-1-phosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167597", "l": "Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13812", "l": "aspulvinone E + 2 dimethylallyl diphosphate <=> aspulvinone H + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15486", "l": "(2R,3S)-homoisocitrate => cis-homoaconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78619", "l": "L-lysyl-5'-AMP + tRNA(Lys) = AMP + H(+) + L-lysyl-tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31461", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18811", "l": "aminomalonate + pyruvate => L-alanine + oxomalonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47765", "l": "S-adenosyl-L-methionine + uridine(1369) in 16S rRNA => 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051989", "l": "coproporphyrinogen dehydrogenase activity", "d": ["Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57251", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP <=> dGTP + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13061", "l": "O2 + S-sulfanylglutathione = glutathione S,S-dioxide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43644", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-CoA = 3-oxohexadecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11407", "l": "UDP-alpha-D-glucuronate <=> UDP-alpha-D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39416", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH => (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140381", "l": "4-hydroxytryptamine 4-phosphate methyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine (SAM) + 4-hydroxytryptamine 4-phosphate (norbaeocystin) = 2 S-adenosyl-L-homocysteine + psilocybin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432067", "l": "Aquaporin-4 passively transports water out of cell (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047515", "l": "1,3-beta-oligoglucan phosphorylase activity", "d": ["Catalysis of the reaction: [oligomeric (1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190261", "l": "FGFR3c binds to FGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34627", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0003696", "l": "satellite DNA binding", "d": ["Binding to satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53103", "l": "2-hydroxyestrone + S-adenosyl-L-methionine <=> 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40399", "l": "1,2-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36963", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953013", "l": "E2F7 binds E2F8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45204", "l": "Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol = H2O + methyl-Co(III)-[methanol-specific corrinoid protein]", "d": [], "t": []}, {"i": "EC:2.1.1.90", "l": "\"methanol--corrinoid protein Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57553", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] => (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381091", "l": "IRE1 dimer autophosphorylates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46034", "l": "(2S)-hydroxytetradecanoate + H2O => H2O2 + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35627", "l": "delphinidin 3,5-bis-O-beta-D-glucoside + UDP-alpha-D-glucose = delphinidin 3,3',5-tri-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.238", "l": "\"delphinidin 3,5-di-O-glucoside 3'-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5228992", "l": "ROCK1,ROCK2 are activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373705", "l": "Caspase cleavage of DCC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30104", "l": "2,5-didehydro-D-gluconate + H(+) + NADH => 5-dehydro-D-gluconate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047958", "l": "glycine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782820", "l": "USP17 deubiquitinates SUDS3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49617", "l": "2-hydroxy-2-methylpropanal + H2O + NAD(+) => 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38920", "l": "H2O + sphing-4-enine-phosphocholine => choline + H(+) + sphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0047606", "l": "hydroxynitrilase activity", "d": ["Catalysis of the reaction: a hydroxynitrile = cyanide + an aldehyde or ketone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17122", "l": "carbamoyl phosphate + L-lysine => H(+) + L-homocitrulline + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49308", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside nLc4Cer(d18:0) + L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035013", "l": "myosuppressin receptor activity", "d": ["Combining with the peptide myosuppressin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47695", "l": "AH2 + neomycin C + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797766", "l": "TP53 binds the BIRC5 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51943", "l": "(1E,2S)-2-methylbutanal oxime <=> (1Z,2S)-2-methylbutanal oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31817", "l": "(+)-(E)-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0032546", "l": "deoxyribonucleoside binding", "d": ["Binding to a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35036", "l": "4-aminobutanoate(in) => 4-aminobutanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0010340", "l": "carboxyl-O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592236", "l": "NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707659", "l": "Hemes:LY96 activates TLR4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6813740", "l": "GDE1 hydrolyzes GroPIns (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42916", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390649", "l": "CHRM1,3,5 bind acetylcholine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31182", "l": "(3S)-3-hydroxydodecanoyl-CoA + NAD(+) <=> 3-oxododecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12531", "l": "N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP-alpha-D-glucuronate <=> [hyaluronan](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451900", "l": "IL2RB binds JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31530", "l": "N(omega)-hydroxy-L-arginine <=> guanidine + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.794758999417795", "identifiers": [{"i": "GO:0140303", "l": "intramembrane lipid transporter activity", "d": ["Enables the transport of a lipid from a region of a membrane to a different region on the same membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42705", "l": "hercynine + L-cysteine + O2 => H2O + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26454", "l": "NADP(+) + propanoyl-CoA = acryloyl-CoA + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.84", "l": "\"acrylyl-CoA reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74037", "l": "D-serine(in) + L-alanine(out) => D-serine(out) + L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61207", "l": "L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal <=> H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.387", "l": "\"isomaltosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047166", "l": "1-alkenylglycerophosphoethanolamine O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45279", "l": "12-phosphooxy-(9E)-octadecenoate + H2O <=> 12-hydroxy-(9E)-octadecenoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0008137", "l": "NADH dehydrogenase (ubiquinone) activity", "d": ["Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63189", "l": "3,4-dihydroxybenzaldehyde + AH2 + tyramine => A + H2O + norbelladine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78210", "l": "D-methionine + H2O + O2 <=> 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214398", "l": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75656", "l": "(9Z)-octadecenoate + O2 => (8R)-hydroperoxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73550", "l": "GTP(out) + UTP(in) <=> GTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47596", "l": "an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.335", "l": "\"dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36375", "l": "ATP + carbamoyl phosphate + H2O = carbamoyl adenylate + diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47277", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47988", "l": "2-dehydro-3-deoxy-L-galactonate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.389", "l": "\"2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008674", "l": "2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity", "d": ["Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31348", "l": "(+)-abscisic acid D-glucopyranosyl ester + H2O => 2-cis-(+)-abscisate + beta-D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18748", "l": "2 juglone + O2 <=> 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9727607", "l": "MME:Zn2+ binds sacubitrilat (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610735", "l": "NUMB binds ITCH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047946", "l": "glutamine N-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042498", "l": "diacyl lipopeptide binding", "d": ["Binding to a lipopeptide containing a nonprotein moiety consisting of two acyl groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796617", "l": "MIB2 binds CFLAR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36655", "l": "desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine = descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.285", "l": "\"demethyldecarbamoylnovobiocin O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450494", "l": "HuR binds mRNAs in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5444523", "l": "Formation of MSH1:PMS2 Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858651", "l": "MITF-M-dependent expression of CDKN2A gene product 16INK4A  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73012", "l": "L-leucine(in) => L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1362416", "l": "Frataxin binds iron (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36438", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(in) <=> a 1,2-diacyl-sn-glycero-3-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20564", "l": "3-hydroxypyruvate + H(+) <=> CO2 + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12789", "l": "an alditol + NADP(+) = an aldose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11537", "l": "choline + H2O + 2 O2 => glycine betaine + H(+) + 2 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57070", "l": "3-oxoisoapionate 4-phosphate + ADP + H(+) => 3-oxoisoapionate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36379", "l": "3-dehydro-4alpha-methylzymosterol + H(+) + NADPH = 4alpha-methylzymosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.139", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168297", "l": "Recognition of the Nuclear Localization Signal (NLS) by a Karyopherin Alpha Family Protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24330", "l": "10-formyldihydrofolate + ADP + phosphate => 7,8-dihydrofolate + ATP + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008577", "l": "IL37:IL18R1 binds SIGIRR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68095", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA <=> a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54364", "l": "2 acetaldehyde = acetoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871196", "l": "Initial binding of AP-2 and clathrin to PI(4,5)P2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111264", "l": "Addition of nucleotides between position +11 and +30 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50775", "l": "H2O + nitroethane + O2 <=> acetaldehyde + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72628", "l": "2 H(+)(out) + Zn(2+)(in) => 2 H(+)(in) + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839112", "l": "Phosphorylation of STAT5 by cytosolic FGFR1 fusions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9856510", "l": "STARD7 transports Q10 to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789092", "l": "NOX2 generates superoxide anion from oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49191", "l": "a bacteriochlorophyllide d <=> a 3-vinylbacteriochlorophyllide d + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72128", "l": "agmatine(in) + H(+)(out) => agmatine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0019862", "l": "IgA binding", "d": ["Binding to an immunoglobulin of an IgA isotype."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59345", "l": "D-maltose + O2 => D-maltobiono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65087", "l": "asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-372448", "l": "SLC25A12,13 exchange L-Glu and L-Asp (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015520", "l": "tetracycline:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834076", "l": "PINK1 is autophosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953111", "l": "E2F6 binds TFDP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033520", "l": "TYSND1 cleaves TYSND1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690873", "l": "ACO1 binds 4Fe-4S (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21505", "l": "acetoin + aldehydo-D-ribose 5-phosphate => 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8857686", "l": "FITM1, FITM2 bind TAGs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39454", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA <=> (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76447", "l": "ATP + L-aspartate + L-methionine = ADP + H(+) + L-aspartyl-L-methionine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195275", "l": "Phosphorylation of APC component of the destruction complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63086", "l": "FAD + H(+) + 2 H2O + ilicicolin A => chloride + FADH2 + ilicicolin B + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25074", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.92", "l": "\"hydroperoxide dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64657", "l": "(E)-sinapaldehyde + CoA + NADP(+) => (E)-sinapoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018658", "l": "salicylate 1-monooxygenase activity", "d": ["Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.22", "l": "\"cyclin-dependent kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102119", "l": "gibberellin A20 carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: gibberellin A20 + S-adenosyl-L-methionine = gibberellin A20 methyl ester + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41491", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400204", "l": "PPARA binds RXRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9680443", "l": "ROCK1,2 bind ROCKi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23087", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 7-methyl-3-oxooct-6-enoyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18493", "l": "benzoyl-CoA + glycine = CoA + H(+) + N-benzoylglycine", "d": [], "t": []}, {"i": "EC:2.3.1.71", "l": "\"glycine N-benzoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66825", "l": "2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656070", "l": "FGFBPs bind FGFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031849", "l": "olfactory receptor binding", "d": ["Binding to an olfactory receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1458485", "l": "RALA hydrolyzes GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64026", "l": "H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71191", "l": "an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0050521", "l": "alpha-glucan, water dikinase activity", "d": ["Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622572", "l": "NF-Y and CREBBP,EP300 constitutively bind BCL2L11 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15981", "l": "H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}, {"i": "EC:4.1.1.50", "l": "\"adenosylmethionine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34238", "l": "4-nitro-6-oxohepta-2,4-dienedioate <=> 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47654", "l": "phosphate + ribitol => D-ribitol 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71703", "l": "taurocholate(out) = taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102839", "l": "1-18:2-2-16:2-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36282", "l": "H(+) + NADH + O2 + theophylline <=> 3-methylxanthine + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26279", "l": "Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-4 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23447", "l": "(S)-lactate + NAD(+) <=> H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592371", "l": "Initial activation of proMMP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55388", "l": "(3R)-3-hydroxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41826", "l": "(3R)-hydroxyhexanoyl-[ACP] + NADP(+) => 3-oxohexanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299359", "l": "Activation of TALK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390663", "l": "ADRA2A,B,C bind ADR,NAd (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73927", "l": "griseophenone D + S-adenosyl-L-methionine = griseophenone C + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62376", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H2O = (S)-lactate + H(+) + pyruvate", "d": [], "t": []}, {"i": "EC:3.7.1.26", "l": "\"2,4-didehydro-3-deoxy-L-rhamnonate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53275", "l": "5-dehydro-L-gluconate <=> keto-D-tagaturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39772", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48930", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71224", "l": "chloride(out) + 2 Na(+)(out) + taurine(out) => chloride(in) + 2 Na(+)(in) + taurine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32728", "l": "a very-long-chain acyl-CoA + H(+) + malonyl-CoA => a very-long-chain 3-oxoacyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49134", "l": "an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112392", "l": "Resumption of elongation after recovery from pausing (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379893", "l": "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27777", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77094", "l": "Formation of cap binding complex (CBC) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783880", "l": "PIPOX oxidises PPCA to P6C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71275", "l": "2 Na(+)(out) + taurolithocholate 3-sulfate(out) = 2 Na(+)(in) + taurolithocholate 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12035", "l": "a 3-(acyloxy)acyl derivative of bacterial toxin + H2O <=> 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67635", "l": "a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin] <=> a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56855", "l": "reumycin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + toxoflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27427", "l": "(E)-beta-farnesene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51380", "l": "(9Z)-octadecenoyl-CoA + dopamine = CoA + H(+) + N-(9Z-octadecanoyl)-dopamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54746", "l": "18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62456", "l": "ATP + H(+) + L-glutamate = diphosphate + L-glutamyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140605", "l": "proton motive force-driven motor activity", "d": ["A motor activity driven by an electrochemical proton gradient (proton-motive force). PMF-driven motors are used by bacterial flagella."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603297", "l": "Defective SLC35D1 does not transport UDP-GlcA, UDPGlcNAc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30840", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-talose => UDP-N-acetyl-beta-L-fucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51264", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] = (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22688", "l": "D-alanine + H2O + O2 = H2O2 + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38262", "l": "(2R,3S)-beta-methylmalyl-CoA <=> glyoxylate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39586", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.4", "l": "\"chymosin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77867", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-leucine + O2 = 2-dehydro-D-glucose + H2O2 + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215406", "l": "PRMT5 binds WDR77 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.53", "l": "\"beta-N-acetylgalactosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62263", "l": "2 hydrogencarbonate(out) + Mn(2+)(out) <=> 2 hydrogencarbonate(in) + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27579", "l": "(R)-N-tert-butylpiperazine-2-carboxamide + H2O => (R)-piperazine-2-carboxylate + tert-butylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72865", "l": "G[3'-5']pA[3'-5']pAp[3'] + H(+) => 3',3',3'-cAAG + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705584", "l": "HMGCR dimer binds statins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50693", "l": "ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate => ADP + alpha-maltose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434018", "l": "Autophosphorylation of chicken IRAK4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989761", "l": "Expression of APOA5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857928", "l": "GPIHBP1 binds HSPG:LPL dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72321", "l": "n chloride(out) + urate(in) => n chloride(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446221", "l": "GMPPB converts Mannose-1-phosphate to GDP-Mannose (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624112", "l": "CEBPA binds CDK4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196857", "l": "PANK2 phosphorylates PanK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11883", "l": "(S)-6-hydroxynicotine + H2O + O2 <=> 6-hydroxypseudooxynicotine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42557", "l": "uridine(2819) in 21S rRNA => pseudouridine(2819) in 21S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71108", "l": "L-leucine(out) + S-methylmercury-L-cysteine(in) => L-leucine(in) + S-methylmercury-L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614271", "l": "Autocleavage of ADGRG6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043262", "l": "ADP phosphatase activity", "d": ["Catalysis of the reaction: ADP + H2O = AMP + phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12555", "l": "(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> (E)-pinosylvin + 4 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53311", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15223", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+) => a CDP-1,2-diacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64884", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP = (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951499", "l": "Loading of antigenic peptides on to class I MHC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22433", "l": "a (3S)-3-hydroxyacyl-CoA + NAD(+) => a 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55896", "l": "chloride + FADH2 + L-tryptophan + O2 = 5-chloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.58", "l": "\"tryptophan 5-halogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853793", "l": "p-5Y-RET complexes bind GRB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61394", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] => ATP + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73357", "l": "carcinine + H(+) + holo-[peptidyl-carrier protein] => beta-alanyl-[peptidyl-carrier protein] + histamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69596", "l": "AMP + inosine = adenosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661625", "l": "FVIII is secreted (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371353", "l": "Soluble TNF-α binds TNFR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28057", "l": "2-oxobutanoate + CoA <=> formate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41027", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + tetradecanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-tetradecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.184", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635609", "l": "Rv3655c binds RNF213 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-141367", "l": "Myristoylation of tBID by NMT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848124", "l": "PTK6 phosphorylates STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33494", "l": "2-hydroxyhexacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45033", "l": "4 Fe(III)-[cytochrome c] + H2O + hydroxylamine => 4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3204303", "l": "MRE11 binds cytosolic DNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35820", "l": "5,6,7,8-tetrahydromethanopterin + NADP(+) => 7,8-dihydromethanopterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72678", "l": "3',5'-cyclic CMP + H2O <=> CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174121", "l": "Association of Securin with Cdc20:APC/C complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69519", "l": "N-acetyl-D-galactosamine + O2 <=> H2O2 + N-acetyl-D-galactosamino-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46133", "l": "cholesterol + H(+) + NADPH + O2 => 25-hydroxycholesterol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047475", "l": "phenylacetate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H+ + phenylacetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50300", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45512", "l": "phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173636", "l": "Formation of classic pathway C5 convertase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14855", "l": "4-hydroxybenzoyl-CoA + chloride + H(+) => 4-chlorobenzoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48756", "l": "erythritol + NAD(+) = D-erythrulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400434", "l": "FFAR1 binds fatty acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63593", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77580", "l": "(9Z)-octadecenoyl-CoA + 1-octanoylglycerol => 1-octanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52465", "l": "17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62440", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) = 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)", "d": [], "t": []}, {"i": "EC:4.2.2.27", "l": "\"pectin monosaccharide-lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58802", "l": "5'-pApG-3' + H(+) => 3',3'-cGAMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29745", "l": "2-phenylethylamine(out) => 2-phenylethylamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047399", "l": "glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13615", "l": "beta-D-fructose 1,6-bisphosphate + H(+) + phosphate => beta-D-fructose 6-phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46117", "l": "2-dehydro-3-deoxy-D-galactonate => D-glyceraldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16948", "l": "(6S)-5,6,7,8-tetrahydrofolate + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70535", "l": "GDP-beta-L-fucose + L-seryl-[EGF-like domain protein] = 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956140", "l": "NEDD8 and UBD bind NUB1 and the 26S proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655837", "l": "Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042615", "l": "CD154 receptor binding", "d": ["Binding to CD154, a receptor found on the surface of some activated lymphocytes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19194", "l": "A + all-trans-13,14-dihydroretinol => AH2 + all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032798", "l": "DOCK3 activates RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.-.-", "l": "\"Intramolecular lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371360", "l": "FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16111", "l": "ADP + beta-D-fructose 1,6-bisphosphate + H(+) => ATP + beta-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63273", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 => 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033812", "l": "3-oxoadipyl-CoA thiolase activity", "d": ["Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709787", "l": "SARS-CoV-1 9b binds TOMM70 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10914", "l": "(R)-pantothenate + AMP + diphosphate + H(+) => (R)-pantoate + ATP + beta-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25001", "l": "H(+) + N,N-dihydroxy-L-phenylalanine => (E)-phenylacetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26514", "l": "cyclohexan-1,2-dione + H2O = 6-oxohexanoate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.11", "l": "\"cyclohexane-1,2-dione hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050285", "l": "sinapine esterase activity", "d": ["Catalysis of the reaction: O-sinapoylcholine + H2O = choline + H+ + sinapate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6813749", "l": "ALDH1A1 oxidises GA to DGA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67221", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+) => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54945", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64742", "l": "3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate => H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102004", "l": "2-octaprenyl-6-hydroxyphenol methylase activity", "d": ["Catalysis of the reaction: 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = H+ + 2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.1", "l": "\"succinate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706328", "l": "Active FLT3 binds to SOCS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22768", "l": "4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one", "d": [], "t": []}, {"i": "EC:4.3.3.1", "l": "\"3-ketovalidoxylamine C-N-lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336443", "l": "LIN7, CASK and APBA1 bind (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50899", "l": "8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O <=> (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52000", "l": "a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + glutathione = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044508", "l": "glucagon-like peptide 1 receptor activity", "d": ["Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73729", "l": "(2S,3R,11R)-aszonalenin + diphosphate => (R)-benzodiazepinedione + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35841", "l": "a cardiolipin + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25029", "l": "ADP-alpha-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.84", "l": "\"ADP-ribose 1''-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67061", "l": "asnovolin I + S-adenosyl-L-methionine => asnovolin K + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12424", "l": "(3S)-3-hydroxy-L-aspartate = NH4(+) + oxaloacetate", "d": [], "t": []}, {"i": "EC:4.3.1.16", "l": "\"threo-3-hydroxy-L-aspartate ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51808", "l": "(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63574", "l": "L-arginine + neurotensin-(1-7) => H2O + neurotensin-(1-8)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48383", "l": "alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose <=> a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395764", "l": "atREs binds to nascent CM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.9", "l": "\"dihydroxy-acid dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29677", "l": "glycerol(out) => glycerol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938356", "l": "RMB14 binds RUNX2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25912", "l": "A + H2O + quinolin-5-ol = 5-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805740", "l": "SETD8 methylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617326", "l": "CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2484822", "l": "Kinetochore assembly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41949", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4539779", "l": "Collagen type IV binds integrin alpha10beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73267", "l": "H(+)(out) + L-methionine(in) = H(+)(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42759", "l": "cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13896", "l": "H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate <=> ADP + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68825", "l": "Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31019", "l": "4 AH2 + all-trans-4,4'-diapolycopene + 4 O2 = 4 A + all-trans-4,4'-diapolycopene-4,4'-dial + 6 H2O", "d": [], "t": []}, {"i": "EC:1.14.99.44", "l": "\"diapolycopene oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20230", "l": "2,3-dihydroxybenzoate + ATP + H(+) => 2,3-dihydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051908", "l": "double-stranded DNA 5'-3' DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule."], "t": []}, {"i": "EC:3.1.11.3", "l": "\"exodeoxyribonuclease (lambda-induced)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10894", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH => (2R,3S)-3-isopropylmalate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26550", "l": "(S)-piperazine-2-carboxamide + H2O = (S)-piperazine-2-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788622", "l": "p-Y-STATs dimerize (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982617", "l": "CYGB:O2 dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28911", "l": "H(+)(out) + L-lysine(out) = H(+)(in) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070551", "l": "endoribonuclease activity, cleaving siRNA-paired mRNA", "d": ["Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters."], "t": []}, {"i": "REACT:R-HSA-9820842", "l": "AGO2:endosiRNA hydrolyzes maternal mRNA in the zygote (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31156", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) => (4S)-4-hydroxy-L-glutamate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004342", "l": "glucosamine-6-phosphate deaminase activity", "d": ["Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40396", "l": "1,2-dihydro-beta-NAD + H(+) + O2 => H2O2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42087", "l": "9-cis-retinal + H2O + NAD(+) <=> 9-cis-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66968", "l": "alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.380", "l": "\"GDP-Man:alpha-D-Man-(1->3)-alpha-D-Gal diphosphoundecaprenol alpha-1,2-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78878", "l": "a medium-chain (3R)-hydroxyacyl-CoA + NAD(+) <=> a medium-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68474", "l": "(E)-alpha-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45397", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50774", "l": "acetaldehyde + H(+) + H2O2 + nitrite => H2O + nitroethane + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50037", "l": "choloyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42118", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH => 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50268", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34922", "l": "thiamine(in) <=> thiamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54499", "l": "ent-copalyl diphosphate <=> diphosphate + ent-atiserene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030755", "l": "quercetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12250", "l": "H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine => NADP(+) + UDP-N-acetyl-alpha-D-muramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21832", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',5-dihydroxy-3,4',7-trimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.83", "l": "\"3,7-dimethylquercetin 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64235", "l": "8 H(+) + holo-[ACP] + 8 malonyl-CoA <=> atrochrysone carboxyl-[ACP] + 8 CO2 + 8 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685597", "l": "RTC binds SARS-CoV-1 genomic RNA complement (minus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38842", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1467466", "l": "ABCA4 mediates atRAL transport (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693061", "l": "STAMBP binds STAM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10943", "l": "(2E)-geranyl diphosphate <=> (4R)-limonene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10045", "l": "cyclohexanol + NAD(+) => cyclohexanone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68616", "l": "cortisone + H(+) + NADPH = cortisol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40280", "l": "(R)-carnitine + dodecanoyl-CoA => CoA + O-dodecanoyl-R-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33586", "l": "L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate <=> 2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13948", "l": "(S)-mandelate <=> (R)-mandelate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9724685", "l": "IgE binds omalizumab (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22380", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol", "d": [], "t": []}, {"i": "EC:3.1.1.11", "l": "\"pectinesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870461", "l": "RABGGTA and RABGGTB bind (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41147", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806613", "l": "Keratin tetramers bind to form unit length filaments (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177934", "l": "EGFR autophosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28113", "l": "chloride + S-adenosyl-L-methionine <=> 5'-chloro-5'-deoxyadenosine + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78989", "l": "cattleyene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002428", "l": "Removal of fibrillar collagen N-propeptides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878266", "l": "IHH gene transcription is stimulated by RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156682", "l": "PLK1 phosphorylates NUDC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53708", "l": "(2E)-decenoyl-CoA + NADP(+) = (2E,4Z)-decadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52764", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O = (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351876", "l": "Caspase-mediated cleavage of occludin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52497", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15520", "l": "H2O + N(2),6-disulfo-D-glucosamine <=> H(+) + N-sulfo-D-glucosamine + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012835", "l": "GDIs block activation of RHOA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944242", "l": "Association of procollagen type XXVII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0051032", "l": "nucleic acid transmembrane transporter activity", "d": ["Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0050811", "l": "GABA receptor binding", "d": ["Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76322", "l": "L-aspartate(in) + L-leucine(out) <=> L-aspartate(out) + L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53435", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65446", "l": "CoA + hexyl butanoate => butanoyl-CoA + hexan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2219524", "l": "PDPK1 binds PIP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65368", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O = a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983421", "l": "Journey of cargo through Golgi complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018826", "l": "RHOT2 hydrolyzes GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32618", "l": "(6E)-8-oxogeraniol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73654", "l": "CTP(out) <=> CTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18407", "l": "H(+) + NADH + NH4(+) + pyruvate => H2O + L-alanine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0051010", "l": "microtubule plus-end binding", "d": ["Binding to the plus end of a microtubule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51197", "l": "chloride(out) + Na(+)(out) + serotonin(out) => chloride(in) + Na(+)(in) + serotonin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607043", "l": "factor VIIIa associates with cell membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2167942", "l": "Collagen type XIII ectodomain shedding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26092", "l": "(4S)-limonene + H(+) + NADH + O2 <=> H2O + limonene 1,2-epoxide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38955", "l": "an N-acylsphing-4-enine 1-phosphate(in) = an N-acylsphing-4-enine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24447", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] <=> GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983700", "l": "SYK binds the activated BCR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17242", "l": "an alpha-amino acid ester + H2O => an alcohol + an alpha-amino acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0045511", "l": "interleukin-25 binding", "d": ["Binding to interleukin-25."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51136", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 = (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40759", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43226", "l": "(24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75438", "l": "32-oxoeburicol + O2 + reduced [NADPH--hemoprotein reductase] <=> 14-demethyleburicol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26438", "l": "3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.298", "l": "\"3-hydroxypropionate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50791", "l": "NADP(+) + pentan-2-one <=> (E)-pent-3-en-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74823", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15106", "l": "kaempferol + S-adenosyl-L-methionine => H(+) + kaempferide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050481", "l": "mandelate 4-monooxygenase activity", "d": ["Catalysis of the reaction: (S)-mandelate + 5,6,7,8-tetrahydrobiopterin + O2 = (S)-4-hydroxymandelate + 7,8-dihydrobiopterin + H2O. (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11813", "l": "H2O + methanethiol + O2 => formaldehyde + H(+) + H2O2 + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66019", "l": "bromide + H2O2 <=> H2O + hypobromite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2247513", "l": "STAB1:ligand is endocytosed (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698033", "l": "p-STAT5 translocates to nucleus downstream of mutant FLT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005366", "l": "myo-inositol:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37293", "l": "L-alanine + L-leucine => H2O + L-alanyl-L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38659", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0008525", "l": "phosphatidylcholine transporter activity", "d": ["Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052821", "l": "DNA-7-methyladenine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75559", "l": "erinacol + O2 + reduced [NADPH--hemoprotein reductase] = cyathadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296326", "l": "HCAR1 binds LACT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0016300", "l": "tRNA (uridine) methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008190", "l": "eukaryotic initiation factor 4E binding", "d": ["Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11393", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O => 1D-myo-inositol 1,3,4-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74284", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IIA => a 2-acyl-sn-glycero-3-phosphocholine + a lipid IIB", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.773497473658765", "identifiers": [{"i": "GO:0050664", "l": "oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule."], "t": []}, {"i": "EC:1.6.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112379", "l": "Recruitment of elongation factors to form elongation complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76456", "l": "O-atom dealkylation of dextromethorphan (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428609", "l": "Type I Na+-coupled phosphate co-transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48583", "l": "[pyruvate, water dikinase]-phosphate + H(+) + phosphate <=> [pyruvate, water dikinase] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016402", "l": "pristanoyl-CoA oxidase activity", "d": ["Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51573", "l": "(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31671", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine = dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.235", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24804", "l": "2-oxoglutarate + L-isoleucine <=> (S)-3-methyl-2-oxopentanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64877", "l": "H2O + UDP => H(+) + phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30853", "l": "D-glyceraldehyde + dihydroxyacetone phosphate => beta-D-fructose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604553", "l": "HEY2 gene expression is stimulated by NOTCH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9681375", "l": "KIT binds ripretinib (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008818", "l": "cobalamin 5'-phosphate synthase activity", "d": ["Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75473", "l": "thiamine diphosphate(in) => thiamine diphosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65590", "l": "4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-casbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52582", "l": "ADP + H(+) + Pb(2+)(out) + phosphate => ATP + H2O + Pb(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36241", "l": "1-O-alkyl-2-acyl-sn-glycerol + phosphate => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27504", "l": "3',5'-di-O-methyltricetin + S-adenosyl-L-methionine <=> 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034549", "l": "N-cyclopropylammelide alkylamino hydrolase activity", "d": ["Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2430552", "l": "p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34888", "l": "selenate(in) => selenate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28579", "l": "Co(2+)(in) => Co(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9656947", "l": "OGG1beta translocates to mitochondria (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37285", "l": "L-alanine + L-histidine => H2O + L-alanyl-L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429955", "l": "CCR4-NOT complex deadenylates mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43652", "l": "decanoyl-CoA + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46233", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12223", "l": "H2O + L-leucine + NAD(+) <=> 4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53064", "l": "2-methoxyestrone + UDP-alpha-D-glucuronate = 2-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63999", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731924", "l": "EDNRA binds EDNs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.38", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47527", "l": "cholate + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18964", "l": "D-allose + L-lysyl-[protein] <=> H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196929", "l": "FLAD1 phosphorylates FMN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65406", "l": "butyl hexanoate + CoA => butan-1-ol + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65040", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52022", "l": "A + H2O + resolvin E2 => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52438", "l": "2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA => a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953037", "l": "E2F8 forms homodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76304", "l": "L-cystine(out) => L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64855", "l": "benzoyl-CoA + octan-1-ol <=> CoA + octyl benzoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56688", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.9", "l": "\"tyrosine isonitrile desaturase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29184", "l": "menaquinol-8 + 2 O2 => 2 H(+) + menaquinone-8 + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29177", "l": "2 H(+) + 2 superoxide + ubiquinone-8 => 2 O2 + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45181", "l": "2 (E)-4-coumaroyl-CoA + spermidine => 2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50577", "l": "acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023632", "l": "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32480", "l": "2 iodide + L-tyrosine + 2 NADP(+) => 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53105", "l": "4-hydroxyestrone + S-adenosyl-L-methionine => 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63561", "l": "angiotensin I + H2O => angiotensin II + L-histidyl-L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11961", "l": "2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate => (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004449", "l": "isocitrate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17248", "l": "3-hydroxyanthranilate + O2 <=> 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76028", "l": "(S)-reticuline + 2-oxoglutarate + O2 => (S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30306", "l": "(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23217", "l": "benzoyl-CoA + H(+) + NADPH + O2 => 3-hydroxybenzoyl-CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32009", "l": "diphosphate + isopimara-8(14),15-diene => 9alpha-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669024", "l": "CD70 binds CD27 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696822", "l": "AKR1B15 reduces EST17b to E1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67249", "l": "(E)-4-hydroxynon-2-enal + H2O + NAD(+) => (E)-4-hydroxynon-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610752", "l": "GLI3R translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37196", "l": "octadecanoyl-CoA + sn-glycerol 3-phosphate => 1-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371527", "l": "HSF1 trimer translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20786", "l": "ADP-D-ribose + L-arginine => H2O + N(omega)-(ADP-D-ribosyl)-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10982", "l": "D-serine => L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173636", "l": "Formation of classic pathway C5 convertase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64899", "l": "2 H2O + UTP <=> 2 H(+) + 2 phosphate + UMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44395", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981621", "l": "C3 convertases spontaneously dissociate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47144", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29991", "l": "H(+)(in) + L-lyxopyranose(in) = H(+)(out) + L-lyxopyranose(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18105", "l": "ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.10", "l": "\"P-type Ca(2+) transporter\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847968", "l": "PTEN binds FRK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534378", "l": "Hv1 Mediated H+ Permeability (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848392", "l": "IL18BP binds IL18 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49978", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine => butanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64843", "l": "2-phenylethanol + benzoyl-CoA <=> CoA + phenethyl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14046", "l": "1-carboxyvinyl carboxyphosphonate + H(+) => 3-(hydrohydroxyphosphoryl)pyruvate + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709317", "l": "CO binds to free ferrohemoglobin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17291", "l": "beta-D-fructose 6-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021068", "l": "PalmS-ESRs bind CAVs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669023", "l": "TWEAK binds FN14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9839358", "l": "Endocytosis of TGFBR3:ARRB complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40783", "l": "docosanoyl-CoA + H2O = CoA + docosanoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5626549", "l": "IQGAPs bind CALM1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69569", "l": "(2S)-2-amino-4-deoxychorismate + H2O + L-glutamine => 4-amino-4-deoxychorismate + L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70086", "l": "hydroxyclavatol <=> H2O + o-quinone methide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209072", "l": "PLL kinase binds to TL:MYD88:TUB 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655193", "l": "KIAA0101 double monoubiquitination (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34124", "l": "3,5,7-trioxododecanoyl-CoA => CoA + H(+) + olivetolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35000", "l": "ADP(in) + ATP(out) => ADP(out) + ATP(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247849", "l": "WLS dissociates from retromer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190687", "l": "Connexin oligomerization in  ER-Golgi-Intermediate Compartment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54203", "l": "N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043796", "l": "glyceraldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11222", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44641", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP => a 2'-deoxyribonucleoside 5'-triphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374331", "l": "Bradykinin receptors B1 and B2 bind to bradykinin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5213462", "l": "RIPK3 binds RIPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675947", "l": "TNFSF18 binds TNFRSF18 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32679", "l": "(2E)-geranyl diphosphate + H2O = (2E)-geraniol + diphosphate", "d": [], "t": []}, {"i": "EC:3.1.7.11", "l": "\"geranyl diphosphate diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209185", "l": "Monomeric PGN bound PGRP-LCx heterodimerises with PGRP-LCa at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28371", "l": "oxaloacetate + phosphate => hydrogencarbonate + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445705", "l": "Release Of ADP From Myosin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6795290", "l": "TORC2 complex phosphorylates SGK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391939", "l": "TP receptor can bind thromboxane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813749", "l": "ALDH1A1 oxidises GA to DGA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55143", "l": "D-alanyl-5'-AMP + holo-[D-alanyl-carrier protein] <=> AMP + D-alanyl-[D-alanyl-carrier protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70692", "l": "ornithine => putrescine + CO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70692", "l": "chloride(out) + glycine(out) + 2 Na(+)(out) => chloride(in) + glycine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68305", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] => 3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57337", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose => 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687465", "l": "MRN complex binds RBBP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28218", "l": "chloride + H(+) + H2O2 = H2O + hypochlorous acid", "d": [], "t": []}, {"i": "EC:1.11.2.2", "l": "\"myeloperoxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51062", "l": "AH2 + androsta-1,4-diene-3,17-dione => 5alpha-androst-1-ene-3,17-dione + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15152", "l": "O2 + pyridoxine 5'-phosphate <=> H2O2 + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66728", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827993", "l": "Expression of PDPN in primordial germ cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50212", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16674", "l": "3-phosphonopyruvate + H2O => H(+) + phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38213", "l": "1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA => hexadecane-1,2-diol + 2 hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73916", "l": "acetyl-CoA + 4 H(+) + 6 malonyl-CoA => 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + 6 CO2 + 7 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729542", "l": "OTOP1 transports H+ from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30406", "l": "Fe(3+)(out) + L-ascorbate(in) <=> Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803527", "l": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11937", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + trans-resveratrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15206", "l": "a dolichyl diphosphooligosaccharide + H2O => a dolichyl phosphate + an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78058", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine <=> 2-(acylamino)ethyl fatty acid + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632871", "l": "Defective SLC2A10 does not transport Glc from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40117", "l": "CoA + H(+) + hexanoate => H2O + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76749", "l": "9-hexadecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexadecane + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13385", "l": "3-oxododecanoate + H(+) = 2-undecanone + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.56", "l": "\"3-oxolaurate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31552", "l": "presqualene diphosphate => 15-cis-4,4'-diapophytoene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399935", "l": "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42838", "l": "5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 4 H2O + 3 NADP(+) => acetyl-CoA + 7 H(+) + 5 malonyl-CoA + 3 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633742", "l": "EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33499", "l": "H(+) + prephenate = 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.100", "l": "\"prephenate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46457", "l": "5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH => 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004355", "l": "glutamate synthase (NADPH) activity", "d": ["Catalysis of the reaction: 2 L-glutamate + NADP+ = 2-oxoglutarate + L-glutamine + H+ + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51541", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690395", "l": "SOX9 binds the SOX9 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15752", "l": "(S)-mandelate + A <=> AH2 + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23620", "l": "ATP + N(2)-(2-carboxyethyl)-L-arginine = AMP + deoxyamidinoproclavaminate + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.3.4", "l": "\"(carboxyethyl)arginine beta-lactam-synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46681", "l": "2 Fe(III)-[cytochrome b5] + NADH => 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50970", "l": "inosine(37) in tRNA(Ala) + NH4(+) => adenosine(37) in tRNA(Ala) + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61808", "l": "holo-[peptidyl-carrier protein] + L-alanyl-5'-AMP = AMP + H(+) + L-alanyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69985", "l": "3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0051011", "l": "microtubule minus-end binding", "d": ["Binding to the minus end of a microtubule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46690", "l": "3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2 => (25S)-3-oxocholest-4-en-26-oyl-CoA + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42213", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O => a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27754", "l": "H2O + methylglyoxal = (R)-lactate + H(+)", "d": [], "t": []}, {"i": "EC:4.2.1.130", "l": "\"D-lactate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10474", "l": "propanoate + pyruvate => (2R,3S)-2,3-dimethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9853376", "l": "FIGNL1 binds SPIDR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23616", "l": "1,2-dihydro-alpha-santonin + NADP(+) = alpha-santonin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641205", "l": "RSPO:LGR binds ZNRF3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33838", "l": "H2O + N-hexacosanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + hexacosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617829", "l": "Assembly of IFT A complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11630", "l": "an aldehyde + CO2 => a 2-oxocarboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39609", "l": "(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+) => (2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67455", "l": "a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O <=> 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.539730406838608", "identifiers": [{"i": "GO:0016817", "l": "hydrolase activity, acting on acid anhydrides", "d": ["Catalysis of the hydrolysis of any acid anhydride."], "t": []}, {"i": "EC:3.6.-.-", "l": "\"Acting on acid anhydrides\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14230", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796051", "l": "AcK-NFE2L2 binds the AREG gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34530", "l": "L-phenylalanine <=> (S)-3-amino-3-phenylpropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.02616462956729", "identifiers": [{"i": "GO:0016801", "l": "hydrolase activity, acting on ether bonds", "d": ["Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively."], "t": []}, {"i": "EC:3.3.-.-", "l": "\"Acting on ether bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20165", "l": "H2O + N(5)-acyl-L-ornithine ester = an alcohol + H(+) + N(5)-acyl-L-ornithine", "d": [], "t": []}, {"i": "EC:3.1.1.48", "l": "\"fusarinine-C ornithinesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37274", "l": "ATP + H2O + L-alanyl-L-glutamine(out) <=> ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58909", "l": "7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH => C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78502", "l": "CMP-5'-(N-acetyl-N-hydroxy-3-aminopropyl)phosphonate + H2O <=> 3-(N-acetyl-N-hydroxy)aminopropylphosphonate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31351", "l": "lupan-3beta,20-diol = (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.128", "l": "\"lupan-3beta,20-diol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63146", "l": "(15Z)-tetracosenoate + ethanolamine => H2O + N-(15Z-tetracosenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804527", "l": "INTL1 binds bacterial glycans (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390184", "l": "YKI binds to SD and activates transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75706", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate <=> 14,15-epoxy-12-hydroxy-(10E)-eicosenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10076", "l": "H2O + lactose = beta-D-galactose + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.108", "l": "\"lactase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451377", "l": "Interaction of IQGAP1 with nephrin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222376", "l": "NOX2 generates superoxide from oxygen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10110", "l": "H(+) + NADPH + salutaridine => (7S)-salutaridinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66720", "l": "ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in) = ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419157", "l": "5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10663", "l": "L-seryl-[protein] <=> D-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050437", "l": "(-)-endo-fenchol synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = (-)-endo-fenchol + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77125", "l": "1D-myo-inositol 1,2,3-trisphosphate + phosphate => 1D-myo-inositol 1,2,3,6-tetrakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56596", "l": "(1S,4S)-bornane-2,5-dione + FMNH2 + O2 = (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.155", "l": "\"3,6-diketocamphane 1,2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050510", "l": "N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63426", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + diphosphate => (2S)-2-phospholactate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045129", "l": "NAD-independent histone deacetylase activity", "d": ["Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010855", "l": "adenylate cyclase inhibitor activity", "d": ["Binds to and decreases the activity of adenylate cyclase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45433", "l": "H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627104", "l": "XIAP binds CASP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41032", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72728", "l": "UDP-alpha-D-glucuronate(in) + UMP(out) => UDP-alpha-D-glucuronate(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36420", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine => 2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623415", "l": "FOXO1,FOXO3,FOXO4 bind IGFBP1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578777", "l": "DMPK phosphorylates PLN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72561", "l": "estrone 3-sulfate(in) + pentanoate(out) => estrone 3-sulfate(out) + pentanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38136", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45050", "l": "acetate + NH4(+) => acetamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0018169", "l": "ribosomal S6-glutamic acid ligase activity", "d": ["Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34655", "l": "C30 botryococcene + 2 S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.263", "l": "\"botryococcene C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69527", "l": "D-sorbitol + O2 <=> D-glucose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43923", "l": "(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27838", "l": "9H-carbazole + H(+) + NADH + O2 = 2'-aminobiphenyl-2,3-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63790", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50440", "l": "prostaglandin H1 = prostaglandin D1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004476", "l": "mannose-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005127", "l": "ciliary neurotrophic factor receptor binding", "d": ["Binding to a ciliary neurotrophic factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61444", "l": "a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46051", "l": "D-galactosamine 6-phosphate <=> alpha-D-galactosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8963915", "l": "1,25(OH)2D binds VDR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033509", "l": "USP9X binds Ub:PEX5L (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0120241", "l": "2-iminobutanoate/2-iminopropanoate deaminase", "d": ["Catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17."], "t": []}, {"i": "EC:3.5.99.10", "l": "\"2-iminobutanoate/2-iminopropanoate deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9856465", "l": "MLPH/MYRIP bind GGC-RAB27A and MYO5A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912357", "l": "ITCH ubiquitinates DTX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70819", "l": "L-homoarginine(in) + L-ornithine(out) = L-homoarginine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46819", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64831", "l": "3-hydroxybenzyl alcohol + acetyl-CoA <=> 3-hydroxy-benzyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23888", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine = [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.30", "l": "\"cyanophycin synthase (L-arginine-adding)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030621", "l": "U4 snRNA binding", "d": ["Binding to a U4 small nuclear RNA (U4 snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45447", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62962", "l": "7-dehydrocholesterol(out) => 7-dehydrocholesterol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11162", "l": "L-aspartate 4-semialdehyde + L-glutamate => 2-oxoglutarate + L-2,4-diaminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57784", "l": "1,4-dinitrobenzene + NADH + O2 = 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50200", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102162", "l": "all-trans-8'-apo-beta-carotenal 15,15'-oxygenase activity", "d": ["Catalysis of the reaction: 8'-apo-beta,psi-caroten-8'-al + O2 = all-trans-retinal + 2,6-dimethylocta-2,4,6-trienedial."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54864", "l": "H(+) + NADPH + O2 + sulcatone = 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31896", "l": "(2E,6E)-farnesyl diphosphate => alpha-humulene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669158", "l": "NF2 binds PAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848774", "l": "PTK6 binds DOK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39334", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH <=> (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44706", "l": "a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58713", "l": "NADH + O2 + rifampicin => H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428127", "l": "SPTLC complexes transfer acyl-CoA onto serine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5635854", "l": "GLI2,3 are degraded by the proteasome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38854", "l": "H(+) + tetracenomycin F2 <=> H2O + tetracenomycin F1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78981", "l": "bonnadiene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34435", "l": "4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine = 4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.261", "l": "\"4-dimethylallyltryptophan N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45984", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 = 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29347", "l": "2 H(+)(in) + orotate(in) = 2 H(+)(out) + orotate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848726", "l": "PTK6 phosphorylates BCAR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73171", "l": "adenosine 3',5'-bisphosphate(out) + NAD(+)(in) = adenosine 3',5'-bisphosphate(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-727819", "l": "TAK1 phosphorylates MKK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11774", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH => 6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61668", "l": "ATP + CoA + salicylate = 2-hydroxybenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.65", "l": "\"salicylate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210430", "l": "Release of L-Glutamate at the synapse (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18139", "l": "5alpha-pregnane-3,20-dione + H(+) + NADPH => 3beta-hydroxy-5alpha-pregnane-20-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60924", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + L-lysyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61156", "l": "3'-dephospho-CoA + GTP = CoA + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.237", "l": "\"GTP-dependent dephospho-CoA kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3221982", "l": "BANP binds TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41275", "l": "H2O + N-eicosanoyl-sphing-4-enine = eicosanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102458", "l": "cyanidin 3-O-glucoside 5-O glucosyltransferase (vanilloyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose = cyanin betaine + vanillate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44455", "l": "3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42170", "l": "5beta-pregnan-3,20-dione + H(+) + NADPH => 20alpha-hydroxy-5beta-pregnan-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62052", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.969396173389654", "identifiers": [{"i": "GO:0001664", "l": "G protein-coupled receptor binding", "d": ["Binding to a G protein-coupled receptor."], "t": []}, {"i": "REACT:R-HSA-500717", "l": "Activation of GRIK3 homomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102556", "l": "dammarenediol 12-hydroxylase activity", "d": ["Catalysis of the reaction: dammarenediol-II + NADPH + H+ + O2 = (20S)-protopanaxadiol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981832", "l": "NMUR2 binds neuromedin-S (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51179", "l": "cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35581", "l": "anthocyanin A11 + D-glucose => 1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.8.-", "l": "\"With a flavin as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839376", "l": "TGFBR3(784-851) degradation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59185", "l": "2,4-diacetylphloroglucinol + H2O => 2-acetylphloroglucinol + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15395", "l": "meso-2,6-diaminoheptanedioate => (2S,6S)-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627350", "l": "SMAC (DIABLO) binds XIAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201443", "l": "Type II receptor phosphorylates type I receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43590", "l": "a globoside NOR2 + H(+) + UDP => a globoside NORint + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48890", "l": "(13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O => (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66081", "l": "2-oxopentanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17107", "l": "malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine => malonyl-[ACP] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71055", "l": "L-cysteine(out) + L-methionine(in) = L-cysteine(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70481", "l": "TPI1 isomerizes GA3P to DHAP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450187", "l": "TAK1 is activated within the TAK1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29842", "l": "L-idonate + NADP(+) <=> 2-dehydro-L-idonate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677051", "l": "Formation of the PCAF-ATAC complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804762", "l": "TP53 forms homotetramers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769141", "l": "NPAS4 translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68584", "l": "ATP + H2O + L-tryptophan(out) = ADP + H(+) + L-tryptophan(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072585", "l": "xanthosine nucleotidase activity", "d": ["Catalysis of the reaction: xanthosine + H2O = D-ribose + xanthine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69872", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18502", "l": "ergosterol + NADP(+) => ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57037", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose => (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654409", "l": "Activated FGFR3 binds FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46262", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44516", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68960", "l": "DNA polymerase epsilon binds at the origin (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15258", "l": "D-threonine => acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26446", "l": "3-oxopropanoate + CoA + NADP(+) = H(+) + malonyl-CoA + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.75", "l": "\"malonyl CoA reductase (malonate semialdehyde-forming)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374664", "l": "Phosphorylation and activation of Ezrin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21455", "l": "a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 <=> a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39994", "l": "(4R)-hydroxyeicosasphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-4-hydroxyeicosasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.43", "l": "\"arogenate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39878", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a 2,3-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168046", "l": "Collagen type XII degradation by MMP12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798257", "l": "PTPRS binds NTRK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68852", "l": "(2E,6E)-farnesyl diphosphate + H2O = (1S,6S,7R)-sesquipiperitol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9713785", "l": "Anti-cancer drugs generate DNA interstrand crosslinks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22628", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.6", "l": "\"phosphoribosylaminoimidazolesuccinocarboxamide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77558", "l": "a 3-acyl-sn-glycerol + an acyl-CoA <=> a 1,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78064", "l": "a triacylglycerol + all-trans-retinol => a 1,2-diacylglycerol + an all-trans-retinyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62001", "l": "3 A + protoporphyrinogen IX => 3 AH2 + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247511", "l": "STAB2:ligand is endocytosed (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21134", "l": "H2O2 + urate => H2O + O2 + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018794", "l": "RHOV binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2160874", "l": "HYAL1 hydrolyses (HA)50 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694492", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20433", "l": "NAD(+) + xylitol = D-xylulose + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.9", "l": "\"D-xylulose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78276", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => delta-araneosene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22748", "l": "4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62718", "l": "stemphyloxin II => stemphyloxin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18609", "l": "carbamoyl phosphate + N(2)-acetyl-L-ornithine = H(+) + N(2)-acetyl-L-citrulline + phosphate", "d": [], "t": []}, {"i": "EC:2.1.3.9", "l": "\"N-acetylornithine carbamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18171", "l": "glyoxylate + pyruvate => 4-hydroxy-2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209049", "l": "Phosphorylation of AXN and APC by SGG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632649", "l": "Hh-Npp binds GAS1 and PTCH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49884", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77015", "l": "(S)-leucinol + H2O + NAD(+) = 1-hydroxy-4-methylpentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061483", "l": "sulfinylpropanyl adenylate synthase", "d": ["Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57699", "l": "ATP + cob(I)inamide-[corrinoid adenosyltransferase] <=> adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246514", "l": "botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857686", "l": "FITM1, FITM2 bind TAGs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39271", "l": "(3R)-hydroxy-(15Z)-tetracosenoyl-CoA = (2E,15Z)-tetracosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55136", "l": "ATP + D-alanine + H(+) = D-alanyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389348", "l": "Activation of Rac1 by pVav1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2106625", "l": "Duplex siRNA is loaded into Argonaute (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77162", "l": "H2O + selenophosphate + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N-acetyl-1-seleno-beta-D-glucosamine + phosphate + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30964", "l": "7,9,9'-tri-cis-neurosporene + a quinone => 7,7',9,9'-tetra-cis-lycopene + a quinol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43727", "l": "(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35970", "l": "fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250220", "l": "Homodimerization of ERBB4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24072", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17799", "l": "[(1->4)-beta-D-glucosyl](n+1) + GDP + H(+) => [(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70746", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17129", "l": "ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate", "d": [], "t": []}, {"i": "EC:6.3.5.3", "l": "\"phosphoribosylformylglycinamidine synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76466", "l": "CYP4A11 12-hydroxylates DDCX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10271", "l": "2-dehydro-3-deoxy-D-glucarate <=> 2-hydroxy-3-oxopropanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944223", "l": "Association of procollagen type V (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53571", "l": "12,13-epoxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-12,13-epoxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37848", "l": "13-dihydrodaunorubicin + H(+) + NADPH + O2 => daunorubicin + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632652", "l": "Hh-Npp binds CDON and PTCH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24608", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO2 + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.41", "l": "\"5-dehydro-4-deoxyglucarate dehydratase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73807", "l": "GDP + S-adenosyl-L-methionine = N(7)-methyl-GDP + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50081", "l": "ATP + H2O + taurodeoxycholate(in) => ADP + H(+) + phosphate + taurodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60758", "l": "cinerin I + CoA => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51877", "l": "2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate => desmethylxanthohumol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75675", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate = (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682863", "l": "RNF168 binds DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66350", "l": "(2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + AH2 => 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78483", "l": "2-amino-4-phosphonobutanoate + CTP = CMP-5'-(3-amino-3-carboxypropyl)phosphonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022405", "l": "ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17301", "l": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": [], "t": []}, {"i": "EC:2.7.11.4", "l": "\"[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032216", "l": "glucosaminyl-phosphatidylinositol O-acyltransferase activity", "d": ["Catalysis of the reaction: glucosaminyl-phosphatidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phasphotidylinositol + CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69974", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031830", "l": "type 5A serotonin receptor binding", "d": ["Binding to a type 5A serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804527", "l": "INTL1 binds bacterial glycans (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26082", "l": "(2E,6E)-farnesyl diphosphate => (Z)-gamma-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20937", "l": "2,3-dihydroxy-3-methylbutanoate => 3-methyl-2-oxobutanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55367", "l": "(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 6 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098699", "l": "structural constituent of presynaptic actin cytoskeleton", "d": ["The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53893", "l": "an S-prenyl-L-cysteine + H2O + O2 => a prenal + H2O2 + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47424", "l": "(2E,9Z)-octadecadienoyl-CoA + H2O = (3S)-hydroxy-(9Z-octadecenoyl)-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41965", "l": "butanoyl-CoA + O2 => (2E)-butenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12997", "l": "(E)-feruloyl-CoA + galactarate = 2-O-[(E)-feruloyl]-D-galactarate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.130", "l": "\"galactarate O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.109", "l": "\"matriptase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43843", "l": "26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24269", "l": "2,6-dioxo-6-phenylhexanoate + NADP(+) => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.349", "l": "\"toxoflavin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645535", "l": "ALPK1 phosphorylates TIFA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53695", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O <=> H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.-", "l": "\"In C-halide compounds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201637", "l": "Caspase-mediated cleavage of plectin-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48020", "l": "a globoside Gb3Cer + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70734", "l": "4-aminobutanoate(out) + chloride(out) + 3 Na(+)(out) <=> 4-aminobutanoate(in) + chloride(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42959", "l": "cytidine(38) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36846", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69679", "l": "apigenin 7-O-beta-D-glucoside + H2O = apigenin + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12724", "l": "putrescine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + S-methyl-5'-thioadenosine + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68527", "l": "(2Z,6Z)-farnesyl diphosphate <=> beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30409", "l": "oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin] => hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45247", "l": "(3E,5Z)-octadienoyl-CoA <=> (2E,4E)-octadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30619", "l": "2 A + all-trans-zeta-carotene = 2 AH2 + all-trans-lycopene", "d": [], "t": []}, {"i": "EC:1.3.99.26", "l": "\"all-trans-zeta-carotene desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46050", "l": "alpha-D-galactosamine 1-phosphate => D-galactosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013158", "l": "CDC42 GDIs block activation of CDC42 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73932", "l": "Resynthesis of excised residue by POLB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15762", "l": "L-homoserine + NADP(+) => H(+) + L-aspartate 4-semialdehyde + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186786", "l": "Autophosphorylation of PDGF beta receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69484", "l": "dodecan-1-ol + O2 = dodecanal + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38489", "l": "(9Z)-octadecenoate + glycerol + H(+) => 1-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56049", "l": "daidzein + UDP-alpha-D-glucose => daidzein 7-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67871", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] <=> 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39311", "l": "(8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72722", "l": "eIF2 activation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37607", "l": "(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55853", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-164840", "l": "ADP and Pi bind to ATPase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73513", "l": "CO2 + formaldehyde + pilosin + succinate => 2-oxoglutarate + 8-hydroxysalvigenin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73555", "l": "(E,E)-feruperate + O2 + reduced [NADPH--hemoprotein reductase] = (E,E)-piperate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950128", "l": "Interleukin-12 dissociates from Interleukin-12 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814683", "l": "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58270", "l": "[protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide => [protein]-C-terminal glycine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60772", "l": "2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 = 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54197", "l": "N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9825788", "l": "p-S207 KARS displaces HINT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28942", "l": "H(+)(in) + xanthosine(in) <=> H(+)(out) + xanthosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63919", "l": "5-fluorouridine + ATP <=> 5-fluorouridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56974", "l": "(R)-2-methyl-3-oxopropanoate + H(+) + NADH => (R)-3-hydroxy-2-methylpropanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009671", "l": "nitrate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37529", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202459", "l": "Phosphorylation of Bcl10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008142", "l": "oxysterol binding", "d": ["Binding to oxysterol, an oxidized form of cholesterol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015445", "l": "P-type silver transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ag+(in) = ADP + phosphate + Ag+(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333671", "l": "CLCAs self cleave (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16832", "l": "an aldehyde + H2O + O2 <=> a carboxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033994", "l": "glucuronan lyase activity", "d": ["Catalysis of the reaction: (1->4)-beta-D-glucuronan = an oligosaccharide with 4-deoxy-beta-D-gluc-4-enuronosyl end + (1->4)-beta-D-glucuronan. This reaction is the eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5195402", "l": "CDK1 phosphorylates LPIN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052625", "l": "4-aminobenzoate amino acid synthetase activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + ATP + amino acid = 4-aminobenzoyl amino acid conjugate + AMP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950740", "l": "CANX dissociates from IL12A:EBI3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18041", "l": "2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] = 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.7.7.1", "l": "\"ferredoxin--nitrite reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69290", "l": "sulfate + sulforaphane => (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032564", "l": "dATP binding", "d": ["Binding to dATP, deoxyadenosine triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626227", "l": "CP110 and CEP97 dissociate from the centriole (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332356", "l": "CAMK2 binds MAP3K7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63169", "l": "fumarate + L-cysteine => S-(2-succino)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9858647", "l": "HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061752", "l": "telomeric repeat-containing RNA binding", "d": ["Binding to long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71498", "l": "6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in) <=> 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22363", "l": "D-glutamate <=> 5-oxo-D-proline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10566", "l": "H(+) + methanol + oxaloacetate => H2O + oxaloacetate 4-methyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39631", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH = (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42551", "l": "uridine(746) in 23S rRNA <=> pseudouridine(746) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0051015", "l": "actin filament binding", "d": ["Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17132", "l": "ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63361", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 => (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72820", "l": "L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) => L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34066", "l": "2-deoxystreptamine + UDP-alpha-D-glucose <=> 2'-deamino-2'-hydroxyparomamine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840429", "l": "DELE1(143-515) binds EIF2AK1 (HRI) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983422", "l": "Disassembly of COPII coated vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193668", "l": "p75NTR and RHOA-GDI interact (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70979", "l": "MDH2 dimer dehydrogenates MAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47862", "l": "a ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate => a ganglioside GT1b (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.5.1", "l": "\"sesamin methylene transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34118", "l": "carboxynorspermidine + H2O + NADP(+) <=> H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53248", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855164", "l": "IP6 transports from the cytosol to the ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70428", "l": "H2O + phenylacetyl-CoA => 2-phenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47033", "l": "AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA => 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34819", "l": "dihydrocurcumin + NADP(+) = curcumin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003693", "l": "P-element binding", "d": ["Binding to a P-element, a class of Drosophila transposon responsible for hybrid dysgenesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374662", "l": "Translocation of Ezrin to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2981040", "l": "COLEC12:ligand is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15971", "l": "glutathione disulfide + H2O + methylarsonous acid => 2 glutathione + H(+) + methylarsonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9835358", "l": "p-TARBP2 binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43132", "l": "N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-methionine = H(+) + N(2)-dimethylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73843", "l": "a 27-hydroxysterol + UDP-alpha-D-glucose = a sterol 27-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.9.-", "l": "\"Phosphotransferases with paired acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047250", "l": "4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + UDP-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32529", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate + N-acetyl-D-glucosamine => N,N'-diacetylchitobiose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.318", "l": "\"eugenol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58657", "l": "a 5'-end 5'-phospho-ribonucleoside-RNA + S-adenosyl-L-methionine => a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874079", "l": "PTK2 binds activated MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050260", "l": "ribose-5-phosphate-ammonia ligase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + ATP + NH4 = 5-phospho-D-ribosylamine + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10595", "l": "a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021334", "l": "STAT1 binds HEY1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45555", "l": "H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57807", "l": "1-chloro-3-nitrobenzene + NADH + O2 <=> 4-chlorocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61965", "l": "a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60103", "l": "cyanidin + UDP-alpha-D-glucose <=> cyanidin 3-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730836", "l": "Interaction of BCL10:MALT1 with CARMA1 to form CBM complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58902", "l": "NH4(+) + urea-1,3-dicarboxylate => 1-carboxybiuret + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481007", "l": "Exocytosis of platelet alpha granule contents (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1015699", "l": "ISGF3 binds the ISRE promoter elements in IFN-stimulated genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10145", "l": "a ribonucleoside 3'-phosphate + H2O => a ribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33470", "l": "5-dehydroepisterol + H(+) + NADPH + O2 <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67666", "l": "1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid => [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.108", "l": "\"nocturnin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51385", "l": "hexadecanoyl-CoA + serotonin => CoA + H(+) + N-hexadecanoyl-serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39899", "l": "7-deoxyloganetin + UDP-alpha-D-glucose = 7-deoxyloganin + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.324", "l": "\"7-deoxyloganetin glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30413", "l": "benzyl benzoate + CoA => benzoyl-CoA + benzyl alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25568", "l": "ATP + beta-D-ribosylnicotinate = ADP + H(+) + nicotinate beta-D-ribonucleotide", "d": [], "t": []}, {"i": "EC:2.7.1.173", "l": "\"nicotinate riboside kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49893", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 => (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202969", "l": "Caspase mediated cleavage of beta-catenin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170978", "l": "p-FRS2:CRKL binds C3G (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71328", "l": "chloride(out) + L-threonine(out) + 2 Na(+)(out) => chloride(in) + L-threonine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68235", "l": "L-cysteine(in) + Na(+)(in) <=> L-cysteine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042349", "l": "guiding stereospecific synthesis activity", "d": ["The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9794523", "l": "SLC22A1 transports Cipro into renal cell (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11373", "l": "ATP + L-aspartate + NH4(+) => AMP + diphosphate + H(+) + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592371", "l": "Initial activation of proMMP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1467466", "l": "ABCA4 mediates atRAL transport (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67445", "l": "an (R)-2-hydroxy-long-chain-fatty acyl-CoA => a long-chain fatty aldehyde + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32333", "l": "(1S,4R)-fenchone + H(+) + NADH => (1S,2S,4R)-endo-fenchol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0003823", "l": "antigen binding", "d": ["Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. Antigen binding by an MHC protein complex allows the antigen to be displayed to a T cell or NK cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380949", "l": "AMPK is dephosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70096", "l": "(R)-5-methyl-tetronate + o-quinone methide => peniphenone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49547", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O <=> 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685605", "l": "SLAMF7 binds SLAMF7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26017", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate <=> 3-dehydroquinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63081", "l": "AH2 + ATP + ilicicolinate B => A + AMP + diphosphate + ilicicolin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928619", "l": "PAK1 binds RAC1:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666008", "l": "SCAI binds SRF:MKL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54969", "l": "hexadecanoyl phosphate + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022453", "l": "MECP2 binds 5hmC-DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194818", "l": "botA LC cleaves target cell SNAP25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71355", "l": "5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) = 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030759", "l": "methylquercetagetin 6-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130725", "l": "Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162253", "l": "PDSS1,2 ligates FPP to IPPP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16889", "l": "2-oxoglutarate + 6-acetamido-3-aminohexanoate = 6-acetamido-3-oxohexanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.65", "l": "\"N(6)-acetyl-beta-lysine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712087", "l": "ALK fusions phosphorylate FRS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437230", "l": "L1-FGFR cis-heterodimerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31985", "l": "abieta-7,13-dien-18,18-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655828", "l": "Expression of Lanosterol Synthase (LSS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34554", "l": "ATP + cob(II)yrinate c monoamide + H2O + L-glutamine <=> ADP + cob(II)yrinate a,c diamide + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74406", "l": "2 (S)-lactate(in) + prostaglandin D2(out) <=> 2 (S)-lactate(out) + prostaglandin D2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30410", "l": "hnu + oxidized [2Fe-2S]-[ferredoxin] + reduced [plastocyanin] <=> oxidized [plastocyanin] + reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33032", "l": "H(+) + keto-D-fructose + NADH => D-sorbitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694409", "l": "Nucleotide exchange on RAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201717", "l": "CSNK2-mediated phosphorylation of DVL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16583", "l": "2 Fe(III)-[cytochrome c] + 2 H2O => 2 Fe(II)-[cytochrome c] + 2 H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73314", "l": "L-thyroxine sulfate(out) <=> L-thyroxine sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40745", "l": "(20S)-ginsenoside C-K + 2 D-glucose => (20S)-ginsenoside Rd + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.108", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41314", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651828", "l": "PARG dePARylates PARP1,PARP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21256", "l": "3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.19", "l": "\"3-phosphoshikimate 1-carboxyvinyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051269", "l": "alpha-keto ester reductase activity", "d": ["Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.13", "l": "\"clostridial aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368582", "l": "CXXC4 binds DVL to prevent AXIN binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29062", "l": "2 H(+)(in) + H2 + ubiquinone-8 <=> 2 H(+)(out) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31039", "l": "dodecanoyl-CoA + FAD + H(+) = (2E)-dodecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.137", "l": "\"mannan exo-1,2-1,6-alpha-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389976", "l": "Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607734", "l": "PKC-delta translocates to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839073", "l": "HTRA2 binds NDUFA13 (GRIM-19) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64225", "l": "AH2 + O2 + uridine(34) in tRNA => 5-hydroxyuridine(34) in tRNA + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25588", "l": "D-threo-isocitrate + NADP(+) = (S)-oxalosuccinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33630", "l": "ATP + CoA + decanoate <=> AMP + decanoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20412", "l": "alpha-D-glucose 1-phosphate + riboflavin <=> D-glucose + FMN", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71119", "l": "H(+) + hispidin + NADPH + O2 = 3-hydroxyhispidin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.1", "l": "\"acylaminoacyl-peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350403", "l": "DGO binds to PK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74718", "l": "Internalisation of the insulin receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18417", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM3 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.3.9", "l": "\"lactosylceramide alpha-2,3-sialyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.012360833342299", "identifiers": [{"i": "GO:0000977", "l": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "d": ["Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788999", "l": "HV1-mediated H+ transfer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797090", "l": "CCNK binds CDK12 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045303", "l": "diaminobutyrate-2-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76031", "l": "2 H2O2 => O2 + 2 H2O (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18051", "l": "L-glutamate + N-acetyl-L-glutamate 5-semialdehyde => 2-oxoglutarate + N(2)-acetyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917696", "l": "Cargo Sequestration (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33701", "l": "(4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O => C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40279", "l": "(R)-carnitine + dodecanoyl-CoA = CoA + O-dodecanoyl-R-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33302", "l": "[eIF5A protein]-L-lysine + spermidine <=> [eIF5A protein]-deoxyhypusine + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106155", "l": "peptidyl-lysine 3-dioxygenase activity", "d": ["Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 3-hydroxy-L-lysine + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18977", "l": "a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71171", "l": "H(+)(in) + L-cysteine(out) + Na(+)(out) = H(+)(out) + L-cysteine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160081", "l": "iodide channel activity", "d": ["Enables the energy-independent facilitated diffusion of iodide through a transmembrane aqueous pore or channel."], "t": []}, {"i": "RHEA:66324", "l": "iodide(out) = iodide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847977", "l": "FRK phosphorylates PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17527", "l": "NH4(+) + urea-1-carboxylate => biuret + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45475", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24992", "l": "L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070892", "l": "lipoteichoic acid immune receptor activity", "d": ["Combining with lipoteichoic acid and transmitting the signal to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934465", "l": "SHC1 binds PTPN12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58754", "l": "1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848776", "l": "PTK6 phosphorylates DOK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68520", "l": "(2E,6E)-farnesyl diphosphate = beta-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.106", "l": "\"fatty acid photodecarboxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4837364", "l": "Secretion of SOD3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72522", "l": "2 H(+) + NADH + O2 + phenazine-1,6-dicarboxylate <=> 6-hydroxyphenazine-1-carboxylate + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160016", "l": "CCACCA tRNA nucleotidyltransferase activity", "d": ["Catalysis of the reaction: an unstable tRNA + 2 ATP + 4 CTP = a tRNA with a 3' CCACCA end + 6 diphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417890", "l": "P2Y5 receptor can bind to LPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017441", "l": "PPARG gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71236", "l": "[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] => [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14052", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624494", "l": "RAF1 binds p21 RAS:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046180", "l": "KSPG is secreted from the cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77133", "l": "1D-myo-inositol 1,2-bisphosphate + phosphate => 1D-myo-inositol 1,2,6-trisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36645", "l": "H(+) + questin + S-adenosyl-L-homocysteine => emodin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18177", "l": "a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.44", "l": "\"trans-2-enoyl-CoA reductase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983156", "l": "Polyubiquitination of substrate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170149", "l": "Translocation of active Cdc25C to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65357", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66439", "l": "NADP(+) + pentan-3-one <=> H(+) + NADPH + pent-1-en-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44042", "l": "14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate => 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21768", "l": "H2O + N-methyl-L-alanine + NADP(+) = H(+) + methylamine + NADPH + pyruvate", "d": [], "t": []}, {"i": "EC:1.4.1.17", "l": "\"N-methylalanine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52926", "l": "16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674140", "l": "PAQR3 binds inactive RAFs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36130", "l": "gibberellin A34 + S-adenosyl-L-methionine <=> O-methyl gibberellin A34 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50764", "l": "4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = 4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62125", "l": "a 2'-deoxyribonucleoside 5'-phosphate + GTP => a 2'-deoxyribonucleoside 5'-diphosphate + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445072", "l": "Interaction of PAK1 with Rac1-GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18575", "l": "chelirubine + H2O2 => dihydrochelirubine + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805061", "l": "CK2 binds FACT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49443", "l": "(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA <=> (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782138", "l": "ERCC5 and RPA bind TC-NER site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18782", "l": "H(+) + malonyl-CoA => acetyl-CoA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48709", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => a fatty acid + H(+) + long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29703", "l": "L-valine(in) = L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14334", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol => 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-997381", "l": "TDPK phosphorylates ThDP to ThTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29136", "l": "a menaquinol + 2 H(+)(in) + nitrate => a menaquinone + 2 H(+)(out) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69801", "l": "D-tryptophan + tRNA(Trp) => D-tryptophanyl-tRNA(Trp) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001165", "l": "RNA polymerase I cis-regulatory region sequence-specific DNA binding", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102303", "l": "resveratrol 3,5-O-dimethyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + trans-resveratrol = 2 S-adenosyl-L-homocysteine + pterostilbene + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944227", "l": "Association of procollagen type XXII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66983", "l": "2-methylbutanoyl-CoA + H2O <=> 2-methylbutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23337", "l": "2 H(+) + H2O2 + 2 iodide => diiodine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74795", "l": "N-methyl-(R)-salsolinol(in) = N-methyl-(R)-salsolinol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41968", "l": "a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73577", "l": "CAD hexamer transforms L-Gln to CAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.784091957229677", "identifiers": [{"i": "GO:0097747", "l": "RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57764", "l": "2,6-dinitrotoluene + NADH + O2 = 3-methyl-4-nitrocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49172", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine = 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55499", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44066", "l": "CoA + octyl hexadecanoyl => hexadecanoyl-CoA + octan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40388", "l": "1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP => 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419166", "l": "GEFs activate RhoA,B,C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944454", "l": "mTORC1 phosphorylates MAF1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71173", "l": "GSTZ1 isomerizes 4-MAA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60479", "l": "2 ATP + GTP <=> 3',3',3'-cAAG + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61863", "l": "dehydroprobetaenone I + H(+) + NADPH + O2 <=> epoxybetaenone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172126", "l": "DAP12 interacts with NKG2C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72103", "l": "Formation of pre-mRNPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428990", "l": "Arachidonate diffuses across the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51245", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176318", "l": "Loading of claspin onto DNA during replication origin firing (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672973", "l": "MAP2Ks phosphorylate MAPKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17346", "l": "(S)-methylmalonyl-CoA + H2O => CoA + H(+) + methylmalonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66269", "l": "CoA + nonanoyl-AMP => AMP + H(+) + nonanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839065", "l": "Phosphorylation of cytosolic FGFR1 fusion dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177942", "l": "EGFR binds EGF ligand (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6796649", "l": "TP53 binds the CCNK gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390595", "l": "Calcium Binds Troponin-C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46120", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64002", "l": "CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69147", "l": "agmatine + H2O + O2 <=> 4-guanidinobutanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0031717", "l": "cannabinoid receptor binding", "d": ["Binding to a cannabinoid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29402", "l": "H2O + ITP <=> diphosphate + H(+) + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0016597", "l": "amino acid binding", "d": ["Binding to an amino acid, organic acids containing one or more amino substituents."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008882", "l": "[glutamate-ammonia-ligase] adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162657", "l": "Inactivation of Myt1 kinase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63592", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9708275", "l": "PDE4A binds PDE4A inhibitors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67379", "l": "glycyl-L-histidine + H2O <=> glycine + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59142", "l": "AMP + diphosphate + H(+) + staphyloferrin A => ATP + citrate + N(5)-[(S)-citryl]-D-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47425", "l": "(2E,9Z)-octadecadienoyl-CoA + H2O => (3S)-hydroxy-(9Z-octadecenoyl)-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24735", "l": "2-oxoglutarate + 4-hydroxybutanoate => (R)-2-hydroxyglutarate + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23141", "l": "beta-nicotinamide D-ribonucleotide + H2O => D-ribose 5-phosphate + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58335", "l": "(E)-non-2-en-1-ol + NADP(+) <=> (E)-non-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21513", "l": "3,6-anhydro-L-galactonate => 2-dehydro-3-deoxy-L-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11100", "l": "4-hydroxyhexan-3-one = 2 propanal", "d": [], "t": []}, {"i": "EC:4.1.2.35", "l": "\"propioin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170001", "l": "ergothioneine transmembrane transporter activity", "d": ["Enables the transfer of ergothioneine from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.162", "l": "\"N-acetylhexosamine 1-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009309", "l": "RUNX2 binds STUB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37594", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49596", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose = H(+) + N-acyl-D-galactosylsphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11750", "l": "4-fluoro-L-threonine + acetaldehyde => fluoroacetaldehyde + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56928", "l": "abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699163", "l": "Defective BARD1 does not bind BRCA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44187", "l": "D-sedoheptulose 7-phosphate <=> 2-epi-5-epi-valiolone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74591", "l": "(+)-exo-beta-bergamotene + 3 O2 + 2 reduced [NADPH--hemoprotein reductase] = 5-dehydro-6-demethoxyfumagillol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.184", "l": "\"5-dehydro-6-demethoxyfumagillol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19466", "l": "NADPH + 2 nitric oxide + 2 O2 => H(+) + NADP(+) + 2 nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.39", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10668", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)", "d": [], "t": []}, {"i": "EC:2.3.2.3", "l": "\"lysyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390597", "l": "Release Of ADP From Myosin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51303", "l": "(9Z)-octadecenoate + L-phenylalanine <=> H2O + N-(9Z-octadecenoyl)-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983307", "l": "IL15 binds IL15RA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63874", "l": "3(1)-hydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + L-isoleucine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12379", "l": "ATP + L-fuculose <=> ADP + H(+) + L-fuculose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432909", "l": "Interaction of Plectin with Integrin beta 4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45453", "l": "H2O + N-tetradecanoylethanolamine => ethanolamine + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62611", "l": "glutathione + H(+) + hydrogen sulfide + ubiquinone-10 <=> S-sulfanylglutathione + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003941", "l": "L-serine ammonia-lyase activity", "d": ["Catalysis of the reaction: L-serine = pyruvate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12010", "l": "[G-protein-coupled receptor]-phosphate + ADP + H(+) => [G-protein-coupled receptor] + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.-", "l": "\"Aldehyde-lyases\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010521", "l": "telomerase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of telomerase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58110", "l": "acetate + L-lysyl-[protein] => H2O + N(6)-acetyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976810", "l": "Complement factor I binds to extracellular Factor H:C3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050386", "l": "ureidosuccinase activity", "d": ["Catalysis of the reaction: N-carbamoyl-L-aspartate + H2O + 2 H+ = L-aspartate + CO2 + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45172", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031865", "l": "EP2 subtype prostaglandin E2 receptor binding", "d": ["Binding to an EP2 subtype prostaglandin E2 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373711", "l": "DCC interaction with Netrin-1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9866253", "l": "apo-UQCRFS1 binds LYRM7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69561", "l": "D-mannose(out) + H(+)(out) => D-mannose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209891", "l": "Dopamine is oxidised to noradrenaline (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60856", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19809", "l": "(S)-ureidoglycolate + 2 H(+) + H2O = CO2 + glyoxylate + 2 NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.116", "l": "\"ureidoglycolate amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50288", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35228", "l": "H(+)(out) + rifampicin(in) => H(+)(in) + rifampicin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72542", "l": "3,4-dihydroxybenzaldehyde + H2O + NADP(+) <=> 3,4-dihydroxybenzoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46416", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.26", "l": "\"acyl-[acyl-carrier-protein] 6-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804100", "l": "HMGB1 binds LPS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31705", "l": "H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol => 2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3782655", "l": "HDAC10 deacetylates histone (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73289", "l": "(2S)-naringenin 4'-methyl ether + H(+) + S-adenosyl-L-homocysteine => (2S)-naringenin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805811", "l": "Release of SEPT4 from mitochondria (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665871", "l": "ADRM1 binds 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50305", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39951", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60374", "l": "D-fructose(in) => D-fructose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009485", "l": "IL34:CSF1 binds CSF1R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390593", "l": "ATP Hydrolysis By Myosin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840564", "l": "OMA1 hydrolyzes YME1L1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53484", "l": "androst-4-ene-3,11,17-trione + H(+) + NADPH = 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27984", "l": "7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate => 7-carboxy-7-deazaguanine + ATP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013159", "l": "CDC42 GEFs activate CDC42 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029460", "l": "PAK1 phosphorylates LIMK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73932", "l": "Resynthesis of excised residue by POLB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55476", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57046", "l": "3-oxoisoapionate + H(+) + NADH => D-apionate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784861", "l": "HSPG binds LPL dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36598", "l": "hydrogen sulfide + NADP(+) <=> NADPH + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68611", "l": "Formation of ORC(1-5) complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168909", "l": "viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66664", "l": "ATP + coproporphyrin III(in) + H2O = ADP + coproporphyrin III(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63536", "l": "bradykinin(1-8) + H2O = bradykinin(1-7) + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77269", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034942", "l": "cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity", "d": ["Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = cis-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426150", "l": "SREBP1A,1C,2 binds the HMGCS1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32409", "l": "(1R,4S)-isodihydrocarvone + H(+) + NADH => (1R,2S,4S)-neoisodihydrocarveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20506", "l": "an alpha-(gamma-L-glutamyl)-L-amino acid => 5-oxo-L-proline + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734713", "l": "ORC6 translocates to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30779", "l": "D-gluconate + FAD + H(+) = 2-dehydro-D-gluconate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690152", "l": "USP5 cleaves polyubiquitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77354", "l": "2-oxobutanoate + N(omega),N(omega)-dimethyl-L-arginine <=> (2S)-2-aminobutanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25257", "l": "N-acetyl-D-glucosamine 6-phosphate = N-acetyl-D-mannosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71748", "l": "2-oxoglutarate(out) + L-2-aminoadipate(in) => 2-oxoglutarate(in) + L-2-aminoadipate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160090", "l": "internal mRNA (guanine-N7-)-methyltransferase activity", "d": ["Catalysis of the reaction: a guanosine in mRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39725", "l": "a 1,2-diacyl-sn-glycerol(out) => a 1,2-diacyl-sn-glycerol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0033038", "l": "bitter taste receptor activity", "d": ["Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210285", "l": "Trans-homophilic interaction of PECAM-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49159", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine <=> dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69816", "l": "cathasterone + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942052", "l": "Superoxide and nitric oxide react to peroxynitrite in the phagosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018496", "l": "2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433418", "l": "Phosphorylation of JAK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40510", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71329", "l": "chloride(in) + L-threonine(in) + 2 Na(+)(in) => chloride(out) + L-threonine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47587", "l": "a ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose <=> a ganglioside GT1c (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14934", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76349", "l": "(2R,3S)-3-isopropylmalate(out) + sulfate(in) => (2R,3S)-3-isopropylmalate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10213", "l": "2-oxoglutarate + 5-aminopentanoate => 5-oxopentanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16951", "l": "H(+) + NADH + scyllo-inosose => myo-inositol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21846", "l": "CoA + H(+) + N(2)-phenylacetyl-L-glutamine => L-glutamine + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873926", "l": "IFNG dimer binds IFNGR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49302", "l": "alpha-maltose 6'-phosphate(in) + L-histidyl-[protein] => D-maltose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046428", "l": "1,4-dihydroxy-2-naphthoate octaprenyltransferase activity", "d": ["Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = dimethylmenaquinone + diphosphate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140842", "l": "n fibrin monomers -> fibrin multimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29077", "l": "CO2(out) + H(+)(out) + ubiquinol-8 => formate(out) + 2 H(+)(in) + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806831", "l": "CYB5Rs reduce MetHb to HbA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110218", "l": "Cleavage of uracil by TDG glycosylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877187", "l": "P2X7 mediates loss of intracellular K+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44826", "l": "a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55941", "l": "all-trans-3,4-didehydroretinol + NAD(+) => all-trans-3,4-didehydroretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52072", "l": "12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64184", "l": "H2O + N-(9Z-octadecenoyl)-L-tyrosine = (9Z)-octadecenoate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011241", "l": "SRC phosphorylates ROBO3.1 in response to NTN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20292", "l": "acetyl-CoA + H2O <=> acetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10023", "l": "H2O + L-saccharopine + NADP(+) <=> (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60797", "l": "2 2-oxoglutarate + gibberellin A53 + H(+) + 3 O2 => 3 CO2 + gibberellin A20 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35683", "l": "hexadecasphinganine + NADP(+) = 3-oxohexadecasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617972", "l": "FOXO3 binds SOD2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34785", "l": "a 3-oxosteroid + H(+) + NADPH => a 3alpha-hydroxysteroid + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549129", "l": "OCT1 transports organic cations into hepatic cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047548", "l": "2-methyleneglutarate mutase activity", "d": ["Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938108", "l": "SERPINB13 binds cathepsin L (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982617", "l": "CYGB:O2 dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41062", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA <=> 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168038", "l": "Collagen type XV restin release (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212614", "l": "Glutamine transport from astrocytes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59433", "l": "3-hydroxypropanal + H2O + NAD(+) => 3-hydroxypropanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63490", "l": "NADP(+) + phenanthrene-9,10-diol => 9,10-phenanthroquinone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12695", "l": "3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+) => 3,4-dihydroxypyridine + O-acetyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0004614", "l": "phosphoglucomutase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66641", "l": "(2E,6E)-farnesyl diphosphate + H2O => diphosphate + koraiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68131", "l": "a fatty acyl-CoA + phytol <=> a fatty acid phytyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12821", "l": "2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate", "d": [], "t": []}, {"i": "EC:4.1.2.4", "l": "\"deoxyribose-phosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "58.247646903929386", "identifiers": [{"i": "GO:0016614", "l": "oxidoreductase activity, acting on CH-OH group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2012082", "l": "Autocatalytic phosphorylation of FGFR3 cysteine mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.188221489317044", "identifiers": [{"i": "GO:0101005", "l": "deubiquitinase activity", "d": ["An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated."], "t": []}, {"i": "REACT:R-HSA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67496", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O = 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432148", "l": "Fgr may phosphorylate p38 MAPK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49297", "l": "keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + L-sorbose 1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800298", "l": "HGF dimer binds MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22528", "l": "a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose = a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.159", "l": "\"flavonol-3-O-glucoside L-rhamnosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53589", "l": "NAD(+) + resolvin D2 => 16-oxoresolvin D2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59782", "l": "(2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine => L-histidine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14728", "l": "2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0008516", "l": "hexose uniporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202216", "l": "Phosphorylation of SLP-76 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32755", "l": "(2S)-naringenin + 2-oxoglutarate + O2 = apigenin + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788622", "l": "p-Y-STATs dimerize (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211904", "l": "CYP4F12 18-hydroxylates ARA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71474", "l": "H2O + substance P <=> L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19552", "l": "H2O + o-orsellinate depside <=> H(+) + 2 orsellinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607002", "l": "Activated protein C cleaves factor VIIIa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51063", "l": "5alpha-androst-1-ene-3,17-dione + A <=> AH2 + androsta-1,4-diene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71049", "l": "glycine(out) + L-phenylalanine(in) => glycine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57859", "l": "(E)-feruloyl-CoA + 2-oxoglutarate + O2 <=> (E)-6-hydroxyferuloyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689317", "l": "Formation of the pre-incision complex in GG-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031706", "l": "subtype 3 bombesin receptor binding", "d": ["Binding to a subtype 3 bombesin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73582", "l": "(E,E)-piperoyl-AMP + CoA <=> (E,E)-piperoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005461", "l": "UDP-glucuronic acid transmembrane transporter activity", "d": ["Enables the transfer of a UDP-glucuronic acid from one side of a membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55575", "l": "4-hydoxytryptamine 4-phosphate + S-adenosyl-L-methionine <=> 4-hydroxy-N-methyltryptamine 4-phosphate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54284", "l": "H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-octadecanoylsphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56755", "l": "a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19085", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.33", "l": "\"dTDP-4-amino-4,6-dideoxy-D-glucose transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1253343", "l": "WWOX binds ERBB4s80 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193655", "l": "Myelin components can interact with p75NTR:NgR:LINGO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55895", "l": "a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 <=> a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785607", "l": "FANCM binds FAAP24 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218814", "l": "PAK2 autophorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033709", "l": "D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity", "d": ["Catalysis of the reaction: D-arabinitol + NADP+ = D-ribulose + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19861", "l": "a 16alpha-hydroxysteroid + NAD(+) = a 16-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50870", "l": "(5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193686", "l": "p75NTR interacts with IRAK:MYD88 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58640", "l": "a 5'-end 5'-phospho-ribonucleoside-RNA + 2 S-adenosyl-L-methionine = a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56909", "l": "(7S)-O-acetylsalutaridinol => acetate + H(+) + thebaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388814", "l": "Grb2 binds CD28 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000253", "l": "3-keto sterol reductase activity", "d": ["Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67520", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806831", "l": "CYB5Rs reduce MetHb to HbA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43259", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002950", "l": "ceramide phosphoethanolamine synthase activity", "d": ["Catalysis of the reaction: an N-acyl-sphingoid base + CDP-ethanolamine = an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093327", "l": "EPHA binds TIAM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17097", "l": "3-phenylpyruvate = enol-phenylpyruvate", "d": [], "t": []}, {"i": "EC:5.3.2.1", "l": "\"phenylpyruvate tautomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27916", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate => 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022399", "l": "ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045439", "l": "isopenicillin-N epimerase activity", "d": ["Catalysis of the reaction: isopenicillin N = penicillin N."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23959", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18701", "l": "arsenite + H2O + 2 oxidized [azurin] = arsenate + 3 H(+) + 2 reduced [azurin]", "d": [], "t": []}, {"i": "EC:1.20.9.1", "l": "\"arsenate reductase (azurin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76466", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + A <=> 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421453", "l": "Mitochondrial uptake and processing of ALAS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428749", "l": "Activated TP receptor binds G-proten Gq (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858489", "l": "ppDVL binds DAAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733960", "l": "Bile salts and acids dissociate from ALB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74359", "l": "coproporphyrin I(out) = coproporphyrin I(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004608", "l": "phosphatidylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H+ + phosphatidyl-N-methylethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033039", "l": "ionotropic salty taste receptor activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a soluble salty compound has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018768", "l": "RHOU auto-activates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32428", "l": "(1R,4S)-isodihydrocarvone + A => (S)-carvone + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685953", "l": "SIRT6 deacetylates RBBP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11328", "l": "dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.28", "l": "\"dimethylallylcistransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32776", "l": "(2-aminoethyl)phosphonate(out) + ATP + H2O => (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56826", "l": "A + cyclooctatin + H2O => AH2 + cyclooctat-9-ene-5,7-diol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814675", "l": "RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13866", "l": "GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59583", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester <=> CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64632", "l": "acetyl-CoA + butan-1-ol = butyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25289", "l": "lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37801", "l": "2 H2O + 2 NAD(+) => 2 H(+) + 2 NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43558", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50110", "l": "CoA + H(+) + N-hexadecanoyl-taurine => hexadecanoyl-CoA + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707523", "l": "Hemes bind to BACH1:MAFK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022405", "l": "ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44239", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25560", "l": "9alpha-copalyl diphosphate = 9beta-pimara-7,15-diene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.35", "l": "\"syn-pimara-7,15-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58705", "l": "rifampicin hemiaminal => rifampicin ortho-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19930", "l": "[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->4)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090411", "l": "brassinosteroid binding", "d": ["Binding to a brassinosteroid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36025", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49133", "l": "an adenosine in tRNA + S-adenosyl-L-methionine => an N(1)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671850", "l": "JAK2 Phosphoryates STAT3 in Response to Leptin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852010", "l": "BTNL2 binds activated T cells surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17597", "l": "D-mannitol + 2 Fe(III)-[cytochrome c] = D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.1.2.2", "l": "\"mannitol dehydrogenase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74723", "l": "Endosome acidification (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.111", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050280", "l": "sequoyitol dehydrogenase activity", "d": ["Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + NAD+ = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15400", "l": "dichloromethane + H2O <=> 2 chloride + formaldehyde + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141409", "l": "Mad1 binds kinetochore (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447226", "l": "Interleukin-12 binds Interleukin-12 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419279", "l": "Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251942", "l": "Hikeshi binds HSP70s:ATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201634", "l": "Caspase-mediated cleavage of FADK 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15740", "l": "cyclopentanone + H(+) + NADPH + O2 <=> 5-valerolactone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2173317", "l": "C3a anaphylatoxin binds C3a receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55176", "l": "2-oxoglutarate + butanoyl-CoA + O2 = 2-hydroxybutanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30683", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-D-mannosamine + UDP", "d": [], "t": []}, {"i": "EC:3.2.1.183", "l": "\"UDP-N-acetylglucosamine 2-epimerase (hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632738", "l": "DDIT4 binds 14-3-3 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32580", "l": "(2E)-geranyl diphosphate => (1R,5R)-beta-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196753", "l": "2xPPCS ligates PPanK with Cys (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047991", "l": "hydroxylamine oxidase activity", "d": ["Catalysis of the reaction: hydroxylamine + O2 = H2O + H+ + nitrite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72500", "l": "2-oxoglutarate(in) + prostaglandin E2(out) => 2-oxoglutarate(out) + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53380", "l": "5,6-dihydrouridine(16) in tRNA + NAD(+) = H(+) + NADH + uridine(16) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3364014", "l": "Recruitment of SET1 methyltransferase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448673", "l": "Formation of caspase-1 p10/p20 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37923", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017161", "l": "inositol-1,3,4-trisphosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203977", "l": "SAR1 Activation And Membrane Binding (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57056", "l": "D-apiofuranose + NAD(+) = D-apionolactone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.420", "l": "\"D-apiose dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684140", "l": "ATM phosphorylates RBBP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73997", "l": "(S)-(+)-nephthenol + diphosphate => geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0008553", "l": "P-type proton-exporting transporter activity", "d": ["Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961840", "l": "E2F1 binds the CCNE1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75287", "l": "glyoxylate(in) + sulfate(out) = glyoxylate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78722", "l": "3-dehydro-alpha,alpha-trehalose + H2O <=> 3-dehydro-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.7", "l": "\"ribonuclease P4\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0004471", "l": "malate dehydrogenase (decarboxylating) (NAD+) activity", "d": ["Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39020", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66022", "l": "[collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O => H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77320", "l": "N(omega)-methyl-L-arginine + pyruvate => 5-(3-methylguanidino)-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32979", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O = a fatty acid + H(+) + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22234", "l": "diphosphate + NADP(+) + squalene => H(+) + NADPH + presqualene diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9668831", "l": "CST complex formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20642", "l": "H2O + L-histidinol + 2 NAD(+) => 3 H(+) + L-histidine + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17457", "l": "[sulfur-carrier protein]-L-cysteine + L-cysteine = [sulfur-carrier protein]-S-sulfanyl-L-cysteine + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43385", "l": "ATP + L-arginyl-[protein] => ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110307", "l": "REV1 binds AP-dsDNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52168", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52563", "l": "2-dehydro-D-erythronate <=> 3-dehydro-D-erythronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806610", "l": "Keratin filament formation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031712", "l": "B1 bradykinin receptor binding", "d": ["Binding to a B1 bradykinin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134954", "l": "DHX9 binds DNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38703", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674022", "l": "BRAP autoubiquitinates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730903", "l": "Oligomerization of TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40585", "l": "CoA + H(+) + hexanedioate => H2O + hexanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60854", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603784", "l": "PEX19:class I PMP binds PEX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5623643", "l": "RDH13 reduces atRAL to atROL (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41567", "l": "aklavinone + dTDP-beta-L-rhodosamine <=> aclacinomycin T + dTDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66100", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine = H2O + kynurenate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9733969", "l": "Bile salts dissociate from FABP6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65492", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine", "d": [], "t": []}, {"i": "EC:1.3.98.7", "l": "\"[mycofactocin precursor peptide]-tyrosine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16653", "l": "D-gluconate + NADP(+) = 2-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.215", "l": "\"gluconate 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14918", "l": "3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] => 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62201", "l": "ethanol + 2 Fe(III)-[cytochrome c] => acetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015572", "l": "N-acetylglucosamine transmembrane transporter activity", "d": ["Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796049", "l": "AcK-NFE2L2 binds the SOD3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52112", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12429", "l": "2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH => benzene-1,2,4-triol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010645", "l": "AKAP5 recruits PPP3CB (PP2BB) to ROBO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22391", "l": "acetyl-CoA + N(6)-hydroxy-L-lysine <=> CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16172", "l": "ATP + L-glutamate + NH4(+) <=> ADP + H(+) + L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51930", "l": "(S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH => H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30872", "l": "2-deoxy-D-ribose + ATP => 2-deoxy-D-ribose 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59982", "l": "8-oxo-dGDP + H(+) + phosphate => 8-oxo-dGTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047538", "l": "2-carboxy-D-arabinitol-1-phosphatase activity", "d": ["Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39854", "l": "2 a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012016", "l": "FAHD1 dimer hydrolyses OA to PYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13640", "l": "H(+) + methane + NADH + O2 <=> H2O + methanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57444", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine", "d": [], "t": []}, {"i": "EC:3.4.17.17", "l": "\"tubulinyl-Tyr carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187382", "l": "Degradation of ubiquitinated SMAD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71181", "l": "FAH cleaves 4FAA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19052", "l": "(5R)-5-hydroxy-L-lysine + GTP <=> (5R)-5-phosphooxy-L-lysine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174445", "l": "RPA binds to the Flap on the C-strand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15854", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) => 17alpha-hydroxyprogesterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.248", "l": "\"cycloisomaltooligosaccharide glucanotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70481", "l": "TPI1 isomerizes GA3P to DHAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73869", "l": "serotonin(in) => serotonin(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63157", "l": "H2O + N-docosanoyl-taurine => docosanoate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193653", "l": "NGF homodimer binds to p75NTR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047324", "l": "phosphoenolpyruvate-glycerone phosphotransferase activity", "d": ["Catalysis of the reaction: glycerone + phosphoenolpyruvate = glycerone phosphate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47071", "l": "4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703434", "l": "FLT3 fusions recruit PIK3CA through PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63635", "l": "a long-chain fatty acyl-AMP + holo-[ACP] <=> a long-chain fatty acyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16467", "l": "2 Fe(II)-[cytochrome c553] + 2 H(+) + pyruvate => (R)-lactate + 2 Fe(III)-[cytochrome c553]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804006", "l": "NO and NO2 react to N2O3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848829", "l": "CBL autoubiquitinates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254291", "l": "ERBB4s80 binds STAT5A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451310", "l": "Activation of Edited Kainate receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015607", "l": "ABC-type fatty-acyl-CoA transporter activity", "d": ["Catalysis of the reaction ATP + H2O + fatty acyl CoA(Side 1) = ADP + phosphate + fatty acyl CoA(Side 2). A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352945", "l": "fructose 6-phosphate + ATP => fructose 1,6-bisphosphate + ADP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34205", "l": "aureusidin 6-O-beta-glucoside + H2O => 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63707", "l": "mycophenolate + UDP-alpha-D-glucuronate <=> H(+) + mycophenolate 7-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31735", "l": "3-oxocholan-24-oyl-CoA + NAD(+) = 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9659820", "l": "RB1 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45020", "l": "L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[ribosomal protein uL3] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.298", "l": "\"ribosomal protein uL3 N(5)-glutamine methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68611", "l": "Formation of ORC(1-5) complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11271", "l": "D-cysteine + H2O <=> H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13980", "l": "D-serine <=> NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11996", "l": "biphenyl-2-ol + H(+) + NADH + O2 = biphenyl-2,3-diol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839390", "l": "TGFBR3 complex binds to TGFBR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211164", "l": "AKT phosphorylates FOXO1A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757578", "l": "ALB binds PREDN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62442", "l": "4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1) => [(1->4)-alpha-D-galacturonosyl methyl ester](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70967", "l": "IDH3 complex decarboxylates isocitrate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70897", "l": "H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein] => N-terminal L-cysteinyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694337", "l": "Trimmed spike protein binds to calnexin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72372", "l": "dehydroepiandrosterone 3-sulfate(out) + succinate(in) => dehydroepiandrosterone 3-sulfate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9824892", "l": "MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25825", "l": "H2O + O2 + spermine => H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008872", "l": "glucarate dehydratase activity", "d": ["Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9709109", "l": "DHFR dimer binds DHFR inhibitors (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750942", "l": "USP14 deubiquitinates NLRC5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198714", "l": "ERK5 translocates to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19285", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol = a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol", "d": [], "t": []}, {"i": "EC:2.3.1.83", "l": "\"phosphatidylcholine--dolichol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690461", "l": "FKBP1A binds tacrolimus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20932", "l": "L-erythrulose 1-phosphate = dihydroxyacetone phosphate + formaldehyde", "d": [], "t": []}, {"i": "EC:4.1.2.2", "l": "\"ketotetrose-phosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018579", "l": "protocatechuate 4,5-dioxygenase activity", "d": ["Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65291", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine <=> CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42009", "l": "5alpha-pregnan-20beta-ol-3-one + NAD(+) => 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202966", "l": "Caspase mediated cleavage of HIP-55 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36693", "l": "CoA + H(+) + N-octadecanoylsphing-4-enine => octadecanoyl-CoA + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016996", "l": "endo-alpha-(2,8)-sialidase activity", "d": ["Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14704", "l": "2 CoA + NAD(+) <=> CoA-disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940959", "l": "Neurolysin degrades neurotensin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.195", "l": "\"L-ornithine N(5)-monooxygenase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14905", "l": "5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine", "d": [], "t": []}, {"i": "EC:2.4.2.14", "l": "\"amidophosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.120", "l": "\"cyclohexane-1-carbonyl-CoA reductase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19474", "l": "4-hydroxybenzoate + H(+) + NADH + O2 => 3,4-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.41", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64137", "l": "H2O + N-(9Z-octadecenoyl)-L-asparagine => (9Z)-octadecenoate + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.21", "l": "\"dipeptidase E\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102743", "l": "eriodictyol,NADPH:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: H+ + eriodictyol + NADPH + O2 = 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) + NADP + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44638", "l": "2,4-dinitrophenol + H(+) + methanol => 2,4-dinitroanisole + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50701", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196773", "l": "COASY phosphorylates DP-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75937", "l": "6-O-phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+) => ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564184", "l": "Collagen type IX degradation by MMP3,13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731228", "l": "NUDT1 hydrolyses 8-oxo-dATP to 8-oxo-dAMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190245", "l": "FGFR1b binds to FGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29915", "l": "L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) + UDP-alpha-D-glucose = alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917841", "l": "Acidification of Tf:TfR1 containing endosome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.32", "l": "\"glucomannan 4-beta-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70971", "l": "ACO2 isomerizes citrate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446209", "l": "Transfer of N-glycan to the protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18595", "l": "hexadecanal + phosphoethanolamine => sphinganine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38938", "l": "cyclohexane-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> cyclohex-1-ene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202164", "l": "Translocation of PDK1 to Plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875183", "l": "CBL monoubiquitinates activated MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357828", "l": "RIPK1 is cleaved by CASP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56045", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55709", "l": "[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) => [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419861", "l": "Melanospin is stimulated by light (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16787", "l": "an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53279", "l": "17beta-hydroxy-3,19-dioxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-hydroxy-3-oxo-19-nor-5alpha-androst-1-ene + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004958", "l": "prostaglandin F receptor activity", "d": ["Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25615", "l": "terpentedienyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28389", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine <=> di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047815", "l": "D-arabinonolactonase activity", "d": ["Catalysis of the reaction: D-arabinono-1,4-lactone + H2O = D-arabinonate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65064", "l": "dimethylallyl diphosphate + siccayne = diphosphate + pestalodiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79010", "l": "3-amino-4-hydroxybenzoate + ATP + H(+) + nitrite <=> 3-diazo-4-hydroxybenzoate + AMP + diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840949", "l": "ARSA removes sulfate from SM3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784959", "l": "BPHL hydrolyses VACV to ACV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448728", "l": "IL19 binds IL20RA:JAK1:IL20RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296045", "l": "Activation of Potassium transport channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008678", "l": "2-deoxy-D-gluconate 3-dehydrogenase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944240", "l": "Association of procollagen type III (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45463", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001850", "l": "complement component C3a binding", "d": ["Binding to a C3a product of the complement cascade."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450984", "l": "IDH2 dimer decarboxylates isocitrate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21407", "l": "chloride + O2 <=> chlorite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47701", "l": "H(+) + ketocytochalasin + NADPH + O2 => H2O + iso-precytochalasin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32412", "l": "(1R,2R,4S)-isodihydrocarveol + NAD(+) => (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47805", "l": "epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58868", "l": "24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}, {"i": "EC:1.14.18.11", "l": "\"plant 4alpha-monomethylsterol monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48350", "l": "a pseudouridine in RNA => a uridine in RNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67536", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32905", "l": "calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => calciol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49789", "l": "chenodeoxycholoyl-CoA + glycine => CoA + glycochenodeoxycholate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10751", "l": "H(+) + hydrogencarbonate <=> CO2 + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67135", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH <=> (1S,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64636", "l": "benzoyl-CoA + butan-1-ol = butyl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58521", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140132", "l": "iron-sulfur cluster carrier activity", "d": ["Binding to an iron-sulfur cluster and delivering it to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229283", "l": "LCNs bind lipids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102265", "l": "tRNA-dihydrouridine47 synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil47 in tRNA + NAD(P) = H+ + a uracil47 in tRNA + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73084", "l": "chrysoeriol + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + velutin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25487", "l": "(2E)-geranyl diphosphate <=> (1S,4R)-camphene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78575", "l": "(3S)-hydroxydocosanoyl-CoA = (2E)-docosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9609921", "l": "SGTA binds Tail-anchored protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797090", "l": "CCNK binds CDK12 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202241", "l": "Recruitment of SLP-76 to Gads (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28679", "l": "3-demethylubiquinol-8 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878654", "l": "ACP6 hydrolyses MYS-LPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611721", "l": "β1-agonists bind ADRB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951595", "l": "CALR, TAP, TAPBP dissociate from SEC22B:STX4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53716", "l": "H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP = phosphate + UDP-N-acetyl-alpha-D-muramate", "d": [], "t": []}, {"i": "EC:2.7.7.99", "l": "\"N-acetyl-alpha-D-muramate 1-phosphate uridylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0010297", "l": "heteropolysaccharide binding", "d": ["Binding to a heteropolysaccharide, a glycan composed of more than one type of monosaccharide residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15647", "l": "16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate => 16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61931", "l": "(R)-miconazole(in) + ATP + H2O <=> (R)-miconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38687", "l": "(4R)-hydroxysphinganine(in) + ATP + H2O = (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351208", "l": "Spermidine  => N-acetylated spermidine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8870469", "l": "RGGT geranylgeranylates RAB proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53367", "l": "5,6-dihydrouridine(47) in tRNA + NAD(+) <=> H(+) + NADH + uridine(47) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16854", "l": "N(6)-(1,2-dicarboxyethyl)-AMP => AMP + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9656244", "l": "DRD2 binds DA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77605", "l": "3-octadecanoyl-sn-glycero-1-phospho-(3'-octadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol) => 2 3-octadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019781", "l": "NEDD8 activating enzyme activity", "d": ["Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade."], "t": []}, {"i": "EC:6.2.1.64", "l": "\"E1 NEDD8-activating enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840532", "l": "OMA1 self-cleaves (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11479", "l": "glycerol 1-phosphate + H2O <=> glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989758", "l": "Expression of UGT1A9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52251", "l": "6 H2O + 4 Mn(3+) + O2 <=> 12 H(+) + 4 MnO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70423", "l": "an acyl-CoA + H2O = a carboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114284", "l": "Release of Cytochrome c from mitochondria (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877902", "l": "Activated AR binds RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592240", "l": "Formation of NRF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52627", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate <=> [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102759", "l": "campestanol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + campestanol + O2 + NADPH = 6-deoxycathasterone + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19751", "l": "[(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP => [(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159771", "l": "Furin cleaves pro-protein C to protein C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64680", "l": "benzoyl-CoA + ethanol = CoA + ethyl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853444", "l": "AURKA phosphorylates PHLDA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671876", "l": "Phosphorylated STAT5 Dissociates from Leptin Receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60673", "l": "NAD(+) + nerol => H(+) + NADH + neral", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60942", "l": "(9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166792", "l": "Conversion of C2 into C2a and C2b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218821", "l": "PDK1 phosphorylates PKC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952128", "l": "RUNX3 binds TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27628", "l": "beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate => D-erythrose 4-phosphate + D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444100", "l": "PROT mediates L-proline uptake (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53042", "l": "17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61301", "l": "5-deoxy-D-ribulose 1-phosphate => acetaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20025", "l": "gibberellin A3 + UDP-alpha-D-glucose = gibberellin A3 O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.176", "l": "\"gibberellin beta-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9633044", "l": "ESR binds STRN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420980", "l": "Activation of Ca permeable AMPA receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61473", "l": "a sphingoid base + hexadecanoyl-CoA => an N-hexadecanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15375", "l": "H(+) + palmatine + S-adenosyl-L-homocysteine => columbamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0033931", "l": "endogalactosaminidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-alpha-D-galactosaminidic linkages in poly(D-galactosamine)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189062", "l": "lactose + H2O => D-glucose + D-galactose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11265", "l": "H(+) + NADH + O2 => H2O2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50631", "l": "a 2-(omega-methylsulfanyl)alkylmalate <=> a 3-(omega-methylsulfanyl)alkylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37448", "l": "O2 + tetracenomycin F1 => H(+) + H2O + tetracenomycin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67034", "l": "4,5,8-trihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4,8-dihydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72316", "l": "glutathione(in) + leukotriene C4(out) => glutathione(out) + leukotriene C4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12443", "l": "H2O + L-saccharopine + NAD(+) <=> 2-oxoglutarate + H(+) + L-lysine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25842", "l": "5-dehydro-2-deoxy-D-gluconate => 5-deoxy-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202466", "l": "Interaction of Bcl10 to CARMA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798347", "l": "E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16358", "l": "A + succinate => AH2 + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31910", "l": "(S)-norcoclaurine + S-adenosyl-L-methionine <=> (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102911", "l": "(-)-secoisolariciresinol dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-secoisolariciresinol + NAD = H+ + (-)-lactol + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0160002", "l": "ADP-D-ribose modification-dependent protein binding", "d": ["Binding to a protein upon ADP-ribosylation of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034921", "l": "cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-4,5-dihydroxy-4,5-dihydropyrene = 4,5-dihydroxypyrene + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68661", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate => 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30502", "l": "H(+) + N,N-dihydroxy-L-valine <=> (E)-2-methylpropanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75841", "l": "H(+)(out) + K(+)(out) + Na(+)(in) + serotonin(in) => H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2533950", "l": "Fibronectin degradation by MMP14 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48352", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16943", "l": "H2O + N-acetylisatin => N-acetylindoxyl + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54237", "l": "1,2-didecanoyl-sn-glycerol + CDP-choline => 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689861", "l": "Recruitment of XPA and release of CAK  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6805061", "l": "CK2 binds FACT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373727", "l": "Nephrin binds CD2AP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198314", "l": "DAG stimulates protein kinase C-delta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58941", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADH => all-trans-lycopaoctaene + diphosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60745", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone => CoA + pyrethrin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73613", "l": "CTP(in) + dCDP(out) => CTP(out) + dCDP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47493", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isodeoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71519", "l": "uridine(out) = uridine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944454", "l": "mTORC1 phosphorylates MAF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34342", "l": "(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042018", "l": "interleukin-22 receptor activity", "d": ["Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0019961", "l": "interferon binding", "d": ["Binding to an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52851", "l": "5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine <=> 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23036", "l": "2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48879", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O <=> L-seryl-[protein] + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38398", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O <=> (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12213", "l": "9H-fluoren-9-ol + NADP(+) => 9H-fluoren-9-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35927", "l": "paromamine + UDP-alpha-D-glucose = 3''-deamino-3''-hydroxykanamycin C + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.29", "l": "\"[heparan sulfate]-glucosamine 3-sulfotransferase 2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213244", "l": "Loading of antigenic peptides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424476", "l": "Activation of RAC1 by VAV2/3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73112", "l": "S-adenosyl-L-methionine + scutellarein 4'-methyl ether => ladanein + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20579", "l": "aminohydroquinone => 3-hydroxyaminophenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655483", "l": "USP1 autocleavage (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001873", "l": "polysaccharide immune receptor activity", "d": ["Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226999", "l": "ADD1:ADD3 binds DMTN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46214", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + formate => H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65767", "l": "a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O <=> (2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35917", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33021", "l": "(3S)-6-acetamido-3-aminohexanoate + CoA + H(+) => (3S)-3,6-diaminohexanoate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14880", "l": "ATP + L-glutamate <=> ADP + L-glutamyl 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38287", "l": "(3S)-citramalate + succinyl-CoA = (3S)-citramalyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72696", "l": "UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) => UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71673", "l": "glycyl-L-glutamine(in) + H(+)(in) => glycyl-L-glutamine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42603", "l": "AH2 + prostaglandin G2 <=> A + H2O + prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8979071", "l": "KDM6B binds iron (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21289", "l": "D-glucose + sn-glycerol 3-phosphate => D-glucose 6-phosphate + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.319", "l": "\"isoeugenol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647631", "l": "GSDMD (1-275) binds PIPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42090", "l": "all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11552", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + acetate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.71", "l": "\"acetylalkylglycerol acetylhydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987097", "l": "IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53782", "l": "beta-muricholoyl-CoA + lithocholate => beta-muricholate + lithocholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30589", "l": "2-demethylmenaquinone-8 + dimethyl sulfide + H2O => 2-demethylmenaquinol-8 + dimethyl sulfoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43636", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}, {"i": "EC:2.3.1.286", "l": "\"protein acetyllysine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38804", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75481", "l": "S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out) => S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250979", "l": "botG:SYT1:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60414", "l": "[N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+) => H2O + monoglucosyl-enterobactin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9846477", "l": "A4GALT transfers galactose to LacCer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40561", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+) => dTDP-beta-L-evernosamine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19656", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106423", "l": "tubulin-tyrosine carboxypeptidase", "d": ["Catalysis of the reaction: C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69127", "l": "Formation of the Flap Intermediate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12726", "l": "D-iditol + NAD(+) => H(+) + keto-D-sorbose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41724", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199583", "l": "KIR2DS2 interacting with HLA-C group 1 (Cw3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.42", "l": "\"flavone 3'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68615", "l": "Formation of ORC(1-6) complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48889", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione => (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68821", "l": "(2Z,6E)-farnesyl diphosphate + H2O => (6E)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420206", "l": "Phosphorylation of SRC-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40792", "l": "H2O + hexacosanoyl-CoA => CoA + H(+) + hexacosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65793", "l": "fluometuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168423", "l": "JAK2 phosphorylation of IRS-1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38708", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14674", "l": "a polar amino acid(out) + ATP + H2O => a polar amino acid(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018747", "l": "RHOQ GEFs activate RHOQ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113449", "l": "RNA Polymerase III Transcriptional Pause at Terminator Sequence (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018774", "l": "RHOBTB1 binds GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18950", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59412", "l": "2-oxosuccinamate + H2O = NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983259", "l": "Kinesins move along microtubules consuming ATP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32273", "l": "4-methyl-2-oxopentanoate + CO2 + NADH => (2R,3S)-3-isopropylmalate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71226", "l": "chloride(out) + 2 Na(+)(out) + taurine(out) <=> chloride(in) + 2 Na(+)(in) + taurine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030564", "l": "tRNA 2'-O-ribose methylation guide activity", "d": ["Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9718020", "l": "PTGFR binds PTGFR agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928620", "l": "PAK1 autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112282", "l": "CAMK4 enters the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58573", "l": "O-acetyl-15alpha-stemmadenine + O2 => H2O2 + precondylocarpine acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76386", "l": "CYP1A2 S-demethylates 6MMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68957", "l": "S-adenosyl-L-methionine + scopoletin => H(+) + S-adenosyl-L-homocysteine + scoparone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64436", "l": "glycylglycyl-L-isoleucine(out) + H(+)(out) = glycylglycyl-L-isoleucine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070042", "l": "rRNA (uridine-N3-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59371", "l": "1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67741", "l": "N-acetyl-beta-neuraminate => aceneuramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76729", "l": "7-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1470010", "l": "Dimerization of STATs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9664879", "l": "ATM:PEX5 binds ATM (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41607", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71777", "l": "acetoacetate(in) + H(+)(in) => acetoacetate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28624", "l": "(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17050", "l": "3-demethylubiquinol-9 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71518", "l": "hypoxanthine(out) <=> hypoxanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62309", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) => (+)-malbrancheamide B + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0004774", "l": "succinate-CoA ligase activity", "d": ["Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23977", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + ATP => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74575", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] = N(alpha)-acetyl-L-methionine + N-terminal L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44304", "l": "a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA = a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5195402", "l": "CDK1 phosphorylates LPIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41764", "l": "a ganglioside GD3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT3 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44250", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29278", "l": "L-isoleucine(in) + Na(+)(in) <=> L-isoleucine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198813", "l": "GSTO dimers reduce DeHA to AscH- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-398185", "l": "LARG binds plexin B1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102400", "l": "dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N,N-dimethyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose = 2 S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11862", "l": "ADP + H(+) + N(tele)-phospho-L-histidyl-[protein] => ATP + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58847", "l": "(6E)-8-hydroxygeranial + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102229", "l": "amylopectin maltohydrolase activity", "d": ["Catalysis of the reaction: n H2O + an exposed unphosphorylated, unbranched malto-oligosaccharide tail on amylopectin = amylopectin + maltose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59643", "l": "D-xylotetraose + O2 <=> D-xylotetraono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11444", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.9", "l": "\"chondro-4-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21630", "l": "acetate + androst-4-ene-3,17-dione + H2O + NADP(+) => 17alpha-hydroxyprogesterone + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036054", "l": "protein-malonyllysine demalonylase activity", "d": ["Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9854368", "l": "ROS,RNS oxidize ACO2:4Fe-4S (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419254", "l": "5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58517", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102954", "l": "dalcochinase activity", "d": ["Catalysis of the reaction: dalcochinin-8'-O-beta-glucoside + H2O = dalcochinin + D-glucopyranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047857", "l": "dihydrouracil oxidase activity", "d": ["Catalysis of the reaction: 5,6-dihydrouracil + O2 = H2O2 + uracil."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6795667", "l": "MDM2 translocates to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56151", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphocholine <=> CoA + hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46558", "l": "7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72549", "l": "2-oxoglutarate(out) + taurocholate(in) => 2-oxoglutarate(in) + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40134", "l": "(9Z)-hexadecenoyl-CoA + H2O <=> (9Z)-hexadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22714", "l": "adenosylcob(III)inamide-GDP + diphosphate => adenosylcob(III)inamide phosphate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848939", "l": "PTK6 binds KHDRBS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13971", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + diphosphate + GMP => a 3'-end 3'-phospho-ribonucleotide-RNA + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35412", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3-O-beta-D-glucoside => an anthocyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside] + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71443", "l": "3-O-methyl-L-dopa(out) + L-phenylalanine(in) = 3-O-methyl-L-dopa(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656775", "l": "Cysmethynil binds ICMT:Zn2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847880", "l": "CYTH proteins bind ARF1:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53471", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749590", "l": "ASA- acetylates ALB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55355", "l": "all-trans-retinol <=> 13-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17755", "l": "(S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine => S-(5-deoxy-D-ribos-5-yl)-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38102", "l": "a ribonucleoside 5'-triphosphate + phytyl phosphate <=> a ribonucleoside 5'-diphosphate + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38163", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50991", "l": "prostaglandin F2alpha(out) <=> prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61770", "l": "H(+) + rebaudioside D + UDP => rebaudioside A + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71582", "l": "CDP(out) + CDP-L-ribitol(in) <=> CDP(in) + CDP-L-ribitol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68242", "l": "L-methionine(out) + Na(+)(out) => L-methionine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640167", "l": "RRAGA,B exchanges GDP for GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72277", "l": "oxalate(out) + sulfate(in) => oxalate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71849", "l": "LDH tetramer reduces PYR to LACT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46285", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448629", "l": "IL33 binds IL1RL1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78272", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-delta-cadinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71361", "l": "17beta-estradiol 17-sulfate(in) + 2 Na(+)(in) => 17beta-estradiol 17-sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247497", "l": "ERBB3 binds neuregulins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57257", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP => GTP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48498", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935972", "l": "TJP1 (ZO-1) gene expression is stimulated by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606789", "l": "ARSB hydrolyses DS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047882", "l": "estradiol 6-beta-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + estradiol-17beta + O2 = 6beta-hydroxyestradiol-17beta + A + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60504", "l": "1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31447", "l": "6-amino-2-oxohexanoate + H2O2 = 5-aminopentanoate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42011", "l": "5alpha-pregnan-20beta-ol-3-one + NAD(+) <=> 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57294", "l": "a guanosine in RNA + glycolate + H(+) => an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40982", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200396", "l": "Creatine transport across the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43539", "l": "2 D-glyceraldehyde 3-phosphate <=> 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788061", "l": "Fibronectin degradation by ADAM8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51904", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28729", "l": "Cu(2+)(out) + H(+)(out) => Cu(2+)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180013", "l": "lysophosphatidylserine flippase activity", "d": ["Catalysis of the movement of a lysophosphatidylserine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392263", "l": "AVP(20-28) binds AVPR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51938", "l": "glutathione disulfide + hydroquinone => 2-(glutathione-S-yl)-hydroquinone + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73951", "l": "(2E,6E)-farnesyl diphosphate = beta-maaliene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74959", "l": "(3R)-3-isocyanylbutanoate + ATP + holo-[ACP] = (3R)-3-isocyanylbutanoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193703", "l": "IKKbeta is activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25624", "l": "geranylgeranyl diphosphate <=> tuberculosinyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0042314", "l": "bacteriochlorophyll binding", "d": ["Binding to bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757578", "l": "ALB binds PREDN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675790", "l": "MTORC1 dissociates from ULK complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690493", "l": "RHOB binds effectors on endosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299359", "l": "Activation of TALK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26394", "l": "all-trans-zeaxanthin + 2 O2 => 2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20944", "l": "S-adenosyl-L-methionine + theobromine = caffeine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029992", "l": "Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352867", "l": "glucose [cytosol] <=> glucose [extracellular] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40285", "l": "CoA + O-hexadecanedioyl-L-carnitine => (R)-carnitine + hexadecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16416", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] <=> L-lysyl-[glycine-cleavage complex H protein] + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399712", "l": "Activation of Ca permeable AMPA receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432825", "l": "HMGB1 binds TLR4:LY96 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9861734", "l": "PDH E1 decarboxylates PYR, transferring acetyl to DLAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8937807", "l": "SRC phosphorylates RUNX3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983422", "l": "Disassembly of COPII coated vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72431", "l": "(E)-caffeate + ATP + H(+) = (E)-caffeoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018810", "l": "trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity", "d": ["Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866277", "l": "AP-2 directly binds some endocytic cargo (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390835", "l": "DRD1,5 bind DA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18385", "l": "acetone + 2 ATP + 3 H2O + hydrogencarbonate = acetoacetate + 2 AMP + 4 H(+) + 4 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37981", "l": "2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine => 2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37319", "l": "ATP + glycyl-L-methionine(out) + H2O = ADP + glycyl-L-methionine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63795", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59792", "l": "H2O + NADP(+) + yersinopine = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003833", "l": "beta-alanyl amine synthase activity", "d": ["Catalysis of the synthesis of beta-alanyl amine conjugate from a precursor biogenic amine, such as dopamine or histamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32507", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O = 6-hydroxy-3-isopropenylheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2464822", "l": "RDH12 reduces atRAL to atROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986972", "l": "IL24 binds IL20RA:JAK1:IL20RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034955", "l": "2,3-dihydroxydiphenyl ether dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxydiphenyl ether + O2 + H2O = 2-hydroxymuconate + phenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61862", "l": "epoxybetaenone + H2O + NADP(+) => dehydroprobetaenone I + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9844587", "l": "GAL3ST1 transfers sulfate to GalCer,LacCer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25668", "l": "beta-pinene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624494", "l": "RAF1 binds p21 RAS:GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36622", "l": "2-hydroxydocosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69267", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate <=> an isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35625", "l": "gamma-D-glutamyl-D-glutamate + NH4(+) => D-glutamate + D-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41516", "l": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55121", "l": "4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43632", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26522", "l": "(2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.117", "l": "\"2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229132", "l": "AP4 binds APP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754130", "l": "CDK4 inhibitors bind CDK4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390930", "l": "5-HT2 receptor can bind serotonin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31175", "l": "(2E)-2-methylpropenoyl-CoA + H2O = (S)-3-hydroxyisobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17870", "l": "5,6,7,8-tetrahydropteridine + NAD(+) => 6,7-dihydropteridine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68800", "l": "H2O + nigerose = alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200646", "l": "Cytosolic folate export across the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66239", "l": "IC-asc-C9-CoA + O2 <=> H2O2 + IC-asc-DeltaC9-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34253", "l": "1-deoxy-3-dehydrosphinganine + H(+) + NADPH => 1-deoxysphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30663", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = hapalindole H", "d": [], "t": []}, {"i": "EC:5.5.1.31", "l": "\"hapalindole H synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004837", "l": "tyrosine decarboxylase activity", "d": ["Catalysis of the reaction: L-tyrosine = tyramine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199935", "l": "MSK1 activates CREB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68816", "l": "(2Z,6E)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24684", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH => 5,10-methylenetetrahydromethanopterin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033453", "l": "GCU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GCU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33180", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60800", "l": "2-oxoglutarate + gibberellin A53 + O2 = CO2 + gibberellin A44 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52158", "l": "(R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139899", "l": "Sequestration of BAD protein by 14-3-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.45", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76878", "l": "H2O + hexan-2-amine + NAD(+) <=> H(+) + hexan-2-one + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10611", "l": "(E)-cinnamate + O2 + reduced [NADPH--hemoprotein reductase] <=> (E)-4-coumarate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60882", "l": "a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+) => a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70979", "l": "MDH2 dimer dehydrogenates MAL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167415", "l": "G-protein alpha subunit is inactivated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21826", "l": "L-glutamate + oxaloacetate => 2-oxoglutarate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044548", "l": "S100 protein binding", "d": ["Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32643", "l": "2 Fe(III)-[cytochrome c] + H2O + lupanine = 17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.17.2.2", "l": "\"lupanine 17-hydroxylase (cytochrome c)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53348", "l": "5,6-dihydrouridine(20a) in tRNA + NAD(+) = H(+) + NADH + uridine(20a) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.26", "l": "\"adenosylcobinamide-GDP ribazoletransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404195", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030267", "l": "glyoxylate reductase (NADPH) activity", "d": ["Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46472", "l": "4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602458", "l": "Activation of proMMP10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19157", "l": "D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.82", "l": "\"xylonate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9861667", "l": "DLAT trimer transfers acetyl to CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396370", "l": "VTN binds collagens II, III and V (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31727", "l": "FADH2 + O2 + styrene = (S)-styrene oxide + FAD + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.11", "l": "\"styrene monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14926", "l": "D-mannitol 1-phosphate + NADP(+) => D-mannose 6-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749215", "l": "MCM8 binds CDC6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11723", "l": "ATP + 2 H2O + N-methylhydantoin <=> ADP + 2 H(+) + N-carbamoylsarcosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191405", "l": "Two FPP molecules dimerize to form presqualene diphosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004908", "l": "interleukin-1 receptor activity", "d": ["Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604712", "l": "Initial activation of proMMP7 by trypsin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58174", "l": "beta-pinacene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73934", "l": "chloride + FADH2 + griseophenone C + O2 <=> FAD + griseophenone B + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102999", "l": "UDP-glucose:2-hydroxylamino-4,6-dinitrotoluene-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 2-hydroxylamino-4,6-dinitrotoluene = 2-hydroxylamino-4,6-dinitrotoluene-O-glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.-", "l": "\"With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36587", "l": "an aldopyranose + NADP(+) = aldono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40775", "l": "2-amino-2-phenylacetonitrile + H(+) + 2 H2O = D-alpha-phenylglycine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48833", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5220959", "l": "TDG excises 5-formylcytosine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015345", "l": "ferric enterobactin:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38090", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17277", "l": "6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.12", "l": "\"phosphogluconate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14255", "l": "diphosphate + GDP + H(+) => guanosine 3',5'-bis(diphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64325", "l": "(11Z)-octadecenoyl-CoA + cholesterol => cholesteryl (11Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045549", "l": "9-cis-epoxycarotenoid dioxygenase activity", "d": ["Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al."], "t": []}, {"i": "EC:1.13.11.51", "l": "\"9-cis-epoxycarotenoid dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31599", "l": "FMNH2 + NADH + O2 + thymine = (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15750", "l": "(S)-mandelate + A => AH2 + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23033", "l": "2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450387", "l": "HuR binds the CRM1 nuclear export machinery (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606622", "l": "GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44477", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acetyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45533", "l": "H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30037", "l": "benzene-1,2,4-triol + CO2 + H2O + NAD(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13352", "l": "jasmonate + S-adenosyl-L-methionine <=> methyl (-)-jasmonate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21322", "l": "AH2 + keto-L-sorbose => A + D-sorbitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43410", "l": "beta-D-galactosyl-(1<->1')-sphinganine + H(+) + UDP => sphinganine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44099", "l": "decan-1-ol + hexadecanoyl-CoA <=> CoA + decanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56911", "l": "(7S)-O-acetylsalutaridinol <=> acetate + H(+) + thebaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944233", "l": "Association of procollagen type XIX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48130", "l": "(2E,6E)-farnesyl phosphate + H(+) + phosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202174", "l": "Activation of ZAP-70 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445448", "l": "HHIP binds Hedgehog (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102055", "l": "12-hydroxyjasmonate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + a 12-hydroxyjasmonate = adenosine 3',5'-bismonophosphate + a 12-hydroxyjasmonate sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70181", "l": "alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose => 2 D-maltotetraose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32194", "l": "H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28155", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52967", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate <=> H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61776", "l": "rebaudioside D + UDP-alpha-D-glucose = H(+) + rebaudioside M + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981539", "l": "C3b binds to cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47399", "l": "H2O + octadecanoate ester <=> an aliphatic alcohol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362417", "l": "Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198347", "l": "AKT phosphorylates BAD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170964", "l": "FRS2 binds to active TrkA receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418849", "l": "DAPK binds UNC5B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106310", "l": "protein serine kinase activity", "d": ["Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64631", "l": "acetyl-CoA + octan-1-ol <=> CoA + octyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56069", "l": "an N-acetyl-alpha-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17051", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-9 => 3-demethylubiquinol-9 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193695", "l": "IRAK interacts with TRAF6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033509", "l": "USP9X binds Ub:PEX5L (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58281", "l": "4 ATP => cyclic tetraadenylate + 4 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694421", "l": "PP6 dephosphorylates SEC24 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034951", "l": "o-hydroxylaminobenzoate mutase activity", "d": ["Catalysis of the reaction: o-hydroxylaminobenzoate = 3-hydroxyanthranilate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061542", "l": "3-demethylubiquinol-n 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a 3-demethylubiquinol = S-adenosyl-L-homocysteine + a ubiquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823729", "l": "Expression of SOX17 in definitive endoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022141", "l": "Prolysyl oxidase activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68828", "l": "borneol + NAD(+) = camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701485", "l": "Active ALK binds JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050190", "l": "phosphoglucokinase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = alpha-D-glucose 1,6-bisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865482", "l": "KMT2A (MLL) binds RUNX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14853", "l": "4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl-CoA + chloride + H(+)", "d": [], "t": []}, {"i": "EC:3.8.1.7", "l": "\"4-chlorobenzoyl-CoA dehalogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41882", "l": "dodecanoyl-[ACP] + NADP(+) => (2E)-dodecenoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673284", "l": "GTP-bound RAC1 contributes to MAPK8 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046408", "l": "chlorophyll synthetase activity", "d": ["Catalysis of the reaction: chlorophyllide a + 2 H+ + phytyl diphosphate = chlorophyll a + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78365", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-O-acyl-N-(acetyl)-sphing-4-enine => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042658", "l": "MHC class II protein binding, via antigen binding groove", "d": ["Binding to the antigen binding groove of major histocompatibility complex class II molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29071", "l": "a ubiquinone + formate + H(+) = a ubiquinol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192061", "l": "CYP46A1 24-hydroxylates CHOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23705", "l": "GTP + 4 H2O => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140037", "l": "SUMO-modified protein reader activity", "d": ["A molecular adaptor that recognizes and binds a target protein containing a SUMO modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.25", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710254", "l": "GSDME oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70267", "l": "hydrogencarbonate(in) + Na(+)(in) = hydrogencarbonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37072", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57575", "l": "7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624798", "l": "LBR binds KPNB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75856", "l": "Abortive Initiation Before Second Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60448", "l": "an S-substituted glutathione + H2O = glycine + S-substituted gamma-glutamyl-L-cysteine", "d": [], "t": []}, {"i": "EC:3.4.17.25", "l": "\"glutathione-S-conjugate glycine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75373", "l": "guanosine(out) => guanosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18565", "l": "19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine = 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.3.1.161", "l": "\"lovastatin nonaketide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810161", "l": "HOXA3 chromatin is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5227009", "l": "ABCF1 binds EIF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45654", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10930", "l": "ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23727", "l": "H2O + O2 + pyridoxal <=> 4-pyridoxate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17782", "l": "H2O + N-formyl-L-methionine => formate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51862", "l": "8-geranylumbelliferone + diphosphate => (2E)-geranyl diphosphate + umbelliferone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844447", "l": "NLRP1 senses MDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625416", "l": "Anterograde IFT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749609", "l": "BCHE hydrolyzes ASA- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15544", "l": "DIMBOA + UDP-alpha-D-glucose <=> DIMBOA beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19216", "l": "acetyl-CoA + an S-substituted L-cysteine <=> an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15035", "l": "H2O2 + pyridoxal => O2 + pyridoxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27834", "l": "a menaquinone + succinate = a menaquinol + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018766", "l": "RHOU binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23301", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate => (2Z,6E)-farnesyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.49", "l": "\"L-allo-threonine aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31849", "l": "shionone => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209840", "l": "Two DITs combine to form thyroxine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0016160", "l": "amylase activity", "d": ["Catalysis of the hydrolysis of amylose or an amylose derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66931", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O <=> a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78000", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol => a 1-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35138", "l": "L-alanyl-L-glutamate(out) <=> L-alanyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26530", "l": "4-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.120", "l": "\"4-hydroxybutanoyl-CoA dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24297", "l": "(S)-dihydroorotate + H2O => H(+) + N-carbamoyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102589", "l": "cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + malonyl-CoA(5-) = cyanidin 3-O-(3''', 6''-O-dimalonyl-beta-glucopyranoside) + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4647593", "l": "EP400 binds CDKN1A promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8986480", "l": "IL26:IL20RA:JAK1 binds IL10RB:TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64930", "l": "dAMP + H(+) + phosphate => dADP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27562", "l": "(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25221", "l": "H(+) + L-cysteate = CO2 + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047190", "l": "2-acylglycerophosphocholine O-acyltransferase activity", "d": ["Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = 1,2-diacyl-sn-glycero-3-phosphocholine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2430535", "l": "MASTL phosphorylates ENSA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "65.829330609318518", "identifiers": [{"i": "GO:0016407", "l": "acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51612", "l": "(R)-2-hydroxyglutarate + oxaloacetate = (R)-malate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014456", "l": "GDIs block activation of RHOG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20744", "l": "NADP(+) + prostaglandin D2 = 15-oxoprostaglandin D2 + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.196", "l": "\"15-hydroxyprostaglandin-D dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.25", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030777", "l": "(S)-scoulerine 9-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0000257", "l": "nitrilase activity", "d": ["Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23024", "l": "[(1->4)-beta-D-glucosyl](n) + phosphate = [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.49", "l": "\"cellodextrin phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864729", "l": "PITX2 gene expression is stimulated by TFAP2A,TFAP2C homodimers:CITED2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67994", "l": "(Z)-1,2-dichloroethene + A + chloride + H(+) => AH2 + trichloroethene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3772430", "l": "CTNNBIP1 binds beta-catenin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65264", "l": "3-hydroxypentacecilide A + A = AH2 + chrodrimanin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77383", "l": "H(+) + hnu + octanoate = CO2 + heptane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77381", "l": "CO2 + tridecane => H(+) + hnu + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63598", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32992", "l": "2 a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050616", "l": "secologanin synthase activity", "d": ["Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27436", "l": "2 glutathione amide + NAD(+) <=> glutathione amide disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23227", "l": "trans-zeatin + UDP-alpha-D-glucose <=> H(+) + O-beta-D-glucosyl-trans-zeatin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15097", "l": "5-formimidoyltetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40379", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-532603", "l": "Nephrin mediated activation of N-WASP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77273", "l": "1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801109", "l": "CHM binds RGGT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362522", "l": "ALDHs oxidise atRAL to atRA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373739", "l": "Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22941", "l": "ATP + L-arginine => ADP + H(+) + N(omega)-phospho-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12658", "l": "a (2S)-2-methylacyl-CoA => a (2R)-2-methylacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25427", "l": "diphosphate + GMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696947", "l": "USP47 deubiquitinates POLB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672083", "l": "KTN1 binds Kinesin-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76416", "l": "Benzene is hydroxylated to phenol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47454", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA => (2E,5Z)-tetradecadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35713", "l": "acetyl-CoA + succinate => acetate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12885", "l": "GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp) = GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp)", "d": [], "t": []}, {"i": "EC:2.4.1.110", "l": "\"tRNA-queuosine alpha-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17508", "l": "H2O + N-(long-chain fatty acyl)ethanolamine <=> a long-chain fatty acid + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50821", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) => H(+) + NADPH + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163090", "l": "Elongation Of The Telomeric Chromosome End (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12449", "l": "(R)-pantothenate + H2O => (R)-pantoate + beta-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69465", "l": "2 [thioredoxin]-dithiol + arsenic triglutathione + H2O + 2 S-adenosyl-L-methionine => 2 [thioredoxin]-disulfide + dimethylarsinous acid + 3 glutathione + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694462", "l": "ABHD6,12 hydrolyse 3AG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672973", "l": "MAP2Ks phosphorylate MAPKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21495", "l": "2,3-dihydroxybenzoate + H(+) <=> catechol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050458", "l": "decylhomocitrate synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + H2O + lauroyl-CoA = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10132", "l": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.25", "l": "\"benzoate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141101", "l": "tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + uridine44 in tRNASer = 2'-O-methyluridine44 in tRNASer + H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.222", "l": "\"O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653886", "l": "B4GALT1 binds LALBA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340214", "l": "CYGB binds O2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382055", "l": "Grb7 binds to the active PDGF receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37316", "l": "glycyl-L-glutamine + H2O => glycine + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31731", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.12", "l": "\"3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67183", "l": "ATP + glycine + L-glutamyl-[protein] <=> ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78958", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45280", "l": "12-(phosphooxy)octadecanoate + H2O = 12-hydroxyoctadecanoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21317", "l": "H2O + phorbol 12,13-dibutanoate => butanoate + H(+) + phorbol 13-butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.752469279128519", "identifiers": [{"i": "GO:0005198", "l": "structural molecule activity", "d": ["The action of a molecule that contributes to the structural integrity of a complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13484", "l": "ATP + L-methionine + tRNA(Met) <=> AMP + diphosphate + L-methionyl-tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75172", "l": "Formation of RAD50:MRE11 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168923", "l": "Collagen type XVIII endostatin release (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660665", "l": "Caspase-8 binds MALT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45304", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18770", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate => 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18004", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686587", "l": "ABL1 phosphorylates RAD52 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30796", "l": "2-oxoadipate + CoA + NAD(+) => CO2 + glutaryl-CoA + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667914", "l": "ALK binds ligand midkine (MDK) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13114", "l": "2-acetamidofluorene + H2O + NADP(+) => H(+) + N-hydroxy-2-acetamidofluorene + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5607734", "l": "PKC-delta translocates to plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41215", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196857", "l": "PANK2 phosphorylates PanK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9670114", "l": "Histone H3.3 deposition at telomere (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592250", "l": "NRF1, PPRC1:HCFC1:NRF2 bind the TFB1M promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23954", "l": "2-phenylethylamine + acetate => H2O + N-(2-phenylethyl)acetamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65178", "l": "AH2 + protoaustinoid B => A + protoaustinoid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372697", "l": "Crk binding to p130cas (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33618", "l": "ATP + CoA + octadecanoate <=> AMP + diphosphate + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950183", "l": "IL12B binds IL23A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75967", "l": "(6-hydroxyhexanoyl)n + H2O = (6-hydroxyhexanoyl)n-1 + 6-hydroxyhexanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73051", "l": "hydrogencarbonate(in) + taurocholate(out) = hydrogencarbonate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004455", "l": "ketol-acid reductoisomerase activity", "d": ["Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9035227", "l": "TXN2 binds CysS248-MPST (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68847", "l": "(2Z,6E)-farnesyl diphosphate <=> (Z)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14940", "l": "all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30897", "l": "3-aminopropanal + H2O2 + NH4(+) => H2O + O2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63711", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37721", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64415", "l": "n H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> n H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46619", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769419", "l": "NPAS4 binds RET gene enhancer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.-", "l": "\"Carboxy-lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77459", "l": "3-formylthiophene + hydrogen cyanide = (2S)-2-hydroxy-2-(thiophen-3-yl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6805981", "l": "HMGB1 release from cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23089", "l": "ATP + O-alkylglycerone => 1-O-alkylglycerone 3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40962", "l": "2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine <=> 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74890", "l": "2',3'-cGAMP(in) + ATP + H2O <=> 2',3'-cGAMP(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56033", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19377", "l": "NADP(+) + reduced riboflavin = 2 H(+) + NADPH + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937337", "l": "TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982765", "l": "Growth hormone forms dimers and oligomers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46961", "l": "butanoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (2E)-butenoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12562", "l": "H(+) + hydroquinone O-beta-D-glucopyranoside + UDP => hydroquinone + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36973", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-allose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876497", "l": "InlA binds CDH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0030291", "l": "protein serine/threonine kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5444523", "l": "Formation of MSH1:PMS2 Complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29431", "l": "ATP + phosphate = ADP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24104", "l": "7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine", "d": [], "t": []}, {"i": "EC:2.4.2.29", "l": "\"tRNA-guanosine(34) preQ1 transglycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166220", "l": "FA anion diffuses laterally to UCP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37647", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661219", "l": "MT1A binds cadmium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990450", "l": "linear polyubiquitin binding", "d": ["Binding to a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11352", "l": "acetate + ATP = acetyl phosphate + ADP", "d": [], "t": []}, {"i": "EC:2.7.2.1", "l": "\"acetate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50161", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74416", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71120", "l": "H(+) + hispidin + NADPH + O2 => 3-hydroxyhispidin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299297", "l": "Activation of THIK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6796647", "l": "TP53 stimulates CCNK expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951966", "l": "EP300 acetylates RUNX3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170159", "l": "Translocation of Cdc25 to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47840", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + gamma-L-glutamyltyramine = (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.131", "l": "\"(4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018823", "l": "cyclohexa-1,5-dienecarbonyl-CoA hydratase activity", "d": ["Catalysis of the reaction: cyclohexa-1,5-diene-1-carbonyl-CoA + H2O = 6-hydroxycyclohex-1-enecarbonyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637651", "l": "esxA translocates from Mtb cytosol to the host's ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0086080", "l": "protein binding involved in heterotypic cell-cell adhesion", "d": ["Binding to a protein or protein complex contributing to the adhesion of two different types of cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.8", "l": "\"limonene dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32622", "l": "L-threo-7,8-dihydrobiopterin + NADP(+) <=> H(+) + NADPH + sepiapterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65101", "l": "a 1-acylglycerol + hexadecanoyl-CoA => an hexadecanoyl-acylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714483", "l": "RAC2 translocates to the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43295", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044590", "l": "iron-sulfur-molybdenum cofactor binding", "d": ["Binding to iron molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32330", "l": "10-hydroxy-alpha-humulene + NAD(+) <=> H(+) + NADH + zerumbone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18293", "l": "ATP + CoA + oxalate = AMP + diphosphate + oxalyl-CoA", "d": [], "t": []}, {"i": "EC:6.2.1.8", "l": "\"oxalate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36149", "l": "benzyl acetate + CoA => acetyl-CoA + benzyl alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265894", "l": "BRIP1 (FANCJ) helicase functions in direct unwinding of DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37220", "l": "A + D-valine + H2O => 3-methyl-2-oxobutanoate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46395", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004829", "l": "threonine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33678", "l": "H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) <=> H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26098", "l": "(4R)-limonene + H(+) + NADPH + O2 => H2O + limonene 1,2-epoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63367", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.116", "l": "\"D-arabinose 1-dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17164", "l": "2,6-dioxo-6-phenylhexa-3-enoate + H2O <=> 2-oxopent-4-enoate + benzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59730", "l": "(2S)-ethylmalonyl-CoA => (2R)-ethylmalonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.110", "l": "\"aromatic 2-oxoacid reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209960", "l": "Diiodinated tyrosine can be deiodinated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45755", "l": "(3E)-decenoyl-CoA <=> (2E)-decenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17533", "l": "2-oxoglutarate + an aromatic L-alpha-amino acid = an aromatic oxo-acid + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17763", "l": "an aromatic aldehyde + H(+) + NADPH => an aromatic primary alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106430", "l": "dihydroorotate dehydrogenase (quinone) activity", "d": ["(S)-dihydroorotate + a quinone = orotate + a quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.315", "l": "\"11-cis-retinol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818937", "l": "MEN1 binds MLL1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24553", "l": "5alpha-cholestan-3-one + NADP(+) => cholest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222512", "l": "Nitric oxide oxidizes to nitrosyl ion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11403", "l": "GDP-6-deoxy-alpha-D-altrose + sordaricin <=> 4'-O-demethylsordarin + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71611", "l": "(S)-malate(in) + malonate(out) = (S)-malate(out) + malonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56288", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.74", "l": "\"albendazole monooxygenase (hydroxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072548", "l": "dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity", "d": ["Catalysis of the reaction: dicoumaroyl monocaffeoyl spermidine + NADPH + O2 = monocoumaroyl dicaffeoyl spermidine + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849857", "l": "KLK5 cleaves and activates CELA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508163", "l": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17634", "l": "a beta-D-glucuronoside + H2O => an alcohol + D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39666", "l": "a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004579", "l": "dolichyl-diphosphooligosaccharide-protein glycotransferase activity", "d": ["Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755304", "l": "MUL1 ubiquitinates UBXN7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102331", "l": "heptadecanoyl-[acp] elongase/decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA + 3 H+ + a heptodecanoyl-[acp] = octadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016165", "l": "linoleate 13S-lipoxygenase activity", "d": ["Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389961", "l": "ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55727", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78156", "l": "RNA(n)-3'-guanine ribonucleotide => 2',3'-cyclophospho-GMP + RNA(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166038", "l": "GPI-bound CD14 binds LPS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784204", "l": "JAKs bind OSMR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787566", "l": "PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63920", "l": "octadecanoyl-CoA + sphinga-4E,14Z-dienine = CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43091", "l": "5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine <=> 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18269", "l": "ethyl (S)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.280", "l": "\"(S)-3-hydroxyacid-ester dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69316", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate = allyl thiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033842", "l": "N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8963915", "l": "1,25(OH)2D binds VDR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.042693372152272", "identifiers": [{"i": "GO:0019842", "l": "vitamin binding", "d": ["Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296462", "l": "Defective CUBN does not transport GIF:Cbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0005365", "l": "myo-inositol transmembrane transporter activity", "d": ["Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173725", "l": "C9 binds C5b:C6:C7:C8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62439", "l": "L-lyxonate <=> 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047881", "l": "estradiol 17-alpha-dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39935", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17036", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) <=> biphenyl-2,3-diol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013021", "l": "GDIs block activation of RHOB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19928", "l": "D-ribitol 5-phosphate + NAD(+) <=> D-ribulose 5-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34014", "l": "5-dehydroepisterol + 2 H2O + NADP(+) <=> ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467775", "l": "Autocleavage of ESPL1 (Separase) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47665", "l": "H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) => 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66488", "l": "quillate + UDP-alpha-D-glucose = quillaic acid 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71690", "l": "glycyl-L-aspartate(out) + 2 H(+)(out) <=> glycyl-L-aspartate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19964", "l": "a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate <=> a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015327", "l": "cystine:glutamate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32266", "l": "4-aminobutanoate + pyruvate <=> L-alanine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67075", "l": "a very long-chain fatty acyl-CoA + H2O <=> a very long-chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23925", "l": "pppGp(2'-5')A => 2',3'-cGAMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57207", "l": "glyoxal + L-lysyl-[protein] <=> N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.9.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033791", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity", "d": ["Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912734", "l": "CBL:CRKL binds RAPGEF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14140", "l": "3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine <=> 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.41", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730841", "l": "Phosphorylation and activation of VAV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64414", "l": "n H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) => n H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3341294", "l": "Superoxide reduces cytochrome c (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902387", "l": "ceramide 1-phosphate binding", "d": ["Binding to ceramide 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50934", "l": "(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate => (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34743", "l": "15-methylhexadecasphinganine 1-phosphate = 13-methyltetradecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62404", "l": "(R)-2-hydroxyhexadecanoate + O2 = CO2 + H2O + pentadecanoate", "d": [], "t": []}, {"i": "EC:1.14.18.12", "l": "\"2-hydroxy fatty acid dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210430", "l": "Release of L-Glutamate at the synapse (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327733", "l": "FN1 binds Collagen types I-V, VII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9695949", "l": "SPHK2 phosphorylates sphingoid (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5617828", "l": "TRIP11:IFT20 dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781899", "l": "USP13 binds SIAH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140769", "l": "factor VII -> factor VIIa (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26089", "l": "(4S)-limonene + H(+) + NADH + O2 = H2O + limonene 1,2-epoxide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28752", "l": "sn-glycerol 3-phosphate + ubiquinone-8 => dihydroxyacetone phosphate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0035596", "l": "methylthiotransferase activity", "d": ["Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15835", "l": "4-hydroxybenzaldehyde + CO2 + H2O2 => (S)-4-hydroxymandelate + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72131", "l": "agmatine(out) = agmatine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66180", "l": "(4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside(in) + ATP + H2O = (4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082391", "l": "Trimerization of HSF1 in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62411", "l": "3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine <=> 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950362", "l": "EBI3:CANX binds IL12A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16143", "l": "3''-deamino-3''-oxonicotianamine + H(+) + NADH => 2'-deoxymugineate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428123", "l": "KDSR reduces 3-ketosphingoid (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191654", "l": "c-src associates with Cx43 in gap junctions (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162193", "l": "COQ3 methylates DHDB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.254", "l": "\"N-terminal methionine N(alpha)-acetyltransferase NatB\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14204", "l": "D-lyxose <=> D-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54091", "l": "3,4-dihydroxyphenylacetate + H(+) + NADH + O2 <=> 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807826", "l": "LDHAL6B reduces PYR to LACT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879942", "l": "The receptor is activated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050054", "l": "lignostilbene alpha beta-dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24930", "l": "H2O + L-cystine <=> NH4(+) + pyruvate + S-sulfanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42350", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70997", "l": "SUCLG1/A2 cleaves succinyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77204", "l": "3'-phosphoadenylyl sulfate + deoxycholate => 3alpha-sulfodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53668", "l": "(2E,6E)-farnesyl diphosphate = (1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.165", "l": "\"(1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17320", "l": "chlorophyllide a + H(+) + phytyl diphosphate <=> chlorophyll a + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052809", "l": "acharan sulfate lyase activity", "d": ["Catalysis of the cleavage of a carbon-oxygen bond in acharan sulfate, a glycosaminoglycan with a uniformly repeating disaccharide structure of alpha-D-N-acetylglucosaminyl-2-O-sulfo-alpha-L-iduronic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211239", "l": "Association of DFF40 with chromatin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69198", "l": "ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate => ATP + L-glutamate + L-glutamyl-[beta-tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0017024", "l": "myosin I binding", "d": ["Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836256", "l": "RSV sG binds TLR2:TLR6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6805061", "l": "CK2 binds FACT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49633", "l": "(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate => (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339535", "l": "CPTP transports C1P from plasma membrane to Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0016696", "l": "oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP."], "t": []}, {"i": "EC:1.12.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167288", "l": "TFIIS-mediated recovery of HIV-1 elongation from arrest (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9646468", "l": "mTORC1 binds RHEB:GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48984", "l": "(2,4-dichlorophenoxy)acetate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + glyoxylate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20177", "l": "pyridoxine + UDP-alpha-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.160", "l": "\"pyridoxine 5'-O-beta-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990446", "l": "U1 snRNP binding", "d": ["Binding to a U1 small nuclear ribonucleoprotein particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.17", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22579", "l": "an N-acyl-L-homoserine lactone + H2O <=> an N-acyl-L-homoserine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102730", "l": "cathasterone hydroxylase activity", "d": ["Catalysis of the reaction: cathasterone + O2 + a reduced electron acceptor = teasterone + H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69871", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68509", "l": "(2E,6E)-farnesyl diphosphate => (Z)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140952", "l": "histone H3K27 dimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl27-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl27-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029456", "l": "RAC1 and CDC42 activate PAK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61697", "l": "ATP + glycine + holo-[peptidyl-carrier protein] => AMP + diphosphate + glycyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46107", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> corticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25033", "l": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.300", "l": "\"NADP-retinol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35545", "l": "3-hydroxypyruvate + phosphate => 3-phosphooxypyruvate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297333", "l": "Association of Acrosin Heavy and Light Chain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810724", "l": "PI3 binds the bacterial surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24971", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> H2O + 2 oxidized [adrenodoxin] + secalciferol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37686", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA <=> 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72579", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O = (22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16634", "l": "guanosine(34) in tRNA + queuine => guanine + queuosine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55662", "l": "2 A + echinenone + 3 H2O => 2 AH2 + all-trans-beta-carotene + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12011", "l": "[G-protein-coupled receptor] + ATP <=> [G-protein-coupled receptor]-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45203", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[corrinoid Fe-S protein] <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[corrinoid Fe-S protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42409", "l": "(2R)-2-phosphoglycerate + ATP => (2R)-2,3-bisphosphoglycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24945", "l": "(4S)-4-hydroxy-L-glutamate + H(+) + NADPH => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34449", "l": "dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH => dTDP-6-deoxy-beta-L-talose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139899", "l": "Sequestration of BAD protein by 14-3-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76664", "l": "H2O + NADP(+) + pentanal => 2 H(+) + NADPH + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44795", "l": "2-demethylmenaquinol-12 + S-adenosyl-L-methionine <=> H(+) + menaquinol-12 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008864", "l": "formyltetrahydrofolate deformylase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141409", "l": "Mad1 binds kinetochore (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19239", "l": "4-carboxymethyl-3-methylbut-2-en-1,4-olide => 4-carboxymethyl-4-methylbut-2-en-1,4-olide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28415", "l": "gamma-L-glutamylputrescine + H2O + O2 => 4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34133", "l": "cannabinerolate + diphosphate => neryl diphosphate + olivetolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0019763", "l": "immunoglobulin receptor activity", "d": ["Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1467466", "l": "ABCA4 mediates atRAL transport (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948757", "l": "AKT phosphorylates MKRN1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034348", "l": "type III interferon receptor activity", "d": ["Combining with a type III interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Interferon lambda is the only member of the type III interferon found so far."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67497", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O => 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17307", "l": "dimethylamine + L-citrulline => H2O + N(omega),N(omega)-dimethyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849906", "l": "SALM1 binds NMDA receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48433", "l": "ATP + N(6)-D-ribulosyl-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44663", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine <=> 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010313", "l": "phytochrome binding", "d": ["Binding to a phytochrome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209815", "l": "Tyrosine is monoiodinated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68963", "l": "7,8-dihydroxycoumarin + S-adenosyl-L-methionine <=> 7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39428", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH => (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71461", "l": "L-Leu-L-Met-NH2 + substance P(1-9) => H2O + substance P", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38037", "l": "(4Z)-2-oxohept-4-enedioate => (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607747", "l": "TRAF6 binds MALT1 oligomers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54739", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050591", "l": "quinine 3-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + quinine = 3-hydroxyquinine + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49219", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O <=> 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434084", "l": "p-IRAK2- TRAF6 dissociates from the activated chTLR complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52842", "l": "1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP => UDP-alpha-D-glucose + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18474", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50083", "l": "ATP + H2O + taurodeoxycholate(in) <=> ADP + H(+) + phosphate + taurodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39247", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA = (2E,11Z)-eicosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28703", "l": "Cu(2+)(in) = Cu(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8978926", "l": "MYBL2 gene expression is inhibited by RBL1 and RBL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25457", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-humulene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11735", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B <=> H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51146", "l": "(10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29079", "l": "(R)-lactate + ubiquinone-8 = pyruvate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66669", "l": "5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] => 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204863", "l": "Interaction of Tie2 with Ang2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380930", "l": "Phosphorylated AMPK binds AMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10114", "l": "H2O + L,L-cystathionine => L-homocysteine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35081", "l": "doxorubicin(out) => doxorubicin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629918", "l": "NEIL1 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445700", "l": "Myosin Binds ATP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61433", "l": "(R)-8-oxocitronellyl enol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47145", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26049", "l": "glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654569", "l": "Activated FGFR1 binds FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12906", "l": "alpha-D-mannose 1-phosphate + GDP + H(+) => GDP-alpha-D-mannose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244614", "l": "cGAS produces cyclic GMP-AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70982", "l": "FH tetramer hydrates fumarate to L-malate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63533", "l": "angiotensin I + H2O => angiotensin-(1-9) + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614591", "l": "Excess cysteine yields lanthionine and H2S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61689", "l": "ATP + holo-[peptidyl-carrier protein] + L-threonine => AMP + diphosphate + L-threonyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65163", "l": "benzoyl-CoA + hexan-2-ol <=> CoA + hexan-2-yl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.69", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782311", "l": "ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149440", "l": "Transport of VPU to Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34914", "l": "D-methionine(in) <=> D-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15985", "l": "formate + NAD(+) = CO2 + NADH", "d": [], "t": []}, {"i": "EC:1.17.1.9", "l": "\"formate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48006", "l": "3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O => 1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533950", "l": "Fibronectin degradation by MMP14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132221", "l": "C5b:C6:C7:C8 and C9 bind to form membrane attack complex (MAC) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43386", "l": "ADP + H(+) + N(omega)-phospho-L-arginyl-[protein] => ATP + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624131", "l": "UNC119B binds myristoylated proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-450348", "l": "Activated human JNKs migrate to nucleoplasm (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15871", "l": "D-glutamate + pyruvate => 2-oxoglutarate + D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070051", "l": "fibrinogen binding", "d": ["Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36294", "l": "3-methylxanthine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29758", "l": "(R)-lipoate(in) <=> (R)-lipoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785898", "l": "IL4R binds JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72616", "l": "H(+)(out) + L-alanyl-L-valine(out) => H(+)(in) + L-alanyl-L-valine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858435", "l": "TSPAN7 binds PICK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10356", "l": "3alpha-hydroxy-5beta-androstan-17-one + NAD(+) = 5beta-androstane-3,17-dione + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.152", "l": "\"3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55541", "l": "40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] => 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.53", "l": "\"3alpha(or 20beta)-hydroxysteroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875623", "l": "SLC25A18,22 import L-Glu, H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012671", "l": "p-STAT5 binds CISH, SOCS1 and SOCS2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417898", "l": "P2Y4 receptor can bind to UTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30368", "l": "adenosylcob(III)alamin 5'-phosphate + H2O => adenosylcob(III)alamin + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807008", "l": "PTPRJ dephosphorylates MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24268", "l": "2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.40", "l": "\"2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045435", "l": "lycopene epsilon cyclase activity", "d": ["Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74179", "l": "a secondary alkyl amine + H2O + NADP(+) = a ketone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36098", "l": "S-adenosyl-L-methionine + salicylate <=> methyl salicylate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70574", "l": "D-glucose(out) + Na(+)(out) <=> D-glucose(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051992", "l": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine + di-trans,poly-cis-undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75448", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 => (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692738", "l": "HRH2 binds HRH2 antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18392", "l": "alpha-D-xylose 1-phosphate + H(+) + UTP <=> diphosphate + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140684", "l": "histone H3K9me2/H3K9me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601843", "l": "Defective CYP17A1 does not 17-hydroxylate PREG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66441", "l": "butan-2-one + NADP(+) => but-3-en-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607722", "l": "Active NIK phosphorylates IKKA dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606564", "l": "GALC hydrolyzes GalCer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29312", "l": "FMNH2 + O2 + sulfoacetate => FMN + glyoxylate + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41415", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9828175", "l": "Formation of the NSL complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72274", "l": "formate(out) + oxalate(in) <=> formate(in) + oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35572", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] => (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41534", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10214", "l": "5-oxopentanoate + L-glutamate => 2-oxoglutarate + 5-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31590", "l": "FMNH2 + NADH + O2 + uracil <=> (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662747", "l": "iRHOM2 transports ADAM17 from ER to the Golgi-network (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211924", "l": "CYP4B1 12-hydroxylates ARA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15689", "l": "H(+) + L-2,4-diaminobutanoate = CO2 + propane-1,3-diamine", "d": [], "t": []}, {"i": "EC:4.1.1.86", "l": "\"diaminobutyrate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70294", "l": "3-(2-aminophenyl)-3-oxopropanal <=> H2O + quinolin-4-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211983", "l": "CYP2J2 oxidises ARA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69235", "l": "(Z)-3-hydroxypropyl glucosinolate + H2O <=> (Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905574", "l": "ganglioside GM2 binding", "d": ["Binding to ganglioside GM2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73850", "l": "17alpha-hydroxywithaferin A + UDP-alpha-D-glucose <=> 17alpha-sitoindoside IX + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034841", "l": "mentha-1,3-dione-CoA ligase activity", "d": ["Catalysis of the reaction: mentha-1,3-dione + CoASH = 3,7-dimethyl-5-oxo-octyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018747", "l": "RHOQ GEFs activate RHOQ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11654", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444047", "l": "Receptor FFAR3 binds carboxylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018768", "l": "RHOU auto-activates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333671", "l": "CLCAs self cleave (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014454", "l": "RHOG translocates to the ER membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13330", "l": "A + a 3-oxosteroid => a 3-oxo-Delta(1)-steroid + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52539", "l": "adenosine + dGTP <=> AMP + dGDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29776", "l": "alpha-D-ribose 1-phosphate + ATP => ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668023", "l": "TPST1,2 transfer SO4(2-) from PAPS to FVIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030752", "l": "5-hydroxyfuranocoumarin 5-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734540", "l": "ACLY tetramer binds ETC-1002-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070975", "l": "FHA domain binding", "d": ["Binding to a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33481", "l": "CoA + lanosteryl ester => an acyl-CoA + lanosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33294", "l": "L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9670673", "l": "FIX is secreted (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35282", "l": "acetyl-CoA + hexadecanoyl-CoA <=> 3-oxooctadecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74231", "l": "H2O + L-threonyl-tRNA(Val) = L-threonine + tRNA(Val)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46178", "l": "2-methylpropanoyl-CoA + AMP + diphosphate => 2-methylpropanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9853512", "l": "DLST transfers succinyl to CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936851", "l": "AHRR binds ARNT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168883", "l": "Binding of NS1 to poly(A)-binding protein II (PABII) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70756", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675656", "l": "EDA:EDAR binds EDARADD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68280", "l": "L-seryl-[protein] + pentanoyl-CoA = CoA + O-pentanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17276", "l": "(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) <=> 4-hydroxyphenylacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.24", "l": "\"1,4-alpha-glucan 6-alpha-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35678", "l": "H(+) + L-serine + tetradecanoyl-CoA <=> 3-oxohexadecasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19784", "l": "2-oxoglutarate + 3,5-diiodo-L-tyrosine <=> 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65873", "l": "1,17beta-dihydroxyandrostan-3-one + A => 17beta-hydroxyandrostan-1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79025", "l": "alpha-D-Man-(1->6)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.242", "l": "\"Kdo2-lipid IVA palmitoleoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69425", "l": "2-hydroxyisobutanoyl-CoA => acetone + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033996", "l": "levan fructotransferase (DFA-IV-forming) activity", "d": ["Catalysis of the reaction: beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)]n-D-fructofuranoside = beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)](n-1)-D-fructofuranoside + di-beta-D-fructofuranose 2,6':2',6-dianhydride. This reaction is the production of di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12124", "l": "4-coumaroyl-CoA + shikimate = CoA + trans-4-coumaroylshikimate", "d": [], "t": []}, {"i": "EC:2.3.1.133", "l": "\"shikimate O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20423", "l": "D-glucose + D-glucose 6-phosphate => alpha-maltose 6'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44917", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH => (3E)-decenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24436", "l": "H2 + methanophenazine = dihydromethanophenazine", "d": [], "t": []}, {"i": "EC:1.12.98.3", "l": "\"Methanosarcina-phenazine hydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848023", "l": "Activated PTK6 binds STAP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35171", "l": "H(+)(out) + novobiocin(in) = H(+)(in) + novobiocin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113454", "l": "RNA Polymerase III Termination and release of transcribed RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166753", "l": "Conversion of C4 into C4a and C4b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212642", "l": "L-Glutamine transport into neurons (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63521", "l": "2-isopropylphenol + H(+) + NADH + O2 => 3-isopropylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63970", "l": "atromentin + 2 H2O => 2 3-(4-hydroxyphenyl)pyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.95", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74916", "l": "a (2E)-enoyl fatty acid + ATP + H(+) => a (2E)-2-fatty-enoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.13", "l": "\"glutathione gamma-glutamate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018758", "l": "RHOH binds effectors at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33587", "l": "acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate = CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": [], "t": []}, {"i": "EC:2.3.1.201", "l": "\"UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32548", "l": "(2E)-geranyl diphosphate => (1R,5R)-sabinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62209", "l": "3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] => 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52383", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27369", "l": "acetoin + CoA + NAD(+) = acetaldehyde + acetyl-CoA + H(+) + NADH", "d": [], "t": []}, {"i": "EC:2.3.1.190", "l": "\"acetoin dehydrogenase system\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58766", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021609", "l": "ESR-associated SRC autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41198", "l": "1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59636", "l": "D-xylotriose + O2 = D-xylotriono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60243", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43475", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21608", "l": "isoliquiritigenin + S-adenosyl-L-methionine = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.154", "l": "\"isoliquiritigenin 2'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25233", "l": "N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate", "d": [], "t": []}, {"i": "EC:5.1.3.24", "l": "\"N-acetylneuraminate epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15074", "l": "3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O => D-glucuronate + N(2),6-disulfo-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29523", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.131", "l": "\"GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169307", "l": "Monoubiquitination of N-myristoyl GAG (P12493) protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781905", "l": "ZRANB1 binds APC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33082", "l": "6-amino-6-deoxyfutalosine + H2O <=> adenine + dehypoxanthine futalosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015439", "l": "ABC-type heme transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34780", "l": "a 3alpha-hydroxysteroid + NAD(+) => a 3-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685230", "l": "CHEK1 phosphorylates RAD51 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35219", "l": "8-oxo-dADP + H2O = 8-oxo-dAMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77678", "l": "a globoside GalGb4Cer (d18:1(4E)) + H2O <=> an N-acylsphing-4-enine + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613497", "l": "Unwinding DNA for the nascent transcript (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66588", "l": "a cytidine in 26S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54447", "l": "a (2R,3S,4S)-leucoanthocyanidin + NADP(+) <=> a (2R,3R)-dihydroflavonol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683648", "l": "Spike trimer glycoside chains are extended (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5604929", "l": "Activated protein C binds Protein S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78282", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + somaliensene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54099", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933523", "l": "Dimerzation of procaspase-8, procaspase-10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114254", "l": "CYCS binds to APAF1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45466", "l": "(5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30836", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12738", "l": "5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine => [PrdC protein]-L-selenocysteine/L-cysteine + D-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72404", "l": "2-oxoglutarate(out) + urate(in) => 2-oxoglutarate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59710", "l": "D-maltotrionate + H(+) => D-maltotriono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43425", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25890", "l": "H(+) + 2 H2O + phosphate + quinolinate => dihydroxyacetone phosphate + iminosuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44904", "l": "alpha-D-glucose 6-phosphate + H2O = alpha-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8847537", "l": "RAB43:GTP binds USP8NL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395412", "l": "Phosphorylation of SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140683", "l": "histone H3K9me/H3K9me2 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a di or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68454", "l": "4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone => all-trans-10'-apo-beta-carotenal + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102658", "l": "2-oxo-5-methylthiopentanoate aminotransferase activity", "d": ["Catalysis of the reaction: 5-methylthio-2-oxopentanoate + a standard alpha amino acid = L-homomethionine + a 2-oxo carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141106", "l": "tRNA methyltransferase activator activity", "d": ["Binds to and increases the activity of a methyltransferase."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392749", "l": "Transport of L1 into endosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55150", "l": "a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH => a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78628", "l": "L-cysteine + S-sulfanyl-L-cysteine => L-alanine + S-disulfanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72216", "l": "2 hydrogencarbonate(out) + Na(+)(out) => 2 hydrogencarbonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48719", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 13-oxo-(9Z,11E)-octadecadienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70520", "l": "(R)-octopamine + S-adenosyl-L-methionine => (R)-synephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170159", "l": "Translocation of Cdc25 to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63489", "l": "9,10-phenanthroquinone + H(+) + NADPH => NADP(+) + phenanthrene-9,10-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674385", "l": "p-T,Y MAPKs dimerize (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75567", "l": "acetyl-CoA + cyathatriol = 11-O-acetylcyathatriol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59463", "l": "hexadecan-1-ol + NADP(+) <=> H(+) + hexadecanal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13036", "l": "aldehydo-D-galactose 6-phosphate <=> keto-D-tagatose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977301", "l": "Histidine is decarboxylated to histamine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20310", "l": "2 H2O2 => 2 H2O + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41324", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28983", "l": "nitrite(in) = nitrite(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66974", "l": "alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+) => alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70182", "l": "2 D-maltotetraose <=> alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25519", "l": "an acyl-CoA + tropine <=> CoA + H(+) + O-acyltropine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0004911", "l": "interleukin-2 receptor activity", "d": ["Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51887", "l": "L-proline betaine <=> D-proline betaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71548", "l": "5-phosphomethyl-dUMP in DNA + glycine => 5-N(alpha)-glycyl-dTMP in DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22578", "l": "an N-acyl-L-homoserine + H(+) => an N-acyl-L-homoserine lactone + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.2.19", "l": "\"streptothricin hydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68425", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + O2 => (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17731", "l": "a cholesterol ester + CoA => an acyl-CoA + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71386", "l": "L-asparagine(in) + Na(+)(in) <=> L-asparagine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76955", "l": "2-methylbutanamine + H2O + NAD(+) = 2-methylbutanal + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879907", "l": "Tyrosine kinases phosphorylate the receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44981", "l": "(R)-carnitine + butanoyl-CoA => CoA + O-butanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35479", "l": "(1'S,5'R)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754964", "l": "ADA deamidates RBV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005143", "l": "interleukin-12 receptor binding", "d": ["Binding to an interleukin-12 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809309", "l": "MTMR6 binds MTMR9 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79008", "l": "3-amino-4-hydroxybenzoate + ATP + H(+) + nitrite => 3-diazo-4-hydroxybenzoate + AMP + diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174438", "l": "Formation of the Flap Intermediate on the C-strand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18546", "l": "2-dehydro-3-deoxy-L-arabinonate => glycolaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37860", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA => 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67493", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69393", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28467", "l": "pyridoxamine(in) => pyridoxamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35031", "l": "L-serine(in) = L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446322", "l": "PARVA associates with Paxillin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54001", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29213", "l": "H(+)(in) + inosine(out) => H(+)(out) + inosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50755", "l": "2 naphthalene-1,2,4,8-tetrol + O2 <=> 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72544", "l": "2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out) => 2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42459", "l": "4alpha-methylzymosterol <=> zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788867", "l": "FN3K phosphorylates ketosamines (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27988", "l": "H(+) + methylglyoxal + NADPH => hydroxyacetone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34967", "l": "sn-glycerol 3-phosphate(in) = sn-glycerol 3-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42505", "l": "2-oxoglutarate + N(6)-acetyl-L-lysine => 6-acetamido-2-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74723", "l": "Endosome acidification (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18133", "l": "ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.4", "l": "\"sulfate adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60787", "l": "2-oxoglutarate + gibberellin A24 + O2 <=> CO2 + gibberellin A25 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75803", "l": "butanoate(out) + Na(+)(out) = butanoate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033854", "l": "glutamate-prephenate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48673", "l": "20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034452", "l": "dynactin binding", "d": ["Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33596", "l": "(4R)-hydroxysphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22867", "l": "L-lysine <=> D-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67301", "l": "(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one => 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637635", "l": "esxA binds B2M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42123", "l": "17beta-hydroxy-5alpha-androstan-3-one + NADP(+) <=> 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016524", "l": "latrotoxin receptor activity", "d": ["Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202328", "l": "Translocation of PKC theta to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74040", "l": "D-alanine(out) + L-alanine(in) => D-alanine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0009033", "l": "trimethylamine-N-oxide reductase activity", "d": ["Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0034483", "l": "heparan sulfate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736984", "l": "p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 binds MYC gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50117", "l": "eicosanoyl-CoA + taurine => CoA + H(+) + N-eicosanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22891", "l": "(R)-methylmalonyl-CoA <=> succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24521", "l": "H2O + L-saccharopine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13164", "l": "L-threonine + NAD(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38055", "l": "CTP + phytol = CDP + H(+) + phytyl phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.182", "l": "\"phytol kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609689", "l": "HCMV Binds to the Host Cell via heparan sulfate proteoglycans (HSPG) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36079", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65830", "l": "diphosphate + nerol => H2O + neryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106437", "l": "protein-glutamic acid ligase activity, initiating", "d": ["Catalytic reaction: ATP + L-glutamate + L-glutamyl-[protein] = ADP + H+ + L-gamma-glutamyl-L-glutamyl-[protein] + phosphate."], "t": []}, {"i": "RHEA:60144", "l": "ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5604975", "l": "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BIL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74163", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879222", "l": "MDP:NLRP1 binds ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.66", "l": "\"XTP/dITP diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60416", "l": "diglucosyl-enterobactin + H2O = H(+) + N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9032798", "l": "DOCK3 activates RAC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75235", "l": "L-fucono-1,5-lactone = L-fucono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263492", "l": "Defective HGSNAT does not acetylate Heparan chain(1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213201", "l": "Formation of collagen fibres (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42383", "l": "2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O <=> 2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27440", "l": "2 glutathione amide + H2O2 <=> glutathione amide disulfide + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140948", "l": "histone H3K9 monomethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939204", "l": "ESTG binds ESR1:chaperone complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76246", "l": "a glycyl-glycyl-[protein] + H2O <=> [protein]-C-terminal glycine + N-terminal glycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071968", "l": "lipid A-core heptosyltransferase activity", "d": ["Catalysis of the reaction: galactosyl-glucosyl3-heptosyl3-KDO2-lipid A-bisphosphate + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53930", "l": "a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine => a tertiary amine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51578", "l": "H(+) + phlorizin + UDP => phloretin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.12", "l": "\"phosphoglycerate mutase (2,3-diphosphoglycerate-independent)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48392", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose = a neolactoside IV(3)-alpha-NeuNAc,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32160", "l": "AH2 + epoxyqueuosine(34) in tRNA => A + H2O + queuosine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74645", "l": "CMP-N-acetyl-beta-neuraminate(out) + UMP(in) => CMP-N-acetyl-beta-neuraminate(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786155", "l": "POLN binds ICL-DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102607", "l": "3beta-hydroxy-12,15-cassadiene-11-one 2-hydroxylase activity", "d": ["Catalysis of the reaction: 3beta-hydroxy-12,15-cassadiene-11-one + NADPH + O2 + H+ = 2beta,3beta-dihydroxy-12,15-cassadiene-11-one + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928608", "l": "LIMK phosphorylates CFL1, inactivating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692408", "l": "NPR2 binds NPPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372910", "l": "pyruvate + NADH + H+ <=> lactate + NAD+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72671", "l": "6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2 = 1,6-dihydroxyphenazine + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473584", "l": "Collagen type III degradation by MMP15 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70975", "l": "3-sulfino-L-alanine(out) + L-aspartate(in) = 3-sulfino-L-alanine(in) + L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0016695", "l": "oxidoreductase activity, acting on hydrogen as donor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor."], "t": []}, {"i": "EC:1.12.-.-", "l": "\"Acting on hydrogen as donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726621", "l": "PGR binds PGR antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23483", "l": "2-methylene-3-methylsuccinate <=> dimethylmaleate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32738", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine <=> 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56902", "l": "a globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP => a globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174171", "l": "Association of Cyclin A with the APC/C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55393", "l": "an adenosine in mRNA + S-adenosyl-L-methionine => an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45847", "l": "(3R)-hydroxyoctanoyl-CoA + NADP(+) <=> 3-oxooctanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30052", "l": "fluoroacetate + H2O => fluoride + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112429", "l": "Formation of FACT complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39445", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63685", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + ATP => (4R,5S)-dethiobiotin + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24774", "l": "chlorophyllide b + H(+) + NADPH => 7(1)-hydroxychlorophyllide a + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13333", "l": "beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 2-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.54", "l": "\"fructose-2,6-bisphosphate 6-phosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964525", "l": "RBL1 gene expression is repressed by the DREAM complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975139", "l": "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23402", "l": "5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+) => 7,8-dihydroxykynurenate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42584", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41966", "l": "(2E)-butenoyl-CoA + H2O2 => butanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34340", "l": "(22R)-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (20R,22R)-20,22-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27782", "l": "4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64346", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+) => 4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35264", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68360", "l": "L-xylono-1,4-lactone + O2 = dehydro-L-arabinono-1,4-lactone + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33599", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29399", "l": "H2O + ITP = diphosphate + H(+) + IMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15254", "l": "cis-aconitate + H(+) => CO2 + itaconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19091", "l": "H(+) + precorrin-1 + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uroporphyrinogen III", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940134", "l": "FOLR2 binds FOLA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18066", "l": "ATP + H2O + phosphonate(out) => ADP + H(+) + phosphate + phosphonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801101", "l": "RABGGTA binds RABGGTB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56741", "l": "a globoside Gb3Cer + UDP-alpha-D-galactose => a globoside GalGb3Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23126", "l": "CO2 + D-ribulose 1,5-bisphosphate + H2O => 2 (2R)-3-phosphoglycerate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74779", "l": "laricitrin + S-adenosyl-L-methionine = 3,3'-O-dimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74116", "l": "an anthocyanidin + UDP-alpha-D-galactose => an anthocyanidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65353", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20116", "l": "beta-D-glucose 1-phosphate <=> beta-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.4.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211247", "l": "Cleavage of DNA by DFF40 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12725", "l": "D-iditol + NAD(+) = H(+) + keto-D-sorbose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39371", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62168", "l": "H2O + N,N'-diacetylchitobiose = acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine", "d": [], "t": []}, {"i": "EC:3.5.1.136", "l": "\"N,N'-diacetylchitobiose non-reducing end deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204485", "l": "Basigin binds CyPA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17471", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein] => a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52870", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP => 17alpha-estradiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76834", "l": "H2O + hexylamine + NAD(+) <=> H(+) + hexanal + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25268", "l": "2-phenylethylamine + H2O + O2 <=> 2-phenylacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59825", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate => L-glutamate + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677050", "l": "Formation of the GCN5-ATAC complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56503", "l": "(R)-3,5-bisphosphomevalonate + H(+) <=> CO2 + isopentenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875443", "l": "USP8 deubiquitinates LRIG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20770", "l": "CO2 + phosphonoacetaldehyde => 3-phosphonopyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49284", "l": "8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP = CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.90", "l": "\"8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380782", "l": "STAT binds to the active receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44348", "l": "ATP + L-isoleucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate = ADP + dapdiamide B + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40785", "l": "CoA + docosanoate + H(+) => docosanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23477", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9844015", "l": "MPHOSPH8 (MPP8) in HUSH complex binds histone H3 trimethyl-lysine 9 (H3K9me3) in L1HS,L1PA2,3 heterochromatin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24168", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3204303", "l": "MRE11 binds cytosolic DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37712", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA => 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749609", "l": "BCHE hydrolyzes ASA- (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56781", "l": "(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] => (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0015288", "l": "porin activity", "d": ["Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664867", "l": "NBR1 binds MAP1LC3B (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.-.-.-", "l": "\"Translocases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610195", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2D (GRIN2D) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72622", "l": "2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0015459", "l": "potassium channel regulator activity", "d": ["Binds to and modulates the activity of a potassium channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37918", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55540", "l": "40 ATP + 40 H2O + N2 + 12 reduced [2Fe-2S]-[ferredoxin] = 40 ADP + 26 H(+) + 3 H2 + 2 NH4(+) + 12 oxidized [2Fe-2S]-[ferredoxin] + 40 phosphate", "d": [], "t": []}, {"i": "EC:1.18.6.2", "l": "\"vanadium-dependent nitrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53929", "l": "a tertiary amine + S-adenosyl-L-methionine => a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31767", "l": "2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}, {"i": "EC:2.6.1.92", "l": "\"UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.126", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602004", "l": "Defective CYP24A1 does not 24-hydroxylate CALTOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50495", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73715", "l": "ATP(in) + dATP(out) = ATP(out) + dATP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034016", "l": "NTF3 binds NTRK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814094", "l": "ARL1:GTP binds ARFIP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372819", "l": "PCK2 phosphorylates OA to yield PEP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9718379", "l": "GNRHR binds chemical antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52058", "l": "12-hydroxyoctadecanoate + H(+) + hexadecanoate => 12-hexadecanoyloxy-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76483", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphing-4-enine = 2 Fe(III)-[cytochrome b5] + 2 H2O + sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78919", "l": "a medium-chain (3S)-3-hydroxyacyl-CoA + NAD(+) = a medium-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24838", "l": "5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68772", "l": "(2Z,6Z)-farnesyl diphosphate = diphosphate + germacrene C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18629", "l": "ATP + NAD(+) = ADP + H(+) + NADP(+)", "d": [], "t": []}, {"i": "EC:2.7.1.23", "l": "\"NAD(+) kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0050542", "l": "icosanoid binding", "d": ["Binding to icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21791", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677050", "l": "Formation of the GCN5-ATAC complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215251", "l": "TP53INP1 and HIPK2 bind TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928614", "l": "EFNB:GRB4 binds GIT1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64764", "l": "S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine = 2-aminoprop-2-enoate + 3-methyl-3-sulfanylhexan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018746", "l": "phenanthrene-3,4-epoxide hydrolase activity", "d": ["Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48641", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) => 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28203", "l": "2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate => 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5662466", "l": "XYLB phosphorylates D-xylulose (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17639", "l": "hop-22(29)-ene => squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878054", "l": "HIPK2 phosphorylates RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798528", "l": "S100A8:S100A9 binds Mn2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71142", "l": "acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH <=> 3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951727", "l": "cAMP binds PKA tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.012360833342299", "identifiers": [{"i": "GO:0016278", "l": "lysine N-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937814", "l": "RUNX3 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665727", "l": "FMNL2 binds CDC42:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46218", "l": "3beta-hydroxypregn-4-ene-20-one + NADP(+) => H(+) + NADPH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420117", "l": "VEGFR2 autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31357", "l": "formaldehyde + H2O + methanethiol + NAD(+) => dimethyl sulfide + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373724", "l": "Nephrin binds NCK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177920", "l": "Binding of GRB2 to GAB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78993", "l": "a 3-alkylbut-(2E)-enoyl-[ACP] + CO2 => a 4-carboxy-3-alkylbut-(2E)-enoyl-[ACP] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14457", "l": "glyoxylate + H2O + pentanoyl-CoA = 3-propylmalate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.12", "l": "\"3-propylmalate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696271", "l": "RND1 binds effectors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865425", "l": "RUNX2 binds CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11657", "l": "ATP + holo-[peptidyl-carrier protein] + L-proline => AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.31.-", "l": "\"Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042888", "l": "molybdenum ion transmembrane transporter activity", "d": ["Enables the transfer of molybdenum (Mo) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204798", "l": "Interaction of Tie2 and p85 of PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51367", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine <=> CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63765", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202443", "l": "Oligomerization of CARMA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55202", "l": "2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine => 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74197", "l": "(5Z)-3-(3,4-dihydroxyphenyl)-5-[(3,4-dihydroxyphenyl)methylidene]-5-oxo-2,5-dihydrofuran-3-olate => aspulvinone E + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49716", "l": "3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 = 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.223", "l": "\"3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein] 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66427", "l": "ATP + H2O + leukotriene B4(in) <=> ADP + H(+) + leukotriene B4(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49121", "l": "H(+) + NADPH + O2 + protoviolaceinate => H2O + NADP(+) + violaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009675", "l": "high-affinity sulfate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21286", "l": "all-trans-retinal + H(+) + NADH => all-trans-retinol + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63881", "l": "2 Fe(III)-[cytochrome c] + H2O + thiocyanate => cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018580", "l": "nitronate monooxygenase activity", "d": ["Catalysis of the reaction: ethylnitronate + O2 = acetaldehyde + nitrite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483186", "l": "PC is converted to PS by PTDSS1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432909", "l": "Interaction of Plectin with Integrin beta 4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49151", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44003", "l": "2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 <=> 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869683", "l": "oxPL binds LBP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23702", "l": "(6R)-10-formyltetrahydrofolate + H(+) => (6R)-5,10-methenyltetrahydrofolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005169", "l": "neurotrophin TRKB receptor binding", "d": ["Binding to a neurotrophin TRKB receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009916", "l": "alternative oxidase activity", "d": ["Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705926", "l": "AR binds AR agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193964", "l": "CYP21A2 21-hydroxylates PROG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71664", "l": "a menaquinone + 2 H(+)(out) + succinate => a menaquinol + fumarate + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018800", "l": "5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity", "d": ["Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692134", "l": "Expression of FGF9 in testis differentiation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40541", "l": "H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27830", "l": "neryl diphosphate = beta-phellandrene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.51", "l": "\"beta-phellandrene synthase (neryl-diphosphate-cyclizing)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58126", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde => (19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66827", "l": "2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16029", "l": "3-guanidinopropanoate + H2O = beta-alanine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66753", "l": "(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O => (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69624", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57091", "l": "an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18981", "l": "(R)-pantolactone + NADP(+) = 2-dehydropantolactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202222", "l": "Phosphorylation of PKC theta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138459", "l": "WNT5A:FZD4 is endocytosed (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179413", "l": "Activated PKC-alpha  activate MMP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109700", "l": "AKT2 binds PIP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617941", "l": "Expression of superoxide dismutase 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017491", "l": "RHOJ GEFs activate RHOJ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005545", "l": "1-phosphatidylinositol binding", "d": ["Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39741", "l": "3,12-dihydroxydodecanoate + H2O + NADP(+) => 3-hydroxydodecanoate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27896", "l": "cytidine + phosphate => 3'-CMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42854", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine => 3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10961", "l": "(S)-lactate => (R)-lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36337", "l": "D-glucarate + 2 H(+) + NADH => D-glucuronate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63297", "l": "an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191062", "l": "Autocatalytic phosphorylation of Klotho-bound FGFR1c (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9855252", "l": "SDHA:SDHB binds to SDHC:SDHD (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72615", "l": "H(+)(out) + L-alanyl-L-valine(out) = H(+)(in) + L-alanyl-L-valine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60647", "l": "3'-phosphoadenylyl sulfate + androsterone <=> adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42710", "l": "N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine => guanosine(46) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390154", "l": "MATS is phosphorylated by HPO dimer and binds to phosphorylated WTS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75705", "l": "14,15-epoxy-12-hydroxy-(10E)-eicosenoate => 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60392", "l": "Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O = Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53127", "l": "all-trans-lycopene <=> delta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52517", "l": "trans-4-hydroxy-L-proline + ubiquinone-10 => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043730", "l": "5-ureido-4-imidazole carboxylate hydrolase activity", "d": ["Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62824", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57667", "l": "(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54474", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanoate => 1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698179", "l": "FLT3 mutants recruit PIK3R1 through phosphorylated GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420975", "l": "Ca impermeable AMPA receptor ligand binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654571", "l": "Activated FGFR1 binds FRS3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140981", "l": "medium-chain fatty acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822532", "l": "ADAMTS13 cleaves VWF multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870466", "l": "RGGT:CHM binds RABs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31741", "l": "a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine => a 4'-hydroxyisoflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33941", "l": "H2O + N(omega)-hydroxy-L-arginine + NAD(+) => H(+) + L-arginine + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75820", "l": "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000327", "l": "PLK1 phosphorylates BORA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54865", "l": "H(+) + NADPH + O2 + sulcatone => 4-methylpent-3-en-1-yl acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47221", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,16alpha-dihydroxy-androst-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9859148", "l": "BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41661", "l": "dihydrosanguinarine + NAD(+) => NADH + sanguinarine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198621", "l": "AKT phosphorylates caspase-9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201515", "l": "Active ALK recruits PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0016892", "l": "RNA endonuclease activity, producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57126", "l": "2-hydroxy-5-oxoproline => 2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654399", "l": "Activated FGFR2 binds FRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68964", "l": "2-hydroxyoctadecanoate + O2 = 2-oxooctadecanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27610", "l": "formate + H(+) = CO2 + H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9641111", "l": "Parkin transfers Ub to misfolded proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852331", "l": "GTSE1 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45742", "l": "5-hydroxyectoine + CO2 + succinate => 2-oxoglutarate + L-ectoine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23671", "l": "apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin <=> AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445077", "l": "Transport of L1 from C-domain to P-domain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61986", "l": "NAD(+) + ubiquinol-10 => H(+) + NADH + ubiquinone-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72897", "l": "4-O-demethylbarbatate + 6 CO2 + 8 CoA + H2O + 2 S-adenosyl-L-homocysteine => 2 acetyl-CoA + 3 H(+) + 6 malonyl-CoA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77772", "l": "13-cis-retinol + a fatty acyl-CoA => 13-cis-retinyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62852", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74243", "l": "H2O + L-alanyl-tRNA(Pro) = H(+) + L-alanine + tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098782", "l": "mechanosensitive potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by a channel that opens in response to a mechanical stress."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17305", "l": "H2O + N(omega),N(omega)-dimethyl-L-arginine = dimethylamine + L-citrulline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948015", "l": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388596", "l": "Melanocortin receptors bind melanocortins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77826", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-alanine + O2 <=> (2S)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051118", "l": "glucan endo-1,3-alpha-glucosidase activity", "d": ["Catalysis of the endohydrolysis of (1->3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610723", "l": "GLI proteins bind SUFU (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950344", "l": "Expression of BolA-like protein 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634390", "l": "ERBB2 homodimer phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014320", "l": "SARM binds viral dsRNA:TLR3:TICAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35726", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34902", "l": "malonyl-CoA + S-adenosyl-L-methionine <=> malonyl-CoA methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56294", "l": "4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => fenbendazole + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983194", "l": "Kinesin-1 is a heterotetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60750", "l": "CoA + pyrethrin II => (1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65334", "l": "chrodrimanin E + H2O + NADP(+) => H(+) + NADPH + O2 + verruculide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693540", "l": "MRN activates ATM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2545203", "l": "Deacetylation of cleaved cohesin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57183", "l": "L-lysyl-[protein] + methylglyoxal <=> N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22339", "l": "glycine betaine + L-homocysteine <=> L-methionine + N,N-dimethylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0052744", "l": "phosphatidylinositol monophosphate phosphatase activity", "d": ["Catalysis of the reaction: phosphatidyl-1D-myo-inositol monophosphate + H2O = phosphatidylinositol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867613", "l": "PICALM binds R-SNAREs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71842", "l": "dehydroepiandrosterone 3-sulfate(out) <=> dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60846", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate => a 5'-end diphospho-guanosine in mRNA + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39167", "l": "H(+) + malonyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74949", "l": "(3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + CO2 + succinate => (3R)-3-[(carboxymethyl)amino]butanoate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033767", "l": "4-hydroxyacetophenone monooxygenase activity", "d": ["Catalysis of the reaction: 4'-hydroxyacetophenone + H+ + NADPH + O2 = 4-hydroxyphenyl acetate + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.50", "l": "\"human endogenous retrovirus K endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34697", "l": "Delta(6)-protoilludene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50768", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32929", "l": "a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50960", "l": "cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine = H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939201", "l": "ESR dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37202", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019973", "l": "interleukin-13 binding", "d": ["Binding to interleukin-13."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62827", "l": "beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.41", "l": "\"polypeptide N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008349", "l": "MAP kinase kinase kinase kinase activity", "d": ["Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0008135", "l": "translation factor activity, RNA binding", "d": ["Functions during translation by binding to RNA during polypeptide synthesis at the ribosome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37439", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20224", "l": "(6S)-5,6,7,8-tetrahydrofolate + ATP + formate <=> (6R)-10-formyltetrahydrofolate + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39172", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH => (3R)-hydroxyeicosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.117", "l": "\"aflatoxin B synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32025", "l": "avermitilol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130194", "l": "ABL phosphorylates WAVEs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65329", "l": "A + chrodrimanin F => AH2 + chrodrimanin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9670673", "l": "FIX is secreted (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168768", "l": "JAK2 binds STAT1/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23610", "l": "cyanurate + isopropylamine => H(+) + H2O + N-isopropylammelide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10462", "l": "prostaglandin C1 => prostaglandin A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74765", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => rhamnetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8943279", "l": "GGT dimers hydrolyse GSH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047595", "l": "6-hydroxynicotinate reductase activity", "d": ["Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24442", "l": "ADP + H(+) + 2 phosphate(in) => ATP + H2O + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0004691", "l": "cAMP-dependent protein kinase activity", "d": ["cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61934", "l": "(S)-miconazole(out) + ADP + H(+) + phosphate => (S)-miconazole(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50241", "l": "[hyaluronan](n) => n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008754", "l": "O antigen ligase activity", "d": ["Catalysis of the reaction: Lipid A-core + colanic acid = MLPS."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390673", "l": "CHRM2,4 bind acetylcholine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757686", "l": "SERPINA6 binds PREDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55687", "l": "chorismate + NH4(+) <=> 4-amino-4-deoxychorismate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428205", "l": "ACER2 hydrolyzes ceramide (Golgi) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676599", "l": "sBAFF trimer binds BAFFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37399", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809680", "l": "MTMR12 binds MTM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9008043", "l": "MAPK8 phosphorylation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008502", "l": "melatonin receptor activity", "d": ["Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033828", "l": "glucosylglycerol-phosphate synthase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + ADP-glucose = 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47543", "l": "7-oxolithocholate + H(+) + NADPH <=> NADP(+) + ursodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51567", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373747", "l": "Phosphorylation of nephrin by FYN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31737", "l": "3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 3-oxocholan-24-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48973", "l": "ATP + H2O + phosphite(out) => ADP + H(+) + phosphate + phosphite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73917", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + 6 CO2 + 7 CoA + H2O => acetyl-CoA + 4 H(+) + 6 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186786", "l": "Autophosphorylation of PDGF beta receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17662", "l": "ATP + CoA + succinate => ADP + phosphate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58602", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine => 2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940554", "l": "MMP2 cleaves OPTC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195304", "l": "Association of beta-catenin with the destruction complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13034", "l": "aldehydo-D-galactose 6-phosphate => keto-D-tagatose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71155", "l": "TAT deaminates tyrosine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940134", "l": "FOLR2 binds FOLA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37940", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8R)-hydroxy-(11R,12R)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109527", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45182", "l": "2 CoA + 2 H(+) + N(1),N(8)-bis(coumaroyl)-spermidine => 2 (E)-4-coumaroyl-CoA + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804741", "l": "MDM2 forms homo- or heterodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49022", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide => 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418200", "l": "SRC-1 bound to ARRB2 is not activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69165", "l": "H2O + N-(4-aminobutyl)-3-aminopropanal + NAD(+) => 2 H(+) + N-(2-carboxyethyl)putrescine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825780", "l": "TBX3-dependent ID1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67585", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65376", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.375", "l": "\"NNS virus cap methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760399", "l": "ILF3 and HOXC8 bind CDH11 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41737", "l": "3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) => adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804741", "l": "MDM2 forms homo- or heterodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78870", "l": "a medium-chain (3R)-hydroxyacyl-CoA <=> a medium-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052867", "l": "phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678998", "l": "Endosomal TLRs pass through the Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0016494", "l": "C-X-C chemokine receptor activity", "d": ["Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40093", "l": "26-oxohexacosanoate + H(+) + NADH => 26-hydroxyhexacosanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031796", "l": "type 1 metabotropic GABA receptor binding", "d": ["Binding to a type 1 metabotropic GABA receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75369", "l": "cytidine(out) => cytidine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64682", "l": "CoA + ethyl benzoate => benzoyl-CoA + ethanol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42702", "l": "6-carboxyhexanoyl-[ACP] + H(+) + methanol => 6-carboxyhexanoyl-[ACP] methyl ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39170", "l": "H(+) + malonyl-CoA + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53774", "l": "chenodeoxycholoyl-CoA + lithocholate => chenodeoxycholate + lithocholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.11", "l": "\"Xaa-Pro dipeptidyl-peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30331", "l": "all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.24", "l": "\"beta-carotene 3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46058", "l": "(11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050550", "l": "pinene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate. This reaction can produce both alpha-pinene and beta-pinene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56963", "l": "a ribonucleoside 5'-triphosphate + pyruvate <=> a ribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78908", "l": "a short-chain fatty acyl-CoA + acetyl-CoA => a short-chain 3-oxoacyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168272", "l": "Binding of the influenza virion to the host cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28326", "l": "H2O + wogonin 7-O-beta-D-glucuronate = D-glucuronate + H(+) + wogonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61904", "l": "betaenone A + H(+) + NADPH + O2 = H2O + NADP(+) + stemphyloxin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097160", "l": "polychlorinated biphenyl binding", "d": ["Binding to a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74654", "l": "CTP + N-acetyl-D-glucosamine <=> CDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43931", "l": "pregn-5-ene-3,20-dione <=> progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50733", "l": "4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] => (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16775", "l": "a ganglioside GM1 (d18:1(4E)) + H(+) + UDP => a ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63082", "l": "A + AMP + diphosphate + ilicicolin B => AH2 + ATP + ilicicolinate B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950362", "l": "EBI3:CANX binds IL12A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868071", "l": "Clathrin recruits PIK3C2A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9854368", "l": "ROS,RNS oxidize ACO2:4Fe-4S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24867", "l": "4-O-deacetyl-16-O-demethylvindoline + CO2 + succinate => (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19419", "l": "[phosphate](n+1) + a dolichyl phosphate => [phosphate](n) + a dolichyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36714", "l": "ATP + H(+) + H2O + O-ureido-D-serine <=> ADP + CO2 + D-cycloserine + NH4(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102691", "l": "UDP-glucose:benzyladenine 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine = H+ + benzyladenine-7-N-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21876", "l": "(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) = (S)-usnate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.199", "l": "\"(S)-usnate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167630", "l": "Formation of Nef CD28 cytoplasmic tail complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37892", "l": "aclacinomycin T + H2O => 15-demethylaclacinomycin T + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73884", "l": "guanidine(out) => guanidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3791319", "l": "NID1 degradation by MMP19 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78428", "l": "D-xylose(out) => D-xylose(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874082", "l": "MET phosphorylates PTK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72429", "l": "chloride(out) + K(+)(out) => chloride(in) + K(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19090", "l": "S-adenosyl-L-methionine + uroporphyrinogen III => H(+) + precorrin-1 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141437", "l": "Formation of the MCC complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351913", "l": "Caspase-mediated cleavage of TJP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49098", "l": "3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine => H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44619", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O <=> 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18504", "l": "ergosterol + NADP(+) <=> ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218814", "l": "PAK2 autophorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33402", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) <=> L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37300", "l": "H2O + L-alanyl-L-threonine => L-alanine + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12193", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814387", "l": "CASP14 cleaves filaggrin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420202", "l": "Secretin receptor binds secretin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76820", "l": "D-aspartate + H2O + NAD(+) => H(+) + NADH + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65711", "l": "alpha-D-mannose 1-phosphate + GDP-beta-L-galactose <=> beta-L-galactose 1-phosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50703", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164832", "l": "ATPase synthesizes ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71290", "l": "chloride(out) + L-arginine(out) + 2 Na(+)(out) <=> chloride(in) + L-arginine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70332", "l": "3-hydroxyphenylacetyl-CoA + H2O => 3-hydroxyphenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54074", "l": "beta-thujene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013435", "l": "RHOD auto-activates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47274", "l": "bisanhydrobacterioruberin + H2O => monoanhydrobacterioruberin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57423", "l": "NADH + 2 oxidized [cytochrome P450] <=> H(+) + NAD(+) + 2 reduced [cytochrome P450]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74810", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350769", "l": "trans-Golgi Network Coat Activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44697", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45777", "l": "(indol-3-yl)acetonitrile + 2 H2O => (indol-3-yl)acetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170964", "l": "FRS2 binds to active TrkA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75771", "l": "(9Z,12Z,15Z)-octadecatrienoate + H2O = (10S)-hydroxy-(12Z,15Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004605", "l": "phosphatidate cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20244", "l": "nicotinate + S-adenosyl-L-methionine <=> N-methylnicotinate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66277", "l": "tigogenin + UDP-alpha-D-glucose => H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65700", "l": "chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] = cholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52324", "l": "2 L-arginine + 4 O2 + 3 reduced [flavodoxin] = 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]", "d": [], "t": []}, {"i": "EC:1.14.14.47", "l": "\"nitric-oxide synthase (flavodoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74545", "l": "(E,E,E)-alpha-springene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389919", "l": "Grb2 binds pBTLA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102717", "l": "DIBOA-glucoside oxygenase activity", "d": ["Catalysis of the reaction: DIBOA-beta-D-glucoside + O2 + 2-oxoglutarate = TRIBOA-beta-D-glucoside + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74054", "l": "D-threonine(out) + L-alanine(in) <=> D-threonine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11759", "l": "ATP + biotin + L-lysyl-[protein] <=> AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080045", "l": "quercetin 3'-O-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3'-hydroxy group of a quercetin molecule."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52522", "l": "20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48457", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O => 2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47734", "l": "5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.12", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665707", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202721", "l": "JAM2 binds JAM3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76800", "l": "(2S)-2-aminobutan-1-ol + H2O + NAD(+) => 1-hydroxy-2-butanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61807", "l": "ATP + H(+) + L-alanine <=> diphosphate + L-alanyl-5'-AMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28820", "l": "5-dehydro-D-gluconate(in) + H(+)(in) => 5-dehydro-D-gluconate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433395", "l": "Dimerization of sSCF (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14376", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76471", "l": "AH2 + cob(III)alamin = A + cob(I)alamin + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77554", "l": "(9Z)-octadecenoyl-CoA + 3-octadecanoyl-sn-glycerol <=> 1-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688786", "l": "ATXN3 binds RAD23 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63037", "l": "H2O + octadecanamide => NH4(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140696", "l": "factor V -> factor Va + factor V activation peptide (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54696", "l": "4-hydroxybenzoate + ATP + holo-[4-hydroxyphenylalkanoate synthase] = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.50", "l": "\"4-hydroxybenzoate adenylyltransferase FadD22\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76144", "l": "picrinine + S-adenosyl-L-methionine => ervincine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54806", "l": "4,4'-disulfanyldibutanoate + H(+) + NADH => 2 4-sulfanylbutanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25255", "l": "ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate => ATP + N-acetyl-D-mannosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70169", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73821", "l": "choline(out) + 2 H(+)(in) => choline(in) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-984733", "l": "Kinesin-3 is a dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8862300", "l": "LYZ binds bacterial peptidoglycan (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015431", "l": "ABC-type glutathione S-conjugate transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17215", "l": "UDP-N-acetyl-alpha-D-mannosamine => UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204617", "l": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693153", "l": "PPM1K dephosphorylates p-BCKDH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53337", "l": "5,6-dihydrouridine(20) in tRNA + NADP(+) => H(+) + NADPH + uridine(20) in tRNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944215", "l": "Association of procollagen type XX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68515", "l": "(2Z,6Z)-farnesyl diphosphate <=> alpha-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14937", "l": "all-trans-antheraxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56585", "l": "1,2-epoxypropane + H2O => propane-1,2-diol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45009", "l": "H2O + N-(octadecanoyl)-sphinganine => octadecanoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.175", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34677", "l": "CMP-N,N-diacetyllegionaminate + diphosphate => CTP + N,N-diacetyllegionaminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48241", "l": "a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate => a ganglioside GT1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33020", "l": "(3S)-3,6-diaminohexanoate + acetyl-CoA => (3S)-6-acetamido-3-aminohexanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52407", "l": "3-dehydro-4-O-phospho-L-erythronate + H(+) <=> CO2 + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018754", "l": "GDIs bind RHOH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43467", "l": "H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70106", "l": "H(+) + o-quinone methide + penilactone D <=> penilactone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62544", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabagenin = dihydroouabagenin + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003789", "l": "actin filament severing activity", "d": ["Binding to an actin subunit and promoting its dissociation from an actin filament by a local change in actin subunit conformation and orientation, and severing of filaments."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3204311", "l": "AOX1 oxidises PXL to PDXate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55503", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70899", "l": "histidine => urocanate + NH4+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047871", "l": "disulfoglucosamine-6-sulfatase activity", "d": ["Catalysis of the reaction: N(2),6-disulfo-D-glucosamine + H2O = N-sulfo-D-glucosamine + H+ + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59023", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O <=> (9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59357", "l": "H2O + lactobiono-1,5-lactone => H(+) + lactobionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34584", "l": "2-oxoglutarate + O2 + pentalenolactone D => CO2 + H2O + pentalenolactone E + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757256", "l": "MCM3 binds MCM5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10319", "l": "2-oxoglutarate + O2 + thymine <=> 5-hydroxymethyluracil + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29583", "l": "guanosine(in) + H(+)(out) = guanosine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675790", "l": "MTORC1 dissociates from ULK complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72244", "l": "catechol + S-adenosyl-L-methionine => guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10226", "l": "ADP + H(+) + pyridoxal 5'-phosphate => ATP + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30228", "l": "dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O => dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177930", "l": "GAB1 phosphorylation by EGFR kinase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72664", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41352", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748991", "l": "XDH oxidises 6MP to 6TU (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005502", "l": "11-cis retinal binding", "d": ["Binding to 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426489", "l": "RISC binds inexactly matching target RNAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8850945", "l": "Casein kinase II phosphorylates PTEN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018754", "l": "GDIs bind RHOH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19215", "l": "an N-acetyl-L-cysteine-S-conjugate + CoA + H(+) => acetyl-CoA + an S-substituted L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68150", "l": "(2R)-octan-2-ol + NADP(+) => 2-octanone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9857578", "l": "MITF-M dimer binds GMPR gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63440", "l": "(2R)-3-phosphoglycerate + GTP + H(+) = 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.106", "l": "\"3-phospho-D-glycerate guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167419", "l": "The receptor:G-protein complex releases GDP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55073", "l": "2-oxobutanoate + H(+) => CO2 + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.57", "l": "\"fructuronate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11220", "l": "a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8963851", "l": "VD3 dissociates from GC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114684", "l": "Phosphorylation of Syntaxin-4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35800", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O => 7,8-dihydroneopterin 3'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23554", "l": "2-hydroxy-2-methylpropanal + H(+) + NADH => 2-methylpropane-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417908", "l": "P2RY1 binds ADP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444523", "l": "CXCR5 binds CXCL13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57332", "l": "H2O + 3 O2 + 3 propionate 3-nitronate = 3 3-oxopropanoate + 3 H(+) + H2O2 + 2 nitrate + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189439", "l": "ALAD condenses 2 dALAs to form PBG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71670", "l": "PKM dephosphorylates PEP to PYR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016505", "l": "peptidase activator activity involved in apoptotic process", "d": ["Binds to and increases the activity of a peptidase that is involved in the apoptotic process."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617683", "l": "EP300,CREBBP bind SOH-C481-FOXO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18253", "l": "(S)-malate + NADP(+) = CO2 + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189488", "l": "UROS transforms HMB to URO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004613", "l": "phosphoenolpyruvate carboxykinase (GTP) activity", "d": ["Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29032", "l": "L-glutamate(in) + 2 Na(+)(in) => L-glutamate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.171", "l": "\"rhamnogalacturonan hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36328", "l": "ADP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48573", "l": "3,5-dichlorocatechol + O2 => (2E,4E)-2,4-dichloromuconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45539", "l": "H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29446", "l": "H(+)(in) + L-alanine(in) <=> H(+)(out) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034878", "l": "2-hydroxyisonicotinate dehydrogenase activity", "d": ["Catalysis of the reaction: 2-hydroxyisonicotinate + acceptor + H2O = citrazinate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700149", "l": "Active ALK binds PLCG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854303", "l": "TBC1D11 binds RAB6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805479", "l": "TP53RK phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74677", "l": "2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaeol => AH2 + archaeol + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047230", "l": "flavonol-3-O-glucoside L-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56578", "l": "a globoside Gb4Cer + H(+) + UDP => a globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694527", "l": "Loss of SAR1B GTPase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2429719", "l": "MCPH1 sequesters condensin II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37731", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851866", "l": "MET binds RANBP10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72491", "l": "citrate(out) + maleate(in) = citrate(in) + maleate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23756", "l": "D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H(+) + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.37", "l": "\"D-arabinono-1,4-lactone oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77662", "l": "phomoidride A + S-adenosyl-L-methionine <=> (-)-phomoidride B + H(+) + methanol + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50860", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64724", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77836", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-glutamate + O2 => (2S)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]pentanedioate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21116", "l": "D-maltose + phosphate = beta-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.8", "l": "\"maltose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707186", "l": "ALOX5 binds ALOX5 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786110", "l": "JAK1 binds IL4R in IL13-bound IL13R type II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782138", "l": "ERCC5 and RPA bind TC-NER site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0003993", "l": "acid phosphatase activity", "d": ["Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39184", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH => (3R)-hydroxydocosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983519", "l": "IL35 binds IL12RB2:IL12RB2 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43161", "l": "adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48538", "l": "1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+) => 1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382057", "l": "Release of novel PDGFs as latent factors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694583", "l": "ABHD4 hydrolyses NAPE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004137", "l": "deoxycytidine kinase activity", "d": ["Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20393", "l": "holo-[citrate lyase ACP] + S-acetylphosphopantotheine = (R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.49", "l": "\"deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0003918", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity", "d": ["Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54372", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-(2S,3R,9R)-pristinol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.182", "l": "\"pristinol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6789092", "l": "NOX2 generates superoxide anion from oxygen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783530", "l": "gp130:JAKs bind CNTFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670414", "l": "KIT mutants bind SFKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55173", "l": "2-oxoglutarate + hexanoyl-CoA + O2 => 2-hydroxyhexanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47595", "l": "a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GP1c (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60032", "l": "8-oxo-GTP + H2O = 8-oxo-GDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190829", "l": "Lysosomal degradation of gap junction plaques (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832208", "l": "Expression of IRX2 during nephron development (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-442749", "l": "CaMKK autophosphorylates in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10290", "l": "H(+) + L-rhamnonate => H2O + L-rhamnono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53793", "l": "benzylthiol + O2 => benzothialdehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30453", "l": "isomultiflorenol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58416", "l": "(E)-4-hydroxynon-2-en-1-ol + NADP(+) = (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23586", "l": "7,8-dihydrofolate + ADP + H(+) + phosphate => 7,8-dihydropteroate + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17565", "l": "myo-inositol + S-adenosyl-L-methionine = 1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.40", "l": "\"inositol 1-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204500", "l": "CyP60 chaperones Basigin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32052", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate => adenosine 5'-tetraphosphate + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085992", "l": "SUMOylation of DAXX with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932070", "l": "ESR1 binds the AXIN1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73105", "l": "luteolin 4',7-dimethyl ether + S-adenosyl-L-homocysteine => diosmetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57630", "l": "H2O + ML-236C carboxylate => 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26363", "l": "2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+) => L-tyrosine + NADPH + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61793", "l": "ATP + L-tryptophan => diphosphate + L-tryptophyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015599", "l": "ATPase-coupled L-glutamine transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) -> ADP + phosphate + glutamine(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18560", "l": "1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA <=> 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23518", "l": "(2R)-3-phosphoglycerate + ADP + H(+) => (R)-glycerate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483219", "l": "PC is exchanged with PI by PITPNB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023028", "l": "MHC class I protein binding, via lateral surface", "d": ["Binding to a major histocompatibility complex class I molecules via the lateral surface."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213244", "l": "Loading of antigenic peptides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373741", "l": "SDK2 homophillic interaction (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033983", "l": "diaminobutyrate decarboxylase activity", "d": ["Catalysis of the reaction: L-2,4-diaminobutyrate + H+ = 1,3-diaminopropane + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58540", "l": "2 L-ascorbate + N-dodecanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20082", "l": "H2O + N-methylhexanamide => hexanoate + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71211", "l": "chlorate(out) + 2 Na(+)(out) = chlorate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62139", "l": "dGMP + GTP <=> dGDP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30491", "l": "L-valine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-valine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811508", "l": "ING2-bound EP300 acetylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77069", "l": "H(+) + NADPH + NH4(+) + pentanal => H2O + NADP(+) + pentylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202966", "l": "Caspase mediated cleavage of HIP-55 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247849", "l": "WLS dissociates from retromer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60028", "l": "(2E)-geranyl diphosphate + H2O = 4-terpineol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10469", "l": "D-xylulose 5-phosphate + phosphate => acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.484625558868103", "identifiers": [{"i": "GO:0046943", "l": "carboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)."], "t": []}, {"i": "REACT:R-HSA-390347", "l": "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63597", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681616", "l": "AP2 binds chlorpromazine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48156", "l": "a ganglioside GQ1b (d18:1(4E)) + H2O = a ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863718", "l": "AGFG1 binds VAMP7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13634", "l": "ATP + L-glutamate + putrescine => ADP + gamma-L-glutamylputrescine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9846501", "l": "B3GNT5 transfers GlcNAc to LacCer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.98.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9844057", "l": "SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59701", "l": "D-cellopentaono-1,5-lactone + H2O => D-cellopentaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196017", "l": "Dynamin is recruited to the gap junction plaque (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0052927", "l": "CTP:tRNA cytidylyltransferase activity", "d": ["Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' CC end + 2 diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0016248", "l": "channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66327", "l": "iodide(out) <=> iodide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042586", "l": "peptide deformylase activity", "d": ["Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017083", "l": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22426", "l": "an alkyl thiol + NH4(+) + pyruvate => an S-alkyl-L-cysteine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989779", "l": "Expression of ANKRD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22169", "l": "UDP-alpha-D-glucose => UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354073", "l": "Autophosphorylation of PTK2 at Y397 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043546", "l": "molybdopterin cofactor binding", "d": ["Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981610", "l": "Neuroglobin binds oxygen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9623384", "l": "α1-agonists bind ADRA1A,B,D (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10048", "l": "methanethiol + O-acetyl-L-homoserine = acetate + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13865", "l": "GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol = beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.142", "l": "\"chitobiosyldiphosphodolichol beta-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10250", "l": "diphosphate + dUMP + H(+) => dUTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944632", "l": "miR-106 microRNAs bind PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903875", "l": "corticosterone binding", "d": ["Binding to corticosterone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41666", "l": "chelirubine + NADH => dihydrochelirubine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390846", "l": "D2D3,4 bind to DA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.53", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391158", "l": "SIRP alpha binds CD47 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77975", "l": "dimethylallyl diphosphate + 5 isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + 5 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429694", "l": "CERT1-2 complex dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63878", "l": "(4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46945", "l": "(S)-2-amino-6-oxohexanoate + holo-[LYS2 peptidyl-carrier protein] + NADP(+) => H(+) + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49591", "l": "L-erythrulose 1-phosphate <=> D-erythrulose 4-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42277", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] => (4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40045", "l": "ADP + beta-citrylglutamate + H(+) + phosphate => ATP + citrate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050630", "l": "(iso)eugenol O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36498", "l": "alpha-D-glucose + ATP <=> ADP + alpha-D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851979", "l": "BTNL9 binds immune cell surfaces (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64581", "l": "(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate => diphosphate + nerylneryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102389", "l": "polyprenol reductase activity", "d": ["Catalysis of the reaction: NADP + a ditrans,polycis-dolichol = NADPH + H+ + a di-trans, poly-cis-polyprenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76229", "l": "(indol-3-yl)acetonitrile + sulfate + sulfur => (Z)-(indol-3-yl)-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27779", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) => 2-all-trans-octaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56467", "l": "1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43327", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79017", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol(out) => alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44022", "l": "2 H(+) + NADH + octadecanoate => H2O + NAD(+) + octadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050189", "l": "phosphoenolpyruvate phosphatase activity", "d": ["Catalysis of the reaction: H2O + phosphoenolpyruvate = phosphate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070506", "l": "high-density lipoprotein particle receptor activity", "d": ["Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76096", "l": "(11R)-19-oxocarlactone + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-carlactonoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59567", "l": "H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone <=> H(+) + N,N',N'',N'''-tetraacetylchitotetraonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9860292", "l": "Activated IKBKB phosphorylates IRF5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36792", "l": "H2O + N(omega)-hydroxy-L-arginine => hydroxyurea + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112379", "l": "Recruitment of elongation factors to form elongation complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:1904680", "l": "peptide transmembrane transporter activity", "d": ["Enables the transfer of a peptide from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-1500817", "l": "Glutathione is taken up by the bacterium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983147", "l": "Release of E3 from polyubiquitinated substrate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042781", "l": "3'-tRNA processing endoribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3132759", "l": "TCN1 binds RCbl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62652", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA = 6 CO2 + 7 CoA + H2O + naphtopyrone YWA1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1306965", "l": "Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61127", "l": "kaempferol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0062179", "l": "vitamin D 23-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-23 of any form of vitamin D."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35313", "l": "3-oxoisoheptadecanoyl-CoA + H(+) + NADPH => 3-hydroxyisoheptadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209924", "l": "Dopa is decarboxylated to dopamine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18580", "l": "3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine <=> 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40221", "l": "CoA + H(+) + malonate => H2O + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177930", "l": "GAB1 phosphorylation by EGFR kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140069", "l": "histone butyryltransferase activity", "d": ["Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110319", "l": "Elongation by POLH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682011", "l": "LC3 binds ATG7 dimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10033", "l": "[protein]-C-terminal-L-glutamine + H2O => [protein]-C-terminal-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67170", "l": "3-(3-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + 3-hydroxy-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785594", "l": "FANCD2 binds FANCI (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972949", "l": "POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73728", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate => (2S,3R,11R)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43750", "l": "AMP + diphosphate + hexacosanoyl-CoA => ATP + CoA + hexacosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14666", "l": "guanine + H(+) + H2O => NH4(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183122", "l": "Factor D cleaves C3b-bound Factor B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66698", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine => (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10177", "l": "(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) => (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700701", "l": "T-type VDCC bind T-type VDCC blockers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156832", "l": "INF-gamma induced phosphorylation of L13a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018457", "l": "perillyl-alcohol dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + perillyl alcohol = H+ + NADH + perillyl aldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327733", "l": "FN1 binds Collagen types I-V, VII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.17", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174202", "l": "Degradation of multiubiquitinated Securin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41311", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl (5Z,8Z,10E,12R,14Z)-hydroperoxyiecosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18717", "l": "3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.84", "l": "\"methylquercetagetin 6-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11575", "l": "FAD + H(+) + H2O + lithocholate <=> chenodeoxycholate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44742", "l": "H(+) + rifamycin SV + S-adenosyl-L-homocysteine => 27-O-demethylrifamycin SV + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56237", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417890", "l": "P2Y5 receptor can bind to LPA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32494", "l": "alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19301", "l": "histamine + S-adenosyl-L-methionine = H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.8", "l": "\"histamine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21441", "l": "a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 => a long-chain alkane + formate + H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20628", "l": "2 Fe(III)-[cytochrome c3] + H2 <=> 2 Fe(II)-[cytochrome c3] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1170539", "l": "Prolactin receptor is internalized (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65472", "l": "2-methylbutanoyl-CoA + ethanol = CoA + ethyl 2-methylbutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65228", "l": "(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) = H(+) + NADPH + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793485", "l": "PRKN polyubiquitinates RIPK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35753", "l": "ADP + D-kanosamine 6-phosphate + H(+) => ATP + kanosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46469", "l": "an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O => ADP + an N-(acyl)-sphingosylphosphocholine(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203553", "l": "eNOS binds NOSIP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034918", "l": "3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63944", "l": "a fatty acyl-CoA + sphinga-4E,14Z-dienine = an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015164", "l": "glucuronoside transmembrane transporter activity", "d": ["Enables the transfer of a glucuronosides from one side of a membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675656", "l": "EDA:EDAR binds EDARADD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47427", "l": "(2E,9Z)-octadecadienoyl-CoA + H2O <=> (3S)-hydroxy-(9Z-octadecenoyl)-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72735", "l": "UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) = UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35338", "l": "H(+) + isopentadecanoyl-CoA + malonyl-CoA <=> 3-oxoisoheptadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-350769", "l": "trans-Golgi Network Coat Activation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5655483", "l": "USP1 autocleavage (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465940", "l": "atRAL is reduced to atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109702", "l": "PDPK1 phosphorylates AKT2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21563", "l": "3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol <=> 1,4-dithiothreitol + 2,3-epoxyphylloquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36720", "l": "hexacosenoyl-CoA + sphinganine => CoA + H(+) + N-hexacosenoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0016901", "l": "oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule."], "t": []}, {"i": "EC:1.1.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20290", "l": "acetyl-CoA + H2O => acetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429157", "l": "ABCC4 accumulation of dense granule contents (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51219", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one <=> adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30522", "l": "GTP + H(+) + phosphoenolpyruvate <=> diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49528", "l": "(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.101", "l": "\"poly(ethylene terephthalate) hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1370505", "l": "PRLR is phosphorylated at Ser-349 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210944", "l": "Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48640", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11839", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine <=> CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0032028", "l": "myosin head/neck binding", "d": ["Binding to the head/neck region of a myosin heavy chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74398", "l": "2 (S)-lactate(in) + prostaglandin E1(out) <=> 2 (S)-lactate(out) + prostaglandin E1(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48232", "l": "acetyl-CoA + L-glutamate 5-semialdehyde = CoA + H(+) + N-acetyl-L-glutamate 5-semialdehyde", "d": [], "t": []}, {"i": "EC:2.3.1.271", "l": "\"L-glutamate-5-semialdehyde N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22467", "l": "L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17827", "l": "ADP + D-glucose 6-phosphate + H(+) => ATP + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20682", "l": "cis-zeatin + UDP-alpha-D-glucose => H(+) + O-beta-D-glucosyl-cis-zeatin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014456", "l": "GDIs block activation of RHOG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5686430", "l": "MUS81 binds EME1, EME2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433506", "l": "Phosphorylation of APS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72624", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-dihydroceramide => a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-dihydroceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59030", "l": "4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => (Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45005", "l": "(R)-carnitine + 2,6-dimethylheptanoyl-CoA => CoA + O-2,6-dimethylheptanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56009", "l": "4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47610", "l": "3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA => 3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78342", "l": "2',3'-cGAMP + H2O <=> 5'-pGpA(2'-5') + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11741", "l": "2 glutathione + NADP(+) => glutathione disulfide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835244", "l": "Expression of ZIC1 in the neural plate border (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16640", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine <=> [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917700", "l": "MVB Vesicle Formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610732", "l": "GSK3 phosphorylates p-GLI3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77140", "l": "1D-myo-inositol 2,3-bisphosphate + H2O => 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45513", "l": "phycocyanobilin-L-cysteinyl(155)-[C-phycocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[C-phycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9865630", "l": "Metallochaperone inserts 2Cu2+ into MT-CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40805", "l": "3,6-anhydro-L-galactonate + 2 H(+) + NADPH => 3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30299", "l": "2-oxoglutarate + a methylated nucleobase within DNA + O2 = a nucleobase within DNA + CO2 + formaldehyde + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.33", "l": "\"DNA oxidative demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25237", "l": "ATP + CDP = ADP + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60941", "l": "(9Z)-hexadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => (9Z)-16-hydroxyhexadec-9-enoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55593", "l": "2 (3R)-hydroxydecanoyl-[ACP] + H2O => (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31488", "l": "soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose => H(+) + soyasaponin III + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21987", "l": "3'-phosphoadenylyl sulfate + choline <=> adenosine 3',5'-bisphosphate + choline sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16660", "l": "H2O + inosine <=> D-ribose + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71563", "l": "5-aminomethyl-dUMP in DNA + acetyl-CoA = 5-acetylaminomethyl-dUMP in DNA + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61655", "l": "2,3-dihydroxybenzoate + ATP + holo-[ACP] <=> 2,3-dihydroxybenzoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47982", "l": "dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose => dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61728", "l": "a 3-dehydro-D-guloside = a 3-dehydro-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10339", "l": "citrate <=> D-threo-isocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9651456", "l": "SERPING1 variant does not bind factor XIIa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38239", "l": "(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA = 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799761", "l": "TP53 binds PPP1R13L (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936676", "l": "Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62653", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA => 6 CO2 + 7 CoA + H2O + naphtopyrone YWA1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25534", "l": "diphosphate + ent-cassa-12,15-diene => ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2471621", "l": "Endostatin degradation by cathepsins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.63", "l": "\"2-hydroxyacyl-CoA lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176175", "l": "Stalling of DNA replication fork and RPA binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25697", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66017", "l": "bromide + H2O2 => H2O + hypobromite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21017", "l": "H2O + L-asparagine => L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67710", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(out) + ADP + H(+) + phosphate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16711", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2248891", "l": "M6PR transports activated ARSA to the lysosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686578", "l": "Activated ATM phosphorylates ABL1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0030554", "l": "adenyl nucleotide binding", "d": ["Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174757", "l": "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668789", "l": "LA,TNFSF14 binds LTBR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15816", "l": "1H-imidazole + acetyl-CoA <=> CoA + N-acetylimidazole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31192", "l": "(3S)-hydroxydecanoyl-CoA => (2E)-decenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39715", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 = (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052757", "l": "chondroitin hydrolase activity", "d": ["Catalysis of the hydrolysis of hexosaminic linkages in chondroitin, a linear polymer structure composed of the repeating disaccharide unit [->4)-D-glucuronic acid-(1->3)-N-acetyl-D-galactosamine-(1-], also written as [->4GlcUA1->3GalNAc1-]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17017", "l": "acetyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] = CoA + N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70951", "l": "D-serine + H2O + O2 = 3-hydroxypyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11339", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine <=> deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69159", "l": "spermine dialdehyde <=> acrolein + N-(4-aminobutyl)-3-aminopropanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35592", "l": "H2 + n sulfur => H(+) + hydrogen sulfide + (n-1) sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3296301", "l": "CCRL2 binds CCL19 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57071", "l": "3-oxoisoapionate + ATP <=> 3-oxoisoapionate 4-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050782", "l": "galactose uniporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9604308", "l": "NICD4 traffics to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66534", "l": "diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203977", "l": "SAR1 Activation And Membrane Binding (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.289590649673869", "identifiers": [{"i": "GO:0016410", "l": "N-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule."], "t": []}, {"i": "REACT:R-HSA-177160", "l": "phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33674", "l": "an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O <=> 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32099", "l": "S-adenosyl-L-methionine + TRIBOA beta-D-glucoside = DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.241", "l": "\"2,4,7-trihydroxy-1,4-benzoxazin-3-one-glucoside 7-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624133", "l": "ARL3:GTP binds the UNC119B complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54922", "l": "13-cis-retinal + H(+) + NADPH => 13-cis-retinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5674019", "l": "BRAP binds KSR1:MARK3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855232", "l": "RELN:VLDLR binds DAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507871", "l": "Aquaporins passively transport glycerol out of cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43267", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA <=> 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14760", "l": "2 Fe(III)-[cytochrome c] + L-galactono-1,4-lactone <=> 2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74393", "l": "methylamine(in) => methylamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21351", "l": "8 H(+) + 10 malonyl-CoA <=> 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47081", "l": "17beta-hydroxyestr-4-en-3-one + H(+) + NADPH => 17beta-hydroxy-5beta-estran-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37337", "l": "3-(carbamoylamino)-2-methylpropanoate + H(+) => 5,6-dihydrothymine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77136", "l": "1D-myo-inositol 1,2-bisphosphate + H2O => 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52353", "l": "(24S)-hydroxycholesterol 24-sulfate + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 3,24-disulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47062", "l": "4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60159", "l": "ATP + D-galactose(out) + H2O <=> ADP + D-galactose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-549304", "l": "OCT3 mediates renal clearance of organic cations (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042043", "l": "neurexin family protein binding", "d": ["Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33710", "l": "ATP + L-threonine <=> ADP + H(+) + O-phospho-L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46919", "l": "H2O + juvenile hormone I <=> H(+) + juvenile hormone I carboxylate + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63392", "l": "A + Fe(II)-heme o + H2O = AH2 + Fe(II)-heme i", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858482", "l": "DVL is recruited to the receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.34", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9854415", "l": "ACAT1 tetramer acetylates IDH2 dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849908", "l": "SALM4 binds flotillin-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61781", "l": "keto-L-tagatose => keto-L-sorbose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018880", "l": "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69659", "l": "H2O + kaempferol 3-O-beta-D-glucoside = beta-D-glucose + kaempferol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70960", "l": "D-tyrosine + H2O + O2 => 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1474210", "l": "Collagen type III degradation by MMP14 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164423", "l": "PhosphoChREBP (Thr 653) is exported to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.5", "l": "\"prolyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163320", "l": "Association of mTERF with the termination sequence (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36486", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + malonyl-CoA <=> (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56760", "l": "24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011145", "l": "LHX2,(LHX9) binds the ROBO3 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65231", "l": "(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) <=> H(+) + NADPH + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18312", "l": "an N-acyl-D-amino acid + H2O <=> a carboxylate + a D-alpha-amino acid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446221", "l": "GMPPB converts Mannose-1-phosphate to GDP-Mannose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45706", "l": "(E)-sinapaldehyde + H(+) + NADPH => (E)-sinapyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.2", "l": "\"hydrogen dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22811", "l": "6-hydroxynicotinate + H2O + O2 <=> 2,6-dihydroxynicotinate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225961", "l": "Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14935", "l": "N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate => H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29564", "l": "ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate => ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003985", "l": "acetyl-CoA C-acetyltransferase activity", "d": ["Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701557", "l": "AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52584", "l": "chenodeoxycholoyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18726", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA => acetyl-CoA + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247849", "l": "WLS dissociates from retromer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52159", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21763", "l": "(3S)-3-hydroxybutanoyl-CoA <=> (3R)-3-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65448", "l": "butanoyl-CoA + ethanol = CoA + ethyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034053", "l": "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196753", "l": "2xPPCS ligates PPanK with Cys (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30632", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate => beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3858489", "l": "ppDVL binds DAAM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14848", "l": "L-aspartate 4-semialdehyde + pyruvate <=> (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32108", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine => H(+) + pterostilbene + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52204", "l": "butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.23", "l": "\"chloroacetanilide N-alkylformylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47463", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + CoA <=> (3Z)-dodecenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14188", "l": "3-phenylpyruvate + H(+) <=> 2-phenylacetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73560", "l": "dGTP(out) + UTP(in) => dGTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76277", "l": "Na(+)(in) + uracil(in) => Na(+)(out) + uracil(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.71", "l": "\"sortase B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42659", "l": "diphthine methyl ester-[translation elongation factor 2] + H2O <=> diphthine-[translation elongation factor 2] + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63234", "l": "NAD(+) + octanoyl-CoA => (2E)-octenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10726", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-6-deoxy-alpha-D-talose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158860", "l": "SULT1A1 dimer sulfonates NHABP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034926", "l": "pyrene-4,5-epoxide hydrolase activity", "d": ["Catalysis of the reaction: pyrene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53510", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18203", "l": "(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46839", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11037", "l": "a quaternary ammonium(out) + ATP + H2O => a quaternary ammonium(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60381", "l": "L-dehydroascorbate(out) => L-dehydroascorbate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53496", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30212", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrous oxide => 2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192061", "l": "CYP46A1 24-hydroxylates CHOL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9709109", "l": "DHFR dimer binds DHFR inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19714", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17999", "l": "Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine => Co-precorrin-2 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49552", "l": "H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] = H(+) + L-lysyl-[protein] + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374723", "l": "Nociceptin receptor binds to nociceptin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48478", "l": "a ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate => a ganglioside GT1a (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030779", "l": "10-hydroxydihydrosanguinarine 10-O-methyltransferase activity", "d": ["Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54363", "l": "4-methyl-2-oxopentanoate + H(+) <=> 3-methylbutanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56437", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17975", "l": "5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine => diphosphate + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373717", "l": "DCC interacts with DIP13alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43105", "l": "AH2 + an N-acyleicosasphinganine + O2 => A + an N-acyleicosasphing-4-enine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209573", "l": "p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53803", "l": "lithocholoyl-CoA + ursodeoxycholate <=> lithocholate + ursodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40428", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35707", "l": "(2S)-versicolorone + H(+) + NADPH + O2 = (3S)-versiconol acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72019", "l": "2-oxoglutarate + H(+) + O2 + trihazone A = 2 CO2 + H2O + succinate + trihazone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390438", "l": "FAR2 reduces PalmCoA to HXOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432010", "l": "Aquaporin-1 passively transports water into cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56047", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30134", "l": "H2O + octanoyl-[ACP] <=> H(+) + holo-[ACP] + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16197", "l": "(3S)-3-hydroxybutanoyl-CoA + NADP(+) = acetoacetyl-CoA + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.157", "l": "\"3-hydroxybutyryl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77216", "l": "dATP + H2O => 2-deoxyribose 5-triphosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78065", "l": "a 1,2-diacylglycerol + an all-trans-retinyl ester => a triacylglycerol + all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114683", "l": "Phosphorylation of Platelet Sec-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39062", "l": "26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3321805", "l": "NSL acetylates histone H4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64875", "l": "D-ribulose 1-phosphate <=> dihydroxyacetone phosphate + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47138", "l": "AMP + diphosphate + lithocholoyl-CoA => ATP + CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035100", "l": "ecdysone binding", "d": ["Binding to 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197690", "l": "Detachment of WASP/WAVE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17592", "l": "2,2'-iminodipropanoate + H2O + NAD(+) <=> H(+) + L-alanine + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42296", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.n4", "l": "\"1-acyl-sn-glycerol-3-phosphate acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72941", "l": "2 Na(+)(in) + propanoate(in) => 2 Na(+)(out) + propanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5685230", "l": "CHEK1 phosphorylates RAD51 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036348", "l": "hydantoin racemase activity", "d": ["Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047727", "l": "isobutyryl-CoA mutase activity", "d": ["Catalysis of the reaction: isobutyryl-CoA = butanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32401", "l": "(1S,4S)-dihydrocarvone + H(+) + NADH => (1S,2R,4S)-neodihydrocarveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15597", "l": "a Fe(III)-siderophore(out) + ATP + H2O = a Fe(III)-siderophore(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37576", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56520", "l": "Fe-coproporphyrin III + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine", "d": [], "t": []}, {"i": "EC:1.3.98.6", "l": "\"AdoMet-dependent heme synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66412", "l": "ATP + glutathione(in) + H2O + taurochenodeoxycholate(in) = ADP + glutathione(out) + H(+) + phosphate + taurochenodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25891", "l": "dihydroxyacetone phosphate + iminosuccinate <=> H(+) + 2 H2O + phosphate + quinolinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57327", "l": "acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] <=> CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47956", "l": "3-maleylpyruvate + H2O = H(+) + maleate + pyruvate", "d": [], "t": []}, {"i": "EC:3.7.1.23", "l": "\"maleylpyruvate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048000", "l": "isoflavone 3'-hydroxylase activity", "d": ["Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73102", "l": "3'-dephospho-CoA(in) + AMP(out) <=> 3'-dephospho-CoA(out) + AMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64696", "l": "benzyl alcohol + NAD(+) = benzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57336", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050474", "l": "(S)-norcoclaurine synthase activity", "d": ["Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.26", "l": "\"intermediate cleaving peptidase 55\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23558", "l": "gamma-L-glutamyl-D-alanine + NH4(+) => D-alanine + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58555", "l": "15alpha-stemmadenine intermediate II + H2O <=> (16R)-deshydroxymethyl-stemmadenine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14777", "l": "AMP + H(+) + H2O = IMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445072", "l": "Interaction of PAK1 with Rac1-GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77376", "l": "H(+) + heptadecanoate + hnu => CO2 + hexadecane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61436", "l": "ADP + H2O = AMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2172666", "l": "RB1 binds condensin II (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67333", "l": "13-cis-retinal + H2O + NAD(+) => 13-cis-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.81", "l": "\"ADAM10 endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418925", "l": "ADORA2A,B bind Ade-Rib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811412", "l": "Active ARF recruits coatomer to the Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57665", "l": "(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] => alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33168", "l": "2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49415", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose <=> alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70932", "l": "chloride(out) + dopamine(out) + 2 Na(+)(out) => chloride(in) + dopamine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27368", "l": "bromide + S-adenosyl-L-methionine <=> bromomethane + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38696", "l": "a cardiolipin(in) => a cardiolipin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24614", "l": "estrone + H(+) + NADH => 17beta-estradiol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42493", "l": "3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 => 3'-N-debenzoyltaxol + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033916", "l": "beta-agarase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product."], "t": []}, {"i": "EC:3.2.1.81", "l": "\"beta-agarase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44934", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14516", "l": "ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine <=> ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782336", "l": "ADAT1 deaminates adenosine-37 in tRNA(Ala) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56851", "l": "1,6-didemethyltoxoflavin + S-adenosyl-L-methionine <=> H(+) + reumycin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380224", "l": "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56247", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate + apo--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69987", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+) = (22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66816", "l": "2 Na(+)(in) + tetrahydroxoborate(in) = 2 Na(+)(out) + tetrahydroxoborate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390835", "l": "DRD1,5 bind DA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.528826417782284", "identifiers": [{"i": "GO:0016854", "l": "racemase and epimerase activity", "d": ["Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule."], "t": []}, {"i": "EC:5.1.-.-", "l": "\"Racemases and epimerases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618107", "l": "ATP binding to HSP90 triggers conformation change (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60147", "l": "ATP + L-glutamate + L-glutamyl-[protein] <=> ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20568", "l": "(2E)-geranyl diphosphate + H2O <=> (1S,2S,4R)-endo-fenchol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983152", "l": "Transfer of ubiquitin from E1 to E2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033530", "l": "TYSND1 cleaves HSD17B4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47682", "l": "D-tagatopyranose 1-phosphate + NH4(+) => D-galactosamine 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180728", "l": "Association of Ran-GTP with importin-beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605624", "l": "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50914", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+) => 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205231", "l": "Dimerization of KIT upon SCF binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40873", "l": "(2E,9Z)-octadecadienoyl-CoA + FADH2 => (9Z)-octadecenoyl-CoA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9706399", "l": "RHOBTB3 hydrolyzes ATP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875531", "l": "MET binds TNS4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800035", "l": "IGFBP3 binds TMEM219 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805785", "l": "AKT phosphorylates PHF20 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56290", "l": "H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase] => albendazole + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19969", "l": "hydroxylamine + O2 = H(+) + H2O + nitrite", "d": [], "t": []}, {"i": "EC:1.7.3.6", "l": "\"hydroxylamine oxidase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111264", "l": "Addition of nucleotides between position +11 and +30 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71831", "l": "chloride(out) + creatine(out) + 2 Na(+)(out) = chloride(in) + creatine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63531", "l": "[thioredoxin]-dithiol + H2O2 <=> [thioredoxin]-disulfide + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68446", "l": "(3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal => 5-cis-lycopene + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73142", "l": "lithocholate(out) <=> lithocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.6", "l": "\"acetolactate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202222", "l": "Phosphorylation of PKC theta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78301", "l": "guanine + queuosine(34) in tRNA(Tyr) => guanosine(34) in tRNA(Tyr) + queuine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60913", "l": "cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine => H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027625", "l": "5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.41", "l": "\"complement subcomponent C1r\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0032182", "l": "ubiquitin-like protein binding", "d": ["Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809707", "l": "MTMR12 binds MTMR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68404", "l": "(2R,3S)-iso(homo)2citrate + NAD(+) = 2-oxoheptanedioate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40392", "l": "1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA => 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70858", "l": "L-glutamine(out) + L-serine(in) + Na(+)(out) <=> L-glutamine(in) + L-serine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140594", "l": "xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity", "d": ["Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74716", "l": "Insulin binds the insulin receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176298", "l": "Activation of claspin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29398", "l": "H2O + UTP <=> diphosphate + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373073", "l": "Receptors CCR1, 2 and 8 bind CCL16 ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420883", "l": "Opsins act as GEFs for G alpha-t (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44011", "l": "a 2-methyl-branched fatty aldehyde + H2O + NAD(+) <=> a 2-methyl fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191402", "l": "Reduction of presqualene diphosphate to form squalene (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58493", "l": "ATP + Fe(III)-enterobactin(out) + H2O => ADP + Fe(III)-enterobactin(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9681294", "l": "IL6R binds IL6R inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41080", "l": "1-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698754", "l": "p-STAT5 binds the NOX4 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661820", "l": "Bacterial GUSB hydrolyses BDG to BIL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654515", "l": "KAL1 binds HS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26162", "l": "thalianol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29103", "l": "5 H(+)(in) + menaquinone-8 + NADH = 4 H(+)(out) + menaquinol-8 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38855", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15201", "l": "6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.108", "l": "\"6-hydroxymellein O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831011", "l": "Expression of SIX1 in metanephric mesenchyme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156682", "l": "PLK1 phosphorylates NUDC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33569", "l": "acetaldehyde + AH2 => A + ethanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450971", "l": "NNT dimer transfers proton from NADPH to NAD+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58977", "l": "H2O + malonaldehyde + O2 => 3-oxopropanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19685", "l": "(E)-feruloyl-CoA + tyramine = CoA + H(+) + N-[(E)-feruloyl]tyramine", "d": [], "t": []}, {"i": "EC:2.3.1.110", "l": "\"tyramine N-feruloyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420117", "l": "VEGFR2 autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24437", "l": "H2 + methanophenazine => dihydromethanophenazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67511", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67377", "l": "glycyl-L-histidine + H2O => glycine + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388832", "l": "PI3K binds CD28 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.217", "l": "\"3-dehydrotetronate 4-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65637", "l": "sphinga-(4E,8E)-dienine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781832", "l": "Defective MPI does not  isomerize Fru6P to Man6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028260", "l": "δ12-PGJ3 spontaneously dehydrates to  15d-PGJ3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8857686", "l": "FITM1, FITM2 bind TAGs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034561", "l": "1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity", "d": ["Catalysis of the reaction: 1,2-bis(4-hydroxyphenyl)-2-propanol = 4,4'-dihydroxy-alpha-methylstilbene + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27564", "l": "(2E)-geranyl diphosphate + 7 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 7 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20440", "l": "5D-5-O-methyl-chiro-inositol + NADP(+) <=> 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78535", "l": "N-acetyl-alpha-neuraminate(out) + 2 Na(+)(out) = N-acetyl-alpha-neuraminate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19813", "l": "a 2-oxocarboxylate + L-asparagine = 2-oxosuccinamate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863463", "l": "STON2 binds SYT proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30264", "l": "H2O2 + 2 L-ascorbate => 2 H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332235", "l": "CBL binds TGFBR2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15381", "l": "O2 + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO", "d": [], "t": []}, {"i": "EC:1.13.11.24", "l": "\"quercetin 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35060", "l": "chloramphenicol(in) + H(+)(out) => chloramphenicol(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028820", "l": "Formation of VAF (virus-activated factor) complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29337", "l": "L-alanine + L-glutamate => H2O + L-alanyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047321", "l": "diphosphate-protein phosphotransferase activity", "d": ["Catalysis of the reaction: microsomal-membrane protein + diphosphate = diphosphate + O-phospho-microsomal-membrane protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.22", "l": "\"3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45346", "l": "a globoside NORint (d18:1(4E)) + H(+) + UDP => a globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341669", "l": "Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34783", "l": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74012", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2 => [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50864", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950183", "l": "IL12B binds IL23A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.38", "l": "\"beta-D-fucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450474", "l": "MK2 phosphorylates BRF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341048", "l": "SUMOylation of RXRA with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44672", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835944", "l": "ADAR1 binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23369", "l": "H(+) + phenylglyoxylate => benzaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46764", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.43", "l": "\"palmitoyl-[glycerolipid] 3-(E)-desaturase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977371", "l": "Factor I inactivates Factor H-boundC3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67527", "l": "4,8-dimethylnonanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15305", "l": "betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.8", "l": "\"betaine-aldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349404", "l": "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52146", "l": "(R)-2-(phosphonomethyl)malate + CoA + H(+) => 3-phosphonopyruvate + acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164506", "l": "Gap repair completes provirus integration (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32588", "l": "(1R,4R)-dihydrocarvone + H(+) + NADPH + O2 => (3R,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.1", "l": "\"alkaline phosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67824", "l": "a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O = a lipid X + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112690", "l": "PTPN11 binds CBL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25477", "l": "(2E,6E)-farnesyl diphosphate => alpha-himachalene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395320", "l": "Latent TGF-beta-1 binds integrins (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938815", "l": "RNF152 polyubiquitinates RRAGA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052641", "l": "benzoic acid glucosyltransferase activity", "d": ["Catalysis of the reaction: benzoic acid + UDP-glucose = benzoic acid glucose ester + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73476", "l": "D-arginine(in) + L-ornithine(out) => D-arginine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001849", "l": "complement component C1q complex binding", "d": ["Binding to a C1q complex, a component of the classical complement cascade."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14337", "l": "3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate = adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate", "d": [], "t": []}, {"i": "EC:2.8.2.7", "l": "\"UDP-N-acetylgalactosamine-4-sulfate sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714580", "l": "SLC6A3 binds DRIs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17170", "l": "acetyl-CoA + alpha-D-galactosamine 1-phosphate => CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.127", "l": "\"jasmonoyl-L-amino acid hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20461", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.344", "l": "\"ornithine lipid N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130619", "l": "TGN-lysosomal vesicle coat assembly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25100", "l": "ADP + UTP => ATP + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51227", "l": "2 Fe(III)-[cytochrome c] + S-sulfanyl-L-cysteinyl-[SoxY protein] + thiosulfate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71360", "l": "17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) => 17beta-estradiol 17-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19864", "l": "a 16alpha-hydroxysteroid + NAD(+) <=> a 16-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71707", "l": "H(+)(out) + L-phenylalanyl-L-phenylalanine(out) = H(+)(in) + L-phenylalanyl-L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174967", "l": "NAT2 acetylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5622134", "l": "CRABP1 binds atRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15178", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.54027469738007", "identifiers": [{"i": "GO:0016702", "l": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73962", "l": "2-methoxy-4-vinylphenol + H(+) + NADH <=> 4-ethyl-2-methoxyphenol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008389", "l": "coumarin 7-hydroxylase activity", "d": ["Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437230", "l": "L1-FGFR cis-heterodimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805943", "l": "S100A1 binds TLR4:LY96 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1467466", "l": "ABCA4 mediates atRAL transport (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170674", "l": "Dissociation of the Gi alpha:G olf complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877902", "l": "Activated AR binds RUNX2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49564", "l": "D-sedoheptulose 7-phosphate = 2-epi-valiolone + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.155", "l": "\"2-epi-valiolone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21681", "l": "(2S)-2-hydroxyphytanate + O2 => 2-oxophytanate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647994", "l": "RAS proteins are depalmitoylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50408", "l": "1-(2-aminophenyl)decane-1,3-dione = 2-heptyl-4(1H)-quinolone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35156", "l": "(S)-4,5-dihydroxypentane-2,3-dione => (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17851", "l": "(2E)-butenoyl-CoA + H2O => (3R)-3-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32389", "l": "dihydrocarvone + H(+) + NADH => dihydrocarveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676589", "l": "RANKL,sRANKL trimer binds RANK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58423", "l": "NADP(+) + prenol <=> 3-methyl-2-butenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352961", "l": "dihydroxyacetone phosphate + glyceraldehyde 3-phosphate <=> fructose 1,6-bisphosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070041", "l": "rRNA (uridine-C5-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17619", "l": "glutathione + leukotriene A4 => leukotriene C4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164617", "l": "Elongation of Extended Telomeric Chromosome End (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937656", "l": "IL10 negatively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12020", "l": "a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624125", "l": "Formation of the BBSome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392834", "l": "Activation of EPACs by cAMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23066", "l": "an aldehyde + FMN + 2 H(+) + H2O + sulfite => an alkanesulfonate + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944214", "l": "Association of procollagen type I (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047939", "l": "L-glucuronate reductase activity", "d": ["Catalysis of the reaction: L-gulonate + NADP+ = D-glucuronate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62766", "l": "4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25117", "l": "H2O + L-lysine + NAD(+) = (S)-2-amino-6-oxohexanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69152", "l": "Removal of remaining Flap (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78573", "l": "(2E)-docosenoyl-CoA + H2O2 => docosanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36080", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50236", "l": "O2 + pregnenolone + reduced [NADPH--hemoprotein reductase] = 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73973", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+) => a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44668", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol = 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.47", "l": "\"teichoic acid ribitol-phosphate polymerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71190", "l": "3-hydroxy-L-kynurenine(out) + L-tryptophan(in) <=> 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093342", "l": "SDC2 multimerises (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031691", "l": "alpha-1A adrenergic receptor binding", "d": ["Binding to an alpha-1A adrenergic receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62229", "l": "(E)-ascladiol + A => AH2 + patulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37614", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193650", "l": "p75NTR binds to NADE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036380", "l": "UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33764", "l": "a (2E)-enoyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61229", "l": "H2O + L-histidine + O2 => 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25836", "l": "3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D-glucuronate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.22", "l": "\"3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58404", "l": "hexan-1-ol + NADP(+) = H(+) + hexanal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29663", "l": "H(+)(in) + xanthine(in) = H(+)(out) + xanthine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016871", "l": "cycloartenol synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14488", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 10-epi-juneol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022405", "l": "ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67932", "l": "ATP + desmosterol(in) + H2O = ADP + desmosterol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202203", "l": "Recruitment of PI3K to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097434", "l": "succinate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + H+(out) = succinate(in) + H+(in)."], "t": []}, {"i": "RHEA:29303", "l": "2 H(+)(in) + succinate(in) = 2 H(+)(out) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11534", "l": "glyoxylate + H2O2 + NH4(+) => glycine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.43", "l": "\"beta-L-rhamnosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793217", "l": "Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1008200", "l": "NFE2 binds the beta globin locus control region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959462", "l": "SAMD8 transfers phosphatidyl from PE onto C16DH CER (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37958", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate <=> (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070039", "l": "rRNA (guanosine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696564", "l": "USP25 deubiquitinates DDX58 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27774", "l": "2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714481", "l": "RAC2 binds effectors at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29896", "l": "ATP + H2O + L-glutamine(out) => ADP + H(+) + L-glutamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052914", "l": "16S rRNA (guanine(1207)-N(2))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62602", "l": "5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62714", "l": "H2O + NADP(+) + stemphyloxin I => betaenone C + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444433", "l": "Cho transports from the extracellular space to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839073", "l": "HTRA2 binds NDUFA13 (GRIM-19) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067640", "l": "IL6 binds IL6R-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.30", "l": "\"acyl-lipid (8-3)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696958", "l": "USP44 deubiquitinates CDC20 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706293", "l": "Active FLT3 binds to CBL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74440", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) => a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23642", "l": "CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate => 1-aminocyclopropane-1-carboxylate + L-ascorbate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174224", "l": "Dissociation of Cdc20 from APC/C complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53372", "l": "5,6-dihydrouridine(17) in tRNA + NAD(+) = H(+) + NADH + uridine(17) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140560", "l": "xylosyl alpha-1,3-xylosyltransferase activity", "d": ["Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55498", "l": "ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050551", "l": "myrcene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = diphosphate + myrcene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9611277", "l": "P2RY12 binds P2RY12 antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.80", "l": "\"long-chain fatty acid omega-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210872", "l": "Trans-phosphorylation of Tie2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34614", "l": "N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose <=> H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24166", "l": "[thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein] => [thioredoxin]-disulfide + H2O + L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76462", "l": "(E)-sinapyl alcohol + A <=> (E)-sinapaldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982703", "l": "PKC binds active G alpha (z) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10926", "l": "trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide => cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34013", "l": "ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2 => 5-dehydroepisterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39154", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyoctadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010357", "l": "homogentisate solanesyltransferase activity", "d": ["Catalysis of the reaction: all-trans-nonaprenyl diphosphate + H+ + homogentisate = 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate. 2-methyl-6-solanyl-1,4-benzoquinonone is also known as 2-methyl-6-solanesylplastoquinol and all-trans-nonaprenyl diphosphate as solanesyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38633", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23885", "l": "nicotinamide + S-adenosyl-L-methionine => 1-methylnicotinamide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928656", "l": "gamma-secretase cleaves EPHB2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373732", "l": "Nephrin trans-homophilic interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68263", "l": "D-serine(in) + Na(+)(in) <=> D-serine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9686088", "l": "CASP3 cleaves GSDMD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74989", "l": "erythrostominone(out) => erythrostominone(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70020", "l": "O2 + reduced [NADPH--hemoprotein reductase] + typhasterol => 7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28152", "l": "CoA + H(+) + N(1)-acetylspermidine => acetyl-CoA + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5691131", "l": "CANDI binds CUL1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51298", "l": "a quinol + L-methionyl-(R)-S-oxide-[protein] => a quinone + H2O + L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102416", "l": "quercetin gentiotrioside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-gentiotrioside + UDP-alpha-D-glucose = quercetin-3-gentiotetraside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684052", "l": "PIAS4 SUMOylates MDC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15461", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23299", "l": "aceneuramate <=> N-acetyl-D-mannosamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798474", "l": "S100A8:S100A9 binds Zn2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55828", "l": "cortisol + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50373", "l": "an N-acylsphingoid base 1-phosphate(in) => an N-acylsphingoid base 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52612", "l": "3-(methylsulfanyl)propanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-(methylsulfanyl)acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.99.41", "l": "\"3-(methylsulfanyl)propanoyl-CoA 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61099", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-eriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21610", "l": "2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine => isoliquiritigenin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56907", "l": "an acyl-AMP + CoA <=> AMP + an acyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32647", "l": "erythromycin C + S-adenosyl-L-methionine = erythromycin A + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65812", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 = A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA", "d": [], "t": []}, {"i": "EC:1.14.99.69", "l": "\"tRNA 2-(methylsulfanyl)-N(6)-isopentenyladenosine(37) hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72718", "l": "(R)-dihydrolipoate + ATP + H(+) <=> diphosphate + N(6)-[(R)-dihydrolipoyl]-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008445", "l": "D-aspartate oxidase activity", "d": ["Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61326", "l": "3beta-hydroxycostunolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68983", "l": "NADP(+) + tauroursodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42287", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672980", "l": "Dissociation of RAS:RAF complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56800", "l": "apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide = cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24636", "l": "H2 + NAD(+) = H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607738", "l": "SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51699", "l": "desmethylxanthohumol + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + xanthohumol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35793", "l": "H(+) + kanamycin X + UDP => 2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10573", "l": "vinylacetyl-CoA => (2E)-butenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821931", "l": "BOD1L1 binds SET1A complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67501", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54028", "l": "a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.22", "l": "\"carbazole 1,9a-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29081", "l": "pyruvate + ubiquinol-8 => (R)-lactate + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25952", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate", "d": [], "t": []}, {"i": "EC:2.2.1.10", "l": "\"2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40370", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.30", "l": "\"flavin reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265858", "l": "Activation of ATR by interaction with RAD9-TopBP1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.93", "l": "\"proprotein convertase 1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31766", "l": "a 2-oxocarboxylate + L-methionine <=> 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725345", "l": "NPM1-ALK-dependent JUNB translation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24639", "l": "H2 + NAD(+) <=> H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72691", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381109", "l": "IRE1 binds IRE1 forming dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852010", "l": "BTNL2 binds activated T cells surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034799", "l": "dihydride TNP tautomerase activity", "d": ["Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694442", "l": "CNIH2,3 bind GRIA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.15", "l": "\"anhydrosialidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001856", "l": "complement component C5a binding", "d": ["Binding to a C5a product of the complement cascade."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139917", "l": "tBID activates BAX protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20097", "l": "D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.8", "l": "\"mannonate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54844", "l": "H(+) + hexan-3-one + NADPH + O2 = ethyl butanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74165", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67865", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49737", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate => CO2 + deoxyviolacein + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77641", "l": "adenosine 5'-phosphosulfate + phosphate => 3'-phosphoadenylyl sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46534", "l": "a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12586", "l": "16,17-didehydroprogesterone + H2O => 16alpha-hydroxyprogesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008951", "l": "palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity", "d": ["Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981610", "l": "Neuroglobin binds oxygen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47604", "l": "a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GP1calpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990610", "l": "acetolactate synthase regulator activity", "d": ["Binds to and modulates the activity of acetolactate synthase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71597", "l": "2-oxoglutarate(in) + succinate(out) => 2-oxoglutarate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25885", "l": "carbamoyl phosphate + N(2)-succinyl-L-ornithine => H(+) + N(2)-succinyl-L-citrulline + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55717", "l": "(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O => (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72916", "l": "D-fructopyranose(out) + Na(+)(out) => D-fructopyranose(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55748", "l": "coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.8.98.5", "l": "\"H2:CoB-CoM heterodisulfide,ferredoxin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42310", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420977", "l": "Ca permeable AMPA receptor ligand binding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68064", "l": "a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17130", "l": "ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide => 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047586", "l": "5'-acylphosphoadenosine hydrolase activity", "d": ["Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54658", "l": "(2E)-geraniol => linalool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2995334", "l": "COX15 transforms heme O to heme A (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54988", "l": "4 e(-) + 4 H(+)(in) + O2(in) = 2 H2O(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14029", "l": "A + H2O + selenite = AH2 + selenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53204", "l": "17beta,19-dihydroxy-3-oxo-5alpha-androstanone + O2 + reduced [NADPH--hemoprotein reductase] = 17beta-hydroxy-3,19-dioxo-5alpha-androstanone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51501", "l": "ATP + N-acetyl-D-muramate => ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380311", "l": "Recruitment of Plk1 to centrosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75236", "l": "L-fucono-1,5-lactone => L-fucono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50231", "l": "FADH2 + O2 + resorcinol <=> benzene-1,2,4-triol + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372529", "l": "Release of acetylcholine at the synapse (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167408", "l": "The high affinity receptor complex binds to G-protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69127", "l": "Formation of the Flap Intermediate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18409", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53212", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420265", "l": "AMY1-3 bind IAPP(34-70) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49845", "l": "(-)-dehydrodiconiferyl acid + a quinone => (-)-dehydrodiconiferyl acid ketone + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140620", "l": "DNA strand exchange inhibitor activity", "d": ["Binds to and stops, prevents or reduces a DNA strand exchange activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983285", "l": "RAD51B binds RAD51C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050359", "l": "tropomyosin kinase activity", "d": ["Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40088", "l": "22-hydroxydocosanoate + NAD(+) => 22-oxodocosanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53897", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48341", "l": "a medium chain fatty acid + ATP + CoA => a medium-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67057", "l": "chermesin D + S-adenosyl-L-methionine => chermesin D methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44118", "l": "CoA + eicosanyl hexadecanoate => eicosan-1-ol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15668", "l": "aldehydo-D-glucose + L-lysyl-[protein] <=> H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54285", "l": "H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-octadecanoylsphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5606996", "l": "Soluble PROCR binds activated protein C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682598", "l": "ATM phosphorylates HERC2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40621", "l": "2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+) => H2O + tridodecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55002", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77640", "l": "3'-phosphoadenylyl sulfate + H2O => adenosine 5'-phosphosulfate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0033721", "l": "aldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64784", "l": "S-ethyl-L-cysteine = 2-aminoprop-2-enoate + ethanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45843", "l": "(3R)-3-hydroxydecanoyl-CoA + NADP(+) <=> 3-oxodecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33429", "l": "bacillithiol + H2O => (S)-malyl alpha-D-glucosaminide + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11025", "l": "ATP + NH4(+) => ADP + 2 H(+) + phosphoramidate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78728", "l": "(3S)-hydroxydocosanoyl-CoA + NAD(+) => 3-oxodocosanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43723", "l": "juvenile hormone III carboxylate + S-adenosyl-L-methionine <=> juvenile hormone III + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55065", "l": "4-methylpentanoyl-CoA + H2O => 4-methylpentanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71932", "l": "fumarate(out) + 3 Na(+)(out) => fumarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730407", "l": "SOX10 and PAX3 bind the MITF promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382058", "l": "Nck binds to the active PDGF receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432361", "l": "Cytosolic PER is degraded by the 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70790", "l": "H(+)(in) + L-citrulline(in) + L-ornithine(out) <=> H(+)(out) + L-citrulline(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34868", "l": "ATP + CoA + thiophene-2-carboxylate => AMP + diphosphate + thiophene-2-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65772", "l": "2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24322", "l": "an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632738", "l": "DDIT4 binds 14-3-3 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72890", "l": "O2 + polyporic acid + reduced [NADPH--hemoprotein reductase] <=> ascocorynin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55467", "l": "11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741386", "l": "RIP2 induces K63-linked ubiquitination of NEMO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141367", "l": "Myristoylation of tBID by NMT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13450", "l": "2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74093", "l": "ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63563", "l": "angiotensin I + H2O <=> angiotensin II + L-histidyl-L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76617", "l": "acetyl-CoA + H(+) + hydrogencarbonate + NADH => 3-oxopropanoate + CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74275", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid A = a 2-acyl-sn-glycero-3-phosphocholine + a hepta-acyl lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74982", "l": "(3R)-3-isocyanylbutanoate + ATP + H(+) <=> (3R)-3-isocyanylbutanoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0052738", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a quinone or similar compound."], "t": []}, {"i": "EC:1.2.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62860", "l": "acetyl-CoA + 7 H(+) + 7 malonyl-CoA = 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45758", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine => (6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27975", "l": "6-carboxy-5,6,7,8-tetrahydropterin + H(+) => 7-carboxy-7-deazaguanine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50145", "l": "ethyl (9Z)-hexadecenoate + H2O => (9Z)-hexadecenoate + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69880", "l": "6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase] => castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139920", "l": "Translocation of tBID to mitochondria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66915", "l": "avenanthramide C + S-adenosyl-L-methionine <=> avenanthramide B + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31430", "l": "(2E,6E)-farnesyl diphosphate <=> (1S,5S,6R)-alpha-bergamotene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31393", "l": "all-trans-4,4'-diapolycopene + 4 FADH2 => 15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47775", "l": "a guanosine in 21S rRNA + S-adenosyl-L-methionine <=> a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690873", "l": "ACO1 binds 4Fe-4S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56080", "l": "[Rab1 protein]-L-serine + CDP-choline = [Rab1 protein]-O-phosphocholine-L-serine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17570", "l": "(R)-reticuline + NADP(+) => 1,2-dehydroreticuline + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.6", "l": "\"catalase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332359", "l": "Active calmodulin binds CAMK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71145", "l": "(E)-caffeoylpyruvate + CO2 + hnu => 3-hydroxyhispidin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58339", "l": "a 4-hydroxynonen-1-ol + NADP(+) <=> a 4-hydroxynonenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18745", "l": "2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.17.3.4", "l": "\"juglone 3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000006", "l": "high-affinity zinc transmembrane transporter activity", "d": ["Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29542", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52509", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008285", "l": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33284", "l": "2-hydroxycyclohexan-1-one + NADPH + O2 => 6-oxohexanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24949", "l": "3-hydroxy-3-methylglutarate + malonyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202702", "l": "CD177 binds PECAM-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39811", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35006", "l": "L-fucose(in) <=> L-fucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682020", "l": "MRN complex binds shortened telomeres (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36970", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20610", "l": "2-dehydro-3-deoxy-D-arabinonate => glycolaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019782", "l": "ISG15 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11595", "l": "dihydromonacolin L-[lovastatin nonaketide synthase] + H2O <=> dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53429", "l": "a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] => a thymidine in DNA + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73536", "l": "CDP(out) + UTP(in) => CDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855190", "l": "I(1,4,5)P3 transports from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40013", "l": "diphosphate + manool => (+)-copalyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336184", "l": "GPR37L binds prosaposin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59540", "l": "(2R)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57953", "l": "H(+) + NADH + O2 + phenol => catechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32849", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987214", "l": "p-STAT3 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10077", "l": "H2O + lactose => beta-D-galactose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59104", "l": "a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate = a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983147", "l": "Release of E3 from polyubiquitinated substrate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9619376", "l": "CAMK1 binds calmodulin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.23", "l": "\"S-methyl-5-thioribulose 1-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204549", "l": "Caveolin-1 binds Basigin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047016", "l": "cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59915", "l": "(E)-4-hydroxynon-2-enal + H2O + NADP(+) <=> (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73639", "l": "CTP(out) + ITP(in) = CTP(in) + ITP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649856", "l": "Oxidative damage to the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604763", "l": "Autocatalytic activation of MMP7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24382", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet) => (6R)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39621", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+) => (2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60604", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2247511", "l": "STAB2:ligand is endocytosed (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77458", "l": "formylthiophene + hydrogen cyanide <=> (2R)-2-hydroxy-2-(thiophen-2-yl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69798", "l": "D-aspartyl-tRNA(Asp) + H2O <=> D-aspartate + H(+) + tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17883", "l": "D-glucosamine + sulfate => H2O + N-sulfo-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627089", "l": "CASP9 is phosphorylated at T412 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534378", "l": "Hv1 Mediated H+ Permeability (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602892", "l": "Defective GCLC does not ligate L-Glu to L-Cys (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71899", "l": "3',5'-cyclic GMP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54040", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (3E,7E)-dolathalia-3,7,11-triene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.168", "l": "\"dolathalia-3,7,11-triene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77083", "l": "O2 + pre-flavunoidine + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-pre-flavunoidine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25211", "l": "acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77800", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)glycine + O2 => 2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]acetate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658438", "l": "SPRED dimer binds NF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49626", "l": "ADP + D-erythritol 1-phosphate + H(+) => ATP + erythritol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-921155", "l": "p-STAT5 dissociates from the receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.352372097681226", "identifiers": [{"i": "GO:0016708", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52606", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+) => 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034189", "l": "very-low-density lipoprotein particle binding", "d": ["Binding to a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58706", "l": "rifampicin ortho-naphthoquinone carboxamide => rifampicin hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.43", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190682", "l": "Connexin synthesis (generic) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449855", "l": "IL10 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852337", "l": "GTSE1 binds TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749505", "l": "LRRC14 binds IKBKB and CHUK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51422", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH => a (2S,3S)-flavan-3-ol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689111", "l": "PARK2 autoubiquitinates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160101", "l": "tRNA (guanine(10)-N2)-dimethyltransferase activity", "d": ["Catalysis of the reaction: guanosine(10) in tRNA + 2 S-adenosyl-L-methionine = 2 H+ + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34155", "l": "acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": [], "t": []}, {"i": "EC:2.3.1.202", "l": "\"UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25778", "l": "scyllo-inosine => scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0051003", "l": "ligase activity, forming nitrogen-metal bonds, forming coordination complexes", "d": ["Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex."], "t": []}, {"i": "EC:6.6.1.-", "l": "\"Forming coordination complexes\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23634", "l": "2-oxoglutarate + CO2 + NADH => D-threo-isocitrate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52427", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73225", "l": "(3S)-citramalate(out) + sulfate(in) => (3S)-citramalate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66053", "l": "indole-3-pyruvate + L-kynurenine => H2O + kynurenate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004933", "l": "mating-type a-factor pheromone receptor activity", "d": ["Combining with the mating-type a-factor pheromone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54006", "l": "(11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210430", "l": "Release of L-Glutamate at the synapse (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446364", "l": "Migfilin interacts with VASP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689317", "l": "Formation of the pre-incision complex in GG-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.25", "l": "\"4-alpha-glucanotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40451", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050306", "l": "sucrose 1F-fructosyltransferase activity", "d": ["Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65785", "l": "2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45165", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9824897", "l": "p-S-TBK1 phosphorylates OPTN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14022", "l": "AH2 + ecdysone + O2 => 20-hydroxyecdysone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109860", "l": "MAP2K1 phosphorylates MAPK3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45811", "l": "galactarate <=> (2S,3R)-dihydroxy-5-oxohexanedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69003", "l": "3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine <=> 3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59233", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => diphosphate + hydropyrenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53023", "l": "a plastoquinone + an L-alpha-amino acid + H2O <=> a 2-oxocarboxylate + a plastoquinol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008813", "l": "chorismate lyase activity", "d": ["Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106144", "l": "fraxetin 5-hydroxylase activity", "d": ["Catalyzes the reaction fraxetin+ NAD(P)H + 02= sideretin + NAD(P)(+) + H20."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27973", "l": "D-maltotriose + H2O <=> alpha-D-glucose + D-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23706", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate => GTP + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12523", "l": "L-dopa <=> (E)-caffeate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16925", "l": "(E)-caffeoyl-CoA + S-adenosyl-L-methionine = (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.104", "l": "\"caffeoyl-CoA O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71221", "l": "2 Na(+)(in) + nitrate(in) => 2 Na(+)(out) + nitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29555", "l": "H2O + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16413", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] = L-lysyl-[glycine-cleavage complex H protein] + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}, {"i": "EC:2.3.1.200", "l": "\"lipoyl amidotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75672", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate => 14,15-epoxy-12-hydroxy-(10E,17Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44557", "l": "4-hydroxybenzoate + all-trans-hexaprenyl diphosphate => 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166542", "l": "beta-NGF dimer binds to TrkA receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852019", "l": "MET bound PI3K generates PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34395", "l": "L-phenylalanine = L-beta-phenylalanine", "d": [], "t": []}, {"i": "EC:5.4.3.10", "l": "\"phenylalanine aminomutase (L-beta-phenylalanine forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71164", "l": "HGD dioxygenates homogentisate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46355", "l": "(2E)-decenoyl-CoA + H2O <=> 3-hydroxydecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69677", "l": "(S)-eriodictyol + beta-D-glucose => eriodictyol-7-O-beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76344", "l": "(2S)-2-isopropylmalate(in) + sulfate(out) => (2S)-2-isopropylmalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033968", "l": "glutaryl-7-aminocephalosporanic-acid acylase activity", "d": ["Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13074", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O => guanosine 3',5'-bis(diphosphate) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32539", "l": "(2E)-geranyl diphosphate = (+)-car-3-ene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.107", "l": "\"(+)-car-3-ene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855186", "l": "I(1,3,4,5)P4 transports from the cytosol to the ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060182", "l": "apelin receptor activity", "d": ["Combining with the peptide apelin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191303", "l": "FDPS dimer transfers IPPP to GPP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35732", "l": "sn-glycerol 3-phosphate + tetradecanoyl-CoA => 1-tetradecanoyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3899291", "l": "SUMOylation of EP300 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.24", "l": "\"cathepsin T\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16727", "l": "a phosphatidylglycerol + phosphate => a phosphatidylglycerol phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33273", "l": "a 1,2-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2428922", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76961", "l": "2-methylbutanal + H(+) + NADPH + NH4(+) => 2-methylbutanamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43819", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44739", "l": "acetyl-CoA + dihydroxyacetone phosphate <=> 3-hydroxy-2,4-dioxopentyl phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37136", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate => 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204773", "l": "Interaction of Tie2 and Grb7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045480", "l": "galactose oxidase activity", "d": ["Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0016215", "l": "acyl-CoA desaturase activity", "d": ["Catalysis of the reaction: AH2 + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + A + 2 H2O."], "t": []}, {"i": "RHEA:25416", "l": "AH2 + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211968", "l": "CYP2W1 oxidises INDOL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048244", "l": "phytanoyl-CoA dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + O2 + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO2 + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46999", "l": "6-hydroxy-N-methylmyosmine + H2O <=> 6-hydroxypseudooxynicotine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16045", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389963", "l": "alpha-tubulin:GTP:Cofactor B  +Cofactor E ->  alpha-tubulin:GTP: Cofactor E +Cofactor B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080097", "l": "L-tryptophan:pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: L-tryptophan + pyruvate = 3-(indol-3-yl)pyruvate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32753", "l": "choline(in) => choline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39246", "l": "(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339535", "l": "CPTP transports C1P from plasma membrane to Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209278", "l": "Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678327", "l": "MIOX oxidises Ins to GlcA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987120", "l": "JAK1 binds IFNLR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31908", "l": "(S)-norcoclaurine + S-adenosyl-L-methionine => (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617927", "l": "FOXO4 binds ATXN3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848829", "l": "CBL autoubiquitinates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5631941", "l": "SESN1,2,3 bind AMPK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12207", "l": "dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75341", "l": "chloride(in) + nitrate(out) => chloride(out) + nitrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944078", "l": "EGR1 binds the PTEN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28435", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP] => ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31425", "l": "(-)-alpha-cedrene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018756", "l": "RHOH binds GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209365", "l": "Phosphorylated STAT92E dimer transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3785768", "l": "MRN complex binds DNA double strand breaks (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67558", "l": "adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + glycocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69203", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate <=> ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0002061", "l": "pyrimidine nucleobase binding", "d": ["Binding to a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187828", "l": "Translocation of p21 to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627891", "l": "Defective SLC27A4 does not transport LCFAs from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44845", "l": "(R)-carnitine + eicosanoyl-CoA => CoA + O-eicosanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043812", "l": "phosphatidylinositol-4-phosphate phosphatase activity", "d": ["Catalysis of the reaction: phosphatidyl-1D-myo-inositol-4-phosphate + H2O = phosphatidyl-1D-myo-inositol + phosphate."], "t": []}, {"i": "RHEA:55652", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814555", "l": "Integrator complex processes the 3' end of snRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63323", "l": "a glycerophospholipid(in) + ATP + H2O <=> a glycerophospholipid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29693", "l": "alpha-D-glucose 1-phosphate + alpha-maltotriose => alpha-maltotetraose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24793", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate", "d": [], "t": []}, {"i": "EC:4.3.2.10", "l": "\"imidazole glycerol-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483174", "l": "PE is methylated to PC by PEMT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.56", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017044", "l": "melanocyte-stimulating hormone activity", "d": ["The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49196", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = 25-hydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26387", "l": "(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal => all-trans-8'-apo-beta-carotenal + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9707690", "l": "BACH1 binds MAFK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77488", "l": "4-methylpentan-2-one + hydrogen cyanide => (2S)-2-hydroxy-2,4-dimethylpentanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31978", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin <=> 7beta-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004984", "l": "olfactory receptor activity", "d": ["Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44091", "l": "ATP + CoA + heptanoate <=> AMP + diphosphate + heptanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40389", "l": "1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61203", "l": "acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247844", "l": "WNT ligands traffic to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56477", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 => (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70430", "l": "H2O + phenylacetyl-CoA <=> 2-phenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71686", "l": "2 H(+)(out) + L-aspartyl-glycine(out) <=> 2 H(+)(in) + L-aspartyl-glycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448629", "l": "IL33 binds IL1RL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044323", "l": "retinoic acid-responsive element binding", "d": ["Binding to a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44849", "l": "(9Z)-tetradecenoyl-CoA + (R)-carnitine => CoA + O-(9Z)-tetradecenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71432", "l": "3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) => 3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218952", "l": "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13131", "l": "4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP => cis-4-coumarate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52328", "l": "L-arginine + O2 + reduced [flavodoxin] = H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62183", "l": "H2O + peregrinol diphosphate <=> diphosphate + viteagnusin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693593", "l": "D-loop extension by DNA polymerases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12486", "l": "a ribonucleoside + phosphate => a ribonucleoside 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109639", "l": "Formation of the closed pre-initiation complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52660", "l": "an L-alpha-amino acid + ATP + holo-[ACP] = AMP + an L-alpha-aminoacyl-[ACP] + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.n2", "l": "\"amino acid--[acyl-carrier-protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620456", "l": "sGC stimulators bind sGC:NO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749647", "l": "CES2 hydrolyzes ASA- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645134", "l": "p-STAT5 dissociates from activator:STAT5 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645481", "l": "TIFA oligomerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51965", "l": "2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50025", "l": "dodecanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.-", "l": "\"Ether hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448627", "l": "Interleukin-35 translocates from the ER lumen to the extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198621", "l": "AKT phosphorylates caspase-9 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8857686", "l": "FITM1, FITM2 bind TAGs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15460", "l": "cis-1,2-dihydrobenzene-1,2-diol + NAD(+) <=> catechol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186780", "l": "Degradation of Ub-SMAD7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9846332", "l": "FUT1,2 transfer fucose to gangliosides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38700", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20599", "l": "H(+) + L-cystine + NADH => 2 L-cysteine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656891", "l": "OPN1SW binds 11cRAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186778", "l": "SHP2 binds to the active receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.46", "l": "\"gentamicin 2''-nucleotidyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12014", "l": "ADP + H(+) + thiamine phosphate => ATP + thiamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354087", "l": "Recruitment of GRB2 to p-PTK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77460", "l": "3-formylthiophene + hydrogen cyanide => (2S)-2-hydroxy-2-(thiophen-3-yl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75891", "l": "Abortive Initiation After Second Transition (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75813", "l": "acetoacetate(in) + Na(+)(in) => acetoacetate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.235", "l": "\"lipopolysaccharide core heptose(I) kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9758529", "l": "SARS-CoV-2 N binds MASP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69688", "l": "genistein 7-O-beta-D-glucoside + H2O => beta-D-glucose + genistein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68551", "l": "O2 + psoralen + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5444511", "l": "Formation of MSH2:MSH3 Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46529", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63547", "l": "H2O + kinetensin <=> kinetensin-(1-8) + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23937", "l": "D-gluconate + NADP(+) => 5-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70214", "l": "2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose <=> (S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0033677", "l": "DNA/RNA helicase activity", "d": ["Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64639", "l": "benzoyl-CoA + butan-1-ol <=> butyl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10809", "l": "(S)-2-hydroxypropylphosphonate + H2O2 => (1R,2S)-epoxypropylphosphonate + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0030561", "l": "RNA 2'-O-ribose methylation guide activity", "d": ["Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77757", "l": "[4-(deca-1,8-diyl)-2,5-dioxo-2,5-dihydro-3-furanyl]acetate + 2 H2O => (4E,11E)-2-hydroxytrideca-4,11-dien-1,2,3-tricarboxylate + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68030", "l": "H2O2 + urate => 6,8-dihydroxypurine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21303", "l": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51145", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 => (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030734", "l": "polysaccharide O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77479", "l": "hexan-2-one + hydrogen cyanide = (2S)-2-hydroxy-2-methylhexanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50087", "l": "ATP + H2O + taurolithocholate 3-sulfate(in) <=> ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982645", "l": "GRKs bind ADRB2:Catecholamine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30347", "l": "ATP + IDP = ADP + ITP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662615", "l": "MT1X binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827864", "l": "Expression of CBFA2T2 in primordial germ cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77572", "l": "a 1-acylglycerol + an acyl-CoA => a 1,3-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14159", "l": "diphosphate + phosphate => H2O + triphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22015", "l": "precorrin-4 + S-adenosyl-L-methionine <=> precorrin-5 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66615", "l": "N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA <=> methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29296", "l": "aldehydo-D-galacturonate(out) + H(+)(out) => aldehydo-D-galacturonate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395784", "l": "Nascent CMs transform into mature CMs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75286", "l": "decanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxydecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52891", "l": "N-phenylhydroxylamine + NADP(+) <=> H(+) + NADPH + nitrosobenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21079", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 <=> CO2 + succinate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139919", "l": "Translocation of BIM to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58541", "l": "2 L-ascorbate + N-dodecanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-dodecanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52553", "l": "3-dehydro-L-erythronate + ATP => 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64833", "l": "3-hydroxybenzyl alcohol + benzoyl-CoA => 3-hydroxy-benzyl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32745", "l": "acetate + H(+) + L,L-cystathionine => L-homocysteine + O-acetyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453183", "l": "p-Y348-SYK dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.183", "l": "\"taxoid 2alpha-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.943982515046912", "identifiers": [{"i": "GO:0004386", "l": "helicase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39507", "l": "3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68271", "l": "dUMP + formaldehyde + H(+) + NADPH <=> dTMP + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18031", "l": "2 ADP + carbamoyl phosphate + 2 H(+) + phosphate => 2 ATP + hydrogencarbonate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71096", "l": "2 Na(+)(out) + pregnenolone sulfate(out) => 2 Na(+)(in) + pregnenolone sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26300", "l": "1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH <=> 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74127", "l": "peonidin + UDP-alpha-D-galactose = peonidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247513", "l": "STAB1:ligand is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47912", "l": "6-deoxy-6-sulfo-D-gluconate = 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.162", "l": "\"6-deoxy-6-sulfo-D-gluconate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005316", "l": "high-affinity phosphate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction:phosphate(out) + Na+(out) = phosphate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74623", "l": "AMP(in) + UMP(out) = AMP(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17197", "l": "2 3-(4-hydroxyphenyl)pyruvate + O2 = 2 4-hydroxyphenylacetate + 2 CO2", "d": [], "t": []}, {"i": "EC:1.2.3.13", "l": "\"4-hydroxyphenylpyruvate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30860", "l": "dITP + H2O => dIDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51979", "l": "an L-N-hydroxypolyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> an L-N,N-dihydroxypolyhomomethionine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9844860", "l": "ST3GAL5 transfers NeuNAc to ceramides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58506", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15056", "l": "(6R)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54905", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH => (9Z)-hexadecenoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47139", "l": "ATP + CoA + lithocholate <=> AMP + diphosphate + lithocholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49455", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H2O <=> 6-sulfo-alpha-D-quinovose + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019909", "l": "[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity", "d": ["Binds to and modulates of the activity of [pyruvate dehydrogenase (lipoamide)] phosphatase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009558", "l": "IL34 dimer binds SDC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52804", "l": "(2E,6E)-farnesyl diphosphate = (+)-eremophilene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.164", "l": "\"(+)-eremophilene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202325", "l": "Recruitment of Gads to LAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374680", "l": "L1 trans-homophilic interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534096", "l": "METAP1/2 demethylates GNAT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48692", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20182", "l": "alpha-D-mannose derivative + UDP-alpha-D-glucose => 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61805", "l": "ATP + H(+) + L-alanine => diphosphate + L-alanyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71609", "l": "(S)-malate(out) + phosphate(in) => (S)-malate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50942", "l": "cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe) => L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50917", "l": "a carboxylate + ATP + H(+) + NADPH => AMP + an aldehyde + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.24", "l": "\"nucleoside phosphoacylhydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31674", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693347", "l": "CRYM reduces P2C to PPCA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368065", "l": "Expression of NPAS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79134", "l": "cholate + L-alanine <=> H2O + L-alanocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77777", "l": "CoA + H(+) + N(6)-acetyl-N(6)-methyl-L-lysyl-[histone] => acetyl-CoA + N(6)-methyl-L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38695", "l": "a cardiolipin(in) = a cardiolipin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509838", "l": "ITPA hydrolyses dITP to dIMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42931", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16277", "l": "H2O + indole-3-acetaldehyde + O2 = (indol-3-yl)acetate + H(+) + H2O2", "d": [], "t": []}, {"i": "EC:1.2.3.7", "l": "\"indole-3-acetaldehyde oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004134", "l": "4-alpha-glucanotransferase activity", "d": ["Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64942", "l": "dGMP + H(+) + phosphate => dGDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-168400", "l": "iE-DAP elicits a NOD1 response (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65172", "l": "(3Z,5E)-dodecadienoyl-CoA + H2O = (3Z,5E)-dodecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852324", "l": "GTSE1 binds PLK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043739", "l": "G/U mismatch-specific uracil-DNA glycosylase activity", "d": ["Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil and leaving an apyrimidinic (AP) site."], "t": []}, {"i": "EC:3.2.2.28", "l": "\"double-stranded uracil-DNA glycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45626", "l": "AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein] => ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707683", "l": "PGRMC2 binds Hemes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59850", "l": "(S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+) => (2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482778", "l": "CL is hydrolyzed to MLCL by PLA2G6 (IM) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225957", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45241", "l": "a (3E,5Z)-dienoyl-CoA => a (2E,4E)-(5,6-saturated)-dienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33096", "l": "chorismate + inosine + phosphoenolpyruvate => futalosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20017", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2 = 5,10-methylenetetrahydromethanopterin + H(+)", "d": [], "t": []}, {"i": "EC:1.12.98.2", "l": "\"5,10-methenyltetrahydromethanopterin hydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373745", "l": "SDK1 homophillic interaction (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17698", "l": "pyridine + thiamine => 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8979071", "l": "KDM6B binds iron (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70439", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2 = a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817575", "l": "ERO1B oxidizes P4HB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622630", "l": "FOXO3,FOXO4,(FOXO1) bind BCL6 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73295", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine = 7,8-dihydroxy-4'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74352", "l": "2 (S)-lactate(in) + prostaglandin E3(out) => 2 (S)-lactate(out) + prostaglandin E3(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74344", "l": "O-hexanoyl-(R)-carnitine(in) => O-hexanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801109", "l": "CHM binds RGGT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19074", "l": "ATP + L-seryl-[I-kappa-B protein] => ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64698", "l": "benzaldehyde + H(+) + NADH => benzyl alcohol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59068", "l": "demethyldeoxyspectinabilin + S-adenosyl-L-methionine = deoxyspectinabilin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31810", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-guaiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445705", "l": "Release Of ADP From Myosin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39183", "l": "3-oxodocosanoyl-CoA + H(+) + NADPH = (3R)-hydroxydocosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68840", "l": "(2Z,6E)-farnesyl diphosphate = (6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18350", "l": "ATP + L-aspartate + tRNA(Asx) => AMP + diphosphate + L-aspartyl-tRNA(Asx)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641111", "l": "Parkin transfers Ub to misfolded proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78446", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1,2-diacylglycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9646468", "l": "mTORC1 binds RHEB:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201443", "l": "Type II receptor phosphorylates type I receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14221", "l": "H2O + monomethyl sulfate = H(+) + methanol + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.16", "l": "\"monomethyl-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72967", "l": "4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) = 4-methyl-2-oxopentanoate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61852", "l": "campesterol + UDP-alpha-D-glucose = campesteryl 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41564", "l": "aklavinone + dTDP-beta-L-rhodosamine = aclacinomycin T + dTDP + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.326", "l": "\"aklavinone 7-L-rhodosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35391", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA = (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176175", "l": "Stalling of DNA replication fork and RPA binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44520", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69892", "l": "Na(+)(out) + thymidine(out) => Na(+)(in) + thymidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210298", "l": "Interaction of DAP12 and KIR3DS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41978", "l": "a ganglioside GQ1balpha (d18:1(4E)) + CMP + H(+) => a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375131", "l": "Basigin binds CD98 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497863", "l": "The BH3 radical can decay to dihydrobiopterin (BH2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446364", "l": "Migfilin interacts with VASP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31679", "l": "O2 + prosolanapyrone II = H2O2 + prosolanapyrone III", "d": [], "t": []}, {"i": "EC:1.1.3.42", "l": "\"prosolanapyrone-II oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75115", "l": "all-trans-13,14-dihydroretinol + NAD(+) = all-trans-13,14-dihydroretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75046", "l": "L-cystine(out) + L-leucine(in) <=> L-cystine(in) + L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989764", "l": "Expression of CYP1A1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10964", "l": "ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.17", "l": "\"xylulokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49892", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2 = (5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114264", "l": "Translocation of activated BAX to the mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179413", "l": "Activated PKC-alpha  activate MMP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990738", "l": "pseudouridine 5'-phosphatase activity", "d": ["Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78900", "l": "a long-chain fatty acyl-CoA + acetyl-CoA => a long-chain 3-oxo-fatty acyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043015", "l": "gamma-tubulin binding", "d": ["Binding to the microtubule constituent protein gamma-tubulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34727", "l": "H2O + N-acyl-15-methylhexadecasphinganine = 15-methylhexadecasphinganine + a carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018452", "l": "5-exo-hydroxycamphor dehydrogenase activity", "d": ["Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76218", "l": "2'-deoxyguanosine(in) <=> 2'-deoxyguanosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57522", "l": "3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23111", "l": "D-arabinono-1,4-lactone + H2O <=> D-arabinonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38717", "l": "ADP + choline(in) + H(+) + phosphate => ATP + choline(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22623", "l": "H(+) + L-tryptophan + O2 <=> 3-indoleglycolaldehyde + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62785", "l": "2 fonsecin B + H(+) + NADPH + O2 => bifonsecin B + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13718", "l": "2-C-methyl-D-erythritol 4-phosphate + NADP(+) => 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47925", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate => (2S)-3-sulfolactaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74299", "l": "D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56745", "l": "2-oxoglutarate + L-arginyl-[protein] + O2 => (3R)-3-hydroxy-L-arginyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213239", "l": "Formation of MHC II alpha beta heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66513", "l": "1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73622", "l": "CTP(out) + GTP(in) <=> CTP(in) + GTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209097", "l": "ARM binds to APC and AXN in the 'destruction complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63890", "l": "CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine => hexadecanoyl-CoA + sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34852", "l": "(3S)-3-hydroxyadipyl-CoA + NAD(+) => 3-oxoadipyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351208", "l": "Spermidine  => N-acetylated spermidine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65076", "l": "dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672011", "l": "p-AMPK:AMP binds the ULK complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008311", "l": "double-stranded DNA 3'-5' DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16710", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55302", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853762", "l": "RET dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24920", "l": "L-homoserine => 2-aminobut-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015158", "l": "raffinose transmembrane transporter activity", "d": ["Enables the transfer of raffinose from one side of a membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48647", "l": "prostaglandin H2 <=> (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917693", "l": "ESCRT Disassembly (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54737", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60823", "l": "H2O + NADPH <=> adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213201", "l": "Formation of collagen fibres (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44097", "l": "decan-1-ol + hexadecanoyl-CoA => CoA + decanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20767", "l": "(S)-methylmalonyl-CoA + pyruvate <=> oxaloacetate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805620", "l": "KAT6A and PML bind TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27393", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = dichlorochromopyrrolate + H(+) + 2 H2O + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.215", "l": "\"arabinogalactan exo alpha-(1,3)-alpha-D-galactosyl-(1->3)-L-arabinofuranosidase (non-reducing end)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33612", "l": "H2O + methyl salicylate => H(+) + methanol + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19580", "l": "luteolin + UDP-alpha-D-glucose <=> H(+) + luteolin 7-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9844587", "l": "GAL3ST1 transfers sulfate to GalCer,LacCer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12292", "l": "ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9824999", "l": "GSK3B phosphorylates p-S73 MITF-M at residue S69 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390663", "l": "ADRA2A,B,C bind ADR,NAd (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.10", "l": "\"carboxypeptidase E\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247844", "l": "WNT ligands traffic to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19123", "l": "ADP + an S-substituted glutathione(out) + H(+) + phosphate => an S-substituted glutathione(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78141", "l": "a 1,3-diacylglycerol + a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451310", "l": "Activation of Edited Kainate receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785213", "l": "LIPC dimer binds heparin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60638", "l": "choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate => N-(dodecanoyl)-sphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51770", "l": "4-prenylphlormethylbutanophenone + diphosphate => 2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13954", "l": "a D-aminoacyl-tRNA + H2O => a D-alpha-amino acid + a tRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62904", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11879", "l": "NAD(+) + prostaglandin E2 <=> 15-oxoprostaglandin E2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29474", "l": "D-ribose 5-phosphate + H2O <=> D-ribose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:1990088", "l": "[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase", "d": ["Catalysis of the reaction: a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-coenzyme M + a [Co(I) methanol-specific corrinoid protein] + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103118", "l": "UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity", "d": ["Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + an (3R)-3-hydroxymyristoyl-[acp] = UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H+ + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27335", "l": "2,5-dihydroxypyridine + CO2 + H2O + NAD(+) => 6-hydroxynicotinate + 2 H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954056", "l": "E2F6 binds TFDP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78474", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62047", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O <=> (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47680", "l": "D-galactosamine 6-phosphate + H2O = D-tagatopyranose 1-phosphate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43299", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44026", "l": "(2E)-dodecenoyl-CoA + H2O => (3R)-3-hydroxydodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66426", "l": "ADP + H(+) + leukotriene B4(out) + phosphate => ATP + H2O + leukotriene B4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130194", "l": "ABL phosphorylates WAVEs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65370", "l": "a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52043", "l": "L-cystine <=> 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939129", "l": "miR-215 binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354087", "l": "Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017064", "l": "fatty acid amide hydrolase activity", "d": ["Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71104", "l": "L-methionine(in) + S-methylmercury-L-cysteine(out) => L-methionine(out) + S-methylmercury-L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43623", "l": "L-serine + NADP(+) <=> aminoacetaldehyde + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19983", "l": "H(+) + NADPH + S-formylglutathione => NADP(+) + S-(hydroxymethyl)glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20596", "l": "H2O + N-acetyl-D-glucosamine <=> acetate + D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420243", "l": "GHRH receptor binds GHRH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24438", "l": "dihydromethanophenazine => H2 + methanophenazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40098", "l": "26-oxohexacosanoate + H2O + NAD(+) <=> 2 H(+) + hexacosanedioate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69059", "l": "H(+) + N(omega)-methyl-L-arginine + NADH + O2 <=> H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73124", "l": "isorhamnetin + S-adenosyl-L-methionine => H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050184", "l": "phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: An oleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a linoleoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014587", "l": "Transcription of ROBO3.2 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30580", "l": "H2O + O-phospho-L-threonine => L-threonine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37334", "l": "H2O + L-methionyl-L-alanine <=> L-alanine + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939335", "l": "RNF181 polyubiquinates BCL10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26336", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O <=> 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28168", "l": "5-nitrosalicylate + NH4(+) => 5-nitroanthranilate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627350", "l": "SMAC (DIABLO) binds XIAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52772", "l": "7,8-dihydroneopterin 3'-triphosphate = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate", "d": [], "t": []}, {"i": "EC:4.1.2.60", "l": "\"dihydroneopterin triphosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16719", "l": "cholate + FADH2 => deoxycholate + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48393", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose => a neolactoside IV(3)-alpha-NeuNAc,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727349", "l": "XDH dehydrogenates xanthine to form urate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805399", "l": "TAF1 phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15513", "l": "ATP + keto-D-tagatose = ADP + H(+) + keto-D-tagatose 6-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.101", "l": "\"tagatose kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46043", "l": "2'-deoxycytidine + ATP <=> ADP + dCMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848818", "l": "PTK6 phosphorylates CBL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32883", "l": "(11R)-dihydroartemisinic aldehyde + NADP(+) = (+)-artemisinic aldehyde + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.92", "l": "\"artemisinic aldehyde Delta(11(13)) reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53007", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120295", "l": "histone serotonyltransferase activity", "d": ["Catalysis of the reaction: L-glutaminyl-[histone] + serotonin = 5-serotonyl-L-glutamyl-[histone] + NH4(+)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77812", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-valine + O2 => (2S)-3-methyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]butanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21994", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[histone] => acetyl-CoA + L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70275", "l": "H2O + raffinose = D-galactose + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047352", "l": "adenylylsulfate-ammonia adenylyltransferase activity", "d": ["Catalysis of the reaction: 5'-adenylyl sulfate + NH4 = adenosine 5'-phosphoramidate + 2 H+ + sulfate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50022", "l": "adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+) => decanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51311", "l": "H(+) + L-methionyl-[F-actin] + NADPH + O2 <=> H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75219", "l": "H2O + L-fucono-1,5-lactone = H(+) + L-fuconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57686", "l": "2 H(+) + 2 H2O + pyridinestrone carboxylate => 4-hydroxyestrone + NH4(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29096", "l": "5 H(+)(in) + NADH + ubiquinone-8 => 4 H(+)(out) + NAD(+) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429683", "l": "CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250930", "l": "B-WICH recruits histone acetyltransferases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419644", "l": "Transphosphorylation of pLIMK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866941", "l": "MID1IP1 binds THRSP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195730", "l": "Transport of processed viral proteins to the cell membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14803", "l": "(2R)-3-phospho-glyceroyl phosphate + ADP => (2R)-3-phosphoglycerate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8945709", "l": "miR-20 microRNAs bind PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49915", "l": "(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54092", "l": "3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 = 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67634", "l": "a plastoquinol + 4 H(+)(out) + 2 oxidized [2Fe-2S]-[ferredoxin] => a plastoquinone + 6 H(+)(in) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58048", "l": "2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA = 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53390", "l": "5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate] + H(+) + UDP => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810076", "l": "DDO oxidizes D-Asp to OA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196753", "l": "2xPPCS ligates PPanK with Cys (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32556", "l": "(2E)-geranyl diphosphate + H2O => (R)-alpha-terpineol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483219", "l": "PC is exchanged with PI by PITPNB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57000", "l": "acetyl-CoA + streptothricin F = CoA + H(+) + N(beta)-acetylstreptothricin F", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61342", "l": "CO2 + propanoyl-CoA => (S)-methylmalonyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604722", "l": "Activation of proMMP9 by proteases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24296", "l": "(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate", "d": [], "t": []}, {"i": "EC:3.5.2.3", "l": "\"dihydroorotase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64902", "l": "H(+) + phosphate + UDP => H2O + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23288", "l": "acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.10", "l": "\"acetaldehyde dehydrogenase (acetylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067640", "l": "IL6 binds IL6R-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68731", "l": "26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61859", "l": "dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2 <=> betaenone C + 3 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675417", "l": "PEBP1 binds activated RAF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48472", "l": "a ganglioside GT1a + H2O = a ganglioside GD1a + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033799", "l": "myricetin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061579", "l": "N-acyl homoserine lactone synthase activity", "d": ["Catalyzing the reaction: acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine -> [acyl-carrier- protein] + S-methyl-5'-thioadenosine + N-acyl-L-homoserine lactone."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52996", "l": "[eIF5A protein]-N-(4-aminobutylidene)-L-lysine + H(+) + NADH = [eIF5A protein]-deoxyhypusine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15625", "l": "Co-precorrin-6B + NAD(+) = Co-precorrin-6A + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.106", "l": "\"cobalt-precorrin-6A reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41970", "l": "a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+) => a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003834", "l": "beta-carotene 15,15'-dioxygenase activity", "d": ["Catalysis of the reaction: all-trans-beta-carotene + O2 = 2 all-trans-retinal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72419", "l": "(E)-4-coumarate + ATP + H(+) = (E)-4-coumaroyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18496", "l": "benzoyl-CoA + glycine <=> CoA + H(+) + N-benzoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831702", "l": "M dimer localizes to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19544", "l": "L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> H(+) + L-glutamyl 5-phosphate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18421", "l": "acetyl-CoA + chloramphenicol = chloramphenicol 3-acetate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.28", "l": "\"chloramphenicol O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388831", "l": "Phosphorylation of CD28 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64677", "l": "3-(methylsulfanyl)propanoyl-CoA + butan-1-ol => butyl 3-(methylsulfanyl)propanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.42", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48792", "l": "GDP-beta-L-fucose + Lc4Cer = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27832", "l": "beta-phellandrene + diphosphate => neryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53381", "l": "5,6-dihydrouridine(16) in tRNA + NAD(+) => H(+) + NADH + uridine(16) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56184", "l": "a globoside Gb4Cer + UDP-alpha-D-galactose = a globoside NOR1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53759", "l": "allodeoxycholoyl-CoA + cholate <=> allodeoxycholate + choloyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30012", "l": "ATP + beta-D-galactose(out) + H2O => ADP + beta-D-galactose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55315", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51524", "l": "(S)-corytuberine + S-adenosyl-L-methionine = magnoflorine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983307", "l": "IL15 binds IL15RA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53969", "l": "apo-[BtrI ACP] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19669", "l": "GTP + H2O = GDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28531", "l": "H2O + XMP => phosphate + xanthosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9734540", "l": "ACLY tetramer binds ETC-1002-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24755", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite <=> 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49550", "l": "H(+) + L-arginyl-[protein] + lactate => H2O + N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50984", "l": "prostaglandin E2(out) = prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010997", "l": "anaphase-promoting complex binding", "d": ["Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013009", "l": "RHOA binds effectors at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001162", "l": "RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding", "d": ["Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70935", "l": "L-lysine(in) = L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033743", "l": "peptide-methionine (R)-S-oxide reductase activity", "d": ["Catalysis of the reaction: peptide-L-methionine + H2O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209973", "l": "Tyrosine is diiodinated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58801", "l": "3',3'-cGAMP + H2O => 5'-pApG-3' + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51628", "l": "formate + H(+) + UTP = CO2 + dUTP + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29667", "l": "H2O(in) = H2O(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33598", "l": "(4R)-hydroxysphinganine + tetracosanoyl-CoA <=> CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33667", "l": "H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 = H2O + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801109", "l": "CHM binds RGGT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451418", "l": "Pellino ubiquitinates IRAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38419", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25273", "l": "ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.37", "l": "\"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672011", "l": "p-AMPK:AMP binds the ULK complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173111", "l": "Disassembly of viral capsid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55824", "l": "a 7(1),7(1)-dihydroxybacteriochlorophyllide d = a bacteriochlorophyllide f + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35859", "l": "1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.180", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654545", "l": "Ligand-independent phosphorylation of overexpressed FGFR1c (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54225", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine => 2-(prostaglandin E2)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25038", "l": "ATP + L-seryl-tRNA(Sec) => ADP + O-phospho-L-seryl-tRNA(Sec)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20572", "l": "H2O + L-arginine <=> L-ornithine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390929", "l": "HTR1 and 5A receptors can bind serotonin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295622", "l": "SPRY2 binds CBL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008822", "l": "PPM1D dephosphorylates RUNX2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204949", "l": "NRIF and TRAF6 may activate JNK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693609", "l": "ATM phosphorylates TP53 at S15 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029454", "l": "Autophosphorylation of PAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839358", "l": "Endocytosis of TGFBR3:ARRB complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48519", "l": "1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193641", "l": "IKK-beta is recruited (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68829", "l": "borneol + NAD(+) => camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68264", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002466", "l": "Formation of allysine by LOX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43786", "l": "H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine => adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14458", "l": "glyoxylate + H2O + pentanoyl-CoA => 3-propylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190256", "l": "FGFR1c binds to FGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140432", "l": "5'-hydroxyl dinucleotide hydrolase activity", "d": ["Catalysis of the hydrolysis of phosphodiester bonds in 5'OH-RNA according to the reaction 5'OH-RNA + H20 = 5'OH-NpN (dinucleotide) + 5'P-RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58201", "l": "2-oxoglutarate + 6-aminohexanoate => 6-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875523", "l": "MET binds TNS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45723", "l": "N-hexadecanoylsphing-4-enine(in) <=> N-hexadecanoylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10997", "l": "2-methylpropanal oxime + S-adenosyl-L-methionine => 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-507869", "l": "Aquaporins passively transport glycerol into cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22539", "l": "(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine <=> (S)-tetrahydropalmatine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69953", "l": "3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38805", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine => 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851908", "l": "Activated MET binds GAB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022378", "l": "ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25582", "l": "beta-L-fucose => alpha-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78678", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + silphinene <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + silphinene-15-oate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395340", "l": "Formation of hydroxyallysine by LOX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18345", "l": "a cis-3-alkyl-4-alkyloxetan-2-one = a cis-alkene + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.114", "l": "\"cis-3-alkyl-4-alkyloxetan-2-one decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18466", "l": "L-dopa + O2 => 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42108", "l": "(20S)-hydroxypregn-4-en-3-one + NAD(+) = H(+) + NADH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63588", "l": "prunetin + UDP-alpha-D-glucuronate = prunetin-4'-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247840", "l": "WLS binds WNT ligands in the Golgi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28517", "l": "(R)-carnitine + ATP + CoA <=> (R)-carnitinyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48134", "l": "(2E,6E)-farnesol + phosphate => (2E,6E)-farnesyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759157", "l": "NFE2L2-dependent SQSTM1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21537", "l": "(3S)-hydroxy-3-methylglutaryl-CoA => 3-methyl-(2E)-glutaconyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12543", "l": "ATP + L-alanine + tRNA(Ala) <=> AMP + diphosphate + L-alanyl-tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66963", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose <=> beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0046625", "l": "sphingolipid binding", "d": ["Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1168640", "l": "Ubiquitinated IkB is degraded (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759859", "l": "Expression of GATA4 in lateral plate mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21137", "l": "(R)-carnitine + acetyl-CoA => CoA + O-acetyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60838", "l": "a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate => a 5'-end diphospho-adenosine in mRNA + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856525", "l": "ANGPTL8 binds ANGPTL3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70022", "l": "O2 + reduced [NADPH--hemoprotein reductase] + typhasterol <=> 7-oxatyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76816", "l": "D-alanine + H2O + NAD(+) => H(+) + NADH + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205319", "l": "Interaction of APS and p-KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30993", "l": "24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77884", "l": "D-ribulose 1,5-bisphosphate + H2O => D-ribulose 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51496", "l": "a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13482", "l": "ATP + L-methionine + tRNA(Met) => AMP + diphosphate + L-methionyl-tRNA(Met)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39556", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18109", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.42", "l": "\"geranylgeranylglycerol-phosphate geranylgeranyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.38", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64434", "l": "H(+)(in) + L-alanyl-L-prolylglycine(in) => H(+)(out) + L-alanyl-L-prolylglycine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52882", "l": "16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16beta,17beta-estriol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50229", "l": "FADH2 + O2 + resorcinol => benzene-1,2,4-triol + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166015", "l": "Association of LBP with LPS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30948", "l": "(2E,6E)-farnesyl diphosphate + H2O => 10-epi-gamma-eudesmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71399", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin = 2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10654", "l": "a long-chain fatty acid + 2 H(+) + NADH => a long-chain fatty aldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16070", "l": "cytidine + H(+) + H2O => NH4(+) + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47039", "l": "uridine in 5S rRNA <=> pseudouridine in 5S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20554", "l": "(R)-methylmalonyl-CoA => (S)-methylmalonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617431", "l": "Retinoic acid activates HOXA1 chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58466", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP => a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59391", "l": "a fatty acid ester + H2O <=> a fatty acid + an aliphatic alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60002", "l": "formate + 2 H(+) + phosphate => hydroxymethylphosphonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014454", "l": "RHOG translocates to the ER membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13273", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol = 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.19", "l": "\"triglucosylalkylacylglycerol sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549533", "l": "Expression of PERIOD-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60341", "l": "N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12953", "l": "ATP + L-seryl-[Goodpasture antigen-binding protein] = ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9825782", "l": "p-S207 KARS1 dimer binds MITF-M:HINT1 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35041", "l": "spermidine(out) => spermidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203979", "l": "Coat Assembly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429992", "l": "PARN deadenylates mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9649733", "l": "mature p21 RAS binds GDP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178178", "l": "PP1 dephosphorylates TGFBR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23144", "l": "H2O + N-acetyl-alpha-D-glucosamine + NAD(+) = 2 H(+) + N-acetyl-D-glucosaminate + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.240", "l": "\"N-acetylhexosamine 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39058", "l": "22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912627", "l": "CBL ubiquitinates PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21569", "l": "beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41682", "l": "a 2-all-trans-polyprenylphenol + CO2 => a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70090", "l": "methanol + o-quinone methide <=> hydroxyclavatol methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10138", "l": "2-hydroxy-3-oxopropanoate + CO2 => 2 glyoxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.2.11", "l": "\"(3R)-3-[(carboxylmethyl)amino]fatty acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78765", "l": "D-glucose + N-deacetylipecoside aglycone => H2O + N-deacetylipecoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77342", "l": "(2S)-2-aminobutanoate + glyoxylate <=> 2-oxobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43725", "l": "(2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + juvenile hormone III carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985943", "l": "p-Y701-STAT1 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340226", "l": "CYGB dioxygenates NO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30056", "l": "L-allo-threonine + NADP(+) => (2S)-2-amino-3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60155", "l": "gamma-L-glutamyl-L-glutamyl-[protein] + H2O <=> L-glutamate + L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20395", "l": "(R)-4'-phosphopantetheine + acetyl-[citrate lyase ACP] => holo-[citrate lyase ACP] + S-acetylphosphopantotheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57465", "l": "(E)-caffeate + UDP-alpha-D-glucose => 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62100", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68170", "l": "2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] => N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008814", "l": "citrate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54488", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = 1-heptanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0016531", "l": "copper chaperone activity", "d": ["Directly binding to and delivering copper ions to a target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018515", "l": "pimeloyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + pimelyl-CoA = 2,3-didehydropimeloyl-CoA + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68215", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol <=> 1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76711", "l": "(15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58928", "l": "(3R,4R)-7,2',4'-trihydroxyisoflavanol = (6aR,11aR)-3,9-dihydroxypterocarpan + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0033971", "l": "hydroxyisourate hydrolase activity", "d": ["Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36501", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH => 2-dehydro-3-deoxy-L-rhamnonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54015", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64490", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA => acetyl-CoA + 5 H(+) + holo-[ACP] + 5 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15991", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH => (R)-mevalonate + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17692", "l": "3'-phosphoadenylyl sulfate + glycochenodeoxycholate <=> adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047489", "l": "pectate disaccharide-lyase activity", "d": ["Catalysis of the reaction: a pectate = a pectate + 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate. This reaction is the eliminative cleavage of 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211951", "l": "CYP1B1 4-hydroxylates EST17b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-481007", "l": "Exocytosis of platelet alpha granule contents (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18861", "l": "a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine = a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56387", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 <=> (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791016", "l": "SFTPB binds itself (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:1903425", "l": "fluoride transmembrane transporter activity", "d": ["Enables the transfer of fluoride from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69619", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5671993", "l": "CIT-3 binds DLG4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708866", "l": "pro-F2R binds vorapaxar (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033780", "l": "taurochenodeoxycholate 6alpha-hydroxylase activity", "d": ["Catalysis of the reaction: taurochenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase] +  = taurohyocholate H+ + H2O + oxidized [NADPH--hemoprotein reductase]. Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685602", "l": "NCR3LG1 binds NCR3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203977", "l": "SAR1 Activation And Membrane Binding (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.5.2", "l": "\"caffeine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667563", "l": "AVPR2 bind desmopressin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052589", "l": "malate dehydrogenase (menaquinone) activity", "d": ["Catalysis of the reaction: (S)-malate + a menaquinone = oxaloacetate + a menaquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682863", "l": "RNF168 binds DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19149", "l": "L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0015205", "l": "nucleobase transmembrane transporter activity", "d": ["Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444661", "l": "HCAR2 binds HCAR2 ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28489", "l": "Fe(2+)(in) <=> Fe(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655760", "l": "Defective SLC40A1 does not transport Fe3+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46904", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate) = a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65307", "l": "2-oxoglutarate + O2 + verruculide A <=> chrodrimanin T + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162186", "l": "COQ3 methylates DeMQ10H2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080049", "l": "L-gulono-1,4-lactone dehydrogenase activity", "d": ["Catalysis of the reaction: L-gulono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20023", "l": "amidinoproclavaminate + CO2 + succinate => 2-oxoglutarate + deoxyamidinoproclavaminate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.89", "l": "\"4'-methoxyisoflavone 2'-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36289", "l": "7-methylxanthine + formaldehyde + H2O + NADP(+) => H(+) + NADPH + O2 + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39329", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O => (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14344", "l": "2-oxoglutarate + glyoxylate + H(+) <=> 2-hydroxy-3-oxoadipate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112342", "l": "Inactivation of MAP2K1 by CDK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70573", "l": "argininosuccinate <=> fumarate + arginine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65633", "l": "a sphingoid base + tetracosanoyl-CoA => an N-tetracosanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692867", "l": "HRH3 binds pitosilant (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73134", "l": "8-hydroxy-7-methoxyflavone + S-adenosyl-L-methionine <=> 7,8-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10335", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856502", "l": "mito-STARD7 transports Q10 to outer mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49759", "l": "H(+) + O2 + protoviolaceinate <=> CO2 + H2O + proviolacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39794", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20030", "l": "10-deoxysarpagine + NADP(+) => H(+) + NADPH + vellosimine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.4", "l": "\"glutamate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844620", "l": "dsDNA:AIM2 clusters bind ASC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31206", "l": "acetyl-CoA + hexanoyl-CoA <=> 3-oxooctanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709879", "l": "BIL scavenges O2.- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78368", "l": "H2O + N(tau)-methylhistamine + O2 => 1-methylimidazole-4-acetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74811", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65123", "l": "H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione <=> L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13148", "l": "4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate <=> alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69558", "l": "D-glucose(in) + H(+)(in) => D-glucose(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052679", "l": "terpentetriene synthase activity", "d": ["Catalysis of the reaction: terpentedienyl diphosphate = diphosphate + terpentetriene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461993", "l": "pro-HD5 is cleaved by trypsin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106290", "l": "trans-cinnamate-CoA ligase activity", "d": ["Catalysis of the reaction: (E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate."], "t": []}, {"i": "RHEA:64788", "l": "(E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45541", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863727", "l": "STON2 is neddylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25725", "l": "2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769401", "l": "DKK and KRM bind LRP5/6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941618", "l": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63054", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61971", "l": "a 1-O-(9Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-O-(1Z,9Z-octadecadienyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70596", "l": "GOT2 dimer deaminates L-Asp (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52736", "l": "(Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate = (Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938887", "l": "PML binds RUNX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52931", "l": "3',3'-c-di-GMP + 2 H2O <=> 2 GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250264", "l": "TXNIP binds reduced thioredoxin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16939", "l": "1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-alkyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088130", "l": "PLK1 binds FOXM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44884", "l": "a cardiolipin + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61801", "l": "ATP + holo-[peptidyl-carrier protein] + L-alanine => AMP + diphosphate + L-alanyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71250", "l": "beta-alanine(out) + chloride(out) + 2 Na(+)(out) <=> beta-alanine(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052654", "l": "L-leucine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10814", "l": "2 H(+) + N-succinyl-L-glutamate + NADH => H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351207", "l": "Spermine  => N-acetylated spermine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21082", "l": "diphosphate + phosphate + S-adenosyl-L-methionine => ATP + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41070", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68615", "l": "H(+) + NADPH + prostaglandin E1 <=> NADP(+) + prostaglandin F1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944262", "l": "Association of procollagen type X (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9761344", "l": "USP18 binds IKBKG within IKK complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56780", "l": "(+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607744", "l": "MALT1 binds BCL10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730840", "l": "Activation of RAC1 by VAV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25312", "l": "glycolate + O2 => glyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78903", "l": "a medium-chain fatty acyl-CoA + acetyl-CoA = a medium-chain 3-oxoacyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112124", "l": "Oxidative demethylation of 3-meC damaged DNA By ALKBH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53591", "l": "NAD(+) + resolvin D2 <=> 16-oxoresolvin D2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0015189", "l": "L-lysine transmembrane transporter activity", "d": ["Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57018", "l": "3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24150", "l": "(2R)-3-phosphoglycerate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12958", "l": "an acetyl ester + H2O => acetate + an aliphatic alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034937", "l": "perchlorate reductase activity", "d": ["Catalysis of the reaction: perchlorate + 2 H+ + 2 e- = chlorate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19709", "l": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.51", "l": "\"1-acylglycerol-3-phosphate O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50700", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = calcitriol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75174", "l": "GTP + NAD(+) <=> GDP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68371", "l": "3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose <=> 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730858", "l": "Autophosphorylation of BTK/ITK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33845", "l": "sphinganine + tetracosanoate => H2O + N-tetracosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714580", "l": "SLC6A3 binds DRIs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51450", "l": "alpha-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => chenodeoxycholate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46587", "l": "1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] <=> 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373746", "l": "SEMA4D interacts with CD45 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10967", "l": "ATP + D-xylulose <=> ADP + D-xylulose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9769235", "l": "MAGED1 binds NPAS4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20659", "l": "4-chlorophenylacetate + NH4(+) => 4-chlorophenylacetonitrile + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191830", "l": "snRNP nuclear import and release (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33910", "l": "4-(methylamino)butanoate + H2O + O2 <=> 4-aminobutanoate + formaldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41939", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45739", "l": "(3E)-hexenoyl-CoA <=> (2E)-hexenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74094", "l": "ATP + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) <=> ADP + H(+) + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25332", "l": "3-dehydrocarnitine + H(+) + NADH => (R)-carnitine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75857", "l": "9-cis-4-oxoretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 9-cis-4-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0004564", "l": "beta-fructofuranosidase activity", "d": ["Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712190", "l": "cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448627", "l": "Interleukin-35 translocates from the ER lumen to the extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191737", "l": "Docking of connexons into junctional, double-membrane spanning channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31989", "l": "baruol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004895", "l": "cell adhesion receptor activity", "d": ["The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45883", "l": "3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53085", "l": "[(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34457", "l": "9-cis-beta-carotene => all-trans-beta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205234", "l": "Indirect recruitment of GAB2 to p-KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29200", "l": "(S)-dihydroorotate + menaquinone-8 => menaquinol-8 + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17127", "l": "2-oxoglutarate + N-(2-aminobutanoyl)glycine => H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62257", "l": "Cd(2+)(out) + 2 hydrogencarbonate(out) => Cd(2+)(in) + 2 hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66398", "l": "ADP + cholate(out) + glutathione(out) + H(+) + phosphate => ATP + cholate(in) + glutathione(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632677", "l": "PTCH is internalized (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120299", "l": "peptide histaminyltransferase activity", "d": ["Catalysis of the reaction: histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein]."], "t": []}, {"i": "RHEA:66564", "l": "histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839091", "l": "Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73985", "l": "(-)-beta-barbatene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19830", "l": "a primary alcohol + O2 => an aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52053", "l": "9-hexadecanoyloxy-octadecanoate + H2O => 9-hydroxy-octadecanoate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810843", "l": "Envoplakin binds periplakin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32087", "l": "[4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphoenolpyruvate = [4)-beta-D-GlcA-(1->4)-2-O-Ac-beta-D-GlcA-(1->4)-beta-D-Glc-(1->4)-[3-O-(CH3CH(OH)CH2C(O))-(R)-4,6-CH3(COO(-))C-beta-D-Gal-(1->3)-(S)-4,6-CH3(COO(-))C-beta-D-Glc-(1->4)-beta-D-Glc-(1->4)-beta-D-Glc-(1->6)]-2-O-Ac-alpha-DGlc-(1->](n) + n phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.98", "l": "\"Rhizobium leguminosarum exopolysaccharide glucosyl ketal-pyruvate-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039630", "l": "RNA translocase activity", "d": ["Generating a movement along a single- or double-stranded RNA molecule, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102356", "l": "isoitalicene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = diphosphoric acid + (+)-isoitalicene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76695", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062182", "l": "all-trans retinoic acid 4-hydrolase activity", "d": ["Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}, {"i": "RHEA:51492", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54778", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+) => 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49212", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,25-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664888", "l": "ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047945", "l": "L-glutamine:pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16477", "l": "NAD(+) + prostaglandin E1 = 15-oxoprostaglandin E1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5669240", "l": "FLNA binds PAK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177922", "l": "EGFR dimerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77234", "l": "cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate) + H2O <=> (S)-2-hydroxypropylphosphonate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140951", "l": "histone H3K27 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl27-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl27-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66211", "l": "(8R)-8-hydroxynonanoyl-CoA + O2 <=> (2E,8R)-8-hydroxynonenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20358", "l": "3-phenylpropanoate + H(+) + NADH + O2 => 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59647", "l": "D-xylobiono-1,5-lactone + H2O <=> D-xylobionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43793", "l": "adenosine(645) in 25S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684273", "l": "3CLp cleaves pp1a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48052", "l": "n 3'-phosphoadenylyl sulfate + dermatan = n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.35", "l": "\"dermatan 4-sulfotransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65029", "l": "(+)-pinoresinol + H2O + 2 oxidized [azurin] => (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54328", "l": "2 H(+) + hexadecanoyl-[ACP] + 2 NADPH = hexadecan-1-ol + holo-[ACP] + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33498", "l": "all-trans-heptaprenyl diphosphate + sn-glycerol 1-phosphate <=> 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46230", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein] => apo-[peptidyl-carrier protein] + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56541", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoyl-sn-glycerol => 1,2-dihexanoyl-3-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10283", "l": "1,7-dimethylxanthine + S-adenosyl-L-methionine <=> caffeine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56985", "l": "(2E,6E)-farnesyl diphosphate + H2O => (6E)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71255", "l": "3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700171", "l": "Active ALK phosphorylates PLCG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62195", "l": "O2 + peregrinol + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46312", "l": "3-oxochol-4-en-22-oyl-CoA + acetyl-CoA = 3,22-dioxochol-4-en-24-oyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672980", "l": "Dissociation of RAS:RAF complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58049", "l": "2-O-sulfo-alpha,alpha-trehalose + octadecanoyl-CoA => 2-O-sulfo-2'-O-octadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42193", "l": "(9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16051", "l": "adenosylcob(III)alamin + GMP + H(+) => adenosylcob(III)inamide-GDP + alpha-ribazole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52450", "l": "16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31421", "l": "(-)-beta-curcumene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759332", "l": "AcK-NFE2L2 binds the TXNRD1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43355", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67486", "l": "a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77406", "l": "2-methylpropanal + hydrogen cyanide <=> (2S)-2-hydroxy-3-methylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74067", "l": "ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187382", "l": "Degradation of ubiquitinated SMAD3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51330", "l": "10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635845", "l": "GLI proteins bind CDC73 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41581", "l": "5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate => 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381109", "l": "IRE1 binds IRE1 forming dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52265", "l": "3-(aminomethyl)indole + 2 S-adenosyl-L-methionine => gramine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678843", "l": "ISGylation of protein translation regulator 4EHP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40814", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25230", "l": "L-arabinitol + NADP(+) => H(+) + L-arabinose + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28914", "l": "H(+)(out) + L-lysine(out) <=> H(+)(in) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168947", "l": "Ligand binds to TLR10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23568", "l": "(2E)-decenoyl-[ACP] = (3Z)-decenoyl-[ACP]", "d": [], "t": []}, {"i": "EC:5.3.3.14", "l": "\"trans-2-decenoyl-[acyl-carrier-protein] isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14912", "l": "L-gulonate + NADP(+) <=> aldehydo-D-glucuronate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42570", "l": "3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) => 2,3-dihydroxy-p-cumate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74579", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] = N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13322", "l": "(R)-3,3-dimethylmalate + NAD(+) => 3-methyl-2-oxobutanoate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31729", "l": "(S)-styrene oxide + FAD + H(+) + H2O => FADH2 + O2 + styrene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30372", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O => (-)-geosmin + acetone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11990", "l": "1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine => 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69514", "l": "H(+) + H2O2 + N-acetyl-D-galactosaminate => H2O + N-acetyl-D-galactosamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47806", "l": "epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68960", "l": "DNA polymerase epsilon binds at the origin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46968", "l": "A + dihydroisopentenyldehydrorhodopin = AH2 + isopentenyldehydrorhodopin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68069", "l": "a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] => a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014449", "l": "RHOG binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13446", "l": "(R)-pantetheine + H2O => (R)-pantothenate + cysteamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48109", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015661", "l": "L-lysine efflux transmembrane transporter activity", "d": ["Enables the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2995334", "l": "COX15 transforms heme O to heme A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1878002", "l": "XYLTs transfer Xyl to core protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36388", "l": "carbamoyl adenylate + kanamycin A => 6''-O-carbamoylkanamycin A + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60261", "l": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14950", "l": "A + H2O + quinoline-4-carboxylate => 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21920", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400204", "l": "PPARA binds RXRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27802", "l": "(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = all-trans-decaprenyl diphosphate + 7 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.91", "l": "\"all-trans-decaprenyl-diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043914", "l": "NADPH:sulfur oxidoreductase activity", "d": ["Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+."], "t": []}, {"i": "EC:1.8.1.18", "l": "\"NAD(P)H sulfur oxidoreductase (CoA-dependent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9861631", "l": "ME1 tetramerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134800", "l": "STING dimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71331", "l": "chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) = chloride(in) + L-phenylalanine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433454", "l": "Phosphorylation of GAB2 by SFKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212222", "l": "PRC2 recruits DNA methyltransferases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26050", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71352", "l": "androsterone 3alpha-sulfate(out) + 2 Na(+)(out) => androsterone 3alpha-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134953", "l": "DHX36 or DHX9 binds MyD88 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1461971", "l": "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33113", "l": "beta-copaene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53917", "l": "an acyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-acyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9703895", "l": "CASR binds CASR agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63997", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010211", "l": "IAA-Leu conjugate hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetyl-leucine + H2O = indole-3-acetate + L-leucine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668520", "l": "26Sproteasome degrades K48polyUb-NIK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56876", "l": "(R)-N-acetyl-1-phenylethylamine + H2O = (R)-1-phenylethylamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68145", "l": "ethyl 3-oxobutanoate + H(+) + NADPH => ethyl (R)-3-hydroxybutanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050275", "l": "scopoletin glucosyltransferase activity", "d": ["Catalysis of the reaction: scopoletin + UDP-D-glucose = H+ + scopolin + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71353", "l": "androsterone 3alpha-sulfate(in) + 2 Na(+)(in) => androsterone 3alpha-sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71181", "l": "L-histidine(in) + L-tryptophan(out) => L-histidine(out) + L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40188", "l": "(2E)-octenoyl-CoA + H2O => (3R)-hydroxyoctanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52841", "l": "UDP-alpha-D-glucose + vanillate => 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10489", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP => (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1449687", "l": "Corticosteroids bind to CBG in blood (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102878", "l": "(+)-alpha-barbatene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-alpha-barbatene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28879", "l": "H(+)(in) + L-tryptophan(in) = H(+)(out) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034432", "l": "bis(5'-adenosyl)-pentaphosphatase activity", "d": ["Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48972", "l": "ATP + H2O + phosphite(out) = ADP + H(+) + phosphate + phosphite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55604", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base = a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44569", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) => 2-all-trans-hexaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21051", "l": "ATP + isopropylamine + L-glutamate <=> ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682377", "l": "LC3 de-lipidation by ATG4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48213", "l": "a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31172", "l": "(3S)-hydroxytetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19317", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.18", "l": "\"5-(carboxyamino)imidazole ribonucleotide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621179", "l": "Cinaciguat binds sGC:NO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65673", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657665", "l": "ALKBH2 binds alkylated dsDNA containing 3-meC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.64", "l": "\"testosterone 17beta-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47330", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) => 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70347", "l": "bromide + L-tyrosine + NADP(+) = 3-bromo-L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296309", "l": "HCAR3 binds HCAR3 ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844716", "l": "MPHOSPH8 of the HUSH complex bound to retroelement chromatin binds ZCCHC8 of the NEXT complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17523", "l": "ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate => ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25447", "l": "(2E,6E)-farnesyl diphosphate <=> (1E,4E)-germacrene B + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17103", "l": "(R)-carnitine + a fatty acid + H(+) => H2O + O-acyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939201", "l": "ESR dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176517", "l": "SULTs transfer (SO4)2- group to PREG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046422", "l": "violaxanthin de-epoxidase activity", "d": ["Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; and antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046899", "l": "nucleoside triphosphate adenylate kinase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61760", "l": "rebaudioside B + UDP-alpha-D-glucose = rebaudioside A + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45923", "l": "16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37008", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(10Z,13Z,16Z,19Z)-docosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70256", "l": "1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol => cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5655483", "l": "USP1 autocleavage (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102693", "l": "UDP-glucose:kinetin 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + kinetin = H+ + kinetin-7-N-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26319", "l": "3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate => 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23313", "l": "2 sucrose => 1(F)-beta-D-fructosylsucrose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061653", "l": "ISG15 conjugating enzyme activity", "d": ["Isoenergetic transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y = Y-ISG15 + X, where both the X-ISG15 and Y-ISG15 linkages are thioester bonds between the C-terminal amino acid of ISG15 and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68603", "l": "ORC5 binds ORC2:ORC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-593685", "l": "Netrin-4 binds DCC/UNC5A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32080", "l": "(13E)-labda-7,13-dien-15-yl diphosphate + H2O => (13E)-labda-7,13-dien-15-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690023", "l": "NUBPL binds 4Fe-4S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101014", "l": "[isocitrate dehydrogenase (NADP+)] phosphatase activity", "d": ["Catalysis of the reaction: [isocitrate dehydrogenase] phosphate + H2O = [isocitrate dehydrogenase] + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62689", "l": "4 norrubrofusarin + O2 => 2 H2O + 2 ustilaginoidin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601926", "l": "RNA polymerase II polymerizes primary piRNA transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018112", "l": "proline racemase activity", "d": ["Catalysis of the reaction: L-proline = D-proline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12599", "l": "CoA + H(+) + N-acetylphosphinothricin => acetyl-CoA + phosphinothricin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031808", "l": "H2 histamine receptor binding", "d": ["Binding to a H2 histamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48422", "l": "a ganglioside GM1 (d18:1(4E)) + CMP + H(+) => a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59044", "l": "dammarenediol-II + UDP-alpha-D-glucose = (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034891", "l": "endosulfan diol dehydrogenase activity", "d": ["Catalysis of the reaction: endosulfan diol = endosulfan hydroxyether + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374667", "l": "DCC interaction with SIAH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33663", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70605", "l": "4-ethylphenol + NAD(+) => 4-hydroxystyrene + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42746", "l": "H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030629", "l": "U6 snRNA 3'-end binding", "d": ["Binding to a U6 small nuclear RNA (U6 snRNA) at the 3' end."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25198", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32594", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O <=> (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850997", "l": "TRIM27 binds PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73746", "l": "2 H(+)(out) + serotonin(in) <=> 2 H(+)(in) + serotonin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48355", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11268", "l": "D-cysteine + H2O = H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:4.4.1.15", "l": "\"D-cysteine desulfhydrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33528", "l": "acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol => CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40832", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688797", "l": "ATXN3 family cleave Ub chains (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39892", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine => dTDP + H(+) + vancomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33361", "l": "1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55515", "l": "cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27627", "l": "D-erythrose 4-phosphate + D-xylulose 5-phosphate => beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35292", "l": "11-methyldodecanoyl-CoA + H(+) + malonyl-CoA => 3-oxoisopentadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.63", "l": "\"kynurenine--glyoxylate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70649", "l": "D-serine(in) + H(+)(in) => D-serine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41019", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol = 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63009", "l": "(6Z)-octadecenamide + H2O => (6Z)-octadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793666", "l": "MDM2 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080070", "l": "8-methylthiooctyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 8-methylthiooctyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 8-methylthiooctyl-glucosinolate + adenosine 3',5'-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52831", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 <=> (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177920", "l": "Binding of GRB2 to GAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102654", "l": "1-18:1-2-16:0-phosphatidylglycerol trans-3 desaturase activity", "d": ["Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor = 1-18:1-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-434650", "l": "MATEs mediate extrusion of xenobiotics (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163625", "l": "Glucagon binds to Glucagon receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51216", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one = adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43633", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) => an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21237", "l": "anthranilate + 2 H(+) + NADPH + O2 => 2,3-dihydroxybenzoate + NADP(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35575", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] = (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67736", "l": "N-acetyl-alpha-neuraminate = aceneuramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17646", "l": "H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] => N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70365", "l": "1-carboxybiuret + H(+) => cyanurate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190256", "l": "FGFR1c binds to FGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43827", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803719", "l": "TP53 binds ZNF385A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022399", "l": "ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18572", "l": "an aromatic aldehyde + H2O + O2 <=> an aromatic carboxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45319", "l": "H(+) + NADPH + prostaglandin D2 <=> 11beta-prostaglandin F2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37265", "l": "ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate => ATP + H2O + L-alanyl-L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672817", "l": "Active MTORC1 binds the ULK1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10993", "l": "glycolate + NADP(+) => glyoxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093327", "l": "EPHA binds TIAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0005506", "l": "iron ion binding", "d": ["Binding to an iron (Fe) ion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54132", "l": "a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate = a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112510", "l": "IL6ST is tyrosine phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9706837", "l": "AR binds AR antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419428", "l": "S1PR2-5 bind S1P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38637", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60245", "l": "2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] => 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75059", "l": "chloride(out) + 2 hydrogencarbonate(in) + K(+)(in) = chloride(in) + 2 hydrogencarbonate(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42767", "l": "formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> CO2 + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20826", "l": "ADP + AMP + H(+) => adenosine + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42970", "l": "2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(56) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21267", "l": "A + glycolate <=> AH2 + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665727", "l": "FMNL2 binds CDC42:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016993", "l": "precorrin-8X methylmutase activity", "d": ["Catalysis of the reaction: precorrin-8X = hydrogenobyrinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047940", "l": "glucuronokinase activity", "d": ["Catalysis of the reaction: D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + 2 H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23241", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74039", "l": "D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66330", "l": "taurine(in) => taurine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66476", "l": "gypsogenate + UDP-alpha-D-glucose = gypsogenate 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24732", "l": "aniline + CO2 => anthranilate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38680", "l": "ATP + H2O + sphinganine(in) => ADP + H(+) + phosphate + sphinganine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11181", "l": "ATP + L-asparagine + tRNA(Asn) => AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52985", "l": "7-oxoheptanoyl-[ACP] + H2O + oxidized [flavodoxin] => 6-carboxyhexanoyl-[ACP] + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.71", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32754", "l": "choline(out) <=> choline(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74133", "l": "H(+) + malvidin 3-O-beta-D-galactoside + UDP => malvidin + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034916", "l": "2-methylhexanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-methylhexanoyl-CoA = 2-methylhex-2-enoyl-CoA + 2 H+ + e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099581", "l": "ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential", "d": ["Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36795", "l": "a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24435", "l": "H2O + oxaloacetate <=> acetate + H(+) + oxalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36304", "l": "a fatty acyl-CoA + 2 H(+) + 2 NADPH => a long-chain primary fatty alcohol + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65776", "l": "chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59692", "l": "D-cellotriono-1,5-lactone + H2O = D-cellotrionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40251", "l": "4-O-methylrhodomycin D + H2O = 10-carboxy-13-deoxydaunorubicin + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77782", "l": "2-oxoglutarate + 6-sulfo-D-quinovose + O2 <=> 6-dehydro-D-glucose + CO2 + H(+) + succinate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15565", "l": "an N-acyl-L-amino acid + H2O = a carboxylate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.285", "l": "\"3''-deamino-3''-oxonicotianamine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28602", "l": "L-isoleucine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (1E,2S)-2-methylbutanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.39", "l": "\"isoleucine N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72686", "l": "cholate(out) <=> cholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72925", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III => O2 + proatranorin II + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21583", "l": "(2S)-2-acetolactate + H(+) <=> (R)-acetoin + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627089", "l": "CASP9 is phosphorylated at T412 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9824979", "l": "XPO1 binds p-S69,73 MITF-M (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71453", "l": "bradykinin(1-7) + L-Phe-L-Arg => bradykinin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68250", "l": "L-tyrosine(out) + Na(+)(out) => L-tyrosine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67678", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37437", "l": "a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32861", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374899", "l": "Release of noradrenaline  at the synapse (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647660", "l": "GSDME (1-270) binds PIPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21538", "l": "3-methyl-(2E)-glutaconyl-CoA + H2O => (3S)-hydroxy-3-methylglutaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102474", "l": "eriodictyol dibenzoylmethane tautomer 6C-glucosyltransferase activity", "d": ["Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose = 6C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30626", "l": "A + all-trans-neurosporene <=> AH2 + all-trans-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76247", "l": "ATP + ergothioneine(out) + H2O = ADP + ergothioneine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174439", "l": "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847977", "l": "FRK phosphorylates PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66034", "l": "alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35998", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864698", "l": "KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24140", "l": "guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.185", "l": "\"23S rRNA (guanosine(2251)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.34", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112727", "l": "Serine phosphorylation of STATs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507871", "l": "Aquaporins passively transport glycerol out of cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30901", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + H(+) + UDP => bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71419", "l": "3,3',5-triiodo-L-thyronine(out) + L-tyrosine(in) = 3,3',5-triiodo-L-thyronine(in) + L-tyrosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14350", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose => an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877620", "l": "ECE2 cleaves EDN1(53-90) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66530", "l": "diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => ATP + O-(5'-adenylyl)-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46380", "l": "7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33125", "l": "(R)-tetraprenyl-beta-curcumene + diphosphate => all-trans-heptaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454239", "l": "Phosphorylation of SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37130", "l": "2-oxoglutarate + dioxidophosphate + H2O2 <=> CO2 + H(+) + phosphonate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74153", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin] => acetyl-CoA + L-lysyl-[beta-tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140315", "l": "iron ion sequestering activity", "d": ["Binding to an iron ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57443", "l": "2-methylanisole + O2 + reduced [NADH--hemoprotein reductase] <=> 2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15657", "l": "1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO2 + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.68", "l": "\"1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23940", "l": "D-gluconate + NAD(+) = 5-dehydro-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27384", "l": "(2R)-2,3-bisphosphoglycerate + H2O <=> (2R)-2-phosphoglycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161668", "l": "PGA2 is dehydrated to 15d-PGA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034479", "l": "phosphatidylglycerol phospholipase C activity", "d": ["Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33970", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O <=> 3-maleylpyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39802", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+) <=> 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56739", "l": "H2O + O2 + retinal <=> H(+) + H2O2 + retinoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0047598", "l": "7-dehydrocholesterol reductase activity", "d": ["Catalysis of the reaction: cholesterol + NADP+ = 7-dehydrocholesterol + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52110", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36214", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57585", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66171", "l": "[protein]-with a C-terminal TM segment(out) + ATP + H2O <=> [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47002", "l": "NAD(+) + 2 NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NADH + 2 NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16956", "l": "2-oxoglutarate + N(2)-succinyl-L-ornithine <=> L-glutamate + N-succinyl-L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682388", "l": "Autophagosome maturation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20590", "l": "glutaryl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36429", "l": "diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine => 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757256", "l": "MCM3 binds MCM5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.196", "l": "\"L-ornithine N(5)-monooxygenase [NAD(P)H]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30449", "l": "formaldehyde + H2O + NAD(+) + xanthine => 3-methylxanthine + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69771", "l": "a short-chain fatty aldehyde + H2O + NAD(+) = a short-chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032775", "l": "YAP1 binds TEAD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76009", "l": "(3R)-hydroxybutanoate tetramer + (R)-3-hydroxybutanoate + H(+) => (3R)-hydroxybutanoate pentamer + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23584", "l": "7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.12", "l": "\"dihydrofolate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72393", "l": "2 hydrogencarbonate(in) + oxalate(out) => 2 hydrogencarbonate(out) + oxalate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052868", "l": "protein-lysine lysyltransferase activity", "d": ["Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20226", "l": "(E)-caffeate + S-adenosyl-L-methionine => (E)-ferulate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27367", "l": "bromomethane + S-adenosyl-L-homocysteine => bromide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858252", "l": "HDLBP binds HDL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102452", "l": "bisdemethoxycurcumin synthase activity", "d": ["Catalysis of the reaction: 2 4-coumaryl-CoA + malonyl-CoA + H2O + H+ = 3 coenzyme A + bisdemethoxycurcumin + 2 carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63462", "l": "(2E,6E,10E)-geranylgeranyl phosphate + GDP + H(+) => (2E,6E,10E)-geranylgeraniol + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467794", "l": "Resolution of sister chromatids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734597", "l": "MEF2C binds the SMYD1 (BOP) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34062", "l": "agroclavine + NADP(+) <=> didehydroagroclavine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54750", "l": "AMP + diphosphate + L-firefly luciferyl-CoA => ATP + CoA + firefly L-luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170120", "l": "Translocation of Cdc25B to the cytoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871260", "l": "YAP1 binds TEAD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730843", "l": "Phosphorylation of LAT by p-SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017095", "l": "heparan sulfate 6-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate."], "t": []}, {"i": "REACT:R-HSA-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050243", "l": "pyruvate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: CoA + NADP+ + pyruvate = acetyl-CoA + CO2 + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51134", "l": "2-deoxy-D-ribose 5-phosphate + a purine nucleobase => a purine 2'-deoxyribonucleoside 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12933", "l": "L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}, {"i": "EC:4.1.2.17", "l": "\"L-fuculose-phosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79133", "l": "H2O + L-alanocholate => cholate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0003909", "l": "DNA ligase activity", "d": ["Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51010", "l": "2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+) => 2 Fe(III)-[cytochrome cL] + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14328", "l": "7,8-dihydroxycoumarin + UDP-alpha-D-glucose <=> daphnin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0008379", "l": "thioredoxin peroxidase activity", "d": ["Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428625", "l": "Vesicular inhibitory amino acid transport (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047071", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687675", "l": "LIG3 ligates remaining SSBs in MMEJ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004877", "l": "complement component C3b receptor activity", "d": ["Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70835", "l": "L-arginine(in) + L-glutamine(out) + Na(+)(out) = L-arginine(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29858", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine <=> D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16814", "l": "H2O + L-kynurenine => anthranilate + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691131", "l": "CANDI binds CUL1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18357", "l": "NADP(+) + tropine = H(+) + NADPH + tropinone", "d": [], "t": []}, {"i": "EC:1.1.1.206", "l": "\"tropinone reductase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74148", "l": "(S)-2-benzoylsuccinyl-CoA + CoA => benzoyl-CoA + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72153", "l": "estrone 3-sulfate(in) + glutarate(out) => estrone 3-sulfate(out) + glutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203977", "l": "SAR1 Activation And Membrane Binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420980", "l": "Activation of Ca permeable AMPA receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13834", "l": "L-arginine + pyruvate => 5-guanidino-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35192", "l": "noranthrone + O2 => H2O + norsolorinic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210298", "l": "Interaction of DAP12 and KIR3DS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67169", "l": "2-oxoglutarate + 3-hydroxy-L-phenylalanine => 3-(3-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24306", "l": "CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] => glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17559", "l": "CoA + N-malonylanthranilate => anthranilate + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23404", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.41", "l": "\"phosphoglycerol geranylgeranyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75862", "l": "Fall Back to Closed Pre-initiation Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50012", "l": "H(+) + NADPH + O2 + tert-butanol = 2-methylpropane-1,2-diol + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.229", "l": "\"tert-butanol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15394", "l": "(2S,6S)-2,6-diaminoheptanedioate => meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69603", "l": "UTP = 3',5'-cyclic UMP + diphosphate", "d": [], "t": []}, {"i": "EC:4.6.1.26", "l": "\"uridylate cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35954", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate <=> diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26465", "l": "6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine <=> 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964492", "l": "DREAM complex binds the RBL1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76953", "l": "2-methylpropanal + H(+) + methylamine + NADH => H2O + N-methyl-2-methylpropanamine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27676", "l": "ADP + dATP => ATP + dADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43872", "l": "3-oxochol-4-en-22-oate + ATP + CoA = 3-oxochol-4-en-22-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954056", "l": "E2F6 binds TFDP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75750", "l": "10-oxooctadecanoate + H(+) + NADH <=> 10-hydroxyoctadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839067", "l": "Phosphorylation of BCR moiety of BCR-FGFR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70926", "l": "(R)-noradrenaline(out) + chloride(out) + Na(+)(out) <=> (R)-noradrenaline(in) + chloride(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52419", "l": "3-dehydro-4-O-phospho-D-erythronate + H(+) <=> CO2 + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17480", "l": "precorrin-6B + 2 S-adenosyl-L-methionine <=> CO2 + 3 H(+) + precorrin-8X + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32154", "l": "9alpha-copalyl diphosphate <=> (12E)-9alpha-labda-8(17),12,14-triene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51941", "l": "(1E,2S)-2-methylbutanal oxime => (1Z,2S)-2-methylbutanal oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69052", "l": "H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2 = 3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.250", "l": "\"nitrosourea synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047755", "l": "isocitrate epimerase activity", "d": ["Catalysis of the reaction: D-threo-isocitrate = D-erythro-isocitrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60167", "l": "a guanosine in RNA + S-adenosyl-L-methionine <=> an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20841", "l": "H(+) + L-histidine => CO2 + histamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17115", "l": "H(+) + L-serine + phosphoethanolamine => H2O + L-serine-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31883", "l": "(S)-2,3-epoxysqualene = delta-amyrin", "d": [], "t": []}, {"i": "EC:5.4.99.55", "l": "\"delta-amyrin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641206", "l": "RSPOs bind LGRs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418172", "l": "F2R binds ARRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12518", "l": "(+)-(R)-germacrene A + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22994", "l": "acetyl-CoA + CO2 + NADH => 3-oxopropanoate + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66789", "l": "N-methyl-L-dopa + O2 => (3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66855", "l": "(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0047577", "l": "4-hydroxybutyrate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-hydroxybutanoate + NAD+ = H+ + NADH + succinate semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32422", "l": "(1S,2R,4R)-neoisodihydrocarveol + NAD(+) <=> (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-171122", "l": "LDL + LDLR => LDL:LDLR complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38081", "l": "1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38389", "l": "(9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14967", "l": "a carboxylate + H(+) + phosphate => an acyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72631", "l": "Formation of the cap-binding eIF4F complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396606", "l": "Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79106", "l": "L-histidine + taurocholate <=> L-histidocholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38275", "l": "(3R)-citramalyl-CoA = acetyl-CoA + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.46", "l": "\"(R)-citramalyl-CoA lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70227", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA = (E)-2-benzylidenesuccinyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.180", "l": "\"(E)-benzylidenesuccinyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163310", "l": "TFAM binds to mitochondrial promoters (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38869", "l": "pseudouridine(516) in 16S rRNA => uridine(516) in 16S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2430535", "l": "MASTL phosphorylates ENSA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432129", "l": "FGR binds and phosphorylates LRP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.3.9", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852552", "l": "MST1R autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30153", "l": "FAD + 2 H(+) + NADPH => FADH2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71084", "l": "estrone 3-sulfate(out) + 2 Na(+)(out) => estrone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70327", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) = 4-methylsulfanyl-2-oxobutanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.428", "l": "\"4-methylthio 2-oxobutanoate reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202713", "l": "CD84 homodimerises (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212222", "l": "PRC2 recruits DNA methyltransferases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74987", "l": "TTF-I binds to the Sal Box (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52630", "l": "a fatty acid + an L-alpha-amino acid => an N-fatty-acyl-L-alpha-amino acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822597", "l": "METTL23 and STGP4 (GSE) bind H3.3 dimethylarginine-17 (H3K17me2a) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65725", "l": "2-oxoglutarate + O2 + pentyl sulfate => CO2 + H(+) + pentanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0030228", "l": "lipoprotein particle receptor activity", "d": ["Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2255342", "l": "RALA exchanges GDP for GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33234", "l": "H2O2 + heme b <=> heme d cis-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37870", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA <=> 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5607734", "l": "PKC-delta translocates to plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088130", "l": "PLK1 binds FOXM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047032", "l": "3-alpha-hydroxyglycyrrhetinate dehydrogenase activity", "d": ["Catalysis of the reaction: 3alpha-hydroxyglycyrrhetinate + NADP+ = 3-oxoglycyrrhetinate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38948", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27974", "l": "6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.99.3", "l": "\"7-carboxy-7-deazaguanine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22109", "l": "L-threonine => 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27352", "l": "arsenate + mycothiol <=> arseno-mycothiol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210932", "l": "ANTXR2-bound pagA(197-794) forms oligomers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814695", "l": "PERP binds desmosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17739", "l": "3-dehydroshikimate + H(+) + NADPH => NADP(+) + shikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17972", "l": "ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790036", "l": "Expression of STAT3-upregulated nuclear proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60890", "l": "(N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102048", "l": "indole-3-acetyl-isoleucine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-isoleucine + ATP(4-) = H+ + indole-3-acetyl-isoleucine + AMP(2-) + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35750", "l": "(2E,6E)-farnesyl diphosphate <=> 7-epizingiberene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015485", "l": "cholesterol binding", "d": ["Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62129", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dGTP => a 2'-deoxyribonucleoside 5'-diphosphate + dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250947", "l": "B-WICH complex binds rDNA promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63877", "l": "2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 => (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48254", "l": "a ganglioside GD1b + H(+) + UDP => a ganglioside GD2 + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202713", "l": "CD84 homodimerises (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801687", "l": "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139941", "l": "Binding of IP3 to IP3 receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65671", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine <=> a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64534", "l": "an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O => an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26143", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O <=> 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854738", "l": "CSF3 dimer:CSFR binds CSFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.20", "l": "\"alpha-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605428", "l": "Expression of ESRRA (ERR1, ERRalpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2179274", "l": "SMURF2 binds SMAD3 phosphorylated in the linker region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65469", "l": "1-propanol + acetyl-CoA => CoA + propyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017005", "l": "3'-tyrosyl-DNA phosphodiesterase activity", "d": ["Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199144", "l": "Nectin 2 binds CD226 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0004535", "l": "poly(A)-specific ribonuclease activity", "d": ["Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42728", "l": "S-adenosyl-L-methionine + uridine(2791) in 21S rRNA = 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.168", "l": "\"21S rRNA (uridine(2791)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76935", "l": "2-methylpropan-1-amine + H2O + NAD(+) = 2-methylpropanal + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66122", "l": "(2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate => 2-oxobutanoate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4332359", "l": "Active calmodulin binds CAMK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912357", "l": "ITCH ubiquitinates DTX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71786", "l": "3-methyl-2-oxobutanoate(out) + H(+)(out) <=> 3-methyl-2-oxobutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-507875", "l": "Aquaporins passively transport urea into cells (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0008174", "l": "mRNA methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047956", "l": "glycerol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48754", "l": "CO2 + H(+) + succinate + validamycin B => 2-oxoglutarate + O2 + validamycin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635741", "l": "TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54731", "l": "acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] <=> malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990841", "l": "promoter-specific chromatin binding", "d": ["Binding to a section of chromatin that is associated with gene promoter sequences of DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.354970481220079", "identifiers": [{"i": "GO:0035250", "l": "UDP-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73797", "l": "FAICAR => IMP + H2O (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377644", "l": "Release of CSK from SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620663", "l": "EGR1 binds the VGF gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0005347", "l": "ATP transmembrane transporter activity", "d": ["Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-9717392", "l": "CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54655", "l": "peregrinol diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047594", "l": "6-beta-hydroxyhyoscyamine epoxidase activity", "d": ["Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = CO2 + H2O + H+ + scopolamine + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250280", "l": "ROS oxidize thioredoxin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60311", "l": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353277", "l": "Cleavage of thymine by 5-methylcytosine G/T mismatch specific glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2545253", "l": "Deacetylation of cohesin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12884", "l": "ADP-alpha-D-glucose + sn-glycerol 3-phosphate <=> 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951966", "l": "EP300 acetylates RUNX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23614", "l": "alpha-santonin + H(+) + NADH => 1,2-dihydro-alpha-santonin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27453", "l": "iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50727", "l": "(E)-4-hydroxyphenylacetaldehyde oxime <=> (Z)-(4-hydroxyphenyl)acetaldehyde oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141102", "l": "tRNA (5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: 5-carboxymethylaminomethyluridine34 in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine34 in tRNA(Leu) + H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.135", "l": "\"glyceollin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391211", "l": "Trace amine-associated receptors can bind trace amines (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691004", "l": "XPC binds RAD23 and CETN2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57612", "l": "20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH = 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32222", "l": "all-trans-lycopene <=> gamma-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876446", "l": "p-ULK1 phosphorylates DENND3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9761474", "l": "AMOT-2 binds CDH11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700981", "l": "TP53 family members bind the BAX promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835443", "l": "STAT1,STAT3 binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70894", "l": "L-asparagine(out) + L-glutamine(in) + Na(+)(out) <=> L-asparagine(in) + L-glutamine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11683", "l": "ATP + H2O + L-glutamine + XMP <=> AMP + diphosphate + GMP + 2 H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18720", "l": "3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22343", "l": "3-hydroxybenzyl alcohol + NADP(+) <=> 3-hydroxybenzaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31262", "l": "but-3-ynal + H2O + NAD(+) <=> 3-butynoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52990", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine => [deoxyhypusine synthase]-L-lysine + dehydrospermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60283", "l": "L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2404144", "l": "Parenchymal atROL translocates to HSCs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10836", "l": "NADPH + O2 + questin = demethylsulochrin + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.43", "l": "\"questin monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036426", "l": "ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity", "d": ["Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32946", "l": "a 1,2-diacyl-sn-glycerol + CDP-ethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295613", "l": "SPRY2 binds GRB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53506", "l": "5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52131", "l": "a 5'-end adenosine-5'-diphospho-5'-2'-deoxyribonucleoside-DNA + H2O <=> a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851866", "l": "MET binds RANBP10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029473", "l": "Branching and elongation of mother and daughter filaments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66247", "l": "ATP + H(+) + IC-asc-C9 <=> diphosphate + IC-asc-C9-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424481", "l": "Recruitment of VAV and BTK to p-SLP-76 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209227", "l": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050316", "l": "T2-induced deoxynucleotide kinase activity", "d": ["Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP + dTDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610757", "l": "GLI2 is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32282", "l": "allantoate + 2 H(+) + 2 H2O <=> (S)-ureidoglycolate + CO2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0016863", "l": "intramolecular oxidoreductase activity, transposing C=C bonds", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears."], "t": []}, {"i": "EC:5.3.3.-", "l": "\"Transposing C=C bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183055", "l": "Binding of CBL to EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67786", "l": "1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol => 2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33073", "l": "2-deoxy-L-scyllo-inosose + phosphate => D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19121", "l": "an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.6.2.3", "l": "\"ABC-type glutathione-S-conjugate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507871", "l": "Aquaporins passively transport glycerol out of cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38521", "l": "(9Z)-octadecenoate + 2-octadecanoylglycerol + H(+) => 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43848", "l": "[thioredoxin]-dithiol + arsenate + H(+) = [thioredoxin]-disulfide + arsenite + H2O", "d": [], "t": []}, {"i": "EC:1.20.4.4", "l": "\"arsenate reductase (thioredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627056", "l": "Procaspase 9 forms dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42742", "l": "H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625674", "l": "Defective SLC22A5 does not cotransport CAR, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660662", "l": "ASC binds Caspase-8 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11684", "l": "methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419451", "l": "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000286", "l": "alanine dehydrogenase activity", "d": ["Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964851", "l": "Dehydratation of DHQ yields DHS (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1449687", "l": "Corticosteroids bind to CBG in blood (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78440", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1,2-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33794", "l": "H2O + sucrose 6(F)-phosphate <=> beta-D-fructose + beta-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70413", "l": "4-hydroxyphenylacetate + CoA + H(+) => 4-hydroxyphenylacetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59559", "l": "H2O + N,N'-diacetylchitobiono-1,5-lactone <=> H(+) + N,N'-diacetylchitobionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19554", "l": "H2O + L-tryptophan => indole + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60125", "l": "pre-sodorifen diphosphate => diphosphate + sodorifen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62367", "l": "FMN-N(5)-peroxide + thymine <=> (Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944242", "l": "Association of procollagen type XXVII (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42155", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201453", "l": "Phospho-R-Smad1/5/8 dissociates from the receptor complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69446", "l": "alpha-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23957", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34687", "l": "AH2 + N-acyl-15-methylhexadecasphinganine + O2 = A + 2 H2O + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390425", "l": "FAR1 reduces PalmCoA to HXOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334827", "l": "SUMO-CRABP2 binds atRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-919404", "l": "Phosphorylated STAT5 is released (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54495", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine <=> 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66021", "l": "H2O2 + L-lysyl-[collagen] + L-methionyl-[collagen] => [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29747", "l": "3-phenylpropanoate(in) = 3-phenylpropanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5591052", "l": "PROCR binds Protein C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72283", "l": "a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40075", "l": "6-amino-6-deoxyfutalosine + H(+) + H2O = futalosine + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.40", "l": "\"aminodeoxyfutalosine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69140", "l": "RPA binds to the Flap (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10429", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66117", "l": "2-oxobutanoate + L-glutamine => (2S)-2-aminobutanoate + 2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.21", "l": "\"ADP-sugar diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72424", "l": "(E)-4-coumaroyl-AMP + CoA => (E)-4-coumaroyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371435", "l": "Constitutive phosphorylation by GSK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36929", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA => (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73854", "l": "27-hydroxywithanone + UDP-alpha-D-glucose <=> H(+) + UDP + withanone 27-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61191", "l": "quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose <=> H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19718", "l": "H(+) + L-phenylalanine => 2-phenylethylamine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43131", "l": "guanosine(10) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48542", "l": "dodecanoate + dodecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) => 1,2-didodecanoyl-3-beta-D-galactosyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877620", "l": "ECE2 cleaves EDN1(53-90) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71045", "l": "L-alanine(out) + L-phenylalanine(in) => L-alanine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12962", "l": "acetoacetate + butanoyl-CoA => acetoacetyl-CoA + butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33907", "l": "4-(methylamino)butanoate + H2O + O2 = 4-aminobutanoate + formaldehyde + H2O2", "d": [], "t": []}, {"i": "EC:1.5.3.19", "l": "\"4-methylaminobutanoate oxidase (formaldehyde-forming)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16219", "l": "H(+) + L-arabinonate => H2O + L-arabinono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55454", "l": "daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53045", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-ribonucleotide in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60303", "l": "N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44711", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003850", "l": "2-deoxyglucose-6-phosphatase activity", "d": ["Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24106", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine => 7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64109", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32505", "l": "(6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => linalool + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61690", "l": "AMP + diphosphate + L-threonyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483089", "l": "PE is converted to PS by PTDSS2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693540", "l": "MRN activates ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68776", "l": "(2Z,6Z)-farnesyl diphosphate = diphosphate + germacrene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205319", "l": "Interaction of APS and p-KIT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29610", "l": "H2O + NAD(+) + nitrous oxide <=> H(+) + NADH + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58454", "l": "H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29389", "l": "CDP + H(+) + phosphate => CTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45483", "l": "gamma-hexachlorocyclohexane <=> (3R,4S,5S,6R)-pentachlorocyclohexene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797974", "l": "LRRTMs bind NRXNs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453200", "l": "SYK autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69941", "l": "6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0046870", "l": "cadmium ion binding", "d": ["Binding to a cadmium ion (Cd)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17663", "l": "ADP + phosphate + succinyl-CoA => ATP + CoA + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45495", "l": "phycocyanobilin-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009072", "l": "STAT3 phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38969", "l": "ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate => an N-acylsphing-4-enine(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16749", "l": "H2O + phosphonoacetate = acetate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.11.1.2", "l": "\"phosphonoacetate hydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.-", "l": "\"Serine-type carboxypeptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63888", "l": "hexadecanoyl-CoA + sphinga-4E,14Z-dienine = CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76667", "l": "furfural + H2O + NAD(+) = 2-furoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168960", "l": "Collagen type XVII ectodomain shedding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071858", "l": "corazonin receptor binding", "d": ["Binding to a corazonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033730", "l": "arogenate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174235", "l": "Association of Emi1 with Cdc20 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24522", "l": "(S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH => H2O + L-saccharopine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4093327", "l": "EPHA binds TIAM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69932", "l": "inosine(out) + Na(+)(out) => inosine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16140", "l": "2'-deoxymugineate + NADP(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9856510", "l": "STARD7 transports Q10 to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950398", "l": "CANX dissociates from IL27:EBI3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12017", "l": "(2E,6E)-farnesyl diphosphate => (-)-germacrene D + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008793", "l": "aromatic-amino-acid:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981713", "l": "C4b binds to cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44961", "l": "(2E)-decenoyl-CoA + H(+) + NADPH => decanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47890", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204824", "l": "Interaction of Tie2 and Ang4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990631", "l": "ErbB-4 class receptor binding", "d": ["Binding to the protein-tyrosine kinase receptor ErbB-4/HER4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665410", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36211", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655170", "l": "RCHY1 monoubiquitinates POLH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59131", "l": "(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP <=> 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9853389", "l": "FIGNL1 binds RAD51 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22146", "l": "D-threo-isocitrate => cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174235", "l": "Association of Emi1 with Cdc20 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18153", "l": "2 GTP + H(+) = diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.45", "l": "\"guanosine-triphosphate guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11549", "l": "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O => 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5638006", "l": "ARL3 hydrolyzes GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12297", "l": "H2O + N-deacetylipecoside => dopamine + secologanin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015097", "l": "mercury ion transmembrane transporter activity", "d": ["Enables the transfer of mercury (Hg2+) ions from one side of a membrane to the other."], "t": []}, {"i": "RHEA:32815", "l": "Hg(2+)(in) = Hg(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873927", "l": "Release of STAT1 dimer from active receptor unit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193656", "l": "p75NTR interacts with RIP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37615", "l": "(9Z)-octadecenoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.045601261176557", "identifiers": [{"i": "GO:0000030", "l": "mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210426", "l": "Glutamate synaptic vesicle docking and priming (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41744", "l": "3'-phosphoadenylyl sulfate + a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11299", "l": "2,5-dioxopentanoate + H2O + NADP(+) <=> 2-oxoglutarate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64527", "l": "(2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA <=> 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38408", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O => (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17660", "l": "an acyl-CoA + dihydroxyacetone phosphate <=> a 1-acylglycerone 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995330", "l": "COX10 transforms heme to heme O (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0016815", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN."], "t": []}, {"i": "EC:3.5.5.-", "l": "\"In nitriles\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73797", "l": "FAICAR => IMP + H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73852", "l": "27-hydroxywithanone + UDP-alpha-D-glucose => H(+) + UDP + withanone 27-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19764", "l": "FMN-N(5)-oxide + H(+) + NADH <=> FMN + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001042", "l": "RNA polymerase I core binding", "d": ["Binding to a RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9612509", "l": "SGK phosphorylates SRF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865275", "l": "PDGF-BB clevage by Furin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13152", "l": "A + H(+) + NADPH <=> AH2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050105", "l": "L-gulonolactone oxidase activity", "d": ["Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15837", "l": "L-glutamate + methylamine = N-methyl-L-glutamate + NH4(+)", "d": [], "t": []}, {"i": "EC:2.1.1.21", "l": "\"methylamine--glutamate N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62561", "l": "(4R)-limonene + A + H2O => (4R)-perillyl alcohol + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12307", "l": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + L-2-aminoadipate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13342", "l": "a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682020", "l": "MRN complex binds shortened telomeres (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950128", "l": "Interleukin-12 dissociates from Interleukin-12 receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67808", "l": "L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937654", "l": "IL10 positively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.99", "l": "\"fatty acid amide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50419", "l": "L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] <=> H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41736", "l": "3'-phosphoadenylyl sulfate + a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) = adenosine 3',5'-bisphosphate + beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47344", "l": "7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684261", "l": "MAP3K8 is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54259", "l": "2-oxoglutarate + L-histidyl-[protein] + O2 <=> (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34418", "l": "(1R,4R)-bornane-2,5-dione + FMNH2 + O2 <=> (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781814", "l": "USP19 deubiquitinates RNF123 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825776", "l": "p-S742 TBX3 binds ID1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635845", "l": "GLI proteins bind CDC73 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017108", "l": "5'-flap endonuclease activity", "d": ["Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803999", "l": "HNO2 produces N2O3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018808", "l": "RAC3 binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44088", "l": "ATP + CoA + heptanoate = AMP + diphosphate + heptanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17366", "l": "ATP + H2O + Mn(2+)(out) => ADP + H(+) + Mn(2+)(in) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32998", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9823904", "l": "TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49544", "l": "(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O = 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35637", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP => an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9734540", "l": "ACLY tetramer binds ETC-1002-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31197", "l": "3-oxooctanoyl-CoA + H(+) + NADH => (3S)-hydroxyoctanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78576", "l": "(3S)-hydroxydocosanoyl-CoA => (2E)-docosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77861", "l": "(2S)-3-phenyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O2 => N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-phenylalanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72839", "l": "ADP(out) + CoA(in) = ADP(in) + CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990464", "l": "D-2-hydroxyacid dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016710", "l": "trans-cinnamate 4-monooxygenase activity", "d": ["Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46161", "l": "a quinone + H(+) + NADH => a quinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048032", "l": "galacturonate binding", "d": ["Binding to a galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50761", "l": "a quinone + H2O + sulfite => a quinol + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.36", "l": "\"RING-type E3 ubiquitin transferase (cysteine targeting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008215", "l": "RUNX2 binds GLI3R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11035", "l": "(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate <=> 3-chloro-cis,cis-muconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-532603", "l": "Nephrin mediated activation of N-WASP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052688", "l": "(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity", "d": ["Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + AMP + diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA."], "t": []}, {"i": "KEGG.REACTION:R06515", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39906", "l": "isoxazolin-5-one + O-acetyl-L-serine <=> 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.79", "l": "\"3beta,22alpha-dihydroxysteroid 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41754", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047286", "l": "NAD+-diphthamide ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36670", "l": "(15Z)-tetracosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39439", "l": "(3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA = (2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67211", "l": "H2O + melatonin <=> 5-methoxytryptamine + acetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39044", "l": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] => docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76494", "l": "(E)-ferulate + H2O <=> acetate + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41627", "l": "3-sulfinopropanoyl-CoA + H2O <=> H(+) + propanoyl-CoA + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022065", "l": "DSPGs are secreted (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9825772", "l": "SIRT1 deacetylates HINT1 dimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41401", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018846", "l": "styrene-oxide isomerase activity", "d": ["Catalysis of the reaction: styrene oxide = phenylacetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75212", "l": "Cu(+)(out) => Cu(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49828", "l": "(5E)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5E)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169192", "l": "PTP1B dephosphorylates GHR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913371", "l": "GM-CSF receptor alpha:GM-CSF binds Bc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9675026", "l": "Formation of the MLL1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354060", "l": "Translocation of RIAM to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23400", "l": "7,8-dihydroxykynurenate + O2 = 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.10", "l": "\"7,8-dihydroxykynurenate 8,8a-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174255", "l": "Degradation multiubiquitinated Cyclin A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60426", "l": "diphosphate + valerianol => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23446", "l": "H(+) + NADH + pyruvate => (S)-lactate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5688294", "l": "SIRT5 deacetylates Cytochrome C (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30928", "l": "2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O => 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701147", "l": "TRPV1 binds TRPV1 blockers (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693148", "l": "BCKDK phosphorylates BCKDH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818682", "l": "MEN1 binds MLL2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30313", "l": "formaldehyde + H2O + NAD(+) + xanthine => 7-methylxanthine + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682983", "l": "ATM phosphorylates WHSC1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49655", "l": "H(+) + NADH + O2 + protoviolaceinate <=> H2O + NAD(+) + violaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35275", "l": "3-hydroxyoctadecanoyl-CoA + NAD(+) = 3-oxooctadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38486", "l": "a 2,3-diacyl-sn-glycerol + H2O <=> a 2-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.154", "l": "\"sterol 14alpha-demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30434", "l": "(S)-2,3-epoxysqualene <=> taraxerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655955", "l": "OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727922", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to SMAD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23186", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate => (6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36129", "l": "O-methyl gibberellin A34 + S-adenosyl-L-homocysteine => gibberellin A34 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76371", "l": "n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16813", "l": "H2O + L-kynurenine = anthranilate + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47807", "l": "epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19955", "l": "an L-alpha-amino acid + pyruvate => a 2-oxocarboxylate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3341294", "l": "Superoxide reduces cytochrome c (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18684", "l": "phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine <=> phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944457", "l": "MAF1 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50683", "l": "H2O + N-terminal L-glutaminyl-[protein] <=> N-terminal L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74506", "l": "H(+) + NADPH + yaequinolone D <=> H2O + NADP(+) + penigequinolone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18404", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140107", "l": "high-affinity potassium ion transmembrane transporter activity", "d": ["Enables the transfer of potassium ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-398040", "l": "Gbeta:gamma activation of PLC beta (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252133", "l": "ATP6AP1 binds V-ATPase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15184", "l": "an acyl-CoA(out) + ATP + H2O <=> ADP + an acyl-CoA(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062124", "l": "4-hydroxybutyrate receptor activity", "d": ["Combining with 4-hydroxybutyrte to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15037", "l": "putrescine + S-adenosyl-L-methionine = H(+) + N-methylputrescine + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.53", "l": "\"putrescine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21312", "l": "2,5-dihydroxybenzoate + H(+) = CO2 + hydroquinone", "d": [], "t": []}, {"i": "EC:4.1.1.62", "l": "\"gentisate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48376", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013108", "l": "GDIs block activation of RHOC (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034246", "l": "mitochondrial transcription factor activity", "d": ["Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191402", "l": "Reduction of presqualene diphosphate to form squalene (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75714", "l": "a rhodoquinone + succinate <=> a rhodoquinol + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55680", "l": "(2S)-2-amino-4-deoxychorismate = anthranilate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392748", "l": "L1 binds to AP-2 Clathrin complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438026", "l": "Activation and dimerization of c-JUN in the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52977", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74437", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in) => a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944242", "l": "Association of procollagen type XXVII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71438", "l": "an aromatic L-alpha-amino acid(in) + L-thyroxine(out) <=> an aromatic L-alpha-amino acid(out) + L-thyroxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12458", "l": "CDP-L-ribitol + diphosphate => CTP + D-ribitol 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37603", "l": "(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11925", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => a globoside Gb3Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43886", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH => 3-oxochol-4-en-22-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-162657", "l": "Inactivation of Myt1 kinase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022886", "l": "channel-forming ionophore activity", "d": ["Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.57", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43696", "l": "H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate = diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}, {"i": "EC:2.7.4.27", "l": "\"([Pyruvate, phosphate dikinase] phosphate) phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31260", "l": "but-3-ynal + H2O + NAD(+) => 3-butynoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26091", "l": "H2O + limonene 1,2-epoxide + NAD(+) => (4S)-limonene + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420975", "l": "Ca impermeable AMPA receptor ligand binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21966", "l": "a carboxylate + choline + H(+) => an acylcholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849435", "l": "PTPN1 dephosphorylates PTK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49094", "l": "H(+) + hexadecanoate + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50650", "l": "2-(2-methylsulfanyl)ethylmaleate + H2O => 2-(2-methylsulfanyl)ethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78351", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46646", "l": "5beta-dihydrocortisol + NADP(+) => cortisol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53071", "l": "4-methoxyestrone + UDP-alpha-D-glucuronate <=> 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22271", "l": "ATP + streptomycin <=> ADP + H(+) + streptomycin 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934446", "l": "Activated PKC phosphorylates SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374337", "l": "Apelin receptor binds to apelin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24760", "l": "H(+) + L-dopa + NADH = 3-(3,4-dihydroxyphenyl)propanoate + NAD(+) + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.22", "l": "\"3,4-dihydroxyphenylalanine reductive deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77215", "l": "dATP + H2O = 2-deoxyribose 5-triphosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374663", "l": "DCC interaction with Ezrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15238", "l": "2 Fe(III)-[cytochrome c2] + NADPH => 2 Fe(II)-[cytochrome c2] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20663", "l": "2 D-alanine => D-alanyl-D-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77609", "l": "Binding of APOBEC-1 to form editosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45853", "l": "Co(II)-factor III + H(+) + S-adenosyl-L-methionine => Co(II)-factor IV + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69697", "l": "menadiol + NAD(+) => H(+) + menadione + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29407", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + NADPH + O2 = 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798743", "l": "Exocytosis of secretory granule membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67293", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one => (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202328", "l": "Translocation of PKC theta to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65116", "l": "2-oxoglutarate + aculene B + O2 = aculene A + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.147", "l": "\"22alpha-hydroxysteroid 23-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47412", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031829", "l": "type 4 serotonin receptor binding", "d": ["Binding to a type 4 serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74142", "l": "petunidin + UDP-alpha-D-glucose <=> petunidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956659", "l": "ABL1 phosphorylates YAP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11969", "l": "AH2 + kynurenate + O2 => 7,8-dihydro-7,8-dihydroxykynurenate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1470010", "l": "Dimerization of STATs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004650", "l": "polygalacturonase activity", "d": ["Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000120", "l": "CBLIF binds RCbl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9646468", "l": "mTORC1 binds RHEB:GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24964", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52301", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46340", "l": "ATP + N-hexadecanoylsphing-4-enine = ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6810376", "l": "ING2 binds PI5P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65093", "l": "asperaculane G + O2 + reduced [NADPH--hemoprotein reductase] => aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8955844", "l": "RBKS phosphorylates ribose to R5P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174159", "l": "Ubiquitination of Emi1 by SCF-beta-TrCP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55079", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) <=> 3-methylsulfanylpropanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004723", "l": "calcium-dependent protein serine/threonine phosphatase activity", "d": ["Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions."], "t": []}, {"i": "REACT:R-HSA-2025882", "l": "Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0098632", "l": "cell-cell adhesion mediator activity", "d": ["The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034893", "l": "N-nitrodimethylamine hydroxylase activity", "d": ["Catalysis of the reaction: N-nitrodimethylamine + O2 + 2 H+ + 2 e- = N-nitromethylamine + formaldehyde + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34127", "l": "(2E)-geranyl diphosphate + olivetolate = cannabigerolate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.102", "l": "\"geranylpyrophosphate--olivetolic acid geranyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21353", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 => (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56285", "l": "a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) => a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13530", "l": "(3S)-citramalate => H2O + mesaconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32032", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-curcumene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47871", "l": "di-(9Z)-octadecenoylglycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26270", "l": "Co-precorrin-2 + 3 H(+) => Co(2+) + precorrin-2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21178", "l": "5-dehydro-D-gluconate + H(+) + NADPH => L-idonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46226", "l": "(E)-ferulate + CoA + H(+) => (E)-feruloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035877", "l": "death effector domain binding", "d": ["Binding to a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27980", "l": "alpha-D-mannose 1-phosphate + GMP + 2 H(+) => GDP-alpha-D-mannose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.15", "l": "\"malonate-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77698", "l": "a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GM1alpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75163", "l": "NAD(+) + UTP = H(+) + NADP(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840564", "l": "OMA1 hydrolyzes YME1L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192677", "l": "Newly synthesized vRNP for export (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396370", "l": "VTN binds collagens II, III and V (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197690", "l": "Detachment of WASP/WAVE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42716", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + H2O + selenophosphate = (2E)-thiogeraniol + 5-methylaminomethyl-2-selenouridine(34) in tRNA + diphosphate + phosphate", "d": [], "t": []}, {"i": "EC:2.9.1.3", "l": "\"tRNA 2-selenouridine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68756", "l": "4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3782655", "l": "HDAC10 deacetylates histone (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080018", "l": "anthocyanin 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: an anthocyanin + UDP-D-glucose = an anthocyanin-5-O-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52408", "l": "4-phospho-D-erythronate + NAD(+) = CO2 + dihydroxyacetone phosphate + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.409", "l": "\"4-phospho-D-erythronate 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64660", "l": "a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733766", "l": "MESP1 binds the GATA4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951951", "l": "RUNX3 binds EP300 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033982", "l": "3-dehydro-L-gulonate-6-phosphate decarboxylase activity", "d": ["Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H+ = L-xylulose 5-phosphate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46200", "l": "5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51208", "l": "20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38418", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55881", "l": "apo-[aequorin]--coelenterazine + O2 => [aequorin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008693", "l": "(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71758", "l": "2-oxoglutarate(out) + 2-oxoheptanedioate(in) <=> 2-oxoglutarate(in) + 2-oxoheptanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19906", "l": "NAD(+) + spermidine => dehydrospermidine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21647", "l": "ATP + glycerol <=> ADP + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050628", "l": "2-oxopropyl-CoM reductase (carboxylating) activity", "d": ["Catalysis of the reaction: acetoacetate + coenzyme M + NADP+ = 2-oxopropyl-coenzyme M + CO2 + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709273", "l": "BRCA2 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40588", "l": "H2O + octanedioyl-CoA => CoA + H(+) + octanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050157", "l": "ornithine racemase activity", "d": ["Catalysis of the reaction: L-ornithine = D-ornithine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202489", "l": "Oligomerization of Bcl10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200555", "l": "Formation of Malonyl-CoA from Acetyl-CoA (liver) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76099", "l": "a dicarboxylate(in) + xanthurenate(out) = a dicarboxylate(out) + xanthurenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50840", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018782", "l": "cis-chloroacrylic acid dehalogenase activity", "d": ["Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948703", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604732", "l": "Autocatalytic activation of proMMP13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47034", "l": "2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein] => AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696213", "l": "AS3MT transfers CH3 from AdoMet to methylarsonite (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-392834", "l": "Activation of EPACs by cAMP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78432", "l": "1-O-alkyl-2-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27557", "l": "all-trans-hexaprenyl diphosphate + 2 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57404", "l": "NAD(+) + narcotine hemiacetal = H(+) + NADH + noscapine", "d": [], "t": []}, {"i": "EC:1.1.1.415", "l": "\"noscapine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030626", "l": "U12 snRNA binding", "d": ["Binding to a U12 small nuclear RNA (U12 snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015133", "l": "uronic acid transmembrane transporter activity", "d": ["Enables the transfer of uronic acid from one side of a membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005298", "l": "proline:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647660", "l": "GSDME (1-270) binds PIPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69187", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-glycerol 1-phosphate <=> diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450031", "l": "Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67750", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62035", "l": "a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O <=> a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75943", "l": "beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004099", "l": "chitin deacetylase activity", "d": ["Catalysis of the reaction: chitin + H2O = chitosan + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76191", "l": "carnosine(out) + 2 H(+)(out) = carnosine(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674132", "l": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047643", "l": "alginate synthase activity", "d": ["Catalysis of the reaction: GDP-D-mannuronate + alginate(n) = GDP + alginate(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74035", "l": "D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63177", "l": "(2S)-ibuprofenoyl-CoA => (2R)-ibuprofenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655142", "l": "RCHY1 binds POLH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607734", "l": "PKC-delta translocates to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818501", "l": "DPPA3 binds UHRF1, displacing UHRF1 from chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19384", "l": "(S)-oxalosuccinate + H(+) <=> 2-oxoglutarate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.98.2", "l": "\"dichlorochromopyrrolate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38108", "l": "2-dehydro-3-deoxy-L-galactonate => L-glyceraldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24466", "l": "D-glyceraldehyde 3-phosphate + pyruvate => 2-dehydro-3-deoxy-6-phospho-D-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653974", "l": "Ragulator binds Rag dimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428123", "l": "KDSR reduces 3-ketosphingoid (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62589", "l": "2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) => 4-hydroxybenzyl alcohol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61479", "l": "a sphingoid base + octadecanoyl-CoA <=> an N-octadecanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000773", "l": "phosphatidyl-N-methylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16100", "l": "acetylpyruvate + H2O <=> acetate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251942", "l": "Hikeshi binds HSP70s:ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944266", "l": "Association of procollagen type XI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41806", "l": "(3R)-hydroxybutanoyl-[ACP] + NADP(+) => 3-oxobutanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858252", "l": "HDLBP binds HDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45230", "l": "a 4-saturated (2E)-enoyl-CoA => a (3E)-enoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114553", "l": "Activation of conventional Protein Kinase C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249378", "l": "STING recruits TBK1 and STAT6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60661", "l": "1,4-benzoquinone + H(+) + NADH => hydroquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40350", "l": "3-oxotetradecanedioyl-CoA + CoA <=> acetyl-CoA + dodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5444516", "l": "Formation of MSH2:MSH6 Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661419", "l": "ALB binds extracellular heme (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975594", "l": "PLB1 hydrolyses RPALM to atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196017", "l": "Dynamin is recruited to the gap junction plaque (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74234", "l": "H2O + L-threonyl-tRNA(Val) <=> L-threonine + tRNA(Val)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70546", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6797100", "l": "CCNK binds CDK13 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54176", "l": "a long-chain fatty aldehyde + holo-[ACP] + NADP(+) = a long-chain fatty acyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13405", "l": "4-coumaroyl-CoA + agmatine = CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide", "d": [], "t": []}, {"i": "EC:2.3.1.64", "l": "\"agmatine N(4)-coumaroyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39822", "l": "docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57387", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA <=> (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111879", "l": "PIP2 hydrolysis (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23003", "l": "(R)-pantoate + NAD(+) <=> (R)-4-dehydropantoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9839390", "l": "TGFBR3 complex binds to TGFBR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58376", "l": "decan-1-ol + NADP(+) = decanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.36", "l": "\"caspase-1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48402", "l": "CO2 + succinate + trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] => 2-oxoglutarate + L-prolyl-[hypoxia-inducible factor alpha subunit] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004310", "l": "farnesyl-diphosphate farnesyltransferase activity", "d": ["Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28991", "l": "N-acetylneuraminate(in) = N-acetylneuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47772", "l": "a guanosine in 21S rRNA + S-adenosyl-L-methionine = a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755545", "l": "Defective DHDDS does not elongate E,E-FPP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399928", "l": "Recruitment of Rnd1 to Plexin A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698758", "l": "FLT3 ITD- and NOX4-dependent H2O2 production (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39002", "l": "a 1-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41719", "l": "a 2-acyl-sn-glycero-3-phospho-L-serine + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.8", "l": "\"heparin-sulfate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5605147", "l": "Defective CYP1B1 does not 4-hydroxylate EST17b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26142", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+) => 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694392", "l": "3a translocates to the ERGIC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66685", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[GAPDH] => L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4608855", "l": "PRICKLE1 is degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696958", "l": "USP44 deubiquitinates CDC20 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37778", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA <=> 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74734", "l": "rhamnetin + S-adenosyl-L-methionine <=> 7,4'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700648", "l": "Active ALK binds SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839377", "l": "TGFB1,TGFB2 bind TGFBR3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.3.-", "l": "\"With reduced pteridine as one donor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44585", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50971", "l": "adenosine(37) in tRNA(Ala) + H(+) + H2O <=> inosine(37) in tRNA(Ala) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663252", "l": "NR1D1 (REV-ERBA) binds heme, the ELOVL3 gene, and recruits corepressors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669906", "l": "Ligand-independent dimerization of KIT juxtamembrane domain mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66536", "l": "A + cholest-4,6-dien-3-one + H2O = 25-hydroxycholest-4,6-dien-3-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10789", "l": "2-dehydro-D-gluconate + ATP => 6-phospho-2-dehydro-D-gluconate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56930", "l": "abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322434", "l": "XIAP dissociates from ub-TLE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59863", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60903", "l": "a cytidine in RNA + S-adenosyl-L-methionine <=> an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:1990042", "l": "glycerol dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which glycerol is converted into glycerone and NAD+ or NADP is reduced."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42397", "l": "cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine => 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1964496", "l": "STING binds TRIM32 or TRIM56  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9839358", "l": "Endocytosis of TGFBR3:ARRB complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15936", "l": "(S)-propane-1,2-diol + NAD(+) <=> (S)-lactaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40856", "l": "FAD + H(+) + undecanoyl-CoA => FADH2 + trans-2-undecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392874", "l": "Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14472", "l": "2-aminomuconate 6-semialdehyde + H2O + NAD(+) <=> (2Z,4E)-2-aminomuconate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63736", "l": "2-phenylacetaldehyde + H(+) + NADPH = 2-phenylethanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10555", "l": "D-glucose + O2 <=> 2-dehydro-D-glucose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29872", "l": "ATP + H2O + thiosulfate(out) => ADP + H(+) + phosphate + thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036239", "l": "taxoid 7beta-hydroxylase activity", "d": ["Catalysis of the reaction: taxusin + [reduced NADPH-hemoprotein reductase] + O2 = 7beta-hydroxytaxusin + [oxidized NADPH-hemoprotein reductase] + H2O and 2alpha-hydroxytaxusin + [reduced NADPH-hemoprotein reductase] + O2 = 2alpha,7beta-dihydroxytaxusin + [oxidized NADPH-hemoprotein reductase] + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17456", "l": "5-phospho-beta-D-ribosylamine + ATP + glycine <=> ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102235", "l": "1-penten-3-one reductase activity", "d": ["Catalysis of the reaction: 1-penten-3-one + NADPH + H+ = 1-pentan-3-one + NADP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29769", "l": "ADP + D-methionine(in) + H(+) + phosphate => ATP + D-methionine(out) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67324", "l": "acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine = (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75014", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate <=> 2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8979082", "l": "Phosphorylated ETS2 binds p16INK4A promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35277", "l": "3-oxooctadecanoyl-CoA + H(+) + NADH => 3-hydroxyoctadecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014296", "l": "RAC2 GEFs activate RAC2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878914", "l": "B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442749", "l": "CaMKK autophosphorylates in the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1295632", "l": "PPA2A dephosphorylates SPRY2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39813", "l": "18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28381", "l": "ATP + N(6)-(D-fructosyl)-L-lysine <=> ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854981", "l": "SHC1 in the RET complex is phosphorylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932400", "l": "MYC:MAX binds the CDC25A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15761", "l": "L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71064", "l": "L-arginine(in) + L-histidine(out) => L-arginine(out) + L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74892", "l": "CO2(out) => CO2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102406", "l": "omega-hydroxypalmitate O-sinapoyl transferase activity", "d": ["Catalysis of the reaction: sinapoyl-CoA + 16-hydroxypalmitate = coenzyme A + 16-sinapoyloxypalmitate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36136", "l": "(2E)-hexadecenal + H2O + NAD(+) => (E)-hexadec-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981657", "l": "IL34 dimer binds PTPRZ1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44616", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H2O = 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71170", "l": "glycine(out) + H(+)(in) + Na(+)(out) <=> glycine(in) + H(+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432535", "l": "TIM is phosphorylated by CK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200555", "l": "Formation of Malonyl-CoA from Acetyl-CoA (liver) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655832", "l": "Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362522", "l": "ALDHs oxidise atRAL to atRA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72310", "l": "L-glutamate(in) + taurocholate(out) <=> L-glutamate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784598", "l": "NPPA(124-151) binds NPR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709883", "l": "BIL:ALB scavenges O2.- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54585", "l": "a guanosine in 18S rRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59996", "l": "3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] = (E)-cinnamate + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49170", "l": "8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005980", "l": "IL21 binds IL21R:JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373748", "l": "SEMA4D interacts with CD72 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59197", "l": "holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP => AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77688", "l": "a ganglioside GD1a (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => a ganglioside GalNAc-GD1a (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-76416", "l": "Benzene is hydroxylated to phenol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16915", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78414", "l": "carbendazim + H2O <=> 2-aminobenzimidazole + CO2 + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49177", "l": "12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55561", "l": "a hydroperoxyeicosatetraenoate => a hydroxy-epoxy-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17655", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + diphosphate => (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64572", "l": "isopentenyl diphosphate + neryl diphosphate = (2Z,6Z)-farnesyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70767", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373736", "l": "Shootin-1 links L1 and retrograde actin flow (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27460", "l": "3-iodo-L-tyrosine + iodide + NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13216", "l": "H2O + NADP(+) + succinate semialdehyde <=> 2 H(+) + NADPH + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450348", "l": "Activated human JNKs migrate to nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24313", "l": "L-lysyl-[cytochrome c] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75090", "l": "32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700175", "l": "Active ALK phosphorylates SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43092", "l": "S-adenosyl-L-methionine + uridine(2479) in 23S rRNA = 2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.208", "l": "\"23S rRNA (uridine(2479)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75101", "l": "(4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside + UDP => (4Z,15Z)-bilirubin IXalpha + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65907", "l": "3-hydroxy-L-kynurenine + glyoxylate <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32083", "l": "CTP + pseudaminate = CMP-pseudaminate + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.81", "l": "\"pseudaminic acid cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19265", "l": "carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.108", "l": "\"carnitine 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72912", "l": "proatranorin III + S-adenosyl-L-methionine => atranorin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3159253", "l": "MMAB adenosylates cob(I)alamin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63386", "l": "1-O-octadecyl-2-acetyl-sn-glycerol + H(+) + phosphocholine => 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112690", "l": "PTPN11 binds CBL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41601", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19765", "l": "glycerol = 3-hydroxypropanal + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.30", "l": "\"glycerol dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34055", "l": "festuclavine + NAD(+) = 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.5.1.44", "l": "\"festuclavine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32338", "l": "(1S,2S,4R)-endo-fenchol + NADP(+) <=> (1S,4R)-fenchone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22998", "l": "2 H2O + L-dehydroascorbate => H2O2 + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72095", "l": "Internal Methylation of mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804266", "l": "CHEK2 phosphorylates TTC5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139893", "l": "Granzyme-B activates BID by cleavage (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63817", "l": "ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine => AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45783", "l": "(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197690", "l": "Detachment of WASP/WAVE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007447", "l": "E2F6 forms the PRC1L4 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25649", "l": "(2R,5R)-isopulegone + NADP(+) = (6R)-isopiperitenone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.82", "l": "\"(-)-isopiperitenone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47084", "l": "4-methylsulfanyl-2-oxobutanoate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445079", "l": "Phosphorylation of L1 by ERK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42920", "l": "S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.193", "l": "\"16S rRNA (uracil(1498)-N(3))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74764", "l": "rhamnetin + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29238", "l": "a menaquinone + H(+) + NADH <=> a menaquinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17408", "l": "N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine <=> H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36014", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016501", "l": "prostacyclin receptor activity", "d": ["Combining with prostacyclin (PGI(2)) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52161", "l": "(E)-phenylacetaldehyde oxime => (Z)-phenylacetaldehyde oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53449", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49290", "l": "AMP + diphosphate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] => (R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72911", "l": "proatranorin III + S-adenosyl-L-methionine = atranorin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70095", "l": "(R)-5-methyl-tetronate + o-quinone methide = peniphenone D", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27724", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP => di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50958", "l": "H(+) + N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687095", "l": "p-S215 FOXO3 binds MIR34B and C gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54147", "l": "2 2-oxoglutarate + 5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 O2 <=> 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 CO2 + H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55603", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose <=> a mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52689", "l": "3-phenyllactate + NAD(+) => 3-phenylpyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602603", "l": "IRAK4 deficiency blocks formation of the MyD88-IRAK4 Myddosome in the TLR5 pathway (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6790487", "l": "RNF111 ubiquitinates SUMOylated XPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62995", "l": "H2O + tetradecamide <=> NH4(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43144", "l": "adenosine(22) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.217", "l": "\"tRNA (adenine(22)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78269", "l": "a dicarboxylate + CoA + H(+) => H2O + omega-dicarboxyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35073", "l": "4-methylphenol(out) => 4-methylphenol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55175", "l": "2-oxoglutarate + hexanoyl-CoA + O2 <=> 2-hydroxyhexanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033923", "l": "glucan 1,6-alpha-isomaltosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0016906", "l": "sterol 3-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51745", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A => a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57050", "l": "2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase] => AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74449", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0141056", "l": "histone H4 ubiquitin ligase activity", "d": ["Catalysis of the transfer of ubiquitin to a histone H4 substrate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38339", "l": "(20S)-ginsenoside Rb1 + H2O = (20S)-ginsenoside Rd + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.195", "l": "\"20-O-multi-glycoside ginsenosidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39250", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA <=> (2E,11Z)-eicosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701147", "l": "TRPV1 binds TRPV1 blockers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5674140", "l": "PAQR3 binds inactive RAFs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63436", "l": "1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63176", "l": "(2S)-ibuprofenoyl-CoA = (2R)-ibuprofenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11122", "l": "2 CO2 + NH4(+) => cyanate + 3 H(+) + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69756", "l": "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3786258", "l": "TP53 binds the CDKN1A promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46338", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA => 3-oxochola-4,17-dien-22-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54292", "l": "ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48347", "l": "an N-acyl-sphingoid base + UDP-alpha-D-galactose <=> a D-galactosylceramide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23247", "l": "propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + norspermidine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12180", "l": "anthranilate + S-adenosyl-L-methionine = H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.111", "l": "\"anthranilate N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70564", "l": "H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607734", "l": "PKC-delta translocates to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41004", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694583", "l": "ABHD4 hydrolyses NAPE (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809707", "l": "MTMR12 binds MTMR2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651773", "l": "LIG1 binds POLB at long-patch BER site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.02616462956729", "identifiers": [{"i": "GO:0019887", "l": "protein kinase regulator activity", "d": ["Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10644", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H2O = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.57", "l": "\"2-pyrone-4,6-dicarboxylate lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16741", "l": "a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.22", "l": "\"2-acylglycerol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030527", "l": "structural constituent of chromatin", "d": ["The action of a molecule that contributes to the structural integrity of chromatin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509831", "l": "ITPA hydrolyses XTP to XMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804229", "l": "JMY, TTC5 and EP300 bind (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10712", "l": "L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O", "d": [], "t": []}, {"i": "EC:1.13.12.9", "l": "\"phenylalanine 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-947535", "l": "Cyclisation of GTP to precursor Z (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17482", "l": "2 cob(I)alamin + H(+) + NAD(+) => 2 cob(II)alamin + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46507", "l": "dodecanoyl-AMP + holo-[ACP] <=> AMP + dodecanoyl-[ACP] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15473", "l": "flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose = flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.236", "l": "\"flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801195", "l": "STEAP3 binds BNIP3L (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19737", "l": "4-(gamma-L-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:3.5.1.94", "l": "\"gamma-glutamyl-gamma-aminobutyrate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68668", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47141", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9638090", "l": "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51698", "l": "H(+) + S-adenosyl-L-homocysteine + xanthohumol => desmethylxanthohumol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64014", "l": "A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine => acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0036455", "l": "iron-sulfur transferase activity", "d": ["Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor)."], "t": []}, {"i": "REACT:R-HSA-2564828", "l": "CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19083", "l": "a halide anion + a primary alcohol + H(+) => 1-haloalkane + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106266", "l": "3-chloro THPH synthase activity", "d": ["Catalysis of the reaction: 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H+ + 2 H2O."], "t": []}, {"i": "RHEA:64356", "l": "2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080083", "l": "beta-gentiobiose beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of glucosidic link in beta-gentiobiose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15776", "l": "ATP + dihydroxyacetone <=> ADP + dihydroxyacetone phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3159259", "l": "MMAA:MUT binds AdoCbl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015426", "l": "ATPase-coupled polar amino acid-transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665232", "l": "Resistant ERBB2 KD mutants do not bind trastuzumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033772", "l": "flavonoid 3',5'-hydroxylase activity", "d": ["Catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O, and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174551", "l": "Formation of alternative pathway C5 convertase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985929", "l": "IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36996", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37473", "l": "CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine => 3-methylbutanoyl-CoA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43653", "l": "decanoyl-CoA + H(+) + malonyl-[ACP] => 3-oxododecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24923", "l": "L-homoserine = 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48624", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141089", "l": "glucose sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38561", "l": "(R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047370", "l": "succinate-citramalate CoA-transferase activity", "d": ["Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1013020", "l": "Activation of GIRK/Kir3 Channels (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12480", "l": "5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.43", "l": "\"aminolevulinate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37957", "l": "(8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24539", "l": "L-tryptophan + O2 <=> N-formyl-L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202709", "l": "JAM2 dimerises (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34600", "l": "15-methylhexadecasphinganine + NADP(+) => 3-dehydro-15-methylhexadecasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944257", "l": "Association of procollagen type XXIV (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218804", "l": "p38 MAPK activation by VEGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77715", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(3)-alpha-NeuNAc,III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048101", "l": "calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity", "d": ["Catalysis of the reactions: nucleoside 3',5'-cyclic GMP + H2O = GMP + H+; this activity is activated by binding to calcium-bound calmodulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218812", "l": "FYN phosphorylates PAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57305", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GMP => glycolate + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65997", "l": "Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+) => methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357479", "l": "p-AXL binds PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48605", "l": "2,3-dihydroxybenzoyl-5'-AMP + holo-[ACP] => 2,3-dihydroxybenzoyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655142", "l": "RCHY1 binds POLH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48671", "l": "20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53931", "l": "a tertiary amine + S-adenosyl-L-methionine <=> a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0003730", "l": "mRNA 3'-UTR binding", "d": ["Binding to a 3' untranslated region of an mRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26043", "l": "acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-9-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64574", "l": "(2Z,6Z)-farnesyl diphosphate + diphosphate => isopentenyl diphosphate + neryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140211", "l": "folic acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: folic acid(out) + H+(out) = folic acid(in) + H+(in). The main folic acid symporter is the Proton-Coupled Folate Transporter (PCFT/SLC46A1), which has similar affinity for transport of reduced folates (5-methyl THF, 5-formyl THF) and folic acid."], "t": []}, {"i": "TCDB:2.A.1.50.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34517", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP => tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65085", "l": "asperaculane E + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aculene D + CO2 + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36472", "l": "3,4,5-trihydroxybenzoate(out) + H(+)(out) => 3,4,5-trihydroxybenzoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71270", "l": "chloride(out) + L-pipecolate(out) + 2 Na(+)(out) <=> chloride(in) + L-pipecolate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13423", "l": "an N-acylneuraminate 9-phosphate + phosphate => an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34547", "l": "ATP + cob(II)yrinate + H2O + L-glutamine = ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9709098", "l": "DHFR dimer reduces FOLA to DHF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29034", "l": "L-glutamate(in) + 2 Na(+)(in) <=> L-glutamate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173636", "l": "Formation of classic pathway C5 convertase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73909", "l": "ADP + aeruginascin + H(+) => 4-hydroxy-N,N,N-trimethyltryptamine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10388", "l": "GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72127", "l": "agmatine(in) + H(+)(out) = agmatine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12742", "l": "ADP + H(+) + H2O => IDP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58761", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH => 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1462023", "l": "Pre-pro-defensins are cleaved to remove the signal peptide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.11", "l": "\"gamma-D-glutamyl-meso-diaminopimelate peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30866", "l": "4-O-phospho-L-tyrosine + H2O <=> L-tyrosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55446", "l": "cochalate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + oleanolate + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.045601261176557", "identifiers": [{"i": "GO:0008443", "l": "phosphofructokinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70692", "l": "ornithine => putrescine + CO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30738", "l": "1D-myo-inositol 4-phosphate + H2O <=> myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58684", "l": "FAD + 2 H(+) + NADPH + O2 = FADH2-C4alpha-hydroperoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44815", "l": "1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-11 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53171", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047469", "l": "4-carboxymethyl-4-methylbutenolide mutase activity", "d": ["Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31451", "l": "2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102802", "l": "thebaine 6-O-demethylase activity", "d": ["Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 = neopinone + formaldehyde + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452097", "l": "Recruited STAT5 is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690196", "l": "USP8 deubiquitinates RNF128 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25339", "l": "H(+) + urea => isocyanate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051430", "l": "corticotropin-releasing hormone receptor 1 binding", "d": ["Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26198", "l": "H2O + melamine => ammeline + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691167", "l": "CUL1, SKP1, FBXL5 bind (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65699", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine <=> a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69414", "l": "glutathione disulfide + H2O + tert-butanol => 2 glutathione + tert-butyl hydroperoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58011", "l": "(20S)-ginsenoside F1 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rg1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66609", "l": "(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O => GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64667", "l": "a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12804", "l": "ATP + L-seryl-[tau protein] <=> ADP + H(+) + O-phospho-L-seryl-[tau protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24335", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate <=> H2O + monacolin L carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.359", "l": "\"aldose 1-dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781905", "l": "ZRANB1 binds APC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432148", "l": "Fgr may phosphorylate p38 MAPK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72075", "l": "ATP + gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine = ADP + H(+) + ophthalmate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54896", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate + ATP + CoA = (10Z,15Z)-12-oxophytodienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70304", "l": "beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48222", "l": "(2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35308", "l": "H(+) + NADH + O2 + salicylate => 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956365", "l": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28093", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61911", "l": "2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol <=> 2 AMP + asperphenamate + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49797", "l": "an N-(fatty acyl)-glycine + H2O => a fatty acid + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380316", "l": "Association of NuMA with microtubules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41918", "l": "3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + hexadecanoyl-[ACP] + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43113", "l": "(R)-mandelate + NAD(+) => H(+) + NADH + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40879", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9865309", "l": "MT-CO1 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683774", "l": "p-T68-CHEK2 dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381727", "l": "RAP1A exchanges GDP for GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53139", "l": "(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) <=> 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61190", "l": "H(+) + quercetin 3-O-beta-D-glucoside-7-O-alpha-L-rhamnoside + UDP => quercetin 3-O-beta-D-glucoside + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73972", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65684", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine = a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008220", "l": "Expression of globin genes under control of the beta globin control region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43762", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12] => acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71338", "l": "chloride(out) + L-tryptophan(out) + 2 Na(+)(out) <=> chloride(in) + L-tryptophan(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28773", "l": "(9Z)-hexadecenoyl-CoA => (2E)-hexadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14178", "l": "(R)-amygdalin + H2O => (R)-prunasin + D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229132", "l": "AP4 binds APP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954117", "l": "E2F6:TFDP1 binds EPC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52254", "l": "2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine => a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.15", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802912", "l": "High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30172", "l": "hexadecanoyl-[ACP] + sn-glycerol 3-phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78442", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1,2-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19044", "l": "(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77247", "l": "H2O + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.52", "l": "\"[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25765", "l": "3-carboxy-2-oxobutanoate + H(+) + NADH => (2R,3S)-3-methylmalate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54035", "l": "(6R)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose <=> (6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55924", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52065", "l": "13-(9Z-octadecenoyloxy)-octadecanoate + H2O => (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25770", "l": "3-carboxy-2-oxobutanoate + H(+) <=> 2-oxobutanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47410", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA => (24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23108", "l": "D-arabinono-1,4-lactone + H2O = D-arabinonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30931", "l": "L-cysteine + O-acetyl-L-homoserine = acetate + H(+) + L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41316", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140813", "l": "urate:monoatomic anion antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urate(out) + anion (in) = urate (in) + anion (out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750942", "l": "USP14 deubiquitinates NLRC5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112429", "l": "Formation of FACT complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939039", "l": "PPANT translocates from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17837", "l": "2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.63", "l": "\"2-carboxy-D-arabinitol-1-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37851", "l": "13-deoxydaunorubicin + H(+) + NADPH + O2 = 13-dihydrodaunorubicin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78751", "l": "(R)-carnitine + a fatty acyl-CoA = a fatty acyl-L-carnitine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047303", "l": "glycine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction: glycine + oxaloacetate = L-aspartate + glyoxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37446", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25625", "l": "H2O + histamine + O2 = H2O2 + imidazole-4-acetaldehyde + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.3.22", "l": "\"diamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0036002", "l": "pre-mRNA binding", "d": ["Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018462", "l": "4-(hydroxymethyl)benzenesulfonate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD+ = 4-formylbenzenesulfonate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218804", "l": "p38 MAPK activation by VEGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33642", "l": "ATP + CoA + tetracosanoate <=> AMP + diphosphate + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047109", "l": "(S)-3-hydroxyacid-ester dehydrogenase activity", "d": ["Catalysis of the reaction: ethyl (S)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63677", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16998", "l": "3'-phosphoadenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol => 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9650473", "l": "SERPING1 is secreted (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710988", "l": "SARS-CoV-1 M protein interacts with TBK1/IKBKE  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0004344", "l": "glucose dehydrogenase activity", "d": ["Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32932", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol => a cardiolipin + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50867", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35386", "l": "precorrin-6B + S-adenosyl-L-methionine <=> CO2 + H(+) + precorrin-7 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044604", "l": "ABC-type phytochelatin transporter activity", "d": ["Enables the directed movement of a phytochelatin from one side of a membrane to the other. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426209", "l": "DAG activation of TRPC channels (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197698", "l": "Src phosphorylate WASP,N-WASP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16860", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine <=> an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43663", "l": "ATP + hydrogencarbonate + propanoyl-CoA <=> ADP + H(+) + methylmalonyl-CoA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77535", "l": "H2O + L-methionyl-tRNA(Leu) = H(+) + L-methionine + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56101", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) => [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46140", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69539", "l": "alpha-D-tagatopyranose 1-phosphate + ATP <=> ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51605", "l": "2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] => 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9845538", "l": "ST3GAL2,3 transfer Neu5Ac to gangliosides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0120108", "l": "DNA-3'-diphospho-5'-guanosine diphosphatase", "d": ["Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H2O = (DNA)-3'-phosphate + GMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981621", "l": "Neuroglobin:oxygen dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58413", "l": "3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] => H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443774", "l": "Trans-homodimerization of Neurofascin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50515", "l": "acetyl-CoA + N-terminal L-cysteinyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71956", "l": "glutarate(out) + 3 Na(+)(out) => glutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070337", "l": "3'-flap-structured DNA binding", "d": ["Binding to a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16327", "l": "diphosphate + UDP-alpha-D-glucuronate => 1-phospho-alpha-D-glucuronate + H(+) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10940", "l": "(2E)-geranyl diphosphate = (4R)-limonene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.20", "l": "\"(R)-limonene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43297", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26070", "l": "CoA + H(+) + phosphinomethylmalate => 3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177284", "l": "PKA phosphorylates PDE4B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41706", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59073", "l": "AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + A + cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate) + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685603", "l": "SAP and EAT2 binds SLAMF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18184", "l": "acetyl-CoA + glyoxylate + H2O <=> (S)-malate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36525", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33227", "l": "(E)-4-coumarate + H(+) = 4-hydroxystyrene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10179", "l": "(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37780", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433456", "l": "Recruitment of STATs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103033", "l": "beta-galactosidase activity (lactose isomerization)", "d": ["Catalysis of the reaction: alpha-lactose = beta-(1->6)-galactobiose."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.1", "l": "\"P-type phospholipid transporter\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1013020", "l": "Activation of GIRK/Kir3 Channels (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16353", "l": "2-oxoglutarate + taurine = L-glutamate + sulfoacetaldehyde", "d": [], "t": []}, {"i": "EC:2.6.1.55", "l": "\"taurine--2-oxoglutarate transaminase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67894", "l": "3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26508", "l": "(9Z)-octadecenoate + NH4(+) => (9Z)-octadecenamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71454", "l": "bradykinin + H2O <=> bradykinin(1-7) + L-Phe-L-Arg", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13735", "l": "an alk-2-enal + H(+) + NADH => an n-alkanal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109639", "l": "Formation of the closed pre-initiation complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49067", "l": "2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol <=> calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67840", "l": "a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381727", "l": "RAP1A exchanges GDP for GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37064", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22237", "l": "2-deoxy-D-glucose 6-phosphate + H2O => 2-deoxy-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75557", "l": "erinacol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-cyatha-3,12-diene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.10", "l": "\"acrosin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-517674", "l": "p-S158,221-HuR binds mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61759", "l": "stevioside + UDP-alpha-D-glucose <=> H(+) + rebaudioside A + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009027", "l": "tartrate dehydrogenase activity", "d": ["Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46309", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] => 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39965", "l": "glycerol + H(+) + hexadecanoate => 2-hexadecanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75075", "l": "dihydro-6-demethylsterigmatocystin + S-adenosyl-L-methionine = dihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74707", "l": "Binding of IRS to insulin receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047116", "l": "1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57762", "l": "C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65201", "l": "S-(acetaldehyde)-L-cysteine => (4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55649", "l": "2-oxoglutarate + O2 + validoxylamine A => CO2 + H(+) + succinate + validoxylamine B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46850", "l": "5alpha-cholest-8-en-3-one + CO2 + NADPH => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20800", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045483", "l": "aristolochene synthase activity", "d": ["Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40581", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+) => 1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28659", "l": "beta-lactose + H2O = beta-D-galactose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692764", "l": "MAPK6 binds CCND3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.99.-", "l": "\"Other carbon-nitrogen lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78369", "l": "1-methylimidazole-4-acetaldehyde + H2O2 + NH4(+) => H2O + N(tau)-methylhistamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0015424", "l": "ABC-type amino acid transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69504", "l": "N-acetyl-D-glucosamine + O2 = H2O2 + N-acetyl-D-glucosamino-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9760402", "l": "ILF3 binds HOXC8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4086083", "l": "SUMOylation of ING2 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62620", "l": "[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O", "d": [], "t": []}, {"i": "EC:1.11.1.24", "l": "\"thioredoxin-dependent peroxiredoxin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194642", "l": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69152", "l": "Removal of remaining Flap (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63940", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(hexanoyl)sphing-4-enine + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-hexanoyl-sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58191", "l": "all-trans-lycopene + dimethylallyl diphosphate + H2O <=> dihydroisopentenyldehydrorhodopin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047503", "l": "(-)-borneol dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-borneol + NAD+ = (1S,4S)-camphor + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62797", "l": "H(+) + NADPH + O2 + 2 rubrofusarin B => aurasperone A + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658435", "l": "RAS GAPs bind RAS:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9761421", "l": "CDH11 associates with catenins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73264", "l": "genkwanin + S-adenosyl-L-methionine => apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54508", "l": "all-trans-heptaprenyl diphosphate = beta-heptaprene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16528", "l": "2-dehydro-3-deoxy-D-galactonate + ATP <=> 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51292", "l": "a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(S)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6790454", "l": "SUMOylation of XPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691154", "l": "HFE binds TFRC dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69116", "l": "Formation of Okazaki fragments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669250", "l": "PAK1 phosphorylates FLNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78603", "l": "(3S)-hydroxyoctadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203625", "l": "NOSTRIN mediated translocation of eNOS from plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62169", "l": "H2O + N,N'-diacetylchitobiose => acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69140", "l": "RPA binds to the Flap (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062148", "l": "L-gamma-glutamyl-L-propargylglycine hydroxylase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate."], "t": []}, {"i": "RHEA:59900", "l": "2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799431", "l": "TP53 binds HIPK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16033", "l": "2-oxoglutarate + gibberellin A44 + O2 = CO2 + gibberellin A19 + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.12", "l": "\"gibberellin-44 dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30030", "l": "D-glyceraldehyde + H(+) + NADH <=> glycerol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77425", "l": "(2S)-2-cyclohexyl-2-hydroxyacetonitrile => cyclohexanecarbaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38061", "l": "1-octanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879459", "l": "F-actin capping protein is a heterodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018113", "l": "lysine racemase activity", "d": ["Catalysis of the reaction: L-lysine = D-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.514861039037328", "identifiers": [{"i": "GO:0008408", "l": "3'-5' exonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end."], "t": []}, {"i": "REACT:R-HSA-3245943", "l": "Viral DNA cleavage by TREX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39435", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0016749", "l": "N-succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070463", "l": "tubulin-dependent ATPase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.6", "l": "\"dipeptidyl-dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73085", "l": "S-adenosyl-L-homocysteine + velutin => chrysoeriol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38183", "l": "19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] = 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913446", "l": "Interleukin-5 is a homodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19345", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140643", "l": "hydroxymethylglutaryl-CoA reductase (NADH) activity", "d": ["Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47851", "l": "2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69952", "l": "3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29271", "l": "a menaquinol + H(+) + trimethylamine N-oxide = a menaquinone + H2O + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052843", "l": "inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33520", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine => (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671772", "l": "p-T38-PPP1R14A binds MLCP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12927", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] => D-erythrose 4-phosphate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29585", "l": "guanosine(out) + H(+)(in) => guanosine(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264622", "l": "Cho is acetylated to AcCho by CHAT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0032555", "l": "purine ribonucleotide binding", "d": ["Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65914", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine => 3-hydroxy-L-kynurenine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35978", "l": "2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 <=> A + CO2 + H2O + succinate + verruculogen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69772", "l": "a short-chain fatty aldehyde + H2O + NAD(+) => a short-chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57649", "l": "S-adenosyl-L-methionine + trichosetin => equisetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638845", "l": "CERK phosphorylates CERA to form C1P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23758", "l": "dehydro-D-arabinono-1,4-lactone + H(+) + H2O2 => D-arabinono-1,4-lactone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41346", "l": "(5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55967", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395320", "l": "Latent TGF-beta-1 binds integrins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191072", "l": "Synthesis of Cx43 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78131", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol = a 1,3-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052726", "l": "inositol-1,3,4-trisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70549", "l": "3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53948", "l": "ATP + holo-[BtrI ACP] + L-glutamate = ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156699", "l": "Inactivation of Wee1 kinase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39902", "l": "7-deoxyloganetin + UDP-alpha-D-glucose <=> 7-deoxyloganin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177920", "l": "Binding of GRB2 to GAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047549", "l": "2-nitrophenol 2-monooxygenase activity", "d": ["Catalysis of the reaction: 2-nitrophenol + 2 H+ + 2 NADPH + O2 = catechol + H2O + 2 NADP+ + nitrite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8873929", "l": "Casein kinase II phosphorylates STARD10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58027", "l": "oleanolate + UDP-alpha-D-glucose <=> H(+) + oleanolate 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78921", "l": "a medium-chain 3-oxoacyl-CoA + H(+) + NADH => a medium-chain (3S)-3-hydroxyacyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29109", "l": "NAD(+) + ubiquinol-8 => H(+) + NADH + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69710", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O <=> beta-D-galactose + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38191", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47545", "l": "trans-4-hydroxy-L-proline betaine => cis-4-hydroxy-D-proline betaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35520", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109813", "l": "GRB2-1 binds SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75583", "l": "11-O-acetylcyathatriol + UDP-alpha-D-xylose = erinacine Q + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11875", "l": "corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805426", "l": "CARD8 binds CASP9(1-416) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77344", "l": "N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate => 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39133", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700120", "l": "PTN and MDK bind to PTPRZ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39221", "l": "(3R)-hydroxyoctacosanoyl-CoA + NADP(+) => 3-oxooctacosanyol-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21381", "l": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA => AMP + diphosphate + phytanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210836", "l": "HNF6-dependent synthesis of NEUROG3 protein during morphogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047257", "l": "diglucosyl diacylglycerol synthase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)-sn-glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78203", "l": "D-valine + H2O + O2 = 3-methyl-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11357", "l": "A + H(+) + NADH => AH2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786501", "l": "TRMT11:TRMT112 methylates guanosine-10 in tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050563", "l": "trans-feruloyl-CoA synthase activity", "d": ["Catalysis of the reaction: ATP + CoA + trans-ferulate = (E)-feruloyl-CoA + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182876", "l": "Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59698", "l": "D-cellotetraonate + H(+) => D-cellotetraono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47863", "l": "a ganglioside GT1b (d18:1(4E)) + H2O <=> a ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182990", "l": "Sprouty sequesters CBL away from active EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373706", "l": "Contactin-1 (CNTN1) binds NOTCH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65212", "l": "(2E)-dodecenoyl-CoA + H2O = (2E)-dodecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021596", "l": "Membrane estrogen receptors bind SRC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36037", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004425", "l": "indole-3-glycerol-phosphate synthase activity", "d": ["Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733545", "l": "Bile salts and acids bind ALB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37832", "l": "(S)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 => 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37908", "l": "(9Z)-octadecenoate + O2 => (8E,10S)-10-hydroperoxy-octadeca-8-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58144", "l": "acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9853499", "l": "DLD dimer dehydrogenates dihydrolipoyl (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57470", "l": "1-O-[(E)-feruloyl]-beta-D-glucose + UDP => (E)-ferulate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.10", "l": "\"ribonuclease IX\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21733", "l": "chorismate + L-glutamine => anthranilate + H(+) + L-glutamate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203567", "l": "palmitoylation of eNOS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9819200", "l": "ZFP36L2 binds CNOT6L of CCR4-CNOT complex and an AU-rich element in mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700154", "l": "Active ALK binds SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.25", "l": "\"beta-peptidyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604328", "l": "AKT1 phosphorylates NOTCH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37539", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202129", "l": "HSP90 binds eNOS:Caveolin-1:CaM complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432556", "l": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36068", "l": "Co-precorrin-6B + S-adenosyl-L-methionine => Co-precorrin-7 + CO2 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41170", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.11", "l": "\"isomaltulose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25228", "l": "L-arabinitol + NAD(+) <=> H(+) + L-arabinose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216756", "l": "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42046", "l": "a globoside Globo-H (d18:1(4E)) + GDP + H(+) => a globoside GalGb4Cer (d18:1(4E)) + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70896", "l": "N-terminal L-cysteinyl-[protein] + O2 => H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.8", "l": "\"myosin ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15623", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP => an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647978", "l": "pro-RAS proteins are farnesylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78937", "l": "a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH => a long-chain (3R)-hydroxyacyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67879", "l": "3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine <=> 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047827", "l": "D-lysopine dehydrogenase activity", "d": ["Catalysis of the reaction: D-lysopine + H2O + NADP+ = L-lysine + H+ + NADPH + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865626", "l": "p-STAT5 dimers bind the BRWD1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67659", "l": "2 Fe(III)-[cytochrome c] + NADPH <=> 2 Fe(II)-[cytochrome c] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186785", "l": "PDGF-AA clevage by Furin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48564", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66391", "l": "ATP + H2O + prostaglandin E2(in) <=> ADP + H(+) + phosphate + prostaglandin E2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399951", "l": "Phosphorylation of CRMPs by GSK3beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17931", "l": "ADP + an N-acylsphing-4-enine 1-phosphate + H(+) => an N-acylsphing-4-enine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75001", "l": "deoxyerythrostominol(out) => deoxyerythrostominol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29932", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP => ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75736", "l": "10-oxo-(12Z)-octadecenoate => 10-oxo-(11E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18676", "l": "ATP + L-seryl-[receptor-protein] <=> ADP + H(+) + O-phospho-L-seryl-[receptor-protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379977", "l": "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32938", "l": "a cardiolipin + H2O <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29105", "l": "4 H(+)(out) + menaquinol-8 + NAD(+) => 5 H(+)(in) + menaquinone-8 + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647999", "l": "RCE1 cleaves S-Farn proRAS proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24884", "l": "H(+) + L-glutamate + NADPH => (S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62844", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose = beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603419", "l": "Activated NTRK3 binds SRC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19422", "l": "(R)-2-hydroxypropyl-coenzyme M => (R)-1,2-epoxypropane + coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357472", "l": "PAK1-3 autophosphorylates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74587", "l": "(2E,6E)-farnesyl diphosphate = (+)-exo-beta-bergamotene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.211", "l": "\"(+)-exo-beta-bergamotene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649726", "l": "LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9860278", "l": "p-S446-IRF5 dimer translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683831", "l": "CCDC59 binds TTF1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800490", "l": "ATM phosphorylates PIDD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39542", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH <=> (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222353", "l": "Protonation of superoxide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603797", "l": "PEX19:PEX3 binds PEX16 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16826", "l": "ATP + uridine => ADP + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912727", "l": "CBL binds VAV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050208", "l": "polysialic-acid O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688459", "l": "RIPK3 binds HSP90:CDC37 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217152", "l": "Formation of a multi-protein complex, cohesin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34985", "l": "sulfate(out) => sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202111", "l": "AKT1 phosphorylates eNOS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10958", "l": "H2O + NADP(+) + trans-2-coumarate => (E)-cinnamate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204485", "l": "Basigin binds CyPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.-", "l": "\"Acting on carbohydrates and derivatives\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12659", "l": "a (2R)-2-methylacyl-CoA => a (2S)-2-methylacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50321", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11531", "l": "2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47778", "l": "2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34883", "l": "ATP + H2O + selenate(out) = ADP + H(+) + phosphate + selenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57247", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP <=> dGTP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60517", "l": "L-tryptophan => D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58951", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70596", "l": "GOT2 dimer deaminates L-Asp (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34508", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate => N,N-diacetyllegionaminate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016216", "l": "isopenicillin-N synthase activity", "d": ["Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9824986", "l": "XPO1-dependent export of p-S69,S73 MITF-M (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77668", "l": "a globoside GalGb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a globoside GlcNAc-GalGb4Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839388", "l": "TGFBR3 translocation to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11918", "l": "15-oxoprostaglandin E2 + H(+) + NADH => 13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749609", "l": "BCHE hydrolyzes ASA- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23100", "l": "ATP + dAMP = ADP + dADP", "d": [], "t": []}, {"i": "EC:2.7.4.11", "l": "\"(deoxy)adenylate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9718360", "l": "GNRHR binds GNRHR peptide agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62986", "l": "hexadecanoate + NH4(+) => H2O + hexadecanamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64872", "l": "D-ribulose 1-phosphate = dihydroxyacetone phosphate + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797803", "l": "PTPRD binds SLITRK1-6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0071814", "l": "protein-lipid complex binding", "d": ["Binding to a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009282", "l": "CDK1 phosphorylates RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19342", "l": "2 H(+) + O2 + octane + 2 reduced [rubredoxin] => H2O + octan-1-ol + 2 oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420274", "l": "GIP receptor binds gastric inhibitory peptide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73870", "l": "serotonin(out) <=> serotonin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18314", "l": "(R)-mandelonitrile => benzaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27313", "l": "naphthalene-1,2-diol + O2 <=> 2-hydroxychromene-2-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59527", "l": "9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein] <=> 9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015499", "l": "formate transmembrane transporter activity", "d": ["Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.5", "l": "\"flavone synthase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23162", "l": "L-rhamnulose => L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.9", "l": "\"T4 deoxyribonuclease IV\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41883", "l": "(2E)-dodecenoyl-[ACP] + H(+) + NADPH <=> dodecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50100", "l": "dodecanoyl-CoA + taurine = CoA + H(+) + N-dodecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33711", "l": "4-sulfomuconolactone + H2O = 2 H(+) + maleylacetate + sulfite", "d": [], "t": []}, {"i": "EC:3.1.1.92", "l": "\"4-sulfomuconolactone hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001082", "l": "inulin binding", "d": ["Binding to inulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34261", "l": "(+)-3'-hydroxylarreatricin + A + H2O => (+)-larreatricin + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49679", "l": "H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 <=> H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.53", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667037", "l": "RHPN2 binds RHOB:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429101", "l": "HMIT co-transports myo-inositol with a proton (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168445", "l": "PTP1B binds the GH receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659926", "l": "Defective SI does not hydrolyze Suc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731613", "l": "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21777", "l": "(25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + ATP + CoA => (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036383", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69592", "l": "CMP + inosine = cytidine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5220959", "l": "TDG excises 5-formylcytosine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102037", "l": "4-nitrotoluene monooxygenase activity", "d": ["Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 = 4-nitrobenzyl alcohol + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37484", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine => 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25422", "l": "3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate => 3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869568", "l": "NPM1 binds TFAP2A homodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57219", "l": "dGTP + glyoxal <=> N(2)-(1-hydroxy-2-oxoethyl)-dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803719", "l": "TP53 binds ZNF385A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37152", "l": "(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate => 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39395", "l": "3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20878", "l": "(E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein] => (R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48643", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) <=> 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050323", "l": "taurine dehydrogenase activity", "d": ["Catalysis of the reaction: A + H2O + taurine = AH(2) + NH4 + sulfoacetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9835454", "l": "DNAJC3 binds PKR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9612219", "l": "ERBB4s80 binds to SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75689", "l": "ATP(out) => ATP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52856", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine", "d": [], "t": []}, {"i": "EC:1.5.8.4", "l": "\"dimethylglycine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016995", "l": "cholesterol oxidase activity", "d": ["Catalysis of the reaction: cholesterol + O2 = cholest-5-en-3-one + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48547", "l": "[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine <=> [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177923", "l": "Sustained activation of SRC kinase by SHP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9612219", "l": "ERBB4s80 binds to SRC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20643", "l": "3 H(+) + L-histidine + 2 NADH => H2O + L-histidinol + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10052", "l": "(R)-2-hydroxy-4-methylpentanoate + NAD(+) = 4-methyl-2-oxopentanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635868", "l": "ub-GLI is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047401", "l": "trithionate hydrolase activity", "d": ["Catalysis of the reaction: H2O + trithionate = H+ + sulfate + thiosulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58371", "l": "(2E,6Z)-nona-2,6-dien-1-ol + NADP(+) <=> (2E,6Z)-nona-2,6-dienal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67218", "l": "(2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50830", "l": "(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate => (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13685", "l": "lathosterol + NADP(+) = 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48338", "l": "a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023983", "l": "18(R)-RvE1, E2 and E3 translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77845", "l": "2-dehydro-D-glucose + H2O2 + L-tyrosine => H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-tyrosine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30102", "l": "1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448741", "l": "IL22RA2 binds IL22 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604722", "l": "Activation of proMMP9 by proteases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66176", "l": "ATP + H2O + taurochenodeoxycholate 3-sulfate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48146", "l": "ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate => H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005360", "l": "insulin-responsive glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74480", "l": "(-)-cyclopeptine + 2-oxoglutarate + O2 => (Z)-dehydrocyclopeptine + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63792", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44321", "l": "1-decanoylglycerol + H2O => decanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786050", "l": "IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473594", "l": "Collagen type II degradation by MMP15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928624", "l": "EPHBs bind EFNBs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23172", "l": "ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] = ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63858", "l": "(2R)-2-hydroperoxytetradecanoate => O2 + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73346", "l": "beta-alanyl-5'-AMP + holo-[peptidyl-carrier protein] <=> AMP + beta-alanyl-[peptidyl-carrier protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9676257", "l": "Formation of the SET1A complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46974", "l": "AH2 + bisanhydrobacterioruberin => A + dihydrobisanhydrobacterioruberin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21205", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol => a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0008912", "l": "lactaldehyde reductase activity", "d": ["Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+."], "t": []}, {"i": "EC:1.1.1.77", "l": "\"lactaldehyde reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69326", "l": "4-methylsulfanylbutyl isothionate + H(+) + sulfate => (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016979", "l": "lipoate-protein ligase activity", "d": ["Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022851", "l": "GABA-gated chloride ion channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102983", "l": "xylogalacturonan beta-1,3-xylosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-xylose + a homogalacturonan = UDP + 4 H+ + a xylogalacturonan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442387", "l": "ZIP8 mediates zinc influx into cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52193", "l": "(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70566", "l": "H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75510", "l": "n H(+)(out) + taurocholate(out) <=> n H(+)(in) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0033744", "l": "L-methionine:thioredoxin-disulfide S-oxidoreductase activity", "d": ["Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46580", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vitamin D2 = 25-hydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187020", "l": "Part of pro-beta-NGF is processed to mature beta-NGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11767", "l": "H2O + methylguanidine <=> methylamine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69629", "l": "H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.80", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17558", "l": "anthranilate + malonyl-CoA => CoA + N-malonylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41425", "l": "2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 => formate + grixazone A + H(+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66245", "l": "ATP + H(+) + IC-asc-C9 => diphosphate + IC-asc-C9-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25537", "l": "ent-copalyl diphosphate => diphosphate + ent-sandaracopimara-8(14),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70754", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202709", "l": "JAM2 dimerises (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54287", "l": "H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-octadecanoylsphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015139", "l": "alpha-ketoglutarate transmembrane transporter activity", "d": ["Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle."], "t": []}, {"i": "REACT:R-HSA-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390674", "l": "ADRB1 bind ADR,NAd (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017797", "l": "NOTCH3 binds YBX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23827", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) <=> 2,3-dihydroxybenzoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6802973", "l": "PLK3 phosphorylates CDC25C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51692", "l": "prephenate + S-adenosyl-L-methionine = 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33661", "l": "H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+) => H(+) + N-tetracosanoylsphinganine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32878", "l": "a 1-acyl-sn-glycerol + H2O <=> a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37481", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25148", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde => H(+) + H2O + quinolinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48659", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706354", "l": "Ubiquitination of FLT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950128", "l": "Interleukin-12 dissociates from Interleukin-12 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785181", "l": "LMF1,2 bind LIPC dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68394", "l": "acetate + H(+) + H2O2 => H2O + peracetic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32837", "l": "4-(trimethylamino)butanoate(out) => 4-(trimethylamino)butanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265301", "l": "Corticotropin cleavage from POMC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052873", "l": "FMN reductase (NADPH) activity", "d": ["Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34149", "l": "2-deoxy-scyllo-inosamine + 2-oxoglutaramate => 2-deoxy-L-scyllo-inosose + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64203", "l": "an N-(fatty acyl)-L-leucine + H2O <=> a fatty acid + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49038", "l": "(-)-bursehernin + H(+) + S-adenosyl-L-homocysteine => (-)-pluviatolide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59470", "l": "an S-substituted L-cysteinylglycine + L-glutamate => an S-substituted glutathione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0035252", "l": "UDP-xylosyltransferase activity", "d": ["Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391936", "l": "EP1 receptor can bind PGE2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69419", "l": "H(+) + H2O2 + thiocyanate <=> H2O + hypothiocyanous acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38627", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43364", "l": "L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose = beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615682", "l": "Complexed PIWIL1 binds pre-piRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382056", "l": "Crk binds to the active PDGF receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050007", "l": "isonocardicin synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nocardicin E = S-methyl-5'-thioadenosine + H+ + isonocardicin A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13500", "l": "5-dehydro-2-deoxy-D-gluconate + ATP <=> 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45259", "l": "hexadecanoate(out) <=> hexadecanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877153", "l": "STARD7 binds PC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825555", "l": "RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60836", "l": "a 5'-end diphospho-adenosine in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69083", "l": "3,4-dihydroxyphenylacetaldehyde + H2O + NAD(+) <=> 3,4-dihydroxyphenylacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029473", "l": "Branching and elongation of mother and daughter filaments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1253343", "l": "WWOX binds ERBB4s80 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624951", "l": "TNPO1 binds KIF17 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69724", "l": "(indol-3-yl)acetyl-AMP + CoA => (indol-3-yl)acetyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035731", "l": "dinitrosyl-iron complex binding", "d": ["Binding to a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60764", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-cinerolone = cinerin II + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110322", "l": "Formation of Pol zeta complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051787", "l": "misfolded protein binding", "d": ["Binding to a misfolded protein."], "t": []}, {"i": "REACT:R-HSA-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726875", "l": "HCNs:cAMP bind SNIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44753", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-555065", "l": "Formation of clathrin coated vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51855", "l": "(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22951", "l": "D-tagatofuranose 1,6-bisphosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64404", "l": "carnosine(out) + H(+)(out) = carnosine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426566", "l": "Interaction of DAP12 and CLM7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374663", "l": "DCC interaction with Ezrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140483", "l": "kinetochore adaptor activity", "d": ["The binding activity of a protein that brings the kinetochore and another molecule into contact, permitting those molecules to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36212", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25396", "l": "(9Z,12Z)-octadecadienoate + O2 => (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42655", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine <=> diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669250", "l": "PAK1 phosphorylates FLNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67656", "l": "2 Fe(III)-[cytochrome c] + NADPH = 2 Fe(II)-[cytochrome c] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047027", "l": "benzyl-2-methyl-hydroxybutyrate dehydrogenase activity", "d": ["Catalysis of the reaction: benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP+ = benzyl 2-methyl-3-oxobutanoate + H+ + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905575", "l": "ganglioside GM3 binding", "d": ["Binding to ganglioside GM3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11499", "l": "O-acetyl-L-serine + uracil <=> 3-(uracil-1-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0035381", "l": "ATP-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018620", "l": "phthalate 4,5-dioxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53131", "l": "delta-carotene <=> epsilon-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683964", "l": "ATM phosphorylates EYA1-4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028598", "l": "Phosphorylation of YAP by LATS1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66437", "l": "NADP(+) + pentan-3-one => H(+) + NADPH + pent-1-en-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61579", "l": "(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) <=> (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48892", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047034", "l": "15-hydroxyicosatetraenoate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2018682", "l": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30131", "l": "H2O + octanoyl-[ACP] = H(+) + holo-[ACP] + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23966", "l": "(E)-ferulate + 2 H(+) + NADPH => (E)-coniferaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62097", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O => 2-(9Z-octadecenoyl)-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.52", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9842671", "l": "Active LTK binds IRS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78306", "l": "guanosine(34) in tRNA(Asp) + queuine <=> guanine + queuosine(34) in tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18097", "l": "pteridine-2,4,6,7-tetrol = H(+) + xanthine-8-carboxylate", "d": [], "t": []}, {"i": "EC:5.5.1.3", "l": "\"tetrahydroxypteridine cycloisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35950", "l": "dihydrochanoclavine-I aldehyde + NADP(+) <=> chanoclavine-I aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29586", "l": "guanosine(in) + H(+)(out) <=> guanosine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662606", "l": "MT3 binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784959", "l": "BPHL hydrolyses VACV to ACV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76479", "l": "hexadecane-1,16-diol + O2 = H2O2 + hydroxyhexadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67681", "l": "a long-chain fatty acyl-CoA + H2O => a long-chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961651", "l": "E2F1 binds the PCNA gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28458", "l": "biotin(in) = biotin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67762", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419644", "l": "Transphosphorylation of pLIMK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791349", "l": "Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34835", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine = a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67713", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24219", "l": "(2E,6E)-farnesal + H2O + NAD(+) <=> (2E,6E)-farnesoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2581488", "l": "SAG binds p-MII to form p-MII:SAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849878", "l": "PSD-95 binds NMDA receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006323", "l": "Phospho-JAK2 phosphorylates EPOR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928639", "l": "p-EFNB binds GRB4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050181", "l": "phorbol-diester hydrolase activity", "d": ["Catalysis of the reaction: H2O + phorbol 12,13-dibutanoate = butanoate + H+ + phorbol 13-butanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099618", "l": "UDP-glucuronic acid dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14346", "l": "H(+) + L-tyrosine => CO2 + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37758", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210309", "l": "Interaction of DAP12 and KIR2DS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10965", "l": "ATP + D-xylulose => ADP + D-xylulose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55276", "l": "9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507868", "l": "Aquaporins passively transport water into cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32724", "l": "L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.9", "l": "\"agaritine gamma-glutamyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018783", "l": "deisopropyldeethylatrazine hydrolase activity", "d": ["Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9690461", "l": "FKBP1A binds tacrolimus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202500", "l": "Activation of IKK complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45414", "l": "glycerol + H(+) + prostaglandin D2 => H2O + prostaglandin D2-1-glycerol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68361", "l": "L-xylono-1,4-lactone + O2 => dehydro-L-arabinono-1,4-lactone + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75553", "l": "AMP + an isonitrile lipopeptide + diphosphate + 2 holo-[ACP] + 2 NADP(+) => 2 a (3R)-3-isocyanyl-fatty acyl-[ACP] + ATP + L-lysine + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660980", "l": "p-S276-RELA binds RELB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31779", "l": "an all-trans-retinyl ester + H2O = 13-cis-retinol + a fatty acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.90", "l": "\"all-trans-retinyl ester 13-cis isomerohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50034", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine => H2O + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35231", "l": "rifampicin(in) = rifampicin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19937", "l": "glycine + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sarcosine", "d": [], "t": []}, {"i": "EC:2.1.1.20", "l": "\"glycine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632738", "l": "DDIT4 binds 14-3-3 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769000", "l": "NOTCH1 PEST domain mutants bind DLL4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11629", "l": "a 2-oxocarboxylate + H(+) => an aldehyde + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9822532", "l": "ADAMTS13 cleaves VWF multimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35235", "l": "H(+)(out) + tetracycline(in) = H(+)(in) + tetracycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55707", "l": "glycine + hydrogen sulfide + NAD(+) <=> ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804762", "l": "TP53 forms homotetramers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9711016", "l": "SARS-CoV-1 nsp3 deubiquinates K63-linked pUb-STING (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023461", "l": "MECP2 T158A:SIN3A complex does not bind BDNF gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27798", "l": "(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = all-trans-octaprenyl diphosphate + 5 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.90", "l": "\"all-trans-octaprenyl-diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15136", "l": "H2O + L-glutamate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57035", "l": "(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O <=> CO2 + formate + methylamine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203700", "l": "eNOS translocation from Golgi to Caveolae (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41532", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine", "d": [], "t": []}, {"i": "EC:1.14.16.7", "l": "\"phenylalanine 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.3", "l": "\"gastricsin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31220", "l": "5-hydroxykynurenamine + CO2 => 5-hydroxy-L-kynurenine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53375", "l": "5,6-dihydrouridine(17) in tRNA + NAD(+) <=> H(+) + NADH + uridine(17) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46212", "l": "H2O + N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine = 4-amino-5-aminomethyl-2-methylpyrimidine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607722", "l": "Active NIK phosphorylates IKKA dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445072", "l": "Interaction of PAK1 with Rac1-GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10103", "l": "a sterol ester + H2O <=> a fatty acid + a sterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17833", "l": "3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.97", "l": "\"3-hydroxyanthranilate 4-C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30349", "l": "ADP + ITP => ATP + IDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936960", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444523", "l": "CXCR5 binds CXCL13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45715", "l": "3-dehydrocarnityl-CoA + CoA <=> acetyl-CoA + N,N,N-trimethylglycyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801776", "l": "REG3A binds bacterial phospholipids (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78973", "l": "CO2 + isopentenyl phosphate => (2E)-3-methyl-5-phosphooxypent-2-enoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49883", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71682", "l": "H(+)(out) + L-lysyl-glycine(out) <=> H(+)(in) + L-lysyl-glycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21223", "l": "L-dopa + O2 <=> 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68869", "l": "ATP + benzoate + H(+) + NADPH => AMP + benzaldehyde + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69572", "l": "dIMP + inosine = 2'-deoxyinosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34351", "l": "(2E)-geranial + H2O + NAD(+) = geranate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.86", "l": "\"geranial dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050014", "l": "ketotetrose-phosphate aldolase activity", "d": ["Catalysis of the reaction: L-erythrulose 1-phosphate = formaldehyde + glycerone phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018826", "l": "RHOT2 hydrolyzes GTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18961", "l": "D-allose + L-lysyl-[protein] = H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31795", "l": "(+)-(E)-beta-caryophyllene + H2O = (+)-caryolan-1-ol", "d": [], "t": []}, {"i": "EC:4.2.1.138", "l": "\"(+)-caryolan-1-ol synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047276", "l": "N-acetyllactosaminide 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389381", "l": "Gads binds CD28 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21361", "l": "ATP + beta-nicotinamide D-ribonucleotide + H(+) => diphosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78256", "l": "D-ornithine + H2O + O2 => 5-amino-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11870", "l": "D-ribulose + H(+) + NADPH => D-arabinitol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000007", "l": "low-affinity zinc ion transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24518", "l": "CoA + H(+) + N(2')-acetylgentamicin C1a => acetyl-CoA + gentamicin C1a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69074", "l": "Formation of Processive Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29260", "l": "(2R,3R)-tartrate(out) + succinate(in) => (2R,3R)-tartrate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47241", "l": "H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18367", "l": "CO2 + NADH + pyruvate => (R)-malate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9675026", "l": "Formation of the MLL1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15048", "l": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) <=> H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66318", "l": "alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+) => an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36298", "l": "alpha-maltose 6'-phosphate + H2O <=> D-maltose + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11482", "l": "3,4-dihydroxybenzoate + H2O + NADP(+) => 3-hydroxybenzoate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70221", "l": "20beta-dihydrocorticosterone + NADP(+) => corticosterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27742", "l": "2'-deoxyadenosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73847", "l": "17alpha-hydroxywithaferin A + UDP-alpha-D-glucose = 17alpha-sitoindoside IX + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29423", "l": "ATP + diphosphate = ADP + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14797", "l": "2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2423785", "l": "CR:atREs binds apoE and HSPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34468", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + valerena-4,7(11)-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938231", "l": "RUNX1:CBFB binds CREBBP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46257", "l": "a (7Z,10Z,13Z,16Z)-docosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9861642", "l": "NEK1 phosphorylates ME1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47921", "l": "ganglioside GM2 (d18:1(4E)/18:0) + H2O => ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375138", "l": "CDO binds BOC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38506", "l": "a 1,3-diacyl-sn-glycerol + H2O <=> a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781899", "l": "USP13 binds SIAH2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10987", "l": "(S)-lactate + oxaloacetate <=> (S)-malate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646685", "l": "Aggresome dissociates from dynein and microtubule (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40377", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23821", "l": "GDP-alpha-D-mannose => GDP-4-dehydro-alpha-D-rhamnose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68085", "l": "GTP + L-histidyl-[RNA ligase] => diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70487", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2 = a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75224", "l": "H2O + L-fucono-1,4-lactone => H(+) + L-fuconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031782", "l": "type 4 melanocortin receptor binding", "d": ["Binding to a type 4 melanocortin receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21883", "l": "2 H(+) + O2 + oxalate <=> 2 CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693347", "l": "CRYM reduces P2C to PPCA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45035", "l": "4 Fe(III)-[cytochrome c] + H2O + hydroxylamine <=> 4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11858", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+) => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047307", "l": "diaminobutyrate-pyruvate transaminase activity", "d": ["Catalysis of the reaction: L-2,4-diaminobutyrate + pyruvate = L-alanine + L-aspartate 4-semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2564826", "l": "4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9824999", "l": "GSK3B phosphorylates p-S73 MITF-M at residue S69 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45114", "l": "13-hydroxy-gamma-tocopherol + H2O + NADP(+) => gamma-tocopherol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16838", "l": "5'-acylphosphoadenosine + H2O => a carboxylate + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170149", "l": "Translocation of active Cdc25C to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168376", "l": "STIM1 oligomerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052752", "l": "reduced coenzyme F420:heterodisulfide oxidoreductase activity", "d": ["Catalysis of the reaction: reduced coenzyme F420 + CoB-S-S-CoM = coenzyme F420 + CoM-SH + CoB-SH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44768", "l": "3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) = 2-methoxy-6-(all-trans-hexaprenyl)phenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13347", "l": "diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] => (2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854462", "l": "VLDLR binds VLDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687107", "l": "MAPK4,6 translocate to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78874", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NAD(+) <=> a very-long-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47103", "l": "choloyl-CoA + taurine <=> CoA + H(+) + taurocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015538", "l": "sialic acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75622", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate <=> ectocarpin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211219", "l": "Translocation of caspase-3 to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9838093", "l": "LONP1 binds mitochondrial matrix proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139842", "l": "Binding of Syk tyrosine kinase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71845", "l": "tauroursodeoxycholate(in) => tauroursodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70720", "l": "L-alanine(in) => L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34073", "l": "N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP => trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47703", "l": "H(+) + ketocytochalasin + NADPH + O2 <=> H2O + iso-precytochalasin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10587", "l": "4-coumaroyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 3 CO2 + 4 CoA + H2O + isoliquiritigenin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47151", "l": "a ubiquinone + caffeine + H2O <=> 1,3,7-trimethylurate + a ubiquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43745", "l": "ATP + cytidine(34) in tRNA(Ile2) + L-lysine => AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621356", "l": "PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62591", "l": "2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) <=> 4-hydroxybenzyl alcohol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047651", "l": "alkylhalidase activity", "d": ["Catalysis of the reaction: bromochloromethane + H2O = bromide + chloride + formaldehyde + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10808", "l": "(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-epoxypropylphosphonate + 2 H2O", "d": [], "t": []}, {"i": "EC:1.11.1.23", "l": "\"(S)-2-hydroxypropylphosphonic acid epoxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62294", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2 => (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67551", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O <=> [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75244", "l": "FASL binds FAS Receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167181", "l": "Addition of nucleotides leads to HIV-1 transcript elongation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090555", "l": "phosphatidylethanolamine flippase activity", "d": ["Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}, {"i": "RHEA:66132", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009815", "l": "1-aminocyclopropane-1-carboxylate oxidase activity", "d": ["Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = CO2 + dehydroascorbate + ethylene + 2 H2O + hydrogen cyanide. Ethene is also known as ethylene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700149", "l": "Active ALK binds PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043838", "l": "phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity", "d": ["Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26378", "l": "GTP => cyclic pyranopterin phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420883", "l": "Opsins act as GEFs for G alpha-t (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70461", "l": "a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445071", "l": "Reinsertion of L1 into the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26523", "l": "(2S,3S)-2-methylcitrate => 2-methyl-trans-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0017070", "l": "U6 snRNA binding", "d": ["Binding to a U6 small nuclear RNA (U6 snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710354", "l": "GSDME (1-270) binds cardiolipin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54345", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27361", "l": "chloride + S-adenosyl-L-methionine = chloromethane + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660822", "l": "ATP binds P2RX4,7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46664", "l": "corticosterone + H(+) + NADPH = 5beta-dihydrocorticosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0047801", "l": "L-cysteine transaminase activity", "d": ["Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14928", "l": "D-mannitol 1-phosphate + NADP(+) <=> D-mannose 6-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74664", "l": "acetylcholine(in) => acetylcholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.752469279128519", "identifiers": [{"i": "GO:0016893", "l": "endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters."], "t": []}, {"i": "EC:3.1.30.-", "l": "\"Endoribonucleases active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74479", "l": "(-)-cyclopeptine + 2-oxoglutarate + O2 = (Z)-dehydrocyclopeptine + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67292", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41075", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50038", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine => choloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55364", "l": "(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 6 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30362", "l": "chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2 <=> chlorophyllide b + 3 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50651", "l": "2-(2-methylsulfanyl)ethylmalate <=> 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61046", "l": "(-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855188", "l": "IP6 transports from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983153", "l": "E1 mediated ubiquitin activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25535", "l": "ent-copalyl diphosphate <=> diphosphate + ent-cassa-12,15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849094", "l": "ARHGAP35 binds RASA1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211950", "l": "CYP24A1 24-hydroxylates CTL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035956", "l": "Defective CYP17A1 does not cleave 17aHPROG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26470", "l": "(E)-feruloyl-CoA + 16-hydroxyhexadecanoate = 16-feruloyloxyhexadecanoate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.188", "l": "\"omega-hydroxypalmitate O-feruloyl transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748991", "l": "XDH oxidises 6MP to 6TU (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004516", "l": "nicotinate phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H+ + nicotinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202241", "l": "Recruitment of SLP-76 to Gads (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51036", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 = 2 H2O + indole-3-pyruvate imine dimer", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70730", "l": "3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O <=> 6-sulfo-alpha-D-quinovose + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59235", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> diphosphate + hydropyrenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454699", "l": "AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77527", "l": "hexanal + hydrogen cyanide = (2S)-2-hydroxyheptanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955706", "l": "TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192042", "l": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28556", "l": "D-mannose + phosphate => D-mannose 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63976", "l": "A + dihydropyriculariol = AH2 + pyriculariol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046028", "l": "electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity", "d": ["Enables the directed movement of electrons from the cytochrome b6/f complex of photosystem II."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473184", "l": "Follistatin (FST) binds Activin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42963", "l": "H(+) + NAD(+) + 2 reduced [nitric oxide reductase rubredoxin domain] <=> NADH + 2 oxidized [nitric oxide reductase rubredoxin domain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218806", "l": "FYN autophosphorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15179", "l": "a fatty acid + H(+) + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29110", "l": "H(+) + NADH + ubiquinone-8 <=> NAD(+) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74986", "l": "Elongation of pre-rRNA transcript (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72707", "l": "GDP-beta-L-fucose(in) + GMP(out) = GDP-beta-L-fucose(out) + GMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19514", "l": "carbamoyl phosphate + L-ornithine => H(+) + L-citrulline + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698924", "l": "B Nucleocapsid Assembly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835009", "l": "PRKN binds p-S-Ub:MOM proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010179", "l": "IAA-Ala conjugate hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetyl-alanine + H2O = indole-3-acetate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37045", "l": "ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate => ATP + H2O + L-alanyl-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840401", "l": "DELE1(143-515) is released into the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004411", "l": "homogentisate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33732", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672980", "l": "Dissociation of RAS:RAF complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64159", "l": "an N-(fatty acyl)-L-methionine + H2O <=> a fatty acid + L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50136", "l": "ethyl (9Z)-octadecenoate + H2O = (9Z)-octadecenoate + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022396", "l": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-43) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60391", "l": "Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O <=> Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50574", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30998", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoradiol <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + soyasapogenol B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59220", "l": "(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.25", "l": "\"2-hydroxy-6-oxohepta-2,4-dienoate hydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62768", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-5alpha-cholest-7-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354097", "l": "Activation of Talin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36810", "l": "H(+) + malonyl-CoA + octacosanoyl-CoA <=> 3-oxo-triacontanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047914", "l": "gamma-glutamylhistamine synthase activity", "d": ["Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806974", "l": "MET dimers autophosphorylate (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944262", "l": "Association of procollagen type X (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18721", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = diphosphate + ent-13-epi-manoyl oxide", "d": [], "t": []}, {"i": "EC:4.2.3.186", "l": "\"ent-13-epi-manoyl oxide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74187", "l": "S-adenosyl-L-methionine + taxifolin = H(+) + S-adenosyl-L-homocysteine + taxifolin 3'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814096", "l": "ARL1:GTP binds SCOC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102305", "l": "(13E)-labda-7,13-dien-15-ol synthase activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29798", "l": "ATP(in) + H2O(in) + Zn(2+)(out) <=> ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50509", "l": "acetyl-CoA + N-terminal L-valyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38792", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204600", "l": "Basigin homodimerises (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27920", "l": "2 H(+) + NADPH + propanoate => H2O + NADP(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56888", "l": "UDP-4-dehydro-6-deoxy-alpha-D-glucose = UDP-4-dehydro-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858270", "l": "HILPDA binds lipid droplets (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61530", "l": "a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50686", "l": "aniline + H(+) + L-glutamate => H2O + N(5)-phenyl-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75912", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57330", "l": "CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein] => acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29537", "l": "a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204485", "l": "Basigin binds CyPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74381", "l": "2 (S)-lactate(out) + prostaglandin H2(in) => 2 (S)-lactate(in) + prostaglandin H2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68822", "l": "(6E)-nerolidol + diphosphate => (2Z,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797100", "l": "CCNK binds CDK13 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39862", "l": "a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol <=> a triacyl-sn-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34294", "l": "2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose <=> 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.42", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835011", "l": "PINK1 phosphorylates PRKN at S65 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964274", "l": "G alpha (12) binds BTK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59980", "l": "8-oxo-dGTP + H2O = 8-oxo-dGDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0004457", "l": "lactate dehydrogenase activity", "d": ["Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332363", "l": "Autophosphorylation and activation of CAMK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9815501", "l": "MAPKAPK2 phosphorylates RIPK1 at S320 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-933533", "l": "Dimerization of p-IRF7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009383", "l": "rRNA (cytosine-C5-)-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050335", "l": "thiocyanate isomerase activity", "d": ["Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31443", "l": "ATP + D-sedoheptulose 7-phosphate = ADP + D-sedoheptulose 1,7-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76849", "l": "butan-2-one + H(+) + NADH + NH4(+) => (R)-sec-butylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200406", "l": "CPT1A,B transfers PALM to CAR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240787", "l": "E2F1/2/3 stimulates SUZ12 transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9839401", "l": "TGFBR3 degradation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696822", "l": "AKR1B15 reduces EST17b to E1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11068", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.107", "l": "\"protein-glucosylgalactosylhydroxylysine glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64120", "l": "an N-(fatty acyl)-L-serine + H2O = a fatty acid + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651789", "l": "LIG1 bound to POLB ligates SSB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44358", "l": "methyl nogalonate => nogalaviketone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77163", "l": "H(+) + hercynine + N-acetyl-1-seleno-beta-D-glucosamine + O2 = H2O + hercynyl-SeGlcNAc selenoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44708", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54269", "l": "2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 => (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63090", "l": "a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine => a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54763", "l": "ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide <=> 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627089", "l": "CASP9 is phosphorylated at T412 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159796", "l": "Furin cleaves pro-factor IX to factor IX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862184", "l": "USP48 cleaves polyubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18364", "l": "a dolichyl D-xylosyl phosphate + L-seryl-[protein] <=> 3-O-(beta-D-xylosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49563", "l": "D-sedoheptulose 7-phosphate <=> (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72545", "l": "2-oxoglutarate(out) + dehydroepiandrosterone 3-sulfate(in) => 2-oxoglutarate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047213", "l": "anthocyanidin 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043811", "l": "phosphate:acyl-[acyl carrier protein] acyltransferase activity", "d": ["Catalysis of the reaction: a fatty acyl-[acyl-carrier protein] + orthophosphate = acyl phosphate + [acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-996755", "l": "ZFPM proteins bind GATA proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60576", "l": "coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] = Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}, {"i": "EC:2.1.1.253", "l": "\"[methyl-Co(III) tetramethylammonium-specific corrinoid protein]:coenzyme M methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005523", "l": "tropomyosin binding", "d": ["Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140306", "l": "lipoprotein releasing activity", "d": ["The activity of recognizing mature outer membrane lipoproteins in the inner membrane and releasing from the inner membrane so that they can be transported across the periplasmic space to their target location, the outer membrane. This function exists in diderm bacteria, mediated by the LolCDE complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030549", "l": "acetylcholine receptor activator activity", "d": ["Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033940", "l": "glucuronoarabinoxylan endo-1,4-beta-xylanase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-xylosyl links in some glucuronoarabinoxylans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54048", "l": "(2E,6E)-farnesyl diphosphate + H2O = 4-epi-cubebol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.170", "l": "\"4-epi-cubebol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42398", "l": "2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine => cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097162", "l": "MADS box domain binding", "d": ["Binding to a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30596", "l": "4-hydroxyphenylacetate + FADH2 + O2 => 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781922", "l": "USP13 binds UFD1L:SKP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10868", "l": "a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.20", "l": "\"diacylglycerol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49076", "l": "dibenzothiophene + FMNH2 + O2 = dibenzothiophene 5-oxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44085", "l": "ATP + CoA + heptadecanoate => AMP + diphosphate + heptadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830805", "l": "Nascent sG localizes to ER lumen, gets glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11514", "l": "H(+) + salicin + UDP => salicyl alcohol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13466", "l": "(S)-2,3-diaminopropanoate + oxalyl-CoA => CoA + N(3)-oxalyl-L-2,3-diaminopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44292", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419389", "l": "LPA-binding receptors bind LPA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50627", "l": "acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O <=> a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48693", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60694", "l": "(E)-non-2-enoate + 2 H(+) + NADPH => (E)-non-2-enal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52177", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222431", "l": "Peroxynitrite is reduced to nitrite by AhpC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-844447", "l": "NLRP1 senses MDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56582", "l": "6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine => 6-thioguanine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51687", "l": "(2E,6E)-farnesyl phosphate + CTP <=> (2E,6E)-farnesyl diphosphate + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706308", "l": "Active FLT3 binds to GRB10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10583", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11765", "l": "H2O + methylguanidine => methylamine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047414", "l": "2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity", "d": ["Catalysis of the reaction: (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H2O + H+ = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844549", "l": "UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16193", "l": "an (R)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798474", "l": "S100A8:S100A9 binds Zn2+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647994", "l": "RAS proteins are depalmitoylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10306", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP] => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62324", "l": "(+)-malbrancheamide B + chloride + FAD + 2 H(+) = (+)-malbrancheamide + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033485", "l": "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933446", "l": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450550", "l": "PKCalpha phosphorylates HuR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34947", "l": "(Z)-3-aminoacrylate + H(+) + H2O = 3-oxopropanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429036", "l": "SLC2A9 transports Fru, Glc, urate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15180", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O <=> a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047171", "l": "glucarolactone O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44364", "l": "2-epi-5-epi-valiolone + ATP = 2-epi-5-epi-valiolone 7-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.188", "l": "\"2-epi-5-epi-valiolone 7-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15113", "l": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44851", "l": "(9Z)-tetradecenoyl-CoA + (R)-carnitine <=> CoA + O-(9Z)-tetradecenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784648", "l": "CREB3L3 (1-?) translocates from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109862", "l": "MAP2K2 phosphorylates MAPK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102841", "l": "1-18:1-2-16:2-monogalactosyldiacylglycerol synthase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047130", "l": "saccharopine dehydrogenase (NADP+, L-lysine-forming) activity", "d": ["Catalysis of the reaction: L-saccharopine + H2O + NADP+ = 2-oxoglutarate + L-lysine + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74669", "l": "(2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H(+) + H2O => (6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70876", "l": "L-glutamine(in) + L-methionine(out) + Na(+)(out) => L-glutamine(out) + L-methionine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507870", "l": "Aquaporins passively transport water out of cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730847", "l": "Hydrolysis of PIP2 by PLCG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25906", "l": "dehypoxanthine futalosine + hypoxanthine => futalosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679028", "l": "JAK3 binds JAK3 inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790022", "l": "Expression of STAT3-upregulated plasma membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004709", "l": "MAP kinase kinase kinase activity", "d": ["Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17212", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O <=> 2-formylglutarate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24708", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose => (6R)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30773", "l": "D-ribose + guanine => guanosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358790", "l": "RNF41 ubiquitinates ERBB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.115", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25496", "l": "(2E)-geranyl diphosphate = (1S,5S)-beta-pinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.120", "l": "\"(-)-beta-pinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10699", "l": "a long-chain fatty acid + ATP + holo-[mycocerosate synthase] <=> AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035484", "l": "CysS248-MPST:TXN2 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19517", "l": "H2O + N,N-dimethylformamide = dimethylamine + formate", "d": [], "t": []}, {"i": "EC:3.5.1.56", "l": "\"N,N-dimethylformamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56771", "l": "2 AH2 + all-trans-zeaxanthin + 2 O2 <=> 2 A + all-trans-adonixanthin + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851972", "l": "PLK1 phosphorylates FIRRM at S43 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75488", "l": "dehydroepiandrosterone 3-sulfate(out) + n H(+)(out) => dehydroepiandrosterone 3-sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77415", "l": "(2E)-but-2-enal + hydrogen cyanide = (2S,3E)-2-hydroxypent-3-enenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47861", "l": "a ganglioside GT1b (d18:1(4E)) + H2O => a ganglioside GD1b (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23627", "l": "a 5,6-dihydrouridine in tRNA + NADP(+) <=> a uridine in tRNA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45876", "l": "2-methylhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 6-(hexadecan-2-yl)-4-hydroxy-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805399", "l": "TAF1 phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59876", "l": "(indol-3-yl)butanoate + ATP + L-cysteine = (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22390", "l": "CoA + N(6)-acetyl-N(6)-hydroxy-L-lysine => acetyl-CoA + N(6)-hydroxy-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71647", "l": "a medium-chain (3S)-3-hydroxyacyl-CoA = a medium-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.74", "l": "\"medium-chain-enoyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654425", "l": "Activated FGFR4 binds SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76196", "l": "UDP-alpha-D-glucose(in) => UDP-alpha-D-glucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52346", "l": "(24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+) => (24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31890", "l": "(S)-2,3-epoxysqualene <=> tirucalladienol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62846", "l": "beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389463", "l": "Proteinase-activated receptors can bind thrombin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047454", "l": "phaseollidin hydratase activity", "d": ["Catalysis of the reaction: phaseollidin hydrate = H2O + phaseollidin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689000", "l": "AADAC deacetylates PHEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38132", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z-octadecadienoyl)-glycerol => 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61952", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33952", "l": "ribostamycin + UDP-N-acetyl-alpha-D-glucosamine => 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2197690", "l": "Detachment of WASP/WAVE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59336", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + A = AH2 + demethylspheroidene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825794", "l": "p-S742 TBX3 binds CDH1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061786", "l": "peptidoglycan stem peptide endopeptidase activity", "d": ["A peptidoglycan endopeptidase activity that acts on a stem peptide of peptidoglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54592", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047575", "l": "4-carboxymuconolactone decarboxylase activity", "d": ["Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H+ = 5-oxo-4,5-dihydro-2-furylacetate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67555", "l": "3'-phosphoadenylyl sulfate + cholate <=> adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.227", "l": "\"undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432483", "l": "SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61215", "l": "myricetin + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947499", "l": "Exchange of oxygen with sulfur in MoCo (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14947", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0015930", "l": "glutamate synthase activity", "d": ["Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030586", "l": "[methionine synthase] reductase activity", "d": ["Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0004661", "l": "protein geranylgeranyltransferase activity", "d": ["Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein."], "t": []}, {"i": "RHEA:21240", "l": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35696", "l": "(3S)-versiconol acetate + NADP(+) => (2S,3S)-versiconal hemiacetal acetate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46242", "l": "a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49843", "l": "(-)-dehydrodiconiferyl acid + 2 a quinone + H2O <=> (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36580", "l": "dTDP-alpha-D-fucose + NAD(+) => dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833671", "l": "CDH11 forms heterotypic trans dimer with CDH24 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52591", "l": "choloyl-CoA + NAD(+) <=> 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031727", "l": "CCR2 chemokine receptor binding", "d": ["Binding to a CCR2 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59972", "l": "decanoyl-CoA + L-seryl-[protein] = CoA + O-decanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29042", "l": "ATP + H2O + L-aspartate(out) <=> ADP + H(+) + L-aspartate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002114", "l": "interleukin-33 receptor activity", "d": ["Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005011", "l": "macrophage colony-stimulating factor receptor activity", "d": ["Combining with macrophage colony-stimulating factor (M-CSF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977375", "l": "CR1 binds C3bBb/C4bC2a (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29172", "l": "a ubiquinol + 2 O2 => a ubiquinone + 2 H(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162186", "l": "COQ3 methylates DeMQ10H2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6794347", "l": "Homer1,2,3 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32479", "l": "2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH", "d": [], "t": []}, {"i": "EC:1.21.1.1", "l": "\"iodotyrosine deiodinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39941", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+) => 1,3-di-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350058", "l": "Formation of CSL NCOR corepressor complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78595", "l": "(3R)-hydroxyeicosanoyl-CoA + NAD(+) = 3-oxoeicosanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010276", "l": "phytol kinase activity", "d": ["Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660980", "l": "p-S276-RELA binds RELB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47598", "l": "an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP => an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24331", "l": "7,8-dihydrofolate + ATP + formate <=> 10-formyldihydrofolate + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391934", "l": "DP2 receptor can bind PGD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53270", "l": "L-xylulose => L-ribulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54637", "l": "(13E)-labda-7,13-dien-15-yl diphosphate => diphosphate + labda-7,13(16),14-triene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950778", "l": "p-Y693-STAT4 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55246", "l": "4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453863", "l": "STRA6 transports atROL from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-517444", "l": "TAT aminates HPP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10466", "l": "n acetate + chitosan => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48031", "l": "H2O + triacetin <=> acetate + diacetylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77613", "l": "3-tetradecanoyl-sn-glycero-1-phospho-(3'-tetradecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol) => 2 3-tetradecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433940", "l": "Association of LBP with bacterial LPS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78328", "l": "D-erythrose 4-phosphate + L-erythrulose => beta-D-fructose 6-phosphate + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204871", "l": "Interaction of Tie2 and Grb2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.354970481220079", "identifiers": [{"i": "GO:0016812", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides", "d": ["Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390663", "l": "ADRA2A,B,C bind ADR,NAd (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34057", "l": "6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH => festuclavine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65877", "l": "5alpha-androst-1-ene-3,17-dione + H2O => 1-hydroxy-5alpha-androstan-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202960", "l": "Caspase mediated cleavage of C-IAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687625", "l": "ATP binds MLKL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011543", "l": "DCA binds PDK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976726", "l": "NOTCH2 coactivator complex binds HES5 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36744", "l": "heptadecasphing-4-enine + tetracosenoyl-CoA => CoA + H(+) + N-tetracosenoyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47673", "l": "H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) => 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20757", "l": "(E)-caffeoyl-CoA + D-threo-isocitrate => 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33344", "l": "glycine + O2 => 2-iminoacetate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51694", "l": "3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O => prephenate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019983", "l": "interleukin-9 binding", "d": ["Binding to interleukin-9."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10361", "l": "3,4-dihydrocoumarin + H2O => 3-(2-hydroxyphenyl)propanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9621179", "l": "Cinaciguat binds sGC:NO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34254", "l": "1-deoxysphinganine + NADP(+) <=> 1-deoxy-3-dehydrosphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67050", "l": "A + asnovolin I + H2O => AH2 + chermesin D + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54892", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35962", "l": "H(+) + NADPH + O2 + tryprostatin B <=> demethoxyfumitremorgin C + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38142", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809707", "l": "MTMR12 binds MTMR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17231", "l": "an acetyl ester + CoA => acetyl-CoA + an aliphatic alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799761", "l": "TP53 binds PPP1R13L (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668605", "l": "RAC2:GTP binds NOX2 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47875", "l": "a ganglioside GM1 + H2O <=> a ganglioside GA1 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727188", "l": "ATP4A:ATP4B binds PPIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48738", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042896", "l": "chloramphenicol transmembrane transporter activity", "d": ["Enables the transfer of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43839", "l": "cholesterol + H(+) + NADPH + O2 <=> 26-hydroxycholesterol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44681", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54149", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene => 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61569", "l": "an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36596", "l": "hydrogen sulfide + NADP(+) => NADPH + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67476", "l": "dimethylallyl diphosphate + L-glutamate = diphosphate + prekainate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77669", "l": "a globoside GlcNAc-GalGb4Cer (d18:1(4E)) + H(+) + UDP => a globoside GalGb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27805", "l": "(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate <=> all-trans-decaprenyl diphosphate + 7 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187211", "l": "Splicing of HIV RNA transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975633", "l": "atROL binds to RBP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0046941", "l": "azetidine-2-carboxylic acid acetyltransferase activity", "d": ["Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68929", "l": "ATP + H(+) + heptanoate + NADPH => AMP + diphosphate + heptanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50799", "l": "glutathione + prostaglandin A2 <=> prostaglandin A2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18112", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712088", "l": "ALK fusion proteins bind IRS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77077", "l": "Capping complex formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13786", "l": "(3S)-citramalyl-CoA => H2O + itaconyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.37", "l": "\"acyl-CoA 5-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419861", "l": "Melanospin is stimulated by light (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39699", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA = (2E,13Z)-eicosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43370", "l": "4-hydroxy-6-(2-oxotridecyl)pyran-2-one + 3 CO2 + 4 CoA => dodecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57856", "l": "(E)-feruloyl-CoA + 2-oxoglutarate + O2 = (E)-6-hydroxyferuloyl-CoA + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.61", "l": "\"feruloyl-CoA 6-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033429", "l": "CGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CGU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43895", "l": "[sulfur carrier]-H + L-cysteine <=> [sulfur carrier]-SH + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44289", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + CDP-choline => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64547", "l": "acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0001595", "l": "angiotensin receptor activity", "d": ["Combining with angiotensin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36930", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74975", "l": "a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP] = a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110244", "l": "Excision of FapyG by OGG1 glycosylase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70405", "l": "CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine => (9Z)-hexadecenoyl-CoA + 3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668902", "l": "Formation of the CTF18-RFC(7s) complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76389", "l": "1-L-glutamo-2-N(6-)L-lysinohydrazine + AMP + diphosphate + 2 H(+) => ATP + L-glutamate + N(6)-hydroxy-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046481", "l": "digalactosyldiacylglycerol synthase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + UDP-D-galactose = 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-glycerol + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4332236", "l": "CBL neddylates TGFBR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30365", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate => fumonisin B1 + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102823", "l": "kaempferol-3-rhamnoside-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol-3-rhamnoside = kaempferol 3-O-rhamnoside-7-O-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63010", "l": "(6Z)-octadecenoate + NH4(+) => (6Z)-octadecenamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57725", "l": "H(+) + 2 Na(+)(in) + oxaloacetate => CO2 + 2 Na(+)(out) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672164", "l": "GRB2:SOS1 complex binds to mutant PDGFR receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30726", "l": "A + 2 ADP + H(+) + NH4(+) + 2 phosphate <=> AH2 + 2 ATP + H2O + hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0160173", "l": "histamine transmembrane transporter activity", "d": ["Enables the transfer of histamine from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72799", "l": "L-arginine(out) + L-homoarginine(in) = L-arginine(in) + L-homoarginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18589", "l": "[glutamine synthetase]-L-tyrosine + ATP = [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.42", "l": "\"[glutamine synthetase] adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21877", "l": "(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) => (S)-usnate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18121", "l": "an S-substituted L-cysteine + H2O = a thiol + NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:4.4.1.13", "l": "\"cysteine-S-conjugate beta-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0016827", "l": "hydrolase activity, acting on acid carbon-phosphorus bonds", "d": ["Catalysis of the hydrolysis of any acid carbon-phosphorus bond."], "t": []}, {"i": "EC:3.11.-.-", "l": "\"Acting on carbon-phosphorus bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14985", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}, {"i": "EC:1.13.11.40", "l": "\"arachidonate 8-lipoxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022396", "l": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-43) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805640", "l": "AKT phosphorylates KAT6A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9704248", "l": "CHRM4 binds CHRM4 antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682769", "l": "LGI2 binds ADAM22,23 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51040", "l": "indole-3-pyruvate imine dimer = chromopyrrolate + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.129", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14976", "l": "L-aspartate <=> D-aspartate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32726", "l": "L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27493", "l": "S-adenosyl-L-methionine + tricetin = 3'-O-methyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180020", "l": "membrane bending activity", "d": ["The activity of bending or deforming a membrane. This activity can occur by multiple mechanisms including the insertion amphipathic domains into one or both leaflets."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112514", "l": "JAK activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72621", "l": "Ribosomal scanning  (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77300", "l": "a ubiquinone + H2O + theobromine => 3,7-dimethylurate + a ubiquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29548", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine => 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16321", "l": "(S)-indan-1-ol + NADP(+) = H(+) + indan-1-one + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43307", "l": "3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer <=> 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76168", "l": "glycyl-L-leucine(out) + 2 H(+)(out) => glycyl-L-leucine + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450088", "l": "GLUT1 tetramer binds 4xATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36837", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9859172", "l": "DLD dimer dehydrogenates dihydrolipoyl (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.375", "l": "\"L-2-hydroxycarboxylate dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656211", "l": "MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29831", "l": "Ni(2+)(in) = Ni(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78574", "l": "docosanoyl-CoA + O2 <=> (2E)-docosenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12655", "l": "CO2 + NADH + pyruvate => (S)-malate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749215", "l": "MCM8 binds CDC6 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39939", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41293", "l": "dodecanoate + sphing-4-enine => H2O + N-dodecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9859163", "l": "DBT transfers BCAA to CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60228", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41460", "l": "1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine = a 1,2-diacylglycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32930", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74288", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA => an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30888", "l": "4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin => 7,8-dihydropteroate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64541", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199558", "l": "KIR2DL1 interacting with HLA-C group 2 (Cw3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749253", "l": "Formation of MCM2-7 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33578", "l": "an inositol-1-phosphophytoceramide + beta-D-mannose <=> a mannosylinositol-1-phosphophytoceramide + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53081", "l": "4-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate => 4-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388503", "l": "Oxytocin receptor bind oxytocin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42877", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444476", "l": "FPRL2 receptor binds a wide range of ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534365", "l": "Slo3 Potassium Transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759158", "l": "SQSTM1 oligomerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814153", "l": "ADO oxidises 2AET to HTAU (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38605", "l": "2'-phospho-cyclic ADP-ribose + nicotinamide => NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210298", "l": "Interaction of DAP12 and KIR3DS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13987", "l": "ADP + H(+) + O-phospho-L-homoserine => ATP + L-homoserine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62499", "l": "ATP + H(+) + L-arginine <=> diphosphate + L-arginyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73947", "l": "(2E)-geranyl diphosphate = (4E,6E)-allo-ocimene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42122", "l": "5alpha-androstan-3,17-dione + H(+) + NADPH => 17beta-hydroxy-5alpha-androstan-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106417", "l": "dopaminechrome tautomerase activity", "d": ["Catalysis of the reaction: dopaminechrome = 5,6-dihydroxyindole."], "t": []}, {"i": "RHEA:70199", "l": "dopaminechrome = 5,6-dihydroxyindole", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217017", "l": "Deubiquitination of FancD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129375", "l": "Elastin cross-linking by lysyl oxidase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390835", "l": "DRD1,5 bind DA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45800", "l": "15-demethylaclacinomycin T + AH2 + O2 = 10-decarboxymethylaclacinomycin T + A + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69201", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate => ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30038", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH + O2 <=> benzene-1,2,4-triol + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12423", "l": "ATP + D-tagatofuranose 6-phosphate <=> ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218815", "l": "p-6Y-VEGFR2 binds NCK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043808", "l": "lyso-ornithine lipid acyltransferase activity", "d": ["Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl-carrier protein] = ornithine lipid + [acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670155", "l": "CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190256", "l": "FGFR1c binds to FGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60162", "l": "ADP + H(+) + phosphate + vincristine(out) => ATP + H2O + vincristine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654167", "l": "Activated FGFR1 binds PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66270", "l": "AMP + H(+) + nonanoyl-CoA => CoA + nonanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37803", "l": "a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25879", "l": "L-aspartate + O2 <=> H2O2 + iminosuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987214", "l": "p-STAT3 dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29191", "l": "L-aspartate + menaquinone-8 = iminosuccinate + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58342", "l": "chenodeoxycholate + D-glucose => beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24730", "l": "anthranilate + H(+) = aniline + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70348", "l": "bromide + L-tyrosine + NADP(+) => 3-bromo-L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60666", "l": "NADH + phosphate => H2O + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32220", "l": "all-trans-lycopene => gamma-carotene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334160", "l": "UHRF1:Chromatin binds DNMT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49377", "l": "12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.4", "l": "\"ABC-type Na(+) transporter\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1470009", "l": "Phosphorylation of STATs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41361", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine => H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37989", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol => delta-tocopherol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40226", "l": "4,8-dimethylnonanoyl-CoA + H2O <=> 4,8-dimethylnonanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73890", "l": "chloride(out) + Na(+)(out) <=> chloride(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047985", "l": "hydrogen dehydrogenase activity", "d": ["Catalysis of the reaction: H2 + NAD+ = H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41810", "l": "(2E)-butenoyl-[ACP] + H2O => (3R)-hydroxybutanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696267", "l": "RND3 binds GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49403", "l": "H2O + validoxylamine A 7'-phosphate <=> phosphate + validoxylamine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686731", "l": "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40574", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75082", "l": "24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74578", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] <=> N(alpha)-acetyl-L-methionine + N-terminal L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615249", "l": "ARBs bind AGRT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-901047", "l": "Binding of ERp57 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38741", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69634", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21642", "l": "3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH => NADP(+) + prephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31423", "l": "(2Z,6E)-farnesyl diphosphate = (-)-alpha-cedrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15260", "l": "D-threonine <=> acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783670", "l": "CRLF1 binds CLCF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856951", "l": "PP2A demethylation by PPME1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707594", "l": "Hemes bind LY96 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58770", "l": "1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+) => 1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237160", "l": "MTA is cleaved and phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41369", "l": "1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38317", "l": "3-hydroxybenzoate + pyruvate => chorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36851", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12729", "l": "lutein = (3R,3'S)-zeaxanthin", "d": [], "t": []}, {"i": "EC:5.3.3.22", "l": "\"lutein isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-996755", "l": "ZFPM proteins bind GATA proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628444", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27405", "l": "a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2", "d": [], "t": []}, {"i": "EC:1.2.5.1", "l": "\"pyruvate dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23852", "l": "catechol + O2 = cis,cis-muconate + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.1", "l": "\"catechol 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39286", "l": "a long-chain fatty acid(out) <=> a long-chain fatty acid(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24973", "l": "calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28728", "l": "Cu(2+)(in) + H(+)(in) => Cu(2+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52954", "l": "lithocholoyl-24-O-(beta-D-glucuronate) + UDP => lithocholate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156910", "l": "Formation of eEF1B complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38765", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16769", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-glucose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65963", "l": "ATP + H2O + leukotriene C4(out) <=> ADP + H(+) + leukotriene C4(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50624", "l": "acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O = a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-382056", "l": "Crk binds to the active PDGF receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55347", "l": "(9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol <=> 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70501", "l": "PC carboxylates PYR to OA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0044325", "l": "transmembrane transporter binding", "d": ["Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60837", "l": "a 5'-end diphospho-adenosine in mRNA + GTP + H(+) => a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11416", "l": "2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose", "d": [], "t": []}, {"i": "EC:2.3.1.90", "l": "\"beta-glucogallin O-galloyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67264", "l": "(2S,4S)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine = (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64486", "l": "3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA => acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63340", "l": "ATP + L-amino acyl-L-seryl-[protein] = (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429036", "l": "SLC2A9 transports Fru, Glc, urate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663736", "l": "CHRNA9:CHRNA10 binds acetylcholine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14375", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin] => 5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4570528", "l": "SUMOylation of XPC with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388832", "l": "PI3K binds CD28 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983285", "l": "RAD51B binds RAD51C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102479", "l": "quercetin 3-O-beta:-D-galactosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-7-olate + UDP-D-galactose = quercetin 3-O-beta-D-galactopyranoside + UDP(3-) + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67282", "l": "(1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione => (2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72123", "l": "Na(+)(out) + O-butanoyl-(R)-carnitine(out) = Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13010", "l": "H2O + N-formyl-L-kynurenine => formate + H(+) + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40349", "l": "acetyl-CoA + dodecanedioyl-CoA => 3-oxotetradecanedioyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604606", "l": "Unknown kinase phosphorylates NICD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218847", "l": "PAK2 binds NCK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72504", "l": "glutarate(in) + prostaglandin F2alpha(out) => glutarate(out) + prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45562", "l": "D-allo-isoleucine => L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50602", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] => acetyl-CoA + N-terminal L-seryl-[histone H2A]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047132", "l": "dihydrobenzophenanthridine oxidase activity", "d": ["Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15826", "l": "AZD1979 + H2O => AZD1979 oxetane hydrolysis product + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8847977", "l": "FRK phosphorylates PTEN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62543", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + ouabain <=> dihydroouabain + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211239", "l": "Association of DFF40 with chromatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34393", "l": "[beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102418", "l": "luteolin-7-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: luteolin 7-O-beta-D-glucoside + UDP-alpha-D-glucose = luteolin-7-O-gentiobioside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53091", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11768", "l": "diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate", "d": [], "t": []}, {"i": "EC:2.4.2.18", "l": "\"anthranilate phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78622", "l": "L-lysyl-5'-AMP + tRNA(Lys) <=> AMP + H(+) + L-lysyl-tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73002", "l": "H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] <=> L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769235", "l": "MAGED1 binds NPAS4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0070696", "l": "transmembrane receptor protein serine/threonine kinase binding", "d": ["Binding to a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373705", "l": "Caspase cleavage of DCC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096537", "l": "Defective GALNT3 does not transfer GalNAc to mucins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983518", "l": "IL35 binds IL6ST:IL6ST receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31048", "l": "(S)-2-methyl-3-oxopropanoate + CoA + NAD(+) => CO2 + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0051192", "l": "prosthetic group binding", "d": ["Binding to a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051721", "l": "protein phosphatase 2A binding", "d": ["Binding to protein phosphatase 2A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036412", "l": "acetyl-CoA:oxalate CoA-transferase", "d": ["Catalysis of the reaction: acetyl-CoA + oxalate = acetate + oxalyl-CoA."], "t": []}, {"i": "RHEA:37883", "l": "acetyl-CoA + oxalate = acetate + oxalyl-CoA", "d": [], "t": []}, {"i": "EC:2.8.3.19", "l": "\"CoA:oxalate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75941", "l": "4-guanidinobutanoate + L-ornithine => 4-aminobutanoate + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42629", "l": "S-adenosyl-L-methionine + uridine(747) in 23S rRNA => 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381109", "l": "IRE1 binds IRE1 forming dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46543", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18173", "l": "(R)-octopamine = (4-hydroxyphenyl)acetaldehyde + NH4(+)", "d": [], "t": []}, {"i": "EC:4.2.1.87", "l": "\"octopamine dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74339", "l": "O-3-methylbutanoyl-(R)-carnitine(in) = O-3-methylbutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901612", "l": "cardiolipin binding", "d": ["Binding to cardiolipin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34175", "l": "2-hydroxybenzoyl-CoA + malonyl-CoA = 4-hydroxycoumarin + CO2 + 2 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.208", "l": "\"4-hydroxycoumarin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-994148", "l": "LRRC16A binds F-actin capping protein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57153", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 => (3S)-3-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43737", "l": "adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2509831", "l": "ITPA hydrolyses XTP to XMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45012", "l": "H2O + N-octadecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029476", "l": "Role of myosins in phagosome formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201685", "l": "Beta-catenin is released from the destruction complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13819", "l": "2,3-epoxyphylloquinone + [protein]-dithiol => [protein]-disulfide + H2O + phylloquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73651", "l": "CTP(out) = CTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944214", "l": "Association of procollagen type I (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389083", "l": "Autophosphorylation of PDGF alpha receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75849", "l": "SLC25A1 exchanges CIT and MAL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75483", "l": "estrone 3-sulfate(out) + n H(+)(out) = estrone 3-sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210289", "l": "Recruitment of SYK to p-DAP12 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800298", "l": "HGF dimer binds MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019706", "l": "protein-cysteine S-palmitoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15340", "l": "H2O + phenylglyoxylyl-CoA <=> CoA + H(+) + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0070186", "l": "growth hormone activity", "d": ["The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480515", "l": "Expression of FGF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42841", "l": "acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH => 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19286", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + di-trans,poly-cis-dolichol => a 1-acyl-sn-glycero-3-phosphocholine + acyldolichol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139909", "l": "Translocation of BMF to mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43664", "l": "ATP + hydrogencarbonate + tetracosanoyl-CoA = 2-carboxytetracosanoyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109813", "l": "GRB2-1 binds SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769302", "l": "NPAS4 binds INS gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705926", "l": "AR binds AR agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63580", "l": "20-hydroxyecdysone 22-phosphate + H2O = 20-hydroxyecdysone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672168", "l": "Ligand-independent dimerization of PDGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877281", "l": "PIAS1 binds p-STAT1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44388", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688834", "l": "ATXN3 binds VCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445089", "l": "Dephosphorylation of pL1 (Y1176) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4837364", "l": "Secretion of SOD3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015046", "l": "rubredoxin-NADP+ reductase activity", "d": ["Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20747", "l": "NADP(+) + prostaglandin D2 <=> 15-oxoprostaglandin D2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980122", "l": "DTX binds NOTCH1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428260", "l": "DEGS2 oxygenates dihydroceramide (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43916", "l": "(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693347", "l": "HTR1A binds 5HT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16603", "l": "fumarate + NH4(+) => L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24411", "l": "adenosine + H(+) + H2O <=> inosine + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660666", "l": "CBP and p300 binds NF-kB complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56092", "l": "(4Z,15Z)-bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44019", "l": "2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) <=> 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61985", "l": "H(+) + NADH + ubiquinone-10 => NAD(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65407", "l": "butan-1-ol + hexanoyl-CoA <=> butyl hexanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016422", "l": "mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28418", "l": "(R)-carnitine + 4-(trimethylamino)butanoyl-CoA = (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15232", "l": "alpha-D-mannose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62109", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine => a monoacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64929", "l": "dADP + H2O => dAMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58520", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32329", "l": "H(+) + NADH + zerumbone => 10-hydroxy-alpha-humulene + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77451", "l": "hydrogen cyanide + piperonal = (2S)-2-(2H-1,3-benzodioxol-5-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51678", "l": "[protein]-dithiol + 2 AH2 + H(+) + sulfite => [protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626699", "l": "MARK4 binds ODF2 in the centriole (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63187", "l": "NADH + 2 O2 <=> H(+) + NAD(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62617", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose => a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9716947", "l": "ESR1 binds ESR1 agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623023", "l": "AGRP gene expression is stimulated by FOXO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24514", "l": "3-(pyrazol-1-yl)-L-alanine + H2O => L-serine + pyrazole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46483", "l": "4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57447", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0051995", "l": "Se-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the selenium atom of an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25669", "l": "(2E)-geranyl diphosphate <=> beta-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59909", "l": "H2O + hexanal + NADP(+) => 2 H(+) + hexanoate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693478", "l": "HTR1A binds HTR1A agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837978", "l": "LONP1 binds mitochondrial inner membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41910", "l": "(2E)-hexadecenoyl-[ACP] + H2O => (3R)-hydroxyhexadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72583", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) = 3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050439", "l": "2-hydroxy-3-oxoadipate synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H+ = 2-hydroxy-3-oxoadipate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391158", "l": "SIRP alpha binds CD47 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013143", "l": "RAC1 GEFs activate RAC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78148", "l": "a 1,3-diacylglycerol + H2O => a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40552", "l": "demethylphylloquinol + S-adenosyl-L-methionine => H(+) + phylloquinol + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22088", "l": "ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate", "d": [], "t": []}, {"i": "EC:2.7.6.5", "l": "\"GTP diphosphokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38544", "l": "H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] => (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42241", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA => 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71600", "l": "2-oxoglutarate(out) + maleate(in) => 2-oxoglutarate(in) + maleate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2176445", "l": "SMURF2 binds SMAD2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60433", "l": "A + cannabigerolate => AH2 + cannabichromenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9690493", "l": "RHOB binds effectors on endosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793066", "l": "TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3240957", "l": "Formation of PRC2-EZH2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34432", "l": "(+)-secoisolariciresinol + NADP(+) => (-)-lariciresinol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.300", "l": "\"branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53466", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate => 1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50706", "l": "H(+) + NADH + propanal => 1-propanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18217", "l": "2-oxoglutarate + an alkane-alpha,omega-diamine = an omega-aminoaldehyde + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.29", "l": "\"diamine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38281", "l": "(3R)-citramalyl-CoA + succinate => (3R)-citramalate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018786", "l": "haloalkane dehalogenase activity", "d": ["Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189488", "l": "UROS transforms HMB to URO3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49469", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose => a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10108", "l": "(7S)-salutaridinol + NADP(+) = H(+) + NADPH + salutaridine", "d": [], "t": []}, {"i": "EC:1.1.1.248", "l": "\"salutaridine reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444208", "l": "MLNR (GPR38) is a receptor for motilin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73829", "l": "an alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36592", "l": "(S)-2-chloropropanoate + NADP(+) => 2-chloroacrylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55670", "l": "11-cis-retinal--[retinol-binding protein] + H(+) + NADH => 11-cis-retinol--[retinol-binding protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003945", "l": "N-acetyllactosamine synthase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835454", "l": "DNAJC3 binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20060", "l": "2 H(+) + H2O + N-carbamoylsarcosine <=> CO2 + NH4(+) + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24064", "l": "2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen", "d": [], "t": []}, {"i": "EC:4.2.1.24", "l": "\"porphobilinogen synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38518", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033894", "l": "ribonuclease P4 activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38263", "l": "(2R,3S)-beta-methylmalyl-CoA = 2-methylfumaryl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.148", "l": "\"2-methylfumaryl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56109", "l": "genistein + O2 + reduced [NADPH--hemoprotein reductase] => 2'-hydroxygenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68595", "l": "ORC2 binds ORC3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33154", "l": "(R)-dihydrolipoamide + acetyl-CoA <=> (R)-S(6)-acetyldihydrolipoamide + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66422", "l": "ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out) => ATP + glutathione(in) + H2O + tauroursodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43271", "l": "a ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine <=> a ganglioside GM2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73690", "l": "dAMP(out) + phosphate(in) <=> dAMP(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0031544", "l": "peptidyl-proline 3-dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2."], "t": []}, {"i": "REACT:R-HSA-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090729", "l": "toxin activity", "d": ["Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9726949", "l": "PTGIR binds PTGIR agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51509", "l": "2-oxoglutarate + L-proline + O2 => CO2 + succinate + trans-4-hydroxy-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102947", "l": "(+)-delta-cadinene-8-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 = 8-hydroxy-(+)-delta-cadinene + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007546", "l": "E2F6 binds RAD51 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428259", "l": "DEGS1 dehydrogenates dihydroceramide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865774", "l": "TTLLs polyglutamylate tubulin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17373", "l": "all-trans-antheraxanthin = all-trans-capsanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018798", "l": "RHOV binds GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31961", "l": "9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31310", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66637", "l": "(2E,6E)-farnesyl diphosphate + H2O => (-)-alpha-acorenol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018743", "l": "phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity", "d": ["Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11301", "l": "1D-5-O-methyl-myo-inositol + NAD(+) => 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806974", "l": "MET dimers autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.99", "l": "\"4-(gamma-glutamylamino)butanal dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008117", "l": "sphinganine-1-phosphate aldolase activity", "d": ["Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950741", "l": "IL12B:IL23A translocates from ER lumen to extracellular space (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58667", "l": "(S)-2-hydroxyglutarate + a quinone <=> 2-oxoglutarate + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13161", "l": "L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.103", "l": "\"L-threonine 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640316", "l": "DeHA hydrolyses to threonate and oxalate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004324", "l": "ferredoxin-NADP+ reductase activity", "d": ["Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32958", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60140", "l": "dodecanoyl-CoA + H(+) + malonyl-CoA = 3-oxotetradecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13091", "l": "6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite => 6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18754", "l": "[protein]-dithiol + NADP(+) => [protein]-disulfide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32513", "l": "(3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+) => (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70459", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2 = a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38464", "l": "a 1-acyl-sn-glycerol + an acyl-CoA => a 1,2-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111237", "l": "Formation of ADAR1 homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615945", "l": "RAN:GTP binds TNPO1/KPNB1 (transportin/importin beta) associated with the Nup107-160 complex and releases Nup107-160  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35259", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177942", "l": "EGFR binds EGF ligand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857686", "l": "FITM1, FITM2 bind TAGs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62486", "l": "2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602454", "l": "proMMP9 binds TIMP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33760", "l": "a 3-oxo-fatty acyl-CoA + H(+) + NADPH => a 3-hydroxy-fatty acyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44120", "l": "hexadecanoyl-CoA + octadecan-1-ol = CoA + octadecanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74435", "l": "a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out) = a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38672", "l": "sphinganine 1-phosphate(in) => sphinganine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086077", "l": "gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390649", "l": "CHRM1,3,5 bind acetylcholine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737111", "l": "Protonated weak acid translocates across the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9835411", "l": "FA core complex:HSP70s binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430308", "l": "PARVB interacts with Alpha-actinin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35827", "l": "H2O + N(1)-(3-aminopropyl)agmatine = spermidine + urea", "d": [], "t": []}, {"i": "EC:3.5.3.24", "l": "\"N(1)-aminopropylagmatine ureohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15267", "l": "H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate => 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63186", "l": "H(+) + NAD(+) + 2 superoxide => NADH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327733", "l": "FN1 binds Collagen types I-V, VII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626681", "l": "Recruitment of transition zone proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48424", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683593", "l": "ATG7:ATG3:LC3 dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73434", "l": "(2S)-sakuranetin + O2 + reduced [NADPH--hemoprotein reductase] <=> (2S)-7-methylcarthamidin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848818", "l": "PTK6 phosphorylates CBL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948536", "l": "PTENP1 mRNA binds miR-20 RISC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48845", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25652", "l": "(2R,5R)-isopulegone + NADP(+) <=> (6R)-isopiperitenone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0003975", "l": "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0017076", "l": "purine nucleotide binding", "d": ["Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437936", "l": "p-Y348-SYK phosphorylates VAV family (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9851946", "l": "FIRRM binds PLK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215144", "l": "TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008035", "l": "high-density lipoprotein particle binding", "d": ["Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202328", "l": "Translocation of PKC theta to plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047022", "l": "7-beta-hydroxysteroid dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + a 7-beta-hydroxysteroid = NADPH + H+ + a 7-oxosteroid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23356", "l": "ATP + L-seryl-[rhodopsin] = ADP + H(+) + O-phospho-L-seryl-[rhodopsin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45522", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit] => phycoviolobilin-L-cysteinyl(84)-[phycoerythrocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047507", "l": "(deoxy)nucleoside-phosphate kinase activity", "d": ["Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047466", "l": "2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity", "d": ["Catalysis of the reaction: cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.2.4", "l": "\"purine imidazole-ring cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45351", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382055", "l": "Grb7 binds to the active PDGF receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140769", "l": "factor VII -> factor VIIa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419428", "l": "S1PR2-5 bind S1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60200", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate", "d": [], "t": []}, {"i": "EC:1.14.11.66", "l": "\"[histone H3]-trimethyl-L-lysine(9) demethylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21343", "l": "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 <=> 2 vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76578", "l": "4-deoxy-L-threo-hex-4-enopyranuronate <=> 5-dehydro-4-deoxy-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030023", "l": "extracellular matrix constituent conferring elasticity", "d": ["A component of the extracellular matrix that enables the matrix to recoil after transient stretching."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30351", "l": "H(+) + NADH + O2 + pyrrole-2-carboxylate = 5-hydroxypyrrole-2-carboxylate + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.130", "l": "\"pyrrole-2-carboxylate monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49407", "l": "beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate <=> alpha-D-mannose 1-phosphate + D-mannose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73123", "l": "isorhamnetin + S-adenosyl-L-methionine = H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956659", "l": "ABL1 phosphorylates YAP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111919", "l": "PKA phosphorylates CREB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44336", "l": "an L-alpha-amino acid + ATP + L-arginine = ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.48", "l": "\"L-arginine-specific L-amino acid ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56177", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O => 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19258", "l": "a secondary alcohol + NADP(+) => a ketone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52776", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.52", "l": "\"camalexin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.50", "l": "\"C-glycoside oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48610", "l": "a 2,3-dehydroacyl-CoA + AH2 => A + a 2,3-saturated acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18881", "l": "ATP + histamine + L-glutamate = ADP + H(+) + N(alpha)-gamma-L-glutamylhistamine + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.18", "l": "\"gamma-glutamylhistamine synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13473", "l": "H2O + L-tryptophan + NAD(+) = H(+) + indole-3-pyruvate + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65378", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917811", "l": "STEAP3,STEAP4 reduce Fe3+ to Fe2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60963", "l": "18-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose <=> (9Z)-18-hydroxyoctadec-9-enoate 18-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68788", "l": "(2Z,6Z)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033913", "l": "glucan endo-1,2-beta-glucosidase activity", "d": ["Catalysis of the random hydrolysis of (1->2)-glucosidic linkages in (1->2)-beta-D-glucans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1006143", "l": "CD46 binds C3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008866", "l": "fructuronate reductase activity", "d": ["Catalysis of the reaction: D-mannonate + NAD+ = D-fructuronate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866269", "l": "ARRB bind GPCRs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23094", "l": "ethylamine + N-isopropylammelide => H(+) + H2O + hydroxyatrazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66449", "l": "(E)-pent-2-en-1-ol + NADP(+) => (E)-2-pentenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27664", "l": "2-oxoglutarate + H2O2 => (S)-2-hydroxyglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50124", "l": "NAD(+) + resolvin D1 = 8-oxoresolvin D1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24078", "l": "a 3-oxo-Delta(5)-steroid + H(+) + NADH => a 3beta-hydroxy-Delta(5)-steroid + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29851", "l": "H2O + UDP-N-acetyl-alpha-D-galactosamine = 2 H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69001", "l": "3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine => 3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47218", "l": "6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33493", "l": "CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine => 2-hydroxyhexacosanoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61618", "l": "formaldehyde + H2O + N-methyl-L-proline + NAD(+) => H(+) + L-proline betaine + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20708", "l": "ATP + erythritol = ADP + D-erythritol 4-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.27", "l": "\"erythritol kinase (D-erythritol 4-phosphate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102986", "l": "trehalose synthase activity", "d": ["Catalysis of the reaction: an NDP-alpha-D-glucose + D-glucopyranose = alpha,alpha-trehalose + H+ + a nucleoside diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36556", "l": "eicosanoyl-CoA + sphinganine => CoA + H(+) + N-eicosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57572", "l": "7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47191", "l": "Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol <=> hydrogen sulfide + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30020", "l": "ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A => ADP + H(+) + lipid A-core", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879327", "l": "acetylglucosamine-inositol is deacetylated by Mca (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38353", "l": "3-phenylpyruvate + H(+) + NADH => (R)-3-phenyllactate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14228", "l": "6-hydroxyhexanoate + NAD(+) <=> 6-oxohexanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236954", "l": "Trimming of peptides by IRAP in endocytic vesicles (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54970", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + phosphate => hexadecanoyl phosphate + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16877", "l": "3-sulfino-L-alanine + H(+) = CO2 + hypotaurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43740", "l": "ATP + CoA + hexanoate = AMP + diphosphate + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627078", "l": "XIAP binds CASP9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25709", "l": "H(+) + N,N-dihydroxy-L-dihomomethionine <=> (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65148", "l": "phloretin + UDP-alpha-D-glucose = H(+) + trilobatin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016005", "l": "phospholipase A2 activator activity", "d": ["Binds to and increases the activity of the enzyme phospholipase A2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203130", "l": "OLR1 binds to oxidized LDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373732", "l": "Nephrin trans-homophilic interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665871", "l": "ADRM1 binds 26S proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507871", "l": "Aquaporins passively transport glycerol out of cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392834", "l": "Activation of EPACs by cAMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10649", "l": "2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 => 6-hydroxyhexan-6-olide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36817", "l": "dTDP-alpha-D-fucofuranose => dTDP-alpha-D-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211874", "l": "CYP2S1 4-hydroxylates atRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043915", "l": "L-seryl-tRNA(Sec) kinase activity", "d": ["Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34399", "l": "9-cis-beta-carotene + O2 = 9-cis-10'-apo-beta-carotenal + beta-ionone", "d": [], "t": []}, {"i": "EC:1.13.11.68", "l": "\"9-cis-beta-carotene 9',10'-cleaving dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653840", "l": "POLD,POLE complete replication of damaged DNA after TLS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102355", "l": "2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase activity", "d": ["Catalysis of the reaction: 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O = 3-maleylpyruvate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047663", "l": "aminoglycoside 6'-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + kanamycin B = N(6')-acetylkanamycin B + CoA + H+. This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64647", "l": "butan-1-ol + propanoyl-CoA <=> butyl propanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016652", "l": "oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP."], "t": []}, {"i": "EC:1.6.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140760", "l": "histone H3K56me2/H3K56me3 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 56 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38770", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26014", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate = 3-dehydroquinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61665", "l": "(2E,6E,10E)-geranylgeraniol + ATP => (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940554", "l": "MMP2 cleaves OPTC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53650", "l": "(+)-corvol ether A + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75992", "l": "a dicarboxylate(in) + N-benzoylglycine(out) => a dicarboxylate(out) + N-benzoylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63149", "l": "H2O + N-(9Z-octadecenoyl)-taurine => (9Z)-octadecenoate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42471", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O <=> 2-oxopent-4-enoate + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097079", "l": "selenite:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0005302", "l": "L-tyrosine transmembrane transporter activity", "d": ["Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15005", "l": "2-oxoglutarate + gibberellin A1 + O2 = CO2 + gibberellin A8 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.13", "l": "\"gibberellin 2beta-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69268", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate = an alkenyl isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57757", "l": "2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH => C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25713", "l": "2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase] => L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28499", "l": "formaldehyde + mycothiol => S-(hydroxymethyl)mycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72984", "l": "dimethylallyl diphosphate + harmol => 6-(3-dimethylallyl)harmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420975", "l": "Ca impermeable AMPA receptor ligand binding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36785", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine => L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21156", "l": "(2R)-2-phosphoglycerate + H2O = (R)-glycerate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.20", "l": "\"phosphoglycerate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22228", "l": "H(+) + NADH + presqualene diphosphate = diphosphate + NAD(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56053", "l": "2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => 2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.1", "l": "\"unspecific peroxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45816", "l": "(S)-lactate + A = AH2 + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47350", "l": "an aliphatic alcohol + butanoate + H(+) => a butanoate ester + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14210", "l": "alpha-D-galactose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114284", "l": "Release of Cytochrome c from mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798372", "l": "ATM phosphorylates DYRK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52653", "l": "lanosterol + S-adenosyl-L-methionine => eburicol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.7.4", "l": "\"4-hydroxy-3-methylbut-2-enyl diphosphate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205238", "l": "SHP2 interacts with p-KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140481", "l": "ABC-type iron-sulfur cluster transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out)."], "t": []}, {"i": "TCDB:3.A.1.210.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62383", "l": "carbaryl + H(+) + H2O <=> 1-naphthol + CO2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29581", "l": "Fe(2+)(out) + H(+)(out) => Fe(2+)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842666", "l": "Active LTK phosphorylates IRS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23778", "l": "4-phospho-L-aspartate + ADP => ATP + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53985", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O => (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380586", "l": "loading of Serotonin in synaptic vesicles (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71266", "l": "chloride(out) + L-proline(out) + 2 Na(+)(out) <=> chloride(in) + L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55697", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O => an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9861631", "l": "ME1 tetramerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32629", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29397", "l": "diphosphate + H(+) + UMP => H2O + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35489", "l": "2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44315", "l": "1-tetradecanoylglycerol + H2O <=> glycerol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022462", "l": "MECP2 mutants R133C ,D121G, R133H and S134F do not bind 5hmC-DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12966", "l": "ATP + D-galacturonate => 1-phospho-alpha-D-galacturonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25740", "l": "N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621410", "l": "HMGCR gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74986", "l": "Elongation of pre-rRNA transcript (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15771", "l": "adenosylcob(III)inamide phosphate + ADP + H(+) => adenosylcob(III)inamide + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102029", "l": "D-lactate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: (R)-lactate + an ubiquinone = pyruvate + an ubiquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69515", "l": "H2O + N-acetyl-D-galactosamine + O2 <=> H(+) + H2O2 + N-acetyl-D-galactosaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51105", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30047", "l": "chloroacetaldehyde + H2O + NAD(+) = chloroacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19309", "l": "2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = (2R)-2-O-(alpha-D-mannosyl)-glycerate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.70", "l": "\"mannosyl-3-phosphoglycerate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47475", "l": "(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH <=> (3E)-tetradecenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029453", "l": "Phosphorylation of VAV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031546", "l": "brain-derived neurotrophic factor receptor binding", "d": ["Binding to a brain-derived neurotrophic factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74827", "l": "UDP-alpha-D-galacturonate(in) + UMP(out) = UDP-alpha-D-galacturonate(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72126", "l": "Na(+)(out) + O-butanoyl-(R)-carnitine(out) <=> Na(+)(in) + O-butanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809309", "l": "MTMR6 binds MTMR9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888577", "l": "Synthesis of GABA by GAD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9619376", "l": "CAMK1 binds calmodulin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25408", "l": "ADP-alpha-D-glucose + D-glucose = ADP + alpha,alpha-trehalose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33981", "l": "D-glucose + DIBOA => DIBOA beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38301", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398184", "l": "LARG activation by G alpha 12/13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "51.050078789600256", "identifiers": [{"i": "GO:0046873", "l": "metal ion transmembrane transporter activity", "d": ["Enables the transfer of metal ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52520", "l": "O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33935", "l": "2 N(omega)-hydroxy-L-arginine + NADH + 2 O2 = H(+) + 2 H2O + 2 L-citrulline + NAD(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604642", "l": "Proteasome degrades ubiquitinated NICD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047712", "l": "Cypridina-luciferin 2-monooxygenase activity", "d": ["Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626914", "l": "α2-agonists bind ADRA2A,B,C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59346", "l": "D-maltobiono-1,5-lactone + H2O2 => D-maltose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54183", "l": "a long-chain fatty aldehyde + holo-[ACP] + NAD(+) <=> a long-chain fatty acyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141437", "l": "Formation of the MCC complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41219", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69395", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17727", "l": "2-methyl-cis-aconitate + H2O => (2S,3S)-2-methylcitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31651", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428260", "l": "DEGS2 oxygenates dihydroceramide (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551453", "l": "PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592362", "l": "Activation of proMMP7 by MMP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72278", "l": "oxalate(in) + sulfate(out) <=> oxalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693608", "l": "Initial resection of double-strand break ends (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60835", "l": "a 5'-end triphospho-guanosine in mRNA + H2O <=> a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0046027", "l": "phospholipid:diacylglycerol acyltransferase activity", "d": ["Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59836", "l": "H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] = 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10871", "l": "a 1,2-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140608", "l": "cysteine-type endopeptidase activator activity", "d": ["Binds to and increases the activity of a cysteine-type endopeptidase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54027", "l": "2-oxoglutarate + L-histidyl-[ribosomal protein uL15] + O2 <=> (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58686", "l": "FADH2-C4alpha-hydroperoxide + NADP(+) => FAD + 2 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35443", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose = an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.51", "l": "\"anthocyanidin 3-O-glucoside 2'''-O-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624800", "l": "CDK1 phosphorylates LBR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17472", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester + apo--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16927", "l": "(E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine => (E)-caffeoyl-CoA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.4.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901641", "l": "ITP binding", "d": ["Binding to ITP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655830", "l": "Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37083", "l": "[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine = [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69471", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose <=> L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102064", "l": "gamma-curcumene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = gamma-curcumene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11128", "l": "4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18135", "l": "adenosine 5'-phosphosulfate + diphosphate => ATP + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52379", "l": "(+)-sesamin monocatechol + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) <=> (+)-sesamin dicatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17061", "l": "H(+) + NADPH + O2 + phenol = catechol + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.7", "l": "\"phenol 2-monooxygenase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3782535", "l": "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28741", "l": "Cd(2+)(out) + H(+)(in) => Cd(2+)(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56030", "l": "3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => 3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22973", "l": "butanal + CoA + NADP(+) => butanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66242", "l": "AMP + diphosphate + IC-asc-C9-CoA => ATP + CoA + IC-asc-C9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75262", "l": "isoorientin + O2 <=> 3''-dehydroisoorientin + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16879", "l": "CO2 + hypotaurine => 3-sulfino-L-alanine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1011598", "l": "DOCKs bind to RhoGEFs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77911", "l": "a 3'-end 2'-deoxyribonucleotidyl-deoxyribonucleotide-DNA + H2O = a 2'-deoxyribonucleoside 5'-phosphate + a 3'-end 2'-deoxyribonucleotide-DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75904", "l": "ADP-D-glycero-beta-D-manno-heptose + L-seryl-[protein] => ADP + H(+) + O-(D-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70421", "l": "3,4-dihydroxyphenylacetate + CoA + H(+) => 3,4-dihydroxyphenylacetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004931", "l": "extracellularly ATP-gated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."], "t": []}, {"i": "REACT:R-HSA-877187", "l": "P2X7 mediates loss of intracellular K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392751", "l": "L1 linked to actin cytoskeleton by ankyrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939066", "l": "PRKCB gene expression is stimulated by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.423", "l": "\"(1R,2S)-ephedrine 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218832", "l": "CDC42:GTP binds PAK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210439", "l": "glutamate uptake by astrocytes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938217", "l": "RUNX1 binds the SWI/SNF complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.29", "l": "\"aureolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425577", "l": "Na+-driven Cl-/HCO3- exchanger transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429732", "l": "Multiphospho-CERT1-2 binds PPM1L, VAPA/B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25032", "l": "ADP-alpha-D-ribose 1''-phosphate + H2O <=> ADP-D-ribose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168869", "l": "Budding of vesicle with the HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum into the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23956", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9639286", "l": "RRAGC,D exchanges GTP for GDP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37394", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16628", "l": "acetyl-CoA + hydrogen sulfide <=> CoA + thioacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10153", "l": "ATP + hydrogencarbonate + NH4(+) => ADP + carbamoyl phosphate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936851", "l": "AHRR binds ARNT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22272", "l": "(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.121", "l": "\"protopanaxadiol 6-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74250", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24464", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189406", "l": "4 PBGs bind to form HMB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77155", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864569", "l": "WWOX binds TFAP2C (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202443", "l": "Oligomerization of CARMA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42312", "l": "H(+) + NADP(+) + 2 reduced [adrenodoxin] = NADPH + 2 oxidized [adrenodoxin]", "d": [], "t": []}, {"i": "EC:1.18.1.6", "l": "\"adrenodoxin-NADP(+) reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57521", "l": "15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] => 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47046", "l": "acetoacetate + N,N,N-trimethylglycyl-CoA => 3-dehydrocarnitine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358789", "l": "Self-ubiquitination of RNF41 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804099", "l": "HMGB1 binds LTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52781", "l": "H2O + S-(hercyn-2-yl)-L-cysteine S-oxide => 2-sulfenohercynine + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21607", "l": "styrene oxide <=> 2-phenylacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28555", "l": "D-mannose 6-phosphate + H2O => D-mannose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21809", "l": "2,5-dioxopiperazine + H2O => glycylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009029", "l": "tetraacyldisaccharide 4'-kinase activity", "d": ["Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + ATP = ADP + 2 H+ + lipid IV(a)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649856", "l": "Oxidative damage to the AP site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322434", "l": "XIAP dissociates from ub-TLE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77546", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA <=> 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67823", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.61064910827011", "identifiers": [{"i": "GO:0050839", "l": "cell adhesion molecule binding", "d": ["Binding to a cell adhesion molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26335", "l": "2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 4 H(+) + molybdopterin => 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + cyclic pyranopterin phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031852", "l": "mu-type opioid receptor binding", "d": ["Binding to a mu-type opioid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.-", "l": "\"Transferring alkyl or aryl groups, other than methyl groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796626", "l": "MIB2 ubiquitinates CFLAR  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43315", "l": "ATP + N-(hexanoyl)sphing-4-enine <=> ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14886", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] => ADP-D-ribose + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49096", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine = 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine", "d": [], "t": []}, {"i": "EC:1.21.98.3", "l": "\"anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797810", "l": "PTPRD binds IL1RAPL1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220978", "l": "FBXW7 WD mutants do not bind NICD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75872", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67457", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40040", "l": "2 ATP + 2 L-glutamate + N-acetyl-L-aspartate => 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47225", "l": "dehydroepiandrosterone 3-sulfate + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxydehydroepiandrosterone 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37798", "l": "2 H(+) + 2 NADPH + O2 <=> 2 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036289", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6790454", "l": "SUMOylation of XPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651828", "l": "PARG dePARylates PARP1,PARP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875558", "l": "RAPGEF1 binds CRK,CRKL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204873", "l": "Interaction of Tie2 and Shp2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59122", "l": "2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2 => 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59396", "l": "L-leucine = D-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57983", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose <=> (20S)-ginsenoside F1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23265", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADP(+) => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0005283", "l": "amino acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50916", "l": "a carboxylate + ATP + H(+) + NADPH = AMP + an aldehyde + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11306", "l": "glyoxylate + urea => (S)-ureidoglycolate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28486", "l": "Fe(2+)(in) = Fe(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.109", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788628", "l": "p-Y-STATs dissociate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149454", "l": "Packaging of HIV virion on the host cell plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60760", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone = CoA + jasmolin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9845538", "l": "ST3GAL2,3 transfer Neu5Ac to gangliosides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39492", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH => (11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73721", "l": "H(+) + S-adenosyl-L-homocysteine + vanillate => 3,4-dihydroxybenzoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28748", "l": "NH4(+)(in) => NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48007", "l": "1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 <=> 3,4-dimethoxybenzaldehyde + glycolaldehyde + guaiacol + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10690", "l": "phosphate + streptomycin => H2O + streptomycin 6-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34344", "l": "(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.16.1", "l": "\"spleen exonuclease\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625426", "l": "Retrograde IFT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801101", "l": "RABGGTA binds RABGGTB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159771", "l": "Furin cleaves pro-protein C to protein C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675656", "l": "EDA:EDAR binds EDARADD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061768", "l": "magnesium:sodium antiporter activity", "d": ["Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047834", "l": "D-threo-aldose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17911", "l": "acetaldehyde + formate => (S)-lactate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14870", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O => acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38043", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.11", "l": "\"acyl-[acyl-carrier-protein] 4-desaturase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928625", "l": "PAKs autophosphorylate (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005161", "l": "platelet-derived growth factor receptor binding", "d": ["Binding to a platelet-derived growth factor receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696183", "l": "AOC3 deaminates BZAM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76975", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O = (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334794", "l": "FABPs bind LCFAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52012", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48282", "l": "a ganglioside GM1 + H(+) + UDP => a ganglioside GM2 + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53505", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine => 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322434", "l": "XIAP dissociates from ub-TLE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22554", "l": "adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+) => 3'-phosphoadenylyl sulfate + an alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18204", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984001", "l": "IL35 binds IL27RA:IL12RB2 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45751", "l": "(3Z)-hexenoyl-CoA <=> (2E)-hexenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26449", "l": "3-oxopropanoate + CoA + NADP(+) <=> H(+) + malonyl-CoA + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6813740", "l": "GDE1 hydrolyzes GroPIns (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68129", "l": "a fatty acyl-CoA + phytol => a fatty acid phytyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11489", "l": "all-trans-retinol + an acyl-CoA => an all-trans-retinyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44106", "l": "decanoate + 2 H(+) + NADH => decanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020610", "l": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4420117", "l": "VEGFR2 autophosphorylates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70073", "l": "(22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + sitosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5591086", "l": "SERPINA5 binds activated protein C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69574", "l": "2'-deoxyinosine + IMP => dIMP + inosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9751024", "l": "SLC29A1,2 transport 6MP from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004373", "l": "glycogen (starch) synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665998", "l": "MKL1 binds SRF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611751", "l": "β1,2-agonists bind ADRB1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71097", "l": "2 Na(+)(in) + pregnenolone sulfate(in) => 2 Na(+)(out) + pregnenolone sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2545196", "l": "FN1 dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-994148", "l": "LRRC16A binds F-actin capping protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12001", "l": "formate + NADP(+) => CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390011", "l": "HPO dimer binds to SAV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120086", "l": "(3S)-(+)-asterisca-2(9),6-diene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (3S)-(+)-asterisca-2(9),6-diene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110157", "l": "UNG glycosylase mediated recognition and binding of a 5-hydroxyuracil opposite to a guanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159443", "l": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12160", "l": "2-deoxy-D-gluconate + NAD(+) = 3-dehydro-2-deoxy-D-gluconate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.125", "l": "\"2-deoxy-D-gluconate 3-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619838", "l": "ARC binds DNM2 and SH3GL3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658231", "l": "RAS GAPs stimulate RAS GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17953", "l": "3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde", "d": [], "t": []}, {"i": "EC:1.13.11.6", "l": "\"3-hydroxyanthranilate 3,4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.5.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35232", "l": "rifampicin(in) => rifampicin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655284", "l": "Activated FGFR4 mutants phosphorylate FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199093", "l": "CXADR binds to AMICA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852324", "l": "GTSE1 binds PLK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46068", "l": "(3E)-nonenoyl-CoA = (2E)-nonenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70165", "l": "H(+)(out) + methotrexate(out) => H(+)(in) + methotrexate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097322", "l": "7SK snRNA binding", "d": ["Binding to a 7SK small nuclear RNA (7SK snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420975", "l": "Ca impermeable AMPA receptor ligand binding (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75093", "l": "2 chloride(out) + sulfate(in) => 2 chloride(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26298", "l": "1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24660", "l": "H(+) + L-arginine + NADPH + O2 = H2O + N(omega)-hydroxy-L-arginine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399946", "l": "Recruitment and activation of Cdk5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102141", "l": "[chondroitin sulfate]-D-glucuronyl 2-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [chondroitin-sulfate]-beta-D-glucuronate = adenosine 3',5'-bismonophosphate + [chondroitin-sulfate]-2-O-sulfo-beta-D-glucuronate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74097", "l": "ADP + an L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836275", "l": "TFAP2A binds TFAP2B (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950201", "l": "Expression of Aryl Hydrocarbon receptor-interacting protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043014", "l": "alpha-tubulin binding", "d": ["Binding to the microtubule constituent protein alpha-tubulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58194", "l": "dihydrobisanhydrobacterioruberin + diphosphate => dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46441", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 => A + a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707683", "l": "PGRMC2 binds Hemes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31282", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40788", "l": "H2O + tetracosanoyl-CoA => CoA + H(+) + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74769", "l": "3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + syringetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71057", "l": "L-cysteine(in) + L-methionine(out) => L-cysteine(out) + L-methionine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28299", "l": "(2E,6E)-farnesyl diphosphate => (E)-gamma-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25798", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamate => 2-oxoglutarate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21035", "l": "glucuronate acceptor + UDP-alpha-D-glucuronate <=> acceptor beta-D-glucuronoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005174", "l": "CD40 receptor binding", "d": ["Binding to CD40, a receptor found on the surface of all B-lymphocytes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694476", "l": "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533944", "l": "Fibronectin degradation by MMP10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865454", "l": "CBFB binds RUNX3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51283", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate <=> (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866851", "l": "CFTR transits to the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015413", "l": "ABC-type nickel transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014129", "l": "HEY1 gene expression is positively regulated by NOTCH3 and STAT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004061", "l": "arylformamidase activity", "d": ["Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31575", "l": "8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.55", "l": "\"8-oxo-dGTP diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71757", "l": "2-oxoglutarate(in) + 2-oxoheptanedioate(out) => 2-oxoglutarate(out) + 2-oxoheptanedioate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.116", "l": "\"SpoIVB peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102987", "l": "palmitoleic acid delta 12 desaturase activity", "d": ["Catalysis of the reaction: palmitoleoyl-CoA + O2 + a reduced electron acceptor = (9Z,12Z)-hexadecadienoyl-CoA + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65399", "l": "8-oxo-dATP + H2O <=> 8-oxo-dAMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931981", "l": "RUNX1 binds ESR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25157", "l": "(R)-4'-phosphopantothenate + ATP + L-cysteine => AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604368", "l": "Autocatalytic activation of bound proMMP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32149", "l": "6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+) => H2O + sepiapterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51250", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67246", "l": "2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH => 3-deoxyglucosone + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004996", "l": "thyroid-stimulating hormone receptor activity", "d": ["Combining with thyroid-stimulating hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34661", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine => C30 botryococcene + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617829", "l": "Assembly of IFT A complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16364", "l": "2-acetolactate <=> 3-hydroxy-3-methyl-2-oxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66418", "l": "ADP + glutathione(out) + glycoursodeoxycholate(out) + H(+) + phosphate => ATP + glutathione(in) + glycoursodeoxycholate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2203480", "l": "COLEC11 binds ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5695964", "l": "ABHD14B hydrolyses PNPB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31308", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-877281", "l": "PIAS1 binds p-STAT1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25804", "l": "H2O + O2 + spermine = 3-aminopropanal + H2O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.12", "l": "\"envelysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168885", "l": "Haptoglobin binds Hemoglobin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69923", "l": "castasterone + O2 + reduced [NADPH--hemoprotein reductase] = brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55361", "l": "11-cis-retinol => 9-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10698", "l": "AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase] => a long-chain fatty acid + ATP + holo-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629679", "l": "PDE3A inhibitors bind PDE3A (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33292", "l": "L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875523", "l": "MET binds TNS3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13281", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.178", "l": "\"3-hydroxy-2-methylbutyryl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50266", "l": "26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53230", "l": "16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63903", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) <=> (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47456", "l": "(3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+) = 3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0004558", "l": "alpha-1,4-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45127", "l": "acarbose + ATP <=> acarbose 7(IV)-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098744", "l": "1-phosphatidylinositol 4-kinase activator activity", "d": ["Binds to and increases the activity of 1-phosphatidylinositol 4-kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-181450", "l": "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22707", "l": "2 H2O + ricinine <=> 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79118", "l": "L-arginine + taurocholate <=> L-arginocholate + taurine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.19", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54456", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70484", "l": "2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2 => a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59640", "l": "D-xylotetraose + O2 = D-xylotetraono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15019", "l": "an alcohol + phosphate => a phosphate monoester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47397", "l": "H2O + octadecanoate ester => an aliphatic alcohol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462041", "l": "HNP1-4 are released into phagocytic vacuoles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.52", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45166", "l": "2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.100", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42634", "l": "5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003862", "l": "3-isopropylmalate dehydrogenase activity", "d": ["Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015136", "l": "sialic acid transmembrane transporter activity", "d": ["Enables the transfer of sialic acid from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37632", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29279", "l": "H(+) + menaquinol-8 + trimethylamine N-oxide = H2O + menaquinone-8 + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730841", "l": "Phosphorylation and activation of VAV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20578", "l": "3-hydroxyaminophenol => aminohydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070967", "l": "coenzyme F420 binding", "d": ["Binding to F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807872", "l": "Active ARF recruits coatomer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209076", "l": "SPZ dimer bound TL dimerises at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15492", "l": "adenosine + H2O + 2 O2 <=> 9-riburonosyladenine + H(+) + 2 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65581", "l": "H2O + TTP => H(+) + phosphate + TDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77789", "l": "2-dehydro-D-glucose + an aliphatic amine + H2O2 => an N-(1-deoxy-beta-D-fructopyranos-1-yl)amine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69931", "l": "inosine(out) + Na(+)(out) = inosine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.139", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685319", "l": "CX3 complex formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23516", "l": "(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.31", "l": "\"glycerate 3-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68482", "l": "CO2 + H2O + pentadecanal => (2R)-2-hydroperoxyhexadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41930", "l": "NADP(+) + octadecanoyl-[ACP] => (2E)-octadecenoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0070547", "l": "L-tyrosine aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39904", "l": "isoxazolin-5-one + O-acetyl-L-serine => 3-(5-oxoisoxazolin-4-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20910", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77586", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol <=> 1-octadecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28919", "l": "4-aminobutanoate(in) + L-glutamate(out) = 4-aminobutanoate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003743", "l": "translation initiation factor activity", "d": ["Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202325", "l": "Recruitment of Gads to LAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66159", "l": "butanoyl-CoA + tyramine <=> CoA + H(+) + N-butanoyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693751", "l": "FAAH2 hydrolyses AEA to AA and ETA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53780", "l": "beta-muricholate + lithocholoyl-CoA = beta-muricholoyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55282", "l": "13-cis-retinyl tetradecanoate + CoA => 13-cis-retinol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-165680", "l": "Formation of active mTORC1 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.99", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78672", "l": "(3R)-3-hydroxydodecanoyl-CoA + NAD(+) => 3-oxododecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17617", "l": "leukotriene C4 = glutathione + leukotriene A4", "d": [], "t": []}, {"i": "EC:4.4.1.20", "l": "\"leukotriene-C4 synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863914", "l": "Transport of SEC22B, TAP and PLC from ER to ERGIC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78700", "l": "a 3-O-beta-D-glucosyl-beta-D-glucuronoside + phosphate => a beta-D-glucuronoside + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5666001", "l": "Profilin:G-actin binds MKL1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204798", "l": "Interaction of Tie2 and p85 of PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39587", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44310", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74697", "l": "(5R)-hydroxy-beta-trans-bergamotene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-exo-beta-bergamotene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21728", "l": "GDP-alpha-D-mannose + H2O + 2 NAD(+) = GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH", "d": [], "t": []}, {"i": "EC:1.1.1.132", "l": "\"GDP-mannose 6-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70473", "l": "a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62332", "l": "ADP + ATP = adenosine 3'-diphosphate,5'-diphosphate + AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52250", "l": "12 H(+) + 4 MnO2 => 6 H2O + 4 Mn(3+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70298", "l": "2-oxoglutarate + 3-sulfino-L-alanine <=> 3-sulfinopyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.776644720617639", "identifiers": [{"i": "GO:0004518", "l": "nuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56823", "l": "AH2 + cyclooctat-9-en-7-ol + O2 <=> A + cyclooctat-9-ene-5,7-diol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23907", "l": "an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] <=> 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.48", "l": "\"cerevisin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796046", "l": "NFkB dependent NFE2L2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43342", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase] => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.202618949668349", "identifiers": [{"i": "GO:0034061", "l": "DNA polymerase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43507", "l": "5-hydroxymethylfurfural + O2 <=> 2,5-diformylfuran + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5334827", "l": "SUMO-CRABP2 binds atRA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68382", "l": "2-oxosuccinamate + L-serine => 3-hydroxypyruvate + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3601585", "l": "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621370", "l": "SYK autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832334", "l": "WT1 binds the PAX2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623521", "l": "RAB3IP stimulates nucleotide exchange on RAB8A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30310", "l": "7-methylxanthine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002428", "l": "Removal of fibrillar collagen N-propeptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27419", "l": "6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+) => 2 Fe(III)-[cytochrome] + H2O + nicotinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23486", "l": "AH2 + D-cellobiono-1,5-lactone => A + D-cellobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56369", "l": "3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 => 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856871", "l": "MDH1 reduces OA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798374", "l": "DYRK2 phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685838", "l": "CX3 complex binds D-loop structures (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60744", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-pyrethrolone = CoA + pyrethrin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69942", "l": "6-deoxotyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxytyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37799", "l": "2 H(+) + 2 NADH + O2 = 2 H2O + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.77", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809707", "l": "MTMR12 binds MTMR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25448", "l": "(2E,6E)-farnesyl diphosphate = (+)-guaia-6,9-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028284", "l": "Phosphorylation of STK4 (MST1) and SAV1 by STK4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.615305434222648", "identifiers": [{"i": "GO:0060090", "l": "molecular adaptor activity", "d": ["The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35007", "l": "D-fucose(in) = D-fucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57408", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NAD(+) = 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39029", "l": "a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10007", "l": "benzyl isothiocyanate <=> benzyl thiocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47755", "l": "5-hydroxy-3-methyl-L-tyrosine + S-adenosyl-L-methionine <=> 5-hydroxy-3-methyl-O-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989754", "l": "Expression of APOA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39094", "l": "(2E)-decenedioyl-CoA + H2O <=> (3S)-hydroxydecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018564", "l": "carbazole 1,9a-dioxygenase activity", "d": ["Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634219", "l": "NUP93 recruits the Nup62 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47795", "l": "cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48755", "l": "2-oxoglutarate + O2 + validamycin A <=> CO2 + H(+) + succinate + validamycin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38890", "l": "H2O + N-hexanoyl-sphinganine <=> hexanoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.26", "l": "\"beta-fructofuranosidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186771", "l": "RNF111 binds SMAD7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53303", "l": "D-5-[2-(methylsulfanyl)ethyl]hydantoin + H2O <=> H(+) + N-carbamoyl-D-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22166", "l": "a globoside Forssman (d18:1(4E)) + H(+) + UDP => a globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14924", "l": "(indol-3-yl)acetate + UDP-alpha-D-glucose <=> 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980056", "l": "JAG1 binds NOTCH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69035", "l": "N,N-dihydroxy-L-aspartate <=> (2S)-2-nitrosobutanedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10088", "l": "sucrose + UDP-alpha-D-galactose = 6(F)-alpha-D-galactosylsucrose + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.167", "l": "\"sucrose 6(F)-alpha-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46577", "l": "H(+) + NADPH + O2 + sitosterol => 2 H2O + NADP(+) + stigmasterol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69951", "l": "3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28147", "l": "geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] => 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935766", "l": "miR-378 binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111879", "l": "PIP2 hydrolysis (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34982", "l": "H(+)(in) <=> H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11974", "l": "12 H(+) + 4 iron(III) oxide-hydroxide => 4 Fe(2+) + 6 H2O + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14687", "l": "AH2 + an aldehyde => A + a primary alcohol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54428", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O = ADP-D-ribose + H(+) + L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.25", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13525", "l": "(1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin] = (1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.1", "l": "\"camphor 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16182", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25775", "l": "2-oxoglutarate + L-asparagine + O2 <=> (2S,3S)-3-hydroxyasparagine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2404134", "l": "RBP4:atROL binds TTR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10693", "l": "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 => H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015056", "l": "corticotrophin-releasing factor receptor activity", "d": ["Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607753", "l": "CARD9 oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63448", "l": "(2-aminoethyl)phosphonate + CTP = CMP-(2-aminoethyl)phosphonate + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.107", "l": "\"(2-aminoethyl)phosphonate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46461", "l": "(22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12386", "l": "H2O2 + uracil => 5,6-dihydrouracil + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000433", "l": "SUMOylation of PML with SUMO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16502", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol => H(+) + myo-inositol + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48802", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+) => a neolactoside nLc4Cer + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11847", "l": "acetyl-CoA + formate <=> CoA + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36232", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655193", "l": "KIAA0101 double monoubiquitination (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11805", "l": "an aromatic aldehyde + H2O + NAD(+) => an aromatic carboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008043", "l": "MAPK8 phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61637", "l": "ATP + CoA + isophthalate => AMP + diphosphate + isophthalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53840", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADP(+) = 7,12-dioxo-lithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35123", "l": "H(+)(out) + L-alanyl-D-glutamate(out) = H(+)(in) + L-alanyl-D-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876472", "l": "NPC2 binds CHOL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28279", "l": "3-sulfino-L-alanine + H2O => H(+) + L-alanine + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17671", "l": "3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+) => 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12434", "l": "H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine => L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624624", "l": "FBXO32 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11701", "l": "H(+) + NADPH + O2 + progesterone => H2O + NADP(+) + testosterone acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166792", "l": "Conversion of C2 into C2a and C2b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070677", "l": "rRNA (cytosine-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781953", "l": "YOD1 binds VCP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33398", "l": "H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester <=> GMP + N(alpha)-acetyl-L-lysine methyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62325", "l": "(+)-malbrancheamide B + chloride + FAD + 2 H(+) => (+)-malbrancheamide + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68440", "l": "beta-cryptoxanthin + O2 = (3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418553", "l": "cAMP degradation by Phosphodiesterases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60188", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate", "d": [], "t": []}, {"i": "EC:1.14.11.65", "l": "\"[histone H3]-dimethyl-L-lysine(9) demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19108", "l": "4-aminobutanal + H2O + NAD(+) <=> 4-aminobutanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416929", "l": "PTGFR binds PGF2a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36642", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine <=> 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41273", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60351", "l": "N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36873", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA => (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990663", "l": "dihydroorotate dehydrogenase (fumarate) activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13066", "l": "ATP + H2O => ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-934604", "l": "Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682010", "l": "ATG10:ATG12 binds ATG5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5252001", "l": "ATP1B4 binds SNW1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10543", "l": "7,8-dihydroneopterin <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380586", "l": "loading of Serotonin in synaptic vesicles (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27831", "l": "neryl diphosphate => beta-phellandrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004140", "l": "dephospho-CoA kinase activity", "d": ["Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928619", "l": "PAK1 binds RAC1:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65798", "l": "1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17163", "l": "2-oxopent-4-enoate + benzoate + H(+) => 2,6-dioxo-6-phenylhexa-3-enoate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40659", "l": "1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12497", "l": "2 Fe(2+) + 4 H2O + O2 => 6 H(+) + H2O2 + 2 iron(III) oxide-hydroxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159253", "l": "MMAB adenosylates cob(I)alamin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32285", "l": "H(+) + H2O + quinolinate => 3-hydroxyanthranilate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60336", "l": "N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912627", "l": "CBL ubiquitinates PI3K (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532549", "l": "MPI isomerises Fru6P to Man6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11219", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ATP <=> a 2'-deoxyribonucleoside 5'-diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67751", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913370", "l": "Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76538", "l": "FAD(in) <=> FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783332", "l": "APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76596", "l": "a dicarboxylate(in) + sulfate(out) => a dicarboxylate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74232", "l": "H2O + L-threonyl-tRNA(Val) => L-threonine + tRNA(Val)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168053", "l": "Phosphorylated MAPKs phosphorylate ATF-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61713", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-N(delta)-methyl-L-arginine => 2 Fe(III)-[cytochrome b5] + H2O + N(delta)-methyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18054", "l": "H2O + paraoxon => 4-nitrophenol + diethylphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418872", "l": "Phosphorylation of FADK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47846", "l": "CO2 + diphosphate + thiamine phosphate => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74186", "l": "S-adenosyl-L-methionine + taxifolin <=> H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53551", "l": "prostaglandin J2 <=> Delta(12)-prostaglandin J2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9681616", "l": "AP2 binds chlorpromazine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26459", "l": "ethylnitronate + FMNH2 + O2 => acetaldehyde + FMN + 2 H(+) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59991", "l": "cyclohexane-1-carbonyl-CoA + NADP(+) <=> cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.10.1.-", "l": "\"Molybdenumtransferases or tungstentransferases with sulfide groups as acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839363", "l": "TGFBR3 phosphorylation by TGFBR2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48240", "l": "a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45097", "l": "(9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49953", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate => 5,10-dihydrophenazine 1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10231", "l": "citrate <=> cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44541", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797267", "l": "Expression of CD36 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72143", "l": "AH2 + GTP + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42958", "l": "5-methylcytidine(38) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(38) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372542", "l": "Loading of dopamine into synaptic veiscles (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428262", "l": "ACER3 hydrolyzes phytoceramide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43506", "l": "2,5-diformylfuran + H2O2 => 5-hydroxymethylfurfural + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654651", "l": "Activated FGFR4 binds FRS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031708", "l": "endothelin B receptor binding", "d": ["Binding to an endothelin B receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16419", "l": "H(+) + L-glutamate + NADH => (S)-1-pyrroline-5-carboxylate + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24450", "l": "monoglucosyl-enterobactin + UDP => enterobactin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382055", "l": "Grb7 binds to the active PDGF receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210300", "l": "Interaction of DAP12 and TREM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24134", "l": "UDP-alpha-D-galactofuranose => UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.3.1", "l": "\"citrate (Si)-synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917811", "l": "STEAP3,STEAP4 reduce Fe3+ to Fe2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21591", "l": "N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate <=> H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690740", "l": "CD22 binds B-cell receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72774", "l": "7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72009", "l": "succinate(out) + urate(in) => succinate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0141165", "l": "glucosinolate transmembrane transporter activity", "d": ["Enables the transfer of a glucosinolate across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62082", "l": "6-sulfo-D-glucono-1,5-lactone + H(+) + NADPH => D-glucose 6-sulfate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60235", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0046332", "l": "SMAD binding", "d": ["Binding to a SMAD signaling protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57138", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9854368", "l": "ROS,RNS oxidize ACO2:4Fe-4S (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5604929", "l": "Activated protein C binds Protein S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9717841", "l": "holo-FDPS dimer binds NBPs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75594", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate <=> (11S)-hydroxy-(9S,10S)-epoxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30525", "l": "GDP + H(+) + oxidized coenzyme F420-2 + phosphate => GTP + L-glutamate + oxidized coenzyme F420-1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60000", "l": "hydroxymethylphosphonate + O2 = formate + 2 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:1.13.11.89", "l": "\"(hydroxymethyl)phosphonate dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71708", "l": "H(+)(out) + L-phenylalanyl-L-phenylalanine(out) => H(+)(in) + L-phenylalanyl-L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001647", "l": "G protein-coupled cytokinin receptor activity", "d": ["Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29933", "l": "ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59128", "l": "(S)-2,3-diaminopropanoate + 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + ATP = 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.3.2.55", "l": "\"2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31753", "l": "7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13321", "l": "(R)-3,3-dimethylmalate + NAD(+) = 3-methyl-2-oxobutanoate + CO2 + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.84", "l": "\"dimethylmalate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9648888", "l": "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59203", "l": "ATP + docosanoate + H(+) <=> diphosphate + docosanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78652", "l": "ATP + S-disulfanyl-L-cysteine + tRNA(Cys) => (S)-disulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9706837", "l": "AR binds AR antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20308", "l": "4-hydroxybenzaldehyde + H2O + NAD(+) <=> 4-hydroxybenzoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869683", "l": "oxPL binds LBP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65704", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose = alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11726", "l": "3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol => [thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47095", "l": "(S)-2,3-dihydrodipicolinate + NADP(+) <=> dipicolinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090438", "l": "camelliol C synthase activity", "d": ["Catalyzes the reaction: (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25690", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.67", "l": "\"CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794569", "l": "Apical transport of Cipro to extracellular space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709831", "l": "HSP90 binds TBK1 and IRF3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61110", "l": "(2R,3R)-dihydromyricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydrokaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634850", "l": "NPAS4 binds ARNT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851866", "l": "MET binds RANBP10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1467466", "l": "ABCA4 mediates atRAL transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803890", "l": "SFN dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47872", "l": "a ganglioside GM1 + H2O = a ganglioside GA1 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47894", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32207", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate = (3Z)-2-oxohex-3-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31821", "l": "5-epi-alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432537", "l": "PP2A dephosphorylates phosphorylated CLK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854981", "l": "SHC1 in the RET complex is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202969", "l": "Caspase mediated cleavage of beta-catenin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17760", "l": "H(+) + L-methionine <=> 3-(methylsulfanyl)propanamine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114256", "l": "CYCS:APAF1 binds procaspase-9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11582", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030785", "l": "[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11464", "l": "2 glutathione + L,L-homocystine = glutathione disulfide + 2 L-homocysteine", "d": [], "t": []}, {"i": "EC:1.8.4.1", "l": "\"glutathione--homocystine transhydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757459", "l": "ST metabolites diffuse out of ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29839", "l": "L-idonate + NADP(+) = 2-dehydro-L-idonate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432164", "l": "Ca2+ influx into the post-synaptic cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44920", "l": "(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H(+) + NADPH = (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805546", "l": "Keratin type I binds keratin type II (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70091", "l": "ethanol + o-quinone methide = hydroxyclavatol ethyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34084", "l": "a (3R)-3-hydroxyacyl-CoA => a (3S)-3-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333671", "l": "CLCAs self cleave (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691621", "l": "C5 binds C5 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001065", "l": "mannan binding", "d": ["Binding to mannan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086410", "l": "CDK1 phosphorylates BORA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60571", "l": "N-acetyl-L-tryptophan <=> N-acetyl-D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418845", "l": "Activation of caspase-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42664", "l": "alpha-L-arabinopyanose + NADP(+) = H(+) + L-arabinono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869558", "l": "HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20454", "l": "scopoletin + UDP-alpha-D-glucose => H(+) + scopolin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23550", "l": "H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine => guanosine(966) in 16S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54394", "l": "(9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75278", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate <=> (10R,11R)-epoxy-(9S)-hydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15976", "l": "3'-phosphoadenylyl sulfate + estrone <=> adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082391", "l": "Trimerization of HSF1 in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28883", "l": "H(+)(in) + L-threonine(in) = H(+)(out) + L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17245", "l": "3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2", "d": [], "t": []}, {"i": "EC:1.10.3.5", "l": "\"3-hydroxyanthranilate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75463", "l": "choline(out) + n H(+)(in) = choline(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507869", "l": "Aquaporins passively transport glycerol into cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32829", "l": "ADP + H(+) + methionine(in) + phosphate => ATP + H2O + methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904931", "l": "MCM complex binding", "d": ["Binding to an MCM complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851988", "l": "BTN2A2 binds T cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19725", "l": "H(+) + UDP-alpha-D-galacturonate = CO2 + UDP-beta-L-arabinopyranose", "d": [], "t": []}, {"i": "EC:4.1.1.67", "l": "\"UDP-galacturonate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68988", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140757", "l": "cysteine-type deNEDDylase activity", "d": ["An thiol-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30321", "l": "7-methylxanthine + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5615668", "l": "AKR1C3 reduces atRAL to atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0042799", "l": "histone H4K20 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6791016", "l": "SFTPB binds itself (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25417", "l": "AH2 + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54650", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => ent-8alpha-hydroxylabd-13-en-15-yl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034842", "l": "thiophene-2-carboxylate-CoA ligase activity", "d": ["Catalysis of the reaction: thiophene-2-carboxylate + ATP + CoASH = thiophene-2-carboxyl-CoA + AMP + PPi."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78008", "l": "a 1,2-diacyl-3-(9Z,12Z-octadecadienoyl)-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine => a 1,2-diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68706", "l": "3alpha-hydroxyetiocholan-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3alpha-hydroxyetiocholan-17-one 3-O-(beta-D-glucuronate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5140741", "l": "WNT5A binds FZD and ROR receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000225", "l": "N-acetylglucosaminylphosphatidylinositol deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71459", "l": "H2O + substance P = L-Leu-L-Met-NH2 + substance P(1-9)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47854", "l": "a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55739", "l": "alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose <=> [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18194", "l": "H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] => (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761170", "l": "Expression of PAX2 in intermediate mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71139", "l": "acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH = 3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64985", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43974", "l": "H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol) => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73093", "l": "AMP(in) + FMN(out) => AMP(out) + FMN(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59691", "l": "D-maltoheptaose + O2 <=> D-maltoheptaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30552", "l": "acetyl-CoA + beta-D-glucose => 6-O-acetyl-beta-D-glucose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37069", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.943550433440578", "identifiers": [{"i": "GO:0061659", "l": "ubiquitin-like protein ligase activity", "d": ["Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785607", "l": "FANCM binds FAAP24 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37326", "l": "glycyl-L-methionine + H2O <=> glycine + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34555", "l": "a (2S)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156930", "l": "GTP-binding activates eEF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-203774", "l": "Interaction of Csk with PAG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9854672", "l": "FAD attaches to SDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004640", "l": "phosphoribosylanthranilate isomerase activity", "d": ["Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0015141", "l": "succinate transmembrane transporter activity", "d": ["Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61949", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9861563", "l": "CTLH E3 ligase ubiquitinates LDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18205", "l": "AH2 + O2 + progesterone = 11alpha-hydroxyprogesterone + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.14", "l": "\"progesterone 11alpha-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47347", "l": "7-oxocholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,26-dihydroxycholest-5-en-7-one + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52983", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13880", "l": "a 2-oxocarboxylate + L-ornithine <=> an L-alpha-amino acid + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39253", "l": "(11Z)-eicosenoyl-CoA + NADP(+) => (2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56350", "l": "2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+) => 4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-874087", "l": "SGT1 binds HSP90 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17864", "l": "21-hydroxyprogesterone <=> 20-hydroxy-3-oxopregn-4-en-21-al", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213244", "l": "Loading of antigenic peptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52862", "l": "a short-chain fatty acyl-CoA + AMP + diphosphate => a short-chain fatty acid + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706298", "l": "Active FLT3 binds to CSK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.20.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47996", "l": "1,6-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41065", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34773", "l": "a 3-oxosteroid + CO2 + NADPH => a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33863", "l": "menaquinone-7 + succinate = fumarate + menaquinol-7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163310", "l": "TFAM binds to mitochondrial promoters (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047504", "l": "(-)-menthol dehydrogenase activity", "d": ["Catalysis of the reaction: (-)-menthol + NADP+ = (2S,5R)-menthone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29434", "l": "ATP + phosphate <=> ADP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77784", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)glycine + O2 => 2-dehydro-D-glucose + glycine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9017817", "l": "Gamma-secretase cleaves YBX1:NOTCH3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46134", "l": "25-hydroxycholesterol + H2O + NADP(+) => cholesterol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25864", "l": "H2O + N(1)-acetylspermidine + O2 = 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39007", "l": "a cholesterol ester(in) = a cholesterol ester(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35418", "l": "an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose <=> an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57703", "l": "a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40547", "l": "10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65598", "l": "4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74981", "l": "(3R)-3-isocyanylbutanoyl-AMP + diphosphate => (3R)-3-isocyanylbutanoate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33591", "l": "sphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216043", "l": "Collagen type II binds integrin alpha10beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56894", "l": "NADP(+) + UDP-beta-L-rhamnose => H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11950", "l": "4-hydroxybenzoate + CoA + H(+) => 4-hydroxybenzoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005046", "l": "KDEL sequence binding", "d": ["Binding to a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67796", "l": "a ribonucleotidyl-ribonucleotide-RNA = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050461", "l": "L-mimosine synthase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridinium-1-yl)-L-alanine + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0098633", "l": "collagen fibril binding", "d": ["Binding to a collagen fibril."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102238", "l": "geraniol kinase activity (ATP-dependent) activity", "d": ["Catalysis of the reaction: geraniol + ATP = geranyl monophosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58078", "l": "(11Z)-eicosenoate + glycerol + H(+) => 1-(11Z-eicosenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209168", "l": "Phosphorylation of SMO by CKIalpha (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14115", "l": "a 3'-end 2'-deoxyribonucleotide-DNA + phosphate => a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013143", "l": "RAC1 GEFs activate RAC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036209", "l": "9beta-pimara-7,15-diene oxidase activity", "d": ["Catalysis of the reaction: 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72158", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) <=> 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373748", "l": "SEMA4D interacts with CD72 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45285", "l": "eicosanoyl-CoA + sphing-4-enine => CoA + H(+) + N-eicosanoyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56870", "l": "(2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA => (2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13683", "l": "a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine => a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65477", "l": "1-propanol + butanoyl-CoA => CoA + propyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44337", "l": "an L-alpha-amino acid + ATP + L-arginine => ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70545", "l": "3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36153", "l": "(E)-cinnamyl acetate + CoA => (E)-cinnamyl alcohol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22502", "l": "(E)-feruloylacetyl-CoA + CO2 + CoA => (E)-feruloyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047911", "l": "galacturan 1,4-alpha-galacturonidase activity", "d": ["Catalysis of the reaction: [(1->4)-alpha-D-galacturonide](n) + H2O = [(1->4)-alpha-D-galacturonide](n-1) + D-galacturonate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15479", "l": "5beta-scymnol sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 5beta-scymnol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35172", "l": "H(+)(out) + novobiocin(in) => H(+)(in) + novobiocin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14006", "l": "H2O + L,L-cystathionine => 2-oxobutanoate + L-cysteine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389350", "l": "Activation of Cdc42 by pVav1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62045", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O => (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975633", "l": "atROL binds to RBP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373747", "l": "Phosphorylation of nephrin by FYN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58701", "l": "FADH2-C4alpha-hydroperoxide + NADPH + rifampicin => FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016807", "l": "cysteine-type carboxypeptidase activity", "d": ["Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382057", "l": "Release of novel PDGFs as latent factors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10879", "l": "4-hydroxybenzoate + H(+) <=> CO2 + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9843993", "l": "me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1 RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852362", "l": "GTSE1 binds CDKN1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78996", "l": "a 3-carboxymethyl-3-hydroxyacyl-[ACP] => a 4-carboxy-3-alkylbut-(2E)-enoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48648", "l": "lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50665", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8941895", "l": "Formation of CDK4/6:CCND complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3797196", "l": "AP-1 transcription factor binds IGFBP7 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809680", "l": "MTMR12 binds MTM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3965450", "l": "DAAM1 recruits PFN1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76379", "l": "n H(+)(out) + L-histidine(out) = n H(+)(in) + L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592278", "l": "Autocatalytic activation of proMMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72565", "l": "butanoate(in) + dehydroepiandrosterone 3-sulfate(out) => butanoate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1235070", "l": "Expression of Erythropoietin (EPO) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23709", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54895", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide <=> [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418904", "l": "A1 and A3 receptors bind adenosine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28538", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56990", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75368", "l": "cytidine(in) => cytidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77704", "l": "a ganglioside GA1 (d18:1(4E)) + GDP-beta-L-fucose => a ganglioside Fuc-GA1 (d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62988", "l": "dodecanamide + H2O = dodecanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008518", "l": "folate:monoatomic anion antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF."], "t": []}, {"i": "TCDB:2.A.48", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3341294", "l": "Superoxide reduces cytochrome c (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170026", "l": "UCP1 imports a proton (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54523", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> cycloaraneosene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0045309", "l": "protein phosphorylated amino acid binding", "d": ["Binding to a phosphorylated amino acid residue within a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51861", "l": "(2E)-geranyl diphosphate + umbelliferone => 8-geranylumbelliferone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18480", "l": "2,3-dihydroxybenzoate + O2 <=> 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44992", "l": "(R)-carnitine + 2-methylbutanoyl-CoA = CoA + O-2-methylbutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52226", "l": "3 A + biliverdin IXdelta + CO + Fe(2+) + 3 H2O => 3 AH2 + 3 H(+) + heme b + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30782", "l": "D-gluconate + FAD + H(+) <=> 2-dehydro-D-gluconate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168136", "l": "Activated JNKs phosphorylate c-JUN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647680", "l": "CASP1 cleaves GSDMD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34695", "l": "(2E,6E)-farnesyl diphosphate = Delta(6)-protoilludene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.135", "l": "\"Delta(6)-protoilludene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16651", "l": "(S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67129", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH => (1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008755", "l": "O antigen polymerase activity", "d": ["Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856510", "l": "STARD7 transports Q10 to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65821", "l": "decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197972", "l": "DHF is reduced to tetrahydrofolate (THF) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71213", "l": "chlorate(in) + 2 Na(+)(in) => chlorate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015478", "l": "oligosaccharide transporting porin activity", "d": ["Enables the transfer of oligosaccharide, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693540", "l": "MRN activates ATM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72765", "l": "anthocyanin A11 + CoA => anthocyanin A10 + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66323", "l": "2',3'-cGAMP(out) <=> 2',3'-cGAMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13586", "l": "ATP + butanoate => ADP + butanoyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199558", "l": "KIR2DL1 interacting with HLA-C group 2 (Cw3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56401", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47980", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015086", "l": "cadmium ion transmembrane transporter activity", "d": ["Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10750", "l": "CO2 + H2O => H(+) + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944262", "l": "Association of procollagen type X (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30333", "l": "all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109857", "l": "MAP2K1 binds MAPK3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015513", "l": "high-affinity secondary active nitrite transmembrane transporter activity", "d": ["Catalysis of the transfer of nitrite from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140862", "l": "histone H2AK119 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-119 residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72909", "l": "D-mannose(in) + Na(+)(in) => D-mannose(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65824", "l": "dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12438", "l": "CoA + H(+) + N-caffeoylputrescine => (E)-caffeoyl-CoA + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66647", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + trichobrasilenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404135", "l": "RBP4 binds atROL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40909", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68282", "l": "CoA + O-pentanoyl-L-seryl-[protein] => L-seryl-[protein] + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9853372", "l": "FIRRM binds PPP1CC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22244", "l": "kaempferol + UDP-alpha-D-xylose = H(+) + kaempferol 3-O-beta-D-xyloside + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.56", "l": "\"kaempferol 3-O-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043892", "l": "methylglyoxal reductase (NADPH) activity", "d": ["Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26080", "l": "methanesulfonate + NADH + O2 <=> formaldehyde + H2O + NAD(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102921", "l": "mannosylglycerate synthase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose + D-glycerate = H+ + 2-(alpha-D-mannosyl)-D-glycerate + GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77952", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate => 1-(9Z-octadecenoyl)-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78663", "l": "gamma-lactone-2-keto[5.5.5.5]fenestrane + H(+) + NADPH + O2 = H2O + NADP(+) + penifulvin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12212", "l": "9H-fluoren-9-ol + NADP(+) = 9H-fluoren-9-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050389", "l": "uronolactonase activity", "d": ["Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050214", "l": "progesterone monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + O2 + progesterone = A + H2O + testosterone acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052662", "l": "zeaxanthin epoxidase activity", "d": ["Catalysis of the reaction: all-trans-zeaxanthin + 4 H+ + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21609", "l": "isoliquiritigenin + S-adenosyl-L-methionine => 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800035", "l": "IGFBP3 binds TMEM219 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27991", "l": "1-deoxy-D-xylulose + ATP => 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72835", "l": "3',3'-cUAMP + H2O = H(+) + U[3'-5']pAp[3']", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21897", "l": "(R)-1-aminopropan-2-yl phosphate + adenosylcob(III)yrate + ATP => adenosylcob(III)inamide phosphate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53330", "l": "2,3-diacyl-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP => H2O + UDP-2,3-diacyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731123", "l": "Syndecan-1 binds Integrin alphaVbeta3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602885", "l": "Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15914", "l": "ATP + thiamine phosphate => ADP + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22643", "l": "NADP(+) + sphinganine <=> 3-oxosphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60233", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65548", "l": "a ganglioside Fuc-GM1 + H2O = alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9644900", "l": "BDNF gene expression is stimulated by NPAS4:ARNT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54760", "l": "ATP + H(+) + pyridinium-3,5-dicarboxylate mononucleotide = 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592362", "l": "Activation of proMMP7 by MMP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380203", "l": "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912410", "l": "NOTCH4 mRNA translation controlled by miRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193508", "l": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59989", "l": "cyclohexane-1-carbonyl-CoA + NADP(+) => cyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.47", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72729", "l": "UDP-alpha-D-glucuronate(out) + UMP(in) => UDP-alpha-D-glucuronate(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39415", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH = (21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78286", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> (-)-somaliensene B + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45759", "l": "(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825842", "l": "MITF-M dimer binds the PMEL gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9858590", "l": "DLST transfers glutaryl to CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981539", "l": "C3b binds to cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16199", "l": "acetoacetyl-CoA + H(+) + NADPH => (3S)-3-hydroxybutanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604360", "l": "Initial activation of proMMP2 by MMP14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679239", "l": "ULK complex translocates to the ER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76104", "l": "(11R)-carlactonoate + S-adenosyl-L-methionine => (11R)-methyl carlactonoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39482", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH <=> (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34631", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.15", "l": "\"cholestanetriol 26-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032399", "l": "HECT domain binding", "d": ["Binding to a HECT, 'Homologous to the E6-AP Carboxy-Terminus', domain of a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71117", "l": "3-hydroxyhispidin + H2O + NAD(+) => H(+) + hispidin + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62476", "l": "3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690023", "l": "NUBPL binds 4Fe-4S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13456", "l": "3'-phosphoadenylyl sulfate + quercetin <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30923", "l": "(R)-glycerate + ADP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.268", "l": "\"glucosylglycerate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37748", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-octadecyl-sn-glycero-3-phosphocholine => 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047184", "l": "1-acylglycerophosphocholine O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0004096", "l": "catalase activity", "d": ["Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482679", "l": "PA is hydrolysed to 1-acyl LPA by PLA2G2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77821", "l": "2-dehydro-D-glucose + H2O2 + L-alanine => H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-alanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53611", "l": "4-hydroxyestrone + O2 <=> (2Z,10Z)-3-hydroxy-5,17-dioxo-4,5-secoestra-2,10-diene-3-oate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29211", "l": "H(+)(out) + inosine(in) = H(+)(in) + inosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22401", "l": "androstan-3alpha,17beta-diol + NAD(+) => 17beta-hydroxyandrostanone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63560", "l": "angiotensin I + H2O = angiotensin II + L-histidyl-L-leucine", "d": [], "t": []}, {"i": "EC:3.4.15.1", "l": "\"peptidyl-dipeptidase A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183067", "l": "Localization of CBL:GRB2 to the membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676595", "l": "TRAFs bind RANK:RANKL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730862", "l": "Autophosphorylation of LYN kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56423", "l": "apo-[D-alanyl-carrier protein] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052719", "l": "RNA-(apurinic or apyrimidinic site) endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a ribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-ribose phosphate and 3'-hydroxyl ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35848", "l": "ATP + sphing-4-enine => ADP + H(+) + sphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25714", "l": "L-trihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031964", "l": "beta-alanyl-histamine hydrolase activity", "d": ["Catalysis of the reaction: N-beta-alanyl histamine + H2O = histamine + beta-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3204303", "l": "MRE11 binds cytosolic DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937814", "l": "RUNX3 translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44866", "l": "a 1,2-diacylglycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25107", "l": "ATP + pyridoxamine <=> ADP + H(+) + pyridoxamine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102562", "l": "hydroxyproline O-arbinofuranose transferase activity", "d": ["Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline = UDP + H+ + a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28952", "l": "H(+)(in) + L-arabinose(in) => H(+)(out) + L-arabinose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34033", "l": "acetate + paromamine => 2'-N-acetylparomamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70559", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69497", "l": "decan-1-ol + O2 => decanal + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166038", "l": "GPI-bound CD14 binds LPS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866269", "l": "ARRB bind GPCRs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018738", "l": "S-formylglutathione hydrolase activity", "d": ["Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77724", "l": "a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose => a neolactoside V(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875661", "l": "GGA3 associates with activated MET receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77571", "l": "a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162187", "l": "COQ6 hydroxylates DHB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032866", "l": "D-xylose reductase (NADPH) activity", "d": ["Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917696", "l": "Cargo Sequestration (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562541", "l": "TLR4-induced ripoptosome assembly (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374692", "l": "Neogenin binds repulsive guidance molecules (RGDs) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52906", "l": "ADP + coenzyme F430 + phosphate => 15,17(3)-seco-F430-17(3)-acid + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27843", "l": "9H-carbazole + H(+) + NADPH + O2 => 2'-aminobiphenyl-2,3-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42200", "l": "corticosterone + NADP(+) = 11-dehydrocorticosterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16806", "l": "2-oxoglutarate + deacetoxycephalosporin C + O2 => CO2 + deacetylcephalosporin C + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67658", "l": "2 Fe(II)-[cytochrome c] + H(+) + NADP(+) => 2 Fe(III)-[cytochrome c] + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31516", "l": "4'-apo-beta-carotenal + H2O + NAD(+) => 2 H(+) + NADH + neurosporaxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444202", "l": "Receptor FFAR1 binds free fatty acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71303", "l": "RPE dimers isomerise RU5P to XY5P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42645", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] => diphosphate + holo-[malonate decarboxylase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141431", "l": "MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112395", "l": "Abortive termination of elongation after arrest (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140761", "l": "sequestered tissue factor -> tissue factor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.71648590403835", "identifiers": [{"i": "GO:0016670", "l": "oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen."], "t": []}, {"i": "EC:1.8.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73773", "l": "H(+) + 2 H2O + neoechinulin A + oxidized [NADPH--hemoprotein reductase] => O2 + preechinulin + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22826", "l": "2-deoxy-alpha-D-ribose 1-phosphate + uracil => 2'-deoxyuridine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036463", "l": "TRAIL receptor activity", "d": ["Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic cell death."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112042", "l": "Opioid binds MOR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49338", "l": "H2O + spheroiden-2-one => 2,2-dihydroxyspheroidene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797554", "l": "ABP1 binds SHANK proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669240", "l": "FLNA binds PAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0016898", "l": "oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule."], "t": []}, {"i": "EC:1.1.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32225", "l": "AMP + H(+) + NADH + phosphate => (6S)-NADHX + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9639286", "l": "RRAGC,D exchanges GTP for GDP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78858", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + O2 <=> a medium-chain (2E)-enoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.-", "l": "\"Sulfotransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16917", "l": "2,6-dihydroxypyridine + H(+) + NADH + O2 = 2,3,6-trihydroxypyridine + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.10", "l": "\"2,6-dihydroxypyridine 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37170", "l": "(2E,6E)-farnesol + NAD(+) <=> (2E,6E)-farnesal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6805811", "l": "Release of SEPT4 from mitochondria (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73975", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.49", "l": "\"omptin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202500", "l": "Activation of IKK complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24342", "l": "(R)-acetoin + H(+) + NADH => (R,R)-butane-2,3-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047839", "l": "dATP(dGTP)-DNA purinetransferase activity", "d": ["Catalysis of the reaction: dATP + depurinated DNA = ribose triphosphate + DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25684", "l": "2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] => L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027598", "l": "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19979", "l": "adenosine 3',5'-bisphosphate + H(+) + L-tyrosine methyl ester 4-sulfate => 3'-phosphoadenylyl sulfate + L-tyrosine methyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21293", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56867", "l": "12 H(+) + 6 malonyl-CoA + NADH + 5 NADPH <=> (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + 6 CoA + 4 H2O + NAD(+) + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683879", "l": "SFTPA genes produce SFTPA proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706287", "l": "Active FLT3 binds to ABL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29039", "l": "ATP + H2O + L-aspartate(out) = ADP + H(+) + L-aspartate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708408", "l": "DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53914", "l": "CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein] => butanoyl-CoA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416530", "l": "FFAR1:FFAR1 ligands activate Gq (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.164", "l": "\"galactan endo-1,6-beta-galactosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58354", "l": "CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695415", "l": "glycosylated-ACE2 binds ACE2 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868071", "l": "Clathrin recruits PIK3C2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61512", "l": "malvidin + UDP-alpha-D-glucose = malvidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54807", "l": "2 4-sulfanylbutanoate + NAD(+) <=> 4,4'-disulfanyldibutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0004875", "l": "complement receptor activity", "d": ["Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047845", "l": "deoxylimonate A-ring-lactonase activity", "d": ["Catalysis of the reaction: deoxylimonoate + H2O = deoxylimononate D-ring-lactone + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106438", "l": "protein-glutamic acid ligase activity, elongating", "d": ["Catalytic reaction :(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl-[protein] + ADP + H+ + phosphate."], "t": []}, {"i": "RHEA:60148", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate = (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626228", "l": "The distal appendage proteins recruit TTBK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67402", "l": "allo-aromadendrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419351", "l": "PAF receptor binds platelet activating factor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.3", "l": "\"metridin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51562", "l": "(S)-N-methylbulbocapnine + H(+) + S-adenosyl-L-homocysteine => (S)-bulbocapnine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64565", "l": "8-epi-ilicicolin H => ilicicolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37551", "l": "3-dehydro-D-glucose 6-phosphate + L-glutamate = 2-oxoglutarate + D-kanosamine 6-phosphate", "d": [], "t": []}, {"i": "EC:2.6.1.104", "l": "\"3-dehydro-glucose-6-phosphate--glutamate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665982", "l": "RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004028", "l": "3-chloroallyl aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047951", "l": "glutathione thiolesterase activity", "d": ["Catalysis of the reaction: S-acylglutathione + H2O = a carboxylate + glutathione + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21423", "l": "NADP(+) + prostaglandin I2 <=> 15-dehydro-prostaglandin I2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49369", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+) => 19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65930", "l": "3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine => 3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15873", "l": "[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.242", "l": "\"NDP-glucose--starch glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4719436", "l": "PIAS2,3,4 SUMOylate RORA with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179421", "l": "Degradation of multiubiquitinated Nek2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072571", "l": "mono-ADP-D-ribose binding", "d": ["Binding to monomeric ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-844447", "l": "NLRP1 senses MDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44296", "l": "2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA = 4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19351", "l": "(R)-3,3-dimethylmalate + 2 H(+) + NADH => (R)-4-dehydropantoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9650473", "l": "SERPING1 is secreted (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63812", "l": "ATP + N(8)-citryl-spermidine + spermidine = AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34231", "l": "5-nitrosalicylate + O2 = 4-nitro-6-oxohepta-2,4-dienedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52603", "l": "L-methionine + propanoyl-CoA <=> CoA + H(+) + N-propanoyl-L-methioninate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046405", "l": "glycerol dehydratase activity", "d": ["Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67974", "l": "ADP + ecdysone 22-phosphate + H(+) => ATP + ecdysone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58255", "l": "H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] <=> ADP-D-ribose + L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59462", "l": "H(+) + hexadecanal + NADPH => hexadecan-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102978", "l": "furaneol oxidoreductase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2,5-dimethylfuran-3-one + NADP = 4-hydroxy-5-methyl-2-methylenefuran-3-one + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169461", "l": "MCM8 mediated fork unwinding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58621", "l": "N-decanoyl-(2S)-hydroxyglycine => decanamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25013", "l": "H(+) + N,N-dihydroxy-L-tryptophan = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2997706", "l": "MDM2 SUMOylates TP53 with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26174", "l": "CoA + H(+) + mycothiol => 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212642", "l": "L-Glutamine transport into neurons (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193695", "l": "IRAK interacts with TRAF6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209179", "l": "IAP2:BEN:UEV1A E3 ligase complex auto-ubiquitinates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.102", "l": "\"phenacrylate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30838", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18668", "l": "(2R)-3-phospho-glyceroyl phosphate + [phosphate](n) <=> (2R)-3-phosphoglycerate + [phosphate](n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021357", "l": "PRKCI phosphorylates ELF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78054", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1-O-alkyl-2-acetyl-3-acylglycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56120", "l": "2-all-trans-heptaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10111", "l": "(7S)-salutaridinol + NADP(+) <=> H(+) + NADPH + salutaridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612255", "l": "ERBB4s80 binds ADAP1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18488", "l": "6-acetyl-D-glucose + H2O <=> acetate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034933", "l": "1-hydroxy-6-methoxypyrene methyltransferase activity", "d": ["Catalysis of the reaction: 1-hydroxy-6-methoxypyrene + XCH3 = 1,6-dimethoxypyrene + HX."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57923", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) <=> H(+) + L-asparaginyl-tRNA(Asn) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53528", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2172678", "l": "PHF8 demethylates histone H4K20me1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72856", "l": "ADP(out) + dADP(in) => ADP(in) + dADP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33530", "l": "acetyl-CoA + ergosta-5,7,22,24(28)-tetraen-3beta-ol <=> CoA + ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9646685", "l": "Aggresome dissociates from dynein and microtubule (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102676", "l": "avenasterol-desaturase activity", "d": ["Catalysis of the reaction: avenasterol + O2 + NADPH + H+ = 5-dehydroavenasterol + 2 H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848713", "l": "PTK6 binds BCAR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54504", "l": "all-trans-hexaprenyl diphosphate = beta-hexaprene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48847", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78184", "l": "a 1,2-diacylglycerol + an acyl-CoA => a triacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9692867", "l": "HRH3 binds pitosilant (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5333678", "l": "CPNEs bind PL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47531", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isocholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948775", "l": "MKRN1 polyubiquitinates PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2152276", "l": "Secretion of transmembrane collagens (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40880", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.13", "l": "\"2-halobenzoate 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54525", "l": "acetoacetate + H(+) + methylglyoxal => 3-hydroxyhexane-2,5-dione + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047750", "l": "cholestenol delta-isomerase activity", "d": ["Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18601", "l": "3,4-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.69", "l": "\"3,4-dihydroxyphthalate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654167", "l": "Activated FGFR1 binds PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2248891", "l": "M6PR transports activated ARSA to the lysosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709406", "l": "CO binds to Cytochrome c oxidase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432464", "l": "Phosphorylated TIM:PER heterodimer dissociate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54627", "l": "2-oxoglutarate + O2 + octadecanoyl-CoA <=> 2-hydroxyoctadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008894", "l": "guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity", "d": ["Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047990", "l": "hydroxyglutamate decarboxylase activity", "d": ["Catalysis of the reaction: 3-hydroxy-L-glutamate + H+ = 4-amino-3-hydroxybutanoate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46976", "l": "(S)-6-hydroxynicotine + O2 = 6-hydroxy-N-methylmyosmine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9858589", "l": "DLD dimer dehydrogenates dihydrolipoyl (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51409", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58717", "l": "FADH2-C4alpha-hydroperoxide + NADH + rifampicin => FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32906", "l": "calciol + O2 + reduced [NADPH--hemoprotein reductase] <=> calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840408", "l": "OMA1 cleaves DELE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34047", "l": "6'''-deamino-6'''-hydroxyneomycin C + O2 = 6'''-deamino-6'''-oxoneomycin C + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.44", "l": "\"6'''-hydroxyneomycin C oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508282", "l": "SYK is a substrate for JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210773", "l": "PDX1-dependent synthesis of NR5A2 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13657", "l": "acetyl-[citrate lyase ACP] + H2O = acetate + H(+) + holo-[citrate lyase ACP]", "d": [], "t": []}, {"i": "EC:3.1.2.16", "l": "\"citrate-lyase deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68276", "l": "butanoyl-CoA + L-seryl-[protein] = CoA + O-butanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874979", "l": "ACBD3 binds GOLGB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031737", "l": "CX3C chemokine receptor binding", "d": ["Binding to a CX3C chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77578", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecylglycerol <=> 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38520", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41444", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + 2 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:1.13.11.78", "l": "\"2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52808", "l": "adenosine in U6 snRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.346", "l": "\"U6 snRNA m(6)A methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675206", "l": "PEA15 binds MAPK monomers and dimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28493", "l": "H(+)(in) + K(+)(in) <=> H(+)(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53397", "l": "a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] => 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102462", "l": "quercetin 3-sophoroside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose = quercetin 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34256", "l": "sporulenol => (R)-tetraprenyl-beta-curcumene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700171", "l": "Active ALK phosphorylates PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75081", "l": "Formation of AT-AC B Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9859163", "l": "DBT transfers BCAA to CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27929", "l": "UMP(in) <=> UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160044", "l": "sulfate:chloride antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + sulfate(out) = chloride(out) + sulfate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72067", "l": "(2S)-2-aminobutanoate + ATP + L-glutamate = ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10991", "l": "H2O + nitrous oxide <=> 2 e(-) + 2 H(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47549", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oate => 3-oxochola-4,6-dien-24-oate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444476", "l": "FPRL2 receptor binds a wide range of ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.8", "l": "\"capsanthin/capsorubin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29026", "l": "H(+)(in) + L-fucose(in) <=> H(+)(out) + L-fucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24711", "l": "2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose => L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840579", "l": "GM1 localizes to ILV membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67676", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71555", "l": "5-C(alpha)-glycyl-dTMP in DNA + H(+) = 5-aminoethyl-dUMP in DNA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247497", "l": "ERBB3 binds neuregulins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63924", "l": "ATP + N(4)-acetylcytidine = ADP + H(+) + N(4)-acetylcytidine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.124", "l": "\"protein deglycase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64174", "l": "galactarate => L-altrarate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49865", "l": "(+)-dehydrodiconiferyl acid + 2 a quinone + H2O => (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560804", "l": "Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686657", "l": "ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211874", "l": "CYP2S1 4-hydroxylates atRA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70446", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2 <=> a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612996", "l": "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63703", "l": "mycophenolate + UDP-alpha-D-glucuronate <=> mycophenolic acid O-acyl-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33246", "l": "L-tetrahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-7-(methylsulfanyl)heptanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42807", "l": "5,6,7,8-tetrahydromethanopterin + A <=> 7,8-dihydromethanopterin + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26064", "l": "ATP + hygromycin B = 4-O-phosphohygromycin B + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.163", "l": "\"hygromycin B 4-O-kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373075", "l": "Metabotropic glutamate receptors bind glutamate (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31588", "l": "FMNH2 + NADH + O2 + uracil => (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38243", "l": "(9Z)-octadecenoyl-CoA + eicosan-1-ol = 1-O-eicosanyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35407", "l": "H2O + medicarpin = 4'-methoxyisoflavan-2',4,7-triol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62792", "l": "3 H(+) + NADPH + O2 + 2 rubrofusarin B = 2 H2O + NADP(+) + nigerone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59337", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene + A => AH2 + demethylspheroidene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75990", "l": "a dicarboxylate(in) + indoxyl sulfate(out) <=> a dicarboxylate(out) + indoxyl sulfate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730892", "l": "Recruitment of VAV to p-SLP-76 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1504213", "l": "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59631", "l": "H2O + N(2)-(4-aminobutanoyl)-L-arginine <=> 4-aminobutanoate + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53806", "l": "allodeoxycholate + ursodeoxycholoyl-CoA => allodeoxycholoyl-CoA + ursodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68931", "l": "ATP + H(+) + heptanoate + NADPH <=> AMP + diphosphate + heptanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39881", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a 2,3-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112434", "l": "Formation of DSIF complex  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45588", "l": "a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.20", "l": "\"long-chain-fatty-acid--[acyl-carrier-protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004643", "l": "phosphoribosylaminoimidazolecarboxamide formyltransferase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48556", "l": "4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate", "d": [], "t": []}, {"i": "EC:2.4.2.54", "l": "\"beta-ribofuranosylphenol 5'-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68027", "l": "H2O + presqualene phosphate <=> phosphate + presqualene alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.1.22", "l": "\"4-hydroxyproline betaine 2-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34482", "l": "(1R,2R,3R)-prephytoene diphosphate <=> 15-cis-phytoene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43962", "l": "a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035373", "l": "chondroitin sulfate proteoglycan binding", "d": ["Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9838289", "l": "CLPXP degrades mitochondrial matrix proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790987", "l": "NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46636", "l": "5beta-dihydrotestosterone + NADP(+) = H(+) + NADPH + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008889", "l": "glycerophosphodiester phosphodiesterase activity", "d": ["Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102685", "l": "UDP-glucose:trans-zeatin 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + trans-zeatin = H+ + trans-zeatin-7-N-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034945", "l": "2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity", "d": ["Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-isopropylbut-3-enoyl-CoA + propanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636261", "l": "NOS2 gene produces NOS2 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75956", "l": "2-oxoglutarate + O2 + thebaine => CO2 + formaldehyde + oripavine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383190", "l": "HCO3- transport through ion channel (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444792", "l": "Calmodulin-bound CaMKII-gamma enters the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050003", "l": "deoxycytidylate C-methyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = 2'-deoxy-5-methyl-5'-cytidylate + 7,8-dihydrofolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52447", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose <=> 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58420", "l": "NADP(+) + prenol = 3-methyl-2-butenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265940", "l": "Rad51 assembly at the DNA-damage sites on the chromatin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76584", "l": "(2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + 2 H(+) + NADH => (6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676589", "l": "RANKL,sRANKL trimer binds RANK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627056", "l": "Procaspase 9 forms dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.-", "l": "\"Phosphotransferases with an alcohol group as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69584", "l": "GMP + inosine = guanosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31193", "l": "(2E)-decenoyl-CoA + H2O => (3S)-hydroxydecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0004660", "l": "protein farnesyltransferase activity", "d": ["Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51715", "l": "keto-D-tagatose 6-phosphate <=> keto-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140376", "l": "innate immune receptor activity", "d": ["Receiving a signal and transmitting it in a cell to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419334", "l": "Melatonin receptors can bind melatonin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79097", "l": "an N-choloyl-L-alpha-amino acid + glycine => an L-alpha-amino acid + glycocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140217", "l": "Transactivation of PMAIP1 (NOXA) by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31180", "l": "(3S)-3-hydroxydodecanoyl-CoA + NAD(+) => 3-oxododecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22368", "l": "L-ribulose 5-phosphate = D-xylulose 5-phosphate", "d": [], "t": []}, {"i": "EC:5.1.3.4", "l": "\"L-ribulose-5-phosphate 4-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40580", "l": "1-O-(1Z)-hexadecenyl-2 (5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418456", "l": "cGMP is degraded by PDEs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0036313", "l": "phosphatidylinositol 3-kinase catalytic subunit binding", "d": ["Binding to the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75005", "l": "AMP + diphosphate + sulfoacetyl-CoA => ATP + CoA + sulfoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55071", "l": "a 12-oxojasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76485", "l": "2 Fe(III)-[cytochrome b5] + 2 H2O + sphinga-4E,14Z-dienine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72602", "l": "N-acetyl-L-aspartyl-L-glutamate(out) <=> N-acetyl-L-aspartyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182988", "l": "Sprouty lures CBL away from EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621363", "l": "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617927", "l": "FOXO4 binds ATXN3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9861563", "l": "CTLH E3 ligase ubiquitinates LDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43094", "l": "2'-O-methyluridine(2479) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(2479) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45842", "l": "3-oxodecanoyl-CoA + H(+) + NADPH => (3R)-3-hydroxydecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997309", "l": "Dephosphorylation of STAT1 by SHP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9825704", "l": "AKT3 phosphorylates TBX3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30332", "l": "all-trans-beta-carotene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70241", "l": "PCK1 phosphorylates OA to yield PEP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55395", "l": "an adenosine in mRNA + S-adenosyl-L-methionine <=> an N(1)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25514", "l": "chorismate + L-glutamine => (2S)-2-amino-4-deoxychorismate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37790", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12683", "l": "N-methylhydantoin + NH4(+) => creatinine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37505", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052818", "l": "heteroglycan 3-alpha-mannosyltransferase activity", "d": ["Catalysis of the reaction: heteroglycan + GDP-mannose = (1->3)-alpha-D-mannosylheteroglycan + GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336182", "l": "GPR37 binds prosaptide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22043", "l": "H2O + N-formyl-L-aspartate <=> formate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666001", "l": "Profilin:G-actin binds MKL1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73837", "l": "2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44665", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429694", "l": "CERT1-2 complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033801", "l": "vitexin 2''-O-rhamnoside 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59266", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209903", "l": "Noradrenaline is converted to adrenaline (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78225", "l": "(S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+) => D-allo-isoleucine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62631", "l": "a hydroperoxide + H(+) + NADH <=> an alcohol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218804", "l": "p38 MAPK activation by VEGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210291", "l": "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40277", "l": "(2E)-hexadecenedioyl-CoA + H2O2 => hexadecanedioyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30339", "l": "H(+) + L-tryptophan = CO2 + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56606", "l": "6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19548", "l": "H2O + sn-glycerol 3-phosphocholine <=> glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47322", "l": "3-oxo-3-phenylpropanoate + L-glutamate => (S)-3-amino-3-phenylpropanoate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.10", "l": "\"enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73873", "l": "(R)-noradrenaline(in) => (R)-noradrenaline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73596", "l": "dCMP + H2O => dUMP + NH4+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903879", "l": "11beta-hydroxyprogesterone binding", "d": ["Binding to 11beta-hydroxyprogesterone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60067", "l": "a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624494", "l": "RAF1 binds p21 RAS:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031219", "l": "levanase activity", "d": ["Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65479", "l": "1-propanol + butanoyl-CoA <=> CoA + propyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5681987", "l": "LC3 is cleaved by ATG4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78745", "l": "D-glucose + ipecoside aglycone => H2O + ipecoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64600", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0051378", "l": "serotonin binding", "d": ["Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62071", "l": "2-deoxy-D-glucose 6-phosphate + NADP(+) <=> 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.92", "l": "\"3,6-anhydro-alpha-L-galactose dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028526", "l": "NR1H2 or NR1H3, NRIP1 bind the SCD gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71066", "l": "L-arginine(in) + L-histidine(out) <=> L-arginine(out) + L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55399", "l": "(R)-carnitine + H(+) + NADH + O2 <=> (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73407", "l": "(S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20784", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginine = ADP-D-ribose + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54714", "l": "3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine => N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782138", "l": "ERCC5 and RPA bind TC-NER site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57708", "l": "(E)-coniferaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36233", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76663", "l": "H2O + NADP(+) + pentanal = 2 H(+) + NADPH + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044824", "l": "retroviral 3' processing activity", "d": ["The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42328", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77940", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate => 1,3-di-(9Z,12Z)-octadecadienoylglycerol + 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781941", "l": "WNTs are secreted in exosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033815", "l": "biphenyl synthase activity", "d": ["Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34889", "l": "selenate(out) => selenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228811", "l": "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39330", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA <=> (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53410", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.42", "l": "\"thermopsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205117", "l": "p75NTR:NADE promotes caspase2/3 activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51559", "l": "(S)-glaucine + S-adenosyl-L-methionine <=> (S)-N-methylglaucine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57270", "l": "GMP + H(+) + lactate => H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52369", "l": "3'-phosphoadenylyl sulfate + cholesterol => adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41520", "l": "menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047403", "l": "lacto-N-biosidase activity", "d": ["Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937419", "l": "CBR3 reduces DOX to DOXOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.23", "l": "\"beta-galactosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168638", "l": "Activated IKK phosphorylates I-kappaB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16379", "l": "biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019151", "l": "galactose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692297", "l": "DMRT1 binds the WNT4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74748", "l": "myricetin + S-adenosyl-L-methionine => 3-O-methylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69511", "l": "H2O + N-acetyl-D-glucosamino-1,5-lactone <=> H(+) + N-acetyl-D-glucosaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74504", "l": "H(+) + NADPH + yaequinolone D => H2O + NADP(+) + penigequinolone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033755", "l": "sulfur oxygenase/reductase activity", "d": ["Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78359", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.30.1", "l": "\"Aspergillus nuclease S1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0052713", "l": "inositol phosphorylceramide phospholipase activity", "d": ["Catalysis of the reaction: inositol phosphorylceramide + H2O = C26-phytoceramide + phosphorylinositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40236", "l": "coenzyme B + coenzyme M + fumarate => coenzyme M-coenzyme B heterodisulfide + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15362", "l": "a dolichyl phosphate + UDP-alpha-D-xylose => a dolichyl D-xylosyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31585", "l": "2-oxo-dAMP + diphosphate + H(+) => 2-oxo-dATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65612", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] = a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "64.053760442736788", "identifiers": [{"i": "GO:0008194", "l": "UDP-glycosyltransferase activity", "d": ["Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule."], "t": []}, {"i": "REACT:R-HSA-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989765", "l": "Expression of ABCA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38819", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29074", "l": "a ubiquinone + formate + H(+) <=> a ubiquinol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912363", "l": "MIR200B/C microRNAs bind NOTCH1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14347", "l": "CO2 + tyramine => H(+) + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388468", "l": "AVP(20-28) binds AVPR1A,B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66339", "l": "L-glutamate(out) <=> L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47802", "l": "an aromatic oxo-acid + L-methionine => 4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34380", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32147", "l": "H2O + sepiapterin = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035527", "l": "3-hydroxypropionate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49747", "l": "deoxyviolaceinate + H(+) + O2 <=> CO2 + deoxyviolacein + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61142", "l": "CO2 + H(+) + H2O + myricetin + succinate => (2R,3R)-dihydromyricetin + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75060", "l": "chloride(out) + 2 hydrogencarbonate(in) + K(+)(in) => chloride(in) + 2 hydrogencarbonate(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11176", "l": "kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.230", "l": "\"kojibiose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982645", "l": "GRKs bind ADRB2:Catecholamine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62610", "l": "S-sulfanylglutathione + ubiquinol-10 => glutathione + H(+) + hydrogen sulfide + ubiquinone-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53425", "l": "a fatty acyl-CoA + a sphingoid base => an N-acyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59439", "l": "4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] <=> 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098615", "l": "dimethyl selenide methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl selenide => S-adenosyl-L-homocysteine + trimethylselenonium."], "t": []}, {"i": "REACT:R-HSA-2408554", "l": "Me2Se is methylated to Me3Se+ by INMT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373705", "l": "Caspase cleavage of DCC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54888", "l": "(1S,2S)-OPC-8 + ATP + CoA = AMP + diphosphate + OPC8-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426032", "l": "DAG is metabolized by DAGL to 2-AG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28507", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP => 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57985", "l": "(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose => (20S)-ginsenoside Rd + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.108", "l": "\"protein adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28693", "l": "a ubiquinol + orotate => (S)-dihydroorotate + a ubiquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67806", "l": "CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202917", "l": "Caspase-mediated cleavage of Desmoglein 1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209921", "l": "Monoiodinated tyrosine can be deiodinated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37625", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41748", "l": "3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = 1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13623", "l": "1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose => 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14531", "l": "ADP-D-ribose + phosphate => ADP + D-ribose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660663", "l": "Caspase-8 cleaves IL1B precursor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614933", "l": "ACEIs bind ACE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031783", "l": "type 5 melanocortin receptor binding", "d": ["Binding to a type 5 melanocortin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047228", "l": "1,2-diacylglycerol 3-glucosyltransferase activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614461", "l": "Tetramerization of procollagen VI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49239", "l": "N(pros)-phospho-L-histidyl-[protein](out) + sucrose <=> L-histidyl-[protein] + sucrose 6(G)-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77094", "l": "Formation of cap binding complex (CBC) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31061", "l": "2 H(+) + imidazole-4-acetate + NADH => H2O + imidazole-4-acetaldehyde + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10651", "l": "2-hydroxycyclohexan-1-one + H(+) + NADPH + O2 <=> 6-hydroxyhexan-6-olide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856056", "l": "MITF-M dimer binds GPR143 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985123", "l": "RNASEL binds 2'-5' oligoadenylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32068", "l": "8-oxoguanine + H(+) + H2O => NH4(+) + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48050", "l": "a ganglioside GM2 (d18:1(4E)) + D-galactose => a ganglioside GM1 (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034511", "l": "U3 snoRNA binding", "d": ["Binding to a U3 small nucleolar RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23044", "l": "H(+) + N,N-dihydroxy-L-tyrosine = (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54085", "l": "7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine => archaeosine(15) in tRNA + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39245", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+) => (11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47333", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754129", "l": "CDK6 inhibitors bind CDK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351596", "l": "Dopamine translocates to a secretory vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001639", "l": "PLC activating G protein-coupled glutamate receptor activity", "d": ["A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77694", "l": "a ganglioside GD1b (d18:1(4E)) + GDP-beta-L-fucose <=> a ganglioside Fuc-GD1b (d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12651", "l": "H(+) + L-rhamnono-1,4-lactone + NADH => L-rhamnofuranose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26140", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O = 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56410", "l": "1-(9Z-octadecaenoyl)-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013147", "l": "RAC1 GDIs block activation of RAC1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59186", "l": "2-acetylphloroglucinol + acetate => 2,4-diacetylphloroglucinol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17995", "l": "ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate => ATP + beta-alanine + gamma-L-glutamyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604722", "l": "Activation of proMMP9 by proteases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69474", "l": "a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71187", "l": "3-hydroxy-L-kynurenine(out) + L-tryptophan(in) = 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015432", "l": "ABC-type bile acid transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070968", "l": "pyrroloquinoline quinone binding", "d": ["Binding to pyrroloquinoline quinone, PQQ, the coenzyme or the prosthetic group of certain alcohol dehydrogenases and glucose dehydrogenases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173680", "l": "Activation of C5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709842", "l": "MAVS binds TOMM70 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63830", "l": "pyruvate + vanillylamine => L-alanine + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.72", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018798", "l": "RHOV binds GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61403", "l": "ATP + N(6)-(D-ribulosyl)-L-lysine <=> ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672817", "l": "Active MTORC1 binds the ULK1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53475", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54522", "l": "cycloaraneosene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102796", "l": "protocatechualdehyde:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxybenzaldehyde + O2 + H2O = H+ + 3,4-dihydroxybenzoate + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57868", "l": "(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 = (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.62", "l": "\"trans-4-coumaroyl-CoA 2'-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004855", "l": "xanthine oxidase activity", "d": ["Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646468", "l": "mTORC1 binds RHEB:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709360", "l": "H2O2 reduces MetHb (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66311", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose <=> an alpha-mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9718379", "l": "GNRHR binds chemical antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202714", "l": "CD58 binds CD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61632", "l": "5-aminopentanal + H2O + NAD(+) = 5-aminopentanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44149", "l": "L-lysine => D-beta-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789077", "l": "Hydrogen peroxide enters the bacterium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26204", "l": "ammeline + H(+) + H2O <=> ammelide + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41720", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21301", "l": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429860", "l": "DCP1-DCP2 complex decaps mRNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74580", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] => N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31365", "l": "2 H(+) + NADPH + oxidized coenzyme F420-(gamma-L-Glu)(n) => NADP(+) + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10520", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.241", "l": "\"digalactosyldiacylglycerol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64821", "l": "2-phenylacetamide + H2O => 2-phenylacetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088305", "l": "FOXM1 stimulates PLK1 transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75845", "l": "ergothioneine(in) + Na(+)(in) => ergothioneine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373087", "l": "Receptor CCR6 binds CCL20 ligand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54369", "l": "acetaldehyde + H(+) + pyruvate => acetoin + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033556", "l": "dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity", "d": ["Catalysis of the addition of a glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(7)GlcNAc(2)-PP-Dol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033970", "l": "N-malonylurea hydrolase activity", "d": ["Catalysis of the reaction: 3-oxo-3-ureidopropanoate + H2O = H+ + malonate + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2272668", "l": "Interaction of DAP12 and KIR2DS5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55104", "l": "3-oxoheptanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyheptanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419153", "l": "5-phosphoribosylamine + glycine + ATP <=> 5-phosphoribosylglycinamide (GAR) + adenosine 5'-diphosphate + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67331", "l": "(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione <=> trichosetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163602", "l": "2 phosphorylated HSL monomers -> phosphorylated HSL dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26165", "l": "AH2 + echinenone + O2 => 4'-hydroxyechinenone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018753", "l": "cyanuric acid amidohydrolase activity", "d": ["Catalysis of the reaction: cyanurate + H2O = 1-carboxybiuret + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51090", "l": "13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63472", "l": "all-trans-hexaprenol + ATP = ADP + all-trans-hexaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244647", "l": "cGAS binds cytosolic DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3785711", "l": "Telomere shortening during replicative exhaustion (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38310", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22235", "l": "H(+) + NADPH + presqualene diphosphate <=> diphosphate + NADP(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20918", "l": "hydrogen sulfide + L-cysteate => L-cysteine + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448741", "l": "IL22RA2 binds IL22 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40091", "l": "26-hydroxyhexacosanoate + NAD(+) = 26-oxohexacosanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467209", "l": "Binding of defensins to lipid II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033401", "l": "UUU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46899", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) <=> a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66181", "l": "(4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside(in) + ATP + H2O => (4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374681", "l": "L1 and NCAM1 engaged in cis-interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961961", "l": "E2F1 binds the CDC25A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28687", "l": "(S)-dihydroorotate + ubiquinone-8 = orotate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20445", "l": "L-arogenate + oxaloacetate = L-aspartate + prephenate", "d": [], "t": []}, {"i": "EC:2.6.1.78", "l": "\"aspartate--prephenate aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59739", "l": "L-cysteinyl-[protein] + tetradecanoyl-CoA <=> CoA + S-tetradecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9833973", "l": "ISGylation of PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59447", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A <=> 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932275", "l": "METTL22 transfers 3xCH3 from 3xAdoMet to KIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023171", "l": "Insulin secretory granule translocates across the cortical actin network (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749215", "l": "MCM8 binds CDC6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008824", "l": "cyanate hydratase activity", "d": ["Catalysis of the reaction: cyanate + H2O = carbamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9861631", "l": "ME1 tetramerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217150", "l": "Monoubiquitination of FancD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827994", "l": "SOX17 binds the PDPN gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38824", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37156", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + heptadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.40", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44973", "l": "(R)-carnitine + hexanoyl-CoA => CoA + O-hexanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11177", "l": "kojibiose + phosphate => beta-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73262", "l": "cirsiliol + S-adenosyl-L-methionine <=> eupatorin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.3.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18428", "l": "L-quinate + NADP(+) <=> 3-dehydroquinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45786", "l": "3-phenylpropanoate + NH4(+) => 2 H2O + phenylpropanonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22438", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72501", "l": "2-oxoglutarate(out) + prostaglandin E2(in) => 2-oxoglutarate(in) + prostaglandin E2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216043", "l": "Collagen type II binds integrin alpha10beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60156", "l": "ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.5.2.11", "l": "\"ABC-type D-galactose transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448632", "l": "IL34 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14626", "l": "[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) => [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.19", "l": "\"aspergillopepsin II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379464", "l": "COMT transfers Met to DOPAC to form HVA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140788", "l": "L-glutamate uniporter activity", "d": ["Catalysis of the active transport of a L-glutamate across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74826", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27477", "l": "2-oxoglutarate + O2 + thebaine = CO2 + formaldehyde + neopinone + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.31", "l": "\"thebaine 6-O-demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042970", "l": "homoserine transmembrane transporter activity", "d": ["Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53547", "l": "chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008687", "l": "3,4-dihydroxyphenylacetate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O2 = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58792", "l": "ATP + Fe(III)-petrobactin(out) + H2O = ADP + Fe(III)-petrobactin(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58318", "l": "cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64087", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) <=> 2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44468", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol = a 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78802", "l": "a D-alpha-amino acid + O2 <=> a 2-iminocarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043899", "l": "phosphoserine:homoserine phosphotransferase activity", "d": ["Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044693", "l": "trehalose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: trehalose(out) + H+(out) = trehalose(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354073", "l": "Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30250", "l": "2 H2O + 4 hnu + 2 plastoquinone-9 <=> O2 + 2 plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55008", "l": "(1R,4S)-1-hydroxylimonen-2-one + NADPH + O2 = (3S)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18570", "l": "an aromatic aldehyde + H2O + O2 => an aromatic carboxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724685", "l": "IgE binds omalizumab (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27854", "l": "(2E)-geranyl diphosphate + 4-hydroxybenzoate = 3-geranyl-4-hydroxybenzoate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.93", "l": "\"4-hydroxybenzoate geranyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30311", "l": "7-methylxanthine + H(+) + NADH + O2 = formaldehyde + H2O + NAD(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0070180", "l": "large ribosomal subunit rRNA binding", "d": ["Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22017", "l": "[glutaredoxin]-dithiol + arsenate + glutathione + H(+) => arsenite + glutathionyl-S-S-[glutaredoxin] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29490", "l": "(2E,6E)-farnesyl diphosphate <=> cis-muurola-3,5-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043750", "l": "phosphatidylinositol alpha-mannosyltransferase activity", "d": ["Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852019", "l": "MET bound PI3K generates PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70927", "l": "(R)-glycerate(in) + H(+)(in) = (R)-glycerate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25158", "l": "AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine => (R)-4'-phosphopantothenate + ATP + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50839", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 <=> 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14388", "l": "a dolichyl diphosphate + H2O <=> a dolichyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22307", "l": "a ubiquinone + keto-D-fructose <=> 5-dehydro-D-fructose + a ubiquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62669", "l": "deoxyherqueinone + H(+) + NADPH + O2 => H2O + herqueinone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950410", "l": "IL12B:IL12B translocates from ER lumen to the extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004974", "l": "leukotriene receptor activity", "d": ["Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48932", "l": "a ganglioside GT1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8858428", "l": "FCAMR binds IgA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70809", "l": "4-deoxy-4-sulfo-D-erythrulose => 4-deoxy-4-sulfo-D-erythrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17824", "l": "hydrogen cyanide + L-cysteine <=> 3-cyano-L-alanine + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759325", "l": "NFE2L2 binds the GSTA3 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69839", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.17", "l": "\"deoxyribodipyrimidine endonucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64333", "l": "ATP + CoA + nicotinate => AMP + diphosphate + nicotinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40600", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692738", "l": "HRH2 binds HRH2 antagonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48776", "l": "O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58120", "l": "ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32336", "l": "(1S,2S,4R)-endo-fenchol + NADP(+) => (1S,4R)-fenchone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0052887", "l": "7,9,9'-tricis-neurosporene:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: 7,9,9'-tri-cis-neurosporene + a quinone = 7,9,7',9'-tetra-cis-lycopene + a quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004337", "l": "geranyltranstransferase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66111", "l": "2-oxobutanoate + L-cysteine <=> (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34589", "l": "CO2 + pentalenolactone F + succinate => 2-oxoglutarate + O2 + pentalenolactone E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69692", "l": "a ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine => a ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.213", "l": "\"3alpha-hydroxysteroid dehydrogenase (Re-specific)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61344", "l": "H2O + L-serine + O2 = 3-hydroxypyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820840", "l": "DICER1 hydrolyzes maternal mRNA:lncRNA to yield endosiRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507870", "l": "Aquaporins passively transport water out of cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685179", "l": "SARS-CoV-1 N protein binds TRIM25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41811", "l": "(3R)-hydroxybutanoyl-[ACP] <=> (2E)-butenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11546", "l": "H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine => H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687121", "l": "nsp8 binds MAP1LC3B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73031", "l": "Cd(2+)(out) + H(+)(out) = Cd(2+)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60629", "l": "AH2 + gluconapin + O2 => A + H2O + progoitrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22334", "l": "2-methylmaleate + H2O => (3R)-citramalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428231", "l": "ACER1 hydrolyzes ceramide (endoplasmic reticulum) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174097", "l": "Association of Emi1 with Cdh1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638209", "l": "Defective SLC2A9 does not transport Fru, Glc, urate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31244", "l": "H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) => (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43568", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NAD(+) = 3,6-anhydro-L-galactonate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483219", "l": "PC is exchanged with PI by PITPNB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850945", "l": "Casein kinase II phosphorylates PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006873", "l": "IL21 receptor STAT binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198714", "l": "ERK5 translocates to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16623", "l": "H2O2 + sanguinarine => dihydrosanguinarine + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798749", "l": "Exocytosis of specific granule lumen proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43435", "l": "butan-1-ol + 2 Fe(III)-[cytochrome c] <=> butanal + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45062", "l": "(9Z)-octadecenoate + ethanolamine => H2O + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866304", "l": "pre-VLDL binds lipids to form VLDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001735", "l": "prenylcysteine oxidase activity", "d": ["Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852200", "l": "Inactivation of LCK by PTPN22 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003829", "l": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005459", "l": "UDP-galactose transmembrane transporter activity", "d": ["Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0002020", "l": "protease binding", "d": ["Binding to a protease or a peptidase."], "t": []}, {"i": "REACT:R-HSA-1297354", "l": "Acrosin Cleavage (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9838035", "l": "CLPXP binds mitochondrial matrix proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.21", "l": "\"inositol-hexakisphosphate 5-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41894", "l": "(2E)-tetradecenoyl-[ACP] + H2O => (3R)-hydroxytetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0072570", "l": "ADP-D-ribose binding", "d": ["Binding to ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696274", "l": "RND1 binds GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141367", "l": "Myristoylation of tBID by NMT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36757", "l": "beta-D-Glc-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25841", "l": "5-deoxy-D-glucuronate => 5-dehydro-2-deoxy-D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22222", "l": "diphosphate + ent-kaur-16-ene => ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368588", "l": "DVL binds CCDC88C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54997", "l": "3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11473", "l": "an N-methyl-L-amino acid + H2O + O2 => an L-alpha-amino acid + formaldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36226", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140691", "l": "RNA folding chaperone", "d": ["Binding to an RNA or an RNA-containing complex to assist the folding process."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20620", "l": "L-galactono-1,4-lactone + O2 <=> H(+) + H2O2 + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21036", "l": "2 acetyl-CoA = acetoacetyl-CoA + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.9", "l": "\"acetyl-CoA C-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649856", "l": "Oxidative damage to the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912374", "l": "Transport of NOTCH precursor to Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754974", "l": "ADK phosphorylates RBV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010428", "l": "methyl-CpNpG binding", "d": ["Binding to a methylated cytosine/unspecified/guanine trinucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17971", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine => ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047527", "l": "2,3-dihydroxybenzoate-serine ligase activity", "d": ["Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66619", "l": "Mg(2+)(in) + 2 Na(+)(out) <=> Mg(2+)(out) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061758", "l": "2-hydroxyglutarate dehydrogenase activity, forward reaction", "d": ["Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor -> 2-oxoglutarate + reduced acceptor."], "t": []}, {"i": "RHEA:21253", "l": "(S)-2-hydroxyglutarate + A => 2-oxoglutarate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15272", "l": "L-xylo-hex-3-ulonolactone <=> H(+) + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67121", "l": "N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44131", "l": "(9E)-octadecenoyl-CoA + hexadecan-1-ol <=> CoA + hexadecanyl (9E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.36", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55614", "l": "1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+) => an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035255", "l": "ionotropic glutamate receptor binding", "d": ["Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23040", "l": "2-oxobutanoate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.6", "l": "\"2-ethylmalate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20255", "l": "dimethylmaleate + H2O => (2R,3S)-2,3-dimethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.20", "l": "\"ribonuclease U2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050291", "l": "sphingosine N-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51253", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033935", "l": "oligoxyloglucan beta-glycosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78050", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine <=> 1-O-alkyl-2-acetyl-3-acylglycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047283", "l": "dolichyl-phosphate D-xylosyltransferase activity", "d": ["Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61882", "l": "1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052582", "l": "(+)-menthofuran synthase activity", "d": ["Catalysis of the reaction: (R)-pulegone + reduced [NADPH--hemoprotein reductase] + O2 = (R)-menthofuran + 2 H2O + +H+ + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45950", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[protein] => acetyl-CoA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12901", "l": "D-arginine + H2O = D-ornithine + urea", "d": [], "t": []}, {"i": "EC:3.5.3.10", "l": "\"D-arginase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66406", "l": "ADP + glutathione(out) + H(+) + phosphate + taurocholate(out) => ATP + glutathione(in) + H2O + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31452", "l": "2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) => a cardiolipin + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388830", "l": "PI3K binds ICOS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672083", "l": "KTN1 binds Kinesin-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77976", "l": "dimethylallyl diphosphate + 5 isopentenyl diphosphate => all-trans-hexaprenyl diphosphate + 5 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130349", "l": "Generation of CLIP from lip10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018798", "l": "RHOV binds GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0099186", "l": "structural constituent of postsynapse", "d": ["The action of a molecule that contributes to the structural integrity of a postsynapse."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61330", "l": "3beta-hydroxyparthenolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + parthenolide + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661432", "l": "BIL binds ALB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.42", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0101016", "l": "FMN-binding domain binding", "d": ["Binding to the FMN-binding domain of a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70297", "l": "3-sulfinopyruvate + L-glutamate => 2-oxoglutarate + 3-sulfino-L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983153", "l": "E1 mediated ubiquitin activation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16979", "l": "2-oxopropyl-coenzyme M + CO2 + NADPH => acetoacetate + coenzyme M + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31429", "l": "(1S,5S,6R)-alpha-bergamotene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71372", "l": "epitestosterone 17-sulfate(out) + 2 Na(+)(out) => epitestosterone 17-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.59", "l": "\"tryptase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018724", "l": "4-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112395", "l": "Abortive termination of elongation after arrest (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27696", "l": "(S)-3-methyl-2-oxopentanoate + H2O => (2R,3R)-2,3-dihydroxy-3-methylpentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51347", "l": "(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate <=> 8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10882", "l": "7-methylxanthine + D-ribose + H(+) => 7-methylxanthosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71316", "l": "chloride(out) + L-serine(out) + 2 Na(+)(out) => chloride(in) + L-serine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806394", "l": "TP53 and AP-1 stimulate MSH2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876446", "l": "p-ULK1 phosphorylates DENND3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444691", "l": "Prokineticin receptors bind prokineticin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0043139", "l": "5'-3' DNA helicase activity", "d": ["Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40374", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ATP <=> 3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76988", "l": "an N-acylsphing-4-enine(in) => an N-acylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39748", "l": "cholesterol(in) => cholesterol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43205", "l": "cytidine(1409) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1409) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801776", "l": "REG3A binds bacterial phospholipids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380294", "l": "Loss of C-Nap-1 from centrosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686005", "l": "nsp3 binds to nsp7-8 and nsp12-16 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67294", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one => (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380586", "l": "loading of Serotonin in synaptic vesicles (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73593", "l": "CTP(in) + dUTP(out) => CTP(out) + dUTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53420", "l": "8-demethyl-8-(methylamino)riboflavin + S-adenosyl-L-methionine = H(+) + roseoflavin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684008", "l": "NBN binds KPNA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11002", "l": "a D-alpha-amino acid + CO2 + NH4(+) => an N-carbamoyl-D-amino acid + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701211", "l": "TRPA1 tetramer binds TRPA1 antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25275", "l": "ADP + H(+) + N(6)-(UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl)-D-lysine + phosphate => ATP + D-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25882", "l": "2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+) => 2 L-dopa + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16214", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39231", "l": "3-oxo-triacontanoyl-CoA + H(+) + NADPH = (3R)-hydroxytriacontanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40064", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O => 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49326", "l": "all-trans-capsorubin => (5R,6S)-5,6-epoxi-capsanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22001", "l": "D-xylose + NADP(+) => D-xylono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333607", "l": "GSSeH combines with bGalNAc derivative to form GSSebGalNac (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50148", "l": "a fatty acid ethyl ester + H2O = a fatty acid + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936989", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74030", "l": "L-alanine(in) + L-threonine(out) <=> L-alanine(out) + L-threonine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43194", "l": "2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine => cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734337", "l": "NKX2-5 binds the TBX5 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034806", "l": "benzo(a)pyrene 11,12-dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-11,12-dihydrodiol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28880", "l": "H(+)(in) + L-tryptophan(in) => H(+)(out) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0045547", "l": "dehydrodolichyl diphosphate synthase activity", "d": ["Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16631", "l": "acetyl-CoA + glyoxylate => (S)-malyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508451", "l": "PTK2B is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30263", "l": "H2O2 + 2 L-ascorbate = 2 H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786650", "l": "DDHD1,2 hydrolyse PA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33818", "l": "CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate <=> 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72447", "l": "a dicarboxylate(in) + estrone 3-sulfate(out) = a dicarboxylate(out) + estrone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13902", "l": "H2O + N-(aminomethyl)urea => N-(hydroxymethyl)urea + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19043", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32433", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+) => (1R,4S)-menthone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64598", "l": "an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+) => a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56340", "l": "ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34228", "l": "5-nitrosalicylate + O2 => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43525", "l": "L-allo-threonine + NADP(+) => aminoacetone + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58672", "l": "D-glucuronate = aldehydo-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42326", "l": "3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66542", "l": "AH2 + cholesta-5,7-dien-3beta,25-diol => 7-dehydrocholesterol + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45458", "l": "dodecanoate + ethanolamine => H2O + N-dodecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247960", "l": "Activation of p38 MAPK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64602", "l": "a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-976991", "l": "Prolactin receptor ligands bind the prolactin receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22020", "l": "ATP + H2O + molybdate(out) = ADP + H(+) + molybdate(in) + phosphate", "d": [], "t": []}, {"i": "EC:7.3.2.5", "l": "\"ABC-type molybdate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850831", "l": "KLK5 cleaves and activates KLK8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68960", "l": "DNA polymerase epsilon binds at the origin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211950", "l": "CYP24A1 24-hydroxylates CTL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68966", "l": "2-oxooctadecanoate + H2O2 => 2-hydroxyoctadecanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033284", "l": "NTRK2 promotes TIAM1 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-532549", "l": "MPI isomerises Fru6P to Man6P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16043", "l": "[(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->3)-beta-D-glucosyl](n) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25609", "l": "beta-D-allofuranose = beta-D-allopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389758", "l": "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10296", "l": "D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203070", "l": "Association of profilin with monomeric actin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018573", "l": "NOTCH3 binds activated EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68293", "l": "L-seryl-[protein] + nonanoyl-CoA => CoA + O-nonanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72381", "l": "chloride(in) + iodide(out) => chloride(out) + iodide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465924", "l": "OPN1LW binds 11cRAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50783", "l": "NADP(+) + octanal <=> (2E)-octenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26272", "l": "Co-precorrin-2 + 3 H(+) <=> Co(2+) + precorrin-2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37543", "l": "2-amino-5-chlorophenol + O2 = 2-amino-5-chloromuconate 6-semialdehyde", "d": [], "t": []}, {"i": "EC:1.13.11.76", "l": "\"2-amino-5-chlorophenol 1,6-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102602", "l": "cytochrome P450 dependent 16beta-hydroxy-beta-amyrin epoxidase activity", "d": ["Catalysis of the reaction: 16beta-hydroxy-beta-amyrin + O2 + H+ + NAD(P)H = 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70994", "l": "H(+)(in) + L-mannopyranose(in) <=> H(+)(out) + L-mannopyranose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627104", "l": "XIAP binds CASP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45690", "l": "N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(out) => N-(9Z-octadecenoyl)-sphing-4-enine-1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794523", "l": "SLC22A1 transports Cipro into renal cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797803", "l": "PTPRD binds SLITRK1-6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52122", "l": "(19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036175", "l": "ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor", "d": ["Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21216", "l": "ATP + D-ribose 5-phosphate = ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.18", "l": "\"phosphoribokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034010", "l": "sulfolactate sulfo-lyase activity", "d": ["Catalysis of the reaction: 3-sulfolactate = pyruvate + sulfite."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.55", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70045", "l": "2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + teasterone => 6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16742", "l": "a 2-acylglycerol + an acyl-CoA => a 1,2-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640195", "l": "RRAGA,B hydrolyzes GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72380", "l": "chloride(out) + iodide(in) => chloride(in) + iodide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43040", "l": "hexadecanoyl-CoA + hexadecasphinganine = CoA + H(+) + N-hexadecanoylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809521", "l": "BPIF binds bacteria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43016", "l": "an S-alkyl-L-cysteine = 2-aminoprop-2-enoate + an alkyl thiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013024", "l": "RHOB binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37187", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycerol 3-phosphate = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750942", "l": "USP14 deubiquitinates NLRC5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28781", "l": "glycine + glycolaldehyde => 4-hydroxy-L-threonine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55520", "l": "dimethylallyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + nerylneryl diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.142", "l": "\"nerylneryl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14296", "l": "D-glucose + NAD(+) <=> D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50122", "l": "CoA + H(+) + N-tetracosanoyl-taurine => taurine + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794475", "l": "Cipro:ALB dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72205", "l": "2 chloride(in) + hydrogencarbonate(out) => 2 chloride(out) + hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55391", "l": "(3R)-3-hydroxy-2,3-dihydrotabersonine + A <=> (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34750", "l": "15-methylhexadecasphinganine + ATP <=> 15-methylhexadecasphinganine 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71524", "l": "adenine(out) => adenine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46121", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65833", "l": "AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O => A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46446", "l": "(10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O => (11Z)-hexadecenoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31715", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12644", "l": "(2R)-3-phosphoglycerate + NAD(+) <=> 3-phosphooxypyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68688", "l": "3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate) = 3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42366", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25047", "l": "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O => (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38677", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64782", "l": "2-aminoprop-2-enoate + benzylthiol => S-benzyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21612", "l": "D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21224", "l": "CDP-choline + sphing-4-enine = CMP + H(+) + sphing-4-enine-phosphocholine", "d": [], "t": []}, {"i": "EC:2.7.8.10", "l": "\"sphingosine cholinephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168638", "l": "Activated IKK phosphorylates I-kappaB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10860", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 = 2-(acetamidomethylene)succinate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77532", "l": "hydrogen cyanide + nonanal => (2S)-2-hydroxydecanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39054", "l": "ATP + cholesterol(in) + H2O <=> ADP + cholesterol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55086", "l": "(3R)-3-hydroxypentanoate + CoA + H(+) => (3R)-3-hydroxypentanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45595", "l": "H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59994", "l": "(E)-4-coumarate + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + phloretate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17029", "l": "(S)-allantoin + H2O = allantoate + H(+)", "d": [], "t": []}, {"i": "EC:3.5.2.5", "l": "\"allantoinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-165195", "l": "GTP loading by Rheb (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931981", "l": "RUNX1 binds ESR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60106", "l": "(E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein] => H(+) + indole-3-propanoate + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047006", "l": "17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46592", "l": "alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726621", "l": "PGR binds PGR antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734475", "l": "PPARA binds fibrates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12043", "l": "(S)-3-(imidazol-5-yl)lactate + NADP(+) <=> 3-(imidazol-5-yl)pyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41209", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+) => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426209", "l": "DAG activation of TRPC channels (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709547", "l": "ESTG binds ESR2:chaperone complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49141", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58207", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetrahydroalstonine <=> dihydroalstonine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.15", "l": "\"(methyl)glyoxal oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46812", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102045", "l": "3-chlorobenzoate-3,4-oxygenase activity", "d": ["Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor = 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878914", "l": "B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75891", "l": "Abortive Initiation After Second Transition (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71163", "l": "HPD dioxygenates HPP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31509", "l": "H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate => aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33843", "l": "H2O + N-tetracosanoylsphinganine = sphinganine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15772", "l": "adenosylcob(III)inamide + ATP <=> adenosylcob(III)inamide phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56871", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA <=> (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984733", "l": "Kinesin-3 is a dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76515", "l": "H2O + orobanchol = 5-hydroxy-3-methylfuran-2(5H)-one + orobanchol ABC-rings", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67781", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76332", "l": "L-aspartate(in) + L-tyrosine(out) => L-aspartate(out) + L-tyrosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193097", "l": "Pregnenolone translocates from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209536", "l": "IkB is ubiquitinated and degraded (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619355", "l": "CaMKK autophosphorylates in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010210", "l": "IAA-Phe conjugate hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetyl-phenylalanine + H2O = indole-3-acetate + phenylalanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65281", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate => 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71254", "l": "L-xylopyranose <=> L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29540", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218824", "l": "p-6Y-VEGFR2 binds FYN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2545253", "l": "Deacetylation of cohesin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004068", "l": "aspartate 1-decarboxylase activity", "d": ["Catalysis of the reaction: L-aspartate = beta-alanine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052831", "l": "inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate."], "t": []}, {"i": "REACT:R-HSA-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6813740", "l": "GDE1 hydrolyzes GroPIns (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73629", "l": "CTP(in) + GMP(out) => CTP(out) + GMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58299", "l": "25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine <=> 25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28258", "l": "cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate = cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.254", "l": "\"cyanidin-3-O-glucoside 2''-O-glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18625", "l": "D-galactose + NADP(+) = D-galactono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13864", "l": "D-xylose + NAD(+) <=> D-xylono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30633", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40242", "l": "ATP + CoA + dodecanedioate <=> AMP + diphosphate + dodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297354", "l": "Acrosin Cleavage (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.98", "l": "\"4-hydroxy-3-polyprenylbenzoate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23158", "l": "(indol-3-yl)acetonitrile + H2O => (E)-(indol-3-yl)acetaldehyde oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43098", "l": "H(+) + N(1)-methylguanosine(2535) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2535) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77334", "l": "glyoxylate + L-ornithine <=> 5-amino-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036429", "l": "adenosylcobinamide kinase (ATP-specific) activity", "d": ["Catalysis of the reaction: adenosylcobinamide + ATP = adenosylcobinamide phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69199", "l": "ATP + L-glutamate + L-glutamyl-[beta-tubulin] <=> ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698026", "l": "FLT3 ITD- and STAT5-dependent BCL2L1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38462", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA <=> 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76730", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 7-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15248", "l": "a monoacylglycerol + H2O <=> a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57968", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.170", "l": "\"8-epi-inunolide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174255", "l": "Degradation multiubiquitinated Cyclin A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24010", "l": "ADP + H(+) + N(omega)-phosphohypotaurocyamine => ATP + hypotaurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985275", "l": "RUNX2 binds to SATB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35824", "l": "5,6,7,8-tetrahydromethanopterin + NAD(+) => 7,8-dihydromethanopterin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40307", "l": "A + decanedioyl-CoA = (2E)-decenedioyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28955", "l": "aldehydo-D-glucuronate(in) + H(+)(in) = aldehydo-D-glucuronate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58964", "l": "H2O + hexanal + O2 = H(+) + H2O2 + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69840", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426489", "l": "RISC binds inexactly matching target RNAs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418091", "l": "F2R binds ARRB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183126", "l": "Factor B binds to surface-associated C3b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050221", "l": "prostaglandin E2 9-reductase activity", "d": ["Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28939", "l": "H(+)(in) + xanthosine(in) = H(+)(out) + xanthosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75614", "l": "H2O + plasmodiophorol A <=> plasmodiophorol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66314", "l": "a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+) => an alpha-mannosylinositol-1-phosphoceramide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32394", "l": "(1R,2R,4R)-dihydrocarveol + NAD(+) <=> (1R,4R)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36194", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008523", "l": "sodium-dependent multivitamin transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202489", "l": "Oligomerization of Bcl10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030789", "l": "precorrin-3B C17-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16347", "l": "(3E,7E)-dolabella-3,7-dien-18-ol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25189", "l": "chloroacetate + H2O = chloride + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.50", "l": "\"pentachlorophenol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672019", "l": "Leucodopachrome, L-Dopaquinone transform to Dopachrome, L-Dopa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008667", "l": "2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity", "d": ["Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD+ = 2,3-dihydroxybenzoate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43471", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59287", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + H2O <=> D-glucose + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53305", "l": "AH2 + 2 ATP + 2 cob(II)alamin => A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022879", "l": "protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678998", "l": "Endosomal TLRs pass through the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604752", "l": "Initial activation of proMMP13 by MMP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004435", "l": "phosphatidylinositol phospholipase C activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53363", "l": "5,6-dihydrouridine(47) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(47) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23374", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine => ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23008", "l": "alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate", "d": [], "t": []}, {"i": "EC:3.2.1.93", "l": "\"alpha,alpha-phosphotrehalase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22874", "l": "CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen] => 2-oxoglutarate + L-prolyl-[collagen] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30249", "l": "O2 + 2 plastoquinol-9 => 2 H2O + 4 hnu + 2 plastoquinone-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000031", "l": "mannosylphosphate transferase activity", "d": ["Catalysis of the transfer of a mannosylphosphate group from one compound to another."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66482", "l": "gypsogenin 28-beta-D-glucoside + UDP => gypsogenin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866857", "l": "CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34932", "l": "glutathioselenol + NADPH => glutathione + hydrogenselenide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64950", "l": "dCDP + H(+) + phosphate => dCTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653786", "l": "USP43 deISGylates ISG:K164,ISG:K168-PCNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38959", "l": "a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2", "d": [], "t": []}, {"i": "EC:1.3.3.6", "l": "\"acyl-CoA oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047192", "l": "1-alkylglycerophosphocholine O-acetyltransferase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38886", "l": "a fatty acid + ATP + CoA <=> a fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446077", "l": "BP230 interacts with keretin K5/K14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4167511", "l": "HLCS biotinylates ACACB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047439", "l": "3-deoxy-D-manno-octulosonate aldolase activity", "d": ["Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76696", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione => (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59307", "l": "3'-phosphoadenylyl sulfate + firefly L-luciferin <=> adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614778", "l": "MAG gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60793", "l": "3 2-oxoglutarate + gibberellin A53 + 3 O2 => 3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2179413", "l": "Activated PKC-alpha  activate MMP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44607", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047209", "l": "coniferyl-alcohol glucosyltransferase activity", "d": ["Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433456", "l": "Recruitment of STATs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67528", "l": "(6Z)-octenoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.15.1.-", "l": "\"Acting on superoxide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27787", "l": "2-oxoglutarate + CoA + NAD(+) => CO2 + NADH + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15347", "l": "AMP + diphosphate + H(+) + L-tyrosyl-L-arginine => ATP + L-arginine + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30847", "l": "FAD + glutaryl-CoA + 2 H(+) = (2E)-butenoyl-CoA + CO2 + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68820", "l": "(2Z,6E)-farnesyl diphosphate + H2O = (6E)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685953", "l": "SIRT6 deacetylates RBBP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67927", "l": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate <=> 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42689", "l": "AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide => A + ergothioneine + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9840807", "l": "OPTN binds ATG9A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67213", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2 => (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71903", "l": "guanine + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-guanine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374337", "l": "Apelin receptor binds to apelin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31736", "l": "3-oxocholan-24-oyl-CoA + NAD(+) => 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29837", "l": "D-galactonate(out) + H(+)(out) => D-galactonate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14092", "l": "2-oxoglutarate + glycine <=> glyoxylate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375160", "l": "NCAM1 binds to ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60784", "l": "2-oxoglutarate + gibberellin A24 + O2 = CO2 + gibberellin A25 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3229181", "l": "CALM1:Ca2+ binds CNG channel (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19949", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.15", "l": "\"dihydropteroate synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668597", "l": "DNA polymerase:primase binds G-strand of the telomere (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15851", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate => 2 Fe(III)-[cytochrome c] + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43476", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 = 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54513", "l": "peregrinol diphosphate => (13R)-9,13-epoxylabd-14-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23715", "l": "NADP(+) + pregnan-21-ol <=> H(+) + NADPH + pregnan-21-al", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21046", "l": "(Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine => 24-methylidenelophenol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25075", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218814", "l": "PAK2 autophorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22724", "l": "a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.173", "l": "\"sterol 3beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120152", "l": "calcium-dependent outer dynein arm binding", "d": ["Binding to an outer dynein arm in the presence of calcium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70042", "l": "3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043834", "l": "trimethylamine methyltransferase activity", "d": ["Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15522", "l": "N-terminal glycyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoylglycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210292", "l": "Interaction of DAP12 and TREM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668904", "l": "Formation of the CTF18 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40590", "l": "H2O + octanedioyl-CoA <=> CoA + H(+) + octanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9038545", "l": "miR-613 binds to the 3'UTR of the NR1H3 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29676", "l": "glycerol(in) => glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369114", "l": "PRLR binds SHP2 (PTPN11) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672174", "l": "Ligand-independent dimerization of PDGFRA extracellular domain mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.90", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28607", "l": "L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851933", "l": "MET phosphorylates GAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3134800", "l": "STING dimerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58492", "l": "ATP + Fe(III)-enterobactin(out) + H2O = ADP + Fe(III)-enterobactin(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.17", "l": "\"ABC-type ferric enterobactin transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390059", "l": "HPO dimer binds to RASSF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202721", "l": "JAM2 binds JAM3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54352", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805285", "l": "PLK3 phosphorylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72819", "l": "L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) = L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-417829", "l": "P2RY12 binds ADP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47292", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10833", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O => 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852331", "l": "GTSE1 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474266", "l": "Formation of collagen fibrils (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65082", "l": "asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane D + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75598", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 11-hydroxy-12,13-epoxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59606", "l": "H2O2 + N-(4-aminobutyl)-3-aminopropanal + NH4(+) => H2O + O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65915", "l": "3-hydroxy-L-kynurenine + pyruvate <=> 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23886", "l": "1-methylnicotinamide + S-adenosyl-L-homocysteine => nicotinamide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247960", "l": "Activation of p38 MAPK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21062", "l": "CoA + N-(3,4-dichlorophenyl)malonamate => 3,4-dichloroaniline + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757686", "l": "SERPINA6 binds PREDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46701", "l": "(R)-lipoate + GTP + H(+) => (R)-lipoyl-GMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.23", "l": "\"nitroarene dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060698", "l": "endoribonuclease inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of endoribonuclease."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374173", "l": "AGT(34-41) binds to AGTR1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698988", "l": "Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30045", "l": "iminosuccinate + succinate => fumarate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41900", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] = 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161563", "l": "PGJ2 is isomerised to delta12-PGJ2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008430", "l": "selenium binding", "d": ["Binding to a selenium (Se) ion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019959", "l": "interleukin-8 binding", "d": ["Binding to interleukin-8."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607745", "l": "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72697", "l": "Start codon recognition (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18034", "l": "benzoate + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26102", "l": "(2R)-homocitrate => cis-homoaconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16098", "l": "acetylpyruvate + H2O => acetate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10870", "l": "a triacyl-sn-glycerol + CoA => a 1,2-diacyl-sn-glycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604712", "l": "Initial activation of proMMP7 by trypsin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928625", "l": "PAKs autophosphorylate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0019784", "l": "deNEDDylase activity", "d": ["An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202248", "l": "Phosphorylation of PLC-gamma1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080014", "l": "thalianol hydroxylase activity", "d": ["Catalysis of the reaction: a thalianol = a thalian-diol. This reaction is the addition of a hydroxyl group to thalianol ((13R,14R,17E)-podioda-8,17,21-trien-3beta-ol) to create a thalian-diol ((13R,14R,17E)-podioda-8,17,21-trien-3beta,X-diol), where the hydroxyl group may be attached at one of several different available carbons in ring B or C of thalianol, indicated by the X."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72691", "l": "Formation of the 43S pre-initiation complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59321", "l": "D-cellobiono-1,5-lactone + H2O => 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782820", "l": "USP17 deubiquitinates SUDS3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607747", "l": "TRAF6 binds MALT1 oligomers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61560", "l": "gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429992", "l": "PARN deadenylates mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18552", "l": "[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.42", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47447", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + CoA <=> (5Z)-tetradecenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009488", "l": "IL34 binds CSF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683964", "l": "ATM phosphorylates EYA1-4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73877", "l": "(R)-adrenaline(in) => (R)-adrenaline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835385", "l": "DUS2 binds PKR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714483", "l": "RAC2 translocates to the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38882", "l": "a fatty acid(in) <=> a fatty acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36956", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA => (9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55092", "l": "D-fructose + UDP-alpha-D-glucose = H(+) + sucrose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77805", "l": "2-dehydro-D-glucose + glycine => 2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]acetate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662613", "l": "MT3 exchanges zinc for copper (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64288", "l": "2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] = cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17430", "l": "NAD(+) + trans-4-hydroxycyclohexanecarboxylate => 4-oxocyclohexanecarboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71013", "l": "L-isoleucine(out) + L-phenylalanine(in) => L-isoleucine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21297", "l": "D-galactose + NAD(+) => D-galactono-1,4-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613644", "l": "SOX10-dependent POU3F1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9824732", "l": "G or G analog binds C-ter TLR7 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66282", "l": "H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP => solanidine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70115", "l": "6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30199", "l": "2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61881", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635842", "l": "ULK3 phosphorylates GLI (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48835", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19479", "l": "3,4-dihydroxybenzoate + H2O + NADP(+) => 4-hydroxybenzoate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72420", "l": "(E)-4-coumarate + ATP + H(+) => (E)-4-coumaroyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11532", "l": "glycine + H2O + O2 = glyoxylate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13661", "l": "H2O + N-formimidoyl-L-aspartate = N-formyl-L-aspartate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.3.5", "l": "\"formimidoylaspartate deiminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60851", "l": "a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein] <=> a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22233", "l": "H(+) + NADPH + presqualene diphosphate => diphosphate + NADP(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42275", "l": "3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] <=> 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57019", "l": "3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372542", "l": "Loading of dopamine into synaptic veiscles (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0160185", "l": "phospholipase C activator activity", "d": ["Binds to and increases the activity of the enzyme phospholipase C."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156910", "l": "Formation of eEF1B complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222093", "l": "BRD7 binds TP53 and EP300 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.42", "l": "\"FMN reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24943", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NADP(+) = (4S)-4-hydroxy-L-glutamate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39842", "l": "a 2,3-diacyl-sn-glycerol + an acyl-CoA <=> a triacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675194", "l": "Activated MAPK phosphorylates RAF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31711", "l": "beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.152", "l": "\"beta-amyrin 11-oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19394", "l": "L-lysine + pyruvate => (S)-2-amino-6-oxohexanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9725855", "l": "NR3C2 binds NR3C2 antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59922", "l": "(2E)-octenoate + 2 H(+) + NADH => (2E)-octenal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44692", "l": "a fatty acyl-CoA + hexadecasphinganine = CoA + H(+) + N-acylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39791", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76506", "l": "4-O-beta-D-glucosyl-trans-ferulate + H2O <=> 4-O-beta-D-glucosyl-vanillin + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53819", "l": "hydrogen sulfide + O-succinyl-L-serine <=> L-cysteine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189488", "l": "UROS transforms HMB to URO3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48586", "l": "2 lipoxin A4 => 2 H2O + 2 leukotriene A4 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928620", "l": "PAK1 autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678749", "l": "IMPDH tetramers binds IMPDH inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380574", "l": "Dopamine synaptic vesicle docking and priming (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16329", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011300", "l": "ZSWIM8 ubiquitinates ROBO3.1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.198", "l": "\"alpha-selinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53384", "l": "5,10-methylenetetrahydromethanopterin + NAD(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166792", "l": "Conversion of C2 into C2a and C2b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-982765", "l": "Growth hormone forms dimers and oligomers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042292", "l": "URM1 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40039", "l": "2 ATP + 2 L-glutamate + N-acetyl-L-aspartate = 2 ADP + 2 H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate + 2 phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.42", "l": "\"N-acetylaspartylglutamylglutamate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63610", "l": "apelin-16 + L-phenylalanine => apelin-17 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69014", "l": "5beta-androstane-3beta,17beta-diol + NADP(+) => 5beta-dihydrotestosterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12481", "l": "5-aminolevulinate + pyruvate => 4,5-dioxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696266", "l": "RND2 binds effectors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033550", "l": "MAP kinase tyrosine phosphatase activity", "d": ["Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340214", "l": "CYGB binds O2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54402", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26431", "l": "(+)-copalyl diphosphate + H2O => diphosphate + phyllocladan-16alpha-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66658", "l": "Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in) => Cu(2+)(out) + L-ascorbate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33649", "l": "(9Z)-hexadecenoyl-CoA + AMP + diphosphate => (9Z)-hexadecenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548890", "l": "Removal of the third glucose by glucosidase II and release from the chaperone (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212356", "l": "Formation of CSL-NICD coactivator complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428123", "l": "KDSR reduces 3-ketosphingoid (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662096", "l": "Exocytosis of glutamate from cochlear inner hair cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047541", "l": "2-furoate-CoA ligase activity", "d": ["Catalysis of the reaction: 2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31812", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + viridiflorene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030973", "l": "molybdate ion binding", "d": ["Binding to a molybdate ion (MoO4 2-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664879", "l": "ATM:PEX5 binds ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69384", "l": "(R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) = (3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]", "d": [], "t": []}, {"i": "EC:2.1.1.383", "l": "\"L-carnitine--corrinoid protein Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102325", "l": "2,2',3-trihydroxybiphenyl monooxygenase activity", "d": ["Catalysis of the reaction: biphenyl-2,2',3-triol + O2 + NADH + H+ = 2,2',3,3'-tetrahydroxybiphenyl + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59509", "l": "fumarate + L-cysteinyl-[protein] => S-(2-succinyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54641", "l": "(+)-copalyl diphosphate => (12E)-labda-8(17),12,14-triene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018901", "l": "5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097726", "l": "LEM domain binding", "d": ["Binding to a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655248", "l": "Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74228", "l": "H2O + L-threonyl-tRNA(Ile) => L-threonine + tRNA(Ile)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63911", "l": "ATP + H2O + pravastatin(in) <=> ADP + H(+) + phosphate + pravastatin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73635", "l": "CTP(out) + dGMP(in) = CTP(in) + dGMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3221982", "l": "BANP binds TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25421", "l": "3-hydroxybenzoyl-CoA + AH2 + 2 ATP + 2 H2O => 3-hydroxycyclohexa-1,5-diene-1-carbonyl-CoA + A + 2 ADP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46823", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47466", "l": "(2E,5Z)-tetradecadienoyl-CoA => (3E,5Z)-tetradecadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32747", "l": "ethanolamine(in) = ethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11606", "l": "[O(7),N-diacetyl-alpha-D-neuraminosyl-(2->8)](n) + n CoA => [N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + n acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804100", "l": "HMGB1 binds LPS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201472", "l": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49973", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37079", "l": "2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44194", "l": "2-methylhexadecanoyl-CoA + AMP + diphosphate => 2-methylhexadecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39837", "l": "1-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060228", "l": "phosphatidylcholine-sterol O-acyltransferase activator activity", "d": ["Binds to and increases the activity of phosphatidylcholine-sterol O-acyltransferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15669", "l": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37291", "l": "H2O + L-alanyl-L-leucine = L-alanine + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49399", "l": "20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36717", "l": "an N-tetracosenoylsphinganine + CoA + H(+) => sphinganine + tetracosenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38554", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2 <=> (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63122", "l": "(11Z)-eicosenoate + NH4(+) => (11Z)-eicosenamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75961", "l": "(S)-3-O-demethylscoulerine + CO2 + formaldehyde + succinate => (S)-scoulerine + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63735", "l": "UDP-alpha-D-glucuronate + zolasartan <=> UDP + zolarsartan O-beta-D-glucuronoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34671", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine = 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607736", "l": "MALT1 oligomerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33626", "l": "ATP + CoA + dodecanoate <=> AMP + diphosphate + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74371", "l": "a carboxylate(out) + nicotinate(in) = a carboxylate(in) + nicotinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51955", "l": "(E)-2-methylpropanal oxime + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-2-methylpropanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71262", "l": "2 Na(+)(out) + phosphate(out) <=> 2 Na(+)(in) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684043", "l": "Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787525", "l": "TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71874", "l": "(S)-3-hydroxybutanoate(out) + H(+)(out) <=> (S)-3-hydroxybutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956659", "l": "ABL1 phosphorylates YAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74771", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine = 3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69151", "l": "H2O + O2 + spermine <=> H2O2 + NH4(+) + spermine monoaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5220959", "l": "TDG excises 5-formylcytosine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29351", "l": "Zn(2+)(in) = Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70241", "l": "PCK1 phosphorylates OA to yield PEP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50895", "l": "a menaquinone + 2 H(+) + hydrogen sulfide + sulfite <=> a menaquinol + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33434", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate <=> (3E)-2-oxohex-3-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50380", "l": "3 H(+) + 3 malonyl-CoA = 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.253", "l": "\"phloroglucinol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805126", "l": "AURKB phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67462", "l": "AH2 + oxaloacetate => (R)-malate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76093", "l": "(11R)-19-oxocarlactone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (11R)-19-hydroxycarlactone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44376", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31401", "l": "all-trans-4,4'-diapo-zeta-carotene + FADH2 => all-trans-4,4'-diapophytofluene + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50653", "l": "2-(3-methylsulfanyl)propylmalate => 2-(2-methylsulfanyl)propylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78605", "l": "(2E)-octadecenoyl-CoA + H2O => (3S)-hydroxyoctadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374662", "l": "Translocation of Ezrin to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022315", "l": "MECP2 binds DGCR8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59166", "l": "AMP + diphosphate + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] => ATP + hexadecanoate + holo-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20476", "l": "(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] <=> AMP + 2 H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56923", "l": "a medium chain fatty acid + ATP + H(+) <=> a medium-chain fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944262", "l": "Association of procollagen type X (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635859", "l": "GLI:SUFU dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36036", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-976768", "l": "Factor H binds to C3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43798", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045507", "l": "interleukin-25 receptor activity", "d": ["Combining with interleukin-25 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807242", "l": "25(OH)D translocates from ER membrane to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37242", "l": "2',3'-cyclophospho-UMP + H2O <=> H(+) + uridine 2'-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55953", "l": "an inositol-1-phosphoceramide + GDP-alpha-D-mannose => a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49280", "l": "FADH2 + O2 + phenol = catechol + FAD + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.20", "l": "\"phenol 2-monooxygenase (FADH2)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9842641", "l": "Active LTK receptor binds SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019161", "l": "diamine transaminase activity", "d": ["Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45619", "l": "H2O + N-hexanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0031956", "l": "medium-chain fatty acid-CoA ligase activity", "d": ["Catalysis of the reaction: a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2429719", "l": "MCPH1 sequesters condensin II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71163", "l": "HPD dioxygenates HPP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58241", "l": "H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] => ADP-D-ribose + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29815", "l": "ATP + H2O + L-proline(out) = ADP + H(+) + L-proline(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168947", "l": "Ligand binds to TLR10 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77122", "l": "1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,2,6-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25743", "l": "H(+) + N,N-dihydroxy-L-pentahomomethionine = (E)-8-(methylsulfanyl)octanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961934", "l": "CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51662", "l": "an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+) => an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011543", "l": "DCA binds PDK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373887", "l": "lactate + H+ [extracellular] <=> lactate + H+ [cytosol] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60667", "l": "H2O + NADPH <=> NADH + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050082", "l": "maltose phosphorylase activity", "d": ["Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45735", "l": "D-ribulose 5-phosphate + L-tyrosine <=> (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70982", "l": "FH tetramer hydrates fumarate to L-malate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14796", "l": "2-hydroxyadipate + NAD(+) <=> 2-oxoadipate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43980", "l": "H(+) + hexadecanoate + NADPH + O2 = 15-hydroxyhexadecanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66082", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminopentanoate => 2-oxopentanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78547", "l": "Rb(+)(in) = Rb(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64049", "l": "(13Z)-docosenoyl-CoA + sphinganine => CoA + H(+) + N-(13Z-docosenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844955", "l": "CLN3 transports GalCer to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18300", "l": "a phtalamide + H2O <=> a primary amine + phthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27644", "l": "adenine + alpha-D-ribose 1-phosphate => adenosine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195318", "l": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35355", "l": "3-hydroxyisopentadecanoyl-CoA = (2E)-13-methyltetradecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052828", "l": "inositol-3,4-bisphosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60423", "l": "H2O + triglucosyl-enterobactin <=> [N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28122", "l": "ATP + di-trans,octa-cis-undecaprenol = ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68648", "l": "2 L-cysteine = H(+) + hydrogen sulfide + L-lanthionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141423", "l": "Binding of the MCC complex to the APC/C complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32404", "l": "(1R,2S,4R)-neodihydrocarveol + NAD(+) => (1R,4R)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58683", "l": "A + FADH2 <=> AH2 + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34109", "l": "1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA => glycine + H(+) + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372529", "l": "Release of acetylcholine at the synapse (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12507", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NAD(+) <=> 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109860", "l": "MAP2K1 phosphorylates MAPK3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15671", "l": "a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + ADP + H(+) => a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19933", "l": "alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.10", "l": "\"glucose-1-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27947", "l": "dopamine + H2O + O2 => 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77920", "l": "a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA + H2O => 2-deoxy-D-ribose 5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032775", "l": "YAP1 binds TEAD1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17773", "l": "ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)", "d": [], "t": []}, {"i": "EC:6.1.1.16", "l": "\"cysteine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853792", "l": "RET tyrosine phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391211", "l": "Trace amine-associated receptors can bind trace amines (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49840", "l": "(-)-dehydrodiconiferyl acid + 2 a quinone + H2O = (-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9817575", "l": "ERO1B oxidizes P4HB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11819", "l": "alpha-D-glucose 6-phosphate <=> beta-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.280", "l": "\"(aminoalkyl)phosphonate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29946", "l": "2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) <=> 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864569", "l": "WWOX binds TFAP2C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70376", "l": "3-oxosphinganine + dodecanoyl-CoA => CoA + H(+) + N-dodecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378952", "l": "Thyrotropin is a heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23243", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54443", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + H(+) <=> a 4-H-anthocyanidin with a 3-hydroxy group + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28684", "l": "L-aspartate + ubiquinone-8 => iminosuccinate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74262", "l": "H2O + L-homoseryl-tRNA(Lys) <=> H(+) + L-homoserine + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390930", "l": "5-HT2 receptor can bind serotonin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43039", "l": "L-cysteine <=> 2-aminoprop-2-enoate + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43465", "l": "H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] => (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.33584335509623", "identifiers": [{"i": "GO:0005230", "l": "extracellular ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012835", "l": "GDIs block activation of RHOA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871373", "l": "BMX phosphorylates RUFY1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25261", "l": "2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54247", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73237", "l": "2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+) => 2,6-dichlorobenzoquinone + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77476", "l": "acetyl-CoA + tetrahydroanabasine => ammodendrine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36850", "l": "FAD + L-threonyl-[protein] <=> AMP + FMN-L-threonyl-[protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350058", "l": "Formation of CSL NCOR corepressor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12944", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990601", "l": "5' overhang single-stranded DNA endodeoxyribonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within 5' overhang single-stranded deoxyribonucleic acid by creating internal breaks."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68636", "l": "(2E)-geranyl diphosphate = diphosphate + sabinene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005132", "l": "type I interferon receptor binding", "d": ["Binding to an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58938", "l": "all-trans-lycopaoctaene + 2 diphosphate + NAD(+) => 2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.113", "l": "\"alpha-1,4-glucan-protein synthase (ADP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983153", "l": "E1 mediated ubiquitin activation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9750942", "l": "USP14 deubiquitinates NLRC5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730903", "l": "Oligomerization of TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41317", "l": "1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36781", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate => 2-oxoglutarate + GDP-alpha-D-perosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987039", "l": "JAK1 binds IL20RA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45826", "l": "CO2 + ethanolamine => H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839053", "l": "AFG3L2:SPG7 binds SMDT1 (EMRE) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34409", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate => 3 ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863718", "l": "AGFG1 binds VAMP7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698932", "l": "Assembly of HCMV Procapsid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73415", "l": "(-)-cyclopenine = H(+) + methyl isocyanate + viridicatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33954", "l": "ribostamycin + UDP-N-acetyl-alpha-D-glucosamine <=> 2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59003", "l": "H2O + O2 + propanal <=> H(+) + H2O2 + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53618", "l": "(+)-isoafricanol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24965", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitetrol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45055", "l": "(2E)-butenoyl-CoA + (R)-carnitine <=> CoA + O-(2E)-butenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32139", "l": "ATP + CoA + malonate = AMP + diphosphate + malonyl-CoA", "d": [], "t": []}, {"i": "EC:6.2.1.76", "l": "\"malonate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607723", "l": "SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47291", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33549", "l": "H(+) + hexadecanoate + lanosterol => H2O + lanosteryl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034522", "l": "cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity", "d": ["Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene = 1,2-dihydroxy-8-carboxynaphthalene + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53539", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-379387", "l": "COMT transfers Met to DA to form 3MT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20710", "l": "ADP + D-erythritol 4-phosphate + H(+) => ATP + erythritol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38511", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43625", "l": "2-aminomalonate semialdehyde + H(+) => aminoacetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37151", "l": "(9Z)-octadecenoyl-CoA + 1-heptadecanoyl-sn-glycero-3-phosphate = 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985812", "l": "NCK2 binds to ROBO1,(ROBO2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65017", "l": "chlorothalonil + H2O => 4-hydroxychlorothalonil + chloride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047537", "l": "2-aminohexanoate transaminase activity", "d": ["Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70999", "l": "(S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64063", "l": "(S)-phenylacetylcarbinol + NAD(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48514", "l": "ADP + H(+) + phosphate + phosphinate(in) => ATP + H2O + phosphinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21827", "l": "2-oxoglutarate + L-aspartate <=> L-glutamate + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55714", "l": "(9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+) => 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33694", "l": "2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate <=> (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16709", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan", "d": [], "t": []}, {"i": "EC:1.14.16.4", "l": "\"tryptophan 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57943", "l": "Fe-coproporphyrin III + H(+) + H2O2 <=> CO2 + 2 H2O + harderoheme III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42776", "l": "adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.180", "l": "\"16S rRNA (adenine(1408)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0003940", "l": "L-iduronidase activity", "d": ["Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40019", "l": "ent-copalyl diphosphate + H2O = (-)-ent-copalol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632759", "l": "TP53 binds the SCO2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211904", "l": "CYP4F12 18-hydroxylates ARA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73140", "l": "lithocholate(out) => lithocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40516", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate => (2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36703", "l": "(2S,5S)-5-carboxymethylproline + ATP = (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.3.6", "l": "\"carbapenam-3-carboxylate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76933", "l": "acetoin + H(+) + NADPH + NH4(+) => 3-aminobutan-2-ol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936963", "l": "IRAK2 induces TRAF6 oligomerization (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25896", "l": "H(+) + malonate = acetate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.88", "l": "\"biotin-independent malonate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102087", "l": "N-benzoyl-L-glutamate synthetase activity", "d": ["Catalysis of the reaction: benzoate + L-glutamate + ATP = H+ + N-benzoyl-L-glutamate + AMP + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9854415", "l": "ACAT1 tetramer acetylates IDH2 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114275", "l": "Oligomerization of BAX at the mitochondrial membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62521", "l": "a cytidine in rRNA + S-adenosyl-L-methionine => an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64787", "l": "S-ethyl-L-cysteine <=> 2-aminoprop-2-enoate + ethanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34549", "l": "ADP + cob(II)yrinate c monoamide + H(+) + L-glutamate + phosphate => ATP + cob(II)yrinate + H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65897", "l": "glyoxylate + L-kynurenine => glycine + H2O + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030604", "l": "1-deoxy-D-xylulose-5-phosphate reductoisomerase activity", "d": ["Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38256", "l": "(S)-malate + succinyl-CoA => (S)-malyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53018", "l": "chloride + glutathione disulfide + H(+) + hydroquinone => chlorohydroquinone + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102708", "l": "S-adenosyl-L-methionine:N-methyl-beta-alanine N-methyltransferase activity", "d": ["Catalysis of the reaction: N-methyl-beta-alanine + S-adenosyl-L-methionine = H+ + N,N-dimethyl-beta-alanine + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806405", "l": "TP53 stimulates PMS2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835009", "l": "PRKN binds p-S-Ub:MOM proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66088", "l": "L-kynurenine + oxaloacetate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30369", "l": "adenosylcob(III)alamin + phosphate => adenosylcob(III)alamin 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35311", "l": "3-hydroxyisoheptadecanoyl-CoA + NADP(+) = 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55688", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O = 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102036", "l": "methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity", "d": ["Catalysis of the reaction: a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] = an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52117", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA => 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64081", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036077", "l": "Defective HYAL1 does not hydrolyse (HA)50 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035718", "l": "macrophage migration inhibitory factor binding", "d": ["Binding to the cytokine, macrophage migration inhibitory factor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58826", "l": "aureothin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + luteothin + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170023", "l": "ionotropic sweet taste receptor activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific soluble sweet compound has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635859", "l": "GLI:SUFU dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53320", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.349", "l": "\"mannosyl-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873918", "l": "Transphosphorylation of JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10834", "l": "6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphate + H(+) => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46362", "l": "1-acyl-2-[(R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + H2O => 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000319", "l": "sulfite transmembrane transporter activity", "d": ["Enables the transfer of sulfite ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23805", "l": "N-acetyl-alpha-D-glucosamine 1-phosphate => N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32354", "l": "3 S-adenosyl-L-methionine + tricetin <=> 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.260", "l": "\"rRNA small subunit pseudouridine methyltransferase Nep1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53692", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O = H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32289", "l": "(2S)-2-isopropylmalate => (2R,3S)-3-isopropylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44143", "l": "CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate <=> acetyl-CoA + CO2 + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41820", "l": "butanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54506", "l": "beta-hexaprene + diphosphate => all-trans-hexaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65921", "l": "L-kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66033", "l": "alpha-D-mannose 1-phosphate + GDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57055", "l": "3-oxoisoapionate + H(+) <=> CO2 + L-erythrulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21149", "l": "indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose => 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73240", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether => H(+) + ladanein + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39664", "l": "a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9856465", "l": "MLPH/MYRIP bind GGC-RAB27A and MYO5A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20428", "l": "2-oxoglutarate + ATP + hydrogencarbonate <=> (S)-oxalosuccinate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619376", "l": "CAMK1 binds calmodulin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807585", "l": "BPI binds LPS on the bacterial surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159795", "l": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67568", "l": "3'-phosphoadenylyl sulfate + taurochenodeoxycholate = adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13472", "l": "A + H2O + thymine <=> 5-methylbarbiturate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015344", "l": "siderophore uptake transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52479", "l": "estrone + UDP-alpha-D-glucuronate <=> estrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79103", "l": "L-histidine + taurocholate = L-histidocholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42442", "l": "H(+) + iminosuccinate + NADH => L-aspartate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140221", "l": "Transactivation of BBC3 (PUMA) by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26478", "l": "1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55820", "l": "a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42325", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n) => 3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72672", "l": "The 60S subunit joins the translation initiation complex  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18012", "l": "glutaryl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005112", "l": "Notch binding", "d": ["Binding to a Notch (N) protein, a surface receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2430535", "l": "MASTL phosphorylates ENSA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11118", "l": "an N-acetylalkane-alpha,omega-diamine + CoA + H(+) => acetyl-CoA + an alkane-alpha,omega-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3249378", "l": "STING recruits TBK1 and STAT6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62659", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate <=> 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56613", "l": "L-cysteinyl-[protein] + NAD(+) => H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65450", "l": "CoA + ethyl butanoate => butanoyl-CoA + ethanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44021", "l": "H2O + NAD(+) + octadecanal => 2 H(+) + NADH + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734475", "l": "PPARA binds fibrates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047654", "l": "alliin lyase activity", "d": ["Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351208", "l": "Spermidine  => N-acetylated spermidine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162657", "l": "Inactivation of Myt1 kinase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19193", "l": "A + all-trans-13,14-dihydroretinol = AH2 + all-trans-retinol", "d": [], "t": []}, {"i": "EC:1.3.99.23", "l": "\"all-trans-retinol 13,14-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769394", "l": "AKT phosphorylates CBY1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21724", "l": "a nitrile + 2 H2O = a carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25242", "l": "(S)-2-ureidoglycine + H2O => (S)-ureidoglycolate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623280", "l": "PCK1 gene expression is stimulated by FOXO1:PPARGC1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73208", "l": "sulfate(out) + sulfite(in) => sulfate(in) + sulfite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371582", "l": "HSBP1 binds HSF1 trimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9676254", "l": "Formation of the MLL3 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696822", "l": "AKR1B15 reduces EST17b to E1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38575", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419843", "l": "CALCA(83-119) binds CALCR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36012", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21504", "l": "acetoin + aldehydo-D-ribose 5-phosphate = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde", "d": [], "t": []}, {"i": "EC:2.2.1.4", "l": "\"acetoin--ribose-5-phosphate transaldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70552", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose => 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2981040", "l": "COLEC12:ligand is endocytosed (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102319", "l": "2-deoxystreptamine N-acetyl-D-glucosaminyltransferase activity", "d": ["Catalysis of the reaction: 2-deoxystreptamine(2+) + UDP-N-acetyl-alpha-D-glucosamine = H+ + 2'-N-acetylparomamine(2+) + UDP(3-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19987", "l": "H(+) + NADH + S-formylglutathione => NAD(+) + S-(hydroxymethyl)glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33953", "l": "2'''-acetyl-6'''-hydroxyneomycin C + H(+) + UDP => ribostamycin + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621242", "l": "CITED2 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51386", "l": "CoA + H(+) + N-hexadecanoyl-serotonin => hexadecanoyl-CoA + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30859", "l": "dITP + H2O = dIDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592362", "l": "Activation of proMMP7 by MMP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706315", "l": "Active FLT3 binds to SH2B3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50565", "l": "acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-500717", "l": "Activation of GRIK3 homomer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62901", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197963", "l": "DHFR2 reduces FOLA to DHF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50729", "l": "(Z)-(4-hydroxyphenyl)acetaldehyde oxime => 4-hydroxyphenylacetonitrile + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50051", "l": "ATP + cholate(in) + H2O <=> ADP + cholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61984", "l": "H(+) + NADH + ubiquinone-10 = NAD(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37786", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50454", "l": "prostaglandin E3 => prostaglandin H3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851933", "l": "MET phosphorylates GAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607023", "l": "factor IXa associates with cell membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72574", "l": "dehydroepiandrosterone 3-sulfate(in) + pentanoate(out) <=> dehydroepiandrosterone 3-sulfate(out) + pentanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12948", "l": "2'-hydroxybiphenyl-2-sulfinate + H2O <=> biphenyl-2-ol + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50075", "l": "ATP + H2O + tauroursodeoxycholate(in) <=> ADP + H(+) + phosphate + tauroursodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202604", "l": "Formation of a heteromeric BMP receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76565", "l": "an N-acylsphing-14Z-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O => an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78144", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => a 1,3-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617859", "l": "Retinoic acid activates HOXB4 chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.13", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32894", "l": "(1S,5S)-alpha-pinene + H(+) + NADH + O2 <=> alpha-pinene oxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74839", "l": "UDP(in) + UDP-alpha-D-glucuronate(out) = UDP(out) + UDP-alpha-D-glucuronate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22742", "l": "a D-hexose 6-phosphate + ADP + H(+) => a D-hexose + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24766", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate => UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003858", "l": "3-hydroxybutyrate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47697", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34634", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.371", "l": "\"polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-alpha-mannosylpolymerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33765", "l": "a 2,3-saturated acyl-CoA + NADP(+) => a (2E)-enoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28776", "l": "dinoflagellate luciferin + O2 => H(+) + H2O + hnu + oxidized dinoflagellate luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10701", "l": "H2O + limonene 1,2-epoxide => limonene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445699", "l": "ATP Hydrolysis By Myosin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9860290", "l": "TASL recruits IRF5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59807", "l": "L-phenylalanine <=> D-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64281", "l": "(S)-1-phenylethylamine + pyruvate => acetophenone + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30578", "l": "3 menaquinone-8 + protoporphyrinogen IX <=> 3 menaquinol-8 + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60756", "l": "(1R,3R)-chrysanthemoyl-CoA + (Z,S)-cinerolone = cinerin I + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785607", "l": "FANCM binds FAAP24 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12214", "l": "9H-fluoren-9-one + H(+) + NADPH => 9H-fluoren-9-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805426", "l": "CARD8 binds CASP9(1-416) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42012", "l": "cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44359", "l": "nogalaviketone <=> methyl nogalonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22128", "l": "(1S,2R,4S)-borneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.227", "l": "\"(-)-borneol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78568", "l": "acetyl-CoA + docosanoyl-CoA => 3-oxotetracosanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52184", "l": "(E)-(indol-3-yl)acetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = 1-aci-nitro-2-(1H-indol-3-yl)ethane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16950", "l": "myo-inositol + NAD(+) => H(+) + NADH + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32110", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine <=> H(+) + pterostilbene + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030273", "l": "melanin-concentrating hormone receptor activity", "d": ["Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667965", "l": "ANKLE2 binds PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48715", "l": "2 Fe(2+) + 2 H(+) + H2O2 <=> 2 Fe(3+) + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449855", "l": "IL10 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14536", "l": "creatinine + H2O <=> creatine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760510", "l": "LARP1 binds SARS-CoV-2 RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46728", "l": "(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44178", "l": "a 3-acyl-sn-glycerol + a fatty acid + H(+) => a 2,3-diacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769383", "l": "CBY1 binds beta-catenin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2301205", "l": "SETD8 monomethylates histone H4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30727", "l": "dATP + pyruvate = dADP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64124", "l": "H2O + N-hexadecanoyl-L-phenylalanine = hexadecanoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174058", "l": "Degradation of multiubiquitinated Cdh1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52253", "l": "a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53625", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + tsukubadiene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16763", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+) => chlorohydroquinone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15405", "l": "(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) = [(3R)-hydroxybutanoate](n+1) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65312", "l": "an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.293", "l": "\"meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62675", "l": "a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine <=> an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794352", "l": "Basolateral transport of Cipro into intestinal cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21409", "l": "H2O + L-phenylalanine + NAD(+) => 3-phenylpyruvate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49760", "l": "EDTA + FMNH2 + O2 = ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42178", "l": "(9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37598", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9856465", "l": "MLPH/MYRIP bind GGC-RAB27A and MYO5A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72524", "l": "1,6-dihydroxyphenazine + S-adenosyl-L-methionine => 1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625426", "l": "Retrograde IFT (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67734", "l": "a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA => uridylyl-uridylyl-ribonucleotide-RNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428205", "l": "ACER2 hydrolyzes ceramide (Golgi) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008973", "l": "phosphopentomutase activity", "d": ["Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848812", "l": "HIF1A,EPAS1 bind PTK6 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63552", "l": "angiotensin-(1-7) + H2O = angiotensin-(1-5) + L-histidyl-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65259", "l": "AH2 + O2 + verruculide C <=> A + H2O + verruculide C epoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791285", "l": "TP53 binds the BID gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004982", "l": "N-formyl peptide receptor activity", "d": ["Combining with an N-formyl peptide to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53507", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27683", "l": "ATP + dTDP => ADP + dTTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.40", "l": "\"anthraniloyl-CoA monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725357", "l": "NPM1-ALK-dependent CEBPB gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67067", "l": "AH2 + asnovolin K <=> A + asnovolin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.22", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983150", "l": "Proteasomal cleavage of substrate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913456", "l": "Interleukin-5 receptor alpha subunit binds Interleukin-5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46072", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADH = hexadecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39646", "l": "(2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH <=> (18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944247", "l": "Association of procollagen type VI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434633", "l": "PIP2 binds inhibiting VAV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74747", "l": "Dephosphorylation of p-Y-IRS1,p-Y-IRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67311", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one <=> (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49610", "l": "2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH => 2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66626", "l": "(25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50694", "l": "ADP + alpha-maltose 1-phosphate + H(+) => ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63309", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58882", "l": "4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.41", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103028", "l": "murein hydrolase activity", "d": ["Catalysis of the reaction: a peptidoglycan dimer (generic) = a lipid II + GlcNAc-1,6-anhydro-MurNAc-pentapeptide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357483", "l": "RAC1 binds PAK1-3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34285", "l": "2 L-dopa => 2 L-tyrosine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63894", "l": "AMP + D-tryptophan + diphosphate + H(+) => ATP + H2O + L-tryptophan", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9660192", "l": "VDR agonists bind VDR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46421", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48608", "l": "A + a 2,3-saturated acyl-CoA = a 2,3-dehydroacyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73572", "l": "(E,E)-piperate + ATP + CoA => (E,E)-piperoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21685", "l": "(R)-beta-alanopine + H2O + NAD(+) => beta-alanine + H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110215", "l": "Cleavage of uracil by UNG glycosylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71479", "l": "H2O + neurotensin = L-tyrosyl-L-isoleucyl-L-leucine + neurotensin(1-10)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28616", "l": "(2S)-2-methylbutanenitrile + H2O => (1Z,2S)-2-methylbutanal oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981157", "l": "Glucosylation of collagen propeptide hydroxylysines (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45408", "l": "(2E)-dodecenoyl-CoA + H(+) + NADH = dodecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9866217", "l": "HCCS inserts heme into cytochrome c (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875451", "l": "MET phosphorylates CBL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67002", "l": "3 CO2 + 4 CoA + phlorisobutanophenone => 2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.329435990110298", "identifiers": [{"i": "GO:0016879", "l": "ligase activity, forming carbon-nitrogen bonds", "d": ["Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}, {"i": "EC:6.3.-.-", "l": "\"Forming carbon-nitrogen bonds\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.70", "l": "\"aculeacin-A deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73669", "l": "(E,E)-piperlonguminine + CoA + H(+) => (E,E)-piperoyl-CoA + 2-methylpropan-1-amine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52474", "l": "16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17beta-estriol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37693", "l": "1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35257", "l": "ADP + H(+) + lipid A-core(out) + phosphate => ATP + H2O + lipid A-core(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71216", "l": "2 Na(+)(out) + thiocyanate(out) => 2 Na(+)(in) + thiocyanate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21743", "l": "2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol <=> [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047077", "l": "Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity", "d": ["Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34782", "l": "a 3alpha-hydroxysteroid + NAD(+) <=> a 3-oxosteroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635102", "l": "GPR161 is internalized (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61868", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53333", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 => 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45091", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20199", "l": "[heparan-N-sulfate](n) => [heparosan-N-sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63378", "l": "an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42586", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57594", "l": "(2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10027", "l": "L-lysyl-[histone] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29353", "l": "Zn(2+)(out) => Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75244", "l": "FASL binds FAS Receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033776", "l": "phenylacetone monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + phenylacetone = benzyl acetate + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40436", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130286", "l": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047805", "l": "cytidylate cyclase activity", "d": ["Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49354", "l": "2'-hydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73050", "l": "guanidinoacetate(in) <=> guanidinoacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18864", "l": "a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20289", "l": "acetyl-CoA + H2O = acetate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.1", "l": "\"acetyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56007", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990003", "l": "IDP phosphatase activity", "d": ["Catalysis of the reaction: IDP + H2O = IMP + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54371", "l": "acetaldehyde + H(+) + pyruvate <=> acetoin + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36023", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2201341", "l": "Endocytosis of TRAM (TICAM2) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69296", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate = 3-hydroxypent-4-ene nitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78023", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297275", "l": "CD9:Izumo Binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38788", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032315", "l": "oxo-DHAs translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875523", "l": "MET binds TNS3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56702", "l": "3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate => (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76721", "l": "3-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875591", "l": "DOCK7 activates RAC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41688", "l": "1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76662", "l": "butanal + H2O + NADP(+) <=> butanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78593", "l": "(2E)-eicosenoyl-CoA + H2O => (3S)-hydroxyeicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213207", "l": "Formation of collagen networks (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047003", "l": "dTDP-6-deoxy-L-talose 4-dehydrogenase activity", "d": ["Catalysis of the reaction: dTDP-6-deoxy-L-talose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69759", "l": "H2O + NAD(+) + nonanal = 2 H(+) + NADH + nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74101", "l": "Photons induce isomerization of 11c-retinyl to at-retinyl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381727", "l": "RAP1A exchanges GDP for GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49614", "l": "2-oxoglutarate + H(+) + NADH => (R)-2-hydroxyglutarate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13285", "l": "ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.2", "l": "\"glutamate--cysteine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53779", "l": "3-sulfanylpropanoate + O2 <=> 3-sulfinopropanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35168", "l": "minocycline(in) => minocycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39431", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836275", "l": "TFAP2A binds TFAP2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327803", "l": "Laminins bind Nidogens 1, 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952128", "l": "RUNX3 binds TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11614", "l": "2-oxoglutarate + H(+) + NADPH + NH4(+) => H2O + L-glutamate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25737", "l": "2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase] => L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31697", "l": "(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46540", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49285", "l": "8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP => CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10501", "l": "butanoyl-CoA + glyoxylate + H2O => 3-ethylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14522", "l": "(2E)-geraniol + NADP(+) => (2E)-geranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64371", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76687", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9646468", "l": "mTORC1 binds RHEB:GTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67913", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O => 1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73058", "l": "estrone 3-sulfate(out) + hydrogencarbonate(in) <=> estrone 3-sulfate(in) + hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809680", "l": "MTMR12 binds MTM1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64848", "l": "(3Z)-hex-3-en-1-ol + benzoyl-CoA = (3Z)-hex-3-en-1-yl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27884", "l": "3'-CMP + H(+) => 2',3'-cyclophospho-CMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60444", "l": "an S-substituted L-cysteinylglycine + H2O = an S-substituted L-cysteine + glycine", "d": [], "t": []}, {"i": "EC:3.4.13.23", "l": "\"cysteinylglycine-S-conjugate dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55992", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029273", "l": "PI3K binds to p-6Y-SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18532", "l": "3-methylbutanol + NAD(+) <=> 3-methylbutanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62019", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose <=> 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45096", "l": "(9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430183", "l": "NCK binds PAK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32911", "l": "sn-glycerol 3-phosphocholine(out) = sn-glycerol 3-phosphocholine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48185", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33223", "l": "2-oxobutanoate + CoA + NAD(+) = CO2 + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390674", "l": "ADRB1 bind ADR,NAd (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21772", "l": "cytidine(6666) in apoB mRNA + H(+) + H2O = NH4(+) + uridine(6666) in apoB mRNA", "d": [], "t": []}, {"i": "EC:3.5.4.36", "l": "\"mRNA(cytosine(6666)) deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63286", "l": "8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74538", "l": "2 AH2 + 2 archaetidylglycerol + 4 S-adenosyl-L-methionine <=> 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether glycerophospholipid + 4 H(+) + 4 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29863", "l": "AMP + GTP = ADP + GDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76213", "l": "GMP(out) => GMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824597", "l": "MITF-M-dependent MET gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.25", "l": "\"beta-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429497", "l": "SLP-76 stimulates PLC gamma 2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54626", "l": "2-hydroxyoctadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60954", "l": "(E)-sinapate + H(+) + S-adenosyl-L-homocysteine => (E)-5-hydroxyferulate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653724", "l": "Transcription of ATF5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68790", "l": "(Z)-gamma-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36900", "l": "guanosine(37) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75237", "l": "L-fucono-1,4-lactone => L-fucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14083", "l": "D-glyceraldehyde 3-phosphate + indole => (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72737", "l": "UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in) => UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73757", "l": "2 H(+)(in) + histamine(out) => 2 H(+)(out) + histamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0008752", "l": "FMN reductase (NAD(P)H) activity", "d": ["Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. This reaction can utilize NADH and NADPH with similar reaction rates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654603", "l": "Activated FGFR2 binds FRS3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68368", "l": "3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-xylose = 3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n+1)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14021", "l": "AH2 + ecdysone + O2 = 20-hydroxyecdysone + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.22", "l": "\"ecdysone 20-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018815", "l": "3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity", "d": ["Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36120", "l": "gibberellin A9 + S-adenosyl-L-methionine => O-methyl gibberellin A9 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15311", "l": "biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin] => (2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46430", "l": "(25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin] => 4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44966", "l": "dodecanoyl-CoA + NADP(+) => (2E)-dodecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052683", "l": "(Z)-gamma-bisabolene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55553", "l": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30304", "l": "(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71666", "l": "a menaquinone + 2 H(+)(out) + succinate <=> a menaquinol + fumarate + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16242", "l": "an NDP-alpha-D-glucose + D-fructose => a ribonucleoside 5'-diphosphate + H(+) + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848611", "l": "Phosphorylated PXN recruits the CRK complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39464", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA => (2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29334", "l": "fumarate(in) + 2 H(+)(in) <=> fumarate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67299", "l": "(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 <=> (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76387", "l": "ATP + L-glutamate + N(6)-hydroxy-L-lysine = 1-L-glutamo-2-N(6-)L-lysinohydrazine + AMP + diphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102241", "l": "soyasaponin III rhamnosyltransferase activity", "d": ["Catalysis of the reaction: UDP-L-rhamnose + soyasaponin III = H+ + UDP + soyasaponin I."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11755", "l": "acetylsalicylate + H2O <=> acetate + H(+) + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73081", "l": "S-adenosyl-L-homocysteine + scutellarein 7-methyl ether => S-adenosyl-L-methionine + scutellarein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61293", "l": "(R)-pantoate + NAD(+) => 2-dehydropantoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25784", "l": "2-dehydro-3-deoxy-L-rhamnonate = (S)-lactaldehyde + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.2.53", "l": "\"2-keto-3-deoxy-L-rhamnonate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11232", "l": "3'-phosphoadenylyl sulfate + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.6.2.2", "l": "\"phosphoadenylylsulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65985", "l": "hnu + previtamin D3 => lumisterol 3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58974", "l": "H(+) + H2O2 + vanillate => H2O + O2 + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067688", "l": "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9617595", "l": "SGTA binds mislocalized membrane protein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42365", "l": "2 a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935930", "l": "miR-18a binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446221", "l": "GMPPB converts Mannose-1-phosphate to GDP-Mannose (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58172", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = beta-pinacene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.200", "l": "\"beta-pinacene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52217", "l": "[(1''->2')-ADP-alpha-D-ribose](n) + H2O => [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65885", "l": "2-oxoglutarate + 3-hydroxy-L-kynurenine => H2O + L-glutamate + xanthurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50941", "l": "L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) => cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51609", "l": "(R)-2-hydroxyglutarate + pyruvate => (R)-lactate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004063", "l": "aryldialkylphosphatase activity", "d": ["Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050477", "l": "acyl-lysine deacylase activity", "d": ["Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78293", "l": "(R,2E)-alpha-cericerene + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26441", "l": "3-hydroxypropanoate + NADP(+) <=> 3-oxopropanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39798", "l": "7beta-hydroxycholesterol(in) + ATP + H2O <=> 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23342", "l": "D-arabinose + pyruvate => 3-deoxy-alpha-D-manno-oct-2-ulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66987", "l": "3-methylbutanoyl-CoA + H2O <=> 3-methylbutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44997", "l": "(R)-carnitine + acetoacetyl-CoA => CoA + O-3-oxobutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665871", "l": "ADRM1 binds 26S proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784189", "l": "JAKs bind LIFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46696", "l": "a pseudouridine in rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174235", "l": "Association of Emi1 with Cdc20 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170986", "l": "Ral-GDS binds to Ras-GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70669", "l": "H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein] => a fatty acyl-[ACP] + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67205", "l": "H2O + N-acetyltryptamine => acetate + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296244", "l": "SUCNR1 binds SUCCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162186", "l": "COQ3 methylates DeMQ10H2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691131", "l": "CANDI binds CUL1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682377", "l": "LC3 de-lipidation by ATG4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27981", "l": "GDP-alpha-D-mannose + H2O <=> alpha-D-mannose 1-phosphate + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296477", "l": "Defective AMN does not transport GIF:Cbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9728150", "l": "SLC5A2 binds gliflozins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38478", "l": "L-histidine + S-adenosyl-L-methionine <=> H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69579", "l": "2-oxoadipate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] <=> CO2 + N(6)-[(R)-S(8)-glutaryldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38264", "l": "(2R,3S)-beta-methylmalyl-CoA => 2-methylfumaryl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47398", "l": "an aliphatic alcohol + H(+) + octadecanoate => H2O + octadecanoate ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140348", "l": "lysophosphatidylcholine flippase activity", "d": ["Catalysis of the movement of lysophosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18583", "l": "glycolaldehyde + H2O2 + NH4(+) => ethanolamine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533970", "l": "NID1 degradation by MMP3, 7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093329", "l": "EFNBs bind SDCBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59421", "l": "H2O + methylamine + O2 => formaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69086", "l": "acrylate + 2 H(+) + NADH => acrolein + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67852", "l": "FMNH2 + O2 = FMN-N(5)-peroxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31852", "l": "(S)-2,3-epoxysqualene => parkeol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20463", "l": "an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine => an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43868", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72573", "l": "dehydroepiandrosterone 3-sulfate(out) + pentanoate(in) => dehydroepiandrosterone 3-sulfate(in) + pentanoate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102721", "l": "ubiquinol:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: O2 + 2 an ubiquinol = 2 H2O + 2 an ubiquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39248", "l": "(3R)-hydroxy-(11Z)-eicosenoyl-CoA => (2E,11Z)-eicosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103026", "l": "fructose-1-phosphatase activity", "d": ["Catalysis of the reaction: beta-D-fructofuranose 1-phosphate + H2O = beta-D-fructofuranose + hydrogenphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72243", "l": "catechol + S-adenosyl-L-methionine = guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26275", "l": "Co-precorrin-4 + S-adenosyl-L-homocysteine => Co-precorrin-3 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781899", "l": "USP13 binds SIAH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18082", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + pentalenene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691004", "l": "XPC binds RAD23 and CETN2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928591", "l": "EPH:EFN tetramers oligomerise (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873918", "l": "Transphosphorylation of JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22584", "l": "2 H(+) + heme b = Fe(2+) + protoporphyrin IX", "d": [], "t": []}, {"i": "EC:4.98.1.1", "l": "\"protoporphyrin ferrochelatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73478", "l": "D-arginine(in) + L-ornithine(out) <=> D-arginine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21323", "l": "A + D-sorbitol <=> AH2 + keto-L-sorbose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042329", "l": "structural constituent of collagen and cuticulin-based cuticle", "d": ["The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350058", "l": "Formation of CSL NCOR corepressor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72758", "l": "3 ATP <=> 3',3',3'-c-tri-AMP + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24678", "l": "5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.147", "l": "\"5,6,7,8-tetrahydromethanopterin hydro-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47932", "l": "(2S)-3-sulfolactaldehyde + H2O + NAD(+) = (2S)-3-sulfolactate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41470", "l": "H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase] => ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200555", "l": "Formation of Malonyl-CoA from Acetyl-CoA (liver) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14805", "l": "ATP + D-allose = ADP + D-allose 6-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.55", "l": "\"allose kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28548", "l": "alpha-D-fructose => alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73418", "l": "(-)-cyclopenine <=> H(+) + methyl isocyanate + viridicatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33653", "l": "(9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate => (9Z,12Z)-octadecadienoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83677", "l": "C4 deamination of cytidine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74729", "l": "5 CO2 + 6 CoA + dodecapentaneoyl-[polyketide synthase] + 5 H2O + 5 NADP(+) => acetyl-CoA + 10 H(+) + holo-[polyketide synthase] + 5 malonyl-CoA + 5 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607744", "l": "MALT1 binds BCL10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49167", "l": "a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37640", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA => 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110218", "l": "Cleavage of uracil by TDG glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.222", "l": "\"4-hydroxytryptamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56487", "l": "3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase] <=> gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32909", "l": "2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51658", "l": "keto-D-fructuronate => keto-D-tagaturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33247", "l": "O2 + putrescine = 1-pyrroline + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444647", "l": "C3a receptor binds anaphylatoxin C3a (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693347", "l": "HTR1A binds 5HT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212642", "l": "L-Glutamine transport into neurons (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848339", "l": "PNPLA5 hydrolyzes TAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446364", "l": "Migfilin interacts with VASP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34820", "l": "dihydrocurcumin + NADP(+) => curcumin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9828175", "l": "Formation of the NSL complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18824", "l": "acetyl-CoA + choline <=> acetylcholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170007", "l": "endoplasmic reticulum-lipid droplet tether activity", "d": ["The binding activity of a molecule that brings together a lipid droplet with an endoplasmic reticulum membrane, via membrane lipid binding, to establish membrane contact sites and mediate exchange and communication."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72629", "l": "2 H(+)(in) + Zn(2+)(out) => 2 H(+)(out) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796080", "l": "AcK-NFE2L2 binds the NFE2L2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55223", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624131", "l": "UNC119B binds myristoylated proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675790", "l": "MTORC1 dissociates from ULK complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033917", "l": "exo-poly-alpha-galacturonosidase activity", "d": ["Catalysis of the hydrolysis of pectic acid from the non-reducing end, releasing digalacturonate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012349", "l": "ME3 tetramer decarboxylates MAL to PYR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621615", "l": "CD209 binds ICAM3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395364", "l": "LTBP4 binds TGF-Beta-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64728", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13381", "l": "acetate + an acyl-CoA = a carboxylate + acetyl-CoA", "d": [], "t": []}, {"i": "EC:2.8.3.8", "l": "\"acetate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034536", "l": "2-hydroxy-8-methylchromene-2-carboxylate isomerase activity", "d": ["Catalysis of the reaction: 2-hydroxy-8-methylchromene-2-carboxylate = 2-hydroxy-3-methylbenzalpyruvate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653957", "l": "Rag dimer formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24339", "l": "a carboxylate + ATP + CoA <=> AMP + an acyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44854", "l": "CoA + O-(5Z)-tetradecenoyl-(R)-carnitine => (5Z)-tetradecenoyl-CoA + (R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48574", "l": "(2E,4E)-2,4-dichloromuconate + 2 H(+) => 3,5-dichlorocatechol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78443", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol = a 1,2-diacylglycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211948", "l": "CYP3A4 can N-demethylate loperamide (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63099", "l": "ilicicolin A epoxide <=> ilicicolin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14060", "l": "a 1,2-diacyl-sn-glycerol + a glycerophospholipid <=> a monoacylglycerophospholipid + a triacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112510", "l": "IL6ST is tyrosine phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49257", "l": "2-amino-2-deoxy-D-gluconate(out) + N(pros)-phospho-L-histidyl-[protein] => 2-amino-2-deoxy-D-gluconate 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203712", "l": "eNOS associates with Caveolin-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32224", "l": "(6S)-NADHX + ADP => AMP + H(+) + NADH + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013435", "l": "RHOD auto-activates (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174202", "l": "Degradation of multiubiquitinated Securin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59724", "l": "D-maltoheptaono-1,5-lactone + H2O = D-maltoheptaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63469", "l": "all-trans-octaprenol + ATP => ADP + all-trans-octaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008734", "l": "L-aspartate oxidase activity", "d": ["Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68915", "l": "ATP + H(+) + NADPH + propanoate <=> AMP + diphosphate + NADP(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36285", "l": "7-methylxanthine + formaldehyde + H2O + NADP(+) => 1,7-dimethylxanthine + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50371", "l": "2-methylbutan-2-ol + H(+) + NADPH + O2 <=> 3-hydroxy-3-methylbut-1-ene + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73160", "l": "FMN(out) + NAD(+)(in) => FMN(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1307802", "l": "MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912790", "l": "CBL binds CRK (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52126", "l": "(19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23053", "l": "ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63058", "l": "5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine => acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717841", "l": "holo-FDPS dimer binds NBPs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70295", "l": "2-oxoglutarate + 3-sulfino-L-alanine = 3-sulfinopyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53092", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64009", "l": "(4R)-hydroxysphinganine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0000497", "l": "DNA template activity", "d": ["Binding to nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21746", "l": "1-aminocyclopropane-1-carboxylate + H(+) + S-methyl-5'-thioadenosine => S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60699", "l": "(R)-lavandulyl diphosphate + H2O <=> (R)-lavandulol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018814", "l": "RHOT1 hydrolyzes GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160931", "l": "Disassembly of tight junctions (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60344", "l": "L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.361", "l": "\"[histone H4]-lysine(20) N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39910", "l": "2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose <=> dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687113", "l": "MYC mRNA translation is negatively regulated by miR-34B and C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005159", "l": "insulin-like growth factor receptor binding", "d": ["Binding to an insulin-like growth factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44726", "l": "(2E)-fatty aldehyde + H(+) + NADPH => 2,3-saturated fatty aldehyde + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417898", "l": "P2Y4 receptor can bind to UTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009072", "l": "STAT3 phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28019", "l": "enterobactin + 3 H2O => 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78392", "l": "D-mannose(out) => D-mannose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47608", "l": "3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60689", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NAD(+) => (11R)-dihydroartemisinate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65912", "l": "3-hydroxy-L-kynurenine + pyruvate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008465", "l": "hydroxypyruvate reductase (NADH) activity", "d": ["Catalysis of the reaction: (R)-glycerate + NAD+ = 3-hydroxypyruvate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56874", "l": "(S)-1-phenylethylamine + acetate => (S)-N-acetyl-1-phenylethylamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63902", "l": "(2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O => 2 3-(4-hydroxyphenyl)pyruvate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31382", "l": "H2O + pyrrole-2-carboxylate <=> 1H-pyrrole + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050166", "l": "pantoate 4-dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-pantoate + NAD+ = (R)-4-dehydropantoate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78406", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (+)-penichrysol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54276", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 = (3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65601", "l": "4,5,8-trihydroxycasbene + 2 NAD(+) => 2 H(+) + jolkinol C + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75487", "l": "dehydroepiandrosterone 3-sulfate(out) + n H(+)(out) = dehydroepiandrosterone 3-sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48357", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32472", "l": "demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase] => (7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71594", "l": "2-oxoglutarate(out) + malonate(in) <=> 2-oxoglutarate(in) + malonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50638", "l": "a 2-(omega-methylsulfanyl)alkylmaleate + H2O => a 3-(omega-methylsulfanyl)alkylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010341", "l": "gibberellin carboxyl-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a gibberellin = S-adenosyl-L-homocysteine + a gibberellin methyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50976", "l": "prostaglandin D2(out) = prostaglandin D2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13878", "l": "a 2-oxocarboxylate + L-ornithine => an L-alpha-amino acid + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982807", "l": "JAK2 phosphorylation of GHR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14792", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine <=> a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17178", "l": "(R)-carnitine + octanoyl-CoA => CoA + O-octanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863895", "l": "IKKB phosphorylates SNAP23 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.617342965326642", "identifiers": [{"i": "GO:0016832", "l": "aldehyde-lyase activity", "d": ["Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77636", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71629", "l": "phosphate(out) + succinate(in) => phosphate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9824582", "l": "MAPK1 phosphorylates SOX10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671702", "l": "AP1G2 binds HGS and CHMP2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64771", "l": "S-3-(hexan-1-ol)-L-cysteine <=> 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29000", "l": "H(+)(out) + homoserine lactone(in) => H(+)(in) + homoserine lactone(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56784", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate", "d": [], "t": []}, {"i": "EC:3.4.19.9", "l": "\"folate gamma-glutamyl hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59887", "l": "2-oxoglutarate + chloride + H(+) + L-lysine + O2 <=> 4-chloro-L-lysine + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226979", "l": "ADD1:ADD2 binds DMTN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26203", "l": "ammelide + NH4(+) => ammeline + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362386", "l": "Glycosylation of Hh (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58344", "l": "beta-D-glucosyl-(1->3)-O-lithocholate + H2O = D-glucose + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465883", "l": "VTN binds collagens I, IV and VI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47124", "l": "glycine + hexacosanoate = H2O + N-hexacosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57455", "l": "L-glutaminyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11420", "l": "NADPH + O2 + senecionine = H2O + NADP(+) + senecionine N-oxide", "d": [], "t": []}, {"i": "EC:1.14.13.101", "l": "\"senecionine N-oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76226", "l": "3',5'-cyclic AMP(in) <=> 3',5'-cyclic AMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61317", "l": "germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34451", "l": "dTDP-6-deoxy-beta-L-talose = dTDP-beta-L-rhamnose", "d": [], "t": []}, {"i": "EC:5.1.3.25", "l": "\"dTDP-L-rhamnose 4-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032781", "l": "WWTR1 (TAZ) binds TEAD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603108", "l": "Defective MAOA does not oxidatively deaminate 5HT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28333", "l": "H2O + ITP <=> H(+) + IDP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72671", "l": "eIF5B:GTP is hydrolyzed and released (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73729", "l": "Formation of SL1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64392", "l": "a dipeptide(out) + H(+)(out) = a dipeptide(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031770", "l": "growth hormone-releasing hormone receptor binding", "d": ["Binding to a growth hormone-releasing hormone receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112385", "l": "Addition of nucleotides leads to transcript elongation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44190", "l": "1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64204", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.28", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9733960", "l": "Bile salts and acids dissociate from ALB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70232", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) => (S)-2-benzoylsuccinyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23371", "l": "H(+) + phenylglyoxylate <=> benzaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798126", "l": "TP53 stimulates CASP6 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047544", "l": "2-hydroxybiphenyl 3-monooxygenase activity", "d": ["Catalysis of the reaction: biphenyl-2-ol + H+ + NADH + O2 = biphenyl-2,3-diol + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336184", "l": "GPR37L binds prosaposin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109639", "l": "Formation of the closed pre-initiation complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33291", "l": "L-pentahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-8-(methylsulfanyl)octanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22944", "l": "3beta-hydroxy-5beta-pregnane-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.277", "l": "\"3beta-hydroxy-5beta-steroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.16", "l": "\"dihydrophenazinedicarboxylate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007464", "l": "The PRC1L4 complex binds the UXT gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38928", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390930", "l": "5-HT2 receptor can bind serotonin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788623", "l": "p-Y-STATs translocate to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36028", "l": "CoA + NAD(+) + propanal => H(+) + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55492", "l": "ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24972", "l": "calcitetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14020", "l": "ATP + beta-nicotinamide D-riboside <=> ADP + beta-nicotinamide D-ribonucleotide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017057", "l": "6-phosphogluconolactonase activity", "d": ["Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37423", "l": "aclacinomycin N + O2 = aclacinomycin A + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.45", "l": "\"aclacinomycin-N oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34658", "l": "C30 botryococcene + 2 S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14138", "l": "3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine => 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014296", "l": "RAC2 GEFs activate RAC2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42726", "l": "2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine => guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378975", "l": "Follitropin is a heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43031", "l": "L-cysteate <=> 2-aminoprop-2-enoate + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45424", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839402", "l": "TGFBR3 binding to GIPC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654514", "l": "KAL1 binds FGFR1c (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51629", "l": "formate + H(+) + UTP => CO2 + dUTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25566", "l": "acetate + H(+) + N-acetylneuraminate => H2O + N-acetyl-4-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218832", "l": "CDC42:GTP binds PAK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001761", "l": "beta-alanine transmembrane transporter activity", "d": ["Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66338", "l": "L-glutamate(in) => L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110322", "l": "Formation of Pol zeta complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54482", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate => 1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047883", "l": "ethanolamine oxidase activity", "d": ["Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389463", "l": "Proteinase-activated receptors can bind thrombin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24467", "l": "2-dehydro-3-deoxy-6-phospho-D-galactonate <=> D-glyceraldehyde 3-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59036", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018582", "l": "1-hydroxy-2-naphthoate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35833", "l": "2'-dehydrokanamycin A + CO2 + NH4(+) + succinate => 2-oxoglutarate + kanamycin B + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60013", "l": "a tRNA with a 3' CC end + ATP => a tRNA with a 3' CCA end + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446391", "l": "Formation of the PINCH-ILK-parvin complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22055", "l": "A + H2O + NH4(+) <=> AH2 + H(+) + hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53414", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44333", "l": "ATP + L-alanine + L-anticapsin => ADP + bacilysin + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038062", "l": "protein tyrosine kinase collagen receptor activity", "d": ["Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48002", "l": "H2O2 + NADP(+) => 1,6-dihydro-beta-NADP + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34525", "l": "[alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP => [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16317", "l": "(S)-indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73498", "l": "an 8-hydroxyflavone + S-adenosyl-L-methionine <=> an 8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849094", "l": "ARHGAP35 binds RASA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73416", "l": "(-)-cyclopenine => H(+) + methyl isocyanate + viridicatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38032", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) => (2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37767", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451283", "l": "kainate receptor binds glutamate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655285", "l": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444523", "l": "CXCR5 binds CXCL13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57851", "l": "2-oxoglutarate + O2 + scopoletin <=> CO2 + fraxetin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685956", "l": "3a is externalized together with membrane structures (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3296233", "l": "T2Rs bind bitter-tasting compounds (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212222", "l": "PRC2 recruits DNA methyltransferases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389352", "l": "Translocation of Vav1 to CD28 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-156682", "l": "PLK1 phosphorylates NUDC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0005350", "l": "pyrimidine nucleobase transmembrane transporter activity", "d": ["Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10154", "l": "ADP + carbamoyl phosphate + H(+) + H2O => ATP + hydrogencarbonate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46776", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.45", "l": "\"sn-1 oleoyl-lipid 12-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097645", "l": "amylin binding", "d": ["Binding to amylin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110360", "l": "Recruitment of POLB to the AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69188", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate = ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14700", "l": "(2E,6E)-farnesol + NADP(+) <=> (2E,6E)-farnesal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428918", "l": "Dissociation of the TP:G13 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47645", "l": "adenosine(1914)/adenosine(1915) in 18S rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(1914)/N(6)-dimethyladenosine(1915) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879221", "l": "PSTPIP1 binds Pyrin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186765", "l": "PLC-gamma binds to the active receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008330", "l": "protein tyrosine/threonine phosphatase activity", "d": ["Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43545", "l": "ATP + L-glutamate + tyramine => ADP + gamma-L-glutamyltyramine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77588", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol => 1-dodecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4754176", "l": "JMJD6 demethylates MeR3-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61091", "l": "(S)-eriodictyol + 2-oxoglutarate + O2 <=> (2R,3R)-dihydroquercetin + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70885", "l": "H(+)(in) + L-glutamate(in) + L-glutamine(out) + Na(+)(in) => H(+)(out) + L-glutamate(out) + L-glutamine(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129353", "l": "Tropoelastin associates with microfibrils (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34381", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0043733", "l": "DNA-3-methylbase glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 3-methylbase + H2O = DNA with abasic site + 3-methylbase. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylpurine or 3-methylpyrimidine base and the deoxyribose sugar to remove the methylated base, leaving an apurinic or apyrimidinic site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416683", "l": "SEMA3E binds to PLXND1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67503", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57766", "l": "3-methyl-4-nitrocatechol + NAD(+) + nitrite => 2,6-dinitrotoluene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132187", "l": "MBL or ficolin binds an oligosaccharide pattern on the target cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56192", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14036", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol <=> 1D-myo-inositol 1-phosphate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381608", "l": "cAMP activates EPAC2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210439", "l": "glutamate uptake by astrocytes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15259", "l": "acetaldehyde + glycine => D-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48019", "l": "4-methyl-5-nitrocatechol + NADH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58658", "l": "a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine => a 5'-end 5'-phospho-ribonucleoside-RNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71276", "l": "2 Na(+)(out) + taurolithocholate 3-sulfate(out) => 2 Na(+)(in) + taurolithocholate 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74000", "l": "dimethylallyl diphosphate + quinolinone B => diphosphate + peniprequinolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380782", "l": "STAT binds to the active receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68316", "l": "1D-myo-inositol 2,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,5-triphosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71124", "l": "(E)-caffeate + ATP + H(+) + 2 malonyl-CoA => AMP + 2 CO2 + 2 CoA + diphosphate + hispidin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62873", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 => H2O + NADP(+) + semiviriditoxin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10705", "l": "ATP + L-valine + tRNA(Val) => AMP + diphosphate + L-valyl-tRNA(Val)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40634", "l": "H2O + trioctadecanoylglycerol <=> 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23763", "l": "H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043748", "l": "O-succinylbenzoate synthase activity", "d": ["Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate."], "t": []}, {"i": "RHEA:10196", "l": "(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.113", "l": "\"o-succinylbenzoate synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41574", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH => lipoxin A4 + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65189", "l": "2-oxoglutarate + berkeleyone B + O2 => berkeleydione + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874082", "l": "MET phosphorylates PTK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72631", "l": "Formation of the cap-binding eIF4F complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33573", "l": "AH2 + formaldehyde => A + methanol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18489", "l": "cyanate + H(+) + hydrogencarbonate = carbamate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026901", "l": "GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45881", "l": "3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36363", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH = (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40787", "l": "H2O + tetracosanoyl-CoA = CoA + H(+) + tetracosanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45530", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49122", "l": "H2O + NADP(+) + violaceinate => H(+) + NADPH + O2 + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61404", "l": "ATP + N-(D-ribulosyl)-cadaverine = ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23382", "l": "H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15992", "l": "(R)-mevalonate + CoA + 2 NADP(+) <=> (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45451", "l": "H2O + N-(dodecanoyl)-sphinganine <=> dodecanoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69525", "l": "D-sorbitol + O2 => D-glucose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56822", "l": "A + cyclooctat-9-ene-5,7-diol + H2O => AH2 + cyclooctat-9-en-7-ol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41752", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20727", "l": "a 4-saturated-(3S)-3-hydroxyacyl-CoA <=> a (3E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12796", "l": "1D-myo-inositol hexakisphosphate + ATP <=> 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37562", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110050", "l": "deaminated glutathione amidase activity", "d": ["Catalysis of the reaction: N-(4-oxoglutarate)-L-cysteinylglycine + H2O = 2-oxoglutarate + L-cysteinylglycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948066", "l": "K63polyUb-IRAK1 dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163539", "l": "perilipin:CGI-58 complex -> perilipin + CGI-58 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27623", "l": "geranylgeranyl diphosphate + 7 isopentenyl diphosphate => 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047885", "l": "farnesol 2-isomerase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33155", "l": "a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.106", "l": "\"2-lysophosphatidate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-901047", "l": "Binding of ERp57 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050525", "l": "cutinase activity", "d": ["Catalysis of the reaction: cutin + H2O = cutin monomers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75862", "l": "Fall Back to Closed Pre-initiation Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47954", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+) => [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165162", "l": "Phosphorylation of TSC2 by PKB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45912", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805507", "l": "APAF1 binds AVEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69945", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol => 6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2395517", "l": "NADPH transfers electrons to FDXR (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54667", "l": "(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene <=> pre-alpha-onocerin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37620", "l": "(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37496", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30158", "l": "FADH2 + 2 Fe(3+) <=> FAD + 2 Fe(2+) + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707659", "l": "Hemes:LY96 activates TLR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49432", "l": "cholate + lithocholoyl-CoA = choloyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65309", "l": "an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9620532", "l": "SIRT1,SIRT3 deacetylate FOXO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65439", "l": "a 5'-end triphospho-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + GDP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604368", "l": "Autocatalytic activation of bound proMMP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71683", "l": "2 H(+)(out) + L-aspartyl-glycine(out) = 2 H(+)(in) + L-aspartyl-glycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106177", "l": "cyclic-GMP-AMP hydrolase activity", "d": ["Catalysis of the reaction: cyclic GMP-AMP + 2 H2O = AMP + GMP."], "t": []}, {"i": "RHEA:58808", "l": "2',3'-cGAMP + 2 H2O = AMP + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62707", "l": "glycyldehydrophenylalanine + H2O <=> 2,3-didehydrophenylalanine + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66197", "l": "acetyl-CoA + tryptamine => CoA + H(+) + N-acetyltryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754964", "l": "ADA deamidates RBV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70100", "l": "H(+) + o-quinone methide + peniphenone D => penilactone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38288", "l": "(3S)-citramalate + succinyl-CoA => (3S)-citramalyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30595", "l": "4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.9", "l": "\"4-hydroxyphenylacetate 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31620", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose => dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018609", "l": "chlorobenzene dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983707", "l": "SYK autophosphorylates at the activated BCR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102946", "l": "soyasapogenol E UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + soyasapogenol E = UDP + a soyasapogenol E monoglucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102217", "l": "6-phosphoglucan, water dikinase activity", "d": ["Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-maltodextrin = n AMP + n hydrogenphosphate + a poly-6-phosphogluco-maltodextrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72095", "l": "Internal Methylation of mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418200", "l": "SRC-1 bound to ARRB2 is not activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044535", "l": "very-long-chain fatty acyl-CoA oxidase activity", "d": ["Catalysis of the reaction: very-long-chain fatty acyl-CoA (C22 - C24) + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018572", "l": "EGFR phosphorylates NOTCH3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43502", "l": "D-glucaro-1,5-lactone + H(+) + NADH => beta-D-glucuronate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17314", "l": "ATP + L-histidine + tRNA(His) => AMP + diphosphate + H(+) + L-histidyl-tRNA(His)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23869", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA => acetyl-CoA + cyclohexanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112514", "l": "JAK activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22852", "l": "L-serine + pyruvate = 3-hydroxypyruvate + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.51", "l": "\"serine--pyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12313", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 => 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64972", "l": "dUDP + H2O = dUMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59872", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24638", "l": "H(+) + NADH => H2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23928", "l": "H2O + N(8)-acetylspermidine = acetate + spermidine", "d": [], "t": []}, {"i": "EC:3.5.1.48", "l": "\"acetylspermidine deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.48", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40313", "l": "(2E)-hexenoyl-CoA + H2O2 => hexanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76312", "l": "L-aspartate(in) + L-glutamine(out) => L-aspartate(out) + L-glutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29885", "l": "ADP + H(+) + L-ornithine(in) + phosphate => ATP + H2O + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24161", "l": "D-galactose + O2 => D-galacto-hexodialdose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27481", "l": "(S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] = acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.148", "l": "\"angelicin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31404", "l": "all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) => all-trans-4,4'-diaponeurosporene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865276", "l": "PDGF-AB clevage by Furin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199910", "l": "MSK1 activates ATF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31375", "l": "H(+) + pyrrole-2-carboxylate = 1H-pyrrole + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706330", "l": "Active FLT3 binds to SOCS6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75862", "l": "Fall Back to Closed Pre-initiation Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77516", "l": "3-methoxybenzaldehyde + hydrogen cyanide => (2S)-2-hydroxy-2-(3-methoxyphenyl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60779", "l": "2-oxoglutarate + gibberellin A12 + O2 <=> CO2 + gibberellin A15 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624954", "l": "INPP5E translocates to the primary cilium (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51888", "l": "2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.404", "l": "\"tetrachlorobenzoquinone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43694", "l": "AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] => ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37810", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570493", "l": "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839368", "l": "TGFBR3(1-783) binds to TGFB1,TGFB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64990", "l": "(R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+) => CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170072", "l": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45462", "l": "a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine => H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067667", "l": "IL6 binds IL6R (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21010", "l": "diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH => diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39443", "l": "(2E,11Z,14Z,17Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781953", "l": "YOD1 binds VCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839376", "l": "TGFBR3(784-851) degradation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853801", "l": "PSPN binds RET:GFRA4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209891", "l": "Dopamine is oxidised to noradrenaline (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12159", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) <=> 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47353", "l": "a hexanoate ester + H2O => an aliphatic alcohol + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17666", "l": "L-lysyl-[protein] + octanoyl-[ACP] => H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66252", "l": "ATP + CoA + IC-asc-C7 = AMP + diphosphate + IC-asc-C7-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53721", "l": "ATP + N-acetyl-D-muramate => ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.81", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21660", "l": "benzaldehyde + H2O + NADP(+) = benzoate + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.7", "l": "\"benzaldehyde dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34956", "l": "5-(methylsulfanyl)-D-ribose(in) => 5-(methylsulfanyl)-D-ribose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047729", "l": "carnitine decarboxylase activity", "d": ["Catalysis of the reaction: carnitine + H+ = 2-methylcholine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734687", "l": "ORC6 is phosphorylated on T195 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14480", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24209", "l": "1,5-anhydro-D-mannitol + NADP(+) => 1,5-anhydro-D-fructose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167415", "l": "G-protein alpha subunit is inactivated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43155", "l": "adenosine(58) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57282", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA => a guanosine in RNA + glyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835189", "l": "NCK1 binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68965", "l": "2-hydroxyoctadecanoate + O2 => 2-oxooctadecanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.165", "l": "\"exo-1,4-beta-D-glucosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70404", "l": "(9Z)-hexadecenoyl-CoA + 3-oxosphinganine => CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210784", "l": "HNF1B-dependent synthesis of HNF6 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62228", "l": "(E)-ascladiol + A = AH2 + patulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650710", "l": "Translation of PPP1R15A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0003724", "l": "RNA helicase activity", "d": ["Unwinding of an RNA helix, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74793", "l": "(R)-salsolinol(out) => (R)-salsolinol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59435", "l": "3-hydroxypropanal + H2O + NAD(+) <=> 3-hydroxypropanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51235", "l": "2-glyceryl-prostaglandin H2 <=> 2-glyceryl-prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9824979", "l": "XPO1 binds p-S69,73 MITF-M (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28843", "l": "choline(in) + H(+)(in) = choline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392513", "l": "Rap1 signal termination by Rap1GAPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38961", "l": "a (2E)-enoyl-CoA + H2O2 => a 2,3-saturated acyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40449", "l": "(2S)-pristanoyl-CoA => (2R)-pristanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9837978", "l": "LONP1 binds mitochondrial inner membrane proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71885", "l": "H(+) + N(2)-(ADP-D-ribosyl)-GMP + nicotinamide => GMP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797100", "l": "CCNK binds CDK13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29959", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose = alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0016937", "l": "short-chain fatty acyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: a short-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4837364", "l": "Secretion of SOD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35638", "l": "an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-[2-O-(4-coumaroyl)-alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] 5-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434637", "l": "PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69044", "l": "2-nitrobutanedioate = fumarate + H(+) + nitrite", "d": [], "t": []}, {"i": "EC:4.3.99.5", "l": "\"nitrosuccinate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39944", "l": "a 1-acylglycerol + an acyl-CoA => a 1,2-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62504", "l": "3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein] = 3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.74", "l": "\"3-amino-5-hydroxybenzoate--[acyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54439", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 <=> a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32822", "l": "chromate(in) <=> chromate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41759", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 <=> 1-O-methyl-(13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807008", "l": "PTPRJ dephosphorylates MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679775", "l": "COMT binds COMT Inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51516", "l": "(R)-reticuline + S-adenosyl-L-methionine = (R)-tembetarine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36134", "l": "(indol-3-yl)acetate + S-adenosyl-L-methionine <=> methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350651", "l": "Caspase-mediated cleavage of MASK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50097", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62370", "l": "Fe(2+)(in) + 2 hydrogencarbonate(in) => Fe(2+)(out) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54574", "l": "a pseudouridine in tRNA => a uridine in tRNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186773", "l": "PDGF dimer binds two receptors simultaneously (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724685", "l": "IgE binds omalizumab (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050346", "l": "trans-L-3-hydroxyproline dehydratase activity", "d": ["Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H2O + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18933", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.107", "l": "\"3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950128", "l": "Interleukin-12 dissociates from Interleukin-12 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.11", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797961", "l": "CHDH oxidises Cho to BETALD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59033", "l": "(Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10915", "l": "(R)-pantoate + ATP + beta-alanine <=> (R)-pantothenate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35858", "l": "1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34816", "l": "2 NADP(+) + tetrahydrocurcumin => curcumin + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57326", "l": "CoA + H(+) + N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein] => acetyl-CoA + N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047153", "l": "deoxycytidylate 5-hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP + H2O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyldeoxycytidylate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55036", "l": "an N,N-dimethylornithine lipid + S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27651", "l": "GTP + uridine => GDP + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64785", "l": "S-ethyl-L-cysteine => 2-aminoprop-2-enoate + ethanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022841", "l": "potassium ion leak channel activity", "d": ["Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44453", "l": "3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine => 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53889", "l": "D-glucose 6-phosphate + TDP-alpha-D-glucose => alpha,alpha-trehalose 6-phosphate + H(+) + TDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9663511", "l": "BIL binds GSTA1, FABP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20691", "l": "(E)-caffeate + H(+) + L-quinate => chlorogenate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52628", "l": "an N-fatty-acyl-L-alpha-amino acid + H2O = a fatty acid + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25159", "l": "(R)-4'-phosphopantothenate + ATP + L-cysteine <=> AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454928", "l": "ABCG4 may mediate cholesterol efflux (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050330", "l": "theanine hydrolase activity", "d": ["Catalysis of the reaction: N(5)-ethyl-L-glutamine + H2O = L-glutamate + ethylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634850", "l": "NPAS4 binds ARNT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685531", "l": "SARS virus buds into ERGIC lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12336", "l": "carboxymethoxysuccinate = fumarate + glycolate", "d": [], "t": []}, {"i": "EC:4.2.99.12", "l": "\"carboxymethyloxysuccinate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35648", "l": "ATP + GTP => 3',3'-cGAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682011", "l": "LC3 binds ATG7 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72220", "l": "3 hydrogencarbonate(out) + Na(+)(out) => 3 hydrogencarbonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69766", "l": "a medium-chain fatty aldehyde + H2O + NAD(+) <=> a medium chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31329", "l": "bis(1L-myo-inositol) 3,1'-phosphate 1-phosphate + CMP + H(+) => 1D-myo-inositol 3-phosphate + CDP-1L-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23478", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O => 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426152", "l": "SREBP1A,2 binds the IDI1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70695", "l": "chloride(out) + glycine(out) + 3 Na(+)(out) = chloride(in) + glycine(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237069", "l": "RHAG transports CO2 from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692880", "l": "HRH3 binds Hist (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11379", "l": "(19E)-geissoschizine + NADP(+) <=> 4,21-dehydrogeissoschizine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20778", "l": "myo-inositol + stachyose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089719", "l": "RHG protein domain binding", "d": ["Binding to an RHG (reaper/hid/grimm) domain/motif (AKA iap binding motif)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855214", "l": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942224", "l": "Filaggrin binds Keratin tonofilament:Desmosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56816", "l": "a pyrimidine ribonucleoside + H2O = a pyrimidine nucleobase + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638006", "l": "ARL3 hydrolyzes GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9612509", "l": "SGK phosphorylates SRF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16002", "l": "H(+) + H2O + N(6)-methyl-AMP => IMP + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72858", "l": "ADP(out) + dADP(in) <=> ADP(in) + dADP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.323347803118935", "identifiers": [{"i": "GO:0016703", "l": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2317332", "l": "PIP3 recruits AKT to the membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22371", "l": "L-ribulose 5-phosphate <=> D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54914", "l": "11-cis-retinal + H(+) + NADPH => 11-cis-retinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034804", "l": "benzo(a)pyrene 11,12-epoxidase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-11,12-epoxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65284", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate = 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016170", "l": "interleukin-15 receptor binding", "d": ["Binding to an interleukin-15 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592398", "l": "Activation of proMMP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391168", "l": "SIRP gamma binds CD47 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30054", "l": "fluoroacetate + H2O <=> fluoride + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425861", "l": "Activation of Protein Kinase C novel isoforms (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13290", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197958", "l": "FPGS-2 transforms THF to THFPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40410", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043744", "l": "N2-acetyl-L-aminoadipate kinase activity", "d": ["Catalysis of the reaction: ATP + N-acetyl-L-2-aminoadipate = ADP + N-acetyl-L-2-aminoadipate 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560491", "l": "Expression of CEBPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55737", "l": "alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose => [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851436", "l": "CFHR dimers bind C3b (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25294", "l": "acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022911", "l": "CSPG is secreted (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41871", "l": "decanoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45862", "l": "4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73640", "l": "CTP(out) + ITP(in) => CTP(in) + ITP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33900", "l": "FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose => FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65392", "l": "4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH = (8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42035", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674531", "l": "AAMP binds EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51223", "l": "1-chloro-2,4-dinitrobenzene + glutathione <=> 2,4-dinitrophenyl-S-glutathione + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451811", "l": "YKI binds to WTS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671737", "l": "p-T774-PKN1 binds CDC25C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63216", "l": "7-cyano-7-carbaguanosine(15) in tRNA + L-lysine = 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190258", "l": "FGFR2c binds to FGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66002", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+) => (6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0035594", "l": "ganglioside binding", "d": ["Binding to a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299318", "l": "Activation of TASK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68261", "l": "D-serine(in) + Na(+)(in) => D-serine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061809", "l": "NAD+ nucleotidase, cyclic ADP-ribose generating", "d": ["Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose, in a two steps reaction: first an ADP-ribosyl cyclase reaction, followed by a cyclic ADP-ribose hydrolase reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804596", "l": "APAF1:CYCS binds APIP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39436", "l": "(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.1", "l": "\"heterotrimeric G-protein GTPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50704", "l": "1-propanol + NAD(+) = H(+) + NADH + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19080", "l": "H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] <=> 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43795", "l": "adenosine(645) in 25S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38724", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66957", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose => alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11940", "l": "2 H(+) + H2O + L-citrulline = CO2 + L-ornithine + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.20", "l": "\"citrullinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62665", "l": "(2'R)-atrovenetin + S-adenosyl-L-methionine => deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050029", "l": "L-lysine oxidase activity", "d": ["Catalysis of the reaction: L-lysine + H2O + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12875", "l": "4-methyl-2-oxopentanoate + H(+) + NADPH => (R)-2-hydroxy-4-methylpentanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1247922", "l": "GGCT transforms gGluCys to OPRO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63564", "l": "apelin-13 + H2O = apelin-12 + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56754", "l": "a Delta(14) steroid + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => a 14alpha-methyl steroid + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022860", "l": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050621", "l": "tryptophan alpha,beta-oxidase activity", "d": ["Catalysis of the reaction: L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2 + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31655", "l": "4-deoxy-Delta(4)-beta-D-GlcpA2S-(1->3)-beta-D-GalpNAc + H2O = 5-dehydro-4-deoxy-2-O-sulfo-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16994", "l": "6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] => 6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052661", "l": "S-lactaldehyde reductase activity", "d": ["Catalysis of the reaction: (S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351901", "l": "Caspase-mediated cleavage of MST3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34245", "l": "diphosphate + Mo-molybdopterin guanine dinucleotide => GTP + H(+) + Mo-molybdopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14517", "l": "(E)-feruloyl-CoA + H2O = 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802933", "l": "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1889955", "l": "B3GAT dimers transfer GlcA to tetrasaccharide linker (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74974", "l": "L-leucine(out) + L-lysine(in) + Na(+)(out) <=> L-leucine(in) + L-lysine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046526", "l": "D-xylulose reductase activity", "d": ["Catalysis of the reaction: NAD+ + xylitol = D-xylulose + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45821", "l": "mesaconate + succinyl-CoA => 2-methylfumaryl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25645", "l": "(2R,5R)-isomenthone + NADP(+) = (R)-pulegone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980048", "l": "DLL1 binds NOTCH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68767", "l": "(R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76832", "l": "H2O + hexylamine + NAD(+) => H(+) + hexanal + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39684", "l": "3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH => (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050018", "l": "L-amino-acid dehydrogenase activity", "d": ["Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8873850", "l": "STARD5 binds DCA, LCA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686335", "l": "CSF2RA:CSF2RB binds SFTPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38367", "l": "8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA = 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.260", "l": "\"tetracycline polyketide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11355", "l": "acetate + ATP <=> acetyl phosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050454", "l": "coenzyme F420 hydrogenase activity", "d": ["Catalysis of the reaction: coenzyme F420 + H(2) + H+ = reduced coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55233", "l": "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 2 Fe(III)-[cytochrome b561] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47299", "l": "dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71790", "l": "2-oxoadipate + O2 <=> (R)-2-hydroxyglutarate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1470009", "l": "Phosphorylation of STATs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432688", "l": "trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60518", "l": "D-tryptophan => L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033448", "l": "AGG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AGG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0005030", "l": "neurotrophin receptor activity", "d": ["Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71219", "l": "2 Na(+)(out) + nitrate(out) = 2 Na(+)(in) + nitrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59380", "l": "4-amino-4-deoxyprephenate + NAD(+) = 3-(4-aminophenyl)pyruvate + CO2 + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.121", "l": "\"4-amino-4-deoxyprephenate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77763", "l": "a 3'-end ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + a ribonucleoside 5'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75308", "l": "D-serine(in) + L-glutamine(out) + Na(+)(out) => D-serine(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202706", "l": "Integrin alpha4beta1 binds JAM2:JAM3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2089971", "l": "Secretion of collagens (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70718", "l": "glycine(in) <=> glycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17221", "l": "dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.46", "l": "\"dTDP-glucose 4,6-dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27277", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.71648590403835", "identifiers": [{"i": "GO:0019778", "l": "Atg12 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75924", "l": "(S)-4-aminopentanoate + H2O + NAD(+) => 4-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19145", "l": "D-glucose 6-sulfate + H2O = D-glucose + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.3", "l": "\"glycosulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40898", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482612", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50287", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56094", "l": "biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n) => (4Z,15Z)-bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48197", "l": "H(+) + heptadecanoyl-CoA + oxidized [electron-transfer flavoprotein] => reduced [electron-transfer flavoprotein] + trans-2-heptadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14811", "l": "anisole + H(+) + S-adenosyl-L-homocysteine => phenol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19246", "l": "N-phenylhydroxylamine => 2-aminophenol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16944", "l": "N-acetylindoxyl + O2 <=> H2O + N-acetylisatin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54256", "l": "2-oxoglutarate + L-histidyl-[protein] + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.79", "l": "\"protein-L-histidine (3S)-3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69299", "l": "CDT1 binds geminin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788623", "l": "p-Y-STATs translocate to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23113", "l": "6-methylsalicylate + H(+) => 3-methylphenol + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55809", "l": "a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45884", "l": "12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031758", "l": "Edg-5 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-5 sphingosine 1-phosphate receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167191", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423656", "l": "AFXBO hydrolyses non-enzymatically to AFBDHD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27848", "l": "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+) => (2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674018", "l": "BRAP binds RAS:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74733", "l": "Insulin receptor de-phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76927", "l": "3-aminopentane + H2O + NADP(+) = H(+) + NADPH + NH4(+) + pentan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9646685", "l": "Aggresome dissociates from dynein and microtubule (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2974737", "l": "NOTCH2 binds MDK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77171", "l": "biocytin + H2O = biotin + L-lysine", "d": [], "t": []}, {"i": "EC:3.5.1.12", "l": "\"biotinidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72095", "l": "Internal Methylation of mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50753", "l": "2 naphthalene-1,2,4,8-tetrol + O2 => 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16988", "l": "3-oxoadipate + NADP(+) <=> H(+) + maleylacetate + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14145", "l": "ATP + guanidinoacetate = ADP + H(+) + phosphoguanidinoacetate", "d": [], "t": []}, {"i": "EC:2.7.3.1", "l": "\"guanidinoacetate kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58689", "l": "NADH + O2 + rifamycin SV => H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62583", "l": "ATP + D-cystine(out) + H2O <=> ADP + D-cystine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35149", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out) => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46208", "l": "ATP + CoA + eicosanoate = AMP + diphosphate + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75631", "l": "H2O + plasmodiophorol B = plasmodiophorol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22361", "l": "D-glutamate => 5-oxo-D-proline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22064", "l": "5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.62", "l": "\"5alpha-hydroxysteroid dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34414", "l": "cannabigerolate + O2 <=> cannabidiolate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74041", "l": "D-alanine(in) + L-alanine(out) => D-alanine(out) + L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204485", "l": "Basigin binds CyPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33001", "l": "(+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => (+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63656", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43712", "l": "ATP + dodecanoate + H(+) = diphosphate + dodecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799441", "l": "TP53 stimulates expression of the TP53I3 (PIG3) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796368", "l": "RIPK1 binds STUB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47376", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43647", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-741411", "l": "CYLD deubiquitinates NEMO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58624", "l": "N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22382", "l": "[(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol => [(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454822", "l": "Collagen type I degradation by MMP1,2,8,13, PRSS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693347", "l": "CRYM reduces P2C to PPCA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395801", "l": "Phosphorylation of LAT by p-SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56910", "l": "acetate + H(+) + thebaine => (7S)-O-acetylsalutaridinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19793", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.5.8.3", "l": "\"sarcosine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72190", "l": "H(+)(out) + sucrose(out) <=> H(+)(in) + sucrose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112437", "l": "Formation of NELF complex  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730835", "l": "Autophosphorylation of PKC-theta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59431", "l": "3-hydroxypropanal + H2O + NADP(+) <=> 3-hydroxypropanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093342", "l": "SDC2 multimerises (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382096", "l": "Formation of NR-NCOR Corepressor Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57825", "l": "dAMP + H2O => 2-deoxy-D-ribose 5-phosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052660", "l": "R-lactaldehyde reductase activity", "d": ["Catalysis of the reaction: (R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73062", "l": "Ca(2+)(in) + Mn(2+)(out) <=> Ca(2+)(out) + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69304", "l": "(Z)-glucotropeolin + H2O = (Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68906", "l": "3-phenylpropanal + AMP + diphosphate + NADP(+) => 3-phenylpropanoate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46217", "l": "H(+) + NADPH + progesterone => 3beta-hydroxypregn-4-ene-20-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086057", "l": "voltage-gated calcium channel activity involved in bundle of His cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9846305", "l": "ST6GALNAC5,6 transfer Neu5Ac to GM1b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24674", "l": "ATP + cytidine = ADP + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204465", "l": "Basigin interacts with CD43 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12280", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.149", "l": "\"1-phosphatidylinositol-5-phosphate 4-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044014", "l": "histone H2BK5 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20040", "l": "D-sorbitol 6-phosphate + NADP(+) <=> aldehydo-D-glucose 6-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45810", "l": "(2S,3R)-dihydroxy-5-oxohexanedioate + H2O => galactarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21592", "l": "(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) = H(+) + L-2-aminopentanoate + NADH + pyruvate", "d": [], "t": []}, {"i": "EC:1.5.1.28", "l": "\"opine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9726621", "l": "PGR binds PGR antagonists (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209925", "l": "DIT and MIT combine to form triiodothyronine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211206", "l": "Translocation of DFF to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033439", "l": "ACA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60051", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + 2 H(+) + 3 NADH + 3 O2 <=> a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 4 H2O + 3 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140442", "l": "peroxide sensor activity", "d": ["Binding to hydrogen peroxide (H2O2) and eliciting a change in the protein's activity in response to the intracellular level of that small molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25909", "l": "an alditol + O2 => an aldose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61078", "l": "(-)-echitovenine + CoA => (-)-minovincinine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25305", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O <=> 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693347", "l": "CRYM reduces P2C to PPCA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46936", "l": "(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = ATP + H(+) + L-2-aminoadipate + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.95", "l": "\"L-2-aminoadipate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944352", "l": "TCF/LEF binds WNT promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67454", "l": "4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+) => a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15277", "l": "acetyl-CoA + L-lysyl-[alpha-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]", "d": [], "t": []}, {"i": "EC:2.3.1.108", "l": "\"alpha-tubulin N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69966", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030372", "l": "high molecular weight B cell growth factor receptor binding", "d": ["Binding to a high molecular weight B cell growth factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461995", "l": "pro-defensin alpha 5 is stored in Paneth cell granules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59705", "l": "D-cellohexaono-1,5-lactone + H2O => D-cellohexaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373732", "l": "Nephrin trans-homophilic interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20947", "l": "S-adenosyl-L-methionine + theobromine <=> caffeine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66592", "l": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)", "d": [], "t": []}, {"i": "EC:4.2.99.18", "l": "\"DNA-(apurinic or apyrimidinic site) lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33901", "l": "FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose => FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022456", "l": "MECP2 binds 5mC-DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8980691", "l": "RHOA GEFs activate RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070747", "l": "interleukin-35 receptor activity", "d": ["Combining with interleukin-35 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1226016", "l": "Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707516", "l": "FeHM dissociates from MetHb (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12589", "l": "a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine => a ganglioside GM2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008043", "l": "MAPK8 phosphorylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52081", "l": "12-octadecanoyloxy-octadecanoate + H2O => 12-hydroxyoctadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29166", "l": "2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out) <=> 2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75312", "l": "D-serine(in) + L-alanine(out) + Na(+)(out) => D-serine(out) + L-alanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662891", "l": "pheomelanin formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21868", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.26", "l": "\"diaminohydroxyphosphoribosylaminopyrimidine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10097", "l": "a fatty acyl-[ACP] + S-adenosyl-L-methionine => an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2167924", "l": "SMAD7:SMURF1 complex binds XPO1 (CRM1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159227", "l": "HIV Virion Budding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52555", "l": "3-dehydro-L-erythronate + ATP <=> 3-dehydro-4-O-phospho-L-erythronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810376", "l": "ING2 binds PI5P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047195", "l": "diacylglycerol-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937050", "l": "Pellino ubiquitinates hp-IRAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73286", "l": "H(+)(out) + L-isoleucine(in) <=> H(+)(in) + L-isoleucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46246", "l": "(14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51773", "l": "dimethylallyl diphosphate + phlorisobutanophenone => 4-prenylphlorisobutanophenone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54616", "l": "2-oxoglutarate + heptadecanoyl-CoA + O2 = 2-hydroxyheptadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65409", "l": "NAD(+)(in) => NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868608", "l": "Trehalose-6-phosphate is hydrolyzed to trehalose (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78154", "l": "a 3-acyl-sn-glycerol + H2O <=> a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956639", "l": "RUNX1 binds YAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875558", "l": "RAPGEF1 binds CRK,CRKL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43004", "l": "H(+) + O-carbamoyl-L-serine = 2-aminoprop-2-enoate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176175", "l": "Stalling of DNA replication fork and RPA binding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18897", "l": "3,3',5'-triiodo-L-thyronine + A + H(+) + iodide = AH2 + L-thyroxine", "d": [], "t": []}, {"i": "EC:1.21.99.3", "l": "\"thyroxine 5-deiodinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78684", "l": "a 5'-end triphospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27523", "l": "2,5-dihydroxypyridine + O2 => H(+) + N-formylmaleamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58679", "l": "NADPH + O2 + rifamycin SV <=> H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444572", "l": "Zinc is an agonist of GPR39 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050520", "l": "phosphatidylcholine synthase activity", "d": ["Catalysis of the reaction: CDP-diacylglycerol + choline = 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23090", "l": "1-O-alkylglycerone 3-phosphate + ADP + H(+) => ATP + O-alkylglycerone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390302", "l": "tetracosenoyl-CoA + 8 O2 + 8 H2O + 8 NAD+ + 8 CoASH => octanoyl-CoA + 8 H2O2 + 8 NADH + 8 H+ + 8 acetyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655240", "l": "Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66263", "l": "CoA + IC-asc-C7-AMP <=> AMP + H(+) + IC-asc-C7-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14126", "l": "2 raffinose => 1(F)-alpha-D-galactosylraffinose + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58016", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5082387", "l": "Phosphorylation of HSF1 at Ser230 induces transactivation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443439", "l": "c-Src binds Raf1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65532", "l": "2-methylbutan-1-ol + hexanoyl-CoA = 2-methylbutyl hexanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30584", "l": "2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide => 2-demethylmenaquinone-8 + H2O + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29641", "l": "alpha-D-glucose + D-maltopentaose => D-maltohexaose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9842648", "l": "Autophosphorylation of LTK dimer:ALKAL1,2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65944", "l": "AH2 + CTP + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864577", "l": "TFAP2C translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78314", "l": "dAMP + dATP <=> 2 dADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210430", "l": "Release of L-Glutamate at the synapse (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046423", "l": "allene-oxide cyclase activity", "d": ["Catalysis of the reaction: (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75421", "l": "(S)-acetoin + H(+) + NADH => (R,S)-butane-2,3-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114683", "l": "Phosphorylation of Platelet Sec-1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005528", "l": "FK506 binding", "d": ["Binding to a 23-membered macrolide lactone FK506."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667914", "l": "ALK binds ligand midkine (MDK) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57285", "l": "a guanosine in RNA + methylglyoxal => an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23055", "l": "ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit] <=> ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "57.257992915928938", "identifiers": [{"i": "GO:0097159", "l": "organic cyclic compound binding", "d": ["Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001092", "l": "TFIIA-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32717", "l": "2-oxobutanoate + CO2 + NADH => (2R,3S)-3-methylmalate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69581", "l": "dGMP + inosine => 2'-deoxyguanosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69729", "l": "diphosphate + phenylacetyl-AMP => 2-phenylacetate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033403", "l": "UUA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UUA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033836", "l": "flavonol 7-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77303", "l": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51325", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 => (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099626", "l": "voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels", "d": ["Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785126", "l": "FA core complex assembles at DNA interstrand crosslinks (ICLs) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473184", "l": "Follistatin (FST) binds Activin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43853", "l": "H(+) + malonyl-CoA + triacontanoyl-CoA => 3-oxo-dotriacontanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404142", "l": "atROL binds RBP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49099", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + 3 S-adenosyl-L-methionine <=> 3,8-divinyl protochlorophyllide a + 3 5'-deoxyadenosine + 4 H(+) + 3 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2214351", "l": "PLK1 phosphorylates GORASP1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32493", "l": "10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67903", "l": "glutarate + succinyl-CoA <=> glutaryl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018575", "l": "chlorocatechol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013145", "l": "RAC1 binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39803", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O + NAD(+) = (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50248", "l": "ATP + D-ribose 5-phosphate + H(+) = ADP-D-ribose + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.96", "l": "\"ADP-D-ribose pyrophosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46684", "l": "3-oxochol-4-en-24-oyl-CoA + A = (22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0070037", "l": "rRNA (pseudouridine) methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule."], "t": []}, {"i": "REACT:R-HSA-6790906", "l": "EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186773", "l": "PDGF dimer binds two receptors simultaneously (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15801", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49075", "l": "dibenzothiophene + 2 FMNH2 + 2 O2 <=> dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.95", "l": "\"dextran 1,6-alpha-isomaltotriosidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10161", "l": "L-iditol + NAD(+) => H(+) + keto-L-sorbose + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249392", "l": "NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654569", "l": "Activated FGFR1 binds FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706319", "l": "Active FLT3 binds to SLA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102292", "l": "30-hydroxy-beta-amyrin 11-hydroxylase activity", "d": ["Catalysis of the reaction: 30-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11alpha,30-dihydroxy-beta-amyrin + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434053", "l": "TRAF6 binds to p-IRAK2 complexed with activated TLR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671970", "l": "Activated CIT binds KIF14 and PRC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351849", "l": "Caspase-mediated cleavage of Etk (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67672", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76370", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(out) <=> n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429955", "l": "CCR4-NOT complex deadenylates mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480301", "l": "Expression of EPAS1 (HIF2A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74889", "l": "2',3'-cGAMP(out) + ADP + H(+) + phosphate => 2',3'-cGAMP(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.4", "l": "\"ribonuclease H\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.3", "l": "\"homoserine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001063", "l": "glucomannan binding", "d": ["Binding to glucomannan."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9851407", "l": "FAM83B, (FAM83A, FAM83D) bind EGFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797100", "l": "CCNK binds CDK13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876472", "l": "NPC2 binds CHOL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68122", "l": "a triacylglycerol + CoA => a 1,2-diacylglycerol + a fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71888", "l": "GTP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30457", "l": "(-)-geosmin => (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43218", "l": "(24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine => (24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27397", "l": "4'-demethylrebeccamycin + H2O = beta-D-glucose + dichloroarcyriaflavin A", "d": [], "t": []}, {"i": "EC:4.3.3.5", "l": "\"4'-demethylrebeccamycin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30336", "l": "CTP + H(+) + H2O => NH4(+) + UTP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31743", "l": "a 4'-hydroxyflavanone + S-adenosyl-L-methionine = a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.231", "l": "\"flavonoid 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22917", "l": "4'-hydroxyacetophenone + H(+) + NADPH + O2 => 4-acetoxyphenol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53445", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24000", "l": "a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18904", "l": "H(+) + H2O + N-benzyloxycarbonyl-L-leucine <=> benzyl alcohol + CO2 + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693598", "l": "ATM phosphorylates NBN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444661", "l": "HCAR2 binds HCAR2 ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61762", "l": "rebaudioside A + UDP => rebaudioside B + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17709", "l": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15315", "l": "acetaldehyde + NH4(+) => ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700156", "l": "Active ALK dimer binds IRS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49084", "l": "(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] = (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.72", "l": "\"(-)-pluviatolide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295622", "l": "SPRY2 binds CBL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35720", "l": "(3S)-versiconol acetate + H2O => (S)-versiconol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54687", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (-)-kolavenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51832", "l": "ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450490", "l": "Protein Kinase B/Akt phosphorylates BRF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850794", "l": "SPINK6 binds KLK5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399995", "l": "Muscarinic Acetylcholine Receptor M3 activates Gq (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684351", "l": "pp1a cleaves itself (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12500", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193072", "l": "CYP17A1 17-hydroxylates P4 to 17aHPROG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69862", "l": "a uridine in 12S rRNA + S-adenosyl-L-methionine <=> a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130706", "l": "MHC class II antigen processing (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47440", "l": "(3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+) = 3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73806", "l": "AIR + CO2 => CAIR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070636", "l": "nicotinic acid riboside hydrolase activity", "d": ["Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49101", "l": "H2O + Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-methionine => 5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42501", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) => 6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23487", "l": "A + D-cellobiose <=> AH2 + D-cellobiono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016497", "l": "substance K receptor activity", "d": ["Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28702", "l": "Mn(2+)(in) <=> Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24271", "l": "2,6-dioxo-6-phenylhexanoate + NADP(+) <=> 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933528", "l": "Interaction of MEKK1 with TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210943", "l": "pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17136", "l": "ATP + L-seryl-[tyrosine-3-monooxygenase] <=> ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47334", "l": "16alpha,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9825759", "l": "MAPK-dependent phosphorylation of KARS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140806", "l": "SERPINC1 binds SERPINC1 activators (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70417", "l": "(3,5-dihydroxyphenyl)acetate + CoA + H(+) => (3,5-dihydroxyphenyl)acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78851", "l": "a long-chain 2,3-saturated fatty acyl-CoA + O2 = a long-chain (2E)-enoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5662620", "l": "MT3 binds cadmium (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42435", "l": "3-hydroxy-cis,cis-muconate <=> maleylacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714483", "l": "RAC2 translocates to the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38015", "l": "delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70103", "l": "H(+) + o-quinone methide + penilactone D = penilactone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15466", "l": "ATP + sphinganine => ADP + H(+) + sphinganine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76716", "l": "(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione => (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69560", "l": "D-mannose(out) + H(+)(out) = D-mannose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20535", "l": "phosphate + pyridoxal => H2O + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56570", "l": "a globoside IV3GalNAc-Gb4Cer + H(+) + UDP => a globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75790", "l": "GTP(in) <=> GTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74603", "l": "CMP(out) + UDP-alpha-D-galactose(in) = CMP(in) + UDP-alpha-D-galactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132277", "l": "Complement factor H binds to surface-bound C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654425", "l": "Activated FGFR4 binds SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70818", "l": "H(+)(in) + L-histidine(in) + L-ornithine(out) <=> H(+)(out) + L-histidine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9681375", "l": "KIT binds ripretinib (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13042", "l": "L-dopachrome => 5,6-dihydroxyindole-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140897", "l": "mechanoreceptor activity", "d": ["Combining with a mechanical force and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24310", "l": "7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696275", "l": "RND2 binds GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696357", "l": "LAIR2 binds collagen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37537", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034722", "l": "gamma-glutamyl-peptidase activity", "d": ["Catalysis of the cleavage of a gamma-linked glutamate bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43055", "l": "3-(methylsulfanyl)propanoate + ATP + CoA <=> 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865605", "l": "BRWD1 binds SMARCA4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202174", "l": "Activation of ZAP-70 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11148", "l": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O", "d": [], "t": []}, {"i": "EC:1.16.3.1", "l": "\"ferroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654655", "l": "Activated FGFR4 phosphorylates PPTN11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299297", "l": "Activation of THIK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56112", "l": "2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034639", "l": "L-amino acid efflux transmembrane transporter activity", "d": ["Enables the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12130", "l": "2-oxoglutarate + 2 H(+) + L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin] => 2 L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728664", "l": "GLP1R binds GLP1R agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59513", "l": "acetylsalicylate + L-seryl-[protein] => O-acetyl-L-seryl-[protein] + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1606839", "l": "ARSC hydrolyzes steroid sulfates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033976", "l": "2-haloacid dehalogenase (configuration-inverting) activity", "d": ["Catalysis of the reactions: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70265", "l": "1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607736", "l": "MALT1 oligomerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.5", "l": "\"aldehyde oxygenase (deformylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.9", "l": "\"Xaa-Pro aminopeptidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16632", "l": "(S)-malyl-CoA <=> acetyl-CoA + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853762", "l": "RET dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.6", "l": "\"CC-preferring endodeoxyribonuclease\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.25", "l": "\"lipopolysaccharide heptosyltransferase III\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10681", "l": "L-proline => D-proline", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44710", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680389", "l": "CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12435", "l": "L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76577", "l": "5-dehydro-4-deoxy-D-glucuronate => 4-deoxy-L-threo-hex-4-enopyranuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362485", "l": "GHBP binds GH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41838", "l": "3-oxooctanoyl-[ACP] + CO2 + holo-[ACP] => H(+) + hexanoyl-[ACP] + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044669", "l": "sodium:galactoside symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ galactoside(out) = sodium(in) + galactoside(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.11", "l": "\"2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.33584335509623", "identifiers": [{"i": "GO:0004713", "l": "protein tyrosine kinase activity", "d": ["Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461971", "l": "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9678925", "l": "NR3C1 binds NR3C1 agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164617", "l": "Elongation of Extended Telomeric Chromosome End (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16185", "l": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70015", "l": "O2 + reduced [NADPH--hemoprotein reductase] + teasterone = 7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20982", "l": "2 biliverdin IXalpha + 2 H2O => 2 (4Z,15Z)-bilirubin IXalpha + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65031", "l": "(+)-pinoresinol + H2O + 2 oxidized [azurin] <=> (+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77473", "l": "(2S)-2-hydroxy-2-methylpentanenitrile => hydrogen cyanide + pentan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-688137", "l": "RIP2 is K63 polyubiquitinated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22488", "l": "S-(hydroxymethyl)glutathione = formaldehyde + glutathione", "d": [], "t": []}, {"i": "EC:4.4.1.22", "l": "\"S-(hydroxymethyl)glutathione synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57479", "l": "dodecanoate + H2O2 <=> 2-hydroxydodecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72132", "l": "agmatine(out) => agmatine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0005041", "l": "low-density lipoprotein particle receptor activity", "d": ["Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49033", "l": "(-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] => 4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-606326", "l": "HJURP:CENPA complex localizes to the centromere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51427", "l": "a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O <=> ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13943", "l": "ADP + D-glyceraldehyde 3-phosphate + H(+) => ATP + D-glyceraldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800868", "l": "NDUF subunits bind to form the IP subcomplex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167429", "l": "The receptor:G-protein complex  binds GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111879", "l": "PIP2 hydrolysis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11409", "l": "H(+) + H2O + riboflavin => lumichrome + ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53282", "l": "D-erythrulose => D-threose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18674", "l": "ATP + L-seryl-[receptor-protein] => ADP + H(+) + O-phospho-L-seryl-[receptor-protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14994", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.30", "l": "\"receptor protein serine/threonine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16053", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine = H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.187", "l": "\"N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237160", "l": "MTA is cleaved and phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016897", "l": "RNA exonuclease activity, producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters."], "t": []}, {"i": "EC:3.1.14.-", "l": "\"Exoribonucleases producing 3'-phosphomonoesters\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9641111", "l": "Parkin transfers Ub to misfolded proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49941", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 => (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084912", "l": "Arresten binds integrin alpha1beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684140", "l": "ATM phosphorylates RBBP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362416", "l": "Frataxin binds iron (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120147", "l": "formylglycine-generating oxidase activity", "d": ["Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2172126", "l": "DAP12 interacts with NKG2C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30949", "l": "10-epi-gamma-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011971", "l": "Estrogen-responsive MYB gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68479", "l": "a (2R)-2-hydroperoxy fatty acid + H(+) <=> a fatty aldehyde + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20981", "l": "2 (4Z,15Z)-bilirubin IXalpha + O2 => 2 biliverdin IXalpha + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32461", "l": "H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + uroporphyrinogen III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72238", "l": "2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) <=> 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52819", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49720", "l": "2 H(+) + NADH + 2 O2 + protoviolaceinate = CO2 + 2 H2O + NAD(+) + violacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24308", "l": "25-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41774", "l": "a ganglioside GQ1b (d18:1(4E)) + CMP + H(+) => a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102872", "l": "1-16:0-2-18:2-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + O2 + a reduced electron acceptor = 1-16:0-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388900", "l": "Neurotensin receptors can bind neurotensins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015173", "l": "aromatic amino acid transmembrane transporter activity", "d": ["Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76049", "l": "(S)-cis-N-methyltetrahydropalmatine + S-adenosyl-L-homocysteine => (S)-tetrahydropalmatine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26243", "l": "diphosphate + elisabethatriene => geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0008192", "l": "RNA guanylyltransferase activity", "d": ["Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23566", "l": "2 berberine + 2 H2O => 2 columbamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793451", "l": "MLKL binds ITCH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22274", "l": "(20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34725", "l": "15-methylhexadecasphing-4-enine + phosphate => 15-methylhexadecasphing-4-enine 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654409", "l": "Activated FGFR3 binds FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14509", "l": "2-oxoglutarate + mugineate + O2 = 3-epihydroxymugineate + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166286", "l": "Multiple IRAK1 autophosphorylation steps (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2272753", "l": "Interaction of DAP12 and KIR2DS4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168301", "l": "Elongation, Polyadenylation and Termination (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64502", "l": "3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine => acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63233", "l": "(2E)-octenoyl-CoA + H(+) + NADH => NAD(+) + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033845", "l": "hydroxymethylfurfural reductase (NADPH) activity", "d": ["Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698933", "l": "HCMV B Nucleocapsid Translocation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14737", "l": "CTP = 3',5'-cyclic CMP + diphosphate", "d": [], "t": []}, {"i": "EC:4.6.1.6", "l": "\"cytidylate cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60905", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73740", "l": "dopamine(in) + 2 H(+)(out) => dopamine(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52978", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin] => a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507869", "l": "Aquaporins passively transport glycerol into cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989755", "l": "Expression of CYP4A11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047343", "l": "glucose-1-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + CTP = CDP-D-glucose + diphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30389", "l": "alpha-D-glucose 1-phosphate + GDP + H(+) => GDP-alpha-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40316", "l": "glutaryl-CoA + O2 => (2E)-glutaconyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68549", "l": "O2 + psoralen + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32684", "l": "5-hydroxymethylfurfural + 2 H2O + 3 O2 => 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25318", "l": "2-oxoglutarate + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate <=> L-2-acetamido-6-oxoheptanedioate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186819", "l": "SH2 domain of Src binds to the active receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004343", "l": "glucosamine 6-phosphate N-acetyltransferase activity", "d": ["Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47201", "l": "(24S)-7alpha-dihydroxycholesterol + NAD(+) => (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2559439", "l": "CD14:LPS binds CR3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59864", "l": "(indol-3-yl)butanoate + ATP + L-glutamine = (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32381", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADH => (1R,2R,4S)-limonene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18368", "l": "(R)-malate + NAD(+) <=> CO2 + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69818", "l": "cathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34187", "l": "(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67354", "l": "6-O-malonyl-rhaponticin + CoA => malonyl-CoA + rhaponticin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944229", "l": "Association of procollagen type IX (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73987", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + discoidol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73824", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate => an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11690", "l": "AMP + diphosphate + L-leucyl-tRNA(Leu) => ATP + L-leucine + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669240", "l": "FLNA binds PAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37006", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799335", "l": "Synthesis of nascent polypeptide containing signal sequence (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37204", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-396996", "l": "Thrombin-activated PARs binds G-protein Gq (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62167", "l": "beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O <=> D-glucosamine + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043712", "l": "2-hydroxyisocaproate CoA-transferase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyisocaproate + isocaproyl-CoA = (R)-2-hydroxyisocaproyl-CoA + isocaproate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53112", "l": "3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) = 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12849", "l": "H2O + O-phospho-L-seryl-[myosin light chain] = L-seryl-[myosin light chain] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66172", "l": "H(+)(out) + L-cystine(out) = H(+)(in) + L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796044", "l": "NFE2L2 dependent EGF expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59883", "l": "4-hydroxyphenylacetate + FMNH2 + O2 <=> 3,4-dihydroxyphenylacetate + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63793", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64795", "l": "L-lysine + NADP(+) <=> 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13997", "l": "3-methyl-2-oxobutanoate + CoA + NAD(+) = 2-methylpropanoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9687625", "l": "ATP binds MLKL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22082", "l": "H2O + NAD(+) + quinoline-2,8-diol => H(+) + NADH + O2 + quinolin-2-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32181", "l": "dipicolinate + H(+) + NADH => (S)-2,3-dihydrodipicolinate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77068", "l": "Activation of GT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30570", "l": "5,6,7,8-tetrahydromethanopterin + ATP + L-glutamate <=> 5,6,7,8-tetrahydrosarcinapterin + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10237", "l": "trans-2-coumarate + UDP-alpha-D-glucose => H(+) + trans-beta-D-glucosyl-2-hydroxycinnamate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198669", "l": "p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13781", "l": "an L-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.3.2", "l": "\"L-amino-acid oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35722", "l": "(3S)-versiconol acetate + H2O <=> (S)-versiconol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770129", "l": "Formation of the Spliceosomal A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341048", "l": "SUMOylation of RXRA with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9902096", "l": "COX18 inserts nascent MT-CO2 in COX20:TMEM77 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190520", "l": "Association of Golgi  transport vesicles with microtubules (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928607", "l": "p-EPHs bind VAV2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102942", "l": "3,5-dimethoxyphenol O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,5-dimethoxyphenol + S-adenosyl-L-methionine = H+ + 1,3,5-trimethoxybenzene + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9704151", "l": "CHRM1,3,5 bind CHRM1,3,5 antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49686", "l": "benzene-1,2,4-triol + H2O + NAD(+) => H(+) + NADH + O2 + resorcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018794", "l": "RHOV binds effectors at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25662", "l": "(2E)-geranyl diphosphate = alpha-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390598", "l": "Myosin Binds ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141341", "l": "SMOX-3 oxidises SPN to SPM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57456", "l": "(E)-sinapate + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-688137", "l": "RIP2 is K63 polyubiquitinated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874083", "l": "p-Y397-PTK2 binds SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687107", "l": "MAPK4,6 translocate to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62171", "l": "H2O + N,N'-diacetylchitobiose <=> acetate + beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102601", "l": "cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity", "d": ["Catalysis of the reaction: beta-amyrin + O2 + H+ + NADPH = 16beta-hydroxy-beta-amyrin + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62641", "l": "[mycoredoxin]-L-dithiol + a hydroperoxide => [mycoredoxin]-L-disulfide + an alcohol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381087", "l": "Dimerization of PERK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038025", "l": "reelin receptor activity", "d": ["Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14045", "l": "1-carboxyvinyl carboxyphosphonate + H(+) = 3-(hydrohydroxyphosphoryl)pyruvate + CO2", "d": [], "t": []}, {"i": "EC:2.7.8.23", "l": "\"carboxyvinyl-carboxyphosphonate phosphorylmutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49897", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate => 5,10-dihydrophenazine-1,6-dicarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043024", "l": "ribosomal small subunit binding", "d": ["Binding to a small ribosomal subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76873", "l": "acetophenone + H(+) + NADH + NH4(+) => (S)-1-phenylethylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45006", "l": "CoA + O-2,6-dimethylheptanoyl-(R)-carnitine => (R)-carnitine + 2,6-dimethylheptanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858238", "l": "AXL3 binds MITF promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980042", "l": "NOTCH1 binds JAG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392530", "l": "p-S400-Cot phosphorylates NIK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37807", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37355", "l": "H2O + uridine 2'-phosphate = phosphate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38001", "l": "H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine => 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205321", "l": "Interaction of KIT and sSCF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944220", "l": "Association of procollagen type XXIII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174088", "l": "Association of cell cycle proteins with the APC/C:Cdh1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "62.748495915503312", "identifiers": [{"i": "GO:0015291", "l": "secondary active transmembrane transporter activity", "d": ["Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters."], "t": []}, {"i": "TCDB:2.A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32174", "l": "H(+) + NADPH + O2 + phenylacetyl-CoA <=> 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167429", "l": "The receptor:G-protein complex  binds GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17431", "l": "4-oxocyclohexanecarboxylate + H(+) + NADH => NAD(+) + trans-4-hydroxycyclohexanecarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43007", "l": "H(+) + O-carbamoyl-L-serine <=> 2-aminoprop-2-enoate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264622", "l": "Cho is acetylated to AcCho by CHAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72697", "l": "Start codon recognition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391168", "l": "SIRP gamma binds CD47 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20127", "l": "NADPH + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42857", "l": "1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O => 1,2-dioctanoyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57741", "l": "a 2,3-saturated meromycolyl-[ACP] + NAD(+) => a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102844", "l": "1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity (SN2-16:2 forming)", "d": ["Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202721", "l": "JAM2 binds JAM3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56003", "l": "H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] <=> beta-D-glucose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018804", "l": "RAC3 GEFs activate RAC3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32331", "l": "(1S,2S,4R)-endo-fenchol + NAD(+) = (1S,4R)-fenchone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445064", "l": "Activation of Rac1 by VAV2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28127", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose => alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64551", "l": "N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] <=> (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022396", "l": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-43) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050553", "l": "taxadiene synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33518", "l": "2 5,6-dihydroxyindole + O2 <=> 2 H2O + 2 indole-5,6-quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26493", "l": "a secondary nitroalkane + H2O + O2 <=> a ketone + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76253", "l": "glutarate(out) => glutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18476", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48941", "l": "an L-aminoacyl-L-amino acid + H2O => 2 an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852013", "l": "BTNL8 binds resting T cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15890", "l": "H2O + L-glutamine => L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.3", "l": "\"type I site-specific deoxyribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016640", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule."], "t": []}, {"i": "EC:1.4.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46552", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.39", "l": "\"acyl-lipid Delta(12)-acetylenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-994148", "l": "LRRC16A binds F-actin capping protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.34", "l": "\"plasma kallikrein\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420724", "l": "CASR binds Ca2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166015", "l": "Association of LBP with LPS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372448", "l": "SLC25A12,13 exchange L-Glu and L-Asp (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6790038", "l": "Expression of HSP90B1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67122", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190788", "l": "Formation of junctional channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948027", "l": "RNASEs bind bacterial phospholipids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74738", "l": "S-adenosyl-L-methionine + syringetin <=> 7,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36407", "l": "ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate", "d": [], "t": []}, {"i": "EC:2.7.7.87", "l": "\"L-threonylcarbamoyladenylate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0016662", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome."], "t": []}, {"i": "EC:1.7.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20301", "l": "ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)", "d": [], "t": []}, {"i": "EC:6.1.1.19", "l": "\"arginine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985594", "l": "MYO9B inactivates RHOA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198669", "l": "p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928645", "l": "EPHB:NMDAR binds TIAM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69761", "l": "2 H(+) + NADH + nonanoate => H2O + NAD(+) + nonanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18538", "l": "H2O + NAD(+) + salicylaldehyde => 2 H(+) + NADH + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34875", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + 2 H2O + NADP(+) = 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54675", "l": "(+)-kolavenyl diphosphate + H2O <=> (+)-kolavelool + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373730", "l": "Neurofascin and NrCAM heterodimerization (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23275", "l": "an N(6)-alkylaminopurine + UDP-alpha-D-glucose <=> an N(6)-alkylamino-7-beta-D-glucosylpurine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41120", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65567", "l": "(9Z)-octadecenoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-octadecenoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36038", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NADP(+) <=> 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45248", "l": "butanoate(out) = butanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61551", "l": "ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47888", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine = GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32571", "l": "(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.118", "l": "\"2-methylisoborneol synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11756", "l": "ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}, {"i": "EC:6.3.4.15", "l": "\"biotin--[biotin carboxyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74674", "l": "UDP-beta-L-arabinopyranose(in) + UMP(out) <=> UDP-beta-L-arabinopyranose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17403", "l": "4-carboxy-2-hydroxy-cis,cis-muconate + H2O => 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36928", "l": "(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38620", "l": "nicotinate beta-D-ribonucleotide + phenol => H(+) + nicotinate + phenyl 5-phospho-alpha-D-ribofuranoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60895", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O <=> a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59162", "l": "AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase] => ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73759", "l": "guanosine(2553) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2553) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9856871", "l": "MDH1 reduces OA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16690", "l": "D-glucose 6-phosphate + H2O => D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32806", "l": "ATP + H2O + urea(out) <=> ADP + H(+) + phosphate + urea(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160080", "l": "ABC-type indole transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + indole(in) = ADP + phosphate + indole(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004484", "l": "mRNA guanylyltransferase activity", "d": ["Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16895", "l": "N-methylpyridinium + S-adenosyl-L-homocysteine => pyridine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67939", "l": "a 2-hydroxy carboxylate + O2 <=> a 2-oxocarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51011", "l": "2 Fe(III)-[cytochrome cL] + methanol <=> 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735268", "l": "GATA4 and NKX2-5 bind the HAND1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31379", "l": "H2O + pyrrole-2-carboxylate = 1H-pyrrole + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55892", "l": "a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 = a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678854", "l": "S1PR1 binds S1PR1 agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50978", "l": "prostaglandin D2(in) => prostaglandin D2(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45243", "l": "a (3E,5Z)-dienoyl-CoA <=> a (2E,4E)-(5,6-saturated)-dienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57781", "l": "2-chloro-4-nitrotoluene + NADH + O2 => 3-chloro-4-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64947", "l": "dCTP + 2 H2O <=> dCMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672978", "l": "RAF phosphorylates MAP2K dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390598", "l": "Myosin Binds ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44822", "l": "2-demethylmenaquinol-13 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984671", "l": "Chromokinesins form dimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54991", "l": "4 e(-) + 4 H(+)(in) + O2(in) <=> 2 H2O(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.51", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17125", "l": "H2O + N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine = 2-oxoglutarate + N-(2-aminobutanoyl)glycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46352", "l": "(2E)-decenoyl-CoA + H2O = 3-hydroxydecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20962", "l": "1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32462", "l": "2 S-adenosyl-L-methionine + uroporphyrinogen III <=> H(+) + precorrin-2 + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55738", "l": "[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP => alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162188", "l": "COQ5 methylates MDMQ10H2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58963", "l": "benzaldehyde + H2O + O2 <=> benzoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855172", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43387", "l": "ATP + L-arginyl-[protein] <=> ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77042", "l": "4-hydroxyhexan-3-amine + H2O + NAD(+) <=> 4-hydroxyhexan-3-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.71648590403835", "identifiers": [{"i": "GO:0016289", "l": "acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: an acyl-CoA + H2O = a carboxylate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42154", "l": "a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.4", "l": "\"poly(A)-specific ribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031882", "l": "type 5 somatostatin receptor binding", "d": ["Binding to a type 5 somatostatin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654651", "l": "Activated FGFR4 binds FRS3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33111", "l": "(2E,6E)-farnesyl diphosphate = beta-copaene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.127", "l": "\"beta-copaene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64032", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047743", "l": "chlordecone reductase activity", "d": ["Catalysis of the reaction: chlordecone alcohol + NADP+ = chlordecone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16215", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13610", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38137", "l": "1-(9Z,12Z,15Z-octadecatrienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683714", "l": "Unphosphorylated nucleoprotein translocates to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76723", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 5-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19786", "l": "2-oxoglutarate + dihydroclavaminate + O2 => clavaminate + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63766", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44852", "l": "(5Z)-tetradecenoyl-CoA + (R)-carnitine = CoA + O-(5Z)-tetradecenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74190", "l": "S-adenosyl-L-methionine + taxifolin <=> H(+) + S-adenosyl-L-homocysteine + taxifolin 3'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811427", "l": "COPI vesicle uncoating at the ER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31044", "l": "(S)-2-methyl-3-oxopropanoate + H2O + NAD(+) => 2 H(+) + methylmalonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106226", "l": "peptide 2-hydroxyisobutyryltransferase activity", "d": ["Catalysis of the reaction: 2-hydroxyisobutyryl-CoA + lysine in peptide = CoA + N-2-hydroxyisobutyryl-lysine-peptide."], "t": []}, {"i": "RHEA:24180", "l": "2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31870", "l": "(S)-2,3-epoxysqualene <=> baccharis oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952371", "l": "MDM2 binds RUNX3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418662", "l": "Src activation following P2Y purinoceptor activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39226", "l": "(3R)-hydroxyoctacosanoyl-CoA <=> (2E)-octacosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9713837", "l": "Psoralens in combination with UV generate DNA interstrand crosslinks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237119", "l": "Acireductone is oxidized to MOB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0001016", "l": "RNA polymerase III transcription regulatory region sequence-specific DNA binding", "d": ["Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070866", "l": "sterol-dependent protein binding", "d": ["Binding to a protein or protein complex in the presence of sterols."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977301", "l": "Histidine is decarboxylated to histamine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46000", "l": "adenosine + H(+) + tuberculosinyl diphosphate = 1-tuberculosinyladenosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75348", "l": "thiocyanate(in) => thiocyanate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805276", "l": "CDK5 phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56830", "l": "2,3,5,6-tetrachlorohydroquinone + 2 glutathione => 2,3,6-trichlorohydroquinone + chloride + glutathione disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691004", "l": "XPC binds RAD23 and CETN2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73841", "l": "AMP + 2 H(+) + phenyl phosphate + phosphate => ATP + H2O + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811479", "l": "ING2 recruits EP300 to TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30232", "l": "H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine => (2E,6E)-farnesal + H2O2 + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2025890", "l": "Calcineurin binds NFATC1,2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67988", "l": "N-acetyl-L-glutamine = N-acetyl-D-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59612", "l": "beta-alanyl-L-ornithine + H2O = beta-alanine + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62092", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66173", "l": "H(+)(out) + L-cystine(out) => H(+)(in) + L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65814", "l": "A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA => 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749471", "l": "NLRX1 binds CHUK:IKBKB:IKBKG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22321", "l": "2 alpha-D-glucose 1-phosphate + H2O => D-maltose + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211904", "l": "CYP4F12 18-hydroxylates ARA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37018", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67942", "l": "2-oxooctanoate + H2O2 => 2-hydroxyoctanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64624", "l": "(2E)-geraniol + acetyl-CoA = (2E)-geranyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72557", "l": "estrone 3-sulfate(in) + propanoate(out) => estrone 3-sulfate(out) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58096", "l": "1-tetracosanoylglycerol + H2O = glycerol + H(+) + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12800", "l": "(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + scopolamine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49424", "l": "ATP + validone = ADP + H(+) + validone 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65579", "l": "a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate <=> an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28447", "l": "1-deoxy-D-xylulose(in) => 1-deoxy-D-xylulose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163625", "l": "Glucagon binds to Glucagon receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20402", "l": "a beta-lactam + H2O => a substituted beta-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975861", "l": "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865107", "l": "MICAL1 produces NADP+, H2O2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604712", "l": "Initial activation of proMMP7 by trypsin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43973", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13418", "l": "5,12-dihydroxanthommatin + NAD(+) => H(+) + NADH + xanthommatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60062", "l": "alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12274", "l": "CO2 + dopamine => H(+) + L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58912", "l": "ATP + H2O + iron(III) dicitrate(out) = ADP + H(+) + iron(III) dicitrate(in) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.18", "l": "\"ABC-type ferric citrate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13919", "l": "(1R,4S)-menthone + H(+) + NADPH => (-)-menthol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416516", "l": "GRK2 sequesters activated Gq (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357845", "l": "K63polyUb-RIPK1 is deubiquitinated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73806", "l": "AIR + CO2 => CAIR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008713", "l": "ADP-heptose-lipopolysaccharide heptosyltransferase activity", "d": ["Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018754", "l": "GDIs bind RHOH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44434", "l": "a 1,2-diacylglycerol + glycerol => 2 a 1-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694431", "l": "Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474210", "l": "Collagen type III degradation by MMP14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68038", "l": "(3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+) => (S)-cystathionine ketimine + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5674140", "l": "PAQR3 binds inactive RAFs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186798", "l": "GAP binds to PDGF-beta receptors only (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62207", "l": "1-propanol + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36944", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213241", "l": "Formation of nonameric complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62420", "l": "a (R)-2-hydroxy fatty acid + O2 = a fatty acid + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646685", "l": "Aggresome dissociates from dynein and microtubule (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26380", "l": "GTP <=> cyclic pyranopterin phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.914131229068573", "identifiers": [{"i": "GO:0016701", "l": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor."], "t": []}, {"i": "EC:1.13.-.-", "l": "\"Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated need not be derived from O2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770132", "l": "Formation of the Spliceosomal Pre-B complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013435", "l": "RHOD auto-activates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68176", "l": "2-oxoglutarate + N-geranyl-L-glutamate + O2 = CO2 + dainate A + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870269", "l": "Gastrin binds to CCK-B receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202328", "l": "Translocation of PKC theta to plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102296", "l": "4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity", "d": ["Catalysis of the reaction: (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O = 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071796", "l": "K6-linked polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362427", "l": "Hh-Np binds GPC5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62348", "l": "H(+) + NADPH + notoamide E + O2 = H2O + NADP(+) + notoamide C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66202", "l": "(2E)-pentenoyl-CoA + H2O2 => O2 + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56222", "l": "3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39331", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004361", "l": "glutaryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: glutaryl-CoA + 2 H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31302", "l": "H2O + NAD(+) + perillyl aldehyde <=> 2 H(+) + NADH + perillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-947499", "l": "Exchange of oxygen with sulfur in MoCo (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112395", "l": "Abortive termination of elongation after arrest (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114354", "l": "SMAC binds XIAP:Caspase-7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39164", "l": "3-oxohexadecanoyl-CoA + H(+) + NADPH => (3R)-hydroxyhexadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015341", "l": "zinc efflux active transmembrane transporter activity", "d": ["Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667657", "l": "NBEA binds NICD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9854961", "l": "SDHAF4 binds to FAD-SDHA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74049", "l": "L-alanine(out) + L-valine(in) => L-alanine(in) + L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63415", "l": "2,4,6-trichlorophenol + FADH2 + O2 <=> 2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696274", "l": "RND1 binds GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42137", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061750", "l": "acid sphingomyelin phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in an acidic environment."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45635", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024973", "l": "Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635861", "l": "NUMB:ITCH binds GLI1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56240", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22636", "l": "dCTP + H2O = dCMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950778", "l": "p-Y693-STAT4 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163551", "l": "triacylglycerol + H2O -> diacylglycerol + fatty acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166015", "l": "Association of LBP with LPS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983424", "l": "Budding of COPII coated vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169406", "l": "ISGylation of host proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373734", "l": "Nephrin interacts with Podocin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191763", "l": "snRNP:Snurportin complex formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35223", "l": "2-oxo-dADP + H2O = 2-oxo-dAMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9825759", "l": "MAPK-dependent phosphorylation of KARS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45906", "l": "dTDP + epivancomycin + H(+) => devancoaminyl-vancomycin + dTDP-beta-L-vancosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34244", "l": "GTP + H(+) + Mo-molybdopterin => diphosphate + Mo-molybdopterin guanine dinucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78098", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66587", "l": "3-oxocholestane + A + H2O <=> 25-hydroxy 3-oxocholestane + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50981", "l": "prostaglandin E1(out) => prostaglandin E1(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5660660", "l": "p300 acetylates RELA subunit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34032", "l": "2'-N-acetylparomamine + H2O => acetate + paromamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9842839", "l": "ATF7IP:SETDB1 binds SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68233", "l": "L-cysteine(in) + Na(+)(in) => L-cysteine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373074", "l": "Receptor CCR9  binds CCL25 ligand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828175", "l": "Formation of the NSL complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0019958", "l": "C-X-C chemokine binding", "d": ["Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849102", "l": "SRMS phosphorylates PTK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592297", "l": "Full activation of MMP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67714", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+) => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071172", "l": "dihydromonapterin reductase activity", "d": ["Catalysis of the reaction: 7,8-dihydromonapterin + NADPH = tetrahydromonapterin + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374909", "l": "Catabolism of Noradrenaline (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12899", "l": "(+)-8'-hydroxyabscisate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-cis-(+)-abscisate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662466", "l": "XYLB phosphorylates D-xylulose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11131", "l": "4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14841", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = ent-copalyl diphosphate", "d": [], "t": []}, {"i": "EC:5.5.1.13", "l": "\"ent-copalyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756574", "l": "SARS-CoV-2 S binds SFTPD 12mer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12803", "l": "ADP + H(+) + O-phospho-L-seryl-[tau protein] => ATP + L-seryl-[tau protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47031", "l": "[DsrC protein]-S-sulfo-L-cysteine/L-cysteine <=> [DsrC protein]-disulfide + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863472", "l": "DAB2 binds LRP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203979", "l": "Coat Assembly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001594", "l": "trace-amine receptor activity", "d": ["Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660706", "l": "Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12387", "l": "5,6-dihydrouracil + O2 <=> H2O2 + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46436", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417842", "l": "P2Y10 receptor can bind to LPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76876", "l": "H2O + hexan-2-amine + NAD(+) => H(+) + hexan-2-one + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8936442", "l": "MARC1,MARC2 reduce N-hydroxylated compounds (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987007", "l": "p-STAT1 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25509", "l": "(2E)-geranyl diphosphate => (1S,5S)-sabinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624158", "l": "Substrate:LAMP2a:HSP90 polymerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950398", "l": "CANX dissociates from IL27:EBI3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54332", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726580", "l": "PGR binds PGR agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48807", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14906", "l": "5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate => 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39219", "l": "3-oxooctacosanyol-CoA + H(+) + NADPH = (3R)-hydroxyoctacosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418456", "l": "cGMP is degraded by PDEs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39394", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH <=> (17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72165", "l": "chloride(in) + 2 Na(+)(in) + O-butanoyl-(R)-carnitine(in) => chloride(out) + 2 Na(+)(out) + O-butanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848110", "l": "SOCS3 binds activated PTK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654620", "l": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162363", "l": "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13629", "l": "(1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.243", "l": "\"carveol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714580", "l": "SLC6A3 binds DRIs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140808", "l": "NAD+-protein-tyrosine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-tyrosyl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]."], "t": []}, {"i": "RHEA:58236", "l": "L-tyrosyl-[protein] + NAD(+) = H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9633044", "l": "ESR binds STRN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23429", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32020", "l": "(2E,6E)-farnesyl diphosphate => beta-cubebene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009977", "l": "proton motive force dependent protein transmembrane transporter activity", "d": ["Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62278", "l": "6 AMP + beauvericin + 6 diphosphate + 6 H(+) + 3 S-adenosyl-L-homocysteine => 3 (R)-2-hydroxy-3-methylbutyrate + 6 ATP + 3 L-phenylalanine + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34990", "l": "(S)-lactate(in) <=> (S)-lactate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44212", "l": "3-hydroxytetradecanoate + ATP + CoA = 3-hydroxytetradecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833672", "l": "CDH11 forms heterotypic trans dimer with CDH8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604763", "l": "Autocatalytic activation of MMP7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78596", "l": "(3R)-hydroxyeicosanoyl-CoA + NAD(+) => 3-oxoeicosanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264615", "l": "Loading of acetylcholine in synaptic vesicles (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874191", "l": "CREB3L2 translocates from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789114", "l": "Hydroxyl radical reacts with the base and sugar moiety of DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39017", "l": "docosanedioate + 2 H(+) + NADH => 22-oxodocosanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008709", "l": "cholate 7-alpha-dehydrogenase activity", "d": ["Catalysis of the reaction: cholate + NAD+ = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74716", "l": "Insulin binds the insulin receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27837", "l": "a menaquinone + succinate <=> a menaquinol + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.435", "l": "\"L-fucose dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2201338", "l": "TRAF3 binds TICAM1:activated TLR4 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980051", "l": "DLL4 binds NOTCH2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.12", "l": "\"nepenthesin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16088", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031777", "l": "type 1 melanin-concentrating hormone receptor binding", "d": ["Binding to a type 1 melanin-concentrating hormone receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004572", "l": "mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602454", "l": "proMMP9 binds TIMP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6798743", "l": "Exocytosis of secretory granule membrane proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40294", "l": "ATP + CoA + tetradecanedioate <=> AMP + diphosphate + tetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36043", "l": "all-trans-8'-apo-beta-carotenal + O2 = 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial", "d": [], "t": []}, {"i": "EC:1.13.11.82", "l": "\"8'-apo-carotenoid 13,14-cleaving dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625196", "l": "Unfolded substrate in LAMP2a multimeric complex binds HSPA8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804266", "l": "CHEK2 phosphorylates TTC5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34804", "l": "2 4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA => bisdemethoxycurcumin + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64028", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine = H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47298", "l": "(2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein] => dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58588", "l": "dihydroprecondylocarpine acetate + NADPH = (+)-vincadifformine + acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44880", "l": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76022", "l": "cortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 18-hydroxycortisol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20790", "l": "ADP-alpha-D-ribose 1''-phosphate + H(+) + nicotinamide => NAD(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848250", "l": "ACBD6 binds LCFA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46055", "l": "a 3'-end uridylyl-uridine-RNA <=> a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51093", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173723", "l": "C8 binds C5b:C6:C7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.597073235812971", "identifiers": [{"i": "GO:0016818", "l": "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides", "d": ["Catalysis of the hydrolysis of any acid anhydride which contains phosphorus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39012", "l": "a triacyl-sn-glycerol(in) => a triacyl-sn-glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41928", "l": "(2E)-octadecenoyl-[ACP] + H(+) + NADPH = NADP(+) + octadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810843", "l": "Envoplakin binds periplakin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.161", "l": "\"beta-apiosyl-beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055054", "l": "fructose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose + H+ = fructose + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.10", "l": "\"steroid C-25 hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102213", "l": "in-chain hydroxy fatty acyl-CoA synthetase activity", "d": ["Catalysis of the reaction: coenzyme A + ATP + an in-chain hydroxy fatty acid = diphosphoric acid + AMP + a in-chain hydroxyacyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26501", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose <=> delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0086007", "l": "voltage-gated calcium channel activity involved in cardiac muscle cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18866", "l": "2-methylpropanoyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] => CoA + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71538", "l": "D-glucose 6-phosphate(in) + phosphate(out) <=> D-glucose 6-phosphate(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11448", "l": "NAD(+) + pregnan-21-ol = H(+) + NADH + pregnan-21-al", "d": [], "t": []}, {"i": "EC:1.1.1.150", "l": "\"21-hydroxysteroid dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43396", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol 3,4,5-triphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392752", "l": "Phosphorylation of L1 by CK-II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679145", "l": "Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71389", "l": "L-pipecolate(out) + Na(+)(out) => L-pipecolate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2089971", "l": "Secretion of collagens (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54465", "l": "1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66085", "l": "L-kynurenine + oxaloacetate => H2O + kynurenate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050472", "l": "zeatin reductase activity", "d": ["Catalysis of the reaction: dihydrozeatin + NADP+ = H+ + NADPH + zeatin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76806", "l": "2-aminopentan-1-ol + H2O + NAD(+) <=> 1-hydroxypentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004913", "l": "interleukin-4 receptor activity", "d": ["Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168405", "l": "Activated NOD oligomer recruites RIP2 (RICK) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218806", "l": "FYN autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879459", "l": "F-actin capping protein is a heterodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40995", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA = 4-hydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64991", "l": "CoA + H2O <=> (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10617", "l": "(2R,3S)-catechin + H2O + NADP(+) => (2R,3S,4S)-leucocyanidin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60887", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O <=> (N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848818", "l": "PTK6 phosphorylates CBL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73801", "l": "dehydroechinulin + diphosphate => dimethylallyl diphosphate + isoechinulin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64193", "l": "H2O + N-(9Z-octadecenoyl)-L-lysine => (9Z)-octadecenoate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199299", "l": "AKT phosphorylates FOXO transcription factors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170005", "l": "cyclic nucleotide phosphodiesterase activator activity", "d": ["Binds to and increases the activity of cyclic nucleotide phosphodiesterase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54558", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + diphosphate => a 5'-end ribonucleotide-tRNA(His) + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77113", "l": "1D-myo-inositol 1,2,3,6-tetrakisphosphate + phosphate => 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42425", "l": "2-methylmaleate + H2O => (2R,3S)-3-methylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418200", "l": "SRC-1 bound to ARRB2 is not activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032547", "l": "purine deoxyribonucleoside binding", "d": ["Binding to a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58237", "l": "L-tyrosyl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18799", "l": "a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68212", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol = 1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71755", "l": "2-oxoglutarate(out) + 2-oxoheptanedioate(in) = 2-oxoglutarate(in) + 2-oxoheptanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043776", "l": "cobalt-precorrin-6B C5-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047775", "l": "citramalate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50228", "l": "FADH2 + O2 + resorcinol = benzene-1,2,4-triol + FAD + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.27", "l": "\"resorcinol 4-hydroxylase (FADH2)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102440", "l": "3',4',5'-trimethylmyricetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine = 3,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29051", "l": "2 H(+)(in) + H2 + menaquinone-8 = 2 H(+)(out) + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696564", "l": "USP25 deubiquitinates DDX58 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706354", "l": "Ubiquitination of FLT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10456", "l": "acetyl-CoA + D-maltose = 1-O-acetylmaltose + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.79", "l": "\"maltose O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949580", "l": "F1Fo ATP synthase dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71797", "l": "(R)-3-hydroxybutanoate(in) + H(+)(in) => (R)-3-hydroxybutanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362549", "l": "Hh-Np traffics to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23054", "l": "ADP + H(+) + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] => ATP + L-seryl-[pyruvate dehydrogenase E1 alpha subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038386", "l": "Dimerization of FGFR3 t(4;14) translocation mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047422", "l": "N-acyl-D-aspartate deacylase activity", "d": ["Catalysis of the reaction: N-acyl-D-aspartate + H2O = D-aspartate + a carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712199", "l": "cAMP binds the olfactory CNG channel (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76842", "l": "H2O + NAD(+) + propylamine <=> H(+) + NADH + NH4(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10924", "l": "cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide", "d": [], "t": []}, {"i": "EC:5.2.1.10", "l": "\"2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428511", "l": "NCK binds ROBO1:SLIT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678854", "l": "S1PR1 binds S1PR1 agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69116", "l": "Formation of Okazaki fragments (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25967", "l": "(R)-benzoin + NADP(+) <=> benzil + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106268", "l": "3,5-dichloro-THPH methyl transferase activity", "d": ["Catalysis of the reaction: (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H+ + S-adenosyl-L-homocysteine."], "t": []}, {"i": "RHEA:48396", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683925", "l": "ULK1 is dephosphorylated (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43183", "l": "cytidine(2278) in 25S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2278) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112437", "l": "Formation of NELF complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12384", "l": "5,6-dihydrouracil + O2 = H2O2 + uracil", "d": [], "t": []}, {"i": "EC:1.3.3.7", "l": "\"dihydrouracil oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015207", "l": "adenine transmembrane transporter activity", "d": ["Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28537", "l": "dTTP + H2O <=> diphosphate + dTMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58463", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine <=> a monoacyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74973", "l": "L-leucine(in) + L-lysine(out) + Na(+)(in) => L-leucine(out) + L-lysine(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15867", "l": "4-hydroxytryptamine + A + H2O => AH2 + O2 + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990439", "l": "MAP kinase serine/threonine phosphatase activity", "d": ["Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018601", "l": "4-nitrophenol 2-monooxygenase activity", "d": ["Catalysis of the reaction: 4-nitrophenol + H+ + NADH + O2 = 4-nitrocatechol + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76947", "l": "3-methyl-2-aminobutane + H2O + NADP(+) = 3-methylbutan-2-one + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70839", "l": "L-arginine(in) + L-histidine(out) + Na(+)(out) = L-arginine(out) + L-histidine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58327", "l": "beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709547", "l": "ESTG binds ESR2:chaperone complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38975", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53012", "l": "2,5-dichlorohydroquinone + 2 glutathione = chloride + chlorohydroquinone + glutathione disulfide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-179410", "l": "Association of Nek2A with MCC:APC/C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17756", "l": "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine <=> (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21371", "l": "H2O + O2 + urate <=> 5-hydroxyisourate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429101", "l": "HMIT co-transports myo-inositol with a proton (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18694", "l": "a penicillin + H2O => 6-aminopenicillanate + a carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354124", "l": "Phosphorylation of pPTK2 by SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69650", "l": "H2O + quercetin 4'-O-beta-D-glucoside <=> beta-D-glucose + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162195", "l": "COQ4 decarboxylates MHDB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15075", "l": "D-glucuronate + N(2),6-disulfo-D-glucosamine => 3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28568", "l": "6 AMP + enterobactin + 7 H(+) => 3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77003", "l": "(4S)-4-hydroxy-L-arginine = H2O + L-enduracididine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52938", "l": "(3S)-hydroxy-3-methylglutaryl-[ACP] + H(+) + holo-[ACP] => 3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.135", "l": "\"N(4)-acetylcytidine amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.042693372152272", "identifiers": [{"i": "GO:0030247", "l": "polysaccharide binding", "d": ["Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44332", "l": "ATP + L-alanine + L-anticapsin = ADP + bacilysin + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.49", "l": "\"L-alanine--L-anticapsin ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64896", "l": "2 H2O + UTP = 2 H(+) + 2 phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46553", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350450", "l": "RHO1:GTP complex dissociates from RHOGEF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13585", "l": "ATP + butanoate = ADP + butanoyl phosphate", "d": [], "t": []}, {"i": "EC:2.7.2.7", "l": "\"butyrate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77356", "l": "2-oxobutanoate + L-alanine => (2S)-2-aminobutanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851988", "l": "BTN2A2 binds T cell surface (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42176", "l": "(9Z)-tetradecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-tetradecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77830", "l": "(2S)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O <=> 2-dehydro-D-glucose + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45415", "l": "H2O + prostaglandin D2-1-glycerol ester <=> glycerol + H(+) + prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39533", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41207", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55533", "l": "H(+) + H2O + L-phenylalanine + O2 => 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047296", "l": "homospermidine synthase activity", "d": ["Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46417", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55316", "l": "3 H2O + hydrogen sulfide + 3 NAD(+) = 4 H(+) + 3 NADH + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416690", "l": "SEMA4A binds to PLXND1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617207", "l": "SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36942", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA <=> (9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63763", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine <=> 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22971", "l": "butanal + CoA + NAD(+) <=> butanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.-", "l": "\"With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46069", "l": "(3E)-nonenoyl-CoA => (2E)-nonenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839746", "l": "Truncated AMER1 mutants destabilize the destruction complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50714", "l": "7-chlorotetracycline + FAD + H(+) + 2 H2O => chloride + FADH2 + O2 + tetracycline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351913", "l": "Caspase-mediated cleavage of TJP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51039", "l": "2 2-iminio-3-(indol-3-yl)propanoate + H2O2 <=> 2 H2O + indole-3-pyruvate imine dimer", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661625", "l": "FVIII is secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858498", "l": "SL (surrogate light chain) binds IgH to form pre-BCR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76455", "l": "(E)-coniferol + A = (E)-coniferaldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322427", "l": "Beta-catenin recruits CBP/p300 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837179", "l": "FASTKD5 binds 12S rRNA and mitochondrial mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72358", "l": "dehydroepiandrosterone 3-sulfate(out) + glutarate(in) <=> dehydroepiandrosterone 3-sulfate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53102", "l": "2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine => 2-hydroxyestrone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70001", "l": "L-threonine(out) + Na(+)(out) => L-threonine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47437", "l": "(2E,7Z)-hexadecadienoyl-CoA + H2O => (3S)-hydroxy-(7Z-hexadecenoyl)-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204871", "l": "Interaction of Tie2 and Grb2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141439", "l": "Release of activated MAD2 from kinetochores (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72444", "l": "(E)-feruloyl-AMP + CoA => (E)-feruloyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70215", "l": "cortisol + H(+) + NADPH = 20beta-dihydrocortisol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78113", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + CoA => an acyl-CoA + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034894", "l": "4-hydroxypyridine-3-hydroxylase activity", "d": ["Catalysis of the reaction: 4-hydroxypyridine + O2 + H+ + NADPH = pyridine-3,4-diol + H2O + NADP+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38121", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56701", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 => 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62687", "l": "norrubrofusarin + S-adenosyl-L-methionine <=> H(+) + rubrofusarin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696605", "l": "USP12, USP26 deubiquitinate AR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265177", "l": "Exocyst complex formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13513", "l": "(S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate", "d": [], "t": []}, {"i": "EC:1.3.1.14", "l": "\"dihydroorotate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799332", "l": "ATR phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917811", "l": "STEAP3,STEAP4 reduce Fe3+ to Fe2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9008043", "l": "MAPK8 phosphorylation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43310", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29767", "l": "ATP + D-methionine(out) + H2O = ADP + D-methionine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954185", "l": "ERBB4s80:TAB2:NCOR1 complex binds GFAP gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75156", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => diphosphate + verrucosan-2beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41816", "l": "a ganglioside GD3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GD2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.12", "l": "\"dCTP diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65533", "l": "2-methylbutan-1-ol + hexanoyl-CoA => 2-methylbutyl hexanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68732", "l": "ganoderate DM + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hainanate A + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980125", "l": "ITCH binds DTX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54621", "l": "2-oxoglutarate + eicosanoyl-CoA + O2 => 2-hydroxyeicosanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62906", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70184", "l": "2 alpha-isomaltosyl-(1->4)-D-maltotriose => alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029272", "l": "Release of PLCG from FCGR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6800298", "l": "HGF dimer binds MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209738", "l": "VD3 binds GC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30978", "l": "15-cis-phytoene + 5 A <=> 5 AH2 + all-trans-3,4-didehydrolycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14030", "l": "A + H2O + selenite => AH2 + selenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75626", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate <=> 14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.149", "l": "\"lycopene elongase/hydratase (flavuxanthin-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25204", "l": "D-ribulose 5-phosphate + formaldehyde <=> D-arabino-hex-3-ulose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140036", "l": "ubiquitin-modified protein reader activity", "d": ["A molecular adaptor recognizes and binds a target protein containing a ubiquitination modification and brings the target protein into contact with another protein to allow those proteins to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426032", "l": "DAG is metabolized by DAGL to 2-AG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222662", "l": "Nitric oxide enters the bacterium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615905", "l": "PIAS1 SUMOylates SATB1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75754", "l": "(9Z)-octadecenoate + H2O <=> 10-hydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11804", "l": "an aromatic aldehyde + H2O + NAD(+) = an aromatic carboxylate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.29", "l": "\"aryl-aldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086085", "l": "cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication", "d": ["Binding to a protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052687", "l": "(3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP + phosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA."], "t": []}, {"i": "KEGG.REACTION:R06396", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51393", "l": "(9Z)-octadecenoyl-CoA + serotonin => CoA + H(+) + N-(9Z-octadecenoyl)-serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051265", "l": "diolein transacylation activity", "d": ["Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870461", "l": "RABGGTA and RABGGTB bind (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60251", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] <=> AH2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824892", "l": "MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66636", "l": "(2E,6E)-farnesyl diphosphate + H2O = (-)-alpha-acorenol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047557", "l": "3-aci-nitropropanoate oxidase activity", "d": ["Catalysis of the reaction: 3-aci-nitropropanoate + H2O + O2 = 3-oxopropanoate + H2O2 + nitrite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23432", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.52", "l": "\"(S)-limonene 7-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51787", "l": "4-prenylphlorisovalerophenone + dimethylallyl diphosphate <=> deoxyhumulone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070006", "l": "metalloaminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034813", "l": "benzo(a)pyrene 7,8-dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-7,8-dihydrodiol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74801", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61184", "l": "quercitrin + UDP-beta-L-rhamnose = H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25156", "l": "(R)-4'-phosphopantothenate + ATP + L-cysteine = AMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": [], "t": []}, {"i": "EC:6.3.2.51", "l": "\"phosphopantothenate--cysteine ligase (ATP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41988", "l": "3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31013", "l": "camelliol C => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52454", "l": "16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008476", "l": "RUNX2 binds GSK3B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14717", "l": "D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.54", "l": "\"3-deoxy-7-phosphoheptulonate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78147", "l": "a 1,3-diacylglycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26086", "l": "(4S)-limonene + H(+) + NADPH + O2 => H2O + limonene 1,2-epoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062058", "l": "transcription factor TFIIH holo complex binding", "d": ["Binding to a transcription factor TFIIH holo complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0009389", "l": "dimethyl sulfoxide reductase activity", "d": ["Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19014", "l": "dTTP + H2O => dTDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164834", "l": "Enzyme-bound ATP is released (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806629", "l": "Formation of tonofilament bundles (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77087", "l": "isochorismoyl-L-glutamate = N-pyruvoyl-L-glutamate + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61441", "l": "acetyl-CoA + S-(2-succino)-L-cysteine => CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863472", "l": "DAB2 binds LRP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50213", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41927", "l": "(3R)-hydroxyoctadecanoyl-[ACP] <=> (2E)-octadecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42318", "l": "an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36818", "l": "dTDP-alpha-D-fucose <=> dTDP-alpha-D-fucofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75291", "l": "glyoxylate(in) + oxalate(out) = glyoxylate(out) + oxalate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672948", "l": "MARK3 phosphorylates KSR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48364", "l": "beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22761", "l": "Cypridina luciferin + O2 => CO2 + hnu + oxidized Cypridina luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9864415", "l": "AAC1 imports a proton (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811412", "l": "Active ARF recruits coatomer to the Golgi (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.4", "l": "\"3-oxosteroid 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75618", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate <=> ectocarpin B + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68074", "l": "L-thiazolidine-2-carboxylate + NADP(+) => Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112429", "l": "Formation of FACT complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45750", "l": "(2E)-hexenoyl-CoA => (3Z)-hexenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985627", "l": "RUNX2 and RB1 bind the COL1A1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362793", "l": "Hh-Np is cleaved by ADAM17 to promote ligand shedding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26535", "l": "3-hydroxypropanoate + ATP + CoA => 3-hydroxypropanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389532", "l": "PP2A binds CTLA4 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40951", "l": "(2S)-2-acetamido-4-aminobutanoate + H2O = acetate + L-2,4-diaminobutanoate", "d": [], "t": []}, {"i": "EC:3.5.1.125", "l": "\"N(2)-acetyl-L-2,4-diaminobutanoate deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878056", "l": "RUNX1:CBFB binds EP300 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61600", "l": "[DsbD protein]-disulfide + [protein]-dithiol = [DsbB protein]-dithiol + [protein]-disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45907", "l": "devancoaminyl-vancomycin + dTDP-beta-L-vancosamine <=> dTDP + epivancomycin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38565", "l": "1-O-hexadecyl-sn-glycerol + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71002", "l": "(S)-nicotine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-nornicotine + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102584", "l": "cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP-alpha-D-glucose = cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047612", "l": "acid-CoA ligase (GDP-forming) activity", "d": ["Catalysis of the reaction: a carboxylate + CoA + GTP = acyl-CoA + GDP + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49526", "l": "a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44987", "l": "(R)-carnitine + 3-methylbutanoyl-CoA <=> CoA + O-3-methylbutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865182", "l": "OTUD7A hydrolyses K11diUb (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9669893", "l": "KIT binds type I TKIs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29036", "l": "ATP + H2O + L-glutamate(out) => ADP + H(+) + L-glutamate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714483", "l": "RAC2 translocates to the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15860", "l": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) <=> 17alpha-hydroxyprogesterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70742", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694583", "l": "ABHD4 hydrolyses NAPE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0061995", "l": "ATP-dependent protein-DNA complex displacement activity", "d": ["An activity that displaces proteins or protein complexes from DNA, sometimes in a 'wire stripping' fashion, driven by ATP hydrolysis."], "t": []}, {"i": "REACT:R-HSA-9822115", "l": "NPM2 dissociates p-S9-PRM1 from HIRA:NPM2:p-S9-PRM1:dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64022", "l": "GDP + H(+) + O-phospho-L-seryl-[protein] => GTP + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76077", "l": "a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in) => a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769397", "l": "SOST binds LRP5/6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43291", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964274", "l": "G alpha (12) binds BTK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37144", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.7", "l": "\"glutamyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9856871", "l": "MDH1 reduces OA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177926", "l": "Dephosphorylation of PAG by SHP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40153", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+) => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682388", "l": "Autophagosome maturation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49129", "l": "AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13137", "l": "cycloartenol + S-adenosyl-L-methionine = cyclolaudenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.142", "l": "\"cycloartenol 24-C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48794", "l": "alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => GDP-beta-L-fucose + Lc4Cer", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532603", "l": "Nephrin mediated activation of N-WASP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10427", "l": "H2O + N-benzoylglycine <=> benzoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49861", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209960", "l": "Diiodinated tyrosine can be deiodinated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64759", "l": "H2O + S-benzyl-L-cysteine <=> benzylthiol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607722", "l": "Active NIK phosphorylates IKKA dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21531", "l": "[phosphate](n) + H2O <=> [phosphate](n-1) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080075", "l": "spermidine:feruloyl CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of a feruloyl group to a nitrogen atom on the spermidine molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098848", "l": "alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity", "d": ["Catalysis of the reaction: alpha-D-ribose 1-methylphosphonate 5-phosphate = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66049", "l": "2-oxobutanoate + L-kynurenine => (2S)-2-aminobutanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.20", "l": "\"DNA-3-methyladenine glycosylase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45291", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 <=> 2-glyceryl-prostaglandin G2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67066", "l": "A + asnovolin A => AH2 + asnovolin K", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693347", "l": "CRYM reduces P2C to PPCA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103106", "l": "brassinolide 23-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: brassinolide + UDP-alpha-D-glucose = brassinolide-23-O-glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45326", "l": "H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine => H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48279", "l": "H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide <=> a beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002952", "l": "(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity", "d": ["Catalysis of the reaction (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione = 3-hydroxy-5-phosphonooxypentane-2,4-dione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41101", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16976", "l": "2-hydroxypyridine + AH2 + O2 <=> 2,5-dihydroxypyridine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111970", "l": "PKC phosphorylates GRK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68780", "l": "(2Z,6Z)-farnesyl diphosphate = alpha-humulene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378952", "l": "Thyrotropin is a heterodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47642", "l": "4 H(+) + N(6)-dimethyladenosine(1785)/N(6)-dimethyladenosine(1786) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1785)/adenosine(1786) in 18S rRNA + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.108", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34907", "l": "molybdate(in) = molybdate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004148", "l": "dihydrolipoyl dehydrogenase activity", "d": ["Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42566", "l": "pseudouridine(38/39) in tRNA => uridine(38/39) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72841", "l": "ADP(in) + CoA(out) => ADP(out) + CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74500", "l": "H(+) + NADPH + yaequinolone D => H2O + NADP(+) + penigequinolone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38807", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0042802", "l": "identical protein binding", "d": ["Binding to an identical protein or proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67670", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24154", "l": "3'-phosphoadenylyl sulfate + ADP + H(+) => adenosine 5'-phosphosulfate + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72339", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + guaiacol + H(+) = catechol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74244", "l": "H2O + L-alanyl-tRNA(Pro) => H(+) + L-alanine + tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23226", "l": "H(+) + O-beta-D-glucosyl-trans-zeatin + UDP => trans-zeatin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210290", "l": "Interaction of PECAM-1 and SHIP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.217", "l": "\"protodeoxyviolaceinate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78889", "l": "D-glucose + N-deacetylisoipecoside aglycone => H2O + N-deacetylisoipecoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35681", "l": "3-oxotetradecasphinganine + CO2 + CoA => dodecanoyl-CoA + H(+) + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211951", "l": "CYP1B1 4-hydroxylates EST17b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189488", "l": "UROS transforms HMB to URO3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473596", "l": "Collagen type I degradation by MMP15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31067", "l": "6-amino-2-oxohexanoate = Delta(1)-piperideine-2-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199014", "l": "CD96 binds PVR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700200", "l": "PTPRZ dephosphorylates ligand-bound ALK dimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111966", "l": "GRK2 binds CALM1:4Ca2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48313", "l": "benzoyl-CoA + H(+) + NADPH + O2 => 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395965", "l": "NUDT18 hydrolyses 8-oxo-dADP to 8-oxo-dAMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28885", "l": "H(+)(out) + L-threonine(out) => H(+)(in) + L-threonine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003831", "l": "beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870465", "l": "RGGT binds the RAB-binding subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.7", "l": "\"aldehyde dehydrogenase (FAD-independent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358789", "l": "Self-ubiquitination of RNF41 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047599", "l": "8-oxocoformycin reductase activity", "d": ["Catalysis of the reaction: coformycin + NADP+ = 8-oxocoformycin + 2 H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9015111", "l": "Factor Xa inhibitors binds Xa (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51506", "l": "a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP => a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3321883", "l": "MSL acetylates histone H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65237", "l": "3-methylbutanol + acetyl-CoA => 3-methylbutyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20365", "l": "phosphoethanolamine + S-adenosyl-L-methionine = H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63098", "l": "ilicicolin C => ilicicolin A epoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28932", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate => 4-carboxy-2-hydroxy-cis,cis-muconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77038", "l": "(2S)-heptan-2-amine + H2O + NAD(+) <=> H(+) + heptan-2-one + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69685", "l": "CHEK2 phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69127", "l": "Formation of the Flap Intermediate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36639", "l": "3-O-phospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-methionine = 3-O-methylphospho-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.294", "l": "\"3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57015", "l": "a menaquinone + H2O + sulfite <=> a menaquinol + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45185", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73693", "l": "3'-AMP(in) + phosphate(out) => 3'-AMP(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380782", "l": "STAT binds to the active receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71414", "l": "3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48045", "l": "ganglioside GM1 (d18:1(4E)/18:0) + H2O => D-galactose + ganglioside GM2 (d18:1(4E)/18:0)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727819", "l": "TAK1 phosphorylates MKK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395324", "l": "Formation of hydroxylysyl-pyrrole cross-links (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029471", "l": "Hydrolysis of PC to PA by PLD (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045552", "l": "dihydrokaempferol 4-reductase activity", "d": ["Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0005534", "l": "galactose binding", "d": ["Binding to aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19060", "l": "a hydroperoxy polyunsaturated fatty acid + 2 glutathione <=> a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33395", "l": "H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester = GMP + N(alpha)-acetyl-L-lysine methyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19430", "l": "[beta-adrenergic receptor] + ATP => [beta-adrenergic receptor]-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222020", "l": "NUAK1 phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2172666", "l": "RB1 binds condensin II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2509827", "l": "ITPA hydrolyses ITP to IMP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75270", "l": "D-arabinose + NADP(+) <=> D-arabinono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031703", "l": "type 2 angiotensin receptor binding", "d": ["Binding to a type 2 angiotensin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30573", "l": "6 AMP + 6 diphosphate + enterobactin + 4 H(+) => 3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61352", "l": "ATP + H2O + riboflavin(in) = ADP + H(+) + phosphate + riboflavin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018482", "l": "4-formylbenzenesulfonate dehydrogenase activity", "d": ["Catalysis of the reaction: 4-formylbenzenesulfonate + H2O + NAD+ = 4-sulfobenzoate + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68768", "l": "4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981931", "l": "RAC1 and CDC42 activate PAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22799", "l": "ATP + D-hamamelose <=> ADP + D-hamamelose 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53855", "l": "glycocholate + NAD(+) <=> 7-oxo-glycodeoxycholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41250", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48516", "l": "1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730884", "l": "Phosphorylation of NTAL by p-SYK/Lyn (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871260", "l": "YAP1 binds TEAD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28282", "l": "(S)-beta-bisabolene = (S)-beta-macrocarpene", "d": [], "t": []}, {"i": "EC:5.5.1.17", "l": "\"(S)-beta-macrocarpene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25463", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sibirene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036140", "l": "[protein]-asparagine 3-dioxygenase activity", "d": ["Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676257", "l": "Formation of the SET1A complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013006", "l": "RHOA:GTP translocates to the ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008759", "l": "UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity", "d": ["Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420233", "l": "VIP receptors bind VIP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166792", "l": "Conversion of C2 into C2a and C2b (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46732", "l": "(2R,6)-dimethylheptanoyl-CoA = (2S,6)-dimethylheptanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33149", "l": "ADP + daunorubicin(out) + H(+) + phosphate => ATP + daunorubicin(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23884", "l": "nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.1", "l": "\"nicotinamide N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55681", "l": "(2S)-2-amino-4-deoxychorismate => anthranilate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28628", "l": "O2 + reduced [NADPH--hemoprotein reductase] + solavetivol => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "60.028426816308652", "identifiers": [{"i": "GO:0016798", "l": "hydrolase activity, acting on glycosyl bonds", "d": ["Catalysis of the hydrolysis of any glycosyl bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167415", "l": "G-protein alpha subunit is inactivated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39574", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36948", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106615", "l": "Removal of siRNA passenger strand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676595", "l": "TRAFs bind RANK:RANKL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656947", "l": "OGG1beta translocates to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45679", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63660", "l": "(8S)-8-amino-7-oxononanoate + CO2 + L-lysyl-[protein] = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.6.1.121", "l": "\"8-amino-7-oxononanoate carboxylating dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172194", "l": "Recruitment of PLK1 to phosphorylated GORASP1 (GRASP65) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052754", "l": "GTP:coenzyme F420 guanyltransferase activity", "d": ["Catalysis of the reaction: GTP + factor gamma-F420-2 + H+ = coenzyme F390-G + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43424", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174119", "l": "Free APC/C phosphorylated by Plk1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28770", "l": "ethylnitronate + O2 <=> acetaldehyde + chemical entity + H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58067", "l": "O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin <=> 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5626938", "l": "Beta-catenin binds SOX proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061787", "l": "peptidoglycan cross-bridge peptide endopeptidase activity", "d": ["A peptidoglycan endopeptidase activity that acts on a peptidoglycan cross-bridge."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75248", "l": "acetyl-CoA + N-terminal L-prolyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-prolyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23753", "l": "all-trans-undecaprenol + ATP => ADP + all-trans-undecaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977271", "l": "Expression of EBF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956427", "l": "RETSAT reduces atROL to at-13,14-dhROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74737", "l": "p-Y-IRS1,p-Y-IRS2 bind PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77664", "l": "1-O-alkyl-3-acylglycerol + an acyl-CoA => 1-O-alkyl-2,3-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48483", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose <=> 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24951", "l": "3-hydroxy-3-methylglutarate + malonyl-CoA <=> (3S)-hydroxy-3-methylglutaryl-CoA + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374663", "l": "DCC interaction with Ezrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23825", "l": "(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) => 2,3-dihydroxybenzoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193482", "l": "25(R) DHCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64181", "l": "an N-(fatty acyl)-L-tryptophan + H2O => a fatty acid + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47178", "l": "(2E)-butenoyl-CoA + H2O => (2R)-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65195", "l": "2 2-oxoglutarate + 2 O2 + preaustinoid A <=> berkeleytrione + 2 CO2 + H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52744", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + H2O = alpha-isomaltosyl-(1->3)-isomaltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74242", "l": "phosphate + solabiose <=> alpha-D-glucose 1-phosphate + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21854", "l": "(9Z)-octadecenoate + H2O => (R)-10-hydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086040", "l": "sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential", "d": ["Enables the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.4", "l": "\"trypsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19034", "l": "an N-acyl-D-glucosamine => an N-acyl-D-mannosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16809", "l": "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate", "d": [], "t": []}, {"i": "EC:4.1.3.30", "l": "\"methylisocitrate lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52593", "l": "deoxycholoyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59498", "l": "(20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52130", "l": "a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+) => a 5'-end adenosine-5'-diphospho-5'-2'-deoxyribonucleoside-DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106614", "l": "Duplex miRNA is loaded into Argonaute (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25031", "l": "ADP-D-ribose + phosphate => ADP-alpha-D-ribose 1''-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62295", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55521", "l": "dimethylallyl diphosphate + 3 isopentenyl diphosphate => 3 diphosphate + nerylneryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66690", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + A + acetone + H(+) + H2O => 4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53923", "l": "ATP + L-threonyl-[Fas-activated protein] <=> ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928657", "l": "MMP2,9 cleave EPHB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72939", "l": "2 Na(+)(out) + propanoate(out) = 2 Na(+)(in) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694435", "l": "MIA2 and MIA3 load procollagen VII into COPII vesicles (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694441", "l": "CSNK1D phosphorylates SEC23 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375140", "l": "CDO binds promyogenic cadherins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57911", "l": "ATP + L-glutamyl-tRNA(Gln) <=> 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17890", "l": "H2O + phosphoethanolamine => acetaldehyde + NH4(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16965", "l": "(2E)-geranyl diphosphate = beta-myrcene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.15", "l": "\"myrcene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55976", "l": "glutathione + thiosulfate = H(+) + S-sulfanylglutathione + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.40", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51377", "l": "dopamine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665871", "l": "ADRM1 binds 26S proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72683", "l": "cholate(out) = cholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24055", "l": "a ubiquinone + reduced [electron-transfer flavoprotein] <=> a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54452", "l": "a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350395", "l": "RHOGDI binds to and sequesters RHO1:GDP complex to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784324", "l": "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69854", "l": "a 5,6-dihydrouridine in mRNA + NAD(+) <=> a uridine in mRNA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64201", "l": "an N-(fatty acyl)-L-leucine + H2O => a fatty acid + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022378", "l": "ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111956", "l": "Calmodulin activates Cam-PDE 1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64157", "l": "an N-(fatty acyl)-L-methionine + H2O => a fatty acid + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29209", "l": "a menaquinone(in) + dimethyl sulfide(out) + H2O(out) => a menaquinol(in) + dimethyl sulfoxide(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39156", "l": "(3R)-hydroxyoctadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35326", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74897", "l": "nitric oxide(in) => nitric oxide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69022", "l": "H2O + N-hydroxy-L-aspartate + NADP(+) => L-aspartate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34962", "l": "(R)-carnitine(in) <=> (R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28848", "l": "Li(+)(in) + melibiose(in) => Li(+)(out) + melibiose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40861", "l": "(2E,9Z)-hexadecadienoyl-CoA + FADH2 => (9Z)-hexadecenoyl-CoA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52645", "l": "D-xylono-1,4-lactone 5-phosphate + H2O => 5-phospho-D-xylonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901584", "l": "tetrapeptide transmembrane transporter activity", "d": ["Enables the transfer of tetrapeptide from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813626", "l": "LEAP2 binds bacteria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624131", "l": "UNC119B binds myristoylated proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018674", "l": "(S)-limonene 3-monooxygenase activity", "d": ["Catalysis of the reaction: (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,6R)-isopiperitenol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71825", "l": "G6PC hydrolyzes G6P to Glc and Pi (liver) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662606", "l": "MT3 binds zinc (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9824882", "l": "IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9828175", "l": "Formation of the NSL complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349455", "l": "Phosphorylation of MDM4 by ATM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42588", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15474", "l": "flavanone 7-O-beta-D-glucoside + UDP-beta-L-rhamnose => flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22157", "l": "GDP + H2O => GMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010295", "l": "(+)-abscisic acid 8'-hydroxylase activity", "d": ["Catalysis of the reaction: (+)-abscisate + H+ + NADPH + O2 = (+)-8'-hydroxyabscisate + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33081", "l": "adenine + dehypoxanthine futalosine => 6-amino-6-deoxyfutalosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51845", "l": "(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.9", "l": "\"[Goodpasture-antigen-binding protein] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41807", "l": "3-oxobutanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxybutanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14499", "l": "AH2 + isopyridoxal => A + pyridoxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45332", "l": "7,8-dihydroneopterin + O2 = 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.81", "l": "\"7,8-dihydroneopterin oxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352174", "l": "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43459", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl-CoA <=> (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77569", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30295", "l": "GTP + pyruvate = GDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44255", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17557", "l": "anthranilate + malonyl-CoA = CoA + N-malonylanthranilate", "d": [], "t": []}, {"i": "EC:2.3.1.113", "l": "\"anthranilate N-malonyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398184", "l": "LARG activation by G alpha 12/13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29868", "l": "AMP + ITP => ADP + IDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690669", "l": "CD22 binds itself to form homo-oligomers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16246", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0002060", "l": "purine nucleobase binding", "d": ["Binding to a purine nucleobase, an organic nitrogenous base with a purine skeleton."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19291", "l": "phosphate + sucrose => H2O + sucrose 6(F)-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50421", "l": "L-leucyl-tRNA(Leu) + N-terminal L-aspartyl-[protein] => H(+) + N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73177", "l": "ADP(out) + FMN(in) => ADP(in) + FMN(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51720", "l": "ATP(in) + CoA(in) + H(+)(out) + octadecanoate(out) = AMP(in) + diphosphate(in) + H(+)(in) + octadecanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58580", "l": "dihydroprecondylocarpine acetate = acetate + catharanthine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825422", "l": "P protein oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68540", "l": "(2Z,6Z)-farnesyl diphosphate = (-)-alpha-cedrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38020", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol => 1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29960", "l": "alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-galactose => alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.354970481220079", "identifiers": [{"i": "GO:0015923", "l": "mannosidase activity", "d": ["Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37788", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250947", "l": "B-WICH complex binds rDNA promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391941", "l": "BLT receptors can bind LTB4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102065", "l": "patchoulene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphoric acid + gamma-patchoulene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714691", "l": "RAC3 binds ER effectors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20348", "l": "[thioredoxin]-dithiol + NADP(+) <=> [thioredoxin]-disulfide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874080", "l": "SRC phosphorylates PTK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22699", "l": "AH2 + androst-4-ene-3,17-dione + O2 <=> A + H2O + testololactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168459", "l": "Lyn activates ERK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425861", "l": "Activation of Protein Kinase C novel isoforms (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71318", "l": "chloride(out) + L-serine(out) + 2 Na(+)(out) <=> chloride(in) + L-serine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36855", "l": "an N-acetyl-L-cysteine-S-conjugate + H2O = acetate + an S-substituted L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419334", "l": "Melatonin receptors can bind melatonin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080131", "l": "hydroxyjasmonate sulfotransferase activity", "d": ["Catalysis of the reaction: a hydroxyjasmonate + 3'-phosphoadenosine-5'-phosphosulfate = a hydroxyjasmonate sulfate + adenosine-3',5'-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938108", "l": "SERPINB13 binds cathepsin L (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614654", "l": "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19973", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + spermine", "d": [], "t": []}, {"i": "EC:2.5.1.22", "l": "\"spermine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877620", "l": "ECE2 cleaves EDN1(53-90) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10135", "l": "ATP + benzoate + CoA <=> AMP + benzoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2530429", "l": "Formation of soluble VTN:C5b-C9  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674019", "l": "BRAP binds KSR1:MARK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36128", "l": "gibberellin A34 + S-adenosyl-L-methionine => O-methyl gibberellin A34 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45953", "l": "L-asparaginyl-[protein] + UDP-alpha-D-glucose => H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976801", "l": "Complement factor I complex formation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76369", "l": "n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(in) => n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13811", "l": "aspulvinone H + 2 diphosphate => aspulvinone E + 2 dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030107", "l": "HLA-A specific inhibitory MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28037", "l": "[thioredoxin]-disulfide + dADP + H2O <=> [thioredoxin]-dithiol + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39819", "l": "docosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2-hydroxydocosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50617", "l": "NADP(+) + nonan-2-one => (3E)-nonen-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56976", "l": "4-methylphenol + H2O + 2 oxidized [azurin] = 4-hydroxybenzyl alcohol + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0052880", "l": "oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a copper protein."], "t": []}, {"i": "EC:1.10.9.-", "l": "\"With a copper protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909729", "l": "Activation of JAK kinases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793666", "l": "MDM2 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68832", "l": "(2Z,6Z)-farnesyl diphosphate + H2O = (6Z)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42062", "l": "11-cis-retinal + H(+) + NADH => 11-cis-retinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64804", "l": "acetyl-CoA + S-(2-aminoethyl)-L-cysteine = CoA + H(+) + S-(2-acetamidoethyl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51922", "l": "A + a quinol => a quinone + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23185", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate => (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.47", "l": "\"8-amino-7-oxononanoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76139", "l": "D-gluconate(in) = D-gluconate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1017228", "l": "Glycoproteins with lesser folding defects get transported back to the ER and the CNX/CRT complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45548", "l": "phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]", "d": [], "t": []}, {"i": "EC:4.4.1.33", "l": "\"R-phycocyanin alpha-cysteine-84 phycourobilin lyase/isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21027", "l": "CoA + glyoxylate + NADP(+) <=> H(+) + NADPH + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018483", "l": "6-oxohexanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54304", "l": "n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate = n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54423", "l": "3',3'-c-di-AMP + H2O <=> 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72292", "l": "2,3-dimethylsuccinate(out) + 3 Na(+)(out) => 2,3-dimethylsuccinate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11461", "l": "ADP + D-glucose => AMP + D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73277", "l": "4',7,8-trihydroxy-3'-methoxyflavone-7-olate + H(+) + S-adenosyl-L-homocysteine => 3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71972", "l": "3-hydroxyglutarate(out) + 3 Na(+)(out) => 3-hydroxyglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0004363", "l": "glutathione synthase activity", "d": ["Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11110", "l": "n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+) => n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677051", "l": "Formation of the PCAF-ATAC complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48919", "l": "a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GD1c + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34619", "l": "1-deoxypentalenate + 2-oxoglutarate + O2 = 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.35", "l": "\"1-deoxypentalenic acid 11beta-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75975", "l": "(S)-stylopine + S-adenosyl-L-methionine = (S)-cis-N-methylstylopine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64418", "l": "D-xylono-1,4-lactone + H(+) + NADPH => D-xylofuranose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12337", "l": "carboxymethoxysuccinate => fumarate + glycolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64111", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140769", "l": "factor VII -> factor VIIa (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857329", "l": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72407", "l": "H(+)(in) + Li(+)(out) = H(+)(out) + Li(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53946", "l": "(2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH => 2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67619", "l": "8-oxo-GTP + H2O <=> 8-oxo-GMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785762", "l": "IL13RA1 binds TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033423", "l": "CCA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CCA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166072", "l": "MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62840", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191784", "l": "snRNA Cap hypermethylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35287", "l": "ATP + chloramphenicol(in) + H2O = ADP + chloramphenicol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59460", "l": "hexadecan-1-ol + NADP(+) = H(+) + hexadecanal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15020", "l": "a phosphate monoester + H2O <=> an alcohol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985343", "l": "RUNX2 binds SOX9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66074", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine => 4-methyl-2-oxopentanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061891", "l": "calcium ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of calcium ions (Ca2+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33454", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] <=> AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37017", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5604954", "l": "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21107", "l": "AH2 + cholesterol + O2 <=> 25-hydroxycholesterol + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63952", "l": "a sphingoid 1-phosphate + H2O = a sphingoid base + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0000107", "l": "imidazoleglycerol-phosphate synthase activity", "d": ["Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211951", "l": "CYP1B1 4-hydroxylates EST17b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004127", "l": "(d)CMP kinase activity", "d": ["Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67180", "l": "ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43261", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65622", "l": "CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine => hexadecanoyl-CoA + sphinga-(4E,8E)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18286", "l": "an N-acyl-D-aspartate + H2O => a carboxylate + D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20662", "l": "D-alanyl-D-alanine + H2O => 2 D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050699", "l": "WW domain binding", "d": ["Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9029680", "l": "Caspase-7 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40247", "l": "H2O + rhodomycin D = 10-carboxy-13-deoxycarminomycin + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46511", "l": "NADH + nitrobenzene + O2 <=> catechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042958", "l": "maltodextrin transmembrane transporter activity", "d": ["Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.25", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031217", "l": "glucan 1,4-beta-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57166", "l": "(3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-435375", "l": "ZnT2 facilitates zinc vesicular sequestration (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46672", "l": "aldosterone + H(+) + NADPH = 5beta-dihydroaldosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371554", "l": "HSF1 acetylation at Lys80 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29369", "l": "cytidine + phosphate => CMP + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781953", "l": "YOD1 binds VCP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62863", "l": "acetyl-CoA + 7 H(+) + 7 malonyl-CoA <=> 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20714", "l": "(8S)-8-amino-7-oxononanoate + CO2 + CoA => 6-carboxyhexanoyl-CoA + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35303", "l": "3-hydroxyisopentadecanoyl-CoA + NADP(+) = 3-oxoisopentadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16258", "l": "alpha,alpha-trehalose + phosphate => alpha-D-glucose + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62333", "l": "ADP + ATP => adenosine 3'-diphosphate,5'-diphosphate + AMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.23", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9857359", "l": "MITF-M dimer binds the BIRC7 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008481", "l": "sphinganine kinase activity", "d": ["Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29309", "l": "FMN + formaldehyde + 2 H(+) + H2O + sulfite => FMNH2 + methanesulfonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23211", "l": "acetyl-CoA + trans-glutaconate <=> (2E)-glutaconyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71391", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141437", "l": "Formation of the MCC complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750555", "l": "NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014467", "l": "RHOG binds effectors at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043882", "l": "malate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + Na+(out) = malate(in) + Na+(in)."], "t": []}, {"i": "RHEA:72295", "l": "malate(out) + 3 Na(+)(out) = malate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63555", "l": "angiotensin-(1-7) + H2O <=> angiotensin-(1-5) + L-histidyl-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762345", "l": "PREDN:ALB dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77961", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a triacylglycerol => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731931", "l": "EDNRA binds selective ERAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17901", "l": "S-adenosyl-L-methionine + xanthotoxol = H(+) + S-adenosyl-L-homocysteine + xanthotoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42745", "l": "guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.752469279128519", "identifiers": [{"i": "GO:0016840", "l": "carbon-nitrogen lyase activity", "d": ["Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)."], "t": []}, {"i": "EC:4.3.-.-", "l": "\"Carbon-nitrogen lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13934", "l": "all-trans-retinyl hexadecanoate + H2O => all-trans-retinol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65864", "l": "5alpha-androst-1-ene-3,17-dione + A + H2O = 5alpha-androstan-1,3,17-trione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18379", "l": "ADP + H(+) + streptomycin 3''-phosphate => ATP + streptomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15845", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}, {"i": "EC:2.4.1.52", "l": "\"poly(glycerol-phosphate) alpha-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.8", "l": "\"3-phytase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11289", "l": "dihydromacarpine + H(+) + O2 => H2O2 + macarpine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030798", "l": "trans-aconitate 2-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690873", "l": "ACO1 binds 4Fe-4S (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43223", "l": "guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158399", "l": "kallikrein binds SERPING1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46573", "l": "2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357445", "l": "PAK1-3 dimer disassociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007561", "l": "E2F1 binds RAD51 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592233", "l": "p38 MAPK phosphorylates PPARGC1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69873", "l": "(22S)-22-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholestanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693590", "l": "SARS-CoV-1 dsRNA intermediates bind IFIH1:TKFC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49068", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18487", "l": "acetate + D-glucose + H(+) => 6-acetyl-D-glucose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57373", "l": "H2O + NADPH => (6S)-NADPHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60918", "l": "an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.299", "l": "\"protein N-terminal monomethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694442", "l": "CNIH2,3 bind GRIA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54125", "l": "coelenterazine h dioxetanone => CO2 + excited coelenteramide h monoanion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34178", "l": "2-hydroxybenzoyl-CoA + malonyl-CoA <=> 4-hydroxycoumarin + CO2 + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "61.48456739527483", "identifiers": [{"i": "GO:0016835", "l": "carbon-oxygen lyase activity", "d": ["Catalysis of the breakage of a carbon-oxygen bond."], "t": []}, {"i": "EC:4.2.-.-", "l": "\"Carbon-oxygen lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41009", "l": "6-linalyl-2-O,3-dimethylflaviolin + diphosphate => (2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30645", "l": "hypoxanthine + S-methyl-5-thio-alpha-D-ribose 1-phosphate => phosphate + S-methyl-5'-thioinosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617138", "l": "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120092", "l": "crotonyl-CoA hydratase activity", "d": ["Catalysis of the reaction: Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine."], "t": []}, {"i": "RHEA:45584", "l": "3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833723", "l": "PKR forms a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362437", "l": "C-terminal Hh fragments are bound by lectins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4724279", "l": "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624272", "l": "MMPs cleave HB-EGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52832", "l": "1-hydroxylimonen-2-one + H(+) + NADPH + O2 = 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58590", "l": "(+)-vincadifformine + acetate + NADP(+) => dihydroprecondylocarpine acetate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815510", "l": "MIB2 binds CYLD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43367", "l": "L-erythro-N-acylsphing-4-enine + UDP-alpha-D-glucose <=> beta-D-glucosyl-L-erythro-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419389", "l": "LPA-binding receptors bind LPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45997", "l": "a D-alpha-amino acid + a quinone + H2O => a 2-oxocarboxylate + a quinol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112514", "l": "JAK activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917987", "l": "TFRC dimer binds 2xholoTF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63562", "l": "angiotensin II + L-histidyl-L-leucine => angiotensin I + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51746", "l": "a 1,2-diacyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63516", "l": "biphenyl-2,2',3-triol + H(+) + NADH + O2 = biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59773", "l": "D-sorbitol + O2 => D-sorbopyranose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953418", "l": "EHMT1:EHMT2 complex binds E2F6.com-1 core (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800315", "l": "MST1 binds MST1R (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047585", "l": "4-pyridoxolactonase activity", "d": ["Catalysis of the reaction: 4-pyridoxolactone + H2O = 4-pyridoxate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.10", "l": "\"dimethylglycine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624951", "l": "TNPO1 binds KIF17 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30640", "l": "(R)-glycerate + GDP-alpha-D-mannose => (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2214351", "l": "PLK1 phosphorylates GORASP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.14", "l": "\"procollagen N-endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16203", "l": "4-aminobenzoate + H(+) + pyruvate => 4-amino-4-deoxychorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661184", "l": "Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102622", "l": "linuron hydrolase activity", "d": ["Catalysis of the reaction: linuron + H2O = N,O-dimethylhydroxylamine + carbon dioxide + 3,4-dichloroaniline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18757", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 = CO2 + cylindrospermopsin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41797", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoylsphinganine => a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45261", "l": "tetracosanoate(out) => tetracosanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670428", "l": "KIT mutants bind GRB2-SOS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44734", "l": "(9Z,12Z)-octadecadienoate + glycerol + H(+) => 2-(9Z,12Z-octadecadienoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15161", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 = H2O + homogentisate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695949", "l": "SPHK2 phosphorylates sphingoid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20806", "l": "H(+) + hydrogencarbonate + NADH + propanoyl-CoA => 2-methyl-3-oxopropanoate + CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-186773", "l": "PDGF dimer binds two receptors simultaneously (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67864", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] = 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62960", "l": "7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35828", "l": "H2O + N(1)-(3-aminopropyl)agmatine => spermidine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48960", "l": "[thyroglobulin]-3-iodo-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850945", "l": "Casein kinase II phosphorylates PTEN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75865", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41503", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44126", "l": "CoA + tetradecanyl hexadecanoate => hexadecanoyl-CoA + tetradecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23058", "l": "cyanamide + H2O => urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626982", "l": "TNF-α:TNFR1:NSMAF binds GNB2L1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49632", "l": "(2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate = (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51906", "l": "10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate => 10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64776", "l": "3-sulfanylpentan-1-ol-L-cysteine = 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788867", "l": "FN3K phosphorylates ketosamines (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198669", "l": "p38MAPK phosphorylates MSK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114256", "l": "CYCS:APAF1 binds procaspase-9 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110215", "l": "Cleavage of uracil by UNG glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624956", "l": "PDE6D binds INPP5E (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008737", "l": "L-fuculokinase activity", "d": ["Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34986", "l": "sulfate(in) <=> sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001642", "l": "group III metabotropic glutamate receptor activity", "d": ["A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654409", "l": "Activated FGFR3 binds FRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37445", "l": "1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32848", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol => a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77081", "l": "Formation of the CE:GMP intermediate complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047615", "l": "actinomycin lactonase activity", "d": ["Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70708", "l": "6-sulfo-beta-D-quinovose => 6-sulfo-D-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.7.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31203", "l": "acetyl-CoA + hexanoyl-CoA = 3-oxooctanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40586", "l": "H2O + hexanedioyl-CoA <=> CoA + H(+) + hexanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45995", "l": "(3R)-3-hydroxydecanoyl-CoA <=> (2E)-decenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14511", "l": "3-epihydroxymugineate + CO2 + H(+) + succinate => 2-oxoglutarate + mugineate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748945", "l": "IMPDH tetramers dehydrogenate 6TIMP to 6TXMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380930", "l": "Phosphorylated AMPK binds AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660660", "l": "p300 acetylates RELA subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617179", "l": "PRKACA phosphorylates TNNI3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72089", "l": "2 Na(+)(in) + taurodeoxycholate(in) => 2 Na(+)(out) + taurodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "50.373041821489167", "identifiers": [{"i": "GO:0022890", "l": "inorganic cation transmembrane transporter activity", "d": ["Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209924", "l": "Dopa is decarboxylated to dopamine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65002", "l": "AMP + H(+) + octanoyl-[ACP] => holo-[ACP] + octanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.373103991056496", "identifiers": [{"i": "GO:0008170", "l": "N-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432909", "l": "Interaction of Plectin with Integrin beta 4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31420", "l": "(2Z,6E)-farnesyl diphosphate => (-)-beta-curcumene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33685", "l": "3-oxoeicosasphinganine + CO2 + CoA => H(+) + L-serine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015487", "l": "melibiose:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12072", "l": "an (S)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23015", "l": "a fatty acid + S-adenosyl-L-methionine <=> a fatty acid methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450533", "l": "PKCdelta phosphorylates HuR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3785684", "l": "Fibronectin degradation by CTSG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36767", "l": "2-hydroxytetracosenoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700179", "l": "Ligand-independent dimerization of ALK fusions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016689", "l": "manganese peroxidase activity", "d": ["Catalysis of the reaction: 2 Mn2+ + 2 H+ + hydrogen peroxide = 2 Mn3+ + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.9.-.-", "l": "\"Acting on phosphorus-nitrogen bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9702849", "l": "CALCR binds gepants (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828639", "l": "Transcription of respiratory syncytial virus subgenomic positive sense mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34385", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP => alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69480", "l": "an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.386", "l": "\"GlcNAc-beta-1,3-Gal beta-1,6-N-acetylglucosaminyltransferase (distally acting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33615", "l": "ATP + CoA + octadecanoate = AMP + diphosphate + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809663", "l": "Formation of hair keratin fibres (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64196", "l": "an N-(fatty acyl)-L-lysine + H2O = a fatty acid + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71093", "l": "dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in) => dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66652", "l": "(2E,6E)-farnesyl diphosphate = african-1-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53545", "l": "chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8876789", "l": "CARNMT1 methylates CARN to Anserine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31315", "l": "(2R)-3-phosphoglycerate + GDP-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28905", "l": "D-alanine(out) + H(+)(out) => D-alanine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33435", "l": "fecosterol = episterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17887", "l": "acetylene + H2O => acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.71648590403835", "identifiers": [{"i": "GO:0008186", "l": "ATP-dependent activity, acting on RNA", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24794", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45625", "l": "ATP + holo-[CmaA peptidyl-carrier protein] + L-alloisoleucine => AMP + diphosphate + L-alloisoleucyl-[CmaA peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659611", "l": "ANO1 inhibitors bind ANO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005462", "l": "UDP-N-acetylglucosamine transmembrane transporter activity", "d": ["Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71115", "l": "H(+) + hispidin + NADH + O2 = 3-hydroxyhispidin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418456", "l": "cGMP is degraded by PDEs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "64.614694807678219", "identifiers": [{"i": "GO:0043168", "l": "anion binding", "d": ["Binding to an anion, a charged atom or group of atoms with a net negative charge."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43246", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78152", "l": "a 3-acyl-sn-glycerol + H2O => a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30029", "l": "glycerol + NAD(+) => D-glyceraldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5658438", "l": "SPRED dimer binds NF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033775", "l": "deoxysarpagine hydroxylase activity", "d": ["Catalysis of the reaction: 10-deoxysarpagine + H+ + NADPH + O2 = H2O + NADP+ + sarpagine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50947", "l": "3-phenylpropanoate + NAD(+) <=> (E)-cinnamate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159005", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754775", "l": "SARS-CoV-2 M protein binds MAP1LC3B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51340", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012036", "l": "ME1 tetramer decarboxylates MAL to PYR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44386", "l": "1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16310", "l": "H2O + taurochenodeoxycholate => chenodeoxycholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640167", "l": "RRAGA,B exchanges GDP for GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11519", "l": "H2O + succinyl-CoA <=> CoA + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16222", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76329", "l": "L-aspartate(out) + L-phenylalanine(in) => L-aspartate(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63294", "l": "H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine => N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218642", "l": "PTK2 autophosphorylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63102", "l": "ascochlorin + 2 H2O + NADP(+) => H(+) + ilicicolin C + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943728", "l": "SALL4 binds the PTEN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63542", "l": "L-leucine + neurotensin-(1-12) => H2O + neurotensin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55362", "l": "9-cis-retinol => 11-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32632", "l": "erythromycin D + H(+) + NADPH + O2 => erythromycin C + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24537", "l": "L-tryptophan + O2 => N-formyl-L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56232", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O = [(1->4)-alpha-D-galacturonosyl](n-2) + alpha-D-galacturonosyl-(1->4)-D-galacturonate", "d": [], "t": []}, {"i": "EC:3.2.1.82", "l": "\"exo-poly-alpha-digalacturonosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45067", "l": "H2O + N-hexadecanoylethanolamine <=> ethanolamine + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266303", "l": "Spherical HDL binds C and E apolipoproteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676168", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419049", "l": "ROCK activation by RHO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103015", "l": "4-amino-4-deoxy-L-arabinose transferase activity", "d": ["Catalysis of the reaction: (Kdo)2-lipid A + 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate = (beta-L-Ara4N)2-(KDO)2-lipid A + 2 ditrans,polycis-undecaprenyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807053", "l": "SC5D desaturates LTHSOL to 7-dehydroCHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015275", "l": "stretch-activated, monoatomic cation-selective, calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617445", "l": "HOXD1 chromatin is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47768", "l": "guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35052", "l": "N,N'-diacetylchitobiose(out) => N,N'-diacetylchitobiose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869580", "l": "DEK binds TFAP2A homodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54934", "l": "(2E,9Z)-hexadecadienoyl-[ACP] + H2O => (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38201", "l": "19-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110354", "l": "Displacement of OGG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371527", "l": "HSF1 trimer translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57550", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44469", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol => a 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56692", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 4-[(E)-2-isocyanoethenyl]phenol + 2 CO2 + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.10", "l": "\"tyrosine isonitrile desaturase/decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875443", "l": "USP8 deubiquitinates LRIG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375776", "l": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49738", "l": "CO2 + deoxyviolacein + 2 H2O + NAD(+) => 2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928639", "l": "p-EFNB binds GRB4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247847", "l": "WLS is endocytosed to the early endosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983158", "l": "Trimming of peptides in ER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59298", "l": "an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical => an N-acylglycine + 2 L-ascorbate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762345", "l": "PREDN:ALB dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22949", "l": "D-tagatofuranose 1,6-bisphosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57664", "l": "(+)-valencene + O2 + reduced [NADPH--hemoprotein reductase] = alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61439", "l": "ADP + H2O <=> AMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018752", "l": "epsilon-caprolactam lactamase activity", "d": ["Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31866", "l": "(S)-2,3-epoxysqualene <=> friedelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102725", "l": "24-methyldesmosterol reductase activity", "d": ["Catalysis of the reaction: H+ + 24-methyldesmosterol + NADPH = campesterol + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24457", "l": "alpha-ribazole 5'-phosphate + H2O => alpha-ribazole + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69970", "l": "Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) <=> Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16458", "l": "(2R,3S)-tartrate + NAD(+) => 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34377", "l": "4-guanidinobutanoate + NH4(+) => 4-guanidinobutanamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59252", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate = (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28083", "l": "(2S)-ethylmalonyl-CoA + NADP(+) => (2E)-butenoyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8957241", "l": "TP73 tetramer translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22004", "l": "ATP + L-seryl-[myosin light chain] = ADP + H(+) + O-phospho-L-seryl-[myosin light chain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20000", "l": "H2O + phosphoenolpyruvate <=> phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.23.1.-", "l": "\"With NADH or NADPH as donor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43616", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.80", "l": "\"molybdopterin-synthase adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28296", "l": "(-)-(E)-beta-caryophyllene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68391", "l": "2 5,6-dihydroxyindole-2-carboxylate + O2 <=> 2 H2O + 2 indole-5,6-quinone-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24058", "l": "myo-inositol + phosphate => a myo-inositol phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58401", "l": "heptan-1-ol + NADP(+) => H(+) + heptanal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17979", "l": "a long-chain fatty acid + 3 H(+) + 2 NADH => a long-chain primary fatty alcohol + H2O + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77325", "l": "5-(3-methylguanidino)-2-oxopentanoate + glycine => glyoxylate + N(omega)-methyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69034", "l": "(2S)-2-nitrosobutanedioate + H2O => N,N-dihydroxy-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018758", "l": "RHOH binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.16", "l": "\"2',3'-cyclic-nucleotide 2'-phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218805", "l": "PKC autophosphorylates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50593", "l": "13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) => 15-oxoprostaglandin F1alpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38130", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193981", "l": "CYP21A2 oxidises 17HPROG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0070697", "l": "activin receptor binding", "d": ["Binding to an activin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015019", "l": "heparan-alpha-glucosaminide N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45642", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52692", "l": "3-phenyllactate + NADP(+) = 3-phenylpyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445700", "l": "Myosin Binds ATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-203979", "l": "Coat Assembly (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530445", "l": "CD59 inhibits MAC formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40984", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => (9Z)-octadecenoate + 1,3-dihexadecanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57308", "l": "CTP + H(+) + N(5)-phospho-L-glutamine = diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine", "d": [], "t": []}, {"i": "EC:2.7.7.103", "l": "\"L-glutamine-phosphate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21564", "l": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.16", "l": "\"acetyl-CoA C-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17033", "l": "(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) = biphenyl-2,3-diol + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.56", "l": "\"cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77484", "l": "heptan-2-one + hydrogen cyanide => (2S)-2-hydroxy-2-methylheptanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805205", "l": "GPR35 binds kynurenic acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17200", "l": "2 3-(4-hydroxyphenyl)pyruvate + O2 <=> 2 4-hydroxyphenylacetate + 2 CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426209", "l": "DAG activation of TRPC channels (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18585", "l": "D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.1", "l": "\"triose-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17500", "l": "formononetin + UDP-alpha-D-glucose <=> ononin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70510", "l": "LDH tetramer oxidises LACT to PYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47504", "l": "chenodeoxycholate + NADP(+) = 3-oxochenodeoxycholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011543", "l": "DCA binds PDK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22653", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63886", "l": "H2O + L-dopa => H2O2 + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9861616", "l": "DLD dimer dehydrogenates dihydrolipoyl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788611", "l": "HYKK phosphorylates 5HLYS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48992", "l": "1,3,7-trimethylurate + H(+) + NADH + O2 = 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.212", "l": "\"1,3,7-trimethyluric acid 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726875", "l": "HCNs:cAMP bind SNIs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.37", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39008", "l": "a cholesterol ester(in) => a cholesterol ester(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1022129", "l": "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44267", "l": "eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73382", "l": "(R)-lipoate(out) + 2 Na(+)(out) <=> (R)-lipoate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53181", "l": "D-erythrose => D-erythrulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796626", "l": "MIB2 ubiquitinates CFLAR  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69879", "l": "6alpha-hydroxycastasterone + O2 + reduced [NADPH--hemoprotein reductase] = castasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21716", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O", "d": [], "t": []}, {"i": "EC:1.14.16.6", "l": "\"mandelate 4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56671", "l": "7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20582", "l": "H2O + NAD(+) + NH4(+) => 2 H(+) + hydroxylamine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.8.-.-", "l": "\"Nitrogen-oxygen lyases\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32440", "l": "(+)-epi-isozizaene + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => albaflavenone + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.84", "l": "\"Ste24 endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.1", "l": "\"D-aspartate oxidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45662", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-419049", "l": "ROCK activation by RHO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72646", "l": "1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine <=> 1,6-dimethoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58081", "l": "1-docosanoylglycerol + H2O => docosanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73351", "l": "ATP + beta-alanine + histamine = AMP + carcinine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507869", "l": "Aquaporins passively transport glycerol into cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66119", "l": "2-oxobutanoate + L-glutamine <=> (2S)-2-aminobutanoate + 2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.69", "l": "\"8-oxo-(d)GTP phosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.115", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33478", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799329", "l": "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45074", "l": "(9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56844", "l": "nocamycin E + S-adenosyl-L-methionine = nocamycin I + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.351", "l": "\"nocamycin O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.15", "l": "\"endo-polygalacturonase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47035", "l": "AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA <=> 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25186", "l": "1,2-dichloroethane + H2O => 2-chloroethanol + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19696", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) <=> 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61022", "l": "5'-deoxyadenosine + 5-(carboxymethyl)uridine(34) in tRNA + CoA + 2 H(+) + L-methionine => acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56577", "l": "a globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine => a globoside Gb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684234", "l": "Encapsidation of SARS coronavirus genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379992", "l": "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018695", "l": "4-cresol dehydrogenase (hydroxylating) activity", "d": ["Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8960973", "l": "RLBP1:11cRAL dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51349", "l": "acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine => 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69346", "l": "(Z)-butanethial oxide => (E)-but-1-en-1-SO-peroxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56614", "l": "H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] => L-cysteinyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36322", "l": "2 H(+) + 2 NADPH + octadecanoyl-CoA <=> CoA + 2 NADP(+) + octadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60360", "l": "FMN + H(+) + oxidized coenzyme F420-0 = dehydro coenzyme F420-0 + FMNH2", "d": [], "t": []}, {"i": "EC:1.3.8.17", "l": "\"dehydro coenzyme F420 reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5632677", "l": "PTCH is internalized (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803892", "l": "SFN dimer binds BAX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60221", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674140", "l": "PAQR3 binds inactive RAFs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62416", "l": "(E)-4-coumaroyl-CoA + H2O = 4-hydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395764", "l": "atREs binds to nascent CM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110319", "l": "Elongation by POLH (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57094", "l": "A + glutathione + methanethiol => AH2 + S-(methylsulfanyl)glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62409", "l": "3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine => 1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58149", "l": "ethyl acetate + H2O => acetate + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39495", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47263", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62596", "l": "(S)-8-oxocitronellyl enol + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55850", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46020", "l": "[pyruvate, water dikinase] + ADP = [pyruvate, water dikinase]-phosphate + AMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.11.33", "l": "\"[pyruvate, water dikinase] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53715", "l": "2 Fe(III)-heme b <=> beta-hematin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683792", "l": "p-T68-CHEK2 autophosphorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.366", "l": "\"L-idonate 5-dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78300", "l": "guanosine(34) in tRNA(Tyr) + queuine => guanine + queuosine(34) in tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16614", "l": "acetyl-CoA + an arylamine => an N-acetylarylamine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9692129", "l": "Expression of PTGDS in testis differentiation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28584", "l": "ADP + dUTP => ATP + dUDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12977", "l": "H2O + N-phosphocreatine = creatine + phosphate", "d": [], "t": []}, {"i": "EC:3.9.1.1", "l": "\"phosphoamidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72230", "l": "chloride(out) + 2 Na(+)(out) + sarcosine(out) <=> chloride(in) + 2 Na(+)(in) + sarcosine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668415", "l": "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987141", "l": "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051408", "l": "glyceraldehyde 3-phosphate:phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61716", "l": "ATP + D-galactofuranose(out) + H2O = ADP + D-galactofuranose(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.5.2.9", "l": "\"ABC-type D-galactofuranose transporter\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682690", "l": "ATG10 dissociates from ATG12:ATG5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70241", "l": "PCK1 phosphorylates OA to yield PEP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40841", "l": "(2E)-nonenoyl-CoA + FADH2 => FAD + H(+) + nonanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28249", "l": "(R)-pantoate + ATP <=> (R)-4-phosphopantoate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56390", "l": "(4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48404", "l": "apo-[aryl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.99", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73119", "l": "kaempferol + S-adenosyl-L-methionine = H(+) + kaempferol 7-methyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198621", "l": "AKT phosphorylates caspase-9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72355", "l": "dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70456", "l": "(6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59335", "l": "1'-hydroxy-gamma-carotene + A <=> 1'-hydroxytorulene + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033414", "l": "UGC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGC codon."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11486", "l": "a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out) => a quinol + 2 Fe(III)-[cytochrome c](out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18215", "l": "CDP-D-glucose + diphosphate => alpha-D-glucose 1-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64879", "l": "H2O + UDP <=> H(+) + phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21326", "l": "H2O2 + oxidized [rubredoxin] => 2 H(+) + reduced [rubredoxin] + superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5323526", "l": "FRAT proteins bind GSK3beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106615", "l": "Removal of siRNA passenger strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56999", "l": "aldehydo-D-apiose <=> apulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14826", "l": "(1R,5S)-carveol + NAD(+) => (S)-carvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27503", "l": "3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine => 3',5'-di-O-methyltricetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45318", "l": "11beta-prostaglandin F2 + NADP(+) => H(+) + NADPH + prostaglandin D2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635996", "l": "NEIL3 resolves psoralen-induced ICLs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879674", "l": "CD97 binds CD55 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58605", "l": "FAD + 2 H(+) + NADH + O2 => FADH2-C4alpha-hydroperoxide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798374", "l": "DYRK2 phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045015", "l": "HDEL sequence binding", "d": ["Binding to a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11669", "l": "[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O => [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809680", "l": "MTMR12 binds MTM1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70372", "l": "3-oxosphinganine + decanoyl-CoA => CoA + H(+) + N-decanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649742", "l": "Defective SLC33A1 does not transport Ac-CoA from cytosol to Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445076", "l": "Phosphorylation of Y1229 in L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71408", "l": "7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] => 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76794", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 9-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15150", "l": "O2 + pyridoxine 5'-phosphate => H2O2 + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392530", "l": "p-S400-Cot phosphorylates NIK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28563", "l": "D-alanine + pyridoxal 5'-phosphate => pyridoxamine 5'-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14996", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51138", "l": "(10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61458", "l": "(1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+) => 7-chlorotetracycline + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54772", "l": "ATP + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide = 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25062", "l": "3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65053", "l": "4-(trifluoromethyl)benzyl alcohol + NAD(+) => 4-(trifluoromethyl)benzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55642", "l": "AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+) => C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008767", "l": "UDP-galactopyranose mutase activity", "d": ["Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66701", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48995", "l": "1,3,7-trimethylurate + H(+) + NADH + O2 <=> 1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49945", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate => (1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24240", "l": "A + AMP + 2 H(+) + sulfite = adenosine 5'-phosphosulfate + AH2", "d": [], "t": []}, {"i": "EC:1.8.99.2", "l": "\"adenylyl-sulfate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9856718", "l": "HPDL dioxygenates HPPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57231", "l": "GDP + glyoxal <=> N(2)-(1-hydroxy-2-oxoethyl)-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052758", "l": "coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity", "d": ["Catalysis of the reaction: 2,4,6-trinitrophenol + H- = 2,4,6-trinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36451", "l": "ATP + glycyl-L-glutamate(out) + H2O = ADP + glycyl-L-glutamate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75579", "l": "A + cyathatriol = AH2 + cyathin A3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24707", "l": "(6R)-10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinose => (6S)-5,6,7,8-tetrahydrofolate + H(+) + UDP-4-deoxy-4-formamido-beta-L-arabinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61104", "l": "(2S)-naringenin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (2S)-dihydrotricetin + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63487", "l": "2-oxoglutarate + L-prolyl-[protein] + O2 <=> CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39796", "l": "7beta-hydroxycholesterol(in) + ATP + H2O => 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112037", "l": "Inactivation of PLC beta (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71003", "l": "L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52224", "l": "3 AH2 + 3 H(+) + heme b + 3 O2 = 3 A + biliverdin IXdelta + CO + Fe(2+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42183", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67514", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202174", "l": "Activation of ZAP-70 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696997", "l": "USP24 deubiquitinates DDB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24214", "l": "4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) => 5-(2-hydroxyethyl)-4-methylthiazole + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34483", "l": "4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA = 4-hydroxybenzalacetone + 2 CO2 + 2 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.212", "l": "\"benzalacetone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38649", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+) => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446185", "l": "Isomerization of GlcNAc6P to GlcNAc1P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72025", "l": "nicotinate(out) + urate(in) => nicotinate(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853429", "l": "PHLDA1 binds AURKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0120016", "l": "sphingolipid transfer activity", "d": ["Removes a sphingolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353435", "l": "Elongation by Pol eta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.507798223252038", "identifiers": [{"i": "GO:0016620", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682983", "l": "ATM phosphorylates WHSC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46769", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13764", "l": "L-methionine + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + S-methyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70082", "l": "2-oxoglutarate + clavatol + O2 <=> CO2 + hydroxyclavatol + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174739", "l": "chylomicron remnant + apoE => chylomicron remnant:apoE complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56262", "l": "4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.120", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5444523", "l": "Formation of MSH1:PMS2 Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13269", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.45", "l": "\"glucosylceramidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24690", "l": "acetate + eugenol + NADP(+) = (E)-coniferyl acetate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34387", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13816", "l": "benzene + H(+) + NADH + O2 <=> cis-1,2-dihydrobenzene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15081", "l": "acetate + ATP + CoA = acetyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67464", "l": "H2O + propanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612277", "l": "SPARC gene transcription is stimulated by ERBB4s80 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11509", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 => 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71141", "l": "3 A + 10 CO2 + 11 CoA + cordypyrone A + 8 H2O + 8 NADP(+) => acetyl-CoA + 3 AH2 + 18 H(+) + 10 malonyl-CoA + 8 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17807", "l": "adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine => H2O + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76774", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,3-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47798", "l": "an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin] => an aralkylamine + H2O + 2 oxidized [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.5", "l": "\"3-oxoacid CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28040", "l": "[thioredoxin]-dithiol + CDP => [thioredoxin]-disulfide + dCDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52239", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + Fe(2+) + 3 H2O + mycobilin b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75019", "l": "1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate = 2,3-di-(10Z-heptadecenoyl)-sn-glycerol + 9-(10Z-heptadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.107701041804759", "identifiers": [{"i": "GO:0016866", "l": "intramolecular transferase activity", "d": ["Catalysis of the transfer of a functional group from one position to another within a single molecule."], "t": []}, {"i": "EC:5.4.-.-", "l": "\"Intramolecular transferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19330", "l": "nuatigenin + UDP-alpha-D-glucose => H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58566", "l": "15alpha-stemmadenine intermediate II + 2 H(+) + NADPH => 15alpha-stemmadenine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52694", "l": "3-phenylpyruvate + H(+) + NADPH => 3-phenyllactate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5444523", "l": "Formation of MSH1:PMS2 Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52812", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42900", "l": "guanosine(745) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.187", "l": "\"23S rRNA (guanine(745)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64721", "l": "H(+)(out) + pyruvate(out) => H(+)(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30452", "l": "(S)-2,3-epoxysqualene => isomultiflorenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10259", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O <=> [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60822", "l": "adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide => H2O + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62512", "l": "2-oxoglutarate + melatonin + O2 = 2-hydroxymelatonin + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2564824", "l": "NADPH reduces NDOR1:CIAPIN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336182", "l": "GPR37 binds prosaptide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696482", "l": "CTF1 binds LIFR:JAKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202960", "l": "Caspase mediated cleavage of C-IAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69788", "l": "(2-aminophenyl)succinate + succinyl-CoA => 3-(2-aminophenyl)succinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29587", "l": "4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.312", "l": "\"2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78613", "l": "15,20-dihydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68640", "l": "(2E)-geranyl diphosphate = diphosphate + limonene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41485", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73924", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine => griseophenone D + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40867", "l": "(9E)-octadecenoyl-CoA + FAD + H(+) = (2E,9E)-octadecadienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372529", "l": "Release of acetylcholine at the synapse (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19976", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + S-methyl-5'-thioadenosine + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10580", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42163", "l": "(11Z,14Z)-eicosadienoyl-CoA + AH2 + O2 <=> (5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102859", "l": "1-18:1-2-18:2-phosphatidylcholine desaturase activity (SN2-18:3 forming)", "d": ["Catalysis of the reaction: 1-18:1-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:1-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22119", "l": "luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769393", "l": "YWHAZ binds p-CBY:CTNNB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73207", "l": "sulfate(out) + sulfite(in) = sulfate(in) + sulfite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198983", "l": "NKG2D homodimer interacting with ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870269", "l": "Gastrin binds to CCK-B receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630921", "l": "NFKBIA variant binds NFkB complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754964", "l": "ADA deamidates RBV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16699", "l": "AH2 + kynurenate => A + H2O + quinaldate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382055", "l": "Grb7 binds to the active PDGF receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.18", "l": "\"glutathione transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031894", "l": "V1A vasopressin receptor binding", "d": ["Binding to a V1A vasopressin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825845", "l": "MITF-M dimer binds the TBX2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818937", "l": "MEN1 binds MLL1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71836", "l": "estrone 3-sulfate(out) => estrone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034938", "l": "pyrrole-2-carboxylate monooxygenase activity", "d": ["Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13454", "l": "3'-phosphoadenylyl sulfate + quercetin => adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14271", "l": "2 a 1,4-benzosemiquinone + NADP(+) => 2 a quinone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12063", "l": "acetyl-CoA + 5 H(+) + 6 malonyl-CoA <=> 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25520", "l": "an acyl-CoA + pseudotropine = CoA + H(+) + O-acylpseudotropine", "d": [], "t": []}, {"i": "EC:2.3.1.186", "l": "\"pseudotropine acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49153", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine => dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811412", "l": "Active ARF recruits coatomer to the Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660816", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33480", "l": "an acyl-CoA + lanosterol => CoA + lanosteryl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9669854", "l": "KIT binds type II TKIs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854052", "l": "Formation of the SCF-FBXL7 complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451377", "l": "Interaction of IQGAP1 with nephrin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29669", "l": "H2O(out) => H2O(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47106", "l": "5,6,7,8-tetrahydromethanopterin + L-serine => 5,10-methylenetetrahydromethanopterin + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9674093", "l": "PDGFRs bind type I TKI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38313", "l": "daunorubicin + H(+) + S-adenosyl-L-homocysteine => carminomycin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68600", "l": "(2S)-3-sulfopropanediol = 3-oxopropane-1-sulfonate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.177", "l": "\"(2S)-3-sulfopropanediol dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16534", "l": "L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27817", "l": "acetate(in) + Na(+)(in) <=> acetate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36680", "l": "dTDP-6-deoxy-alpha-D-allose + NAD(+) => dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61601", "l": "[DsbD protein]-disulfide + [protein]-dithiol => [DsbB protein]-dithiol + [protein]-disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0120300", "l": "peptide lactyltransferase (CoA-dependent) activity", "d": ["Catalysis of the reaction: (L-lysyl-[protein] + lactoyl-CoA = CoA + H+ + N(6)-lactoyl-L-lysyl-[protein]."], "t": []}, {"i": "RHEA:61996", "l": "L-lysyl-[protein] + lactoyl-CoA = CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109338", "l": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9620103", "l": "ALDH2 transforms GTN to NO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791108", "l": "Expression of SULT1A3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.48", "l": "\"15-oxoprostaglandin 13-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592316", "l": "Initial activation of proMMP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72935", "l": "(S)-lactate(out) + 2 Na(+)(out) = (S)-lactate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202731", "l": "JAM3 dimerises (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.154", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40529", "l": "2 a ubiquinone + 4 H(+)(out) + 2 H2O(in) => 2 a ubiquinol + 4 H(+)(in) + O2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805061", "l": "CK2 binds FACT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17836", "l": "3-hydroxyanthranilate + S-adenosyl-L-methionine <=> 3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59388", "l": "a fatty acid ester + H2O = a fatty acid + an aliphatic alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53798", "l": "deoxycholate + ursodeoxycholoyl-CoA => deoxycholoyl-CoA + ursodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37059", "l": "adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA", "d": [], "t": []}, {"i": "EC:2.3.1.234", "l": "\"N(6)-L-threonylcarbamoyladenine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39931", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570528", "l": "SUMOylation of XPC with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72679", "l": "(R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein] = AMP + diphosphate + H(+) + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964280", "l": "Active Gq binds BTK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54336", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665412", "l": "ERBB2 ECD mutants bind TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46503", "l": "2-oxoglutarate + O2 + UMP <=> CO2 + phosphate + succinate + uridine-5'-aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879937", "l": "The common beta chain IL3RB binds JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30270", "l": "2 monodehydro-L-ascorbate radical <=> L-ascorbate + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70480", "l": "H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) => 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33644", "l": "(9Z)-tetradecenoate + ATP + CoA => (9Z)-tetradecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71915", "l": "2 Na(+)(out) + tauronorcholate(out) = 2 Na(+)(in) + tauronorcholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655824", "l": "Expression of Farnesyl Diphosphate Synthase (FDPS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0031821", "l": "G protein-coupled serotonin receptor binding", "d": ["Binding to a metabotropic serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28101", "l": "ATP + GDP <=> AMP + guanosine 3',5'-bis(diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9844006", "l": "SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59173", "l": "hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] => AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9854415", "l": "ACAT1 tetramer acetylates IDH2 dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73332", "l": "(2R,3S)-piscidate + (E)-feruloyl-CoA => cimicifugate E + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28408", "l": "H(+) + phosphate + XDP => H2O + XTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31055", "l": "estrone 3-sulfate + H2O = estrone + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000327", "l": "PLK1 phosphorylates BORA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805109", "l": "CDK2 phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865276", "l": "PDGF-AB clevage by Furin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670433", "l": "KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205289", "l": "Autophosphorylation of KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78559", "l": "(3S)-hydroxytetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65191", "l": "2-oxoglutarate + berkeleyone B + O2 <=> berkeleydione + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68213", "l": "(9Z)-octadecenoyl-CoA + 1,2-dihexanoylglycerol => 1,2-dihexanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848370", "l": "IL18 binds IL18R1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9664867", "l": "NBR1 binds MAP1LC3B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019948", "l": "SUMO activating enzyme activity", "d": ["Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40632", "l": "H2O + trioctadecanoylglycerol => 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5622129", "l": "FABP5 binds atRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70366", "l": "cyanurate + H2O <=> 1-carboxybiuret + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9823904", "l": "TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602473", "l": "Autocatalytic activation of MMP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015134", "l": "hexuronate transmembrane transporter activity", "d": ["Enables the transfer of hexuronates from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76338", "l": "L-aspartate(in) + L-tryptophan(out) <=> L-aspartate(out) + L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061628", "l": "H3K27me3 modified histone binding", "d": ["Binding to a histone H3 in which the lysine residue at position 27 has been modified by trimethylation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63073", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 4 CO2 + 4 CoA + orcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73557", "l": "(E,E)-piperate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E,E)-feruperate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710354", "l": "GSDME (1-270) binds cardiolipin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75950", "l": "L-arginine + taurine <=> L-ornithine + taurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691154", "l": "HFE binds TFRC dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-398184", "l": "LARG activation by G alpha 12/13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40291", "l": "ATP + CoA + tetradecanedioate = AMP + diphosphate + tetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198669", "l": "p38MAPK phosphorylates MSK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49385", "l": "(12R)-hydroxy-(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => (12R),18-dihydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4086410", "l": "CDK1 phosphorylates BORA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099521", "l": "ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential", "d": ["Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61932", "l": "(S)-miconazole(in) + ATP + H2O = (S)-miconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005369", "l": "taurine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371582", "l": "HSBP1 binds HSF1 trimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0000906", "l": "6,7-dimethyl-8-ribityllumazine synthase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0003933", "l": "GTP cyclohydrolase activity", "d": ["Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102275", "l": "cysteine-S-conjugate N-malonyl transferase activity", "d": ["Catalysis of the reaction: malonyl-CoA(5-) + an L-cysteine-S-conjugate = coenzyme A + H+ + an N-malonyl-L-cysteine-S-conjugate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140537", "l": "transcription regulator activator activity", "d": ["A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41388", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38309", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018794", "l": "RHOV binds effectors at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5444516", "l": "Formation of MSH2:MSH6 Complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78772", "l": "3''-dehydroisoorientin => 1,5-anhydro-D-erythro-hex-1-en-3-ulose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37321", "l": "ADP + glycyl-L-methionine(in) + H(+) + phosphate => ATP + glycyl-L-methionine(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65483", "l": "2-methylbutanoyl-CoA + hexan-1-ol <=> CoA + hexyl 2-methylbutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030109", "l": "HLA-B specific inhibitory MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60117", "l": "2-oxoglutarate + methylphosphonate + O2 => CO2 + hydroxymethylphosphonate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16539", "l": "(9S,10S)-9,10-dihydroxyoctadecanoate + phosphate => (9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61748", "l": "rubusoside + UDP-alpha-D-glucose = H(+) + stevioside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20858", "l": "a fatty acid + sphing-4-enine => an N-acylsphing-4-enine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69173", "l": "Joining of adjacent Okazaki fragments (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5665871", "l": "ADRM1 binds 26S proteasome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465926", "l": "An atROL isomerase isomerises atROL to 11cROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008670", "l": "2,4-dienoyl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63923", "l": "octadecanoyl-CoA + sphinga-4E,14Z-dienine <=> CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53008", "l": "(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = di-trans,poly-cis-polyprenyl diphosphate + n diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.87", "l": "\"ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56790", "l": "cob(II)alamin-[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)alamin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55726", "l": "17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10752", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate", "d": [], "t": []}, {"i": "EC:6.3.1.12", "l": "\"D-aspartate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374683", "l": "Interaction of L1 with Neurocan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20436", "l": "NAD(+) + xylitol <=> D-xylulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193789", "l": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74947", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + 2-oxoglutarate + O2 = (3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112271", "l": "The receptor:G-protein complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73596", "l": "dCMP + H2O => dUMP + NH4+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11255", "l": "H(+) + hydroxylamine + L-asparagine <=> beta-L-aspartylhydroxamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692785", "l": "p-S215 FOXO1 binds RAG gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211960", "l": "CYP2U1 19-hydroxylates ARA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77615", "l": "(9Z)-octadecenoyl-CoA + 1-decanoylglycerol = 1-decanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444572", "l": "Zinc is an agonist of GPR39 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10031", "l": "D-glutamate + H2O + O2 <=> 2-oxoglutarate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56657", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047704", "l": "bile-salt sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012268", "l": "ME2 tetramer decarboxylates MAL to PYR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983421", "l": "Journey of cargo through Golgi complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58488", "l": "4-(trimethylamino)butanoate + H(+) + NADH + O2 = H2O + NAD(+) + succinate semialdehyde + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59734", "l": "AMP + 2 H(+) + N(6)-biotinyl-L-lysyl-[protein] => biotinyl-5'-AMP + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71039", "l": "L-methionine(in) + L-phenylalanine(out) = L-methionine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52562", "l": "3-dehydro-D-erythronate => 2-dehydro-D-erythronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429581", "l": "SLC5A6 transports vitamins from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30355", "l": "a quinol + methane + O2 = a quinone + H2O + methanol", "d": [], "t": []}, {"i": "EC:1.14.18.3", "l": "\"methane monooxygenase (particulate)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23016", "l": "(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) = (2R,3R)-dihydrokaempferol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53629", "l": "(2E,6E)-farnesyl diphosphate => (2S,3R,6S,9S)-(-)-protoillud-7-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38124", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol => 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18802", "l": "(cis-prenyl)n-diphosphate + isopentenyl diphosphate => (cis-prenyl)(n+1)-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49137", "l": "H(+) + L-methionyl-[protein] + NADPH + O2 => H2O + L-methionyl-S-oxide-[protein] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53935", "l": "O2 + prostaglandin I2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-prostaglandin I2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55761", "l": "a fatty acyl-[ACP] + a lyso-ornithine lipid => an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.507798223252038", "identifiers": [{"i": "GO:0015293", "l": "symporter activity", "d": ["Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49146", "l": "dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78509", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016015", "l": "morphogen activity", "d": ["Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28089", "l": "2 H2O2 + Reactive Blue 5 <=> 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24328", "l": "7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.17", "l": "\"formate--dihydrofolate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28360", "l": "(2E)-tetradecenoyl-CoA + FADH2 => FAD + H(+) + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047499", "l": "calcium-independent phospholipase A2 activity", "d": ["Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+."], "t": []}, {"i": "REACT:R-HSA-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19202", "l": "2'-deoxyguanosine + ATP => ADP + dGMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14770", "l": "(S)-nicotine + A + H2O => (S)-6-hydroxynicotine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20351", "l": "2-hydroxytoluene + H2O + NAD(+) => H(+) + NADH + O2 + toluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8856223", "l": "B4GALNT1 dimer transfers GalNAc to gangliosides (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.48", "l": "\"plasminogen activator Pla\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23769", "l": "a fatty acyl-CoA + sphing-4-enine => an N-acylsphing-4-enine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40139", "l": "(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57303", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O <=> a 2'-deoxyguanosine in DNA + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112385", "l": "Addition of nucleotides leads to transcript elongation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69392", "l": "an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64568", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one = ilicicolin H", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2160931", "l": "Disassembly of tight junctions (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56840", "l": "5-amino-2-hydroxybenzoate + O2 = (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.86", "l": "\"5-aminosalicylate 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31554", "l": "presqualene diphosphate <=> 15-cis-4,4'-diapophytoene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5220959", "l": "TDG excises 5-formylcytosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199456", "l": "PTEN dephosphorylates PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012036", "l": "ME1 tetramer decarboxylates MAL to PYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35852", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866304", "l": "pre-VLDL binds lipids to form VLDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805507", "l": "APAF1 binds AVEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710468", "l": "GSDME variant does not bind PIPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50057", "l": "ATP + glycocholate(in) + H2O => ADP + glycocholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71625", "l": "malonate(in) + phosphate(out) => malonate(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34587", "l": "2-oxoglutarate + O2 + pentalenolactone E = CO2 + pentalenolactone F + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69363", "l": "bromide + H(+) + H2O2 + L-tyrosyl-[protein] <=> 3-bromo-L-tyrosyl-[protein] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17148", "l": "2'-hydroxy-2,3-dihydrodaidzein + NADP(+) <=> 2'-hydroxydaidzein + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166387", "l": "The FA anion diffuses away laterally from UCP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033951", "l": "oligosaccharide reducing-end xylanase activity", "d": ["Catalysis of the hydrolysis of 1,4-beta-D-xylose residues from the reducing end of oligosaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10771", "l": "(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 <=> (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801776", "l": "REG3A binds bacterial phospholipids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58212", "l": "ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] = dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48717", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 13-oxo-(9Z,11E)-octadecadienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58162", "l": "diphosphate + dolabradiene => ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164840", "l": "ADP and Pi bind to ATPase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45540", "l": "H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106614", "l": "Duplex miRNA is loaded into Argonaute (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6804100", "l": "HMGB1 binds LPS (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42349", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42906", "l": "H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(748) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56787", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O <=> (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39471", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-179410", "l": "Association of Nek2A with MCC:APC/C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33695", "l": "C20 sphinganine + NADP(+) = 3-oxoeicosasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38428", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18848", "l": "(R)-glycerate + NAD(+) <=> 2-hydroxy-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18397", "l": "ATP + L-glutamate + tRNA(Glx) = AMP + diphosphate + L-glutamyl-tRNA(Glx)", "d": [], "t": []}, {"i": "EC:6.1.1.24", "l": "\"glutamate--tRNA(Gln) ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59620", "l": "H2O + N(2)-(4-aminobutanoyl)-L-lysine = 4-aminobutanoate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65600", "l": "4,5,8-trihydroxycasbene + 2 NAD(+) = 2 H(+) + jolkinol C + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40474", "l": "(2S)-methylpentadecanoyl-CoA + O2 <=> 2-methyl-(2E)-pentadecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70899", "l": "histidine => urocanate + NH4+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40115", "l": "H2O + hexanoyl-CoA = CoA + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47824", "l": "H(+) + malonyl-[ACP] + octadecanoyl-[ACP] = 3-oxoeicosanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20095", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP => an anthocyanidin + H(+) + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692764", "l": "MAPK6 binds CCND3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174438", "l": "Formation of the Flap Intermediate on the C-strand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.59", "l": "\"protein geranylgeranyltransferase type I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34685", "l": "alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+) => alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788974", "l": "Hypochlorous acid and nitrite react to nitryl chloride (NO2Cl) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65336", "l": "chrodrimanin T + H(+) + NADPH + O2 = chrodrimanin A + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62522", "l": "an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59573", "l": "H2O + L-homocarnosine => 4-aminobutanoate + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043715", "l": "2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity", "d": ["Catalysis of the reaction: 2,3-diketo-5-methylthiopentyl-1-phosphate = H+ + 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate. 2,3-diketo-5-methylthiopentyl-1-phosphate is also known as DK-MTP-1-P, and 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate as HK-MTPenyl-1-P."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160003", "l": "mono-ADP-D-ribose modification-dependent protein binding", "d": ["Binding to a protein upon mono-ADP-ribosylation of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78666", "l": "gamma-lactone-2-keto[5.5.5.5]fenestrane + H(+) + NADPH + O2 <=> H2O + NADP(+) + penifulvin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004037", "l": "allantoicase activity", "d": ["Catalysis of the reaction: allantoate + H2O = (S)-ureidoglycolate + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734475", "l": "PPARA binds fibrates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43540", "l": "ATP + L-seryl-[isocitrate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[isocitrate dehydrogenase]", "d": [], "t": []}, {"i": "EC:2.7.11.5", "l": "\"[isocitrate dehydrogenase (NADP(+))] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2509827", "l": "ITPA hydrolyses ITP to IMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110215", "l": "Cleavage of uracil by UNG glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59954", "l": "2,6-dimethylheptanoate + CoA + H(+) => 2,6-dimethylheptanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035538", "l": "carbohydrate response element binding", "d": ["Binding to a carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49639", "l": "H2O + methylglyoxal + O2 <=> H(+) + H2O2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34505", "l": "(+)-epi-alpha-bisabolol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46621", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol => (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60705", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66858", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate => (2E)-geranyl diphosphate + 3 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40794", "l": "H2O + hexacosanoyl-CoA <=> CoA + H(+) + hexacosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700156", "l": "Active ALK dimer binds IRS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62436", "l": "L-lyxonate = 2-dehydro-3-deoxy-L-arabinonate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.176", "l": "\"L-lyxonate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45019", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-selenohomocysteine <=> L-selenomethionine + tetrahydropteroyltri-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448741", "l": "IL22RA2 binds IL22 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35723", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53944", "l": "2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) = (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59784", "l": "H2O + NADP(+) + pseudopaline = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27945", "l": "(3R)-3-hydroxy-D-aspartate <=> NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30947", "l": "(2E,6E)-farnesyl diphosphate + H2O = 10-epi-gamma-eudesmol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.84", "l": "\"10-epi-gamma-eudesmol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28512", "l": "beta-D-glucose 6-phosphate + hydroquinone => arbutin 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0030492", "l": "hemoglobin binding", "d": ["Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43764", "l": "ATP + chenodeoxycholate + CoA = AMP + chenodeoxycholoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047517", "l": "1,4-beta-D-xylan synthase activity", "d": ["Catalysis of the reaction: UDP-D-xylose + [(1->4)-beta-D-xylan](n) = UDP + [(1->4)-beta-D-xylan](n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928578", "l": "EPH receptors autophosphorylate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69220", "l": "a (Z)-glucosinolate + H2O = a (Z)-N-(sulfonatooxy)alkanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26301", "l": "5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.97", "l": "\"2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174171", "l": "Association of Cyclin A with the APC/C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62497", "l": "ATP + H(+) + L-arginine => diphosphate + L-arginyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692867", "l": "HRH3 binds pitosilant (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50295", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28357", "l": "decanoyl-CoA + FAD + H(+) <=> (2E)-decenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56557", "l": "(2E,6E)-farnesyl diphosphate => delta-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112385", "l": "Addition of nucleotides leads to transcript elongation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15414", "l": "(2R,3R)-tartrate => H2O + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49924", "l": "(R)-carnitine(out) + O-acyl-(R)-carnitine(in) = (R)-carnitine(in) + O-acyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56043", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) <=> beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-597628", "l": "SLC22A18 exchanges extracellular organic cations for cytosolic H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47898", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH => 6-sulfo-D-quinovose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191830", "l": "snRNP nuclear import and release (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866851", "l": "CFTR transits to the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450971", "l": "NNT dimer transfers proton from NADPH to NAD+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47343", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9859148", "l": "BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103039", "l": "protein methylthiotransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [ribosomal protein S12] L-aspartate89 + a sulfurated [sulfur carrier] + a reduced electron acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2 H+ + a [ribosomal protein S12] 3-methylthio-L-aspartate89 + an unsulfurated [sulfur carrier] + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028598", "l": "Phosphorylation of YAP by LATS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48316", "l": "a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68572", "l": "L-tyrosine(in) = L-tyrosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683792", "l": "p-T68-CHEK2 autophosphorylates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160129", "l": "protein-DNA covalent cross-linking activity", "d": ["Catalysis of the cross-link between a protein and a DNA abasic site, forming a thiazolidine linkage between a DNA ring-opened abasic site and the alpha-amino and sulfhydryl substituents of cysteine residue of the protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38399", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692764", "l": "MAPK6 binds CCND3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65939", "l": "beta-D-mannose <=> beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31390", "l": "(S)-2,3-epoxysqualene <=> alpha-amyrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23451", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP <=> CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74818", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69354", "l": "H2O + thiosulfinate => 2 (E)-prop-1-en-1-SO-peroxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19315", "l": "an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+) => an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47101", "l": "choloyl-CoA + taurine => CoA + H(+) + taurocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49943", "l": "(1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2 <=> (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38078", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25161", "l": "2-oxoglutarate + L-ornithine => L-glutamate + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77041", "l": "4-hydroxyhexan-3-one + H(+) + NADH + NH4(+) => 4-hydroxyhexan-3-amine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30892", "l": "O-acetyl-L-serine + thiosulfate => acetate + H(+) + S-sulfo-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.98", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70339", "l": "alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O = beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-847070", "l": "Phosphorylated TAK1 dissociates from the TLR3 receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937807", "l": "SRC phosphorylates RUNX3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28669", "l": "(S)-propane-1,2-diol + NAD(+) => H(+) + hydroxyacetone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42528", "l": "uridine(955/2504/2580) in 23S rRNA = pseudouridine(955/2504/2580) in 23S rRNA", "d": [], "t": []}, {"i": "EC:5.4.99.24", "l": "\"23S rRNA pseudouridine(955/2504/2580) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75932", "l": "H2O + taurocyamine => taurine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54382", "l": "5-hydroxy-alpha-gurjunene + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015648", "l": "lipid-linked peptidoglycan transporter activity", "d": ["Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44776", "l": "2-demethylmenaquinol-6 + S-adenosyl-L-methionine = H(+) + menaquinol-6 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49221", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP => CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13619", "l": "5-(methylsulfanyl)-D-ribose + adenine => H2O + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71245", "l": "chloride(in) + hypotaurine(in) + 2 Na(+)(in) => chloride(out) + hypotaurine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626816", "l": "PIN1 binds p-S345-NCF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33419", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.38", "l": "\"(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63140", "l": "H2O + N-tetracosanoyl-taurine = taurine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193068", "l": "CYP17A1 17-hydroxylates PREG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55922", "l": "(4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3) => [cis-1,4-isoprene](n) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008184", "l": "glycogen phosphorylase activity", "d": ["Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197963", "l": "DHFR2 reduces FOLA to DHF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10299", "l": "D-glyceraldehyde 3-phosphate + NADP(+) + phosphate <=> (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67638", "l": "dZMP + fumarate => (2S)-2-amino-2'-deoxyadenylo-succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694294", "l": "E pentamer is transported to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6805981", "l": "HMGB1 release from cells (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3257122", "l": "SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27918", "l": "H2O + NADP(+) + propanal = 2 H(+) + NADPH + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33065", "l": "NADH + 2 oxidized [2Fe-2S]-[putidaredoxin] => H(+) + NAD(+) + 2 reduced [2Fe-2S]-[putidaredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39019", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.95", "l": "\"phosphatidylinositol-3,5-bisphosphate 3-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37281", "l": "ADP + H(+) + L-alanyl-L-histidine(in) + phosphate => ATP + H2O + L-alanyl-L-histidine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69302", "l": "benzyl isothiocyanate + sulfate => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110231", "l": "Cleavage of uracil by MBD4 glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0005375", "l": "copper ion transmembrane transporter activity", "d": ["Enables the transfer of copper (Cu) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56604", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = 6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28818", "l": "4-hydroxybenzoate(in) + H(+)(out) <=> 4-hydroxybenzoate(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47637", "l": "H2O + L-arginine + NADP(+) => 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68615", "l": "Formation of ORC(1-6) complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9691621", "l": "C5 binds C5 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13601", "l": "cis-4-hydroxy-L-proline + NAD(+) = 4-oxo-L-proline + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.104", "l": "\"4-oxoproline reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14238", "l": "10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30574", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine <=> 6 AMP + 6 diphosphate + enterobactin + 4 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71741", "l": "2-oxoadipate(out) + 2-oxoglutarate(in) => 2-oxoadipate(in) + 2-oxoglutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13887", "l": "CO2 + stipitatate => H2O + stipitatonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29313", "l": "FMN + glyoxylate + 2 H(+) + H2O + sulfite => FMNH2 + O2 + sulfoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376122", "l": "DSCAM/DSCAML1 homodimerization (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9824994", "l": "RPS6KA1-dependent phosphorylation of MITF-M (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52663", "l": "an L-alpha-amino acid + ATP + holo-[ACP] <=> AMP + an L-alpha-aminoacyl-[ACP] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42721", "l": "S-adenosyl-L-methionine + uridine(2552) in 23S rRNA => 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156910", "l": "Formation of eEF1B complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354124", "l": "Phosphorylation of pPTK2 by SRC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-912734", "l": "CBL:CRKL binds RAPGEF1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69160", "l": "agmatine + H2O + O2 = H2O2 + N-amidino-(2R)-hydroxypyrrolidine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54933", "l": "(3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] => (2E,9Z)-hexadecadienoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13550", "l": "beta-L-fucose 1-phosphate + GTP + H(+) => diphosphate + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036970", "l": "NTRK3 activates RAS through SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428918", "l": "Dissociation of the TP:G13 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50756", "l": "NADP(+) + reduced [flavodoxin] = 2 H(+) + NADPH + oxidized [flavodoxin]", "d": [], "t": []}, {"i": "EC:1.19.1.1", "l": "\"flavodoxin--NADP(+) reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140842", "l": "n fibrin monomers -> fibrin multimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61247", "l": "H2O + L-tryptophan + O2 <=> H2O2 + indole-3-pyruvate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68485", "l": "(2R)-2-hydroperoxydodecanoate + H(+) => CO2 + H2O + undecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54449", "l": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O => a tRNA + an N-acyl-L-amino acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374699", "l": "UNC5A binds NRAGE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264435", "l": "Dissociation of the COP1-p53 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58547", "l": "2 L-ascorbate + N-tetradecanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55096", "l": "(3S)-3-hydroxypentanoyl-CoA + H2O = (3S)-3-hydroxypentanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63648", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69812", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.7", "l": "\"cyclic alcohol dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757256", "l": "MCM3 binds MCM5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010181", "l": "FMN binding", "d": ["Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64180", "l": "an N-(fatty acyl)-L-tryptophan + H2O = a fatty acid + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70997", "l": "SUCLG1/A2 cleaves succinyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69978", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793680", "l": "OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69181", "l": "ADP + thiamine diphosphate => AMP + thiamine triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0000179", "l": "rRNA (adenine-N6,N6-)-dimethyltransferase activity", "d": ["Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051061", "l": "ADP reductase activity", "d": ["Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791066", "l": "Expression of HYOU1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46918", "l": "H(+) + juvenile hormone I carboxylate + methanol => H2O + juvenile hormone I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33409", "l": "diphosphate + glycyl-5'-AMP => ATP + glycine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193700", "l": "p75NTR ICD signals to NF-kB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102394", "l": "4-hydroxy-L-isoleucine dehydrogenase activity", "d": ["Catalysis of the reaction: (2S,3R,4S)-4-hydroxy-L-isoleucine + NAD = (2S,3R)-2-amino-3-methyl-4-ketopentanoate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483219", "l": "PC is exchanged with PI by PITPNB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21805", "l": "ATP + myo-inositol => 1D-myo-inositol 3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19875", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate => dehydroepiandrosterone 3-sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371554", "l": "HSF1 acetylation at Lys80 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781814", "l": "USP19 deubiquitinates RNF123 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5225649", "l": "RBBP7 binds histone H3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9861631", "l": "ME1 tetramerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9823932", "l": "Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65815", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 <=> A + H2O + N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69500", "l": "L-arginyl-[protein] + NAD(+) = ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42100", "l": "ATP + carbamoyl phosphate + H2O + kanamycin A = 6''-O-carbamoylkanamycin A + AMP + diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61182", "l": "H(+) + quercetin 3-O-beta-D-glucoside + UDP => quercetin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45446", "l": "H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate => H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27339", "l": "15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin] => 2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72626", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-(2-hydroxy-fatty acyl)-dihydroceramide <=> a 1,2-diacyl-sn-glycerol + inositol-1-phospho-N-(2-hydroxy-fatty acyl)-dihydroceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917811", "l": "STEAP3,STEAP4 reduce Fe3+ to Fe2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75741", "l": "10-oxooctadecanoate + NAD(+) => 10-oxo-(11E)-octadecenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033719", "l": "2-oxo-acid reductase activity", "d": ["Catalysis of the reaction: a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68876", "l": "ATP + H(+) + NADPH + piperonylate = AMP + diphosphate + NADP(+) + piperonal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901149", "l": "salicylic acid binding", "d": ["Binding to salicylic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015107", "l": "chlorate transmembrane transporter activity", "d": ["Enables the transfer of chlorate, ClO3-, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2203480", "l": "COLEC11 binds ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51691", "l": "galactitol + NAD(+) <=> H(+) + keto-L-tagatose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72185", "l": "mRNA polyadenylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004995", "l": "tachykinin receptor activity", "d": ["Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50183", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209960", "l": "Diiodinated tyrosine can be deiodinated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51202", "l": "H2O + N-retinylidene-N-retinylphosphatidylethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57281", "l": "a guanosine in RNA + glyoxal => an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200646", "l": "Cytosolic folate export across the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70965", "l": "3-phenylpyruvate + H2O2 + NH4(+) => D-phenylalanine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58548", "l": "2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473594", "l": "Collagen type II degradation by MMP15 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983194", "l": "Kinesin-1 is a heterotetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016464", "l": "chloroplast protein-transporting ATPase activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49850", "l": "(-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+) => (-)-dehydrodiconiferyl acid ketone + a quinone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67958", "l": "(R)-lactate + chloride + H(+) => (S)-2-chloropropanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70997", "l": "SUCLG1/A2 cleaves succinyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784861", "l": "HSPG binds LPL dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47716", "l": "4-pregnen-20,21-diol-3-one + NAD(+) = 21-hydroxyprogesterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45058", "l": "H(+) + H2O + nogalonate => deoxynogalonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760122", "l": "AcK-NFE2L2-dependent GCLC gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75814", "l": "acetoacetate(out) + Na(+)(out) <=> acetoacetate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47127", "l": "glycine + hexacosanoate <=> H2O + N-hexacosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52678", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine => [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71020", "l": "L-phenylalanine(out) + L-valine(in) => L-phenylalanine(in) + L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32495", "l": "(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] = (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.83", "l": "\"geraniol 8-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9716947", "l": "ESR1 binds ESR1 agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932021", "l": "RUNX1 and ESR1 bind the GPAM gene enhancer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19124", "l": "an S-substituted glutathione(in) + ATP + H2O <=> ADP + an S-substituted glutathione(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50719", "l": "dimethyl sulfone + FMNH2 + O2 <=> FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13760", "l": "(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose <=> (Z)-desulfoglucotropeolin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68376", "l": "glyoxylate + L-asparagine = 2-oxosuccinamate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64683", "l": "benzoyl-CoA + ethanol <=> CoA + ethyl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76697", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3785768", "l": "MRN complex binds DNA double strand breaks (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40724", "l": "(9E)-octadecenoyl-CoA + H2O => (9E)-octadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38298", "l": "(R)-2-hydroxyglutarate + A <=> 2-oxoglutarate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24662", "l": "H2O + N(omega)-hydroxy-L-arginine + NADP(+) => H(+) + L-arginine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41290", "l": "H2O + N-tetradecanoylsphing-4-enine <=> sphing-4-enine + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45149", "l": "3-(methylsulfanyl)acryloyl-CoA + H2O => 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9825747", "l": "CREBBP acetylates HINT1 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102788", "l": "4-coumaroyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + pelargonidin 3-O-beta-D-glucoside = pelargonidin 3-O-beta-D-p-coumaroylglucoside + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102873", "l": "1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:0-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:0-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392749", "l": "Transport of L1 into endosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66423", "l": "ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49183", "l": "a bacteriochlorophyllide d + S-adenosyl-L-methionine <=> a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942075", "l": "Peroxynitrite and carbon dioxide react to nitrosoperoxycarbonate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77208", "l": "3'-phosphoadenylyl sulfate + glycodeoxycholate => 3alpha-sulfoglycodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990206", "l": "jasmonyl-Ile conjugate hydrolase activity", "d": ["Catalysis of the reaction: jasmonyl-Ile + H2O = jasmonic acid + L-isoleucine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989753", "l": "Expression of PEX11A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50575", "l": "acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2534240", "l": "HSPG2 (perlecan) degradation by MMP14, MMP15 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875816", "l": "STAT3 binds activated MET receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24025", "l": "(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate => (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14366", "l": "2 H(+) + H2O + N-carbamoyl-L-aspartate => CO2 + L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22924", "l": "dCMP + H(+) + H2O = dUMP + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.12", "l": "\"dCMP deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22640", "l": "NADP(+) + sphinganine = 3-oxosphinganine + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.102", "l": "\"3-dehydrosphinganine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73403", "l": "(2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9825783", "l": "p-S207 KARS1 dimer translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867047", "l": "PTPN3 dephosphorylates EPS15 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33056", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O => diphosphate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54989", "l": "4 e(-) + 4 H(+)(in) + O2(in) => 2 H2O(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052934", "l": "alcohol dehydrogenase (cytochrome c) activity", "d": ["Catalysis of the reaction: 2 [Fe(III)cytochrome c] + a primary alcohol = 2 [Fe(II)cytochrome c] + an aldehyde + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0003810", "l": "protein-glutamine gamma-glutamyltransferase activity", "d": ["Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141423", "l": "Binding of the MCC complex to the APC/C complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14668", "l": "guanine + H(+) + H2O <=> NH4(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24359", "l": "a 1-acyl-sn-glycero-3-phosphocholine <=> a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68032", "l": "(S)-cystathionine ketimine + 2 H(+) + NADH = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72180", "l": "Cleavage of mRNA at the 3'-end (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15309", "l": "(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.5", "l": "\"phycocyanobilin:ferredoxin oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.1", "l": "\"Physarum polycephalum ribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034547", "l": "N-cyclopropylmelamine deaminase activity", "d": ["Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19839", "l": "beta-D-fructose 6-phosphate + H(+) + NADH => D-sorbitol 6-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50041", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74723", "l": "Endosome acidification (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34172", "l": "L-aspartate 4-semialdehyde + pyruvate => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793591", "l": "LIAS synthesizes lipoyl-GCSH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55947", "l": "2-chloroethanol + 2 Fe(III)-[cytochrome c] <=> chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665809", "l": "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20773", "l": "2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) => 5-amino-6-(D-ribitylamino)uracil + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683455", "l": "nsp16 binds VHL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55184", "l": "2-oxoglutarate + 3-methylundecanoyl-CoA + O2 = 2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708430", "l": "XPO1 (CRM1) binds to BACH1:Hemes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49220", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP = CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.92", "l": "\"3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67159", "l": "1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55329", "l": "9-cis-retinol + hexadecanoyl-CoA => 9-cis-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341048", "l": "SUMOylation of RXRA with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26462", "l": "6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine = 3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15348", "l": "ATP + L-arginine + L-tyrosine <=> AMP + diphosphate + H(+) + L-tyrosyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6782943", "l": "UV-DDB ubiquitinates XPC (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25380", "l": "2-hydroxy-3-methylhexadecanoyl-CoA => 2-methylpentadecanal + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22543", "l": "5'-dehydroadenosine + H2O + O2 <=> 9-riburonosyladenine + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602484", "l": "Activation of proMMP11 by FURIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9728664", "l": "GLP1R binds GLP1R agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39583", "l": "(2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17505", "l": "H2O + N-(long-chain fatty acyl)ethanolamine = a long-chain fatty acid + ethanolamine", "d": [], "t": []}, {"i": "EC:3.5.1.60", "l": "\"N-(long-chain-acyl)ethanolamine deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69791", "l": "D-phenylalanyl-tRNA(Phe) + H2O = D-phenylalanine + H(+) + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18030", "l": "2 ATP + hydrogencarbonate + NH4(+) => 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49382", "l": "5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66926", "l": "[(R)-3-hydroxyalkanoate](n+1) + CoA => [(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372819", "l": "PCK2 phosphorylates OA to yield PEP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55903", "l": "chloride + FADH2 + L-tryptophan + O2 <=> 6-chloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35439", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine = archaetidylserine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047331", "l": "diphosphate-glycerol phosphotransferase activity", "d": ["Catalysis of the reaction: glycerol + diphosphate = glycerol 1-phosphate + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9861667", "l": "DLAT trimer transfers acetyl to CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0047267", "l": "undecaprenyl-phosphate mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-mannose + undecaprenyl phosphate = GDP + D-mannosyl-1-phosphoundecaprenol."], "t": []}, {"i": "EC:2.4.1.54", "l": "\"undecaprenyl-phosphate mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75966", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione <=> 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428696", "l": "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15334", "l": "(S)-ureidoglycolate + NADP(+) => H(+) + N-carbamoyl-2-oxoglycine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12202", "l": "CO2 + mugineate + succinate => 2'-deoxymugineate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005049", "l": "nuclear export signal receptor activity", "d": ["Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein."], "t": []}, {"i": "REACT:R-HSA-178215", "l": "SMAD7:SMURF1 complex is exported to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9029690", "l": "Caspase-6 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51428", "l": "acetyl-CoA + aminomethylphosphonate = 2-N-acetamidomethylphosphonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990594", "l": "L-altrarate dehydratase activity", "d": ["Catalysis of the reaction: L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O."], "t": []}, {"i": "RHEA:44028", "l": "L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.156", "l": "\"L-talarate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24191", "l": "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) <=> 1,2-dihydroxydibenzothiophene + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39203", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADPH = NADP(+) + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37267", "l": "H2O + L-alanyl-L-aspartate = L-alanine + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106276", "l": "biliberdin reductase NAD+ activity", "d": ["Catalysis of the reaction: bilirubin + NAD+ = biliverdin + NADH+ H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28506", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP = 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71440", "l": "L-dopa(out) + L-phenylalanine(in) => L-dopa(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9854315", "l": "CSKMT methylates Citrate Synthase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299657", "l": "Defective TCII does not bind Cbl in the circulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33189", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35602", "l": "NADP(+) + propane-1,3-diol <=> 3-hydroxypropanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59661", "l": "D-cellotetraose + O2 => D-cellotetraono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008480", "l": "sarcosine dehydrogenase activity", "d": ["Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399712", "l": "Activation of Ca permeable AMPA receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14089", "l": "2-oxoglutarate + glycine = glyoxylate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.4", "l": "\"glycine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51486", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2152276", "l": "Secretion of transmembrane collagens (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909738", "l": "SHP1 and SHP2 bind the common beta chain (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14172", "l": "ATP + CoA + glutarate <=> ADP + glutaryl-CoA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17057", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.141", "l": "\"galactosylacylglycerol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29010", "l": "H(+)(in) + Mn(2+)(in) <=> H(+)(out) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60686", "l": "(11R)-dihydroartemisinate + 2 H(+) + NADPH => (11R)-dihydroartemisinic aldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696267", "l": "RND3 binds GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33121", "l": "(+)-sativene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29947", "l": "H(+)(in) + L-rhamnopyranose(in) = H(+)(out) + L-rhamnopyranose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610954", "l": "HCMV Final Envelopment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956568", "l": "RUNX1 binds the core TAL1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50165", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19268", "l": "carnitine + NAD(+) <=> 3-dehydrocarnitine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624256", "l": "Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029268", "l": "Phosphorylation and activation of PLCG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43165", "l": "7-cyano-7-deazaguanine + guanosine(15) in tRNA => 7-cyano-7-carbaguanosine(15) in tRNA + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15953", "l": "agmatine + ATP = ADP + 2 H(+) + N(4)-phosphoagmatine", "d": [], "t": []}, {"i": "EC:2.7.3.10", "l": "\"agmatine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168987", "l": "DLL4 binds NOTCH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41613", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O => D-ribose 2,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994148", "l": "LRRC16A binds F-actin capping protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77279", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78284", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => (-)-somaliensene B + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76057", "l": "H(+) + reticuline + S-adenosyl-L-homocysteine => norreticuline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008398", "l": "sterol 14-demethylase activity", "d": ["Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139919", "l": "Translocation of BIM to mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163625", "l": "Glucagon binds to Glucagon receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029456", "l": "RAC1 and CDC42 activate PAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52821", "l": "L-serine + succinyl-CoA => CoA + O-succinyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71155", "l": "TAT deaminates tyrosine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60659", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78170", "l": "2-epi-5-epi-valiolone + NAD(+) <=> demethylgadusol + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10996", "l": "2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.91", "l": "\"isobutyraldoxime O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66381", "l": "ATP + glutathione(in) + glycodeoxycholate(in) + H2O => ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60789", "l": "gibberellin A24 + H(+) + O2 => CO2 + gibberellin A9 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27730", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) = beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23773", "l": "(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) => 2,3-dihydroxy-p-cumate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175250", "l": "Suicidal integration leading to smaller circles of viral DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68678", "l": "adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+) => 3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24425", "l": "2 glutathione + L-dehydroascorbate => glutathione disulfide + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52909", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + O2 => 3-dimethylallyl-4-hydroxymandelate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68162", "l": "H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] => N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.942687253280909", "identifiers": [{"i": "GO:0016899", "l": "oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043863", "l": "4-hydroxy-2-ketopimelate aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29404", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 => 3-demethylubiquinol-8 + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473186", "l": "FSTL3 binds Activin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39361", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+) => (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19314", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296043", "l": "Activation of HCN channels (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34903", "l": "4 glutathione + 2 H(+) + selenite = glutathione disulfide + 3 H2O + selenodiglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11331", "l": "dimethylallyl diphosphate + isopentenyl diphosphate <=> diphosphate + neryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59215", "l": "holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP <=> AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53150", "l": "H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase] => N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0047555", "l": "3',5'-cyclic-GMP phosphodiesterase activity", "d": ["Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794336", "l": "NMDAR binds PSD-95 subfamily members (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56155", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70696", "l": "chloride(out) + glycine(out) + 3 Na(+)(out) => chloride(in) + glycine(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72004", "l": "(S)-lactate(in) + urate(out) => (S)-lactate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31928", "l": "3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036393", "l": "thiocyanate peroxidase activity", "d": ["Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25552", "l": "9alpha-copalyl diphosphate = diphosphate + stemar-13-ene", "d": [], "t": []}, {"i": "EC:4.2.3.33", "l": "\"stemar-13-ene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168849", "l": "tBID binds to inactive BAX protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73914", "l": "ATP + psilocin <=> ADP + H(+) + psilocybin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047476", "l": "3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity", "d": ["Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + diphosphate + AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607756", "l": "TRAF6 oligomer autoubiquitinates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044019", "l": "histone H3K72 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61869", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418856", "l": "Activation of Rac1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77943", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate = 1,3-di-(9Z)-hexadecenoylglycerol + 9-(9Z-hexadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71225", "l": "chloride(in) + 2 Na(+)(in) + taurine(in) => chloride(out) + 2 Na(+)(out) + taurine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246696", "l": "APC truncation mutants are not K63 polyubiquitinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17839", "l": "2-carboxy-D-arabinitol + phosphate => 2-carboxy-D-arabinitol 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692315", "l": "OX40L binds OX40 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14740", "l": "CTP <=> 3',5'-cyclic CMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9866272", "l": "2Fe-2S is inserted in UQCRFS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404135", "l": "RBP4 binds atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106375", "l": "deoxynucleoside triphosphate hydrolase activity", "d": ["Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate."], "t": []}, {"i": "RHEA:46148", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36431", "l": "a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602466", "l": "Activation of MT-MMPs by FURIN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878056", "l": "RUNX1:CBFB binds EP300 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796209", "l": "Expression of FOXA2 in the anterior primitive streak (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57179", "l": "L-arginyl-[protein] + methylglyoxal <=> N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12853", "l": "(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose = dhurrin + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.85", "l": "\"cyanohydrin beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54072", "l": "(2E)-geranyl diphosphate = beta-thujene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.177", "l": "\"beta-thujene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047807", "l": "cytokinin 7-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-7-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109857", "l": "MAP2K1 binds MAPK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37695", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964274", "l": "G alpha (12) binds BTK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23735", "l": "(R)-5-diphosphomevalonate + ATP <=> ADP + CO2 + isopentenyl diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11815", "l": "H2O + methanethiol + O2 <=> formaldehyde + H(+) + H2O2 + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63007", "l": "(11Z,14Z)-eicosadienamide + H2O <=> (11Z,14Z)-eicosadienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0008900", "l": "P-type potassium:proton transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400282", "l": "CRY proteins are ubiquitinylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65338", "l": "chrodrimanin A + H2O + NADP(+) => chrodrimanin T + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2453855", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102264", "l": "tRNA-dihydrouridine20 synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil20 in tRNA + NAD(P) = H+ + a uracil20 in tRNA + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49949", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + O2 => (10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44207", "l": "2-hydroxyhexadecanoate + ATP + CoA <=> 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54079", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + stellata-2,6,19-triene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295622", "l": "SPRY2 binds CBL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70306", "l": "beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-octanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187895", "l": "Engulfed CpG DNA binds to endosomal C-ter TLR9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37427", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102125", "l": "gibberellin A9 16alpha,17 epoxidase activity", "d": ["Catalysis of the reaction: gibberellin A9 + O2 + H+ + NAD(P)H = 16alpha, 17-epoxy gibberellin A9 + H2O + NAD(P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55205", "l": "5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine => 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69029", "l": "5beta-dihydrotestosterone + H(+) + NADPH => 5beta-androstane-3alpha,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.574107045986764", "identifiers": [{"i": "GO:0042054", "l": "histone methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44322", "l": "decanoate + glycerol + H(+) => 1-decanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77034", "l": "(2R)-heptan-2-amine + H2O + NAD(+) <=> H(+) + heptan-2-one + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052722", "l": "fatty acid in-chain hydroxylase activity", "d": ["Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.147", "l": "\"ADP-specific glucose/glucosamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.4", "l": "\"DNA 3'-5' helicase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17778", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16919", "l": "2,3,6-trihydroxypyridine + H2O + NAD(+) => 2,6-dihydroxypyridine + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44964", "l": "(2E)-dodecenoyl-CoA + H(+) + NADPH = dodecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42427", "l": "2-methylmaleate + H2O <=> (2R,3S)-3-methylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5660665", "l": "Caspase-8 binds MALT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57768", "l": "2-nitrotoluene + NADH + O2 = 3-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20654", "l": "23,24-dihydrocucurbitacin B + NAD(+) => cucurbitacin B + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912362", "l": "MIR150 microRNA binds 3'UTR of NOTCH3 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67202", "l": "acetate + tyramine => H2O + N-acetyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64655", "l": "(E)-4-coumaraldehyde + CoA + NADP(+) <=> (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44755", "l": "2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42419", "l": "a ubiquinone + L-proline <=> (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730903", "l": "Oligomerization of TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.62", "l": "\"glycosylceramidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854303", "l": "TBC1D11 binds RAB6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59091", "l": "D-histidine + S-adenosyl-L-methionine <=> (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186765", "l": "PLC-gamma binds to the active receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71198", "l": "H(+)(out) + Zn(2+)(out) <=> H(+)(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18136", "l": "ATP + H(+) + sulfate <=> adenosine 5'-phosphosulfate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40977", "l": "2 H(+) + 2 hexadecanoate + sn-glycerol 3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865491", "l": "RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51960", "l": "(Z)-2-methylpropanal oxime = 2-methylpropanenitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55606", "l": "a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030197", "l": "extracellular matrix constituent, lubricant activity", "d": ["Functions as a lubricant for an extracellular matrix, such as a mucous membrane."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22786", "l": "H(+) + phosphoenolpyruvate + sulfite => (2R)-O-phospho-3-sulfolactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50490", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72377", "l": "hydrogencarbonate(in) + iodide(out) => hydrogencarbonate(out) + iodide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59034", "l": "4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => (Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67660", "l": "an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3229181", "l": "CALM1:Ca2+ binds CNG channel (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351341", "l": "Exocytosis of Proactivator polypeptide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28502", "l": "NAD(+) + S-(hydroxymethyl)mycothiol = H(+) + NADH + S-formylmycothiol", "d": [], "t": []}, {"i": "EC:1.1.1.306", "l": "\"S-(hydroxymethyl)mycothiol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46572", "l": "2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23996", "l": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218906", "l": "RIPK3 phosphorylates MLKL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25179", "l": "3-methylbutanoyl-CoA + CO2 + NADH => 4-methyl-2-oxopentanoate + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867041", "l": "EGFR phosphorylates EPS15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18622", "l": "2-oxoglutarate + a (2S)-flavan-4-one + O2 => a (2R,3R)-dihydroflavonol + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0072320", "l": "volume-sensitive chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39722", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate <=> 24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23897", "l": "5-dehydro-4-deoxy-D-glucuronate => 3-deoxy-D-glycero-2,5-hexodiulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209910", "l": "Iodide is taken up by thyroid epithelial cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15126", "l": "acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n) => CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42524", "l": "uridine(1911/1915/1917) in 23S rRNA = pseudouridine(1911/1915/1917) in 23S rRNA", "d": [], "t": []}, {"i": "EC:5.4.99.23", "l": "\"23S rRNA pseudouridine(1911/1915/1917) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.24", "l": "\"biliverdin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140351", "l": "glycosylceramide flippase activity", "d": ["Catalysis of the movement of glycosylceramide from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Glycosylceramides are ceramides containing a functional group derived from a sugar."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43774", "l": "H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine => guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65124", "l": "benzoyl-CoA + ethanol = benzyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31638", "l": "beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33950", "l": "2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine <=> 2'-N-acetylparomamine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9842655", "l": "IRS1 recruits GRB2 to active LTK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68020", "l": "(2E)-geranyl phosphate + H2O = (2E)-geraniol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52238", "l": "3 A + Fe(2+) + 3 H2O + mycobilin b => 3 AH2 + 2 H(+) + heme b + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20948", "l": "3-sulfopyruvate + H(+) = CO2 + sulfoacetaldehyde", "d": [], "t": []}, {"i": "EC:4.1.1.79", "l": "\"sulfopyruvate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63022", "l": "(9Z,12Z)-octadecadienoate + NH4(+) => (9Z,12Z)-octadecadienamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25435", "l": "beta-D-ribopyranose <=> beta-D-ribofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70768", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38930", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56475", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708533", "l": "BACH1 translocates from the cytosol to the nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.297", "l": "\"limonene-1,2-diol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9714580", "l": "SLC6A3 binds DRIs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665417", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76529", "l": "2'-deoxyxanthosine + NH4(+) => 2'-deoxyguanosine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71114", "l": "L-phenylalanine(out) + S-methylmercury-L-cysteine(in) <=> L-phenylalanine(in) + S-methylmercury-L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174070", "l": "Association of Cdh1 with the APC/C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854302", "l": "TBC1D7 binds the TSC1-TSC2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61605", "l": "[DsbA protein]-dithiol + [DsbB protein]-disulfide => [DsbA protein]-disulfide + [DsbB protein]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015488", "l": "glucuronide:cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43849", "l": "[thioredoxin]-dithiol + arsenate + H(+) => [thioredoxin]-disulfide + arsenite + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77022", "l": "2-aminocyclohexanol + H2O + NAD(+) <=> 2-hydroxycyclohexan-1-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11948", "l": "4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.23", "l": "\"4-hydroxybenzoyl-CoA thioesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696547", "l": "STAMBPL1 is a deubiquitinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5660660", "l": "p300 acetylates RELA subunit (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44308", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phosphoethanolamine = 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47915", "l": "6-deoxy-6-sulfo-D-gluconate <=> 2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55836", "l": "calcitriol + UDP-alpha-D-glucuronate = calcitriol 25-O-(beta-D-glucuronide) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64164", "l": "2-methyl-L-serine = formaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2534096", "l": "METAP1/2 demethylates GNAT1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24276", "l": "acetate + diphosphate = acetyl phosphate + phosphate", "d": [], "t": []}, {"i": "EC:2.7.2.12", "l": "\"acetate kinase (diphosphate)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70599", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015152", "l": "glucose-6-phosphate transmembrane transporter activity", "d": ["Enables the transfer of glucose-6-phosphate from one side of a membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15993", "l": "anthraniloyl-CoA + 2 H(+) + 2 NADPH + O2 = 2-amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77112", "l": "1D-myo-inositol 1,2,3,5,6-pentakisphosphate + H2O => 1D-myo-inositol 1,2,3,6-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39111", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) = 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.616479785166973", "identifiers": [{"i": "GO:0017022", "l": "myosin binding", "d": ["Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202947", "l": "Caspase mediated cleavage of APC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45608", "l": "H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67694", "l": "ADP + H(+) + hexadecanedioate(out) + phosphate => ATP + H2O + hexadecanedioate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761852", "l": "NFE2L2-dependent TKT gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21292", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.153", "l": "\"phosphatidylinositol-4,5-bisphosphate 3-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9716258", "l": "Dimethyl fumarate modifies Cys191 in GSDMD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68877", "l": "ATP + H(+) + NADPH + piperonylate => AMP + diphosphate + NADP(+) + piperonal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27407", "l": "a ubiquinol + acetate + CO2 => a ubiquinone + H2O + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59013", "l": "cycloartenol + S-adenosyl-L-methionine => 24-methylenecycloartanol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54529", "l": "aldehydo-D-ribose 5-phosphate => D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362549", "l": "Hh-Np traffics to the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937814", "l": "RUNX3 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450533", "l": "PKCdelta phosphorylates HuR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174124", "l": "Dephosphorylation of phospho-Cdh1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15563", "l": "8-O-methylsterigmatocystin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + sterigmatocystin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43035", "l": "3-chloro-D-alanine <=> 2-aminoprop-2-enoate + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1449597", "l": "p-AKT2 phosphorylates Myosin 5A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187332", "l": "Cytosolic CMs translocate to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944233", "l": "Association of procollagen type XIX (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796081", "l": "EIF2AK3 phosphorylates NFE2L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13048", "l": "ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19743", "l": "CoA + formate + H(+) => formyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15341", "l": "ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.6.1.2", "l": "\"cobaltochelatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44817", "l": "1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-12 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13127", "l": "CoA-glutathione + glutathione => CoA + glutathione disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21545", "l": "(2E,6E)-farnesyl diphosphate + ATP => (2E,6E)-farnesyl triphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928598", "l": "Recruitment of p190RhoGEF to p-FAK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "62.431179124761442", "identifiers": [{"i": "GO:0016791", "l": "phosphatase activity", "d": ["Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27466", "l": "ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) => ADP-D-glycero-beta-D-manno-heptose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69777", "l": "beta-ylangene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56675", "l": "dihydro-4-coumaroyl-CoA + NADP(+) <=> (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74730", "l": "Insulin degradation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862184", "l": "USP48 cleaves polyubiquitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42736", "l": "guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.172", "l": "\"16S rRNA (guanine(1207)-N(2))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641246", "l": "ZNRF3 autoubiquitinates to promote its internalization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474266", "l": "Formation of collagen fibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73806", "l": "AIR + CO2 => CAIR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54910", "l": "(4E)-hexenoyl-CoA + NADP(+) => (2E,4E)-hexadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162194", "l": "COQ7:COQ9 octamer hydroxylates DMQ10H2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67399", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.82", "l": "\"ADAMTS-4 endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0016040", "l": "glutamate synthase (NADH) activity", "d": ["Catalysis of the reaction: 2 L-glutamate + NAD+ = 2-oxoglutarate + L-glutamine + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684261", "l": "MAP3K8 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19570", "l": "5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine => 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54492", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine = 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52315", "l": "NAD(+) + thromboxane B2 <=> 11-dehydro-thromboxane B2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158278", "l": "factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733960", "l": "Bile salts and acids dissociate from ALB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52850", "l": "5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine => 5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28346", "l": "7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate", "d": [], "t": []}, {"i": "EC:5.1.99.7", "l": "\"dihydroneopterin triphosphate 2'-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016250", "l": "N-sulfoglucosamine sulfohydrolase activity", "d": ["Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53649", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-corvol ether A + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72297", "l": "malate(in) + 3 Na(+)(in) => malate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76744", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecane => 7-tetradecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60434", "l": "AH2 + cannabichromenate => A + cannabigerolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9823904", "l": "TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13906", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10018", "l": "(E)-sinapate + choline + H(+) => H2O + O-sinapoylcholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0050492", "l": "glycerol-1-phosphate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953398", "l": "PIR oxygenates quercetin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15956", "l": "agmatine + ATP <=> ADP + 2 H(+) + N(4)-phosphoagmatine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32882", "l": "(1R,4R,5R)-5-hydroxycamphor + NAD(+) <=> (1R,4R)-bornane-2,5-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70272", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate => 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9851972", "l": "PLK1 phosphorylates FIRRM at S43 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53113", "l": "3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) => 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75849", "l": "SLC25A1 exchanges CIT and MAL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20441", "l": "L-cysteine + O2 = 3-sulfino-L-alanine + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.20", "l": "\"cysteine dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44208", "l": "12-methyltridecanoate + ATP + CoA = 12-methyltridecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160187", "l": "paracellular tight junction channel activity", "d": ["Enables size- and charge-selective transport of solutes through a tight junction barrier paracellularly, across the epithelium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0099101", "l": "G-protein gated potassium channel activity", "d": ["A potassium channel activity that is gated by binding of a G-protein beta-gamma dimer."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13023", "l": "3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15895", "l": "Co(2+) + sirohydrochlorin => Co-sirohydrochlorin + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140890", "l": "H1 histone chaperone activity", "d": ["A histone chaperone that carries a H1 histone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74992", "l": "deoxyerythrostominone(in) => deoxyerythrostominone(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76015", "l": "(3R)-hydroxybutanoate trimer + H2O = (3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18506", "l": "L-lysine + NAD(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42157", "l": "androsterone + H(+) + NADPH => 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67305", "l": "3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 => H2O2 + myceliothermophin E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48289", "l": "a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate => a ganglioside GD3 + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052658", "l": "inositol-1,4,5-trisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28844", "l": "choline(in) + H(+)(in) => choline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236398", "l": "ERBB4 binds NRGs or EGF-like ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31624", "l": "L-olivosyl-oleandolide + S-adenosyl-L-methionine => H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9824894", "l": "TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45409", "l": "(2E)-dodecenoyl-CoA + H(+) + NADH => dodecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57031", "l": "FADH2 + N-methylnicotinate + O2 <=> (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47923", "l": "ganglioside GM2 (d18:1(4E)/18:0) + H2O <=> ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202721", "l": "JAM2 binds JAM3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871260", "l": "YAP1 binds TEAD2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042731", "l": "PH domain binding", "d": ["Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46027", "l": "H2O2 + tetradecanoate <=> (3R)-hydroxytetradecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39930", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60323", "l": "N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51481", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814096", "l": "ARL1:GTP binds SCOC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19723", "l": "(9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013158", "l": "CDC42 GDIs block activation of CDC42 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65547", "l": "a ganglioside GM1 + H2O <=> an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60621", "l": "N-hexanoyl-sphing-4-enine-1-phosphocholine => choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35322", "l": "H(+) + malonyl-CoA + octadecanoyl-CoA <=> 3-oxoeicosanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64244", "l": "a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18806", "l": "[DsbA protein]-disulfide + [protein]-dithiol => [DsbA protein]-dithiol + [protein]-disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53242", "l": "cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690669", "l": "CD22 binds itself to form homo-oligomers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800044", "l": "TP53 stimulates IGFBP3 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0019957", "l": "C-C chemokine binding", "d": ["Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047311", "l": "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity", "d": ["Catalysis of the reaction: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109470", "l": "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38247", "l": "(9Z)-hexadecenoyl-CoA + hexadecan-1-ol = 1-O-hexadecyl (9Z)-hexadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202248", "l": "Phosphorylation of PLC-gamma1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944240", "l": "Association of procollagen type III (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67612", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73161", "l": "FMN(in) + NAD(+)(out) => FMN(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635859", "l": "GLI:SUFU dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856548", "l": "MLXIPL:MLX binds ACACB gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39197", "l": "(3R)-hydroxytetracosanoyl-CoA + NADP(+) => 3-oxotetracosanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60207", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57745", "l": "[protein]-disulfide + phylloquinol => [protein]-dithiol + phylloquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58677", "l": "NADPH + O2 + rifamycin SV => H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451856", "l": "FT is phosphorylated by DCO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51724", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = adenosine 5'-tetraphosphate + ADP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139906", "l": "Activation of BAD by calcineurin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57475", "l": "(E)-4-coumarate + UDP-alpha-D-glucose <=> 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22654", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate => 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836993", "l": "GRSF1 binds RNA containing quadruplex guanosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44639", "l": "2,4-dinitroanisole + H2O <=> 2,4-dinitrophenol + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110307", "l": "REV1 binds AP-dsDNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61365", "l": "ATP + dehydroepiandrosterone 3-sulfate(in) + H2O => ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25166", "l": "(2E)-butenoyl-CoA + AH2 => A + butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45150", "l": "3-hydroxy-3-(methylsulfanyl)propanoyl-CoA => 3-(methylsulfanyl)acryloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51294", "l": "a quinol + L-methionyl-(S)-S-oxide-[protein] => a quinone + H2O + L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023617", "l": "Butyrylcholinesterase hydrolyzes acyl Ghrelin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35016", "l": "riboflavin(in) => riboflavin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73800", "l": "SAICAR => AICAR + Fumarate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102321", "l": "2,2'-hydroxybiphenyl monooxygenase activity", "d": ["Catalysis of the reaction: biphenyl-2,2'-diol + O2 + NADH + H+ = biphenyl-2,2',3-triol + H2O + NAD."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683606", "l": "Nucleoprotein translocates to the nucleolus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72302", "l": "3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16184", "l": "3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49261", "l": "D-galactose(out) + N(pros)-phospho-L-histidyl-[protein] => D-galactose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77363", "l": "2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62667", "l": "(2'R)-atrovenetin + S-adenosyl-L-methionine <=> deoxyherqueinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66442", "l": "but-3-en-2-one + H(+) + NADPH => butan-2-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051982", "l": "copper-nicotianamine transmembrane transporter activity", "d": ["Enables the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67996", "l": "(Z)-1,2-dichloroethene + AH2 = A + chloride + chloroethene + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19231", "l": "an aromatic carboxylate + ATP + H(+) + NADPH => AMP + an aromatic aldehyde + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58044", "l": "a long-chain fatty acyl-CoA + alpha,alpha-trehalose = 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.279", "l": "\"long-chain-acyl-CoA--trehalose acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62091", "l": "D-glucosamine 6-phosphate + NADP(+) <=> 2-amino-2-deoxy-6-phospho-D-glucono-1,5-lactone + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814831", "l": "TBC1D20 binds RAB1:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-213406", "l": "Disassociation of PLC-gamma1 from LAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55365", "l": "(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 6 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140628", "l": "outward rectifier potassium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102960", "l": "momilactone-A synthase activity", "d": ["Catalysis of the reaction: 3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NAD(P) = momilactone A + H+ + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66389", "l": "ATP + H2O + prostaglandin E2(in) => ADP + H(+) + phosphate + prostaglandin E2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52656", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) = a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.211", "l": "\"long-chain-3-hydroxyacyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32421", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADH => (1S,2R,4R)-neoisodihydrocarveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0035368", "l": "selenocysteine insertion sequence binding", "d": ["Binding to a selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31462", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate <=> 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39777", "l": "17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69386", "l": "(3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein] => (R)-carnitine + Co(I)-[quaternary-amine-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11159", "l": "H2O + L-valine + NADP(+) <=> 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190265", "l": "FGFR4 binds to FGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218811", "l": "DOCK180:ELMO binds CRK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66405", "l": "ATP + glutathione(in) + H2O + taurocholate(in) => ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43344", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) = [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.73", "l": "\"sulfur carrier protein ThiS adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035982", "l": "Defective HEXB does not cleave the terminal GalNAc from HA fragments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14660", "l": "aldehydo-D-ribose 5-phosphate <=> D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655244", "l": "Activated FGFR3 point and translocation mutants bind PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834736", "l": "Synthesis of antigenomic RNA of human respiratory syncytial virus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018746", "l": "RHOQ binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57524", "l": "a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43959", "l": "15-methylhexadecanoate + H(+) + NADPH + O2 <=> H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55014", "l": "(3R)-3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => (1S,4R)-1-hydroxylimonen-2-one + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42186", "l": "17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH => 5alpha-androstane-3beta,17beta-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28328", "l": "D-glucuronate + H(+) + wogonin => H2O + wogonin 7-O-beta-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9861667", "l": "DLAT trimer transfers acetyl to CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3858475", "l": "ppDVL recruits RAC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23847", "l": "ATP + sedoheptulose <=> ADP + D-sedoheptulose 7-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53673", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 => 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20363", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37973", "l": "(9Z)-octadecenoyl-CoA + 2 H2O + NADP(+) => H(+) + NADPH + O2 + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48360", "l": "a 1,2-saturated fatty acid + H2O2 = a 2-hydroxy fatty acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139920", "l": "Translocation of tBID to mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296309", "l": "HCAR3 binds HCAR3 ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60018", "l": "diphosphate + sesquisabinene B => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350901", "l": "Iodide is organified (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140800", "l": "gamma-aminobutyric acid:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4-aminobutanoate(out) + H+(in) = 4-aminobutanoate(in) + H+(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848215", "l": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19056", "l": "5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O <=> H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58481", "l": "a cytidine in mRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10384", "l": "cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate = beta-cyclopiazonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418553", "l": "cAMP degradation by Phosphodiesterases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033871", "l": "[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16210", "l": "Co-precorrin-8X => cob(II)yrinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15609", "l": "ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.6.1", "l": "\"ribose-phosphate diphosphokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65552", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = an N-acyl-sphingoid base + lactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77685", "l": "a globoside GalGb3Cer (d18:1(4E)) + H(+) + UDP => a globoside Gb3Cer (d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42666", "l": "H(+) + L-arabinono-1,4-lactone + NADPH => alpha-L-arabinopyanose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021406", "l": "NOTCH3 coactivator complex binds PBX1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44649", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 2-acyl-sn-glycerol 3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72621", "l": "Ribosomal scanning  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75345", "l": "adenosine(out) => adenosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21430", "l": "H(+) + pyruvate + sulfite => (2R)-3-sulfolactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112727", "l": "Serine phosphorylation of STATs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614933", "l": "ACEIs bind ACE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38260", "l": "(2R,3S)-beta-methylmalyl-CoA => glyoxylate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624953", "l": "ARL13B binds INPP5E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38596", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61172", "l": "myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9854961", "l": "SDHAF4 binds to FAD-SDHA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-914036", "l": "SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9606151", "l": "Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636242", "l": "PPE2:KPNA1:KPNB1 dissociates, releasing PPE2 into the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218812", "l": "FYN phosphorylates PAK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17165", "l": "alpha-D-galactose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-D-galactose", "d": [], "t": []}, {"i": "EC:2.7.7.32", "l": "\"galactose-1-phosphate thymidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45140", "l": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O = CO2 + L-glutamyl-[protein] + O2 + phylloquinol", "d": [], "t": []}, {"i": "EC:4.1.1.90", "l": "\"peptidyl-glutamate 4-carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57298", "l": "a 2'-deoxyguanosine in DNA + glycolate + H(+) => an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53183", "l": "D-erythrose <=> D-erythrulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40337", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.13", "l": "\"sterol esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042945", "l": "D-serine transmembrane transporter activity", "d": ["Enables the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37517", "l": "1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51510", "l": "CO2 + succinate + trans-4-hydroxy-L-proline => 2-oxoglutarate + L-proline + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6799350", "l": "Exocytosis of specific granule membrane proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72722", "l": "eIF2 activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452108", "l": "Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50463", "l": "a medium chain fatty acid + ATP + holo-[ACP] <=> a medium-chain fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29458", "l": "D-serine(in) <=> D-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56303", "l": "[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] <=> [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70556", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O => L-seryl-[protein] + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67064", "l": "AH2 + asnovolin K = A + asnovolin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646390", "l": "Misfolded proteins:HDAC6:Dynein motor binds microtubule (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0052655", "l": "L-valine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26512", "l": "L-proline + NH4(+) => H2O + L-prolinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57118", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61181", "l": "quercetin + UDP-alpha-D-glucose => H(+) + quercetin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13928", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine <=> holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63983", "l": "4-thiouridine + ATP <=> 4-thiouridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17667", "l": "H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein] => L-lysyl-[protein] + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66535", "l": "ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] <=> diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706344", "l": "FLT3 phosphorylates GRB10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13986", "l": "ATP + L-homoserine => ADP + H(+) + O-phospho-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14609", "l": "D-sorbitol + NADP(+) = H(+) + keto-L-sorbose + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.289", "l": "\"sorbose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374701", "l": "Phosphorylation of DCC by Fyn (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010542", "l": "nitrate efflux transmembrane transporter activity", "d": ["Enables the transfer of nitrate from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37961", "l": "(13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36798", "l": "a ribonucleoside 5'-triphosphate + 2 H2O <=> a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61818", "l": "16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP => 16,17-didehydropregnenolone + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39227", "l": "(2E)-octacosenoyl-CoA + H(+) + NADPH = NADP(+) + octacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.-", "l": "\"In ketonic substances\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66616", "l": "Mg(2+)(in) + 2 Na(+)(out) = Mg(2+)(out) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45531", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.60", "l": "\"2-hydroxy-3-oxopropionate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12279", "l": "3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31236", "l": "(4S)-4-hydroxy-L-glutamate + 2-oxoglutarate => (4R)-4-hydroxy-2-oxoglutarate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047777", "l": "(S)-citramalyl-CoA lyase activity", "d": ["Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41907", "l": "3-oxohexadecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-205136", "l": "GTP-bound RAC contributes to JNK activation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32484", "l": "H(+) + H2O + pheophorbide a => CO2 + methanol + pyropheophorbide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001181", "l": "RNA polymerase I general transcription initiation factor activity", "d": ["A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433506", "l": "Phosphorylation of APS (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42637", "l": "AH2 + L-cysteine + Mo-molybdopterin => A + H2O + L-alanine + thio-Mo-molybdopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871227", "l": "RET binds GFRA4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004794", "l": "threonine deaminase activity", "d": ["Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044103", "l": "L-arabinose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+."], "t": []}, {"i": "EC:1.1.1.376", "l": "\"L-arabinose 1-dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14769", "l": "(S)-nicotine + A + H2O = (S)-6-hydroxynicotine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021660", "l": "PI3K binds membrane-associated estrogen receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71677", "l": "glycyl-L-leucine(in) + H(+)(in) => glycyl-L-leucine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60622", "l": "choline + N-(hexanoyl)-sphing-4-enine-1,3-cyclic phosphate => N-hexanoyl-sphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140806", "l": "SERPINC1 binds SERPINC1 activators (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47142", "l": "(6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21725", "l": "a nitrile + 2 H2O => a carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47057", "l": "4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34017", "l": "ergosterol + 2 H2O + NADP(+) => ergosta-5,7-dien-3betabeta-ol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005304", "l": "L-valine transmembrane transporter activity", "d": ["Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381087", "l": "Dimerization of PERK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70936", "l": "L-lysine(in) => L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.58", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9859163", "l": "DBT transfers BCAA to CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12915", "l": "(R)-lipoyl-5'-AMP + diphosphate => (R)-lipoate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24054", "l": "a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein] => a ubiquinone + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666430", "l": "p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24773", "l": "7(1)-hydroxychlorophyllide a + NADP(+) => chlorophyllide b + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13471", "l": "5-methylbarbiturate + AH2 + H(+) => A + H2O + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45324", "l": "H2O + N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine = H(+) + N-tetracosanoyl-sphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199144", "l": "Nectin 2 binds CD226 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903981", "l": "enterobactin binding", "d": ["Binding to enterobactin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937369", "l": "ATAD2 binds ESR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49470", "l": "a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592398", "l": "Activation of proMMP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35261", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042169", "l": "SH2 domain binding", "d": ["Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28513", "l": "arbutin 6-phosphate + H2O <=> beta-D-glucose 6-phosphate + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71094", "l": "dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) <=> dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685953", "l": "SIRT6 deacetylates RBBP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210294", "l": "Interaction of PECAM-1 and SHP-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46476", "l": "4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72226", "l": "4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) <=> 4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38654", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58179", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADPH <=> all-trans-lycopaoctaene + 2 diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205056", "l": "PRDM4 inhibits cyclin E transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114254", "l": "CYCS binds to APAF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15403", "l": "a dolichyl beta-D-glucosyl phosphate + UDP => a dolichyl phosphate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16637", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.16", "l": "\"chitin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022378", "l": "ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31450", "l": "6-amino-2-oxohexanoate + H2O2 <=> 5-aminopentanoate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40717", "l": "1-hexadecanoylglycerone 3-phosphate + CoA => dihydroxyacetone phosphate + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047511", "l": "(S)-methylmalonyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: (S)-methylmalonyl-CoA + H2O = CoA + H+ + methylmalonate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57857", "l": "(E)-feruloyl-CoA + 2-oxoglutarate + O2 => (E)-6-hydroxyferuloyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49085", "l": "(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] => (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77561", "l": "a 1,3-diacyl-sn-glycerol + CoA => a 1-acyl-sn-glycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60359", "l": "H2O + N-octanoylanthranilate <=> anthranilate + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42255", "l": "H(+) + malonyl-[ACP] + pentanoyl-CoA <=> 3-oxoheptanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12468", "l": "avenacoside A + H2O = 26-desgluco-avenacoside A + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30985", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein] => H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47391", "l": "a tetradecanoate ester + H2O <=> an aliphatic alcohol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76416", "l": "Benzene is hydroxylated to phenol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77585", "l": "1-octadecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67085", "l": "ATP + H2O + hexacosanoate(in) => ADP + H(+) + hexacosanoate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430347", "l": "MigFilin associates with Filamin and F-actin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4570553", "l": "SUMOylation of MDC1 with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034868", "l": "2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA = 2,4,4-trimethyl-3-oxopentanoyl-CoA + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938938", "l": "RUNX1 and ELF1 bind the IL3 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5681987", "l": "LC3 is cleaved by ATG4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52033", "l": "H2O + L-isoleucine-(+)-7-isojasmonate => (+)-7-isojasmonate + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047910", "l": "galactose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52604", "l": "3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-seryl-[protein] + ATP = 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-6-O-phospho-alpha-D-mannosyl)-L-seryl-[protein] + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033810", "l": "anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54547", "l": "1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + 2-heptanoyl-sn-glycero-3-phosphocholine <=> 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine + hexanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21243", "l": "geranylgeranyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76831", "l": "H2O + hexylamine + NAD(+) = H(+) + hexanal + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41841", "l": "3-oxooctanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyoctanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48576", "l": "4-chlorocatechol + O2 = 3-chloro-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58849", "l": "(6E)-8-hydroxygeraniol + NAD(+) => (6E)-8-hydroxygeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19026", "l": "H2O + L-aspartate + O2 => H2O2 + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29711", "l": "cadaverine(in) + H(+)(in) = cadaverine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59644", "l": "D-xylobiono-1,5-lactone + H2O = D-xylobionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109858", "l": "MAP2K2 binds MAPK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202966", "l": "Caspase mediated cleavage of HIP-55 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45118", "l": "H(+) + ipsdienone + NADPH => (4R)-ipsdienol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5660666", "l": "CBP and p300 binds NF-kB complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9845516", "l": "B3GALT4 transfers Gal to gangliosides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0004949", "l": "cannabinoid receptor activity", "d": ["Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0051864", "l": "histone H3K36 demethylase activity", "d": ["Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213195", "l": "Formation of anchoring fibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51258", "l": "(9S,16S)-dihydroperoxy-(10E,12Z,14E)-octadecatrienoate => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052598", "l": "histamine oxidase activity", "d": ["Catalysis of the reaction: histamine + H2O + O2 = imidazole-4-acetaldehyde + NH3 + hydrogen peroxide + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52435", "l": "(R)-2,3-diaminopropanoate + H(+) + H2O <=> 2 NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40262", "l": "(2E)-hexadecenedioyl-CoA + H2O <=> (3S)-hydroxyhexadecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54038", "l": "[mycoredoxin]-S-mycothiol-L-cysteine + arsenite => [mycoredoxin]-L-cysteine + arseno-mycothiol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047820", "l": "D-glutamate cyclase activity", "d": ["Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69053", "l": "RFC binding displaces Pol Alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193715", "l": "5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77565", "l": "1-(9Z-octadecenoyl)-3-hexadecanoylglycerol + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2509838", "l": "ITPA hydrolyses dITP to dIMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42387", "l": "4,4'-diaponeurosporenal + H2O + NAD(+) <=> 4,4'-diaponeurosporenoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46885", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47078", "l": "17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+) => 17beta-hydroxyandrosta-1,4-dien-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74893", "l": "CO2(in) => CO2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9853369", "l": "PLK1 phosphorylates FIRMM at S744 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38023", "l": "gamma-tocotrienol = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42521", "l": "uridine(2605) in 23S rRNA => pseudouridine(2605) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65495", "l": "[mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680836", "l": "NS5B binds ribavirin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67933", "l": "ATP + desmosterol(in) + H2O => ADP + desmosterol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14608", "l": "D-glucose 6-phosphate + GDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17881", "l": "H2O + N-sulfo-D-glucosamine = D-glucosamine + sulfate", "d": [], "t": []}, {"i": "EC:3.10.1.1", "l": "\"N-sulfoglucosamine sulfohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14428", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33645", "l": "(9Z)-tetradecenoyl-CoA + AMP + diphosphate => (9Z)-tetradecenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45994", "l": "(2E)-decenoyl-CoA + H2O => (3R)-3-hydroxydecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55460", "l": "11-hydroxyferruginol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 11-hydroxysugiol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392831", "l": "Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55001", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine => 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56793", "l": "2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] => 2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8986083", "l": "USP33 deubiquitinates ROBO1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66625", "l": "cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008255", "l": "ecdysis-triggering hormone activity", "d": ["The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53407", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49334", "l": "2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21415", "l": "NAD(+) + sn-glycerol 1-phosphate <=> dihydroxyacetone phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73735", "l": "O2 + trans-resveratrol = 3,5-dihydroxybenzaldehyde + 4-hydroxybenzaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824593", "l": "MITF-M-dependent TYRP1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49628", "l": "acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine = 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67833", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(27)-[histone H3] + O2 => CO2 + formaldehyde + L-lysyl(27)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102931", "l": "(Z,E)-alpha- farnesene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693356", "l": "CEMIP hydrolyses HA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13163", "l": "(2S)-2-amino-3-oxobutanoate + H(+) + NADH => L-threonine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647977", "l": "ICMT methylates S-Farn RAS proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75696", "l": "2'-deoxycytidine(in) => 2'-deoxycytidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10360", "l": "3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl)propanoate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.35", "l": "\"dihydrocoumarin hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33874", "l": "(S)-2-ureidoglycine + H2O <=> glyoxylate + NH4(+) + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58510", "l": "(2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => (3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15551", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O => S-methyl-5-thio-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005175", "l": "CD27 receptor binding", "d": ["Binding to a CD27, a receptor found on the surface of T cells and some B cells and NK cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18995", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707683", "l": "PGRMC2 binds Hemes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16827", "l": "ADP + H(+) + UMP => ATP + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32337", "l": "(1S,4R)-fenchone + H(+) + NADPH => (1S,2S,4R)-endo-fenchol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0047023", "l": "androsterone dehydrogenase activity", "d": ["Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37611", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798374", "l": "DYRK2 phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72607", "l": "(E)-sinapoyl-AMP + CoA = (E)-sinapoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848077", "l": "PTK6 phosphorylates STAP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59911", "l": "H2O + hexanal + NADP(+) <=> 2 H(+) + hexanoate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30962", "l": "9,9'-di-cis-zeta-carotene + a quinone <=> 7,9,9'-tri-cis-neurosporene + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23527", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol <=> an alkyl cinnamate + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14889", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate", "d": [], "t": []}, {"i": "EC:5.3.3.13", "l": "\"polyenoic fatty acid isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38296", "l": "(R)-2-hydroxyglutarate + A => 2-oxoglutarate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730858", "l": "Autophosphorylation of BTK/ITK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2213207", "l": "Formation of collagen networks (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12442", "l": "2-oxoglutarate + H(+) + L-lysine + NADH => H2O + L-saccharopine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112392", "l": "Resumption of elongation after recovery from pausing (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59566", "l": "H(+) + N,N',N'',N'''-tetraacetylchitotetraonate => H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52068", "l": "9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8873850", "l": "STARD5 binds DCA, LCA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160126", "l": "pH-gated calcium channel activity", "d": ["A gated channel activity that enables the transmembrane transfer of a calcium ion by a channel that opens in response to a change in pH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022065", "l": "DSPGs are secreted (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13998", "l": "3-methyl-2-oxobutanoate + CoA + NAD(+) => 2-methylpropanoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036143", "l": "kringle domain binding", "d": ["Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65157", "l": "2-oxoglutarate + O2 + preaustinoid A2 => CO2 + H2O + preaustinoid A3 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-976743", "l": "Factor I inactivates plasma Factor H-bound C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30703", "l": "H(+) + salicylate = CO2 + phenol", "d": [], "t": []}, {"i": "EC:4.1.1.91", "l": "\"salicylate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41133", "l": "1-decanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-decanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50897", "l": "8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O => (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389350", "l": "Activation of Cdc42 by pVav1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33814", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine <=> 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016738", "l": "oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen."], "t": []}, {"i": "EC:1.19.6.-", "l": "\"With dinitrogen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605717", "l": "GM2A binds and mobilizes ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63636", "l": "a medium-chain fatty acyl-AMP + holo-[ACP] = a medium-chain fatty acyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928619", "l": "PAK1 binds RAC1:GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41727", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11R)-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41763", "l": "a ganglioside GM3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GD3 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17465", "l": "H2O + quercitrin = L-rhamnopyranose + quercetin", "d": [], "t": []}, {"i": "EC:3.2.1.40", "l": "\"alpha-L-rhamnosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28183", "l": "(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate => (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21396", "l": "(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) = CO2 + Na(+)(out) + propanoyl-CoA", "d": [], "t": []}, {"i": "EC:7.2.4.3", "l": "\"(S)-methylmalonyl-CoA decarboxylase (sodium-transporting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111915", "l": "CAMK4 autophosphorylates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928640", "l": "PAKs phosphorylate MLC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9687828", "l": "O-GlcNAcylation of RIPK3 (TLR4 signaling) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008942", "l": "nitrite reductase [NAD(P)H] activity", "d": ["Catalysis of the reaction: NH4+ + 3 NAD(P)+ + 2 H2O = nitrite + 3 NAD(P)H + 5 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682011", "l": "LC3 binds ATG7 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169719", "l": "Secreted CD14 binds LPS (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66153", "l": "acetyl-CoA + noradrenaline => CoA + H(+) + N-acetylnoradrenaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26537", "l": "3-hydroxypropanoate + ATP + CoA <=> 3-hydroxypropanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73511", "l": "2-oxoglutarate + 8-hydroxysalvigenin + O2 = CO2 + formaldehyde + pilosin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14599", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+) => a CDP-1,2-diacyl-sn-glycerol + choline", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74171", "l": "an N-methyl carbamate ester + H(+) + H2O = an alcohol + CO2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57022", "l": "ADP + apulose 4-phosphate + H(+) => apulose + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828204", "l": "IKKε (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952128", "l": "RUNX3 binds TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17378", "l": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] => 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58198", "l": "acetate + L-lysyl-[histone] => H2O + N(6)-acetyl-L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38830", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63926", "l": "ADP + H(+) + N(4)-acetylcytidine 5'-phosphate => ATP + N(4)-acetylcytidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814555", "l": "Integrator complex processes the 3' end of snRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18261", "l": "H2O + precorrin-5 + S-adenosyl-L-methionine = acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.152", "l": "\"precorrin-6A synthase (deacetylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60409", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35559", "l": "H(+) + menaquinone-7 + NADH = menaquinol-7 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71566", "l": "5-aminomethyl-dUMP in DNA + acetyl-CoA <=> 5-acetylaminomethyl-dUMP in DNA + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55419", "l": "biochanin A + UDP-alpha-D-glucose <=> biochanin A 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613497", "l": "Unwinding DNA for the nascent transcript (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22537", "l": "(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine => (S)-tetrahydropalmatine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694441", "l": "CSNK1D phosphorylates SEC23 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186785", "l": "PDGF-AA clevage by Furin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28757", "l": "a ubiquinol + dihydroxyacetone phosphate => a ubiquinone + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22465", "l": "L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75849", "l": "9-cis-4-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9-cis-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24223", "l": "beta-myrcene + O2 + reduced [NADPH--hemoprotein reductase] <=> (4R)-ipsdienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.124", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57865", "l": "indole-3-carbonyl nitrile + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxy-indole-3-carbonyl nitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34405", "l": "(11R)-carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal => 9-cis-10'-apo-beta-carotenal + 2 O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53494", "l": "5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out) => 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58319", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39034", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose <=> a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034890", "l": "endosulfan diol hydrolyase (cyclizing) activity", "d": ["Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44393", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA => 1-heptadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507868", "l": "Aquaporins passively transport water into cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76318", "l": "L-aspartate(in) + L-methionine(out) <=> L-aspartate(out) + L-methionine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0051428", "l": "peptide hormone receptor binding", "d": ["Binding to a receptor for a peptide hormone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944263", "l": "Association of procollagen type II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45416", "l": "2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 + H2O = 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.145607380047934", "identifiers": [{"i": "GO:0016790", "l": "thiolester hydrolase activity", "d": ["Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A."], "t": []}, {"i": "EC:3.1.2.-", "l": "\"Thiolester hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22942", "l": "ADP + H(+) + N(omega)-phospho-L-arginine => ATP + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50077", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76855", "l": "2-aminopentane + H2O + NAD(+) = H(+) + NADH + NH4(+) + pentan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983266", "l": "Kinesins bind microtubules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008671", "l": "2-dehydro-3-deoxygalactonokinase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035851", "l": "Krueppel-associated box domain binding", "d": ["Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76561", "l": "ergosterol + H(+) + L-aspartate => 1-(ergostan-3beta-yl)-L-aspartate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37608", "l": "(6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17615", "l": "H(+) + NADH + scyllo-inosose => NAD(+) + scyllo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8853496", "l": "SCF:FBXL7 binds AURKA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160935", "l": "SMURF1 ubiquitinates RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202164", "l": "Translocation of PDK1 to Plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48808", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16155", "l": "an aldehyde + H2O2 + NH4(+) => a primary methyl amine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60166", "l": "an N(7)-methylguanosine in RNA + S-adenosyl-L-homocysteine => a guanosine in RNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36427", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001058", "l": "RNA polymerase V activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11085", "l": "3-dehydro-L-gulonate + H(+) => CO2 + L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770063", "l": "S1,S2 Dissociate from S1:ACE2:S2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78114", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine <=> a 2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187293", "l": "SMAD2/3:SMAD4 complex positively regulates JUNB transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50635", "l": "a 2-(omega-methylsulfanyl)alkylmalate <=> a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198714", "l": "ERK5 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730904", "l": "Auto-ubiquitination of TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42812", "l": "cholesterol + octadecanoyl-CoA = cholesteryl octadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73421", "l": "L-glutamine(in) => L-glutamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21385", "l": "L-phenylalanine => (E)-cinnamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954207", "l": "ERBB4s80:ESR1 binds CXCL12 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35393", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + CO2 + CoA => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682377", "l": "LC3 de-lipidation by ATG4 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16576", "l": "2-oxoglutarate + 4-(phosphooxy)-L-threonine <=> (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69017", "l": "3alpha-hydroxy-5beta-pregnan-20-one + NADP(+) => 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41370", "l": "1-O-tetradecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-tetradecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66526", "l": "L-ascorbate(out) + monodehydro-L-ascorbate radical(in) => L-ascorbate(in) + monodehydro-L-ascorbate radical(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392152", "l": "Soluble guanylate cyclase converts GTP to cGMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140661", "l": "cytoskeletal motor inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a motor protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23683", "l": "a ribonucleoside 5'-triphosphate + H2O <=> a ribonucleoside 5'-diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865275", "l": "PDGF-BB clevage by Furin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.41", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10707", "l": "ATP + L-valine + tRNA(Val) <=> AMP + diphosphate + L-valyl-tRNA(Val)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54196", "l": "N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39449", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+) => (8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.89", "l": "\"tRNA-dihydrouridine(47) synthase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39687", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA = (2E,11Z)-octadecadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20325", "l": "N-hydroxy-4-acetylaminobiphenyl = N-acetoxy-4-aminobiphenyl", "d": [], "t": []}, {"i": "EC:2.3.1.56", "l": "\"aromatic-hydroxylamine O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201685", "l": "Beta-catenin is released from the destruction complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029273", "l": "PI3K binds to p-6Y-SYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391942", "l": "IP receptor can bind prostacyclin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57186", "l": "S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] => L-cysteinyl-[protein] + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372977", "l": "succinylCoA + ADP + Pi <=> succinate + CoASH + ATP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23733", "l": "(R)-5-diphosphomevalonate + ATP => ADP + CO2 + isopentenyl diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690873", "l": "ACO1 binds 4Fe-4S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59545", "l": "N,N'-diacetylchitobiose + O2 => H2O2 + N,N'-diacetylchitobiono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186819", "l": "SH2 domain of Src binds to the active receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605797", "l": "SMPD1 hydrolyzes SPHM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77831", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-glutamate + O2 = 2-dehydro-D-glucose + H2O2 + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327746", "l": "FN1 aggregation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789072", "l": "PGLYRP1 binds bacterial peptidoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022872", "l": "protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70580", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24664", "l": "2 N(omega)-hydroxy-L-arginine + NADPH + 2 O2 = H(+) + 2 H2O + 2 L-citrulline + NADP(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75773", "l": "(10S)-hydroxy-(12Z,15Z)-octadecadienoate => (9Z,12Z,15Z)-octadecatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13037", "l": "ATP + H(+) + H2O = ITP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.97", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193684", "l": "p62 recruits an atypical PKC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39216", "l": "(2E)-hexacosenoyl-CoA + H(+) + NADPH => hexacosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54599", "l": "2-oxoglutarate + hexadecanoyl-CoA + O2 <=> 2-hydroxyhexadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070728", "l": "L-leucine binding", "d": ["Binding to L-leucine, 2-amino-4-methylpentanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47692", "l": "AH2 + neomycin C + S-adenosyl-L-methionine = 5'-deoxyadenosine + A + H(+) + L-methionine + neomycin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936747", "l": "cleavage of L-cysteine from carrier protein (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357472", "l": "PAK1-3 autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047823", "l": "D-glutamyltransferase activity", "d": ["Catalysis of the reaction: D-glutamate + D-glutamine = gamma-D-glutamyl-D-glutamate + NH4+. Can also transfer additional glutamyl residues to a peptide, extending the polypeptide chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64337", "l": "H(+) + 2 malonyl-CoA + nicotinyl-CoA => 4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63263", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH <=> 4-pyridoxate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036134", "l": "12-hydroxyheptadecatrienoic acid synthase activity", "d": ["Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71837", "l": "estrone 3-sulfate(in) => estrone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28783", "l": "H2O + L-cysteinylglycine = glycine + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29634", "l": "D-maltotetraose + H2O <=> alpha-D-glucose + D-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77760", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol => 1-O-alkyl-sn-glycero-3-phosphocholine + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156930", "l": "GTP-binding activates eEF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24312", "l": "L-lysyl-[cytochrome c] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.59", "l": "\"[cytochrome c]-lysine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026911", "l": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77696", "l": "a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GM1alpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693478", "l": "HTR1A binds HTR1A agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3341294", "l": "Superoxide reduces cytochrome c (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218812", "l": "FYN phosphorylates PAK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362427", "l": "Hh-Np binds GPC5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004590", "l": "orotidine-5'-phosphate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44422", "l": "a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617179", "l": "PRKACA phosphorylates TNNI3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32678", "l": "alpha,alpha-trehalose + H2O <=> alpha-D-glucose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6804099", "l": "HMGB1 binds LTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46126", "l": "(24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53184", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47995", "l": "H(+)(in) + NAD(+) + NADPH <=> H(+)(out) + NADH + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20084", "l": "H2O + N-methylhexanamide <=> hexanoate + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61268", "l": "H2O + L-2-aminohexanoate + O2 = 2-oxohexanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016621", "l": "cinnamoyl-CoA reductase activity", "d": ["Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63876", "l": "2-oxoglutarate + 3(1)-hydroxy-L-isoleucine + O2 = (4S)-3(1),4-dihydroxy-L-isoleucine + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.75", "l": "\"3(1)-hydroxy-L-isoleucine 4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034889", "l": "endosulfan hemisulfate sulfatase activity", "d": ["Catalysis of the reaction: endosulfan hemisulfate + H2O = endosulfan monoalcohol + 2 H+ + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.84", "l": "\"limulus clotting factor C\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201457", "l": "BMP2 binds to the receptor complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55725", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24113", "l": "2 glutathione + O2 => glutathione disulfide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13849", "l": "D-arabinose = D-ribulose", "d": [], "t": []}, {"i": "EC:5.3.1.3", "l": "\"D-arabinose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29252", "l": "2 H(+)(out) + Na(+)(in) => 2 H(+)(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26003", "l": "D-arabinitol 1-phosphate + NAD(+) => D-xylulose 5-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008684", "l": "2-oxopent-4-enoate hydratase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416562", "l": "p190RhoGAP binds Plexin-B1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73943", "l": "dehydrogriseofulvin + H(+) + NADPH = griseofulvin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75846", "l": "ergothioneine(out) + Na(+)(out) <=> ergothioneine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68295", "l": "L-seryl-[protein] + nonanoyl-CoA <=> CoA + O-nonanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77392", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6S-D-GlcNAc + CMP-N-acetyl-beta-neuraminate => alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6S-D-GlcNAc + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78671", "l": "(3R)-3-hydroxydodecanoyl-CoA + NAD(+) = 3-oxododecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35872", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5633040", "l": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68723", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2533950", "l": "Fibronectin degradation by MMP14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0016636", "l": "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein."], "t": []}, {"i": "EC:1.3.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52310", "l": "2-oxoglutarate + H(+) + NADPH => 2-hydroxyglutarate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102564", "l": "aurachin C epoxide hydrolase/isomerase activity", "d": ["Catalysis of the reaction: aurachin C epoxide + H+ + NAD(P)H = aurachin B + H2O + NAD(P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210780", "l": "PDX1-dependent synthesis of NKX6-1 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62094", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68863", "l": "7-oxo-25-hydroxycholesterol + H(+) + NADPH <=> 7beta-25-dihydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018737", "l": "2-ketocyclohexane-1-carboxyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32525", "l": "beta-D-glucose 1-phosphate + D-glucose => nigerose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71702", "l": "H(+)(out) + L-phenylalanyl-L-leucine(out) <=> H(+)(in) + L-phenylalanyl-L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046990", "l": "N-hydroxyarylamine O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784189", "l": "JAKs bind LIFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64577", "l": "2 Fe(III)-[cytochrome b5] + NADPH => 2 Fe(II)-[cytochrome b5] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5483238", "l": "Hh processing variants are ubiquitinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25438", "l": "(E,R)-alpha-bisabolene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72880", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate => NH4(+) + phosphonoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38436", "l": "(9Z)-octadecenoyl-CoA + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54445", "l": "a (2R,3S,4S)-leucoanthocyanidin + NADP(+) => a (2R,3R)-dihydroflavonol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41086", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42548", "l": "uridine(746) in 23S rRNA = pseudouridine(746) in 23S rRNA", "d": [], "t": []}, {"i": "EC:5.4.99.29", "l": "\"23S rRNA pseudouridine(746) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015155", "l": "lactose transmembrane transporter activity", "d": ["Enables the transfer of lactose from one side of a membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33526", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O <=> acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450387", "l": "HuR binds the CRM1 nuclear export machinery (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67479", "l": "dimethylallyl diphosphate + L-glutamate <=> diphosphate + prekainate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11098", "l": "dihydroxyacetone phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482976", "l": "CDP-DAG is converted to PI by CDIPT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.-", "l": "\"Hydroxylases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36726", "l": "2-phenylethylamine + A + H2O <=> 2-phenylacetaldehyde + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15264", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821486", "l": "HCFC1 binds SET1A complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0000992", "l": "RNA polymerase III cis-regulatory region sequence-specific DNA binding", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9659820", "l": "RB1 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27765", "l": "CTP + H2O <=> CMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41979", "l": "a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GQ1balpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641134", "l": "SMURF2 binds AXIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1667005", "l": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446364", "l": "Migfilin interacts with VASP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683792", "l": "p-T68-CHEK2 autophosphorylates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218905", "l": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65491", "l": "3 ATP <=> 2',3',3'-c-tri-AMP + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35166", "l": "H(+)(out) + minocycline(in) <=> H(+)(in) + minocycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47109", "l": "cholate + taurine => H2O + taurocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9659820", "l": "RB1 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030411", "l": "scytalone dehydratase activity", "d": ["Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003866", "l": "3-phosphoshikimate 1-carboxyvinyltransferase activity", "d": ["Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160152", "l": "tRNA pseudouridine(31) synthase activity", "d": ["Catalysis of the reaction: uridine(31) in tRNA = pseudouridine(31) in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050452", "l": "CoA-glutathione reductase (NADPH) activity", "d": ["Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18268", "l": "6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) <=> 6-oxocyclohex-1-ene-1-carbonyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6801250", "l": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034520", "l": "2-naphthaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18825", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose = [(1->6)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31177", "l": "(S)-3-hydroxyisobutanoyl-CoA => (2E)-2-methylpropenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15047", "l": "H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH => N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419166", "l": "GEFs activate RhoA,B,C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027632", "l": "5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33042", "l": "4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin <=> 2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392870", "l": "Gs activation by prostacyclin receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55296", "l": "13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43708", "l": "ATP + H(+) + hexadecanoate = diphosphate + hexadecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-451418", "l": "Pellino ubiquitinates IRAK1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69888", "l": "Na(+)(out) + uridine(out) => Na(+)(in) + uridine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-378956", "l": "Luteinizing hormone is a heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17796", "l": "H2O + L-alanyl-tRNA(Thr) <=> H(+) + L-alanine + tRNA(Thr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32995", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.n7", "l": "\"1-acylglycerophosphoethanolamine O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670014", "l": "Factor VIIIa dissociates  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939204", "l": "ESTG binds ESR1:chaperone complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19850", "l": "H2O + NADP(+) => ADP-D-ribose 2'-phosphate + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20541", "l": "H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 = 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517674", "l": "p-S158,221-HuR binds mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29528", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202325", "l": "Recruitment of Gads to LAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52745", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + H2O => alpha-isomaltosyl-(1->3)-isomaltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22098", "l": "a ribonucleoside 5'-diphosphate + RNA(n) => phosphate + RNA(n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58088", "l": "1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O = (7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45963", "l": "24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32130", "l": "2-oxoglutarate + L-proline + O2 <=> cis-4-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55923", "l": "[cis-1,4-isoprene](n) + O2 <=> (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102792", "l": "sinapaldehyde:NAD(P)+ oxidoreductase activity", "d": ["Catalysis of the reaction: sinapoyl aldehyde + NADP + H2O = 2 H+ + trans-sinapate + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52647", "l": "D-xylono-1,4-lactone 5-phosphate + H2O <=> 5-phospho-D-xylonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76619", "l": "(6E)-8-methylnon-6-enoyl-CoA + 4-hydroxy-3-methoxy-benzenemethanol = capsiate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13892", "l": "FAD + H2O <=> AMP + FMN + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139899", "l": "Sequestration of BAD protein by 14-3-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40259", "l": "(2E)-hexadecenedioyl-CoA + H2O = (3S)-hydroxyhexadecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9674529", "l": "AAMP binds to TBXA2R (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114254", "l": "CYCS binds to APAF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32633", "l": "erythromycin C + H2O + NADP(+) => erythromycin D + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68227", "l": "2-oxoglutarate + H(+) + O2 + prekainate <=> CO2 + H2O + kainate lactone + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102838", "l": "1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029459", "l": "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212380", "l": "Formation of TRAP coactivator complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671993", "l": "CIT-3 binds DLG4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69144", "l": "Removal of RNA primer and dissociation of RPA and Dna2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15228", "l": "alpha-D-glucose 1-phosphate + dTTP + H(+) <=> diphosphate + dTDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9695890", "l": "SPNS2,MFSD2B transport S1P from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156923", "l": "Hydrolysis of eEF1A:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21338", "l": "4-pyridoxolactone + H(+) + NADH => NAD(+) + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70606", "l": "4-hydroxystyrene + H(+) + NADH <=> 4-ethylphenol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420739", "l": "GPRC6A can bind L-alpha amino acids and calcium (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38021", "l": "1-decanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-decanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018479", "l": "benzaldehyde dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65580", "l": "H2O + TTP = H(+) + phosphate + TDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663194", "l": "Some pathogenic BRCA1 mutants do not bind BARD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75259", "l": "isoorientin + O2 = 3''-dehydroisoorientin + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5622129", "l": "FABP5 binds atRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23958", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22960", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] = calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.88", "l": "\"isoflavone 3'-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47502", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => cholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050825", "l": "ice binding", "d": ["Binding to ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662908", "l": "Dopaquinone, cysteine form CD isomers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34207", "l": "3-O-alpha-D-glucosyl-L-rhamnose + phosphate = beta-D-glucose 1-phosphate + L-rhamnopyranose", "d": [], "t": []}, {"i": "EC:2.4.1.282", "l": "\"3-O-alpha-D-glucosyl-L-rhamnose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380272", "l": "Plk1-mediated phosphorylation of Nlp (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13251", "l": "2-oxopropyl-coenzyme M + H(+) + NADH => (R)-2-hydroxypropyl-coenzyme M + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68315", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O <=> 1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029476", "l": "Role of myosins in phagosome formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12026", "l": "D-glucose + O-sinapoylcholine => 1-O-(trans-sinapoyl)-beta-D-glucose + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250217", "l": "ARL2:GTP binds ARL2BP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50747", "l": "2 glyphosate + O2 <=> 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67492", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78245", "l": "2-oxosuccinamate + H2O2 + NH4(+) => D-asparagine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62226", "l": "(E)-ascladiol + NADP(+) => H(+) + NADPH + neopatulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848077", "l": "PTK6 phosphorylates STAP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35023", "l": "hydroquinone O-beta-D-glucopyranoside(out) = hydroquinone O-beta-D-glucopyranoside(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253319", "l": "ERBB4s80:TAB2:NCOR1 complex translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58570", "l": "CoA + O-acetyl-15alpha-stemmadenine => 15alpha-stemmadenine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54448", "l": "an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.29", "l": "\"peptidyl-tRNA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67182", "l": "ADP + glycyl-L-glutamyl-[protein] + H(+) + phosphate => ATP + glycine + L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-447226", "l": "Interleukin-12 binds Interleukin-12 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30674", "l": "H2O + N,N'-diacetylchitobiose <=> 2 N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72957", "l": "2 Na(+)(in) + nicotinate(in) => 2 Na(+)(out) + nicotinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15653", "l": "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.105", "l": "\"6-phosphofructo-2-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863494", "l": "ASICs bind STOML3, (STOM) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52732", "l": "3'-phosphoadenylyl sulfate + an 11-hydroxyjasmonate = adenosine 3',5'-bisphosphate + an 11-sulfojasmonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012556", "l": "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62255", "l": "2 hydrogencarbonate(out) + Zn(2+)(out) <=> 2 hydrogencarbonate(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985201", "l": "ABCE1 binds RNASEL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190256", "l": "FGFR1c binds to FGF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61855", "l": "campesterol + UDP-alpha-D-glucose <=> campesteryl 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870465", "l": "RGGT binds the RAB-binding subunit (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050527", "l": "poly(3-hydroxyoctanoate) depolymerase activity", "d": ["Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x is 1-5."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42446", "l": "H(+) + iminosuccinate + NADPH => L-aspartate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562526", "l": "PLK1 phosphorylates OPTN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047173", "l": "phosphatidylcholine-retinol O-acyltransferase activity", "d": ["Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44377", "l": "a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) => a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785607", "l": "FANCM binds FAAP24 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18829", "l": "4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.290", "l": "\"4-phosphoerythronate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59022", "l": "(9Z,12Z)-octadecadienoate + di-(9Z,12Z)-octadecadienoylglycerol + H(+) => 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56656", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15793", "l": "(4Z,15Z)-bilirubin IXalpha + NADP(+) = biliverdin IXalpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12142", "l": "a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+) => a 2'-deoxyribonucleoside + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31713", "l": "11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11553", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H2O => 1-O-alkyl-sn-glycerol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32903", "l": "calciol + O2 + reduced [NADPH--hemoprotein reductase] = calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.24", "l": "\"vitamin D 25-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67004", "l": "a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.74", "l": "\"mRNA 5'-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164527", "l": "Annealing of 3'-end of unwound transfer RNA primer with genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8865107", "l": "MICAL1 produces NADP+, H2O2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200646", "l": "Cytosolic folate export across the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047050", "l": "(S)-2-hydroxy-fatty acid dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxystearate + NAD+ = 2-oxostearate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757954", "l": "N4BP1 binds IKBKG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035299", "l": "inositol pentakisphosphate 2-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730882", "l": "Phosphorylation of PKC-theta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030020", "l": "extracellular matrix structural constituent conferring tensile strength", "d": ["A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0043138", "l": "3'-5' DNA helicase activity", "d": ["Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8979071", "l": "KDM6B binds iron (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804099", "l": "HMGB1 binds LTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629918", "l": "NEIL1 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938815", "l": "RNF152 polyubiquitinates RRAGA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20491", "l": "1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53101", "l": "2-hydroxyestrone + S-adenosyl-L-methionine => 2-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10657", "l": "guanidinoacetate + S-adenosyl-L-methionine => creatine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31164", "l": "(3S)-hydroxyhexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13422", "l": "an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate => an N-acylneuraminate 9-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62625", "l": "[glutaredoxin]-dithiol + a hydroperoxide => [glutaredoxin]-disulfide + an alcohol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53452", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30800", "l": "(3S)-3-hydroxybutanoyl-CoA + NAD(+) => acetoacetyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32685", "l": "2,5-dicarboxyfuran + 2 H(+) + 3 H2O2 => 5-hydroxymethylfurfural + 2 H2O + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15681", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) = (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.60", "l": "\"5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.1", "l": "\"transketolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32208", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate => (3Z)-2-oxohex-3-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67306", "l": "H2O2 + myceliothermophin E => 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32435", "l": "dihydrocarvone + H(+) + NADPH + O2 = 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42983", "l": "L-tyrosine <=> 2-aminoprop-2-enoate + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60708", "l": "(1R,3R)-chrysanthemal + H2O + NAD(+) = (1R,3R)-chrysanthemate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70038", "l": "6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428696", "l": "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381644", "l": "ER calcium channels open in response to activated PKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21245", "l": "an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine => an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14597", "l": "a CDP-1,2-diacyl-sn-glycerol + choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.24", "l": "\"phosphatidylcholine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76558", "l": "ergosterol + L-aspartyl-tRNA(Asp) <=> 1-(ergostan-3beta-yl)-L-aspartate + tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72353", "l": "glutarate(out) + glycocholate(in) => glutarate(in) + glycocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40685", "l": "1-O-dodecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + dodecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878054", "l": "HIPK2 phosphorylates RUNX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67008", "l": "a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.56", "l": "\"mRNA (guanine-N(7))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25916", "l": "A + H2O + quinolin-6-ol = 6-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656070", "l": "FGFBPs bind FGFs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626270", "l": "Defective SLC24A4 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9793485", "l": "PRKN polyubiquitinates RIPK3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732629", "l": "PPARG binds PPARG agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63307", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19935", "l": "D-glucose + phosphate => alpha-D-glucose 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24116", "l": "(2E)-geranyl diphosphate + H2O = (S)-linalool + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.25", "l": "\"S-linalool synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39698", "l": "3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH <=> (R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432010", "l": "Aquaporin-1 passively transports water into cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74246", "l": "H2O + L-alanyl-tRNA(Pro) <=> H(+) + L-alanine + tRNA(Pro)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795460", "l": "SGK1 phosphorylates MDM2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56996", "l": "aldehydo-D-apiose = apulose", "d": [], "t": []}, {"i": "EC:5.3.1.36", "l": "\"D-apiose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045353", "l": "interleukin-1 type II receptor antagonist activity", "d": ["Blocks the binding of interleukin-1 to interleukin-1 type II receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56016", "l": "H2O + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047260", "l": "alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity", "d": ["Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74551", "l": "H2O + L-seryl-tRNA(Ser) = L-serine + tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73114", "l": "S-adenosyl-L-methionine + scutellarein 4'-methyl ether <=> ladanein + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48606", "l": "2,3-dihydroxybenzoyl-[ACP] + AMP + H(+) => 2,3-dihydroxybenzoyl-5'-AMP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951586", "l": "p-VAV family:PIP3 binds RAC1:GDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15164", "l": "4-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805785", "l": "AKT phosphorylates PHF20 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36984", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673296", "l": "WNT5:FZD7 binds p-DVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10459", "l": "acetyl-CoA + D-maltose <=> 1-O-acetylmaltose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983307", "l": "IL15 binds IL15RA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41149", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66709", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696547", "l": "STAMBPL1 is a deubiquitinase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55591", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036127", "l": "3-sulfino-L-alanine binding", "d": ["Binding to 3-sulfino-L-alanine (cysteine sulfinate)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047310", "l": "glutamine-scyllo-inositol transaminase activity", "d": ["Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9695890", "l": "SPNS2,MFSD2B transport S1P from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805785", "l": "AKT phosphorylates PHF20 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847995", "l": "Activated ERBB2 binds PTK6 (BRK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39332", "l": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64999", "l": "ATP + H(+) + octanoate <=> diphosphate + octanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60986", "l": "16-oxohexadecanoate + H(+) + NADH => 16-hydroxyhexadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44404", "l": "3-demethylubiquinol-7 + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + ubiquinol-7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9728150", "l": "SLC5A2 binds gliflozins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362553", "l": "NOTUM releases Hh-Np:GPC5 from the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111970", "l": "PKC phosphorylates GRK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683669", "l": "E protein gets N-glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23688", "l": "adenine + H(+) + H2O = hypoxanthine + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.2", "l": "\"adenine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19110", "l": "1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose => 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004588", "l": "orotate phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37574", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.70", "l": "\"pancreatic endopeptidase E\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981355", "l": "RASA1 binds RAS:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57265", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP => GDP + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56765", "l": "12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 => 12-epi-fischerindole G + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050797", "l": "thymidylate synthase (FAD) activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63972", "l": "A + dihydropyriculol = AH2 + pyriculol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49364", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) = 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203611", "l": "N-myristoylation of eNOS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070611", "l": "histone H3R2 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to the arginine residue at position 2 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391934", "l": "DP2 receptor can bind PGD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001002", "l": "RNA polymerase III type 1 promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35666", "l": "a 1,2-diacyl-sn-glycerol + H2O <=> a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60170", "l": "a fatty acyl phosphate + ADP => a fatty acid + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042012", "l": "interleukin-16 receptor activity", "d": ["Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430308", "l": "PARVB interacts with Alpha-actinin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163691", "l": "Phosphorylation of ChREBP at Serine 556 by AMPK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11535", "l": "glycine + H2O + O2 <=> glyoxylate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693575", "l": "DNA-PKcs autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58458", "l": "(R)-glycerate + D-mannose => (2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27430", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1,2-diacyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41678", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814670", "l": "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26483", "l": "adenosine(37) in tRNA + dimethylallyl diphosphate => diphosphate + N(6)-dimethylallyladenosine(37) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17363", "l": "H(+) + malonate + urea => 3-oxo-3-ureidopropanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15472", "l": "1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide <=> 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24384", "l": "ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)", "d": [], "t": []}, {"i": "EC:6.3.5.1", "l": "\"NAD(+) synthase (glutamine-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953037", "l": "E2F8 forms homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033908", "l": "beta-L-rhamnosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48799", "l": "O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33248", "l": "O2 + putrescine => 1-pyrroline + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29633", "l": "alpha-D-glucose + D-maltotriose => D-maltotetraose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13344", "l": "a menaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + an 8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68163", "l": "N-geranyl-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66356", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) = (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30023", "l": "L-alanine + pyridoxal 5'-phosphate = pyridoxamine 5'-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48617", "l": "H2O + leukotriene D4 => glycine + leukotriene E4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43871", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) <=> a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70852", "l": "H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) => H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4827383", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20379", "l": "5alpha-androstan-3,17-dione + H(+) + NADPH => androsterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030565", "l": "snRNA pseudouridylation guide activity", "d": ["Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21031", "l": "acetyl-CoA + an N-terminal L-alpha-aminoacyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alpha-aminoacyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33666", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39568", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2473184", "l": "Follistatin (FST) binds Activin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43602", "l": "3R-hydroxyeicosanoyl-[ACP] + NADP(+) => 3-oxoeicosanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47340", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46788", "l": "a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.92", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38733", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45119", "l": "(4R)-ipsdienol + NADP(+) <=> H(+) + ipsdienone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2512800", "l": "SCARB1:ligand is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27451", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate => a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9859163", "l": "DBT transfers BCAA to CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31712", "l": "beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63756", "l": "flavokermesate + UDP-alpha-D-glucose = flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69422", "l": "H2O + hypoiodite => H2O2 + iodide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43179", "l": "cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951644", "l": "Release of mature NEDD8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64033", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP-beta-L-fucose => a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717841", "l": "holo-FDPS dimer binds NBPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62020", "l": "H2O + sitosteryl 3-beta-D-glucoside = D-glucose + sitosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27565", "l": "all-trans-nonaprenyl diphosphate + 7 diphosphate => (2E)-geranyl diphosphate + 7 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177942", "l": "EGFR binds EGF ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938913", "l": "RUNX1 binds ELF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20994", "l": "16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine => 16-hydroxytabersonine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983425", "l": "Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18176", "l": "(R)-octopamine <=> (4-hydroxyphenyl)acetaldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56841", "l": "5-amino-2-hydroxybenzoate + O2 => (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55225", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17024", "l": "(2-aminoethyl)phosphonate + pyruvate <=> L-alanine + phosphonoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29383", "l": "dIMP + H2O = 2'-deoxyinosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38879", "l": "a fatty acid(in) = a fatty acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60054", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+) => a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18509", "l": "H(+) + H2O2 + NADH = 2 H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.11.1.1", "l": "\"NADH peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352268", "l": "Cleavage of Satb1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24242", "l": "adenosine 5'-phosphosulfate + AH2 => A + AMP + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693250", "l": "RHOD binds effectors at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18786", "l": "A + gibberellin A12 aldehyde + H2O => AH2 + gibberellin A12 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69257", "l": "H2O + progoitrin => (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334827", "l": "SUMO-CRABP2 binds atRA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177934", "l": "EGFR autophosphorylation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204169", "l": "PDP1,2 dephosphorylate p-lipo-PDH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689111", "l": "PARK2 autoubiquitinates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57810", "l": "3-chlorocatechol + NAD(+) + nitrite => 1-chloro-3-nitrobenzene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54310", "l": "H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39432", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33854", "l": "GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) <=> GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633441", "l": "TP53 stimulates transcription of TNFRSF10A, TNFRSF10B,TNFRSF10C and TNFRSF10D genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53215", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta,18-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58052", "l": "(2-aminoethyl)phosphonate + acetyl-CoA = (2-acetamidoethyl)phosphonate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74780", "l": "laricitrin + S-adenosyl-L-methionine => 3,3'-O-dimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18063", "l": "methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin => 5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30555", "l": "GTP + L-glutamate + oxidized coenzyme F420-0 = GDP + H(+) + oxidized coenzyme F420-1 + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.31", "l": "\"coenzyme F420-0:L-glutamate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9825754", "l": "HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617829", "l": "Assembly of IFT A complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653514", "l": "USP17L2 deubiquitinates RCE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52765", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O => (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823989", "l": "Expression of FOXA2 in definitive endoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59523", "l": "ATP + butanoyl-CoA + hydrogencarbonate <=> (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3249378", "l": "STING recruits TBK1 and STAT6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31091", "l": "acetyl-CoA + dodecanoyl-CoA = 3-oxotetradecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67729", "l": "DNA(n) + dZTP => diphosphate + DNA(n)-Z", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53519", "l": "1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875591", "l": "DOCK7 activates RAC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45008", "l": "H2O + N-(octadecanoyl)-sphinganine = octadecanoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21781", "l": "A + cyclohexanone => AH2 + cyclohex-2-enone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41249", "l": "9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448728", "l": "IL19 binds IL20RA:JAK1:IL20RB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821412", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018129", "l": "peptidyl-oxazoline dehydrogenase activity", "d": ["Catalysis of the reduction of a peptide-linked oxazoline to oxazole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937177", "l": "AHR:TCDD binds ARNT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507870", "l": "Aquaporins passively transport water out of cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389354", "l": "Activation of Vav1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42218", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16995", "l": "6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => 6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33416", "l": "bornane-2,6-dione + H2O => [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.125", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64073", "l": "acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA => 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76273", "l": "N,N-dimethylglycine(out) => N,N-dimethylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48851", "l": "(9Z,12Z)-octadecadienoate + O2 <=> 13-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34331", "l": "H(+) + indole-3-pyruvate + NADPH + O2 = (indol-3-yl)acetate + CO2 + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.168", "l": "\"indole-3-pyruvate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33687", "l": "3'-N-debenzoyltaxol + benzoyl-CoA = CoA + H(+) + taxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799777", "l": "TP53 family members bind PPP1R13B or TP53BP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4411402", "l": "Activation of NLK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944266", "l": "Association of procollagen type XI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866269", "l": "ARRB bind GPCRs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74351", "l": "2 (S)-lactate(in) + prostaglandin E3(out) = 2 (S)-lactate(out) + prostaglandin E3(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15279", "l": "CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin] => acetyl-CoA + L-lysyl-[alpha-tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956676", "l": "YAP1 binds TP73 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016223", "l": "beta-alanine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928597", "l": "EPH:EFN dimers tetramerise (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66129", "l": "2-oxobutanoate + L-phenylalanine => (2S)-2-aminobutanoate + 3-phenylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0005295", "l": "neutral L-amino acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) = neutral L-amino acid(in) + Na+(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40465", "l": "(9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+) => 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120091", "l": "jasmonic acid hydrolase", "d": ["Catalyzes the hydroxylation of jasmonic acid to 12OH-jasmonic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9866253", "l": "apo-UQCRFS1 binds LYRM7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31171", "l": "(3S)-hydroxytetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44499", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine <=> 2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55695", "l": "an inositol-1-phosphoceramide + H2O <=> 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76865", "l": "benzaldehyde + H(+) + NADH + NH4(+) => benzylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70613", "l": "GOT2 transaminates OA and L-Glu (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51405", "l": "H2O + L-arginine + O2 => 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676229", "l": "WIPIs bind PI3P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70851", "l": "H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) = H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156907", "l": "Aminoacyl-tRNA  binds to the ribosome at the A-site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757438", "l": "ASA- translocates from cytosol to ER lumen of GI cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36646", "l": "emodin + S-adenosyl-L-methionine <=> H(+) + questin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9861631", "l": "ME1 tetramerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49631", "l": "acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine <=> 3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16359", "l": "AH2 + fumarate => A + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21741", "l": "2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol => [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31695", "l": "(9Z,12Z)-octadecadienoate + O2 = (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": [], "t": []}, {"i": "EC:1.13.11.62", "l": "\"linoleate 10R-lipoxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70510", "l": "LDH tetramer oxidises LACT to PYR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69068", "l": "RFC dissociates after sliding clamp formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140826", "l": "zinc:proton antiporter activity", "d": ["Enables the transfer of zinc from one side of a membrane to the other according to the reaction: H+(out) + Zn2+(in) = H+(in) + Zn2+(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202713", "l": "CD84 homodimerises (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57156", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 = 4-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015591", "l": "D-ribose transmembrane transporter activity", "d": ["Enables the transfer of D-ribose from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59526", "l": "9-O-10-oxo-(12Z)-octadecenoate L-aspartatyl ester-[protein] => 9S,10-epoxy-(10,12Z)-octadecadienoate + H(+) + L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035241", "l": "protein-arginine omega-N monomethyltransferase activity", "d": ["Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033796", "l": "sulfur reductase activity", "d": ["Catalysis of the reduction of elemental sulfur or polysulfide to hydrogen sulfide, H2 + n sulfur = H+ + hydrogen sulfide + (n-1) sulfur."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-909552", "l": "Phosphorylation of STAT1 at Ser727 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73239", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether = H(+) + ladanein + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396399", "l": "Fibrillins bind BMPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32466", "l": "glycine + 2 S-adenosyl-L-methionine <=> 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045521", "l": "interleukin-25 receptor binding", "d": ["Binding to an interleukin-25 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21208", "l": "H2O + O-phospho-L-serine = L-serine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8934446", "l": "Activated PKC phosphorylates SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830284", "l": "Protein M2-1 tetramers bind protein P tetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78905", "l": "a medium-chain 3-oxoacyl-CoA + CoA => a medium-chain fatty acyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16958", "l": "3',5'-cyclic GMP + H2O => GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53108", "l": "2-hydroxyestrone + S-adenosyl-L-methionine = 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70630", "l": "H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031731", "l": "CCR6 chemokine receptor binding", "d": ["Binding to a CCR6 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65435", "l": "a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate <=> a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102369", "l": "11alpha-30-dihydroxy beta-amyrin dehydrogenase activity", "d": ["Catalysis of the reaction: 11alpha,30-dihydroxy-beta-amyrin + NADPH + O2 + H+ = 30-hydroxy-11-oxo-beta-amyrin + NADP + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9749253", "l": "Formation of MCM2-7 complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209823", "l": "Tyrosine is hydroxylated to dopa (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:1903763", "l": "gap junction channel activity involved in cell communication by electrical coupling", "d": ["Any gap junction channel activity that is involved in cell communication by electrical coupling."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950782", "l": "p-STAT1 binds p-STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47977", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31518", "l": "4'-apo-beta-carotenal + H2O + NAD(+) <=> 2 H(+) + NADH + neurosporaxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66676", "l": "(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide = 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719354", "l": "Defective DPM3 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9838081", "l": "LONP1 degrades mitochondrial matrix proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21196", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45637", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69709", "l": "beta-D-galactose + N-hexadecanoylsphinganine => beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20141", "l": "an S-alkyl-L-cysteine S-oxide = 2-aminoprop-2-enoate + an S-alkyl sulfenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448728", "l": "IL19 binds IL20RA:JAK1:IL20RB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17216", "l": "UDP-N-acetyl-alpha-D-glucosamine <=> UDP-N-acetyl-alpha-D-mannosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653514", "l": "USP17L2 deubiquitinates RCE1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67091", "l": "ATP + H2O + tetracosanoate(in) <=> ADP + H(+) + phosphate + tetracosanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49381", "l": "5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112037", "l": "Inactivation of PLC beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56986", "l": "(6E)-nerolidol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.9.-", "l": "\"With a copper protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170978", "l": "p-FRS2:CRKL binds C3G (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59156", "l": "ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54745", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70930", "l": "(R)-glycerate(in) + H(+)(in) <=> (R)-glycerate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417898", "l": "P2Y4 receptor can bind to UTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68489", "l": "(2R)-2-hydroperoxytetradecanoate + H(+) => CO2 + H2O + tridecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762097", "l": "MYC binds the NFE2L2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171059", "l": "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34082", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + ADP + H(+) <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001073", "l": "transcription antitermination factor activity, DNA binding", "d": ["Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2730872", "l": "Activation of Calcineurin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69100", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873921", "l": "Binding of STAT1 to p-IFNGR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65272", "l": "chrodrimanin C + H(+) + NADPH + O2 = chrodrimanin H + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47100", "l": "choloyl-CoA + taurine = CoA + H(+) + taurocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20522", "l": "(R)-3-hydroxybutanoate + NAD(+) => acetoacetate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450088", "l": "GLUT1 tetramer binds 4xATP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34499", "l": "1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin] = H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate", "d": [], "t": []}, {"i": "EC:1.14.15.11", "l": "\"pentalenic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018769", "l": "2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38632", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74885", "l": "GUCYs converts GTP to cGMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49195", "l": "calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23968", "l": "(E)-coniferaldehyde + H2O + NAD(+) = (E)-ferulate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "51.532112063283655", "identifiers": [{"i": "GO:0005261", "l": "monoatomic cation channel activity", "d": ["Enables the energy-independent facilitated diffusion of a monoatomic cation through a transmembrane aqueous pore or channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17411", "l": "(S)-N-methylcoclaurine + H(+) + S-adenosyl-L-homocysteine => (S)-coclaurine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47737", "l": "cytidine(1404) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1404) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:1904091", "l": "non-ribosomal peptide synthetase activity", "d": ["Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186765", "l": "PLC-gamma binds to the active receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76202", "l": "oxalate(in) <=> oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875531", "l": "MET binds TNS4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30986", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] <=> beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210912", "l": "Furin cleaves ANTXR2-bound pagA to yield pagA(197-794) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77077", "l": "Capping complex formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-114284", "l": "Release of Cytochrome c from mitochondria (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39072", "l": "dodecanedioyl-CoA + O2 => (2E)-dodecenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31290", "l": "H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA <=> acryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004522", "l": "ribonuclease A activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0046982", "l": "protein heterodimerization activity", "d": ["Binding to a nonidentical protein to form a heterodimer."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9675026", "l": "Formation of the MLL1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59515", "l": "acetylsalicylate + L-seryl-[protein] <=> O-acetyl-L-seryl-[protein] + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38985", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+) => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47985", "l": "H2O + presqualene diphosphate => diphosphate + hydroxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174070", "l": "Association of Cdh1 with the APC/C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10939", "l": "6-decylubiquinone + 2 thiosulfate <=> 6-decylubiquinol + tetrathionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909720", "l": "IFN alpha/beta binds to IFNAR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18673", "l": "ATP + L-seryl-[receptor-protein] = ADP + H(+) + O-phospho-L-seryl-[receptor-protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35408", "l": "H2O + medicarpin => 4'-methoxyisoflavan-2',4,7-triol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692539", "l": "HRH1 binds HRH1 inverse agonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42491", "l": "(3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III <=> 3'-N-debenzoyl-2'-deoxytaxol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835189", "l": "NCK1 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1504188", "l": "FZD recruits DVL to the receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14478", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165027", "l": "Rev molecules assemble onto the RRE RNA sequence through their ARM sequence (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62239", "l": "a cytidine(6-4)cytidine in DNA <=> a cytidine dimer in DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34767", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O = (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62165", "l": "beta-D-glucosaminyl-(1->4)-N-acetyl-D-glucosamine + H2O => D-glucosamine + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35422", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> an anthocyanidin 3-O-sophoroside + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44152", "l": "1D-myo-inositol 2-phosphate + H2O = myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63716", "l": "losartan + UDP-alpha-D-glucuronate = losartan-1-N-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247839", "l": "Retromer associates with WLS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655702", "l": "Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64778", "l": "2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol => 3-sulfanylpentan-1-ol-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67500", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41111", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008526", "l": "phosphatidylinositol transfer activity", "d": ["Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41528", "l": "(2E)-octenoyl-[ACP] + H(+) + NADH = NAD(+) + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56024", "l": "H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70083", "l": "hydroxyclavatol = H2O + o-quinone methide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28369", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate <=> beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551661", "l": "PIAS4 SUMOylates RNF168 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29382", "l": "dGMP + H2O <=> 2'-deoxyguanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2038398", "l": "KIBRA (WWC1) binds LATS proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.58", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9688459", "l": "RIPK3 binds HSP90:CDC37 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014293", "l": "RAC2 GDIs block activation of RAC2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70554", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35940", "l": "brevianamide F + dimethylallyl diphosphate => diphosphate + tryprostatin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432010", "l": "Aquaporin-1 passively transports water into cell (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811508", "l": "ING2-bound EP300 acetylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41711", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20734", "l": "[protein]-disulfide + [thioredoxin]-dithiol => [protein]-dithiol + [thioredoxin]-disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.923250621671642", "identifiers": [{"i": "GO:0003916", "l": "DNA topoisomerase activity", "d": ["Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700156", "l": "Active ALK dimer binds IRS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852317", "l": "PLK1 phosphorylates GTSE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57366", "l": "(6S)-NADHX => H2O + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67101", "l": "fumigatonoid B => fumigatonoid C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65478", "l": "CoA + propyl butanoate => 1-propanol + butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627078", "l": "XIAP binds CASP9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852331", "l": "GTSE1 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102179", "l": "24-ethylidenelophenol 4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 24-ethylidenelophenol + NADH + O2 + H+ = 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73500", "l": "3',4',7-trihydroxyflavone + S-adenosyl-L-methionine => 4',7-dihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66554", "l": "5-serotonyl-L-glutamyl-[protein] + NH4(+) => L-glutaminyl-[protein] + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.374", "l": "\"2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42400", "l": "lactose(out) + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + lactose 6-phosphate(in)", "d": [], "t": []}, {"i": "EC:2.7.1.207", "l": "\"protein-N(pi)-phosphohistidine--lactose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48831", "l": "H(+) + NADPH + O2 + resorcinol <=> benzene-1,2,4-triol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031715", "l": "C5L2 anaphylatoxin chemotactic receptor binding", "d": ["Binding to a C5L2 anaphylatoxin chemotactic receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49210", "l": "20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448728", "l": "IL19 binds IL20RA:JAK1:IL20RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0023024", "l": "MHC class I protein complex binding", "d": ["Binding to a class I major histocompatibility complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034542", "l": "trimethylarsine oxidase activity", "d": ["Catalysis of the reaction: trimethylarsine oxide + 2 H+ + 2 e- = trimethylarsine + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77103", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851888", "l": "MET binds SHC1-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613210", "l": "EGR1, EGR2 bind the RRAD promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25041", "l": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + 2 phosphate", "d": [], "t": []}, {"i": "EC:2.9.1.2", "l": "\"O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660514", "l": "MTF1 dimer:12Zn2+ binds CSRP1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9658253", "l": "RAS:GTP binds PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66922", "l": "(2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate => 6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0015666", "l": "restriction endodeoxyribonuclease activity", "d": ["Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50476", "l": "anthraniloyl-CoA + L-cysteinyl-[PqsD protein] = CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2065539", "l": "SREBP1A,1C,2:Importin beta-1 dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22086", "l": "2 NH4(+) + pyruvate => (S)-2,3-diaminopropanoate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14414", "l": "biphenyl-2,3-diol + O2 => 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76284", "l": "guanine(out) + Na(+)(out) => guanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981648", "l": "C4b binding protein binds C4bC2a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805035", "l": "TP53 binds STK11 and NUAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77107", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52319", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341072", "l": "SUMOylation of RARA with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14723", "l": "H(+) + O-beta-D-xylosylzeatin + UDP => UDP-alpha-D-xylose + zeatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641155", "l": "DVL1 is bound by the HECT ubiquitin ligase HECW1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9838035", "l": "CLPXP binds mitochondrial matrix proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629588", "l": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13424", "l": "an N-acyl-D-mannosamine 6-phosphate + H2O + phosphoenolpyruvate <=> an N-acylneuraminate 9-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654571", "l": "Activated FGFR1 binds FRS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45098", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-hexadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199456", "l": "PTEN dephosphorylates PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23208", "l": "acetyl-CoA + trans-glutaconate = (2E)-glutaconyl-CoA + acetate", "d": [], "t": []}, {"i": "EC:2.8.3.12", "l": "\"glutaconate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62939", "l": "H2O + N(4)-acetyl-2'-deoxycytidine <=> 2'-deoxycytidine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351913", "l": "Caspase-mediated cleavage of TJP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31367", "l": "2 H(+) + 3 nitrite = H2O + nitrate + 2 nitric oxide", "d": [], "t": []}, {"i": "EC:1.7.6.1", "l": "\"nitrite dismutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23002", "l": "(R)-4-dehydropantoate + H(+) + NADH => (R)-pantoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18784", "l": "H(+) + malonyl-CoA <=> acetyl-CoA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008902", "l": "hydroxymethylpyrimidine kinase activity", "d": ["Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75464", "l": "choline(out) + n H(+)(in) => choline(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0061135", "l": "endopeptidase regulator activity", "d": ["Binds to and modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901359", "l": "tungstate binding", "d": ["Binding to tungstate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38331", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109639", "l": "Formation of the closed pre-initiation complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20853", "l": "ATP + H(+)(in) + H2O => ADP + 2 H(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12708", "l": "[protein]-L-isoaspartate + S-adenosyl-L-methionine <=> [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66243", "l": "ATP + CoA + IC-asc-C9 <=> AMP + diphosphate + IC-asc-C9-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65534", "l": "2-methylbutyl hexanoate + CoA => 2-methylbutan-1-ol + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624494", "l": "RAF1 binds p21 RAS:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27543", "l": "methanol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78918", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA <=> a long-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004369", "l": "glycerol-3-phosphate oxidase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58346", "l": "D-glucose + lithocholate => beta-D-glucosyl-(1->3)-O-lithocholate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30191", "l": "15-cis-phytoene + plastoquinone-9 = 15,9'-di-cis-phytofluene + plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24512", "l": "L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.50", "l": "\"pyrazolylalanine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.87", "l": "\"malonyl-[malonate decarboxylase] decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9717841", "l": "holo-FDPS dimer binds NBPs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14087", "l": "5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate => (2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19627", "l": "acetaldehyde + glycine => L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25356", "l": "2-hydroxyphytanoyl-CoA => 2,6,10,14-tetramethylpentadecanal + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071535", "l": "RING-like zinc finger domain binding", "d": ["Binding to a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73334", "l": "(2R,3S)-piscidate + (E)-feruloyl-CoA <=> cimicifugate E + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620975", "l": "MLKL binds PIPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45961", "l": "24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33010", "l": "(+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50556", "l": "prostaglandin D2 = H2O + prostaglandin J2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72775", "l": "7-carboxymellein + ATP + L-phenylalanine = ADP + H(+) + ochratoxin B + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10781", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) => 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.28", "l": "\"L-cysteine desulfidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375384", "l": "Bombesin-like receptors bind bombesin homologues (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60732", "l": "H2O + NADP(+) + perillyl aldehyde = 2 H(+) + NADPH + perillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49230", "l": "diphosphate + geranylgeranyl-bacteriochlorophyllide a => (2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12415", "l": "(2R)-3-phosphoglycerate + H2O <=> (R)-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69614", "l": "H2O + kojibiose <=> beta-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38476", "l": "L-histidine + S-adenosyl-L-methionine => H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665699", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809707", "l": "MTMR12 binds MTMR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19545", "l": "H2O + sn-glycerol 3-phosphocholine = glycerol + H(+) + phosphocholine", "d": [], "t": []}, {"i": "EC:3.1.4.38", "l": "\"glycerophosphocholine cholinephosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35444", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-xylose => an anthocyanidin 3-O-beta-D-sambubioside + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982017", "l": "Active G alpha (q) binds RGS proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9647977", "l": "ICMT methylates S-Farn RAS proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48108", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.320", "l": "\"type II protein arginine methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65634", "l": "an N-tetracosanoyl-sphingoid base + CoA + H(+) => a sphingoid base + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728748", "l": "Bitter compound binds bitter taste receptor (TAS2R) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35807", "l": "2-dehydro-3-deoxy-D-arabinonate = 2,5-dioxopentanoate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.141", "l": "\"2-dehydro-3-deoxy-D-arabinonate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.70", "l": "\"7-deoxycylindrospermopsin hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37535", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000824", "l": "inositol tetrakisphosphate 3-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033900", "l": "ribonuclease F activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873946", "l": "OTUD3 deubiquitinates PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034548", "l": "N-cyclopropylammeline deaminase activity", "d": ["Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74573", "l": "N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl-[protein] => H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65551", "l": "a ganglioside Fuc-GM1 + H2O <=> alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52774", "l": "6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate => 7,8-dihydroneopterin 3'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60436", "l": "3-methylbutyl acetate + H2O = 3-methylbutanol + acetate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.112", "l": "\"isoamyl acetate esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14837", "l": "glyoxylate + H2O + O2 = H(+) + H2O2 + oxalate", "d": [], "t": []}, {"i": "EC:1.2.3.5", "l": "\"glyoxylate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37793", "l": "aclacinomycin Y + H2O2 => aclacinomycin A + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034011", "l": "L-cysteate sulfo-lyase activity", "d": ["Catalysis of the reaction: L-cysteate + H2O = NH4 + pyruvate + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37601", "l": "(9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O => (9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3782655", "l": "HDAC10 deacetylates histone (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33217", "l": "all-trans-heptaprenyl diphosphate + 3 diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445714", "l": "Aquaporin-3 passively transports water out of cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254285", "l": "ERBB4s80:STAT5A complex translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62677", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide => 6-thio-IMP + 7,8-dihydrofolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226964", "l": "ANKH transports PPi from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8981657", "l": "IL34 dimer binds PTPRZ1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8934735", "l": "PRMT1 arginine-methylates RUNX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190682", "l": "Connexin synthesis (generic) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675194", "l": "Activated MAPK phosphorylates RAF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026001", "l": "Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000319", "l": "BORA binds PLK1 and AURKA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70604", "l": "4-hydroxystyrene + H(+) + NADH => 4-ethylphenol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39599", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016492", "l": "G protein-coupled neurotensin receptor activity", "d": ["Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904121", "l": "phosphatidylethanolamine transfer activity", "d": ["Removes phosphatidylethanolamine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34398", "l": "L-phenylalanine <=> L-beta-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59960", "l": "N(alpha)-acetyl-D-methionine = N(alpha)-acetyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24550", "l": "a carboxylate + L-lysine => an N(6)-acyl-L-lysine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15532", "l": "bis(2-ethylhexyl)phthalate + H2O <=> 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088130", "l": "PLK1 binds FOXM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018556", "l": "2,2',3-trihydroxybiphenyl dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24851", "l": "3-dehydroshikimate <=> 3,4-dihydroxybenzoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804527", "l": "INTL1 binds bacterial glycans (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19564", "l": "androst-4-ene-3,17-dione + H(+) + NADPH + O2 <=> H2O + NADP(+) + testololactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25015", "l": "(E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507937", "l": "STAT5 dimers translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016287", "l": "glycerone-phosphate O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9606894", "l": "p-DAPP1 (p-BAM32) binds PLCG2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48509", "l": "cholate + NADP(+) => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75119", "l": "all-trans-13,14-dihydroretinal + H2O + NAD(+) = all-trans-13,14-dihydroretinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77936", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate => 1,3-di-(9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56372", "l": "3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2 = 3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54509", "l": "all-trans-heptaprenyl diphosphate => beta-heptaprene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9846305", "l": "ST6GALNAC5,6 transfer Neu5Ac to GM1b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9703895", "l": "CASR binds CASR agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73328", "l": "(2R,3S)-piscidate + (E)-sinapoyl-CoA => cimicifugate J + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797090", "l": "CCNK binds CDK12 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265301", "l": "Corticotropin cleavage from POMC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49226", "l": "dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin] => dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050529", "l": "polyneuridine-aldehyde esterase activity", "d": ["Catalysis of the reaction: H2O + polyneuridine aldehyde = 16-epivellosimine + CO2 + methanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52578", "l": "(2E)-hexenoyl-CoA + H(+) + NADH => hexanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52031", "l": "a jasmonyl-L-amino acid + H2O <=> a jasmonate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106223", "l": "germacrene A hydroxylase activity", "d": ["Catalysis of the reaction:(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15915", "l": "ADP + thiamine diphosphate => ATP + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201629", "l": "Caspase-mediated cleavage of Tau (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043237", "l": "laminin-1 binding", "d": ["Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66924", "l": "[(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA = [(R)-3-hydroxyalkanoate](n+1) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32076", "l": "geranylgeranyl diphosphate + H2O => (13E)-labda-7,13-dien-15-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606327", "l": "Phosphorylation and release of IRF3  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793921", "l": "Expression of DLL1 in paraxial mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807585", "l": "BPI binds LPS on the bacterial surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19541", "l": "L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.41", "l": "\"glutamate-5-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392748", "l": "L1 binds to AP-2 Clathrin complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36274", "l": "caffeine + H(+) + NADPH + O2 <=> formaldehyde + H2O + NADP(+) + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195275", "l": "Phosphorylation of APC component of the destruction complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786095", "l": "JAK1 phosphorylates STAT3,STAT6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191303", "l": "FDPS dimer transfers IPPP to GPP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69864", "l": "a uridine in mRNA + S-adenosyl-L-methionine => a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9690461", "l": "FKBP1A binds tacrolimus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42003", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> an isogloboside iGb3Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928578", "l": "EPH receptors autophosphorylate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416929", "l": "PTGFR binds PGF2a (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51162", "l": "5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102375", "l": "11-oxo-beta-amyrin 30-oxidase activity", "d": ["Catalysis of the reaction: 11-oxo-beta-amyrin + 3 NADPH + 3 O2 + 2 H+ = glycyrrhetinic acid + 3 NADP + 4 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18739", "l": "AMP + 2 H(+) + phosphate + selenophosphate => ATP + H2O + hydrogenselenide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031736", "l": "CCR11 chemokine receptor binding", "d": ["Binding to a CCR11 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783530", "l": "gp130:JAKs bind CNTFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.76", "l": "\"flavastacin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75753", "l": "10-hydroxyoctadecanoate => (9Z)-octadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0004693", "l": "cyclin-dependent protein serine/threonine kinase activity", "d": ["Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64355", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA <=> 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9672173", "l": "Autophosphorylation of PDGFRA extracellular domain dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72320", "l": "n chloride(in) + urate(out) => n chloride(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22910", "l": "3',5'-cyclic IMP + NH4(+) => 3',5'-cyclic AMP + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9824888", "l": "OPTN, TBK1 bind ubiquitinated MOM proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49862", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27270", "l": "CoA + hexadecanal + NADP(+) = H(+) + hexadecanoyl-CoA + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30850", "l": "FAD + glutaryl-CoA + 2 H(+) <=> (2E)-butenoyl-CoA + CO2 + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39087", "l": "decanedioyl-CoA + O2 = (2E)-decenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49872", "l": "(+)-dehydrodiconiferyl acid ketone + a quinone + H2O = (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199298", "l": "AKT phosphorylates CREB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78140", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => a 1,3-diacylglycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180006", "l": "RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine (consensus YSPTSPS)(position 2) + H2O = RNA polymerase II large subunit + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.13", "l": "\"(6-4)DNA photolyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18954", "l": "L-erythro-7,8-dihydrobiopterin + NADP(+) => H(+) + NADPH + sepiapterin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48183", "l": "H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203977", "l": "SAR1 Activation And Membrane Binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67573", "l": "3'-phosphoadenylyl sulfate + alpha-muricholate => adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24456", "l": "alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60917", "l": "a cytidine in mRNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678694", "l": "Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964842", "l": "Shikimate results from hydration of DHS (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49398", "l": "20S,23,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050098", "l": "methylguanidinase activity", "d": ["Catalysis of the reaction: H2O + methylguanidine = methylammonium + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16217", "l": "H2O + L-arabinono-1,4-lactone = H(+) + L-arabinonate", "d": [], "t": []}, {"i": "EC:3.1.1.15", "l": "\"L-arabinonolactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31373", "l": "(2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine => (2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050168", "l": "pentanamidase activity", "d": ["Catalysis of the reaction: H2O + pentanamide = NH4 + valerate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047520", "l": "11-cis-retinyl-palmitate hydrolase activity", "d": ["Catalysis of the reaction: 11-cis-retinyl palmitate + H2O = 11-cis-retinol + H+ + palmitate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37388", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56682", "l": "H2O + omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-dihydromenaquinone-9 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77707", "l": "GTP + UTP = 3',3'-cGMP-UMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34400", "l": "9-cis-beta-carotene + O2 => 9-cis-10'-apo-beta-carotenal + beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76612", "l": "H(+) + NADPH + vanillin => 4-hydroxy-3-methoxy-benzenemethanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626039", "l": "pGFAP binds GFAP in LAMP2a multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050137", "l": "NADPH peroxidase activity", "d": ["Catalysis of the reaction: H2O2 + H+ + NADPH = 2 H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0070492", "l": "oligosaccharide binding", "d": ["Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64720", "l": "H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43532", "l": "a ribonucleoside 3',5'-bisphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.97", "l": "\"3',5'-nucleoside bisphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68977", "l": "glycoursodeoxycholate + NADP(+) => 7-oxoglycolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58712", "l": "NADH + O2 + rifampicin = H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22878", "l": "(R)-mandelate + NH4(+) => (R)-mandelamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50033", "l": "H2O + hexadecanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696547", "l": "STAMBPL1 is a deubiquitinase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9842115", "l": "PSAP(195-273) dimer binds PE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187506", "l": "Translocation of p27 to the nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071967", "l": "lipopolysaccharide core heptosyltransferase activity", "d": ["Catalysis of the reaction: glucosyl-heptosyl2-KDO2-lipid A-phosphate + ADP-L-glycero-beta-D-manno-heptose = glucosyl-heptosyl3-KDO2-lipid A-phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52002", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O => a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28398", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate = L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "65.194086307115413", "identifiers": [{"i": "GO:0016755", "l": "aminoacyltransferase activity", "d": ["Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.3.2.-", "l": "\"Aminoacyltransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47358", "l": "an aliphatic alcohol + H(+) + octanoate => an octanoate ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35641", "l": "glyoxylate + pyruvate => (4S)-4-hydroxy-2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48448", "l": "a ganglioside GA2 + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734475", "l": "PPARA binds fibrates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77432", "l": "a ganglioside GT2 + UDP-alpha-D-galactose => a ganglioside GT1c + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080019", "l": "alcohol-forming very long-chain fatty acyl-CoA reductase activity", "d": ["Catalysis of the reaction: a very long-chain fatty acyl-CoA + NADPH + H+ = a very long-chain primary alcohol + NADP+ + CoA. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047633", "l": "agmatine kinase activity", "d": ["Catalysis of the reaction: agmatine + ATP = N(4)-phosphoagmatine + ADP + 3 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65950", "l": "A + a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + CoA + H(+) + 2 H2O => a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68311", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032428", "l": "beta-N-acetylgalactosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78730", "l": "(3S)-hydroxydocosanoyl-CoA + NAD(+) <=> 3-oxodocosanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.101", "l": "\"xanthomonalisin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450466", "l": "AUF1:mRNA complex is destroyed (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9825790", "l": "p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8950778", "l": "p-Y693-STAT4 dimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675198", "l": "Activated MAPKs phosphorylate BRAF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57673", "l": "(+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase] => 2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210805", "l": "Removal of miRNA passenger strand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11702", "l": "H2O + NADP(+) + testosterone acetate => H(+) + NADPH + O2 + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24267", "l": "D-xylulose 5-phosphate + formaldehyde <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78692", "l": "[(1->2)-beta-D-glucosyl](n) + a D-glucoside => [(1->2)-beta-D-glucosyl](n-1) + a beta-D-glucosyl-(1->2)-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358789", "l": "Self-ubiquitination of RNF41 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77469", "l": "2-hydroxy-2-methylbutanenitrile => butan-2-one + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61667", "l": "(2E,6E,10E)-geranylgeraniol + ATP <=> (2E,6E,10E)-geranylgeranyl phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106294", "l": "NADPH oxidase H202-forming activity", "d": ["Catalysis of the reaction: NADPH + H+ + O2 = NADP + hydrogen peroxide (H2O2)."], "t": []}, {"i": "RHEA:11260", "l": "H(+) + NADPH + O2 = H2O2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47304", "l": "(9Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681651", "l": "nsp8 generates RNA primers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210444", "l": "L-Glutamate loading of synaptic vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193700", "l": "p75NTR ICD signals to NF-kB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005056", "l": "tiggrin receptor activity", "d": ["Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11446", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352059", "l": "SLC6A15-mediated amino acid uptake (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867098", "l": "Glycophorins bind plasmodium falciparum Ags (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44844", "l": "(R)-carnitine + eicosanoyl-CoA = CoA + O-eicosanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19000", "l": "CTP + H(+) + phosphocholine <=> CDP-choline + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36530", "l": "(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA <=> (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22476", "l": "4-(hydroxyamino)quinoline N-oxide + H2O + 2 NADP(+) = 4-nitroquinoline N-oxide + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950322", "l": "Expression of ribosomal protein lateral stalk subunit P0 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24764", "l": "UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate", "d": [], "t": []}, {"i": "EC:5.1.3.23", "l": "\"UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22141", "l": "a nucleoside 5'-phosphate + H2O => a nucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62034", "l": "a 2-acyl-sn-glycero-3-phosphoglycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177934", "l": "EGFR autophosphorylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1980122", "l": "DTX binds NOTCH1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42647", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] <=> diphosphate + holo-[malonate decarboxylase ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30387", "l": "GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62983", "l": "(9Z)-hexadecenamide + H2O <=> (9Z)-hexadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.94", "l": "\"versiconal hemiacetal acetate esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9613497", "l": "Unwinding DNA for the nascent transcript (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210292", "l": "Interaction of DAP12 and TREM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37054", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218812", "l": "FYN phosphorylates PAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49003", "l": "aurachin C + H(+) + NADH + O2 <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60626", "l": "2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67738", "l": "aceneuramate => N-acetyl-alpha-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655849", "l": "Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12721", "l": "putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine", "d": [], "t": []}, {"i": "EC:2.5.1.16", "l": "\"spermidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59292", "l": "beta-D-galactosyl-(1<->1')-N-octadecanoylsphing-4-enine + H2O = D-galactose + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008930", "l": "methylthioadenosine nucleosidase activity", "d": ["Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030562", "l": "rRNA 2'-O-ribose methylation guide activity", "d": ["Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77380", "l": "H(+) + hnu + tetradecanoate => CO2 + tridecane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56756", "l": "5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin] = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17025", "l": "NADP(+) + xylitol = H(+) + L-xylulose + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.10", "l": "\"L-xylulose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9630923", "l": "NF-kappa-B inhibitor binds NF-kappa-B complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52626", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate => [amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68115", "l": "H2O + propanamide <=> NH4(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28378", "l": "ATP + N(6)-(D-fructosyl)-L-lysine = ADP + H(+) + N(6)-(6-phospho-D-fructosyl)-L-lysine", "d": [], "t": []}, {"i": "EC:2.7.1.218", "l": "\"fructoselysine 6-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065355", "l": "Secreted ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352893", "l": "glucose 6-phosphate <=> fructose 6-phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28404", "l": "ADP + H(+) + L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) => ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34255", "l": "sporulenol = (R)-tetraprenyl-beta-curcumene + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.137", "l": "\"sporulenol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9834807", "l": "ILF3 binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27580", "l": "(R)-piperazine-2-carboxylate + tert-butylamine => (R)-N-tert-butylpiperazine-2-carboxamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47538", "l": "isochenodeoxycholate + NADP(+) => 3-oxochenodeoxycholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837511", "l": "Abortive replication of hRSV A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050270", "l": "S-adenosylhomocysteine deaminase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O + H+ = S-inosyl-L-homocysteine + NH4."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22035", "l": "3-oxalomalate <=> glyoxylate + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140947", "l": "histone H3K9me2 methyltransferase activity", "d": ["Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13249", "l": "(R)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.268", "l": "\"2-(R)-hydroxypropyl-CoM dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44316", "l": "1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52617", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP => 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45985", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19174", "l": "H(+) + NADH + naphthalene + O2 => (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9620456", "l": "sGC stimulators bind sGC:NO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55396", "l": "(R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247837", "l": "WNT ligands traffic to the Golgi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951490", "l": "CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70645", "l": "D-proline(in) + H(+)(in) => D-proline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67083", "l": "a very long-chain fatty acid(in) + ATP + H2O <=> a very long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65423", "l": "GMP(in) + NAD(+)(out) <=> GMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31104", "l": "7,8-dihydrofolate + NADP(+) => folate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41705", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O => 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64940", "l": "dGDP + H2O = dGMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047498", "l": "calcium-dependent phospholipase A2 activity", "d": ["Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+."], "t": []}, {"i": "REACT:R-HSA-111883", "l": "Hydrolysis of phosphatidylcholine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990528", "l": "Interaction of PCBP2 with MAVS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69365", "l": "6-diazo-5-oxo-L-norleucine + acetyl-CoA => CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37173", "l": "1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2032775", "l": "YAP1 binds TEAD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48544", "l": "[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.233", "l": "\"[phosphatase 2A protein]-leucine-carboxy methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38673", "l": "sphinganine 1-phosphate(out) => sphinganine 1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372564", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948582", "l": "miR-17 microRNA binds VAPA mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004635", "l": "phosphoribosyl-AMP cyclohydrolase activity", "d": ["Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H2O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653514", "l": "USP17L2 deubiquitinates RCE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71280", "l": "chloride(out) + L-leucine(out) + 2 Na(+)(out) => chloride(in) + L-leucine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42798", "l": "cholesteryl (9Z,12Z)-octadecadienoate + CoA => (9Z,12Z)-octadecadienoyl-CoA + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084999", "l": "NEU1 hydrolyses Neu5Ac from glycoconjugates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20991", "l": "ATP + 2 H2O <=> AMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22014", "l": "precorrin-5 + S-adenosyl-L-homocysteine => precorrin-4 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005133", "l": "type II interferon receptor binding", "d": ["Binding to a type II interferon receptor. Type II interferon is also known as interferon-gamma."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694527", "l": "Loss of SAR1B GTPase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20282", "l": "(Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate => (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54741", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73920", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+) => H2O + norlichexanthone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52051", "l": "9-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20515", "l": "2-arylpropionate + CO2 => 2-aryl-2-methylmalonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52237", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + Fe(2+) + 3 H2O + mycobilin b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805103", "l": "AURKA phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15099", "l": "(6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate => 5-formimidoyltetrahydrofolate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112435", "l": "Formation of Elongin BC complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18390", "l": "alpha-D-xylose 1-phosphate + H(+) + UTP => diphosphate + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209566", "l": "TRAF6 is auto-ubiquitinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086216", "l": "Collagen type VII binds integrin alpha2beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.1.15", "l": "\"nitrite reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050117", "l": "N-acetyl-beta-alanine deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-beta-alanine + H2O = beta-alanine + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707516", "l": "FeHM dissociates from MetHb (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22562", "l": "2'-hydroxyformononetin + 2 H(+) + NADPH => (3R)-vestitone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949580", "l": "F1Fo ATP synthase dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62086", "l": "AMP + D-glucosamine 6-phosphate + H(+) => ADP + D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16162", "l": "2 Fe(III)-[leghemoglobin] + NADH => 2 Fe(II)-[leghemoglobin] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35941", "l": "diphosphate + tryprostatin B => brevianamide F + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158399", "l": "kallikrein binds SERPING1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70287", "l": "1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41945", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189381", "l": "BIL translocates from the cytosol to the ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76877", "l": "H(+) + hexan-2-one + NADH + NH4(+) => H2O + hexan-2-amine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9608039", "l": "NR1H2,3 binds the PLIN1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25350", "l": "D-tyrosyl-tRNA(Tyr) + H2O <=> D-tyrosine + tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78482", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53366", "l": "H(+) + NADH + uridine(47) in tRNA => 5,6-dihydrouridine(47) in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5607734", "l": "PKC-delta translocates to plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58857", "l": "(6E)-8-hydroxygeraniol + NAD(+) => (6E)-8-oxogeraniol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28743", "l": "nitrate(in) + nitrite(out) = nitrate(out) + nitrite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45902", "l": "a 4-saturated (2E)-enoyl-CoA => a (3Z)-enoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34608", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine => a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0052619", "l": "coenzyme F420-1:gamma-L-glutamate ligase activity", "d": ["Catalysis of the reaction: GTP + L-glutamate + factor gamma-F420-1 = GDP + H+ + factor gamma-F420-2 + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58862", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983152", "l": "Transfer of ubiquitin from E1 to E2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69105", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine => H2O + kynurenate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77599", "l": "2 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67167", "l": "bromide + FADH2 + melleolide F + O2 <=> 6'-bromomelleolide F + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27737", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O <=> 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72781", "l": "FAD + 2 H2O + ochratoxin A => chloride + FADH2 + O2 + ochratoxin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11929", "l": "hydroxylamine + NH4(+) => H(+) + H2O + hydrazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74673", "l": "UDP-beta-L-arabinopyranose(out) + UMP(in) => UDP-beta-L-arabinopyranose(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73683", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphing-4-enine = a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46254", "l": "a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0070704", "l": "sterol desaturase activity", "d": ["Catalysis of the introduction of a double bond into a sterol molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78085", "l": "1-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+) => 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031014", "l": "troponin T binding", "d": ["Binding to troponin T, the tropomyosin-binding subunit of the troponin complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55719", "l": "(S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009541", "l": "ESR1 binds to TFF1 gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933539", "l": "Recruitment of IKK complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49310", "l": "a neolactoside nLc4Cer(d18:0) + L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30261", "l": "2 a menaquinone + n H(+)(out) + 2 H2O(in) => 2 a menaquinol + n H(+)(in) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418082", "l": "Dissociation of telomerase RNP from the extended chromosomal end (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761830", "l": "NFE2L2 binds the TALDO1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76425", "l": "(8S)-annullatin J + diphosphate => (8S)-annullatin E + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9842649", "l": "Active LTK receptor binds PI3K (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015254", "l": "glycerol channel activity", "d": ["Enables the energy-independent facilitated diffusion of glycerol through a transmembrane aqueous pore or channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031867", "l": "EP4 subtype prostaglandin E2 receptor binding", "d": ["Binding to an EP4 subtype prostaglandin E2 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23829", "l": "2-dehydro-D-gluconate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809663", "l": "Formation of hair keratin fibres (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28606", "l": "L-valine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-2-methylpropanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.38", "l": "\"valine N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24470", "l": "H2O + N,N-dimethylaniline N-oxide + NADP(+) => H(+) + N,N-dimethylaniline + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12252", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + H2O = (E)-coniferol + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.126", "l": "\"coniferin beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9007901", "l": "IL1F10 binds IL1RL2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73212", "l": "H(+)(in) + sucrose(out) => H(+)(out) + sucrose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38611", "l": "NAD(+) = cyclic ADP-beta-D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73685", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42761", "l": "D-glyceraldehyde 3-phosphate + H2O + NAD(+) => (2R)-3-phosphoglycerate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033732", "l": "pyrroloquinoline-quinone synthase activity", "d": ["Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 2 H2O + 2 H2O2 + H+ + pyrroloquinoline quinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004699", "l": "diacylglycerol-dependent, calcium-independent serine/threonine kinase activity", "d": ["Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium."], "t": []}, {"i": "REACT:R-HSA-5607740", "l": "PKC-delta phosphorylates CARD9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72473", "l": "citrate(in) + D-threo-isocitrate(out) => citrate(out) + D-threo-isocitrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49538", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O => 2-amino-2-deoxy-D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20712", "l": "6-carboxyhexanoyl-CoA + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004867", "l": "serine-type endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78204", "l": "D-valine + H2O + O2 => 3-methyl-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102760", "l": "6-deoxocathasterone hydroxylase activity", "d": ["Catalysis of the reaction: 6-deoxycathasterone + O2 + a reduced electron acceptor = 6-deoxoteasterone + H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61237", "l": "H2O + L-methionine + O2 => 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0004112", "l": "cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17581", "l": "an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O = an L-alpha-amino acid + CO2 + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.87", "l": "\"N-carbamoyl-L-amino-acid hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71264", "l": "chloride(out) + L-proline(out) + 2 Na(+)(out) => chloride(in) + L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170986", "l": "Ral-GDS binds to Ras-GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169192", "l": "PTP1B dephosphorylates GHR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50800", "l": "glutathione + prostaglandin A2 = prostaglandin A2-S-(S)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187506", "l": "Translocation of p27 to the nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382057", "l": "Release of novel PDGFs as latent factors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47808", "l": "epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71317", "l": "chloride(in) + L-serine(in) + 2 Na(+)(in) => chloride(out) + L-serine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38178", "l": "all-trans-retinol + hexadecanoyl-CoA <=> all-trans-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173723", "l": "C8 binds C5b:C6:C7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018561", "l": "2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16166", "l": "L-tryptophan + O2 => CO2 + H2O + indole-3-acetamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564169", "l": "Collagen type VIII degradation by MMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683746", "l": "Protein 3a forms a homotetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33715", "l": "4-hydroxyeicosasphinganine 1-phosphate = 2-hydroxyoctadecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357479", "l": "p-AXL binds PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795134", "l": "Cipro is sulfonated to sulfo-Cipro (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2317332", "l": "PIP3 recruits AKT to the membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14993", "l": "acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.85", "l": "\"fatty-acid synthase system\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728664", "l": "GLP1R binds GLP1R agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28962", "l": "D-xylose(in) + H(+)(in) <=> D-xylose(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901039", "l": "MAN1B1 hydrolyses 1,2-linked mannose (c branch) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30141", "l": "CoA + H(+) + octadecanoate => H2O + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35511", "l": "glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] = glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21019", "l": "H2O + L-asparagine <=> L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21547", "l": "(2E,6E)-farnesyl diphosphate + ATP <=> (2E,6E)-farnesyl triphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30944", "l": "FAD + H(+) + octanoyl-CoA => (2E)-octenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34635", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 = H2O + NADP(+) + pentalenolactone D", "d": [], "t": []}, {"i": "EC:1.14.13.170", "l": "\"pentalenolactone D synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018602", "l": "2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity", "d": ["Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44879", "l": "a 1,3-diacylglycerol + H2O <=> a 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19508", "l": "indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose <=> (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77435", "l": "a ganglioside GT1c + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1c + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32671", "l": "ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.176", "l": "\"UDP-N-acetylglucosamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78883", "l": "6-O-methyl-N-deacetylipecoside + H2O = 6-O-methyl-N-deacetylipecoside aglycone + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74349", "l": "O-acyl-(R)-carnitine(out) => O-acyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29688", "l": "alpha-maltoheptaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltohexaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55088", "l": "eburicol + S-adenosyl-L-methionine = (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42829", "l": "2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051065", "l": "CTP reductase activity", "d": ["Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089715", "l": "tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine at position 37 = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine at position 37."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18653", "l": "barbiturate + H2O = 3-oxo-3-ureidopropanoate", "d": [], "t": []}, {"i": "EC:3.5.2.1", "l": "\"barbiturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64511", "l": "acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine <=> 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36620", "l": "2-hydroxydocosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxydocosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29670", "l": "H2O(in) <=> H2O(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48777", "l": "O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809680", "l": "MTMR12 binds MTM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53401", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66360", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O = (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34791", "l": "2-hydroxyethylphosphonate + O2 = formate + H(+) + hydroxymethylphosphonate", "d": [], "t": []}, {"i": "EC:1.13.11.72", "l": "\"2-hydroxyethylphosphonate dioxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57309", "l": "CTP + H(+) + N(5)-phospho-L-glutamine => diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047447", "l": "erythro-3-hydroxyaspartate ammonia-lyase activity", "d": ["Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60702", "l": "a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline => a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44897", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose => H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17303", "l": "ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] => ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451900", "l": "IL2RB binds JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62554", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP => beta-D-glucosylceramide + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102956", "l": "UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + sinapoyl aldehyde = H+ + sinapaldehyde glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9861563", "l": "CTLH E3 ligase ubiquitinates LDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68715", "l": "(2E,6E)-farnesyl diphosphate <=> (1S,2S,4R)-beta-elemene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062066", "l": "PSII associated light-harvesting complex II binding", "d": ["Binding to a PSII associated light-harvesting complex II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54502", "l": "beta-geranylfarnesene + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013158", "l": "CDC42 GDIs block activation of CDC42 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72068", "l": "(2S)-2-aminobutanoate + ATP + L-glutamate => ADP + gamma-L-glutamyl-(2S)-2-aminobutanoate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43752", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]", "d": [], "t": []}, {"i": "EC:2.3.1.267", "l": "\"[ribosomal protein uS5]-alanine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64338", "l": "4-hydroxy-6-(pyridin-3-yl)-2H-pyran-2-one + 2 CO2 + 3 CoA => H(+) + 2 malonyl-CoA + nicotinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67089", "l": "ATP + H2O + tetracosanoate(in) => ADP + H(+) + phosphate + tetracosanoate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71943", "l": "(S)-malate(out) + 3 Na(+)(out) = (S)-malate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51237", "l": "GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n) => GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990965", "l": "cytosylglucuronate decarboxylase activity", "d": ["Catalysis of the reaction: cytosylglucuronic acid + H+ = cytosylarabinopyranose + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706336", "l": "Active FLT3 binds to SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15307", "l": "glycine betaine + 2 H(+) + NADH => betaine aldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67360", "l": "H2O + L-threonyl-L-threonine = 2 L-threonine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130504", "l": "Cleavage of lip22 to lip10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24066", "l": "H(+) + 2 H2O + porphobilinogen => 2 5-aminolevulinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424484", "l": "Phosphorylation of BTK by p-SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15424", "l": "a long-chain fatty acid + ATP + CoA <=> a long-chain fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15219", "l": "CoA + ecdysone hexadecanoate => ecdysone + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029551", "l": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944266", "l": "Association of procollagen type XI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30133", "l": "H(+) + holo-[ACP] + octanoate => H2O + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214418", "l": "REL binds to monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15469", "l": "1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}, {"i": "EC:5.3.1.16", "l": "\"1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111879", "l": "PIP2 hydrolysis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62024", "l": "campesteryl 3-beta-D-glucoside + H2O = campesterol + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51853", "l": "(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) => (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37924", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26187", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O <=> 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113429", "l": "Elongating transcript encounters a lesion in the template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59055", "l": "D-lysine + H(+) <=> cadaverine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15753", "l": "GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.4", "l": "\"adenylosuccinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20873", "l": "(20S)-ginsenoside Rd + UDP-alpha-D-glucose => (20S)-ginsenoside Rb1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662986", "l": "MT2A binds copper (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70638", "l": "H2O + N(6)-octanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-octanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446221", "l": "GMPPB converts Mannose-1-phosphate to GDP-Mannose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15107", "l": "H(+) + kaempferide + S-adenosyl-L-homocysteine => kaempferol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43574", "l": "5-guanidino-2-oxopentanoate + AH2 + NH4(+) => A + D-arginine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705726", "l": "SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090562", "l": "protein-N(PI)-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N,N'-diacetylchitobiose(out) = protein histidine + N,N'-diacetylchitobiose phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74502", "l": "H(+) + NADPH + yaequinolone D <=> H2O + NADP(+) + penigequinolone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814409", "l": "CK2 phosphorylates PDCL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12456", "l": "CTP + D-ribitol 5-phosphate + H(+) = CDP-L-ribitol + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.40", "l": "\"D-ribitol-5-phosphate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13282", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) => 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12806", "l": "(S)-canadine + S-adenosyl-L-methionine => (S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60284", "l": "N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654603", "l": "Activated FGFR2 binds FRS3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0004084", "l": "branched-chain-amino-acid transaminase activity", "d": ["Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73929", "l": "griseophenone C + S-adenosyl-L-homocysteine => griseophenone D + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034597", "l": "phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65932", "l": "3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine = 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36904", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804100", "l": "HMGB1 binds LPS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40356", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020504", "l": "MECP2 binds GRIN2B gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419440", "l": "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63669", "l": "CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+) => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869580", "l": "DEK binds TFAP2A homodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684030", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9842660", "l": "LTK binds ALKAL ligand (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679029", "l": "C-ter TLR7 dimer binds HCQ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21447", "l": "3-(2-hydroxyphenyl)propanoate + NAD(+) <=> H(+) + NADH + trans-2-coumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27682", "l": "ATP + dTDP = ADP + dTTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29571", "l": "H(+)(in) + L-idonate(in) = H(+)(out) + L-idonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-417820", "l": "P2Y9 receptor can bind to LPA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15393", "l": "(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate", "d": [], "t": []}, {"i": "EC:5.1.1.7", "l": "\"diaminopimelate epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32268", "l": "4-aminobutanoate + glyoxylate => glycine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878117", "l": "RUNX3 binds ZFHX3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18695", "l": "6-aminopenicillanate + a carboxylate => a penicillin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31502", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49013", "l": "aurachin C + H(+) + NADH + O2 => aurachin C epoxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34156", "l": "acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine => CoA + H(+) + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9698844", "l": "MLKL binds HSP90:CDC37 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71698", "l": "2 H(+)(out) + L-alanyl-L-aspartate(out) <=> 2 H(+)(in) + L-alanyl-L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796068", "l": "AcK-NFE2L2 binds the ATF4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-593685", "l": "Netrin-4 binds DCC/UNC5A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23612", "l": "1,2-dihydro-alpha-santonin + NAD(+) = alpha-santonin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200555", "l": "Formation of Malonyl-CoA from Acetyl-CoA (liver) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77989", "l": "9-(acyloxy)-octadecanoate + a 1,3-diacylglycerol => 9-hydroxy-octadecanoate + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33389", "l": "aminopropylcadaverine + H(+) + S-methyl-5'-thioadenosine => cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380294", "l": "Loss of C-Nap-1 from centrosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4167511", "l": "HLCS biotinylates ACACB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21097", "l": "3-dehydroquinate => 3-dehydroshikimate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2106614", "l": "Duplex miRNA is loaded into Argonaute (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15404", "l": "a dolichyl phosphate + UDP-alpha-D-glucose <=> a dolichyl beta-D-glucosyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45135", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944219", "l": "Association of procollagen type XVI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48911", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61175", "l": "myricetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29856", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine => D-alanine + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74251", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78376", "l": "H(+) + NADPH + S-nitroso-CoA => NADP(+) + sulfinamide-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43051", "l": "keto-D-tagatose <=> keto-D-sorbose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30075", "l": "CMP + H2O = cytosine + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22551", "l": "H2O + L-lysine + O2 <=> (S)-2-amino-6-oxohexanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77769", "l": "11-cis-retinyl ester + CoA => 11-cis-retinol + a fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11739", "l": "2-exo-hydroxy-1,8-cineole + NAD(+) <=> 6-oxocineole + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797627", "l": "ASPG hydrolyses L-Asn to L-Asp (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33808", "l": "(E)-ferulate + H(+) => 2-methoxy-4-vinylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362386", "l": "Glycosylation of Hh (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592398", "l": "Activation of proMMP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.73", "l": "\"feruloyl esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70000", "l": "L-threonine(in) + Na(+)(in) => L-threonine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10576", "l": "CTP + H(+) + N-methylethanolamine phosphate = CDP-N-methylethanolamine + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.57", "l": "\"N-methylphosphoethanolamine cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57587", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-171087", "l": "LDLR [endosome membrane] => LDLR [plasma membrane] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60096", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 3-dehydro-4alpha-methylzymosterol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2172678", "l": "PHF8 demethylates histone H4K20me1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212222", "l": "PRC2 recruits DNA methyltransferases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40697", "l": "1-O-heptadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + heptadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37705", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10059", "l": "(3S)-3-aminobutanoyl-CoA <=> (2E)-butenoyl-CoA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449976", "l": "IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73203", "l": "D-glucose(out) + H(+)(in) = D-glucose(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24705", "l": "NAD(+) + UDP-alpha-D-glucuronate <=> CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9639286", "l": "RRAGC,D exchanges GTP for GDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448678", "l": "CTSG cleaves CASP1(1-404) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10078", "l": "beta-D-galactose + D-glucose => H2O + lactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35546", "l": "3-phosphooxypyruvate + H2O <=> 3-hydroxypyruvate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29102", "l": "a menaquinone + 5 H(+)(in) + NADH <=> a menaquinol + 4 H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22866", "l": "D-lysine => L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418925", "l": "ADORA2A,B bind Ade-Rib (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11685", "l": "methylarsonous acid + S-adenosyl-L-methionine => dimethylarsinate + 2 H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679205", "l": "ULK1 phosphorylates Beclin-1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39999", "l": "a sphingoid 1-phosphate = a fatty aldehyde + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42511", "l": "6-acetamido-2-oxohexanoate + H2O + NAD(+) <=> 5-acetamidopentanoate + CO2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102828", "l": "stachyose galactinol:verbascose galactosyltransferase activity", "d": ["Catalysis of the reaction: stachyose + alpha-D-galactosyl-(1->3)-1D-myo-inositol = verbascose + myo-inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52695", "l": "3-phenyllactate + NADP(+) <=> 3-phenylpyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66335", "l": "L-aspartate(out) <=> L-aspartate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756603", "l": "SARS-CoV-1 S binds SFTPD 12mer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43908", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H2O = D-galactose + sphing-4-enine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17369", "l": "glycyrrhizin + H2O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate", "d": [], "t": []}, {"i": "EC:3.2.1.128", "l": "\"glycyrrhizinate beta-glucuronidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002460", "l": "P4HB binds Collagen chains (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18450", "l": "A + arsenite + H2O => AH2 + arsenate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55793", "l": "butan-2-one + H(+) + NADH + O2 => 1-hydroxy-2-butanone + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863463", "l": "STON2 binds SYT proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73045", "l": "creatine(out) => creatine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181152", "l": "Cleavage of NODAL proprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52236", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 = 3 A + Fe(2+) + 3 H2O + mycobilin b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66525", "l": "L-ascorbate(in) + monodehydro-L-ascorbate radical(out) => L-ascorbate(out) + monodehydro-L-ascorbate radical(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9669854", "l": "KIT binds type II TKIs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12741", "l": "ADP + H(+) + H2O = IDP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018729", "l": "propionate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15039", "l": "H(+) + N-methylputrescine + S-adenosyl-L-homocysteine => putrescine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199154", "l": "CD200 binds to CD200R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52625", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-glutamate => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917696", "l": "Cargo Sequestration (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2984220", "l": "CDK1:CCNB phosphorylates NEK9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10524", "l": "2-oxoglutarate + H(+) = CO2 + succinate semialdehyde", "d": [], "t": []}, {"i": "EC:4.1.1.71", "l": "\"2-oxoglutarate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66857", "l": "(2E)-geranyl diphosphate + 3 isopentenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449978", "l": "IL7 binds IL7R:JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13267", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine => 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372903", "l": "lactate + NAD+ <=> pyruvate + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473594", "l": "Collagen type II degradation by MMP15 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420121", "l": "SFKs phosphorylate PLCG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954117", "l": "E2F6:TFDP1 binds EPC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41173", "l": "2-hexadecenoyl-sn-glycero-3-phosphate + a fatty acid + H(+) => 1-acyl-2-hexadecenoyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664892", "l": "SQSTM1 binds ATM dimer:Ub-p-PEX5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60104", "l": "H(+) + indole-3-propanoate + oxidized [electron-transfer flavoprotein] = (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47075", "l": "1-eicosanoylglycerol + H2O <=> eicosanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12832", "l": "(2S,3S)-3-methyl-L-aspartate <=> mesaconate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696266", "l": "RND2 binds effectors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28198", "l": "(S)-1-phenylethanol + NAD(+) = acetophenone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.311", "l": "\"(S)-1-phenylethanol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77474", "l": "hydrogen cyanide + pentan-2-one <=> (2S)-2-hydroxy-2-methylpentanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68532", "l": "(2E,6E)-farnesyl diphosphate = (Z)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483186", "l": "PC is converted to PS by PTDSS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36366", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH <=> (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299318", "l": "Activation of TASK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047326", "l": "inositol tetrakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34941", "l": "menaquinol-8 + selenate => H2O + menaquinone-8 + selenite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030215", "l": "semaphorin receptor binding", "d": ["Binding to a semaphorin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693593", "l": "D-loop extension by DNA polymerases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73548", "l": "GTP(out) + UTP(in) => GTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38192", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone => 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48026", "l": "dipropanoylglycerol + H(+) + propanoate => 1,2,3-tripropanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63304", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1964496", "l": "STING binds TRIM32 or TRIM56  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76081", "l": "a dicarboxylate(out) + L-sepiapterin(in) => a dicarboxylate(in) + L-sepiapterin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20295", "l": "3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH => 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156699", "l": "Inactivation of Wee1 kinase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0071917", "l": "triose-phosphate transmembrane transporter activity", "d": ["Enables the transfer of a triose phosphate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205319", "l": "Interaction of APS and p-KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1297444", "l": "Binding of cAMP to HCN channels (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45769", "l": "gamma-L-glutamyl-L-alaninol + H2O => L-alaninol + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435244", "l": "PECAM1 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39101", "l": "acetyl-CoA + octanedioyl-CoA => 3-oxodecanedioyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611839", "l": "β3-agonists bind ADRB3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687455", "l": "HSV1 RIR1 binds RIPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033734", "l": "(R)-benzylsuccinyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130349", "l": "Generation of CLIP from lip10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48853", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 => 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592297", "l": "Full activation of MMP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20600", "l": "2 L-cysteine + NAD(+) <=> H(+) + L-cystine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68664", "l": "17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate = 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045522", "l": "interleukin-26 receptor binding", "d": ["Binding to an interleukin-26 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194678", "l": "CYP51A1 demethylates LNSOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66155", "l": "acetyl-CoA + noradrenaline <=> CoA + H(+) + N-acetylnoradrenaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71811", "l": "3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L-thyronine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74287", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69552", "l": "dihydroxyacetone phosphate + L-glutamate = (S)-serinol phosphate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975594", "l": "PLB1 hydrolyses RPALM to atROL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16479", "l": "15-oxoprostaglandin E1 + H(+) + NADH => NAD(+) + prostaglandin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162193", "l": "COQ3 methylates DHDB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202731", "l": "JAM3 dimerises (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67026", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209536", "l": "IkB is ubiquitinated and degraded (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9840488", "l": "PSAP(195-273) forms a dimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29615", "l": "alpha-maltotriose + beta-maltose = alpha-maltotetraose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68101", "l": "NAD(+) + xylitol => H(+) + L-xylulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62642", "l": "[mycoredoxin]-L-disulfide + an alcohol + H2O => [mycoredoxin]-L-dithiol + a hydroperoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55600", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phosphoceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27464", "l": "D-glycero-alpha-D-manno-heptose 1-phosphate + GTP + H(+) <=> diphosphate + GDP-D-glycero-alpha-D-manno-heptose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75551", "l": "2 a (3R)-3-isocyanyl-fatty acyl-[ACP] + ATP + L-lysine + 2 NADPH = AMP + an isonitrile lipopeptide + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51171", "l": "(R)-adrenaline + H2O + O2 <=> (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78102", "l": "a 1-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015381", "l": "high-affinity sulfate transmembrane transporter activity", "d": ["Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64248", "l": "decanoyl-CoA + glycine = CoA + H(+) + N-decanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11056", "l": "4-aminobenzoate + 2 H(+) + NADPH + O2 = 4-aminophenol + CO2 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58546", "l": "H2O + 2 monodehydro-L-ascorbate radical + N-tetradecanoyl-(2S)-hydroxyglycine => 2 L-ascorbate + N-tetradecanoylglycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873927", "l": "Release of STAT1 dimer from active receptor unit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5227009", "l": "ABCF1 binds EIF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35741", "l": "4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone => cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50944", "l": "3-phenylpropanoate + NAD(+) = (E)-cinnamate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419843", "l": "CALCA(83-119) binds CALCR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26065", "l": "ATP + hygromycin B => 4-O-phosphohygromycin B + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66138", "l": "CoA + H(+) + N-acetyltyramine => acetyl-CoA + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68449", "l": "13-cis-lycopene + O2 => (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023549", "l": "PTPN1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17968", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) <=> (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48078", "l": "4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde => a primary alcohol + N,N-dimethyl-4-nitrosoaniline", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10661", "l": "L-seryl-[protein] => D-seryl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43084", "l": "cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18648", "l": "2 putrescine <=> NH4(+) + sym-homospermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22066", "l": "ergosterol + H2O => 5alpha-ergosta-7,22-diene-3beta,5-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803989", "l": "Nitric oxide and O2 react to NO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16839", "l": "a carboxylate + AMP + 2 H(+) => 5'-acylphosphoadenosine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43846", "l": "(3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+) => (3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15874", "l": "[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose => [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.97", "l": "\"3-sulfolactaldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32937", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a fatty acid + H(+) => a cardiolipin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49370", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + diphosphate => 19-(4-hydroxyphenyl)nonadecanoate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18692", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654397", "l": "Activated FGFR2 phosphorylates FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76528", "l": "2'-deoxyguanosine + H(+) + H2O => 2'-deoxyxanthosine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035614", "l": "snRNA stem-loop binding", "d": ["Binding to a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74053", "l": "D-threonine(in) + L-alanine(out) => D-threonine(out) + L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032140", "l": "single adenine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single adenine insertion or a deletion that results in an unpaired adenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709098", "l": "DHFR dimer reduces FOLA to DHF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2328037", "l": "Fibrillin-1 binds integrins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0010178", "l": "IAA-amino acid conjugate hydrolase activity", "d": ["Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.69", "l": "\"type 1 galactoside alpha-(1,2)-fucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57848", "l": "2-oxoglutarate + O2 + scopoletin = CO2 + fraxetin + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.60", "l": "\"scopoletin 8-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380316", "l": "Association of NuMA with microtubules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70319", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32097", "l": "CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose + H(+) => acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:1901702", "l": "salt transmembrane transporter activity", "d": ["Enables the transfer of salt from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382058", "l": "Nck binds to the active PDGF receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46928", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}, {"i": "EC:5.1.3.34", "l": "\"monoglucosyldiacylglycerol epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951500", "l": "Dissociation of CANX from nonameric complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839072", "l": "HTRA2 degrades APP (Amyloid-beta precursor protein) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59720", "l": "D-maltohexaono-1,5-lactone + H2O = D-maltohexaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863463", "l": "STON2 binds SYT proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166387", "l": "The FA anion diffuses away laterally from UCP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74977", "l": "a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+) => a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070996", "l": "type 1 melanocortin receptor binding", "d": ["Binding to a type 1 melanocortin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446634", "l": "IRAK4 is activated by autophosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33043", "l": "(1R,4R)-camphor + H(+) + NADPH + O2 = (+)-6-exo-hydroxycamphor + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.161", "l": "\"(+)-camphor 6-exo-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64098", "l": "2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP] => 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78460", "l": "a [peptide](out) + ATP + H2O => a [peptide](in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684032", "l": "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982807", "l": "JAK2 phosphorylation of GHR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097008", "l": "(3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity", "d": ["Catalysis of the reaction: (E)-nerolidol + NADPH + O2 = (3E)-4,8-dimethylnona-1,3,7-triene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C11-geranylacetone and then cleaved to produce (3E)-4,8-dimethylnona-1,3,7-triene (DMNT) and acetone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48413", "l": "a globoside IV3GalNAc-Gb4Cer + H2O => a globoside Gb4Cer + N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019174", "l": "tetrahydrothiophene 1-oxide reductase activity", "d": ["Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68231", "l": "glycine(in) + Na(+)(in) <=> glycine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70384", "l": "3-oxosphinganine + hexadecanoyl-CoA => CoA + H(+) + N-hexadecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43362", "l": "an N-acyl-beta-D-glucosyl-(1<->1')-sphinganine + H(+) + UDP => an N-acylsphinganine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71022", "l": "L-phenylalanine(out) + L-valine(in) <=> L-phenylalanine(in) + L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507868", "l": "Aquaporins passively transport water into cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043884", "l": "CO-methylating acetyl-CoA synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29336", "l": "H2O + L-alanyl-L-glutamate => L-alanine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61981", "l": "H(+) + NADPH + ubiquinone-10 => NADP(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209815", "l": "Tyrosine is monoiodinated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211960", "l": "CYP2U1 19-hydroxylates ARA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55451", "l": "a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213207", "l": "Formation of collagen networks (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66483", "l": "gypsogenin + UDP-alpha-D-glucose <=> gypsogenin 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047526", "l": "2'-hydroxyisoflavone reductase activity", "d": ["Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0031626", "l": "beta-endorphin binding", "d": ["Binding to beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621289", "l": "PINK1 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12930", "l": "2-oxoglutarate + acetyl-CoA + H2O => (2R)-homocitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021306", "l": "C1-Inh binds and inactivates C1r, C1s (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32597", "l": "6-hydroxy-3,7-dimethyloctanoate + H(+) => 7-isopropyl-4-methyloxepan-2-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388605", "l": "POMC(138-176) binds MC2R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.194", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051060", "l": "pullulanase activity", "d": ["Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in pullulan (a linear polymer of alpha-(1,6)-linked maltotriose units) and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46150", "l": "a 2'-deoxyribonucleoside + H(+) + triphosphate => a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9728150", "l": "SLC5A2 binds gliflozins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.17", "l": "\"calcium/calmodulin-dependent protein kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68973", "l": "A + sn-glycerol 3-phosphate => AH2 + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004902", "l": "granulocyte colony-stimulating factor receptor activity", "d": ["Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004118", "l": "cGMP-stimulated cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74723", "l": "Endosome acidification (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9824994", "l": "RPS6KA1-dependent phosphorylation of MITF-M (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944261", "l": "Association of procollagen type XIII (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209924", "l": "Dopa is decarboxylated to dopamine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3785684", "l": "Fibronectin degradation by CTSG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23068", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA = 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.94", "l": "\"6-deoxyerythronolide-B synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60926", "l": "CO2 + formaldehyde + L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852019", "l": "MET bound PI3K generates PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705323", "l": "Phosphorylation of TBK1/IKBKE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0090434", "l": "oleoyl-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + oleic acid + CoA = AMP + diphosphate + oleoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6790454", "l": "SUMOylation of XPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53938", "l": "19-hydroxy-thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + thromboxane A2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20390", "l": "(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 => (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2464822", "l": "RDH12 reduces atRAL to atROL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141409", "l": "Mad1 binds kinetochore (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10411", "l": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA <=> 3-oxopristanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0003988", "l": "acetyl-CoA C-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72379", "l": "chloride(out) + iodide(in) = chloride(in) + iodide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71789", "l": "(R)-2-hydroxyglutarate + CO2 => 2-oxoadipate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44549", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66094", "l": "H2O + kynurenate + L-phenylalanine => 3-phenylpyruvate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11642", "l": "an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH => a (2R,3R)-flavan-3-ol + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68184", "l": "a medium-chain fatty acyl-CoA + H2O = a medium chain fatty acid + CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.19", "l": "\"ADP-dependent medium-chain-acyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40416", "l": "H2O + pristanoyl-CoA => 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27552", "l": "(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate => di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617832", "l": "FOXO4:ATXN3 binds SOD2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56944", "l": "AH2 + D-ribulose 5-phosphate = 1-deoxy-D-xylulose 5-phosphate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52818", "l": "an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750666", "l": "ALB binds ST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17232", "l": "acetyl-CoA + an aliphatic alcohol <=> an acetyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53736", "l": "a 2-halobenzoate + H(+) + NADH + O2 = a halide anion + catechol + CO2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340214", "l": "CYGB binds O2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40215", "l": "FADH2 + O2 = FAD + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352981", "l": "phosphoenolpyruvate + H2O <=> 2-phosphoglycerate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35433", "l": "cyanidin 3,7-di-O-beta-D-glucoside + vanillate => 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028263", "l": "PGJ3 isomerises to δ12-PGJ3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67424", "l": "a glycerophospholipid + H2O = a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17878", "l": "a catechol + S-adenosyl-L-methionine => a guaiacol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654511", "l": "FGFRL1 dimer binds FGFs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32749", "l": "ethanolamine(out) => ethanolamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14336", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69389", "l": "(S)-2-ureidoglycine + carbamoyl phosphate => allantoate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20621", "l": "ATP + H2O + Zn(2+)(in) = ADP + H(+) + phosphate + Zn(2+)(out)", "d": [], "t": []}, {"i": "EC:7.2.2.12", "l": "\"P-type Zn(2+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12702", "l": "[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O => [thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018725", "l": "trans-3,4-dihydrodiolphenanthrene sulfotransferase activity", "d": ["Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78788", "l": "apigenin + UDP-alpha-D-glucose => H(+) + isovitexin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.5.3", "l": "\"glycerol-3-phosphate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38376", "l": "bacterioruberin => bisanhydrobacterioruberin + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66737", "l": "ATP + beta-citrylglutamate(in) + H2O => ADP + beta-citrylglutamate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35128", "l": "L-alanyl-D-glutamate(out) => L-alanyl-D-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205262", "l": "Direct recruitment of PI3K to p-KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47588", "l": "a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1c (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306876", "l": "NLRP3 activation by small molecules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31025", "l": "dammara-20,24-diene => squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018463", "l": "6-hydroxyhexanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10414", "l": "AMP + D-ribose 5-phosphate + 2 H(+) => ADP-D-ribose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61456", "l": "7-chlorotetracycline + H(+) + NADPH + O2 = (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044688", "l": "7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity", "d": ["Catalysis of the reaction: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65859", "l": "A + a 1-hydroxy-3-oxo steroid <=> a steroid 1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9702818", "l": "CALCR binds erenumab (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798081", "l": "TP53 family members stimulate CASP1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59611", "l": "beta-alanyl-L-lysine + H2O <=> beta-alanine + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940388", "l": "GPLD1 hydrolyses GPI-anchors from proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047317", "l": "N6-acetyl-beta-lysine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72714", "l": "cathenamine + H(+) <=> 4,21-dehydrogeissoschizine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0008297", "l": "single-stranded DNA exodeoxyribonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249378", "l": "STING recruits TBK1 and STAT6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610723", "l": "GLI proteins bind SUFU (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797810", "l": "PTPRD binds IL1RAPL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45675", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55583", "l": "ATP + H2O + L-glutamine <=> AMP + 2 H(+) + N(5)-phospho-L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27953", "l": "L-phenylalanine(in) <=> L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990309", "l": "type-II dockerin domain binding", "d": ["Binding to a type-II dockerin domain of a protein. Type-II dockerin domain is the binding partner of type-II cohesin domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685156", "l": "ATR phosphorylates RPA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9866253", "l": "apo-UQCRFS1 binds LYRM7 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23707", "l": "GTP + 4 H2O <=> 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35476", "l": "(1'S,5'S)-5'-hydroxyaverantin + NAD(+) => (S)-5'-oxoaverantin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48015", "l": "4-methyl-5-nitrocatechol + NADPH + O2 <=> 2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76319", "l": "L-aspartate(in) + L-leucine(out) = L-aspartate(out) + L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16535", "l": "H(+) + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + UDP => L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28641", "l": "(-)-gamma-cadinene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52345", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12728", "l": "D-iditol + NAD(+) <=> H(+) + keto-D-sorbose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727749", "l": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033835", "l": "flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: UDP-L-rhamnose + a flavanone 7-O-glucoside = UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60174", "l": "(2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA => 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60472", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656382", "l": "TGFBR2 does not recruit TGFBR1 LBD Mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21518", "l": "piperitenone => isopiperitenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0030249", "l": "guanylate cyclase regulator activity", "d": ["Modulates the activity of guanylate cyclase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046085", "l": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71478", "l": "H2O + neurotensin <=> L-isoleucyl-L-leucine + neurotensin(1-11)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16531", "l": "adenosine 5'-phosphosulfate + phosphate => ADP + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950778", "l": "p-Y693-STAT4 dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209859", "l": "Decarboxylation of 5-hydroxytryptophan forms serotonin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432195", "l": "AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36382", "l": "3-dehydro-4alpha-methylzymosterol + H(+) + NADPH <=> 4alpha-methylzymosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50202", "l": "(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428917", "l": "G13 activation by TP receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944262", "l": "Association of procollagen type X (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791060", "l": "Expression of SRPRB (SRP Receptor subunit beta) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77094", "l": "Formation of cap binding complex (CBC) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33492", "l": "2-hydroxyhexacosanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyhexacosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9840564", "l": "OMA1 hydrolyzes YME1L1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824994", "l": "RPS6KA1-dependent phosphorylation of MITF-M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18698", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) => (4-hydroxyphenyl)acetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449077", "l": "Interleukin-16 is secreted (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17605", "l": "ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine = ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.25", "l": "\"tubulin--tyrosine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388828", "l": "PD-1 binds B7DC and B7H1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41616", "l": "D-ribose 2,5-bisphosphate + H2O = D-ribose 5-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55295", "l": "pseudouridine(54) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76382", "l": "n H(+)(out) + L-histidine(out) <=> n H(+)(in) + L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296244", "l": "SUCNR1 binds SUCCA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62794", "l": "2 H2O + NADP(+) + nigerone => 3 H(+) + NADPH + O2 + 2 rubrofusarin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34648", "l": "S-adenosyl-L-methionine + squalene => 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75908", "l": "ADP-L-glycero-beta-D-manno-heptose + L-seryl-[protein] => ADP + H(+) + O-(L-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606624", "l": "Active FLT3:GRB2 binds GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373074", "l": "Receptor CCR9  binds CCL25 ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.923250621671642", "identifiers": [{"i": "GO:0016635", "l": "oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound."], "t": []}, {"i": "EC:1.3.5.-", "l": "\"With a quinone or related compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905502", "l": "acetyl-CoA binding", "d": ["Binding to acetyl-CoA, an acyl-CoA having acetyl as its S-acetyl component."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76076", "l": "a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out) => a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60671", "l": "(R,R)-chrysanthemol + NAD(+) <=> (1R,3R)-chrysanthemal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25222", "l": "H(+) + L-cysteate => CO2 + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51476", "l": "a ribonucleoside 5'-triphosphate + formate + H(+) = a 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O", "d": [], "t": []}, {"i": "EC:1.1.98.6", "l": "\"ribonucleoside-triphosphate reductase (formate)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034188", "l": "apolipoprotein A-I receptor activity", "d": ["Combining with an apolipoprotein A-I receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74518", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B <=> aspoquinolone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1169192", "l": "PTP1B dephosphorylates GHR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54097", "l": "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9861660", "l": "ME1 tetramer decarboxylates OA to PYR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25590", "l": "(S)-oxalosuccinate + H(+) + NADPH => D-threo-isocitrate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186765", "l": "PLC-gamma binds to the active receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229348", "l": "Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68281", "l": "L-seryl-[protein] + pentanoyl-CoA => CoA + O-pentanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48983", "l": "3,4-dichlorocatechol + O2 <=> (2Z,4Z)-2,3-dichloromuconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49416", "l": "ADP + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + AMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.212", "l": "\"alpha-D-ribose-1-phosphate 5-kinase (ADP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73881", "l": "histamine(in) => histamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76544", "l": "N-acetyl-S-(2-succino)-L-cysteine => fumarate + N-acetyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13576", "l": "[(1->4)-alpha-D-galacturonosyl](n) + UDP-alpha-D-galacturonate <=> [(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65879", "l": "5alpha-androst-1-ene-3,17-dione + H2O <=> 1-hydroxy-5alpha-androstan-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31596", "l": "(Z)-2-methylureidoacrylate + H2O => (Z)-2-methylaminoacrylate + carbamate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11019", "l": "allantoate + H2O <=> (S)-ureidoglycolate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675431", "l": "PP2A dephosphorylates RAF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62176", "l": "GDP-alpha-D-glucose + H2O = alpha-D-glucose 1-phosphate + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11670", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate => [(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75268", "l": "D-arabinose + NADP(+) => D-arabinono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47063", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48524", "l": "a ganglioside GP1c + H2O = a ganglioside GQ1c + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200680", "l": "SLC25A32 transports THF from cytosol to mitochondrial matrix (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72008", "l": "succinate(in) + urate(out) => succinate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25042", "l": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate => L-selenocysteinyl-tRNA(Sec) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840408", "l": "OMA1 cleaves DELE1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47597", "l": "an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy- beta-D-glucuronosyl)-N-acetyl- alpha-D-glucosaminyl phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.12", "l": "\"linoleate 13S-lipoxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26347", "l": "aldehydo-D-galacturonate + H(+) + NADPH => L-galactonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34009", "l": "5-dehydroepisterol + H(+) + S-adenosyl-L-homocysteine => 7-dehydrodesmosterol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24136", "l": "3'-phosphoadenylyl sulfate + a primary amine = a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.3", "l": "\"amine sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60478", "l": "3',3',3'-cAAG + 3 diphosphate => 2 ATP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652264", "l": "ERBB2 binds TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694495", "l": "RTC binds SARS-CoV-2 genomic RNA complement (minus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35857", "l": "1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533965", "l": "NID1 degradation by MMP14, MMP15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686980", "l": "RB1 recruits APC/C:Cdh1 complex to SKP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211983", "l": "CYP2J2 oxidises ARA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33489", "l": "CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64218", "l": "CO2 + L-lyxonate => 2-carboxy-L-lyxonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9757256", "l": "MCM3 binds MCM5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56529", "l": "chloride + D-tryptophan + FADH2 + O2 => 6-chloro-D-tryptophan + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2294574", "l": "Condensin II-mediated condensation of prophase chromosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19208", "l": "dCTP + 2 H2O <=> diphosphate + dUMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5263614", "l": "MeSeOH is reduced to MeSeH by TXNRD1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453342", "l": "PYGM dimer, b form + 2 AMP <=> PYGM b dimer:AMP complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25437", "l": "(2E,6E)-farnesyl diphosphate => (E,R)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36313", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADH => 3,4-dihydroxybenzaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033839", "l": "flavonol-3-O-glycoside glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31752", "l": "chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875816", "l": "STAT3 binds activated MET receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130478", "l": "Interaction of invariant chain trimer and MHC II alpha beta dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031720", "l": "haptoglobin binding", "d": ["Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70211", "l": "2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose = (S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2002440", "l": "Removal of fibrillar collagen C-propeptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909718", "l": "Formation of p-STAT1 homodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6795460", "l": "SGK1 phosphorylates MDM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53077", "l": "cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine => 5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12584", "l": "16alpha-hydroxyprogesterone = 16,17-didehydroprogesterone + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.98", "l": "\"16alpha-hydroxyprogesterone dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41343", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 <=> 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034590", "l": "L-hydroxyproline transmembrane transporter activity", "d": ["Enables the transfer of L-hydroxyproline from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-6784213", "l": "Unknown hydroxyproline carrier transports cytosolic HPRO into the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73699", "l": "ADP(in) + dATP(out) = ADP(out) + dATP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69299", "l": "CDT1 binds geminin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034845", "l": "naphthyl-2-methyl-succinyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: naphthyl-2-methyl-succinyl-CoA = naphthyl-2-methylene-succinyl-CoA + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51991", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O <=> 18S-resolvin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371582", "l": "HSBP1 binds HSF1 trimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24392", "l": "dTDP-L-dihydrostreptose + streptidine 6-phosphate = dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate", "d": [], "t": []}, {"i": "EC:2.4.2.27", "l": "\"dTDP-dihydrostreptose--streptidine-6-phosphate dihydrostreptosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64546", "l": "8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine => acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29817", "l": "ADP + H(+) + L-proline(in) + phosphate => ATP + H2O + L-proline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52706", "l": "D-ribose 5-phosphate + uracil => H2O + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36243", "l": "(E)-anol + acetate + NADP(+) = (E)-coumaryl acetate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985644", "l": "COL1A1 gene expression is stimulated by RUNX2 and RB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1299338", "l": "Activation of TRESK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948136", "l": "ULK1 Translocates to the mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693243", "l": "RHOD translocates to the Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176700", "l": "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047449", "l": "2-dehydro-3-deoxy-L-arabinonate dehydratase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65938", "l": "beta-D-glucose => beta-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818954", "l": "PSIP1 binds MLL1 and MEN1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811479", "l": "ING2 recruits EP300 to TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53784", "l": "beta-muricholate + deoxycholoyl-CoA = beta-muricholoyl-CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858482", "l": "DVL is recruited to the receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162253", "l": "PDSS1,2 ligates FPP to IPPP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418850", "l": "Activation of Cdc42 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052810", "l": "1-phosphatidylinositol-5-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.514861039037328", "identifiers": [{"i": "GO:0000987", "l": "cis-regulatory region sequence-specific DNA binding", "d": ["Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865275", "l": "PDGF-BB clevage by Furin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46172", "l": "ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102709", "l": "S-adenosyl-L-methionine:N,N-dimethyl-beta-alanine N-methyltransferase activity", "d": ["Catalysis of the reaction: N,N-dimethyl-beta-alanine + S-adenosyl-L-methionine = H+ + beta-alanine betaine + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626953", "l": "TNF-α:TNFR1 binds DENN/MADD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32758", "l": "(2S)-naringenin + 2-oxoglutarate + O2 <=> apigenin + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69451", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (-)-delta-cadinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64705", "l": "diphenylmethanol + NAD(+) => benzophenone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34029", "l": "(E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH => 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9687625", "l": "ATP binds MLKL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77360", "l": "2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine => 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.-", "l": "\"Metalloendopeptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39124", "l": "(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O => (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73716", "l": "ATP(in) + dATP(out) => ATP(out) + dATP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10348", "l": "5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate", "d": [], "t": []}, {"i": "EC:3.5.2.9", "l": "\"5-oxoprolinase (ATP-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38738", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-hexadecanoylglycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-2-hexadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003877", "l": "ATP:ADP adenylyltransferase activity", "d": ["Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140997", "l": "histone H4 kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone H4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814120", "l": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19763", "l": "FMN + H2O + NAD(+) => FMN-N(5)-oxide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61498", "l": "an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8863463", "l": "STON2 binds SYT proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45154", "l": "3-oxopropanoyl-CoA + methanethiol => 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047044", "l": "androstan-3-alpha,17-beta-diol dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632887", "l": "TP53 binds the RRM2B gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374173", "l": "AGT(34-41) binds to AGTR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77241", "l": "pseudomonine => pre-pseudomonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39567", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.102", "l": "\"2-alkenal reductase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004439", "l": "phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11845", "l": "acetyl-CoA + formate => CoA + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65343", "l": "acetyl-CoA + L-threonyl-[protein] <=> CoA + O-acetyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16888", "l": "2 (4E,15E)-bilirubin IXalpha C8-beta-D-glucuronoside <=> (4Z,15Z)-bilirubin IXalpha + bilirubin IXalpha bis-beta-D-glucuronoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69000", "l": "3-amino-2,4-dihydroxybenzoate + S-adenosyl-L-methionine = 3-amino-2-hydroxy-4-methoxybenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.380", "l": "\"3-amino-4-hydroxybenzoate 4-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36719", "l": "hexacosenoyl-CoA + sphinganine = CoA + H(+) + N-hexacosenoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56479", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2 <=> (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177479", "l": "Axonal transport of NGF:Trk complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60832", "l": "a 5'-end triphospho-guanosine in mRNA + H2O = a 5'-end diphospho-guanosine in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32944", "l": "a 1,2-diacyl-sn-glycerol + CDP-ethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24327", "l": "6-oxocineole + H(+) + NADPH + O2 <=> 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63921", "l": "octadecanoyl-CoA + sphinga-4E,14Z-dienine => CoA + H(+) + N-octadecanoyl-sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11712", "l": "3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.2.7.7", "l": "\"3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55635", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44912", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (3E)-hexenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660840", "l": "Defective SLC6A5 does not cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350901", "l": "Iodide is organified (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814153", "l": "ADO oxidises 2AET to HTAU (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55682", "l": "anthranilate + H(+) + pyruvate => (2S)-2-amino-4-deoxychorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638127", "l": "PGM1:Mg2+ isomerises G6P to G1P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54152", "l": "a uridine in rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004641", "l": "phosphoribosylformylglycinamidine cyclo-ligase activity", "d": ["Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75083", "l": "ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67228", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA = (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78149", "l": "a 1-acyl-sn-glycerol + a fatty acid + H(+) => a 1,3-diacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174963", "l": "NAT1 acetylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30550", "l": "(3S)-hydroxyhexanoyl-CoA <=> (2E)-hexenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202245", "l": "Phosphorylation of TBSMs in LAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31028", "l": "2-trans-(+)-abscisate + UDP-alpha-D-glucose => beta-D-glucopyranosyl trans-(+)-abscisate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25409", "l": "ADP-alpha-D-glucose + D-glucose => ADP + alpha,alpha-trehalose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45762", "l": "dTDP + H(+) + rhodomycin D => dTDP-beta-L-daunosamine + epsilon-rhodomycinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-205244", "l": "Recruitment of CBL to KIT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36747", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.303", "l": "\"UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-421426", "l": "ProGIP translocates from the ER Lumen to secretory granules (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26557", "l": "angiotensin II + H2O <=> angiotensin-(1-7) + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604712", "l": "Initial activation of proMMP7 by trypsin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9860139", "l": "MIR27B microRNA binds 3'UTR of TGFBR3 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38945", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41585", "l": "dimethylallyl diphosphate + L-tyrosine => 4-O-dimethylallyl-L-tyrosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166220", "l": "FA anion diffuses laterally to UCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60291", "l": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50868", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19279", "l": "AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl) => ATP + L-pyrrolysine + tRNA(Pyl)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65697", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine => a diacylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166271", "l": "IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855648", "l": "SALM3 binds LAR-RPTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050370", "l": "tyrosine N-monooxygenase activity", "d": ["Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112054", "l": "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56150", "l": "CoA + hexadecanoyl-sn-glycero-3-phosphocholine => hexadecanoyl-CoA + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36341", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine => [sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.29", "l": "\"phycobiliprotein cysteine-84 phycobilin lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69434", "l": "3 [thioredoxin]-disulfide + 3 glutathione + 3 H(+) + 3 S-adenosyl-L-homocysteine + trimethylarsine => 3 [thioredoxin]-dithiol + arsenic triglutathione + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851018", "l": "BTN2A1 binds DC-SIGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693783", "l": "NAALADases hydrolyse NAAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50078", "l": "19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19170", "l": "L-serine => NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51471", "l": "(R)-lactate + a quinone <=> a quinol + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21392", "l": "2-phenylacetaldehyde + H2O + NAD(+) = 2-phenylacetate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.39", "l": "\"phenylacetaldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352268", "l": "Cleavage of Satb1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72757", "l": "3',3',3'-c-tri-AMP + 3 diphosphate => 3 ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53751", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose <=> a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-481010", "l": "Surface deployment of platelet dense granule membrane components (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36543", "l": "H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate", "d": [], "t": []}, {"i": "EC:3.5.1.115", "l": "\"mycothiol S-conjugate amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033204", "l": "ribonuclease P RNA binding", "d": ["Binding to RNA subunit of ribonuclease P."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51064", "l": "3'-phosphoadenylyl sulfate + lithocholate = adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18340", "l": "D-ribose 5-phosphate + uracil <=> H2O + psi-UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59916", "l": "(2E)-octenal + H2O + NADP(+) = (2E)-octenoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690785", "l": "BAP1 binds Ub-HCFC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35679", "l": "dodecanoyl-CoA + H(+) + L-serine = 3-oxotetradecasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50363", "l": "(R)-mandelonitrile + O2 <=> benzoyl cyanide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72670", "l": "O2 + reduced [NADPH--hemoprotein reductase] + secologanin <=> 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40492", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65235", "l": "3-hydroxydodecanoyl-CoA + H2O <=> 3-hydroxydodecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74394", "l": "methylamine(out) <=> methylamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41672", "l": "1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53093", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047556", "l": "3,4-dihydroxyphthalate decarboxylase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxyphthalate + H+ = 3,4-dihydroxybenzoate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33813", "l": "6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O => 3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68191", "l": "dodecanoyl-CoA + phytol <=> CoA + dodecanoate phytyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50608", "l": "leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012651", "l": "p-STAT5 dissociates from EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141423", "l": "Binding of the MCC complex to the APC/C complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803063", "l": "RNASEs bind bacterial LPS, PGN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009485", "l": "IL34:CSF1 binds CSF1R (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43137", "l": "guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65430", "l": "deamido-NAD(+)(out) + NAD(+)(in) => deamido-NAD(+)(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3780997", "l": "PPP1R3C binds to glycogen:GYG2:GYS2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388503", "l": "Oxytocin receptor bind oxytocin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33803", "l": "H2O + L-histidinal + NAD(+) = 2 H(+) + L-histidine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357828", "l": "RIPK1 is cleaved by CASP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015313", "l": "fluconazole:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45282", "l": "12-hydroxyoctadecanoate + phosphate => 12-(phosphooxy)octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.261", "l": "\"(4-hydroxyphenyl)alkanoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38356", "l": "(R)-3-phenyllactoyl-CoA => (E)-cinnamoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656893", "l": "OPN1MW binds 11cRAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9854405", "l": "Frataxin transfers Fe2+ to ACO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683831", "l": "CCDC59 binds TTF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47833", "l": "a ganglioside GD1a + H2O => a ganglioside GM1 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75233", "l": "H(+) + L-galactonate => H2O + L-galactono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37286", "l": "H2O + L-alanyl-L-histidine <=> L-alanine + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17352", "l": "(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11799", "l": "ecdysone + O2 <=> 3-dehydroecdysone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34609", "l": "a 1,2-diacyl-sn-glycerol + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0015038", "l": "glutathione disulfide oxidoreductase activity", "d": ["Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor."], "t": []}, {"i": "REACT:R-HSA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3321883", "l": "MSL acetylates histone H4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1358791", "l": "Phosphorylation of USP8 by P-AKT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9695949", "l": "SPHK2 phosphorylates sphingoid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28980", "l": "H(+)(out) + nitrite(in) => H(+)(in) + nitrite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34698", "l": "(2E,6E)-farnesyl diphosphate <=> Delta(6)-protoilludene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45542", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31296", "l": "(2E)-2-hydroxypenta-2,4-dienoate => 2-oxopent-4-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433488", "l": "Phosphorylation of SHP2 by SFKs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196773", "l": "COASY phosphorylates DP-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77284", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16304", "l": "H2O + NAD(+) <=> ADP-D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48839", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62489", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654514", "l": "KAL1 binds FGFR1c (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9710254", "l": "GSDME oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0140659", "l": "cytoskeletal motor regulator activity", "d": ["Binds to and modulates the activity of a motor protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43060", "l": "2-O-(alpha-D-glucopyranosyl)glycerol + phosphate = beta-D-glucose 1-phosphate + glycerol", "d": [], "t": []}, {"i": "EC:2.4.1.332", "l": "\"1,2-alpha-glucosylglycerol phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45489", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit] => (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56940", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13237", "l": "D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.16", "l": "\"glutamine--fructose-6-phosphate transaminase (isomerizing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28575", "l": "H(+)(in) + sulfate(in) => H(+)(out) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623806", "l": "Defective SLC12A6 does not cotransport K+, Cl- from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483186", "l": "PC is converted to PS by PTDSS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66499", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.-.-", "l": "\"Acting on carbon-nitrogen bonds, other than peptide bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55564", "l": "4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27454", "l": "iodide + L-tyrosine + NADP(+) => 3-iodo-L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218847", "l": "PAK2 binds NCK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30631", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate = beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.264", "l": "\"D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol 2-beta-glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035651", "l": "AP-3 adaptor complex binding", "d": ["Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351229", "l": "N-acetylated spermine (cytosol)=>N-acetylated spermine (peroxisomal) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113504", "l": "Detection of damage during initiation of DNA synthesis in S-phase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63955", "l": "a sphingoid 1-phosphate + H2O <=> a sphingoid base + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033454", "l": "GCC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GCC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9711058", "l": "SARS-CoV-1 nsp3 deubiquinates K48-linked pUb IkBA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202375", "l": "Recruitment of ITK to SLP-76 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950456", "l": "IL12B dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76555", "l": "ergosterol + L-aspartyl-tRNA(Asp) = 1-(ergostan-3beta-yl)-L-aspartate + tRNA(Asp)", "d": [], "t": []}, {"i": "EC:2.3.2.37", "l": "\"ergosteryl-3beta-O-L-aspartate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193668", "l": "p75NTR and RHOA-GDI interact (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668714", "l": "RAC1:GTP binds NOX1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018571", "l": "2,3-dihydroxy-p-cumate dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11283", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10436", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.106", "l": "\"bile-acid 7alpha-dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109639", "l": "Formation of the closed pre-initiation complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14396", "l": "N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine <=> 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835385", "l": "DUS2 binds PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451447", "l": "Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21634", "l": "2 1,2-benzoquinone + 2 H2O => 2 catechol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0004104", "l": "cholinesterase activity", "d": ["Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51395", "l": "(9Z)-octadecenoyl-CoA + serotonin <=> CoA + H(+) + N-(9Z-octadecenoyl)-serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840564", "l": "OMA1 hydrolyzes YME1L1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203977", "l": "SAR1 Activation And Membrane Binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50734", "l": "(S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193758", "l": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48918", "l": "a ganglioside GD1c + CMP + H(+) => a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13884", "l": "a quinone + an aldehyde + H2O <=> a carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75824", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] => 5-oxo-(6E,8Z)-octadecadienoate + H(+) + 2 H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78110", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75569", "l": "11-O-acetylcyathatriol + CoA => acetyl-CoA + cyathatriol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21176", "l": "L-idonate + NADP(+) = 5-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44049", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31233", "l": "4-acetamidobutanoate + 2 H(+) + NADH => 4-acetamidobutanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19481", "l": "acetyl-CoA + succinyl-CoA = 3-oxoadipyl-CoA + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.174", "l": "\"3-oxoadipyl-CoA thiolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6804425", "l": "TP53 binds POU4F2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49000", "l": "aurachin C + H(+) + NADH + O2 = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69115", "l": "glyoxylate + L-2-aminoadipate <=> 2-oxoadipate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035133", "l": "NR1H2,3 binds the CETP gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44331", "l": "1-octanoylglycerol + H2O <=> glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266303", "l": "Spherical HDL binds C and E apolipoproteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69060", "l": "N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2 = H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57164", "l": "2-oxoglutarate + L-arginyl-[RCC1 domain-containing protein] + O2 = (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71232", "l": "2 Fe(3+)-[Dph3] + NADH => 2 Fe(2+)-[Dph3] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53872", "l": "CTP + D-ribose 5-phosphate + H(+) = CDP-D-ribose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53647", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-corvol ether B + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.7", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66964", "l": "alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.379", "l": "\"GDP-Man:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352268", "l": "Cleavage of Satb1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12339", "l": "carboxymethoxysuccinate <=> fumarate + glycolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018798", "l": "RHOV binds GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.52", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26052", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] => glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69507", "l": "N-acetyl-D-glucosamine + O2 <=> H2O2 + N-acetyl-D-glucosamino-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53026", "l": "5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+) => a plastoquinone + H2O + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74497", "l": "yaequinolone C => [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168079", "l": "MASTL (GWL) phosphorylates ARPP19 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24541", "l": "A + D-glucose => AH2 + D-glucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27927", "l": "UMP(in) => UMP(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.43", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375138", "l": "CDO binds BOC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1889978", "l": "B3GALT6 transfers Gal to the tetrasaccharide linker (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-178208", "l": "SMAD7 binds to SMURF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37782", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53073", "l": "2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate => 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391939", "l": "TP receptor can bind thromboxane (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018774", "l": "RHOBTB1 binds GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.14.1", "l": "\"yeast ribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665404", "l": "RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50999", "l": "L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64317", "l": "2 dihydrogeodin + 2 H(+) + O2 => 2 (+)-geodin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37411", "l": "aklavinone + NADP(+) = aklaviketone + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.362", "l": "\"aklaviketone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38223", "l": "(9Z)-octadecenoyl-CoA + decan-1-ol = 1-O-decyl-(9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140010", "l": "D-aspartate transmembrane transporter activity", "d": ["Enables the transfer of D-aspartate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6805640", "l": "AKT phosphorylates KAT6A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634834", "l": "ACHEIs bind ACHE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30008", "l": "ATP + H2O + L-arabinose(out) => ADP + H(+) + L-arabinose(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24133", "l": "UDP-alpha-D-galactose => UDP-alpha-D-galactofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21551", "l": "H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] <=> acetate + L-lysyl-[alpha-tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990165", "l": "single-strand break-containing DNA binding", "d": ["Binding to damaged DNA containing single-strand breaks (SSBs)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72001", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II => O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72269", "l": "chloride(in) + formate(out) => chloride(out) + formate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33640", "l": "ATP + CoA + tetracosanoate => AMP + diphosphate + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004066", "l": "asparagine synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.15", "l": "\"desampylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31907", "l": "(S)-norcoclaurine + S-adenosyl-L-methionine = (S)-coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654571", "l": "Activated FGFR1 binds FRS3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004412", "l": "homoserine dehydrogenase activity", "d": ["Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34445", "l": "CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30911", "l": "a sphingomyelin + H2O = a carboxylate + sphing-4-enine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31864", "l": "(S)-2,3-epoxysqualene => friedelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45169", "l": "2 (E)-sinapoyl-CoA + spermidine => 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45794", "l": "[ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate => 2-oxoglutarate + [ribosomal protein S23]-L-proline + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050068", "l": "lysine carbamoyltransferase activity", "d": ["Catalysis of the reaction: L-lysine + carbamoyl phosphate = L-homocitrulline + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428917", "l": "G13 activation by TP receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67522", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432143", "l": "PECAM-1 binds PP2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810376", "l": "ING2 binds PI5P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27386", "l": "H2O + maleamate => maleate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22108", "l": "L-threonine = 2-oxobutanoate + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.19", "l": "\"threonine ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15380", "l": "(S)-4,5-dihydroxypentane-2,3-dione + ATP <=> (2S)-2-hydroxy-3,4-dioxopentyl phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700662", "l": "Liganded-ALK dimer binds type I ALK-binding TKIs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40907", "l": "2 2-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51600", "l": "2 H(+) + m-xylene + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64936", "l": "dGTP + H2O = dGDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120511", "l": "methyl farnesoate epoxidase activity", "d": ["Catalysis of the reaction: methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] = H+ + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49584", "l": "D-erythrulose 1-phosphate = L-erythrulose 1-phosphate", "d": [], "t": []}, {"i": "EC:5.1.3.38", "l": "\"D-erythrulose 1-phosphate 3-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44086", "l": "AMP + diphosphate + heptadecanoyl-CoA => ATP + CoA + heptadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17940", "l": "dihydroxyacetone phosphate <=> methylglyoxal + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11522", "l": "(-)-menthyl beta-D-glucoside + H(+) + UDP => (-)-menthol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682967", "l": "WHSC1 binds DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102121", "l": "ceramidase activity", "d": ["Catalysis of the reaction: H2O + a ceramide = a sphingoid base + a fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211461", "l": "HNF1A-dependent synthesis of the L isoform of PKLR protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57816", "l": "dGMP + H2O = 2-deoxy-D-ribose 5-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77270", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycerol <=> 1,3-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59278", "l": "D-glutamine => L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10878", "l": "CO2 + phenol => 4-hydroxybenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49502", "l": "GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+) => 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77993", "l": "9-(acyloxy)-octadecanoate + a 1-acyl-sn-glycerol => 9-hydroxy-octadecanoate + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684836", "l": "CLEC1B dimer binds PDPN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21811", "l": "2,5-dioxopiperazine + H2O <=> glycylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604763", "l": "Autocatalytic activation of MMP7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664261", "l": "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32752", "l": "choline(out) => choline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672961", "l": "PP2A dephosphorylates inactive RAFs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77663", "l": "1-O-alkyl-3-acylglycerol + an acyl-CoA = 1-O-alkyl-2,3-diacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15335", "l": "H(+) + N-carbamoyl-2-oxoglycine + NADPH => (S)-ureidoglycolate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18169", "l": "4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193653", "l": "NGF homodimer binds to p75NTR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68807", "l": "H2O + kojibiose <=> alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51107", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70519", "l": "(R)-octopamine + S-adenosyl-L-methionine = (R)-synephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613513", "l": "PLINs:HSPA8 binds PRKAA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47247", "l": "(2R)-3-phosphoglycerate + an NDP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46116", "l": "2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689000", "l": "AADAC deacetylates PHEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36179", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18042", "l": "2 H2O + NH4(+) + 6 oxidized [2Fe-2S]-[ferredoxin] => 8 H(+) + nitrite + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873946", "l": "OTUD3 deubiquitinates PTEN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54717", "l": "N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71303", "l": "RPE dimers isomerise RU5P to XY5P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46834", "l": "4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64812", "l": "acetyl-CoA + S-(2-aminoethyl)-homocysteine = CoA + H(+) + S-(2-acetamidoethyl)-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14851", "l": "L-aspartate + urea => H2O + N-amidino-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58139", "l": "acetate + ATP + H(+) <=> acetyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004019", "l": "adenylosuccinate synthase activity", "d": ["Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796617", "l": "MIB2 binds CFLAR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27539", "l": "ethanol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50269", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24802", "l": "2-oxoglutarate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58809", "l": "2',3'-cGAMP + 2 H2O => AMP + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48054", "l": "n adenosine 3',5'-bisphosphate + dermatan 4'-sulfate + n H(+) => n 3'-phosphoadenylyl sulfate + dermatan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29047", "l": "a menaquinone + 2 H(+)(in) + H2 = a menaquinol + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19212", "l": "codeine + NADP(+) <=> codeinone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70247", "l": "N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692315", "l": "OX40L binds OX40 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817940", "l": "Expression of DUXA in the embryo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57552", "l": "[(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60445", "l": "an S-substituted L-cysteinylglycine + H2O => an S-substituted L-cysteine + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27354", "l": "4'-demethylrebeccamycin + S-adenosyl-L-methionine => H(+) + rebeccamycin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662614", "l": "MT1E binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51838", "l": "(9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655142", "l": "RCHY1 binds POLH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18074", "l": "(S)-dihydroorotate + A => AH2 + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40820", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68127", "l": "a 1,2-diacylglycerol + a fatty acyl-[ACP] <=> a triacylglycerol + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9749197", "l": "ORC1 binds to H4K20me2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004963", "l": "follicle-stimulating hormone receptor activity", "d": ["Combining with follicle-stimulating hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050514", "l": "homospermidine synthase (spermidine-specific) activity", "d": ["Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56709", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42153", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine => a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56640", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67630", "l": "(2S)-2-amino-2'-deoxyadenylo-succinate + ADP + 2 H(+) + phosphate => ATP + dGMP + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51355", "l": "H2O + N-(9Z-octadecenoyl)-L-serine <=> (9Z)-octadecenoate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30401", "l": "alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68872", "l": "(E)-cinnamate + ATP + H(+) + NADPH = (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.21", "l": "\"maltose epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4086410", "l": "CDK1 phosphorylates BORA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40249", "l": "10-carboxy-13-deoxycarminomycin + H(+) + methanol => H2O + rhodomycin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707690", "l": "BACH1 binds MAFK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632652", "l": "Hh-Npp binds CDON and PTCH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578777", "l": "DMPK phosphorylates PLN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14459", "l": "3-propylmalate + CoA + H(+) => glyoxylate + H2O + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79129", "l": "L-phenylalanocholate + taurine => L-phenylalanine + taurocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39919", "l": "1-O-(alk-1-enyl)-sn-glycero-3-phosphate + H2O = 1-O-(alk-1-enyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37382", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36951", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2 = (9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64918", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphate => a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985343", "l": "RUNX2 binds SOX9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65129", "l": "1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.54", "l": "\"mucrolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013869", "l": "DDX41 binds bacterial c-di-AMP, c-di-GMP   (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67053", "l": "AH2 + asnovolin J + O2 => A + asnovolin A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58143", "l": "acetyl-AMP + cytidine(34) in elongator tRNA(Met) <=> AMP + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586559", "l": "Leptin Binds Leptin Receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46653", "l": "epitestosterone + H(+) + NADPH => 5beta-dihydroepitestosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69730", "l": "2-phenylacetate + ATP + H(+) <=> diphosphate + phenylacetyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420233", "l": "VIP receptors bind VIP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.2.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.17", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15084", "l": "acetate + ATP + CoA <=> acetyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009032", "l": "thymidine phosphorylase activity", "d": ["Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44571", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) <=> 2-all-trans-hexaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65837", "l": "AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O => A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68954", "l": "Mcm2-7 is phosphorylated by DDK (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77792", "l": "an N-(1-deoxy-beta-D-fructopyranos-1-yl)amine + O2 => an (E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amine + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37206", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.148", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34964", "l": "Na(+)(in) => Na(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.96", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16904", "l": "acetyl-CoA + L-2,4-diaminobutanoate <=> (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78517", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62594", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (S)-8-oxocitronellyl enol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781897", "l": "USP11 deubiquitinates NFKBIA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981093", "l": "IL12 bound to IL12R internalises (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2328037", "l": "Fibrillin-1 binds integrins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362427", "l": "Hh-Np binds GPC5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928583", "l": "FYN phosphorylates NMDAR2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74120", "l": "delphinidin + UDP-alpha-D-galactose => delphinidin 3-O-beta-D-galactoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65981", "l": "hnu + previtamin D3 => tachysterol 3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33106", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-muurolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10616", "l": "(2R,3S)-catechin + H2O + NADP(+) = (2R,3S,4S)-leucocyanidin + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.17.1.3", "l": "\"leucoanthocyanidin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11295", "l": "2 H(+) + O2 + rifamycin B <=> H2O2 + rifamycin O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31173", "l": "(2E)-tetradecenoyl-CoA + H2O => (3S)-hydroxytetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63477", "l": "NADP(+) + prostaglandin E2 => 15-oxoprostaglandin E2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76180", "l": "a dipeptide(out) + 2 H(+)(out) => a dipeptide(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351849", "l": "Caspase-mediated cleavage of Etk (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36359", "l": "2 a plastoquinone + 2 H2O + 4 hnu = 2 a plastoquinol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813626", "l": "LEAP2 binds bacteria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65624", "l": "hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine = CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140801", "l": "histone H2AXY142 kinase activity", "d": ["Catalysis of the reaction: histone H2AX-tyrosine (position 142) + ATP = (histone H2AX-phosphotyrosine (position 142) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 142 of histone variant H2AX."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74869", "l": "(E)-caffeoyl-CoA + H(+) + NADPH => (E)-caffeyl aldehyde + CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57685", "l": "4-hydroxyestrone + NH4(+) + O2 => 2 H(+) + 2 H2O + pyridinestrone carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549279", "l": "OCT2 mediates tubular uptake of organic cations in the kidney (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15698", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047082", "l": "3,9-dihydroxypterocarpan 6a-monooxygenase activity", "d": ["Catalysis of the reaction: (6aR,11aR)-3,9-dihydroxypterocarpan + H+ + NADPH + O2 = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H2O + NADP+. (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2214351", "l": "PLK1 phosphorylates GORASP1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033509", "l": "USP9X binds Ub:PEX5L (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852874", "l": "CR2 binds C3d, C3dg, iC3b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.203", "l": "\"tRNA (cytosine(34)-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004751", "l": "ribose-5-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2214351", "l": "PLK1 phosphorylates GORASP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836404", "l": "p-PKR dimer phosphorylates MAPT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24031", "l": "2-oxoglutarate + 4-(trimethylamino)butanoate + O2 <=> carnitine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70840", "l": "L-arginine(in) + L-histidine(out) + Na(+)(out) => L-arginine(out) + L-histidine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209303", "l": "LGS transports from the nucleus to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9906042", "l": "TTC19 clears UQCRFS1 fragments from Complex III (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52092", "l": "5-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54222", "l": "all-trans-neurosporene + H2O => 1-hydroxy-all-trans-1,2-dihydro-neurosporene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51981", "l": "an L-N,N-dihydroxypolyhomomethionine + H(+) => an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50433", "l": "AH2 + prostaglandin G1 => A + H2O + prostaglandin H1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102198", "l": "L-idonate 5-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: L-idonate + NAD+ = 5-dehydro-D-gluconate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606784", "l": "Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734687", "l": "ORC6 is phosphorylated on T195 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483219", "l": "PC is exchanged with PI by PITPNB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097262", "l": "eoxin D4 synthase activity", "d": ["Catalysis of the reaction: eoxin C4 = eoxin D4 + 5-L-glutamyl amino acid."], "t": []}, {"i": "REACT:R-HSA-2161945", "l": "EXC4 is converted to EXD4 by GGT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50113", "l": "octadecanoyl-CoA + taurine => CoA + H(+) + N-octadecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205115", "l": "NGF:p75NTR complex binds to NRAGE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28120", "l": "D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP => di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205136", "l": "GTP-bound RAC contributes to JNK activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972967", "l": "POU5F1 (OCT4), SOX2, NANOG bind the EPHA1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67112", "l": "L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52423", "l": "O-phospho-L-serine + thiosulfate <=> phosphate + S-sulfo-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60476", "l": "2 ATP + GTP = 3',3',3'-cAAG + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373071", "l": "Receptor CCR7 binds CCL19 and 21 ligands (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48368", "l": "beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer + GDP-beta-L-fucose = beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004500", "l": "dopamine beta-monooxygenase activity", "d": ["Catalysis of the reaction: L-ascorbate + dopamine + O2 = (R)-noradrenaline + dehydroascorbate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45500", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34768", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O => (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41866", "l": "decanoyl-[ACP] + NADP(+) => (2E)-decenoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68036", "l": "(S)-cystathionine ketimine + 2 H(+) + NADPH = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77343", "l": "N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27818", "l": "L-idonate + NAD(+) = 2-dehydro-L-idonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38432", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O => (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010646", "l": "AKAP5 recruits PKC to ROBO3.1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0070224", "l": "sulfide:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: H2S (hydrogen sulfide) + a quinone = S0 (sulfane sulfur) + a hydroquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004595", "l": "pantetheine-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714481", "l": "RAC2 binds effectors at the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655844", "l": "Expression of Squalene Monooxygenase (SQLE) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38431", "l": "1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = (9Z)-octadecenoate + 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79099", "l": "cholate + L-histidine = H2O + L-histidocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951951", "l": "RUNX3 binds EP300 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391942", "l": "IP receptor can bind prostacyclin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22698", "l": "A + H2O + testololactone => AH2 + androst-4-ene-3,17-dione + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68041", "l": "(R)-lanthionine ketimine + 2 H(+) + NADPH => (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008785", "l": "alkyl hydroperoxide reductase activity", "d": ["Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29807", "l": "ATP + H2O + L-leucine(out) = ADP + H(+) + L-leucine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086393", "l": "G alpha t2 binds and activates PDE6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2002428", "l": "Removal of fibrillar collagen N-propeptides (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58900", "l": "1-carboxybiuret + H2O = NH4(+) + urea-1,3-dicarboxylate", "d": [], "t": []}, {"i": "EC:3.5.1.131", "l": "\"1-carboxybiuret hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56662", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH => 7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64973", "l": "dUDP + H2O => dUMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56213", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.44", "l": "\"alanine--glyoxylate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.35", "l": "\"dimethylsulfone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59851", "l": "(2R,3S)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH <=> (S)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59984", "l": "an N(2)-acyl-L-glutamine + H2O = a carboxylate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400219", "l": "Beta-TrCP1 binds phosphorylated PER proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003949", "l": "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity", "d": ["Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66352", "l": "(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD(+) = (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23678", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45116", "l": "(4R)-ipsdienol + NADP(+) = H(+) + ipsdienone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110360", "l": "Recruitment of POLB to the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399934", "l": "Phosphorylation of Plexin-A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71387", "l": "L-pipecolate(in) + Na(+)(in) = L-pipecolate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21374", "l": "CO2 + ethanol + NH4(+) => H(+) + H2O + urethane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31579", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate", "d": [], "t": []}, {"i": "EC:5.4.4.5", "l": "\"9,12-octadecadienoate 8-hydroperoxide 8R-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209221", "l": "Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53161", "l": "H2O + N-acyl-sn-glycero-3-phosphoethanolamine => an N-acylethanolamine + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78190", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine <=> a 1-acyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36905", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine => 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52074", "l": "(9Z)-hexadecenoate + 12-hydroxyoctadecanoate + H(+) => 12-(9Z-hexadecenoyloxy)-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30867", "l": "H2O + indole-3-acetaldehyde + NAD(+) = (indol-3-yl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0015199", "l": "amino-acid betaine transmembrane transporter activity", "d": ["Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174224", "l": "Dissociation of Cdc20 from APC/C complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47883", "l": "dioctanoylglycerol + H2O <=> H(+) + octanoate + octanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52349", "l": "(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate => (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004482", "l": "mRNA 5'-cap (guanine-N7-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390438", "l": "FAR2 reduces PalmCoA to HXOL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418436", "l": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177926", "l": "Dephosphorylation of PAG by SHP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19901", "l": "L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2", "d": [], "t": []}, {"i": "EC:1.3.3.10", "l": "\"tryptophan alpha,beta-oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944227", "l": "Association of procollagen type XXII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004658", "l": "propionyl-CoA carboxylase activity", "d": ["Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67245", "l": "3-deoxyglucosone + H2O + NAD(+) => 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139893", "l": "Granzyme-B activates BID by cleavage (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35932", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-glucose => 3''-deamino-3''-hydroxykanamycin X + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63484", "l": "2-oxoglutarate + L-prolyl-[protein] + O2 = CO2 + succinate + trans-4-hydroxy-L-prolyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54840", "l": "H(+) + NADPH + O2 + octan-3-one = H2O + NADP(+) + pentyl propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0042876", "l": "aldarate transmembrane transporter activity", "d": ["Enables the transfer of aldarate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016428", "l": "tRNA (cytidine-5-)-methyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H+. This modification can occur on seversal residues, including cytidine(34), cytidine(40), cytidine(48), and cytidine(49)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9736970", "l": "WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018785", "l": "RHOBTB2 binds GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38697", "l": "a cardiolipin(out) => a cardiolipin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-266072", "l": "LTA4 is hydolysed to LTB4 by LTA4H (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20370", "l": "betaine aldehyde + H2O + O2 => glycine betaine + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42608", "l": "a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061503", "l": "tRNA threonylcarbamoyladenosine dehydratase", "d": ["Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649736", "l": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607721", "l": "Activation of NIK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390929", "l": "HTR1 and 5A receptors can bind serotonin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798372", "l": "ATM phosphorylates DYRK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50834", "l": "17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36001", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33656", "l": "(9Z)-octadecenoate(out) => (9Z)-octadecenoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009028", "l": "tartronate-semialdehyde synthase activity", "d": ["Catalysis of the reaction: 2 glyoxylate + H+ = 2-hydroxy-3-oxopropanoate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-170120", "l": "Translocation of Cdc25B to the cytoplasm (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.4", "l": "\"Xaa-Arg dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58758", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61580", "l": "(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) = (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68071", "l": "a 14alpha-formyl steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a Delta(14) steroid + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788611", "l": "HYKK phosphorylates 5HLYS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31632", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate => phosphate + pseudaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42093", "l": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71725", "l": "H(+)(in) + L-alanyl-L-leucyl-L-alanine(in) => H(+)(out) + L-alanyl-L-leucyl-L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16385", "l": "4-hydroxybenzoate + 2 H(+) + NADPH + O2 = CO2 + H2O + hydroquinone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34225", "l": "2,6-dihydroxypseudooxynicotine + AH2 => 6-hydroxypseudooxynicotine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43375", "l": "an N-acylsphing-4-enine + dTDP-alpha-D-glucose <=> a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57023", "l": "apulose + ATP <=> ADP + apulose 4-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9035484", "l": "CysS248-MPST:TXN2 dissociates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16186", "l": "an aldehyde + H2O + NAD(+) => a carboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12365", "l": "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) => a quinol + beta-nicotinamide D-riboside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40481", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52026", "l": "18S-resolvin E2 + A + H2O => (5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22806", "l": "(6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH => (6S,9R)-vomifoliol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004945", "l": "angiotensin type II receptor activity", "d": ["An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13633", "l": "ATP + L-glutamate + putrescine = ADP + gamma-L-glutamylputrescine + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.1.11", "l": "\"glutamate--putrescine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48149", "l": "ganglioside GT1b (d18:1(4E)/18:0) + H2O => ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63411", "l": "6-chloropyridine-2,3,5-triol + FADH2 + O2 <=> 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41784", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA1 (d18:1(4E)/18:0) = CMP + ganglioside GM1 (d18:1(4E)/18:0) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474196", "l": "Collagen type II degradation by MMP14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16411", "l": "H(+) + NADPH + vomilenine => 1,2-dihydrovomilenine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62511", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004077", "l": "biotin-[acetyl-CoA-carboxylase] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202110", "l": "eNOS:Caveolin-1 complex binds to CaM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65088", "l": "asperaculane E + O2 + reduced [NADPH--hemoprotein reductase] = asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451505", "l": "Dissociation of phospho ERK2 :phospho MEK2 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63476", "l": "NADP(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51302", "l": "H2O + N-(9Z-octadecenoyl)-L-phenylalanine => (9Z)-octadecenoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047735", "l": "cellobiose dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31334", "l": "ATP + H(+) + molybdopterin <=> adenylyl-molybdopterin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47761", "l": "a uridine in 21S rRNA + S-adenosyl-L-methionine => a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822591", "l": "TET3 binds chromatin with H3K17me2a and 5-mC:METTL23:STGP4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683888", "l": "LMCD1 binds GATA6, sequestering it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74152", "l": "acetyl-CoA + L-lysyl-[beta-tubulin] => CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034581", "l": "4-methyloct-2-enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48750", "l": "D-erythrulose + H(+) + NADH => D-threitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40204", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400143", "l": "Fatty acid ligands activate PPARA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51335", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.1", "l": "\"alpha-amylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53063", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate <=> estrone 4-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15775", "l": "ADP + dihydroxyacetone phosphate + H(+) => ATP + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68211", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + 1,2-dihexanoylglycerol <=> 1,2-dihexanoyl-3-(7Z,10Z,13Z-hexadecatrienoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24558", "l": "5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH => 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43277", "l": "a ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine => a ganglioside GalNAc-GD1a + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55691", "l": "an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + H2O <=> 1D-myo-inositol 1-phosphate + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.942687253280909", "identifiers": [{"i": "GO:0005342", "l": "organic acid transmembrane transporter activity", "d": ["Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798749", "l": "Exocytosis of specific granule lumen proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65216", "l": "3-oxododecanoyl-CoA + H2O = 3-oxododecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25048", "l": "(2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+) => (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9708275", "l": "PDE4A binds PDE4A inhibitors (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35949", "l": "chanoclavine-I aldehyde + H(+) + NADPH => dihydrochanoclavine-I aldehyde + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18951", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha,13alpha-diol => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.003228521996348", "identifiers": [{"i": "GO:0016706", "l": "2-oxoglutarate-dependent dioxygenase activity", "d": ["Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9655046", "l": "Cleavage of FXII variant by KLKB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70518", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-galactose <=> 3-O-(beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-alpha-L-Fuc)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44417", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29155", "l": "2 H(+)(out) + nitrite(out) + 3 ubiquinol-8(in) = 2 H2O(out) + NH4(+)(out) + 3 ubiquinone-8(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72631", "l": "Formation of the cap-binding eIF4F complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008403", "l": "25-hydroxycholecalciferol-24-hydroxylase activity", "d": ["Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18944", "l": "a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) <=> a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53347", "l": "5,6-dihydrouridine(20a) in tRNA + NADP(+) <=> H(+) + NADPH + uridine(20a) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42835", "l": "(2E)-octenal + H(+) + pyruvate <=> (S)-3-acetyloctanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159803", "l": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853444", "l": "AURKA phosphorylates PHLDA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981926", "l": "RAC1 and CDC42 activate PAK3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56382", "l": "(4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 FAD + 4 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 chloride + 2 FADH2 + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34532", "l": "acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose => CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43472", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37746", "l": "dimethylallyl phosphate + FMNH2 <=> phosphate + prenyl-FMNH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11078", "l": "catechol + CO2 + NAD(+) + NH4(+) => anthranilate + 3 H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17407", "l": "H(+) + N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine => N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390649", "l": "CHRM1,3,5 bind acetylcholine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19907", "l": "dehydrospermidine + H(+) + NADH => NAD(+) + spermidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.3", "l": "\"mitochondrial protein-transporting ATPase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26281", "l": "Co-precorrin-5A + H2O = acetaldehyde + Co-precorrin-5B + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.12", "l": "\"cobalt-precorrin 5A hydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73499", "l": "3',4',7-trihydroxyflavone + S-adenosyl-L-methionine = 4',7-dihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689544", "l": "UCHL5 binds INO80 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56903", "l": "a globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine <=> a globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210805", "l": "Removal of miRNA passenger strand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36088", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13813", "l": "benzene + H(+) + NADH + O2 = cis-1,2-dihydrobenzene-1,2-diol + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.3", "l": "\"benzene 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75650", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (8R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45389", "l": "H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842850", "l": "TRIM28 (KAP1) binds KRAB-ZFP in KRAB-ZFP:retroelement chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1297275", "l": "CD9:Izumo Binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22311", "l": "O2 + xylitol <=> D-xylose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28306", "l": "beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose = beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.251", "l": "\"GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 4-beta-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034006", "l": "amorpha-4,11-diene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071861", "l": "tachykinin receptor binding", "d": ["Binding to a tachykinin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853529", "l": "OTULIN,USP5 cleaves UBB yielding ubiquitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789042", "l": "Hydroxyl-initiated lipid peroxidation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17443", "l": "2-oxo-3-sulfanylpropanoate + L-glutamate => 2-oxoglutarate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2484822", "l": "Kinetochore assembly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21172", "l": "L-idonate + NAD(+) = 5-dehydro-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39363", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA = (2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37341", "l": "(R)-3-amino-2-methylpropanoate + CO2 + NH4(+) => 3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41683", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) <=> a 2-all-trans-polyprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71856", "l": "taurochenodeoxycholate(out) => taurochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51704", "l": "S-adenosyl-L-methionine + xanthohumol = 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.339", "l": "\"xanthohumol 4-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9615249", "l": "ARBs bind AGRT1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20789", "l": "NAD(+) + phosphate => ADP-alpha-D-ribose 1''-phosphate + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25739", "l": "N-hydroxy-L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54876", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = (3S)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14407", "l": "D-glucono-1,5-lactone + H(+) + NADPH => D-glucose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35757", "l": "H(+) + NADH + UDP-3-oxo-alpha-D-glucose => NAD(+) + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9649735", "l": "Intrinsic nucleotide exchange on RAS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78381", "l": "CoA + S-nitroso-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-nitroso-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75051", "l": "chenodeoxycholate(out) = chenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23689", "l": "adenine + H(+) + H2O => hypoxanthine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30713", "l": "beta-myrcene + H2O => (S)-linalool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0019202", "l": "amino acid kinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018788", "l": "atrazine chlorohydrolase activity", "d": ["Catalysis of the reaction: atrazine + H2O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39459", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36766", "l": "alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871260", "l": "YAP1 binds TEAD2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190245", "l": "FGFR1b binds to FGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042959", "l": "ABC-type alkanesulfonate transporter transporter activity", "d": ["Enables the transfer of an alkanesulfonate from one side of a membrane to the other according to the reaction: ATP + H2O + alkanesulfonate(out) = ADP + phosphate + alkanesulfonate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102592", "l": "delphinidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent activity", "d": ["Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose = violdelphin + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.17", "l": "\"enoyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43840", "l": "26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201521", "l": "ALK autophosphorylation  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5665871", "l": "ADRM1 binds 26S proteasome (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65297", "l": "(2R)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50133", "l": "ethyl hexadecanoate + H2O => ethanol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76052", "l": "Binding of TFIIIA To type 1 Promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12057", "l": "D-erythrose 4-phosphate + H2O + NAD(+) => 4-phospho-D-erythronate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674022", "l": "BRAP autoubiquitinates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8957241", "l": "TP73 tetramer translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952137", "l": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012835", "l": "GDIs block activation of RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610752", "l": "GLI3R translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748991", "l": "XDH oxidises 6MP to 6TU (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811412", "l": "Active ARF recruits coatomer to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75254", "l": "carminate + O2 <=> 3'-dehydrocarminate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71077", "l": "L-arginine(out) + L-cystine(in) => L-arginine(in) + L-cystine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35657", "l": "3',3'-c-di-AMP + 2 diphosphate => 2 ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67877", "l": "3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine => 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173636", "l": "Formation of classic pathway C5 convertase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.042693372152272", "identifiers": [{"i": "GO:0046992", "l": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y."], "t": []}, {"i": "EC:1.21.-.-", "l": "\"Catalyzing the reaction X-H + Y-H = 'X-Y'\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78496", "l": "acetyl-CoA + CMP-5'-(N-hydroxy-3-aminopropyl)phosphonate => CMP-5'-(N-acetyl-N-hydroxy-3-aminopropyl)phosphonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043815", "l": "phosphoribosylglycinamide formyltransferase 2 activity", "d": ["Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222363", "l": "MsrA/B reduces peptide-methionine S/R-sulfoxides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167133", "l": "Activation of GT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79078", "l": "(4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside + UDP-alpha-D-glucuronate <=> (4Z,15Z)-bilirubin IXalpha C8,C12-beta-D-bisglucuronoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0005034", "l": "osmosensor activity", "d": ["Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169680", "l": "IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.15", "l": "\"3-(aryl)acrylate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48167", "l": "epoxypheophorbide a + H2O <=> H(+) + red chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24490", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34850", "l": "7,8-dihydromonapterin + H(+) + NADPH <=> 5,6,7,8-tetrahydromonapterin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3858506", "l": "Defective GYS2 does not transfer glucose to growing glycogen chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33774", "l": "a 1,2-diacyl-sn-glycerol + CDP-N-methylethanolamine <=> 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071164", "l": "RNA cap trimethylguanosine synthase activity", "d": ["Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163770", "l": "Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27677", "l": "ATP + dADP <=> ADP + dATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687097", "l": "p-S857 NCOA3 binds ETV4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27476", "l": "ATP + D-glycero-beta-D-manno-heptose 7-phosphate <=> ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21797", "l": "dTDP-beta-L-rhamnose + NADP(+) => dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50255", "l": "an acyl-CoA + H(+) + malonyl-CoA <=> a 3-oxoacyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61699", "l": "ATP + glycine + holo-[peptidyl-carrier protein] <=> AMP + diphosphate + glycyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15119", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine => 3'-dephospho-CoA + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63936", "l": "3 a ubiquinone + protoporphyrinogen IX = 3 a ubiquinol + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034789", "l": "2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + phthalate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68611", "l": "Formation of ORC(1-5) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39116", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) => 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623072", "l": "POMC gene expression is inhibited by FOXO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809238", "l": "MTMR7 binds MTMR9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.25", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62847", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36752", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => beta-D-Gal-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72997", "l": "L-fucose(in) + 2 Na(+)(in) => L-fucose(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549129", "l": "OCT1 transports organic cations into hepatic cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420688", "l": "GABAB heterodimeric receptor binds GABA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9736953", "l": "FURIN translocates to the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31618", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine <=> dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001039", "l": "RNA polymerase III hybrid type promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.1.-", "l": "\"Sulfurtransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51553", "l": "D-sorbitol + NADP(+) => H(+) + L-xylo-3-hexulose + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37063", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40178", "l": "O2 + octanoyl-CoA <=> (2E)-octenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061769", "l": "ribosylnicotinate kinase activity", "d": ["Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H+ + nicotinate mononucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20029", "l": "10-deoxysarpagine + NADP(+) = H(+) + NADPH + vellosimine", "d": [], "t": []}, {"i": "EC:1.1.1.273", "l": "\"vellosimine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30903", "l": "demethylspheroidene + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + spheroidene", "d": [], "t": []}, {"i": "EC:2.1.1.210", "l": "\"demethylspheroidene O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199131", "l": "PVR binds CD226 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168888", "l": "Alpha1-Microglobulin binds heme (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22587", "l": "2 H(+) + heme b <=> Fe(2+) + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013009", "l": "RHOA binds effectors at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77885", "l": "D-ribulose 1-phosphate + phosphate => D-ribulose 1,5-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16022", "l": "oxaloacetate => enol-oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50853", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043422", "l": "protein kinase B binding", "d": ["Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27576", "l": "(3R)-piperidine-3-carboxylate + NH4(+) => (3R)-piperidine-3-carboxamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684836", "l": "CLEC1B dimer binds PDPN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68419", "l": "cis-(homo)2aconitate + H2O <=> (2R,3S)-iso(homo)2citrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002440", "l": "Removal of fibrillar collagen C-propeptides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55489", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824216", "l": "MSGN1 binds the NOTCH1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362386", "l": "Glycosylation of Hh (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68623", "l": "cortisone + H(+) + NADPH <=> 20beta-dihydrocortisone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.5", "l": "\"short-chain 2-methylacyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836404", "l": "p-PKR dimer phosphorylates MAPT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66783", "l": "6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine + H2O <=> N-acetyl-D-glucosamine + N-acetyl-D-muramate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66280", "l": "solanidine + UDP-alpha-D-glucose = H(+) + solanidine 3-O-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865237", "l": "SETD6 methylates RELA in the NFkB complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30063", "l": "2-demethylmenaquinol-8 + S-adenosyl-L-methionine = H(+) + menaquinol-8 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37487", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphocholine = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44913", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH => (3E)-hexenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2752115", "l": "SPP1 (osteopontin) binds CD44 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51549", "l": "(S)-tetrahydropapaverine + S-adenosyl-L-methionine => (S)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38322", "l": "chorismate + H2O <=> (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63907", "l": "2 3-phenylpyruvate + H(+) <=> H2O + phenguignardate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70262", "l": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141341", "l": "SMOX-3 oxidises SPN to SPM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27755", "l": "H2O + methylglyoxal => (R)-lactate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110319", "l": "Elongation by POLH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449978", "l": "IL7 binds IL7R:JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696958", "l": "USP44 deubiquitinates CDC20 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954082", "l": "E2F6 binds the PRC1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27933", "l": "(R)-4-phosphopantoate + ATP + beta-alanine <=> (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102138", "l": "7-oxatyphasterol synthase activity", "d": ["Catalysis of the reaction: H+ + typhasterol + NADPH + O2 = 7-oxatyphasterol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462014", "l": "Alpha-defensins form biologically active dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047083", "l": "5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371435", "l": "Constitutive phosphorylation by GSK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46522", "l": "an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O => an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38922", "l": "H2O + sphing-4-enine-phosphocholine <=> choline + H(+) + sphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36225", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42676", "l": "L-cysteine + L-histidine + O2 = H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide", "d": [], "t": []}, {"i": "EC:1.14.99.52", "l": "\"L-cysteinyl-L-histidinylsulfoxide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213246", "l": "Disassociation of CLIP from MHC II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46770", "l": "a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42893", "l": "5'-deoxyadenosine + H(+) + H2O => 5'-deoxyinosine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23157", "l": "(E)-(indol-3-yl)acetaldehyde oxime => (indol-3-yl)acetonitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67594", "l": "(R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+) => a 5'-end CoA-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59805", "l": "L-phenylalanine => D-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29088", "l": "(S)-malate + menaquinone-8 => menaquinol-8 + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001540", "l": "amyloid-beta binding", "d": ["Binding to an amyloid-beta peptide/protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17324", "l": "L-tryptophan + S-adenosyl-L-methionine <=> 2-methyl-L-tryptophan + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68875", "l": "(E)-cinnamate + ATP + H(+) + NADPH <=> (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9864415", "l": "AAC1 imports a proton (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33683", "l": "H(+) + L-serine + octadecanoyl-CoA = 3-oxoeicosasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019970", "l": "interleukin-11 binding", "d": ["Binding to interleukin-11."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74162", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50500", "l": "acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71913", "l": "cholate(in) + 2 Na(+)(in) => cholate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21088", "l": "2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 = a flavonol + CO2 + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.6", "l": "\"flavonol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43234", "l": "H(+) + isatinate => H2O + isatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66668", "l": "5-methylorsellinate + O2 + reduced [NADPH--hemoprotein reductase] = 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52844", "l": "3,4-dihydroxybenzoate + UDP-alpha-D-glucose = 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57697", "l": "ATP + cob(I)inamide-[corrinoid adenosyltransferase] => adenosylcob(III)inamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047762", "l": "caffeate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: trans-caffeate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199169", "l": "MHC Class I interacts with CD160 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296045", "l": "Activation of Potassium transport channels (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180017", "l": "K11-linked deubiquitinase activity", "d": ["Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys11 residue of ubiquitin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28228", "l": "capsidiol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-5-epi-aristolochene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9853372", "l": "FIRRM binds PPP1CC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53182", "l": "D-erythrulose => D-erythrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44985", "l": "(R)-carnitine + 3-methylbutanoyl-CoA => CoA + O-3-methylbutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9759158", "l": "SQSTM1 oligomerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47469", "l": "(2E,4E)-tetradecadienoyl-CoA => (3E,5Z)-tetradecadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45529", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433454", "l": "Phosphorylation of GAB2 by SFKs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39978", "l": "2-iminobutanoate + H2O <=> 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0005200", "l": "structural constituent of cytoskeleton", "d": ["The action of a molecule that contributes to the structural integrity of a cytoskeletal structure."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23944", "l": "(E)-coniferol + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-(E)-coniferol + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.111", "l": "\"coniferyl-alcohol glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.98.1.-", "l": "\"Other oxidoreductases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114254", "l": "CYCS binds to APAF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612246", "l": "ERBB4s80 binds the APOE gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2562526", "l": "PLK1 phosphorylates OPTN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655170", "l": "RCHY1 monoubiquitinates POLH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43627", "l": "2-aminomalonate semialdehyde + H(+) <=> aminoacetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350769", "l": "trans-Golgi Network Coat Activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18596", "l": "sphinganine 1-phosphate <=> hexadecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42463", "l": "dibenzofuran + H(+) + NADH + O2 <=> biphenyl-2,2',3-triol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40602", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3899291", "l": "SUMOylation of EP300 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39814", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102480", "l": "5-fluorocytosine deaminase activity", "d": ["Catalysis of the reaction: H+ + flucytosine + H2O = 5-fluorouracil + ammonium."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.-", "l": "\"Endopeptidases of unknown catalytic mechanism\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12886", "l": "GDP-alpha-D-mannose + queuosine(34) in tRNA(Asp) => GDP + H(+) + O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44471", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol <=> a 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52195", "l": "(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] <=> (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30326", "l": "all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17681", "l": "3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59868", "l": "4-(2,4-dichlorophenoxy)butanoate + ATP + L-glutamine = 4-(2,4-dichlorophenoxy)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450984", "l": "IDH2 dimer decarboxylates isocitrate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805620", "l": "KAT6A and PML bind TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730886", "l": "Phosphorylation of SHC by SYK kinase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700149", "l": "Active ALK binds PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68453", "l": "all-trans-10'-apo-beta-carotenal + O2 => 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70406", "l": "(9Z)-hexadecenoyl-CoA + 3-oxosphinganine <=> CoA + H(+) + N-(9Z-hexadecenoyl)-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45632", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28276", "l": "(R)-S-adenosyl-L-methionine => (S)-S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25655", "l": "aminoacetone + CO2 => (2S)-2-amino-3-oxobutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78218", "l": "D-glutamine + H2O + O2 <=> 2-oxoglutaramate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17503", "l": "16-epivellosimine + CO2 + methanol => H2O + polyneuridine aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451535", "l": "Dimerization of activated ERK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28922", "l": "4-aminobutanoate(in) + L-glutamate(out) <=> 4-aminobutanoate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11077", "l": "anthranilate + 3 H(+) + NADH + O2 => catechol + CO2 + NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071886", "l": "1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding", "d": ["Binding to the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9854672", "l": "FAD attaches to SDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48903", "l": "chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944246", "l": "Association of procollagen type XXI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32916", "l": "sn-glycero-3-phospho-1D-myo-inositol(out) => sn-glycero-3-phospho-1D-myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937134", "l": "miR-27a binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874083", "l": "p-Y397-PTK2 binds SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004917", "l": "interleukin-7 receptor activity", "d": ["Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32269", "l": "glycine + succinate semialdehyde => 4-aminobutanoate + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371435", "l": "Constitutive phosphorylation by GSK3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380508", "l": "Translocation of NuMA to the centrosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68902", "l": "4-methoxybenzaldehyde + AMP + diphosphate + NADP(+) => 4-methoxybenzoate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46284", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9861640", "l": "CTLH E3 ligase ubiquitinates PKM-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "56.094519958262133", "identifiers": [{"i": "GO:0140640", "l": "catalytic activity, acting on a nucleic acid", "d": ["Catalytic activity that acts to modify a nucleic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53886", "l": "alpha,alpha-trehalose 6-phosphate + CDP + H(+) => CDP-alpha-D-glucose + D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57384", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA = (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.285", "l": "\"(13S,14R)-1,13-dihydroxy-N-methylcanadine 13-O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033798", "l": "thyroxine 5-deiodinase activity", "d": ["Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29531", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.259", "l": "\"dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33457", "l": "CO2 + NADPH + zymosterone => 4alpha-carboxyzymosterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10846", "l": "L-aspartate + pyridoxal => oxaloacetate + pyridoxamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800396", "l": "TP53 stimulates PIDD1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69483", "l": "an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine <=> beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12381", "l": "L-2,4-diaminobutanoate + pyruvate => L-alanine + L-aspartate 4-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77706", "l": "a ganglioside GA1 (d18:1(4E)) + GDP-beta-L-fucose <=> a ganglioside Fuc-GA1 (d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004065", "l": "arylsulfatase activity", "d": ["Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56966", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate => a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73833", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54842", "l": "H2O + NADP(+) + pentyl propanoate => H(+) + NADPH + O2 + octan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68450", "l": "(3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal => 13-cis-lycopene + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30585", "l": "2-demethylmenaquinone-8 + H2O + trimethylamine => 2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57767", "l": "2,6-dinitrotoluene + NADH + O2 <=> 3-methyl-4-nitrocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69535", "l": "(2S)-2-amino-4-deoxychorismate <=> 4-amino-4-deoxychorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69986", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791323", "l": "TP53 stimulates BCL2L14 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191072", "l": "Synthesis of Cx43 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76056", "l": "norreticuline + S-adenosyl-L-methionine => H(+) + reticuline + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50652", "l": "2-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73107", "l": "acacetin + S-adenosyl-L-methionine = apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16617", "l": "beta-D-glucosyl-(1->3)-D-glucose + phosphate = alpha-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.31", "l": "\"laminaribiose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71309", "l": "chloride(in) + L-valine(in) + 2 Na(+)(in) => chloride(out) + L-valine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61020", "l": "acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + 5-(carboxymethyl)uridine(34) in tRNA + CoA + 2 H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:2.3.1.311", "l": "\"tRNA carboxymethyluridine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679044", "l": "FKBP1A binds sirolimus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44113", "l": "hexadecanoyl-CoA + nonan-1-ol => CoA + nonyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047087", "l": "protopine 6-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + protopine = 6-hydroxyprotopine + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050287", "l": "sorbose 5-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: L-sorbose + NADP+ = 5-dehydro-D-fructose + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5621370", "l": "SYK autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983156", "l": "Polyubiquitination of substrate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18849", "l": "a 2'-unsubstituted isoflavone + O2 + reduced [NADPH--hemoprotein reductase] = a 2'-hydroxyisoflavone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043858", "l": "arginine:ornithine antiporter activity", "d": ["Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out)."], "t": []}, {"i": "RHEA:34991", "l": "L-arginine(out) + L-ornithine(in) = L-arginine(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75419", "l": "(R,S)-butane-2,3-diol + NAD(+) = (S)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674408", "l": "Regorafenib-resistant PDGFR mutants don't bind regorafenib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709547", "l": "ESTG binds ESR2:chaperone complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65341", "l": "acetyl-CoA + L-threonyl-[protein] => CoA + O-acetyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30981", "l": "AH2 + all-trans-3,4-didehydrolycopene => A + all-trans-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20935", "l": "L-erythrulose 1-phosphate <=> dihydroxyacetone phosphate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73448", "l": "acetyl-CoA(in) + AMP(out) => acetyl-CoA(out) + AMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201457", "l": "BMP2 binds to the receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975852", "l": "IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047567", "l": "3-methyleneoxindole reductase activity", "d": ["Catalysis of the reaction: 3-methyloxindole + NADP+ = 3-methyleneoxindole + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9658253", "l": "RAS:GTP binds PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031851", "l": "kappa-type opioid receptor binding", "d": ["Binding to a kappa-type opioid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433711", "l": "Cis-homodimerization of nectins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783681", "l": "LIF binds LIFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810076", "l": "DDO oxidizes D-Asp to OA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434836", "l": "Syk/Lck phosphorylate LAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23013", "l": "a fatty acid + S-adenosyl-L-methionine => a fatty acid methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655142", "l": "RCHY1 binds POLH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019767", "l": "IgE receptor activity", "d": ["Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2172678", "l": "PHF8 demethylates histone H4K20me1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19579", "l": "H(+) + luteolin 7-O-beta-D-glucoside + UDP => luteolin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25763", "l": "(2R,3S)-3-methylmalate + NAD(+) = 3-carboxy-2-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55938", "l": "all-trans-4-hydroxyretinal + H(+) + NADH => all-trans-4-hydroxyretinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034000", "l": "chondroitin-sulfate-ABC endolyase activity", "d": ["Catalysis of the endolytic cleavage of beta-1,4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75815", "l": "ATP + H2O + K(+)(in) = ADP + H(+) + K(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042934", "l": "achromobactin transmembrane transporter activity", "d": ["Enables the transfer of achromobactin, a citrate siderophore, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29330", "l": "(S)-malate(in) + succinate(out) <=> (S)-malate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729318", "l": "CSNK1A1 phosphorylates nucleoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789615", "l": "Expression of STAT3-upregulated extracellular proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42587", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O <=> 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23576", "l": "(R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] = berbamunine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.66", "l": "\"berbamunine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76416", "l": "Benzene is hydroxylated to phenol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0005287", "l": "high-affinity basic amino acid transmembrane transporter activity", "d": ["Enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44384", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26118", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + epi-cedrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35483", "l": "5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21403", "l": "2-oxoglutarate + CoA + NADP(+) <=> CO2 + NADPH + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14074", "l": "3-hydroxy-L-glutamate + H(+) => 4-amino-3-hydroxybutanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12939", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA => a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47470", "l": "(3E,5Z)-tetradecadienoyl-CoA => (2E,4E)-tetradecadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848314", "l": "IL36:IL1RL2 binds IL1RAP-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986258", "l": "SLIT2:ROBO1 binds CXCR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52181", "l": "(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] => (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23673", "l": "a quinone + L-quinate => 3-dehydroquinate + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9017491", "l": "RHOJ GEFs activate RHOJ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9754974", "l": "ADK phosphorylates RBV (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36017", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112604", "l": "Phosphorylated STATs are released (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16333", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] = diphosphate + holo-[citrate lyase ACP]", "d": [], "t": []}, {"i": "EC:2.7.7.61", "l": "\"citrate lyase holo-[acyl-carrier protein] synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47946", "l": "(2E)-geranyl phosphate + H(+) + phosphate => (2E)-geranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76286", "l": "guanine(out) + Na(+)(out) <=> guanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47255", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56900", "l": "a globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine = a globoside GlcNAc-(beta1->6)-GalGb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.181", "l": "\"13-deoxydaunorubicin hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033848", "l": "N2-(2-carboxyethyl)arginine synthase activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102506", "l": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose = cyanin betaine + ferulate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676229", "l": "WIPIs bind PI3P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981355", "l": "RASA1 binds RAS:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010309", "l": "acireductone dioxygenase [iron(II)-requiring] activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-methylthio-2-oxobutanoate + formate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48937", "l": "2-oxoglutarate + L-prolyl-[Skp1 protein] + O2 => CO2 + succinate + trans-4-hydroxy-L-prolyl-[Skp1 protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50457", "l": "prostaglandin H3 => prostaglandin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68831", "l": "borneol + NAD(+) <=> camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52638", "l": "a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate => 2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162188", "l": "COQ5 methylates MDMQ10H2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446207", "l": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73806", "l": "AIR + CO2 => CAIR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74988", "l": "erythrostominone(in) => erythrostominone(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848606", "l": "PTK6 phosphorylates PXN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785722", "l": "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52680", "l": "acetyl-CoA + L-alpha-phenylglycine = CoA + H(+) + N-acetyl-L-alpha-phenylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60524", "l": "5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77560", "l": "a 1-acyl-sn-glycerol + an acyl-CoA => a 1,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66246", "l": "diphosphate + IC-asc-C9-AMP => ATP + H(+) + IC-asc-C9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45639", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005000", "l": "vasopressin receptor activity", "d": ["Combining with vasopressin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62103", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730967", "l": "STAT1 stimulates SMAD7 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373730", "l": "Neurofascin and NrCAM heterodimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59058", "l": "dimethyl disulfide + H(+) + NADH => 2 methanethiol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67745", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O => 1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368087", "l": "RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-434362", "l": "Recruitment Of Cytoplasmic Proteins To Vesicles (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68473", "l": "(2Z,6Z)-farnesyl diphosphate => (E)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022065", "l": "DSPGs are secreted (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42525", "l": "uridine(1911/1915/1917) in 23S rRNA => pseudouridine(1911/1915/1917) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.3.3", "l": "\"lysine 5,6-aminomutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59291", "l": "beta-D-glucosyl-(1<->1)-sphing-4-enine + H2O <=> D-glucose + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417843", "l": "P2Y13 binds ADP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58247", "l": "H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] <=> ADP-D-ribose + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69703", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O = beta-D-galactose + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030600", "l": "feruloyl esterase activity", "d": ["Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66077", "l": "2-oxopentanoate + L-kynurenine => H2O + kynurenate + L-2-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653886", "l": "B4GALT1 binds LALBA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050088", "l": "mannose-6-phosphate 6-reductase activity", "d": ["Catalysis of the reaction: D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + 3 H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.112", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201443", "l": "Type II receptor phosphorylates type I receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75762", "l": "(9Z,11E)-octadecadienoate + H2O <=> 10-hydroxy-(11E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70349", "l": "3-bromo-L-tyrosine + NADPH => bromide + L-tyrosine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17583", "l": "an L-alpha-amino acid + CO2 + NH4(+) => an N-carbamoyl-L-alpha-amino acid + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70822", "l": "L-homoarginine(in) + L-ornithine(out) <=> L-homoarginine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62391", "l": "[(1->2)-beta-D-glucosyl](n) + H2O <=> [(1->2)-beta-D-glucosyl](n-2) + sophorose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045485", "l": "omega-6 fatty acid desaturase activity", "d": ["Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70982", "l": "FH tetramer hydrates fumarate to L-malate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64492", "l": "3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] = dehydrocitreoisocoumarin + H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835358", "l": "p-TARBP2 binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686359", "l": "SFTPs translocate from extracellular region to clathrin-coated vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112430", "l": "Formation of P-TEFb complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444433", "l": "Cho transports from the extracellular space to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63390", "l": "2 AH2 + Fe(II)-heme a => 2 A + Fe(II)-heme o + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018567", "l": "styrene dioxygenase activity", "d": ["Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70161", "l": "folate(out) + H(+)(out) => folate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39753", "l": "11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55490", "l": "ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694632", "l": "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2169046", "l": "Degradation of TGF-beta receptor complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023159", "l": "Carboxypeptidase E hydrolyzes Insulin(57-89) to yield C-peptide (Insulin(57-87)) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870465", "l": "RGGT binds the RAB-binding subunit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58515", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54477", "l": "1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63138", "l": "cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-adenosylglutathione => adenosylcob(III)alamin + apo-[alkylcobalamin reductase] + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683774", "l": "p-T68-CHEK2 dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36674", "l": "(17Z)-hexacosenoyl-CoA + sphinganine <=> CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40347", "l": "3-oxotetradecanedioyl-CoA + CoA = acetyl-CoA + dodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20142", "l": "an S-alkyl-L-cysteine S-oxide => 2-aminoprop-2-enoate + an S-alkyl sulfenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2169046", "l": "Degradation of TGF-beta receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28345", "l": "dITP + H2O <=> dIMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63961", "l": "abscisate(out) + ATP + H2O => abscisate(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38709", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3095889", "l": "MMACHC dealkylates RCbl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928624", "l": "EPHBs bind EFNBs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130706", "l": "MHC class II antigen processing (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102093", "l": "acrylate:acyl-coA CoA transferase activity", "d": ["Catalysis of the reaction: acryloyl-CoA + H2O = acrylate + coenzyme A + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15934", "l": "(S)-propane-1,2-diol + NAD(+) => (S)-lactaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59741", "l": "L-cysteinyl-[protein] + octadecanoyl-CoA => CoA + S-octadecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.94", "l": "\"glycerol-3-phosphate dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58820", "l": "H(+) + malonate + Na(+)(in) = acetate + CO2 + Na(+)(out)", "d": [], "t": []}, {"i": "EC:7.2.4.4", "l": "\"biotin-dependent malonate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58669", "l": "3-deoxyfructose + NADP(+) => 3-deoxyglucosone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-168440", "l": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689000", "l": "AADAC deacetylates PHEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102887", "l": "beta-sesquiphellandrene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = beta-sesquiphellandrene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27816", "l": "acetate(out) + Na(+)(out) => acetate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047502", "l": "(+)-sabinol dehydrogenase activity", "d": ["Catalysis of the reaction: (+)-cis-sabinol + NAD+ = (1S,5S)-sabinone + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250357", "l": "SHC1 binds P-ERBB4 isoform dimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48397", "l": "(3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine => 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110360", "l": "Recruitment of POLB to the AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102899", "l": "dehydroabietadienol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + dehydroabietadienol + NADPH + O2 = dehydroabietadiene-diol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67703", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424476", "l": "Activation of RAC1 by VAV2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31702", "l": "4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] <=> 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9641111", "l": "Parkin transfers Ub to misfolded proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63499", "l": "4-nitrobenzaldehyde + H(+) + NADPH <=> 4-nitrobenzyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78520", "l": "H2O + N-acetyl-2,7-anhydro-alpha-neuraminate => N-acetyl-alpha-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070284", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity", "d": ["Catalysis of the reaction: 5-aminoimidazole ribonucleotide + S-adenosylmethionine = 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate + 5'deoxyadenosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848726", "l": "PTK6 phosphorylates BCAR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49742", "l": "CO2 + deoxyviolacein + 2 H2O + NADP(+) => 2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-933533", "l": "Dimerization of p-IRF7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50907", "l": "L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174070", "l": "Association of Cdh1 with the APC/C (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166038", "l": "GPI-bound CD14 binds LPS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11973", "l": "4 Fe(2+) + 6 H2O + O2 => 12 H(+) + 4 iron(III) oxide-hydroxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66960", "l": "alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose = beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.383", "l": "\"GDP-Man:alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und beta-1,4-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78133", "l": "a 1,3-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63899", "l": "aspulvinone E + hnu <=> isoaspulvinone E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53781", "l": "beta-muricholate + lithocholoyl-CoA => beta-muricholoyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033987", "l": "2-hydroxyisoflavanone dehydratase activity", "d": ["Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429955", "l": "CCR4-NOT complex deadenylates mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9736953", "l": "FURIN translocates to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69273", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate => allyl isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49234", "l": "D-mannose 6-phosphate(in) + L-histidyl-[protein] => D-mannose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.51128060092941", "identifiers": [{"i": "GO:0009055", "l": "electron transfer activity", "d": ["A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52100", "l": "5-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070040", "l": "rRNA (adenine(2503)-C2-)-methyltransferase activity", "d": ["Catalysis of the reaction: adenosine2503 in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine2503 in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982645", "l": "GRKs bind ADRB2:Catecholamine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389083", "l": "Autophosphorylation of PDGF alpha receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380177", "l": "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796043", "l": "NFE2L2 dependent BCL2L1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68562", "l": "1-arsono-3-phospho-D-glycerate + H(+) + NADH => arsenate + D-glyceraldehyde 3-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717525", "l": "RSV NS1 (1C) binds TRIM25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909729", "l": "Activation of JAK kinases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629237", "l": "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55229", "l": "4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190065", "l": "Activated TrkA receptor internalizes to endosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193703", "l": "IKKbeta is activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824582", "l": "MAPK1 phosphorylates SOX10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10112", "l": "L-homocysteine + L-serine = H2O + L,L-cystathionine", "d": [], "t": []}, {"i": "EC:4.2.1.22", "l": "\"cystathionine beta-synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52622", "l": "2,2-dimethylpropanoyl-CoA => 3-methylbutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57937", "l": "H2O + isopyridoxal + NAD(+) => 5-pyridoxate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29647", "l": "alpha-maltopentaose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotetraose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18424", "l": "acetyl-CoA + chloramphenicol <=> chloramphenicol 3-acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784676", "l": "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796368", "l": "RIPK1 binds STUB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23329", "l": "a 9-cis-epoxycarotenoid + O2 => 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018629", "l": "2-hydroxyquinoline 5,6-dioxygenase activity", "d": ["Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180032", "l": "histone H4K5 deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 12) + H2O = histone H4 L-lysine (position 5) + acetate. This reaction represents the removal of an acetyl group from lysine at position 5 of the histone H4 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218806", "l": "FYN autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65979", "l": "7-dehydrocholesterol + hnu <=> previtamin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34181", "l": "D-glucuronate + H(+) + mycophenolate => H2O + mycophenolic acid O-acyl-beta-D-glucuronide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70142", "l": "6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16205", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] = N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450971", "l": "NNT dimer transfers proton from NADPH to NAD+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564112", "l": "Collagen type VI degradation by MMP2,9,11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9842833", "l": "SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67805", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(20)-[histone H4] + O2 => CO2 + formaldehyde + L-lysyl(20)-[histone H4] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675417", "l": "PEBP1 binds activated RAF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800035", "l": "IGFBP3 binds TMEM219 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52046", "l": "H(+) + mogroside IE + UDP => mogrol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60337", "l": "N(6)-methyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54833", "l": "a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase] => a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71744", "l": "2-oxoglutarate(out) + hexanedioate(in) => 2-oxoglutarate(in) + hexanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71489", "l": "L-phenylalanyl-L-leucine + L-tyrosylglycylglycine => H2O + Leu-enkephalin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619449", "l": "PPM1F dephosphorylates p-T286-CaMKII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9695949", "l": "SPHK2 phosphorylates sphingoid (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69685", "l": "beta-D-glucose + daidzein + H(+) => daidzein 7-O-beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047847", "l": "deoxyuridine phosphorylase activity", "d": ["Catalysis of the reaction: 2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13057", "l": "an N-acylneuraminate 9-phosphate + H2O = an N-acylneuraminate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.29", "l": "\"N-acylneuraminate-9-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45276", "l": "12-phosphooxy-(9E)-octadecenoate + H2O = 12-hydroxy-(9E)-octadecenoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10525", "l": "2-oxoglutarate + H(+) => CO2 + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67001", "l": "2-methylpropanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + phlorisobutanophenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66905", "l": "A + cannabinerolate => AH2 + cannabichromenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5618107", "l": "ATP binding to HSP90 triggers conformation change (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622386", "l": "LEF1 binds the promoter of the CEBPA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102870", "l": "7-hydroxyflavone-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 7-hydroxyflavone = 7-O-beta-D-glucosyl-7-hydroxyflavone + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033898", "l": "Bacillus subtilis ribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage to 2',3'-cyclic nucleotides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201608", "l": "Caspase-mediated cleavage of alpha adducin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532667", "l": "Removal of the second glucose by glucosidase II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54862", "l": "(1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+) => (2E)-geranial + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59329", "l": "D-xylono-1,5-lactone + H2O => D-xylonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977371", "l": "Factor I inactivates Factor H-boundC3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804229", "l": "JMY, TTC5 and EP300 bind (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392513", "l": "Rap1 signal termination by Rap1GAPs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47756", "l": "guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0042924", "l": "neuromedin U binding", "d": ["Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43559", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70401", "l": "CoA + H(+) + N-tetracosanoyl-3-oxosphinganine => 3-oxosphinganine + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023941", "l": "MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13487", "l": "3-((4-bromophenyl)sulfanyl)-2-oxopropanoate + L-glutamate => 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709883", "l": "BIL:ALB scavenges O2.- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74031", "l": "cGMP binds CNG channel to form cGMP:CNG channel (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878056", "l": "RUNX1:CBFB binds EP300 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41412", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44082", "l": "AMP + diphosphate + undecanoyl-CoA => ATP + CoA + undecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203979", "l": "Coat Assembly (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199112", "l": "CRTAM binds to NECL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167118", "l": "NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2247511", "l": "STAB2:ligand is endocytosed (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21771", "l": "H2O + N-methyl-L-alanine + NADP(+) <=> H(+) + methylamine + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40234", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66937", "l": "(E)-caffeoyl-CoA + 5-hydroxyanthranilate => avenanthramide C + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77624", "l": "(2E)-decenoyl-CoA + H(+) + oxaloacetate => (4-octa-1-enyl-2,5-dioxo-2,5-dihydro-3-furanyl)acetate + CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112125", "l": "Oxidative dealkylation of 1-EtA damaged DNA by ABH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52138", "l": "a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+) => a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59402", "l": "D-2-aminohexanoate => L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759209", "l": "LRP2 binds extracellular TCN2:RCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660666", "l": "CBP and p300 binds NF-kB complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950782", "l": "p-STAT1 binds p-STAT3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807585", "l": "BPI binds LPS on the bacterial surface (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102310", "l": "dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose-forming) activity", "d": ["Catalysis of the reaction: dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose + NAD(P) = dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate + 2 H+ + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50536", "l": "prostaglandin E2 = H2O + prostaglandin A2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201608", "l": "Caspase-mediated cleavage of alpha adducin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373705", "l": "Caspase cleavage of DCC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40395", "l": "1,2-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-500708", "l": "GRIK3 homomer binds glutamate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624129", "l": "LZTFL1 binds the BBSome and prevents its traffic to the cilium (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66958", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => alpha-L-rhamnosyl-(1->3)-alpha-D-galactosyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664346", "l": "IL10 gene produces IL10 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678822", "l": "Defective CFTR does not transport Cl- from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53304", "l": "AH2 + 2 ATP + 2 cob(II)alamin = A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686345", "l": "SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13799", "l": "di-trans,poly-cis-dolichol + phosphate => a dolichyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607740", "l": "PKC-delta phosphorylates CARD9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52529", "l": "2-oxoglutarate + L-asparagine => 2-oxosuccinamate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41056", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209891", "l": "Dopamine is oxidised to noradrenaline (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195275", "l": "Phosphorylation of APC component of the destruction complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50945", "l": "3-phenylpropanoate + NAD(+) => (E)-cinnamate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22218", "l": "3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+) => (E)-caffeate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1297444", "l": "Binding of cAMP to HCN channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51655", "l": "D-mannonate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20401", "l": "a beta-lactam + H2O = a substituted beta-amino acid", "d": [], "t": []}, {"i": "EC:3.5.2.6", "l": "\"beta-lactamase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24507", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 <=> 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28349", "l": "7,8-dihydroneopterin 3'-triphosphate <=> 7,8-dihydromonapterin 3'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21731", "l": "GDP-alpha-D-mannose + H2O + 2 NAD(+) <=> GDP-alpha-D-mannuronate + 3 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215406", "l": "PRMT5 binds WDR77 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015621", "l": "ferric triacetylfusarinine C transmembrane transporter activity", "d": ["Enables the transfer of ferric triacetylfusarinine C from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847880", "l": "CYTH proteins bind ARF1:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404135", "l": "RBP4 binds atROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44124", "l": "hexadecanoyl-CoA + tetradecan-1-ol = CoA + tetradecanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43488", "l": "7(1)-hydroxychlorophyll a + NAD(+) = chlorophyll b + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667965", "l": "ANKLE2 binds PP2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.4.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24463", "l": "H(+) + malonyl-[ACP] <=> acetyl-[ACP] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32783", "l": "ATP + glycine betaine(out) + H2O = ADP + glycine betaine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803890", "l": "SFN dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047976", "l": "hamamelose kinase activity", "d": ["Catalysis of the reaction: D-hamamelose + ATP = D-hamamelose 2'-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69524", "l": "D-sorbitol + O2 = D-glucose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.698016197404442", "identifiers": [{"i": "GO:0016860", "l": "intramolecular oxidoreductase activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48331", "l": "a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a III(4)-a-Fuc-Lc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20198", "l": "[heparosan-N-sulfate](n) => [heparan-N-sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5681987", "l": "LC3 is cleaved by ATG4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64711", "l": "butan-1-ol + NADP(+) <=> butanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75499", "l": "cholate(out) + n H(+)(out) = cholate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928657", "l": "MMP2,9 cleave EPHB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36357", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine => 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047833", "l": "D-sorbitol dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67546", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z-tetradecenoyl)-4'-phosphopantetheine => (9Z)-tetradecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5631941", "l": "SESN1,2,3 bind AMPK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13455", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3-sulfate => 3'-phosphoadenylyl sulfate + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928645", "l": "EPHB:NMDAR binds TIAM1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10683", "l": "L-proline <=> D-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755328", "l": "SARS-CoV-2 8 binds class I MHC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50724", "l": "(E)-4-hydroxyphenylacetaldehyde oxime = (Z)-(4-hydroxyphenyl)acetaldehyde oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110219", "l": "Cleavage of thymine by TDG glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58238", "l": "H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] => L-tyrosyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73755", "l": "2 H(+)(out) + histamine(in) = 2 H(+)(in) + histamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56737", "l": "H2O + O2 + retinal => H(+) + H2O2 + retinoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199587", "l": "KIR2DS1 interacting with HLA-C group 2 (Cw4) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53887", "l": "CDP-alpha-D-glucose + D-glucose 6-phosphate <=> alpha,alpha-trehalose 6-phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42164", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2 = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66601", "l": "2 dopamine + O2 => 2 dopamine quinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18863", "l": "a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine => a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62885", "l": "O2 + 4 semiviriditoxin => 2 (M)-viriditoxin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46002", "l": "1-tuberculosinyladenosine + diphosphate => adenosine + H(+) + tuberculosinyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74712", "l": "Dissociation of IRS-P from insulin receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23408", "l": "NADP(+) + precorrin-6B = 2 H(+) + NADPH + precorrin-6A", "d": [], "t": []}, {"i": "EC:1.3.1.54", "l": "\"precorrin-6A reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63237", "l": "ATP + streptomycin => 6-O-adenylylstreptomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.616479785166973", "identifiers": [{"i": "GO:0000175", "l": "3'-5'-RNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733330", "l": "CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432909", "l": "Interaction of Plectin with Integrin beta 4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45797", "l": "(3R)-3-hydroxybutanoyl-CoA + NADP(+) => acetoacetyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654603", "l": "Activated FGFR2 binds FRS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855375", "l": "PTPN22 dissociates from CSK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9675026", "l": "Formation of the MLL1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420883", "l": "Opsins act as GEFs for G alpha-t (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653974", "l": "Ragulator binds Rag dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112392", "l": "Resumption of elongation after recovery from pausing (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419269", "l": "TSFM binds TUFM displacing GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32388", "l": "dihydrocarveol + NAD(+) => dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41886", "l": "3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP] => dodecanoyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158959", "l": "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60023", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquisabinene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18821", "l": "acetyl-CoA + choline = acetylcholine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.6", "l": "\"choline O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67268", "l": "(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate = sch 210972", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654565", "l": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0071813", "l": "lipoprotein particle binding", "d": ["Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954182", "l": "ERBB4s80:TAB2:NCOR1 complex binds S100B gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44705", "l": "a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59800", "l": "decanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-decanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36056", "l": "a 2-amino-4-hydroxypteridine + H(+) + H2O => a 2,4-dihydroxypteridine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74685", "l": "4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether + 4 H(+) + 4 L-methionine => 2 AH2 + 2 archaeol + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14274", "l": "A + H2O + spermidine => 4-aminobutanal + AH2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15618", "l": "Fe(3+) + Fe(II)-[cytochrome c] => Fe(2+) + Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046101", "l": "Peroxisomal beta-oxidation of tetracosapentaenoyl-CoA to Docosapentaenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67270", "l": "sch 210972 => (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031761", "l": "fMet-Leu-Phe receptor binding", "d": ["Binding to a fMet-Leu-Phe receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160884", "l": "HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11542", "l": "an N-acyl-D-mannosaminolactone + H(+) + NADH => an N-acyl-D-mannosamine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875817", "l": "MET phosphorylates STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694280", "l": "mRNA4 is translated to protein E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77089", "l": "N-pyruvoyl-L-glutamate + salicylate => isochorismoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41358", "l": "geranylgeranyl-bacteriochlorophyllide a + 3 H(+) + 3 NADPH => bacteriochlorophyll a + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170799", "l": "cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22776", "l": "2 H(+) + H2O2 + 2 Mn(2+) = 2 H2O + 2 Mn(3+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12571", "l": "4-nitrophenol + H(+) + NADH + O2 <=> 4-nitrocatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37161", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35241", "l": "tetracycline(out) => tetracycline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047697", "l": "beta-alanopine dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-beta-alanopine + H2O + NAD+ = beta-alanine + H+ + NADH + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9825788", "l": "p-S207 KARS displaces HINT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64175", "l": "L-altrarate <=> galactarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38150", "l": "carbon disulfide + H2O <=> carbonyl sulfide + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64156", "l": "an N-(fatty acyl)-L-methionine + H2O = a fatty acid + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12688", "l": "2 mycothiol + NADP(+) <=> H(+) + mycothione + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22013", "l": "precorrin-4 + S-adenosyl-L-methionine => precorrin-5 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55242", "l": "(9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+) => 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428917", "l": "G13 activation by TP receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31362", "l": "FMNH2 + nitrilotriacetate + O2 <=> aminodiacetate + FMN + glyoxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706330", "l": "Active FLT3 binds to SOCS6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696605", "l": "USP12, USP26 deubiquitinate AR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70576", "l": "3',5'-cyclic UMP + H2O => H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247843", "l": "secretion of WNT ligands (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77222", "l": "a dolichyl beta-D-mannosyl phosphate + L-tryptophyl-[protein] <=> a dolichyl phosphate + C-alpha-D-mannosyl-L-tryptophyl-[protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0047850", "l": "diaminopimelate dehydrogenase activity", "d": ["Catalysis of the reaction: meso-2,6-diaminopimelate + H2O + NADP+ = L-2-amino-6-oxopimelate + H+ + NADPH + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714691", "l": "RAC3 binds ER effectors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26085", "l": "(4S)-limonene + H(+) + NADPH + O2 = H2O + limonene 1,2-epoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031434", "l": "mitogen-activated protein kinase kinase binding", "d": ["Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30571", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine = 6 AMP + 6 diphosphate + enterobactin + 4 H(+)", "d": [], "t": []}, {"i": "EC:6.3.2.14", "l": "\"enterobactin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685604", "l": "SLAMF6 binds SLAMF6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68260", "l": "D-serine(in) + Na(+)(in) = D-serine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69972", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74996", "l": "epierythrostominol(in) => epierythrostominol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35676", "l": "H(+) + L-serine + tetradecanoyl-CoA => 3-oxohexadecasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34880", "l": "2 H2O + methyl 3-cyano-2-phenylpropanoate => 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210290", "l": "Interaction of PECAM-1 and SHIP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021068", "l": "PalmS-ESRs bind CAVs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201691", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74596", "l": "(2S,3R)-3-methyl-L-aspartate => mesaconate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63383", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38551", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2 = (R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015193", "l": "L-proline transmembrane transporter activity", "d": ["Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid."], "t": []}, {"i": "REACT:R-HSA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.85", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36423", "l": "2-[(3S)-3-carboxy-3-(methylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22182", "l": "(S)-norcodamine + H(+) + S-adenosyl-L-homocysteine => (S)-norreticuline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38155", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (6E,10E)-geranyllinalool + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.144", "l": "\"geranyllinalool synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32699", "l": "(2E,6E)-farnesyl diphosphate = beta-sesquiphellandrene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.123", "l": "\"beta-sesquiphellandrene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50912", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol = 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.46", "l": "\"teichoic acid ribitol-phosphate primase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592246", "l": "Expression of TFAM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733705", "l": "Expression of GATA4 in cardiogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2029473", "l": "Branching and elongation of mother and daughter filaments (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21614", "l": "2-dehydro-3-deoxy-D-gluconate + H2O => D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34426", "l": "(-)-secoisolariciresinol + NADP(+) <=> (+)-lariciresinol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8943003", "l": "SHPRH polyubiquitinates monoubiquitinated PCNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44403", "l": "3-demethylubiquinol-6 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0030284", "l": "nuclear estrogen receptor activity", "d": ["Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78572", "l": "docosanoyl-CoA + O2 => (2E)-docosenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18508", "l": "L-lysine + NAD(+) <=> Delta(1)-piperideine-2-carboxylate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19865", "l": "4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III", "d": [], "t": []}, {"i": "EC:4.1.1.37", "l": "\"uroporphyrinogen decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48485", "l": "a propanoate ester + H2O => an aliphatic alcohol + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0160009", "l": "histone decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] = (2E)-2-butenoate + L-lysyl-[histone]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5633051", "l": "EFCAB7:IQCE binds EVC2:EVC (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9732527", "l": "FFAR1 binds rosiglitazone (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44952", "l": "(2E)-octenoyl-CoA + H(+) + NADPH = NADP(+) + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57448", "l": "ATP + D-tyrosine + tRNA(Tyr) = AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16938", "l": "1-O-alkyl-sn-glycerol + ATP => 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74638", "l": "2-oxoglutarate + 5-dehydro-6-demethoxyfumagillol + O2 <=> 5-dehydro-6-demethoxy-6-hydroxyfumagillol + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50596", "l": "acetyl-CoA + N-terminal L-seryl-[histone H4] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9032798", "l": "DOCK3 activates RAC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55479", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54665", "l": "(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene => pre-alpha-onocerin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.212", "l": "\"hyaluronan synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18316", "l": "(R)-mandelonitrile <=> benzaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38873", "l": "pseudouridine(2457) in 23S rRNA => uridine(2457) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14319", "l": "H(+) + morphinone + NADH => morphine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23045", "l": "H(+) + N,N-dihydroxy-L-tyrosine => (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11166", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40776", "l": "2-amino-2-phenylacetonitrile + H(+) + 2 H2O => D-alpha-phenylglycine + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25488", "l": "(2E)-geranyl diphosphate = (1S,5S)-alpha-pinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.119", "l": "\"(-)-alpha-pinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56116", "l": "2-all-trans-decaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-decaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32286", "l": "3-hydroxyanthranilate + O2 <=> H(+) + H2O + quinolinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75787", "l": "GTP(in) = GTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59829", "l": "H2O + S-inosyl-L-homocysteine => inosine + L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975633", "l": "atROL binds to RBP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114256", "l": "CYCS:APAF1 binds procaspase-9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36204", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78532", "l": "beta-D-glucosylceramide + H2O => a  beta-D-glucosyll-(1<->1')-sphingoid base + a fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10249", "l": "dUTP + H2O => diphosphate + dUMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22847", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] <=> glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432054", "l": "Aquaporin-1 passively transports water out of cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54583", "l": "a 5'-end dephospho-ribonucleoside-RNA + ATP <=> a 5'-end 5'-phospho-ribonucleoside-RNA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010231", "l": "ROBO1 binds FLRT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21932", "l": "S-adenosyl-L-methionine = L-homoserine lactone + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:4.4.1.42", "l": "\"S-adenosyl-L-methionine lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102695", "l": "UDP-glucose:cis-zeatin 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin = H+ + cis-zeatin-7-N-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51382", "l": "CoA + H(+) + N-(9Z-octadecanoyl)-dopamine => (9Z)-octadecenoyl-CoA + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20877", "l": "(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58852", "l": "(6E)-8-oxogeraniol + NAD(+) = (6E)-8-oxogeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482770", "l": "Release of platelet secretory granule components (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870461", "l": "RABGGTA and RABGGTB bind (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68244", "l": "L-phenylalanine(in) + Na(+)(in) = L-phenylalanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18879", "l": "1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982617", "l": "CYGB:O2 dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696822", "l": "AKR1B15 reduces EST17b to E1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177923", "l": "Sustained activation of SRC kinase by SHP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73170", "l": "CoA(out) + NAD(+)(in) <=> CoA(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46163", "l": "a quinone + H(+) + NADH <=> a quinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097003", "l": "adipokinetic hormone receptor activity", "d": ["Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are protein or peptide hormones that are important for sugar and fat homeostasis in metazoa. In insects, they mobilize sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61733", "l": "steviol + UDP-alpha-D-glucose => H(+) + steviolmonoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13999", "l": "2-methylpropanoyl-CoA + CO2 + NADH => 3-methyl-2-oxobutanoate + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847534", "l": "RAB43 hydrolyses GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754974", "l": "ADK phosphorylates RBV (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008316", "l": "structural constituent of vitelline membrane", "d": ["The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28473", "l": "pyridoxine(in) <=> pyridoxine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030351", "l": "inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate."], "t": []}, {"i": "REACT:R-HSA-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004991", "l": "parathyroid hormone receptor activity", "d": ["Combining with parathyroid hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78370", "l": "H2O + N(tau)-methylhistamine + O2 <=> 1-methylimidazole-4-acetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75836", "l": "(5S)-hydroperoxy-(6E,8Z)-octadecadienoate + 2 glutathione => (5S)-hydroxy-(6E,8Z)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54906", "l": "(9Z)-hexadecenoyl-[ACP] + NAD(+) => (2E,9Z)-hexadecadienoyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66758", "l": "ADP + domoate(out) + H(+) + phosphate => ATP + domoate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15964", "l": "4-hydroxymandelonitrile + UDP-alpha-D-glucose <=> H(+) + taxiphyllin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805981", "l": "HMGB1 release from cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40870", "l": "(9E)-octadecenoyl-CoA + FAD + H(+) <=> (2E,9E)-octadecadienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031748", "l": "D1 dopamine receptor binding", "d": ["Binding to a D1 dopamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59959", "l": "a (Z)-N-(sulfonatooxy)alkanimidothioate <=> a nitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.47", "l": "\"D-ribulokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938773", "l": "RNF144A polyubiquitinates PRKDC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620004", "l": "RSKs autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39506", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH <=> (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047412", "l": "N-(long-chain-acyl)ethanolamine deacylase activity", "d": ["Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842671", "l": "Active LTK binds IRS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78565", "l": "3-oxotetracosanoyl-CoA + H(+) + NADH => (3R)-hydroxytetracosanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683774", "l": "p-T68-CHEK2 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78355", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73922", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+) <=> H2O + norlichexanthone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31654", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682026", "l": "MRN bound to shortened telomeres activates ATM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24786", "l": "3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 => 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9028730", "l": "Activated NTRK2 binds FRS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209231", "l": "DOME:HOP complex forms a dimer at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35943", "l": "brevianamide F + dimethylallyl diphosphate = deoxybrevianamide E + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.109", "l": "\"brevianamide F prenyltransferase (deoxybrevianamide E-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72584", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) => 3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40314", "l": "hexanoyl-CoA + O2 <=> (2E)-hexenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67488", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49792", "l": "eicosanoyl-CoA + glycine = CoA + H(+) + N-eicosanoylglycinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418865", "l": "Recruitment of ABLIM to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110210", "l": "TDG glycosylase mediated recognition and binding of an ethenocytosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75431", "l": "32-hydroxyeburicol + O2 + reduced [NADPH--hemoprotein reductase] = 32-oxoeburicol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4341072", "l": "SUMOylation of RARA with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38460", "l": "2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + a mycolipenoyl-CoA => 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8953946", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13825", "l": "GDP-alpha-D-rhamnose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18491", "l": "carbamate + CO2 => cyanate + H(+) + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956676", "l": "YAP1 binds TP73 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015633", "l": "ABC-type zinc transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28866", "l": "H(+)(out) + lactose(in) <=> H(+)(in) + lactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65499", "l": "3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH <=> 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21578", "l": "2-methylcholine + CO2 => carnitine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624494", "l": "RAF1 binds p21 RAS:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27304", "l": "3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => 7-chloro-L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49251", "l": "galactitol(out) + N(pros)-phospho-L-histidyl-[protein] <=> galactitol 1-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21469", "l": "dTDP-alpha-D-mycaminose + tylactone => 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74453", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428664", "l": "SGPP1,2 dephosphorylate sphingoid-1-phosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34349", "l": "(2E)-geranial + H(+) + NADH => (2E)-geraniol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70531", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60480", "l": "2 UTP = c-di-UMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50491", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18144", "l": "NAD(+) + trans-cyclohexane-1,2-diol <=> 2-hydroxycyclohexan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76195", "l": "UDP-alpha-D-glucose(in) = UDP-alpha-D-glucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29362", "l": "H2O + UMP <=> phosphate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977363", "l": "Factor H binds to C3bBb (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36493", "l": "(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10522", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62422", "l": "a fatty acid + CO2 + H2O => a (R)-2-hydroxy fatty acid + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.11", "l": "\"cAMP-dependent protein kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56915", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) <=> (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10672", "l": "cyclobutadithymidine in DNA = a thymidine dimer in DNA", "d": [], "t": []}, {"i": "EC:4.1.99.3", "l": "\"deoxyribodipyrimidine photo-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49071", "l": "25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043758", "l": "acetate-CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14417", "l": "acetyl phosphate + L-lysine = H(+) + N(6)-acetyl-L-lysine + phosphate", "d": [], "t": []}, {"i": "EC:2.3.1.32", "l": "\"lysine N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956458", "l": "RNLS:FAD oxidises dh-beta-NAD to NAD+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5671993", "l": "CIT-3 binds DLG4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046180", "l": "KSPG is secreted from the cell (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102764", "l": "6-deoxotyphasterol C-23 hydroxylase activity", "d": ["Catalysis of the reaction: 6-deoxotyphasterol + O2 + a reduced electron acceptor = 6-deoxocastasterone + H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2219524", "l": "PDPK1 binds PIP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65347", "l": "H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA <=> (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68954", "l": "Mcm2-7 is phosphorylated by DDK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61736", "l": "steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25790", "l": "pyruvate + succinate semialdehyde => 4-hydroxy-2-oxoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78545", "l": "L-alanine + S-sulfanyl-L-cysteine => 2 L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.185573331668621", "identifiers": [{"i": "GO:1990837", "l": "sequence-specific double-stranded DNA binding", "d": ["Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38449", "l": "4-O-(beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose => 4-O-(beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranosyl)-(2S,4S)-4-hydroxyproline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1449687", "l": "Corticosteroids bind to CBG in blood (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52667", "l": "a short-chain (3S)-3-hydroxyacyl-CoA <=> a short-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68954", "l": "H(+) + S-adenosyl-L-homocysteine + scoparone => isoscopoletin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781922", "l": "USP13 binds UFD1L:SKP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162188", "l": "COQ5 methylates MDMQ10H2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10567", "l": "H2O + oxaloacetate 4-methyl ester <=> H(+) + methanol + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31582", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate <=> (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679028", "l": "JAK3 binds JAK3 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33295", "l": "L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18358", "l": "NADP(+) + tropine => H(+) + NADPH + tropinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68452", "l": "all-trans-10'-apo-beta-carotenal + O2 = 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28108", "l": "H(+) + keto-D-tagatose 6-phosphate + NADH => galactitol 1-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42441", "l": "L-aspartate + NAD(+) => H(+) + iminosuccinate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140343", "l": "phosphatidylserine transfer activity", "d": ["Removes phosphatidylserine from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37703", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15607", "l": "H(+) + NH4(+) + pyruvate + sulfate => H2O + L-serine O-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23720", "l": "ATP + hydrogencarbonate + propanoyl-CoA = (S)-methylmalonyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.4.1.3", "l": "\"propionyl-CoA carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018787", "l": "4-chlorobenzoyl-CoA dehalogenase activity", "d": ["Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106274", "l": "NAD+-protein-arginine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.41", "l": "\"(E)-2-methylbutanal oxime monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45955", "l": "L-asparaginyl-[protein] + UDP-alpha-D-glucose <=> H(+) + N(4)-(beta-D-glucosyl)-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41261", "l": "(E)-3-(indol-3-yl)acrylate + NH4(+) => L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71164", "l": "HGD dioxygenates homogentisate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15676", "l": "acetoacetyl-CoA + H2O <=> acetoacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74767", "l": "S-adenosyl-L-methionine + syringetin = 3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62856", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31239", "l": "4 H(+) + uroporphyrinogen I = 4 CO2 + coproporphyrinogen I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78528", "l": "adenosine(N)/adenosine(N+1) in rRNA + 4 S-adenosyl-L-methionine => 4 H(+) + N(6)-dimethyladenosine(N)/N(6)-dimethyladenosine(N+1) in rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63764", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34004", "l": "5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH + O2 => 7-dehydrodesmosterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1253282", "l": "ERBB4 ubiquitination by WWP1/ITCH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76868", "l": "(R)-1-phenylethylamine + H2O + NAD(+) => acetophenone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73780", "l": "dimethylallyl diphosphate + preechinulin => diphosphate + tardioxopiperazine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65980", "l": "hnu + previtamin D3 = tachysterol 3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58379", "l": "decan-1-ol + NADP(+) <=> decanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987043", "l": "IL22RA1 binds JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015068", "l": "glycine amidinotransferase activity", "d": ["Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18943", "l": "a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH => a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416683", "l": "SEMA3E binds to PLXND1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176116", "l": "Recruitment and activation of Chk1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20493", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.244", "l": "\"N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389862", "l": "Conversion of glyoxylate to oxalate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35131", "l": "H(+)(out) + L-alanyl-L-glutamate(out) = H(+)(in) + L-alanyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57295", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O <=> a guanosine in RNA + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851104", "l": "NPM1-ALK- and STAT3-dependent ICOS gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044715", "l": "8-oxo-dGDP phosphatase activity", "d": ["Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3828025", "l": "DCN (decorin) degradation by MMP14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174446", "l": "Removal of remaining Flap from the C-strand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549192", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050532", "l": "2-phosphosulfolactate phosphatase activity", "d": ["Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H2O = (R)-3-sulfolactate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52137", "l": "a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O => a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31863", "l": "(S)-2,3-epoxysqualene = friedelin", "d": [], "t": []}, {"i": "EC:5.4.99.50", "l": "\"friedelin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20466", "l": "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67383", "l": "H2O + L-alanyl-L-cysteine <=> L-alanine + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72525", "l": "1-hydroxy-6-methoxyphenazine + H(+) + S-adenosyl-L-homocysteine => 1,6-dihydroxyphenazine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76018", "l": "(3R)-hydroxybutanoate trimer + H2O <=> (3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755304", "l": "MUL1 ubiquitinates UBXN7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769397", "l": "SOST binds LRP5/6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40735", "l": "(20S)-ginsenoside Rb1 + 2 H2O = 2 D-glucose + gypenoside LXXV", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78954", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O <=> a 1,2-diacyl-sn-glycerol + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9671145", "l": "DKC1 binds SHQ1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67687", "l": "a long-chain fatty acid(in) + ATP + H2O <=> a long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210277", "l": "Interaction of PECAM-1 and SHP-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37282", "l": "ATP + H2O + L-alanyl-L-histidine(out) <=> ADP + H(+) + L-alanyl-L-histidine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15692", "l": "H(+) + L-2,4-diaminobutanoate <=> CO2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793375", "l": "Expression of MSGN1 in paraxial mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64243", "l": "glycine + octanoyl-CoA <=> CoA + H(+) + N-octanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11115", "l": "H2O + isochorismate <=> (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63620", "l": "ATP + dodecanoate + holo-[ACP] = AMP + diphosphate + dodecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35028", "l": "ATP + H2O + tungstate(in) => ADP + H(+) + phosphate + tungstate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21622", "l": "FMN + 2 H(+) + NADH => FMNH2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37251", "l": "cysteamine S-phosphate + H2O = cysteamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011985", "l": "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24486", "l": "H(+) + NADH + sulcatone => NAD(+) + sulcatol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016213", "l": "linoleoyl-CoA desaturase activity", "d": ["Catalysis of the reaction: (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-CoA and add a fourth double bond (a (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9716947", "l": "ESR1 binds ESR1 agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46316", "l": "GDP-N,N'-diacetylbacillosamine + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382053", "l": "Translocation of PDGF from ER to Golgi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0044549", "l": "GTP cyclohydrolase binding", "d": ["Binding to a GTP cyclohydrolase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47184", "l": "5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23031", "l": "malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] <=> acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13897", "l": "chorismate = prephenate", "d": [], "t": []}, {"i": "EC:5.4.99.5", "l": "\"chorismate mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008874", "l": "gluconate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70080", "l": "2-oxoglutarate + clavatol + O2 => CO2 + hydroxyclavatol + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64754", "l": "3-sulfanyl-1-pentanol + NH4(+) + pyruvate => 3-sulfanylpentan-1-ol-L-cysteine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47442", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(7Z-hexadecenoyl)-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36185", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+) => a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69237", "l": "(Z)-3-hydroxypropyl-N-(sulfonatooxy)methanimidothioate => 4-hydroxybutylnitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062045", "l": "L-lysine alpha-aminotransferase", "d": ["Catalysis of the reaction: L-lysine + pyruvate= epsilon-amino-alpha-ketocaproic acid (KAC) + alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70629", "l": "2''-O-dodecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-dodecanoyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664278", "l": "Phosphorylation and activation of PLCG due to FCGR3A effect (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40767", "l": "(20S)-ginsenoside R1 + H2O = (20S)-ginsenoside Rg1 + D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048472", "l": "threonine-phosphate decarboxylase activity", "d": ["Catalysis of the reaction: O-phospho-L-threonine + H+ = (R)-1-aminopropan-2-yl phosphate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950456", "l": "IL12B dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:1990459", "l": "transferrin receptor binding", "d": ["Binding to a transferrin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694421", "l": "PP6 dephosphorylates SEC24 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11667", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate <=> 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30572", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine => 6 AMP + 6 diphosphate + enterobactin + 4 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46289", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424486", "l": "Phosphorylation and activation of VAV2/VAV3 by SYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404193", "l": "IGF1R phosphorylates SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67928", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O = a 3'-end 3'-phosphouridine-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30583", "l": "2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide = 2-demethylmenaquinone-8 + H2O + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73620", "l": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0022840", "l": "leak channel activity", "d": ["Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592362", "l": "Activation of proMMP7 by MMP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28522", "l": "D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.83", "l": "\"D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32963", "l": "2-oxoglutaramate + H2O = 2-oxoglutarate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5490269", "l": "AFXBO-C, AFNBO-C translocate from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875374", "l": "MET binds LRIG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71619", "l": "(S)-malate(in) + 2 thiosulfate(out) = (S)-malate(out) + 2 thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68272", "l": "a fatty acyl-CoA + L-seryl-[protein] = CoA + O-fatty acyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28832", "l": "D-gluconate(in) + H(+)(in) => D-gluconate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692376", "l": "BCL2 binds BCL2 antagonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314678", "l": "ASA- acetylates PTGS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162195", "l": "COQ4 decarboxylates MHDB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23458", "l": "A + crepenynate + 2 H2O => (9Z,12Z)-octadecadienoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57958", "l": "dimethyl sulfone + H2O + NAD(+) => dimethyl sulfoxide + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72174", "l": "2 Na(+)(out) + taurohyocholate(out) <=> 2 Na(+)(in) + taurohyocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726875", "l": "HCNs:cAMP bind SNIs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46700", "l": "(R)-lipoate + GTP + H(+) = (R)-lipoyl-GMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69355", "l": "2 (E)-prop-1-en-1-SO-peroxol <=> H2O + thiosulfinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848751", "l": "PTK6 binds AKT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66561", "l": "(R)-noradrenaline + L-glutaminyl-[protein] => 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000513", "l": "actin severing activator activity", "d": ["Binds to and increases the activity of a actin severing protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928657", "l": "MMP2,9 cleave EPHB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66478", "l": "gypsogenate 28-beta-D-glucoside + UDP => gypsogenate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60987", "l": "16-hydroxyhexadecanoate + NAD(+) <=> 16-oxohexadecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49460", "l": "(2Z,4E)-2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.99.11", "l": "\"2-aminomuconate deaminase (2-hydroxymuconate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33965", "l": "ADP + isopentenyl diphosphate => ATP + isopentenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013143", "l": "RAC1 GEFs activate RAC1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.-", "l": "\"alpha-Amino-acyl-peptide hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75500", "l": "cholate(out) + n H(+)(out) => cholate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685985", "l": "EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56917", "l": "3beta-hydroxy-5alpha-androstan-17-one + NADP(+) => 5alpha-androstan-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68914", "l": "DNA polymerase alpha:primase binds at the origin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44000", "l": "2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2 = 2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16356", "l": "2-oxoglutarate + taurine <=> L-glutamate + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420131", "l": "The PACAP receptor binds PACAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877153", "l": "STARD7 binds PC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937613", "l": "CRHBP binds CRH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51271", "l": "norbelladine + S-adenosyl-L-methionine <=> 4'-O-methylnorbelladine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33233", "l": "heme d cis-diol => H2O2 + heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55673", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine => 4-O-([2-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102374", "l": "ursolic aldehyde 28-monooxygenase activity", "d": ["Catalysis of the reaction: ursolic aldehyde + NADPH + O2 + H+ = ursolic acid + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28915", "l": "4-aminobutanoate(in) + H(+)(in) = 4-aminobutanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629918", "l": "NEIL1 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31717", "l": "11alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10454", "l": "(R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase] => 2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19993", "l": "[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70994", "l": "SDH complex dehydrogenates succinate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1671691", "l": "PRLR-bound STAT5 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17297", "l": "2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA", "d": [], "t": []}, {"i": "EC:1.2.7.3", "l": "\"2-oxoglutarate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865107", "l": "MICAL1 produces NADP+, H2O2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57960", "l": "dimethyl sulfide + H(+) + NADH + O2 = dimethyl sulfoxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371435", "l": "Constitutive phosphorylation by GSK3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17769", "l": "choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.7", "l": "\"choline monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15440", "l": "a long-chain fatty aldehyde + CoA + NADP(+) <=> a long-chain fatty acyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170964", "l": "FRS2 binds to active TrkA receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31909", "l": "(S)-coclaurine + H(+) + S-adenosyl-L-homocysteine => (S)-norcoclaurine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75081", "l": "Formation of AT-AC B Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917696", "l": "Cargo Sequestration (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73477", "l": "D-arginine(out) + L-ornithine(in) => D-arginine(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34167", "l": "2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.19", "l": "\"2,6-dihydroxypseudooxynicotine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21090", "l": "a flavonol + CO2 + H2O + succinate => 2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140585", "l": "promoter-enhancer loop anchoring activity", "d": ["Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352385", "l": "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848124", "l": "PTK6 phosphorylates STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44063", "l": "2-O-sulfo-alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O-sulfo-2'-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.7.2", "l": "\"guanosine-3',5'-bis(diphosphate) 3'-diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043804", "l": "imidazolone hydrolase activity", "d": ["Catalysis of the reaction: N-formimidoylglycine => H2O + imidazol-4-one."], "t": []}, {"i": "RHEA:24935", "l": "H2O + imidazol-4-one = N-formimidoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56526", "l": "AH2 + heme d1 => A + dihydro-heme d1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14649", "l": "demethyllactenocin + dTDP-beta-L-mycarose = demethylmacrocin + dTDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.318", "l": "\"demethyllactenocin mycarosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11285", "l": "hydroxymalonate + NAD(+) => H(+) + NADH + oxomalonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102990", "l": "5-n-alk(en)ylresorcinol O-methyltransferase activity", "d": ["Catalysis of the reaction: 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine = H+ + 5-(pentadeca-8,11,14-trien-1-yl)resorcinol monomethyl ether + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380869", "l": "Release of docked dopamine loaded synaptic vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5359451", "l": "NNMT transfers CH3 from SAM to NAM to form MNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609740", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2B (GRIN2B) and GluN3B (GRIN3B) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34853", "l": "3-oxoadipyl-CoA + H(+) + NADH => (3S)-3-hydroxyadipyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40207", "l": "(2E)-tetradecenedioyl-CoA + H2O = (3S)-hydroxytetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420243", "l": "GHRH receptor binds GHRH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16253", "l": "(3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = H(+) + NADH + phenanthrene-3,4-diol", "d": [], "t": []}, {"i": "EC:1.3.1.49", "l": "\"cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6781840", "l": "ERCC6 binds stalled RNA Pol II (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.15", "l": "\"chlorophyllide a reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20100", "l": "D-mannonate <=> 2-dehydro-3-deoxy-D-gluconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49298", "l": "L-histidyl-[protein] + L-sorbose 1-phosphate(in) => keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372717", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13975", "l": "2 H(+)(out) + 2 phosphate => diphosphate + H(+)(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32044", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => 2 ATP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12517", "l": "(2E,6E)-farnesyl diphosphate => (+)-(R)-germacrene A + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76554", "l": "acetyl-CoA + D-aspartate <=> CoA + H(+) + N-acetyl-D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70982", "l": "FH tetramer hydrates fumarate to L-malate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31237", "l": "(4R)-4-hydroxy-2-oxoglutarate + L-glutamate => (4S)-4-hydroxy-L-glutamate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174119", "l": "Free APC/C phosphorylated by Plk1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825754", "l": "HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720473", "l": "Defective ALG3 does not add mannose to the N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450325", "l": "c-FOS activation by phospho ERK1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0043395", "l": "heparan sulfate proteoglycan binding", "d": ["Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727305", "l": "mRNA8 is translated to protein 8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72979", "l": "didemethylasterriquinone D + dimethylallyl diphosphate = asterriquinone C1 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.6", "l": "\"chalcone isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32984", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018127", "l": "NAD(P)-serine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22421", "l": "cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) => 2 H(+) + maleylacetate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64668", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76917", "l": "3-methylcyclohexanone + H(+) + NADPH + NH4(+) => (1S)-3-methyl-cyclohexylamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36249", "l": "(E)-anethole + H(+) + S-adenosyl-L-homocysteine => (E)-anol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33415", "l": "bornane-2,6-dione + H2O = [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)", "d": [], "t": []}, {"i": "EC:3.7.1.18", "l": "\"6-oxocamphor hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34858", "l": "2 H2O + iminodiacetonitrile <=> N-(cyanomethyl)glycine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9656891", "l": "OPN1SW binds 11cRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9774168", "l": "CDH19 gene expression is stimulated by ZC3H12A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800797", "l": "The PIDDosome activates CASP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-561072", "l": "OCT3 mediates renal uptake of organic cations (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37024", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032841", "l": "Activated NTRK2 binds CDK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086081", "l": "cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication", "d": ["Binding to a protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033447", "l": "AGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AGA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64533", "l": "an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990698", "l": "palmitoleoyltransferase activity", "d": ["Catalysis of the transfer of a palmitoleoyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68088", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] = a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59040", "l": "4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45658", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42496", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate = 10-deacetyl-2-debenzoylbaccatin III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34636", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 => H2O + NADP(+) + pentalenolactone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75996", "l": "3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) => 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008412", "l": "CDK4 phosphorylates RUNX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75080", "l": "24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 32-hydroxy-24,25-dihydrolanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52805", "l": "(2E,6E)-farnesyl diphosphate => (+)-eremophilene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27604", "l": "di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate => (2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046962", "l": "sodium-transporting ATPase activity, rotational mechanism", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out), by a rotational mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73419", "l": "L-glutamine(out) = L-glutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209566", "l": "TRAF6 is auto-ubiquitinated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48260", "l": "a ganglioside GM1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32445", "l": "all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5627775", "l": "Autophosphorylation of PAK1,2,3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24503", "l": "adenosine 5'-tetraphosphate + H2O <=> ATP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46497", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) => N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050637", "l": "lovastatin nonaketide synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H+ + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO2 + 9 CoA + dihydromonacolin L + 6 H2O + 11 NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41400", "l": "1-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388809", "l": "CTLA-4 binds B7-1/B7-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36257", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38585", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670416", "l": "Recruitment of STATs by KIT mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805546", "l": "Keratin type I binds keratin type II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687107", "l": "MAPK4,6 translocate to nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64083", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O <=> 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65000", "l": "holo-[ACP] + octanoyl-AMP = AMP + H(+) + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72947", "l": "acetate(out) + 2 Na(+)(out) = acetate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43163", "l": "adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912790", "l": "CBL binds CRK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23479", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) <=> (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12416", "l": "beta-alanyl-CoA = acryloyl-CoA + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.6", "l": "\"beta-alanyl-CoA ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58832", "l": "24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}, {"i": "EC:1.14.18.10", "l": "\"plant 4,4-dimethylsterol C-4alpha-methyl-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35895", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21252", "l": "(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2", "d": [], "t": []}, {"i": "EC:1.1.99.2", "l": "\"L-2-hydroxyglutarate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50032", "l": "H2O + hexadecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-hexadecanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43783", "l": "2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20661", "l": "D-alanyl-D-alanine + H2O = 2 D-alanine", "d": [], "t": []}, {"i": "EC:3.4.13.22", "l": "\"D-Ala-D-Ala dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78888", "l": "H2O + N-deacetylisoipecoside => D-glucose + N-deacetylisoipecoside aglycone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13190", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O => 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22220", "l": "ent-copalyl diphosphate = diphosphate + ent-kaur-16-ene", "d": [], "t": []}, {"i": "EC:4.2.3.19", "l": "\"ent-kaurene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112396", "l": "Separation of elongating transcript from template (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56539", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + 1,2-di-(12R-hydroxy-9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(12R-hydroxy-9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2018659", "l": "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0004511", "l": "tyrosine 3-monooxygenase activity", "d": ["Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13275", "l": "6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749253", "l": "Formation of MCM2-7 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610720", "l": "PKA phosphorylates GLI3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110322", "l": "Formation of Pol zeta complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78386", "l": "L-cysteinyl-[SCAN] + S-nitroso-CoA <=> CoA + S-nitroso-L-cysteinyl-[SCAN]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18718", "l": "3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine => 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937369", "l": "ATAD2 binds ESR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65316", "l": "2-oxoglutarate + chrodrimanin H + O2 = chrodrimanin E + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102895", "l": "colneleate synthase activity", "d": ["Catalysis of the reaction: 9(S)-HPODE = colneleate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20888", "l": "3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.4", "l": "\"3-hydroxyisobutyryl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696183", "l": "AOC3 deaminates BZAM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210444", "l": "L-Glutamate loading of synaptic vesicle (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9825782", "l": "p-S207 KARS1 dimer binds MITF-M:HINT1 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59712", "l": "D-maltotetraono-1,5-lactone + H2O = D-maltotetraonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50812", "l": "androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49090", "l": "FADH2 + hydroxysqualene => FAD + H(+) + H2O + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32542", "l": "(2E)-geranyl diphosphate <=> (+)-car-3-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810643", "l": "EPPIN protein complex binds bacteria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395517", "l": "NADPH transfers electrons to FDXR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2562526", "l": "PLK1 phosphorylates OPTN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72973", "l": "5-oxo-L-proline(in) + 2 Na(+)(in) => 5-oxo-L-proline(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.7", "l": "\"ferric-chelate reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604629", "l": "FBXW7 promotes ubiquitination of p-NICD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.55", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818682", "l": "MEN1 binds MLL2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700662", "l": "Liganded-ALK dimer binds type I ALK-binding TKIs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865667", "l": "LIPA hydrolyses sterol esters to sterols and fatty acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74377", "l": "H2O2(in) => H2O2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382096", "l": "Formation of NR-NCOR Corepressor Complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49055", "l": "asperlicin C + H(+) + NADH + O2 <=> asperlicin E + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44731", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358513", "l": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44035", "l": "9,10-epoxy-(12Z)-octadecenoate + H2O <=> 9,10-dihydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353356", "l": "Reversal of Alkylation Damage By DNA Dioxygenases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0140940", "l": "histone H2A methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a histone H2 = S-adenosyl-L-homocysteine + a methylated histone H2A. Histone methylation generally occurs on either an arginine or a lysine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46040", "l": "2'-deoxycytidine + ATP = ADP + dCMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29535", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.260", "l": "\"dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38683", "l": "ATP + H2O + sphing-4-enine(in) = ADP + H(+) + phosphate + sphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35815", "l": "4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46175", "l": "ATP + butanoate + CoA <=> AMP + butanoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0034979", "l": "NAD-dependent protein lysine deacetylase activity", "d": ["Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825406", "l": "SNAI2 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34694", "l": "(R)-lactoyl-CoA <=> acryloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26034", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,3'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2995334", "l": "COX15 transforms heme O to heme A (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.-", "l": "\"Aminopeptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50859", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72642", "l": "1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine <=> 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53742", "l": "[Rab1 protein]-L-tyrosine + AMP + H(+) => [Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331324", "l": "E2F1 binds BBC3 (PUMA) promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31424", "l": "(2Z,6E)-farnesyl diphosphate => (-)-alpha-cedrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22938", "l": "acetate + D-glucosamine 6-phosphate => H2O + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209096", "l": "E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68914", "l": "DNA polymerase alpha:primase binds at the origin (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53866", "l": "7,12-dioxo-lithocholate + H(+) + NADPH => 3alpha,7beta-dihydroxy-12-oxo-5beta-cholan-24-oate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74707", "l": "Binding of IRS to insulin receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693111", "l": "RHOF auto-activates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156723", "l": "Regulation of KIF20A (MKL2) by phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5591052", "l": "PROCR binds Protein C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75475", "l": "D-mannose(out) + n Na(+)(out) = D-mannose(in) + n Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42495", "l": "3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2 <=> 3'-N-debenzoyltaxol + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55571", "l": "4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine <=> 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65474", "l": "CoA + ethyl 2-methylbutanoate => 2-methylbutanoyl-CoA + ethanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805126", "l": "AURKB phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74848", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + ATP => 3-diphospho-1D-myo-inositol 1,2,4,5-tetrakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9010815", "l": "SLITs bind keratan sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30152", "l": "FADH2 + NADP(+) => FAD + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102038", "l": "4-nitrobenzyl alcohol oxidase activity", "d": ["Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 = 4-nitrobenzaldehyde + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9690461", "l": "FKBP1A binds tacrolimus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47777", "l": "guanosine(1145) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(1145) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322025", "l": "Autoglucosylation of GYG1 complexed with GYS1-a (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31845", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA => 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65662", "l": "AH2 + calcidiol => A + calciol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250220", "l": "Homodimerization of ERBB4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018770", "l": "6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity", "d": ["Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9761421", "l": "CDH11 associates with catenins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59237", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + isoelisabethatriene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41126", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65007", "l": "ATP + decanoate + holo-[ACP] <=> AMP + decanoyl-[ACP] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4167501", "l": "An unknown protease degrades ACACB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58360", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 = (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15196", "l": "dGTP + H2O <=> 2'-deoxyguanosine + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29185", "l": "2 H(+) + menaquinone-8 + 2 superoxide => menaquinol-8 + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-996755", "l": "ZFPM proteins bind GATA proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849882", "l": "SALMs 1-4 bind reticulon 3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985799", "l": "SLIT1 binds ROBO1,(ROBO2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38277", "l": "acetyl-CoA + pyruvate => (3R)-citramalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35056", "l": "3,6-dichlorocatechol + O2 => (2E,4E)-2,5-dichloromuconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55322", "l": "2-heptanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl heptanoate + apo--[retinol-binding protein] => 1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60858", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21991", "l": "malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside <=> 4'''-demalonylsalvianin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20120", "l": "ATP + L-rhamnulose <=> ADP + H(+) + L-rhamnulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38876", "l": "uridine(2604) in 23S rRNA => pseudouridine(2604) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656214", "l": "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042929", "l": "ferrichrome transmembrane transporter activity", "d": ["Enables the directed movement of a ferrichrome from one side of a membrane to the other. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23967", "l": "(E)-coniferaldehyde + H2O + NADP(+) <=> (E)-ferulate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40043", "l": "ATP + citrate + L-glutamate = ADP + beta-citrylglutamate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.1.17", "l": "\"beta-citrylglutamate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9762333", "l": "ANGPTL4 binds to CDH11v (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874138", "l": "ATF6B (ATF6-beta) translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20557", "l": "2 H(+) + H2O + urea = CO2 + 2 NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.5", "l": "\"urease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72720", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-[(R)-dihydrolipoyl]-5'-AMP => AMP + 2 H(+) + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002055", "l": "adenine binding", "d": ["Binding to adenine, a purine base."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997237", "l": "SH2B proteins bind JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77494", "l": "3,3-dimethylbutan-2-one + hydrogen cyanide <=> (2S)-2-hydroxy-2-methyl-3,3-dimethylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56882", "l": "a 3-oxo-Delta(5)-steroid + H(+) + NADPH => a 3beta-hydroxy-Delta(5)-steroid + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202325", "l": "Recruitment of Gads to LAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49524", "l": "2-oxoglutarate + an N(6)-methyl-2'-deoxyadenosine in DNA + O2 = a 2'-deoxyadenosine in DNA + CO2 + formaldehyde + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.51", "l": "\"DNA N(6)-methyladenine demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097429", "l": "amino acid ligation activity by nonribosomal peptide synthase", "d": ["Catalysis of the ligation of an amino acid to another amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate, carried out by a nonribosomal peptide synthase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51077", "l": "2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate => 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434989", "l": "SEMA7A binds to PLXNC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16993", "l": "6 Fe(III)-[cytochrome c] + 3 H2O + S-disulfanyl-L-cysteinyl-[SoxY protein] = 6 Fe(II)-[cytochrome c] + 7 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": [], "t": []}, {"i": "EC:1.8.2.6", "l": "\"S-disulfanyl-L-cysteine oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374686", "l": "L1 interaction with Integrins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50135", "l": "ethyl hexadecanoate + H2O <=> ethanol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18441", "l": "D-dopachrome + H(+) = 5,6-dihydroxyindole + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.84", "l": "\"D-dopachrome decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13323", "l": "3-methyl-2-oxobutanoate + CO2 + NADH => (R)-3,3-dimethylmalate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0019912", "l": "cyclin-dependent protein kinase activating kinase activity", "d": ["Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682026", "l": "MRN bound to shortened telomeres activates ATM (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139952", "l": "Caspase-8 processing in the DISC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51424", "l": "a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16183", "l": "3',4',5-trihydroxy-3,7-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71503", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in) = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0034353", "l": "mRNA 5'-diphosphatase activity", "d": ["Catalysis of the removal of a 5' terminal diphosphate from the 5'-triphosphate end of an mRNA, leaving a 5'-monophosphate end."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47727", "l": "glutathione <=> 5-oxo-L-proline + L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9707683", "l": "PGRMC2 binds Hemes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25675", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34537", "l": "1-deoxy-3-dehydrosphinganine + CO2 + CoA => H(+) + hexadecanoyl-CoA + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864105", "l": "PTPN18 binds ERBB2:EGFR heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111264", "l": "Addition of nucleotides between position +11 and +30 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20498", "l": "a 2-arylethylamine + acetyl-CoA => an N-acetyl-2-arylethylamine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202437", "l": "Phosphorylation of CARMA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112379", "l": "Recruitment of elongation factors to form elongation complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034012", "l": "FAD-AMP lyase (cyclizing) activity", "d": ["Catalysis of the reaction: FAD = AMP + H+ + riboflavin cyclic-4',5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097657", "l": "3',5'-nucleotide bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 3',5'-nucleoside bisphosphate + H20 = 5'-nucleoside monophosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29190", "l": "succinate + ubiquinone-8 <=> fumarate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712079", "l": "ALK mutants bind STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849032", "l": "PTK6 phosphorylates KHDRBS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54365", "l": "2 acetaldehyde => acetoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433804", "l": "IKK epsilon is recruited to the Viral dsRNA:TLR3:TICAM1 complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209910", "l": "Iodide is taken up by thyroid epithelial cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015640", "l": "peptidoglycan peptide transmembrane transporter activity", "d": ["Enables the transfer of peptidoglycan peptides from one side of a membrane to the other. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14979", "l": "3-carboxy-cis,cis-muconate => 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46685", "l": "3-oxochol-4-en-24-oyl-CoA + A => (22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66835", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> diphosphate + preasperterpenoid A", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-532549", "l": "MPI isomerises Fru6P to Man6P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428273", "l": "SPHK1 phosphorylates sphingoid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44797", "l": "2-demethylmenaquinol-13 + S-adenosyl-L-methionine => H(+) + menaquinol-13 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9704248", "l": "CHRM4 binds CHRM4 antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73864", "l": "dopamine(out) => dopamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61581", "l": "(3S)-3-hydroxycyclohexane-1-carbonyl-CoA + NADP(+) => (5S)-5-hydroxycyclohex-1-ene-1-carbonyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9726949", "l": "PTGIR binds PTGIR agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374664", "l": "Phosphorylation and activation of Ezrin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855206", "l": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49273", "l": "alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase] => calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54002", "l": "(11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62449", "l": "holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP => AMP + H(+) + L-glutamyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874078", "l": "PTK2 autophosphorylates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12638", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102450", "l": "kaempferide 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine = 7,4'-dimethylkaempferol + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396029", "l": "Latent TGF-beta-3 binds integrins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72671", "l": "eIF5B:GTP is hydrolyzed and released (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4719447", "l": "PIAS2-2 SUMOylates THRA with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14434", "l": "a tRNA precursor + ATP + 2 CTP => a tRNA with a 3' CCA end + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381608", "l": "cAMP activates EPAC2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196753", "l": "2xPPCS ligates PPanK with Cys (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52948", "l": "deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15950", "l": "(R)-2-hydroxyoctadecanoate + NAD(+) => 2-oxooctadecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53720", "l": "ATP + N-acetyl-D-muramate = ADP + H(+) + N-acetyl-alpha-D-muramate 1-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.221", "l": "\"N-acetylmuramate 1-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78101", "l": "3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+) => a 1-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67049", "l": "AH2 + chermesin D + O2 => A + asnovolin I + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213201", "l": "Formation of collagen fibres (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59676", "l": "D-maltotetraose + O2 = D-maltotetraono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170844", "l": "Latent TGF-beta-1 is cleaved by FURIN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202717", "l": "Heterodimerization of CEACAMs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70333", "l": "KHK dimer phosphorylates Fru to Fru 1-P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71691", "l": "glycyl-L-glutamate(out) + 2 H(+)(out) = glycyl-L-glutamate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29258", "l": "Ca(2+)(in) + Na(+)(out) <=> Ca(2+)(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9736953", "l": "FURIN translocates to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676595", "l": "TRAFs bind RANK:RANKL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63525", "l": "2-propylphenol + H(+) + NADH + O2 => 3-propylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52543", "l": "cytidine + phosphate <=> alpha-D-ribose 1-phosphate + cytosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10098", "l": "an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine => a fatty acyl-[ACP] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70558", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O <=> L-seryl-[protein] + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68610", "l": "Formation of ORC(2-5) complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23560", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202604", "l": "Formation of a heteromeric BMP receptor complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76560", "l": "1-(ergostan-3beta-yl)-L-aspartate + H2O => ergosterol + H(+) + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13566", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol => 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17258", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vinorine => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78518", "l": "a 5'-end (5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65045", "l": "4-cyanobenzyl alcohol + NAD(+) => 4-cyanobenzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55283", "l": "13-cis-retinol + tetradecanoyl-CoA <=> 13-cis-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10829", "l": "anthranilate + ATP + CoA => AMP + anthraniloyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69657", "l": "beta-D-glucose + quercetin => H2O + quercetin 3-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182969", "l": "Phosphorylation of CBL (EGFR:CBL) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55493", "l": "ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] => ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41084", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864569", "l": "WWOX binds TFAP2C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69820", "l": "H(+) + hypotaurine + NADPH + O2 => H2O + NADP(+) + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9859172", "l": "DLD dimer dehydrogenates dihydrolipoyl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48117", "l": "L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69279", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> but-3-enenitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44518", "l": "(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+) => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004453", "l": "juvenile-hormone esterase activity", "d": ["Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75179", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (R)-axinyssene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.209", "l": "\"(R)-axinyssene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.23.-.-", "l": "\"Reducing C-O-C group as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193709", "l": "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59177", "l": "ADP + L-serine => AMP + H(+) + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19362", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate => (2E,6E)-farnesyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61520", "l": "AH2 + dopamine = 3-tyramine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193668", "l": "p75NTR and RHOA-GDI interact (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64841", "l": "2-phenylethanol + benzoyl-CoA => CoA + phenethyl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17436", "l": "A + choline <=> AH2 + betaine aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66802", "l": "2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase] => miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74464", "l": "(-)-4'-methoxycyclopenine => 4'-methoxyviridicatin + H(+) + methyl isocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11215", "l": "indole + O2 <=> 2-formamidobenzaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004350", "l": "glutamate-5-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0032450", "l": "maltose alpha-glucosidase activity", "d": ["Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15691", "l": "CO2 + propane-1,3-diamine => H(+) + L-2,4-diaminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73678", "l": "ADP(out) + dAMP(in) + H(+)(out) <=> ADP(in) + dAMP(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102952", "l": "UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + coniferyl aldehyde = H+ + coniferaldehyde glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850534", "l": "PDCL promotes G-protein beta 5 folding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15734", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O => (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66076", "l": "2-oxopentanoate + L-kynurenine = H2O + kynurenate + L-2-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71812", "l": "3,3',5-triiodo-L-thyronine(out) => 3,3',5-triiodo-L-thyronine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090682", "l": "GPCR bitter taste receptor activity", "d": ["A G protein-coupled receptor activity that is responsible for the sense of bitter taste."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11064", "l": "beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.11", "l": "\"fructose-bisphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32414", "l": "(1R,2R,4S)-isodihydrocarveol + NAD(+) <=> (1R,4S)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38274", "l": "(3S)-citramalyl-CoA <=> 3-methylfumaryl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050079", "l": "acetylenecarboxylate hydratase activity, producing 3-oxopropanoate", "d": ["Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837136", "l": "SH binds to BCAP31 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61424", "l": "cis-cis-nepetalactol + NAD(+) = cis-cis-nepetalactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53874", "l": "CDP-D-ribose + diphosphate => CTP + D-ribose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160137", "l": "23S rRNA pseudouridine(2457) synthase activity", "d": ["Catalysis of the reaction: uridine(2457) in 23S rRNA = pseudouridine(2457) in 23S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58066", "l": "5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77145", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392195", "l": "Gi activation by P2Y purinoceptor 12 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27707", "l": "ATP + D-alanine + D-serine => ADP + D-alanyl-D-serine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22923", "l": "L-glutamine + scyllo-inosose <=> 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3322429", "l": "XIAP monoubiquinates TLE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72354", "l": "glutarate(in) + glycocholate(out) <=> glutarate(out) + glycocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085347", "l": "PIAS1 SUMOylates SAFB with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60015", "l": "a tRNA with a 3' CC end + ATP <=> a tRNA with a 3' CCA end + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090079", "l": "GLB1 hydrolyses linker chain(2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29359", "l": "H2O + UMP = phosphate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015109", "l": "chromate transmembrane transporter activity", "d": ["Enables the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3."], "t": []}, {"i": "RHEA:32819", "l": "chromate(in) = chromate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013110", "l": "RHOC binds effectors at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174660", "l": "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical  HDL + chylomicron (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37894", "l": "aclacinomycin T + H2O <=> 15-demethylaclacinomycin T + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58216", "l": "A + dihydroserpentine = AH2 + serpentine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6813626", "l": "LEAP2 binds bacteria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37760", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404134", "l": "RBP4:atROL binds TTR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948583", "l": "miR-17 microRNA binds CNOT6L mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36173", "l": "1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+) => a 1-acylglycerone 3-phosphate + a long chain fatty alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450387", "l": "HuR binds the CRM1 nuclear export machinery (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9865449", "l": "Metallochaperone inserts Cu2+ into MT-CO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050470", "l": "trimethylamine dehydrogenase activity", "d": ["Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57805", "l": "1-chloro-3-nitrobenzene + NADH + O2 => 4-chlorocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111215", "l": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4331327", "l": "E2F1 binds PMAIP1 (NOXA) promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62051", "l": "an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020258", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72016", "l": "acetyl-CoA + 2 AH2 + 9 H(+) + malate + 6 malonyl-CoA + 5 NADPH + 2 S-adenosyl-L-methionine => 2 A + 6 CO2 + 7 CoA + 6 H2O + 5 NADP(+) + 2 S-adenosyl-L-homocysteine + trihazone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-438019", "l": "activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11160", "l": "2-oxoglutarate + L-2,4-diaminobutanoate = L-aspartate 4-semialdehyde + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.76", "l": "\"diaminobutyrate--2-oxoglutarate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67224", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30501", "l": "(E)-2-methylpropanal oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-valine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050631", "l": "corydaline synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 2 NADPH + palmatine = S-adenosyl-L-homocysteine + corydaline + 2 NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445064", "l": "Activation of Rac1 by VAV2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700168", "l": "Active ALK phosphorylates IRS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044318", "l": "L-aspartate:fumarate oxidoreductase activity", "d": ["Catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650722", "l": "Translation of DDIT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2301205", "l": "SETD8 monomethylates histone H4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420593", "l": "PVR:PVRL3 trans heterodimer interaction (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20905", "l": "(S)-2-hydroxypropyl-coenzyme M => (S)-1,2-epoxypropane + coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9825751", "l": "HINT1 binds MITF-M (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72184", "l": "creatinine(in) + H(+)(out) => creatinine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72408", "l": "H(+)(in) + Li(+)(out) => H(+)(out) + Li(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18214", "l": "alpha-D-glucose 1-phosphate + CTP + H(+) => CDP-D-glucose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57832", "l": "5-oxopentanoate + H2O + NADP(+) = glutarate + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.20", "l": "\"glutarate-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3134800", "l": "STING dimerization (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-448744", "l": "IL20RA binds IL20RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4551683", "l": "SUMOylation of TOPORS with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19951", "l": "7,8-dihydropteroate + diphosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383190", "l": "HCO3- transport through ion channel (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46297", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917693", "l": "ESCRT Disassembly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71955", "l": "glutarate(out) + 3 Na(+)(out) = glutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66667", "l": "ATP + coproporphyrin III(in) + H2O <=> ADP + coproporphyrin III(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45186", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5662471", "l": "SORD tetramer oxidizes xylitol to D-xylulose (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28921", "l": "4-aminobutanoate(out) + L-glutamate(in) => 4-aminobutanoate(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701507", "l": "PTPN6 dephosphorylates JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140840", "l": "RNA polymerase II CTD heptapeptide repeat P6 isomerase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 6) = RNA polymerase II large subunit trans-proline (omega=0) (position 6)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17826", "l": "ATP + D-glucose => ADP + D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0003713", "l": "transcription coactivator activity", "d": ["A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75849", "l": "SLC25A1 exchanges CIT and MAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52306", "l": "(2S)-2-acetamido-4-aminobutanoate => H2O + L-ectoine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32897", "l": "2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51045", "l": "indole-3-pyruvate imine dimer => CO2 + NH4(+) + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11442", "l": "2,3,5,6-tetrachlorohydroquinone + H2O + NADP(+) => 2,3,5,6-tetrachlorophenol + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391933", "l": "EP3 receptor can bind PGE2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1454916", "l": "The ABCC family mediates organic anion transport (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9858752", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682020", "l": "MRN complex binds shortened telomeres (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58642", "l": "a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine => a 5'-end 5'-phospho-ribonucleoside-RNA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018850", "l": "chloromuconate cycloisomerase activity", "d": ["Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72773", "l": "7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404200", "l": "IGF1,2 binds IGF1R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69436", "l": "7-oxopregnenolone + H(+) + NADPH = 7beta-hydroxypregnenolone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551649", "l": "RANBP2 SUMOylates RANBP2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74864", "l": "(R)-salsolinol + S-adenosyl-L-methionine => H(+) + N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033295", "l": "hydroxyectoine binding", "d": ["Binding to hydroxyectoine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43608", "l": "agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.22", "l": "\"tRNA(Ile)(2)-agmatinylcytidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59378", "l": "4-amino-4-deoxyprephenate => 4-amino-4-deoxychorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55389", "l": "(3R)-3-hydroxy-2,3-dihydrotabersonine + A => (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850534", "l": "PDCL promotes G-protein beta 5 folding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67024", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.296", "l": "\"methyltransferase cap2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20296", "l": "3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) <=> 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878054", "l": "HIPK2 phosphorylates RUNX1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16268", "l": "O2 + reduced [NADPH--hemoprotein reductase] + trans-5-O-(4-coumaroyl)-D-quinate <=> 5-O-[(E)-caffeoyl]-D-quinate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034888", "l": "endosulfan monooxygenase I activity", "d": ["Catalysis of the reaction: endosulfan + O2 + 2 H+ + 2 e- = endosulfan sulfate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44446", "l": "a fatty acid + a monoacylglycerol + H(+) => a 1,2-diacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5368596", "l": "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31776", "l": "all-trans-retinyl hexadecanoate + H2O => 11-cis-retinol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42230", "l": "AH2 + estrone => 17beta-estradiol + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140799", "l": "glycine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + H+(in) = glycine(in) + H+(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17160", "l": "ATP + creatine <=> ADP + H(+) + N-phosphocreatine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984689", "l": "Kinesin-7 is a dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32506", "l": "linalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17104", "l": "H2O + O-acyl-(R)-carnitine <=> (R)-carnitine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55940", "l": "all-trans-3,4-didehydroretinol + NAD(+) = all-trans-3,4-didehydroretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8963734", "l": "IL9 binds IL9R:JAK1 and IL2RG:JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15707", "l": "2 a ubiquinol + phenylglyoxylyl-CoA => 2 a ubiquinone + H2O + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28181", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate <=> colnelenate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54994", "l": "2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 3 AH2 + CO2 + H(+) => 3 A + FMN + H2O + L-glutamate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59056", "l": "2 methanethiol + NAD(+) = dimethyl disulfide + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.8.1.21", "l": "\"dissimilatory dimethyldisulfide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73111", "l": "S-adenosyl-L-methionine + scutellarein 4'-methyl ether = ladanein + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024785", "l": "RvD1-6 translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034008", "l": "R-linalool synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = (R)-linalool + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18965", "l": "hydroxymethylbilane = H2O + uroporphyrinogen III", "d": [], "t": []}, {"i": "EC:4.2.1.75", "l": "\"uroporphyrinogen-III synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56958", "l": "H(+) + IDP + phosphoenolpyruvate => ITP + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74535", "l": "2 AH2 + 2 archaetidylglycerol + 4 S-adenosyl-L-methionine = 4 5'-deoxyadenosine + 2 A + glycerol dibiphytanyl glycerol tetraether glycerophospholipid + 4 H(+) + 4 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72410", "l": "H(+)(in) + Li(+)(out) <=> H(+)(out) + Li(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56762", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 24,25-dihydrolanosterol + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55621", "l": "a carotenoid psi-end group => a carotenoid beta-end derivative", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160136", "l": "16S rRNA pseudouridine(516) synthase activity", "d": ["Catalysis of the reaction: uridine(516) in 16S rRNA = pseudouridine(516) in 16S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106255", "l": "hydroperoxy icosatetraenoate isomerase activity", "d": ["A hydroperoxy icosatetraenoate = a hydroxy epoxy icosatrienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672948", "l": "MARK3 phosphorylates KSR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34832", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate => N-acyl-15-methylhexadecasphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.-.-", "l": "\"Acting on a sulfur group of donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9707353", "l": "CYP19A1 binds Aromatase inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017178", "l": "diphthine-ammonia ligase activity", "d": ["Catalysis of the reaction: ATP + diphthine + NH4 = ADP + diphthamide + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40301", "l": "erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41658", "l": "NADPH + sanguinarine => dihydrosanguinarine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014433", "l": "RHOG GEFs activate RHOG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202722", "l": "CD48 binds CD244 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10790", "l": "6-phospho-2-dehydro-D-gluconate + ADP + H(+) => 2-dehydro-D-gluconate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9769235", "l": "MAGED1 binds NPAS4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37372", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O => a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38180", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 19-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036050", "l": "Defective SGSH does not hydrolyse Heparan sulfate chain(2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73663", "l": "(E,E)-piperoyl-CoA + pyrrolidine = CoA + H(+) + piperyline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44330", "l": "glycerol + H(+) + octanoate => 1-octanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034946", "l": "3-isopropylbut-3-enoyl-CoA thioesterase activity", "d": ["Catalysis of the reaction: 3-isopropylbut-3-enoyl-CoA + H2O = 3-isopropylbut-3-enoic acid + CoASH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5250217", "l": "ARL2:GTP binds ARL2BP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65911", "l": "3-hydroxy-L-kynurenine + pyruvate <=> H2O + L-alanine + xanthurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706393", "l": "RHOBTB3 binds ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51675", "l": "glyoxal + H2O <=> glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69726", "l": "(indol-3-yl)acetyl-AMP + CoA <=> (indol-3-yl)acetyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71247", "l": "beta-alanine(out) + chloride(out) + 2 Na(+)(out) = beta-alanine(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35764", "l": "8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68128", "l": "a fatty acyl-CoA + phytol = a fatty acid phytyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419843", "l": "CALCA(83-119) binds CALCR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627089", "l": "CASP9 is phosphorylated at T412 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193641", "l": "IKK-beta is recruited (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38184", "l": "19-hydroxytestosterone + O2 + reduced [NADPH--hemoprotein reductase] => 19-oxotestosterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24682", "l": "5,10-methylenetetrahydromethanopterin + NADP(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53532", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate = (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791095", "l": "Expression of HERPUD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5545484", "l": "MLH1 variants-defective DNA mismatch repair (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42309", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706298", "l": "Active FLT3 binds to CSK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59599", "l": "H2O + kynuramine + O2 <=> 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171011", "l": "Binding and activation of MAP Kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043896", "l": "glucan 1,6-alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877485", "l": "RUNX1 binds to TNFRSF18 (GITR) gene promoter and intron 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9671145", "l": "DKC1 binds SHQ1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388900", "l": "Neurotensin receptors can bind neurotensins (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625421", "l": "The anterograde IFT train dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.17", "l": "\"inulin fructotransferase (DFA-I-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43606", "l": "2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380278", "l": "CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3108212", "l": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67467", "l": "H2O + propanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43828", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40394", "l": "1-O-alkyl-2-acyl-sn-glycerol + an acyl-CoA <=> 1-O-alkyl-2,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28461", "l": "biotin(in) <=> biotin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69588", "l": "inosine + UMP = IMP + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75535", "l": "FMNH2 + N-acetyl-S-methyl-L-cysteine + O2 = (R)-N-acetyl-S-methyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56669", "l": "7beta-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7beta-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17841", "l": "trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.229", "l": "\"[Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12370", "l": "2,5-didehydro-D-gluconate + AH2 => 2-dehydro-D-gluconate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67480", "l": "2-oxoglutarate + O2 + prekainate = CO2 + H2O + kainate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70250", "l": "N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose <=> beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16966", "l": "(2E)-geranyl diphosphate => beta-myrcene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004966", "l": "galanin receptor activity", "d": ["Combining with galanin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28959", "l": "D-xylose(in) + H(+)(in) = D-xylose(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878117", "l": "RUNX3 binds ZFHX3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0008169", "l": "C-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72007", "l": "succinate(in) + urate(out) = succinate(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73616", "l": "CTP(out) + dCMP(in) => CTP(in) + dCMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64348", "l": "2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) = deacetylpyripyropene E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0015166", "l": "polyol transmembrane transporter activity", "d": ["Enables the transfer of a polyol from one side of a membrane to the other. A polyol is any polyhydric alcohol."], "t": []}, {"i": "REACT:R-HSA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11964", "l": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39040", "l": "an omega-oxo fatty acid + H2O + NAD(+) => a dicarboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114671", "l": "vWF binds to collagen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166869", "l": "TRAF6 binds MEKK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66747", "l": "ATP + H2O + N-acetyl-L-aspartate(in) <=> ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199299", "l": "AKT phosphorylates FOXO transcription factors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41772", "l": "a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1b (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22344", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + (E)-caffeoyl-CoA = (R)-rosmarinate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.140", "l": "\"rosmarinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49236", "l": "N(pros)-phospho-L-histidyl-[protein](out) + sucrose = L-histidyl-[protein] + sucrose 6(G)-phosphate(in)", "d": [], "t": []}, {"i": "EC:2.7.1.211", "l": "\"protein-N(pi)-phosphohistidine--sucrose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20425", "l": "2-oxoglutarate + ATP + hydrogencarbonate = (S)-oxalosuccinate + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.4.1.7", "l": "\"2-oxoglutarate carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19280", "l": "ATP + L-pyrrolysine + tRNA(Pyl) <=> AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654399", "l": "Activated FGFR2 binds FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.50", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50424", "l": "(8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016019", "l": "peptidoglycan immune receptor activity", "d": ["Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11237", "l": "putrescine + spermidine => propane-1,3-diamine + sym-homospermidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690042", "l": "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73643", "l": "CTP(out) + IDP(in) = CTP(in) + IDP(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11823", "l": "diphthamide-[translation elongation factor 2] + NAD(+) <=> H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3076905", "l": "Extracellular BTD hydrolyses BCTN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20984", "l": "a sphingomyelin + H2O = an N-acylsphing-4-enine 1-phosphate + choline + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.41", "l": "\"sphingomyelin phosphodiesterase D\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22570", "l": "ascopyrone P => ascopyrone M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47356", "l": "an octanoate ester + H2O = an aliphatic alcohol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62784", "l": "2 fonsecin B + H(+) + NADPH + O2 = bifonsecin B + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018766", "l": "RHOU binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67362", "l": "2 L-threonine => H2O + L-threonyl-L-threonine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202127", "l": "eNOS synthesizes NO (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391150", "l": "p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31844", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA => 2-oxepin-2(3H)-ylideneacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052668", "l": "CTP:farnesol kinase activity", "d": ["Catalysis of the reaction: 2-trans,-6-trans-farnesol + CTP = 2-trans,-6-trans-farnesyl monophosphate + CDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45704", "l": "(E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17112", "l": "FMNH2 + N-methylnicotinate + O2 <=> (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52007", "l": "H2O + methylglyoxal + NAD(+) <=> 2 H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61147", "l": "myricetin + UDP-beta-L-rhamnose <=> H(+) + myricetin 3-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5333671", "l": "CLCAs self cleave (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14179", "l": "(R)-prunasin + D-glucose => (R)-amygdalin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59586", "l": "ADP + beta-alanyl-L-lysine + H(+) + phosphate => ATP + beta-alanine + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11167", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine <=> 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9838081", "l": "LONP1 degrades mitochondrial matrix proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0004690", "l": "cyclic nucleotide-dependent protein kinase activity", "d": ["cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30531", "l": "biotinate sulfoxide + H(+) + NADH = biotin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676264", "l": "Formation of the SET1B complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180540", "l": "Multi-ubiquitination of APOBEC3G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59582", "l": "CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester => hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0050456", "l": "cystine reductase activity", "d": ["Catalysis of the reaction: 2 L-cysteine + NAD+ = L-cystine + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165129", "l": "GDP is exchanged for GTP on DRheb (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769008", "l": "NOTCH1 PEST domain mutants bind DLL1  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19214", "l": "acetyl-CoA + an S-substituted L-cysteine => an N-acetyl-L-cysteine-S-conjugate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30925", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+) => (R)-glycerate + ADP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75633", "l": "plasmodiophorol C => H2O + plasmodiophorol B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37374", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end phospho (purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69344", "l": "(E)-but-1-en-1-SO-peroxol = (Z)-butanethial oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877760", "l": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39222", "l": "3-oxooctacosanyol-CoA + H(+) + NADPH <=> (3R)-hydroxyoctacosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11195", "l": "an (S)-2-haloacid + H2O <=> a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448673", "l": "Formation of caspase-1 p10/p20 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28430", "l": "D-allose 6-phosphate = D-allulose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57606", "l": "a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031802", "l": "type 5 metabotropic glutamate receptor binding", "d": ["Binding to a type 5 metabotropic glutamate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55694", "l": "1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+) => an inositol-1-phosphoceramide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16762", "l": "chlorohydroquinone + O2 => 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062046", "l": "dehydropipecolic acid reductase", "d": ["Catalysis of the reaction: dehydropipecolic acid + NAD(P)H + H+ = L-pipecolic acid + NAD(P)+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65720", "l": "2-oxoglutarate + butyl sulfate + O2 = butanal + CO2 + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001049", "l": "RNA polymerase V core binding", "d": ["Binding to RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16828", "l": "ATP + uridine <=> ADP + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050209", "l": "polyvinyl-alcohol oxidase activity", "d": ["Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42779", "l": "adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42207", "l": "corticosterone + NAD(+) <=> 11-dehydrocorticosterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27616", "l": "di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate => (2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625901", "l": "CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25476", "l": "(2E,6E)-farnesyl diphosphate = alpha-himachalene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40405", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210920", "l": "NEUROG3-dependent synthesis of NEUROD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28098", "l": "ATP + GDP = AMP + guanosine 3',5'-bis(diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12919", "l": "D-glucose + strictosidine aglycone => 3alpha(S)-strictosidine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75433", "l": "32-oxoeburicol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 32-hydroxyeburicol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "51.07771168633704", "identifiers": [{"i": "GO:0005515", "l": "protein binding", "d": ["Binding to a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759513", "l": "CDH11 canonical mRNA is translated into CDH11 canonical protein isoform (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-179417", "l": "Multiubiquitination of Nek2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56196", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-alpha-D-galactose = H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57073", "l": "3-oxoisoapionate 4-phosphate + H(+) => CO2 + L-erythrulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70761", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008239", "l": "dipeptidyl-peptidase activity", "d": ["Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77946", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate <=> 1,3-di-(9Z)-hexadecenoylglycerol + 9-(9Z-hexadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878654", "l": "ACP6 hydrolyses MYS-LPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.182", "l": "\"4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24609", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) => 2,5-dioxopentanoate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59144", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46502", "l": "CO2 + phosphate + succinate + uridine-5'-aldehyde => 2-oxoglutarate + O2 + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044875", "l": "gamma-glutamyl hercynylcysteine sulfoxide synthase activity", "d": ["Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 = gamma-glutamyl-hercynyl cysteine sulfoxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68355", "l": "pppA(2'-5')pG <=> 3',2'-cGAMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8944457", "l": "MAF1 translocates to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44421", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O => a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952625", "l": "NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78237", "l": "(R)-3-methyl-2-oxopentanoate + H2O2 + NH4(+) => D-isoleucine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043876", "l": "D-threonine aldolase activity", "d": ["Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63417", "l": "2,6-dichlorohydroquinone + FADH2 + O2 => 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71727", "l": "citrate(out) + fumarate(in) = citrate(in) + fumarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27457", "l": "3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59657", "l": "D-cellotriose + O2 => D-cellotriono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093330", "l": "EPHB binds p120-RasGAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047316", "l": "glutamine-phenylpyruvate transaminase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917730", "l": "Cargo Recognition And Sorting (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944236", "l": "Association of procollagen type XIV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75929", "l": "cyclohexanone + H(+) + NADH + NH4(+) => cyclohexylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59867", "l": "(indol-3-yl)butanoate + ATP + L-glutamine <=> (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0097108", "l": "hedgehog family protein binding", "d": ["Binding to a member of the hedgehog protein family, signaling proteins involved in development."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937177", "l": "AHR:TCDD binds ARNT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802935", "l": "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76588", "l": "(6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + 2-oxoglutarate + AH2 + H(+) + O2 => (2S)-5,5-dimethylpiperidine-2-carboxylate + A + 2 CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20818", "l": "3-oxoglycyrrhetinate + H(+) + NADPH => 3alpha-hydroxyglycyrrhetinate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0010858", "l": "calcium-dependent protein kinase regulator activity", "d": ["Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-984606", "l": "Kinesin-5 is a homotetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783552", "l": "OSM binds LIFR:JAKs,OSMR:JAKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24432", "l": "H2O + oxaloacetate = acetate + H(+) + oxalate", "d": [], "t": []}, {"i": "EC:3.7.1.1", "l": "\"oxaloacetase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67563", "l": "3'-phosphoadenylyl sulfate + taurocholate <=> adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299482", "l": "TIMM23 SORT inserts proteins into inner membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690449", "l": "S1PR1 bind S1P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204861", "l": "Interaction of Tie2 and Shc1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676133", "l": "CD74 binds MIF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390329", "l": "Dephosphorylation of AKT by PP2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16377", "l": "(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.4", "l": "\"phytochromobilin:ferredoxin oxidoreductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617896", "l": "Retinoic acid activates HOXD4 chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001863", "l": "collectin receptor activity", "d": ["Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75791", "l": "(S)-lactate(out) + Na(+)(out) = (S)-lactate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56651", "l": "3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37474", "l": "3-methylbutanoyl-CoA + S-adenosyl-L-methionine <=> CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56158", "l": "(12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.56", "l": "\"lipopolysaccharide N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1454928", "l": "ABCG4 may mediate cholesterol efflux (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.-", "l": "\"With NADH or NADPH as one donor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201630", "l": "Caspase-mediated cleavage of Acinus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443894", "l": "TXA2 is hydrolysed to TXB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9657608", "l": "Single mechanism MAPK inhibitors bind phosphorylated MAPK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672948", "l": "MARK3 phosphorylates KSR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032863", "l": "CDK5 phosphorylates NTRK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74734", "l": "Re-integration of insulin receptor into plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43758", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18] => acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140660", "l": "cytoskeletal motor activator activity", "d": ["Binds to and increases the activity of a motor protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58733", "l": "5-methyl-CTP + H2O => 5-methyl-CMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951723", "l": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16928", "l": "(E)-caffeoyl-CoA + S-adenosyl-L-methionine <=> (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44125", "l": "hexadecanoyl-CoA + tetradecan-1-ol => CoA + tetradecanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11623", "l": "H2O + L-2-amino-4-chloropent-4-enoate <=> 2-oxopent-4-enoate + chloride + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873926", "l": "IFNG dimer binds IFNGR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818937", "l": "MEN1 binds MLL1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044102", "l": "purine deoxyribosyltransferase activity", "d": ["Catalysis of deoxyribose exchange between purine deoxyribonucleoside as a donor and purine base as an acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605797", "l": "SMPD1 hydrolyzes SPHM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47215", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58651", "l": "rifamycin SV hemiaminal <=> H(+) + rifamycin SV ortho-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45130", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004062", "l": "aryl sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381612", "l": "GLP1R binds GLP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56767", "l": "12-epi-fischerindole U + 2-oxoglutarate + chloride + H(+) + O2 <=> 12-epi-fischerindole G + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18606", "l": "1-amino-1-deoxy-scyllo-inositol + ATP => 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65440", "l": "a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50297", "l": "N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + O2 + reduced [NADPH--hemoprotein reductase] => 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50302", "l": "all-trans-4-hydroxyretinol + H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466846", "l": "atRAL can spontaneously react with PE to form NRPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51351", "l": "acetyl-CoA + 10 AH2 + 2 H(+) + 7 malonyl-CoA + 5 S-adenosyl-L-methionine <=> 10 A + 7 CO2 + 8 CoA + dehydroprobetaenone I + 6 H2O + 5 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017067", "l": "tyrosine-ester sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57563", "l": "(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102320", "l": "1,8-cineole 2-exo-monooxygenase activity", "d": ["Catalysis of the reaction: 1,8-cineole + NADPH + H+ + O2 = 2-exo-hydroxy-1,8-cineole + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46424", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20704", "l": "a D-alpha-amino acid + acetyl-CoA = an N-acetyl-D-amino acid + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.36", "l": "\"D-amino-acid N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58263", "l": "H2O + O-(ADP-D-ribosyl)-L-tyrosyl-[protein] <=> ADP-D-ribose + L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54795", "l": "L-histidyl-[protein] + N(7)-methyl-GTP <=> diphosphate + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793176", "l": "DS is cleaved from its proteoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59828", "l": "H2O + S-inosyl-L-homocysteine = inosine + L-homocysteine", "d": [], "t": []}, {"i": "EC:3.13.1.9", "l": "\"S-inosyl-L-homocysteine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9763137", "l": "BRCA2 binds SEM1 (DSS1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64573", "l": "isopentenyl diphosphate + neryl diphosphate => (2Z,6Z)-farnesyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55718", "l": "(9Z)-octadecenoate + (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+) => (S,S)-2-(9Z-octadecenoyl)-sn-glycero-1-phospho-(2'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10100", "l": "a sterol ester + H2O = a fatty acid + a sterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0008308", "l": "voltage-gated monoatomic anion channel activity", "d": ["Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}, {"i": "REACT:R-HSA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61903", "l": "AH2 + betaenone C <=> A + betaenone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41301", "l": "(9Z)-octadecenoate + sphing-4-enine => H2O + N-(9Z-octadecenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176298", "l": "Activation of claspin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944227", "l": "Association of procollagen type XXII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22456", "l": "creatine + H2O = sarcosine + urea", "d": [], "t": []}, {"i": "EC:3.5.3.3", "l": "\"creatinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63427", "l": "(2S)-2-phospholactate + GTP + H(+) <=> (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69288", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate = sulfate + sulforaphane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75465", "l": "choline(in) + n H(+)(out) => choline(out) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50260", "l": "11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8953398", "l": "PIR oxygenates quercetin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13944", "l": "ATP + D-glyceraldehyde <=> ADP + D-glyceraldehyde 3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23492", "l": "UDP-alpha-D-glucosamine = UDP-alpha-D-galactosamine", "d": [], "t": []}, {"i": "EC:5.1.3.16", "l": "\"UDP-glucosamine 4-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62356", "l": "8-oxo-GDP + H2O = 8-oxo-GMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57422", "l": "H(+) + NAD(+) + 2 reduced [cytochrome P450] => NADH + 2 oxidized [cytochrome P450]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849102", "l": "SRMS phosphorylates PTK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8953013", "l": "E2F7 binds E2F8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132100", "l": "Fluid-phase proteolytic cleavage of factor B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40201", "l": "16-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28242", "l": "O2 + pratensein + reduced [NADPH--hemoprotein reductase] = 5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36949", "l": "3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA => (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047358", "l": "UDP-glucose-glycoprotein glucose phosphotransferase activity", "d": ["Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917693", "l": "ESCRT Disassembly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51821", "l": "ATP(in) + CoA(in) + decanoate(out) + H(+)(out) => AMP(in) + decanoyl-CoA(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5159250", "l": "ATF7IP binds SETDB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48009", "l": "2-hydroxybenzoyl-CoA + H(+) + NADH + O2 => 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56632", "l": "H2O + neryl diphosphate = 1,8-cineole + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52094", "l": "(9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+) => 5-(9Z-hexadecenoyloxy)-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013159", "l": "CDC42 GEFs activate CDC42 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64138", "l": "(9Z)-octadecenoate + L-asparagine => H2O + N-(9Z-octadecenoyl)-L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174070", "l": "Association of Cdh1 with the APC/C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18282", "l": "NAD(+) + succinate => fumarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404193", "l": "IGF1R phosphorylates SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11732", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B = H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.142", "l": "\"8-dimethylallylnaringenin 2'-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395992", "l": "p-T,4S-IRF3 is dimerized (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66803", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47325", "l": "(S)-3-amino-3-phenylpropanoate + pyruvate => 3-oxo-3-phenylpropanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74122", "l": "delphinidin + UDP-alpha-D-galactose <=> delphinidin 3-O-beta-D-galactoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13965", "l": "H2O + L,L-cystathionine = L-homocysteine + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785704", "l": "DSB inducing agents induce double strand DNA breaks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938371", "l": "RUNX2:CBFB binds the LGALS3 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57415", "l": "AMP + diphosphate + L-tyrosinal + NADP(+) <=> ATP + H(+) + L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047419", "l": "N-acetylgalactosamine-6-phosphate deacetylase activity", "d": ["Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32606", "l": "(6E)-8-hydroxygeraniol + NADP(+) <=> (6E)-8-oxogeraniol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12546", "l": "2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate => 2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63734", "l": "UDP + zolarsartan O-beta-D-glucuronoside => UDP-alpha-D-glucuronate + zolasartan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169406", "l": "ISGylation of host proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047000", "l": "2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + NADP+ = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034228", "l": "ethanolamine transmembrane transporter activity", "d": ["Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71188", "l": "3-hydroxy-L-kynurenine(out) + L-tryptophan(in) => 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32288", "l": "(2R,3S)-3-isopropylmalate => (2S)-2-isopropylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20875", "l": "(20S)-ginsenoside Rd + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rb1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21337", "l": "NAD(+) + pyridoxal => 4-pyridoxolactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937989", "l": "RUNX1 binds PRC1 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.752469279128519", "identifiers": [{"i": "GO:0019900", "l": "kinase binding", "d": ["Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140226", "l": "RNA topoisomerase activity", "d": ["Catalysis of the transient cleavage and passage of individual RNA strands or double helices through one another, resulting a topological transformation in RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047373", "l": "acetoxybutynylbithiophene deacetylase activity", "d": ["Catalysis of the reaction: 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49871", "l": "(+)-dehydrodiconiferyl acid + a quinone <=> (+)-dehydrodiconiferyl acid ketone + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004591", "l": "oxoglutarate dehydrogenase (succinyl-transferring) activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + lipoamide + H+ = S-succinyldihydrolipoamide + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625375", "l": "FOXO3,FOXO4 bind STK11 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14489", "l": "a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40163", "l": "D-glyceraldehyde + H2O + NADP(+) = (R)-glycerate + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.89", "l": "\"D-glyceraldehyde dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51863", "l": "(2E)-geranyl diphosphate + umbelliferone <=> 8-geranylumbelliferone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380199", "l": "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.554670414377497", "identifiers": [{"i": "GO:1901618", "l": "organic hydroxy compound transmembrane transporter activity", "d": ["Enables the transfer of organic hydroxy compound from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432378", "l": "Nuclear JET binds CRY, facilitating its ubiquitination (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602473", "l": "Autocatalytic activation of MMP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28134", "l": "(2S)-hesperidin + H2O = (2S)-hesperetin + rutinose", "d": [], "t": []}, {"i": "EC:3.2.1.168", "l": "\"hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13404", "l": "(2E,6E)-farnesol <=> (2Z,6E)-farnesol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42494", "l": "3'-N-debenzoyltaxol + A + H2O => 3'-N-debenzoyl-2'-deoxytaxol + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17101", "l": "H2O + O-acyl-(R)-carnitine = (R)-carnitine + a fatty acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.28", "l": "\"acylcarnitine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:1990239", "l": "steroid hormone binding", "d": ["Binding to a steroid hormone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4608852", "l": "SMURF1/2 ubiquitinates PRICKLE1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1629787", "l": "Synthesis of Cx26 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58193", "l": "dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin => dihydrobisanhydrobacterioruberin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63993", "l": "5-fluorocytidine + ATP => 5-fluorocytidine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507719", "l": "p62:MEKK3 binds to TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790029", "l": "Expression of PTGS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48274", "l": "2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein] => 2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008503", "l": "benzodiazepine receptor activity", "d": ["Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64550", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP] => N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12346", "l": "H(+) + L-glutamyl-tRNA(Glu) + NADPH => (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031695", "l": "alpha-2B adrenergic receptor binding", "d": ["Binding to an alpha-2B adrenergic receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34511", "l": "N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.290", "l": "\"N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22830", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+) => 1-(5-phospho-beta-D-ribosyl)-ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.27", "l": "\"sphinganine-1-phosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755304", "l": "MUL1 ubiquitinates UBXN7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40936", "l": "a 1-acylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25878", "l": "H2O2 + iminosuccinate => L-aspartate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.80", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35868", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55702", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H(+) + mannosyldiinositol-1-phosphate => an inositol phosphomannosylinositol-1-phospho-N-acyl-(4R)-4-hydroxysphinganine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45929", "l": "15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36759", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine = alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.306", "l": "\"UDP-GalNAc:alpha-D-GalNAc-diphosphoundecaprenol alpha-1,3-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202328", "l": "Translocation of PKC theta to plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78648", "l": "ATP + S-sulfanyl-L-cysteine + tRNA(Cys) => (S)-sulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785565", "l": "Defective B3GALTL does not transfer glucose to O-fucosyl-proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78916", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA => a long-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22871", "l": "3-chloro-L-alanine + thioglycolate <=> chloride + H(+) + S-carboxymethyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41824", "l": "3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40906", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65803", "l": "a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O <=> a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+) + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103003", "l": "oleate peroxygenase activity", "d": ["Catalysis of the reaction: oleate + a lipid hydroperoxide = 9,10-epoxystearate + a lipid alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31749", "l": "3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH => 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66096", "l": "3-phenylpyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678854", "l": "S1PR1 binds S1PR1 agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2173778", "l": "MSR1 (SCARA1, SR-A) binds ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694439", "l": "COPII coat binds TRAPPCII and RAB1:GDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634943", "l": "MyrG-CDK5R1 binds CDK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193695", "l": "IRAK interacts with TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612444", "l": "ERBB4s80 binds STMN1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420883", "l": "Opsins act as GEFs for G alpha-t (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9648268", "l": "HTR1A binds HTR1A antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16930", "l": "2 benzoyl-CoA + L-ornithine => 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099619", "l": "UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011289", "l": "ZSWIM8 binds ROBO3.1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19482", "l": "acetyl-CoA + succinyl-CoA => 3-oxoadipyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68309", "l": "1D-myo-inositol hexakisphosphate + H2O => 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2562541", "l": "TLR4-induced ripoptosome assembly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19707", "l": "H(+) + hexadecanoyl-CoA + NADH => CoA + hexadecanal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674093", "l": "PDGFRs bind type I TKI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.20", "l": "\"aminopeptidase Ey\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18301", "l": "ATP + NH4(+) + XMP = AMP + diphosphate + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11513", "l": "salicyl alcohol + UDP-alpha-D-glucose => H(+) + salicin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13403", "l": "(2Z,6E)-farnesol => (2E,6E)-farnesol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14151", "l": "H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP => luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57001", "l": "acetyl-CoA + streptothricin F => CoA + H(+) + N(beta)-acetylstreptothricin F", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606564", "l": "GALC hydrolyzes GalCer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72228", "l": "chloride(out) + 2 Na(+)(out) + sarcosine(out) => chloride(in) + 2 Na(+)(in) + sarcosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16371", "l": "H(+) + NADH + pyruvate => (R)-lactate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54796", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) = an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.412", "l": "\"2-alkyl-3-oxoalkanoate reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47290", "l": "7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.24", "l": "\"aminopeptidase S\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683925", "l": "ULK1 is dephosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306876", "l": "NLRP3 activation by small molecules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199112", "l": "CRTAM binds to NECL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031857", "l": "type 1 parathyroid hormone receptor binding", "d": ["Binding to a type 1 parathyroid hormone receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78917", "l": "a long-chain (2E)-enoyl-CoA + H2O => a long-chain (3S)-3-hydroxy fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56122", "l": "3-(all-trans-heptaprenyl)benzene-1,2-diol + H2O + NADP(+) => 2-all-trans-heptaprenylphenol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14768", "l": "coelenterazine h + O2 <=> CO2 + excited coelenteramide h monoanion + H(+) + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10278", "l": "1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66732", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008822", "l": "PPM1D dephosphorylates RUNX2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36725", "l": "2-phenylacetaldehyde + AH2 + NH4(+) => 2-phenylethylamine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675473", "l": "SH2B binds JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59478", "l": "2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol => 2 AH2 + 2 ATP + benzoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429016", "l": "ALOX5 is phosphorylated by MAPKAP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74610", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-galactosamine(out) <=> UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592398", "l": "Activation of proMMP8 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71620", "l": "(S)-malate(in) + 2 thiosulfate(out) => (S)-malate(out) + 2 thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38595", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938217", "l": "RUNX1 binds the SWI/SNF complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50007", "l": "H(+) + NADPH + O2 + tetracycline <=> 11a-hydroxytetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390846", "l": "D2D3,4 bind to DA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44899", "l": "a N-(2-hydroxyacyl)sphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxyacyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58192", "l": "dimethylallyl diphosphate + H2O + isopentenyldehydrorhodopin = dihydrobisanhydrobacterioruberin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64620", "l": "(E)-sinapyl alcohol + acetyl-CoA = (E)-sinapoyl actetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46339", "l": "3-oxochola-4,17-dien-22-oyl-CoA + H2O <=> 17-hydroxy-3-oxochol-4-en-22-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19868", "l": "4 H(+) + uroporphyrinogen III <=> 4 CO2 + coproporphyrinogen III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9825790", "l": "p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34950", "l": "(Z)-3-aminoacrylate + H(+) + H2O <=> 3-oxopropanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70933", "l": "chloride(in) + dopamine(in) + 2 Na(+)(in) => chloride(out) + dopamine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426155", "l": "SREBP1A,2 binds the DHCR7 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64240", "l": "glycine + octanoyl-CoA = CoA + H(+) + N-octanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209156", "l": "MYD88 binds to TUB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692437", "l": "ANG binds F-actin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58415", "l": "3 H(+) + hydrogen sulfide + L-aspartate 4-semialdehyde + reduced 2[4Fe-4S]-[ferredoxin] <=> H2O + L-homocysteine + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46689", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA + A => 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204465", "l": "Basigin interacts with CD43 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51141", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 => (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13155", "l": "2-hydroxy-3-oxosuccinate + 2 H(+) + NADH => (R)-glycerate + CO2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391936", "l": "EP1 receptor can bind PGE2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64211", "l": "an N-(fatty acyl)-L-glutamine + H2O <=> a fatty acid + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.5", "l": "\"L-threonine aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604738", "l": "Active FLT3 dimer binds GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13029", "l": "H2O + N-acetyl-D-glucosamine + O2 = H(+) + H2O2 + N-acetyl-D-glucosaminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43215", "l": "adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65318", "l": "chrodrimanin E + CO2 + H2O + succinate => 2-oxoglutarate + chrodrimanin H + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34699", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-isocomene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.136", "l": "\"alpha-isocomene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38250", "l": "(9Z)-hexadecenoyl-CoA + hexadecan-1-ol <=> 1-O-hexadecyl (9Z)-hexadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28201", "l": "(S)-1-phenylethanol + NAD(+) <=> acetophenone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9749253", "l": "Formation of MCM2-7 complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56326", "l": "2'-deoxyribonucleotide-DNA + H(+) + S-methyl-L-cysteinyl-[protein] => (2'-deoxyribonucleoside 5'-methylphosphotriester)-DNA + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878220", "l": "RUNX3 binds the NOTCH1 coactivator complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57749", "l": "2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH => C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010471", "l": "GDP-galactose:mannose-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: GDP-beta-L-galactose + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + beta-L-galactose-1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42615", "l": "a plastoquinone + (n+1) H(+)(in) + NADPH <=> a plastoquinol + n H(+)(out) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67776", "l": "a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H2O = a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61435", "l": "(R)-8-oxocitronellyl enol + NADP(+) <=> (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050233", "l": "pyranose oxidase activity", "d": ["Catalysis of the reaction: D-glucose + O2 = 2-dehydro-D-glucose + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29146", "l": "a ubiquinol + 2 H(+)(in) + nitrate <=> a ubiquinone + 2 H(+)(out) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3858475", "l": "ppDVL recruits RAC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75352", "l": "2 Fe(III)-[cytochrome c] + H2O + pseudooxynicotine => 4-oxo-4-(pyridin-3-yl)butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10746", "l": "3,4-dihydroxybenzoate + CO2 + NADH => (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5633460", "l": "MDM2 binds TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070909", "l": "glutamate:gamma-aminobutyric acid antiporter activity", "d": ["Catalysis of the reaction: glutamate(out) + gamma-aminobutyric acid(in) = glutamate(in) + gamma-aminobutyric acid(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11350", "l": "ADP + arsenite(out) + H(+) + phosphate => arsenite(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52874", "l": "17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP => 17alpha-estradiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689861", "l": "Recruitment of XPA and release of CAK  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047877", "l": "ephedrine dehydrogenase activity", "d": ["Catalysis of the reaction: (1R,2S)-ephedrine + NAD+ = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15783", "l": "3-amino-3-(4-hydroxyphenyl)propanoate => L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68921", "l": "ATP + H(+) + NADPH + pentanoate => AMP + diphosphate + NADP(+) + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140431", "l": "DNA-(abasic site) binding", "d": ["Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607746", "l": "PKC-delta is activated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16848", "l": "acetyl-CoA + H2O + oxaloacetate <=> citrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140753", "l": "linear 1,3-beta-D-glucan synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + a linear [(1->3)-beta-D-glucosyl](n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021357", "l": "PRKCI phosphorylates ELF3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23445", "l": "(S)-lactate + NAD(+) => H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192475", "l": "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44154", "l": "myo-inositol + phosphate => 1D-myo-inositol 2-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21581", "l": "(2S)-2-acetolactate + H(+) => (R)-acetoin + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42343", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NAD(+) <=> 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18531", "l": "3-methylbutanal + H(+) + NADH => 3-methylbutanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64255", "l": "glycine + tetradecanoyl-CoA <=> CoA + H(+) + N-tetradecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22879", "l": "(R)-mandelamide + H2O <=> (R)-mandelate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77712", "l": "Fe(III)-heme b-[protein] + H2O + nitric oxide => Fe(II)-heme b-[protein] + 2 H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.69", "l": "\"biflaviolin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-984671", "l": "Chromokinesins form dimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12633", "l": "benzoate + H(+) + NADH + O2 = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.10", "l": "\"benzoate 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33231", "l": "H2O2 + heme b = heme d cis-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45057", "l": "deoxynogalonate + O2 => H(+) + H2O + nogalonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37684", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA => 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28472", "l": "pyridoxine(out) => pyridoxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399939", "l": "Autophosphorylation of PAK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34053", "l": "6'''-deamino-6'''-hydroxyneomycin C + acetate => 2'''-acetyl-6'''-hydroxyneomycin C + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199050", "l": "ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9838035", "l": "CLPXP binds mitochondrial matrix proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38795", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295599", "l": "SPRY2 translocates to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696146", "l": "AOC2 deaminates TYR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66638", "l": "(-)-alpha-acorenol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009936", "l": "RNASEL cleaves cellular ssRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.217", "l": "\"exo-acting protein-alpha-N-acetylgalactosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28256", "l": "(3Z)-hex-3-en-1-yl acetate + CoA => (3Z)-hex-3-en-1-ol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45194", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44925", "l": "2-oxoadipate + acetyl-CoA + H2O => (R)-dihomocitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68093", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA => a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18724", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate <=> diphosphate + ent-13-epi-manoyl oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015264", "l": "methylammonium channel activity", "d": ["Enables the energy-independent facilitated diffusion of methylammonium through a transmembrane aqueous pore or channel. Methylammonium is CH3NH2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57458", "l": "4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP => (E)-sinapate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0070273", "l": "phosphatidylinositol-4-phosphate binding", "d": ["Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74734", "l": "Re-integration of insulin receptor into plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33648", "l": "(9Z)-hexadecenoate + ATP + CoA => (9Z)-hexadecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657051", "l": "OGG1beta G12E does not translocate to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54440", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + H(+) = a 4-H-anthocyanidin with a 3-hydroxy group + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44158", "l": "myo-inositol + phosphate => 1D-myo-inositol 5-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60209", "l": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 => 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9865350", "l": "Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190263", "l": "FGFR3b binds to FGF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52139", "l": "a 5'-end guanosine-5'-diphospho-5'-(2'-deoxyribonucleoside)-DNA + H2O <=> a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59633", "l": "D-xylobiose + O2 => D-xylobiono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032582", "l": "Activated FYN binds GRIN2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61839", "l": "ergosterol + UDP-alpha-D-glucose <=> ergosteryl 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69261", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate => (3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694441", "l": "CSNK1D phosphorylates SEC23 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047272", "l": "phosphopolyprenol glucosyltransferase activity", "d": ["Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110218", "l": "Cleavage of uracil by TDG glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38216", "l": "D-glucose 6-phosphate + NAD(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003711", "l": "transcription elongation factor activity", "d": ["A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45773", "l": "[(1->4)-beta-D-mannosyl](n) + phosphate => [(1->4)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266303", "l": "Spherical HDL binds C and E apolipoproteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10093", "l": "a 2'-deoxyribonucleoside 3'-phosphate + H2O => a 2'-deoxyribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981728", "l": "Factor H binds to membrane-associated C3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993802", "l": "HLCS biotinylates PC:Mn2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20330", "l": "ATP + L-seryl-[low-density-lipoprotein receptor] => ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56924", "l": "ATP + L-threonyl-[Goodpasture antigen-binding protein] = ADP + H(+) + O-phospho-L-threonyl-[Goodpasture antigen-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12522", "l": "(E)-caffeate + NH4(+) => L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71393", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in) => 16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029453", "l": "Phosphorylation of VAV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015127", "l": "bilirubin transmembrane transporter activity", "d": ["Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018594", "l": "MECP2 binds LBR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36636", "l": "4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809309", "l": "MTMR6 binds MTMR9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62646", "l": "(5S)-hydroperoxy-(6E,8Z)-eicosadienoate => (5Z,8Z)-eicosadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69133", "l": "cadaverine + H2O + O2 => 5-aminopentanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26313", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = dihydroxyacetone phosphate + L-aspartate 4-semialdehyde", "d": [], "t": []}, {"i": "EC:4.1.2.56", "l": "\"2-amino-4,5-dihydroxy-6-oxo-7-(phosphonooxy)heptanoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62266", "l": "hydrogencarbonate(in) + selenite(in) + Zn(2+)(in) => hydrogencarbonate(out) + selenite(out) + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69173", "l": "Joining of adjacent Okazaki fragments (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52086", "l": "13-hydroxy-octadecanoate + H(+) + octadecanoate => 13-octadecanoyloxy-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13009", "l": "H2O + N-formyl-L-kynurenine = formate + H(+) + L-kynurenine", "d": [], "t": []}, {"i": "EC:3.5.1.9", "l": "\"arylformamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31155", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + 2 H2O + NAD(+) = (4S)-4-hydroxy-L-glutamate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73644", "l": "CTP(out) + IDP(in) => CTP(in) + IDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873924", "l": "Phosphorylation of IFNGR1 by JAK kinases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13736", "l": "an n-alkanal + NAD(+) <=> an alk-2-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47287", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62650", "l": "(5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate => (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12765", "l": "CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482932", "l": "PI is hydrolyzed to 2-acyl LPI by PLA2[13] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63100", "l": "H(+) + ilicicolin C + NADPH + O2 = ascochlorin + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46759", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65041", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51241", "l": "(9Z,12Z)-octadecadienoate + O2 => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50118", "l": "CoA + H(+) + N-eicosanoyl-taurine => eicosanoyl-CoA + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73556", "l": "(E,E)-feruperate + O2 + reduced [NADPH--hemoprotein reductase] => (E,E)-piperate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27803", "l": "(2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate => all-trans-decaprenyl diphosphate + 7 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13414", "l": "ADP + thymidine => AMP + dTMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000327", "l": "PLK1 phosphorylates BORA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66357", "l": "(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+) => (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694641", "l": "Viral release (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013004", "l": "RHOA binds effectors at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112755", "l": "SOCS3 binds IL6ST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41483", "l": "an acyl-CoA + episterol <=> an episterol ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111930", "l": "Adenylate cyclase produces cAMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31031", "l": "2-cis-(+)-abscisate + UDP-alpha-D-glucose = beta-D-glucopyranosyl cis-(+)-abscisate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75748", "l": "10-oxooctadecanoate + H(+) + NADH => 10-hydroxyoctadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63575", "l": "H2O + neurotensin-(1-8) <=> L-arginine + neurotensin-(1-7)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879201", "l": "Bcl-2 and Bcl-XL bind NLRP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38070", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA <=> 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031756", "l": "Edg-3 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-3 sphingosine 1-phosphate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453358", "l": "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21618", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59445", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene + A => 1,1'-dihydroxy-3,4-didehydro-1,2-dihydrolycopene + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-434989", "l": "SEMA7A binds to PLXNC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694583", "l": "ABHD4 hydrolyses NAPE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73827", "l": "an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090079", "l": "GLB1 hydrolyses linker chain(2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218804", "l": "p38 MAPK activation by VEGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000411", "l": "RANBP2 SUMOylates PML with SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013004", "l": "RHOA binds effectors at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216202", "l": "Phosphorylated SMO changes conformation and is activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15344", "l": "ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide <=> ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15573", "l": "N-acetylserotonin + S-adenosyl-L-methionine = H(+) + melatonin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.4", "l": "\"acetylserotonin O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853320", "l": "FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67128", "l": "5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH = (1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724670", "l": "C-ter TLR7 dimer binds imiquimod (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76147", "l": "perivine + S-adenosyl-L-methionine = 2 H(+) + S-adenosyl-L-homocysteine + vobasine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63096", "l": "ilicicolin A epoxide = ilicicolin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11773", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35642", "l": "(4S)-4-hydroxy-2-oxoglutarate <=> glyoxylate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61792", "l": "ATP + L-tryptophan = diphosphate + L-tryptophyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17123", "l": "H(+) + L-homocitrulline + phosphate => carbamoyl phosphate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008466", "l": "glycogenin glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37227", "l": "(E,E)-sorbate + H(+) = (E)-1,3-pentadiene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67882", "l": "adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+) => 3'-phosphoadenylyl sulfate + dopamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67432", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12787", "l": "an aldose + H(+) + NADH => an alditol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663271", "l": "NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72674", "l": "6-hydroxyphenazine-1-carboxylate + 2 H(+) + NADH + O2 <=> 1,6-dihydroxyphenazine + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24145", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA => 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70534", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30515", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = H(+) + S-methyl-5'-thioadenosine + thermospermine", "d": [], "t": []}, {"i": "EC:2.5.1.79", "l": "\"thermospermine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936563", "l": "ISGylation of DDX58 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24687", "l": "H2O + N-formylmethanofuran => formate + methanofuran", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475022", "l": "Carbonic anhydrase dehydrates bicarbonate (cytosol) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5615668", "l": "AKR1C3 reduces atRAL to atROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804229", "l": "JMY, TTC5 and EP300 bind (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806419", "l": "TP53 binds the FANCC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461971", "l": "Alpha-defensin dimers adsorb onto microbial membrane anionic phospholipids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73049", "l": "guanidinoacetate(out) => guanidinoacetate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428885", "l": "Activation of CLASP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429101", "l": "HMIT co-transports myo-inositol with a proton (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72938", "l": "(S)-lactate(out) + 2 Na(+)(out) <=> (S)-lactate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47593", "l": "a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GP1c (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141409", "l": "Mad1 binds kinetochore (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70492", "l": "GDP-beta-L-fucose + L-threonyl-[protein] => 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12232", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) = [thioredoxin]-dithiol + glycine + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:1.21.4.2", "l": "\"glycine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685950", "l": "Endocytosis of protein 3a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174444", "l": "Formation of C-strand Okazaki fragments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070007", "l": "glutamic-type endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696131", "l": "AOC1 deaminates Hist (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56284", "l": "a (3R,4R)-4,2'-dihydroxyisoflavan + NADP(+) = a (3R)-2'-hydroxyisoflavanone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37697", "l": "1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928615", "l": "EFNBs bind SFKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35198", "l": "L-quinate(in) <=> L-quinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022911", "l": "CSPG is secreted (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45105", "l": "6-demethylmitomycin A + S-adenosyl-L-methionine => mitomycin A + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75322", "l": "chloride(out) + D-alanine(out) + 2 Na(+)(out) <=> chloride(in) + D-alanine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047893", "l": "flavonol 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.773497473658765", "identifiers": [{"i": "GO:0016803", "l": "ether hydrolase activity", "d": ["Catalysis of the hydrolysis of an ether bond, -O-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24192", "l": "(2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50102", "l": "CoA + H(+) + N-dodecanoyl-taurine => dodecanoyl-CoA + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12493", "l": "L-methionine => D-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19420", "l": "[phosphate](n) + a dolichyl diphosphate <=> [phosphate](n+1) + a dolichyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034347", "l": "type III interferon binding", "d": ["Binding to a type III interferon. Interferon lambda is the only member of the type III interferon found so far."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218832", "l": "CDC42:GTP binds PAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592278", "l": "Autocatalytic activation of proMMP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60915", "l": "cytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-methionine <=> H(+) + N(3)-methylcytidine(32) in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183055", "l": "Binding of CBL to EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67569", "l": "3'-phosphoadenylyl sulfate + taurochenodeoxycholate => adenosine 3',5'-bisphosphate + H(+) + taurochenodeoxycholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30386", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-7-epi-alpha-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24333", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate => H2O + monacolin L carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106371", "l": "fluorescent chlorophyll catabolite monooxygenase (deformylase) activity", "d": ["Catalysis of the reaction: O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] = formate + 2 H+ + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite."], "t": []}, {"i": "RHEA:67172", "l": "O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] = formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.25", "l": "\"mitogen-activated protein kinase kinase kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13439", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + UDP => (E)-cinnamate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980233", "l": "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43882", "l": "(25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate => (25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51361", "l": "H2O + N-(9Z-octadecenoyl)-L-leucine => (9Z)-octadecenoate + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28394", "l": "L-alanyl-L-glutamate = L-alanyl-D-glutamate", "d": [], "t": []}, {"i": "EC:5.1.1.20", "l": "\"L-Ala-D/L-Glu epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130619", "l": "TGN-lysosomal vesicle coat assembly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043738", "l": "reduced coenzyme F420 dehydrogenase activity", "d": ["Catalysis of the reaction: methanophenazine + reduced coenzyme F420 = dihydromethanophenazine + coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71129", "l": "H(+)(out) + L-glutamine(in) + Na(+)(in) => H(+)(in) + L-glutamine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21460", "l": "benzoin = 2 benzaldehyde", "d": [], "t": []}, {"i": "EC:4.1.2.38", "l": "\"benzoin aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14493", "l": "H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] = ADP-D-ribose + L-arginyl-[dinitrogen reductase]", "d": [], "t": []}, {"i": "EC:3.2.2.24", "l": "\"ADP-ribosyl-[dinitrogen reductase] hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183094", "l": "CDC42:GTP binds CBL:Beta-Pix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3321805", "l": "NSL acetylates histone H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45392", "l": "H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54792", "l": "L-histidyl-[protein] + N(7)-methyl-GTP = diphosphate + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30146", "l": "H2O + octanoyl-CoA <=> CoA + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647978", "l": "pro-RAS proteins are farnesylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23120", "l": "a dipeptide(out) + ATP + H2O = a dipeptide(in) + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.4.2.9", "l": "\"ABC-type dipeptide transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102360", "l": "daphnetin 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 7,8-dihydroxycoumarin = UDP(3-) + 3-O-beta-D-glucosyl-daphnetin + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75426", "l": "(R,S)-butane-2,3-diol + NAD(+) <=> (R)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42537", "l": "uridine(65) in tRNA => pseudouridine(65) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71477", "l": "L-isoleucyl-L-leucine + neurotensin(1-11) => H2O + neurotensin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047480", "l": "UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65204", "l": "(3R)-3-hydroxybutanoyl-CoA + H2O = (R)-3-hydroxybutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848975", "l": "PTK6 phosphorylates KHDRBS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45871", "l": "9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982775", "l": "Growth hormone receptor dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166869", "l": "TRAF6 binds MEKK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68690", "l": "3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69382", "l": "4-methyl-2-oxopentanoate + H2O2 => 2-hydroxy-4-methylpentanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295622", "l": "SPRY2 binds CBL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9842666", "l": "Active LTK phosphorylates IRS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49867", "l": "(+)-dehydrodiconiferyl acid + 2 a quinone + H2O <=> (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863007", "l": "p25-bound CDK5 phosphorylates CDC25B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63311", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 11-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690494", "l": "RHOB translocates to the endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64476", "l": "4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate = 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42600", "l": "AH2 + prostaglandin G2 = A + H2O + prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162187", "l": "COQ6 hydroxylates DHB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75015", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hexadecanoyloxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757441", "l": "ASA- (GI) translocates from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38390", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1,3-di-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40033", "l": "diphosphate + ent-manool => ent-copalyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788622", "l": "p-Y-STATs dimerize (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265422", "l": "Interaction of integrin alphaEbeta7 with Cadherin-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37956", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (8R)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853762", "l": "RET dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416690", "l": "SEMA4A binds to PLXND1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54388", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64499", "l": "3,5,7,9,11-pentaoxododecanoyl-[ACP] <=> 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47468", "l": "(2E,4E)-tetradecadienoyl-CoA = (3E,5Z)-tetradecadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016900", "l": "oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule."], "t": []}, {"i": "EC:1.1.4.-", "l": "\"With a disulfide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106418", "l": "UDP-N-acetylmuramate-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate ligase activity", "d": ["Catalysis of the reaction: ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63643", "l": "H2O + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NAD(+) <=> 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032931", "l": "histone H3K56 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5336443", "l": "LIN7, CASK and APBA1 bind (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3595178", "l": "Defective CHSY1 does not transfer GlcA to chondroitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37405", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10026", "l": "H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine => L-lysyl-[histone] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70714", "l": "D-alanine(in) <=> D-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10338", "l": "D-threo-isocitrate => citrate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008684", "l": "TBK1 phosphorylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18667", "l": "(2R)-3-phosphoglycerate + [phosphate](n+1) => (2R)-3-phospho-glyceroyl phosphate + [phosphate](n)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.112", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3149519", "l": "MMACHC decyanates CNCbl (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73191", "l": "(2R,3S,11R)-aszonalenin + acetyl-CoA = (2R,3S,11R)-acetylaszonalenin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74865", "l": "H(+) + N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine => (R)-salsolinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0005499", "l": "vitamin D binding", "d": ["Binding to vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21801", "l": "all-trans-antheraxanthin + L-ascorbate => all-trans-zeaxanthin + H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28285", "l": "(S)-beta-bisabolene <=> (S)-beta-macrocarpene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51068", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate = (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57100", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thio-D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71895", "l": "dGTP + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30435", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly)", "d": [], "t": []}, {"i": "EC:2.3.2.16", "l": "\"lipid II:glycine glycyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44272", "l": "3 H(+) + 3 malonyl-CoA + octadecanoyl-CoA = 4-hydroxy-6-(2-oxononadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052737", "l": "pyruvate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645501", "l": "TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56698", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate => D-ribulose 5-phosphate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809521", "l": "BPIF binds bacteria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203613", "l": "depalmitoylation of eNOS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37414", "l": "aklavinone + NADP(+) <=> aklaviketone + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57376", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.166", "l": "\"(S)-N-methylcanadine 1-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514790", "l": "Elastin degradation by MMP14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.107", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047662", "l": "aminobenzoate decarboxylase activity", "d": ["Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68703", "l": "16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77453", "l": "(2S)-2-(2H-1,3-benzodioxol-5-yl)-2-hydroxyacetonitrile => hydrogen cyanide + piperonal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69948", "l": "3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22177", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76407", "l": "H2O + Xaa-L-Pro dipeptide = an L-alpha-amino acid + L-proline", "d": [], "t": []}, {"i": "EC:3.4.13.9", "l": "\"Xaa-Pro dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63891", "l": "hexadecanoyl-CoA + sphinga-4E,14Z-dienine <=> CoA + H(+) + N-hexadecanoyl-sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48016", "l": "4-methyl-5-nitrocatechol + NADH + O2 = 2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33885", "l": "3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH => 2-deoxy-scyllo-inosamine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57997", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose => (20S)-ginsenoside Rh2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034914", "l": "trinitrophenol hydride denitratase activity", "d": ["Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex = 2,4-dinitrophenol + nitrite. Trinitrophenol is also known as TNP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22325", "l": "H2O + leukotriene A4 => leukotriene B4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873919", "l": "Phosphorylation of JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10827", "l": "(S)-malate + NADP(+) <=> H(+) + NADPH + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034949", "l": "1,1-dichloroethane reductive dehalogenase activity", "d": ["Catalysis of the reaction: 1,1-dichloroethane + 2 H+ + 2 e- = chloroethane + HCl."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55107", "l": "3-oxoheptanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyheptanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0035673", "l": "oligopeptide transmembrane transporter activity", "d": ["Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166041", "l": "Transfer of LPS onto TLR4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987040", "l": "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47489", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isodeoxycholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.78", "l": "\"phylloquinone omega-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866321", "l": "VLDL binds APOC1 and APOC4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47821", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702510", "l": "FLT mutants bind type II TKIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50618", "l": "(3E)-nonen-2-one + H(+) + NADPH => NADP(+) + nonan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0015927", "l": "trehalase activity", "d": ["Catalysis of the hydrolysis of trehalose or a trehalose derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39098", "l": "(3S)-hydroxydecanedioyl-CoA + NAD(+) <=> 3-oxodecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31139", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = 3-hydroxy-3-methyl-2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177930", "l": "GAB1 phosphorylation by EGFR kinase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972960", "l": "POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700156", "l": "Active ALK dimer binds IRS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75541", "l": "(2E)-decenoyl-[ACP] + AMP + diphosphate => (2E)-decenoate + ATP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59821", "l": "2 ATP => adenosine 3'-diphosphate,5'-triphosphate + AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11374", "l": "AMP + diphosphate + H(+) + L-asparagine => ATP + L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40548", "l": "10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909718", "l": "Formation of p-STAT1 homodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57564", "l": "(+)-cis-trans-nepetalactol + O2 + reduced [NADPH--hemoprotein reductase] = 7-deoxyloganetic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55183", "l": "2-oxoglutarate + 3-methylnonanoyl-CoA + O2 <=> 2-hydroxy-3-methylnonanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66800", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + miltiradien-20-al + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17438", "l": "2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate => (2E,4E)-2,4-dichloromuconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851112", "l": "NPM1-ALK- and TYK2-dependent MCL1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54082", "l": "5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine => 5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62181", "l": "H2O + peregrinol diphosphate => diphosphate + viteagnusin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71870", "l": "glycodeoxycholate(out) <=> glycodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018768", "l": "RHOU auto-activates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975100", "l": "Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76041", "l": "7-hydroxy-8-methoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.0(4,9).0(16,20)]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cis-N-methyltetrahydrothalifendine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75739", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH = 10-oxooctadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112434", "l": "Formation of DSIF complex  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2152276", "l": "Secretion of transmembrane collagens (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627089", "l": "CASP9 is phosphorylated at T412 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11991", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine <=> 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0051912", "l": "CoB--CoM heterodisulfide reductase activity", "d": ["Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35591", "l": "H2 + n sulfur = H(+) + hydrogen sulfide + (n-1) sulfur", "d": [], "t": []}, {"i": "EC:1.12.98.4", "l": "\"sulfhydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46854", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholest-8-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19794", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + oxidized [electron-transfer flavoprotein] + sarcosine => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + glycine + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191072", "l": "Synthesis of Cx43 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749215", "l": "MCM8 binds CDC6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78534", "l": "beta-D-glucosylceramide + H2O <=> a  beta-D-glucosyll-(1<->1')-sphingoid base + a fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807106", "l": "PTEN undergoes monoubiquitination (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77397", "l": "(2S)-2-hydroxybutanenitrile => hydrogen cyanide + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-919404", "l": "Phosphorylated STAT5 is released (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49405", "l": "beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate => alpha-D-mannose 1-phosphate + D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16804", "l": "3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] <=> adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46964", "l": "lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate", "d": [], "t": []}, {"i": "EC:1.1.1.436", "l": "\"lactate dehydrogenase (NAD(+),ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839388", "l": "TGFBR3 translocation to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656213", "l": "RAF1 mutants show enhanced heterodimerization with BRAF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112510", "l": "IL6ST is tyrosine phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102851", "l": "1-18:2-2-16:0-phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42438", "l": "L-ascorbate 6-phosphate(in) + L-histidyl-[protein] => L-ascorbate(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56914", "l": "(E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH => (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009558", "l": "IL34 dimer binds SDC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444476", "l": "FPRL2 receptor binds a wide range of ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50877", "l": "a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH => a hydroxy polyunsaturated fatty acid + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853444", "l": "AURKA phosphorylates PHLDA1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33646", "l": "(9Z)-tetradecenoate + ATP + CoA <=> (9Z)-tetradecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517846", "l": "TLR2-1 :TLR1-1 binds to triacyl lipopeptide (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030772", "l": "tryptophan 2-C-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5221061", "l": "TDG excises 5-carboxylcytosine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199298", "l": "AKT phosphorylates CREB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16764", "l": "chlorohydroquinone + O2 <=> 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68826", "l": "(Z)-beta-ocimene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008123", "l": "cholesterol 7-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18597", "l": "H(+) + NAD(+) + 2 reduced [rubredoxin] = NADH + 2 oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8858252", "l": "HDLBP binds HDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15913", "l": "ATP + thiamine phosphate = ADP + thiamine diphosphate", "d": [], "t": []}, {"i": "EC:2.7.4.16", "l": "\"thiamine-phosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77679", "l": "a globoside MSGG (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a globoside DSGG (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22673", "l": "2 (2E,6E)-farnesyl diphosphate => diphosphate + presqualene diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614614", "l": "Cysteine is degraded to serine and H2S (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655170", "l": "RCHY1 monoubiquitinates POLH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102585", "l": "cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + malonyl-CoA + H+ = cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674529", "l": "AAMP binds to TBXA2R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797803", "l": "PTPRD binds SLITRK1-6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76566", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acylsphing-14Z-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71692", "l": "glycyl-L-glutamate(out) + 2 H(+)(out) => glycyl-L-glutamate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865280", "l": "TFAP2C homodimer binds the CDKN1A (p21) gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225949", "l": "Binding of CBL to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507870", "l": "Aquaporins passively transport water out of cells (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48129", "l": "(2E,6E)-farnesyl diphosphate + H2O => (2E,6E)-farnesyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28339", "l": "(R)-carnitinyl-CoA => crotonobetainyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71599", "l": "2-oxoglutarate(out) + maleate(in) = 2-oxoglutarate(in) + maleate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806629", "l": "Formation of tonofilament bundles (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008861", "l": "formate C-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64617", "l": "(E)-coniferol + acetyl-CoA => (E)-coniferyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199203", "l": "PANK1/3 phosphorylate PanK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9660557", "l": "RAS:GTP binds RAL GDS proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64544", "l": "acetyl-CoA + 8 AH2 + ATP + 4 H(+) + holo-[ACP] + L-tyrosine + 7 malonyl-CoA + 2 S-adenosyl-L-methionine = 8 A + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0004345", "l": "glucose-6-phosphate dehydrogenase activity", "d": ["Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21523", "l": "2 Fe(III)-[cytochrome b1] + formate <=> CO2 + 2 Fe(II)-[cytochrome b1] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22582", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + H2O => (S)-4-hydroxy-2-oxopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44360", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.32", "l": "\"(4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660538", "l": "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162192", "l": "COQ2 ligates all-E-10PrP2 to PHB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61823", "l": "3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose <=> epiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090590", "l": "protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + D-glucosamine(out) = protein histidine + glucosamine-6-phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17676", "l": "quercetin + S-adenosyl-L-methionine <=> 3',4',5,7-tetrahydroxy-3-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11342", "l": "4-guanidinobutanal + CO2 => 5-guanidino-2-oxopentanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78235", "l": "D-isoleucine + H2O + O2 = (R)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64446", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381091", "l": "IRE1 dimer autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140345", "l": "phosphatidylcholine flippase activity", "d": ["Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17936", "l": "a 7-hydroxyisoflavone + S-adenosyl-L-methionine <=> a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351901", "l": "Caspase-mediated cleavage of MST3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110322", "l": "Formation of Pol zeta complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928625", "l": "PAKs autophosphorylate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5676637", "l": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420131", "l": "The PACAP receptor binds PACAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52822", "l": "CoA + O-succinyl-L-serine => L-serine + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507873", "l": "Aquaporins passively transport urea out of cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0160128", "l": "pH-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an inorganic ion by a channel that opens in response to a change in proton concentration (pH)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786421", "l": "CHIA hydrolyses chitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31699", "l": "4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] = 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": [], "t": []}, {"i": "EC:1.14.15.32", "l": "\"pentalenene oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35404", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) => (3R)-vestitone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67999", "l": "(Z)-1,2-dichloroethene + AH2 <=> A + chloride + chloroethene + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53283", "l": "D-threose <=> D-erythrulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75981", "l": "argipressin(in) => argipressin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948027", "l": "RNASEs bind bacterial phospholipids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018682", "l": "atrazine N-dealkylase activity", "d": ["Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756724", "l": "p-2S-SMAD2,3:TRIM33, p-2S-SMAD2,3:SMAD4, CTNNB1, EOMES, and TBPL2 bind FOXH1:MIXL1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72804", "l": "L-arginine(out) + N(omega)-methyl-L-arginine(in) => L-arginine(in) + N(omega)-methyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33588", "l": "acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate => CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25730", "l": "N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66998", "l": "2-methylpentanoyl-CoA + AMP + diphosphate => 2-methylpentanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2471670", "l": "Defective RDH12 does not reduce atRAL to atROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851933", "l": "MET phosphorylates GAB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38720", "l": "(R)-carnitine(out) + ATP + H2O => (R)-carnitine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52300", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64449", "l": "L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45445", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-sn-glycero-3-phosphoethanolamine => H(+) + N-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl ethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17075", "l": "CoA + cortisol 21-acetate => acetyl-CoA + cortisol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65705", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose => alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13907", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37558", "l": "D-kanosamine 6-phosphate + H2O <=> kanosamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050224", "l": "prunasin beta-glucosidase activity", "d": ["Catalysis of the reaction: (R)-prunasin + H2O = D-glucose + mandelonitrile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9860169", "l": "Binding of MyoD to TGFBR3 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40448", "l": "(2R)-pristanoyl-CoA => (2S)-pristanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022941", "l": "MECP2 binds GAD2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47614", "l": "a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + H(+) + UDP => a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16054", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine => H(+) + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.042693372152272", "identifiers": [{"i": "GO:0090599", "l": "alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805126", "l": "AURKB phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44170", "l": "dodecanal + H2O + NAD(+) => dodecanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12817", "l": "2,3-dihydrobiochanin A + NADP(+) = biochanin A + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.46", "l": "\"biochanin-A reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24929", "l": "NH4(+) + pyruvate + S-sulfanyl-L-cysteine => H2O + L-cystine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16865", "l": "choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25553", "l": "9alpha-copalyl diphosphate => diphosphate + stemar-13-ene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434990", "l": "SEMA7A binds to integrin alpha1beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855648", "l": "SALM3 binds LAR-RPTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49739", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate <=> CO2 + deoxyviolacein + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76778", "l": "decan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,7-decanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982775", "l": "Growth hormone receptor dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51016", "l": "7,8-dihydroneopterin 3'-phosphate = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde phosphate", "d": [], "t": []}, {"i": "EC:4.1.2.59", "l": "\"dihydroneopterin phosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.155", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015054", "l": "gastrin receptor activity", "d": ["Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047180", "l": "salutaridinol 7-O-acetyltransferase activity", "d": ["Catalysis of the reaction: (7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156930", "l": "GTP-binding activates eEF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74533", "l": "2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaetidylglycerol => AH2 + archaetidylglycerol + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14500", "l": "A + pyridoxine <=> AH2 + isopyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.430", "l": "\"D-xylose reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693598", "l": "ATM phosphorylates NBN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58388", "l": "4-aminobenzoate + all-trans-hexaprenyl diphosphate = 4-amino-3-all-trans-hexaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42768", "l": "a (2S)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39588", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379387", "l": "COMT transfers Met to DA to form 3MT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30717", "l": "(S)-linalool => (2E)-geraniol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22848", "l": "(3S)-hydroxyoctanedioyl-CoA + NAD(+) = 3-oxooctanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033722", "l": "malonate-semialdehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23514", "l": "beta-D-glucose 1-phosphate + D-glucose => alpha,alpha-trehalose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1358790", "l": "RNF41 ubiquitinates ERBB3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51935", "l": "2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite <=> 2 Fe(II)-[cytochrome c3] + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32179", "l": "(S)-2,3-dihydrodipicolinate + NAD(+) = dipicolinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0019863", "l": "IgE binding", "d": ["Binding to an immunoglobulin of the IgE isotype."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39456", "l": "(2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40773", "l": "(20S)-ginsenoside F1 + D-glucose => (20S)-ginsenoside Rg1 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395768", "l": "LPL hydrolyses TGs from mature CMs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461995", "l": "pro-defensin alpha 5 is stored in Paneth cell granules (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871265", "l": "YAP1 binds TEAD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77290", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840807", "l": "OPTN binds ATG9A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30943", "l": "FAD + H(+) + octanoyl-CoA = (2E)-octenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754644", "l": "SARS-CoV-2 E pentamer binds TJP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43286", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37861", "l": "1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20709", "l": "ATP + erythritol => ADP + D-erythritol 4-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22782", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805122", "l": "AURKB binds TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791184", "l": "Expression of ATP6VOD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25881", "l": "2 L-dopa + O2 => 2 3-(3,4-dihydroxyphenyl)pyruvate + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27414", "l": "2-oxoglutarate + codeine + O2 => CO2 + formaldehyde + morphine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16446", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone => daidzein + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9698844", "l": "MLKL binds HSP90:CDC37 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801666", "l": "PLK2 phosphorylates CENPJ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0003917", "l": "DNA topoisomerase type I (single strand cut, ATP-independent) activity", "d": ["Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67381", "l": "H2O + L-alanyl-L-cysteine => L-alanine + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9639286", "l": "RRAGC,D exchanges GTP for GDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0046923", "l": "ER retention sequence binding", "d": ["Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51215", "l": "(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) <=> 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70843", "l": "L-arginine(in) + L-methionine(out) + Na(+)(out) = L-arginine(out) + L-methionine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54071", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O <=> diphosphate + sesterfisherol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730902", "l": "Oligomerization of p-CARMA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390438", "l": "FAR2 reduces PalmCoA to HXOL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14118", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O => [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.1", "l": "\"DNA ligase (ATP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031754", "l": "Edg-1 sphingosine 1-phosphate receptor binding", "d": ["Binding to an Edg-1 sphingosine 1-phosphate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39237", "l": "(2E)-triacontenoyl-CoA + H2O => (3R)-hydroxytriacontanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47174", "l": "5alpha-cholest-8-en-3-one + CO2 + NADH => 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008965", "l": "phosphoenolpyruvate-protein phosphotransferase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350158", "l": "LGMN degrades GC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11689", "l": "ATP + L-leucine + tRNA(Leu) => AMP + diphosphate + L-leucyl-tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63024", "l": "(13Z)-docosenamide + H2O = (13Z)-docosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651773", "l": "LIG1 binds POLB at long-patch BER site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793485", "l": "PRKN polyubiquitinates RIPK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018785", "l": "RHOBTB2 binds GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.110", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71023", "l": "L-leucine(in) + L-phenylalanine(out) = L-leucine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30439", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": [], "t": []}, {"i": "EC:2.3.2.17", "l": "\"N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733314", "l": "CSF1R trans-autophosphorylates on tyrosine-561 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63465", "l": "(2E,6E,10E)-geranylgeraniol + UTP => (2E,6E,10E)-geranylgeranyl phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735302", "l": "GATA4, GATA6, and ISL1:LDB1 bind the HAND2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64441", "l": "glycylglycyl-L-proline(out) + H(+)(out) => glycylglycyl-L-proline(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17349", "l": "(2E)-geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole = 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.146", "l": "\"3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632677", "l": "PTCH is internalized (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372542", "l": "Loading of dopamine into synaptic veiscles (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24883", "l": "(S)-1-pyrroline-5-carboxylate + 2 H2O + NADP(+) => H(+) + L-glutamate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41247", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 9R-hydroperoxy(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17641", "l": "H(+) + L-arginine = agmatine + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.19", "l": "\"arginine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43470", "l": "(8Z,10E,14Z)-12-hydroperoxyeicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836606", "l": "SPHK1 binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48077", "l": "a primary alcohol + N,N-dimethyl-4-nitrosoaniline => 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419490", "l": "Binding of ATP to P2X receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190829", "l": "Lysosomal degradation of gap junction plaques (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655142", "l": "RCHY1 binds POLH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55335", "l": "a 3'-hydroxyflavone + S-adenosyl-L-methionine <=> a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19131", "l": "ADP + dTMP + H(+) => ATP + thymidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49088", "l": "FAD + H(+) + H2O + squalene = FADH2 + hydroxysqualene", "d": [], "t": []}, {"i": "EC:1.17.8.1", "l": "\"hydroxysqualene dehydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700149", "l": "Active ALK binds PLCG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592398", "l": "Activation of proMMP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517850", "l": "TLR2-1 : TLR1-2 heterodimer binds to its ligand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56455", "l": "3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole <=> 12-epi-hapalindole U", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48284", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = a globoside NOR1 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24782", "l": "CO2 + pyropheophorbide a => C-13(2)-carboxypyropheophorbide a + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22566", "l": "a (2E)-enoyl-[ACP] + H(+) + NADPH => a 2,3-saturated acyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616367", "l": "NAB2 binds EGR1 to repress CDK5R1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12689", "l": "2 mycothiol + NAD(+) = H(+) + mycothione + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050109", "l": "morphine 6-dehydrogenase activity", "d": ["Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-418553", "l": "cAMP degradation by Phosphodiesterases (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665727", "l": "FMNL2 binds CDC42:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46680", "l": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)", "d": [], "t": []}, {"i": "EC:1.6.2.2", "l": "\"cytochrome-b5 reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11406", "l": "UDP-alpha-D-galacturonate => UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9825783", "l": "p-S207 KARS1 dimer translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047258", "l": "sphingosine beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: sphingosine + UDP-D-galactose = H+ + psychosine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433592", "l": "sphinganine + stearyl-CoA => dihydroceramide + CoASH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034953", "l": "perillyl-CoA hydratase activity", "d": ["Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783880", "l": "PIPOX oxidises PPCA to P6C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204873", "l": "Interaction of Tie2 and Shp2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20158", "l": "a polyvinyl alcohol + 2n Fe(III)-[cytochrome c] => an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202375", "l": "Recruitment of ITK to SLP-76 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109813", "l": "GRB2-1 binds SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088130", "l": "PLK1 binds FOXM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76597", "l": "a dicarboxylate(out) + sulfate(in) => a dicarboxylate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102044", "l": "3-chlorobenzoate-4,5-oxygenase activity", "d": ["Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor = 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73723", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate = (2R,3S,11S)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64133", "l": "H2O + N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39688", "l": "(R)-3-hydroxy-(11Z)-octadecenoyl-CoA => (2E,11Z)-octadecadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509827", "l": "ITPA hydrolyses ITP to IMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37110", "l": "H2O + N(7)-methyl-GMP <=> N(7)-methylguanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74336", "l": "O-2-methylbutanoyl-(R)-carnitine(in) => O-2-methylbutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019905", "l": "syntaxin binding", "d": ["Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106331", "l": "sialate 4-O-acetylesterase activity", "d": ["Catalysis of the reaction: H2O + N-acetyl-4-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate."], "t": []}, {"i": "RHEA:25564", "l": "H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686524", "l": "PP6-PPP6R3 dephosphorylates TERF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33322", "l": "a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA <=> a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818577", "l": "TASP1 cleaves KMT2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20215", "l": "L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein] => L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57687", "l": "4-hydroxyestrone + NH4(+) + O2 <=> 2 H(+) + 2 H2O + pyridinestrone carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047395", "l": "glycerophosphoinositol glycerophosphodiesterase activity", "d": ["Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = sn-glycerol 3-phosphate + myo-inositol + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11055", "l": "4-aminobenzoate + 2 H(+) + NADH + O2 <=> 4-aminophenol + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71607", "l": "(S)-malate(in) + phosphate(out) = (S)-malate(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69371", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) <=> 17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1912357", "l": "ITCH ubiquitinates DTX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53273", "l": "5-dehydro-L-gluconate => keto-D-tagaturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57666", "l": "alpha-nootkatol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-valencene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18306", "l": "acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-4-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9676257", "l": "Formation of the SET1A complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57677", "l": "4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] => 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18405", "l": "H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate", "d": [], "t": []}, {"i": "EC:1.4.1.1", "l": "\"alanine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047428", "l": "arylacetonitrilase activity", "d": ["Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74653", "l": "CDP + H(+) + N-acetyl-D-glucosamine 6-phosphate => CTP + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102013", "l": "ATPase-coupled L-glutamate tranmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-glutamate(out) -> ADP + phosphate + L-glutamate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20543", "l": "2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+) => H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0048531", "l": "beta-1,3-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799418", "l": "TP53 binds the TP53INP1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050351", "l": "trimetaphosphatase activity", "d": ["Catalysis of the reaction: H2O + trimetaphosphate = 2 H+ + triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76864", "l": "benzylamine + H2O + NAD(+) => benzaldehyde + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77676", "l": "a globoside GalGb4Cer (d18:1(4E)) + H2O => an N-acylsphing-4-enine + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806408", "l": "TP53 binds the PMS2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63181", "l": "NADPH + 2 O2 => H(+) + NADP(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61277", "l": "H2O + L-ornithine + O2 => 5-amino-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78585", "l": "3-oxodocosanoyl-CoA + CoA => acetyl-CoA + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11775", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66744", "l": "ATP + H2O + N-acetyl-L-aspartate(in) = ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10142", "l": "H(+) + NADPH + prostaglandin D2 => NADP(+) + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9006850", "l": "IL21 receptor JAK phosphorylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372388", "l": "fructose 1,6-bisphosphate + H2O => fructose 6-phosphate + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75489", "l": "dehydroepiandrosterone 3-sulfate(in) + n H(+)(in) => dehydroepiandrosterone 3-sulfate(out) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038102", "l": "activin receptor antagonist activity", "d": ["Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875523", "l": "MET binds TNS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66597", "l": "O2 + 2 tyramine => 2 dopamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33799", "l": "L-histidinol + NAD(+) = H(+) + L-histidinal + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49868", "l": "(+)-dehydrodiconiferyl acid + a quinone = (+)-dehydrodiconiferyl acid ketone + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65983", "l": "hnu + previtamin D3 <=> tachysterol 3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n13", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140843", "l": "RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 7)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43760", "l": "acetyl-CoA + N-terminal L-seryl-[ribosomal protein bL12] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[ribosomal protein bL12]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30361", "l": "chlorophyllide b + 3 H2O + 2 NADP(+) => chlorophyllide a + 2 H(+) + 2 NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853429", "l": "PHLDA1 binds AURKA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64943", "l": "dGDP + H2O <=> dGMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420117", "l": "VEGFR2 autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868783", "l": "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169399", "l": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76346", "l": "(2S)-2-isopropylmalate(in) + sulfate(out) <=> (2S)-2-isopropylmalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8873794", "l": "PCTP binds PC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46280", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.18", "l": "\"sphingolipid 8-(E)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062131", "l": "3-butenylglucosinolate 2-hydroxylase activity", "d": ["Catalysis of the reaction: gluconapin + a reduced electron acceptor + O2 = xi-progoitrin + an oxidized electron acceptor + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209181", "l": "ARM displaces GRO and binds to PAN which activates transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65130", "l": "1-(10Z-heptadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14920", "l": "3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] <=> 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164943", "l": "Nef mediated activation of the T-cell receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029272", "l": "Release of PLCG from FCGR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77135", "l": "1D-myo-inositol 1,2-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53674", "l": "2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphoethanolamine + A + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013111", "l": "RHOC GAPs stimulate RHOC GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43101", "l": "S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) => 2'-O-methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36780", "l": "2-oxoglutarate + GDP-alpha-D-perosamine => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9821486", "l": "HCFC1 binds SET1A complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35613", "l": "2 H(+) + menadione + 2 superoxide => menadiol + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72271", "l": "formate(out) + oxalate(in) = formate(in) + oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31047", "l": "(S)-2-methyl-3-oxopropanoate + CoA + NAD(+) = CO2 + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52312", "l": "NAD(+) + thromboxane B2 = 11-dehydro-thromboxane B2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32173", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+) => H(+) + NADPH + O2 + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050266", "l": "rosmarinate synthase activity", "d": ["Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49756", "l": "H(+) + O2 + protoviolaceinate = CO2 + H2O + proviolacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835454", "l": "DNAJC3 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60777", "l": "2-oxoglutarate + gibberellin A12 + O2 => CO2 + gibberellin A15 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786118", "l": "IL13 binds IL13RA:TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020282", "l": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140065", "l": "peptide butyryltransferase activity", "d": ["Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide."], "t": []}, {"i": "RHEA:53912", "l": "butanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-912627", "l": "CBL ubiquitinates PI3K (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25665", "l": "(2E)-geranyl diphosphate <=> alpha-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45388", "l": "H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862300", "l": "LYZ binds bacterial peptidoglycan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51190", "l": "peroxynitrite => nitric oxide + superoxide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67868", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] = 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51488", "l": "archaetidylserine + H(+) = archaetidylethanolamine + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66317", "l": "an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O => alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48581", "l": "[pyruvate, water dikinase]-phosphate + H(+) + phosphate => [pyruvate, water dikinase] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852716", "l": "Thrombin, ELANE cleave C5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57748", "l": "2 (S)-methylmalonyl-CoA + 10 H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 3 malonyl-CoA + 5 NADPH = C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14857", "l": "(indol-3-yl)acetate + ATP + L-lysine = ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.20", "l": "\"indoleacetate--lysine synthetase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687465", "l": "MRN complex binds RBBP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "28.689915066710206", "identifiers": [{"i": "GO:0003674", "l": "molecular_function", "d": ["A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.", "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60124", "l": "pre-sodorifen diphosphate = diphosphate + sodorifen", "d": [], "t": []}, {"i": "EC:4.2.3.205", "l": "\"sodorifen synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10598", "l": "ADP + H(+) + O-phospho-L-tyrosyl-[protein] => ATP + L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41829", "l": "(3R)-hydroxyhexanoyl-[ACP] => (2E)-hexenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45142", "l": "CO2 + L-glutamyl-[protein] + O2 + phylloquinol => 2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5444516", "l": "Formation of MSH2:MSH6 Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.354970481220079", "identifiers": [{"i": "GO:0042393", "l": "histone binding", "d": ["Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21204", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester", "d": [], "t": []}, {"i": "EC:2.3.1.43", "l": "\"phosphatidylcholine--sterol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41450", "l": "(4S)-4-hydroxy-L-isoleucine + CO2 + succinate => 2-oxoglutarate + L-isoleucine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5625416", "l": "Anterograde IFT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222020", "l": "NUAK1 phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69068", "l": "RFC dissociates after sliding clamp formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63449", "l": "(2-aminoethyl)phosphonate + CTP => CMP-(2-aminoethyl)phosphonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19775", "l": "D-glyceraldehyde 3-phosphate + H(+) + NADPH => NADP(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111930", "l": "Adenylate cyclase produces cAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162192", "l": "COQ2 ligates all-E-10PrP2 to PHB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134883", "l": "Beta-catenin enhances association of IRF3 with CBP/p300  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41051", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + tetradecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-tetradecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64171", "l": "2-ethyl-L-serine <=> (2S)-2-aminobutanoate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120506", "l": "histone H3K79 dimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl79-[histone H3] + 2 S-adenosyl-L-methionine = 2H+ + N6,N6-methyl-L-lysyl79-[histone H3] + 2 S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38189", "l": "17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72095", "l": "Internal Methylation of mRNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030229", "l": "very-low-density lipoprotein particle receptor activity", "d": ["Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60366", "l": "H(+)(in) + myo-inositol(in) => H(+)(out) + myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43577", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102236", "l": "trans-4-hexen-3-one reductase activity", "d": ["Catalysis of the reaction: trans-4-hexen-3-one + NADPH + H+ = hexan-3-one + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674531", "l": "AAMP binds EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13932", "l": "agmatine + H2O <=> putrescine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12805", "l": "(S)-canadine + S-adenosyl-L-methionine = (S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444838", "l": "Relaxin receptor 1 binds relaxin 2 and 3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42667", "l": "alpha-L-arabinopyanose + NADP(+) <=> H(+) + L-arabinono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63295", "l": "N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74011", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2 = [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70898", "l": "N-terminal L-cysteinyl-[protein] + O2 <=> H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071713", "l": "para-aminobenzoyl-glutamate hydrolase activity", "d": ["Catalysis of the reaction: para-aminobenzoyl-glutamate + H2O = para-aminobenzoate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63494", "l": "menadiol + NADP(+) => H(+) + menadione + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2029473", "l": "Branching and elongation of mother and daughter filaments (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48421", "l": "a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GM1 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48115", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12025", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + choline => D-glucose + O-sinapoylcholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36454", "l": "ATP + glycyl-L-glutamate(out) + H2O <=> ADP + glycyl-L-glutamate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15876", "l": "[(1->4)-alpha-D-glucosyl](n) + an NDP-alpha-D-glucose <=> [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851946", "l": "FIRRM binds PLK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937034", "l": "IRAK1 phosphorylates Pellino (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73405", "l": "(2R,3R)-tartrate(out) + sulfate(in) => (2R,3R)-tartrate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19198", "l": "adenosine 5'-phosphosulfate + NH4(+) => adenosine 5'-phosphoramidate + 2 H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28565", "l": "D-alanine + pyridoxal 5'-phosphate <=> pyridoxamine 5'-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411373", "l": "NLK translocates to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66233", "l": "IC-asc-C7-CoA + O2 => H2O2 + IC-asc-DeltaC7-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63366", "l": "(S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-1,3-oxazole-[protein] + H2O2 => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61879", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682769", "l": "LGI2 binds ADAM22,23 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29257", "l": "Ca(2+)(out) + Na(+)(in) => Ca(2+)(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69910", "l": "2 Na(+)(out) + uridine(out) <=> 2 Na(+)(in) + uridine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59659", "l": "D-cellotriose + O2 <=> D-cellotriono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088307", "l": "FOXM1 binds CCNB1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350578", "l": "NQO1 interaction with ODC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65311", "l": "an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37688", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol => 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40622", "l": "H2O + tridodecanoylglycerol <=> 2,3-didodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102710", "l": "D-inositol-3-phosphate glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + 1D-myo-inositol 3-phosphate = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9815510", "l": "MIB2 binds CYLD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48801", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose => a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54597", "l": "2-oxoglutarate + hexadecanoyl-CoA + O2 => 2-hydroxyhexadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72237", "l": "2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in) => 2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37384", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34700", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-isocomene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14986", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749590", "l": "ASA- acetylates ALB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306876", "l": "NLRP3 activation by small molecules (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578965", "l": "TNRC6A binds AGO2:miRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050502", "l": "cis-zeatin O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31927", "l": "3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.109", "l": "\"3-hydroxyindolin-2-one monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676599", "l": "sBAFF trimer binds BAFFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805061", "l": "CK2 binds FACT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40935", "l": "a 1-acylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0010279", "l": "indole-3-acetic acid amido synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetic acid + an amino acid = an indole-3-acetic acid amide conjugate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867097", "l": "CD99 binds CD99L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69107", "l": "2-oxo-3-sulfanylpropanoate + L-kynurenine <=> H2O + kynurenate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964580", "l": "The complex of HDAC1, RBL1 and E2F4 or HDAC1, RBL2, E2F4 or E2F5 binds CCNA2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5140741", "l": "WNT5A binds FZD and ROR receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13220", "l": "H2O + NAD(+) + succinate semialdehyde <=> 2 H(+) + NADH + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240782", "l": "E2F1/2/3 stimulates EED transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045294", "l": "alpha-catenin binding", "d": ["Binding to catenin complex alpha subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38002", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine <=> H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55259", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8863727", "l": "STON2 is neddylated (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54968", "l": "hexadecanoyl phosphate + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49045", "l": "H(+) + NADH + O2 + protoasukamycin => 4-hydroxyprotoasukamycin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9845538", "l": "ST3GAL2,3 transfer Neu5Ac to gangliosides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29930", "l": "(R)-pantothenate(in) + Na(+)(in) <=> (R)-pantothenate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001406", "l": "glycerophosphodiester transmembrane transporter activity", "d": ["Enables the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737780", "l": "MTTP binds lomitapide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205289", "l": "Autophosphorylation of KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183036", "l": "Ubiquitination of stimulated EGFR (CBL:GRB2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641229", "l": "TLE oligomerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008029", "l": "pentraxin receptor activity", "d": ["Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9842665", "l": "Active LTK binds GRB2:TNK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69063", "l": "N(delta)-hydroxy-N(omega)-methyl-L-arginine + NADH + O2 <=> H2O + N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69680", "l": "apigenin 7-O-beta-D-glucoside + H2O => apigenin + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205205", "l": "Interaction of Src family kinases with p-KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.-", "l": "\"Endoribonucleases producing other than 5'-phosphomonoesters\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27914", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754745", "l": "IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77503", "l": "3-phenylpropanal + hydrogen cyanide = (2S)-2-hydroxy-4-phenylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417896", "l": "P2Y6 receptor can bind to UDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15947", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] => aldehydo-D-glucose 6-phosphate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9860292", "l": "Activated IKBKB phosphorylates IRF5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18014", "l": "H2O + N(5)-ethyl-L-glutamine => ethylamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63143", "l": "H2O + N-tetracosanoyl-taurine <=> taurine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19528", "l": "(2E,6E)-farnesyl diphosphate <=> (1S,8aR)-delta-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158982", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429767", "l": "Passive I- efflux mediated by SLC5A8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22132", "l": "ATP + D-maltose(out) + H2O = ADP + D-maltose(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.5.2.1", "l": "\"ABC-type maltose transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22794", "l": "nocardicin A => isonocardicin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694421", "l": "PP6 dephosphorylates SEC24 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12597", "l": "acetyl-CoA + phosphinothricin = CoA + H(+) + N-acetylphosphinothricin", "d": [], "t": []}, {"i": "EC:2.3.1.183", "l": "\"phosphinothricin acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444773", "l": "EGF-TM7 receptors bind chondroitin sulphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120136", "l": "dUMP kinase activity", "d": ["Catalysis of the reaction: ATP + dUMP = ADP + dUDP."], "t": []}, {"i": "RHEA:30655", "l": "ATP + dUMP = ADP + dUDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74090", "l": "an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP <=> ADP + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636008", "l": "NEIL3 resolves abasic site-induced ICLs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44974", "l": "CoA + O-hexanoyl-(R)-carnitine => (R)-carnitine + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047031", "l": "diethyl 2-methyl-3-oxosuccinate reductase activity", "d": ["Catalysis of the reaction: diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP+ = diethyl 2-methyl-3-oxosuccinate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031433", "l": "telethonin binding", "d": ["Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432513", "l": "CLK is phosphorylated by DCO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209357", "l": "N-HH is palmitoylated by RASP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45398", "l": "(9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68710", "l": "diphosphate + linalool => (2E)-geranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45254", "l": "tetradecanoate(in) => tetradecanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964531", "l": "TOP2A gene gene expression is repressed by the DREAM complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16497", "l": "adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.181", "l": "\"23S rRNA (adenine(1618)-N(6))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140765", "l": "NAD-dependent histone H3K56 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 56) + H2O = histone H3 L-lysine (position 56) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 56 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65269", "l": "3-hydroxypentacecilide A + H(+) + NADPH + O2 => chrodrimanin F + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683593", "l": "ATG7:ATG3:LC3 dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993802", "l": "HLCS biotinylates PC:Mn2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21686", "l": "beta-alanine + H(+) + NADH + pyruvate => (R)-beta-alanopine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19028", "l": "H2O + L-aspartate + O2 <=> H2O2 + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22507", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69311", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate <=> phenylacetonitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67782", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174224", "l": "Dissociation of Cdc20 from APC/C complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26004", "l": "D-xylulose 5-phosphate + H(+) + NADH => D-arabinitol 1-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047601", "l": "acetate kinase (diphosphate) activity", "d": ["Catalysis of the reaction: acetate + diphosphate = acetyl phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47620", "l": "2-ethylhexyl sulfate + 2-oxoglutarate + O2 = 2-ethylhexanal + CO2 + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73443", "l": "2-oxoglutarate + gardenin B + O2 = CO2 + formaldehyde + H(+) + nevadensin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77622", "l": "2 a 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) <=> a 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033788", "l": "leucoanthocyanidin reductase activity", "d": ["Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202248", "l": "Phosphorylation of PLC-gamma1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799246", "l": "CHEK1 phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78880", "l": "a short-chain (3R)-hydroxy fatty acyl-CoA + NAD(+) => a short-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44300", "l": "2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA = 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028724", "l": "AMOT proteins bind YAP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3782655", "l": "HDAC10 deacetylates histone (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41121", "l": "1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5658438", "l": "SPRED dimer binds NF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678843", "l": "ISGylation of protein translation regulator 4EHP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48760", "l": "L-threitol + NAD(+) = H(+) + L-erythrulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16724", "l": "5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950766", "l": "IL27RA dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0016724", "l": "oxidoreductase activity, acting on metal ions, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor."], "t": []}, {"i": "EC:1.16.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036423", "l": "hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity", "d": ["Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48942", "l": "2 an L-alpha-amino acid => an L-aminoacyl-L-amino acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24478", "l": "H(+) + maleamate => H2O + maleimide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807134", "l": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67785", "l": "2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5666001", "l": "Profilin:G-actin binds MKL1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851110", "l": "NTPDase3 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57949", "l": "2-hydroxytoluene + H(+) + NADH + O2 => 3-methylcatechol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614591", "l": "Excess cysteine yields lanthionine and H2S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9854415", "l": "ACAT1 tetramer acetylates IDH2 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26184", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H2O = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374665", "l": "DCC interaction with SIAH1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38014", "l": "chlorophyll a + H2O <=> chlorophyllide a + H(+) + phytol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110311", "l": "POLZ extends translesion synthesis (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71997", "l": "diphosphate + preaspterpenacid acid I => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11976", "l": "anhydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrotetracycline + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.38", "l": "\"anhydrotetracycline 6-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8878056", "l": "RUNX1:CBFB binds EP300 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016802", "l": "trialkylsulfonium hydrolase activity", "d": ["Catalysis of the hydrolysis of a thioether bond, -S-."], "t": []}, {"i": "EC:3.3.1.-", "l": "\"Thioether and trialkylsulfonium hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9661425", "l": "BIL:ALB dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62994", "l": "NH4(+) + tetradecanoate => H2O + tetradecamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004106", "l": "chorismate mutase activity", "d": ["Catalysis of the reaction: chorismate = prephenate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.47181484816187", "identifiers": [{"i": "GO:0008375", "l": "acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26206", "l": "4-nitrophenol + H(+) + NADPH + O2 => 4-nitrocatechol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56299", "l": "2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein] <=> pyruvate + S-sulfanyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814833", "l": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102655", "l": "1-18:1-2-trans-16:1-phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-994038", "l": "IRF2 binds the promoters of Interferon alpha and beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4341073", "l": "PIAS3 SUMOylates PGR with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51453", "l": "O2 + reduced [NADPH--hemoprotein reductase] + ursodeoxycholate => beta-muricholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72206", "l": "2 chloride(out) + hydrogencarbonate(in) <=> 2 chloride(in) + hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047268", "l": "galactinol-raffinose galactosyltransferase activity", "d": ["Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6794346", "l": "NRXNs bind NLGNs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49810", "l": "a quinol + butanal => a quinone + butan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36809", "l": "3-oxo-triacontanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + octacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.87", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250486", "l": "Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3159253", "l": "MMAB adenosylates cob(I)alamin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0004737", "l": "pyruvate decarboxylase activity", "d": ["Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72613", "l": "H(+)(in) + L-alanyl-L-lysine(in) => H(+)(out) + L-alanyl-L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49718", "l": "3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+) => 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55473", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9005980", "l": "IL21 binds IL21R:JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16275", "l": "a sphingomyelin + CMP + H(+) => an N-acylsphing-4-enine + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34277", "l": "3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine => 2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097161", "l": "DH domain binding", "d": ["Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9861616", "l": "DLD dimer dehydrogenates dihydrolipoyl (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755600", "l": "Defective DOLK does not phosphorylate DCHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19536", "l": "2 H(+) + 2 H2O + N(2)-succinyl-L-arginine <=> CO2 + N(2)-succinyl-L-ornithine + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32028", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-cuprenene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52965", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate => H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78367", "l": "H2O + N(tau)-methylhistamine + O2 = 1-methylimidazole-4-acetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1974676", "l": "Beta defensin 103 activates TLR1:TLR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55472", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = 9beta-pimara-7,15-diene-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.68", "l": "\"syn-pimaradiene 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622415", "l": "RIP2 binds NEMO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0016671", "l": "oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide."], "t": []}, {"i": "EC:1.8.4.-", "l": "\"With a disulfide as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433395", "l": "Dimerization of sSCF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5688294", "l": "SIRT5 deacetylates Cytochrome C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75441", "l": "14-demethyleburicol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => eburicol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27422", "l": "(2E,6E)-farnesyl diphosphate => (3E,6E)-alpha-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030774", "l": "anthranilate N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047234", "l": "raffinose-raffinose alpha-galactotransferase activity", "d": ["Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021951", "l": "OPRK1 gene expression is stimulated by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48064", "l": "a ganglioside GD1b (d18:1(4E)) + H2O = a ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38240", "l": "(9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA => 1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202203", "l": "Recruitment of PI3K to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76494", "l": "POR reduces CYP450:Fe3+ to CYP450:Fe2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18484", "l": "cyclohexylsulfamate + H2O <=> cyclohexylamine + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56200", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose = H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634228", "l": "TRAF1 is cleaved by caspases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65447", "l": "butanoyl-CoA + hexan-1-ol <=> CoA + hexyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41992", "l": "17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43356", "l": "cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl (9Z,12Z)-octadecadienoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74450", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66674", "l": "5,7-dihydroxy-4-methylphthalide + H2O => 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193997", "l": "CYP11B1 oxidises 11DCORT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19599", "l": "L-citrulline + NH4(+) => H2O + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15841", "l": "D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2162187", "l": "COQ6 hydroxylates DHB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35719", "l": "(3S)-versiconol acetate + H2O = (S)-versiconol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67175", "l": "O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] <=> formate + 2 H(+) + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606561", "l": "MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17399", "l": "a 3-oxoacyl-[ACP] + H(+) + NADPH => a (3R)-hydroxyacyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18402", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] => (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9604308", "l": "NICD4 traffics to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23485", "l": "A + D-cellobiose => AH2 + D-cellobiono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53243", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> cholesta-5,7-dien-3beta,25-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27638", "l": "phosphate + xanthosine = alpha-D-ribose 1-phosphate + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9676264", "l": "Formation of the SET1B complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867041", "l": "EGFR phosphorylates EPS15 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877192", "l": "RUNX1 binds FOXP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20514", "l": "2-aryl-2-methylmalonate + H(+) => 2-arylpropionate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25571", "l": "ATP + beta-D-ribosylnicotinate <=> ADP + H(+) + nicotinate beta-D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75245", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-leucyl-[protein] => acetyl-CoA + N-terminal L-leucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848829", "l": "CBL autoubiquitinates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684309", "l": "3CLp cleaves nsp6-11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866851", "l": "CFTR transits to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42509", "l": "6-acetamido-2-oxohexanoate + H2O + NAD(+) => 5-acetamidopentanoate + CO2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22869", "l": "3-chloro-L-alanine + thioglycolate => chloride + H(+) + S-carboxymethyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690669", "l": "CD22 binds itself to form homo-oligomers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11092", "l": "NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48655", "l": "lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41405", "l": "(R)-2-methylpyrrolidine + NADP(+) => 2-methyl-1-pyrroline + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70087", "l": "methanol + o-quinone methide = hydroxyclavatol methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69954", "l": "3-dehydro-6alpha-hydroxyteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydroteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814764", "l": "Plasma membrane resorption (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66511", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75625", "l": "14-oxo-15-hydroxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210294", "l": "Interaction of PECAM-1 and SHP-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40875", "l": "(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) = (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696275", "l": "RND2 binds GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004980", "l": "melanocyte-stimulating hormone receptor activity", "d": ["Combining with melanocyte-stimulating hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36239", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O = 1-O-alkyl-2-acyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65788", "l": "diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40118", "l": "H2O + hexanoyl-CoA <=> CoA + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78174", "l": "demethylgadusol + S-adenosyl-L-methionine <=> gadusol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34617", "l": "H(+) + hydrogencarbonate + methylphosphonate => 2-hydroxyethylphosphonate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14961", "l": "H2O + S-formylglutathione = formate + glutathione + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.12", "l": "\"S-formylglutathione hydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70608", "l": "3'-phosphoadenylyl sulfate + 4-ethylphenol => 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30182", "l": "oxalate + oxidized 2[4Fe-4S]-[ferredoxin] <=> 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12703", "l": "[thioredoxin]-dithiol + a ribonucleoside 5'-triphosphate => [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23259", "l": "adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine <=> adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10102", "l": "a fatty acid + a sterol + H(+) => a sterol ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470010", "l": "Dimerization of STATs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70592", "l": "PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374899", "l": "Release of noradrenaline  at the synapse (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51406", "l": "5-guanidino-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-arginine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77427", "l": "benzaldehyde + hydrogen cyanide = (S)-mandelonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43462", "l": "4-hydroxy-6-undecylpyran-2-one + 2 CO2 + 3 CoA => dodecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72692", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) => 17beta-estradiol 17-O-(beta-D-glucuronate)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48275", "l": "2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.29", "l": "\"glycerate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696605", "l": "USP12, USP26 deubiquitinate AR (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52992", "l": "[deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + [eIF5A protein]-L-lysine = [deoxyhypusine synthase]-L-lysine + [eIF5A protein]-N-(4-aminobutylidene)-L-lysine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41996", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = a globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62262", "l": "2 hydrogencarbonate(in) + Mn(2+)(in) => 2 hydrogencarbonate(out) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66551", "l": "3'-phosphoadenylyl sulfate + 4-nitrophenol <=> 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54253", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.89", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37909", "l": "(8E,10S)-10-hydroperoxy-octadeca-8-enoate => (9Z)-octadecenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15954", "l": "agmatine + ATP => ADP + 2 H(+) + N(4)-phosphoagmatine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42898", "l": "H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine => L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34538", "l": "H(+) + hexadecanoyl-CoA + L-alanine <=> 1-deoxy-3-dehydrosphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197770", "l": "STAB1 (FEEL-1) binds ligands (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047811", "l": "D-alanine gamma-glutamyltransferase activity", "d": ["Catalysis of the reaction: D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374664", "l": "Phosphorylation and activation of Ezrin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13080", "l": "a D-hexose + an acyl phosphate <=> a carboxylate + D-hexose phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52273", "l": "(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine => gramine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51878", "l": "desmethylxanthohumol + diphosphate => 2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76888", "l": "5-hydroxypentan-2-amine + H2O + NAD(+) => 5-hydroxypentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57743", "l": "a 2,3-saturated meromycolyl-[ACP] + NAD(+) <=> a trans-Delta(2)-meromycolyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904593", "l": "prostaglandin binding", "d": ["Binding to prostaglandin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9770142", "l": "Formation of the Spliceosomal B complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047995", "l": "hydroxyphenylpyruvate reductase activity", "d": ["Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16605", "l": "dodecanoyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.2", "l": "\"decylcitrate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41549", "l": "8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928594", "l": "SFKs phosphorylate GIT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29575", "l": "L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14730", "l": "beta-D-fructose 1,6-bisphosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2530453", "l": "Vitronectin (VTN) binds to C5b:C6:C7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250217", "l": "ARL2:GTP binds ARL2BP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69731", "l": "CoA + phenylacetyl-AMP = AMP + H(+) + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41948", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.2.1.103", "l": "\"[amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40124", "l": "an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46623", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol <=> (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39671", "l": "(9Z)-hexadecenoyl-CoA + AH2 + O2 = (9Z,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37824", "l": "(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 => 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619756", "l": "NR1H2 binds ABCA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218832", "l": "CDC42:GTP binds PAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55426", "l": "(3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031740", "l": "type A cholecystokinin receptor binding", "d": ["Binding to a type A cholecystokinin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57881", "l": "3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose => 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71718", "l": "H(+)(out) + L-leucyl-L-leucine(out) <=> H(+)(in) + L-leucyl-L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52279", "l": "(6S)-5,6,7,8-tetrahydrofolate + vanillate <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.368900840266221", "identifiers": [{"i": "GO:0180030", "l": "inositol phosphate kinase activity", "d": ["Catalysis of the reaction: inositol phosphate + ATP = inositol phosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77231", "l": "cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate) + H2O = (S)-2-hydroxypropylphosphonate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59469", "l": "an S-substituted glutathione + H2O => an S-substituted L-cysteinylglycine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60684", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) = (11R)-dihydroartemisinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032781", "l": "WWTR1 (TAZ) binds TEAD (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57232", "l": "GDP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65753", "l": "2-oxoglutarate + L-glutamate + O2 => (3R)-3-hydroxy-L-glutamate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25215", "l": "2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP => H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624778", "l": "SFTPD 12mer translocates from ER membrane to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654571", "l": "Activated FGFR1 binds FRS3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51214", "l": "12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH => (5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27652", "l": "GDP + H(+) + UMP => GTP + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61256", "l": "H2O + L-cysteine + O2 = 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69005", "l": "Cdc6 protein is phosphorylated by CDK (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30946", "l": "FAD + H(+) + octanoyl-CoA <=> (2E)-octenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66610", "l": "GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate) => (tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6793591", "l": "LIAS synthesizes lipoyl-GCSH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25503", "l": "(2E)-geranyl diphosphate <=> diphosphate + terpinolene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10434", "l": "acetate + CO2 + NH4(+) + succinate semialdehyde => 2-(acetamidomethylene)succinate + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959462", "l": "SAMD8 transfers phosphatidyl from PE onto C16DH CER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210285", "l": "Trans-homophilic interaction of PECAM-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16518", "l": "(R)-1-aminopropan-2-ol + NAD(+) => aminoacetone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24235", "l": "2-dehydro-3-deoxy-D-gluconate + NAD(+) <=> 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9709406", "l": "CO binds to Cytochrome c oxidase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1679589", "l": "Engulfed CpG DNA binds to endosomal full-length TLR9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299338", "l": "Activation of TRESK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001786", "l": "phosphatidylserine binding", "d": ["Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626817", "l": "PKC phosphorylates NCF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66624", "l": "cholest-4-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (25S)-3-oxocholest-4-en-26-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35362", "l": "3-hydroxyisoheptadecanoyl-CoA <=> (2E)-15-methylhexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028598", "l": "Phosphorylation of YAP by LATS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26554", "l": "angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine", "d": [], "t": []}, {"i": "EC:3.4.17.23", "l": "\"angiotensin-converting enzyme 2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78326", "l": "glyoxylate + L-glutamine <=> 2-oxoglutaramate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62455", "l": "ATP + holo-[peptidyl-carrier protein] + L-glutamate <=> AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28055", "l": "2-oxobutanoate + CoA => formate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009030", "l": "thiamine-phosphate kinase activity", "d": ["Catalysis of the reaction: ATP + thiamine phosphate = ADP + H+ + thiamine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63459", "l": "(2E,6E,10E)-geranylgeraniol + CTP <=> (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004144", "l": "diacylglycerol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17804", "l": "acetyl-CoA + L-phenylalanine <=> CoA + H(+) + N-acetyl-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55439", "l": "ferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055104", "l": "ligase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a ligase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70121", "l": "28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71610", "l": "(S)-malate(in) + phosphate(out) <=> (S)-malate(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32910", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52190", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O => 1-aci-nitro-2-(1H-indol-3-yl)ethane + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871227", "l": "RET binds GFRA4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16801", "l": "3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein]", "d": [], "t": []}, {"i": "EC:2.8.2.20", "l": "\"protein-tyrosine sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56645", "l": "a uridine in mRNA => a pseudouridine in mRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866105", "l": "CCPs deglutamylate tubulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67986", "l": "N-acetyl-D-leucine => N-acetyl-L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43407", "l": "N-(2-hydroxy-hexanoyl)-sphinganine + UDP-alpha-D-galactose <=> H(+) + N-(2-hydroxyhexanoyl)-beta-D-galactosylsphinganine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003925", "l": "G protein activity", "d": ["A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-741449", "l": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64304", "l": "1-phenylpropylamine + pyruvate = 1-phenylpropan-1-one + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9825759", "l": "MAPK-dependent phosphorylation of KARS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30980", "l": "A + all-trans-lycopene => AH2 + all-trans-3,4-didehydrolycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042950", "l": "salicin transmembrane transporter activity", "d": ["Enables the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265177", "l": "Exocyst complex formation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74758", "l": "kaempferide + S-adenosyl-L-methionine <=> 3,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62526", "l": "H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine => cytidine(839) in 12S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018659", "l": "4-hydroxybenzoate 3-monooxygenase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042071", "l": "leucokinin receptor activity", "d": ["Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802914", "l": "RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55453", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49009", "l": "aurachin C + H(+) + NADPH + O2 => aurachin C epoxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75834", "l": "5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] <=> 5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842656", "l": "ALK binds ALKAL ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51118", "l": "H(+) + N(2)-methylguanosine(6) in tRNA + S-adenosyl-L-homocysteine => guanosine(6) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55810", "l": "a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O => a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1614544", "l": "Sulfite is oxidized to sulfate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63718", "l": "losartan-1-N-beta-D-glucuronide + UDP => losartan + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31818", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-(E)-beta-caryophyllene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33079", "l": "6-amino-6-deoxyfutalosine + H2O = adenine + dehypoxanthine futalosine", "d": [], "t": []}, {"i": "EC:3.2.2.30", "l": "\"aminodeoxyfutalosine nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64979", "l": "8-oxo-dGTP + 2 H2O <=> 8-oxo-dGMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043831", "l": "thiosulfate dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: 6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54076", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + stellata-2,6,19-triene", "d": [], "t": []}, {"i": "EC:4.2.3.178", "l": "\"stellata-2,6,19-triene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40732", "l": "(20S)-ginsenoside Rg3 + 2 H2O => (20S)-protopanaxadiol + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63771", "l": "2 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50342", "l": "1alpha-hydroxytestosterone + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37038", "l": "H2O + L-2-aminopentanoate + NAD(+) <=> 2-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202500", "l": "Activation of IKK complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-378956", "l": "Luteinizing hormone is a heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202721", "l": "JAM2 binds JAM3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21311", "l": "(S)-2,3-epoxysqualene <=> cycloartenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59789", "l": "H2O + NAD(+) + pseudopaline => (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22709", "l": "H2O + S-acylglutathione => a carboxylate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481044", "l": "Surface deployment of platelet alpha granule membrane components (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48618", "l": "glycine + leukotriene E4 => H2O + leukotriene D4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57214", "l": "N(2)-(1-hydroxy-2-oxopropyl)-dGTP => dGTP + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57999", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rh2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052731", "l": "phosphocholine phosphatase activity", "d": ["Catalysis of the reaction: choline phosphate + H2O = choline + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53962", "l": "4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H(+) + H2O => 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39558", "l": "3-oxo-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37777", "l": "1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34343", "l": "(20R,22R)-20,22-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 4-methylpentanal + 2 H2O + 2 oxidized [adrenodoxin] + pregnenolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42017", "l": "cortisone + NAD(+) => 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.-", "l": "\"Phosphotransferases with regeneration of donors, apparently catalyzing intramolecular transfers\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9853389", "l": "FIGNL1 binds RAD51 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784959", "l": "BPHL hydrolyses VACV to ACV (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664879", "l": "ATM:PEX5 binds ATM (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43160", "l": "adenosine(37) in tRNA1(Val) + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(37) in tRNA1(Val) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.223", "l": "\"tRNA1(Val) (adenine(37)-N(6))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047938", "l": "glucose-6-phosphate 1-epimerase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28774", "l": "(2E)-hexadecenoyl-CoA <=> (9Z)-hexadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64951", "l": "dCTP + H2O <=> dCDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38495", "l": "a triacylglycerol + H2O = a 1,3-diacylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57878", "l": "pseudouridine(54) in tRNA => uridine(54) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65215", "l": "(2E)-dodecenoyl-CoA + H2O <=> (2E)-dodecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72540", "l": "3,4-dihydroxybenzaldehyde + H2O + NADP(+) => 3,4-dihydroxybenzoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14108", "l": "L-proline + NAD(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017398", "l": "NOTCH3 coactivator complex binds HEYL gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917811", "l": "STEAP3,STEAP4 reduce Fe3+ to Fe2+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15045", "l": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77054", "l": "3,5-dimethylcyclohexanamine + H2O + NADP(+) <=> 3,5-dimethylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9749197", "l": "ORC1 binds to H4K20me2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3788745", "l": "EHMT1:EHMT2 methylates IL8 promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19433", "l": "ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.12", "l": "\"gluconokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69336", "l": "(E)-alk-1-en-1-SO-peroxol = (Z)-alkanethial oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-434989", "l": "SEMA7A binds to PLXNC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373074", "l": "Receptor CCR9  binds CCL25 ligand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-606287", "l": "RSF complex binds the centromere (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17633", "l": "a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate", "d": [], "t": []}, {"i": "EC:3.2.1.31", "l": "\"beta-glucuronidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45767", "l": "H2O + L-aspartate 4-semialdehyde + NAD(+) <=> 2 H(+) + L-aspartate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27900", "l": "adenosine + phosphate => 3'-AMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848335", "l": "IL37 binds  IL18R1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65550", "l": "alpha-Fuc-(1->2)-beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-Glc + an N-acyl-sphingoid base => a ganglioside Fuc-GM1 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050393", "l": "vinylacetyl-CoA delta-isomerase activity", "d": ["Catalysis of the reaction: vinylacetyl-CoA = (2E)-butenoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372505", "l": "Acetylcholine synaptic vesicle docking and priming (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052924", "l": "all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734730", "l": "ORC1 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5620975", "l": "MLKL binds PIPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45390", "l": "(9Z)-octadecenoate + H(+) + N-octadecanoyl-sn-glycero-3-phospho-ethanolamine => H2O + N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23430", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654533", "l": "KRAS4B recycles to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798528", "l": "S100A8:S100A9 binds Mn2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38820", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75862", "l": "Fall Back to Closed Pre-initiation Complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37328", "l": "ATP + H2O + L-methionyl-L-alanine(out) => ADP + H(+) + L-methionyl-L-alanine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28130", "l": "baicalin + H2O = baicalein + D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629369", "l": "NEIL3 recognizes and binds to thymine glycol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373129", "l": "fumarate + FADH2 <=> succinate + FAD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36588", "l": "an aldopyranose + NADP(+) => aldono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34102", "l": "carboxynorspermidine + H(+) <=> CO2 + norspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112385", "l": "Addition of nucleotides leads to transcript elongation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450325", "l": "c-FOS activation by phospho ERK1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0032576", "l": "O-linoleoyltransferase activity", "d": ["Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32011", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-T-muurolol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.98", "l": "\"(+)-T-muurolol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392263", "l": "AVP(20-28) binds AVPR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014296", "l": "RAC2 GEFs activate RAC2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102429", "l": "genistein-3-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: genistin + UDP-alpha-D-glucose = genistin 7-gentiobioside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-443439", "l": "c-Src binds Raf1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943279", "l": "GGT dimers hydrolyse GSH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943279", "l": "GGT dimers hydrolyse GSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40878", "l": "(9Z,12Z)-octadecadienoyl-CoA + FAD + H(+) <=> (2E,9Z,12Z)-octadecatrienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37169", "l": "(2E,6E)-farnesal + H(+) + NADH => (2E,6E)-farnesol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10541", "l": "7,8-dihydroneopterin => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647632", "l": "CASP3 cleaves GSDME (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52471", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66447", "l": "hexan-3-one + NADP(+) <=> (E)-4-hexen-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10947", "l": "H2O + psi-UMP <=> phosphate + pseudouridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44231", "l": "9-decenoate + ATP + CoA <=> 9-decenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66279", "l": "tigogenin + UDP-alpha-D-glucose <=> H(+) + tigogenin 3-O-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27409", "l": "3 a menaquinone + protoporphyrinogen IX = 3 a menaquinol + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174967", "l": "NAT2 acetylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62243", "l": "a thymidine(6-4)cytidine in DNA <=> a thymine-cytidine dinucleotide in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-349455", "l": "Phosphorylation of MDM4 by ATM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72052", "l": "butanoate(out) + estrone 3-sulfate(in) => butanoate(in) + estrone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35705", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+) => 1'-hydroxyversicolorone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0071913", "l": "citrate secondary active transmembrane transporter activity", "d": ["Enables the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015192", "l": "L-phenylalanine transmembrane transporter activity", "d": ["Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977371", "l": "Factor I inactivates Factor H-boundC3b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.71648590403835", "identifiers": [{"i": "GO:0019786", "l": "protein-phosphatidylethanolamide deconjugating activity", "d": ["Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034521", "l": "1-naphthoic acid dioxygenase activity", "d": ["Catalysis of the reaction: 1-naphthoic acid + NADH + O2 + H+ = cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201316", "l": "Activated TLR2/4 interacts with MAL (TIRAP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936729", "l": "sulfate is activated to APS (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75374", "l": "guanosine(in) <=> guanosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44936", "l": "(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA = (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216061", "l": "SPP1 (osteopontin) binds integrin alpha8beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817400", "l": "CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30979", "l": "A + all-trans-lycopene = AH2 + all-trans-3,4-didehydrolycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54111", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + guaia-4,6-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45869", "l": "9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78346", "l": "5'-pGpA(2'-5') + H2O <=> 5'-GpA(2'-5') + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31343", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.85", "l": "\"glucosyl-3-phosphoglycerate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71181", "l": "FAH cleaves 4FAA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060001", "l": "minus-end directed microfilament motor activity", "d": ["A motor activity that generates movement along a microfilament towards the minus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33812", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine => 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047546", "l": "2-hydroxypyridine 5-monooxygenase activity", "d": ["Catalysis of the reaction: 2-hydroxypyridine + AH(2) + O2 = 2,5-dihydroxypyridine + A + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134962", "l": "DHX36 binds DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20665", "l": "1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.263", "l": "\"1,5-anhydro-D-fructose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28241", "l": "calycosin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77721", "l": "a neolactoside IV(4)-beta-GalNAc-IV(3)-alpha-NeuGc-nLc4Cer(d18:1(4E)) + H(+) + UDP => a neolactoside IV(3)-alpha-NeuGc-nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75410", "l": "2-dehydro-D-glucose <=> cortalcerone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031735", "l": "CCR10 chemokine receptor binding", "d": ["Binding to a CCR10 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52881", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate => 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062081", "l": "activating MHC class Ib receptor activity", "d": ["Combining with a MHC class Ib protein complex to mediate signaling that activates a lymphocyte."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60473", "l": "(6S)-5-formyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) => (6S)-5-formyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652137", "l": "Damaged dsDNA becomes damaged DNA template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46065", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12616", "l": "2 glutathione + L-cystine <=> glutathione disulfide + 2 L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41139", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18313", "l": "(R)-mandelonitrile = benzaldehyde + hydrogen cyanide", "d": [], "t": []}, {"i": "EC:4.1.2.10", "l": "\"(R)-mandelonitrile lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0047865", "l": "dimethylglycine dehydrogenase activity", "d": ["Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953037", "l": "E2F8 forms homodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75752", "l": "(9Z)-octadecenoate + H2O => 10-hydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637770", "l": "Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38734", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050048", "l": "L-leucine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41570", "l": "aclacinomycin S + dTDP + H(+) => aclacinomycin T + dTDP-2-deoxy-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40851", "l": "FAD + H(+) + pentadecanoyl-CoA = (2E)-pentadecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26062", "l": "Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine <=> methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47998", "l": "H2O2 + NAD(+) => 1,6-dihydro-beta-NAD + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77465", "l": "(2S)-2-(furan-3-yl)-2-hydroxyacetonitrile => furan-3-carbaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65141", "l": "AH2 + O2 + protoaustinoid A => A + berkeleyone A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004151", "l": "dihydroorotase activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73551", "l": "GDP(out) + UTP(in) = GDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684806", "l": "Unknown kinase phosphorylates CLEC1B dimer:PDPN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1368889", "l": "Expression of NAMPT (NamPRT, PBEF, Visfatin) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.28", "l": "\"S-methyl-5'-thioadenosine phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56044", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3)", "d": [], "t": []}, {"i": "EC:3.2.1.210", "l": "\"endoplasmic reticulum Man8GlcNAc2 1,2-alpha-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428259", "l": "DEGS1 dehydrogenates dihydroceramide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607023", "l": "factor IXa associates with cell membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30742", "l": "1D-myo-inositol 3-phosphate + H2O <=> myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748983", "l": "TPMT transfers methyl group to 6MP, forming 6MeMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36672", "l": "(17Z)-hexacosenoyl-CoA + sphinganine => CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45252", "l": "tetradecanoate(out) = tetradecanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78706", "l": "4-(hydroxy(methyl)phosphoryl)-2-oxobutanoate + L-glutamate <=> 2-oxoglutarate + L-phosphinothricin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-350598", "l": "Arginine<=>Agmatine+CO2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156930", "l": "GTP-binding activates eEF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625426", "l": "Retrograde IFT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.64", "l": "\"mitochondrial processing peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74934", "l": "2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2 <=> a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29438", "l": "enterobactin(in) + H(+)(out) <=> enterobactin(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638006", "l": "ARL3 hydrolyzes GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58881", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65057", "l": "glycochenodeoxycholate + NADP(+) => 7-oxoglycolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14673", "l": "a polar amino acid(out) + ATP + H2O = a polar amino acid(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416358", "l": "G alpha (q) inhibits PI3K alpha (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950190", "l": "Expression of PAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77077", "l": "Capping complex formation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43975", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> H(+) + hexadecanoate + hexadecanoyl-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50723", "l": "FMNH2 + methanesulfinate + O2 <=> FMN + H(+) + H2O + methanesulfonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65300", "l": "2-oxoglutarate + chrodrimanin C + O2 = CO2 + H2O + succinate + verruculide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13022", "l": "H(+) + NADH + O2 + vanillate => 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36563", "l": "GDP-beta-L-colitose + NADP(+) = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9674095", "l": "PDGFRs bind type II TKI (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45216", "l": "coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein] = Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78563", "l": "(3R)-hydroxytetracosanoyl-CoA + NAD(+) = 3-oxotetracosanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15651", "l": "CO2 + NH4(+) => carbamate + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322431", "l": "XIAP binds TLE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38545", "l": "(2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein] => H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10087", "l": "3,4-dihydroxybenzoate + O2 <=> 3-carboxy-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36557", "l": "CoA + H(+) + N-eicosanoylsphinganine => eicosanoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66923", "l": "6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate <=> (2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40601", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28681", "l": "H(+) + S-adenosyl-L-homocysteine + ubiquinol-8 => 3-demethylubiquinol-8 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63056", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine = 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67899", "l": "a 3'-end uridylyl-adenosine-RNA <=> a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73525", "l": "TTP(in) + UTP(out) => TTP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-445071", "l": "Reinsertion of L1 into the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9725855", "l": "NR3C2 binds NR3C2 antagonists (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649733", "l": "mature p21 RAS binds GDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12924", "l": "glycine + H(+) + succinyl-CoA <=> 5-aminolevulinate + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47582", "l": "a ganglioside GT2 (d18:1(4E)) + H(+) + UDP => a ganglioside GT3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36812", "l": "acetyl-CoA + GDP-alpha-D-perosamine => CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030941", "l": "chloroplast targeting sequence binding", "d": ["Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53118", "l": "an 11-oxosteroid + H(+) + NADH => an 11beta-hydroxysteroid + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17712", "l": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate <=> 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76666", "l": "H2O + NADP(+) + pentanal <=> 2 H(+) + NADPH + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61158", "l": "CoA + GDP + H(+) => 3'-dephospho-CoA + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48534", "l": "a ganglioside GT1c (d18:1(4E)) + N-acetylneuraminate => a ganglioside GQ1c (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984606", "l": "Kinesin-5 is a homotetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44070", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18803", "l": "(cis-prenyl)(n+1)-diphosphate + diphosphate => (cis-prenyl)n-diphosphate + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70744", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43251", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O <=> 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60609", "l": "1-tetradecanoyl-sn-glycero-3-phosphoethanolamine => 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57454", "l": "H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine => L-glutaminyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29390", "l": "CTP + H2O <=> CDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64825", "l": "1-naphthaleneacetamide + H2O => 1-naphthaleneacetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22805", "l": "(6S,9R)-vomifoliol + NAD(+) => (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047694", "l": "barbiturase activity", "d": ["Catalysis of the reaction: barbiturate + H2O = malonate + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168882", "l": "Association of NP into rafts (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35346", "l": "3-hydroxydocosanoyl-CoA + NADP(+) <=> 3-oxodocosanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48272", "l": "2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37012", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102507", "l": "cyanidin 3-O-glucoside 7-O-glucosyltransferase (hydroxybenzoly-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose = cyanidin 3,7-di-O-beta-D-glucoside betaine + 4-hydroxybenzoic acid + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40556", "l": "dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 => dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19773", "l": "NADP(+) + sn-glycerol 3-phosphate = D-glyceraldehyde 3-phosphate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.177", "l": "\"glycerol-3-phosphate 1-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62259", "l": "Cd(2+)(out) + 2 hydrogencarbonate(out) <=> Cd(2+)(in) + 2 hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48354", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047711", "l": "blasticidin-S deaminase activity", "d": ["Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0016884", "l": "carbon-nitrogen ligase activity, with glutamine as amido-N-donor", "d": ["Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen."], "t": []}, {"i": "EC:6.3.5.-", "l": "\"Carbon--nitrogen ligases with glutamine as amido-N-donor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836275", "l": "TFAP2A binds TFAP2B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8957241", "l": "TP73 tetramer translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24028", "l": "2-oxoglutarate + 4-(trimethylamino)butanoate + O2 = carnitine + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.1", "l": "\"gamma-butyrobetaine dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213200", "l": "Release of endostatin-like peptides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27806", "l": "acetoacetate + acetyl-CoA = acetate + acetoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43306", "l": "1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + beta-D-Gal-(1<->1')-Cer", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66067", "l": "2-oxohexanoate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102816", "l": "UDP-D-glucose:delphinidin 3-O-glucosyl-5-O-caffeoylglucoside -O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-glucosyl-5-O-caffeoylglucoside = H+ + delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18295", "l": "AMP + diphosphate + oxalyl-CoA => ATP + CoA + oxalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848250", "l": "ACBD6 binds LCFA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875183", "l": "CBL monoubiquitinates activated MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24217", "l": "(2E,6E)-farnesal + H2O + NAD(+) => (2E,6E)-farnesoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33601", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139941", "l": "Binding of IP3 to IP3 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70997", "l": "SUCLG1/A2 cleaves succinyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75928", "l": "cyclohexylamine + H2O + NAD(+) => cyclohexanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50104", "l": "taurine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-183072", "l": "EGFR non-clathrin mediated endocytosis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17849", "l": "(3R)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.55", "l": "\"3-hydroxybutyryl-CoA dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13958", "l": "4 H2O + O2 + 4 sulfur => 6 H(+) + 2 hydrogen sulfide + 2 sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031823", "l": "type 1D serotonin receptor binding", "d": ["Binding to a type 1D serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26209", "l": "L-allo-threonine = acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051431", "l": "corticotropin-releasing hormone receptor 2 binding", "d": ["Binding to a corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817435", "l": "DUX4 binds the KDM4E gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.116", "l": "\"3-hydroxypropionyl-CoA dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44195", "l": "2-methylhexadecanoate + ATP + CoA <=> 2-methylhexadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103096", "l": "CYP79F1 dihomomethionine monooxygenase activity", "d": ["Catalysis of the reaction: dihomomethionine + 2 O2 + 2 NADPH + 2 H+ = 5-methylthiopentanaldoxime + 3 H2O + carbon dioxide + 2 NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110311", "l": "POLZ extends translesion synthesis (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57315", "l": "H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine <=> cytidine 5'-diphosphoramidate + H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086079", "l": "gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428749", "l": "Activated TP receptor binds G-proten Gq (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29499", "l": "(2E,6E)-farnesyl diphosphate = (+)-alpha-barbatene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.69", "l": "\"(+)-alpha-barbatene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25124", "l": "(S)-2-amino-6-oxohexanoate <=> H(+) + H2O + L-1-piperideine-6-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67117", "l": "N(6)-methyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(37)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54233", "l": "1,2-dioctanoyl-sn-glycerol + CDP-choline => 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57775", "l": "3-nitrotoluene + NADH + O2 <=> 4-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50026", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine => dodecanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611852", "l": "ADRB3 bind ADR,NAd (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029268", "l": "Phosphorylation and activation of PLCG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193656", "l": "p75NTR interacts with RIP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41605", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine => 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112437", "l": "Formation of NELF complex  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55125", "l": "(2E)-5-methylhexenoyl-[ACP] + H(+) + NADH => 5-methylhexanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.27", "l": "\"cathepsin S\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64676", "l": "3-(methylsulfanyl)propanoyl-CoA + butan-1-ol = butyl 3-(methylsulfanyl)propanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0001046", "l": "core promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061675", "l": "RBL family protein binding", "d": ["Binding to a member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001072", "l": "transcription antitermination factor activity, RNA binding", "d": ["Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050197", "l": "phytanate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H+ + phytanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78143", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = a 1,3-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140337", "l": "diacylglyceride transfer activity", "d": ["Directly binding to diacylglyceride and delivering it either to an acceptor molecule or to a specific location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42015", "l": "cortisol + NAD(+) <=> 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36402", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) <=> H(+) + NADPH + zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5227009", "l": "ABCF1 binds EIF2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201423", "l": "SKI complexes with the Smad complex, suppressing BMP2 signalling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400272", "l": "FBXL3 binds phosphorylated CRY proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69116", "l": "glyoxylate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32134", "l": "(2S)-ethylmalonyl-CoA + H(+) <=> butanoyl-CoA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22486", "l": "GMP + GTP + 2 H(+) => H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17155", "l": "CDP-4-dehydro-6-deoxy-D-glucose + H2O => CDP-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.9", "l": "\"tripeptidyl-peptidase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218847", "l": "PAK2 binds NCK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74768", "l": "S-adenosyl-L-methionine + syringetin => 3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58623", "l": "N-decanoyl-(2S)-hydroxyglycine <=> decanamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606789", "l": "ARSB hydrolyses DS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69900", "l": "2 Na(+)(out) + thymidine(out) => 2 Na(+)(in) + thymidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44656", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046180", "l": "KSPG is secreted from the cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168373", "l": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1900995", "l": "ubiquinone-6 binding", "d": ["Binding to ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69130", "l": "4-methyl-2-oxopentanoate + glycine => glyoxylate + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59276", "l": "L-glutamine = D-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047067", "l": "hydrogen:quinone oxidoreductase activity", "d": ["Catalysis of the reaction: H(2) + menaquinone = reduced menaquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39479", "l": "(2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADPH = (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67155", "l": "L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[NO transferase protein] <=> L-cysteinyl-[NO transferase protein] + S-nitroso-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161673", "l": "PGD2 is dehydrated to 15d-PGD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14426", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27630", "l": "ethylene glycol + NAD(+) = glycolaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27465", "l": "ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.70", "l": "\"D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9690461", "l": "FKBP1A binds tacrolimus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45838", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34481", "l": "15-cis-phytoene + diphosphate => (1R,2R,3R)-prephytoene diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036055", "l": "protein-succinyllysine desuccinylase activity", "d": ["Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD+ = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:47668", "l": "H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22753", "l": "A + H2O + uracil => AH2 + barbiturate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43078", "l": "H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase] => erythrodiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63428", "l": "ATP + H2O + levoglucosan = ADP + D-glucose 6-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.232", "l": "\"levoglucosan kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10905", "l": "[cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A => AH2 + C(3,19),S(21)-[cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209823", "l": "Tyrosine is hydroxylated to dopa (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0034595", "l": "phosphatidylinositol phosphate 5-phosphatase activity", "d": ["Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70845", "l": "L-arginine(out) + L-methionine(in) + Na(+)(in) => L-arginine(in) + L-methionine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15888", "l": "NADP(+) + propane-1,2-diol <=> (S)-lactaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72965", "l": "acetoacetate(in) + 2 Na(+)(in) => acetoacetate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59365", "l": "1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O => 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34192", "l": "(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36095", "l": "S-adenosyl-L-methionine + salicylate = methyl salicylate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.274", "l": "\"salicylate carboxymethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468287", "l": "CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21456", "l": "(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.19.68", "l": "\"(S)-canadine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004032", "l": "aldose reductase (NADPH) activity", "d": ["Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683664", "l": "GSK3 phosphorylates Nucleoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35042", "l": "spermidine(in) <=> spermidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451152", "l": "MAP kinase p38 phosphorylates KSRP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52410", "l": "CO2 + dihydroxyacetone phosphate + NADH => 4-phospho-D-erythronate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16035", "l": "CO2 + gibberellin A19 + H2O + succinate => 2-oxoglutarate + gibberellin A44 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10801", "l": "diphosphate + XMP => 5-phospho-alpha-D-ribose 1-diphosphate + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25296", "l": "acetate + 2 H(+) + NADH => acetaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39926", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036011", "l": "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264865", "l": "Caspase-mediated cleavage of Lamin A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40847", "l": "eicosanoyl-CoA + FAD + H(+) = (2E)-eicosenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58175", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> beta-pinacene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52786", "l": "A + ergothioneine + H2O => 2-sulfenohercynine + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67355", "l": "malonyl-CoA + rhaponticin <=> 6-O-malonyl-rhaponticin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0032553", "l": "ribonucleotide binding", "d": ["Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140771", "l": "ACP-dependent peptidyl-lysine N6-palmitoyltransferase activity", "d": ["Catalysis of the reaction: hexadecanoyl-[ACP] + L-lysyl-[protein] = H+ + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]."], "t": []}, {"i": "RHEA:70615", "l": "hexadecanoyl-[ACP] + L-lysyl-[protein] = H(+) + holo-[ACP] + N(6)-hexadecanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54798", "l": "an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH => a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32607", "l": "(6E)-8-hydroxygeraniol + NADP(+) = (6E)-8-hydroxygeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450466", "l": "AUF1:mRNA complex is destroyed (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53970", "l": "adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP] => apo-[BtrI ACP] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824979", "l": "XPO1 binds p-S69,73 MITF-M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13246", "l": "D-threo-isocitrate => glyoxylate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48072", "l": "a ganglioside GM1 (d18:1(4E)) + H2O = a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70737", "l": "chloride(in) + glycine betaine(in) + 2 Na(+)(in) => chloride(out) + glycine betaine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211391", "l": "Anthrax lef cleaves target cell MAP2K4 (MEK4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110360", "l": "Recruitment of POLB to the AP site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8847977", "l": "FRK phosphorylates PTEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42125", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) => androsterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928619", "l": "PAK1 binds RAC1:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62848", "l": "GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate = GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53717", "l": "H(+) + N-acetyl-alpha-D-muramate 1-phosphate + UDP => phosphate + UDP-N-acetyl-alpha-D-muramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39092", "l": "(2E)-decenedioyl-CoA + H2O => (3S)-hydroxydecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31769", "l": "L-glutamate + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose => 2-oxoglutarate + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60655", "l": "an N-(acyl)-sphingosylphosphocholine <=> an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11188", "l": "3-cyano-L-alanine + 2 H2O = L-aspartate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.5.4", "l": "\"cyanoalanine nitrilase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9705713", "l": "SRD5A2 dehydrogenates TEST to DHTEST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69893", "l": "Na(+)(in) + thymidine(in) => Na(+)(out) + thymidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38904", "l": "a sphingomyelin(in) + ATP + H2O => a sphingomyelin(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83677", "l": "C4 deamination of cytidine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047709", "l": "bis(2-ethylhexyl)phthalate esterase activity", "d": ["Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20816", "l": "3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.230", "l": "\"3alpha-hydroxyglycyrrhetinate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20381", "l": "androsterone + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1982065", "l": "Ligand-independent dimerization of overexpressed FGFR1b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44501", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5221061", "l": "TDG excises 5-carboxylcytosine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53293", "l": "H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin => H(+) + N-carbamoyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33397", "l": "GMP + N(alpha)-acetyl-L-lysine methyl ester => H2O + N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782224", "l": "3' incision by ERCC5 (XPG) in TC-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0000908", "l": "taurine dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + succinate + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39001", "l": "a 1-acyl-sn-glycero-3-phosphate + H(+) + L-serine => a 1-acyl-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202724", "l": "P-selectin binds P-selectin ligand (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11764", "l": "H2O + methylguanidine = methylamine + urea", "d": [], "t": []}, {"i": "EC:3.5.3.16", "l": "\"methylguanidinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.54", "l": "\"calpain-3\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34264", "l": "dimethylallyl diphosphate + fumigaclavine A => diphosphate + fumigaclavine C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48827", "l": "GDP-beta-L-fucose + Lc4Cer <=> a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218847", "l": "PAK2 binds NCK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869560", "l": "The NOP2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40435", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015232", "l": "heme transmembrane transporter activity", "d": ["Enables the transfer of heme from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46179", "l": "2-methylpropanoate + ATP + CoA <=> 2-methylpropanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047501", "l": "(+)-neomenthol dehydrogenase activity", "d": ["Catalysis of the reaction: (+)-neomenthol + NADP+ = (2S,5R)-menthone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229132", "l": "AP4 binds APP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35263", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102060", "l": "endo-alpha-bergamotene synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate = (-)-endo-alpha-bergamotene + diphosphoric acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59592", "l": "ATP + beta-alanine + L-arginine = ADP + beta-alanyl-L-arginine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202127", "l": "eNOS synthesizes NO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24525", "l": "20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48491", "l": "all-trans-retinol--[retinol-binding protein] + NAD(+) <=> all-trans-retinal--[retinol-binding protein] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008802", "l": "betaine-aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41468", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.122", "l": "\"oryzalexin E synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72108", "l": "Na(+)(out) + O-acyl-(R)-carnitine(out) => Na(+)(in) + O-acyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635861", "l": "NUMB:ITCH binds GLI1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451310", "l": "Activation of Edited Kainate receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19730", "l": "acetoacetate + H(+) => acetone + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9007926", "l": "ATRX binds DAXX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.169", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40712", "l": "1-octadecanoylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61556", "l": "gibberellin A12 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A15 + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236964", "l": "Translocation of peptide bound MHC class I complex to cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877414", "l": "FOXP3 in complex with RUNX1 binds the CTLA4 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429730", "l": "PPM1L dephosphorylates multiphospho-CERT1-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.18.1", "l": "\"cathepsin X\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43508", "l": "2,5-diformylfuran + H2O = 2-(dihydroxymethyl)-5-formylfuran", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50270", "l": "(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112435", "l": "Formation of Elongin BC complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0031320", "l": "hexitol dehydrogenase activity", "d": ["Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14910", "l": "L-gulonate + NADP(+) => aldehydo-D-glucuronate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9834076", "l": "PINK1 is autophosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33872", "l": "(S)-2-ureidoglycine + H2O => glyoxylate + NH4(+) + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19308", "l": "3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174121", "l": "Association of Securin with Cdc20:APC/C complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74627", "l": "NADPH + 2 O2 + prefumagillin = acetaldehyde + fumagillin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26521", "l": "3-hydroxypropanoyl-CoA <=> acryloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13090", "l": "6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) => 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52760", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O = (Z)-1-(glycyl-L-cystein-S-yl)-2-phenylacetohydroximate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374663", "l": "DCC interaction with Ezrin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44298", "l": "4-hydroxy-5-methyl-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexadecanoyl-CoA + malonyl-CoA + methylmalonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69825", "l": "(22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106105", "l": "Ala-tRNA(Thr) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated ala-tRNA(thr)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637699", "l": "CpnT hydrolyses NAD+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445705", "l": "Release Of ADP From Myosin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390930", "l": "5-HT2 receptor can bind serotonin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12533", "l": "coenzyme B + methyl-coenzyme M => coenzyme M-coenzyme B heterodisulfide + methane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20157", "l": "a polyvinyl alcohol + 2n Fe(III)-[cytochrome c] = an oxidized polyvinyl alcohol + 2n Fe(II)-[cytochrome c] + 2n H(+)", "d": [], "t": []}, {"i": "EC:1.1.2.6", "l": "\"polyvinyl alcohol dehydrogenase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74866", "l": "(R)-salsolinol + S-adenosyl-L-methionine <=> H(+) + N-methyl-(R)-salsolinol + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52887", "l": "H2O + N-phenylhydroxylamine + 2 NADP(+) <=> 2 H(+) + 2 NADPH + nitrobenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170159", "l": "Translocation of Cdc25 to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34919", "l": "thiamine(in) = thiamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23630", "l": "a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788623", "l": "p-Y-STATs translocate to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64512", "l": "(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine = 6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2176491", "l": "NEDD4L binds phosphorylated linker region of SMAD2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58224", "l": "L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482571", "l": "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-74723", "l": "Endosome acidification (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19206", "l": "dCTP + 2 H2O => diphosphate + dUMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13967", "l": "L-homocysteine + NH4(+) + pyruvate => H2O + L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72919", "l": "4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43809", "l": "1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9796053", "l": "PRKCI phosphorylates NFE2L2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26461", "l": "ethylnitronate + FMNH2 + O2 <=> acetaldehyde + FMN + 2 H(+) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19410", "l": "cholate + NAD(+) => 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004015", "l": "adenosylmethionine-8-amino-7-oxononanoate transaminase activity", "d": ["Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8943279", "l": "GGT dimers hydrolyse GSH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21333", "l": "acetyl-CoA + D-glucosamine => CoA + H(+) + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933538", "l": "Recruitment of IRF7 to TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004081", "l": "bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity", "d": ["Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052725", "l": "inositol-1,3,4-trisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21860", "l": "3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate", "d": [], "t": []}, {"i": "EC:2.8.2.28", "l": "\"quercetin-3,3'-bissulfate 7-sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32642", "l": "(6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase] <=> (6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202127", "l": "eNOS synthesizes NO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75968", "l": "(6-hydroxyhexanoyl)n + H2O => (6-hydroxyhexanoyl)n-1 + 6-hydroxyhexanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33216", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64409", "l": "2 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) => 2 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38710", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625848", "l": "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37449", "l": "H(+) + H2O + tetracenomycin D3 => O2 + tetracenomycin F1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351207", "l": "Spermine  => N-acetylated spermine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12031", "l": "H2O + L-5-carboxymethylhydantoin <=> H(+) + N-carbamoyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27783", "l": "4-hydroxybenzoate + all-trans-octaprenyl diphosphate => 4-hydroxy-3-all-trans-octaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38073", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204850", "l": "Interaction of Tie2 and Dok-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482759", "l": "MLCL is hydrolyzed to DLCL by PLA2G4A (IM) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49380", "l": "5-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,20-dihydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13569", "l": "a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a beta-D-GalNAc-(1->4)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.165", "l": "\"N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445700", "l": "Myosin Binds ATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40862", "l": "(9Z)-hexadecenoyl-CoA + FAD + H(+) <=> (2E,9Z)-hexadecadienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008953", "l": "penicillin amidase activity", "d": ["Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005105", "l": "type 1 fibroblast growth factor receptor binding", "d": ["Binding to a type 1 fibroblast growth factor receptor (FGFR1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38139", "l": "(9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698923", "l": "Binding of the major capsid protein (MCP) to the pPR-AP:pAP complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50388", "l": "5a,11a-dehydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrooxytetracycline + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.234", "l": "\"12-dehydrotetracycline 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434989", "l": "SEMA7A binds to PLXNC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73153", "l": "CoA(in) + FMN(out) => CoA(out) + FMN(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51091", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878117", "l": "RUNX3 binds ZFHX3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43022", "l": "2-aminoprop-2-enoate + L-homocysteine => L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26170", "l": "fumarate + H(+) + pyruvate => 3-fumarylpyruvate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675815", "l": "PI4P transports from the Golgi membrane to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982017", "l": "Active G alpha (q) binds RGS proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75543", "l": "(3R)-3-[(carboxylmethyl)amino]decanoate + H(+) + holo-[ACP] = (2E)-decenoyl-[ACP] + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38690", "l": "(4R)-hydroxysphinganine(in) + ATP + H2O <=> (4R)-hydroxysphinganine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71144", "l": "3-hydroxyhispidin + O2 => (E)-caffeoylpyruvate + CO2 + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65918", "l": "H2O + kynurenate + L-alanine => L-kynurenine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78875", "l": "a medium-chain (3R)-hydroxyacyl-CoA + NAD(+) = a medium-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12980", "l": "H2O + N-phosphocreatine <=> creatine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52840", "l": "UDP-alpha-D-glucose + vanillate = 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12995", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + reduced [electron-transfer flavoprotein] => cyclohex-1-ene-1-carbonyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42911", "l": "S-adenosyl-L-methionine + uridine(1939) in 23S rRNA <=> 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78962", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.38", "l": "\"cathepsin K\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73079", "l": "S-adenosyl-L-methionine + scutellarein = S-adenosyl-L-homocysteine + scutellarein 7-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58945", "l": "6 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 12 H(+) + malonyl-CoA + 6 NADPH => 7 CO2 + 8 CoA + demethyldeoxyspectinabilin + 5 H2O + 6 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19324", "l": "N,N-dimethylaniline N-oxide <=> formaldehyde + N-methylaniline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623427", "l": "IGFBP1 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41190", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69866", "l": "a uridine in mRNA + S-adenosyl-L-methionine <=> a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102581", "l": "cyanidin 3-O-glucoside-p-coumaroyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 4-coumaryl-CoA + H+ = cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29526", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76579", "l": "(2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + 2 H(+) + NADPH = (6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58118", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP => L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77362", "l": "2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine <=> 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9854672", "l": "FAD attaches to SDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52042", "l": "2-aminoprop-2-enoate + S-sulfanyl-L-cysteine => L-cystine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12699", "l": "ADP + dGDP => ATP + dGMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37207", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54588", "l": "S-adenosyl-L-methionine + uridine in 25S rRNA = H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49504", "l": "phosphinomethylmalate = phosphinomethylisomalate", "d": [], "t": []}, {"i": "EC:4.2.1.166", "l": "\"phosphinomethylmalate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22329", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) => diphosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0005507", "l": "copper ion binding", "d": ["Binding to a copper (Cu) ion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60990", "l": "(E)-hex-2-enal + H(+) + NADH => (E)-hex-2-en-1-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11660", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": [], "t": []}, {"i": "EC:3.5.1.89", "l": "\"N-acetylglucosaminylphosphatidylinositol deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "64.8980293377588", "identifiers": [{"i": "GO:0016903", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "58.759852727885885", "identifiers": [{"i": "GO:0022804", "l": "active transmembrane transporter activity", "d": ["Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112690", "l": "PTPN11 binds CBL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14856", "l": "4-chlorobenzoyl-CoA + H2O <=> 4-hydroxybenzoyl-CoA + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10176", "l": "(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) = (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.397", "l": "\"beta-methylindole-3-pyruvate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730842", "l": "PI3K associates with phosphorylated GAB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62502", "l": "AMP + H(+) + L-arginyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-arginyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68827", "l": "(2E)-geranyl diphosphate <=> (Z)-beta-ocimene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876472", "l": "NPC2 binds CHOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796079", "l": "NFE2L2 dependent ABCC3 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214953", "l": "Full-length SNK is cleaved by GD serine protease (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-901047", "l": "Binding of ERp57 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69859", "l": "a uridine in 12S rRNA + S-adenosyl-L-methionine = a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0015185", "l": "gamma-aminobutyric acid transmembrane transporter activity", "d": ["Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58324", "l": "beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12540", "l": "ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)", "d": [], "t": []}, {"i": "EC:6.1.1.7", "l": "\"alanine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839638", "l": "CTNNB1 T41 mutants aren't phosphorylated by GSK3beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49026", "l": "2-iminio-3-(indol-3-yl)propanoate + H2O2 => L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77149", "l": "1D-myo-inositol 1,4,5-trisphosphate + phosphate => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32591", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O = (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24294", "l": "CoA + H(+) + N-acetyl-L-glutamate => acetyl-CoA + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20970", "l": "2-dehydro-3-deoxy-L-arabinonate + H2O => L-arabinonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102905", "l": "valencene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = (+)-valencene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199206", "l": "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111930", "l": "Adenylate cyclase produces cAMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086086", "l": "voltage-gated potassium channel activity involved in AV node cell action potential repolarization", "d": ["Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11096", "l": "NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102904", "l": "germacrene C synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = germacrene C + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64259", "l": "dodecanoyl-CoA + glycine <=> CoA + H(+) + N-dodecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22383", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) + n H2O <=> [(1->4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62603", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 5-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693198", "l": "RHOD binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109860", "l": "MAP2K1 phosphorylates MAPK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981539", "l": "C3b binds to cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11551", "l": "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O <=> 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33619", "l": "ATP + CoA + tetradecanoate = AMP + diphosphate + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379861", "l": "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.4", "l": "\"acyl-lipid (11-3)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29869", "l": "ADP + IDP => AMP + ITP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39622", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH <=> (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15026", "l": "S-adenosyl-L-methionine + xanthosine => 7-methylxanthosine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32417", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADH => (1S,2S,4R)-isodihydrocarveol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50530", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161620", "l": "PGH2 is isomerised to PGD2 by PTGDS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106409", "l": "cyclic-di-AMP phosphodiesterase activity", "d": ["Catalysis of the reaction: 3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-5')-adenosine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.34", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11231", "l": "(2S)-flavan-4-ol + NADP(+) <=> (2S)-flavanone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950522", "l": "p-STAT1:p-STAT4 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70905", "l": "(2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247840", "l": "WLS binds WNT ligands in the Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23695", "l": "(R)-malate <=> H2O + maleate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71861", "l": "glycochenodeoxycholate(in) => glycochenodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112042", "l": "Opioid binds MOR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22273", "l": "(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] => (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68138", "l": "(R)-1-phenylethanol + NADP(+) => acetophenone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109639", "l": "Formation of the closed pre-initiation complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264458", "l": "Proteasome mediated degradation of COP1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-422048", "l": "Acyl Ghrelin and C-Ghrelin are secreted (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0042007", "l": "interleukin-18 binding", "d": ["Binding to interleukin-18."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.134", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5212679", "l": "DNMT3A binds Me2sR4-HIST1H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57908", "l": "ATP + L-glutamyl-tRNA(Gln) = 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39911", "l": "(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.107", "l": "\"beta-methylphenylalanine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11466", "l": "glutathione disulfide + 2 L-homocysteine => 2 glutathione + L,L-homocystine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2484822", "l": "Kinetochore assembly (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102071", "l": "9,10-epoxy-18-hydroxystearate hydrolase activity", "d": ["Catalysis of the reaction: 9,10-epoxy-18-hydroxystearate + H2O = 9,10,18-trihydroxystearate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031005", "l": "filamin binding", "d": ["Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17206", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate => adenosine 3',5'-bisphosphate + H(+) + quercetin 3,4'-bissulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706312", "l": "Active FLT3 binds to LCK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61210", "l": "H(+) + nitrite + S-(guanosine 3',5'-cyclic phosphate)-L-cysteinyl-[protein] => 8-nitro-cGMP + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177937", "l": "Phosphorylation of EGFR by SRC kinase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654515", "l": "KAL1 binds HS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58452", "l": "N-terminal N,N-dimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211206", "l": "Translocation of DFF to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61957", "l": "1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46932", "l": "2-epi-5-epi-valiolone 7-phosphate = 5-epi-valiolone 7-phosphate", "d": [], "t": []}, {"i": "EC:5.1.3.35", "l": "\"2-epi-5-epi-valiolone 7-phosphate 2-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73760", "l": "guanosine(2553) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(2553) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729454", "l": "SARS-CoV-2 N protein binds STAT1, STAT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948832", "l": "RNF146 polyubiquitinates PARylated PTEN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130640", "l": "Recruitment of clathrin coated vesicle by Ii (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60142", "l": "3-oxotetradecanoyl-CoA + CO2 + CoA => dodecanoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36777", "l": "alpha-L-Fuc-(1->2)-[alpha-D-Gal-(1->3)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14431", "l": "a [oligopeptide](out) + ADP + H(+) + phosphate => a [oligopeptide](in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3321805", "l": "NSL acetylates histone H4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40494", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16316", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O <=> 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990422", "l": "glyoxalase (glycolic acid-forming) activity", "d": ["Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17511", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+) => H2O + thiamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176609", "l": "cholesterol + PAPS => cholesterol sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44978", "l": "CoA + O-propanoyl-(R)-carnitine => (R)-carnitine + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2219524", "l": "PDPK1 binds PIP2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62695", "l": "2 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + O2 <=> 2 H(+) + 2 H2O + 2 tellimagrandin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19801", "l": "(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.3", "l": "\"pantetheine-phosphate adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.19", "l": "\"glycine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780958", "l": "SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647631", "l": "GSDMD (1-275) binds PIPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465924", "l": "OPN1LW binds 11cRAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047825", "l": "D-lactate-2-sulfatase activity", "d": ["Catalysis of the reaction: (R)-2-O-sulfolactate + H2O = (R)-lactate + H+ + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35661", "l": "GDP + H(+) + mannosylinositol phosphorylphytoceramide => an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75405", "l": "3-aminopropanal + L-alanine => propane-1,3-diamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25977", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31912", "l": "beta-D-fructose 1,6-bisphosphate + methylglyoxal => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:1990189", "l": "peptide-serine-alpha-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + N-terminal L-serine in peptide = CoA + N-acetyl-L-serine-peptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246506", "l": "botC HC:LC binds GT1b on the target cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42391", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> beta-D-gentiobiosyl crocetin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876868", "l": "ECE1 cleaves EDN1(53-90) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25216", "l": "H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.59", "l": "\"caspase-6\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54422", "l": "5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+) => 3',3'-c-di-AMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.71648590403835", "identifiers": [{"i": "GO:0016004", "l": "phospholipase activator activity", "d": ["Binds to and increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75087", "l": "32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71413", "l": "3,3',5-triiodo-L-thyronine(in) + L-tryptophan(out) => 3,3',5-triiodo-L-thyronine(out) + L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58332", "l": "(E)-non-2-en-1-ol + NADP(+) = (E)-non-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419644", "l": "Transphosphorylation of pLIMK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0047141", "l": "glutathione-cystine transhydrogenase activity", "d": ["Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70040", "l": "3-dehydro-6-deoxoteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 3-dehydroteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106242", "l": "kolavenyl diphosphate synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27751", "l": "2'-deoxyinosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977629", "l": "Displacement of C2a/Bb by CR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26035", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66675", "l": "4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) <=> 5,7-dihydroxy-4-methylphthalide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102688", "l": "dihydrozeatin UDP glycosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin = H+ + 9-(alpha-D-glucosyl)dihydrozeatin + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77994", "l": "9-hydroxy-octadecanoate + a 1,2-diacyl-sn-glycerol <=> 9-(acyloxy)-octadecanoate + a 1-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9844955", "l": "CLN3 transports GalCer to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69810", "l": "benzoyl-AMP + CoA <=> AMP + benzoyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52309", "l": "2-hydroxyglutarate + NADP(+) => 2-oxoglutarate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63047", "l": "H2O + mevastatin <=> H(+) + mevinic carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694794", "l": "mRNA3 is translated to protein 3a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984609", "l": "Kinesin-8 is a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28195", "l": "(2S)-3-sulfolactate + NAD(+) => 3-sulfopyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9604328", "l": "AKT1 phosphorylates NOTCH4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748996", "l": "GST dimers cleave AZA to 6MP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047239", "l": "hydroxymandelonitrile glucosyltransferase activity", "d": ["Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = H+ + taxiphyllin + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72604", "l": "(E)-sinapate + ATP + H(+) => (E)-sinapoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425861", "l": "Activation of Protein Kinase C novel isoforms (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67907", "l": "glutaryl-CoA + H(+) + malonyl-[ACP] <=> 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62599", "l": "(S)-8-oxocitronellyl enol + NAD(+) <=> (6E)-8-oxogeranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.539730406838608", "identifiers": [{"i": "GO:0036094", "l": "small molecule binding", "d": ["Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30680", "l": "D-cellobiose + H2O => beta-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47147", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42139", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062068", "l": "chloroplast photosystem II binding", "d": ["Binding to a chloroplast photosystem II."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.17", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27387", "l": "maleate + NH4(+) => H2O + maleamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13082", "l": "biotin amide + H2O => biotin + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0001848", "l": "complement binding", "d": ["Binding to a component or product of the complement cascade."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047603", "l": "acetoacetyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: acetoacetyl-CoA + H2O = acetoacetate + CoA + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78473", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.101", "l": "\"DNA primase DnaG\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66326", "l": "iodide(in) => iodide(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10006", "l": "benzyl thiocyanate => benzyl isothiocyanate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70592", "l": "PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46612", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20977", "l": "a primary nitroalkane + H2O + O2 => an aldehyde + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38272", "l": "(3S)-citramalyl-CoA => 3-methylfumaryl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.25.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11438", "l": "4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O => 4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2464822", "l": "RDH12 reduces atRAL to atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38280", "l": "(3R)-citramalate + succinyl-CoA => (3R)-citramalyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46431", "l": "4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48998", "l": "2-hydroxy-6-oxo-2,4-heptadienoate + H(+) => 3-methylcatechol + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656252", "l": "Defective OGG1 mutants do not excise FapyG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.169", "l": "\"protein O-GlcNAcase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60119", "l": "2-oxoglutarate + methylphosphonate + O2 <=> CO2 + hydroxymethylphosphonate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45630", "l": "holo-[CmaA peptidyl-carrier protein] + L-alloisoleucyl-[CmaD peptidyl-carrier protein] => holo-[CmaD peptidyl-carrier protein] + L-alloisoleucyl-[CmaA peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14534", "l": "creatinine + H2O => creatine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24404", "l": "(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA", "d": [], "t": []}, {"i": "EC:4.1.3.4", "l": "\"hydroxymethylglutaryl-CoA lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47683", "l": "D-galactosamine 6-phosphate + H2O <=> D-tagatopyranose 1-phosphate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801195", "l": "STEAP3 binds BNIP3L (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43688", "l": "N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate = L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16766", "l": "D-mannitol + NADP(+) => D-fructose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71404", "l": "2alpha-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] => 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5678706", "l": "ABCB4 transports PC from plasma membrane to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33627", "l": "ATP + CoA + decanoate = AMP + decanoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64408", "l": "2 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = 2 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74492", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B => yaequinolone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984963", "l": "EBI3 gene transcription and translation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791218", "l": "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21400", "l": "2-oxoglutarate + CoA + NADP(+) = CO2 + NADPH + succinyl-CoA", "d": [], "t": []}, {"i": "EC:1.2.1.52", "l": "\"oxoglutarate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77898", "l": "H2O + N(6)-(1-deoxy-beta-D-fructopyranos-1-yl)-L-lysine + O2 <=> (1-deoxy-D-fructos-1-yl)amine + (S)-2-amino-6-oxohexanoate + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645672", "l": "p14ARF translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46400", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663246", "l": "RORA, EP300 bind NPAS2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68792", "l": "alpha-NAD(+) + H2O = ADP-D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65638", "l": "CoA + H(+) + N-tetracosanoylsphinga-(4E,8E)-dienine => sphinga-(4E,8E)-dienine + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5221014", "l": "TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624798", "l": "LBR binds KPNB1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870457", "l": "FarC-PTP4A2 binds RABGGTB (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.24", "l": "\"tocopherol cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983519", "l": "IL35 binds IL12RB2:IL12RB2 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30257", "l": "2 a ubiquinone + 2 H2O => 2 a ubiquinol + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46574", "l": "5-hexenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690245", "l": "p-T182 MAPKAPK5 binds DNAJB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31349", "l": "2-cis-(+)-abscisate + beta-D-glucose + H(+) => (+)-abscisic acid D-glucopyranosyl ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42846", "l": "7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide => 6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55577", "l": "4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine => H(+) + psilocybin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38468", "l": "a 2-acylglycerol + an acyl-CoA => a 2,3-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35749", "l": "7-epizingiberene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9630967", "l": "RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9671145", "l": "DKC1 binds SHQ1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72635", "l": "eIF4F binds to mRNP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20941", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41703", "l": "1-O-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + glutarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13609", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.150", "l": "\"1-phosphatidylinositol-3-phosphate 5-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110232", "l": "Cleavage of thymine by MBD4 glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44033", "l": "9,10-epoxy-(12Z)-octadecenoate + H2O => 9,10-dihydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9834945", "l": "PINK1 phosphorylates Ub on MOM proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0015172", "l": "acidic amino acid transmembrane transporter activity", "d": ["Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3."], "t": []}, {"i": "REACT:R-HSA-372448", "l": "SLC25A12,13 exchange L-Glu and L-Asp (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835358", "l": "p-TARBP2 binds PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74872", "l": "RDH10,11 oxidise 11cROL to 11cRAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54409", "l": "1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62701", "l": "H2O + naphtopyrone YWA1 => acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1011598", "l": "DOCKs bind to RhoGEFs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71592", "l": "2-oxoglutarate(out) + malonate(in) => 2-oxoglutarate(in) + malonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.385", "l": "\"sterol 27-beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30197", "l": "9,9',15-tri-cis-zeta-carotene + plastoquinol-9 => 15,9'-di-cis-phytofluene + plastoquinone-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56633", "l": "H2O + neryl diphosphate => 1,8-cineole + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070405", "l": "ammonium ion binding", "d": ["Binding to ammonium ions (NH4+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42559", "l": "uridine(2819) in 21S rRNA <=> pseudouridine(2819) in 21S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149519", "l": "MMACHC decyanates CNCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190829", "l": "Lysosomal degradation of gap junction plaques (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814695", "l": "PERP binds desmosomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357483", "l": "RAC1 binds PAK1-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701549", "l": "AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264622", "l": "Cho is acetylated to AcCho by CHAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034714", "l": "type III transforming growth factor beta receptor binding", "d": ["Binding to a type III transforming growth factor beta receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72562", "l": "estrone 3-sulfate(out) + pentanoate(in) <=> estrone 3-sulfate(in) + pentanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189439", "l": "ALAD condenses 2 dALAs to form PBG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852552", "l": "MST1R autophosphorylates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103074", "l": "glucose-6-phosphate 3-dehydrogenase activity", "d": ["Catalysis of the reaction: NAD + D-glucopyranose 6-phosphate = NADH + H+ + 3-dehydro-D-glucose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16574", "l": "2-oxoglutarate + 4-(phosphooxy)-L-threonine => (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2533874", "l": "Laminin-511 degradation by MMP14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31463", "l": "crocetin + UDP-alpha-D-glucose = beta-D-glucosyl crocetin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0051861", "l": "glycolipid binding", "d": ["Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78071", "l": "a 2-acyl-sn-glycerol 3-phosphate + H2O = a 2-acylglycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22606", "l": "D-fructose => D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74059", "l": "PDE6 hydrolyses cGMP to GMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76661", "l": "butanoate + 2 H(+) + NADPH => butanal + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218806", "l": "FYN autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33014", "l": "(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25450", "l": "(+)-guaia-6,9-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444848", "l": "Relaxin 3 receptor 1 binds relaxin 3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008784", "l": "alanine racemase activity", "d": ["Catalysis of the reaction: L-alanine = D-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61129", "l": "O2 + quercetin + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + myricetin + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218805", "l": "PKC autophosphorylates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44371", "l": "Cr(6+) + 2 NADPH + O2 <=> Cr(3+) + 2 H(+) + 2 NADP(+) + superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814096", "l": "ARL1:GTP binds SCOC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193665", "l": "MYD88 dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047397", "l": "dolichylphosphate-glucose phosphodiesterase activity", "d": ["Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209252", "l": "CI75 inhibits transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63512", "l": "biphenyl-2,2'-diol + H(+) + NADH + O2 = biphenyl-2,2',3-triol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15861", "l": "3-ADP-2-phosphoglycerate + H2O = 3-ADP-glycerate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.28", "l": "\"ADP-phosphoglycerate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54623", "l": "2-oxoglutarate + eicosanoyl-CoA + O2 <=> 2-hydroxyeicosanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74397", "l": "2 (S)-lactate(out) + prostaglandin E1(in) => 2 (S)-lactate(in) + prostaglandin E1(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77447", "l": "4-methoxybenzaldehyde + hydrogen cyanide = (2S)-2-hydroxy-2-(4-methoxyphenyl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13289", "l": "a dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.15", "l": "\"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22300", "l": "a flavonol + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.91", "l": "\"flavonol 3-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140847", "l": "factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008030", "l": "neuronal pentraxin receptor activity", "d": ["Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047300", "l": "pyridoxamine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: pyridoxamine + pyruvate = L-alanine + pyridoxal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49335", "l": "2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52739", "l": "(Z)-indolylmethyl desulfoglucosinolate + 3'-phosphoadenylyl sulfate <=> (Z)-glucobrassicin + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170846", "l": "TGFBR2 recruits TGFBR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36283", "l": "1,7-dimethylxanthine + H(+) + NADPH + O2 = 7-methylxanthine + formaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53470", "l": "(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106344", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP", "d": ["Catalysis of the reaction: 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H+ + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]."], "t": []}, {"i": "RHEA:65756", "l": "2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43518", "l": "2-carboxy-5-(dihydroxymethyl)furan => 2-carboxy-5-formylfuran + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65843", "l": "ATP(out) + Mg(2+)(out) + phosphate(in) <=> ATP(in) + Mg(2+)(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66870", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate => 3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27940", "l": "glycine + glyoxylate => (3R)-3-hydroxy-D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61381", "l": "2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O => 2,4-dinitrophenyl-S-glutathione(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624800", "l": "CDK1 phosphorylates LBR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55122", "l": "(3R)-hydroxy-4-methylhexanoyl-[ACP] + NADP(+) => 4-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10362", "l": "3-(2-hydroxyphenyl)propanoate + H(+) => 3,4-dihydrocoumarin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37272", "l": "ATP + H2O + L-alanyl-L-glutamine(out) => ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10211", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) <=> H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63121", "l": "(11Z)-eicosenamide + H2O => (11Z)-eicosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65393", "l": "4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH => (8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78583", "l": "acetyl-CoA + eicosanoyl-CoA = 3-oxodocosanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14152", "l": "luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47212", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29644", "l": "D-maltoheptaose + H2O => alpha-D-glucose + D-maltohexaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4395227", "l": "CCND1:CREBBP binds NOTCH1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102402", "l": "2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity", "d": ["Catalysis of the reaction: 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside + H2O = 2-phenylethanol + 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047998", "l": "hyoscyamine (6S)-dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-hyoscyamine + O2 = (6S)-6-hydroxyhyoscyamine + CO2 + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31626", "l": "L-olivosyl-oleandolide + S-adenosyl-L-methionine <=> H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20976", "l": "a primary nitroalkane + H2O + O2 = an aldehyde + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634228", "l": "TRAF1 is cleaved by caspases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0046030", "l": "inositol trisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39942", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008475", "l": "procollagen-lysine 5-dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48572", "l": "3,5-dichlorocatechol + O2 = (2E,4E)-2,4-dichloromuconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68979", "l": "glycoursodeoxycholate + NADP(+) <=> 7-oxoglycolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49125", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate => H2O + NADP(+) + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76575", "l": "4-deoxy-L-threo-hex-4-enopyranuronate = 5-dehydro-4-deoxy-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69673", "l": "(2S)-naringenin + beta-D-glucose => (2S)-naringenin 7-O-beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68326", "l": "1D-myo-inositol 2-phosphate + phosphate => 1D-myo-inositol 2,5-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48539", "l": "1-beta-D-galactosyl-2,3-didodecanoyl-sn-glycerol + H2O <=> 1-beta-D-galactosyl-dodecanoyl-sn-glycerol + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20214", "l": "L-lysyl-[lipoyl-carrier protein] + N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] => L-lysyl-[glycine-cleavage complex H protein] + N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46298", "l": "6beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10252", "l": "H(+) + hydrogen sulfide + O-phospho-L-serine = L-cysteine + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.65", "l": "\"O-phosphoserine sulfhydrylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53361", "l": "5,6-dihydrouridine(47) in tRNA + NADP(+) => H(+) + NADPH + uridine(47) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193636", "l": "p75NTR interacts with the NOGO receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76142", "l": "D-gluconate(in) <=> D-gluconate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64781", "l": "S-benzyl-L-cysteine => 2-aminoprop-2-enoate + benzylthiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55750", "l": "coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin] => coenzyme B + coenzyme M + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018711", "l": "benzoyl acetate-CoA thiolase activity", "d": ["Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66713", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811504", "l": "AKT1 dephosphorylation by PP2A-B56-beta,gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65487", "l": "hexan-1-ol + hexanoyl-CoA <=> CoA + hexyl hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43349", "l": "cholesteryl (9Z-octadecenoate)(in) => cholesteryl (9Z-octadecenoate)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36722", "l": "hexacosenoyl-CoA + sphinganine <=> CoA + H(+) + N-hexacosenoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73461", "l": "3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide b => 5 H(+) + 2 O2 + protochlorophyllide a + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76354", "l": "oxaloacetate(in) + sulfate(out) <=> oxaloacetate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706837", "l": "AR binds AR antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12950", "l": "D-fuconate => 2-dehydro-3-deoxy-D-fuconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77990", "l": "9-hydroxy-octadecanoate + a triacylglycerol <=> 9-(acyloxy)-octadecanoate + a 1,3-diacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2872444", "l": "SLC9B1/C2 exchange Na+ for H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31625", "l": "H(+) + L-oleandrosyl-oleandolide + S-adenosyl-L-homocysteine => L-olivosyl-oleandolide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0048258", "l": "3-ketoglucose-reductase activity", "d": ["Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851147", "l": "miR-21 RISC binds DNMT1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66948", "l": "acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate = alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.303", "l": "\"alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und 2(IV)-O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12648", "l": "CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25821", "l": "H2O + O2 + spermidine => 4-aminobutanal + H2O2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13389", "l": "glutaryl-CoA + 2 H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + CO2 + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.6", "l": "\"glutaryl-CoA dehydrogenase (ETF)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23184", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102061", "l": "endo-beta-bergamotene synthase activity", "d": ["Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate = (+)-endo-beta-bergamotene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211247", "l": "Cleavage of DNA by DFF40 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31313", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+) => (2R)-3-phosphoglycerate + ADP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624954", "l": "INPP5E translocates to the primary cilium (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211948", "l": "CYP3A4 can N-demethylate loperamide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9865449", "l": "Metallochaperone inserts Cu2+ into MT-CO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12770", "l": "A + D-gluconate => 2-dehydro-D-gluconate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44903", "l": "D-galactono-1,4-lactone + H2O <=> D-galactonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162194", "l": "COQ7:COQ9 octamer hydroxylates DMQ10H2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69733", "l": "AMP + H(+) + phenylacetyl-CoA => CoA + phenylacetyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51407", "l": "H2O + L-arginine + O2 <=> 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48295", "l": "a ganglioside GM1 + GDP-beta-L-fucose <=> a ganglioside Fuc-GM1 + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70005", "l": "cathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-oxocampestanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38771", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32030", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-alpha-cuprenene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835443", "l": "STAT1,STAT3 binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38553", "l": "(R)-2-hydroxyhexadecanoate + 2 Fe(III)-[cytochrome b5] + H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729279", "l": "Nucleoprotein is ADP-ribosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193399", "l": "Cholate is translocated from the peroxisomal matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199839", "l": "AKT can phosphorylate RSK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211346", "l": "NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784765", "l": "p-Y705-STAT3 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38268", "l": "2-methylfumaryl-CoA => 3-methylfumaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27726", "l": "5-dehydro-4-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856460", "l": "MITF-M-dependent RAB27A expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12960", "l": "an acetyl ester + H2O <=> acetate + an aliphatic alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418856", "l": "Activation of Rac1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839053", "l": "AFG3L2:SPG7 binds SMDT1 (EMRE) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13328", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine <=> 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70158", "l": "6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204871", "l": "Interaction of Tie2 and Grb2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9825751", "l": "HINT1 binds MITF-M (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17059", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP] => a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429699", "l": "CERT1-2 complex binds ceramide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48603", "l": "[protein-PII]-uridylyl-L-tyrosine + H2O <=> [protein-PII]-L-tyrosine + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247510", "l": "MARCO:ligand is endocytosed (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68386", "l": "(2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate => (2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088152", "l": "FOXM1 stimulates CDC25A transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603982", "l": "FUT2 transfers Fuc to LeA to form LeB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39060", "l": "26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050076", "l": "maleate isomerase activity", "d": ["Catalysis of the reaction: maleate = fumarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193665", "l": "MYD88 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74511", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B = aspoquinolone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28924", "l": "H(+)(in) + L-phenylalanine(in) => H(+)(out) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102913", "l": "3-aminomethylindole N-methyltransferase activity", "d": ["Catalysis of the reaction: indol-3-ylmethylamine + S-adenosyl-L-methionine = H+ + N-methyl-3-aminomethylindole + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57043", "l": "aldehydo-D-apiose <=> D-apiofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78155", "l": "RNA(n)-3'-guanine ribonucleotide = 2',3'-cyclophospho-GMP + RNA(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44398", "l": "1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA => 1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9015111", "l": "Factor Xa inhibitors binds Xa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76785", "l": "1,9-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134946", "l": "DDX41 ubiquitination by TRIM21 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70670", "l": "a fatty acyl-[ACP] + L-lysyl-[protein] <=> H(+) + holo-[ACP] + N(6)-(fatty acyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3159253", "l": "MMAB adenosylates cob(I)alamin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40524", "l": "a quinone + succinate => a quinol + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.76", "l": "\"myeloblastin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69292", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate = goitrin + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71775", "l": "SUCLG1/G2 cleaves succinyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.165", "l": "\"methyl halide transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683735", "l": "CHEK2 is recruited to DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21304", "l": "ent-kaur-16-en-19-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61186", "l": "H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP => quercitrin + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27597", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 5 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-445704", "l": "Calcium Binds Caldesmon (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46557", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2 => 7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070320", "l": "inward rectifier potassium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37761", "l": "1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2870221", "l": "E-selectin binds E-selectin ligand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51632", "l": "all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0004346", "l": "glucose-6-phosphatase activity", "d": ["Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "67.136185332556494", "identifiers": [{"i": "GO:0048018", "l": "receptor ligand activity", "d": ["The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same cell that expresses the receptor. Ligands may also be expressed at the plasma membrane of an adjacent cell (e.g. Notch ligands) or be secreted and diffuse extracellularly from their point of origin to the receiving cell (e.g. interleukins)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013009", "l": "RHOA binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64761", "l": "H2O + S-ethyl-L-cysteine => ethanethiol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57863", "l": "(E)-6-hydroxyferuloyl-CoA <=> CoA + scopoletin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1462005", "l": "pro-defensin alpha 5 is secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030373", "l": "high molecular weight B cell growth factor receptor activity", "d": ["Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193653", "l": "NGF homodimer binds to p75NTR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417898", "l": "P2Y4 receptor can bind to UTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106286", "l": "(E)-caffeate-CoA ligase activity", "d": ["Catalysis of the reaction: (E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate."], "t": []}, {"i": "RHEA:36299", "l": "(E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050328", "l": "tetrahydroberberine oxidase activity", "d": ["Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213241", "l": "Formation of nonameric complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9854405", "l": "Frataxin transfers Fe2+ to ACO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416698", "l": "SEMA5A binds to PLXNB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102382", "l": "rebaudioside B glucosyltransferase activity", "d": ["Catalysis of the reaction: rebaudioside B + UDP-alpha-D-glucose = rebaudioside A + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014294", "l": "RAC2 binds effectors at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45001", "l": "(R)-carnitine + 3-hydroxybutanoyl-CoA => CoA + O-3-hydroxybutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23747", "l": "2-oxoglutarate + L-histidinol phosphate <=> 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-990478", "l": "Kinesin-14 is a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54173", "l": "H2O + N(6)-acyl-L-lysyl-[protein] + NAD(+) => 2''-O-acyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41413", "l": "1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28951", "l": "H(+)(in) + L-arabinose(in) = H(+)(out) + L-arabinose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654669", "l": "Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822437", "l": "DIS3L2 hydrolyzes uridylated mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944247", "l": "Association of procollagen type VI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69541", "l": "GTP + streptomycin => 6-O-guanylylstreptomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10398", "l": "a 2-oxocarboxylate + H(+) + NADH + NH4(+) => an L-alpha-amino acid + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71401", "l": "OGDH dimer decarboxylates 2-OG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26156", "l": "D-mannose + NADP(+) = 2-dehydro-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636297", "l": "PtpA binds TRIM27 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640872", "l": "USP34 deubiquitinates AXIN1,AXIN2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851084", "l": "JUNB dimer binds GZMB promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033832", "l": "alpha,alpha-trehalose phosphorylase (configuration-retaining) activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656947", "l": "OGG1beta translocates to mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58356", "l": "2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + L-arginyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69116", "l": "Formation of Okazaki fragments (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69026", "l": "H2O + N,N-dihydroxy-L-aspartate + NADP(+) => H(+) + N-hydroxy-L-aspartate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34603", "l": "15-methylhexadecasphinganine + a fatty acyl-CoA = CoA + H(+) + N-acyl-15-methylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799431", "l": "TP53 binds HIPK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627802", "l": "SLC26A4 transports I- from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877620", "l": "ECE2 cleaves EDN1(53-90) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63887", "l": "H2O2 + L-tyrosine <=> H2O + L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9691421", "l": "BTK binds BTK inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851352", "l": "CCR8 binds CCL1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017797", "l": "NOTCH3 binds YBX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030624", "l": "U6atac snRNA binding", "d": ["Binding to a U6atac small nuclear RNA (U6atac snRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17334", "l": "O-acetyl-L-serine + zeatin => acetate + H(+) + L-lupinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61475", "l": "a sphingoid base + hexadecanoyl-CoA <=> an N-hexadecanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77242", "l": "pre-pseudomonine <=> pseudomonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73919", "l": "2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+) = H2O + norlichexanthone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42937", "l": "S-adenosyl-L-methionine + uridine(32) in tRNA => 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22916", "l": "4'-hydroxyacetophenone + H(+) + NADPH + O2 = 4-acetoxyphenol + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.84", "l": "\"4-hydroxyacetophenone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55016", "l": "H(+) + menthone + NADPH + O2 = 7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944236", "l": "Association of procollagen type XIV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12093", "l": "(S)-acetoin => (R)-acetoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15312", "l": "(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 4 H(+) + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388811", "l": "CD28 homodimer binds B7-1 homodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23194", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004550", "l": "nucleoside diphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12722", "l": "putrescine + S-adenosyl 3-(methylsulfanyl)propylamine => H(+) + S-methyl-5'-thioadenosine + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102253", "l": "neoagarobiose 1,3-alpha-3,6-anhydro-L-galactosidase activity", "d": ["Catalysis of the reaction: neoagarobiose + H2O = 3,6-anhydro-alpha-L-galactopyranose + beta-D-galactoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58147", "l": "acetate + ATP + cytidine(34) in elongator tRNA(Met) <=> AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61837", "l": "ergosterol + UDP-alpha-D-glucose => ergosteryl 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63222", "l": "5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine => 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836270", "l": "TFAP2A binds TFAP2C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38845", "l": "1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788385", "l": "The complex of ATR and ATRIP is recruited to ICL-DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66013", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] => [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73892", "l": "MGMT/hAGT mediated DNA Damage Reversal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855189", "l": "I(1,4,5,6)P4 transports from the ER lumen to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70233", "l": "(S)-2-benzoylsuccinyl-CoA + H(+) + NADH => (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44265", "l": "eicosanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-nonadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9824732", "l": "G or G analog binds C-ter TLR7 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047889", "l": "ferredoxin-nitrate reductase activity", "d": ["Catalysis of the reaction: nitrite + H2O + 2 oxidized ferredoxin = nitrate + 2 reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75261", "l": "3''-dehydroisoorientin + H2O2 => isoorientin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43921", "l": "(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38874", "l": "uridine(2457) in 23S rRNA <=> pseudouridine(2457) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15509", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.144", "l": "\"beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31819", "l": "(2E,6E)-farnesyl diphosphate = 5-epi-alpha-selinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.90", "l": "\"5-epi-alpha-selinene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182986", "l": "CBL-mediated ubiquitination of CIN85 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675194", "l": "Activated MAPK phosphorylates RAF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-606349", "l": "Mis18 complex binds the centromere (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381612", "l": "GLP1R binds GLP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2214351", "l": "PLK1 phosphorylates GORASP1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75643", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449978", "l": "IL7 binds IL7R:JAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727450", "l": "PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.49", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43928", "l": "pregn-5-ene-3,20-dione = progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120048", "l": "U6 snRNA (adenine-(43)-N(6))-methyltransferase activity", "d": ["Catalysis of the reaction: adenosine in U6 snRNA + S-adenosyl-L-methionine = H+ + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090488", "l": "polo box domain specific binding", "d": ["Binding to a polo box domain of a protein. The polo box domain is involved in binding substrates of polo kinases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29295", "l": "aldehydo-D-galacturonate(out) + H(+)(out) = aldehydo-D-galacturonate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37498", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0070888", "l": "E-box binding", "d": ["Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354097", "l": "Activation of Talin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948063", "l": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59885", "l": "2-oxoglutarate + chloride + H(+) + L-lysine + O2 => 4-chloro-L-lysine + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705926", "l": "AR binds AR agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37412", "l": "aklavinone + NADP(+) => aklaviketone + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48480", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004142", "l": "diacylglycerol cholinephosphotransferase activity", "d": ["Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46794", "l": "an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26364", "l": "L-tyrosine + NADPH + S-adenosyl-L-methionine <=> 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32162", "l": "AH2 + epoxyqueuosine(34) in tRNA <=> A + H2O + queuosine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664214", "l": "ATP2B1 (PMCA1) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9670673", "l": "FIX is secreted (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603534", "l": "Unknown caspase cleaves NTRK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682011", "l": "LC3 binds ATG7 dimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9850958", "l": "pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047672", "l": "anthranilate N-benzoyltransferase activity", "d": ["Catalysis of the reaction: anthranilate + benzoyl-CoA = N-benzoylanthranilate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19732", "l": "acetoacetate + H(+) <=> acetone + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213241", "l": "Formation of nonameric complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9824582", "l": "MAPK1 phosphorylates SOX10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50656", "l": "3-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071837", "l": "HMG box domain binding", "d": ["Binding to an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839358", "l": "Endocytosis of TGFBR3:ARRB complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786190", "l": "CMBL hydrolyses OM to OLMS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334827", "l": "SUMO-CRABP2 binds atRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61830", "l": "H(+) + stigmasteryl 3-beta-D-glucoside + UDP => stigmasterol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13824", "l": "2-oxoglutarate + glutarate + O2 <=> (S)-2-hydroxyglutarate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41893", "l": "(3R)-hydroxytetradecanoyl-[ACP] => (2E)-tetradecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72988", "l": "myo-inositol(out) + 2 Na(+)(out) => myo-inositol(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61671", "l": "ATP + CoA + salicylate <=> 2-hydroxybenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9705584", "l": "HMGCR dimer binds statins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981622", "l": "Myoglobin:oxygen dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474158", "l": "GCHFR binds to GCH1 and negatively regulates its activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.-", "l": "\"With NADH or NADPH as one donor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102256", "l": "neoagarohexaose 1,3-alpha-3,6-anhydro-L-galactosidase activity", "d": ["Catalysis of the reaction: neoagarohexaose + H2O = 3,6-anhydro-alpha-L-galactopyranose + agaropentaose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15027", "l": "7-methylxanthosine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40631", "l": "H2O + trioctadecanoylglycerol = 2,3-dioctadecanoyl-sn-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70009", "l": "2-aminobenzoyl-AMP + diphosphate => anthranilate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446634", "l": "IRAK4 is activated by autophosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75081", "l": "Formation of AT-AC B Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030738", "l": "tyramine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247839", "l": "Retromer associates with WLS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77612", "l": "2 3-tetradecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) => 3-tetradecanoyl-sn-glycero-1-phospho-(3'-tetradecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77608", "l": "Binding of A1CF to stem-looped RNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36668", "l": "(15Z)-tetracosenoyl-CoA + sphinganine => CoA + H(+) + N-(15Z-tetracosenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222259", "l": "PHF20 binds TP53 dimethylated on K370 and K382 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35619", "l": "L-idarate = D-glucarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009554", "l": "IL34 dimer:SDC1 binds CSF1R (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25738", "l": "L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34784", "l": "a 3alpha-hydroxysteroid + NADP(+) => a 3-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015126", "l": "canalicular bile acid transmembrane transporter activity", "d": ["The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010096", "l": "Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47199", "l": "a short-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45545", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62044", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O = (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59455", "l": "a long-chain primary fatty alcohol + NADP(+) <=> a long-chain fatty aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63447", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin <=> GMP + H(+) + oxidized coenzyme F420-0", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74026", "l": "L-alanine(in) + L-serine(out) <=> L-alanine(out) + L-serine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36682", "l": "dTDP-6-deoxy-alpha-D-allose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3323050", "l": "TXNRD2 catalyzes the reduction of TXN2 by NADPH (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-209792", "l": "N-acetylation of serotonin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78938", "l": "a long-chain (3R)-hydroxyacyl-CoA + NAD(+) <=> a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72336", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + syringate => 3-O-methylgallate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688397", "l": "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20722", "l": "CoA + H(+) + L-2-aminoadipate + penicillin G => H2O + isopenicillin N + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30898", "l": "H2O + O2 + propane-1,3-diamine <=> 3-aminopropanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562603", "l": "BfrB stores iron (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63744", "l": "UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan-1-N-beta-D-glucuronide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047043", "l": "3-alpha-hydroxycholanate dehydrogenase activity", "d": ["Catalysis of the reaction: lithocholate + NAD+ = 3-oxo-5beta-cholanate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12085", "l": "D-mannitol + NAD(+) => D-fructose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42978", "l": "2-aminoprop-2-enoate + indole => L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22400", "l": "androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53554", "l": "18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77203", "l": "3'-phosphoadenylyl sulfate + deoxycholate = 3alpha-sulfodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9615249", "l": "ARBs bind AGRT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620891", "l": "FOXO3 binds BTG1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1449687", "l": "Corticosteroids bind to CBG in blood (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64732", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (11S)-hydroperoxy-(4Z,7Z,9E,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59309", "l": "D-galactono-1,5-lactone + H2O => D-galactonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67346", "l": "CoA + kaempferol 7-O-(6-O-malonyl-beta-D-glucoside) => kaempferol 7-O-beta-D-glucoside + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72437", "l": "(E)-caffeoyl-CoA + AMP + H(+) => (E)-caffeoyl-AMP + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60263", "l": "L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050573", "l": "dTDP-4-dehydro-6-deoxyglucose reductase activity", "d": ["Catalysis of the reaction: dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H+ + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61980", "l": "H(+) + NADPH + ubiquinone-10 = NADP(+) + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66479", "l": "gypsogenate + UDP-alpha-D-glucose <=> gypsogenate 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008254", "l": "3'-nucleotidase activity", "d": ["Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3244643", "l": "STING binds cyclic GMP-AMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35721", "l": "(S)-versiconol + acetate + H(+) => (3S)-versiconol acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60907", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> 13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646468", "l": "mTORC1 binds RHEB:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21373", "l": "H(+) + H2O + urethane => CO2 + ethanol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54441", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + H(+) => a 4-H-anthocyanidin with a 3-hydroxy group + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10810", "l": "(1R,2S)-epoxypropylphosphonate + 2 H2O => (S)-2-hydroxypropylphosphonate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047822", "l": "hypotaurine dehydrogenase activity", "d": ["Catalysis of the reaction: H+ + hypotaurine + NADPH + O2 = H2O + NADP+ + taurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3777129", "l": "HDAC3 containing complexes deacetylate histone (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75856", "l": "Abortive Initiation Before Second Transition (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48758", "l": "D-erythrulose + H(+) + NADH => erythritol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626817", "l": "PKC phosphorylates NCF1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43676", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34209", "l": "beta-D-glucose 1-phosphate + L-rhamnopyranose => 3-O-alpha-D-glucosyl-L-rhamnose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44600", "l": "a fatty acid + ATP + H(+) = a fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33488", "l": "(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA => CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70470", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2 <=> a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867876", "l": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611851", "l": "ADRB2 bind ADR,NAd (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35953", "l": "diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate => (7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942224", "l": "Filaggrin binds Keratin tonofilament:Desmosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72100", "l": "Na(+)(out) + O-acetyl-(R)-carnitine(out) => Na(+)(in) + O-acetyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19842", "l": "H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54415", "l": "a 3-oxo-5beta-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50532", "l": "acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13862", "l": "D-xylose + NAD(+) => D-xylono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40034", "l": "ent-copalyl diphosphate + H2O <=> diphosphate + ent-manool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334164", "l": "DNMT3B:DNMT3L binds chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0055100", "l": "adiponectin binding", "d": ["Binding to adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21023", "l": "5-O-(1-carboxyvinyl)-3-phosphoshikimate <=> chorismate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73091", "l": "AMP(out) + FMN(in) = AMP(in) + FMN(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9688459", "l": "RIPK3 binds HSP90:CDC37 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109702", "l": "PDPK1 phosphorylates AKT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374758", "l": "Somatostatin receptors bind somatostatin and cortistatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29002", "l": "H(+)(out) + homoserine lactone(in) <=> H(+)(in) + homoserine lactone(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63412", "l": "2,4,6-trichlorophenol + FADH2 + O2 = 2,6-dichlorobenzoquinone + chloride + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3318415", "l": "ATF2 acetylates histone H2B, H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-202111", "l": "AKT1 phosphorylates eNOS (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56611", "l": "5,10-methylenetetrahydrosulfopterin + glycine + H2O <=> L-serine + tetrahydrosulfopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.103", "l": "\"physarolisin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050314", "l": "sym-norspermidine synthase activity", "d": ["Catalysis of the reaction: 1,3-diaminopropane + S-adenosylmethioninamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56594", "l": "a ketone + hydrogen cyanide => a disubstituted aliphatic (S)-hydroxynitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66523", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37560", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine => 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71828", "l": "arsenate(in) + H(+)(in) => arsenate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9624800", "l": "CDK1 phosphorylates LBR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70810", "l": "4-deoxy-4-sulfo-D-erythrose <=> 4-deoxy-4-sulfo-D-erythrulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12465", "l": "myo-inositol + UDP-alpha-D-galactose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46604", "l": "[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63925", "l": "ATP + N(4)-acetylcytidine => ADP + H(+) + N(4)-acetylcytidine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22529", "l": "a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose => a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75708", "l": "12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate => 10,11-epoxy-12-hydroxy-(14Z,17Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33298", "l": "L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45781", "l": "(9Z)-octadecenoyl-CoA + di-(9Z)-octadecenoylglycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0043176", "l": "amine binding", "d": ["Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120160", "l": "intraciliary transport particle A binding", "d": ["Binding to an intraciliary transport particle A (IFT A) complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29429", "l": "(R)-carnitine(in) + 4-(trimethylamino)butanoate(out) => (R)-carnitine(out) + 4-(trimethylamino)butanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0102175", "l": "3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity", "d": ["Catalysis of the reaction: a 3beta-hydroxysteroid-4alpha-carboxylate + NAD+ = a 3-oxosteroid + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236939", "l": "Interaction of exogenous soluble antigen with its corresponding receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75062", "l": "chloride(out) + 2 hydrogencarbonate(in) + K(+)(in) <=> chloride(in) + 2 hydrogencarbonate(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21866", "l": "a 2-hydroxy carboxylate + glutathione + H(+) => an S-(2-hydroxyacyl)glutathione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033885", "l": "10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity", "d": ["Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28332", "l": "H(+) + IDP + phosphate => H2O + ITP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679041", "l": "ABCC2 transports BMG,BDG from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:1990043", "l": "5' deoxyribonuclease (pyrimidine dimer) activity", "d": ["Catalysis of the endonucleolytic cleavage immediately 5' to pyrimidine dimers to products with 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17520", "l": "H2O + N-(long-chain-fatty-acyl)-L-glutamate <=> a long-chain fatty acid + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3364014", "l": "Recruitment of SET1 methyltransferase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050010", "l": "isovitexin beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: isovitexin + UDP-D-glucose = H+ + isovitexin 2''-O-beta-D-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799097", "l": "ATM phosphorylates ZNF420 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0005153", "l": "interleukin-8 receptor binding", "d": ["Binding to an interleukin-8 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0000268", "l": "peroxisome targeting sequence binding", "d": ["Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046510", "l": "UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity", "d": ["Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76921", "l": "4-methylcyclohexanone + H(+) + NADPH + NH4(+) => 4-methyl-cyclohexylamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983156", "l": "Polyubiquitination of substrate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41565", "l": "aklavinone + dTDP-beta-L-rhodosamine => aclacinomycin T + dTDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806613", "l": "Keratin tetramers bind to form unit length filaments (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32567", "l": "(2E)-geranyl diphosphate = (1R,4S)-camphene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.116", "l": "\"(+)-camphene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0047429", "l": "nucleoside triphosphate diphosphatase activity", "d": ["Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784738", "l": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10671", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) <=> 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27812", "l": "(2Z,6Z)-farnesyl diphosphate + 2 diphosphate => dimethylallyl diphosphate + 2 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0099181", "l": "structural constituent of presynapse", "d": ["The action of a molecule that contributes to the structural integrity of a presynapse."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77371", "l": "[alpha-N-acetylneuraminyl-(2->8)](n)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP-N-acetyl-beta-neuraminate = [alpha-N-acetylneuraminyl-(2->8)](n+1)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21549", "l": "H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin] => acetate + L-lysyl-[alpha-tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15483", "l": "(6S)-5,6,7,8-tetrahydrofolate + L-serine => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671993", "l": "CIT-3 binds DLG4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64483", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate <=> (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68459", "l": "(S)-3-hydroxyglutaryl-CoA <=> (2E)-glutaconyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673789", "l": "Activated JNK phosphorylates c-JUN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57310", "l": "diphosphate + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine => CTP + H(+) + N(5)-phospho-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76620", "l": "(6E)-8-methylnon-6-enoyl-CoA + 4-hydroxy-3-methoxy-benzenemethanol => capsiate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68541", "l": "(2Z,6Z)-farnesyl diphosphate => (-)-alpha-cedrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971487", "l": "CHPF,CHSY3 transfer GalNAc to chondroitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009034", "l": "tryptophanase activity", "d": ["Catalysis of the reaction: L-tryptophan + H2O = indole + NH4 + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61973", "l": "1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549355", "l": "CRY proteins stabilize unphosphorylated BMAL1:CLOCK,NPAS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977071", "l": "ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173115", "l": "Formation of Pre-Integration Complex (PIC) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20641", "l": "H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH", "d": [], "t": []}, {"i": "EC:1.1.1.23", "l": "\"histidinol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11345", "l": "an N-acylneuraminate + CTP => a CMP-N-acyl-beta-neuraminate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6789126", "l": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55006", "l": "3-isopropenyl-6-oxoheptanoate + H2O + NADP(+) => 1-hydroxylimonen-2-one + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390597", "l": "Release Of ADP From Myosin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419049", "l": "ROCK activation by RHO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19660", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) <=> CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47435", "l": "(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55502", "l": "ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta,3beta-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160106", "l": "tRNA (adenine(9)-N1)-methyltransferase activity", "d": ["Catalysis of the reaction: adenosine(9) in tRNA + S-adenosyl-L-methionine = H+ + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928614", "l": "EFNB:GRB4 binds GIT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005147", "l": "oncostatin-M receptor binding", "d": ["Binding to an oncostatin-M receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50636", "l": "a 3-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29315", "l": "alpha-D-galactose 1-phosphate + H2O = D-galactose + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.94", "l": "\"D-galactose 1-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54749", "l": "ATP + CoA + firefly L-luciferin => AMP + diphosphate + L-firefly luciferyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785181", "l": "LMF1,2 bind LIPC dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909732", "l": "Phosphorylation of STAT2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25628", "l": "H2O + histamine + O2 <=> H2O2 + imidazole-4-acetaldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.8", "l": "\"2,6-dioxo-6-phenylhexa-3-enoate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005213", "l": "structural constituent of egg chorion", "d": ["The action of a molecule that contributes to the structural integrity of an egg chorion. An example of this is found in Drosophila melanogaster."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74309", "l": "12alpha-hydroxy-3-oxochola-4-en-24-oate + H(+) + NADH => 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75573", "l": "11-O-acetylcyathin A3 + CoA => acetyl-CoA + cyathin A3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75704", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate => 14,15-epoxy-12-hydroxy-(10E)-eicosenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046574", "l": "glycuronidase activity", "d": ["Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1471314", "l": "HNP1-3 bind CD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097007", "l": "4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity", "d": ["Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = 4,8,12-trimethyl-1,3,7,11-tridecatetraene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C18-farnesylacetone and then cleaved to produce 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT) and acetone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4837364", "l": "Secretion of SOD3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56435", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40998", "l": "3-hydroxy-3-(4-hydroxyphenyl)propanoyl-CoA <=> 4-hydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63608", "l": "apelin-17 + H2O = apelin-16 + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912757", "l": "p-S585-IL3RB binds 14-3-3 proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.66", "l": "\"beta-selinene cyclase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1299338", "l": "Activation of TRESK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700154", "l": "Active ALK binds SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49540", "l": "(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate = (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.61", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71670", "l": "malonate(out) + succinate(in) <=> malonate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11600", "l": "ATP + CMP = ADP + CDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70224", "l": "(2S)-2-aminobutanoate + 2-oxoglutarate => 2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052907", "l": "23S rRNA (adenine(1618)-N(6))-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69505", "l": "N-acetyl-D-glucosamine + O2 => H2O2 + N-acetyl-D-glucosamino-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36616", "l": "2-hydroxyoctadecanoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxyoctadecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578663", "l": "MSH3 variant:MSH2-defective DNA mismatch repair (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3782655", "l": "HDAC10 deacetylates histone (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65154", "l": "(2S)-naringenin 7-O-beta-D-glucoside + H(+) + UDP => (2S)-naringenin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47590", "l": "a ganglioside GQ1c (d18:1(4E)) + CMP + H(+) => a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211882", "l": "CYP3A7 can 6beta-hydroxylate testosterone (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428752", "l": "Dissociation of the TP:Gq complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139909", "l": "Translocation of BMF to mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12715", "l": "a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+) => a nucleoside 5'-phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51947", "l": "8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine <=> 2 H(+) + roseoflavin + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32695", "l": "(2E)-geranyl diphosphate = (-)-car-3-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197958", "l": "FPGS-2 transforms THF to THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50939", "l": "(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate <=> acetoacetyl-CoA + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71164", "l": "HGD dioxygenates homogentisate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.34", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322431", "l": "XIAP binds TLE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70485", "l": "a 2'-deoxyguanosine in single-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in single-stranded DNA + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809140", "l": "IL35 binds IL-12RB2:IL6ST receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801109", "l": "CHM binds RGGT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9854984", "l": "Transfer of Fe-S clusters to SDHB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11088", "l": "H2O + trimetaphosphate = 2 H(+) + triphosphate", "d": [], "t": []}, {"i": "EC:3.6.1.2", "l": "\"trimetaphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64420", "l": "H(+)(out) + L-alanyl-L-proline(out) = H(+)(in) + L-alanyl-L-proline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202212", "l": "Recruitment of PLC-gamma1 to LAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21759", "l": "H2O + N-deacetylisoipecoside <=> dopamine + secologanin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27325", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72232", "l": "chloride(out) + N-methyl-L-proline(out) + 2 Na(+)(out) => chloride(in) + N-methyl-L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67842", "l": "a lipid IVA + ADP + H(+) => a lipid A disaccharide + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65205", "l": "(3R)-3-hydroxybutanoyl-CoA + H2O => (R)-3-hydroxybutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018804", "l": "RAC3 GEFs activate RAC3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392530", "l": "p-S400-Cot phosphorylates NIK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660753", "l": "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27876", "l": "pyruvate + salicylate => isochorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9853499", "l": "DLD dimer dehydrogenates dihydrolipoyl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865276", "l": "PDGF-AB clevage by Furin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823065", "l": "GPIb:IX:V binds to VWF multimer:collagen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196753", "l": "2xPPCS ligates PPanK with Cys (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40810", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76533", "l": "H2O + N-acetyl-L-cysteine + NAD(+) + oxaloacetate => H(+) + N-acetyl-S-(2-succino)-L-cysteine + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5681987", "l": "LC3 is cleaved by ATG4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61627", "l": "2-oxoglutarate + cadaverine <=> 5-aminopentanal + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74346", "l": "O-hexanoyl-(R)-carnitine(in) <=> O-hexanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036311", "l": "chitin disaccharide deacetylase activity", "d": ["Catalysis of the reaction: 2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H2O = 2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990605", "l": "GU repeat RNA binding", "d": ["Binding to an RNA molecule containing GU repeats."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35075", "l": "doxorubicin(in) + H(+)(out) = doxorubicin(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60724", "l": "dodecanal + H2O + NADP(+) = dodecanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714361", "l": "RHOC activates endoplasmic reticulum effectors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65411", "l": "NAD(+)(in) <=> NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14476", "l": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) <=> a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938913", "l": "RUNX1 binds ELF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28849", "l": "Li(+)(out) + melibiose(out) => Li(+)(in) + melibiose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986446", "l": "IL26 binds IL20RA:JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71241", "l": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448632", "l": "IL34 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983148", "l": "Interaction of Erp57 with MHC class I HC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32075", "l": "geranylgeranyl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate", "d": [], "t": []}, {"i": "EC:3.1.7.10", "l": "\"(13E)-labda-7,13-dien-15-ol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73958", "l": "3,4-dihydroxystyrene + H(+) + NADH <=> 4-ethylcatechol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43938", "l": "androst-4-ene-3,17-dione => androst-5-ene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39697", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA + NADP(+) => 3-oxo-(13Z)-eicosenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160874", "l": "HYAL1 hydrolyses (HA)50 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374896", "l": "Uptake of Noradrenaline (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59690", "l": "D-maltoheptaono-1,5-lactone + H2O2 => D-maltoheptaose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51489", "l": "archaetidylserine + H(+) => archaetidylethanolamine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32722", "l": "L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51157", "l": "ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797100", "l": "CCNK binds CDK13 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14075", "l": "4-amino-3-hydroxybutanoate + CO2 => 3-hydroxy-L-glutamate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34146", "l": "cannabinerolate + O2 <=> Delta(9)-tetrahydrocannabinolate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682010", "l": "ATG10:ATG12 binds ATG5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31873", "l": "alpha-seco-amyrin => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018814", "l": "RHOT1 hydrolyzes GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102496", "l": "GA5 2,3 epoxidase activity", "d": ["Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate = gibberellin A6 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983153", "l": "E1 mediated ubiquitin activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9028533", "l": "NR1H2,3, NRIP1 bind the FASN gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78716", "l": "3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + H2O => 3-dehydro-D-glucose + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30762", "l": "5-methylcytosine + H(+) + H2O <=> NH4(+) + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63118", "l": "nitrate => peroxynitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.95", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010503", "l": "HOXA2 binds ROBO2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2309779", "l": "PTGS2 dimer binds PTGS2 inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39168", "l": "H(+) + malonyl-CoA + tetradecanoyl-CoA => 3-oxohexadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203613", "l": "depalmitoylation of eNOS (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50130", "l": "17-oxoresolvin D1 + H(+) + NADH => NAD(+) + resolvin D1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29307", "l": "FMNH2 + methanesulfonate + O2 = FMN + formaldehyde + 2 H(+) + H2O + sulfite", "d": [], "t": []}, {"i": "EC:1.14.14.34", "l": "\"methanesulfonate monooxygenase (FMNH2)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32425", "l": "(R)-carvone + AH2 => (1R,4R)-dihydrocarvone + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75343", "l": "adenosine(in) = adenosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61614", "l": "7-epi-cylindrospermopsin + CO2 + succinate => 2-oxoglutarate + 7-deoxycylindrospermopsin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39489", "l": "(2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76740", "l": "dodecane + O2 + reduced [NADPH--hemoprotein reductase] => 5-dodecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851979", "l": "BTNL9 binds immune cell surfaces (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423038", "l": "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20670", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) => 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39535", "l": "(3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA = (2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160134", "l": "protein-RNA sequence-specific adaptor activity", "d": ["A protein adaptor activity characterized by the capacity to selectively recognize and interact with RNA molecules in a sequence-specific manner. Entities possessing this activity typically exhibit discerning binding preferences for specific nucleotide sequences within RNA molecules, enabling the identification and engagement of distinct RNA motifs or structural elements. This function is integral to various biological processes, including RNA processing, transport, and regulatory mechanisms, contributing to the specificity and precision of cellular RNA-related activities."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2559639", "l": "Collagen type IV sulfilimine cross-linking by peroxidasin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28583", "l": "ATP + dUDP => ADP + dUTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201622", "l": "Caspase-mediated cleavage of gelsolin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.81837140711167", "identifiers": [{"i": "GO:0016661", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.7.-.-", "l": "\"Acting on other nitrogenous compounds as donors\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25801", "l": "H2O + N(1)-acetylspermine + O2 => 3-acetamidopropanal + H2O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218891", "l": "RIPK1:RIPK3 oligomer binds MLKL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34520", "l": "N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + 3 UDP-N-acetyl-alpha-D-galactosamine => [alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + 3 H(+) + 3 UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46046", "l": "(2E)-octenoyl-CoA => (3Z)-octenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39322", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH <=> (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32313", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-tyrosine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71050", "l": "glycine(in) + L-phenylalanine(out) <=> glycine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18835", "l": "4-sulfobenzoate + 2 H(+) + NADH => 4-formylbenzenesulfonate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1474210", "l": "Collagen type III degradation by MMP14 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0051429", "l": "corticotropin-releasing hormone receptor binding", "d": ["Binding to a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853793", "l": "p-5Y-RET complexes bind GRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140858", "l": "histone H2AK15 ubiquitin ligase activity", "d": ["Catalysis of the transfer of a ubiquitin molecule to histone 2A at the lysine-15 residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53392", "l": "2-phenylacetate + O2 + reduced [NADPH--hemoprotein reductase] = (2-hydroxyphenyl)acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.54", "l": "\"phenylacetate 2-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56583", "l": "6-thioguanine + S-adenosyl-L-methionine <=> 6-methylthioguanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.146", "l": "\"beta-galactofuranosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70687", "l": "4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) = 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3204311", "l": "AOX1 oxidises PXL to PDXate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009282", "l": "CDK1 phosphorylates RUNX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814187", "l": "EVL:PPL heterodimer binds the inner surface of the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77094", "l": "Formation of cap binding complex (CBC) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45728", "l": "(E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964759", "l": "Alternative endo-mannosidase I route (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34856", "l": "2 H2O + iminodiacetonitrile => N-(cyanomethyl)glycine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247569", "l": "PADI4 deiminates Histones (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62523", "l": "a cytidine in rRNA + S-adenosyl-L-methionine <=> an N(4)-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77000", "l": "H(+) + NAD(+) + reduced [4Fe-4S]/[3Fe-4S]-[ferredoxin] => NADH + oxidized [4Fe-4S]/[3Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48661", "l": "8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031689", "l": "A3 adenosine receptor binding", "d": ["Binding to an A3 adenosine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2395517", "l": "NADPH transfers electrons to FDXR (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14576", "l": "D-glucarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29764", "l": "ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) => ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48133", "l": "(2E,6E)-farnesyl phosphate + H2O => (2E,6E)-farnesol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018732", "l": "sulfolactone hydrolase activity", "d": ["Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835623", "l": "POU5F1 and SOX2 bind the ZIC1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66679", "l": "(2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide <=> 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63642", "l": "2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10207", "l": "dimethylamine + H(+) + H2O + oxidized [electron-transfer flavoprotein] <=> formaldehyde + methylamine + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617879", "l": "HOXA4 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45699", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(in) <=> N-(acetyl)-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987161", "l": "p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52619", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + ATP <=> 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50105", "l": "taurine + tetradecanoyl-CoA => CoA + H(+) + N-tetradecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37583", "l": "D-lysine + H2O + O2 = 6-amino-2-oxohexanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58171", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-5-epi-eremophilene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9821902", "l": "PSIP1 binds MEN1 associated with MLL2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39756", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12358", "l": "D-fructose 6-phosphate => D-mannose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17380", "l": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] <=> 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68080", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30618", "l": "15-cis-phytoene + 2 A <=> 2 AH2 + all-trans-zeta-carotene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.-", "l": "\"Omega peptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76735", "l": "decane + O2 + reduced [NADPH--hemoprotein reductase] = 3-decanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31277", "l": "(S)-2-methyl-3-oxopropanoate + H(+) + NADH => (S)-3-hydroxy-2-methylpropanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21064", "l": "[protein]-disulfide + 2 glutathione = [protein]-dithiol + glutathione disulfide", "d": [], "t": []}, {"i": "EC:1.8.4.2", "l": "\"protein-disulfide reductase (glutathione)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102067", "l": "geranylgeranyl diphosphate reductase activity", "d": ["Catalysis of the reaction: (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + 3 NADP = 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + 3 NADPH + 3 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54671", "l": "pre-alpha-onocerin <=> alpha-onocerin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9823906", "l": "TBK1 is phosphorylated within the activated TLR4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928641", "l": "PAK binds RAC and bPIX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836059", "l": "Expression of DLX5 in the neural plate border (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70150", "l": "6-deoxo-28-norcastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 28-norcastasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987223", "l": "IL10RB binds TYK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55713", "l": "3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417820", "l": "P2Y9 receptor can bind to LPA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617927", "l": "FOXO4 binds ATXN3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15095", "l": "3-(4-hydroxyphenyl)pyruvate + L-glutamate => 2-oxoglutarate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5632738", "l": "DDIT4 binds 14-3-3 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69360", "l": "bromide + H(+) + H2O2 + L-tyrosyl-[protein] = 3-bromo-L-tyrosyl-[protein] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71252", "l": "L-xylopyranose => L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59440", "l": "(-)-dehydrodiconiferyl alcohol + H(+) + NADPH = (S)-isodihydrodehydrodiconiferyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045550", "l": "geranylgeranyl reductase activity", "d": ["Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61049", "l": "lochnericine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56700", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.11", "l": "\"3-[(Z)-2-isocyanoethenyl]-1H-indole synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51248", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129362", "l": "Fibrillin microfibril assembly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68063", "l": "a 14alpha-methyl steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 14alpha-hydroxymethyl steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53400", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32476", "l": "glycine + 3 S-adenosyl-L-methionine => glycine betaine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24623", "l": "NAD(+) + octan-1-ol <=> H(+) + NADH + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41760", "l": "a ganglioside GM3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.70", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43852", "l": "H(+) + malonyl-CoA + triacontanoyl-CoA = 3-oxo-dotriacontanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34115", "l": "carboxynorspermidine + H2O + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59750", "l": "CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein] => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41134", "l": "1-decanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-decanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73912", "l": "ATP + psilocin => ADP + H(+) + psilocybin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851866", "l": "MET binds RANBP10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69870", "l": "a uridine in RNA + S-adenosyl-L-methionine <=> a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112434", "l": "Formation of DSIF complex  (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30034", "l": "(S)-muconolactone <=> cis,cis-muconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30784", "l": "D-glyceraldehyde + H2O + NAD(+) => (R)-glycerate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65145", "l": "2-oxoglutarate + berkeleyone A + O2 => CO2 + H2O + preaustinoid A + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74969", "l": "a (3R)-3-isocyanyl-fatty acyl-AMP + diphosphate => a (3R)-3-isocyanyl-fatty acid + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.604068309348747", "identifiers": [{"i": "GO:0016769", "l": "transferase activity, transferring nitrogenous groups", "d": ["Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.6.-.-", "l": "\"Transferring nitrogenous groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77823", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-alanine + O2 = (2S)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69140", "l": "N-(4-aminobutyl)-3-aminopropanal = acrolein + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28662", "l": "beta-lactose + H2O <=> beta-D-galactose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932322", "l": "CK2 phosphorylates NFE2L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12104", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP", "d": [], "t": []}, {"i": "EC:2.1.1.45", "l": "\"thymidylate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102613", "l": "trimethyluric acid monooxygenase activity", "d": ["Catalysis of the reaction: 1,3,7-trimethyluric acid + O2 + NADH + 3 H+ = 1,3,7-trimethyl-5-hydroxyisourate + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380949", "l": "AMPK is dephosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62030", "l": "D-glucose + stigmasterol => H2O + stigmasteryl 3-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21666", "l": "4-nitrophenol + H(+) + phosphate => 4-nitrophenyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682718", "l": "nsp15 forms a hexamer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018757", "l": "deisopropylhydroxyatrazine aminohydrolase activity", "d": ["Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004746", "l": "riboflavin synthase activity", "d": ["Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ = 5-amino-6-(D-ribitylamino)uracil + riboflavin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9854405", "l": "Frataxin transfers Fe2+ to ACO2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78679", "l": "Sr(2+)(in) = Sr(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41676", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31344", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69200", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[tubulin] + L-glutamate = ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[tubulin] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30693", "l": "formaldehyde + 2 H2O => H2O2 + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57321", "l": "acetyl-CoA + N-terminal L-(Asp/Glu)3-[protein] => CoA + H(+) + N-terminal N-acetyl-L-(Asp/Glu)3-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48210", "l": "(2E)-nonenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + nonanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419049", "l": "ROCK activation by RHO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20007", "l": "an alcohol + D-glucuronate => an alpha-D-glucuronoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5213466", "l": "RIPK3 is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39086", "l": "3-oxododecanedioyl-CoA + CoA <=> acetyl-CoA + decanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52787", "l": "2-sulfenohercynine + AH2 + H(+) <=> A + ergothioneine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30634", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate <=> beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14329", "l": "2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400143", "l": "Fatty acid ligands activate PPARA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42382", "l": "2 AH2 + all-trans-4,4'-diapolycopene-4,4'-dioate + 2 H(+) => 2 A + all-trans-4,4'-diapolycopene-4,4'-dial + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59783", "l": "L-histidine + S-adenosyl-L-methionine <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60892", "l": "a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O = a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.168", "l": "\"2-dehydropantolactone reductase (Re-specific)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25214", "l": "H2O + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine => 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30221", "l": "dimethyl sulfone + H(+) + NADH => dimethyl sulfoxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52879", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate <=> 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2247513", "l": "STAB1:ligand is endocytosed (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23476", "l": "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O", "d": [], "t": []}, {"i": "EC:4.1.1.48", "l": "\"indole-3-glycerol-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15869", "l": "2-oxoglutarate + D-alanine = D-glutamate + pyruvate", "d": [], "t": []}, {"i": "EC:2.6.1.21", "l": "\"D-amino-acid transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353283", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610802", "l": "GluN3A (GRIN3A), GluN3B (GRIN3B) NMDA receptors traffic to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015369", "l": "calcium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43672", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050180", "l": "phloretin hydrolase activity", "d": ["Catalysis of the reaction: H2O + phloretin = H+ + phloretate + phloroglucinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9609310", "l": "β-blockers bind ADRB1,2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209960", "l": "Diiodinated tyrosine can be deiodinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.44", "l": "\"phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47007", "l": "H2O + O-phospho-L-threonyl-[protein] <=> L-threonyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0004623", "l": "phospholipase A2 activity", "d": ["Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941895", "l": "Formation of CDK4/6:CCND complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047018", "l": "indole-3-acetaldehyde reductase (NADH) activity", "d": ["Catalysis of the reaction: indole-3-ethanol + NAD+ = (indol-3-yl)acetaldehyde + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692237", "l": "ADH5 oxidises S-HMGSH to S-FGSH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-217255", "l": "FMO1:FAD N-oxidises TAM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18707", "l": "a beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191763", "l": "snRNP:Snurportin complex formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24691", "l": "acetate + eugenol + NADP(+) => (E)-coniferyl acetate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57756", "l": "2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112690", "l": "PTPN11 binds CBL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840488", "l": "PSAP(195-273) forms a dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850945", "l": "Casein kinase II phosphorylates PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112514", "l": "JAK activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56482", "l": "(3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (4,5-dibromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183130", "l": "C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203130", "l": "OLR1 binds to oxidized LDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71157", "l": "(E)-caffeate + H(+) + pyruvate => (E)-caffeoylpyruvate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51151", "l": "a primary alcohol + 2 oxidized [azurin] <=> an aldehyde + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662669", "l": "Dopaquinone transforms to Leucodopachrome (Cyclodopa) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168888", "l": "Alpha1-Microglobulin binds heme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10049", "l": "methanethiol + O-acetyl-L-homoserine => acetate + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43990", "l": "(2E,6E)-omega-hydroxy-farnesyl diphosphate + H2O + NADP(+) => (2E,6E)-farnesyl diphosphate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11429", "l": "beta-D-glucose + O2 => D-glucono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807557", "l": "NOX4, NOX5 reduce O2 to O2.- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63030", "l": "(15Z)-tetracosenoate + NH4(+) => (15Z)-tetracosenamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10284", "l": "L-leucine = (3R)-beta-leucine", "d": [], "t": []}, {"i": "EC:5.4.3.7", "l": "\"leucine 2,3-aminomutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78912", "l": "a very-long-chain (3S)-hydroxyacyl-CoA => a very-long-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75832", "l": "5-oxo-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] => 5-oxo-18-hydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12073", "l": "an (S)-2-haloacid + H2O => a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36196", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30251", "l": "2 a ubiquinol + n H(+)(in) + O2 = 2 a ubiquinone + n H(+)(out) + 2 H2O", "d": [], "t": []}, {"i": "EC:7.1.1.3", "l": "\"ubiquinol oxidase (H(+)-transporting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56026", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68615", "l": "Formation of ORC(1-6) complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58122", "l": "3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate => ATP + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508451", "l": "PTK2B is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388830", "l": "PI3K binds ICOS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36172", "l": "a 1-acylglycerone 3-phosphate + a long chain fatty alcohol => 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66271", "l": "CoA + nonanoyl-AMP <=> AMP + H(+) + nonanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.49", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158756", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46622", "l": "(9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26400", "l": "all-trans-zeaxanthin + 2 O2 <=> 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59942", "l": "2-methyloctadecanoate + CoA + H(+) => 2-methyloctadecanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68935", "l": "ATP + H(+) + NADPH + octanoate <=> AMP + diphosphate + NADP(+) + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2660815", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018814", "l": "RHOT1 hydrolyzes GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9620456", "l": "sGC stimulators bind sGC:NO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70510", "l": "LDH tetramer oxidises LACT to PYR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018610", "l": "dibenzofuran 4,4a-dioxygenase activity", "d": ["Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001515", "l": "opioid peptide activity", "d": ["Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42480", "l": "2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1011598", "l": "DOCKs bind to RhoGEFs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21077", "l": "2'-deoxyuridine + 2-oxoglutarate + O2 => CO2 + succinate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41789", "l": "acetyl-CoA + holo-[ACP] => acetyl-[ACP] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706330", "l": "Active FLT3 binds to SOCS6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0005432", "l": "calcium:sodium antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949609", "l": "Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83650", "l": "FasL:Fas binds FADD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848338", "l": "PNPLA4 hydrolyzes TAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53133", "l": "A + a 3-oxo-Delta(4)-steroid => a 3-oxo-Delta(1,4)-steroid + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805650", "l": "MTA2-NuRD complex deacetylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34578", "l": "2 H(+) + O2 + pentalenolactone F + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalenolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71946", "l": "(S)-malate(out) + 3 Na(+)(out) <=> (S)-malate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53659", "l": "(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 <=> (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418662", "l": "Src activation following P2Y purinoceptor activation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018509", "l": "cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity", "d": ["Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031013", "l": "troponin I binding", "d": ["Binding to troponin I, the inhibitory subunit of the troponin complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11955", "l": "3-hydroxypyruvate <=> 2-hydroxy-3-oxopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51705", "l": "S-adenosyl-L-methionine + xanthohumol => 4-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089714", "l": "UDP-N-acetyl-D-mannosamine dehydrogenase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74526", "l": "L-lysine + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysine + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72192", "l": "cholesterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (16S,22S)-dihydroxycholesterol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56352", "l": "4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 = 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33580", "l": "NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate => H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46405", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9858647", "l": "HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.514861039037328", "identifiers": [{"i": "GO:0004396", "l": "hexokinase activity", "d": ["Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20776", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose = myo-inositol + stachyose", "d": [], "t": []}, {"i": "EC:2.4.1.67", "l": "\"galactinol--raffinose galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74131", "l": "malvidin + UDP-alpha-D-galactose = H(+) + malvidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031682", "l": "G-protein gamma-subunit binding", "d": ["Binding to a G-protein gamma subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035539", "l": "8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity", "d": ["Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.514861039037328", "identifiers": [{"i": "GO:0042379", "l": "chemokine receptor binding", "d": ["Binding to a chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70351", "l": "beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O = beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65559", "l": "a globoside GalGb4Cer + H2O <=> an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061634", "l": "alpha-D-xyloside xylohydrolase", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose."], "t": []}, {"i": "EC:3.2.1.177", "l": "\"alpha-D-xyloside xylohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13565", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-glycerol = 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n CMP + n H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.12", "l": "\"teichoic acid poly(glycerol phosphate) polymerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.2", "l": "\"diacylglycerol cholinephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0030332", "l": "cyclin binding", "d": ["Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53825", "l": "NAD(+) + taurochenodeoxycholate => 7-oxotaurolithocholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803890", "l": "SFN dimerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097351", "l": "toxin sequestering activity", "d": ["Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22100", "l": "3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxybenzoate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.5.6", "l": "\"bromoxynil nitrilase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39125", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA => (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964284", "l": "BTK in active Gq-BTK complex is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679775", "l": "COMT binds COMT Inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54231", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine <=> 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37959", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046608", "l": "carotenoid isomerase activity", "d": ["Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21990", "l": "4'''-demalonylsalvianin + CoA => malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.72", "l": "\"Delta(24)-sterol reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863973", "l": "Fusion of ERC and phagosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57551", "l": "(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] <=> [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036237", "l": "acyl-glucuronidase activity", "d": ["Catalysis of the reaction: an acyl-glucuronoside + H2O = an alcohol + D-glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51729", "l": "dihydroxyacetone phosphate + H2O => dihydroxyacetone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34735", "l": "a fatty acyl-CoA + sphinganine = an N-acylsphinganine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947535", "l": "Cyclisation of GTP to precursor Z (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420206", "l": "Phosphorylation of SRC-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033226", "l": "2-aminoethylphosphonate binding", "d": ["Binding to 2-aminoethylphosphonate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000120", "l": "CBLIF binds RCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9615249", "l": "ARBs bind AGRT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678927", "l": "UNC93B1 delivers endosomal full-length TLRs to endolysosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71912", "l": "cholate(out) + 2 Na(+)(out) => cholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848436", "l": "PTK6 phosphorylates CDKN1B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38000", "l": "2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-L-methionine => H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1461993", "l": "pro-HD5 is cleaved by trypsin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158849", "l": "Phenol can form a sulfate conjugate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31678", "l": "NADP(+) + raucaffrinoline <=> H(+) + NADPH + perakine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618392", "l": "miR-26 binds to the 3'UTR of the ARL4C mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17920", "l": "[Glu(-Cys)](n)-Gly + glutathione + H(+) <=> [Glu(-Cys)](n+1)-Gly + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46056", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (11E,13Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53984", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102713", "l": "gibberellin A25 hydroxylase activity", "d": ["Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate(2-) + O2 = gibberellin A46 + succinate(2-) + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781797", "l": "USP19 binds HIF1A,BIRC2,BIRC3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53254", "l": "5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lathosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15231", "l": "diphosphate + GDP-alpha-D-mannose => alpha-D-mannose 1-phosphate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62068", "l": "2-deoxy-D-glucose 6-phosphate + NADP(+) = 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32489", "l": "CMP + 2 H(+) + phosphocholine => CDP-choline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52493", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0051740", "l": "ethylene binding", "d": ["Binding to ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42240", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10895", "l": "(2R,3S)-3-isopropylmalate + NAD(+) <=> (2S)-2-isopropyl-3-oxosuccinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50396", "l": "(2-aminobenzoyl)acetate + H(+) + octanoyl-CoA = 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O", "d": [], "t": []}, {"i": "EC:2.3.1.230", "l": "\"2-heptyl-4(1H)-quinolone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31007", "l": "(S)-2,3-epoxysqualene = beta-amyrin", "d": [], "t": []}, {"i": "EC:5.4.99.39", "l": "\"beta-amyrin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68634", "l": "2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14411", "l": "H(+) + hypotaurine => cysteamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60828", "l": "a 5'-end triphospho-adenosine in mRNA + H2O = a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68953", "l": "isoscopoletin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + scoparone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71628", "l": "phosphate(in) + succinate(out) => phosphate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75867", "l": "5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] = 5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}, {"i": "EC:2.1.1.384", "l": "\"[methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]--tetrahydromethanopterin methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52205", "l": "butachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => butyl formate + H2O + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36411", "l": "7-dehydrocholesterol + hnu = calciol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033959", "l": "deoxyribodipyrimidine endonucleosidase activity", "d": ["Catalysis of the cleavage of the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74712", "l": "Dissociation of IRS-P from insulin receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67275", "l": "1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O <=> 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062083", "l": "HLA-G specific inhibitory MHC class Ib receptor activity", "d": ["Combining with a MHC class Ib molecule of the HLA-G subclass to mediate signaling that inhibits activation of a lymphocyte."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61921", "l": "(2R,4S)-ketoconazole(in) + ATP + H2O => (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034041", "l": "ABC-type sterol transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out)."], "t": []}, {"i": "RHEA:39747", "l": "cholesterol(in) = cholesterol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858752", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.3", "l": "\"bacterial tyrosine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71151", "l": "4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one = (E)-caffeoylpyruvate + CO2 + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10302", "l": "(2R)-3-phospho-glyceroyl phosphate + H(+) + NADH => D-glyceraldehyde 3-phosphate + NAD(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46666", "l": "5beta-dihydrocorticosterone + NADP(+) => corticosterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41801", "l": "acetyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661230", "l": "MT1A binds arsenic (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004067", "l": "asparaginase activity", "d": ["Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211193", "l": "Homodimerization  of DFF40 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202437", "l": "Phosphorylation of CARMA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-432897", "l": "ILK interacts with beta-1 integrin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29525", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+) => alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218820", "l": "Src kinases phosphorylate VAV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419843", "l": "CALCA(83-119) binds CALCR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22953", "l": "O2 + octanedioyl-CoA => (2E)-octenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57829", "l": "dIMP + H2O => 2-deoxy-D-ribose 5-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70962", "l": "D-tyrosine + H2O + O2 <=> 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22299", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate <=> (1R,2R,3R)-prephytoene diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38311", "l": "carminomycin + S-adenosyl-L-methionine = daunorubicin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.292", "l": "\"carminomycin 4-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139855", "l": "P2X1-mediated entry of Ca++ from plasma (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62074", "l": "6-phospho-D-galactono-1,5-lactone + H(+) + NADPH => D-galactose 6-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35134", "l": "H(+)(out) + L-alanyl-L-glutamate(out) <=> H(+)(in) + L-alanyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210700", "l": "KEN dimer represses transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65748", "l": "2-oxoglutarate + dodecyl sulfate + O2 = CO2 + dodecanal + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55975", "l": "acetyl-CoA + ethanol <=> CoA + ethyl acetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174124", "l": "Dephosphorylation of phospho-Cdh1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-398185", "l": "LARG binds plexin B1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20943", "l": "1D-myo-inositol 1,3,4-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54209", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 => 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25988", "l": "(5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71494", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) <=> an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51920", "l": "a quinone + AH2 = A + a quinol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72801", "l": "L-arginine(in) + L-homoarginine(out) => L-arginine(out) + L-homoarginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102972", "l": "gibberellin A12,2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A110-forming)", "d": ["Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 = gibberellin A110 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8944227", "l": "Association of procollagen type XXII (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41899", "l": "(2E)-tetradecenoyl-[ACP] + H(+) + NADPH <=> NADP(+) + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57712", "l": "(E)-sinapaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47520", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH = isolithocholate + NADP(+)", "d": [], "t": []}, {"i": "EC:1.1.1.393", "l": "\"3beta-hydroxycholanate 3-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16110", "l": "ATP + beta-D-fructose 6-phosphate => ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047534", "l": "2-acetolactate mutase activity", "d": ["Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18833", "l": "4-formylbenzenesulfonate + H2O + NAD(+) = 4-sulfobenzoate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.62", "l": "\"4-formylbenzenesulfonate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45977", "l": "3-oxochola-1,4-dien-22-oate + H(+) + NADH + O2 => 9alpha-hydroxy-3-oxochola-1,4-dien-22-oate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944047", "l": "JUN binds the PTEN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43516", "l": "2-carboxy-5-formylfuran + H2O = 2-carboxy-5-(dihydroxymethyl)furan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851436", "l": "CFHR dimers bind C3b (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19601", "l": "H(+) + NADH + O2 + orcinol = 2,3,5-trihydroxytoluene + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.6", "l": "\"orcinol 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27852", "l": "CoA + H(+) + phenylacetylglycine => glycine + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679000", "l": "Ivacaftor binds CFTR G551D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64282", "l": "acetophenone + L-alanine => (S)-1-phenylethylamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34024", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) => (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73537", "l": "CDP(in) + UTP(out) => CDP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853745", "l": "RET binds GFRA1,GFRA3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60187", "l": "ATP + D-glucose(out) + H2O <=> ADP + D-glucose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814088", "l": "SYS1 binds AcM-ARFRP1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66982", "l": "2-methylbutanoate + CoA + H(+) => 2-methylbutanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-175987", "l": "NNMT transfers CH3 from AdoMet to PY (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36333", "l": "diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate => ATP + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37147", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77509", "l": "(2S,3E)-2-hydroxy-4-phenylbut-3-enenitrile => (E)-cinnamaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856718", "l": "HPDL dioxygenates HPPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54943", "l": "(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61029", "l": "itaconate + L-cysteinyl-[protein] => S-(2,3-dicarboxypropyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198818", "l": "SLC2A1,3 transports DeHA from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.055571254292431", "identifiers": [{"i": "GO:0008483", "l": "transaminase activity", "d": ["Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2214324", "l": "Collagen type VII dimerization (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38025", "l": "6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol => gamma-tocotrienol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035950", "l": "Defective B4GALT1 does not transfer Gal to a branch of keratan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53185", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40082", "l": "docosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20698", "l": "H2O2 + O2 => 2 H(+) + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161962", "l": "LTA4 is hydrolysed to 6t-/6t,12epi-LTB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5659781", "l": "BRCA1 forms a heterodimer with BARD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210805", "l": "Removal of miRNA passenger strand (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60397", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) + H2O => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833362", "l": "Expression of WNT9B during nephron development (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51803", "l": "deoxyadlupulone + dimethylallyl diphosphate <=> adlupulone + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323013", "l": "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983700", "l": "SYK binds the activated BCR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43619", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) <=> [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36990", "l": "CMP + phosphate <=> alpha-D-ribose 1,5-bisphosphate + cytosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11872", "l": "corticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.5", "l": "\"corticosterone 18-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690669", "l": "CD22 binds itself to form homo-oligomers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433711", "l": "Cis-homodimerization of nectins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74123", "l": "pelargonidin + UDP-alpha-D-galactose = pelargonidin 3-O-beta-D-galactoside betaine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73770", "l": "cyclo(L-tryptophyl-L-alanyl) + dimethylallyl diphosphate <=> diphosphate + preechinulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.105", "l": "\"2-methylene-furan-3-one reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14521", "l": "(2E)-geraniol + NADP(+) = (2E)-geranial + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.183", "l": "\"geraniol dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49087", "l": "(-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63424", "l": "(2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.68", "l": "\"2-phospho-L-lactate guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864718", "l": "TFAP2A,TFAP2C homodimers:CITED2 binds PITX2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632868", "l": "CDKN1B is phosphorylated in response to estrogen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12932", "l": "2-oxoglutarate + acetyl-CoA + H2O <=> (2R)-homocitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102917", "l": "(S)-reticuline 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: (S)-reticulinium(1+) + S-adenosyl-L-methionine = H+ + laudanine(1+) + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48966", "l": "[thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O => 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56125", "l": "A + all-trans-lycopene + dimethylallyl diphosphate + H2O => AH2 + diphosphate + nonaflavuxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39213", "l": "(2E)-hexacosenoyl-CoA + H2O => (3R)-hydroxyhexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38106", "l": "L-galactonate <=> 2-dehydro-3-deoxy-L-galactonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36975", "l": "AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218804", "l": "p38 MAPK activation by VEGFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42211", "l": "a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + H(+) + NADPH + O2 <=> a (Z)-omega-(methylsulfinyl)-alkyl-glucosinolate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74110", "l": "discoidol + O2 + reduced [NADPH--hemoprotein reductase] <=> acetone + discodiene + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43413", "l": "a D-galactosylceramide + H2O => an N-acyl-sphingoid base + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805943", "l": "S100A1 binds TLR4:LY96 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837392", "l": "Packaging of antigenomic RNA of human respiratory syncytial virus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390674", "l": "ADRB1 bind ADR,NAd (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23154", "l": "a ubiquinol + NAD(+) => a ubiquinone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5672951", "l": "Inactive RAFs bind YWHAB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68443", "l": "beta-cryptoxanthin + O2 <=> (3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420883", "l": "Opsins act as GEFs for G alpha-t (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140536", "l": "nuclear receptor corepressor activity", "d": ["A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28746", "l": "nitrate(in) + nitrite(out) <=> nitrate(out) + nitrite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33510", "l": "sphing-4-enine 1-phosphate <=> (2E)-hexadecenal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691421", "l": "BTK binds BTK inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14978", "l": "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate => 3-carboxy-cis,cis-muconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156682", "l": "PLK1 phosphorylates NUDC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004703", "l": "G protein-coupled receptor kinase activity", "d": ["Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9036307", "l": "GPER:Heterotrimeric G-protein Gs binds ESTG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48850", "l": "13-hydroperoxy-(9Z,11E)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13480", "l": "H2O + L-tryptophan + NADP(+) <=> H(+) + indole-3-pyruvate + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47161", "l": "4beta-methylzymosterol-4alpha-carboxylate + NAD(+) => 3-dehydro-4-methylzymosterol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14698", "l": "(2E,6E)-farnesol + NADP(+) => (2E,6E)-farnesal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2301205", "l": "SETD8 monomethylates histone H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8873946", "l": "OTUD3 deubiquitinates PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22846", "l": "glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781905", "l": "ZRANB1 binds APC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50616", "l": "NADP(+) + nonan-2-one = (3E)-nonen-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186786", "l": "Autophosphorylation of PDGF beta receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607747", "l": "TRAF6 binds MALT1 oligomers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20989", "l": "ATP + 2 H2O => AMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875183", "l": "CBL monoubiquitinates activated MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668398", "l": "CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68611", "l": "Formation of ORC(1-5) complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65585", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] => 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19747", "l": "AH2 + L-thyroxine => 3,3',5-triiodo-L-thyronine + A + H(+) + iodide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42714", "l": "5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(54) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62151", "l": "dGTP + dTMP <=> dGDP + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41860", "l": "(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16216", "l": "3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033925", "l": "mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity", "d": ["Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16916", "l": "a CDP-1,2-diacyl-sn-glycerol + L-serine <=> a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036505", "l": "prosaposin receptor activity", "d": ["Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50095", "l": "a fatty acyl-CoA + taurine <=> an N-fatty acyl-taurine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59120", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) = 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.117", "l": "\"2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11864", "l": "H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine = dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.5.8.2", "l": "\"trimethylamine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371590", "l": "HSP70 binds to HSP40:nascent protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27507", "l": "cocaine + H2O => benzoate + ecgonine methyl ester + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26069", "l": "3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O => CoA + H(+) + phosphinomethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53606", "l": "1-hexadecanoyl-sn-glycerol + phosphate => 1-hexadecanoyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015244", "l": "fluconazole transmembrane transporter activity", "d": ["Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37967", "l": "galactitol + NADP(+) = D-galactose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.135", "l": "\"1-hydroxy-2-naphthoate hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37078", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186771", "l": "RNF111 binds SMAD7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75522", "l": "FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2 <=> (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.49", "l": "\"[pyruvate kinase]-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114560", "l": "Adhesion of integrin alphaIIbbeta3 to fibrin network (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58636", "l": "N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467794", "l": "Resolution of sister chromatids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49409", "l": "[(1->2)-beta-D-mannosyl](n) + phosphate => [(1->2)-beta-D-mannosyl](n-1) + alpha-D-mannose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56630", "l": "chloride + 2 H(+) + maleylacetate => 5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.27", "l": "\"thermolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34886", "l": "ATP + H2O + selenate(out) <=> ADP + H(+) + phosphate + selenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23669", "l": "apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin => AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69800", "l": "D-tryptophanyl-tRNA(Trp) + H2O => D-tryptophan + tRNA(Trp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850777", "l": "SPINK6 binds KLK14 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20575", "l": "calcitriol + H2O + 2 oxidized [adrenodoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51278", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392748", "l": "L1 binds to AP-2 Clathrin complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21598", "l": "2-aminomalonate semialdehyde + H(+) + NADPH => L-serine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45854", "l": "Co(II)-factor IV + S-adenosyl-L-homocysteine => Co(II)-factor III + H(+) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863472", "l": "DAB2 binds LRP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102545", "l": "phosphatidyl phospholipase B activity", "d": ["Catalysis of the reaction: 2 H2O + a phosphatidylcholine = sn-glycero-3-phosphocholine + 2 H+ + 2 a carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693061", "l": "STAMBP binds STAM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166792", "l": "Conversion of C2 into C2a and C2b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39585", "l": "(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+) => (2E,8Z,11Z,14Z,17Z,20Z,23Z)-hexacosaheptaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35215", "l": "H2O + XDP = H(+) + phosphate + XMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54410", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49993", "l": "H(+) + NADH + O2 + propane => H2O + NAD(+) + propan-2-ol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.111", "l": "\"aqualysin 1\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58745", "l": "H2O + N(7)-methyl-GTP => diphosphate + H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65791", "l": "diuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22026", "l": "2 H(+) + NADH + trimethylamine N-oxide => H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74562", "l": "aldosterone <=> aldosterone hemiacetal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204824", "l": "Interaction of Tie2 and Ang4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12208", "l": "4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.56", "l": "\"methylumbelliferyl-acetate deacetylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377186", "l": "Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76217", "l": "2'-deoxyguanosine(out) => 2'-deoxyguanosine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162188", "l": "COQ5 methylates MDMQ10H2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24300", "l": "2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64757", "l": "H2O + S-benzyl-L-cysteine => benzylthiol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001094", "l": "TFIID-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665405", "l": "ERBB2 ECD mutants bind trastuzumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851011", "l": "TRIM27 polyubiquitinates PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052690", "l": "trichloro-p-hydroquinone reductive dehalogenase activity", "d": ["Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52076", "l": "13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30433", "l": "taraxerol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420980", "l": "Activation of Ca permeable AMPA receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52142", "l": "a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+) => a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55416", "l": "biochanin A + UDP-alpha-D-glucose = biochanin A 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51818", "l": "AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in) => ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48686", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + L-lysine => [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030507", "l": "spectrin binding", "d": ["Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69521", "l": "H2O + N-acetyl-D-galactosamino-1,5-lactone => H(+) + N-acetyl-D-galactosaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67564", "l": "3'-phosphoadenylyl sulfate + chenodeoxycholate = adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686088", "l": "CASP3 cleaves GSDMD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31286", "l": "FAD + H(+) + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14988", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015314", "l": "aminotriazole:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9844057", "l": "SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65449", "l": "butanoyl-CoA + ethanol => CoA + ethyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41034", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043957", "l": "acryloyl-CoA reductase (NADPH) activity", "d": ["Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48302", "l": "glycerol + H(+) + prostaglandin F2alpha => H2O + prostaglandin F2alpha 1-glyceryl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55020", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856053", "l": "MITF-M-dependent GPR143 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51757", "l": "a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4,6-diprenylphloroglucinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866851", "l": "CFTR transits to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5675206", "l": "PEA15 binds MAPK monomers and dimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65898", "l": "glycine + H2O + kynurenate => glyoxylate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49136", "l": "H(+) + L-methionyl-[protein] + NADPH + O2 = H2O + L-methionyl-S-oxide-[protein] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53735", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminosalicylate <=> 2-hydroxy-7,8-dihydropteroate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46184", "l": "3-methylbutanoate + ATP + CoA = 3-methylbutanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62697", "l": "O2 + 4 tellimagrandin II => 2 cornusiin E + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78998", "l": "a 3-carboxymethyl-3-hydroxyacyl-[ACP] <=> a 4-carboxy-3-alkylbut-(2E)-enoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874705", "l": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57276", "l": "a 2'-deoxyguanosine in DNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444202", "l": "Receptor FFAR1 binds free fatty acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36206", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389995", "l": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975111", "l": "TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9   (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110011", "l": "Binding of Grb10 to the insulin receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78319", "l": "a III(4)-a-Fuc-Lc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67164", "l": "bromide + FADH2 + melleolide F + O2 = 6'-bromomelleolide F + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33847", "l": "H2O + N-tetracosanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77452", "l": "hydrogen cyanide + piperonal => (2S)-2-(2H-1,3-benzodioxol-5-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655483", "l": "USP1 autocleavage (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796064", "l": "AcK-NFE2L2 binds the NOTCH1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608862", "l": "SCRIB is required for asymmetric membrane localization of VANGL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62410", "l": "1,3,3'-tri-O-methyl-4alpha-mannobiose + H(+) + S-adenosyl-L-homocysteine => 3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853792", "l": "RET tyrosine phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004055", "l": "argininosuccinate synthase activity", "d": ["Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830804", "l": "N-/O-glycan-sG is secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209924", "l": "Dopa is decarboxylated to dopamine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44522", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12548", "l": "2-cis,4-trans-xanthoxin + NAD(+) = 2-cis-(+)-abscisic aldehyde + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.288", "l": "\"xanthoxin dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216082", "l": "Interaction of integrin alphaXbeta2 with fibrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37588", "l": "2-oxoglutarate + D-lysine => 6-amino-2-oxohexanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40828", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76456", "l": "O-atom dealkylation of dextromethorphan (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72512", "l": "(R)-carnitine(out) + 2-oxoglutarate(in) => (R)-carnitine(in) + 2-oxoglutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396370", "l": "VTN binds collagens II, III and V (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047078", "l": "3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity", "d": ["Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0030547", "l": "signaling receptor inhibitor activity", "d": ["Binds to and modulates the activity of a signaling receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75505", "l": "glycocholate(in) + n H(+)(in) => glycocholate(out) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47395", "l": "H2O + hexadecanoate ester <=> an aliphatic alcohol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65986", "l": "lumisterol 3 => hnu + previtamin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67969", "l": "H2O + presqualene diphosphate => H(+) + phosphate + presqualene phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67374", "l": "L-serine + L-threonine => H2O + L-seryl-L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420019", "l": "Claudins create paired strands through homophilic and heterophilic cis and trans interactions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9859163", "l": "DBT transfers BCAA to CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.108", "l": "\"HtrA2 peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.5.2.12", "l": "\"ABC-type L-arabinose transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726580", "l": "PGR binds PGR agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018521", "l": "1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381668", "l": "cAMP activates EPAC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55031", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine <=> an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78398", "l": "bilirubin IXbeta + NADP(+) <=> biliverdin IXbeta + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34674", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17372", "l": "glycyrrhizin + H2O <=> 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67649", "l": "dATP + H2O => 2'-deoxyadenosine + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16173", "l": "(4-hydroxyphenyl)acetaldehyde + dopamine = (S)-norcoclaurine + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.78", "l": "\"(S)-norcoclaurine synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018766", "l": "RHOU binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43958", "l": "H2O + NADP(+) + omega-hydroxy-15-methyl-hexadecanoate => 15-methylhexadecanoate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69134", "l": "5-aminopentanal + H2O2 + NH4(+) => cadaverine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373061", "l": "Receptors CCR3, 4 and 5 bind CCL5 ligand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381496", "l": "Formation of the IGF:IGFBP3:ALS complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205820", "l": "PRMT6 methylates arginine-4 of histone H2A (H2AR3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72621", "l": "methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + salicylate => 2-methoxybenzoate + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77417", "l": "(2S,3E)-2-hydroxypent-3-enenitrile => (2E)-but-2-enal + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430135", "l": "p-SLP-76 binds ADAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21790", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9858752", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63267", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 <=> 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30916", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O => a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43027", "l": "an S-substituted L-cysteine <=> 2-aminoprop-2-enoate + a thiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70435", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in single-stranded DNA + O2 = a 2'-deoxycytidine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77591", "l": "Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36305", "l": "a long-chain primary fatty alcohol + CoA + 2 NADP(+) => a fatty acyl-CoA + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74815", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16818", "l": "6-phospho-D-gluconate + NADP(+) => 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33609", "l": "(9Z)-octadecenoyl-CoA + AMP + diphosphate => (9Z)-octadecenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29551", "l": "H2O + UDP-alpha-D-glucose = alpha-D-galactose 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21693", "l": "CDP-glycerol + H2O => CMP + 2 H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202233", "l": "Inactivation of Lck by Csk (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225960", "l": "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52030", "l": "a jasmonate + an L-alpha-amino acid => a jasmonyl-L-amino acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18662", "l": "H2O + N(5)-[1(S)-1-carboxyethyl]-L-ornithine + NADP(+) => H(+) + L-ornithine + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25184", "l": "acetyl-CoA + putrescine <=> CoA + H(+) + N-acetylputrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70596", "l": "GOT2 dimer deaminates L-Asp (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004947", "l": "bradykinin receptor activity", "d": ["Combining with bradykinin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617816", "l": "RAB3IP stimulates nucleotide exchange on RAB8A  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0061547", "l": "glycogen synthase activity, transferring glucose-1-phosphate", "d": ["Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22172", "l": "beta-D-fructose 6-phosphate + UDP-alpha-D-glucose = H(+) + sucrose 6(F)-phosphate + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.14", "l": "\"sucrose-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43451", "l": "H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] <=> (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51324", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (8R)-hydroperoxy-(9E,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25287", "l": "lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30254", "l": "2 a ubiquinol + n H(+)(in) + O2 <=> 2 a ubiquinone + n H(+)(out) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65878", "l": "1-hydroxy-5alpha-androstan-3,17-dione => 5alpha-androst-1-ene-3,17-dione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015271", "l": "outward rectifier potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65384", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = (N(2),N(2),N(7))-trimethyl-GMP + a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46308", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18219", "l": "an omega-aminoaldehyde + L-glutamate => 2-oxoglutarate + an alkane-alpha,omega-diamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19267", "l": "3-dehydrocarnitine + H(+) + NADH => carnitine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60865", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46033", "l": "H2O2 + tetradecanoate => (2S)-hydroxytetradecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53848", "l": "NAD(+) + taurocholate = 7-oxo-taurodeoxycholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25764", "l": "(2R,3S)-3-methylmalate + NAD(+) => 3-carboxy-2-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21983", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) <=> adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.106", "l": "\"glucose-1,6-bisphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619478", "l": "CAMKK2 phosphorylates AMPK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641205", "l": "RSPO:LGR binds ZNRF3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2559439", "l": "CD14:LPS binds CR3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130731", "l": "Formation of COPII vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35743", "l": "H(+) + NADPH + O2 + versicolorin B = 2 H2O + NADP(+) + versicolorin A", "d": [], "t": []}, {"i": "EC:1.14.19.n5", "l": "\"versicolorin B desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875451", "l": "MET phosphorylates CBL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49012", "l": "aurachin C + H(+) + NADH + O2 = aurachin C epoxide + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67761", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64933", "l": "dGTP + 2 H2O => dGMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66806", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate => ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691131", "l": "CANDI binds CUL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35045", "l": "N-(4-aminobenzoyl)-L-glutamate(out) => N-(4-aminobenzoyl)-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24236", "l": "2 Fe(III)-[cytochrome c] + H2O + trimethylamine = 2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75492", "l": "25-hydroxyvitamin D3 sulfate(out) + n H(+)(out) => 25-hydroxyvitamin D3 sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373717", "l": "DCC interacts with DIP13alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18309", "l": "an N-acyl-D-amino acid + H2O = a carboxylate + a D-alpha-amino acid", "d": [], "t": []}, {"i": "EC:3.5.1.81", "l": "\"N-acyl-D-amino-acid deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70144", "l": "6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => 28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58934", "l": "5 CO2 + 6 CoA + demethylluteothin + 3 H2O + 4 NADP(+) => 4 (S)-methylmalonyl-CoA + 4-nitrobenzoyl-CoA + 8 H(+) + malonyl-CoA + 4 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38294", "l": "(S)-malyl-CoA + H2O <=> (S)-malate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625482", "l": "PTK2 binds activated EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617735", "l": "TXN disrupts FOXO4 complex with EP300 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19607", "l": "a chlorophyllide + H(+) + phytol => a chlorophyll + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44112", "l": "hexadecanoyl-CoA + nonan-1-ol = CoA + nonyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56440", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39908", "l": "2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose => dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696365", "l": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10944", "l": "H2O + psi-UMP = phosphate + pseudouridine", "d": [], "t": []}, {"i": "EC:3.1.3.96", "l": "\"pseudouridine 5'-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38128", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol => 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001071", "l": "maltoheptaose binding", "d": ["Binding to maltoheptaose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.897406625076428", "identifiers": [{"i": "GO:0016413", "l": "O-acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68301", "l": "L-seryl-[protein] + tetradecanoyl-CoA => CoA + O-tetradecanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814734", "l": "CDSN binds the cornified envelope (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64718", "l": "acrolein + H(+) + NADPH => NADP(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47521", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH => isolithocholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.21", "l": "\"catalase peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429955", "l": "CCR4-NOT complex deadenylates mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389848", "l": "TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0048029", "l": "monosaccharide binding", "d": ["Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65613", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676264", "l": "Formation of the SET1B complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44630", "l": "H(+) + L-anticapsin + NADH => L-dihydroanticapsin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73218", "l": "sulfate(out) + thiosulfate(in) <=> sulfate(in) + thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37483", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine = 1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40506", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine <=> N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453339", "l": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22397", "l": "1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 => glycolaldehyde + guaiacol + H2O + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28516", "l": "(R)-carnitinyl-CoA + AMP + diphosphate => (R)-carnitine + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507875", "l": "Aquaporins passively transport urea into cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18783", "l": "acetyl-CoA + CO2 => H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55045", "l": "(3E,5Z)-tetradecadienoyl-CoA + H2O => (3E,5Z)-tetradecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16074", "l": "2,2-dialkylglycine + H(+) + pyruvate => CO2 + dialkyl ketone + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655277", "l": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58843", "l": "cholesterol sulfate + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol 3-sulfate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15319", "l": "2-deoxy-D-glucose + an alcohol => a 2-deoxy-alpha-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9866272", "l": "2Fe-2S is inserted in UQCRFS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3769370", "l": "WIF1 binds WNTs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432148", "l": "Fgr may phosphorylate p38 MAPK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71767", "l": "2 Fe(2+) + H(+) + NADP(+) = 2 Fe(3+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198958", "l": "KIR2DL2/3 interacting with HLA-C group 1 (Cw4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634916", "l": "CDK5 gene expression is stimulated by NPAS4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51781", "l": "4-prenylphlormethylbutanophenone + dimethylallyl diphosphate => deoxyadlupulone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.98.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53705", "l": "2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O => H(+) + prostaglandin E2 + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032402", "l": "Activated NTRK2 binds FRS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031861", "l": "prolactin-releasing peptide receptor binding", "d": ["Binding to a prolactin-releasing peptide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75127", "l": "neopinone = codeinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48440", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol = a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14555", "l": "2-oxoglutarate + cephalosporin C => (7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65616", "l": "A + cholest-4-en-3-one + H2O = 25-hydroxycholest-4-en-3-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682794", "l": "LGI1 binds ADAM22 and ADAM23 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11116", "l": "acetyl-CoA + an alkane-alpha,omega-diamine = an N-acetylalkane-alpha,omega-diamine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334827", "l": "SUMO-CRABP2 binds atRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373047", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15481", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine", "d": [], "t": []}, {"i": "EC:2.1.2.1", "l": "\"glycine hydroxymethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15429", "l": "heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.342", "l": "\"anaerobilin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797653", "l": "DMGDH:FAD oxidatively demethylates DMGLY to SARC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41859", "l": "3-oxodecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxydecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10946", "l": "phosphate + pseudouridine => H2O + psi-UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004017", "l": "adenylate kinase activity", "d": ["Catalysis of the reaction: ATP + AMP = 2 ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296326", "l": "HCAR1 binds LACT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675896", "l": "PI(3,5)P2 transports from the early endosome membrane to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951926", "l": "RUNX1 gene expression is inhibited by RUNX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38443", "l": "a fatty acyl-CoA + a long chain fatty alcohol = a wax ester + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.75", "l": "\"long-chain-alcohol O-fatty-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392752", "l": "Phosphorylation of L1 by CK-II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149519", "l": "MMACHC decyanates CNCbl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37420", "l": "(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64859", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + phomopsene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389941", "l": "SHP-1 and SHP-2 bind pBTLA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46067", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668735", "l": "RAC1:GTP binds NOX3 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1253300", "l": "ERBB4 binds WWP1/ITCH ubiquitin ligases (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24228", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NAD(+) = 4-methylcatechol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60955", "l": "(E)-5-hydroxyferulate + S-adenosyl-L-methionine <=> (E)-sinapate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9626817", "l": "PKC phosphorylates NCF1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31584", "l": "2-oxo-dATP + H2O => 2-oxo-dAMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15349", "l": "L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate", "d": [], "t": []}, {"i": "EC:2.3.1.35", "l": "\"glutamate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26112", "l": "UDP-N-acetyl-alpha-D-glucosamine => H2O + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52056", "l": "12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047490", "l": "pectin lyase activity", "d": ["Catalysis of the reaction: a pectin = an oligosaccharide with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronate end + a pectin. This reaction is the eliminative cleavage of (1->4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their nonreducing ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10344", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.25", "l": "\"plasmalogen synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421831", "l": "trans-Golgi Network Coat Assembly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202164", "l": "Translocation of PDK1 to Plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034003", "l": "vetispiradiene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + vetispiradiene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.242", "l": "\"3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839376", "l": "TGFBR3(784-851) degradation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "45.734963310334322", "identifiers": [{"i": "GO:0016740", "l": "transferase activity", "d": ["Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61644", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine = 2 Fe(III)-[cytochrome b5] + H2O + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24488", "l": "H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-532603", "l": "Nephrin mediated activation of N-WASP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40270", "l": "(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) <=> 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730872", "l": "Activation of Calcineurin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625774", "l": "PKN1:AR complex binds promoters of KLK2 and KLK3 genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199443", "l": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667965", "l": "ANKLE2 binds PP2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50129", "l": "NAD(+) + resolvin D1 => 17-oxoresolvin D1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141341", "l": "SMOX-3 oxidises SPN to SPM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835473", "l": "Expression of GBX2 in the neural plate border (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015382", "l": "sodium:sulfate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018716", "l": "1-phenanthrol glycosyltransferase activity", "d": ["Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24253", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => 2 ADP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166753", "l": "Conversion of C4 into C4a and C4b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187586", "l": "ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69705", "l": "beta-D-galactose + N-hexadecanoylsphing-4-enine => beta-D-galactosyl-(1<->1')-N-hexadecanoylsphingosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50002", "l": "butan-1-ol + H2O + NAD(+) => butane + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41791", "l": "acetyl-CoA + holo-[ACP] <=> acetyl-[ACP] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71330", "l": "chloride(out) + L-threonine(out) + 2 Na(+)(out) <=> chloride(in) + L-threonine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975594", "l": "PLB1 hydrolyses RPALM to atROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161500", "l": "abacavir [extracellular] => abacavir [cytosol] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863804", "l": "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13752", "l": "a ribonucleoside 5'-triphosphate + AMP <=> a ribonucleoside 5'-diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41961", "l": "a ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose => a ganglioside GA1 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20316", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP <=> 1D-myo-inositol hexakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12813", "l": "L-glutamate = D-glutamate", "d": [], "t": []}, {"i": "EC:5.1.1.3", "l": "\"glutamate racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53987", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72964", "l": "acetoacetate(out) + 2 Na(+)(out) => acetoacetate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218847", "l": "PAK2 binds NCK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66015", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + hypobromite + L-methionyl-[collagen] <=> [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68314", "l": "1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate => 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.240", "l": "\"2-polyprenylphenol 6-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75796", "l": "Na(+)(out) + nicotinate(out) => Na(+)(in) + nicotinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162192", "l": "COQ2 ligates all-E-10PrP2 to PHB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23412", "l": "H2O + N-acetylputrescine = acetate + putrescine", "d": [], "t": []}, {"i": "EC:3.5.1.62", "l": "\"acetylputrescine deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65848", "l": "A + a 3-oxo-Delta(1)-steroid + H2O = a steroid 1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68066", "l": "a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3965450", "l": "DAAM1 recruits PFN1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24904", "l": "5'-phosphoguanylyl(3'->5')guanosine + H(+) => 3',3'-c-di-GMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.012360833342299", "identifiers": [{"i": "GO:0042887", "l": "amide transmembrane transporter activity", "d": ["Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102249", "l": "phosphatidylcholine:diacylglycerol cholinephosphotransferase activity", "d": ["Catalysis of the reaction: a phosphatidylcholine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a phosphatidylcholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209924", "l": "Dopa is decarboxylated to dopamine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61756", "l": "stevioside + UDP-alpha-D-glucose = H(+) + rebaudioside A + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202164", "l": "Translocation of PDK1 to Plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13334", "l": "beta-D-fructose 2,6-bisphosphate + H2O => beta-D-fructose 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43567", "l": "4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + L-alanine <=> [5-(aminomethyl)-3-furyl]methyl phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.2", "l": "\"deoxyribonuclease IV\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.9", "l": "\"NADH:ubiquinone reductase (non-electrogenic)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102090", "l": "adrenaline O-methyltransferase activity", "d": ["Catalysis of the reaction: (R)-adrenaline(1+) + S-adenosyl-L-methionine = metanephrine + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781021", "l": "EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40765", "l": "(20S)-ginsenoside Rg1 + L-rhamnopyranose => (20S)-ginsenoside Re + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453337", "l": "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400204", "l": "PPARA binds RXRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809707", "l": "MTMR12 binds MTMR2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58645", "l": "N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine => (9Z,12Z,15Z)-octadecatrienamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400204", "l": "PPARA binds RXRA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58503", "l": "glycine betaine + H(+) + NADH + O2 <=> glyoxylate + H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.47", "l": "\"dapdiamide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103008", "l": "4-chloro-2-methylphenoxyacetate oxygenase activity", "d": ["Catalysis of the reaction: 4-chloro-2-methylphenoxyacetate + 2-oxoglutarate + O2 = 4-chloro-2-methylphenol + 2-oxo monocarboxylic acid anion + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76433", "l": "Na(+)(in) + NH4(+)(out) => Na(+)(out) + NH4(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731924", "l": "EDNRA binds EDNs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9825754", "l": "HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1467466", "l": "ABCA4 mediates atRAL transport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43358", "l": "cholesteryl (9Z,12Z)-octadecadienoate(out) => cholesteryl (9Z,12Z)-octadecadienoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20911", "l": "3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46605", "l": "[HPr protein]-O-phospho-L-serine + H(+) + phosphate => [HPr protein]-L-serine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62581", "l": "ATP + D-cystine(out) + H2O => ADP + D-cystine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.4", "l": "\"type II site-specific deoxyribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021050", "l": "HSBP1 oligomer binds ESRs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805981", "l": "HMGB1 release from cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68001", "l": "1,1-dichloroethene + AH2 => A + chloride + chloroethene + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27740", "l": "2-deoxy-alpha-D-ribose 1-phosphate + guanine => 2'-deoxyguanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42030", "l": "7-oxolithocholate + H(+) + NADH => NAD(+) + ursodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209823", "l": "Tyrosine is hydroxylated to dopa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004445", "l": "inositol-polyphosphate 5-phosphatase activity", "d": ["Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802922", "l": "Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62779", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36085", "l": "1-O-alkyl-sn-glycerol + H(+) + phosphocholine => 1-O-alkyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451858", "l": "YKI binds to HPO homodimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250930", "l": "B-WICH recruits histone acetyltransferases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202510", "l": "Activation of TAK1-TAB2 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33321", "l": "a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50206", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35017", "l": "riboflavin(out) => riboflavin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661425", "l": "BIL:ALB dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797271", "l": "Expression of MAOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24413", "l": "4-(hydroxymethyl)benzenesulfonate + NAD(+) => 4-formylbenzenesulfonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34307", "l": "4-nitrocatechol + NADPH + O2 = 2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21528", "l": "[phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.11", "l": "\"exopolyphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950183", "l": "IL12B binds IL23A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71779", "l": "4-methyl-2-oxopentanoate(out) + H(+)(out) = 4-methyl-2-oxopentanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17236", "l": "L-fucose <=> L-fuculose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.31", "l": "\"mycolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174624", "l": "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53044", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-ribonucleotide in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18071", "l": "D-arginine => L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034701", "l": "tripeptidase activity", "d": ["Catalysis of the hydrolysis of a tripeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36440", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61590", "l": "ADP + amicoumacin A 2-phosphate + H(+) => amicoumacin A + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68143", "l": "2,5-hexanedione + 2 H(+) + 2 NADPH <=> (2R,5R)-hexanediol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68366", "l": "2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+) => 4-CDP-2-C-methyl-D-erythritol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420595", "l": "Necl-2:Nectin 3 trans heterodimer interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45944", "l": "12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948034", "l": "FGR binds LDL:LRP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51776", "l": "4-prenylphlorisobutanophenone + dimethylallyl diphosphate = deoxycohumulone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9709109", "l": "DHFR dimer binds DHFR inhibitors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.183", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57804", "l": "1-chloro-3-nitrobenzene + NADH + O2 = 4-chlorocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18426", "l": "L-quinate + NADP(+) => 3-dehydroquinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015113", "l": "nitrite transmembrane transporter activity", "d": ["Enables the transfer of nitrite (NO2-) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31459", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate", "d": [], "t": []}, {"i": "EC:5.3.99.10", "l": "\"thiazole tautomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814555", "l": "Integrator complex processes the 3' end of snRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102582", "l": "cyanidin 3-O-p-coumaroylglucoside 2-O''-xylosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + UDP-alpha-D-xylose = cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29560", "l": "H2O + UDP-alpha-D-glucuronate => 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11945", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57688", "l": "apo-[corrinoid adenosyltransferase] + cob(II)inamide = cob(II)inamide-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20228", "l": "(E)-caffeate + S-adenosyl-L-methionine <=> (E)-ferulate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10442", "l": "D-gluconate + H(+) => D-glucono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61313", "l": "germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] => germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015533", "l": "shikimate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432712", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59210", "l": "diphosphate + octadecanoyl-AMP => ATP + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49531", "l": "(ethylene terephthalate)(n) + H2O <=> (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52950", "l": "deoxycholoyl-24-O-(beta-D-glucuronate) + UDP => deoxycholate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62062", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102304", "l": "sesquithujene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = 7-epi-sesquithujene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019144", "l": "ADP-sugar diphosphatase activity", "d": ["Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30955", "l": "9,9'-di-cis-zeta-carotene + 2 a quinone = 7,7',9,9'-tetra-cis-lycopene + 2 a quinol", "d": [], "t": []}, {"i": "EC:1.3.5.6", "l": "\"9,9'-di-cis-zeta-carotene desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.50", "l": "\"alpha-N-acetylglucosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75531", "l": "AH2 + N-acetyl-S-hydroxy-L-cysteine = A + H2O + N-acetyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74670", "l": "(6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate <=> (2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65591", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156678", "l": "Activation of Cdc25C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332235", "l": "CBL binds TGFBR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19585", "l": "lithocholate + NAD(+) = 3-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.52", "l": "\"3alpha-hydroxycholanate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66722", "l": "ADP + H(+) + N-[(S)-lactoyl]-L-phenylalanine(out) + phosphate => ATP + H2O + N-[(S)-lactoyl]-L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635428", "l": "FadD26, FadD28 transfer LCFA adenylate ester to Pks5 (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17150", "l": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] => an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14127", "l": "1(F)-alpha-D-galactosylraffinose + sucrose => 2 raffinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37843", "l": "1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14556", "l": "(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate <=> 2-oxoglutarate + cephalosporin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29021", "l": "D-galactose(out) + H(+)(out) => D-galactose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54403", "l": "1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426163", "l": "SREBP1A,2 binds the CYP51A1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75843", "l": "ergothioneine(out) + Na(+)(out) = ergothioneine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29823", "l": "chloride(in) = chloride(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51461", "l": "H2O + N-(9Z-octadecenoyl)-L-glutamate => (9Z)-octadecenoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63586", "l": "2-deoxyecdysone + phosphate => 2-deoxyecdysone 22-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35063", "l": "H2O + pyrazinamide = NH4(+) + pyrazine-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16378", "l": "(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] => biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043544", "l": "lipoamide binding", "d": ["Binding to lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65165", "l": "benzoyl-CoA + hexan-3-ol => CoA + hexan-3-yl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70613", "l": "GOT2 transaminates OA and L-Glu (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265301", "l": "Corticotropin cleavage from POMC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37020", "l": "A + D-serine + H2O => 3-hydroxypyruvate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58592", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-427514", "l": "eNoSC deacetylates histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419011", "l": "Transhomodimerization of Nectins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45491", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70377", "l": "CoA + H(+) + N-dodecanoyl-3-oxosphinganine => 3-oxosphinganine + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865107", "l": "MICAL1 produces NADP+, H2O2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24899", "l": "2 GTP => 3',3'-c-di-GMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41659", "l": "dihydrosanguinarine + NADP(+) <=> NADPH + sanguinarine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043763", "l": "UTP:glucose-1-phosphate uridylyltransferase regulator activity", "d": ["Binds to and modulates the activity of UTP:glucose-1-phosphate uridylyltransferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50256", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39893", "l": "dTDP + H(+) + vancomycin => devancoaminyl-vancomycin + dTDP-beta-L-vancosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483099", "l": "PA translocates from the outer to the inner mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41267", "l": "H2O + N-(15Z-tetracosenoyl)-sphing-4-enine = (15Z)-tetracosenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419281", "l": "MRRF binds 55S ribosome:mRNA:tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.12.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54064", "l": "(2E,6E)-farnesyl diphosphate + H2O = 10-epi-cubebol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.175", "l": "\"10-epi-cubebol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158941", "l": "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730595", "l": "Phosphorylated STAT3 Forms Dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30193", "l": "15,9'-di-cis-phytofluene + plastoquinol-9 => 15-cis-phytoene + plastoquinone-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54843", "l": "H(+) + NADPH + O2 + octan-3-one <=> H2O + NADP(+) + pentyl propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18453", "l": "[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O = [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.5.2.3", "l": "\"ABC-type beta-glucan transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40558", "l": "dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690152", "l": "USP5 cleaves polyubiquitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36252", "l": "(E)-ferulate + ATP + CoA => (E)-feruloyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75849", "l": "SLC25A1 exchanges CIT and MAL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0050780", "l": "dopamine receptor binding", "d": ["Binding to a dopamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76539", "l": "a fatty acyl-CoA + sphinga-(4E,8E)-dienine = an N-acyl-sphinga-4,8-dienine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28086", "l": "2 H2O2 + Reactive Blue 5 = 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate", "d": [], "t": []}, {"i": "EC:1.11.1.19", "l": "\"dye decolorizing peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41211", "l": "(indol-3-yl)acetate + H(+) + NADH + O2 = 2-hydroxy-(1H-indol-3-yl)acetate + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.235", "l": "\"indole-3-acetate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655266", "l": "Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55289", "l": "tetradecan-1-ol + tetradecanoyl-CoA => CoA + tetradecanyl tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59437", "l": "4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein] => 4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20546", "l": "H(+) + L-kynurenine + NADPH + O2 => 3-hydroxy-L-kynurenine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353154", "l": "pyruvate + CO2 + ATP => oxaloacetate + ADP + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58222", "l": "H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide => L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70014", "l": "2-aminobenzoyl-AMP + CoA <=> AMP + anthraniloyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9829060", "l": "F0 gets N-glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15025", "l": "S-adenosyl-L-methionine + xanthosine = 7-methylxanthosine + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.158", "l": "\"7-methylxanthosine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45206", "l": "H2O + methyl-Co(III)-[methanol-specific corrinoid protein] => Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27801", "l": "(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-octaprenyl diphosphate + 5 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047925", "l": "geranoyl-CoA carboxylase activity", "d": ["Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24988", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] = calcitroate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68079", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP <=> a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66988", "l": "4-methylpentanoate + ATP + CoA = 4-methylpentanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46305", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24726", "l": "N-demethylindolmycin + S-adenosyl-L-methionine = H(+) + indolmycin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.328", "l": "\"N-demethylindolmycin N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52655", "l": "lanosterol + S-adenosyl-L-methionine <=> eburicol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210881", "l": "Dimerization of Tie2/Ang1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47733", "l": "cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47477", "l": "(3E)-tetradecenoyl-CoA => (2E)-tetradecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18907", "l": "acetaldehyde + H(+) + phosphate => H2O + phosphonoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703008", "l": "tamatinib-resistant FLT3 mutants don't bind tamatinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40963", "l": "4 2-aminophenol + 3 O2 = 2 2-aminophenoxazin-3-one + 6 H2O", "d": [], "t": []}, {"i": "EC:1.10.3.4", "l": "\"o-aminophenol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031725", "l": "CXCR6 chemokine receptor binding", "d": ["Binding to a CXCR6 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38558", "l": "an all-trans-retinyl ester + H2O <=> a fatty acid + all-trans-retinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109813", "l": "GRB2-1 binds SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374663", "l": "DCC interaction with Ezrin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14439", "l": "6-amino-2-oxohexanoate + H2O2 + NH4(+) => H2O + L-lysine + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53974", "l": "(8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate => (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67949", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160142", "l": "23S rRNA pseudouridine(746) synthase activity", "d": ["Catalysis of the reaction: uridine(746) in 23S rRNA = pseudouridine(746) in 23S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2167942", "l": "Collagen type XIII ectodomain shedding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5683593", "l": "ATG7:ATG3:LC3 dissociates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683964", "l": "ATM phosphorylates EYA1-4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40486", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 5-oxopentanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72672", "l": "The 60S subunit joins the translation initiation complex  (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12450", "l": "(R)-pantoate + beta-alanine => (R)-pantothenate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70460", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2 => a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15537", "l": "(2R)-3-sulfolactate + NADP(+) = 3-sulfopyruvate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.338", "l": "\"(2R)-3-sulfolactate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050438", "l": "2-ethylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxobutanate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662620", "l": "MT3 binds cadmium (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49186", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + CO2 + methanol => chlorophyllide a + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72326", "l": "3 Na(+)(out) + thiosulfate(out) <=> 3 Na(+)(in) + thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53603", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28085", "l": "(2S)-ethylmalonyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34802", "l": "2,3-didehydroadipoyl-CoA + acetyl-CoA <=> 3-oxo-5,6-didehydrosuberyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050036", "l": "L-threonate 3-dehydrogenase activity", "d": ["Catalysis of the reaction: L-threonate + NAD+ = 3-dehydro-L-threonate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102559", "l": "protein-(glutamine-N5) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a [release factor]-L-glutamine = S-adenosyl-L-homocysteine + H+ + a [release factor]-N5-methyl-L-glutamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17173", "l": "glutathionylspermidine + H2O = glutathione + spermidine", "d": [], "t": []}, {"i": "EC:3.5.1.78", "l": "\"glutathionylspermidine amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140774", "l": "NAD-dependent protein depalmitoylase activity", "d": ["Catalysis of the reaction: N6-octadecanoyl-L-lysyl-[protein] + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:70563", "l": "H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1470010", "l": "Dimerization of STATs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9615348", "l": "AGT(34-41) binds to AGTR2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678841", "l": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58703", "l": "FADH2-C4alpha-hydroperoxide + NADPH + rifampicin <=> FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852317", "l": "PLK1 phosphorylates GTSE1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47500", "l": "cholate + NADP(+) = 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047629", "l": "ADP deaminase activity", "d": ["Catalysis of the reaction: ADP + H2O = IDP + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42497", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate => 10-deacetyl-2-debenzoylbaccatin III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17120", "l": "ATP + L-glutamate + methylamine <=> ADP + H(+) + N(5)-methyl-L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23223", "l": "4-chlorobenzoate + ATP + CoA <=> 4-chlorobenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11048", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid = 1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid", "d": [], "t": []}, {"i": "EC:2.3.1.149", "l": "\"platelet-activating factor acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12587", "l": "16alpha-hydroxyprogesterone <=> 16,17-didehydroprogesterone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66799", "l": "miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727819", "l": "TAK1 phosphorylates MKK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215295", "l": "USP7 deubiquitinates MDM2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031788", "l": "motilin receptor binding", "d": ["Binding to a motilin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13198", "l": "H(+) + sulfite + UDP-alpha-D-glucose => H2O + UDP-alpha-D-6-sulfoquinovose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28416", "l": "4-(gamma-L-glutamylamino)butanal + H2O2 + NH4(+) => gamma-L-glutamylputrescine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0106029", "l": "tRNA pseudouridine synthase activity", "d": ["Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5."], "t": []}, {"i": "RHEA:54572", "l": "a uridine in tRNA = a pseudouridine in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78913", "l": "a very-long-chain (2E)-enoyl-CoA + H2O => a very-long-chain (3S)-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67039", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2 <=> (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70375", "l": "3-oxosphinganine + dodecanoyl-CoA = CoA + H(+) + N-dodecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52758", "l": "an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-cysteinylglycine + L-glutamate => an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32155", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:2.4.99.17", "l": "\"S-adenosylmethionine:tRNA ribosyltransferase-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390886", "l": "HRH4 binds Hist (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72236", "l": "2-methyl-2-(methylamino)propanoate(out) + chloride(out) + 2 Na(+)(out) => 2-methyl-2-(methylamino)propanoate(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665697", "l": "ERBB2 TMD/JMD mutants hetrodimerize (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57518", "l": "15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dolabradiene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0047623", "l": "adenosine-phosphate deaminase activity", "d": ["Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP."], "t": []}, {"i": "EC:3.5.4.17", "l": "\"adenosine-phosphate deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727908", "l": "SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PSMC6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1878002", "l": "XYLTs transfer Xyl to core protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60866", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-guanosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696816", "l": "tRNA ligase complex ligates tRNA exons (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852331", "l": "GTSE1 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28071", "l": "(2E,6E)-farnesyl diphosphate + H2O + heme b => diphosphate + Fe(II)-heme o", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2168038", "l": "Collagen type XV restin release (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938076", "l": "CD38 hydrolyses NAD+ to NAM and ADP-ribose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52048", "l": "9-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879562", "l": "SLCO2B1 has a narrow substrate specificity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73583", "l": "CTP(out) + UDP(in) = CTP(in) + UDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70902", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate <=> (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48902", "l": "3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55267", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine <=> di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9686930", "l": "RIPK3 is cleaved by CASP8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610722", "l": "CK1 phosphorylates p-GLI3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34714", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine <=> 15-methylhexadecasphing-4-enine + a fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645535", "l": "ALPK1 phosphorylates TIFA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928612", "l": "KALRN exchanges GTP for GDP on RAC1, activating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29471", "l": "D-ribose 5-phosphate + H2O = D-ribose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21105", "l": "AH2 + cholesterol + O2 => 25-hydroxycholesterol + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74495", "l": "[(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B = yaequinolone C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37844", "l": "1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714483", "l": "RAC2 translocates to the ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62302", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+) => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158468", "l": "SULT1A1 dimer sulfonates PARA to PARA-SO4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169402", "l": "ISGylation of E2 conjugating enzymes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52180", "l": "(E)-(indol-3-yl)acetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13379", "l": "ADP + alpha-D-glucose 1,6-bisphosphate + H(+) => alpha-D-glucose 1-phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.34", "l": "\"acyl-lipid (9+3)-(E)-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44919", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH <=> (3E)-decenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57500", "l": "3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682983", "l": "ATM phosphorylates WHSC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40480", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64089", "l": "acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA => 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755419", "l": "SUMOylation of NR1H4 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64265", "l": "atrochrysone carboxylate + H(+) => atrochrysone + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70426", "l": "an acyl-CoA + H2O <=> a carboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033838", "l": "flavonol-3-O-glucoside glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350745", "l": "Release of Calumenin  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688834", "l": "ATXN3 binds VCP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62057", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35506", "l": "11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27893", "l": "3'-UMP + H2O <=> phosphate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0140587", "l": "chromatin loop anchoring activity", "d": ["Bridging together two DNA loop anchors together, maintaining a chromatin loop."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20879", "l": "(R)-2-benzylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852354", "l": "GTSE1 facilitates proteasome-mediated degradation of TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200652", "l": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399939", "l": "Autophosphorylation of PAK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63343", "l": "ATP + L-amino acyl-L-seryl-[protein] <=> (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20764", "l": "(S)-methylmalonyl-CoA + pyruvate = oxaloacetate + propanoyl-CoA", "d": [], "t": []}, {"i": "EC:2.1.3.1", "l": "\"methylmalonyl-CoA carboxytransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78427", "l": "D-xylose(out) = D-xylose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396401", "l": "NOTCH1 PEST domain mutants bind HES5 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34489", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + dTDP + H(+) => dTDP-beta-L-rhamnose + N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3223200", "l": "Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72883", "l": "2 3-phenylpyruvate + 2 ATP = 2 AMP + 2 diphosphate + H(+) + polyporic acid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53644", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether B + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.163", "l": "\"(+)-corvol ether B synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035595", "l": "N-acetylglucosaminylinositol deacetylase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate. This reaction is the hydrolysis of an acetyl group from N-acetylglucosaminylinositol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31826", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> cubebol + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43325", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28231", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.-", "l": "\"Dipeptide hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35830", "l": "H2O + N(1)-(3-aminopropyl)agmatine <=> spermidine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112342", "l": "Inactivation of MAP2K1 by CDK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683618", "l": "mRNA3 is translated to protein 3a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.352372097681226", "identifiers": [{"i": "GO:0019205", "l": "nucleobase-containing compound kinase activity", "d": ["Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77614", "l": "Deamination at C6 position of adenosine in Editosome (ADAR1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10863", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 <=> 2-(acetamidomethylene)succinate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0070061", "l": "fructose binding", "d": ["Binding to the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30711", "l": "(S)-linalool = beta-myrcene + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.127", "l": "\"linalool dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34026", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10164", "l": "(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate", "d": [], "t": []}, {"i": "EC:4.2.1.11", "l": "\"phosphopyruvate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870469", "l": "RGGT geranylgeranylates RAB proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13730", "l": "FAD => AMP + H(+) + riboflavin cyclic-4',5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9856502", "l": "mito-STARD7 transports Q10 to outer mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675776", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67940", "l": "2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15834", "l": "(S)-4-hydroxymandelate + H(+) + O2 => 4-hydroxybenzaldehyde + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57505", "l": "3-hydroxybutane-1,2,3-tricarboxylate => pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10227", "l": "ATP + pyridoxal <=> ADP + H(+) + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32419", "l": "(1S,2R,4R)-neoisodihydrocarveol + NAD(+) = (1S,4R)-isodihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389862", "l": "Conversion of glyoxylate to oxalate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548884", "l": "UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69491", "l": "O2 + tetradecan-1-ol <=> H2O2 + tetradecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731147", "l": "Syndecan-4 binds PI(4,5)P2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72325", "l": "3 Na(+)(in) + thiosulfate(in) => 3 Na(+)(out) + thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159868", "l": "Furin cleaves pro-factor VII to factor VII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65811", "l": "decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377640", "l": "Autophosphorylation of SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57636", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + ML-236A carboxylate = holo-[2-methylbutanoate polyketide synthase] + mevinic carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66070", "l": "H2O + kynurenate + L-leucine => 4-methyl-2-oxopentanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16853", "l": "N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68359", "l": "H2O + N-acetyl-L-aspartyl-L-glutamate <=> L-glutamate + N-acetyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40253", "l": "10-carboxy-13-deoxydaunorubicin + H(+) + methanol => 4-O-methylrhodomycin D + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54894", "l": "[LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => [LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008587", "l": "IL37, IL37(?-218) binds IL18BP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35450", "l": "(1'S)-averantin + NADP(+) <=> H(+) + NADPH + norsolorinic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112436", "l": "Formation of Elongin complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22111", "l": "L-threonine <=> 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62307", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine <=> (+)-premalbrancheamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39683", "l": "3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH = (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174444", "l": "Formation of C-strand Okazaki fragments (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987084", "l": "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10777", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) => 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37542", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45107", "l": "6-demethylmitomycin A + S-adenosyl-L-methionine <=> mitomycin A + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008260", "l": "succinyl-CoA:3-oxo-acid CoA-transferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40833", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061667", "l": "URM1 ligase activity", "d": ["Catalysis of the transfer of URM1 to a substrate protein via the reaction X-URM1 + S = X + S-URM1, where X is either an E2 or E3 enzyme, the X-URM1 linkage is a thioester bond, and the S-URM1 linkage is an isopeptide bond between the C-terminal amino acid of URM1 and the epsilon-amino group of lysine residues in the substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28131", "l": "baicalin + H2O => baicalein + D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62300", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449117", "l": "TXLNA (IL14) binds syntaxin1A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76497", "l": "CoA + H(+) + N-acetyl-D-glutamate => acetyl-CoA + D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322431", "l": "XIAP binds TLE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203130", "l": "OLR1 binds to oxidized LDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59738", "l": "CoA + S-tetradecanoyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47054", "l": "alpha-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014293", "l": "RAC2 GDIs block activation of RAC2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848110", "l": "SOCS3 binds activated PTK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.42", "l": "\"homomethionine N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977363", "l": "Factor H binds to C3bBb (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28023", "l": "ATP + holo-[ACP] + octanoate => AMP + diphosphate + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63159", "l": "H2O + N-docosanoyl-taurine <=> docosanoate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46381", "l": "7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24578", "l": "H(+) + 2 phosphate => diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68563", "l": "arsenate + D-glyceraldehyde 3-phosphate + NAD(+) <=> 1-arsono-3-phospho-D-glycerate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23894", "l": "3-nitroacrylate + H(+) + NADPH => 3-nitropropanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014456", "l": "GDIs block activation of RHOG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25641", "l": "(1R,4S)-menthone + NADP(+) = (R)-pulegone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033793", "l": "aureusidin synthase activity", "d": ["Catalysis of the reactions: 2',4,4',6'-tetrahydroxychalcone + O2 = aureusidin + H2O, and 2',3,4,4',6'-pentahydroxychalcone + 1/2 O2 = aureusidin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48315", "l": "benzoyl-CoA + H(+) + NADPH + O2 <=> 2,3-epoxy-2,3-dihydrobenzoyl-CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112434", "l": "Formation of DSIF complex  (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.116", "l": "\"averantin hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26101", "l": "(2R)-homocitrate = cis-homoaconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981892", "l": "Active G alpha (z) binds RGS proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030955", "l": "potassium ion binding", "d": ["Binding to a potassium ion (K+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5649856", "l": "Oxidative damage to the AP site (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1678843", "l": "ISGylation of protein translation regulator 4EHP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196773", "l": "COASY phosphorylates DP-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33009", "l": "(+)-artemisinic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-artemisinic alcohol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44730", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.571199156962493", "identifiers": [{"i": "GO:0016837", "l": "carbon-oxygen lyase activity, acting on polysaccharides", "d": ["Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide."], "t": []}, {"i": "EC:4.2.2.-", "l": "\"Acting on polysaccharides\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975040", "l": "KRAB-ZNF / KAP Interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34616", "l": "2-hydroxyethylphosphonate + O2 => H(+) + hydrogencarbonate + methylphosphonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63653", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30338", "l": "CTP + H(+) + H2O <=> NH4(+) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951486", "l": "CD46 binds C4b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2404134", "l": "RBP4:atROL binds TTR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247836", "l": "Retromer recycles WLS to the Golgi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047170", "l": "glucarate O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: D-glucarate + sinapoyl-CoA = 2-O-sinapoyl-D-glucarate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109862", "l": "MAP2K2 phosphorylates MAPK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425965", "l": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000335", "l": "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635839", "l": "ULK3:SUFU dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190258", "l": "FGFR2c binds to FGF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45219", "l": "coenzyme M + methyl-Co(III)-[dimethylamine-specific corrinoid protein] <=> Co(I)-[dimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59833", "l": "ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38412", "l": "1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O => (9Z,12Z,15Z)-octadecatrienoate + 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015135", "l": "glucuronate transmembrane transporter activity", "d": ["Enables the transfer of glucuronate from one side of a membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44361", "l": "(2S)-2-hydroxy-3,4-dioxopentyl phosphate => 3-hydroxy-2,4-dioxopentyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004936", "l": "alpha-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50576", "l": "acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114306", "l": "SMAC binds XIAP:Caspase-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31186", "l": "acetyl-CoA + decanoyl-CoA <=> 3-oxododecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9861616", "l": "DLD dimer dehydrogenates dihydrolipoyl (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937767", "l": "PTPN11 dephosphorylates RUNX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69068", "l": "RFC dissociates after sliding clamp formation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683888", "l": "LMCD1 binds GATA6, sequestering it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67739", "l": "N-acetyl-alpha-neuraminate <=> aceneuramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74499", "l": "H(+) + NADPH + yaequinolone D = H2O + NADP(+) + penigequinolone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17918", "l": "[Glu(-Cys)](n)-Gly + glutathione + H(+) => [Glu(-Cys)](n+1)-Gly + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65672", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(34-hydroxytetratriacontenoyl)-sphing-4-enine = a diacylglycerol + an N-(34-(9Z,12Z-octadecadienoyloxy)-tetratriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42278", "l": "(4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA => (2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050639", "l": "10-hydroxytaxane O-acetyltransferase activity", "d": ["Catalysis of the reaction: 10-desacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75439", "l": "eburicol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 14-demethyleburicol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27561", "l": "all-trans-hexaprenyl diphosphate + 3 diphosphate => (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836435", "l": "p-PKR dimer phosphorylates SNCA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3769383", "l": "CBY1 binds beta-catenin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71818", "l": "3,3',5'-triiodo-L-thyronine(out) <=> 3,3',5'-triiodo-L-thyronine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27624", "l": "7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate => geranylgeranyl diphosphate + 7 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38075", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65287", "l": "3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate <=> 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110437", "l": "DILP binds to Drosophila insulin receptor (DINR) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61258", "l": "2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+) => H2O + L-cysteine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.57", "l": "\"O-sialoglycoprotein endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46935", "l": "2-epi-5-epi-valiolone 7-phosphate <=> 5-epi-valiolone 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106250", "l": "DNA-binding transcription repressor activity, RNA polymerase III-specific", "d": ["A DNA-binding transcription factor activity that represses or decreases the transcription of specific genes sets transcribed by RNA polymerase III."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74224", "l": "H2O + L-seryl-tRNA(Ala) => L-serine + tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15391", "l": "3',5'-cyclic AMP + diphosphate => ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451900", "l": "IL2RB binds JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710106", "l": "ELANE cleaves GSDMD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48767", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) <=> 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76928", "l": "3-aminopentane + H2O + NADP(+) => H(+) + NADPH + NH4(+) + pentan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77744", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol => a 1-acyl-sn-glycero-3-phosphocholine + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66319", "l": "an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O <=> alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32496", "l": "(2E)-geraniol + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-hydroxygeraniol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604752", "l": "Initial activation of proMMP13 by MMP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42329", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66708", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47461", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + CoA => (3Z)-dodecenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205649", "l": "p62 links damaged mitochondria to LC3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33585", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate => L-glutamate + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22925", "l": "dCMP + H(+) + H2O => dUMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35461", "l": "cholest-5-en-3-one + H(+) + NADH => cholesterol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36627", "l": "2-hydroxytetracosanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018594", "l": "MECP2 binds LBR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70029", "l": "H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine => N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.244991688848543", "identifiers": [{"i": "GO:0043178", "l": "alcohol binding", "d": ["Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210282", "l": "Interaction of GPVI and FceRI gamma (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41007", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin = 6-linalyl-2-O,3-dimethylflaviolin + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.124", "l": "\"6-linalyl-2-O,3-dimethylflaviolin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57618", "l": "dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase] => dihydro-ML-236C-[compactin nonaketide synthase] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031176", "l": "endo-1,4-beta-xylanase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37331", "l": "H2O + L-methionyl-L-alanine = L-alanine + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061608", "l": "nuclear import signal receptor activity", "d": ["Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432401", "l": "JET binds cytosolic TIM, facilitating its ubiquitination (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102299", "l": "linolenate 9R-lipoxygenase activity", "d": ["Catalysis of the reaction: alpha-linolenate + O2 = (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13821", "l": "2-oxoglutarate + glutarate + O2 = (S)-2-hydroxyglutarate + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.64", "l": "\"glutarate dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49248", "l": "galactitol(out) + N(pros)-phospho-L-histidyl-[protein] = galactitol 1-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.200", "l": "\"protein-N(pi)-phosphohistidine--galactitol phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12840", "l": "ATP + choline <=> ADP + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17337", "l": "catechol + O2 = (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.2", "l": "\"catechol 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033924", "l": "dextran 1,6-alpha-isomaltotriosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141118", "l": "nitric oxide dioxygenase activity, heme protein as donor", "d": ["Catalysis of the reaction: Fe(II)-heme b-[protein] + nitric oxide + O2 = Fe(III)-heme b-[protein] + nitrate."], "t": []}, {"i": "RHEA:78091", "l": "Fe(II)-heme b-[protein] + nitric oxide + O2 = Fe(III)-heme b-[protein] + nitrate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949703", "l": "SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31049", "l": "CO2 + NADH + propanoyl-CoA => (S)-2-methyl-3-oxopropanoate + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029476", "l": "Role of myosins in phagosome formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016966", "l": "nitric oxide reductase activity", "d": ["Catalysis of the reaction: H2O + 2 ferricytochrome c + nitrous oxide = 2 H+ + 2 ferrocytochrome c + 2 nitric oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73793", "l": "diphosphate + variecolorin G => dimethylallyl diphosphate + neoechinulin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20243", "l": "N-methylnicotinate + S-adenosyl-L-homocysteine => nicotinate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17636", "l": "a beta-D-glucuronoside + H2O <=> an alcohol + D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193812", "l": "Efflux of 27-hydroxycholesterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615910", "l": "SUMOylation of PCNA with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1454916", "l": "The ABCC family mediates organic anion transport (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811479", "l": "ING2 recruits EP300 to TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46943", "l": "AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein] <=> ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57628", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate = H2O + ML-236C carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57365", "l": "H2O + NADH => (6S)-NADHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69649", "l": "beta-D-glucose + quercetin => H2O + quercetin 4'-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12929", "l": "2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.14", "l": "\"homocitrate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68123", "l": "a 1,2-diacylglycerol + a fatty acyl-CoA <=> a triacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33486", "l": "an acyl-CoA + ergosterol <=> CoA + ergosteryl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209903", "l": "Noradrenaline is converted to adrenaline (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40203", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 14-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114254", "l": "CYCS binds to APAF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44867", "l": "a triacyl-sn-glycerol + H2O <=> a 1,2-diacylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77687", "l": "a ganglioside GD1a (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GalNAc-GD1a (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43810", "l": "1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75103", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 32-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75110", "l": "32-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757456", "l": "2,5-DHBA translocates from ER lumen to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9640195", "l": "RRAGA,B hydrolyzes GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63579", "l": "ecdysone 22-phosphate + H2O <=> ecdysone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801456", "l": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31413", "l": "a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66306", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-alpha-mannosylinositol-1-phosphoceramide => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-mannosylinositol-1-phosphoceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610720", "l": "PKA phosphorylates GLI3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047843", "l": "dehydrogluconate dehydrogenase activity", "d": ["Catalysis of the reaction: 2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354077", "l": "Integrin alphaIIb beta3 activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37243", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004502", "l": "kynurenine 3-monooxygenase activity", "d": ["Catalysis of the reaction: L-kynurenine + H+ + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14808", "l": "ATP + D-allose <=> ADP + D-allose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25504", "l": "(2E)-geranyl diphosphate = beta-phellandrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070406", "l": "glutamine binding", "d": ["Binding to glutamine, 2,5-diamino-5-oxopentanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2453833", "l": "RPE65 isomero-hydrolyses atREs to 11cROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030350", "l": "iron-responsive element binding", "d": ["Binding to an iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:1990190", "l": "peptide-glutamate-alpha-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976742", "l": "NOTCH2 coactivator complex binds FCER2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683774", "l": "p-T68-CHEK2 dimerizes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11018", "l": "(S)-ureidoglycolate + urea => allantoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102261", "l": "8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity", "d": ["Catalysis of the reaction: NADP + a reduced coenzyme F420 = NADPH + H+ + an oxidized coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362522", "l": "ALDHs oxidise atRAL to atRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66113", "l": "2-oxobutanoate + L-tyrosine => (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395340", "l": "Formation of hydroxyallysine by LOX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58395", "l": "4-amino-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 4-amino-5-hydroxy-3-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110319", "l": "Elongation by POLH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32264", "l": "4-aminobutanoate + pyruvate => L-alanine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34270", "l": "acetyl-CoA + fumigaclavine B <=> CoA + fumigaclavine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12304", "l": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) = 2 H(+) + L-2-aminoadipate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60874", "l": "a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methyl-GDP => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60163", "l": "ATP + H2O + vincristine(in) <=> ADP + H(+) + phosphate + vincristine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39376", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA => (2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15290", "l": "[(1->4)-beta-D-xylan](n) + UDP-alpha-D-xylose => [(1->4)-beta-D-xylan](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42156", "l": "androsterone + H(+) + NADPH = 5alpha-androstane-3alpha,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25923", "l": "A + H2O + quinolin-7-ol <=> 7-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614369", "l": "Transport of HCMV DNA Into the Nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033520", "l": "TYSND1 cleaves TYSND1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624949", "l": "Assembly of the anterograde IFT train (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944246", "l": "Association of procollagen type XXI (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47874", "l": "a ganglioside GA1 + N-acetylneuraminate => a ganglioside GM1 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5339535", "l": "CPTP transports C1P from plasma membrane to Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71181", "l": "FAH cleaves 4FAA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42543", "l": "uridine(13) in tRNA <=> pseudouridine(13) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22706", "l": "4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+) => 2 H2O + ricinine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31497", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70646", "l": "D-proline(out) + H(+)(out) <=> D-proline(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2243942", "l": "PDPK1 phosphorylates AKT1 E17K mutant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193981", "l": "CYP21A2 oxidises 17HPROG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972956", "l": "POU5F1 (OCT4), SOX2, NANOG bind the STAT3 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17384", "l": "(9Z,12Z)-octadecadienoate <=> (9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55804", "l": "(R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(2'-(9Z-octadecenoyl)-3'-sn-glycerol) + H2O = (9Z)-octadecenoate + (R,R)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(3'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10189", "l": "acetoacetyl-CoA + acetyl-CoA + H2O => (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947535", "l": "Cyclisation of GTP to precursor Z (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70596", "l": "GOT2 dimer deaminates L-Asp (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877879", "l": "RUNX1 and FOXP3 bind the RSPO3 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804383", "l": "PRMT5 methylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55762", "l": "an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP] => a fatty acyl-[ACP] + a lyso-ornithine lipid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2396029", "l": "Latent TGF-beta-3 binds integrins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0042083", "l": "5,10-methylenetetrahydrofolate-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39682", "l": "(11Z)-octadecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1471322", "l": "Beta-defensins are secreted (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71149", "l": "4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one => 3-hydroxyhispidin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670418", "l": "Phosphorylation of JAK2 downstream of KIT mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21335", "l": "acetyl-CoA + D-glucosamine <=> CoA + H(+) + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18257", "l": "coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX", "d": [], "t": []}, {"i": "EC:1.3.3.3", "l": "\"coproporphyrinogen oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33184", "l": "citrate(in) => citrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33870", "l": "(S)-2-ureidoglycine + glyoxylate <=> glycine + N-carbamoyl-2-oxoglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12262", "l": "ADP + H(+) + NADPH => ATP + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70286", "l": "H2O + N-acetylputrescine + O2 <=> 4-acetamidobutanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22145", "l": "cis-aconitate + H2O => D-threo-isocitrate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65464", "l": "2-methylbutan-1-ol + butanoyl-CoA = 2-methylbutyl butanoate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50053", "l": "ATP + H2O + taurocholate(in) => ADP + H(+) + phosphate + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937097", "l": "MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61975", "l": "1-O-(13-methyltetradecyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-O-(1Z-13-methyltetradecenyl)-2-(13-methyltetradecanoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693061", "l": "STAMBP binds STAM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59084", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613490", "l": "Unwinding of DNA for the nascent HIV-1 transcript: Second Transition (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23800", "l": "H2O + L-methionine = 2-oxobutanoate + methanethiol + NH4(+)", "d": [], "t": []}, {"i": "EC:4.4.1.11", "l": "\"methionine gamma-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109862", "l": "MAP2K2 phosphorylates MAPK1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38283", "l": "itaconate + succinyl-CoA = itaconyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975873", "l": "IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43064", "l": "(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate = holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate", "d": [], "t": []}, {"i": "EC:2.3.1.238", "l": "\"monacolin J acid methylbutanoate transferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762333", "l": "ANGPTL4 binds to CDH11v (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.134", "l": "\"beta-amyrin 24-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46462", "l": "(22R,7alpha)-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (22R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22735", "l": "4-hydroxyphenylacetate + H(+) <=> 4-methylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703895", "l": "CASR binds CASR agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31877", "l": "marneral => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624798", "l": "LBR binds KPNB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14786", "l": "RNA(n) + UTP => diphosphate + RNA(n)-3'-uridine ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44051", "l": "8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> 8,9-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26012", "l": "3,7-dideoxy-D-threo-hepto-2,6-diuolosonate + H(+) + NADH + NH4(+) => 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54487", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphocholine <=> 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28475", "l": "D-glucarate(in) + H(+)(in) => D-glucarate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669855", "l": "Dasatinib-resistant KIT mutants do not bind dasatinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68805", "l": "H2O + kojibiose => alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42928", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.199", "l": "\"16S rRNA (cytosine(1402)-N(4))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33894", "l": "chanoclavine-I + NAD(+) <=> chanoclavine-I aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18418", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GM3 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47717", "l": "4-pregnen-20,21-diol-3-one + NAD(+) => 21-hydroxyprogesterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23286", "l": "dimethylallyl diphosphate => isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676133", "l": "CD74 binds MIF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55189", "l": "5-methyluridine(54) in tRNA + ATP + hydrogen sulfide => 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001586", "l": "Gi/o-coupled serotonin receptor activity", "d": ["Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858428", "l": "FCAMR binds IgA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65734", "l": "CO2 + H(+) + heptanal + succinate + sulfate => 2-oxoglutarate + heptyl sulfate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166362", "l": "Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71773", "l": "2 Cu(2+) + NADPH => 2 Cu(+) + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252001", "l": "ATP1B4 binds SNW1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37139", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57042", "l": "D-apiofuranose => aldehydo-D-apiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67056", "l": "chermesin D + S-adenosyl-L-methionine = chermesin D methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9861725", "l": "PGAM5 dodecamer dephosphorylates p-S336-ME1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76802", "l": "(2S)-2-aminobutan-1-ol + H2O + NAD(+) <=> 1-hydroxy-2-butanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64383", "l": "3 A + phytyl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48427", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dUMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73268", "l": "H(+)(out) + L-methionine(in) => H(+)(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57210", "l": "S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] => glyoxal + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44944", "l": "1-O-alkyl-3-acyl-sn-glycerol + H2O = 1-O-alkyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428696", "l": "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196929", "l": "FLAD1 phosphorylates FMN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982645", "l": "GRKs bind ADRB2:Catecholamine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75073", "l": "chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out) => chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.367", "l": "\"UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114354", "l": "SMAC binds XIAP:Caspase-7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625101", "l": "FOXO1 and SIN3A:HDAC complex bind GCK gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75856", "l": "Abortive Initiation Before Second Transition (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60891", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine-phospho-ribonucleoside in mRNA + H2O <=> (N(7)-methyl 5'-triphospho-guanosine)-guanosine + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24265", "l": "D-xylulose 5-phosphate + formaldehyde => D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57861", "l": "(E)-6-hydroxyferuloyl-CoA => CoA + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70609", "l": "4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 4-ethylphenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38907", "l": "(R)-reticuline + S-adenosyl-L-methionine = (R)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16150", "l": "beta-nicotinamide D-ribonucleotide + diphosphate => 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51046", "l": "CO2 + NH4(+) + protodeoxyviolaceinate => indole-3-pyruvate imine dimer", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50187", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8858428", "l": "FCAMR binds IgA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417890", "l": "P2Y5 receptor can bind to LPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.2", "l": "\"dynein ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65871", "l": "Delta(1)-dihydrotestosterone + H2O <=> 1,17beta-dihydroxyandrostan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067659", "l": "Assembly of hexameric IL-6 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11508", "l": "2-oxoglutarate + L-aspartyl-[protein] + O2 = 3-hydroxy-L-aspartyl-[protein] + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.16", "l": "\"peptide-aspartate beta-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51646", "l": "7-dehydrocholesterol + 2 H2O + NAD(+) => cholesterol + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854408", "l": "APOBR dimer binds VLDLs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74230", "l": "H2O + L-threonyl-tRNA(Ile) <=> L-threonine + tRNA(Ile)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66097", "l": "3-phenylpyruvate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009016", "l": "succinyldiaminopimelate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34545", "l": "H(+) + N-acetyl-alpha-D-galactosaminyl-(1->4)-N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,heptacis-undecaprenyl diphosphate + UDP => N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74201", "l": "(2Z)-2-[(3,4-dioxocyclohexa-1,5-dien-1-yl)methylidene]-4-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-olate + H2O => aspulvinone E + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0018551", "l": "dissimilatory sulfite reductase activity", "d": ["Catalysis of the reactions: [DsrC protein]-trisulfide + 3 H2O + NAD+ = [DsrC protein]-dithiol + 3 H+ + NADH + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77220", "l": "a dolichyl beta-D-mannosyl phosphate + L-tryptophyl-[protein] => a dolichyl phosphate + C-alpha-D-mannosyl-L-tryptophyl-[protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62618", "l": "a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+) => a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806831", "l": "CYB5Rs reduce MetHb to HbA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389762", "l": "Phosphorylation of PD-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57403", "l": "3-O-acetylpapaveroxine + H2O <=> acetate + H(+) + narcotine hemiacetal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669870", "l": "Regorafenib-resistant KIT mutants do not bind regorafenib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112396", "l": "Separation of elongating transcript from template (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23323", "l": "D-tryptophan + malonyl-CoA <=> CoA + H(+) + N(2)-malonyl-D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17327", "l": "(S)-2-succinylamino-6-oxoheptanedioate + CoA => (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621606", "l": "CD209 binds ManLAM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40826", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654623", "l": "Activated FGFR3 binds FRS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46492", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3076905", "l": "Extracellular BTD hydrolyses BCTN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9824999", "l": "GSK3B phosphorylates p-S73 MITF-M at residue S69 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810643", "l": "EPPIN protein complex binds bacteria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67589", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O => a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0052617", "l": "ent-kaur-16-en-19-al oxidase activity", "d": ["Catalysis of the reaction: NADPH + ent-kaur-16-en-19-al + oxygen = H2O + NADP+ + ent-kaurenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8858500", "l": "CLEC10A binds Tn-MUC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35649", "l": "3',3'-cGAMP + 2 diphosphate => ATP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9037761", "l": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61471", "l": "a cytidine in tRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11023", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618725", "l": "SOX10, EGR2 and NAB proteins bind the GJB1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72771", "l": "7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27555", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 2 isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + 2 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.82", "l": "\"hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218845", "l": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65275", "l": "chrodrimanin C + H(+) + NADPH + O2 <=> chrodrimanin H + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9757256", "l": "MCM3 binds MCM5 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59017", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) => CO2 + cycloeucalenone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193997", "l": "CYP11B1 oxidises 11DCORT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754129", "l": "CDK6 inhibitors bind CDK6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41397", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine => 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928656", "l": "gamma-secretase cleaves EPHB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-178218", "l": "SMAD7:SMURF complex binds to phosphorylated TGFBR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63059", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine <=> 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25723", "l": "L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75282", "l": "an omega-methyl-medium-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> an omega-hydroxy-medium-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016286", "l": "small conductance calcium-activated potassium channel activity", "d": ["Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814298", "l": "Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5658430", "l": "NF1 is degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3858482", "l": "DVL is recruited to the receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665748", "l": "FMNL2 binds RHOC:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032770", "l": "Translocation of YAP1 to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848864", "l": "PTK6 binds ARAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603784", "l": "PEX19:class I PMP binds PEX3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77081", "l": "H(+) + pre-flavunoidine => 2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane carbocation + N,N-dimethyl-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964773", "l": "OXGR1 binds 2OG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41431", "l": "L-tyrosine + S-adenosyl-L-methionine <=> 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72560", "l": "estrone 3-sulfate(out) + pentanoate(in) => estrone 3-sulfate(in) + pentanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047875", "l": "ecdysone oxidase activity", "d": ["Catalysis of the reaction: Ecdysone + O2 = 3-dehydroecdysone + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696491", "l": "CNTF binds CNTFR complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008447", "l": "L-ascorbate oxidase activity", "d": ["Catalysis of the reaction: 4 L-ascorbate + O2 = 4 monodehydroascorbate + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41856", "l": "3-oxodecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033771", "l": "flavanone 2-hydroxylase activity", "d": ["Catalysis of the reaction: a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 2-hydroxyflavanone + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54686", "l": "(-)-kolavenyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61790", "l": "AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19672", "l": "GTP + H2O <=> GDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-377640", "l": "Autophosphorylation of SRC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39561", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190877", "l": "Insertion of connexons into the plasma membrane resulting in the formation of hemi-channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55555", "l": "N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66831", "l": "2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein] <=> 2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102313", "l": "1,8-cineole synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate(3-) + H2O = 1,8-cineole + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32385", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH => (1S,2S,4R)-limonene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0005353", "l": "fructose transmembrane transporter activity", "d": ["Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey."], "t": []}, {"i": "REACT:R-HSA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607342", "l": "Expression of FABP6 regulated by NR1H2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64747", "l": "H2O + S-3-(hexan-1-ol)-L-cysteine <=> 3-sulfanyl-1-hexanol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30460", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol => (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0090580", "l": "phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands", "d": ["Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551727", "l": "CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36883", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13181", "l": "ATP + H2O + nitrate(out) = ADP + H(+) + nitrate(in) + phosphate", "d": [], "t": []}, {"i": "EC:7.3.2.4", "l": "\"ABC-type nitrate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31522", "l": "O2 + torulene <=> 3-methyl-2-butenal + 4'-apo-beta-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45426", "l": "(9Z)-octadecenoate + H(+) + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72421", "l": "(E)-4-coumaroyl-AMP + diphosphate => (E)-4-coumarate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40149", "l": "CoA + eicosanoate + H(+) => eicosanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.34", "l": "\"neutrophil collagenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30370", "l": "adenosylcob(III)alamin 5'-phosphate + H2O <=> adenosylcob(III)alamin + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031801", "l": "type 4 metabotropic glutamate receptor binding", "d": ["Binding to a type 4 metabotropic glutamate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40240", "l": "ATP + CoA + dodecanedioate => AMP + diphosphate + dodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39759", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158354", "l": "kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796368", "l": "RIPK1 binds STUB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216222", "l": "COS binds to SMO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.10", "l": "\"tripeptidyl-peptidase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55082", "l": "ADP + H(+) + sucrose => ADP-alpha-D-glucose + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19480", "l": "4-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39676", "l": "(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11412", "l": "6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.6.3", "l": "\"2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981892", "l": "Active G alpha (z) binds RGS proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033998", "l": "inulin fructotransferase (DFA-III-forming) activity", "d": ["Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60215", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856808", "l": "Recruitment of AP-2 complex and clathrin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74314", "l": "12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603986", "l": "FUT3 transfers Fuc to Type 1 chains to form LeA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604763", "l": "Autocatalytic activation of MMP7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60706", "l": "a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621571", "l": "CD209 binds ICAM2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30593", "l": "(4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+) => H2O + O2 + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59484", "l": "arsenite + 2 Fe(III)-[cytochrome c] + H2O = arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": [], "t": []}, {"i": "EC:1.20.2.1", "l": "\"arsenate reductase (cytochrome c)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912734", "l": "CBL:CRKL binds RAPGEF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17485", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198955", "l": "TCR complex interacts with peptide antigen-presenting MHC Class I (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56272", "l": "4 Fe(III)-[cytochrome cL] + H2O + methanol = 4 Fe(II)-[cytochrome cL] + formate + 5 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57391", "l": "(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102920", "l": "acyl coenzyme A: isopenicillin N acyltransferase activity", "d": ["Catalysis of the reaction: octanoyl-CoA + isopenicillin N + H2O = H+ + coenzyme A + penicillin K + L-2-aminoadipate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010943", "l": "NADPH pyrophosphatase activity", "d": ["Catalysis of the reaction: NADPH + H2O = NMNH + ADP."], "t": []}, {"i": "RHEA:60820", "l": "H2O + NADPH = adenosine 2',5'-bisphosphate + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69741", "l": "3-phenylsuccinyl-CoA + succinate => phenylsuccinate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.107", "l": "\"apo-salmochelin esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21151", "l": "indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose <=> 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-182986", "l": "CBL-mediated ubiquitination of CIN85 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191654", "l": "c-src associates with Cx43 in gap junctions (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51491", "l": "archaetidylserine + H(+) <=> archaetidylethanolamine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31060", "l": "H2O + imidazole-4-acetaldehyde + NAD(+) => 2 H(+) + imidazole-4-acetate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47914", "l": "2-dehydro-3,6-dideoxy-6-sulfo-D-gluconate + H2O => 6-deoxy-6-sulfo-D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33688", "l": "3'-N-debenzoyltaxol + benzoyl-CoA => CoA + H(+) + taxol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61779", "l": "rebaudioside D + UDP-alpha-D-glucose <=> H(+) + rebaudioside M + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196753", "l": "2xPPCS ligates PPanK with Cys (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28525", "l": "D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O <=> D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110360", "l": "Recruitment of POLB to the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28868", "l": "H(+)(in) + lactose(in) => H(+)(out) + lactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12734", "l": "CO2 + diphosphate + nicotinate beta-D-ribonucleotide => 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70982", "l": "4-aminobutanoate(out) + n H(+)(in) <=> 4-aminobutanoate(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25902", "l": "beta-D-fructose 6-phosphate => D-arabino-hex-3-ulose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218838", "l": "PXN binds p-6Y,S732-PTK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191303", "l": "FDPS dimer transfers IPPP to GPP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38652", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47193", "l": "coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] => Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034821", "l": "citronellol dehydrogenase activity", "d": ["Catalysis of the reaction: citronellol + NAD+ = citronellal + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429683", "l": "CERT1-2 releases its bound ceramide into the membrane of the Golgi apparatus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61399", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050170", "l": "peptidyl-glutaminase activity", "d": ["Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29350", "l": "2 H(+)(in) + orotate(in) <=> 2 H(+)(out) + orotate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44785", "l": "2-demethylmenaquinol-10 + S-adenosyl-L-methionine => H(+) + menaquinol-10 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035599", "l": "aspartic acid methylthiotransferase activity", "d": ["Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008043", "l": "MAPK8 phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008822", "l": "PPM1D dephosphorylates RUNX2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48303", "l": "H2O + prostaglandin F2alpha 1-glyceryl ester <=> glycerol + H(+) + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676926", "l": "Methionine sulfoxide is oxidised to methionine sulfone (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53777", "l": "3-sulfanylpropanoate + O2 => 3-sulfinopropanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0000009", "l": "alpha-1,6-mannosyltransferase activity", "d": ["Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage."], "t": []}, {"i": "REACT:R-HSA-449718", "l": "Addition of a third mannose to the N-glycan precursor by ALG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000016", "l": "lactase activity", "d": ["Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28573", "l": "ATP + L-serine <=> diphosphate + L-seryl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34162", "l": "acetyl-CoA + UDP-N-acetylbacillosamine <=> CoA + H(+) + UDP-N,N'-diacetylbacillosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78909", "l": "a short-chain 3-oxoacyl-CoA + CoA => a short-chain fatty acyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66683", "l": "ATP + coproporphyrinogen III(in) + H2O <=> ADP + coproporphyrinogen III(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31614", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene <=> H2O + rhodopin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71670", "l": "PKM dephosphorylates PEP to PYR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50770", "l": "anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine => 4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665280", "l": "ERBB2 KD mutants do not bind osimertinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70994", "l": "SDH complex dehydrogenates succinate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3782637", "l": "HDAC8 deacetylates histones (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27846", "l": "(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679205", "l": "ULK1 phosphorylates Beclin-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49070", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin] => 25-hydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47928", "l": "(2S)-3-sulfolactaldehyde + H2O + NADP(+) = (2S)-3-sulfolactate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627106", "l": "SMAC (DIABLO) forms dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42794", "l": "cholesteryl hexadecanoate + CoA => cholesterol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192054", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48481", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose => 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047965", "l": "glycoprotein O-fatty-acyltransferase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672980", "l": "Dissociation of RAS:RAF complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009817", "l": "Acitretin binds to RAR:RXR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177930", "l": "GAB1 phosphorylation by EGFR kinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15386", "l": "L-asparagine => 3-cyano-L-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41880", "l": "(2E)-dodecenoyl-[ACP] + H(+) + NADPH = dodecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433711", "l": "Cis-homodimerization of nectins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43276", "l": "a ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GalNAc-GD1a + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29821", "l": "ADP + H(+) + L-isoleucine(in) + phosphate => ATP + H2O + L-isoleucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75894", "l": "holothin + pseudomonoyl-CoA C <=> CoA + pseudomonic acid C--holothin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47602", "l": "a ganglioside GM4 (d18:1(4E)) + CMP + H(+) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839368", "l": "TGFBR3(1-783) binds to TGFB1,TGFB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52658", "l": "a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH => a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483089", "l": "PE is converted to PS by PTDSS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170026", "l": "UCP1 imports a proton (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769394", "l": "AKT phosphorylates CBY1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75513", "l": "CoA + H(+) + N-acetyl-S-benzyl-L-cysteine => acetyl-CoA + S-benzyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019705", "l": "protein-cysteine S-myristoyltransferase activity", "d": ["Catalysis of the transfer of a myristoyl (systematic name, tetradecanoyl) group to a sulfur atom on a cysteine residue of a protein molecule in the reaction: tetradecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-tetradecanoyl-L-cysteinyl-[protein]."], "t": []}, {"i": "RHEA:59736", "l": "L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S-tetradecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71005", "l": "L-histidine(out) + L-phenylalanine(in) => L-histidine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59865", "l": "(indol-3-yl)butanoate + ATP + L-glutamine => (indol-3-yl)butanoyl-L-glutamine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-947531", "l": "Molybdenum ion transfer onto molybdopterin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950637", "l": "Expression of cell division cycle 42 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55636", "l": "ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75293", "l": "glyoxylate(out) + oxalate(in) => glyoxylate(in) + oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53343", "l": "5,6-dihydrouridine(20) in tRNA + NAD(+) <=> H(+) + NADH + uridine(20) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69259", "l": "H2O + progoitrin <=> (Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30262", "l": "2 a menaquinol + n H(+)(in) + O2 <=> 2 a menaquinone + n H(+)(out) + 2 H2O(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061607", "l": "peptide alpha-N-propionyltransferase activity", "d": ["Catalysis of the reaction: propionyl-CoA + peptide = CoA + N-alpha-propionylpeptide. This reaction is the propionylation of the N-terminal amino acid residue of a peptide or protein."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177671", "l": "Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78476", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine => a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687090", "l": "p-S MAPK6 phosphorylates NCOA3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.2.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428690", "l": "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018755", "l": "2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity", "d": ["Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31760", "l": "dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10956", "l": "(E)-cinnamate + H(+) + NADPH + O2 = H2O + NADP(+) + trans-2-coumarate", "d": [], "t": []}, {"i": "EC:1.14.13.14", "l": "\"trans-cinnamate 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17672", "l": "3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74447", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67145", "l": "2-oxoglutarate + jasmonate + O2 => (1R,2R)-12-hydroxyjasmonate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709454", "l": "EPOR binds EPOR agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37849", "l": "daunorubicin + 2 H2O + NADP(+) => 13-dihydrodaunorubicin + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15338", "l": "H2O + phenylglyoxylyl-CoA => CoA + H(+) + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20006", "l": "an alpha-D-glucuronoside + H2O => an alcohol + D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.10", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48943", "l": "an L-aminoacyl-L-amino acid + H2O <=> 2 an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390846", "l": "D2D3,4 bind to DA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61998", "l": "CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein] => L-lysyl-[protein] + lactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45330", "l": "7,8-dihydromonapterin => 7,8-dihydroneopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.13", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625091", "l": "FOXO1,FOXO3 bind ABCA6 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68228", "l": "glycine(in) + Na(+)(in) = glycine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39890", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592387", "l": "Fibulin binds elastic fibres (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46937", "l": "(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) => ATP + H(+) + L-2-aminoadipate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32602", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> 3-isopropenyl-6-oxoheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48781", "l": "ATP + L-erythrulose => ADP + H(+) + L-erythrulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69637", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30007", "l": "ATP + H2O + L-arabinose(out) = ADP + H(+) + L-arabinose(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11396", "l": "5-methyldeoxycytidine 5'-phosphate + ATP = 5-methyldeoxycytidine diphosphate + ADP", "d": [], "t": []}, {"i": "EC:2.7.4.19", "l": "\"5-methyldeoxycytidine-5'-phosphate kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33574", "l": "A + methanol <=> AH2 + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53075", "l": "2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate <=> 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76809", "l": "(3S)-1-hydroxy-3-methylpentan-2-one + H(+) + NADH + NH4(+) => (S)-isoleucinol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9639287", "l": "SESN1,2 binds L-leucine and dissociates from GATOR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008860", "l": "ferredoxin-NAD+ reductase activity", "d": ["Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28062", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0034593", "l": "phosphatidylinositol bisphosphate phosphatase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50250", "l": "ADP-D-ribose + diphosphate => ATP + D-ribose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004592", "l": "pantoate-beta-alanine ligase activity", "d": ["Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60276", "l": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.355", "l": "\"[histone H3]-lysine(9) N-trimethyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69636", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954398", "l": "PLD6 dimer hydrolyses cardiolipin to PA and PG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37165", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9750666", "l": "ALB binds ST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37366", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 <=> 5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28666", "l": "H2O + melibiose <=> D-galactose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14787", "l": "diphosphate + RNA(n)-3'-uridine ribonucleotide => RNA(n) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793057", "l": "NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67535", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9861725", "l": "PGAM5 dodecamer dephosphorylates p-S336-ME1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37200", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69241", "l": "glucoraphanin + H2O => (Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48074", "l": "a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate => a ganglioside GM1 (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140064", "l": "peptide crotonyltransferase activity", "d": ["Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide."], "t": []}, {"i": "RHEA:53908", "l": "(2E)-butenoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65820", "l": "decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37191", "l": "2',3'-cyclophospho-AMP + H2O = adenosine 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:1901235", "l": "(R)-carnitine transmembrane transporter activity", "d": ["Enables the transfer of (R)-carnitine from one side of a membrane to the other."], "t": []}, {"i": "RHEA:34959", "l": "(R)-carnitine(in) = (R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45094", "l": "octanoate + sphing-4-enine => H2O + N-octanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4649028", "l": "TLE forms non-functional complexes with AES (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44188", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005176", "l": "ErbB-2 class receptor binding", "d": ["Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32279", "l": "allantoate + 2 H(+) + 2 H2O = (S)-ureidoglycolate + CO2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668735", "l": "RAC1:GTP binds NOX3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57979", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose <=> (20S)-ginsenoside C-K + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2995330", "l": "COX10 transforms heme to heme O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57245", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-dGTP => dGTP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687115", "l": "MYC positively regulates MAPKAPK5 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46495", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2534096", "l": "METAP1/2 demethylates GNAT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56366", "l": "carminomycin + 2 H2O + NADP(+) => 13-dihydrocarminomycin + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:1990760", "l": "osmolarity-sensing monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798489", "l": "S100A7 or S100A7A binds Zn2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53497", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050215", "l": "propanediol dehydratase activity", "d": ["Catalysis of the reaction: propane-1,2-diol = H2O + propanal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182990", "l": "Sprouty sequesters CBL away from active EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69006", "l": "AMP + cremeomycin + diphosphate + H2O => 3-amino-2-hydroxy-4-methoxybenzoate + ATP + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.124", "l": "\"3-deoxy-2-octulosonidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9704297", "l": "CHRM2 binds CHRM2 antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622604", "l": "BCL2L11 gene expression is stimulated by FOXO1,FOXO3,(FOXO4) and NF-Y (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948136", "l": "ULK1 Translocates to the mitochondria (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654510", "l": "FGFRL1 binds SPRED1/2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354066", "l": "Translocation of PTK2 to Focal complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042944", "l": "D-alanine transmembrane transporter activity", "d": ["Enables the transfer of D-alanine from one side of a membrane to the other. D-alanine is the D-enantiomer of 2-aminopropanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730847", "l": "Hydrolysis of PIP2 by PLCG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64276", "l": "chrysophanol-9-anthrone + O2 = chrysophanol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5340124", "l": "CSN polymer binds CaPO4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41543", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine <=> 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48959", "l": "[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide <=> [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37244", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68092", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA = a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27501", "l": "3',5'-di-O-methyltricetin + S-adenosyl-L-methionine = 3',4',5'-O-trimethyltricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60644", "l": "3'-phosphoadenylyl sulfate + androsterone = adenosine 3',5'-bisphosphate + androsterone 3alpha-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41350", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42589", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048040", "l": "UDP-glucuronate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = CO2 + UDP-alpha-D-xylose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31544", "l": "all-trans-zeaxanthin + 2 UDP-alpha-D-glucose => 2 H(+) + 2 UDP + zeaxanthin bis(beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33933", "l": "(3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal => all-trans-zeaxanthin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983518", "l": "IL35 binds IL6ST:IL6ST receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34396", "l": "L-phenylalanine => L-beta-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54734", "l": "H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662473", "l": "KGPDC decarboxylates 3-dehydro-L-gulonate to L-xylulose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417820", "l": "P2Y9 receptor can bind to LPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614544", "l": "Sulfite is oxidized to sulfate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70481", "l": "TPI1 isomerizes GA3P to DHAP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211983", "l": "CYP2J2 oxidises ARA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17577", "l": "ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose", "d": [], "t": []}, {"i": "EC:5.1.3.20", "l": "\"ADP-glyceromanno-heptose 6-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708558", "l": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44460", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol = a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42663", "l": "NAD(+) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + NADH + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27826", "l": "hydrogen sulfide + O-succinyl-L-homoserine = L-homocysteine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76781", "l": "1,6-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78893", "l": "6-O-methyl-N-deacetylisoipecoside aglycone + D-glucose => 6-O-methyl-N-deacetylisoipecoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48113", "l": "N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine => H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249378", "l": "STING recruits TBK1 and STAT6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69776", "l": "(2E,6E)-farnesyl diphosphate => beta-ylangene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831107", "l": "Nascent SH localizes to Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61958", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O => 1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035248", "l": "alpha-1,4-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676020", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46047", "l": "(3Z)-octenoyl-CoA <=> (2E)-octenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31754", "l": "chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11674", "l": "4-amino-4-deoxychorismate + L-glutamate => chorismate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12590", "l": "a ganglioside GM2 (d18:1(4E)) + H(+) + UDP => a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.148", "l": "\"lycopaoctaene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784189", "l": "JAKs bind LIFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78859", "l": "a short-chain 2,3-saturated fatty acyl-CoA + O2 = a short-chain (2E)-enoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64656", "l": "(E)-sinapaldehyde + CoA + NADP(+) = (E)-sinapoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035401", "l": "histone H3Y41 kinase activity", "d": ["Catalysis of the reaction: histone H3-tyrosine (position 41) + ATP = histone H3-phosphotyrosine (position 41) + ADP. This reaction is the addition of a phosphate group to the tyrosine residue at position 41 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51990", "l": "18S-resolvin E1 => (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58005", "l": "(20S)-ginsenoside F2 + UDP-alpha-D-glucose => (20S)-ginsenoside Rd + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44130", "l": "CoA + hexadecanyl (9E)-octadecenoate => (9E)-octadecenoyl-CoA + hexadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52670", "l": "[amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH => [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71731", "l": "citrate(out) + tartrate(in) = citrate(in) + tartrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870461", "l": "RABGGTA and RABGGTB bind (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42577", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O => 2-methylpropanoate + 2-oxopent-4-enoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32116", "l": "2-oxoglutarate + DIBOA beta-D-glucoside + O2 => CO2 + succinate + TRIBOA beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45032", "l": "4 Fe(III)-[cytochrome c] + H2O + hydroxylamine = 4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite", "d": [], "t": []}, {"i": "EC:1.7.2.6", "l": "\"hydroxylamine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658496", "l": "SIAH1:UBE2L6:Ubiquitin binds SNCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71576", "l": "5-phosphomethyl-dUMP in DNA + putrescine => 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420980", "l": "Activation of Ca permeable AMPA receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44986", "l": "CoA + O-3-methylbutanoyl-(R)-carnitine => (R)-carnitine + 3-methylbutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983266", "l": "Kinesins bind microtubules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70602", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37545", "l": "2-amino-5-chloromuconate 6-semialdehyde => 2-amino-5-chlorophenol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837835", "l": "SH pentamer transports K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25918", "l": "6-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-6-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21928", "l": "3-dehydro-L-gulonate + NADP(+) = 2,3-dioxo-L-gulonate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38493", "l": "(9Z)-octadecenoate + glycerol + H(+) => 2-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57225", "l": "glyoxal + GTP => N(2)-(1-hydroxy-2-oxoethyl)-GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936590", "l": "sulfur transfer to carrier protein (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54360", "l": "4-methyl-2-oxopentanoate + H(+) = 3-methylbutanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043999", "l": "histone H2AK5 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-517705", "l": "p-S318,221-HuR binds mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55039", "l": "an N,N-dimethylornithine lipid + S-adenosyl-L-methionine <=> an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16201", "l": "4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.38", "l": "\"aminodeoxychorismate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016751", "l": "S-succinyltransferase activity", "d": ["Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696822", "l": "AKR1B15 reduces EST17b to E1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30066", "l": "2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> H(+) + menaquinol-8 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008427", "l": "calcium-dependent protein kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a calcium-dependent protein kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653936", "l": "Formation of Ragulator complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0016781", "l": "phosphotransferase activity, paired acceptors", "d": ["Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76630", "l": "(S)-2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) <=> H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57558", "l": "2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1 => (4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876454", "l": "DENND3 exchanges GTP for GDP on RAB12 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70216", "l": "cortisol + H(+) + NADPH => 20beta-dihydrocortisol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74715", "l": "Autophosphorylation of insulin receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672969", "l": "Phosphorylation of RAF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106325", "l": "acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42974", "l": "a cardiolipin + ethanolamine => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56552", "l": "ATP + L-threonyl-[rhodopsin] = ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38211", "l": "hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022065", "l": "DSPGs are secreted (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052691", "l": "UDP-arabinopyranose mutase activity", "d": ["Catalysis of the reaction: UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002172", "l": "high-affinity IgM receptor activity", "d": ["Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58425", "l": "(E)-hex-2-en-1-ol + NADP(+) => (E)-hex-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-381608", "l": "cAMP activates EPAC2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58616", "l": "N-octanoyl-(2S)-hydroxyglycine = glyoxylate + octanamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691507", "l": "ASPA deacetylates NAA to acetate and L-aspartate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27417", "l": "2 Fe(III)-[cytochrome] + H2O + nicotinate = 6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.17.2.1", "l": "\"nicotinate dehydrogenase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78705", "l": "2-oxoglutarate + L-phosphinothricin => 4-(hydroxy(methyl)phosphoryl)-2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389026", "l": "Galanin receptors can bind galanin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48373", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0003937", "l": "IMP cyclohydrolase activity", "d": ["Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10472", "l": "(2R,3S)-2,3-dimethylmalate = propanoate + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.32", "l": "\"2,3-dimethylmalate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73932", "l": "Resynthesis of excised residue by POLB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11861", "l": "ATP + L-histidyl-[protein] => ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21655", "l": "2-chlorobenzoate + H(+) + NADH + O2 <=> catechol + chloride + CO2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983427", "l": "Expression of peptide bound class I MHC on cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047052", "l": "(S)-stylopine synthase activity", "d": ["Catalysis of the reaction: (S)-cheilanthifoline + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-stylopine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.21.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947541", "l": "Sulfhydrylation and ring cleavage of precursor Z (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19529", "l": "isovitexin + UDP-alpha-D-glucose = H(+) + isovitexin 2''-O-beta-D-glucoside + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.106", "l": "\"isovitexin beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247840", "l": "WLS binds WNT ligands in the Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24905", "l": "3',3'-c-di-GMP + H2O <=> 5'-phosphoguanylyl(3'->5')guanosine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3209165", "l": "ID1 sequesters ETS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11491", "l": "all-trans-retinol + an acyl-CoA <=> an all-trans-retinyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9660192", "l": "VDR agonists bind VDR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56676", "l": "dihydroferuloyl-CoA + NADP(+) = (E)-feruloyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168638", "l": "Activated IKK phosphorylates I-kappaB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73631", "l": "CTP(out) + dGTP(in) = CTP(in) + dGTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53980", "l": "(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9680443", "l": "ROCK1,2 bind ROCKi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27425", "l": "(2E,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.47", "l": "\"beta-farnesene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22919", "l": "4'-hydroxyacetophenone + H(+) + NADPH + O2 <=> 4-acetoxyphenol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51015", "l": "a monoacyl-sn-glycero-3-phosphocholine + H2O <=> a monoacylglycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106335", "l": "tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity", "d": ["Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65050", "l": "4-acetoxybenzaldehyde + H(+) + NADH => 4-acetoxybenzyl alcohol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.147", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9624017", "l": "p-SHC1 binds integrin alpha5beta1:fibronectin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086087", "l": "voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization", "d": ["Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9772351", "l": "Disassembly of the Intron Lariat Spliceosome (new) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73903", "l": "ATP + ethanolamine + L-glutamate = ADP + gamma-L-glutamylethanolamide + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021949", "l": "MEF2C gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322422", "l": "Beta-catenin recruits SMARCA4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30055", "l": "L-allo-threonine + NADP(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444572", "l": "Zinc is an agonist of GPR39 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40704", "l": "(9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate => 1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77974", "l": "all-trans-hexaprenyl diphosphate <=> diphosphate + talaropentaene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38660", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71977", "l": "glutathione(in) + 3 Na(+)(in) => glutathione(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602458", "l": "Activation of proMMP10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050272", "l": "S-carboxymethylcysteine synthase activity", "d": ["Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17710", "l": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate => 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65927", "l": "2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine <=> 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0016262", "l": "protein N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40025", "l": "diphosphate + syn-copalol => 9alpha-copalyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78985", "l": "allokutznerene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5633460", "l": "MDM2 binds TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990606", "l": "membrane scission GTPase motor activity", "d": ["Generation of a 'twisting' activity resulting in the scission of a membrane, driven by GTP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928580", "l": "SFKs phosphorylate EFNBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29391", "l": "GTP + H2O = diphosphate + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38255", "l": "(S)-malate + succinyl-CoA = (S)-malyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14598", "l": "a CDP-1,2-diacyl-sn-glycerol + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66487", "l": "16alpha-hydroxygypsogenate + UDP-alpha-D-glucose <=> 16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27714", "l": "GMP + H2O = guanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31281", "l": "(2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate => (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15000", "l": "deoxylimonoate + H2O <=> deoxylimononate D-ring-lactone + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50510", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein] => acetyl-CoA + N-terminal L-valyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11358", "l": "AH2 + NAD(+) => A + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76107", "l": "(11R)-methyl carlactonoate + 2-oxoglutarate + O2 = (11R)-hydroxymethyl carlactonoate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671742", "l": "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25899", "l": "H(+) + malonate <=> acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52124", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78209", "l": "4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+) => D-methionine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37336", "l": "5,6-dihydrothymine + H2O => 3-(carbamoylamino)-2-methylpropanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44307", "l": "a 1-acyl-sn-glycero-3-phosphate + dodecanoyl-CoA <=> a 1-acyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30364", "l": "fumonisin B1 + 2 H2O => (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 H(+) + 2 tricarballylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23699", "l": "myo-inositol + O2 <=> D-glucuronate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33440", "l": "glyoxal + H2O + O2 => glyoxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247837", "l": "WNT ligands traffic to the Golgi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879909", "l": "Activation of STAT5a/b by JAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19204", "l": "2'-deoxyguanosine + ATP <=> ADP + dGMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32005", "l": "diphosphate + isopimara-8(14),15-diene => (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28358", "l": "FAD + H(+) + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47409", "l": "(24E)-3alpha,7alpha-dihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O => (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46327", "l": "3-oxochol-4-en-22-oyl-CoA + A <=> 3-oxochola-4,17-dien-22-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41540", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.305", "l": "\"8-demethyl-8-alpha-L-rhamnosyl tetracenomycin-C 2'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35005", "l": "L-fucose(out) => L-fucose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71520", "l": "uridine(out) => uridine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23774", "l": "2,3-dihydroxy-p-cumate + H(+) + NADH => (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15626", "l": "Co-precorrin-6B + NAD(+) => Co-precorrin-6A + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53356", "l": "5,6-dihydrouridine(20b) in tRNA + NADP(+) = H(+) + NADPH + uridine(20b) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65995", "l": "calciol + hnu <=> 5,6-trans-vitamin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9770119", "l": "Formation of the Spliceosomal E complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57652", "l": "a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1alpha + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27311", "l": "naphthalene-1,2-diol + O2 => 2-hydroxychromene-2-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0043325", "l": "phosphatidylinositol-3,4-bisphosphate binding", "d": ["Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57952", "l": "H(+) + NADH + O2 + phenol = catechol + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.244", "l": "\"phenol 2-monooxygenase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71533", "l": "guanine(in) => guanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45245", "l": "(3E,5Z)-octadienoyl-CoA => (2E,4E)-octadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42264", "l": "H(+) + malonyl-[ACP] + octanoyl-CoA = 3-oxodecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.207", "l": "\"beta-ketodecanoyl-[acyl-carrier-protein] synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62615", "l": "adenosine(1832) in 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine(1832) in 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839367", "l": "TGFBR3_mem cleavage by MMPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018826", "l": "methionine gamma-lyase activity", "d": ["Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25997", "l": "H2O + N(1)-acetylspermine + O2 => H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166091", "l": "IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23464", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.174", "l": "\"glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25811", "l": "H2O + O2 + spermidine <=> 3-aminopropanal + H2O2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72971", "l": "5-oxo-L-proline(out) + 2 Na(+)(out) = 5-oxo-L-proline(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879724", "l": "Expression of PPARA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3927824", "l": "PRC1 SUMOylates CASP8AP2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47465", "l": "(3E,5Z)-tetradecadienoyl-CoA => (2E,5Z)-tetradecadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73359", "l": "ATP + beta-alanine + dopamine = AMP + beta-alanyl-dopamine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62529", "l": "digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) => dihydrodigoxin + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76291", "l": "Na(+)(out) + xanthine(out) = Na(+)(in) + xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761065", "l": "FOXF1 binds CDH11 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21363", "l": "ATP + beta-nicotinamide D-ribonucleotide + H(+) <=> diphosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008116", "l": "prostaglandin-I synthase activity", "d": ["Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70975", "l": "CS acetylates OA to citrate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25871", "l": "H2O + N(1),N(12)-diacetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25046", "l": "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0015343", "l": "siderophore-iron transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001156", "l": "TFIIIC-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052630", "l": "UDP-N-acetylgalactosamine diphosphorylase activity", "d": ["Catalysis of the reaction: UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-galactosamine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102332", "l": "fatty-acyl-[acp] elongase/decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA + H+ + a long-chain acyl-[acp] + a reduced electron acceptor = 2 carbon dioxide + coenzyme A + a terminal olefin + a holo-[acyl-carrier protein] + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39649", "l": "5'-deoxyadenosine + A + dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + H(+) + L-methionine + NH4(+) => AH2 + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835385", "l": "DUS2 binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59594", "l": "ADP + beta-alanyl-L-arginine + H(+) + phosphate => ATP + beta-alanine + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77423", "l": "cyclohexanecarbaldehyde + hydrogen cyanide = (2S)-2-cyclohexyl-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379464", "l": "COMT transfers Met to DOPAC to form HVA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9676264", "l": "Formation of the SET1B complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54512", "l": "peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.189", "l": "\"9,13-epoxylabda-14-ene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71999", "l": "O2 + preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + preaspterpenacid acid II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177934", "l": "EGFR autophosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53405", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071794", "l": "CAP-Gly domain binding", "d": ["Binding to a CAP-Gly domain of a protein. The CAP_Gly domain is a conserved, glycine-rich domain of about 42 residues found in some cytoskeleton-associated proteins, and features a novel protein fold containing three beta-sheets."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617642", "l": "HOXD3 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75466", "l": "choline(out) + n H(+)(in) <=> choline(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42921", "l": "S-adenosyl-L-methionine + uridine(1498) in 16S rRNA => H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13809", "l": "aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.35", "l": "\"aspulvinone dimethylallyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836515", "l": "p-PKR dimer phosphorylates PTPN2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848818", "l": "PTK6 phosphorylates CBL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46113", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68089", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] => a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10125", "l": "H(+) + NADPH + O2 + phenylacetone => benzyl acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30000", "l": "ATP + H2O + spermidine(out) => ADP + H(+) + phosphate + spermidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58591", "l": "dihydroprecondylocarpine acetate + NADPH <=> (+)-vincadifformine + acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10913", "l": "(R)-pantoate + ATP + beta-alanine => (R)-pantothenate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11837", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine => CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332235", "l": "CBL binds TGFBR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73590", "l": "CTP(out) + UMP(in) <=> CTP(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28193", "l": "2'-deoxyadenosine + H(+) + H2O <=> 2'-deoxyinosine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71762", "l": "2-oxoglutarate(out) + heptanedioate(in) <=> 2-oxoglutarate(in) + heptanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37702", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018717", "l": "9-phenanthrol glycosyltransferase activity", "d": ["Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46988", "l": "(R)-6-hydroxynicotine + O2 = 6-hydroxy-N-methylmyosmine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008963", "l": "phospho-N-acetylmuramoyl-pentapeptide-transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9017491", "l": "RHOJ GEFs activate RHOJ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43790", "l": "ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate => acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3341294", "l": "Superoxide reduces cytochrome c (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62513", "l": "2-oxoglutarate + melatonin + O2 => 2-hydroxymelatonin + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46500", "l": "2-oxoglutarate + O2 + UMP = CO2 + phosphate + succinate + uridine-5'-aldehyde", "d": [], "t": []}, {"i": "EC:1.14.11.49", "l": "\"uridine-5'-phosphate dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1912357", "l": "ITCH ubiquitinates DTX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373738", "l": "Neurofascin interacts with syntenin-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16923", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54273", "l": "2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54325", "l": "a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 oxidized 2[4Fe-4S]-[ferredoxin] => a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53011", "l": "(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate <=> di-trans,poly-cis-polyprenyl diphosphate + n diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62303", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + H(+) + NADPH <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-4H,6H,7H,8H-pyrrolo[1,2-a]pyrazine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11664", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.3.5", "l": "\"galactosyldiacylglycerol alpha-2,3-sialyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429786", "l": "SGMS2 transfers phosphocholine onto ceramide (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112042", "l": "Opioid binds MOR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.860469173664285", "identifiers": [{"i": "GO:0005319", "l": "lipid transporter activity", "d": ["Enables the directed movement of lipids into, out of or within a cell, or between cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2509827", "l": "ITPA hydrolyses ITP to IMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1963586", "l": "SRC family kinases phosphorylate ERBB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5444511", "l": "Formation of MSH2:MSH3 Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77579", "l": "(9Z)-octadecenoyl-CoA + 1-octanoylglycerol = 1-octanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68823", "l": "(2Z,6E)-farnesyl diphosphate + H2O <=> (6E)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52133", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O => a 5'-end 5'-phospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033442", "l": "AAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1889981", "l": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016864", "l": "intramolecular oxidoreductase activity, transposing S-S bonds", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears."], "t": []}, {"i": "EC:5.3.4.-", "l": "\"Transposing S-S bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64462", "l": "H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate => acetyl phosphate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44254", "l": "1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32834", "l": "an R-cob(III)alamin(in) <=> an R-cob(III)alamin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102027", "l": "S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity", "d": ["Catalysis of the reaction: 2-demethylmenaquinol-8 + S-adenosyl-L-methionine = menaquinol-8 + H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40260", "l": "(2E)-hexadecenedioyl-CoA + H2O => (3S)-hydroxyhexadecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814418", "l": "PDCL promotes formation of G-beta:G-gamma heterodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48824", "l": "GDP-beta-L-fucose + Lc4Cer = a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68970", "l": "H2O2 + phenylglyoxylate => mandelate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72347", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole = 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40459", "l": "(2S)-pristanoyl-CoA + O2 = (2E)-pristenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37791", "l": "aclacinomycin A + O2 = aclacinomycin Y + H2O2", "d": [], "t": []}, {"i": "EC:1.3.3.14", "l": "\"aclacinomycin-A oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37646", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48968", "l": "[thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 = [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78215", "l": "D-glutamine + H2O + O2 = 2-oxoglutaramate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9859098", "l": "MITF-M dimer binds the ASAH1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23974", "l": "(2E)-butenoyl-CoA + CO2 + Na(+)(out) => (2E)-glutaconyl-CoA + H(+) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854222", "l": "TBC1D3 associates with RAB5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3000433", "l": "SUMOylation of PML with SUMO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140823", "l": "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62787", "l": "2 fonsecin B + H(+) + NADPH + O2 <=> bifonsecin B + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37764", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA => 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.9.-", "l": "\"With a copper protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193668", "l": "p75NTR and RHOA-GDI interact (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55605", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-acyl-sphingoid base => a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-acylsphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45361", "l": "H2O + N-(11Z-eicosenoyl)-sphinganine => (11Z)-eicosenoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41633", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56445", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34392", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose => [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69411", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) <=> androst-4-ene-3,11,17-trione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77871", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-leucine + O2 = (2S)-4-methyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]pentanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2243926", "l": "Formation of histidino-hydroxylysinonorleucine cross-links (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78178", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol <=> a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65731", "l": "2-oxoglutarate + hexyl sulfate + O2 <=> CO2 + H(+) + hexanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44262", "l": "4-hydroxy-6-pentadecylpyran-2-one + 2 CO2 + 3 CoA => 2 H(+) + hexadecanoyl-CoA + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798615", "l": "TP53 binds the TP53AIP1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43913", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => (25R)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41614", "l": "D-ribose 2,5-bisphosphate + H(+) => alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047020", "l": "15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69980", "l": "(22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68547", "l": "(2Z,6Z)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75116", "l": "all-trans-13,14-dihydroretinol + NAD(+) => all-trans-13,14-dihydroretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37057", "l": "3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate => 3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0052905", "l": "tRNA (guanosine(9)-N1)-methyltransferase activity", "d": ["Catalysis of the reaction: guanosine9 in tRNA + S-adenosyl-L-methionine = H+ + N1-methylguanosine9 in tRNA + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61478", "l": "an N-octadecanoyl-sphingoid base + CoA + H(+) => a sphingoid base + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031762", "l": "follicle-stimulating hormone receptor binding", "d": ["Binding to a follicle-stimulating hormone receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050078", "l": "malonate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375131", "l": "Basigin binds CD98 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678920", "l": "TLR processing at low pH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73285", "l": "H(+)(in) + L-isoleucine(out) => H(+)(out) + L-isoleucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803063", "l": "RNASEs bind bacterial LPS, PGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30909", "l": "2-methylbutanoyl-CoA + CO2 + NADH => (S)-3-methyl-2-oxopentanoate + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868573", "l": "CDK5:p25 phosphorylates PRDX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5652099", "l": "Defective SLC35A2 does not exchange UDP-Gal, UDP-GalNAc for UMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69571", "l": "(2S)-2-amino-4-deoxychorismate + H2O + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836621", "l": "p-S225-SPHK1 localizes to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696822", "l": "AKR1B15 reduces EST17b to E1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70136", "l": "6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57266", "l": "GDP + glycolate + H(+) => H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73805", "l": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003853", "l": "2-methylbutanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74388", "l": "formamide(out) => formamide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19665", "l": "6-carboxyhexanoyl-CoA + NAD(+) = 6-carboxyhex-2-enoyl-CoA + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.62", "l": "\"pimeloyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187506", "l": "Translocation of p27 to the nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44249", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58608", "l": "2 L-ascorbate + N-decanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74505", "l": "H2O + NADP(+) + penigequinolone B => H(+) + NADPH + yaequinolone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51144", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + 2 O2 = (10,17)-dihydroperoxy-(7Z,11Z,13Z,15E,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50598", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H4] => acetyl-CoA + N-terminal L-seryl-[histone H4]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29226", "l": "menaquinone-8 + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2990882", "l": "CDK1 phosphorylates NUP98 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28036", "l": "[thioredoxin]-dithiol + ADP => [thioredoxin]-disulfide + dADP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018591", "l": "methyl tertiary butyl ether 3-monooxygenase activity", "d": ["Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018577", "l": "catechol 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210977", "l": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199112", "l": "CRTAM binds to NECL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388808", "l": "CD28 homodimer binds B7-2 monomer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047445", "l": "3-hydroxy-3-isohexenylglutaryl-CoA lyase activity", "d": ["Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA + 4 H+ = 7-methyl-3-oxooct-6-enoyl-CoA + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27471", "l": "acetate + N-acetyl-beta-D-glucosaminyl-(1->4)-D-glucosamine => H2O + N,N'-diacetylchitobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71320", "l": "chloride(out) + L-cysteine(out) + 2 Na(+)(out) => chloride(in) + L-cysteine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098619", "l": "selenocysteine-tRNA ligase activity", "d": ["Catalysis of the reaction: tRNASec + L-Ser + ATP = Ser-tRNASec + AMP + diphosphate."], "t": []}, {"i": "REACT:R-HSA-2408526", "l": "tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000319", "l": "BORA binds PLK1 and AURKA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070577", "l": "lysine-acetylated histone binding", "d": ["Binding to a histone in which a lysine residue has been modified by acetylation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53504", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate", "d": [], "t": []}, {"i": "EC:4.1.99.23", "l": "\"5-hydroxybenzimidazole synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983011", "l": "Expression of STAT5 upregulated genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77094", "l": "Formation of cap binding complex (CBC) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45974", "l": "9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+) => 3-oxochol-4-en-22-oate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0106006", "l": "cytoskeletal protein-membrane anchor activity", "d": ["The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a plasma membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific cortical membrane location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24697", "l": "(E)-isoeugenol + acetate + NADP(+) <=> (E)-coniferyl acetate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55427", "l": "(3S,6E)-nerolidol + O2 + reduced [NADPH--hemoprotein reductase] <=> (3E)-4,8-dimethylnona-1,3,7-triene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64904", "l": "GTP + 2 H2O = GMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043522", "l": "leucine zipper domain binding", "d": ["Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14946", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947535", "l": "Cyclisation of GTP to precursor Z (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003881", "l": "CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity", "d": ["Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45557", "l": "H2O + N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-dodecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35310", "l": "H(+) + NADH + O2 + salicylate <=> 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9825788", "l": "p-S207 KARS displaces HINT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46704", "l": "ATP + H(+) + salicylate = 2-hydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031780", "l": "corticotropin hormone receptor binding", "d": ["Binding to a corticotropin hormone receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55482", "l": "ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842876", "l": "NuRD complex binds SUMO2-6K-TRIM28:KRAB-ZNF:retroelement (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688834", "l": "ATXN3 binds VCP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12553", "l": "(E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA => (E)-pinosylvin + 4 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62290", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate => (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430096", "l": "GP1b-IX-V binds filamin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201622", "l": "Caspase-mediated cleavage of gelsolin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72328", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + vanillate => 3,4-dihydroxybenzoate + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58865", "l": "4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31982", "l": "NADPH + O2 + trimethylamine <=> H2O + NADP(+) + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18326", "l": "(2E,6E)-farnesyl diphosphate => (+)-amorpha-4,11-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38104", "l": "L-galactonate => 2-dehydro-3-deoxy-L-galactonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66169", "l": "[protein]-with a C-terminal TM segment(out) + ATP + H2O => [protein]-with a C-terminal TM segment(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19903", "l": "alpha,beta-didehydrotryptophan + H2O2 => L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9825751", "l": "HINT1 binds MITF-M (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64099", "l": "3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] <=> 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17670", "l": "3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O2 => 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70899", "l": "histidine => urocanate + NH4+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36445", "l": "6,8-dimethyl-6,7-didehydroergoline + H2O => dihydrochanoclavine-I aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112430", "l": "Formation of P-TEFb complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696491", "l": "CNTF binds CNTFR complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26534", "l": "3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.36", "l": "\"3-hydroxypropionyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264435", "l": "Dissociation of the COP1-p53 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11866", "l": "dimethylamine + formaldehyde + reduced [electron-transfer flavoprotein] => H(+) + H2O + oxidized [electron-transfer flavoprotein] + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39433", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004071", "l": "aspartate-ammonia ligase activity", "d": ["Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45934", "l": "4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA => 2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5661217", "l": "MT1A binds zinc (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0050321", "l": "tau-protein kinase activity", "d": ["Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014293", "l": "RAC2 GDIs block activation of RAC2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420265", "l": "AMY1-3 bind IAPP(34-70) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41575", "l": "lipoxin A4 + NAD(+) <=> 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28929", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + 2 H(+) => 3,4,5-trihydroxybenzoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68516", "l": "(2Z,6Z)-farnesyl diphosphate = beta-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22723", "l": "ATP + L-histidyl-[protein] <=> ADP + H(+) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65061", "l": "NADP(+) + taurochenodeoxycholate => 7-oxotaurolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432143", "l": "PECAM-1 binds PP2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56881", "l": "a 3beta-hydroxy-Delta(5)-steroid + NADP(+) => a 3-oxo-Delta(5)-steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018712", "l": "3-hydroxybutyryl-CoA thiolase activity", "d": ["Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68918", "l": "CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20385", "l": "(2R,3R)-dihydroquercetin + H(+) + NADH + O2 = (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23137", "l": "a primary amine + S-adenosyl-L-methionine => a methylated primary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43757", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62661", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol => (2'R)-atrovenetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654514", "l": "KAL1 binds FGFR1c (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0004571", "l": "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000404", "l": "heteroduplex DNA loop binding", "d": ["Binding to a DNA segment containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13435", "l": "2'-deoxyuridine + NH4(+) => 2'-deoxycytidine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51964", "l": "2-methylpropanenitrile + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylpropanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78655", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + silphinene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10264", "l": "alpha-D-glucose = beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50771", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine <=> anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102770", "l": "inositol phosphorylceramide synthase activity", "d": ["Catalysis of the reaction: an L-1-phosphatidyl-inositol + a dihydroceramide = an inositol phosphodihydroceramide + a 1,2-diacyl-sn-glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679045", "l": "C-ter TLR9 dimer binds HCQ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983147", "l": "Release of E3 from polyubiquitinated substrate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.514861039037328", "identifiers": [{"i": "GO:0005543", "l": "phospholipid binding", "d": ["Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74980", "l": "(3R)-3-isocyanylbutanoate + ATP + H(+) => (3R)-3-isocyanylbutanoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74943", "l": "2-oxoglutarate + a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + O2 = a (3R)-3-isocyanyl-fatty acid + 2 CO2 + 2 H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944220", "l": "Association of procollagen type XXIII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9704248", "l": "CHRM4 binds CHRM4 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29925", "l": "ADP + alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73607", "l": "CTP(out) + dCTP(in) = CTP(in) + dCTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78876", "l": "a medium-chain (3R)-hydroxyacyl-CoA + NAD(+) => a medium-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16486", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate => 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67911", "l": "a primary linear alkyl sulfate ester + H2O <=> a primary alcohol + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229283", "l": "LCNs bind lipids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32802", "l": "urea(in) <=> urea(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047582", "l": "4-methyleneglutaminase activity", "d": ["Catalysis of the reaction: 4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53271", "l": "L-ribulose <=> L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64122", "l": "a fatty acid + L-serine => an N-(fatty acyl)-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050528", "l": "acyloxyacyl hydrolase activity", "d": ["Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29375", "l": "AMP + H2O = adenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791363", "l": "TP53 stimulates ARID3A gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65014", "l": "AMP + decanoyl-[ACP] + H(+) => decanoyl-AMP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16260", "l": "alpha,alpha-trehalose + phosphate <=> alpha-D-glucose + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022383", "l": "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60983", "l": "12-hydroxydodecanoate + NAD(+) <=> 12-oxododecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63655", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601924", "l": "Primary piRNA transcript translocates from nucleoplasm to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.-", "l": "\"Phosphoric diester hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20350", "l": "H(+) + NADH + O2 + toluene => 2-hydroxytoluene + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64607", "l": "L-seryl-[protein] + UTP <=> diphosphate + uridylyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000907", "l": "sulfonate dioxygenase activity", "d": ["Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4225086", "l": "Defective mitochondrial BTD does not hydrolyse BCTN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.75", "l": "\"glucan endo-1,6-beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204873", "l": "Interaction of Tie2 and Shp2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804879", "l": "MDM2 ubiquitinates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78972", "l": "(2E)-3-methyl-5-phosphooxypent-2-enoate + H(+) => CO2 + isopentenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168929", "l": "Viral dsRNA:TLR3 recruits TRIF (TICAM1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73994", "l": "geranylgeranyl diphosphate <=> beta-araneosene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21210", "l": "L-serine + phosphate => H2O + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40468", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O => (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376117", "l": "JLP interacts with CDO complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419011", "l": "Transhomodimerization of Nectins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071618", "l": "lysophosphatidylethanolamine acyltransferase activity", "d": ["Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5684140", "l": "ATM phosphorylates RBBP8 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0000217", "l": "DNA secondary structure binding", "d": ["Binding to a DNA secondary structure element such as a four-way junction, a bubble, a loop, Y-form DNA, or a double-strand/single-strand junction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.68", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40705", "l": "1-O-(9Z,12Z)-octadecadienylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z,12Z)-octadecadien-1-ol + 1-hexadecanoylglycerone 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41158", "l": "1-hexadecanoyl-2-(10-hydroperoxy-8E-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 10-hydroperoxy-(8E)-octadecenoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216072", "l": "Interaction of integrin alphaIIbbeta3 with von Willebrand factor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10736", "l": "a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015169", "l": "glycerol-3-phosphate transmembrane transporter activity", "d": ["Enables the transfer of glycerol-3-phosphate from one side of a membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20217", "l": "H(+) + trimethylamine N-oxide = dimethylamine + formaldehyde", "d": [], "t": []}, {"i": "EC:4.1.2.32", "l": "\"trimethylamine-oxide aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64162", "l": "ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase] => ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382058", "l": "Nck binds to the active PDGF receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.188221489317044", "identifiers": [{"i": "GO:0140102", "l": "catalytic activity, acting on a rRNA", "d": ["Catalytic activity that acts to modify a ribosomal RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45072", "l": "(9Z)-octadecenoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z)-18-hydroxyoctadecenoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77583", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol = 1-octadecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.96.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9793444", "l": "ITCH polyubiquitinates MLKL at K50 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161951", "l": "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64481", "l": "4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate => (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37875", "l": "aklanonate + S-adenosyl-L-methionine = methyl aklanonate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.288", "l": "\"aklanonic acid methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202472", "l": "Translocation of TRAF6 to CBM complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63227", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 <=> 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66254", "l": "AMP + diphosphate + IC-asc-C7-CoA => ATP + CoA + IC-asc-C7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68597", "l": "(2E,6E)-farnesyl diphosphate => beta-cadinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106313", "l": "methylenetetrahydrofolate reductase (NADPH) activity", "d": ["Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP+ = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429767", "l": "Passive I- efflux mediated by SLC5A8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44821", "l": "1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) => 2-demethylmenaquinol-13 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047452", "l": "protoaphin-aglucone dehydratase (cyclizing) activity", "d": ["Catalysis of the reaction: protoaphin aglucone = H2O + xanthoaphin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202717", "l": "Heterodimerization of CEACAMs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40213", "l": "3-oxotetradecanedioyl-CoA + H(+) + NADH => (3S)-hydroxytetradecanedioyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17447", "l": "2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2 + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67759", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16645", "l": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate", "d": [], "t": []}, {"i": "EC:3.1.2.2", "l": "\"palmitoyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47160", "l": "4beta-methylzymosterol-4alpha-carboxylate + NAD(+) = 3-dehydro-4-methylzymosterol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008935", "l": "1,4-dihydroxy-2-naphthoyl-CoA synthase activity", "d": ["Catalysis of the reaction: 2-succinylbenzoyl-CoA + H+ = 1,4-dihydroxy-2-naphthoyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57208", "l": "glyoxal + L-cysteinyl-[protein] = S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9695949", "l": "SPHK2 phosphorylates sphingoid (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11310", "l": "ADP + H(+) + malonyl-CoA + phosphate => acetyl-CoA + ATP + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40309", "l": "(2E)-decenedioyl-CoA + AH2 => A + decanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1168376", "l": "STIM1 oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35765", "l": "aflatoxin B2 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase] => 8-O-methyldihydrosterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17060", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937820", "l": "SRC,YES1 bind YAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162188", "l": "COQ5 methylates MDMQ10H2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43017", "l": "an S-alkyl-L-cysteine => 2-aminoprop-2-enoate + an alkyl thiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23195", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30223", "l": "2 Fe(III)-[cytochrome c] + hydrogen sulfide = 2 Fe(II)-[cytochrome c] + H(+) + sulfur", "d": [], "t": []}, {"i": "EC:1.8.2.3", "l": "\"sulfide-cytochrome-c reductase (flavocytochrome c)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.29", "l": "\"polyporopepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652172", "l": "AKR1B1 reduces Glc to D-sorbitol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169398", "l": "ISGylation of host protein filamin B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102302", "l": "mycinamicin VI 2''-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + mycinamicin VI = S-adenosyl-L-homocysteine + mycinamicin III(1+) + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.44", "l": "\"atrolysin E\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2176445", "l": "SMURF2 binds SMAD2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76583", "l": "(2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + 2 H(+) + NADH = (6S)-3,3-dimethylpiperidine-2,6-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28419", "l": "(R)-carnitine + 4-(trimethylamino)butanoyl-CoA => (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53189", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-(N-9Z-octadecenoyl)-ethanolamine + H2O => 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49475", "l": "trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose <=> H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15182", "l": "an acyl-CoA(out) + ATP + H2O => ADP + an acyl-CoA(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31676", "l": "NADP(+) + raucaffrinoline => H(+) + NADPH + perakine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-532678", "l": "Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2172433", "l": "Collagen type XIX degradation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050488", "l": "ecdysteroid UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36687", "l": "hexadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31038", "l": "arabidiol <=> (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65933", "l": "3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine => 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72631", "l": "Formation of the cap-binding eIF4F complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32986", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41680", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) = a 2-all-trans-polyprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.2.3", "l": "\"thiazoline synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.40", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730841", "l": "Phosphorylation and activation of VAV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-507868", "l": "Aquaporins passively transport water into cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60173", "l": "5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + H(+) + selenophosphate => (2E)-thiogeraniol + 5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51886", "l": "D-proline betaine => L-proline betaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60763", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone <=> CoA + jasmolin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636240", "l": "PPE2 binds NOS2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003987", "l": "acetate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695845", "l": "FLT3 mutant dimers:GRB2 bind SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114563", "l": "Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371467", "l": "SIRT1 deacetylates HSF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419389", "l": "LPA-binding receptors bind LPA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25152", "l": "2-oxoglutarate + L-phenylalanine = 3-phenylpyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77843", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-tyrosine + O2 = 2-dehydro-D-glucose + H2O2 + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68137", "l": "acetophenone + H(+) + NADPH => (R)-1-phenylethanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20152", "l": "O2 + quinine + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32757", "l": "apigenin + CO2 + H(+) + H2O + succinate => (2S)-naringenin + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61241", "l": "H2O + L-phenylalanine + O2 => 3-phenylpyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75326", "l": "chloride(out) + D-leucine(out) + 2 Na(+)(out) <=> chloride(in) + D-leucine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451439", "l": "Activated TLR7 or 21 recruits MyD88 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4088281", "l": "Endorepellin binds KDR (VEGFR2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140768", "l": "protein ADP-ribosyltransferase-substrate adaptor activity", "d": ["An enzyme-substrate adaptor that bings together a protein ADP-ribosyl transferase and its substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15384", "l": "O2 + quercetin <=> 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202472", "l": "Translocation of TRAF6 to CBM complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756470", "l": "N binds to heme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27760", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+) => (6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23267", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADP(+) <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76830", "l": "butylamine + H2O + NAD(+) <=> butanal + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56992", "l": "6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = (+)-costunolide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3000310", "l": "AURKA phosphorylates PLK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37052", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22256", "l": "a (3R)-3-hydroxyacyl-CoA + NADP(+) = a 3-oxoacyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47762", "l": "a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in 21S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40235", "l": "coenzyme B + coenzyme M + fumarate = coenzyme M-coenzyme B heterodisulfide + succinate", "d": [], "t": []}, {"i": "EC:1.3.4.1", "l": "\"fumarate reductase (CoM/CoB)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814374", "l": "Kazrin binds periplakin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44951", "l": "1-O-alkyl-2,3-diacyl-sn-glycerol + H2O <=> 1-O-alkyl-2-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29530", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.-.-.-", "l": "\"Transferases\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202709", "l": "JAM2 dimerises (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19463", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+) => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51475", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795667", "l": "MDM2 translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39117", "l": "4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH => 4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757258", "l": "MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193702", "l": "Part of the ICD migrates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45080", "l": "3-[[[(2R,3R)-3-carboxyoxiran-2-yl]carbonyl]amino]-L-alanine + ATP + L-valine = ADP + dapdiamide E + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14793", "l": "2-hydroxyadipate + NAD(+) = 2-oxoadipate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.172", "l": "\"2-oxoadipate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73231", "l": "2,4,6-trichlorophenol + FADH2 + O2 = 2-chloro-6-hydroxy-1,4-benzoquinone + 2 chloride + FAD + 3 H(+)", "d": [], "t": []}, {"i": "EC:1.14.14.173", "l": "\"2,4,6-trichlorophenol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27925", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 <=> 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5695964", "l": "ABHD14B hydrolyses PNPB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73495", "l": "an 8-hydroxyflavone + S-adenosyl-L-methionine = an 8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66876", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 12-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448480", "l": "IL22 binds IL22RA1:JAK1 receptor complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22514", "l": "hydrogenobyrinate => 3 H(+) + precorrin-8X", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2179387", "l": "Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008315", "l": "TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369028", "l": "ABCAs mediate lipid efflux (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35548", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76095", "l": "(11R)-19-oxocarlactone + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-carlactonoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2731141", "l": "Syndecan-1 binds fibronectin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65786", "l": "3-(4-chlorophenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + monuron + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16548", "l": "formyl-CoA + oxalate <=> formate + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34060", "l": "agroclavine + NADP(+) => didehydroagroclavine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66146", "l": "CoA + H(+) + melatonin => 5-methoxytryptamine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807008", "l": "PTPRJ dephosphorylates MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4420121", "l": "SFKs phosphorylate PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43392", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 1,3-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111962", "l": "PDE4A,C,D hydrolyse cAMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20114", "l": "beta-D-glucose 1-phosphate => beta-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64053", "l": "(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine => CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37869", "l": "1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164507", "l": "CD4:gp120  binds to chemokine co-receptor CCR5/CXCR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497824", "l": "BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102054", "l": "maleylpyruvate hydrolase activity", "d": ["Catalysis of the reaction: 3-maleylpyruvate(2-) + H2O = H+ + maleate(2-) + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63947", "l": "a fatty acyl-CoA + sphinga-4E,14Z-dienine <=> an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25544", "l": "ent-copalyl diphosphate = diphosphate + ent-pimara-9(11),15-diene", "d": [], "t": []}, {"i": "EC:4.2.3.31", "l": "\"ent-pimara-9(11),15-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76751", "l": "5-hydroxydodecanoate + H(+) = delta-dodecalactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49611", "l": "2-glutathionyl-2-methylbut-3-enal + H2O + NAD(+) <=> 2-glutathionyl-2-methylbut-3-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.43", "l": "\"prepilin peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0046993", "l": "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen."], "t": []}, {"i": "EC:1.21.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47202", "l": "(24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH => (24S)-7alpha-dihydroxycholesterol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4647593", "l": "EP400 binds CDKN1A promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17271", "l": "H(+) + S-adenosyl-L-homocysteine + tylosin => macrocin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090556", "l": "phosphatidylserine floppase activity", "d": ["Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}, {"i": "RHEA:38567", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10336", "l": "citrate = D-threo-isocitrate", "d": [], "t": []}, {"i": "EC:4.2.1.3", "l": "\"aconitate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791291", "l": "TP53 stimulates BID gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50709", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione => (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48259", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17169", "l": "acetyl-CoA + alpha-D-galactosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": [], "t": []}, {"i": "EC:2.3.1.276", "l": "\"galactosamine-1-phosphate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016767", "l": "geranylgeranyl-diphosphate geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004977", "l": "melanocortin receptor activity", "d": ["Combining with melanocortin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052765", "l": "reduced coenzyme F420 oxidase activity", "d": ["Catalysis of the reaction: 2 reduced coenzyme F420 + O2 = 2 coenzyme F420 + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23281", "l": "acetyl-CoA + cysteamine => CoA + S-acetylcysteamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77335", "l": "[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-1-O,3-O-dimethyl-alpha-D-mannose + GDP-alpha-D-mannose = alpha-D-mannosyl-(1->4)-[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-1-O,3-O-dimethyl-alpha-D-mannose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54662", "l": "an aromatic aldehyde + hydrogen cyanide => an aromatic (S)-hydroxynitrile", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9676257", "l": "Formation of the SET1A complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23449", "l": "3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP => CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23093", "l": "H(+) + H2O + hydroxyatrazine => ethylamine + N-isopropylammelide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627106", "l": "SMAC (DIABLO) forms dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12581", "l": "H2O + NAD(+) + tauropine => H(+) + NADH + pyruvate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66584", "l": "3-oxocholestane + A + H2O = 25-hydroxy 3-oxocholestane + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781905", "l": "ZRANB1 binds APC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170846", "l": "TGFBR2 recruits TGFBR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45146", "l": "acetaldehyde + CO2 + CoA + methanethiol => 3-(methylsulfanyl)acryloyl-CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41441", "l": "(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 => (1R)-(2-amino-1-hydroxyethyl)phosphonate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5672011", "l": "p-AMPK:AMP binds the ULK complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156699", "l": "Inactivation of Wee1 kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52890", "l": "H(+) + NADPH + nitrosobenzene => N-phenylhydroxylamine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22407", "l": "beta-D-galacturonate + NAD(+) <=> D-galactaro-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24560", "l": "acetyl-CoA + L-serine = CoA + O-acetyl-L-serine", "d": [], "t": []}, {"i": "EC:2.3.1.30", "l": "\"serine O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35668", "l": "a triacylglycerol + H2O => a 1,2-diacylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49782", "l": "CoA + H(+) + N-docosanoylglycine => docosanoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27611", "l": "formate + H(+) => CO2 + H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177926", "l": "Dephosphorylation of PAG by SHP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61051", "l": "lochnericine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78383", "l": "L-cysteinyl-[SCAN] + S-nitroso-CoA = CoA + S-nitroso-L-cysteinyl-[SCAN]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605591", "l": "GBA1:SAPC hydrolyzes GlcCer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15416", "l": "(2R,3R)-tartrate <=> H2O + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.045601261176557", "identifiers": [{"i": "GO:0008378", "l": "galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid."], "t": []}, {"i": "REACT:R-HSA-1964501", "l": "Addition of galactose to Core 6 glycoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58783", "l": "a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine <=> a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2895778", "l": "POU5F1 (OCT4), STAT3 bind the SALL4 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186819", "l": "SH2 domain of Src binds to the active receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67699", "l": "H2O + hexadecanedioyl-CoA <=> CoA + H(+) + hexadecanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698029", "l": "p-STAT5 dissociates from mutant FLT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.60", "l": "\"diadenosine hexaphosphate hydrolase (AMP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52533", "l": "adenosine + GTP => AMP + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9834076", "l": "PINK1 is autophosphorylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33054", "l": "choline + NAD(+) <=> betaine aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662466", "l": "XYLB phosphorylates D-xylulose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78104", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine => a 2-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78230", "l": "D-histidine + H2O + O2 <=> 3-(imidazol-5-yl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16496", "l": "glycerol 1,2-cyclic phosphate + H2O <=> glycerol 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050408", "l": "[pyruvate kinase]-phosphatase activity", "d": ["Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38149", "l": "carbonyl sulfide + H(+) + hydrogen sulfide => carbon disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28217", "l": "[thioredoxin]-dithiol + prostaglandin H2 <=> [thioredoxin]-disulfide + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817936", "l": "Expression of KDM4E in the embryo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77206", "l": "3'-phosphoadenylyl sulfate + deoxycholate <=> 3alpha-sulfodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10300", "l": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23951", "l": "4-hydroxybutanoate + NAD(+) <=> H(+) + NADH + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193401", "l": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69678", "l": "eriodictyol-7-O-beta-D-glucoside + H2O <=> (S)-eriodictyol + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879322", "l": "mycothione is reduced to mycothiol (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795460", "l": "SGK1 phosphorylates MDM2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389632", "l": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49332", "l": "2-hydroxyspheroidene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,2-dihydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25073", "l": "3-hydroxybenzoate + ATP + CoA <=> 3-hydroxybenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58062", "l": "acetaldehyde + H(+) + sulfite => 2-sulfinoacetaldehyde + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008199", "l": "ferric iron binding", "d": ["Binding to a ferric iron ion, Fe(III)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52838", "l": "H2O + indoxyl + NAD(+) => H(+) + indole + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327733", "l": "FN1 binds Collagen types I-V, VII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16946", "l": "(6S)-5,6,7,8-tetrahydrofolate + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381644", "l": "ER calcium channels open in response to activated PKA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76850", "l": "(R)-sec-butylamine + H2O + NAD(+) <=> butan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987156", "l": "p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749647", "l": "CES2 hydrolyzes ASA- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3132759", "l": "TCN1 binds RCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12815", "l": "D-glutamate => L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244415", "l": "botA HC:LC binds SV2A, B, or C and GT1b on the target cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26115", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + epi-cedrol", "d": [], "t": []}, {"i": "EC:4.2.3.39", "l": "\"epi-cedrol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38336", "l": "(20S)-ginsenoside Rb1 + 2 H2O => (20S)-ginsenoside Rg3 + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31456", "l": "NAD(+) + reduced riboflavin => 2 H(+) + NADH + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33796", "l": "H2O + sucrose => alpha-D-glucose + beta-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5689630", "l": "BAP1 binds BAP1-interacting complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33505", "l": "ADP + H(+) + itraconazole(out) + phosphate => ATP + H2O + itraconazole(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437192", "l": "PDPK1 binds PRKCZ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0008397", "l": "sterol 12-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O."], "t": []}, {"i": "EC:1.14.14.139", "l": "\"5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61476", "l": "a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.299", "l": "\"sphingoid base N-stearoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024967", "l": "BDNF-bound NTRK2 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72095", "l": "Internal Methylation of mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635859", "l": "GLI:SUFU dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799203", "l": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.50", "l": "\"tabersonine 3-oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43720", "l": "juvenile hormone III carboxylate + S-adenosyl-L-methionine = juvenile hormone III + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428262", "l": "ACER3 hydrolyzes phytoceramide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1592316", "l": "Initial activation of proMMP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467811", "l": "Separation of sister chromatids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038198", "l": "auxin receptor activity", "d": ["Combining with auxin and transmitting the signal in the cell to initiate a change in cell activity. Auxin is a plant hormone (phytohormone)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46331", "l": "L-threo-3-phenylserine <=> 3-phenylpyruvate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17910", "l": "(S)-lactate => acetaldehyde + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59963", "l": "N(alpha)-acetyl-D-methionine <=> N(alpha)-acetyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72144", "l": "AH2 + GTP + S-adenosyl-L-methionine => 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69074", "l": "Formation of Processive Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39617", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H2O => (3R)-hydroxy-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29292", "l": "(25S)-3-oxocholest-4-en-26-oate + ATP + CoA => (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211186", "l": "Cleavage of DFF45 (224) by caspase-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.7.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734274", "l": "Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805470", "l": "AMPK phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24900", "l": "3',3'-c-di-GMP + 2 diphosphate => 2 GTP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67290", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine => ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32727", "l": "a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.199", "l": "\"very-long-chain 3-oxoacyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47194", "l": "Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389348", "l": "Activation of Rac1 by pVav1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39424", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA => (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31228", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine => di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610327", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN3B (GRIN3B) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784765", "l": "p-Y705-STAT3 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-593685", "l": "Netrin-4 binds DCC/UNC5A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10592", "l": "a 3',5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 3'-hydroxy,5'-unsubstituted flavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18084", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + pentalenene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195726", "l": "Association of  NA into rafts (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9689680", "l": "IFNG dimer binds IFNG inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36546", "l": "H2O + mycothiol S-conjugate <=> 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35801", "l": "7,8-dihydroneopterin 3'-phosphate + H(+) => 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428918", "l": "Dissociation of the TP:G13 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54362", "l": "3-methylbutanal + CO2 => 4-methyl-2-oxopentanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21158", "l": "(R)-glycerate + phosphate => (2R)-2-phosphoglycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605723", "l": "NEU2 cleaves GM3 to form LacCer (cytosol) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59766", "l": "CoA + H(+) + N(6)-octadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] => L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66580", "l": "3'-phosphoadenylyl sulfate + bisphenol A = adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-421831", "l": "trans-Golgi Network Coat Assembly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678944", "l": "Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2172433", "l": "Collagen type XIX degradation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72062", "l": "glycochenodeoxycholate(out) + 2 Na(+)(out) <=> glycochenodeoxycholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74392", "l": "methylamine(out) => methylamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000433", "l": "SUMOylation of PML with SUMO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34164", "l": "hydroquinone + O2 => (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.71648590403835", "identifiers": [{"i": "GO:0097506", "l": "deaminated base DNA N-glycosylase activity", "d": ["DNA N-glycosylase activity acting on deaminated bases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018746", "l": "RHOQ binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37792", "l": "aclacinomycin A + O2 => aclacinomycin Y + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714691", "l": "RAC3 binds ER effectors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79012", "l": "ent-copalyl diphosphate => diphosphate + ent-beyerene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64495", "l": "3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] <=> dehydrocitreoisocoumarin + H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40061", "l": "CoA + decanoate + H(+) => decanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678981", "l": "TLR9 processing at neutral pH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734540", "l": "ACLY tetramer binds ETC-1002-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001006", "l": "RNA polymerase III type 3 promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22608", "l": "H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + succinate", "d": [], "t": []}, {"i": "EC:3.5.1.18", "l": "\"succinyl-diaminopimelate desuccinylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388468", "l": "AVP(20-28) binds AVPR1A,B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9823934", "l": "OPTN binds TBK1 within the activated TLR4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51341", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => 10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57383", "l": "(S)-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] <=> (13S,14R)-1,13-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010487", "l": "thermospermine synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methioninamine + spermidine = S-methyl-5'-thioadenosine + thermospermine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807872", "l": "Active ARF recruits coatomer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50684", "l": "H2O + N(5)-phenyl-L-glutamine = aniline + H(+) + L-glutamate", "d": [], "t": []}, {"i": "EC:3.5.1.123", "l": "\"gamma-glutamylanilide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14903", "l": "casbene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39625", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+) => 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67975", "l": "ATP + ecdysone <=> ADP + ecdysone 22-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264458", "l": "Proteasome mediated degradation of COP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46765", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24341", "l": "(R,R)-butane-2,3-diol + NAD(+) => (R)-acetoin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210935", "l": "Furin cleaves ANTXR1-bound pagA to yield pagA(197-794) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788628", "l": "p-Y-STATs dissociate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852324", "l": "GTSE1 binds PLK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30113", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-enterobactin + H(+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57452", "l": "L-glutaminyl-[protein] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70959", "l": "D-tyrosine + H2O + O2 = 3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33509", "l": "(2E)-hexadecenal + phosphoethanolamine => sphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804276", "l": "ATM phosphorylates TTC5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16873", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20832", "l": "ATP + guanine(out) + H2O = ADP + guanine(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.6.2.6", "l": "\"ABC-type guanine transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173631", "l": "Activation of C1s (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14340", "l": "3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate <=> adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51113", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52219", "l": "[(1''->2')-ADP-alpha-D-ribose](n) + H2O <=> [(1''->2')-ADP-alpha-D-ribose](n-1) + ADP-D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50307", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69651", "l": "cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662660", "l": "Dopachrome is transformed to DHICA by DCT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69849", "l": "a uridine in RNA + H(+) + NADPH => a 5,6-dihydrouridine in RNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8847537", "l": "RAB43:GTP binds USP8NL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9860292", "l": "Activated IKBKB phosphorylates IRF5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3781023", "l": "PPP1R3C binds to glycogen:GYG1:GYS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36397", "l": "7-dehydrodesmosterol + H(+) + NADPH => 7-dehydrocholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627107", "l": "XIAP binds CASP7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14393", "l": "N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.301", "l": "\"cypemycin N-terminal methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37377", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51635", "l": "all-trans-(4S)-hydroxyretinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-(4S,16)-dihydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34154", "l": "3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine <=> 2-deoxystreptamine + 2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821486", "l": "HCFC1 binds SET1A complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68948", "l": "esculetin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9796626", "l": "MIB2 ubiquitinates CFLAR  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26104", "l": "(2R)-homocitrate <=> cis-homoaconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32831", "l": "an R-cob(III)alamin(in) = an R-cob(III)alamin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0120020", "l": "cholesterol transfer activity", "d": ["Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044012", "l": "histone H2AK9 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451900", "l": "IL2RB binds JAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37996", "l": "all-trans-nonaprenyl diphosphate + H(+) + homogentisate => 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954082", "l": "E2F6 binds the PRC1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14327", "l": "daphnin + H(+) + UDP => 7,8-dihydroxycoumarin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10440", "l": "D-glucono-1,5-lactone + H2O = D-gluconate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.17", "l": "\"gluconolactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215406", "l": "PRMT5 binds WDR77 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390641", "l": "ADRA1A,B,D bind ADR,NAd (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64585", "l": "2-hydroxyethane-1-sulfonate(out) + Na(+)(out) => 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55667", "l": "2 AH2 + echinenone + 2 O2 <=> 2 A + canthaxanthin + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70241", "l": "PCK1 phosphorylates OA to yield PEP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8943041", "l": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732822", "l": "nsp3 binds to PLpro inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11300", "l": "1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.143", "l": "\"sequoyitol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021953", "l": "GAMT gene expression is stimulated by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.67", "l": "\"cis-muuroladiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54063", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2Z,6E)-hedycaryol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031704", "l": "apelin receptor binding", "d": ["Binding to an apelin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53534", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64811", "l": "acetyl-CoA + O-(2-aminoethyl)-L-serine <=> CoA + H(+) + O-(2-acetamidoethyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59560", "l": "H2O + N,N',N''-triacetylchitotriono-1,5-lactone = H(+) + N,N',N''-triacetylchitotrionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047986", "l": "hydrogen-sulfide S-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + S(2-) = CoA + thioacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429036", "l": "SLC2A9 transports Fru, Glc, urate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805638", "l": "KAT6A acetylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983152", "l": "Transfer of ubiquitin from E1 to E2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34074", "l": "trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665659", "l": "RAC1:GTP:FMNL1 binds profilin:G-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864989", "l": "TFAP2A homodimer binds the TGFA gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25536", "l": "ent-copalyl diphosphate = diphosphate + ent-sandaracopimara-8(14),15-diene", "d": [], "t": []}, {"i": "EC:4.2.3.29", "l": "\"ent-sandaracopimaradiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64815", "l": "acetyl-CoA + S-(2-aminoethyl)-homocysteine <=> CoA + H(+) + S-(2-acetamidoethyl)-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71306", "l": "D-ribulose 5-phosphate <=> ribose 5-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085028", "l": "GNE phosphorylates ManNAc to ManNAc-6-P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14351", "l": "an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP => an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020262", "l": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28668", "l": "H(+) + hydroxyacetone + NADH => (S)-propane-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866269", "l": "ARRB bind GPCRs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59196", "l": "holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP = AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653974", "l": "Ragulator binds Rag dimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70111", "l": "6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62984", "l": "H2O + hexadecanamide = hexadecanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49869", "l": "(+)-dehydrodiconiferyl acid + a quinone => (+)-dehydrodiconiferyl acid ketone + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40140", "l": "(9Z)-octadecenoyl-CoA + H2O => (9Z)-octadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42820", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin A2 = H2O + 2 NADP(+) + tetracenomycin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112514", "l": "JAK activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102195", "l": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + D-lysinium(1+) + ATP = UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-D-lysine + ADP + hydrogenphosphate + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216045", "l": "Collagen type I binds integrin alpha11beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188979", "l": "Digestion of linear starch (amylose) by extracellular amylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684140", "l": "ATM phosphorylates RBBP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110360", "l": "Recruitment of POLB to the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18925", "l": "L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.20", "l": "\"glucuronolactone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827867", "l": "Expression of TFAP2C in primordial germ cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016977", "l": "chitosanase activity", "d": ["Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0051766", "l": "inositol trisphosphate kinase activity", "d": ["Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41932", "l": "H2O + hexadecanoyl-[ACP] = H(+) + hexadecanoate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72922", "l": "4-O-demethylbarbatate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42887", "l": "(R)-mevalonate + ATP <=> (R)-3-phosphomevalonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.45", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47609", "l": "3-(3-hydroxyphenyl)-propanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3,3',5-trihydroxybibenzyl + 4 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.6", "l": "\"hydroxyacylglutathione hydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917696", "l": "Cargo Sequestration (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34170", "l": "2,6-dihydroxypseudooxynicotine + H2O <=> 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10819", "l": "H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside <=> L-fucose + methyl beta-D-galactoside", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60085", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) => a 4alpha-methyl-3-oxosteroid + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11082", "l": "phosphate + thymidine => dTMP + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852716", "l": "Thrombin, ELANE cleave C5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693356", "l": "CEMIP hydrolyses HA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28784", "l": "H2O + L-cysteinylglycine => glycine + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70279", "l": "H2O + stachyose = D-galactose + raffinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14315", "l": "1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine => 2-iodophenol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49894", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate + H2O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71784", "l": "3-methyl-2-oxobutanoate(out) + H(+)(out) => 3-methyl-2-oxobutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13553", "l": "alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.6", "l": "\"galactokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22418", "l": "catechol + CO2 => 3,4-dihydroxybenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161917", "l": "ALOX5 oxidises 15S-HpETE to LXA4/B4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65173", "l": "(3Z,5E)-dodecadienoyl-CoA + H2O => (3Z,5E)-dodecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30309", "l": "formaldehyde + H2O + NADP(+) + xanthine => 7-methylxanthine + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44449", "l": "an acyl-CoA + H(+) + malonyl-[ACP] => a 3-oxoacyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44709", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58441", "l": "N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N,N-trimethyl-glycyl-L-lysyl-L-glutamyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31003", "l": "(S)-2,3-epoxysqualene = germanicol", "d": [], "t": []}, {"i": "EC:5.4.99.34", "l": "\"germanicol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45069", "l": "(R)-carnitine + an acyl-CoA => CoA + O-acyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52064", "l": "13-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948034", "l": "FGR binds LDL:LRP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848316", "l": "IL36 binds IL1RL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5444516", "l": "Formation of MSH2:MSH6 Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30756", "l": "ATP + carbamate => ADP + carbamoyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664268", "l": "Opsonized leishmania amastigote binds FCGR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49375", "l": "H(+) + NADH + O2 + protodeoxyviolaceinate <=> H2O + NAD(+) + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50892", "l": "a menaquinone + 2 H(+) + hydrogen sulfide + sulfite = a menaquinol + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13556", "l": "alpha-D-galactose + ATP <=> ADP + alpha-D-galactose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190326", "l": "Autocatalytic phosphorylation of FGFR4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168635", "l": "PRKCB (PKC-beta) phosphorylates CARMA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202437", "l": "Phosphorylation of CARMA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75364", "l": "thymidine(in) => thymidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51274", "l": "CoA + H(+) + N-(9Z-octadecenoyl)glycine => (9Z)-octadecenoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42473", "l": "dibenzo-p-dioxin + NADH + O2 => 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45399", "l": "H2O + N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> (9Z)-octadecenoate + H(+) + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210805", "l": "Removal of miRNA passenger strand (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48861", "l": "18-HEPE + O2 => (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59399", "l": "L-leucine <=> D-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851550", "l": "NTPDase8 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44945", "l": "1-O-alkyl-3-acyl-sn-glycerol + H2O => 1-O-alkyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78011", "l": "a 1,3-diacyl-2-(9Z,12Z-octadecadienoyl)-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine = a 1,3-diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32799", "l": "urea(in) = urea(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45770", "l": "L-alaninol + L-glutamate => gamma-L-glutamyl-L-alaninol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38607", "l": "2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75154", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> diphosphate + neoverrucosan-5beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74607", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-galactosamine(out) = UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45508", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] = (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706720", "l": "SARS-CoV-1 E transports Ca2+  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432607", "l": "VRI replaces PDP1 as binder to Clk and cry genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60354", "l": "CO + H(+) + N-octanoylanthranilate => 2-heptyl-3-hydroxy-4(1H)-quinolone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53110", "l": "2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine => 2-hydroxyestrone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47123", "l": "docosanoate + glycine <=> H2O + N-docosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374662", "l": "Translocation of Ezrin to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66678", "l": "4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate => (2E,6E)-farnesyl diphosphate + 5,7-dihydroxy-4-methylphthalide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65946", "l": "3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine => AH2 + CTP + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58000", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose = (20S)-ginsenoside Rg3 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22021", "l": "ATP + H2O + molybdate(out) => ADP + H(+) + molybdate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77515", "l": "3-methoxybenzaldehyde + hydrogen cyanide = (2S)-2-hydroxy-2-(3-methoxyphenyl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70164", "l": "H(+)(in) + methotrexate(in) => H(+)(out) + methotrexate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050216", "l": "propanediol-phosphate dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + propane-1,2-diol 1-phosphate = H+ + hydroxyacetone phosphate + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174157", "l": "Degradation of multiubiquitinated Cyclin B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19150", "l": "L-arginyl-[protein] + NAD(+) => H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27923", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 => 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31881", "l": "beta-seco-amyrin => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213201", "l": "Formation of collagen fibres (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35157", "l": "(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one => (S)-4,5-dihydroxypentane-2,3-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32217", "l": "(6S)-NADHX => (6R)-NADHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432487", "l": "CWO binds to cwo gene and represses transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250280", "l": "ROS oxidize thioredoxin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68396", "l": "a percarboxylic acid + H2O = a carboxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9634861", "l": "NPAS4 binds ARNT2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9861667", "l": "DLAT trimer transfers acetyl to CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31319", "l": "(2R)-3-phosphoglycerate + UDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769011", "l": "NPAS4 binds GEM gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-419645", "l": "Dimerization of LIMK1 by Hsp90 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78426", "l": "D-glucosamine(out) <=> D-glucosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11574", "l": "chenodeoxycholate + FADH2 => FAD + H(+) + H2O + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55863", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391935", "l": "DP1 receptor can bind PGD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052665", "l": "tRNA (uracil-2'-O-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13871", "l": "3-(4-hydroxyphenyl)pyruvate + CO2 + NADH => NAD(+) + prephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607002", "l": "Activated protein C cleaves factor VIIIa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58105", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651992", "l": "PCNA-containing replication complex binds damaged dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35013", "l": "D-fucose(out) + H(+)(out) => D-fucose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20414", "l": "glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine => glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022396", "l": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-43) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10803", "l": "diphosphate + XMP <=> 5-phospho-alpha-D-ribose 1-diphosphate + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1564169", "l": "Collagen type VIII degradation by MMP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59123", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate + H(+) <=> 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15371", "l": "2-carboxy-cis,cis-muconate + 2 H(+) => 2,3-dihydroxybenzoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23628", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.65", "l": "\"3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24746", "l": "L-methionine = 2-aminobut-2-enoate + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250217", "l": "ARL2:GTP binds ARL2BP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34068", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate => diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327738", "l": "DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70361", "l": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.3.17", "l": "\"guanidinopropionase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47726", "l": "5-oxo-L-proline + L-cysteinylglycine => glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9727607", "l": "MME:Zn2+ binds sacubitrilat (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.14", "l": "\"chlorophyllase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57131", "l": "H2O + 2 oxidized [azurin] + tyramine <=> (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55363", "l": "11-cis-retinol <=> 9-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37141", "l": "1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12100", "l": "1,5-anhydro-D-fructose = H2O + microthecin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57051", "l": "AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065966", "l": "SREBP1A,1C,2 binds the TM7SF2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57592", "l": "(S)-pinocembrin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxypinocembrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.80", "l": "\"streptogrisin A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15516", "l": "ATP + keto-D-tagatose <=> ADP + H(+) + keto-D-tagatose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351876", "l": "Caspase-mediated cleavage of occludin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71476", "l": "H2O + neurotensin => L-isoleucyl-L-leucine + neurotensin(1-11)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.2", "l": "\"glutaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19343", "l": "H2O + octan-1-ol + 2 oxidized [rubredoxin] => 2 H(+) + O2 + octane + 2 reduced [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32661", "l": "(6E)-8-oxogeranial + 2 H(+) + 2 NADPH => (6E)-8-hydroxygeraniol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047948", "l": "glutarate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + glutarate = ADP + glutaryl-CoA + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003855", "l": "3-dehydroquinate dehydratase activity", "d": ["Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140945", "l": "histone H3K4 monomethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl4-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693198", "l": "RHOD binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44506", "l": "a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate => 4-hydroxybenzoate + an all-trans-polyprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247960", "l": "Activation of p38 MAPK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.3", "l": "\"uridine phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202365", "l": "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937050", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008489", "l": "UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity", "d": ["Catalysis of the reaction: a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73365", "l": "beta-alanyl-dopamine + H(+) + holo-[peptidyl-carrier protein] => beta-alanyl-[peptidyl-carrier protein] + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68224", "l": "2-oxoglutarate + H(+) + O2 + prekainate = CO2 + H2O + kainate lactone + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140809", "l": "histone H4R3 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H4 L-arginyl (position 3)= histone H4 L-citrullyl (position 3) + NH4+, resulting in histone H4 citrullination at position 3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79009", "l": "3-diazo-4-hydroxybenzoate + AMP + diphosphate + H2O => 3-amino-4-hydroxybenzoate + ATP + H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.147", "l": "\"acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21644", "l": "ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.30", "l": "\"glycerol kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15054", "l": "(6R)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44494", "l": "3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine => 3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2569057", "l": "RIP3 binds TRIF to mediate necroptosis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18465", "l": "L-dopa + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.30", "l": "\"stizolobinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9822539", "l": "VWF multimer binds to collagen type I (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50511", "l": "acetyl-CoA + N-terminal L-valyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941701", "l": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210290", "l": "Interaction of PECAM-1 and SHIP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132271", "l": "Factor H displaces Bb in Cb:Bb complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833388", "l": "MAVS and DDX58 interact (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047036", "l": "codeinone reductase (NADPH) activity", "d": ["Catalysis of the reaction: codeine + NADP+ = codeinone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76478", "l": "hexadecan-1-ol + O2 <=> H2O2 + hexadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40919", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79141", "l": "H2O + L-serocholate => cholate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18264", "l": "H2O + precorrin-5 + S-adenosyl-L-methionine <=> acetate + 2 H(+) + precorrin-6A + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34605", "l": "CoA + H(+) + N-acyl-15-methylhexadecasphinganine => 15-methylhexadecasphinganine + a fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53090", "l": "2-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38417", "l": "(9Z,12Z,15Z)-octadecatrienoate + 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + H(+) => 1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-532549", "l": "MPI isomerises Fru6P to Man6P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73771", "l": "O2 + preechinulin + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + neoechinulin A + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66144", "l": "5-methoxytryptamine + acetyl-CoA = CoA + H(+) + melatonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689317", "l": "Formation of the pre-incision complex in GG-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21937", "l": "carbamoyl phosphate + putrescine => H(+) + N-carbamoylputrescine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59324", "l": "D-xylose + O2 = D-xylono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78838", "l": "3''-dehydropuerarin <=> 1,5-anhydro-D-erythro-hex-1-en-3-ulose + daidzein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60297", "l": "L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10679", "l": "(2R,3S)-3-isopropylmalate <=> 2-isopropylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601929", "l": "Unknown nuclease cleaves cleaved transposon RNA in 6xMeR-PIWIL2:cleaved transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69053", "l": "RFC binding displaces Pol Alpha (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20386", "l": "(2R,3R)-dihydroquercetin + H(+) + NADH + O2 => (2R,3R)-2,3-dihydrogossypetin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102549", "l": "1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + H2O = sn-1-lyso-2-16:0-monogalactosyldiacylglycerol + oleate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2203480", "l": "COLEC11 binds ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37925", "l": "(8E,10S,12Z,15Z)-10-hydroperoxyoctadeca-8,12,15-trienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76682", "l": "CoA + NAD(+) + sulfoacetaldehyde <=> H(+) + NADH + sulfoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432010", "l": "Aquaporin-1 passively transports water into cell (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16566", "l": "2-oxoglutarate + L-histidine => 3-(imidazol-5-yl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617829", "l": "Assembly of IFT A complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17934", "l": "a 7-hydroxyisoflavone + S-adenosyl-L-methionine => a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016762", "l": "xyloglucan:xyloglucosyl transferase activity", "d": ["Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174731", "l": "Degradation of newly synthesized ApoB-48 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50182", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71934", "l": "fumarate(out) + 3 Na(+)(out) <=> fumarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78080", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => a 1-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-593685", "l": "Netrin-4 binds DCC/UNC5A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350901", "l": "Iodide is organified (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51081", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18568", "l": "19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine <=> 9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22564", "l": "a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696491", "l": "CNTF binds CNTFR complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64818", "l": "5-aminolevulinate(out) => 5-aminolevulinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653936", "l": "Formation of Ragulator complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76894", "l": "2-hydroxy-1-phenylethan-1-amine + H2O + NAD(+) <=> 2-hydroxyacetophenone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.923250621671642", "identifiers": [{"i": "GO:0005228", "l": "intracellular sodium-activated potassium channel activity", "d": ["Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20486", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418553", "l": "cAMP degradation by Phosphodiesterases (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73067", "l": "an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O = an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]", "d": [], "t": []}, {"i": "EC:3.2.1.96", "l": "\"mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63232", "l": "(2E)-octenoyl-CoA + H(+) + NADH = NAD(+) + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174202", "l": "Degradation of multiubiquitinated Securin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250280", "l": "ROS oxidize thioredoxin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70802", "l": "L-lysine(in) + L-ornithine(out) <=> L-lysine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607722", "l": "Active NIK phosphorylates IKKA dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5687640", "l": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45553", "l": "H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3234084", "l": "SUMOylation of TFAP2B with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13788", "l": "(3S)-citramalyl-CoA <=> H2O + itaconyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57769", "l": "2-nitrotoluene + NADH + O2 => 3-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37571", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362549", "l": "Hh-Np traffics to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18016", "l": "H2O + N(5)-ethyl-L-glutamine <=> ethylamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45322", "l": "H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine => H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2262743", "l": "Defective IDS does not hydrolyse dermatan sulfate (Chebi:63517 chain) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57402", "l": "acetate + H(+) + narcotine hemiacetal => 3-O-acetylpapaveroxine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853792", "l": "RET tyrosine phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1170539", "l": "Prolactin receptor is internalized (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68728", "l": "26-oxolanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxy-lanosta-8, 24-dien-26-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.35", "l": "\"tissue kallikrein\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54419", "l": "5alpha-campestan-3-one + NADP(+) <=> campest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60195", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 <=> CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.14", "l": "\"ABC-type aliphatic sulfonate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22404", "l": "beta-D-galacturonate + NAD(+) = D-galactaro-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4647594", "l": "SAHF formation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65424", "l": "AMP(in) + NAD(+)(out) = AMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-196773", "l": "COASY phosphorylates DP-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75150", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (-)-cyatha-3,12-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.32", "l": "\"beta-lytic metalloendopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070780", "l": "dihydrosphingosine-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875623", "l": "SLC25A18,22 import L-Glu, H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68652", "l": "2 L-homocysteine = H(+) + hydrogen sulfide + L-homolanthionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66045", "l": "2-oxobutanoate + L-kynurenine => (2S)-2-aminobutanoate + H2O + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41943", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate <=> [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48680", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.330", "l": "\"very-long-chain 3-oxoacyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047186", "l": "N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity", "d": ["Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53314", "l": "16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004417", "l": "hydroxyethylthiazole kinase activity", "d": ["Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58188", "l": "all-trans-lycopene + dimethylallyl diphosphate + H2O = dihydroisopentenyldehydrorhodopin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69206", "l": "ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate => ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1888198", "l": "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034611", "l": "oligoribonucleotidase activity", "d": ["Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63277", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 => a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29288", "l": "2 H(+)(in) + L-aspartate(in) => 2 H(+)(out) + L-aspartate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018794", "l": "RHOV binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72149", "l": "3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine => AH2 + S-adenosyl-L-methionine + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2574845", "l": "AJUBA binds centrosome-associated AURKA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940959", "l": "Neurolysin degrades neurotensin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22423", "l": "cis,trans-4-hydroxymuconate semialdehyde + H2O + NAD(+) <=> 2 H(+) + maleylacetate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696997", "l": "USP24 deubiquitinates DDB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875661", "l": "GGA3 associates with activated MET receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39074", "l": "dodecanedioyl-CoA + O2 <=> (2E)-dodecenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007496", "l": "APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806877", "l": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675417", "l": "PEBP1 binds activated RAF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55404", "l": "[phosphate](n) + UTP = [phosphate](n+1) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948231", "l": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77336", "l": "[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-1-O,3-O-dimethyl-alpha-D-mannose + GDP-alpha-D-mannose => alpha-D-mannosyl-(1->4)-[3-O-methyl-alpha-D-mannosyl-(1->4)](n)-1-O,3-O-dimethyl-alpha-D-mannose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444647", "l": "C3a receptor binds anaphylatoxin C3a (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33262", "l": "4-aminoimidazole + H(+) + 2 H2O <=> N-formimidoylglycine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41771", "l": "a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GT1a (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016690", "l": "diarylpropane peroxidase activity", "d": ["Catalysis of the reaction: (3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980109", "l": "Cleavage of CNTN1:NOTCH1 complex releases NICD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31805", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H(+) + UDP => H2O + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78739", "l": "(3S)-hydroxyoctadecanoyl-CoA + NAD(+) = 3-oxooctadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213195", "l": "Formation of anchoring fibrils (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74915", "l": "a (2E)-enoyl fatty acid + ATP + H(+) = a (2E)-2-fatty-enoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640167", "l": "RRAGA,B exchanges GDP for GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20854", "l": "ADP + 2 H(+)(out) + phosphate => ATP + H(+)(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39900", "l": "7-deoxyloganetin + UDP-alpha-D-glucose => 7-deoxyloganin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30061", "l": "orotate + succinate => (S)-dihydroorotate + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19651", "l": "AMP + diphosphate + L-aspartyl-tRNA(Asp) => ATP + L-aspartate + tRNA(Asp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65945", "l": "AH2 + CTP + S-adenosyl-L-methionine => 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551451", "l": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033777", "l": "lithocholate 6beta-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + lithocholate + NADPH + O2 = 6-beta-hydroxylithocholate + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139920", "l": "Translocation of tBID to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426489", "l": "RISC binds inexactly matching target RNAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203946", "l": "PDK isozymes phosphorylate PDHC subunit E1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70971", "l": "ACO2 isomerizes citrate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21740", "l": "2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + H(+) + hydrogen sulfide + pyruvate", "d": [], "t": []}, {"i": "EC:2.8.1.2", "l": "\"3-mercaptopyruvate sulfurtransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163798", "l": "Furin cleaves pro-protein Z to protein Z (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33859", "l": "(2S-3S)-versiconal hemiacetal = H2O + versicolorin B", "d": [], "t": []}, {"i": "EC:4.2.1.143", "l": "\"versicolorin B synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9855212", "l": "SDHA binds to SDHB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69173", "l": "Joining of adjacent Okazaki fragments (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59535", "l": "(S)-reticuline + S-adenosyl-L-methionine <=> (S)-codamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9702818", "l": "CALCR binds erenumab (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24073", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66148", "l": "2-phenylethylamine + acetyl-CoA = CoA + H(+) + N-(2-phenylethyl)acetamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2509831", "l": "ITPA hydrolyses XTP to XMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20475", "l": "AMP + 2 H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] => (R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44788", "l": "2-demethylmenaquinol-11 + S-adenosyl-L-methionine = H(+) + menaquinol-11 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1250280", "l": "ROS oxidize thioredoxin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13384", "l": "acetate + an acyl-CoA <=> a carboxylate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202241", "l": "Recruitment of SLP-76 to Gads (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617179", "l": "PRKACA phosphorylates TNNI3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4608855", "l": "PRICKLE1 is degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9823910", "l": "Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682285", "l": "ABCA12 transports lipids from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879362", "l": "AGER binds ERK1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404137", "l": "LRAT esterifies RBP1:atROL and FACYLs to atREs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62253", "l": "2 hydrogencarbonate(out) + Zn(2+)(out) => 2 hydrogencarbonate(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58567", "l": "15alpha-stemmadenine + NADP(+) <=> 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196754", "l": "COASY transfers an adenylyl group from ATP to PPANT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001758", "l": "retinal dehydrogenase activity", "d": ["Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51910", "l": "dADP + H(+) + phosphate => dATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59929", "l": "erythritol + NADP(+) => D-erythrose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71130", "l": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5334794", "l": "FABPs bind LCFAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022405", "l": "ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031458", "l": "ABC-type betaine transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2263496", "l": "Defective NAGLU does not hydrolyse Heparan sulfate chain(4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0035240", "l": "dopamine binding", "d": ["Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28154", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847968", "l": "PTEN binds FRK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749505", "l": "LRRC14 binds IKBKB and CHUK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-432074", "l": "Aquaporin-7 passively transports glycerol out of cell (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37969", "l": "D-galactose + H(+) + NADPH => galactitol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64199", "l": "an N-(fatty acyl)-L-lysine + H2O <=> a fatty acid + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9609310", "l": "β-blockers bind ADRB1,2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22259", "l": "a (3R)-3-hydroxyacyl-CoA + NADP(+) <=> a 3-oxoacyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109858", "l": "MAP2K2 binds MAPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769397", "l": "SOST binds LRP5/6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77182", "l": "(5'S,6'R)-C-glycyluridine + O2 <=> CO2 + H2O + uridine-5'-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696457", "l": "BDH2 dehydrogenates 3HBA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46283", "l": "an N-acylsphing-4-enine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17099", "l": "enol-phenylpyruvate => 3-phenylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40605", "l": "(9Z,12Z)-octadecadienoate + glycerol + H(+) => 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14139", "l": "6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + beta-D-galactosyl-(1<->1)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40782", "l": "2-aminopentanenitrile + H(+) + 2 H2O <=> L-2-aminopentanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65516", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O = NH4(+) + pre-mycofactocin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68413", "l": "H2O + L-glutamate 5-semialdehyde + NADP(+) => 2 H(+) + L-glutamate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64582", "l": "diphosphate + nerylneryl diphosphate => (2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46177", "l": "2-methylpropanoate + ATP + CoA => 2-methylpropanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62254", "l": "2 hydrogencarbonate(in) + Zn(2+)(in) => 2 hydrogencarbonate(out) + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42227", "l": "A + testosterone <=> AH2 + androst-4-ene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49303", "l": "D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] <=> alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28018", "l": "enterobactin + 3 H2O = 2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14492", "l": "a nucleoside 2',3'-cyclic phosphate + H2O <=> a nucleoside 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43850", "l": "[thioredoxin]-disulfide + arsenite + H2O => [thioredoxin]-dithiol + arsenate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762091", "l": "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788622", "l": "p-Y-STATs dimerize (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045148", "l": "tripeptide aminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a tripeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981713", "l": "C4b binds to cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24138", "l": "a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+) => 3'-phosphoadenylyl sulfate + a primary amine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30499", "l": "H(+) + N,N-dihydroxy-L-valine = (E)-2-methylpropanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11377", "l": "(19E)-geissoschizine + NADP(+) => 4,21-dehydrogeissoschizine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35918", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043720", "l": "3-keto-5-aminohexanoate cleavage activity", "d": ["Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40398", "l": "1,2-dihydro-beta-NAD + H(+) + O2 <=> H2O2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69053", "l": "RFC binding displaces Pol Alpha (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25144", "l": "3-hydroxy-L-kynurenine + H2O => 3-hydroxyanthranilate + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042608", "l": "T cell receptor binding", "d": ["Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29250", "l": "3 H(+)(out) + 2 Na(+)(in) <=> 3 H(+)(in) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40080", "l": "docosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161959", "l": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52067", "l": "13-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685156", "l": "ATR phosphorylates RPA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762345", "l": "PREDN:ALB dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73789", "l": "diphosphate + variecolorin L => dimethylallyl diphosphate + tardioxopiperazine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29799", "l": "ATP + D-allose(out) + H2O = ADP + D-allose(in) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.5.2.8", "l": "\"ABC-type D-allose transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60021", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + sesquisabinene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9734687", "l": "ORC6 is phosphorylated on T195 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.194", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14565", "l": "(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140407", "l": "L-alanine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28779", "l": "4-hydroxy-L-threonine = glycine + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38440", "l": "(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56691", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 <=> (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1638104", "l": "UGCG transfers glucose to ceramide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835411", "l": "FA core complex:HSP70s binds PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32631", "l": "erythromycin D + H(+) + NADPH + O2 = erythromycin C + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.154", "l": "\"erythromycin 12 hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59860", "l": "3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16883", "l": "2 H(+) + sulfite + thiocyanate => hydrogen cyanide + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45379", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222597", "l": "Loaded mycobactin gets imported (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34093", "l": "(S)-2-amino-6-oxohexanoate + NH4(+) + phosphate => (5R)-5-phosphooxy-L-lysine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62630", "l": "an alcohol + H2O + NAD(+) => a hydroperoxide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654510", "l": "FGFRL1 binds SPRED1/2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0008083", "l": "growth factor activity", "d": ["The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785245", "l": "Defective CYP11B2 does not oxidise CORST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806392", "l": "TP53 stimulates MLH1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4086083", "l": "SUMOylation of ING2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51032", "l": "7-chloroindole-3-pyruvate imine dimer = dichlorochromopyrrolate + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59006", "l": "dodecanoate + H(+) + H2O2 => dodecanal + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190265", "l": "FGFR4 binds to FGF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396234", "l": "Collagen type VII binds laminin-322 and collagen IV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18500", "l": "L-ribulose 5-phosphate <=> L-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69331", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate <=> 5-(methylsulfanyl)pentanenitrile + H(+) + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390663", "l": "ADRA2A,B,C bind ADR,NAd (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64412", "l": "n H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) = n H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67725", "l": "CMP(out) + CMP-N-acetyl-beta-neuraminate(in) => CMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38663", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202164", "l": "Translocation of PDK1 to Plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5336443", "l": "LIN7, CASK and APBA1 bind (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33517", "l": "2 H2O + 2 indole-5,6-quinone => 2 5,6-dihydroxyindole + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74310", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + NAD(+) <=> 12alpha-hydroxy-3-oxochola-4-en-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617483", "l": "HOXA2 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682967", "l": "WHSC1 binds DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53656", "l": "(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 = (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4088220", "l": "Endorepellin binds alpha2beta1 integrin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011313", "l": "Proteasome degrades ubiquitinated ROBO3.1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9706393", "l": "RHOBTB3 binds ATP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29512", "l": "(2E,6E)-farnesyl diphosphate => (+)-valencene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.40", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51281", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1248655", "l": "Trans-autophosphorylation of EGFRvIII mutant dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31774", "l": "an all-trans-retinyl ester + H2O <=> 11-cis-retinol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983156", "l": "Polyubiquitination of substrate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102998", "l": "4-sulfomuconolactone hydrolase activity", "d": ["Catalysis of the reaction: (5-oxo-2-sulfonato-2,5-dihydrofuran-2-yl)acetate + H2O = maleylacetate + sulfite + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55998", "l": "beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => H2O + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035380", "l": "very long-chain-3-hydroxyacyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034907", "l": "acetanilide 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: acetanilide + O2 + 2 H+ + NADH = catechol + NAD+ + acetamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53583", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16977", "l": "acetoacetate + coenzyme M + NADP(+) = 2-oxopropyl-coenzyme M + CO2 + NADPH", "d": [], "t": []}, {"i": "EC:1.8.1.5", "l": "\"2-oxopropyl-CoM reductase (carboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78763", "l": "H2O + N-deacetylipecoside = D-glucose + N-deacetylipecoside aglycone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66371", "l": "6-methyl-3,7-dioxodecanedioyl-CoA + CoA <=> 4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12046", "l": "a diacylglycerol + a fatty acid + H(+) => a triacylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58280", "l": "4 ATP = cyclic tetraadenylate + 4 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35299", "l": "3-hydroxyoctadecanoyl-CoA + NADP(+) = 3-oxooctadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66374", "l": "glycerol + phosphate => H2O + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3209165", "l": "ID1 sequesters ETS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990381", "l": "ubiquitin-specific protease binding", "d": ["Binding to a ubiquitin-specific protease."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395876", "l": "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683593", "l": "ATG7:ATG3:LC3 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29454", "l": "H2O + phosphonate <=> H2 + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981931", "l": "RAC1 and CDC42 activate PAK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29664", "l": "H(+)(in) + xanthine(in) => H(+)(out) + xanthine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49438", "l": "choloyl-CoA + deoxycholate => cholate + deoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69087", "l": "acrolein + H2O + NAD(+) <=> acrylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35525", "l": "N-ethylsuccinimide + NADP(+) => H(+) + N-ethylmaleimide + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9699581", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379387", "l": "COMT transfers Met to DA to form 3MT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373747", "l": "Phosphorylation of nephrin by FYN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60378", "l": "D-glucose(in) => D-glucose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24737", "l": "2-oxoglutarate + 4-hydroxybutanoate <=> (R)-2-hydroxyglutarate + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65239", "l": "3-methylbutanol + acetyl-CoA <=> 3-methylbutyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001605", "l": "adrenomedullin receptor activity", "d": ["Combining with adrenomedullin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34091", "l": "(5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.134", "l": "\"5-phosphooxy-L-lysine phospho-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42947", "l": "cytidine(40) in tRNA precursor + S-adenosyl-L-methionine <=> 5-methylcytidine(40) in tRNA precursor + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9844587", "l": "GAL3ST1 transfers sulfate to GalCer,LacCer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.507798223252038", "identifiers": [{"i": "GO:0016877", "l": "ligase activity, forming carbon-sulfur bonds", "d": ["Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}, {"i": "EC:6.2.-.-", "l": "\"Forming carbon-sulfur bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68595", "l": "ORC2 binds ORC3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70119", "l": "6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60063", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30658", "l": "ATP + dUMP <=> ADP + dUDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25687", "l": "H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) => L-cysteinyl-tRNA(Cys) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44438", "l": "a triacylglycerol + glycerol => a 1,2-diacylglycerol + a 1-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008273", "l": "calcium, potassium:sodium antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047888", "l": "fatty acid peroxidase activity", "d": ["Catalysis of the reaction: 2 H2O2 + H+ + palmitate = CO2 + 3 H2O + pentadecanal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63576", "l": "ecdysone 22-phosphate + H2O = ecdysone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694287", "l": "Cleavage of S protein into S1:S2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730842", "l": "PI3K associates with phosphorylated GAB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873850", "l": "STARD5 binds DCA, LCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679775", "l": "COMT binds COMT Inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857549", "l": "HBEGF-bound EGFR forms a heterodimer with GPNMB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008929", "l": "methylglyoxal synthase activity", "d": ["Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31168", "l": "(3S)-hydroxytetradecanoyl-CoA + NAD(+) => 3-oxotetradecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428750", "l": "Gq activation by TP receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54730", "l": "malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985943", "l": "p-Y701-STAT1 dimerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381644", "l": "ER calcium channels open in response to activated PKA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54178", "l": "a long-chain fatty acyl-[ACP] + H(+) + NADPH => a long-chain fatty aldehyde + holo-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874145", "l": "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212614", "l": "Glutamine transport from astrocytes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70711", "l": "D-alanine(in) = D-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19073", "l": "ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein]", "d": [], "t": []}, {"i": "EC:2.7.11.10", "l": "\"IkappaB kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140416", "l": "transcription regulator inhibitor activity", "d": ["A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120022", "l": "glucagon family peptide binding", "d": ["Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46004", "l": "2-methylpropanal + CoA + NAD(+) = 2-methylpropanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296304", "l": "GPR31 is a receptor for 12(S)-HETE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70885", "l": "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42785", "l": "adenosine(2085) in 23S rRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(6)-dimethyladenosine(2085) in 23S rRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78775", "l": "3''-dehydroisovitexin = 1,5-anhydro-D-erythro-hex-1-en-3-ulose + apigenin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048495", "l": "Roundabout binding", "d": ["Binding to Roundabout (ROBO) receptor, a transmembrane receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848395", "l": "IL18:IL18R1 binds IL18RAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58121", "l": "ATP + L-seryl-[protein] => 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21209", "l": "H2O + O-phospho-L-serine => L-serine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15098", "l": "5-formimidoyltetrahydrofolate + L-glutamate => (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69255", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate <=> 2-(thiiran-2-yl)acetonitrile + sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28778", "l": "dinoflagellate luciferin + O2 <=> H(+) + H2O + hnu + oxidized dinoflagellate luciferin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25027", "l": "NH4(+) + S-methyl-5'-thioinosine => H(+) + H2O + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12936", "l": "L-fuculose 1-phosphate <=> (S)-lactaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66917", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate => 9-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086410", "l": "CDK1 phosphorylates BORA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36441", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36690", "l": "hexadecanoyl-CoA + sphing-4-enine <=> CoA + H(+) + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37263", "l": "ATP + H2O + L-alanyl-L-aspartate(out) = ADP + H(+) + L-alanyl-L-aspartate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36369", "l": "2-hydroxyglutarate + H(+) => (S)-alpha-hydroxyglutarate-gamma-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36831", "l": "2 caldariellaquinol + n H(+)(in) + O2 = 2 caldariellaquinone + n H(+)(out) + 2 H2O", "d": [], "t": []}, {"i": "EC:7.1.1.4", "l": "\"caldariellaquinol oxidase (H(+)-transporting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-421007", "l": "Endocytosis of Ca impermeable AMPA receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63502", "l": "NADP(+) + sulfinamide glutathione => H(+) + NADPH + S-nitrosoglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12256", "l": "L-arogenate + NAD(+) = CO2 + L-tyrosine + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38058", "l": "CTP + phytol <=> CDP + H(+) + phytyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1013013", "l": "Association of GABA B receptor with G protein beta-gamma subunits (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850818", "l": "SPINK9 binds KLK5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-451634", "l": "NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73428", "l": "genkwanin + O2 + reduced [NADPH--hemoprotein reductase] => H2O + oxidized [NADPH--hemoprotein reductase] + scutellarein 7-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43151", "l": "adenosine(9) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyladenosine(9) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29985", "l": "cytidine(out) + H(+)(out) => cytidine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202604", "l": "Formation of a heteromeric BMP receptor complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836664", "l": "p-PKR dimer phosphorylates PPP2R5A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007591", "l": "E2F6 binds RRM2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655193", "l": "KIAA0101 double monoubiquitination (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005464", "l": "UDP-xylose transmembrane transporter activity", "d": ["Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate."], "t": []}, {"i": "REACT:R-HSA-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.4.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24314", "l": "H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine => L-lysyl-[cytochrome c] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46659", "l": "androst-4-ene-3,17-dione + H(+) + NADPH <=> 5beta-androstane-3,17-dione + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080067", "l": "4-methylthiobutyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 4-methylthiobutyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 4-methylthiobutyl-glucosinolate + adenosine 3',5'-bisphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950518", "l": "STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809320", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45845", "l": "(3R)-hydroxyoctanoyl-CoA + NADP(+) => 3-oxooctanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3134800", "l": "STING dimerization (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52192", "l": "(E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase] = (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42568", "l": "2,3-dihydroxy-p-cumate + O2 = 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653503", "l": "KRAS4B is phosphorylated on serine 181 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27891", "l": "3'-UMP + H2O => phosphate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692495", "l": "BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617641", "l": "MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229283", "l": "LCNs bind lipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40933", "l": "(3S)-3-hydroxy-L-ornithine + CO2 + succinate => 2-oxoglutarate + L-ornithine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51086", "l": "16,17-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51299", "l": "a quinone + H2O + L-methionyl-[protein] <=> a quinol + L-methionyl-(R)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1250280", "l": "ROS oxidize thioredoxin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12229", "l": "ATP + H2O + L-aspartate + L-glutamine => AMP + diphosphate + H(+) + L-asparagine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15870", "l": "2-oxoglutarate + D-alanine => D-glutamate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39864", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034281", "l": "ent-isokaurene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50039", "l": "choloyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47268", "l": "bacterioruberin = H2O + monoanhydrobacterioruberin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69895", "l": "cytidine(out) + Na(+)(out) = cytidine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214871", "l": "Phosphorylated CACT is degraded in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24137", "l": "3'-phosphoadenylyl sulfate + a primary amine => a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114256", "l": "CYCS:APAF1 binds procaspase-9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25931", "l": "3-methylquinoline + A + H2O <=> 3-methylquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30801", "l": "acetoacetyl-CoA + H(+) + NADH => (3S)-3-hydroxybutanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085372", "l": "PIAS1 SUMOylates SAFB with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64773", "l": "S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine => 2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72746", "l": "leukotriene C4(out) <=> leukotriene C4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12607", "l": "1-deoxy-D-xylulose 5-phosphate + CO2 => D-glyceraldehyde 3-phosphate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0140824", "l": "thioredoxin-dependent peroxiredoxin activity", "d": ["Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836702", "l": "PKR inhibitors bind PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42054", "l": "9-cis-retinal + H(+) + NADH => 9-cis-retinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56093", "l": "(4Z,15Z)-bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75459", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39512", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA => (2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63006", "l": "(11Z,14Z)-eicosadienoate + NH4(+) => (11Z,14Z)-eicosadienamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56135", "l": "(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine in DNA <=> a thymidine dimer in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74726", "l": "Dissociation of insulin from insulin receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32725", "l": "(E)-6-(methylsulfanyl)hexanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-trihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24405", "l": "(3S)-hydroxy-3-methylglutaryl-CoA => acetoacetate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26157", "l": "D-mannose + NADP(+) => 2-dehydro-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202241", "l": "Recruitment of SLP-76 to Gads (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32375", "l": "limonene-1,2-diol + NAD(+) = 1-hydroxylimonen-2-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24932", "l": "H2O + L-cysteine => H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016985", "l": "mannan endo-1,4-beta-mannosidase activity", "d": ["Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9707856", "l": "PGRMC2:Hemes dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004358", "l": "glutamate N-acetyltransferase activity", "d": ["Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877941", "l": "RUNX2 binds SMAD1 in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0036318", "l": "peptide pheromone receptor activity", "d": ["Combining with a peptide pheromone, and transmitting the signal across the membrane to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390459", "l": "Exchange of ADP for ATP in CCT/TriC:actin complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12483", "l": "5-aminolevulinate + pyruvate <=> 4,5-dioxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12752", "l": "3,4,5-trihydroxybenzoate + H(+) <=> 1,2,3-trihydroxybenzene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3296326", "l": "HCAR1 binds LACT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41693", "l": "1-O-hexadecyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36208", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an acyl-CoA => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64883", "l": "CDP + H2O <=> CMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20037", "l": "D-sorbitol 6-phosphate + NADP(+) = aldehydo-D-glucose 6-phosphate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.200", "l": "\"aldose-6-phosphate reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74532", "l": "AH2 + archaetidylglycerol + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaetidylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65763", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683964", "l": "ATM phosphorylates EYA1-4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28479", "l": "galactarate(in) + H(+)(in) => galactarate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68870", "l": "AMP + benzaldehyde + diphosphate + NADP(+) => ATP + benzoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2396009", "l": "STING binds c-di-GMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5675417", "l": "PEBP1 binds activated RAF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46223", "l": "androst-5-en-3beta,17beta-diol + NAD(+) <=> 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21388", "l": "H2O + L-2-aminohexano-6-lactam = L-lysine", "d": [], "t": []}, {"i": "EC:3.5.2.11", "l": "\"L-lysine-lactamase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913456", "l": "Interleukin-5 receptor alpha subunit binds Interleukin-5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0051752", "l": "phosphoglucan, water dikinase activity", "d": ["Catalysis of the reaction: ATP + [phospho-alpha-glucan] + H2O = AMP + O-phospho-[phospho-alpha-glucan] + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55496", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708525", "l": "BACH1:FBXL17 binds SCF(SKP2) complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39081", "l": "3-oxododecanedioyl-CoA + H(+) + NADH => (3S)-hydroxydodecanedioyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209536", "l": "IkB is ubiquitinated and degraded (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876446", "l": "p-ULK1 phosphorylates DENND3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044605", "l": "phosphocholine transferase activity", "d": ["Catalysis of the reaction: CDP-choline + protein-serine = CMP + protein-serine-choline phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24570", "l": "an alcohol + D-galactose 6-phosphate => a 6-phospho-beta-D-galactoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9609310", "l": "β-blockers bind ADRB1,2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350359", "l": "RHO1:GDP complex dissociates from RHOGDI and binds to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183072", "l": "EGFR non-clathrin mediated endocytosis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11809", "l": "bergaptol + S-adenosyl-L-methionine => bergapten + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.53", "l": "\"methylenetetrahydrofolate reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825774", "l": "SNAI2 and TBX3 repress CDH1 gene expression during melanocyte development (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68338", "l": "(R)-pantetheine sulfonate + phosphate => (R)-4'-phosphopantetheine sulfonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33086", "l": "dehypoxanthine futalosine + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71180", "l": "L-histidine(out) + L-tryptophan(in) => L-histidine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0000993", "l": "RNA polymerase II complex binding", "d": ["Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086076", "l": "gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9770141", "l": "Formation of the Spliceosomal C* complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.1", "l": "\"deoxyribonuclease II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24979", "l": "(1S)-1,25-dihydroxy-24-oxocalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1,23,25-trihydroxy-24-oxocalciol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77051", "l": "3,5-dimethylcyclohexanamine + H2O + NADP(+) = 3,5-dimethylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50735", "l": "4-hydroxyphenylacetonitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-4-hydroxymandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43066", "l": "holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322427", "l": "Beta-catenin recruits CBP/p300 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65509", "l": "3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidin-2-one + H2O + O2 => H2O2 + NH4(+) + pre-mycofactocin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43519", "l": "2-carboxy-5-formylfuran + H2O <=> 2-carboxy-5-(dihydroxymethyl)furan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858270", "l": "HILPDA binds lipid droplets (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805811", "l": "Release of SEPT4 from mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.4", "l": "\"tripeptide aminopeptidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.145", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68627", "l": "phycoerythrobilin-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(82)-[C-phycoerythrin alpha-subunit]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70979", "l": "MDH2 dimer dehydrogenates MAL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193997", "l": "CYP11B1 oxidises 11DCORT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.39", "l": "\"hydroxyjasmonate sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73013", "l": "L-leucine(out) => L-leucine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.185", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9835189", "l": "NCK1 binds PKR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35269", "l": "ethanol(out) => ethanol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28050", "l": "H2O + NADP(+) = NAD(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863858", "l": "SEC22B, CALR, STX4, TAP and TAPBP bind (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33597", "l": "CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75731", "l": "(10S)-hydroxy-(12Z)-octadecenoate + NAD(+) = 10-oxo-(12Z)-octadecenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35775", "l": "L-glutamine + UDP-3-oxo-alpha-D-glucose = 2-oxoglutaramate + UDP-alpha-D-kanosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56370", "l": "3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+) => 3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34981", "l": "H(+)(out) => H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015366", "l": "malate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.26", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69068", "l": "RFC dissociates after sliding clamp formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31011", "l": "(S)-2,3-epoxysqualene = camelliol C", "d": [], "t": []}, {"i": "EC:5.4.99.38", "l": "\"camelliol C synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67742", "l": "aceneuramate => N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663174", "l": "p-BMAL1:p-CLOCK,NPAS2 binds PER1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74033", "l": "L-alanine(out) + L-cysteine(in) => L-alanine(in) + L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24731", "l": "anthranilate + H(+) => aniline + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10155", "l": "ATP + hydrogencarbonate + NH4(+) <=> ADP + carbamoyl phosphate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11916", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31380", "l": "H2O + pyrrole-2-carboxylate => 1H-pyrrole + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046702", "l": "galactoside 6-L-fucosyltransferase activity", "d": ["Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10998", "l": "2-methylpropanal O-methyloxime + H(+) + S-adenosyl-L-homocysteine => 2-methylpropanal oxime + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034256", "l": "chlorophyll(ide) b reductase activity", "d": ["Catalysis of the reaction: 71-hydroxychlorophyll(ide) a + NAD(P)+ = chlorophyll(ide) b + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.101", "l": "\"L-proline amide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12219", "l": "9H-fluoren-9-ol + NAD(+) <=> 9H-fluoren-9-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15432", "l": "heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785762", "l": "IL13RA1 binds TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53577", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41891", "l": "3-oxotetradecanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75158", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> diphosphate + verrucosan-2beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.18", "l": "\"glucuronate-2-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445700", "l": "Myosin Binds ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799178", "l": "Intermediate 1 binds HP subcomplex to form Intermediate 2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607058", "l": "Activated protein C:PROCR binds F2R (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396009", "l": "STING binds c-di-GMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9824732", "l": "G or G analog binds C-ter TLR7 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047010", "l": "hydroxycyclohexanecarboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD+ = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44399", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36968", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.49", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72502", "l": "2-oxoglutarate(in) + prostaglandin E2(out) <=> 2-oxoglutarate(out) + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72130", "l": "agmatine(in) + H(+)(out) <=> agmatine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871260", "l": "YAP1 binds TEAD2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043682", "l": "P-type divalent copper transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47942", "l": "a ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine => a ganglioside GM2 (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55348", "l": "all-trans-retinol = 9-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64887", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + UMP <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyl-UMP + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1549564", "l": "PPTN11 dephosphorylates SPRY2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12403", "l": "beta-nicotinamide D-ribonucleotide + H2O <=> NH4(+) + nicotinate beta-D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109380", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75963", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432172", "l": "Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052923", "l": "all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity", "d": ["Catalysis of the reaction: geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417829", "l": "P2RY12 binds ADP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19653", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) = CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72362", "l": "glutarate(in) + succinate(out) <=> glutarate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41473", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4419986", "l": "Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60737", "l": "(2E,6E)-farnesal + H2O + NADP(+) => (2E,6E)-farnesoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351341", "l": "Exocytosis of Proactivator polypeptide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39570", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483209", "l": "PG is converted to BMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928610", "l": "PTK2 autophosphorylates at Y397 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78372", "l": "H(+) + NADH + S-nitrosoglutathione => NAD(+) + sulfinamide glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12172", "l": "alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.99.6", "l": "\"glucosamine-6-phosphate deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65724", "l": "2-oxoglutarate + O2 + pentyl sulfate = CO2 + H(+) + pentanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247935", "l": "OPLAH hydrolyses OPRO to L-Glu (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38944", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55534", "l": "2-phenylacetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-phenylalanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69297", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate => 3-hydroxypent-4-ene nitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70269", "l": "hydrogencarbonate(out) + Na(+)(out) => hydrogencarbonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78395", "l": "bilirubin IXbeta + NADP(+) = biliverdin IXbeta + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23257", "l": "adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine => adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75092", "l": "2 chloride(in) + sulfate(out) => 2 chloride(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3076905", "l": "Extracellular BTD hydrolyses BCTN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.012360833342299", "identifiers": [{"i": "GO:0016823", "l": "hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances", "d": ["Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735276", "l": "Expression of HAND1 in cardiogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35050", "l": "adenylyl-molybdopterin + H(+) + molybdate <=> AMP + H2O + Mo-molybdopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26555", "l": "angiotensin II + H2O => angiotensin-(1-7) + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61710", "l": "AMP + L-seryl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-seryl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56298", "l": "pyruvate + S-sulfanyl-L-cysteinyl-[protein] => 2-oxo-3-sulfanylpropanoate + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614787", "l": "MPZ gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16913", "l": "a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.8", "l": "\"CDP-diacylglycerol--serine O-phosphatidyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26293", "l": "(1'S,5'S)-averufin + NADPH + O2 = 1'-hydroxyversicolorone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76512", "l": "5-deoxystrigol + H2O => 5-deoxystrigol ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102351", "l": "gamma-aminobutyrate transaminase (glyoxylate dependent) activity", "d": ["Catalysis of the reaction: gamma-aminobutyric acid + 2-oxo monocarboxylic acid anion = 4-oxobutanoate + glycine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17064", "l": "H(+) + NADPH + O2 + phenol <=> catechol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70856", "l": "L-glutamine(out) + L-serine(in) + Na(+)(out) => L-glutamine(in) + L-serine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080062", "l": "cytokinin 9-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-9-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event."], "t": []}, {"i": "KEGG.REACTION:R08369", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34890", "l": "selenate(in) <=> selenate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33641", "l": "AMP + diphosphate + tetracosanoyl-CoA => ATP + CoA + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028555", "l": "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5226999", "l": "ADD1:ADD3 binds DMTN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.26", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48248", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GM1 (d18:1(4E)/18:0) = CMP + ganglioside GD1a (18:1(4E)/18:0) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70252", "l": "beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol => cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44916", "l": "(2E,4E)-decadienoyl-CoA + H(+) + NADPH = (3E)-decenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047812", "l": "D-amino-acid N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25343", "l": "H2O + urea => carbamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014343", "l": "IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110311", "l": "POLZ extends translesion synthesis (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17203", "l": "2,5-dioxopentanoate + H2O => 2-dehydro-3-deoxy-L-arabinonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57899", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77608", "l": "2 3-hexadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) => 3-hexadecanoyl-sn-glycero-1-phospho-(3'-hexadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27717", "l": "GMP + H2O <=> guanosine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78109", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + CoA => an acyl-CoA + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855179", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14711", "l": "a 3-oxo-Delta(4)-steroid => a 3-oxo-Delta(5)-steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9759154", "l": "TRIM21 ubiquitinates SQSTM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33917", "l": "H2O2 + methylamine + succinate semialdehyde => 4-(methylamino)butanoate + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33572", "l": "A + methanol => AH2 + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54673", "l": "(+)-kolavenyl diphosphate + H2O => (+)-kolavelool + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57684", "l": "4-hydroxyestrone + NH4(+) + O2 = 2 H(+) + 2 H2O + pyridinestrone carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61250", "l": "3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+) => H2O + L-tyrosine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17397", "l": "a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.100", "l": "\"3-oxoacyl-[acyl-carrier-protein] reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63619", "l": "prunetin + UDP-alpha-D-glucuronate <=> H(+) + prunetin-C(8)-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62445", "l": "L-canavanine + L-ornithine => H(+) + L-arginine + L-canaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16108", "l": "a (3S)-3-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54628", "l": "2-oxoglutarate + dodecanoyl-CoA + O2 = 2-hydroxydodecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8857555", "l": "EGFR phosphorylates GPNMB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047904", "l": "fructose 5-dehydrogenase activity", "d": ["Catalysis of the reaction: a ubiquinone + keto-D-fructose = 5-dehydro-D-fructose + a ubiquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53115", "l": "3alpha-hydroxy-5alpha-androstane 17-O-(beta-D-glucuronate) + NADP(+) <=> 5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19487", "l": "beta-D-galactosyl-(1<->1)-sphing-4-enine + H(+) + UDP => sphing-4-enine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749583", "l": "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018774", "l": "RHOBTB1 binds GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64439", "l": "glycylglycyl-L-isoleucine(out) + H(+)(out) <=> glycylglycyl-L-isoleucine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46931", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol <=> a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097020", "l": "COPII receptor activity", "d": ["Binding specifically to a substance (cargo) to deliver it to a COPII transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40813", "l": "(9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031218", "l": "arabinogalactan endo-1,4-beta-galactosidase activity", "d": ["Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010283", "l": "pinoresinol reductase activity", "d": ["Catalysis of the reaction: pinoresinol + NADPH + H+ = lariciresinol + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53971", "l": "apo-[BtrI ACP] + CoA <=> adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44642", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + ADP => a 2'-deoxyribonucleoside 5'-diphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622390", "l": "Activation of TRPC channels by Netrin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12961", "l": "acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate", "d": [], "t": []}, {"i": "EC:2.8.3.9", "l": "\"butyrate--acetoacetate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48243", "l": "a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GT1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944215", "l": "Association of procollagen type XX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68660", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) 17-sulfate + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) 17-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29892", "l": "ATP + H2O + L-histidine(out) => ADP + H(+) + L-histidine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46879", "l": "[(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate <=> [(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10381", "l": "diphosphate + orotidine 5'-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + orotate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78264", "l": "9-cis-retinol + a fatty acyl-CoA => 9-cis-retinyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852306", "l": "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656459", "l": "Defective KHK does not phosphorylate beta-D-fructose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59486", "l": "arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+) => arsenite + 2 Fe(III)-[cytochrome c] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008558", "l": "ABC-type guanine transporter activity", "d": ["Catalyses the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5444523", "l": "Formation of MSH1:PMS2 Complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199839", "l": "AKT can phosphorylate RSK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690494", "l": "RHOB translocates to the endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163489", "l": "phosphorylated HSL + H2O -> HSL + orthophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75302", "l": "NAD(+) <=> 2'cADPR + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098872", "l": "G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.5", "l": "\"ribonuclease P\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18766", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1,2-diacyl-sn-glycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070594", "l": "juvenile hormone response element binding", "d": ["Binding to a juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46809", "l": "[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine => [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168412", "l": "MDP elicits a NOD2 response (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71164", "l": "HGD dioxygenates homogentisate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13872", "l": "NAD(+) + prephenate <=> 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443817", "l": "Phosphorylation of L1 by EPHB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14124", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine <=> 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31062", "l": "H2O + imidazole-4-acetaldehyde + NAD(+) <=> 2 H(+) + imidazole-4-acetate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1801587", "l": "Expression of CPT1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2025723", "l": "B4GALTs transfer Gal to the N-glycan precursor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733292", "l": "AMY1-3 bind pramlintide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168412", "l": "MDP elicits a NOD2 response (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0032934", "l": "sterol binding", "d": ["Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668395", "l": "CHMP7 binds CC2D1B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59117", "l": "[protein]-dithiol + O2 => [protein]-disulfide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.48", "l": "\"ceramide phosphoethanolamine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35254", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O <=> ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047015", "l": "3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15068", "l": "H2O + N(4)-benzoylagmatine <=> agmatine + benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603598", "l": "BAX activation is stimulated by NTRK3(495-641) and NELFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044692", "l": "exoribonuclease activator activity", "d": ["Binds to and increases the activity of an exoribonuclease."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77067", "l": "H2O + NADP(+) + pentylamine = H(+) + NADPH + NH4(+) + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909721", "l": "Translocation of ISGF3 complex to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187368", "l": "STUB1 (CHIP) ubiquitinates SMAD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71536", "l": "D-glucose 6-phosphate(in) + phosphate(out) => D-glucose 6-phosphate(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019114", "l": "catechol dioxygenase activity", "d": ["Catalysis of the reaction: catechol + O2 = a muconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21695", "l": "CDP-glycerol + H2O <=> CMP + 2 H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55164", "l": "a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 = H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41471", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oryzalexin E + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53635", "l": "(2E,6E)-farnesyl diphosphate <=> (3S)-(+)-asterisca-2(9),6-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65425", "l": "AMP(in) + NAD(+)(out) => AMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20743", "l": "H2O + trans-2,3-epoxysuccinate <=> (2R,3S)-tartrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050531", "l": "mannosyl-3-phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948775", "l": "MKRN1 polyubiquitinates PTEN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66116", "l": "2-oxobutanoate + L-glutamine = (2S)-2-aminobutanoate + 2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1236940", "l": "Exogenous soluble antigen targeted to more stable early endosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.2.-", "l": "\"Thioether and trialkylsulfonium hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.89", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68610", "l": "Formation of ORC(2-5) complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72180", "l": "Cleavage of mRNA at the 3'-end (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18562", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432148", "l": "Fgr may phosphorylate p38 MAPK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56432", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41825", "l": "3-oxohexanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxyhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0005518", "l": "collagen binding", "d": ["Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61177", "l": "(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside => CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61047", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-(R)-19-hydroxytabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67352", "l": "malonyl-CoA + rhaponticin = 6-O-malonyl-rhaponticin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17748", "l": "N-acetyl-D-glucosamine + UDP-alpha-D-galactose <=> beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.571199156962493", "identifiers": [{"i": "GO:0061650", "l": "ubiquitin-like protein conjugating enzyme activity", "d": ["Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another molecule, usually another protein, via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9010872", "l": "SLIT2 binds Dystroglycan (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018798", "l": "RHOV binds GTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58467", "l": "a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine <=> a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9850731", "l": "Vesicles transport GSL from Golgi to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2002440", "l": "Removal of fibrillar collagen C-propeptides (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016688", "l": "L-ascorbate peroxidase activity", "d": ["Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694345", "l": "Nucleoprotein translocates to the nucleolus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67765", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64892", "l": "holo-[ACP] + tetradecanoyl-AMP = AMP + H(+) + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23396", "l": "H2O + phloretin = 1,3,5-trihydroxybenzene + H(+) + phloretate", "d": [], "t": []}, {"i": "EC:3.7.1.4", "l": "\"phloretin hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66773", "l": "ATP + H2O + uroporphyrin I(in) => ADP + H(+) + phosphate + uroporphyrin I(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052624", "l": "2-phytyl-1,4-naphthoquinone methyltransferase activity", "d": ["Catalysis of the reaction: demethylphylloquinone + S-adenosyl-L-methionine = phylloquinone + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73516", "l": "UDP(out) + UTP(in) => UDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25964", "l": "(R)-benzoin + NADP(+) = benzil + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.321", "l": "\"benzil reductase [(R)-benzoin forming]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382055", "l": "Grb7 binds to the active PDGF receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018064", "l": "protein-L-histidine N-tele-methyltransferase activity", "d": ["Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62705", "l": "glycyldehydrophenylalanine + H2O => 2,3-didehydrophenylalanine + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56176", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + A + H2O = 8-carboxy-8-demethylriboflavin 5'-phosphate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48895", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O <=> L-threonyl-[protein] + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33662", "l": "H(+) + N-tetracosanoylsphinganine + NADPH + O2 <=> H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801109", "l": "CHM binds RGGT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76972", "l": "1-(9Z-octadecenoyl)-2-(7Z,10Z,13Z,16Z,19Z-docosapentaenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O => (9Z)-octadecenoate + 2-(7Z,10Z,13Z,16Z,19Z-docosapentaenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9626816", "l": "PIN1 binds p-S345-NCF1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909718", "l": "Formation of p-STAT1 homodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21095", "l": "12-hydroxydihydrochelirubine + S-adenosyl-L-methionine <=> dihydromacarpine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1369052", "l": "ABCAs mediate lipid influx (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050106", "l": "monomethyl-sulfatase activity", "d": ["Catalysis of the reaction: H2O + monomethyl sulfate = H+ + methanol + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73902", "l": "ATP + cadaverine + L-glutamate <=> ADP + gamma-L-glutamylcadaverine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32750", "l": "ethanolamine(in) <=> ethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71567", "l": "5-phosphomethyl-dUMP in DNA + L-serine = 5-O-(L-seryl)-dTMP in DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211164", "l": "AKT phosphorylates FOXO1A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23236", "l": "[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol", "d": [], "t": []}, {"i": "EC:3.1.1.61", "l": "\"protein-glutamate methylesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77387", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35853", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35577", "l": "(1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase] => (1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48994", "l": "1,3,7-trimethyl-5-hydroxyisourate + H2O + NAD(+) => 1,3,7-trimethylurate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12943", "l": "H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP => N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36704", "l": "(2S,5S)-5-carboxymethylproline + ATP => (3S,5S)-carbapenam-3-caboxylate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202472", "l": "Translocation of TRAF6 to CBM complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55795", "l": "butan-2-one + H(+) + NADH + O2 <=> 1-hydroxy-2-butanone + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016495", "l": "C-X3-C chemokine receptor activity", "d": ["Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77916", "l": "N-hydroxyhistamine + salicylmethyloxazolinyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + pre-pseudomonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30033", "l": "cis,cis-muconate + H(+) => (S)-muconolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14202", "l": "D-lyxose => D-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3899291", "l": "SUMOylation of EP300 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34297", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP => 2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042768", "l": "ecdysteroid 2-hydroxylase activity", "d": ["Catalysis of the hydroxylation of an ecdysteroid at carbon position 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111879", "l": "PIP2 hydrolysis (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390929", "l": "HTR1 and 5A receptors can bind serotonin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53244", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] = cholesta-5,7-dien-3beta,24S-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52510", "l": "13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810937", "l": "Lamellar bodies bind the early cornified envelope (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50315", "l": "2-oxopentanoate + H(+) <=> butanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15273", "l": "2-oxoglutarate + L-dopa = 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.49", "l": "\"dihydroxyphenylalanine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102484", "l": "esculetin glucosyltransferase activity", "d": ["Catalysis of the reaction: esculetin + UDP-alpha-D-glucose(2-) = esculin + UDP(3-) + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42260", "l": "H(+) + heptanoyl-CoA + malonyl-[ACP] = 3-oxononanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55497", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-cassa-12,15-dien-2beta,3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27750", "l": "2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1236956", "l": "Engulfment of particulate antigen into phagocytic vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20676", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) <=> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050084", "l": "mannitol-1-phosphatase activity", "d": ["Catalysis of the reaction: D-mannitol 1-phosphate + H2O = D-mannitol + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201521", "l": "ALK autophosphorylation  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855185", "l": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9860273", "l": "Dimerization of p-S446-IRF5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688832", "l": "MLKL binds PDCD6IP and SDCBP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71434", "l": "3,3',5'-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) <=> 3,3',5'-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193653", "l": "NGF homodimer binds to p75NTR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78470", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GM3 + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71809", "l": "an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide => a 2'-deoxyguanosine in DNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74707", "l": "Binding of IRS to insulin receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17475", "l": "7,8-dihydroneopterin 3'-triphosphate + formate + H(+) => GTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193653", "l": "NGF homodimer binds to p75NTR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888577", "l": "Synthesis of GABA by GAD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638157", "l": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L  methylate methyl-lysine-37 of histone H3 (H3K36) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29876", "l": "H2O + sn-glycero-3-phospho-L-serine => H(+) + L-serine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451309", "l": "Edited Kainate Receptor binds glutamate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606162", "l": "Phosphorylated BTK phosphorylates PLCG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805109", "l": "CDK2 phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18997", "l": "CTP + H(+) + phosphocholine = CDP-choline + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.15", "l": "\"choline-phosphate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24409", "l": "adenosine + H(+) + H2O => inosine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66938", "l": "avenanthramide C + CoA => (E)-caffeoyl-CoA + 5-hydroxyanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30927", "l": "2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O = 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose", "d": [], "t": []}, {"i": "EC:3.2.1.172", "l": "\"unsaturated rhamnogalacturonyl hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26266", "l": "dehydroabietadienal + H2O + NADP(+) => dehydroabietate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45727", "l": "(E)-4-coumaroyl alcohol + NADP(+) <=> (E)-4-coumaraldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166726", "l": "Activation of MASPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52574", "l": "(2E)-butenoyl-CoA + H(+) + NADH => butanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693111", "l": "RHOF auto-activates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74986", "l": "Elongation of pre-rRNA transcript (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939688", "l": "SCF(SKP2) complex binds RUNX2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26392", "l": "all-trans-beta-carotene + O2 <=> all-trans-10'-apo-beta-carotenal + beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77156", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O => 1D-myo-inositol 1,4,5-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982617", "l": "CYGB:O2 dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60152", "l": "gamma-L-glutamyl-L-glutamyl-[protein] + H2O = L-glutamate + L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32467", "l": "2 S-adenosyl-L-methionine + sarcosine = glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.157", "l": "\"sarcosine/dimethylglycine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10794", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2 => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24592", "l": "CTP + H(+) + phosphoethanolamine = CDP-ethanolamine + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.14", "l": "\"ethanolamine-phosphate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37042", "l": "5 AH2 + 2 H(+) + heme b + 4 O2 <=> 5 A + delta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60122", "l": "H(+) + pre-sodorifen diphosphate + S-adenosyl-L-homocysteine => (2E,6E)-farnesyl diphosphate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46245", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 => (14E)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63908", "l": "ATP + H2O + pravastatin(in) = ADP + H(+) + phosphate + pravastatin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047223", "l": "beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835358", "l": "p-TARBP2 binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012036", "l": "ME1 tetramer decarboxylates MAL to PYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090589", "l": "protein-phosphocysteine-trehalose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044023", "l": "histone H4S1 kinase activity", "d": ["Catalysis of the reaction: histone H4-serine (position 1) + ATP = histone H4-phosphoserine (position 1) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 1 of histone H4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848776", "l": "PTK6 phosphorylates DOK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37707", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163773", "l": "Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856462", "l": "MITF-M-dependent MYO5A expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55284", "l": "all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52720", "l": "5-methyluridine(54) in tRNA + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + ATP + H2O = 5-methyl-2-thiouridine(54) in tRNA + [TtuB sulfur-carrier protein]-C-terminal Gly-Gly + AMP + diphosphate + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.8.1.15", "l": "\"tRNA-5-methyluridine(54) 2-sulfurtransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832943", "l": "POU3F1 binds the ZIC2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46521", "l": "an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68982", "l": "7-oxotaurolithocholate + H(+) + NADPH => NADP(+) + tauroursodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31107", "l": "3-phenylpyruvate + O2 = (2-hydroxyphenyl)acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200406", "l": "CPT1A,B transfers PALM to CAR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46977", "l": "(S)-6-hydroxynicotine + O2 => 6-hydroxy-N-methylmyosmine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015128", "l": "gluconate transmembrane transporter activity", "d": ["Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69005", "l": "Cdc6 protein is phosphorylated by CDK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-481010", "l": "Surface deployment of platelet dense granule membrane components (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9704330", "l": "Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9866253", "l": "apo-UQCRFS1 binds LYRM7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-180047", "l": "CDK5 phosphorylates DARPP-32 on Thr75 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28462", "l": "pyridoxal(in) = pyridoxal(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200396", "l": "Creatine transport across the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47791", "l": "a cytidine in 28S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21633", "l": "2 catechol + O2 => 2 1,2-benzoquinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204981", "l": "14-3-3epsilon attentuates NADE-related apoptosis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618004", "l": "FOXO:SMAD complex binds CDKN1A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9861631", "l": "ME1 tetramerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849891", "l": "SALMs 1-3 bind to PSD-95 family members (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26464", "l": "3-methyl-6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + H(+) + S-adenosyl-L-homocysteine => 6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45459", "l": "H2O + N-dodecanoylethanolamine <=> dodecanoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53543", "l": "(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O <=> (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448741", "l": "IL22RA2 binds IL22 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102178", "l": "4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol + O2 + NADH = 4alpha-carboxy-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102414", "l": "quercetin-3-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) = quercetin-3-gentiobioside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139920", "l": "Translocation of tBID to mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371518", "l": "SIRT1 binds to HSF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37239", "l": "2',3'-cyclophospho-UMP + H2O = H(+) + uridine 2'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61348", "l": "ATP + estrone 3-sulfate(in) + H2O = ADP + estrone 3-sulfate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912412", "l": "NOTCH1 mRNA translation controlled by miRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839053", "l": "AFG3L2:SPG7 binds SMDT1 (EMRE) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72505", "l": "glutarate(out) + prostaglandin F2alpha(in) => glutarate(in) + prostaglandin F2alpha(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614544", "l": "Sulfite is oxidized to sulfate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621425", "l": "Defective AVP mutants do not bind AVPR1A,B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74493", "l": "yaequinolone D => [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663132", "l": "p-BMAL1:p-CLOCK,NPAS2 binds DBP gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60813", "l": "2-oxoglutarate + gibberellin A12 aldehyde + O2 => CO2 + gibberellin A12 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192178", "l": "CYP39A1 7-hydroxylates 24OH-CHOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140796", "l": "histone H3R8 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H3 L-arginyl (position 8)= histone H3 L-citrullyl (position 8) + NH4+, resulting in histone H3 citrullination at position 8."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37340", "l": "3-(carbamoylamino)-2-methylpropanoate + 2 H(+) + H2O => (R)-3-amino-2-methylpropanoate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013021", "l": "GDIs block activation of RHOB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51870", "l": "demethylsuberosin + diphosphate => dimethylallyl diphosphate + umbelliferone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47372", "l": "a quinone + D-glucose = a quinol + D-glucono-1,5-lactone", "d": [], "t": []}, {"i": "EC:1.1.5.9", "l": "\"glucose 1-dehydrogenase (FAD, quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2316352", "l": "SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863471", "l": "LDLR is bound by DAB2 and ARH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621116", "l": "FOXO1,FOXO3 bind CITED2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011748", "l": "IL9R binds JAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78947", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50150", "l": "a fatty acid + ethanol + H(+) => a fatty acid ethyl ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24155", "l": "adenosine 5'-phosphosulfate + ATP <=> 3'-phosphoadenylyl sulfate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51000", "l": "[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine = [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.259", "l": "\"[fructose-bisphosphate aldolase]-lysine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109671", "l": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428690", "l": "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55204", "l": "5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.32", "l": "\"7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47759", "l": "guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74812", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61061", "l": "beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose => a neolactoside nLc4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66547", "l": "L-cysteinyl-[protein] + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5663050", "l": "DHI and DHICA polymerize forming eumelanin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0030283", "l": "testosterone dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016851", "l": "magnesium chelatase activity", "d": ["Catalysis of the reaction: ATP + H2O + Mg2+ + protoporphyrin IX = ADP + 3 H+ + Mg-protoporphyrin IX + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51495", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71598", "l": "2-oxoglutarate(out) + succinate(in) <=> 2-oxoglutarate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10821", "l": "D-threo-isocitrate => D-erythro-isocitrate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052612", "l": "adonirubin 3-hydroxylase activity", "d": ["Catalysis of the reaction: adonirubin + a reduced electron acceptor + oxygen = 3S,3'S-astaxanthin + an oxidized electron acceptor + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847968", "l": "PTEN binds FRK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559464", "l": "TLR6/2 ligand associates with CD14 and CD36 within lipid rafts (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32137", "l": "CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] => 2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16341", "l": "(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP", "d": [], "t": []}, {"i": "EC:2.7.4.2", "l": "\"phosphomevalonate kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372693", "l": "Phosphorylation of BCAR1 by SRC-PTK2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9658813", "l": "OGG1 S326C is oxidized (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71522", "l": "uridine(out) <=> uridine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11270", "l": "H(+) + hydrogen sulfide + NH4(+) + pyruvate => D-cysteine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687465", "l": "MRN complex binds RBBP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29138", "l": "a menaquinol + 2 H(+)(in) + nitrate <=> a menaquinone + 2 H(+)(out) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68561", "l": "arsenate + D-glyceraldehyde 3-phosphate + NAD(+) => 1-arsono-3-phospho-D-glycerate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19146", "l": "D-glucose 6-sulfate + H2O => D-glucose + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46109", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 => (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432036", "l": "Aquaporin-6 passively transports anions out of vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16311", "l": "chenodeoxycholate + taurine => H2O + taurochenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14697", "l": "(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.216", "l": "\"farnesol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177937", "l": "Phosphorylation of EGFR by SRC kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1067667", "l": "IL6 binds IL6R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12321", "l": "17-O-acetylnorajmaline + NADP(+) => 1,2-dihydrovomilenine + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14035", "l": "1D-myo-inositol 1-phosphate + glycerol + H(+) => H2O + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109702", "l": "PDPK1 phosphorylates AKT2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420127", "l": "CGRP receptor can bind calcitonin gene-related peptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.100", "l": "\"mannan 1,4-mannobiosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380586", "l": "loading of Serotonin in synaptic vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-912790", "l": "CBL binds CRK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874192", "l": "MBTPS2 (S2P) cleaves CREB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938815", "l": "RNF152 polyubiquitinates RRAGA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018583", "l": "biphenyl-2,3-diol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40284", "l": "(R)-carnitine + hexadecanedioyl-CoA => CoA + O-hexadecanedioyl-L-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65799", "l": "fenuron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12094", "l": "(R)-acetoin => (S)-acetoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53834", "l": "a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate => 2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68448", "l": "13-cis-lycopene + O2 = (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 13-cis-10'-apo-lycopenal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106262", "l": "1-acylglycerophosphoethanolamine O-acyltransferase activity", "d": ["Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417898", "l": "P2Y4 receptor can bind to UTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788725", "l": "Cdh1:APC/C complex binds EHMT1:EHMT2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227755", "l": "Recruitment of IKK complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69127", "l": "Formation of the Flap Intermediate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40490", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-873917", "l": "Translocation of STAT1 dimer to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33147", "l": "ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.6.2.2", "l": "\"ABC-type xenobiotic transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14304", "l": "4-pyridoxolactone + H2O <=> 4-pyridoxate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39132", "l": "3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75737", "l": "10-oxo-(11E)-octadecenoate => 10-oxo-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187261", "l": "COLEC12 (SCARA4) binds ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15865", "l": "AH2 + O2 + tryptamine = 4-hydroxytryptamine + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.59", "l": "\"tryptamine 4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46054", "l": "a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine => a 3'-end uridylyl-uridine-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9853499", "l": "DLD dimer dehydrogenates dihydrolipoyl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18304", "l": "ATP + NH4(+) + XMP <=> AMP + diphosphate + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62966", "l": "alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+) => beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5679266", "l": "Beclin-1 complex translocates to the ER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14482", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13117", "l": "O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}, {"i": "EC:2.5.1.51", "l": "\"beta-pyrazolylalanine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35712", "l": "acetate + succinyl-CoA => acetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161651", "l": "PGE2 is converted to PGF2a by CBR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692809", "l": "CDC42 binds effectors at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27886", "l": "2',3'-cyclophospho-AMP + H2O = 3'-AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5686475", "l": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163090", "l": "Elongation Of The Telomeric Chromosome End (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665989", "l": "DIAPH1 binds RHOA:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54421", "l": "3',3'-c-di-AMP + H2O => 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.12", "l": "\"glucuronate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6803890", "l": "SFN dimerizes (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193646", "l": "NGF binding to p75NTR inactivates RHOA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676149", "l": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029460", "l": "PAK1 phosphorylates LIMK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24986", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin] => (1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37205", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA => (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55386", "l": "6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1181155", "l": "The NODAL Receptor binds NODAL ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717841", "l": "holo-FDPS dimer binds NBPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4084505", "l": "Laminins bind HSPG2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225956", "l": "Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75354", "l": "2 Fe(III)-[cytochrome c] + H2O + pseudooxynicotine <=> 4-oxo-4-(pyridin-3-yl)butanal + 2 Fe(II)-[cytochrome c] + 2 H(+) + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58189", "l": "all-trans-lycopene + dimethylallyl diphosphate + H2O => dihydroisopentenyldehydrorhodopin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62292", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) = 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20531", "l": "2-cis-(+)-abscisate + H(+) + H2O2 => 2-cis-(+)-abscisic aldehyde + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202459", "l": "Phosphorylation of Bcl10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22674", "l": "diphosphate + presqualene diphosphate => 2 (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109862", "l": "MAP2K2 phosphorylates MAPK1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701507", "l": "PTPN6 dephosphorylates JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21230", "l": "beta-maltose => alpha-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59301", "l": "3'-phosphoadenylyl sulfate + firefly D-luciferin => adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170796", "l": "NPC transports GCK1:GKRP from cytosol to nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60922", "l": "a cytidine in mRNA + CO2 + formaldehyde + succinate => 2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9638120", "l": "NEU4 hydrolyses Neu5Ac from glycoconjugates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193700", "l": "p75NTR ICD signals to NF-kB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9823816", "l": "OPTN binds CASP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018754", "l": "GDIs bind RHOH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951966", "l": "EP300 acetylates RUNX3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46124", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.26", "l": "\"24-hydroxycholesterol 7alpha-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0003847", "l": "1-alkyl-2-acetylglycerophosphocholine esterase activity", "d": ["Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31565", "l": "L-glutamate + leukotriene D4 => H2O + leukotriene C4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30661", "l": "4-hydroxy-L-threonine + phosphate => 4-(phosphooxy)-L-threonine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21114", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose => a globoside Gb3Cer (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9859163", "l": "DBT transfers BCAA to CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47246", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+) => (2R)-3-phosphoglycerate + an NDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30060", "l": "(S)-dihydroorotate + fumarate => orotate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801808", "l": "REG3A,REG3G binds bacterial peptidoglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0005006", "l": "epidermal growth factor receptor activity", "d": ["Combining with an epidermal growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696323", "l": "CNRs bind CNR agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50848", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67663", "l": "an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139895", "l": "tBID activates BAK protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45724", "l": "(E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15819", "l": "H2O2 + NH4(+) + pyridoxal 5'-phosphate => H2O + O2 + pyridoxamine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9856871", "l": "MDH1 reduces OA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41975", "l": "a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GT1aalpha (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404134", "l": "RBP4:atROL binds TTR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52561", "l": "2-dehydro-D-erythronate => 3-dehydro-D-erythronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60681", "l": "(+)-artemisinic aldehyde + H2O + NADP(+) => (+)-artemisinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2529020", "l": "CK2 phosphorylates condensin I subunits (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43330", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39721", "l": "24-hydroxytetracosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33801", "l": "H(+) + L-histidinal + NADH => L-histidinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706977", "l": "6:KPNA2 binds KPNB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013108", "l": "GDIs block activation of RHOC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47426", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA => (2E,9Z)-octadecadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066299", "l": "DVL2 binds phosphorylated WWTR1 (TAZ) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45103", "l": "6-demethylmitomycin B + S-adenosyl-L-methionine <=> mitomycin B + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050096", "l": "methylaspartate ammonia-lyase activity", "d": ["Catalysis of the reaction: threo-3-methyl-L-aspartate = mesaconate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446372", "l": "Association of  PARVA with TESK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20954", "l": "beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77870", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-leucine + O2 <=> 2-dehydro-D-glucose + H2O2 + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67349", "l": "apigenin 7-O-beta-D-glucoside + malonyl-CoA => apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046523", "l": "S-methyl-5-thioribose-1-phosphate isomerase activity", "d": ["Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22268", "l": "ATP + streptomycin = ADP + H(+) + streptomycin 6-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.72", "l": "\"streptomycin 6-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69591", "l": "inosine + UMP <=> IMP + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58704", "l": "rifampicin hemiaminal = rifampicin ortho-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653886", "l": "B4GALT1 binds LALBA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761166", "l": "Expression of LHX1 in intermediate mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626549", "l": "IQGAPs bind CALM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55765", "l": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O => 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72725", "l": "UDP-alpha-D-xylose(out) + UMP(in) => UDP-alpha-D-xylose(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65853", "l": "a 3-oxo-Delta(1)-steroid + H2O => a 1-hydroxy-3-oxo steroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030783", "l": "[cytochrome c]-methionine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936851", "l": "AHRR binds ARNT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050087", "l": "mannitol dehydrogenase (cytochrome) activity", "d": ["Catalysis of the reaction: 2 [Fe(III)cytochrome c] + D-mannitol = 2 [Fe(II)cytochrome c] + D-fructose + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0016530", "l": "metallochaperone activity", "d": ["Binding to and delivering metal ions to a target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27701", "l": "GDP-beta-L-galactose + phosphate <=> beta-L-galactose 1-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050279", "l": "sepiapterin deaminase activity", "d": ["Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77408", "l": "2,2-dimethylpropanal + hydrogen cyanide => (2S)-2-hydroxy-3,3-dimethylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35410", "l": "H2O + medicarpin <=> 4'-methoxyisoflavan-2',4,7-triol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23427", "l": "alpha-D-glucosamine 1-phosphate <=> D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789160", "l": "Hydrogen peroxide and Fe2+ react to hydroxyl, hydroxide and Fe3+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32767", "l": "cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48228", "l": "a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": [], "t": []}, {"i": "EC:2.3.1.269", "l": "\"apolipoprotein N-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047634", "l": "agmatine N4-coumaroyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = N-(4-guanidiniumylbutyl)-4-hydroxycinnamamide + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008467", "l": "[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74137", "l": "petunidin 3-O-beta-D-galactoside + UDP => petunidin + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32103", "l": "2 S-adenosyl-L-methionine + trans-resveratrol = 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.240", "l": "\"trans-resveratrol di-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0061599", "l": "molybdopterin molybdotransferase activity", "d": ["Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5669013", "l": "EDA-3 binds EDA2R (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70971", "l": "ACO2 isomerizes citrate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65544", "l": "a ganglioside GM1 + H2O = an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350396", "l": "DSH binds to DAAM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9680443", "l": "ROCK1,2 bind ROCKi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62043", "l": "H2O + N-(octanoyl)-sphing-4-enine-1-phosphate <=> N-octanoylsphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30728", "l": "dATP + pyruvate => dADP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54776", "l": "1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine = [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54561", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-tRNA(His) + GTP => a 5'-end triphospho-guanosine-ribonucleotide-tRNA(His) + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.18", "l": "\"inulin fructotransferase (DFA-III-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73961", "l": "4-ethyl-2-methoxyphenol + NAD(+) => 2-methoxy-4-vinylphenol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53696", "l": "2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69757", "l": "(E)-2-aminocinnamoyl-CoA + CO2 + H2O2 => (2-aminobenzyl)malonyl-CoA + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61877", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => 1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12012", "l": "ATP + thiamine = ADP + H(+) + thiamine phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.89", "l": "\"thiamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17488", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963589", "l": "ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63914", "l": "6-azauridine 5'-phosphate + ADP + H(+) => 6-azauridine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39552", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H(+) + NADPH => (21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038006", "l": "netrin receptor activity involved in chemoattraction", "d": ["Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell towards a higher concentration of netrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696600", "l": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76737", "l": "3-decanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => decane + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35211", "l": "dIDP + H2O = dIMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42416", "l": "a ubiquinone + L-proline = (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48565", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O => D-ribose 5-phosphate + trans-zeatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30454", "l": "(S)-2,3-epoxysqualene <=> isomultiflorenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10599", "l": "ATP + L-tyrosyl-[protein] <=> ADP + H(+) + O-phospho-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-976768", "l": "Factor H binds to C3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707645", "l": "HMOX1 gene produces HMOX1 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9842115", "l": "PSAP(195-273) dimer binds PE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018794", "l": "RHOV binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106365", "l": "beta-carotene isomerase activity", "d": ["Catalyzes the reaction: all-trans-beta-carotene = 9-cis-beta-carotene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10173", "l": "(3R)-hydroxybutanoate dimer + H2O => 2 (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26268", "l": "dehydroabietadienal + H2O + NADP(+) <=> dehydroabietate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51734", "l": "H(+) + meleagrin + S-adenosyl-L-homocysteine => glandicoline B + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45281", "l": "12-(phosphooxy)octadecanoate + H2O => 12-hydroxyoctadecanoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749609", "l": "BCHE hydrolyzes ASA- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53463", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47068", "l": "4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045030", "l": "G protein-coupled UTP receptor activity", "d": ["Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60652", "l": "an N-(acyl)-sphingosylphosphocholine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24027", "l": "(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate <=> (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68348", "l": "ATP + GTP = diphosphate + pppA(2'-5')pG", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42545", "l": "uridine(32) in tRNA => pseudouridine(32) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-879222", "l": "MDP:NLRP1 binds ATP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-376122", "l": "DSCAM/DSCAML1 homodimerization (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.94", "l": "\"glucan 1,6-alpha-isomaltosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849085", "l": "ARHGAP35 binds RHOA:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43803", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine <=> 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32668", "l": "coenzyme M + methanethiol => H(+) + hydrogen sulfide + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17536", "l": "2-oxoglutarate + an aromatic L-alpha-amino acid <=> an aromatic oxo-acid + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.158", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033926", "l": "endo-alpha-N-acetylgalactosaminidase activity", "d": ["Catalysis of the reactions : D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine and D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-threonyl + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-threonyl."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59221", "l": "(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O => (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3899291", "l": "SUMOylation of EP300 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41103", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41662", "l": "NADH + sanguinarine => dihydrosanguinarine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.4.2.1", "l": "\"ABC-type polar-amino-acid transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781905", "l": "ZRANB1 binds APC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905334", "l": "Swi5-Sfr1 complex binding", "d": ["Binding to a Swi5-Sfr1 complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42247", "l": "H(+) + malonyl-[ACP] + propanoyl-CoA <=> 3-oxopentanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102258", "l": "1,3-diacylglycerol acylhydrolase activity", "d": ["Catalysis of the reaction: H2O + a 1,3-diglyceride = a monoglyceride + a fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46651", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA <=> androst-4-ene-3,17-dione + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008835", "l": "diaminohydroxyphosphoribosylaminopyrimidine deaminase activity", "d": ["Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O + H+ = 5-amino-6-(5-phosphoribosylamino)uracil + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55077", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) => 3-methylsulfanylpropanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57359", "l": "2-oxoglutarate + chloride + H(+) + hapalindole U + O2 <=> CO2 + H2O + hapalindole G + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66794", "l": "(3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2 => N-methyl-D-dopa + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75869", "l": "5-methyl-5,6,7,8-tetrahydromethanopterin + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => 5,6,7,8-tetrahydromethanopterin + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60675", "l": "NAD(+) + nerol <=> H(+) + NADH + neral", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666426", "l": "CRKII:DOCK180:ELMO binds FCGR3A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029454", "l": "Autophosphorylation of PAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11439", "l": "4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 <=> 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67400", "l": "(2E,6E)-farnesyl diphosphate = allo-aromadendrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56091", "l": "a globoside MSGG + CMP-N-acetyl-beta-neuraminate <=> a globoside DSGG + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.21", "l": "\"thymidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29063", "l": "a menaquinone + formate + H(+) = a menaquinol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61681", "l": "ATP + holo-[peptidyl-carrier protein] + L-cysteine => AMP + diphosphate + L-cysteinyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31739", "l": "a 4'-hydroxyisoflavone + S-adenosyl-L-methionine = a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.46", "l": "\"isoflavone 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109857", "l": "MAP2K1 binds MAPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65232", "l": "3-hydroxydodecanoyl-CoA + H2O = 3-hydroxydodecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13139", "l": "cyclolaudenol + H(+) + S-adenosyl-L-homocysteine => cycloartenol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46348", "l": "(2E)-octenoyl-CoA + H2O = 3-hydroxyoctanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008068", "l": "extracellularly glutamate-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730886", "l": "Phosphorylation of SHC by SYK kinase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9646685", "l": "Aggresome dissociates from dynein and microtubule (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55770", "l": "all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP => all-trans-retinoate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-164840", "l": "ADP and Pi bind to ATPase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938121", "l": "SERPINB13 binds CTSK (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20269", "l": "4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate", "d": [], "t": []}, {"i": "EC:4.2.2.6", "l": "\"oligogalacturonide lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49762", "l": "ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O => EDTA + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103079", "l": "2-(3'-methylthio)propylmalate synthase activity", "d": ["Catalysis of the reaction: 5-methylthio-2-oxopentanoate + acetyl-CoA + H2O = H+ + 2-(3-methylthiopropyl)malate + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047772", "l": "carboxymethyloxysuccinate lyase activity", "d": ["Catalysis of the reaction: carboxymethoxysuccinate = fumarate + glycolate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74369", "l": "substance P(in) => substance P(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696357", "l": "LAIR2 binds collagen (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43174", "l": "N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine => guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78179", "l": "a 1,3-diacylglycerol + an acyl-CoA = a triacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30200", "l": "2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate => 2 ATP + benzoyl-CoA + 2 H2O + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39855", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol = a triacyl-sn-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.3.18", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25026", "l": "H(+) + H2O + S-methyl-5'-thioadenosine => NH4(+) + S-methyl-5'-thioinosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59992", "l": "H(+) + oxidized [electron-transfer flavoprotein] + phloretate = (E)-4-coumarate + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879377", "l": "The TRTK-12 fragment of F-actin capping protein alpha binds the AGER ligand S100B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68090", "l": "a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase] => a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009488", "l": "IL34 binds CSF1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196964", "l": "RFK:Mg2+ phosphorylates RIB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50841", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57374", "l": "(6S)-NADPHX => H2O + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5626938", "l": "Beta-catenin binds SOX proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11151", "l": "4 Fe(2+) + 4 H(+) + O2 <=> 4 Fe(3+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617652", "l": "HOXD3 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59714", "l": "D-maltotetraonate + H(+) => D-maltotetraono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30551", "l": "acetyl-CoA + beta-D-glucose = 6-O-acetyl-beta-D-glucose + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1566979", "l": "Laminin-332 degradation by laminin-322 degrading extracellular proteinases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839371", "l": "TGFBR3 transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31439", "l": "(2E,6E)-farnesyl diphosphate = alpha-longipinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.80", "l": "\"alpha-longipinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29996", "l": "ATP + H2O + putrescine(out) => ADP + H(+) + phosphate + putrescine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72586", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA + NAD(+) <=> 3,22-dioxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34210", "l": "3-O-alpha-D-glucosyl-L-rhamnose + phosphate <=> beta-D-glucose 1-phosphate + L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49091", "l": "FAD + H(+) + H2O + squalene <=> FADH2 + hydroxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69005", "l": "Cdc6 protein is phosphorylated by CDK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.3", "l": "\"pyroglutamyl-peptidase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180632", "l": "Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617825", "l": "TRAF3IB1 recruits IFT20 to the IFT B complex from the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844366", "l": "EBF2 binds target gene loci (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27690", "l": "ATP + dGDP = ADP + dGTP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74390", "l": "formamide(out) <=> formamide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420117", "l": "VEGFR2 autophosphorylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.4", "l": "\"peptidyl-dipeptidase B\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27554", "l": "(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate <=> di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61552", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17998", "l": "Co-precorrin-2 + S-adenosyl-L-methionine => Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13219", "l": "2 H(+) + NADH + succinate => H2O + NAD(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52257", "l": "a 7(1)-hydroxybacteriochlorophyllide c + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964599", "l": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62056", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28722", "l": "adenine(in) + H(+)(in) <=> adenine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68198", "l": "1,2-dihexanoyl-3-tetradecanoylglycerol + CoA => 1,2-dihexanoylglycerol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61540", "l": "ent-kaur-16-en-19-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696275", "l": "RND2 binds GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40290", "l": "ATP + CoA + decanedioate <=> AMP + decanedioyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63404", "l": "3,6-dichloropyridine-2,5-diol + FADH2 + O2 = 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66997", "l": "2-methylpentanoate + ATP + CoA => 2-methylpentanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44409", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67192", "l": "ATP + H2O + N-11-cis-retinylidenephosphatidylethanolamine(out) = ADP + H(+) + N-11-cis-retinylidenephosphatidylethanolamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54004", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55376", "l": "2 a quinol + O2 = 2 a quinone + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50444", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 = prostaglandin G3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48128", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73879", "l": "histamine(out) = histamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9860278", "l": "p-S446-IRF5 dimer translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023351", "l": "DLL1 gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70713", "l": "D-alanine(out) => D-alanine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57236", "l": "GMP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56875", "l": "(S)-N-acetyl-1-phenylethylamine + H2O <=> (S)-1-phenylethylamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225952", "l": "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024630", "l": "Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67435", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53992", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65337", "l": "chrodrimanin T + H(+) + NADPH + O2 => chrodrimanin A + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981610", "l": "Neuroglobin binds oxygen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56510", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H(+) + UDP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77077", "l": "Capping complex formation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78194", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine <=> a 2-acyl-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0110068", "l": "glucosylglycerate phosphorylase activity", "d": ["Catalysis of the reaction: glucosylglycerate + phosphate = glucose-1-phosphate + D-glycerate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21089", "l": "2-oxoglutarate + a (2R,3R)-dihydroflavonol + O2 => a flavonol + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53906", "l": "ADP + H(+) + O-phospho-L-threonyl-[tau protein] => ATP + L-threonyl-[tau protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388830", "l": "PI3K binds ICOS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10257", "l": "[(1->4)-6-phospho-alpha-D-glucosyl](n) + n ATP + n H2O => [(1->4)-3,6-bisphospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19331", "l": "H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP => nuatigenin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51504", "l": "a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose = a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.360", "l": "\"2-hydroxyflavanone C-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174104", "l": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20474", "l": "(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] => AMP + 2 H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875451", "l": "MET phosphorylates CBL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42936", "l": "S-adenosyl-L-methionine + uridine(32) in tRNA = 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54186", "l": "a carboxylate + an aromatic L-alpha-amino acid => an N-acyl-aromatic L-alpha-amino acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694522", "l": "Inner coat assembly and cargo binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29016", "l": "phosphate(out) + sn-glycerol 3-phosphate(in) => phosphate(in) + sn-glycerol 3-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696564", "l": "USP25 deubiquitinates DDX58 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38895", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59080", "l": "bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose = 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951644", "l": "Release of mature NEDD8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74802", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18559", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA => 1-O-alkyl-sn-glycero-3-phosphate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112436", "l": "Formation of Elongin complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41416", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14130", "l": "cholate + NADP(+) => 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4546386", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24393", "l": "dTDP-L-dihydrostreptose + streptidine 6-phosphate => dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254291", "l": "ERBB4s80 binds STAT5A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-450095", "l": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102779", "l": "cannabidiolate synthase activity", "d": ["Catalysis of the reaction: cannabigerolate + O2 = cannabidiolate + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37901", "l": "7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate => 2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14587", "l": "CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156682", "l": "PLK1 phosphorylates NUDC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26245", "l": "geranylgeranyl diphosphate = diphosphate + fusicocca-2,10(14)-diene", "d": [], "t": []}, {"i": "EC:4.2.3.43", "l": "\"fusicocca-2,10(14)-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19439", "l": "N-(beta-D-glucosyl)nicotinate + UDP => nicotinate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952996", "l": "E2F7 forms homodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74258", "l": "XDH oxidizes xanthine to form urate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40550", "l": "10-deoxymethymycin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + novamethymycin + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755478", "l": "TOPORS SUMOylates IKBKE with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803914", "l": "TP53 binds the RGCC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31882", "l": "(S)-2,3-epoxysqualene <=> beta-seco-amyrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33660", "l": "H(+) + N-tetracosanoylsphinganine + NADPH + O2 => H2O + N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45423", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27437", "l": "2 glutathione amide + H2O2 = glutathione amide disulfide + 2 H2O", "d": [], "t": []}, {"i": "EC:1.11.1.17", "l": "\"glutathione amide-dependent peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169405", "l": "ISGylation of protein phosphatase 1 beta (PP2CB) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928577", "l": "ROCK phosphorylates LIMK1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45421", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine => a fatty acid + H(+) + N-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59493", "l": "(2E)-geranyl diphosphate + L-tryptophyl-[protein] => (2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72759", "l": "anthocyanin A6 + malonyl-CoA = anthocyanin A8 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879594", "l": "SLCO4C1 mediates the transport of digoxin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047128", "l": "1,2-dehydroreticulinium reductase (NADPH) activity", "d": ["Catalysis of the reaction: (R)-reticuline + NADP+ = 1,2-dehydroreticuline + H+ + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71694", "l": "glycyl-L-glutamate(out) + 2 H(+)(out) <=> glycyl-L-glutamate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33828", "l": "ergosterol => vitamin D2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050178", "l": "phenylpyruvate tautomerase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32000", "l": "(2E,6E)-farnesyl diphosphate => bicyclogermacrene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73463", "l": "carcinine + H2O = beta-alanine + histamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141202", "l": "MAOB:FAD oxidatively deaminates TYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229152", "l": "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41188", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69647", "l": "H2O + quercetin 4'-O-beta-D-glucoside = beta-D-glucose + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0097266", "l": "phenylacetyl-CoA 1,2-epoxidase activity", "d": ["Catalysis of the reaction: phenylacetyl-CoA + H+ + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18775", "l": "Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034322", "l": "alcohol O-decanoyltransferase activity", "d": ["Catalysis of the reaction: decanoyl-CoA + an alcohol = CoA + a decyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41208", "l": "1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O => 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016161", "l": "beta-amylase activity", "d": ["Catalysis of the reaction: (1,4-alpha-D-glucosyl)(n+1) + H2O = (1,4-alpha-D-glucosyl)(n-1) + alpha-maltose. This reaction is the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112708", "l": "PTPN11 binds p-Y759-IL6ST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31470", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose <=> bis(beta-D-glucosyl) crocetin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2248891", "l": "M6PR transports activated ARSA to the lysosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254291", "l": "ERBB4s80 binds STAT5A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49360", "l": "2',2'-dihydroxy-2-oxospirilloxanthin = 2,2'-dioxospirilloxanthin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109700", "l": "AKT2 binds PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.83", "l": "\"oligopeptidase B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517705", "l": "p-S318,221-HuR binds mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9034539", "l": "PXLP-K56-SRR dimer deaminates L-Ser (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840408", "l": "OMA1 cleaves DELE1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.11", "l": "\"2-haloacid dehalogenase (configuration-retaining)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16678", "l": "fluoroacetaldehyde + H2O + NAD(+) => fluoroacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854466", "l": "VLDLR binds RELN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53808", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76280", "l": "hypoxanthine(out) + Na(+)(out) => hypoxanthine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33319", "l": "a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46893", "l": "2-oxoglutarate + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate => 3,8-dideoxy-8-oxo-alpha-D-manno-octulosonate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672304", "l": "IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18741", "l": "10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.166", "l": "\"2alpha-hydroxytaxane 2-O-benzoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69681", "l": "apigenin + beta-D-glucose => apigenin 7-O-beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38304", "l": "2-amino-2-deoxy-D-gluconate 6-phosphate => 2-dehydro-3-deoxy-6-phospho-D-gluconate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21572", "l": "3-hydroxy-2-methyl-1H-quinolin-4-one + O2 = CO + H(+) + N-acetylanthranilate", "d": [], "t": []}, {"i": "EC:1.13.11.48", "l": "\"3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37066", "l": "2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine <=> 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102266", "l": "tRNA-dihydrouridine20a synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil20a in tRNA + NAD(P) = H+ + a uracil20a in tRNA + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:1905058", "l": "calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15558", "l": "ATP + H2O + Ni(2+)(out) => ADP + H(+) + Ni(2+)(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18011", "l": "CoA + H(+) + N(6)-glutaryl-L-lysyl-[protein] => glutaryl-CoA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109700", "l": "AKT2 binds PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33986", "l": "(+)-copalyl diphosphate <=> diphosphate + miltiradiene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73215", "l": "sulfate(out) + thiosulfate(in) = sulfate(in) + thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019976", "l": "interleukin-2 binding", "d": ["Binding to interleukin-2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21093", "l": "12-hydroxydihydrochelirubine + S-adenosyl-L-methionine => dihydromacarpine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10980", "l": "L-serine = D-serine", "d": [], "t": []}, {"i": "EC:5.1.1.18", "l": "\"serine racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30097", "l": "a menaquinol + oxaloacetate => (S)-malate + a menaquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30833", "l": "UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose => UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.16", "l": "\"HIV-1 retropepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749452", "l": "The Ligand:GPCR:Gq complex dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53743", "l": "[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O <=> [Rab1 protein]-L-tyrosine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37463", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + sn-glycerol 3-phosphate = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19817", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75361", "l": "2-aminoprop-2-enoate + 3-hydroxy-4H-pyrid-4-one => L-mimosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67095", "l": "ATP + docosanoate(in) + H2O <=> ADP + docosanoate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62026", "l": "campesterol + D-glucose => campesteryl 3-beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983518", "l": "IL35 binds IL6ST:IL6ST receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389756", "l": "AKT interacts and phosphorylates Cot (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29580", "l": "Fe(2+)(in) + H(+)(in) => Fe(2+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847977", "l": "FRK phosphorylates PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44342", "l": "AMP + diphosphate + N(3)-fumaroyl-(S)-2,3-diaminopropanoate => (S)-2,3-diaminopropanoate + ATP + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508282", "l": "SYK is a substrate for JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31722", "l": "11alpha-hydroxy-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] <=> 11-oxo-beta-amyrin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70532", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42918", "l": "2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine => adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5603467", "l": "Activated protein C is released from PROCR (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32832", "l": "an R-cob(III)alamin(in) => an R-cob(III)alamin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17573", "l": "demethylmacrocin + S-adenosyl-L-methionine = H(+) + macrocin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.102", "l": "\"demethylmacrocin O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21459", "l": "(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44280", "l": "2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA = 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5252072", "l": "AZGP1 binds PIP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37346", "l": "adenosine 2'-phosphate + H2O <=> adenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62822", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O => 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9856510", "l": "STARD7 transports Q10 to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70258", "l": "1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56010", "l": "4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) => 4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62738", "l": "1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate => 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69049", "l": "H2O + hexano-6-lactone => 6-hydroxyhexanoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28336", "l": "dAMP + diphosphate + H(+) => dATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975594", "l": "PLB1 hydrolyses RPALM to atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174235", "l": "Association of Emi1 with Cdc20 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61341", "l": "(S)-methylmalonyl-CoA + H(+) => CO2 + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66859", "l": "(2E)-geranyl diphosphate + 3 isopentenyl diphosphate <=> (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62628", "l": "a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.11.1.26", "l": "\"NADH-dependent peroxiredoxin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198813", "l": "GSTO dimers reduce DeHA to AscH- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-936642", "l": "deacetylation of O-acetylserine and sulfhydrylation using CysK1 (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71554", "l": "5-N(alpha)-glycyl-dTMP in DNA + AH2 + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 5-C(alpha)-glycyl-dTMP in DNA + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73522", "l": "dUTP(out) + UTP(in) <=> dUTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78039", "l": "1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-3-acylglycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4608855", "l": "PRICKLE1 is degraded by the proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40591", "l": "decanedioyl-CoA + H2O = CoA + decanedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421201", "l": "inosine 5'-monophosphate (IMP) + L-aspartate + GTP => adenylosuccinate + GDP + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71215", "l": "2 Na(+)(out) + thiocyanate(out) = 2 Na(+)(in) + thiocyanate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042881", "l": "D-galactonate transmembrane transporter activity", "d": ["Enables the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0031846", "l": "neurotensin receptor binding", "d": ["Binding to a neurotensin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29128", "l": "a menaquinol + nitrate => a menaquinone + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57059", "l": "D-apiofuranose + NAD(+) <=> D-apionolactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9857585", "l": "MITF-M-dependent DIAPH1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018624", "l": "toluene dioxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54782", "l": "[LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide => [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191656", "l": "Closure of gap junction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73350", "l": "beta-alanyl-[peptidyl-carrier protein] + tryptamine <=> beta-alanyl-tryptamine + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66212", "l": "asc-omegaC5-CoA + O2 = asc-omegaDeltaC5-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912627", "l": "CBL ubiquitinates PI3K (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54217", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 => 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3857336", "l": "CEBPB homodimerization (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78665", "l": "H2O + NADP(+) + penifulvin A => gamma-lactone-2-keto[5.5.5.5]fenestrane + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36133", "l": "methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine => (indol-3-yl)acetate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58716", "l": "FADH2-C4alpha-hydroperoxide + NADH + rifampicin = FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31619", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = dTDP-3-dehydro-6-deoxy-alpha-D-galactose + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.90", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-622415", "l": "RIP2 binds NEMO (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16649", "l": "(S)-N-methylcoclaurine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-3'-hydroxy-N-methylcoclaurine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.102", "l": "\"N-methylcoclaurine 3'-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40266", "l": "(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) <=> 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64741", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine => 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66777", "l": "ATP + H2O + uroporphyrin III(in) => ADP + H(+) + phosphate + uroporphyrin III(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901036", "l": "MAN1B1 hydrolyses a second 1,2-linked mannose (a branch) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15149", "l": "O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52478", "l": "estrone 3-O-(beta-D-glucuronate) + H(+) + UDP => estrone + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5333678", "l": "CPNEs bind PL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928627", "l": "EPHB phosphorylates TIAM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51430", "l": "2-N-acetamidomethylphosphonate + CoA => acetyl-CoA + aminomethylphosphonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23597", "l": "H2O + 2 NAD(+) + UDP-alpha-D-glucose => 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22963", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] <=> calycosin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11405", "l": "UDP-alpha-D-glucuronate => UDP-alpha-D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59031", "l": "(Z)-24-ethylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43879", "l": "3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oate + ATP + CoA <=> 3-hydroxy-9-oxo-9,10-seco-chola-1,3,5-trien-22-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687435", "l": "Enhanced autophagosome formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61202", "l": "CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside] => acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9853385", "l": "PPP1CC dephosphorylates PLK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52421", "l": "O-phospho-L-serine + thiosulfate => phosphate + S-sulfo-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430135", "l": "p-SLP-76 binds ADAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008908", "l": "isochorismatase activity", "d": ["Catalysis of the reaction: H2O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432164", "l": "Ca2+ influx into the post-synaptic cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29230", "l": "H(+)(in) + indole(in) <=> H(+)(out) + indole(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30145", "l": "CoA + H(+) + octanoate => H2O + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874849", "l": "CREBRF binds CREB3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33673", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2 => an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-140783", "l": "tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15218", "l": "ecdysone + hexadecanoyl-CoA => CoA + ecdysone hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74599", "l": "AMP(out) + UDP-alpha-D-galactose(in) = AMP(in) + UDP-alpha-D-galactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050065", "l": "lysine-pyruvate 6-transaminase activity", "d": ["Catalysis of the reaction: L-lysine + pyruvate = L-alanine + L-allysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32657", "l": "a coniferyl ester + NADPH => a carboxylate + eugenol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729704", "l": "SARS-CoV-2 3CLpro dimer cleaves TAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444433", "l": "Cho transports from the extracellular space to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-380930", "l": "Phosphorylated AMPK binds AMP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047749", "l": "cholestanetriol 26-monooxygenase activity", "d": ["Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1549526", "l": "Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050217", "l": "propioin synthase activity", "d": ["Catalysis of the reaction: 4-hydroxyhexan-3-one = 2 propanal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31056", "l": "estrone 3-sulfate + H2O => estrone + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70899", "l": "histidine => urocanate + NH4+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64168", "l": "2-ethyl-L-serine = (2S)-2-aminobutanoate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32365", "l": "H(+) + H2O2 + L-ascorbate => L-gulono-1,4-lactone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15268", "l": "1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate <=> H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110219", "l": "Cleavage of thymine by TDG glycosylase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74912", "l": "a (2E)-enoyl fatty acid + ATP + holo-[ACP] => a (2E)-enoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44122", "l": "CoA + octadecanyl hexadecanoate => hexadecanoyl-CoA + octadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832040", "l": "M2-1 localizes to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32592", "l": "(4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O => (3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63292", "l": "N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850818", "l": "SPINK9 binds KLK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20403", "l": "a substituted beta-amino acid => a beta-lactam + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45519", "l": "phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.12.-", "l": "\"Exodeoxyribonucleases producing 3'-phosphomonoesters\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55188", "l": "5-methyluridine(54) in tRNA + ATP + hydrogen sulfide = 5-methyl-2-thiouridine(54) in tRNA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19478", "l": "4-hydroxybenzoate + H(+) + NADPH + O2 => 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9700171", "l": "Active ALK phosphorylates PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.41", "l": "\"sterol 22-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21083", "l": "ATP + H2O + L-methionine <=> diphosphate + phosphate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77691", "l": "a ganglioside GD1b (d18:1(4E)) + GDP-beta-L-fucose = a ganglioside Fuc-GD1b (d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17885", "l": "acetaldehyde = acetylene + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.112", "l": "\"acetylene hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36796", "l": "a ribonucleoside 5'-triphosphate + 2 H2O => a ribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30697", "l": "beta-alanine + 2 H(+) + NADH => 3-aminopropanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21039", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036401", "l": "pyrokinin receptor activity", "d": ["Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53225", "l": "16alpha,17alpha-dihydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,16alpha-dihydroxy-androst-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050127", "l": "N-carbamoylsarcosine amidase activity", "d": ["Catalysis of the reaction: N-carbamoylsarcosine + H2O + 2 H+ = CO2 + NH4 + sarcosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69662", "l": "H2O + kaempferol 3-O-beta-D-glucoside <=> beta-D-glucose + kaempferol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690740", "l": "CD22 binds B-cell receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73274", "l": "rhamnetin + S-adenosyl-L-methionine <=> H(+) + rhamnacene + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314566", "l": "GORASP1 phosphorylated by PLK1 and GORASP2 phosphorylated by MAPK3-3/MAPK1 are unable to promote Golgi cisternae stacking (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40540", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + methymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23997", "l": "a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36340", "l": "[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28800", "l": "H2O + L-prolinylglycine => glycine + L-proline", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66139", "l": "acetyl-CoA + tyramine <=> CoA + H(+) + N-acetyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8856951", "l": "PP2A demethylation by PPME1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39923", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203979", "l": "Coat Assembly (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9736836", "l": "Phosphorylated YBX1 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57523", "l": "15,16-epoxydolabrene + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxy-15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77816", "l": "(2S)-3-methyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]butanoate + H(+) + H2O => 2-dehydro-D-glucose + L-valine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60090", "l": "a 4alpha-methyl-3-oxosteroid + CO2 + NADPH => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37905", "l": "H(+) + S-adenosyl-L-homocysteine + tryprostatin A => 6-hydroxytryprostatin B + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5675790", "l": "MTORC1 dissociates from ULK complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420206", "l": "Phosphorylation of SRC-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624133", "l": "ARL3:GTP binds the UNC119B complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33365", "l": "D-mannitol 1-phosphate(in) + L-histidyl-[protein] => D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28373", "l": "oxaloacetate + phosphate <=> hydrogencarbonate + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210769", "l": "HNF6- and FGF10-dependent synthesis of PDX1 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44303", "l": "2 H(+) + malonyl-CoA + methylmalonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-5-methyl-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786101", "l": "IL4 binds IL4R:JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4549368", "l": "Defective ALG2 does not transfer a second Man to N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51399", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + serotonin <=> CoA + H(+) + N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9010815", "l": "SLITs bind keratan sulfate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48579", "l": "4-chlorocatechol + O2 <=> 3-chloro-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21522", "l": "CO2 + 2 Fe(II)-[cytochrome b1] + H(+) => 2 Fe(III)-[cytochrome b1] + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482745", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619430", "l": "PPM1E dephosphorylates CAMK4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60761", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone => CoA + jasmolin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002466", "l": "Formation of allysine by LOX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36952", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2 => (9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58186", "l": "(14E,18E)-lycopadiene + 2 diphosphate + NADP(+) => H(+) + NADPH + 2 phytyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9854405", "l": "Frataxin transfers Fe2+ to ACO2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36105", "l": "O-methyl anthranilate + S-adenosyl-L-homocysteine => anthranilate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10301", "l": "D-glyceraldehyde 3-phosphate + NAD(+) + phosphate => (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13898", "l": "chorismate => prephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450348", "l": "Activated human JNKs migrate to nucleoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57216", "l": "dGTP + glyoxal = N(2)-(1-hydroxy-2-oxoethyl)-dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74807", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707505", "l": "Hemes bind to CLEC1B dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-921155", "l": "p-STAT5 dissociates from the receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5246693", "l": "APC is K63-polyubiquitinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2574840", "l": "AJUBA facilitates AURKA autophosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24748", "l": "2-aminobut-2-enoate + methanethiol => L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63074", "l": "4 CO2 + 4 CoA + orcinol => acetyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10267", "l": "alpha-D-glucose <=> beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990226", "l": "histone methyltransferase binding", "d": ["Binding to a histone methyltransferase enzyme."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009541", "l": "ESR1 binds to TFF1 gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57129", "l": "H2O + 2 oxidized [azurin] + tyramine => (4-hydroxyphenyl)acetaldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40487", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45170", "l": "2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine => 2 (E)-sinapoyl-CoA + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72311", "l": "glutathione(in) + taurocholate(out) = glutathione(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67641", "l": "ATP + dZMP => ADP + dZDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75263", "l": "isovitexin + O2 = 3''-dehydroisovitexin + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45268", "l": "4'-hydroxyechinenone + AH2 + O2 = 4',4'-dihydroxyechinenone + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033783", "l": "25-hydroxycholesterol 7alpha-hydroxylase activity", "d": ["Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O, and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805061", "l": "CK2 binds FACT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68048", "l": "[protein]-D-aspartate + S-adenosyl-L-methionine = [protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006508", "l": "PVALB gene expression is repressed by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13940", "l": "4-sulfobenzoate + NADH + O2 <=> 3,4-dihydroxybenzoate + NAD(+) + sulfite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51885", "l": "L-proline betaine => D-proline betaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372519", "l": "AcCho is hydrolyzed to Cho and acetate by ACHE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15431", "l": "5'-deoxyadenosine + anaerobilin + Fe(2+) + L-methionine + 2 oxidized [flavodoxin] + S-adenosyl-L-homocysteine => heme b + 2 reduced [flavodoxin] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626681", "l": "Recruitment of transition zone proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.6.-", "l": "\"With an nitrogenous group as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9620103", "l": "ALDH2 transforms GTN to NO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228943", "l": "Transcytosis and dissociation of botA:NTNHA:HA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17567", "l": "1D-1-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982637", "l": "Opsins binds G alpha-t (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193706", "l": "Production of ceramide which can activate JNK and other targets (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443783", "l": "Interaction of NUMB with L1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37031", "l": "D-ribonate = 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002039", "l": "p53 binding", "d": ["Binding to one of the p53 family of proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27796", "l": "all-trans-heptaprenyl diphosphate + 4 diphosphate => (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16144", "l": "2'-deoxymugineate + NAD(+) <=> 3''-deamino-3''-oxonicotianamine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54114", "l": "diphosphate + selina-4(15),7(11)-diene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36791", "l": "H2O + N(omega)-hydroxy-L-arginine = hydroxyurea + L-ornithine", "d": [], "t": []}, {"i": "EC:3.5.3.25", "l": "\"N(omega)-hydroxy-L-arginine amidinohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54182", "l": "a long-chain fatty acyl-[ACP] + H(+) + NADH => a long-chain fatty aldehyde + holo-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46952", "l": "2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.17.1.11", "l": "\"formate dehydrogenase (NAD(+), ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400204", "l": "PPARA binds RXRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72863", "l": "3',3',3'-cAAG + H2O = G[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008877", "l": "glucose-1-phosphatase activity", "d": ["Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13655", "l": "[6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose => [6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693356", "l": "CEMIP hydrolyses HA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706287", "l": "Active FLT3 binds to ABL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20044", "l": "3-oxopropanoate + H2O + NADP(+) <=> 2 H(+) + malonate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2130706", "l": "MHC class II antigen processing (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444572", "l": "Zinc is an agonist of GPR39 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036133", "l": "11-hydroxythromboxane B2 dehydrogenase activity", "d": ["Catalysis of the reaction: thromboxane B2 + NAD+ = 11-dehydro-thromboxane B2 + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696958", "l": "USP44 deubiquitinates CDC20 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22708", "l": "H2O + S-acylglutathione = a carboxylate + glutathione + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.7", "l": "\"glutathione thiolesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34375", "l": "4-guanidinobutanamide + H2O = 4-guanidinobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2214351", "l": "PLK1 phosphorylates GORASP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170674", "l": "Dissociation of the Gi alpha:G olf complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37523", "l": "(9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43505", "l": "5-hydroxymethylfurfural + O2 => 2,5-diformylfuran + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43661", "l": "ATP + hydrogencarbonate + propanoyl-CoA => ADP + H(+) + methylmalonyl-CoA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40369", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 4-phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61660", "l": "(2E)-geraniol + ATP = (2E)-geranyl phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37308", "l": "glycyl-L-asparagine + H2O => glycine + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24724", "l": "H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl(44)-[F-actin] + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40051", "l": "chorismate = 3-[(1-carboxyvinyl)-oxy]benzoate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.151", "l": "\"chorismate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73380", "l": "(R)-lipoate(out) + 2 Na(+)(out) => (R)-lipoate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62104", "l": "(9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49031", "l": "(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25167", "l": "A + butanoyl-CoA <=> (2E)-butenoyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68853", "l": "(2E,6E)-farnesyl diphosphate + H2O => (1S,6S,7R)-sesquipiperitol + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912505", "l": "Synapsis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14381", "l": "4-guanidinobutanal + H2O + NAD(+) = 4-guanidinobutanoate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.54", "l": "\"gamma-guanidinobutyraldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0034338", "l": "short-chain carboxylesterase activity", "d": ["Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37058", "l": "3-(4-hydroxyphenyl)pyruvate + dimethylallyl diphosphate <=> 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.53", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10325", "l": "an L-glycol + NADP(+) => a 2-hydroxycarbonyl + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9854368", "l": "ROS,RNS oxidize ACO2:4Fe-4S (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212352", "l": "Formation of ARC coactivator complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9754974", "l": "ADK phosphorylates RBV (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12419", "l": "beta-alanyl-CoA <=> acryloyl-CoA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-804969", "l": "HSD17B1 hydrogenates E1 to EST17b (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201637", "l": "Caspase-mediated cleavage of plectin-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18377", "l": "ATP + streptomycin = ADP + H(+) + streptomycin 3''-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.87", "l": "\"streptomycin 3''-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008288", "l": "boss receptor activity", "d": ["Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14373", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61169", "l": "quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose => H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31946", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73709", "l": "ATP(out) + UDP(in) => ATP(in) + UDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36007", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34166", "l": "hydroquinone + O2 <=> (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169398", "l": "ISGylation of host protein filamin B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878117", "l": "RUNX3 binds ZFHX3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.5", "l": "\"beta-aspartyl-peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707856", "l": "PGRMC2:Hemes dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48182", "l": "(2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73540", "l": "dCTP(out) + UTP(in) => dCTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44180", "l": "2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60377", "l": "D-glucose(out) => D-glucose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804955", "l": "ATM phosphorylates MDM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9860295", "l": "SLC15A4 binds TASL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964768", "l": "Addition of GlcNAc to the glycan on the A arm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59993", "l": "H(+) + oxidized [electron-transfer flavoprotein] + phloretate => (E)-4-coumarate + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2294600", "l": "CDK1 phosphorylates condensin II subunit NCAPD3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821368", "l": "AKAP8L binds MLL1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12484", "l": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.5", "l": "\"5'-nucleotidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166542", "l": "beta-NGF dimer binds to TrkA receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33960", "l": "2-oxoglutarate + neomycin C => 6'''-deamino-6'''-oxoneomycin C + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730892", "l": "Recruitment of VAV to p-SLP-76 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19621", "l": "a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106614", "l": "Duplex miRNA is loaded into Argonaute (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51652", "l": "D-mannonate + NAD(+) = H(+) + keto-D-tagaturonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033794", "l": "sarcosine reductase activity", "d": ["Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71528", "l": "thymine(out) => thymine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56843", "l": "5-amino-2-hydroxybenzoate + O2 <=> (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805730", "l": "SETD9 methylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016158", "l": "3-phytase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10305", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-[ACP] => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69096", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine = H2O + kynurenate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618093", "l": "ATP hydrolysis by HSP90 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62640", "l": "[mycoredoxin]-L-dithiol + a hydroperoxide = [mycoredoxin]-L-disulfide + an alcohol + H2O", "d": [], "t": []}, {"i": "EC:1.11.1.29", "l": "\"mycoredoxin-dependent peroxiredoxin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77487", "l": "4-methylpentan-2-one + hydrogen cyanide = (2S)-2-hydroxy-2,4-dimethylpentanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19156", "l": "apigenin 7-O-beta-D-glucoside + UDP-alpha-D-apiose <=> 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696958", "l": "USP44 deubiquitinates CDC20 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20887", "l": "H2O + L-serine + NAD(+) <=> 3-hydroxypyruvate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36489", "l": "H(+) + N(1)-(3-aminopropyl)agmatine + S-methyl-5'-thioadenosine => agmatine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114558", "l": "Thrombin-activated PARs activate Gq (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33207", "l": "ATP + H(+) + L-glutamate + NADPH = ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007625", "l": "RBBP8 gene expression is inhibited by E2F6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047664", "l": "aminoimidazolase activity", "d": ["Catalysis of the reaction:4-aminoimidazole + H20 = imidazol-4-one + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168950", "l": "TLR6:TLR2 is recruited to ligand:CD14:CD36 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050053", "l": "levansucrase activity", "d": ["Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53157", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(5,6-epoxy-8Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38169", "l": "CoA + hexadecanyl hexadecanoate => hexadecan-1-ol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856061", "l": "MITF-M-dependent CEACAM1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9761421", "l": "CDH11 associates with catenins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13340", "l": "D-glucurono-6,2-lactone + H2O <=> D-glucuronate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76824", "l": "H2O + methylamine + NAD(+) => formaldehyde + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67277", "l": "H2O + hexanal + NAD(+) => 2 H(+) + hexanoate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24245", "l": "NADP(+) + pseudotropine => H(+) + NADPH + tropinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14114", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O => a 3'-end 2'-deoxyribonucleotide-DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000309", "l": "nicotinamide-nucleotide adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.923250621671642", "identifiers": [{"i": "GO:0016247", "l": "channel regulator activity", "d": ["Binds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0031151", "l": "histone H3K79 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group to the lysine residue at position 79 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38504", "l": "a 1,3-diacyl-sn-glycerol + H2O => a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18372", "l": "O2 + sn-glycerol 3-phosphate <=> dihydroxyacetone phosphate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68141", "l": "2,5-hexanedione + 2 H(+) + 2 NADPH => (2R,5R)-hexanediol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73523", "l": "TTP(out) + UTP(in) = TTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37734", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine <=> 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033235", "l": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174251", "l": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9854463", "l": "SIRT3 deacetylates AcK-IDH2 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380508", "l": "Translocation of NuMA to the centrosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20581", "l": "H2O + NAD(+) + NH4(+) = 2 H(+) + hydroxylamine + NADH", "d": [], "t": []}, {"i": "EC:1.7.1.10", "l": "\"hydroxylamine reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2470555", "l": "Collagen type X binds Integrin alpha2beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390116", "l": "Phospho FT reduces D accumulation at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32646", "l": "2 Fe(III)-[cytochrome c] + H2O + lupanine <=> 17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77068", "l": "Activation of GT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482812", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME4) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61955", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 <=> CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388832", "l": "PI3K binds CD28 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64319", "l": "2 dihydrogeodin + 2 H(+) + O2 <=> 2 (+)-geodin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-189488", "l": "UROS transforms HMB to URO3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12791", "l": "an aldose + H(+) + NADPH => an alditol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2512800", "l": "SCARB1:ligand is endocytosed (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139842", "l": "Binding of Syk tyrosine kinase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050116", "l": "N,N-dimethylformamidase activity", "d": ["Catalysis of the reaction: N,N-dimethylformamide + H2O = dimethylamine + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66187", "l": "3',5'-cyclic AMP(in) + ATP + H2O <=> 3',5'-cyclic AMP(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482772", "l": "Release of platelet cytosolic components (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38658", "l": "6-tuliposide B <=> D-glucose + tulipalin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.69", "l": "\"gluconate 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177930", "l": "GAB1 phosphorylation by EGFR kinase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55959", "l": "(9Z)-octadecenoate + AH2 + O2 <=> (12R)-hydroxy-(9Z)-octadecenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709179", "l": "DPP4 binds DPP4 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199456", "l": "PTEN dephosphorylates PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27273", "l": "CoA + hexadecanal + NADP(+) <=> H(+) + hexadecanoyl-CoA + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22630", "l": "(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate => 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799332", "l": "ATR phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190260", "l": "FGFR2b binds to FGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617840", "l": "FOXO1,FOXO3,FOXO4 bind CDKN1A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10246", "l": "acetoacetate + fumarate + H(+) => 4-fumarylacetoacetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450770", "l": "MWH binds to RHO1:GTP and is activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047897", "l": "formate-dihydrofolate ligase activity", "d": ["Catalysis of the reaction: 7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375149", "l": "Interaction of NCAM1 with GFRalpha-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.91", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69118", "l": "3-(4-hydroxyphenyl)pyruvate + glycine => glyoxylate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43316", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58990", "l": "(E)-4-hydroxynon-2-enoate + H(+) + H2O2 => (E)-4-hydroxynon-2-enal + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675656", "l": "EDA:EDAR binds EDARADD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607744", "l": "MALT1 binds BCL10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20261", "l": "3,5,7-trioxododecanoyl-CoA = CO2 + CoA + olivetol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390912", "l": "HRH1 binds hist (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28000", "l": "H(+) + phosphate + thiamine phosphate => H2O + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32189", "l": "cholest-4-en-3-one => cholest-5-en-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432034", "l": "Aquaporin-6 passively transports anions into vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0047635", "l": "alanine-oxo-acid transaminase activity", "d": ["Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10533", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine => D-glyceraldehyde 3-phosphate + H2O + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45833", "l": "(3R)-3-hydroxydecanoyl-CoA + NAD(+) => 3-oxodecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217013", "l": "Phosphorylation of RAD51 by tyrosine kinase Abelson family protein members (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73762", "l": "guanosine(2553) in 23S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2553) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10908", "l": "3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74402", "l": "2 (S)-lactate(in) + prostaglandin F2alpha(out) <=> 2 (S)-lactate(out) + prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247844", "l": "WNT ligands traffic to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111439", "l": "Docking of Mature Histone mRNA complex:TAP at the NPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71889", "l": "H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide => GTP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1497853", "l": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23653", "l": "N-terminal L-glutaminyl-[peptide] => N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12860", "l": "(2S,3S)-3-methyl-L-aspartate <=> L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41396", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine = 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65473", "l": "2-methylbutanoyl-CoA + ethanol => CoA + ethyl 2-methylbutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19197", "l": "adenosine 5'-phosphosulfate + NH4(+) = adenosine 5'-phosphoramidate + 2 H(+) + sulfate", "d": [], "t": []}, {"i": "EC:2.7.7.51", "l": "\"adenylylsulfate--ammonia adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20972", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine = 1-O-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": [], "t": []}, {"i": "EC:2.3.1.148", "l": "\"glycerophospholipid acyltransferase (CoA-dependent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40566", "l": "dTDP-N-hydroxy-beta-L-evernosamine + H(+) + NADPH + O2 <=> dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20945", "l": "S-adenosyl-L-methionine + theobromine => caffeine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16785", "l": "an adenosine in tRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.55", "l": "\"tRNA (adenine-N(6)-)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0008200", "l": "ion channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of an ion channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18413", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.179", "l": "\"lactosylceramide beta-1,3-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2059926", "l": "NPHP4 protein binds LATS proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876484", "l": "NPC2 transfers CHOL to NPC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44889", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphate + H2O => 1-O-alkyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.24", "l": "\"aromatic desulfoglucosinolate sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379867", "l": "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59722", "l": "D-maltohexaonate + H(+) => D-maltohexaono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928640", "l": "PAKs phosphorylate MLC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27331", "l": "5-hydroxyisourate + H2O + NAD(+) => H(+) + NADH + O2 + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40471", "l": "(2S)-methylpentadecanoyl-CoA + O2 = 2-methyl-(2E)-pentadecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31778", "l": "all-trans-retinyl hexadecanoate + H2O <=> 11-cis-retinol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0046572", "l": "versicolorin B synthase activity", "d": ["Catalysis of the reaction: versiconal = versicolorin B + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24825", "l": "dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59952", "l": "2,6-dimethylheptanoyl-CoA + H2O = 2,6-dimethylheptanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.616479785166973", "identifiers": [{"i": "GO:0009982", "l": "pseudouridine synthase activity", "d": ["Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28215", "l": "[thioredoxin]-dithiol + prostaglandin H2 => [thioredoxin]-disulfide + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28438", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.204", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879562", "l": "SLCO2B1 has a narrow substrate specificity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749590", "l": "ASA- acetylates ALB (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012036", "l": "ME1 tetramer decarboxylates MAL to PYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52281", "l": "(6S)-5,6,7,8-tetrahydrofolate + 3-O-methylgallate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4,5-trihydroxybenzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23605", "l": "kievitone hydrate => H2O + kievitone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74361", "l": "coproporphyrin I(in) => coproporphyrin I(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61084", "l": "(2S)-naringenin + 2-oxoglutarate + O2 = (2R,3R)-dihydrokaempferol + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694265", "l": "nsp13 helicase melts secondary structures in SARS-CoV-2 genomic RNA template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12764", "l": "precorrin-3B + S-adenosyl-L-methionine <=> 3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59002", "l": "H(+) + H2O2 + propanoate => H2O + O2 + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-195280", "l": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71940", "l": "2-oxoglutarate(out) + 3 Na(+)(out) => 2-oxoglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69905", "l": "cytidine(in) + 2 Na(+)(in) => cytidine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44601", "l": "a fatty acid + ATP + H(+) => a fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25747", "l": "L-hexahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-hexahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43118", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-octanoyl-4-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-octanoylsphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37046", "l": "ATP + H2O + L-alanyl-L-glutamate(out) <=> ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047614", "l": "aconitate delta-isomerase activity", "d": ["Catalysis of the reaction: trans-aconitate = cis-aconitate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.332", "l": "\"bacteriochlorophyllide d C-8(2)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42644", "l": "2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] = diphosphate + holo-[malonate decarboxylase ACP]", "d": [], "t": []}, {"i": "EC:2.7.7.66", "l": "\"malonate decarboxylase holo-[acyl-carrier protein] synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013435", "l": "RHOD auto-activates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74805", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32559", "l": "(2E)-geranyl diphosphate = diphosphate + gamma-terpinene", "d": [], "t": []}, {"i": "EC:4.2.3.114", "l": "\"gamma-terpinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17945", "l": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.51", "l": "\"(S)-limonene 6-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78515", "l": "a 5'-end (5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35903", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19159", "l": "2-dehydro-3-deoxy-D-arabinonate + H2O => D-xylonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034952", "l": "malonate semialdehyde decarboxylase activity", "d": ["Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52975", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] <=> a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50291", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 <=> (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654603", "l": "Activated FGFR2 binds FRS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28257", "l": "(3Z)-hex-3-en-1-ol + acetyl-CoA <=> (3Z)-hex-3-en-1-yl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67985", "l": "N-acetyl-L-leucine => N-acetyl-D-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58921", "l": "(3S,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol => (+)-medicarpin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9709883", "l": "BIL:ALB scavenges O2.- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15366", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose => 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.96", "l": "\"diiodophenylpyruvate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20451", "l": "5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+) => 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222020", "l": "NUAK1 phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54530", "l": "D-ribose 5-phosphate => aldehydo-D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72307", "l": "L-glutamate(in) + taurocholate(out) = L-glutamate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981535", "l": "CD55 (DAF) binds C3bBb, C4bC2a (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851890", "l": "MET phosphorylates SHC1-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3814820", "l": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.125", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694575", "l": "Nucleoprotein translocates to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234165", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70536", "l": "GDP-beta-L-fucose + L-seryl-[EGF-like domain protein] => 3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48803", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose <=> a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57681", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] => a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31669", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9718379", "l": "GNRHR binds chemical antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22193", "l": "(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57573", "l": "7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39049", "l": "2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase] => 26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839396", "l": "TGFBR3 translation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050056", "l": "linalool 8-monooxygenase activity", "d": ["Catalysis of the reaction: linalool + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (6E)-8-oxolinalool + 2 H+ + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15658", "l": "1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) => 3-methylcatechol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76929", "l": "H(+) + NADPH + NH4(+) + pentan-3-one => 3-aminopentane + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961915", "l": "CDC45 gene expression is stimulated by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395801", "l": "Phosphorylation of LAT by p-SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809707", "l": "MTMR12 binds MTMR2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54156", "l": "2-oxoglutarate + [ribosomal protein uS12]-L-proline + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050385", "l": "ureidoglycolate lyase activity", "d": ["Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76415", "l": "3',3'-cGAMP(out) + n H(+)(out) = 3',3'-cGAMP(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43129", "l": "guanosine(10) in tRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75702", "l": "2 glutathione + NAD(+) <=> glutathione disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75090", "l": "Binding of ADAR1 homodimer to dsRNA duplex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47533", "l": "chenodeoxycholate + NAD(+) => 3-oxochenodeoxycholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48627", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 <=> (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75700", "l": "2 glutathione + NAD(+) => glutathione disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350168", "l": "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66925", "l": "[(R)-3-hydroxyalkanoate](n) + a (3R)-3-hydroxyacyl-CoA => [(R)-3-hydroxyalkanoate](n+1) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42276", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = (4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70998", "l": "L-cystine(out) + L-glutamate(in) <=> L-cystine(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37637", "l": "1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174124", "l": "Dephosphorylation of phospho-Cdh1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53680", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74168", "l": "H2O + N,N-dimethylglycine + oxidized 2[4Fe-4S]-[ferredoxin] => formaldehyde + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] + sarcosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75376", "l": "inosine(in) => inosine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028815", "l": "p-T,4S-IRF3:p-T,4S-IRF3:CREBBP, EP300 binds promoters of Interferon-beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59520", "l": "ATP + butanoyl-CoA + hydrogencarbonate = (2S)-ethylmalonyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44537", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51485", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68791", "l": "(2Z,6Z)-farnesyl diphosphate <=> (Z)-gamma-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551679", "l": "RANBP2 SUMOylates RANBP2 with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74570", "l": "L-glutamate(in) + N-acetyl-L-cysteine(out) <=> L-glutamate(out) + N-acetyl-L-cysteine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876484", "l": "NPC2 transfers CHOL to NPC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66037", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5228508", "l": "RANBP2 SUMOylates PML with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13339", "l": "D-glucuronate + H(+) => D-glucurono-6,2-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70592", "l": "PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48523", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + H2O <=> [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102158", "l": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA = H2O + a very-long-chain (2E)-enoyl-CoA. This reaction is the third (dehydration) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193643", "l": "PRDM4 (SC1) binds to p75NTR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76343", "l": "(2S)-2-isopropylmalate(in) + sulfate(out) = (2S)-2-isopropylmalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649724", "l": "LIG3:XRCC1, POLB, NEIL1,NEIL2 and PNKP dissociate from the BER site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29661", "l": "O-acetyl-L-serine(out) => O-acetyl-L-serine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692880", "l": "HRH3 binds Hist (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166175", "l": "TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75094", "l": "2 chloride(in) + sulfate(out) <=> 2 chloride(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9844057", "l": "SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47115", "l": "chenodeoxycholate + glycine <=> glycochenodeoxycholate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726580", "l": "PGR binds PGR agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2731078", "l": "Syndecans 2, (4) bind TGFB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39266", "l": "(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH <=> (13Z)-docosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61157", "l": "3'-dephospho-CoA + GTP => CoA + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18808", "l": "[DsbA protein]-disulfide + [protein]-dithiol <=> [DsbA protein]-dithiol + [protein]-disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194808", "l": "botF LC cleaves target cell VAMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40741", "l": "(20S)-ginsenoside C-Y + 2 D-glucose => (20S)-ginsenoside Rb2 + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41015", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol = 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205231", "l": "Dimerization of KIT upon SCF binding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74088", "l": "an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP => ADP + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9038052", "l": "GREB1 binds ESR1:ESTG and co-activators (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46447", "l": "(11Z)-hexadecenoyl-CoA + AH2 + O2 <=> (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176175", "l": "Stalling of DNA replication fork and RPA binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102612", "l": "syn-pimaradiene 6beta-hydroxylase activity", "d": ["Catalysis of the reaction: 9beta-pimara-7,15-diene + NADPH + O2 + H+ = 6beta-hydroxy-syn-pimaradiene + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52370", "l": "adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+) => 3'-phosphoadenylyl sulfate + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070009", "l": "serine-type aminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018639", "l": "xylene monooxygenase activity", "d": ["Catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111966", "l": "GRK2 binds CALM1:4Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67140", "l": "L-cysteinyl-[NO transferase protein] + N(omega)-hydroxy-L-arginine + O2 = H(+) + H2O + L-citrulline + S-nitroso-L-cysteinyl-[NO transferase protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19617", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58561", "l": "15alpha-stemmadenine intermediate II + NADP(+) => 15alpha-stemmadenine intermediate I + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55874", "l": "2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH => anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9709098", "l": "DHFR dimer reduces FOLA to DHF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60625", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 (9Z)-octadecenoate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.11", "l": "\"3-oxo-Delta(1)-steroid hydratase/dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824732", "l": "G or G analog binds C-ter TLR7 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34034", "l": "2'-N-acetylparomamine + H2O <=> acetate + paromamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759445", "l": "PREDN,PREDL diffuse into kidney cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74062", "l": "beta-alanine(out) + L-alanine(in) <=> beta-alanine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9710959", "l": "p-STAT1 dimer binds KPNA1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606564", "l": "GALC hydrolyzes GalCer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73222", "l": "L-xylopyranose(out) + 2 Na(+)(out) <=> L-xylopyranose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-965067", "l": "THTPA:Mg2+ hydrolyzes ThTP to TDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167197", "l": "Separation of elongating HIV-1 transcript from template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017131", "l": "uridine-rich cytoplasmic polyadenylylation element binding", "d": ["Binding to a U-rich sequence in the 3'-end of nuclear-transcribed mRNAs; required for cytoplasmic polyadenylylation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41278", "l": "H2O + N-eicosanoyl-sphing-4-enine <=> eicosanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.20", "l": "\"beta-Ala-His dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467794", "l": "Resolution of sister chromatids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9718379", "l": "GNRHR binds chemical antagonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11570", "l": "5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67074", "l": "a very long-chain fatty acid + CoA + H(+) => a very long-chain fatty acyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16131", "l": "H(+) + NADPH + pyridoxal => NADP(+) + pyridoxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31911", "l": "beta-D-fructose 1,6-bisphosphate + methylglyoxal = 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0003976", "l": "UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009282", "l": "CDK1 phosphorylates RUNX2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202165", "l": "Phosphorylation of ITAM motifs in CD3 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59376", "l": "4-amino-4-deoxychorismate = 4-amino-4-deoxyprephenate", "d": [], "t": []}, {"i": "EC:5.4.99.67", "l": "\"4-amino-4-deoxychorismate mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034956", "l": "diphenyl ether 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60635", "l": "all-trans-4-oxoretinol + NAD(+) <=> all-trans-4-oxoretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28802", "l": "H2O + L-prolinylglycine <=> glycine + L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44220", "l": "15-hydroxypentadecanoate + ATP + CoA = 15-hydroxypentadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10117", "l": "6-phospho-D-gluconate + NADP(+) => CO2 + D-ribulose 5-phosphate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090523", "l": "cytochrome-b5 reductase activity, acting on NADPH", "d": ["Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome b(5) = NADP+ + 2 ferrocytochrome b(5)."], "t": []}, {"i": "RHEA:64576", "l": "2 Fe(III)-[cytochrome b5] + NADPH = 2 Fe(II)-[cytochrome b5] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60138", "l": "a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate => a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76078", "l": "a dicarboxylate(in) + L-erythro-7,8-dihydrobiopterin(out) <=> a dicarboxylate(out) + L-erythro-7,8-dihydrobiopterin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34379", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 UDP-alpha-D-galactofuranose = beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 2 H(+) + 2 UDP", "d": [], "t": []}, {"i": "EC:2.4.1.287", "l": "\"rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,4/1,5-galactofuranosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786650", "l": "DDHD1,2 hydrolyse PA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23931", "l": "H2O + N(8)-acetylspermidine <=> acetate + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33078", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine <=> 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855217", "l": "I(1,4,5)P3 transports from the ER lumen to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17158", "l": "ATP + creatine => ADP + H(+) + N-phosphocreatine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51788", "l": "2-hydroxybenzoyl-5'-AMP + CoA = 2-hydroxybenzoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606883", "l": "CD19 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428625", "l": "Vesicular inhibitory amino acid transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23431", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate <=> 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009485", "l": "IL34:CSF1 binds CSF1R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47852", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18056", "l": "H2O + paraoxon <=> 4-nitrophenol + diethylphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2473596", "l": "Collagen type I degradation by MMP15 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9834070", "l": "PRKN ubiquitinates MOM substrates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62310", "l": "(+)-malbrancheamide B + FADH2 => (+)-premalbrancheamide + chloride + FAD + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9824892", "l": "MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66558", "l": "5-dopaminyl-L-glutamyl-[protein] + NH4(+) => dopamine + L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30817", "l": "beta-nicotinamide D-riboside + phosphate => beta-nicotinamide D-ribonucleotide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140772", "l": "CoA-dependent peptidyl-lysine N6-palmitoyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + hexadecanoyl-CoA = CoA + H+ + N(6)-hexadecanoyl-L-lysyl-[protein]."], "t": []}, {"i": "RHEA:59768", "l": "hexadecanoyl-CoA + L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein] = CoA + H(+) + N(6)-hexadecanoyl-L-lysyl-/S-(2E,6E,10E)-geranylgeranyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21535", "l": "ATP + glutathione + glutathionylspermidine <=> ADP + H(+) + phosphate + trypanothione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60637", "l": "N-(dodecanoyl)-sphing-4-enine-1-phosphocholine => choline + N-dodecanoyl-sphing-4-enine-1,3-cyclic phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25256", "l": "ATP + N-acetyl-D-mannosamine <=> ADP + H(+) + N-acetyl-D-mannosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57731", "l": "H(+) + trans-aconitate <=> CO2 + itaconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58137", "l": "acetate + ATP + H(+) => acetyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71430", "l": "3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) <=> 3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168310", "l": "Release of the RNP into the host cell nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18860", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9716160", "l": "SARS-CoV-2 M protein binds MAVS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29848", "l": "(2E)-tetradecenoyl-CoA => (3Z)-tetradecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22743", "l": "a D-hexose + ATP <=> a D-hexose 6-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13416", "l": "ADP + thymidine <=> AMP + dTMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193533", "l": "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11560", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) = catechol + CO2 + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.25", "l": "\"1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24580", "l": "D-sorbitol 6-phosphate + H2O = D-sorbitol + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.50", "l": "\"sorbitol-6-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033826", "l": "xyloglucan 4-glucosyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73861", "l": "1-methylnicotinamide(in) => 1-methylnicotinamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42592", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42514", "l": "5-aminopentanoate + acetate => 5-acetamidopentanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9825783", "l": "p-S207 KARS1 dimer translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18061", "l": "5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": [], "t": []}, {"i": "EC:2.3.1.101", "l": "\"formylmethanofuran--tetrahydromethanopterin N-formyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72983", "l": "dimethylallyl diphosphate + harmol = 6-(3-dimethylallyl)harmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35475", "l": "(1'S,5'S)-5'-hydroxyaverantin + NAD(+) = (S)-5'-oxoaverantin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78029", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59250", "l": "(E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950347", "l": "IL12A:IL12B translocates from late endosome lumen to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990882", "l": "CDK1 phosphorylates NUP98 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60394", "l": "Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) => Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62220", "l": "phyllostine = neopatulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63539", "l": "bradykinin(1-8) + H2O <=> bradykinin(1-7) + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47978", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73439", "l": "(2S)-naringenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-carthamidin-4',7-dimethyl ether + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140314", "l": "calcium ion sequestering activity", "d": ["Binding to a calcium ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39080", "l": "(3S)-hydroxydodecanedioyl-CoA + NAD(+) => 3-oxododecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005140", "l": "interleukin-9 receptor binding", "d": ["Binding to an interleukin-9 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75641", "l": "(12S,13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoate => (8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25511", "l": "(2E)-geranyl diphosphate <=> (1S,5S)-sabinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47005", "l": "H2O + O-phospho-L-threonyl-[protein] => L-threonyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74741", "l": "7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine => 3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015430", "l": "ABC-type glycerol-3-phosphate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218821", "l": "PDK1 phosphorylates PKC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450348", "l": "Activated human JNKs migrate to nucleoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56905", "l": "an acyl-AMP + CoA => AMP + an acyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52644", "l": "D-xylono-1,4-lactone 5-phosphate + H2O = 5-phospho-D-xylonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042500", "l": "aspartic endopeptidase activity, intramembrane cleaving", "d": ["Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52575", "l": "butanoyl-CoA + NAD(+) <=> (2E)-butenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391941", "l": "BLT receptors can bind LTB4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57840", "l": "1D-myo-inositol 1,3-bisphosphate + H2O = 1D-myo-inositol 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55622", "l": "a carotenoid beta-end derivative => a carotenoid psi-end group", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38892", "l": "H2O + N-hexadecanoylsphing-4-enine => hexadecanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42472", "l": "dibenzo-p-dioxin + NADH + O2 = 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23064", "l": "an alkanesulfonate + FMNH2 + O2 = an aldehyde + FMN + 2 H(+) + H2O + sulfite", "d": [], "t": []}, {"i": "EC:1.14.14.5", "l": "\"alkanesulfonate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17493", "l": "A + glycerol = AH2 + dihydroxyacetone", "d": [], "t": []}, {"i": "EC:1.1.99.22", "l": "\"glycerol dehydrogenase (acceptor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34649", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877153", "l": "STARD7 binds PC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14290", "l": "a dicarboxylate + ATP + CoA => AMP + diphosphate + omega-dicarboxyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17452", "l": "(2E)-geranyl diphosphate + flaviolin <=> 3-linalylflaviolin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265301", "l": "Corticotropin cleavage from POMC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41827", "l": "3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxyhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54827", "l": "H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] <=> alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24302", "l": "2 cob(II)yrinate a,c diamide + FMNH2 => 2 cob(I)yrinate a,c diamide + FMN + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53354", "l": "H(+) + NADH + uridine(20b) in tRNA => 5,6-dihydrouridine(20b) in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733545", "l": "Bile salts and acids bind ALB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1912357", "l": "ITCH ubiquitinates DTX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626848", "l": "S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71954", "l": "3 Na(+)(out) + sulfate(out) <=> 3 Na(+)(in) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48321", "l": "a ganglioside GA1 + GDP-beta-L-fucose => a ganglioside Fuc-GA1 + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28758", "l": "a ubiquinone + sn-glycerol 3-phosphate <=> a ubiquinol + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59407", "l": "L-homoserine <=> D-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19674", "l": "1,2,3-trihydroxybenzene + O2 => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672961", "l": "PP2A dephosphorylates inactive RAFs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033221", "l": "ATPase-coupled urea transmembrane transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in)."], "t": []}, {"i": "RHEA:32803", "l": "ATP + H2O + urea(out) = ADP + H(+) + phosphate + urea(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008948", "l": "oxaloacetate decarboxylase activity", "d": ["Catalysis of the reaction: oxaloacetate = pyruvate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28099", "l": "ATP + GDP => AMP + guanosine 3',5'-bis(diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863727", "l": "STON2 is neddylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72821", "l": "L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out) => L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50668", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.344", "l": "\"type 2 galactoside alpha-(1,2)-fucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9633044", "l": "ESR binds STRN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49620", "l": "D-erythritol 1-phosphate + NADP(+) = D-erythrulose 1-phosphate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.402", "l": "\"D-erythritol 1-phosphate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140984", "l": "histone H4K12 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 12) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 12). This reaction is the addition of a methyl group to the lysine residue at position 12 of the histone H4 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390912", "l": "HRH1 binds hist (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23947", "l": "(E)-coniferol + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-(E)-coniferol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.66", "l": "\"choriolysin L\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0005237", "l": "inhibitory extracellular ligand-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070530", "l": "K63-linked polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140871", "l": "repressor of RNA polymerase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of an RNA polymerase inhibitor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17882", "l": "H2O + N-sulfo-D-glucosamine => D-glucosamine + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36496", "l": "alpha-D-glucose + ATP => ADP + alpha-D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51695", "l": "prephenate + S-adenosyl-L-methionine <=> 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865613", "l": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696131", "l": "AOC1 deaminates Hist (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211224", "l": "Association of DFF40 with DFF45 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6798374", "l": "DYRK2 phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010541", "l": "ISL1 binds the SLIT2 gene enhancer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140870", "l": "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76264", "l": "ergothioneine(in) => ergothioneine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15637", "l": "[alginate](n) + GDP-alpha-D-mannuronate = [alginate](n+1) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70462", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in single-stranded DNA + H2O + O2 <=> a 2'-deoxyadenosine in single-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706298", "l": "Active FLT3 binds to CSK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41102", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47691", "l": "cis-4-hydroxy-L-proline + NADP(+) <=> Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71155", "l": "TAT deaminates tyrosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40915", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37086", "l": "[sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine <=> [sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15678", "l": "5-aminopentanamide + H2O => 5-aminopentanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446322", "l": "PARVA associates with Paxillin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418925", "l": "ADORA2A,B bind Ade-Rib (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928631", "l": "GIT1 binds bPIX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69308", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate = phenylacetonitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400434", "l": "FFAR1 binds fatty acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48566", "l": "D-ribose 5-phosphate + trans-zeatin => 9-ribosyl-trans-zeatin 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47359", "l": "an octanoate ester + H2O <=> an aliphatic alcohol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32043", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate = 2 ATP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5671702", "l": "AP1G2 binds HGS and CHMP2A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950387", "l": "CANX binds EBI3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004968", "l": "gonadotropin-releasing hormone receptor activity", "d": ["Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22972", "l": "butanal + CoA + NADP(+) = butanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57959", "l": "dimethyl sulfoxide + H(+) + NADH + O2 <=> dimethyl sulfone + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070034", "l": "telomerase RNA binding", "d": ["Binding to the telomerase RNA template."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52807", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-eremophilene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5633460", "l": "MDM2 binds TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222655", "l": "AhpD reactivates AhpC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667456", "l": "AVPR1A,B bind desmopressin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47483", "l": "deoxycholate + NADP(+) <=> 12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15193", "l": "dGTP + H2O = 2'-deoxyguanosine + H(+) + triphosphate", "d": [], "t": []}, {"i": "EC:3.1.5.1", "l": "\"dGTPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3244643", "l": "STING binds cyclic GMP-AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66549", "l": "3'-phosphoadenylyl sulfate + 4-nitrophenol => 4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429497", "l": "SLP-76 stimulates PLC gamma 2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047539", "l": "2-deoxyglucosidase activity", "d": ["Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57506", "l": "pyruvate + succinate => 3-hydroxybutane-1,2,3-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38898", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) <=> a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41933", "l": "H2O + hexadecanoyl-[ACP] => H(+) + hexadecanoate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55063", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 12-oxojasmonyl-L-alpha-amino acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804527", "l": "INTL1 binds bacterial glycans (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9842651", "l": "Active LTK receptor phosphorylates SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65295", "l": "2 ATP + butan-2-one + 3 H2O + hydrogencarbonate <=> 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32560", "l": "(2E)-geranyl diphosphate => diphosphate + gamma-terpinene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669878", "l": "Sunitinib-resistant KIT mutants do not bind sunitinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72446", "l": "(E)-feruloyl-AMP + CoA <=> (E)-feruloyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050400", "l": "xylitol kinase activity", "d": ["Catalysis of the reaction: ATP + xylitol = ADP + 2 H+ + xylitol 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030160", "l": "synaptic receptor adaptor activity", "d": ["The binding activity of a molecule that provides a physical support bridging a synaptic signaling receptor and a downstream signaling molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625913", "l": "Hypochlorous acid (HOCL) reacts with Lys-monochloramine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632970", "l": "MSH6 variant:MSH2-defective DNA mismatch repair (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9671145", "l": "DKC1 binds SHQ1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004132", "l": "dCMP deaminase activity", "d": ["Catalysis of the reaction: dCMP + H2O = dUMP + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25277", "l": "3',5'-cyclic AMP + H2O = AMP + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.53", "l": "\"3',5'-cyclic-AMP phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39267", "l": "(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140777", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983156", "l": "Polyubiquitination of substrate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42678", "l": "H2O + L-alanin-3-yl L-histidin-5-yl sulfoxide => L-cysteine + L-histidine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66386", "l": "scalar-17(25)-en-19-ol => (2E,6E,10E,14E)-geranylfarnesol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876484", "l": "NPC2 transfers CHOL to NPC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-186780", "l": "PI3-kinase binds to the active receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37036", "l": "H2O + L-2-aminopentanoate + NAD(+) => 2-oxopentanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54604", "l": "2-oxoglutarate + decanoyl-CoA + O2 = 2-hydroxydecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879459", "l": "F-actin capping protein is a heterodimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50745", "l": "2 glyphosate + O2 => 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112037", "l": "Inactivation of PLC beta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52490", "l": "20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047160", "l": "alkylglycerophosphate 2-O-acetyltransferase activity", "d": ["Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69992", "l": "3-dehydro-6-deoxoteasterone + NADP(+) => (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52430", "l": "12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+) => 12-oxo-leukotriene B4 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65001", "l": "holo-[ACP] + octanoyl-AMP => AMP + H(+) + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203680", "l": "eNOS:NOSIP translocation from caveolae to intracellular compartments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73932", "l": "chloride + FADH2 + griseophenone C + O2 => FAD + griseophenone B + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24198", "l": "(2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+) => (2R,4S)-2,4-diaminopentanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700171", "l": "Active ALK phosphorylates PLCG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382052", "l": "p130Cas and C3G bind PDGFR bound Crk (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21038", "l": "acetoacetyl-CoA + CoA => 2 acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19878", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77878", "l": "(2S)-4-methyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]pentanoate + H(+) + H2O <=> 2-dehydro-D-glucose + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944254", "l": "Association of procollagen type XXVI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856737", "l": "Unknown enzyme(s) process 4-HMA to 4-Hbz (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26352", "l": "beta-L-galactose 1-phosphate + H2O <=> L-galactose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008412", "l": "4-hydroxybenzoate octaprenyltransferase activity", "d": ["Catalysis of the reaction: farnesylfarnesylgeranyl diphosphate + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77370", "l": "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + CMP-N-acetyl-beta-neuraminate <=> [N-acetyl-alpha-D-neuraminosyl-(2->8)](n+1) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65761", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a 17alpha-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033941", "l": "mannan exo-1,2-1,6-alpha-mannosidase activity", "d": ["Catalysis of the hydrolysis of (1->2)-alpha-D- and (1->6)-alpha-D- linkages in mannan, releasing D-mannose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018794", "l": "RHOV binds effectors at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139917", "l": "tBID activates BAX protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16661", "l": "fluoride + S-adenosyl-L-methionine = 5'-deoxy-5'-fluoroadenosine + L-methionine", "d": [], "t": []}, {"i": "EC:2.5.1.63", "l": "\"adenosyl-fluoride synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38917", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75131", "l": "neomorphinone = morphinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28544", "l": "CoA + fluoroacetate + H(+) => fluoroacetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25651", "l": "(6R)-isopiperitenone + H(+) + NADPH => (2R,5R)-isopulegone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72697", "l": "Start codon recognition (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17576", "l": "demethylmacrocin + S-adenosyl-L-methionine <=> H(+) + macrocin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77081", "l": "Formation of the CE:GMP intermediate complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28150", "l": "acetyl-CoA + spermidine = CoA + H(+) + N(1)-acetylspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624954", "l": "INPP5E translocates to the primary cilium (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199014", "l": "CD96 binds PVR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47744", "l": "demethylphylloquinone + H(+) + NADPH = demethylphylloquinol + NADP(+)", "d": [], "t": []}, {"i": "EC:1.6.5.12", "l": "\"demethylphylloquinone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655483", "l": "USP1 autocleavage (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43639", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9732097", "l": "FOXD3 binds PAX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27938", "l": "(3R)-3-hydroxy-D-aspartate = glycine + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080107", "l": "8-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 8-methylthiopropyl-glucosinolate = 8-methylsulfinylpropyl-glucosinolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40701", "l": "1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76110", "l": "(11R)-methyl carlactonoate + 2-oxoglutarate + O2 <=> (11R)-hydroxymethyl carlactonoate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24201", "l": "4-aminobenzoate + H(+) => aniline + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592240", "l": "Formation of NRF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110248", "l": "Cleavage of 3-methyladenine by MPG glycosylase  (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10665", "l": "NAD(+) + perillyl alcohol => H(+) + NADH + perillyl aldehyde", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53920", "l": "ATP + L-threonyl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651685", "l": "Defective SLC34A1 does not cotransport Pi, 3Na+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.160", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19521", "l": "acetyl-CoA + phosphate = acetyl phosphate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.8", "l": "\"phosphate acetyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669013", "l": "EDA-3 binds EDA2R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42743", "l": "guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33164", "l": "beta-nicotinamide D-riboside(in) => beta-nicotinamide D-riboside(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9861640", "l": "CTLH E3 ligase ubiquitinates PKM-1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77077", "l": "Capping complex formation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725332", "l": "MYC/MYCN bind the ALK gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62448", "l": "holo-[peptidyl-carrier protein] + L-glutamyl-5'-AMP = AMP + H(+) + L-glutamyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56429", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678313", "l": "AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65757", "l": "2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] => (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31174", "l": "(3S)-hydroxytetradecanoyl-CoA <=> (2E)-tetradecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295632", "l": "PPA2A dephosphorylates SPRY2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018581", "l": "hydroxyquinol 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate + 2 H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75375", "l": "inosine(in) = inosine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047680", "l": "aryl-acylamidase activity", "d": ["Catalysis of the reaction: anilide + H2O = a carboxylate + aniline + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61612", "l": "2-oxoglutarate + 7-deoxycylindrospermopsin + O2 = 7-epi-cylindrospermopsin + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71397", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate(in) => (5Z,8Z,11Z,14Z)-eicosatetraenoate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77085", "l": "10-hydroxy-pre-flavunoidine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pre-flavunoidine + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76623", "l": "(R)-2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38853", "l": "H2O + tetracenomycin F1 => H(+) + tetracenomycin F2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876472", "l": "NPC2 binds CHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20679", "l": "1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP => alizarin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191402", "l": "Reduction of presqualene diphosphate to form squalene (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76143", "l": "picrinine + S-adenosyl-L-methionine = ervincine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086200", "l": "Dentin matrix protein 1 binds integrin alphaVbeta3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390909", "l": "HRH2 binds hist (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022186", "l": "SLC2A3 gene expression is stimulated by MECP2:CREB1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23562", "l": "adenosylcob(III)alamin 5'-phosphate + GMP + H(+) => adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9671145", "l": "DKC1 binds SHQ1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047231", "l": "pyridoxine 5'-O-beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H+ + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696465", "l": "USP45 deubiquitinates ERCC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392530", "l": "p-S400-Cot phosphorylates NIK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8878654", "l": "ACP6 hydrolyses MYS-LPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.66", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166214", "l": "FA anion flip-flops to the opposite surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004687", "l": "myosin light chain kinase activity", "d": ["Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-688137", "l": "RIP2 is K63 polyubiquitinated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199161", "l": "Fc gamma receptors interact with antigen-bound IgG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39716", "l": "(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + AH2 + O2 => (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62223", "l": "phyllostine <=> neopatulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66065", "l": "2-oxohexanoate + L-kynurenine => 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56207", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] <=> 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67150", "l": "2 H2O + L-citrulline + NADP(+) + S-nitroso-L-cysteinyl-[NO transferase protein] => L-arginine + L-cysteinyl-[NO transferase protein] + NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5221061", "l": "TDG excises 5-carboxylcytosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874718", "l": "TTPA binds alpha-TOH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61349", "l": "ATP + estrone 3-sulfate(in) + H2O => ADP + estrone 3-sulfate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102827", "l": "galactosylononitol-raffinose galactosyltransferase activity", "d": ["Catalysis of the reaction: raffinose + D-galactosylononitol = stachyose + 1D-4-O-methyl-myo-inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1237129", "l": "Acireductone is created (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203712", "l": "eNOS associates with Caveolin-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57583", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> S-methyl-1-thiol-D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201608", "l": "Caspase-mediated cleavage of alpha adducin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54528", "l": "aldehydo-D-ribose 5-phosphate = D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183052", "l": "CBL binds to GRB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980061", "l": "JAG2 binds NOTCH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164381", "l": "G alpha (s) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57002", "l": "CoA + H(+) + N(beta)-acetylstreptothricin F => acetyl-CoA + streptothricin F", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1370500", "l": "PRLR binds SCF beta-TrCP complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31748", "l": "3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + H2O + NADP(+) => 3-oxo-5,6-didehydrosuberyl-CoA + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102056", "l": "11-hydroxyjasmonate sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + an 11-hydroxyjasmonate = adenosine 3',5'-bismonophosphate + H+ + an 11-hydroxyjasmonate sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624120", "l": "CEBPA binds CDK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27448", "l": "NADP(+) + xylitol <=> D-xylose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004109", "l": "coproporphyrinogen oxidase activity", "d": ["Catalysis of the reaction: coproporphyrinogen III + 2 H+ + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944263", "l": "Association of procollagen type II (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625745", "l": "PKN1 stimulates association of AR with NCOA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16983", "l": "H(+) + maleylacetate + NADH => 3-oxoadipate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4755479", "l": "SUMOylation of NFKB2 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11599", "l": "H(+) + orotidine 5'-phosphate <=> CO2 + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210289", "l": "Recruitment of SYK to p-DAP12 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40571", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78969", "l": "a 1,2-diacyl-sn-glycerol + glycerol 1-phosphate + H(+) => a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959462", "l": "SAMD8 transfers phosphatidyl from PE onto C16DH CER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944261", "l": "Association of procollagen type XIII (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54329", "l": "2 H(+) + hexadecanoyl-[ACP] + 2 NADPH => hexadecan-1-ol + holo-[ACP] + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654425", "l": "Activated FGFR4 binds SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33461", "l": "NADP(+) + zymosterol => H(+) + NADPH + zymosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32390", "l": "dihydrocarveol + NAD(+) <=> dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16625", "l": "acetyl-CoA + hydrogen sulfide = CoA + thioacetate", "d": [], "t": []}, {"i": "EC:2.3.1.10", "l": "\"hydrogen-sulfide S-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72862", "l": "3',3',3'-c-tri-AMP + H2O <=> A[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69242", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => glucoraphanin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37687", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70085", "l": "H2O + o-quinone methide => hydroxyclavatol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75936", "l": "ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine => 6-O-phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050255", "l": "ribitol 2-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: D-ribitol + NAD+ = D-ribulose + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32128", "l": "2-oxoglutarate + L-proline + O2 => cis-4-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55789", "l": "acetone + H(+) + NADH + O2 => H2O + hydroxyacetone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507719", "l": "p62:MEKK3 binds to TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11666", "l": "1,2-diacyl-3-[3-(N-acetyl-alpha-D-neuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+) => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11913", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) => 15-oxoprostaglandin E2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22560", "l": "(3R)-vestitone + NADP(+) = 2'-hydroxyformononetin + 2 H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.45", "l": "\"2'-hydroxyisoflavone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-203973", "l": "Vesicle budding (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.422", "l": "\"pseudoephedrine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74956", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + holo-[ACP] => a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47030", "l": "[DsrC protein]-disulfide + H(+) + sulfite => [DsrC protein]-S-sulfo-L-cysteine/L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19849", "l": "H2O + NADP(+) = ADP-D-ribose 2'-phosphate + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0009669", "l": "sucrose:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52143", "l": "a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O <=> a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222128", "l": "NOC2L binds TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13068", "l": "ATP + H2O <=> ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71240", "l": "2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH => 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34185", "l": "alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+) => alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987223", "l": "IL10RB binds TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878013", "l": "RUNX2 and SMAD1 complex binds the SMAD6 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35893", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73323", "l": "(2R,3S)-piscidate + (E)-caffeoyl-CoA = cimicifugate D + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.12", "l": "\"acyl-lipid omega-(9-4) desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694527", "l": "Loss of SAR1B GTPase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193743", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30992", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] => 24-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36539", "l": "hexadecanoyl-CoA + sphinganine = CoA + H(+) + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017835", "l": "NOTCH1 coactivator complex binds NOTCH3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36868", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77850", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-tyrosine + O2 <=> (2S)-3-(4-hydroxyphenyl)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67038", "l": "(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + CO2 + succinate => (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55643", "l": "C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate <=> AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030354", "l": "melanin-concentrating hormone activity", "d": ["The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43998", "l": "a 2-hydroxy-3-methyl fatty acyl-CoA + CO2 + succinate => 2-oxoglutarate + a 3-methyl fatty acyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791133", "l": "Expression of Sec31A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52925", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate => 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30887", "l": "4-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin = 7,8-dihydropteroate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374896", "l": "Uptake of Noradrenaline (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63866", "l": "(2R)-2-hydroperoxyoctadecanoate => O2 + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102441", "l": "syringetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine = 7,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20586", "l": "loganin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30207", "l": "H2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]", "d": [], "t": []}, {"i": "EC:1.4.9.1", "l": "\"methylamine dehydrogenase (amicyanin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24642", "l": "D-glucose + ergosterol => ergosteryl 3-beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627350", "l": "SMAC (DIABLO) binds XIAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49560", "l": "D-sedoheptulose 7-phosphate = (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.154", "l": "\"demethyl-4-deoxygadusol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564143", "l": "Collagen type X degradation by MMP1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052631", "l": "sphingolipid 8-(E/Z)-desaturase activity", "d": ["Catalysis of the reaction: an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O or an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = (4R,8Z)-4-hydroxysphing-8-enine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O. This results in the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41339", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73432", "l": "(2S)-sakuranetin + O2 + reduced [NADPH--hemoprotein reductase] => (2S)-7-methylcarthamidin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57280", "l": "a guanosine in RNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008097", "l": "5S rRNA binding", "d": ["Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66347", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10083", "l": "dihydrophloroglucinol + NADP(+) <=> 1,3,5-trihydroxybenzene + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404200", "l": "IGF1,2 binds IGF1R (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37284", "l": "H2O + L-alanyl-L-histidine => L-alanine + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18035", "l": "4-hydroxybenzoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => benzoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62065", "l": "2-deoxy-D-glucose 6-phosphate + NAD(+) => 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11830", "l": "a 3'-end 2'-phospho-ribonucleotide-RNA + H(+) => a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183055", "l": "Binding of CBL to EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22179", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.25.-", "l": "\"Threonine endopeptidases\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667111", "l": "PARK2 K63-Ubiquitinates SNCAIP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.11", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67707", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015350", "l": "methotrexate transmembrane transporter activity", "d": ["Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52077", "l": "13-(9Z-hexadecenoyloxy)-octadecanoate + H2O => (9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74711", "l": "Phosphorylation of IRS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015371", "l": "galactose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29766", "l": "ATP + H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) <=> ADP + H(+) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507873", "l": "Aquaporins passively transport urea out of cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76162", "l": "fluoride(in) <=> fluoride(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451757", "l": "Heterodimerization of nephrin and KIRREL2, KIRREL3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10932", "l": "ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.4.5", "l": "\"argininosuccinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5618107", "l": "ATP binding to HSP90 triggers conformation change (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62756", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64058", "l": "(R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1S,2R)-ephedrine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296045", "l": "Activation of Potassium transport channels (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74730", "l": "Insulin degradation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18244", "l": "D-lysine <=> (2R,5S)-2,5-diaminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72822", "l": "L-ornithine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) <=> L-ornithine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420128", "l": "SRC-1 phosphorylates SHB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72479", "l": "citrate(out) + trans-aconitate(in) = citrate(in) + trans-aconitate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983144", "l": "Transport of Antigen peptide in to ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39934", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13659", "l": "acetate + H(+) + holo-[citrate lyase ACP] => acetyl-[citrate lyase ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61395", "l": "ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71400", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxusin => 2alpha-hydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38072", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008691", "l": "3-hydroxybutyryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047763", "l": "caffeate O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47195", "l": "coenzyme M + methyl-Co(III)-[methylated-thiol-specific corrinoid protein] <=> Co(I)-[methylated-thiol-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51756", "l": "a 2-acyl-4-prenylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4,6-diprenylphloroglucinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22003", "l": "D-xylose + NADP(+) <=> D-xylono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2106586", "l": "WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37895", "l": "H2O + protodioscin = 26-deglucoprotodioscin + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.186", "l": "\"protodioscin 26-O-beta-D-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686088", "l": "CASP3 cleaves GSDMD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32078", "l": "geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65957", "l": "ATP + estrone 3-sulfate(out) + H2O => ADP + estrone 3-sulfate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27635", "l": "5-dehydro-D-gluconate + NADP(+) => 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18165", "l": "biphenyl + H(+) + NADH + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.18", "l": "\"biphenyl 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44184", "l": "D-sedoheptulose 7-phosphate = 2-epi-5-epi-valiolone + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.152", "l": "\"2-epi-5-epi-valiolone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709547", "l": "ESTG binds ESR2:chaperone complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766532", "l": "SQSTM1 oligomer is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015501", "l": "glutamate:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55215", "l": "(2R)-hydroxyhexadecanoyl-CoA <=> formyl-CoA + pentadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.329", "l": "\"2-deoxy-scyllo-inosamine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666425", "l": "p-6Y-SYK phosphorylates VAV1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9838627", "l": "AFG3L2 binds mitochondrial inner membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192061", "l": "CYP46A1 24-hydroxylates CHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56862", "l": "a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP] => a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59491", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate <=> ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10120", "l": "adenosine in double-stranded RNA + H(+) + H2O = inosine in double-stranded RNA + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.37", "l": "\"double-stranded RNA adenine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161790", "l": "20cooh-LTB4 is converted to 18cooh-LTB4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696049", "l": "ADPRM hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3772434", "l": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043185", "l": "vascular endothelial growth factor receptor 3 binding", "d": ["Binding to a vascular endothelial growth factor receptor 3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55349", "l": "all-trans-retinol => 9-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015117", "l": "thiosulfate transmembrane transporter activity", "d": ["Enables the transfer of thiosulfate ions, HS2O3(1-), from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2396399", "l": "Fibrillins bind BMPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19755", "l": "AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+) => ATP + diphthine-[translation elongation factor 2] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.9", "l": "\"spheroidene monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015649", "l": "2-keto-3-deoxygluconate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70904", "l": "(2R)-3-phospho-glyceroyl phosphate + 2-deoxy-alpha-D-ribose 1-phosphate => (2R)-3-phosphoglycerate + 2-deoxy-alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047824", "l": "D-iditol 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32830", "l": "ATP + H2O + methionine(out) <=> ADP + H(+) + methionine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873927", "l": "Release of STAT1 dimer from active receptor unit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66042", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70397", "l": "CoA + H(+) + N-docosanoyl-3-ketodihydrosphingosine => 3-oxosphinganine + docosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17304", "l": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] <=> ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952408", "l": "Polyubiquitinated RUNX3 is degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190256", "l": "FGFR1c binds to FGF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10266", "l": "beta-D-glucose => alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004873", "l": "asialoglycoprotein receptor activity", "d": ["Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034829", "l": "2-hydroxydec-2,4-diene-1,10-dioate hydratase activity", "d": ["Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45882", "l": "4-hydroxy-6-(2-methyldecyl)-pyran-2-one + 2 CO2 + 3 CoA => 3-methylundecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156678", "l": "Activation of Cdc25C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49264", "l": "5-O-[(E)-caffeoyl]-shikimate + H2O = (E)-caffeate + H(+) + shikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75725", "l": "(10S)-hydroxy-(12Z)-octadecenoate => (9Z,12Z)-octadecadienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60095", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) <=> 3-dehydro-4alpha-methylzymosterol + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205244", "l": "Recruitment of CBL to KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16731", "l": "catechol + H(+) + NADPH => (1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72101", "l": "Na(+)(in) + O-acetyl-(R)-carnitine(in) => Na(+)(out) + O-acetyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9842669", "l": "Active LTK recruits GRB2:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482770", "l": "Release of platelet secretory granule components (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102755", "l": "gibberellin-15(closed lactone form),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating) activity", "d": ["Catalysis of the reaction: gibberellin A15 (closed lactone form) + O2 + 2-oxoglutarate = gibberellin A37 (closed lactone form) + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58894", "l": "adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9 => 3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202472", "l": "Translocation of TRAF6 to CBM complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32436", "l": "dihydrocarvone + H(+) + NADPH + O2 => 4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811454", "l": "MAPKs phosphorylate PP2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034569", "l": "monodemethylisoproturon dehydrogenase activity", "d": ["Catalysis of the reaction: monodemethylisoproturon + H2O = hydroxymonodemethylisoproturon + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39663", "l": "a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}, {"i": "EC:1.1.98.4", "l": "\"F420H2:quinone oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160178", "l": "dipeptide uniporter activity", "d": ["Catalysis of the transport of a dipeptide across a membrane; transport is independent of the movement of any other molecular species."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166753", "l": "Conversion of C4 into C4a and C4b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75180", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (R)-axinyssene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851619", "l": "GALNT3 transfers GalNAc to FGF23 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701488", "l": "Active ALK phosphorylates JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67505", "l": "1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77341", "l": "2-oxobutanoate + glycine => (2S)-2-aminobutanoate + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47122", "l": "H2O + N-docosanoylglycine => docosanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56345", "l": "a 7-hydroxyisoflavone + UDP-alpha-D-glucose => a 7-hydroxyisoflavone 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10168", "l": "15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] = biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.2", "l": "\"15,16-dihydrobiliverdin:ferredoxin oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65648", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine = a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59414", "l": "NH4(+) + oxaloacetate => 2-oxosuccinamate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54625", "l": "2-oxoglutarate + O2 + octadecanoyl-CoA => 2-hydroxyoctadecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392187", "l": "Activated P2Y purinoceptor 12 binds G-protein Gi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60362", "l": "dehydro coenzyme F420-0 + FMNH2 => FMN + H(+) + oxidized coenzyme F420-0", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0005385", "l": "zinc ion transmembrane transporter activity", "d": ["Enables the transfer of zinc (Zn) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.-.-", "l": "\"Catalysing the translocation of hydrons\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54567", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O <=> a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912394", "l": "NICD1 in complex with RBPJ (CSL) recruits MAML (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55514", "l": "11-hydroxycucurbitadienol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51971", "l": "(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 <=> (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.472488299857119", "identifiers": [{"i": "GO:0016646", "l": "oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP."], "t": []}, {"i": "EC:1.5.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35462", "l": "cholesterol + NAD(+) <=> cholest-5-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332356", "l": "CAMK2 binds MAP3K7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60290", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250264", "l": "TXNIP binds reduced thioredoxin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41046", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46453", "l": "2 L-leucyl-tRNA(Leu) => cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694506", "l": "Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114684", "l": "Phosphorylation of Syntaxin-4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66289", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15329", "l": "(S)-ureidoglycolate + NAD(+) = H(+) + N-carbamoyl-2-oxoglycine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856951", "l": "PP2A demethylation by PPME1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42567", "l": "uridine(38/39) in tRNA <=> pseudouridine(38/39) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24096", "l": "isoorientin + S-adenosyl-L-methionine = H(+) + isoscoparin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.78", "l": "\"isoorientin 3'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59939", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9655071", "l": "Transcription of DDIT3 (CHOP, GADD153) in response to heme deficiency (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42598", "l": "prostaglandin G2 => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19489", "l": "dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide = 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201717", "l": "CSNK2-mediated phosphorylation of DVL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982617", "l": "CYGB:O2 dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804379", "l": "PRMT5 binds TTC5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39774", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (5Z,8Z,11Z,14Z)-eicosatetraenedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612219", "l": "ERBB4s80 binds to SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46350", "l": "3-hydroxyoctanoyl-CoA => (2E)-octenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50197", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102210", "l": "rhamnogalacturonan endolyase activity", "d": ["Catalysis of the reaction: H2O + a rhamnogalacturonan type I = [rhamnogalacturonan I oligosaccharide]-alpha-L-rhamnose + 4-deoxy-4,5-unsaturated D-galactopyranosyluronate-[rhamnogalacturonan I oligosaccharide]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306953", "l": "GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23140", "l": "beta-nicotinamide D-ribonucleotide + H2O = D-ribose 5-phosphate + H(+) + nicotinamide", "d": [], "t": []}, {"i": "EC:3.2.2.14", "l": "\"NMN nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042878", "l": "D-glucarate transmembrane transporter activity", "d": ["Enables the transfer of D-glucarate, the D-enantiomer of glucarate, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72945", "l": "2 Na(+)(in) + pyruvate(in) => 2 Na(+)(out) + pyruvate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696457", "l": "BDH2 dehydrogenates 3HBA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11086", "l": "CO2 + L-xylulose => 3-dehydro-L-gulonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141026", "l": "Activated protein C cleaves factor Va to factor Vi intermediate form (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2134506", "l": "TGFBR1 is recruited to tight junctions by PARD6A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12156", "l": "2-glutathionyl-2-methylbut-3-en-1-ol + H2O + 2 NAD(+) = 2-glutathionyl-2-methylbut-3-enoate + 3 H(+) + 2 NADH", "d": [], "t": []}, {"i": "EC:1.1.1.398", "l": "\"2-glutathionyl-2-methylbut-3-en-1-ol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75520", "l": "FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2 => (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034875", "l": "NTRK3 phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47431", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) <=> 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.367", "l": "\"ginsenoside 6-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017983", "l": "MECP2 binds CRH gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112514", "l": "JAK activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78841", "l": "[DsrC protein]-trisulfide + 2 a quinol + H(+) => [DsrC protein]-dithiol + 2 a quinone + 2 H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69269", "l": "a (Z)-N-(sulfonatooxy)alkenimidothioate => an alkenyl isothiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977301", "l": "Histidine is decarboxylated to histamine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018792", "l": "bis(4-chlorophenyl)acetate decarboxylase activity", "d": ["Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993447", "l": "HLCS biotinylates 6x(PCCA:PCCB) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019825", "l": "oxygen binding", "d": ["Binding to oxygen (O2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58796", "l": "a flavonol 7-O-beta-D-glucoside + malonyl-CoA = a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23770", "l": "an N-acylsphing-4-enine + CoA + H(+) => a fatty acyl-CoA + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39861", "l": "a triacyl-sn-glycerol + glycerol => a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73705", "l": "UDP-alpha-D-glucuronate(in) + UDP-N-acetyl-alpha-D-glucosamine(out) => UDP-alpha-D-glucuronate(out) + UDP-N-acetyl-alpha-D-glucosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20392", "l": "(2R,3R)-dihydroquercetin + H(+) + NADPH + O2 <=> (2R,3R)-2,3-dihydrogossypetin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59696", "l": "D-cellotetraono-1,5-lactone + H2O = D-cellotetraonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68040", "l": "(R)-lanthionine ketimine + 2 H(+) + NADPH = (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61835", "l": "sitosterol + UDP-alpha-D-glucose <=> H(+) + sitosteryl 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59464", "l": "NADP(+) + octadecan-1-ol = H(+) + NADPH + octadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27668", "l": "CO2 + propanoyl-CoA => (R)-methylmalonyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11827", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O <=> (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48318", "l": "a ganglioside GD1alpha + CMP + H(+) => a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31706", "l": "2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41911", "l": "(3R)-hydroxyhexadecanoyl-[ACP] <=> (2E)-hexadecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78299", "l": "guanosine(34) in tRNA(Tyr) + queuine = guanine + queuosine(34) in tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-532549", "l": "MPI isomerises Fru6P to Man6P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70238", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol <=> an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592240", "l": "Formation of NRF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42315", "l": "H(+) + NADP(+) + 2 reduced [adrenodoxin] <=> NADPH + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21964", "l": "an acylcholine + H2O = a carboxylate + choline + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.8", "l": "\"cholinesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047578", "l": "4-hydroxyglutamate transaminase activity", "d": ["Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034950", "l": "phenylboronic acid monooxygenase activity", "d": ["Catalysis of the reaction: phenylboronic acid + O2 + 2 H+ + 2 e- = phenol + B(OH)3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70997", "l": "SUCLG1/A2 cleaves succinyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22336", "l": "glycine betaine + L-homocysteine = L-methionine + N,N-dimethylglycine", "d": [], "t": []}, {"i": "EC:2.1.1.5", "l": "\"betaine--homocysteine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340124", "l": "CSN polymer binds CaPO4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20264", "l": "3,5,7-trioxododecanoyl-CoA <=> CO2 + CoA + olivetol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50442", "l": "prostaglandin D1 => prostaglandin H1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.891320072305717", "identifiers": [{"i": "GO:0004659", "l": "prenyltransferase activity", "d": ["Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "REACT:R-HSA-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53503", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71081", "l": "cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47576", "l": "a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1c (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71849", "l": "LDH tetramer reduces PYR to LACT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12820", "l": "2,3-dihydrobiochanin A + NADP(+) <=> biochanin A + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0004357", "l": "glutamate-cysteine ligase activity", "d": ["Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.156", "l": "\"oligosaccharide reducing-end xylanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641134", "l": "SMURF2 binds AXIN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35064", "l": "H2O + pyrazinamide => NH4(+) + pyrazine-2-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2514867", "l": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73217", "l": "sulfate(in) + thiosulfate(out) => sulfate(out) + thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57268", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP = GMP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396009", "l": "STING binds c-di-GMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12294", "l": "AMP + diphosphate + H(+) + L-seryl-tRNA(Ser) => ATP + L-serine + tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19290", "l": "H2O + sucrose 6(F)-phosphate => phosphate + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44818", "l": "2-demethylmenaquinol-12 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33337", "l": "1,2-dioctadecanoyl-sn-glycerol + phosphate => 1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174456", "l": "Joining of adjacent Okazaki fragments of the C-strand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21457", "l": "(S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] => (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189406", "l": "4 PBGs bind to form HMB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57537", "l": "a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + a ribonucleoside 5'-triphosphate => a 5'-end NTP-ribonucleotide-RNA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004501", "l": "ecdysone 20-monooxygenase activity", "d": ["Catalysis of the reaction: AH(2) + Ecdysone + O2 = 20-hydroxyecdysone + A + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649655", "l": "NEIL1 recognizes and binds DHU-dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112342", "l": "Inactivation of MAP2K1 by CDK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68108", "l": "L-glucitol + NAD(+) = H(+) + keto-L-fructose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31489", "l": "H(+) + soyasaponin III + UDP => soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160151", "l": "tRNA pseudouridine(32) synthase activity", "d": ["Catalysis of the reaction: uridine(32) in tRNA = pseudouridine(32) in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602466", "l": "Activation of MT-MMPs by FURIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6791227", "l": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352371", "l": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051022", "l": "Rho GDP-dissociation inhibitor binding", "d": ["Binding to a Rho GDP-dissociation inhibitor protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40533", "l": "H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56406", "l": "(3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631065", "l": "Substrate translocates into late endosomal lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9859148", "l": "BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57624", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67197", "l": "H2O + N-acetylserotonin => acetate + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20374", "l": "ATP + CoA + propanoate => AMP + diphosphate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37100", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + H2O => a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) + N(7)-methyl-GMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416510", "l": "GRK5 sequesters activated Gq (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44725", "l": "2,3-saturated fatty aldehyde + NADP(+) => (2E)-fatty aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75031", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate = 2-(9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426154", "l": "SREBP1A,2 binds the LSS promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.89", "l": "\"arabinogalactan endo-beta-1,4-galactanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11318", "l": "a nitrile + H2O => an aliphatic aldoxime", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19223", "l": "formate + H(+) + methanol => 2 formaldehyde + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939963", "l": "Activated AKT phosphorylates RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67478", "l": "diphosphate + prekainate => dimethylallyl diphosphate + L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59320", "l": "D-cellobiono-1,5-lactone + H2O = 4-O-beta-D-glucopyranosyl-D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833066", "l": "SOX2 binds the ZEB2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52028", "l": "a jasmonyl-L-amino acid + H2O = a jasmonate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67384", "l": "5beta-cholestane-3alpha,7alpha-diol + O2 + reduced [NADPH--hemoprotein reductase] = 5beta-cholestane-3alpha,7alpha,25-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72466", "l": "L-threonyl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14353", "l": "3-dehydro-L-gulonate 6-phosphate + H(+) = CO2 + L-xylulose 5-phosphate", "d": [], "t": []}, {"i": "EC:4.1.1.85", "l": "\"3-dehydro-L-gulonate-6-phosphate decarboxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.74", "l": "\"1,4-dihydroxy-2-naphthoate polyprenyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16298", "l": "5alpha-androstane-3beta,17beta-diol + NADP(+) => 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71545", "l": "5-phosphomethyl-dUMP in DNA + ADP + H(+) => 5-hydroxymethyl-dUMP in DNA + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78177", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an all-trans-retinyl ester => a 1,2-diacyl-sn-glycero-3-phosphocholine + all-trans-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60024", "l": "(R,R)-chrysanthemyl diphosphate + H2O = (R,R)-chrysanthemol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201639", "l": "Caspase-mediated cleavage of GAS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55834", "l": "6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cortisone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034618", "l": "arginine binding", "d": ["Binding to 2-amino-5-(carbamimidamido)pentanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41449", "l": "2-oxoglutarate + L-isoleucine + O2 => (4S)-4-hydroxy-L-isoleucine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008692", "l": "IL37(?-218) binds SMAD3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31691", "l": "(9Z,12Z)-octadecadienoate + O2 = (9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390641", "l": "ADRA1A,B,D bind ADR,NAd (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56239", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58549", "l": "2 L-ascorbate + N-(9Z,12Z,15Z)-octadecatrienoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23728", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2", "d": [], "t": []}, {"i": "EC:1.14.99.1", "l": "\"prostaglandin-endoperoxide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39393", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+) => (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009227", "l": "IL20 binds to IL22RA1:JAK1:IL20RB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034909", "l": "6-hydroxypseudooxynicotine dehydrogenase activity", "d": ["Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 e- + methylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48926", "l": "an N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP + H(+) => a ganglioside GM4 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65415", "l": "dAMP(in) + NAD(+)(out) <=> dAMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10342", "l": "(-)-vetispiradiene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693243", "l": "RHOD translocates to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71031", "l": "L-cysteine(in) + L-phenylalanine(out) = L-cysteine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73233", "l": "2-chloro-6-hydroxy-1,4-benzoquinone + 2 chloride + FAD + 3 H(+) => 2,4,6-trichlorophenol + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10959", "l": "(E)-cinnamate + H(+) + NADPH + O2 <=> H2O + NADP(+) + trans-2-coumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48577", "l": "4-chlorocatechol + O2 => 3-chloro-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11863", "l": "ATP + L-histidyl-[protein] <=> ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683801", "l": "CHEK2 phosphorylates BRCA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69299", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate <=> 3-hydroxypent-4-ene nitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.47", "l": "\"horrilysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72448", "l": "a dicarboxylate(in) + estrone 3-sulfate(out) => a dicarboxylate(out) + estrone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21817", "l": "a D-alpha-amino acid + H2O + O2 => a 2-oxocarboxylate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54825", "l": "H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein] => alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036131", "l": "prostaglandin D2 11-ketoreductase activity", "d": ["Catalysis of the reaction: prostaglandin D2 + H+ + NADPH = 11-epi-prostaglandin F2alpha + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27965", "l": "myo-inositol + pyrroloquinoline quinone <=> H(+) + pyrroloquinoline quinol + scyllo-inosose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44576", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) = 2-all-trans-nonaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12745", "l": "a 1,4-lactone + H2O = a 4-hydroxyacid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019140", "l": "inositol 3-kinase activity", "d": ["Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15467", "l": "ADP + H(+) + sphinganine 1-phosphate => ATP + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40420", "l": "H2O + phytanoyl-CoA => 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031177", "l": "phosphopantetheine binding", "d": ["Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23865", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate => 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43057", "l": "5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH => 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090587", "l": "protein-phosphocysteine-glucosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucosamine (out) = protein cysteine + glucosamine-6-phosphate (in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875568", "l": "RAPGEF1 activates RAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76476", "l": "hexadecan-1-ol + O2 => H2O2 + hexadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001784", "l": "phosphotyrosine residue binding", "d": ["Binding to a phosphorylated tyrosine residue within a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28712", "l": "H(+)(in) + N-(4-aminobenzoyl)-L-glutamate(in) => H(+)(out) + N-(4-aminobenzoyl)-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.61064910827011", "identifiers": [{"i": "GO:0003899", "l": "DNA-directed 5'-3' RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864029", "l": "PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67915", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O <=> 1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1013020", "l": "Activation of GIRK/Kir3 Channels (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42814", "l": "cholesteryl octadecanoate + CoA => cholesterol + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102080", "l": "phenylacetyl-coenzyme A:glycine N-acyltransferase activity", "d": ["Catalysis of the reaction: phenylacetyl-CoA + glycine = H+ + phenylacetylglycine + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047113", "l": "aldehyde dehydrogenase (quinone) activity", "d": ["Catalysis of the reaction: a quinone + an aldehyde + H2O = a carboxylate + a quinol + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53746", "l": "glycine + H(+) + tRNA(Ala) => glycyl-tRNA(Ala) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39208", "l": "3-oxohexacosanoyl-CoA + H(+) + NADPH => (3R)-hydroxyhexacosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655826", "l": "Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10163", "l": "L-iditol + NAD(+) <=> H(+) + keto-L-sorbose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.70", "l": "\"sortase A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70762", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine <=> 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24044", "l": "3,4-dihydroxybenzoate + O2 = 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.8", "l": "\"protocatechuate 4,5-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26141", "l": "2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + H2O => 5-amino-6-(5-phospho-D-ribitylamino)uracil + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9854368", "l": "ROS,RNS oxidize ACO2:4Fe-4S (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693282", "l": "RHOF GAPs stimulate RHOF GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617867", "l": "HOXB4 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36861", "l": "3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA => (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53772", "l": "chenodeoxycholate + lithocholoyl-CoA = chenodeoxycholoyl-CoA + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174195", "l": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372852", "l": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63532", "l": "angiotensin I + H2O = angiotensin-(1-9) + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76907", "l": "(1S)-2-methyl-cyclohexylamine + H2O + NADP(+) = 2-methylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73198", "l": "malonate(in) + sulfate(out) <=> malonate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37992", "l": "delta-tocopherol + S-adenosyl-L-methionine => beta-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.2.4", "l": "\"fatty-acid peroxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483081", "l": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004594", "l": "pantothenate kinase activity", "d": ["Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0016664", "l": "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein."], "t": []}, {"i": "EC:1.7.7.-", "l": "\"With an iron-sulfur protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35242", "l": "tetracycline(in) <=> tetracycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12076", "l": "an aromatic primary alcohol + NAD(+) = an aromatic aldehyde + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.90", "l": "\"aryl-alcohol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17074", "l": "acetyl-CoA + cortisol => CoA + cortisol 21-acetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031518", "l": "NR1H2,3 binds the APOC1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41498", "l": "1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52773", "l": "7,8-dihydroneopterin 3'-triphosphate => 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0140658", "l": "ATP-dependent chromatin remodeler activity", "d": ["An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635842", "l": "ULK3 phosphorylates GLI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75509", "l": "n H(+)(in) + taurocholate(in) => n H(+)(out) + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.26", "l": "\"sterol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52321", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryptamine => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700656", "l": "alectinib resistant ALK mutants don't bind alectinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65404", "l": "butan-1-ol + hexanoyl-CoA = butyl hexanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48814", "l": "(5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174444", "l": "Formation of C-strand Okazaki fragments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14246", "l": "ATP + H2O => AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13035", "l": "keto-D-tagatose 6-phosphate => aldehydo-D-galactose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50112", "l": "octadecanoyl-CoA + taurine = CoA + H(+) + N-octadecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005142", "l": "interleukin-11 receptor binding", "d": ["Binding to an interleukin-11 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9853385", "l": "PPP1CC dephosphorylates PLK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25154", "l": "3-phenylpyruvate + L-glutamate => 2-oxoglutarate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070226", "l": "sulfur:ferric ion oxidoreductase activity", "d": ["Catalysis of the reaction: a perthiol + 4 Fe3+ + 3 H2O = sulfite + a thiol + 4 Fe2+ + 8 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69008", "l": "2 H(+) + L-aspartate + 3 NADPH + 3 O2 = 2-nitrobutanedioate + 4 H2O + 3 NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.248", "l": "\"L-aspartate N-monooxygenase (nitrosuccinate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661745", "l": "An unknown BILR reduces BIL to D-UBGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018572", "l": "EGFR phosphorylates NOTCH3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44877", "l": "a 1,3-diacylglycerol + H2O => a 3-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36806", "l": "2-hydroxy-2,3-dihydrogenistein <=> genistein + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046966", "l": "nuclear thyroid hormone receptor binding", "d": ["Binding to a nuclear thyroid hormone receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1471354", "l": "HNP1-3 bind gp120 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48216", "l": "H(+) + hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033942", "l": "4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity", "d": ["Catalysis of the hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855201", "l": "I(1,3,4,6)P4 transports from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-844612", "l": "PYCARD recruits procaspase-1 via CARD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73697", "l": "dADP(in) + H(+)(in) + phosphate(out) => dADP(out) + H(+)(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237119", "l": "Acireductone is oxidized to MOB (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14586", "l": "gibberellin A12 + 5 H(+) + 3 O2 + 4 reduced [2Fe-2S]-[ferredoxin] => CO2 + gibberellin A9 + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27432", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 1,2-diacyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9842665", "l": "Active LTK binds GRB2:TNK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71197", "l": "H(+)(in) + Zn(2+)(in) => H(+)(out) + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44660", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669012", "l": "EDA binds EDAR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11564", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + phosphate = alpha-D-glucose 1-phosphate + D-gluconate", "d": [], "t": []}, {"i": "EC:2.4.1.321", "l": "\"cellobionic acid phosphorylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59702", "l": "D-cellopentaonate + H(+) => D-cellopentaono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54286", "l": "H(+) + N-octadecanoylsphing-4-enine + phosphocholine => H2O + N-(octadecanoyl)-sphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29604", "l": "benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] => 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22349", "l": "4-aminoimidazole + H(+) + H2O => imidazol-4-one + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649686", "l": "NEIL2 recognizes and binds 5-OHU-dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29328", "l": "(S)-malate(in) + succinate(out) => (S)-malate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51143", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + 2 O2 <=> (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9857365", "l": "MITF-M-dependent BIRC7 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111962", "l": "PDE4A,C,D hydrolyse cAMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610723", "l": "GLI proteins bind SUFU (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028821", "l": "Dimerization of Phospho IRF3 or phospho IRF7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951951", "l": "RUNX3 binds EP300 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79108", "l": "glycocholate + L-histidine => glycine + L-histidocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9851407", "l": "FAM83B, (FAM83A, FAM83D) bind EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062070", "l": "SAGA complex binding", "d": ["Binding to a SAGA complex."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701562", "l": "CD274 gene expression downstream of ALK signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50347", "l": "3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH <=> 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851679", "l": "GPR183 binds 7alpha,25-dihydroxycholesterol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15656", "l": "ATP + beta-D-fructose 6-phosphate <=> ADP + beta-D-fructose 2,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19049", "l": "(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.81", "l": "\"hydroxylysine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26217", "l": "abieta-7,13-diene + O2 + reduced [NADPH--hemoprotein reductase] = abieta-7,13-dien-18-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.144", "l": "\"abieta-7,13-diene hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71776", "l": "acetoacetate(out) + H(+)(out) => acetoacetate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39377", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28248", "l": "(R)-4-phosphopantoate + ADP + H(+) => (R)-pantoate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77905", "l": "2 Fe(II)-[cytochrome c] + fumarate + 2 H(+) => 2 Fe(III)-[cytochrome c] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69183", "l": "ADP + thiamine diphosphate <=> AMP + thiamine triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14865", "l": "S-adenosyl-L-methionine + tyramine = H(+) + N-methyltyramine + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.27", "l": "\"tyramine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73389", "l": "H(+)(out) + malonate(in) + phosphate(out) => H(+)(in) + malonate(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37714", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008663", "l": "2',3'-cyclic-nucleotide 2'-phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75849", "l": "SLC25A1 exchanges CIT and MAL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49021", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one => 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.24", "l": "\"diphosphoinositol-pentakisphosphate 1-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28972", "l": "H(+)(in) + shikimate(in) => H(+)(out) + shikimate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78271", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-delta-cadinol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.212", "l": "\"(+)-delta-cadinol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879909", "l": "Activation of STAT5a/b by JAK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41318", "l": "1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56420", "l": "apo-[D-alanyl-carrier protein] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[D-alanyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71363", "l": "17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) = 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350598", "l": "Arginine<=>Agmatine+CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030293", "l": "transmembrane receptor protein tyrosine kinase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38694", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5082391", "l": "Trimerization of HSF1 in the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23736", "l": "5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)", "d": [], "t": []}, {"i": "EC:3.5.2.17", "l": "\"hydroxyisourate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21421", "l": "NADP(+) + prostaglandin I2 => 15-dehydro-prostaglandin I2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38803", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44661", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + sphing-4-enine => 1-O-alkyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20967", "l": "2-oxoglutarate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9688456", "l": "MLKL binds FLOT1, FLOT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021520", "l": "NOTCH3 binds WWP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193964", "l": "CYP21A2 21-hydroxylates PROG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73435", "l": "apigenin 4',7-dimethyl ether + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + ladanein + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.2.-", "l": "\"With dinitrogen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450348", "l": "Activated human JNKs migrate to nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047761", "l": "butyrate kinase activity", "d": ["Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24635", "l": "2 H2O + 3 NADP(+) + NH4(+) <=> 5 H(+) + 3 NADPH + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20812", "l": "(3S)-citryl-CoA = acetyl-CoA + oxaloacetate", "d": [], "t": []}, {"i": "EC:4.1.3.34", "l": "\"citryl-CoA lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71101", "l": "androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in) => androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5618328", "l": "ATAT acetylates microtubules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029476", "l": "Role of myosins in phagosome formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49637", "l": "H2O + methylglyoxal + O2 => H(+) + H2O2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23242", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate => (6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005460", "l": "UDP-glucose transmembrane transporter activity", "d": ["Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77352", "l": "2-oxobutanoate + N(omega),N(omega)-dimethyl-L-arginine => (2S)-2-aminobutanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008774", "l": "acetaldehyde dehydrogenase (acetylating) activity", "d": ["Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034849", "l": "2-naphthoate CoA-transferase activity", "d": ["Catalysis of the reaction: 2-naphthoyl-CoA + OH- = 2-naphthoate + CoASH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170070", "l": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72317", "l": "glutathione(out) + leukotriene C4(in) => glutathione(in) + leukotriene C4(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21718", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + (S)-4-hydroxymandelate + H2O => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + (S)-mandelate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23082", "l": "2-dehydro-3-deoxy-L-rhamnonate + H2O => L-rhamnonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17876", "l": "an R-cob(III)alamin(out) + ATP + H2O <=> ADP + an R-cob(III)alamin(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73765", "l": "2 ADP + cyclo(L-tryptophyl-L-alanyl) + 2 H(+) + 2 phosphate => 2 ATP + L-alanine + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48121", "l": "a ganglioside GD3 + H2O => a ganglioside GM3 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950504", "l": "IL27 binds CRLF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59835", "l": "ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] <=> ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.18", "l": "\"pancreatic ribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400071", "l": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23663", "l": "4-imidazolone-5-propanoate + H2O <=> N-formimidoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196929", "l": "FLAD1 phosphorylates FMN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50164", "l": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000250", "l": "lanosterol synthase activity", "d": ["Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823932", "l": "Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32177", "l": "alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + GDP + H(+) => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67313", "l": "(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one => myceliothermophin E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28383", "l": "H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine => D-glucose 6-phosphate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38814", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31464", "l": "crocetin + UDP-alpha-D-glucose => beta-D-glucosyl crocetin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71700", "l": "H(+)(out) + L-phenylalanyl-L-leucine(out) => H(+)(in) + L-phenylalanyl-L-leucine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33089", "l": "1,4-dihydroxy-6-naphthoate + dihydroxyacetone => cyclic dehypoxanthinylfutalosinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51332", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = 11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62147", "l": "dGMP + dGTP <=> 2 dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692755", "l": "CDK1 phosphorylates MAPK6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21372", "l": "H(+) + H2O + urethane = CO2 + ethanol + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.75", "l": "\"urethanase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705010", "l": "SARS-CoV-2 nsp6 binds TBK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018817", "l": "RHOT1 GEFs activate RHOT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888589", "l": "Release of GABA at the synapse (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73757", "l": "Binding of RRN3 to RNA Polymerase I (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28125", "l": "ATP + di-trans,octa-cis-undecaprenol <=> ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50751", "l": "H2O + juglone <=> naphthalene-1,2,4,8-tetrol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75962", "l": "(S)-scoulerine + 2-oxoglutarate + O2 <=> (S)-3-O-demethylscoulerine + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25249", "l": "H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40423", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63303", "l": "N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784861", "l": "HSPG binds LPL dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878603", "l": "SSC5D binds ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15502", "l": "2 L-glutamate + NADP(+) => 2-oxoglutarate + H(+) + L-glutamine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67014", "l": "a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate => a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1650808", "l": "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686704", "l": "Activated ATM phosphorylates DCLRE1C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-451309", "l": "Edited Kainate Receptor binds glutamate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44508", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.5.-", "l": "\"Methylenetransferases\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984964", "l": "IL12A gene transcription and translation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60457", "l": "ATP + UTP => 3',3'-cUAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672973", "l": "MAP2Ks phosphorylate MAPKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65008", "l": "ATP + decanoate + H(+) = decanoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36177", "l": "1-O-alkyl-sn-glycero-3-phosphate + NADP(+) => 1-O-alkylglycerone 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034005", "l": "germacrene-A synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76600", "l": "(9Z,12Z)-octadecadienoate + H2O => (12Z)-10-hydroxyoctadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015057", "l": "thrombin-activated receptor activity", "d": ["A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71729", "l": "citrate(in) + fumarate(out) => citrate(out) + fumarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28190", "l": "2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707690", "l": "BACH1 binds MAFK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373748", "l": "SEMA4D interacts with CD72 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47429", "l": "(3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+) => 3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.11.1.20", "l": "\"prostamide/prostaglandin F2alpha synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48615", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] <=> [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25337", "l": "H2O + L-cysteinyl-tRNA(Cys) <=> H(+) + L-cysteine + tRNA(Cys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016162", "l": "cellulose 1,4-beta-cellobiosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034867", "l": "2,4,4-trimethylpent-2-enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethylpent-2-enoyl-CoA + H2O = 2,4,4-trimethyl-3-hydroxypentanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41063", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428123", "l": "KDSR reduces 3-ketosphingoid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.171", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043871", "l": "delta1-piperideine-6-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: delta1-piperideine-6-carboxylate + NAD+ + 2 H2O = 2-aminoadipate + NADH + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975594", "l": "PLB1 hydrolyses RPALM to atROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45887", "l": "12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62624", "l": "[glutaredoxin]-dithiol + a hydroperoxide = [glutaredoxin]-disulfide + an alcohol + H2O", "d": [], "t": []}, {"i": "EC:1.11.1.25", "l": "\"glutaredoxin-dependent peroxiredoxin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050114", "l": "myo-inosose-2 dehydratase activity", "d": ["Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102147", "l": "3'-O-methyltricetin O methyl transferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3'-O-methyltricetin = H+ + S-adenosyl-L-homocysteine + 3',5'-di-O-methyltricetin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10840", "l": "H2O + O-phospho-L-homoserine = L-threonine + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.1", "l": "\"threonine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38848", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848618", "l": "Activation of RAC1 by the PXN:CRK complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12178", "l": "H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine => phenylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-996727", "l": "REST recruits the BHC complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102501", "l": "D-fructuronate reductase activity", "d": ["Catalysis of the reaction: D-mannonate + NADP = NADPH + H+ + D-fructuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28780", "l": "4-hydroxy-L-threonine => glycine + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15135", "l": "2-oxoglutarate + H(+) + NADH + NH4(+) => H2O + L-glutamate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047125", "l": "delta1-piperideine-2-carboxylate reductase activity", "d": ["Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta1-piperideine-2-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694662", "l": "Protein 3a forms a homotetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0043177", "l": "organic acid binding", "d": ["Binding to an organic acid, any acidic compound containing carbon in covalent linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20102", "l": "a long-chain fatty acid + ATP + L-cysteinyl-[protein] => AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46189", "l": "an aliphatic nitrile + 2 H2O => a carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66162", "l": "CoA + H(+) + N-hexanoyltyramine => hexanoyl-CoA + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21751", "l": "(S)-lactaldehyde + NADP(+) <=> H(+) + methylglyoxal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19518", "l": "H2O + N,N-dimethylformamide => dimethylamine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102500", "l": "beta-maltose 4-alpha-glucanotransferase activity", "d": ["Catalysis of the reaction: beta-D-glucose + a plant soluble heteroglycan = a plant soluble heteroglycan + maltose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429694", "l": "CERT1-2 complex dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55759", "l": "2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 <=> a 2-hydroxyornithine lipid + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9762246", "l": "ANGPTL4 binds CDH11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68691", "l": "3'-phosphoadenylyl sulfate + 3beta-androst-5-en-17-one 3-O-(beta-D-glucuronate) <=> 3beta-androst-5-en-17-one 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56942", "l": "2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate => S-methyl-5-thio-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22054", "l": "AH2 + H(+) + hydroxylamine => A + H2O + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9015111", "l": "Factor Xa inhibitors binds Xa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59538", "l": "(2R)-ethylmalonyl-CoA + ADP + H(+) + phosphate => ATP + butanoyl-CoA + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68240", "l": "L-methionine(in) + Na(+)(in) = L-methionine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40057", "l": "2,3-dioctanoyl-sn-glycerol + H(+) + octanoate => 1,2,3-trioctanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809764", "l": "SBF1 binds MTMR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212269", "l": "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003908", "l": "methylated-DNA-[protein]-cysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39607", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH = (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37184", "l": "(9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate => 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623524", "l": "The exocyst complex binds to RAB3IP in the ciliary targeting complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004447", "l": "iodide peroxidase activity", "d": ["Catalysis of the reaction: iodide + H2O2 = iodine + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9621179", "l": "Cinaciguat binds sGC:NO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874200", "l": "CREB3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47994", "l": "H(+)(out) + NADH + NADP(+) => H(+)(in) + NAD(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0048408", "l": "epidermal growth factor binding", "d": ["Binding to epidermal growth factor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013974", "l": "Auto-ubiquitination of TRAF3 within activated TLR3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793988", "l": "LUBAC ubiquitinates CFLAR at K351, K353 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52050", "l": "(9Z)-octadecenoate + 9-hydroxy-octadecanoate + H(+) => 9-(9Z-octadecenoyloxy)-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381644", "l": "ER calcium channels open in response to activated PKA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31703", "l": "2 H(+) + O2 + pentalenene + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70503", "l": "H2O + isopentenyl diphosphate = H(+) + isopentenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78721", "l": "3-dehydro-D-glucose + D-glucose => 3-dehydro-alpha,alpha-trehalose + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166038", "l": "GPI-bound CD14 binds LPS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848414", "l": "Activated PTK6 binds CDKN1B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645442", "l": "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0018549", "l": "methanethiol oxidase activity", "d": ["Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696457", "l": "BDH2 dehydrogenates 3HBA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39347", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH = (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664991", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75735", "l": "10-oxo-(12Z)-octadecenoate = 10-oxo-(11E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77542", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA <=> 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41223", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63819", "l": "ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine <=> AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43847", "l": "(3beta)-hydroxy-cholest-5-en-26-al + NADPH + O2 <=> (3beta)-hydroxy-cholest-5-en-26-oate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429449", "l": "Syk activation leads to SLP-76 activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17338", "l": "catechol + O2 => (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68679", "l": "3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate) <=> adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74577", "l": "N(alpha)-acetyl-L-methionine + N-terminal L-glutamyl-[protein] => H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35169", "l": "minocycline(out) => minocycline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38909", "l": "(R)-laudanine + H(+) + S-adenosyl-L-homocysteine => (R)-reticuline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9845587", "l": "ST8SIA5 transfers Neu5Ac to gangliosides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27538", "l": "ethanol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939082", "l": "RUNX1 binds the CR1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72772", "l": "7-methylmellein + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 7-carboxymellein + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10673", "l": "cyclobutadithymidine in DNA => a thymidine dimer in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9613497", "l": "Unwinding DNA for the nascent transcript (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162590", "l": "Import of PIC to the Host Nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41098", "l": "H2O + sphing-4-enine-phosphocholine <=> H(+) + phosphocholine + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32351", "l": "3 S-adenosyl-L-methionine + tricetin = 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.169", "l": "\"tricetin 3',4',5'-O-trimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23060", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP = a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.1.3.1", "l": "\"olefin beta-lactone synthetase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784319", "l": "JAK1,TYK2 phosphorylate JAK1,TYK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005519", "l": "cytoskeletal regulatory protein binding", "d": ["Binding to a protein involved in modulating the reorganization of the cytoskeleton."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66757", "l": "ATP + domoate(in) + H2O => ADP + domoate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61410", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine => ATP + N(6)-(D-erythrulosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76872", "l": "(S)-1-phenylethylamine + H2O + NAD(+) => acetophenone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14503", "l": "2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+) => H2O + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444047", "l": "Receptor FFAR3 binds carboxylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23618", "l": "alpha-santonin + H(+) + NADPH => 1,2-dihydro-alpha-santonin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801675", "l": "PLK2 phosphorylates NPM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53988", "l": "H2O + O-phospho-L-threonyl-[myosin light chain] = L-threonyl-[myosin light chain] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61735", "l": "steviol + UDP-alpha-D-glucose <=> H(+) + steviolmonoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56975", "l": "(R)-3-hydroxy-2-methylpropanoate + NAD(+) <=> (R)-2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24813", "l": "2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65546", "l": "an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-D-Glc => a ganglioside GM1 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72214", "l": "(+)-isoborneol + NAD(+) <=> (1S,4S)-camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9856718", "l": "HPDL dioxygenates HPPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9866217", "l": "HCCS inserts heme into cytochrome c (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26500", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76991", "l": "H(+) + NAD(+) + reduced 2[4Fe-4S]-[ferredoxin] = NADH + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45809", "l": "galactarate => (2S,3R)-dihydroxy-5-oxohexanedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.63", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033728", "l": "divinyl chlorophyllide a 8-vinyl-reductase activity", "d": ["Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33579", "l": "NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate = H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate", "d": [], "t": []}, {"i": "EC:1.1.1.335", "l": "\"UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19359", "l": "formaldehyde + H2O + N-methyl-L-proline + NADP(+) => H(+) + L-proline betaine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044587", "l": "cellopentaose binding", "d": ["Binding to a cellopentaose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912363", "l": "PRDM9 binds recombination hotspot motifs in DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54087", "l": "7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine <=> archaeosine(15) in tRNA + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1362261", "l": "p130 (RBL2) associates with MuvB to form DREAM complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985153", "l": "OASL binds DDX58 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69768", "l": "(E)-non-2-enal + H2O + NAD(+) => (E)-non-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937419", "l": "CBR3 reduces DOX to DOXOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678998", "l": "Endosomal TLRs pass through the Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48070", "l": "a ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate => a ganglioside GM2 (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37530", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625123", "l": "Defective SLC20A2 does not cotransport Pi, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13306", "l": "(E)-sinapate + UDP-alpha-D-glucose => 1-O-(trans-sinapoyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40433", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.135", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36919", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205799", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57182", "l": "N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] => L-lysyl-[protein] + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58475", "l": "2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 <=> CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25953", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde => 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080109", "l": "indole-3-acetonitrile nitrile hydratase activity", "d": ["Catalysis of the reaction: indole-3-acetonitrile + H2O = indole-3-acetamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65271", "l": "3-hydroxypentacecilide A + H(+) + NADPH + O2 <=> chrodrimanin F + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49599", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose <=> H(+) + N-acyl-D-galactosylsphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213246", "l": "Disassociation of CLIP from MHC II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844251", "l": "GP1BA variant binds to VWF multimer:collagen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34134", "l": "neryl diphosphate + olivetolate <=> cannabinerolate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49921", "l": "(R)-carnitine(out) + O-octanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-octanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176417", "l": "SMAD7:NEDD4L complex translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46955", "l": "2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75601", "l": "ectocarpin A + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710354", "l": "GSDME (1-270) binds cardiolipin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14607", "l": "alpha,alpha-trehalose 6-phosphate + GDP + H(+) => D-glucose 6-phosphate + GDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.185", "l": "\"flavanone 7-O-beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70445", "l": "a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653886", "l": "B4GALT1 binds LALBA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391941", "l": "BLT receptors can bind LTB4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4717521", "l": "PIAS1 SUMOylates NR2C1 (TR2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60976", "l": "(E)-4-hydroxynon-2-en-1-ol + NAD(+) = (E)-4-hydroxynon-2-enal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54480", "l": "1-octadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46187", "l": "3-methylbutanoate + ATP + CoA <=> 3-methylbutanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806610", "l": "Keratin filament formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60847", "l": "a 5'-end diphospho-guanosine in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17987", "l": "4-(trimethylamino)butanoate + 2 H(+) + NADH => 4-(trimethylamino)butanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47473", "l": "(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH => (3E)-tetradecenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57058", "l": "D-apionolactone + H(+) + NADH => D-apiofuranose + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102941", "l": "3,5-dihydroxyanisole O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,5-dihydroxyanisole + S-adenosyl-L-methionine = H+ + 3,5-dimethoxyphenol + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003828", "l": "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity", "d": ["Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9817575", "l": "ERO1B oxidizes P4HB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354173", "l": "Activation of Rap1 by cytosolic GEFs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15328", "l": "an acyl-CoA + sn-glycerol 3-phosphate <=> a 1-acyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030987", "l": "high molecular weight kininogen receptor binding", "d": ["Binding to a high molecular weight kininogen receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83723", "l": "Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830706", "l": "IKKε (IKBKE) is phosphorylated within the activated TLR3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32142", "l": "ATP + CoA + malonate <=> AMP + diphosphate + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389532", "l": "PP2A binds CTLA4 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32429", "l": "(S)-carvone + AH2 => (1R,4S)-isodihydrocarvone + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29203", "l": "dimethyl sulfoxide + menaquinol-8 = dimethyl sulfide + H2O + menaquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862380", "l": "HSD17B13 binds lipid droplets (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952044", "l": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23292", "l": "ATP + L-lombricine = ADP + H(+) + N-phospho-L-lombricine", "d": [], "t": []}, {"i": "EC:2.7.3.5", "l": "\"lombricine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578783", "l": "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110360", "l": "Recruitment of POLB to the AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799545", "l": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43192", "l": "cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9707856", "l": "PGRMC2:Hemes dissociates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445069", "l": "L1-EGFR trans-heterodimerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9825782", "l": "p-S207 KARS1 dimer binds MITF-M:HINT1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202724", "l": "P-selectin binds P-selectin ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73786", "l": "dimethylallyl diphosphate + tardioxopiperazine A <=> diphosphate + echinulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216283", "l": "RDX binds to and ubiquitinates CI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264997", "l": "P4HB mediates disulfide bond formation in Proinsulin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009000", "l": "selenocysteine lyase activity", "d": ["Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604690", "l": "Activation of MMP9 intermediate form by MMPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9793451", "l": "MLKL binds ITCH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9861745", "l": "Mitochondrial H2O2 decarboxylates PYR to acetate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18621", "l": "2-oxoglutarate + a (2S)-flavan-4-one + O2 = a (2R,3R)-dihydroflavonol + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.9", "l": "\"flavanone 3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.154", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15503", "l": "2-oxoglutarate + H(+) + L-glutamine + NADPH => 2 L-glutamate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13860", "l": "a dolichyl beta-D-glucosyl phosphate + H2O <=> a dolichyl phosphate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24548", "l": "an N(6)-acyl-L-lysine + H2O = a carboxylate + L-lysine", "d": [], "t": []}, {"i": "EC:3.5.1.17", "l": "\"acyl-lysine deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052639", "l": "salicylic acid glucosyltransferase (ester-forming) activity", "d": ["Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46840", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65749", "l": "2-oxoglutarate + dodecyl sulfate + O2 => CO2 + dodecanal + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981832", "l": "NMUR2 binds neuromedin-S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19724", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA <=> (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23297", "l": "aceneuramate => N-acetyl-D-mannosamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56032", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15842", "l": "D-glucose 6-phosphate + NADP(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984606", "l": "Kinesin-5 is a homotetramer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211948", "l": "CYP3A4 can N-demethylate loperamide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39389", "l": "(2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59941", "l": "2-methyloctadecanoyl-CoA + H2O => 2-methyloctadecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61285", "l": "H2O + L-cystine + O2 => (2R)-2-amino-2-carboxylatoethyl-disulfanyl-oxopropanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008999", "l": "peptide-alanine-alpha-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-peptide = CoA + H+ + N-terminal N-alpha-acetyl-L-alanyl-peptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20996", "l": "(2Z,4E)-2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.99.5", "l": "\"2-aminomuconate deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58362", "l": "(5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57924", "l": "H2O + mutildienyl diphosphate = diphosphate + premutilin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79131", "l": "cholate + L-alanine = H2O + L-alanocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.-.-", "l": "\"Acting on ester bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67015", "l": "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) <=> a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749253", "l": "Formation of MCM2-7 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32800", "l": "urea(in) => urea(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70028", "l": "N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyl,N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004155", "l": "6,7-dihydropteridine reductase activity", "d": ["Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019115", "l": "benzaldehyde dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25016", "l": "H(+) + N,N-dihydroxy-L-tryptophan <=> (E)-(indol-3-yl)acetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67044", "l": "A + asnovolin H = AH2 + chermesin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39238", "l": "(3R)-hydroxytriacontanoyl-CoA <=> (2E)-triacontenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73032", "l": "Cd(2+)(out) + H(+)(out) => Cd(2+)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392870", "l": "Gs activation by prostacyclin receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53132", "l": "A + a 3-oxo-Delta(4)-steroid = a 3-oxo-Delta(1,4)-steroid + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39577", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + NADP(+) => 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41332", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4411373", "l": "NLK translocates to nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54245", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50486", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047753", "l": "choline-sulfatase activity", "d": ["Catalysis of the reaction: choline sulfate + H2O = choline + H+ + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5662662", "l": "Tyrosinase oxidises tyrosine to dopaquinone (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42146", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18768", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.2.3", "l": "\"trimethylamine-N-oxide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48204", "l": "H(+) + oxidized [electron-transfer flavoprotein] + pentadecanoyl-CoA = (2E)-pentadecenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36158", "l": "AH2 + Co(II)-factor III + S-adenosyl-L-methionine <=> A + Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666216", "l": "RHOA:GTP:RTKN binds TAX1BP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52927", "l": "16alpha,17alpha-estriol + UDP-alpha-D-glucuronate <=> 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381487", "l": "IGFBP1 binds IGF forming IGF:IGFBP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204850", "l": "Interaction of Tie2 and Dok-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19133", "l": "2-oxoglutarate + 3,3',5-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.26", "l": "\"thyroid-hormone transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28010", "l": "propanoyl-CoA + succinate = propanoate + succinyl-CoA", "d": [], "t": []}, {"i": "EC:2.8.3.27", "l": "\"propanoyl-CoA:succinate CoA transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51731", "l": "dihydroxyacetone phosphate + H2O <=> dihydroxyacetone + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9732629", "l": "PPARG binds PPARG agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57261", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GDP => GDP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45145", "l": "3-(methylsulfanyl)acryloyl-CoA + 2 H2O => acetaldehyde + CO2 + CoA + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73110", "l": "acacetin + S-adenosyl-L-methionine <=> apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050089", "l": "mannose isomerase activity", "d": ["Catalysis of the reaction: D-mannose = D-fructose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.3.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30100", "l": "1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+) => 2-demethylmenaquinol-8 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28287", "l": "a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34070", "l": "5-phospho-alpha-D-ribose 1-diphosphate + H(+) + trans,octa-cis-decaprenyl phosphate <=> diphosphate + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824888", "l": "OPTN, TBK1 bind ubiquitinated MOM proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35046", "l": "N-(4-aminobenzoyl)-L-glutamate(in) <=> N-(4-aminobenzoyl)-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156910", "l": "Formation of eEF1B complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15941", "l": "H2O + N(2)-acetyl-L-ornithine = acetate + L-ornithine", "d": [], "t": []}, {"i": "EC:3.5.1.16", "l": "\"acetylornithine deacetylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26417", "l": "a secondary aliphatic amine + H2O + O2 <=> a primary amine + an aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16195", "l": "a (2R)-2-hydroxycarboxylate + a halide anion + H(+) => an (R)-2-haloacid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-422454", "l": "Polysialylation of NCAM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18315", "l": "benzaldehyde + hydrogen cyanide => (R)-mandelonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50784", "l": "dodecanal + NADP(+) = (2E)-dodecenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59262", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64862", "l": "(E)-sinapoyl-CoA + H(+) + S-adenosyl-L-homocysteine => (E)-5-hydroxyferuloyl-CoA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20959", "l": "2-phenylacetate + ATP + CoA <=> AMP + diphosphate + phenylacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63865", "l": "O2 + octadecanoate => (2R)-2-hydroperoxyoctadecanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19403", "l": "formaldehyde + H(+) + NADH => methanol + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13437", "l": "(E)-cinnamate + UDP-alpha-D-glucose = 1-O-(trans-cinnamoyl)-beta-D-glucose + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.177", "l": "\"cinnamate beta-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68608", "l": "H(+) + isatin + NADPH = 3-hydroxyindolin-2-one + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46737", "l": "H2O + monoacyl-sn-glycero-3-phosphate => a monoacylglycerol + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70596", "l": "GOT2 dimer deaminates L-Asp (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77723", "l": "a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside V(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22033", "l": "3-oxalomalate => glyoxylate + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20057", "l": "2 H(+) + H2O + N-carbamoylsarcosine = CO2 + NH4(+) + sarcosine", "d": [], "t": []}, {"i": "EC:3.5.1.59", "l": "\"N-carbamoylsarcosine amidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210282", "l": "Interaction of GPVI and FceRI gamma (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665989", "l": "DIAPH1 binds RHOA:GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5678327", "l": "MIOX oxidises Ins to GlcA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67746", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate => 1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9620456", "l": "sGC stimulators bind sGC:NO (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080012", "l": "trihydroxyferuloyl spermidine O-methyltransferase activity", "d": ["Catalysis of the reaction: trihydroxyferuloyl spermidine + S-adenosyl-L-methionine = dihydroxyferuloyl-sinapoyl spermidine + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73825", "l": "an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18528", "l": "3-methylbutanol + NADP(+) <=> 3-methylbutanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35956", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin B => 6-hydroxytryprostatin B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60894", "l": "a 5'-end phospho-ribonucleoside in snoRNA + H(+) + NAD(+) => a 5'-end NAD(+)-phospho-ribonucleoside in snoRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58047", "l": "a long-chain fatty acyl-CoA + alpha,alpha-trehalose <=> 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32120", "l": "GDP-valienol + validamine 7-phosphate => GDP + H(+) + validoxylamine A 7'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34518", "l": "tri-trans,hepta-cis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047637", "l": "phosphatidylglycerol alanyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61964", "l": "a 1-O-octadecyl-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a 1-O-(1Z-octadecenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38349", "l": "2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate => (S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25202", "l": "D-ribulose 5-phosphate + formaldehyde => D-arabino-hex-3-ulose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26232", "l": "3 NADP(+) + phytyl diphosphate <=> geranylgeranyl diphosphate + 3 H(+) + 3 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71217", "l": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29862", "l": "5'-deoxyadenosine + H2O <=> 5-deoxy-D-ribose + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.34", "l": "\"legumain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9625482", "l": "PTK2 binds activated EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008993", "l": "rhamnulokinase activity", "d": ["Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59225", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + hydropyrene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043722", "l": "4-hydroxyphenylacetate decarboxylase activity", "d": ["Catalysis of the reaction: (4-hydroxyphenyl)acetate + H+ = 4-cresol + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160150", "l": "tRNA pseudouridine(13) synthase activity", "d": ["Catalysis of the reaction: uridine(13) in tRNA = pseudouridine(13) in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114552", "l": "Thrombin-activated PARs activate G12/13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70979", "l": "MDH2 dimer dehydrogenates MAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848436", "l": "PTK6 phosphorylates CDKN1B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.115", "l": "\"3-oxocholoyl-CoA 4-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46375", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944254", "l": "Association of procollagen type XXVI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685156", "l": "ATR phosphorylates RPA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46053", "l": "a 3'-end uridylyl-uridine-RNA => a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445704", "l": "Calcium Binds Caldesmon (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693012", "l": "TNFSF15 binds TNFRSF25 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0008998", "l": "ribonucleoside-triphosphate reductase activity", "d": ["Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11889", "l": "an aldehyde + H2O + NADP(+) => a carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16936", "l": "1-aminocyclopropane-1-carboxylate + H2O <=> 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.98.1.-", "l": "\"Forming coordination complexes\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086059", "l": "SUMOylation of NPM1 with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.7", "l": "\"DNA-directed DNA polymerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134946", "l": "DDX41 ubiquitination by TRIM21 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5631903", "l": "SESN1,2,3 bind overoxidized PRDX1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26021", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate => beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936851", "l": "AHRR binds ARNT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706312", "l": "Active FLT3 binds to LCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22774", "l": "2-dehydro-3-deoxy-L-fuconate + H2O => L-fuconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012268", "l": "ME2 tetramer decarboxylates MAL to PYR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008684", "l": "TBK1 phosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38351", "l": "(R)-3-phenyllactate + NAD(+) = 3-phenylpyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72185", "l": "mRNA polyadenylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58266", "l": "an N-acylsphing-4-enine + cholesteryl 3-beta-D-glucoside => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21802", "l": "all-trans-zeaxanthin + H2O + L-dehydroascorbate => all-trans-antheraxanthin + L-ascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034523", "l": "3-formylsalicylate oxidase activity", "d": ["Catalysis of the reaction: 3-formylsalicylic acid + O2 + H2O = 2-hydroxyisophthalic acid + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9666383", "l": "F8 variant is not cleaved by thrombin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53730", "l": "N-acetyl-D-muramate + phosphate => H2O + N-acetyl-D-muramate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61428", "l": "cis-trans-nepetalactol + NAD(+) = cis-trans-nepetalactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21808", "l": "2,5-dioxopiperazine + H2O = glycylglycine", "d": [], "t": []}, {"i": "EC:3.5.2.13", "l": "\"2,5-dioxopiperazine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17736", "l": "acetylenedicarboxylate + H(+) + H2O <=> CO2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20092", "l": "acetyl-CoA + L-leucine <=> CoA + H(+) + N-acetyl-L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617412", "l": "Expression of GLI1 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39169", "l": "3-oxohexadecanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004651", "l": "polynucleotide 5'-phosphatase activity", "d": ["Catalysis of the reaction: a 5'-phosphopolynucleotide + H2O = a polynucleotide + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13286", "l": "ATP + L-cysteine + L-glutamate => ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783530", "l": "gp130:JAKs bind CNTFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28222", "l": "3-dehydro-L-gulonate + ATP = 3-dehydro-L-gulonate 6-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31605", "l": "(Z)-3-aminoacrylate + carbamate + H(+) => (Z)-3-ureidoacrylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37177", "l": "1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41453", "l": "5-methyl-1-naphthoate + H(+) + NADPH + O2 => 3-hydroxy-5-methyl-1-naphthoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849094", "l": "ARHGAP35 binds RASA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389463", "l": "Proteinase-activated receptors can bind thrombin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033795", "l": "betaine reductase activity", "d": ["Catalysis of the reaction: [thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine = [thioredoxin]-dithiol + glycine betaine + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810392", "l": "TMEM55B translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9733969", "l": "Bile salts dissociate from FABP6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11333", "l": "ATP + RNA(n) => diphosphate + RNA(n)-3'-adenine ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35784", "l": "neamine + UDP-alpha-D-kanosamine => H(+) + kanamycin B + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799196", "l": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162840", "l": "Reorientation of glucosaminyl-acyl-PI in the endoplasmic reticulum membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032018", "l": "2-methylbutanal reductase (NADPH) activity", "d": ["Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11284", "l": "hydroxymalonate + NAD(+) = H(+) + NADH + oxomalonate", "d": [], "t": []}, {"i": "EC:1.1.1.167", "l": "\"hydroxymalonate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.18", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56819", "l": "a pyrimidine ribonucleoside + H2O <=> a pyrimidine nucleobase + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047624", "l": "adenosine-tetraphosphatase activity", "d": ["Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140562", "l": "EGF-domain serine xylosyltransferase activity", "d": ["Catalyses the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66372", "l": "H2O + sn-glycerol 3-phosphate = glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941895", "l": "Formation of CDK4/6:CCND complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55480", "l": "ent-cassa-12,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = ent-3beta-hydroxycassa-12,15-dien-2-one + 3 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.69", "l": "\"ent-cassadiene hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140786", "l": "glutamine sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of glutamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42458", "l": "zymosterol => 4alpha-methylzymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39634", "l": "(2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH <=> (16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68185", "l": "a medium-chain fatty acyl-CoA + H2O => a medium chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014456", "l": "GDIs block activation of RHOG (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.-", "l": "\"Acting on acid anhydrides; catalyzing transmembrane movement of substances\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.86", "l": "\"ADAM 17 endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318415", "l": "ATF2 acetylates histone H2B, H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868236", "l": "BAR domain proteins recruit dynamin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854209", "l": "TBC1D10A binds JFC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948641", "l": "miR-106 microRNAs bind VAPA mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20212", "l": "ATP + xylitol <=> ADP + H(+) + xylitol 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32482", "l": "2 iodide + L-tyrosine + 2 NADP(+) <=> 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507869", "l": "Aquaporins passively transport glycerol into cells (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877153", "l": "STARD7 binds PC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54400", "l": "1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51613", "l": "(R)-2-hydroxyglutarate + oxaloacetate => (R)-malate + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696271", "l": "RND1 binds effectors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59672", "l": "D-maltotriose + O2 = D-maltotriono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57632", "l": "ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + ML-236A carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169192", "l": "PTP1B dephosphorylates GHR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25044", "l": "H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate <=> L-selenocysteinyl-tRNA(Sec) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30357", "l": "a quinone + H2O + methanol => a quinol + methane + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047133", "l": "dimethylamine dehydrogenase activity", "d": ["Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41320", "l": "1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018785", "l": "RHOBTB2 binds GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789185", "l": "Chloride ion and N-acyl group react to chloramide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50013", "l": "H(+) + NADPH + O2 + tert-butanol => 2-methylpropane-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034876", "l": "isonicotinic acid hydrazide hydrolase activity", "d": ["Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78868", "l": "a medium-chain (3R)-hydroxyacyl-CoA => a medium-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021068", "l": "PalmS-ESRs bind CAVs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75621", "l": "ectocarpin C => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73454", "l": "adenosine 3',5'-bisphosphate(in) + AMP(out) <=> adenosine 3',5'-bisphosphate(out) + AMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32546", "l": "(2E)-geranyl diphosphate + H2O <=> 1,8-cineole + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41227", "l": "(S)-4-hydroxymandelate + O2 = 4-hydroxyphenylglyoxylate + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.46", "l": "\"4-hydroxymandelate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044197", "l": "Rel homology domain binding", "d": ["Binding to a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793591", "l": "LIAS synthesizes lipoyl-GCSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75780", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoate + H2O => (10S)-hydroxy-(6Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12818", "l": "2,3-dihydrobiochanin A + NADP(+) => biochanin A + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40422", "l": "H2O + phytanoyl-CoA <=> 3,7,11,15-tetramethylhexadecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11026", "l": "ADP + 2 H(+) + phosphoramidate => ATP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71890", "l": "GTP + NAD(+) <=> H(+) + N(2)-(ADP-D-ribosyl)-GTP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52004", "l": "H2O + methylglyoxal + NAD(+) = 2 H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57737", "l": "A + all-trans-3,4-didehydro-13,14-dihydroretinol => AH2 + all-trans-3,4-didehydroretinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37062", "l": "adenosine(37) in tRNA + L-threonylcarbamoyladenylate <=> AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34712", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine => 15-methylhexadecasphing-4-enine + a fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218819", "l": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399930", "l": "Activation of PAK by Rac1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63279", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 <=> a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030339", "l": "fatty-acyl-ethyl-ester synthase activity", "d": ["Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37171", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015304", "l": "glucose uniporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in)."], "t": []}, {"i": "RHEA:60376", "l": "D-glucose(out) = D-glucose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2976551", "l": "NOTCH2 stimulates GZMB transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.58", "l": "\"2-dehydro-3-deoxygalactonokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64309", "l": "3-aminobutanoate + pyruvate => acetoacetate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734572", "l": "Expression of MEF2C in cardiogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39590", "l": "3-oxo-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10866", "l": "2-(acetamidomethylene)succinate + NADP(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804383", "l": "PRMT5 methylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033918", "l": "kappa-carrageenase activity", "d": ["Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654224", "l": "Activated FGFR3 binds PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62060", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP-beta-L-fucose = alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52868", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209055", "l": "PPM1A dephosphorylates nuclear SMAD2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75969", "l": "(6-hydroxyhexanoyl)n-1 + 6-hydroxyhexanoate + H(+) => (6-hydroxyhexanoyl)n + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050167", "l": "pantothenoylcysteine decarboxylase activity", "d": ["Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H+ = (R)-pantetheine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63691", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638845", "l": "CERK phosphorylates CERA to form C1P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9692738", "l": "HRH2 binds HRH2 antagonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.63", "l": "\"oryzin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955844", "l": "RBKS phosphorylates ribose to R5P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21341", "l": "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 => 2 vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350436", "l": "DGO binds to DSH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0016411", "l": "acylglycerol O-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15770", "l": "adenosylcob(III)inamide + ATP => adenosylcob(III)inamide phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66725", "l": "(S)-lactate + L-phenylalanine => H2O + N-[(S)-lactoyl]-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14637", "l": "3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + H(+) + S-alkyl thiosulfate", "d": [], "t": []}, {"i": "EC:2.8.2.16", "l": "\"thiol sulfotransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21188", "l": "ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)", "d": [], "t": []}, {"i": "EC:6.3.1.5", "l": "\"NAD(+) synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218814", "l": "PAK2 autophorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59051", "l": "D-ornithine + H(+) <=> CO2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2090037", "l": "IDUA hydrolyses Heparan sulfate chain(6) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852716", "l": "Thrombin, ELANE cleave C5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051116", "l": "cobaltochelatase activity", "d": ["Catalysis of the reaction: ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 4 H+ + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67027", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48420", "l": "a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193695", "l": "IRAK interacts with TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66025", "l": "hypobromite + L-lysyl-[collagen] + L-methionyl-[collagen] => [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700184", "l": "Ligand-independent dimerization of point mutants of ALK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68367", "l": "4-CDP-2-C-methyl-D-erythritol <=> 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429767", "l": "Passive I- efflux mediated by SLC5A8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109858", "l": "MAP2K2 binds MAPK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379993", "l": "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67537", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0032841", "l": "calcitonin binding", "d": ["Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52484", "l": "(3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0046524", "l": "sucrose-phosphate synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796072", "l": "NFE2L2 dependent PDGFA expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44883", "l": "ATP + L-threonyl-[receptor-protein] <=> ADP + H(+) + O-phospho-L-threonyl-[receptor-protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15361", "l": "a dolichyl phosphate + UDP-alpha-D-xylose = a dolichyl D-xylosyl phosphate + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.32", "l": "\"dolichyl-phosphate D-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170986", "l": "Ral-GDS binds to Ras-GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917839", "l": "apo-Transferrin dissociates from the receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019162", "l": "pyridoxamine-oxaloacetate transaminase activity", "d": ["Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24368", "l": "L-ornithine = L-proline + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.12", "l": "\"ornithine cyclodeaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0003973", "l": "(S)-2-hydroxy-acid oxidase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875374", "l": "MET binds LRIG1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140825", "l": "TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030270", "l": "formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity", "d": ["Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H+ = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877922", "l": "BGLAP gene expression is stimulated by RUNX2, WWTR1 and RB1 and inhibited by AR, YAP1 and ZNF521 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52752", "l": "H2O + isomaltose = beta-D-glucose + D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.205", "l": "\"isomaltose glucohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54357", "l": "3-methyl-2-oxobutanoate + H(+) => 2-methylpropanal + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729870", "l": "KCNJ2 (KIR2.1) transports K+ from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013069", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371591", "l": "Trimerization of cytosolic HSF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389622", "l": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805126", "l": "AURKB phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52103", "l": "5-(9Z-octadecenoyloxy)-octadecanoate + H2O <=> (9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25610", "l": "beta-D-allofuranose => beta-D-allopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202233", "l": "Inactivation of Lck by Csk (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32071", "l": "geranylgeranyl diphosphate = (13E)-labda-7,13-dien-15-yl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5623527", "l": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41284", "l": "H2O + N-tetracosanoyl-sphing-4-enine => sphing-4-enine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71496", "l": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71308", "l": "chloride(out) + L-valine(out) + 2 Na(+)(out) => chloride(in) + L-valine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77019", "l": "2-aminocyclohexanol + H2O + NAD(+) = 2-hydroxycyclohexan-1-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159001", "l": "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70562", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O <=> L-threonyl-[protein] + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12210", "l": "4-methylumbelliferone + acetate + H(+) => 4-methylumbelliferyl acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-372819", "l": "PCK2 phosphorylates OA to yield PEP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76752", "l": "5-hydroxydodecanoate + H(+) => delta-dodecalactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0070569", "l": "uridylyltransferase activity", "d": ["Catalysis of the transfer of an uridylyl group to an acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13353", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol = 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.14", "l": "\"CDP-ribitol ribitolphosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2574845", "l": "AJUBA binds centrosome-associated AURKA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75873", "l": "Addition of Nucleotides 5 through 9 on the growing Transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56836", "l": "[PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:1.21.98.4", "l": "\"PqqA peptide cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59304", "l": "3'-phosphoadenylyl sulfate + firefly L-luciferin = adenosine 3',5'-bisphosphate + firefly L-sulfoluciferin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54095", "l": "3,4-dihydroxyphenylacetate + H(+) + NADPH + O2 <=> 2,4,5-trihydroxyphenylacetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77646", "l": "adenosine 2',5'-bisphosphate + H2O <=> AMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710323", "l": "TP53 or TP63 binds the GSDME gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004813", "l": "alanine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40667", "l": "2-aminoprop-2-enoate = 2-iminopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32953", "l": "trehalulose => sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39782", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75214", "l": "Cu(+)(out) <=> Cu(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983150", "l": "Proteasomal cleavage of substrate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295632", "l": "PPA2A dephosphorylates SPRY2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41790", "l": "acetyl-[ACP] + CoA => acetyl-CoA + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373724", "l": "Nephrin binds NCK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10484", "l": "H2O + N-feruloylglycine = (E)-ferulate + glycine", "d": [], "t": []}, {"i": "EC:3.5.1.71", "l": "\"N-feruloylglycine deacylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-451309", "l": "Edited Kainate Receptor binds glutamate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2197698", "l": "Src phosphorylate WASP,N-WASP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26416", "l": "a primary amine + an aldehyde + H2O2 => a secondary aliphatic amine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647994", "l": "RAS proteins are depalmitoylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3341277", "l": "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033763", "l": "proline 3-hydroxylase activity", "d": ["Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78016", "l": "a 1,2-diacylglycerol + H2O => a 2-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2214351", "l": "PLK1 phosphorylates GORASP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198824", "l": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867044", "l": "EGFR binds EPS15, EPN1, EPS15L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25104", "l": "ATP + pyridoxamine = ADP + H(+) + pyridoxamine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41602", "l": "1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160874", "l": "HYAL1 hydrolyses (HA)50 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30692", "l": "H2O2 + methanol => formaldehyde + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71516", "l": "hypoxanthine(out) => hypoxanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266350", "l": "CETP-mediated lipid exchange: LDL gains cholesterol ester (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51572", "l": "(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061751", "l": "neutral sphingomyelin phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+ in a neutral environment."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210947", "l": "pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35742", "l": "cholesterol + 6 H(+) + 3 O2 + 6 reduced [adrenodoxin] <=> 4-methylpentanal + 4 H2O + 6 oxidized [adrenodoxin] + pregnenolone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654573", "l": "Activated FGFR1 binds SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40597", "l": "CoA + dodecanedioate + H(+) => dodecanedioyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18776", "l": "coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein] <=> Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16206", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] => N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39958", "l": "(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11518", "l": "CoA + H(+) + succinate => H2O + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-197958", "l": "FPGS-2 transforms THF to THFPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043813", "l": "phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418858", "l": "RhoGTPase GEF's recruited to DCC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57580", "l": "S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thiol-D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70577", "l": "H(+) + UMP => 3',5'-cyclic UMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49984", "l": "H(+) + jasmonate + NADPH + O2 = (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.228", "l": "\"jasmomic acid 12-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680349", "l": "CSF1R dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-622415", "l": "RIP2 binds NEMO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9842115", "l": "PSAP(195-273) dimer binds PE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106420", "l": "NAD-dependent protein biotinidase activity", "d": ["Catalysis of the reaction: H2O + N6-biotinyl-L-lysyl-[protein] + NAD+ = 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:70479", "l": "H2O + N(6)-biotinyl-L-lysyl-[protein] + NAD(+) = 2''-O-biotinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796626", "l": "MIB2 ubiquitinates CFLAR  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25078", "l": "(2S)-2-isopropyl-3-oxosuccinate + H(+) = 4-methyl-2-oxopentanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254291", "l": "ERBB4s80 binds STAT5A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730872", "l": "Activation of Calcineurin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30194", "l": "15-cis-phytoene + plastoquinone-9 <=> 15,9'-di-cis-phytofluene + plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74976", "l": "a (3R)-3-isocyanyl-fatty acyl-AMP + holo-[ACP] => a (3R)-3-isocyanyl-fatty acyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.323347803118935", "identifiers": [{"i": "GO:0098531", "l": "ligand-activated transcription factor activity", "d": ["A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9816396", "l": "DUX4, TPRXL, TPRX1, TPRX2, EP300, and CREBBP bind the ZSCAN4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53258", "l": "7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lathosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58196", "l": "H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]", "d": [], "t": []}, {"i": "EC:3.5.1.98", "l": "\"histone deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74601", "l": "AMP(in) + UDP-alpha-D-galactose(out) => AMP(out) + UDP-alpha-D-galactose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47789", "l": "a cytidine in 28S rRNA + S-adenosyl-L-methionine => a 5-methylcytidine in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74632", "l": "3-methyl-2-oxobutanoate + O-acetyl-L-homoserine => (6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56775", "l": "2 AH2 + all-trans-adonixanthin + 2 O2 <=> 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008840", "l": "4-hydroxy-tetrahydrodipicolinate synthase activity", "d": ["Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010329", "l": "auxin efflux transmembrane transporter activity", "d": ["Enables the transfer of auxin, from one side of a membrane to the other, out of a cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9761421", "l": "CDH11 associates with catenins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33060", "l": "(R)-dihydrolipoamide + NAD(+) => (R)-lipoamide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23357", "l": "ATP + L-seryl-[rhodopsin] => ADP + H(+) + O-phospho-L-seryl-[rhodopsin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9737780", "l": "MTTP binds lomitapide (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41145", "l": "1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+) => 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8941623", "l": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218814", "l": "PAK2 autophorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000277", "l": "[cytochrome c]-lysine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34716", "l": "15-methylhexadecasphing-4-enine + ATP => 15-methylhexadecasphing-4-enine 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78562", "l": "(3S)-hydroxytetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78895", "l": "a very long-chain fatty acyl-CoA + acetyl-CoA = a very-long-chain 3-oxoacyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0005537", "l": "D-mannose binding", "d": ["Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans."], "t": []}, {"i": "REACT:R-HSA-947991", "l": "Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69039", "l": "5beta-androstane-3,17-dione + H(+) + NADPH <=> 3beta-hydroxy-5beta-androstane-17-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649856", "l": "Oxidative damage to the AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9038163", "l": "ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27987", "l": "hydroxyacetone + NADP(+) => H(+) + methylglyoxal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32793", "l": "L-ectoine(out) => L-ectoine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205008", "l": "Polyubiquitinated NRIF binds to p62 (Sequestosome) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050597", "l": "taxane 10-beta-hydroxylase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67976", "l": "all-trans-neurosporene = beta-zeacarotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31765", "l": "4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid => a 2-oxocarboxylate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033957", "l": "lambda-carrageenase activity", "d": ["Catalysis of the endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5577050", "l": "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18435", "l": "cyclohexanone + H2O2 + NH4(+) => cyclohexylamine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35997", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54180", "l": "a long-chain fatty aldehyde + holo-[ACP] + NAD(+) = a long-chain fatty acyl-[ACP] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877360", "l": "RUNX1 binds the IFNG promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-399939", "l": "Autophosphorylation of PAK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449087", "l": "CD4 binds Interleukin-16 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50232", "l": "8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.20", "l": "\"heme oxygenase (biliverdin-producing, ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203565", "l": "eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41855", "l": "H(+) + malonyl-[ACP] + octanoyl-[ACP] <=> 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036020", "l": "Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)8 (PP-Dol)1 by ALG9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0016653", "l": "oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein."], "t": []}, {"i": "EC:1.6.2.-", "l": "\"With a heme protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047474", "l": "long-chain fatty acid--protein ligase activity", "d": ["Catalysis of the reaction: a long-chain fatty acid + ATP + L-cysteinyl-[protein] = AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008429", "l": "phosphatidylethanolamine binding", "d": ["Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48898", "l": "3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63700", "l": "mycophenolate + UDP-alpha-D-glucuronate = mycophenolic acid O-acyl-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31616", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine => dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51342", "l": "10-hydroperoxy-(4Z,7Z,11E,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005300", "l": "high-affinity tryptophan transmembrane transporter activity", "d": ["Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47794", "l": "5-methylcytidine(4447) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(4447) in 28S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24067", "l": "2 5-aminolevulinate <=> H(+) + 2 H2O + porphobilinogen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23904", "l": "an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]", "d": [], "t": []}, {"i": "EC:2.3.2.2", "l": "\"gamma-glutamyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018489", "l": "vanillate monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-203613", "l": "depalmitoylation of eNOS (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61050", "l": "H(+) + H2O + horhammericine + oxidized [NADPH--hemoprotein reductase] => lochnericine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624800", "l": "CDK1 phosphorylates LBR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48765", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) => 3-acetyl-3-devinylchlorophyllide a + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74159", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070300", "l": "phosphatidic acid binding", "d": ["Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58254", "l": "ADP-D-ribose + L-asparaginyl-[protein] => H2O + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77877", "l": "2-dehydro-D-glucose + L-leucine => (2S)-4-methyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]pentanoate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19638", "l": "D-nopaline + H2O + NADP(+) => 2-oxoglutarate + H(+) + L-arginine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15251", "l": "1-O-galloyl-beta-D-glucose + UDP => 3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9677579", "l": "CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70342", "l": "alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O <=> beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191654", "l": "c-src associates with Cx43 in gap junctions (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810410", "l": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428259", "l": "DEGS1 dehydrogenates dihydroceramide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40920", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15058", "l": "(9Z)-octadecenoyl-[ACP] + H2O => (9Z)-octadecenoate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714481", "l": "RAC2 binds effectors at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70893", "l": "L-asparagine(in) + L-glutamine(out) + Na(+)(in) => L-asparagine(out) + L-glutamine(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60008", "l": "a tRNA precursor + 2 CTP = a tRNA with a 3' CC end + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0003913", "l": "DNA photolyase activity", "d": ["Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483186", "l": "PC is converted to PS by PTDSS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050535", "l": "beta-primeverosidase activity", "d": ["Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683385", "l": "Formation of BRCA1-A complex at DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37146", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19840", "l": "D-sorbitol 6-phosphate + NAD(+) <=> beta-D-fructose 6-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17680", "l": "2-(acetamidomethylene)-3-(hydroxymethyl)succinate + H(+) + 2 H2O <=> 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74559", "l": "aldosterone = aldosterone hemiacetal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698000", "l": "FLT3 mutants:GRB2 bind GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388900", "l": "Neurotensin receptors can bind neurotensins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55546", "l": "H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine => L-lysyl-[citrate synthase] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20750", "l": "CO2 + deacetoxycephalosporin C + H2O + succinate => 2-oxoglutarate + O2 + penicillin N", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950181", "l": "Y693-STAT4 dimer translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75171", "l": "GTP + NAD(+) = GDP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782893", "l": "TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.33", "l": "\"4-hydroxybenzoate 3-monooxygenase [NAD(P)H]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020271", "l": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "64.962680676965917", "identifiers": [{"i": "GO:0016836", "l": "hydro-lyase activity", "d": ["Catalysis of the cleavage of a carbon-oxygen bond by elimination of water."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65374", "l": "a globoside MSGG + CMP + H(+) => a globoside GalGb4Cer + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46671", "l": "21-hydroxyprogesterone + H(+) + NADPH <=> 5beta-dihydrodeoxycorticosterone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452958", "l": "Expression of SALL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36762", "l": "N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine <=> alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799431", "l": "TP53 binds HIPK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8870466", "l": "RGGT:CHM binds RABs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31043", "l": "(S)-2-methyl-3-oxopropanoate + H2O + NAD(+) = 2 H(+) + methylmalonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49749", "l": "2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate => CO2 + 2 H2O + NADP(+) + proviolacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9865630", "l": "Metallochaperone inserts 2Cu2+ into MT-CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31878", "l": "(S)-2,3-epoxysqualene <=> marneral", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111751", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662114", "l": "ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166869", "l": "TRAF6 binds MEKK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74723", "l": "Endosome acidification (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701141", "l": "TRPV1 transports Ca2+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140761", "l": "sequestered tissue factor -> tissue factor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449087", "l": "CD4 binds Interleukin-16 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381612", "l": "GLP1R binds GLP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52549", "l": "L-threonate + NAD(+) => 2-dehydro-L-erythronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11694", "l": "NADH + NADP(+) => NAD(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43729", "l": "methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799981", "l": "PGLYRP2 binds bacterial peptidoglycan (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693598", "l": "ATM phosphorylates NBN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004845", "l": "uracil phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102464", "l": "zeaxanthin 2-beta-hydroxylase activity", "d": ["Catalysis of the reaction: zeaxanthin + O2 + NADH + H+ = caloxanthin + H2O + NAD."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9727567", "l": "CES1 hydrolyses sacubitril to sacubitrilat (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32215", "l": "(6R)-NADHX = (6S)-NADHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32593", "l": "(3R,6S)-6-hydroxy-3,7-dimethyloctanoate + H(+) => (4R,7S)-7-isopropyl-4-methyloxepan-2-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41033", "l": "1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695853", "l": "FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25993", "l": "(2E,6E)-farnesyl diphosphate => (+)-epi-isozizaene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54520", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = cycloaraneosene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.191", "l": "\"cycloaraneosene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218821", "l": "PDK1 phosphorylates PKC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614544", "l": "Sulfite is oxidized to sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58152", "l": "H2O + NAD(+) + phosphonoacetaldehyde = 2 H(+) + NADH + phosphonoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25826", "l": "H2O2 + N-(3-aminopropyl)-4-aminobutanal + propane-1,3-diamine => H2O + O2 + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68011", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35426", "l": "an anthocyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> an anthocyanidin 3,5-di-O-beta-D-glucoside + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76308", "l": "L-aspartate(in) + L-glutamate(out) => L-aspartate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047838", "l": "D-xylose 1-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22513", "l": "3 H(+) + precorrin-8X => hydrogenobyrinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018662", "l": "phenol 2-monooxygenase activity", "d": ["Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019826", "l": "oxygen sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160935", "l": "SMURF1 ubiquitinates RHOA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22379", "l": "uridine(38/39/40) in tRNA <=> pseudouridine(38/39/40) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25938", "l": "8-methylquinolin-2(1H)-one + AH2 => 8-methylquinoline + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23428", "l": "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74574", "l": "H2O + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] <=> N(alpha)-acetyl-L-methionine + N-terminal L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20286", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate => alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102777", "l": "caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin-3,5-diglucoside-5-O-caffeoylglucoside + coenzyme A(4-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984606", "l": "Kinesin-5 is a homotetramer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52952", "l": "lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64687", "l": "L-threonyl-[protein] + UDP-alpha-D-glucose <=> 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018642", "l": "chlorophenol 4-monooxygenase activity", "d": ["Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26386", "l": "all-trans-8'-apo-beta-carotenal + O2 => (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + all-trans-retinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375160", "l": "NCAM1 binds to ATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64369", "l": "2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A => 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54805", "l": "2 4-sulfanylbutanoate + NAD(+) => 4,4'-disulfanyldibutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.34", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730882", "l": "Phosphorylation of PKC-theta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018594", "l": "tert-butanol 2-monooxygenase activity", "d": ["Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62296", "l": "(+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+) = (+)-malbrancheamide + 2 FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0023030", "l": "MHC class Ib protein binding, via antigen binding groove", "d": ["Binding to a major histocompatibility complex class Ib molecules via the antigen binding groove."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855233", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48752", "l": "2-oxoglutarate + O2 + validamycin A = CO2 + H(+) + succinate + validamycin B", "d": [], "t": []}, {"i": "EC:1.14.11.52", "l": "\"validamycin A dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658483", "l": "Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54188", "l": "H2O + N-acetyl-L-phenylalanine = acetate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75856", "l": "Abortive Initiation Before Second Transition (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.207", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050192", "l": "phosphoglycerate phosphatase activity", "d": ["Catalysis of the reaction: 2-phospho-D-glycerate + H2O = D-glycerate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093332", "l": "p-EPHB phosphorylates SDC2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44339", "l": "an L-alpha-amino acid + ATP + L-arginine <=> ADP + H(+) + L-arginyl-L-alpha-amino acid + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47650", "l": "phosphate + ribitol => D-ribitol 5-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194669", "l": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32795", "l": "ATP + H2O + L-cysteine(out) = ADP + H(+) + L-cysteine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730867", "l": "Translocation of CaN:CaM:NFAT to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31131", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047533", "l": "2,5-dioxovalerate dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58955", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rh1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36324", "l": "(9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH => (9Z)-octadecen-1-ol + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113409", "l": "Abortive termination of early transcription elongation by DSIF:NELF (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0030745", "l": "dimethylhistidine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha,N-alpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20331", "l": "ADP + H(+) + O-phospho-L-seryl-[low-density-lipoprotein receptor] => ATP + L-seryl-[low-density-lipoprotein receptor]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.110", "l": "\"ureidoacrylate amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32511", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O = (3R,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56815", "l": "2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 <=> 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65823", "l": "decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54820", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74820", "l": "glutathione(in) => glutathione(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20481", "l": "3'-phosphoadenylyl sulfate + coelenterazine h = adenosine 3',5'-bisphosphate + H(+) + luciferyl sulfate", "d": [], "t": []}, {"i": "EC:2.8.2.10", "l": "\"Renilla-luciferin sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395412", "l": "Phosphorylation of SYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004819", "l": "glutamine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67191", "l": "ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out) <=> ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23391", "l": "ATP + hygromycin B <=> 7''-O-phosphohygromycin B + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62375", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77001", "l": "NADH + oxidized [4Fe-4S]/[3Fe-4S]-[ferredoxin] => H(+) + NAD(+) + reduced [4Fe-4S]/[3Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14682", "l": "2 2-aminophenol + A + O2 => 2-aminophenoxazin-3-one + AH2 + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15809", "l": "(2E)-geranyl diphosphate + H2O = (R)-linalool + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.26", "l": "\"R-linalool synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31046", "l": "(S)-2-methyl-3-oxopropanoate + H2O + NAD(+) <=> 2 H(+) + methylmalonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051907", "l": "S-(hydroxymethyl)glutathione synthase activity", "d": ["Catalysis of the reaction: S-(hydroxymethyl)glutathione = formaldehyde + glutathione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018808", "l": "trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity", "d": ["Catalysis of the reaction: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38981", "l": "1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24894", "l": "5-hydroxyxanthotoxin + S-adenosyl-L-methionine = isopimpinellin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31843", "l": "2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-oxepin-2(3H)-ylideneacetyl-CoA", "d": [], "t": []}, {"i": "EC:5.3.3.18", "l": "\"2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54331", "l": "2 H(+) + hexadecanoyl-[ACP] + 2 NADPH <=> hexadecan-1-ol + holo-[ACP] + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60712", "l": "(+)-artemisinic alcohol + NAD(+) = (+)-artemisinic aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56205", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] => 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44546", "l": "a fatty acid(in) + ADP + H(+) + phosphate => a fatty acid(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420688", "l": "GABAB heterodimeric receptor binds GABA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48757", "l": "erythritol + NAD(+) => D-erythrulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44312", "l": "1-tetradecanoylglycerol + H2O = glycerol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26210", "l": "L-allo-threonine => acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27887", "l": "2',3'-cyclophospho-AMP + H2O => 3'-AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78550", "l": "Rb(+)(in) <=> Rb(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205867", "l": "PRMT1 methylates arginine-12 of histone H2A (H2AR11) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018768", "l": "RHOU auto-activates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14657", "l": "aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.6", "l": "\"ribose-5-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32770", "l": "cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21380", "l": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA", "d": [], "t": []}, {"i": "EC:6.2.1.24", "l": "\"phytanate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77730", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol <=> 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852280", "l": "GTSE1 binds microtubule lattice in interphase cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868118", "l": "MAPK12 phosphorylates PTPN3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28667", "l": "H(+) + hydroxyacetone + NADH = (S)-propane-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874197", "l": "CREB3 translocates from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14721", "l": "UDP-alpha-D-xylose + zeatin = H(+) + O-beta-D-xylosylzeatin + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.40", "l": "\"zeatin O-beta-D-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42896", "l": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.297", "l": "\"peptide chain release factor N(5)-glutamine methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18773", "l": "coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein] = Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9612219", "l": "ERBB4s80 binds to SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35999", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218805", "l": "PKC autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174367", "l": "GCL ligates L-Glu to L-Cys (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399985", "l": "AKT1 E17K mutant phosphorylates caspase-9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879411", "l": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9859172", "l": "DLD dimer dehydrogenates dihydrolipoyl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41559", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2 <=> (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090440", "l": "abscisic acid transmembrane transporter activity", "d": ["Enables the transfer of abscisic acid from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23103", "l": "ATP + dAMP <=> ADP + dADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44098", "l": "CoA + decanyl hexadecanoate => decan-1-ol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.7", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047668", "l": "amygdalin beta-glucosidase activity", "d": ["Catalysis of the reaction: (R)-amygdalin + H2O = (R)-prunasin + D-glucose."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30179", "l": "oxalate + oxidized 2[4Fe-4S]-[ferredoxin] = 2 CO2 + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.2.7.10", "l": "\"oxalate oxidoreductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.96", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380316", "l": "Association of NuMA with microtubules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004401", "l": "histidinol-phosphatase activity", "d": ["Catalysis of the reaction: L-histidinol phosphate + H2O = L-histidinol + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.121", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32809", "l": "thiosulfate(out) => thiosulfate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102837", "l": "1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26009", "l": "di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate <=> beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1299507", "l": "Methylthio-ribulose-P = Methylthio-ribose-P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26507", "l": "(9Z)-octadecenamide + H2O => (9Z)-octadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693540", "l": "MRN activates ATM (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64622", "l": "(E)-sinapoyl actetate + CoA => (E)-sinapyl alcohol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203893", "l": "Microprocessor complex cleaves pri-miRNA to pre-miRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33775", "l": "a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944255", "l": "Association of procollagen type VII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42151", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acyl-(4R)-4-hydroxysphinganine <=> a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34797", "l": "alpha-D-ribose 1,5-bisphosphate + H(+) => alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47990", "l": "3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH => 2-dehydro-3-deoxy-L-galactonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54819", "l": "L-glutaminyl-[protein] + L-lysyl-[protein] <=> [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60648", "l": "an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2980720", "l": "NEK9 binds NEK6/NEK7 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67508", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59092", "l": "[(1->3)-alpha-D-glucosyl](n) + sucrose = [(1->3)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}, {"i": "EC:2.4.1.372", "l": "\"mutansucrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42279", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] <=> (4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25303", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O => 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51673", "l": "glyoxal + H2O => glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732729", "l": "Activated JAK1 binds RAF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9824986", "l": "XPO1-dependent export of p-S69,S73 MITF-M (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950485", "l": "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17973", "l": "diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75244", "l": "FASL binds FAS Receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60613", "l": "1-octanoyl-sn-glycero-3-phosphocholine => 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018825", "l": "RHOT2 GEFs activate RHOT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381091", "l": "IRE1 dimer autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55331", "l": "9-cis-retinol + hexadecanoyl-CoA <=> 9-cis-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56208", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] = 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24179", "l": "[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63191", "l": "3,4-dihydroxybenzaldehyde + AH2 + tyramine <=> A + H2O + norbelladine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78955", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10359", "l": "3alpha-hydroxy-5beta-androstan-17-one + NAD(+) <=> 5beta-androstane-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56703", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(Z)-2-isocyanoethenyl]-1H-indole + 2 CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63802", "l": "GDP-beta-L-gulose => GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683964", "l": "ATM phosphorylates EYA1-4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37937", "l": "8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O => (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64584", "l": "2-hydroxyethane-1-sulfonate(out) + Na(+)(out) = 2-hydroxyethane-1-sulfonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45914", "l": "a 4,5-saturated-(3E)-enoyl-CoA + NADP(+) => a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022411", "l": "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102439", "l": "3',4',5'-trimethylmyricetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine = 7,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49286", "l": "CMP-8-amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate => 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011950", "l": "Estrogen-responsive GREB1 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781953", "l": "YOD1 binds VCP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084990", "l": "Nuclear CMP-Neu5Ac translocates to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10618", "l": "(2R,3S,4S)-leucocyanidin + H(+) + NADPH => (2R,3S)-catechin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177941", "l": "GRB2:GAB1 binds to phosphorylated EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9824897", "l": "p-S-TBK1 phosphorylates OPTN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139914", "l": "Translocation of BBC3 (PUMA) protein to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20917", "l": "L-cysteine + sulfite => hydrogen sulfide + L-cysteate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672961", "l": "PP2A dephosphorylates inactive RAFs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16793", "l": "H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.36", "l": "\"phosphopantothenoylcysteine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59318", "l": "D-cellobiono-1,5-lactone + H2O2 => D-cellobiose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735439", "l": "Expression of MYOCD in cardiogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66663", "l": "ATP + beta-D-glucosylceramide(in) + H2O <=> ADP + beta-D-glucosylceramide(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34403", "l": "9-cis-10'-apo-beta-carotenal + 2 O2 = (11R)-carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal", "d": [], "t": []}, {"i": "EC:1.13.11.69", "l": "\"carlactone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983078", "l": "p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30156", "l": "FADH2 + 2 Fe(3+) => FAD + 2 Fe(2+) + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62910", "l": "H(+) + S-adenosyl-L-homocysteine + toralactone => nor-toralactone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-507873", "l": "Aquaporins passively transport urea out of cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17611", "l": "3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine => L-seryl-[sulfatase] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47341", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71164", "l": "H(+)(in) + L-alanine(out) + Na(+)(out) => H(+)(out) + L-alanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23099", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17943", "l": "2-methyl-cis-aconitate + H2O => (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018449", "l": "1-phenylethanol dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-1-phenylethanol + NAD+ = acetophenone + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004523", "l": "RNA-DNA hybrid ribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0004517", "l": "nitric-oxide synthase activity", "d": ["Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009817", "l": "Acitretin binds to RAR:RXR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26260", "l": "dehydroabietadienol + H(+) + NADPH + O2 <=> dehydroabietadienal + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102297", "l": "selenate adenylyltransferase activity", "d": ["Catalysis of the reaction: selenic acid + ATP + 2 H+ = adenylyl selenate + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64552", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] = 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16393", "l": "H2O + juvenile hormone II = H(+) + juvenile hormone II carboxylate + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019153", "l": "protein-disulfide reductase (glutathione) activity", "d": ["Catalysis of the reaction: 2 glutathione + protein-disulfide = glutathione disulfide+ protein-dithiol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74726", "l": "Dissociation of insulin from insulin receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34775", "l": "a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3-oxosteroid + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57016", "l": "3,6-dichloro-2-methoxybenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,6-dichlorosalicylate + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53835", "l": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 <=> a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58888", "l": "4-aminobenzoate + AH2 + 2 O2 = 4-nitrobenzoate + A + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.99.68", "l": "\"4-aminobenzoate N-oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25954", "l": "2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6788623", "l": "p-Y-STATs translocate to nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78615", "l": "ATP + H(+) + L-lysine = diphosphate + L-lysyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012835", "l": "GDIs block activation of RHOA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9731931", "l": "EDNRA binds selective ERAs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74386", "l": "2 (S)-lactate(in) + prostaglandin E2(out) <=> 2 (S)-lactate(out) + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-549129", "l": "OCT1 transports organic cations into hepatic cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32648", "l": "erythromycin C + S-adenosyl-L-methionine => erythromycin A + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183051", "l": "CBL ubiquitinates Sprouty (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68126", "l": "a triacylglycerol + holo-[ACP] => a 1,2-diacylglycerol + a fatty acyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047669", "l": "amylosucrase activity", "d": ["Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950113", "l": "IL12A binds IL12B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022141", "l": "Prolysyl oxidase activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357432", "l": "AXL binds SRC-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110319", "l": "Elongation by POLH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69152", "l": "Removal of remaining Flap (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835992", "l": "VTRNA2-1 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56115", "l": "2-all-trans-nonaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-nonaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40642", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050269", "l": "coniferyl-aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31636", "l": "beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O => 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23084", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6-enoyl-CoA + acetate", "d": [], "t": []}, {"i": "EC:4.1.3.26", "l": "\"3-hydroxy-3-isohexenylglutaryl-CoA lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050596", "l": "vinorine hydroxylase activity", "d": ["Catalysis of the reaction: H+ + NADPH + O2 + vinorine = H2O + NADP+ + vomilenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9670673", "l": "FIX is secreted (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418442", "l": "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954208", "l": "ERBB4s80:ESR1 binds PGR gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450827", "l": "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2. (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603407", "l": "Activated NTRK3 binds PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58233", "l": "L-seryl-[protein] + NAD(+) => H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34792", "l": "2-hydroxyethylphosphonate + O2 => formate + H(+) + hydroxymethylphosphonate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52876", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74099", "l": "ADP-L-glycero-beta-D-manno-heptose + L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli) = ADP + H(+) + L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5632677", "l": "PTCH is internalized (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9865412", "l": "TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67144", "l": "2-oxoglutarate + jasmonate + O2 = (1R,2R)-12-hydroxyjasmonate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917693", "l": "ESCRT Disassembly (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55379", "l": "2 a quinol + O2 <=> 2 a quinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9909159", "l": "HK1 phosphorylates Mannose to Man6P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34904", "l": "4 glutathione + 2 H(+) + selenite => glutathione disulfide + 3 H2O + selenodiglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26081", "l": "(2E,6E)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.40", "l": "\"(Z)-gamma-bisabolene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32967", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O = a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50514", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] => acetyl-CoA + N-terminal L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209087", "l": "IKBA is phosphorylated by Phospho IKKB kinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797100", "l": "CCNK binds CDK13 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37645", "l": "1-tetradecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109858", "l": "MAP2K2 binds MAPK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67945", "l": "2-hydroxyhexadecanoate + O2 => 2-oxohexadecanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951727", "l": "cAMP binds PKA tetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004622", "l": "lysophospholipase activity", "d": ["Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985594", "l": "MYO9B inactivates RHOA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018807", "l": "RAC3 GDIs block activation of RAC3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482825", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8869607", "l": "NMRK2 phosphorylates NAR to yield NAMN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65377", "l": "a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine in mRNA + 2 S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38293", "l": "(S)-malate + CoA + H(+) => (S)-malyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473596", "l": "Collagen type I degradation by MMP15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22224", "l": "3 H(+) + 3 malonyl-CoA + N-methylanthraniloyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O", "d": [], "t": []}, {"i": "EC:2.3.1.159", "l": "\"acridone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419003", "l": "Interaction of Nectins with Afadin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445699", "l": "ATP Hydrolysis By Myosin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53604", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56549", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391933", "l": "EP3 receptor can bind PGE2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69068", "l": "RFC dissociates after sliding clamp formation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607740", "l": "PKC-delta phosphorylates CARD9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.67", "l": "\"zingipain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938231", "l": "RUNX1:CBFB binds CREBBP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000137", "l": "CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018793", "l": "3,5-dibromo-4-hydroxybenzoate decarboxylase activity", "d": ["Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0051540", "l": "metal cluster binding", "d": ["Binding to a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044684", "l": "dihydromethanopterin reductase activity", "d": ["Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168459", "l": "Lyn activates ERK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901974", "l": "glycerate transmembrane transporter activity", "d": ["Enables the transfer of glycerate from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74300", "l": "D-isoleucine(out) + D-serine(in) => D-isoleucine(in) + D-serine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66719", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate <=> (2S)-3-sulfolactaldehyde + D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51796", "l": "deoxycohumulone + dimethylallyl diphosphate = colupulone + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16261", "l": "L-lysyl-[protein] + succinyl-CoA = CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045484", "l": "L-lysine 6-transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63087", "l": "chloride + FADH2 + ilicicolin B + O2 <=> FAD + H(+) + 2 H2O + ilicicolin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912379", "l": "Transport of fringe-modified NOTCH to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28004", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone => beta-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026008", "l": "Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73650", "l": "CTP(out) + IMP(in) <=> CTP(in) + IMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21922", "l": "Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP => di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944257", "l": "Association of procollagen type XXIV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51164", "l": "cytidine(61) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(61) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682863", "l": "RNF168 binds DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30729", "l": "dADP + H(+) + phosphoenolpyruvate => dATP + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.26", "l": "\"O-antigen ligase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109339", "l": "Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73490", "l": "a carboxylate(in) + orotate(out) <=> a carboxylate(out) + orotate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62776", "l": "4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56351", "l": "4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654623", "l": "Activated FGFR3 binds FRS3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813740", "l": "GDE1 hydrolyzes GroPIns (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71315", "l": "chloride(out) + L-serine(out) + 2 Na(+)(out) = chloride(in) + L-serine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21131", "l": "S-adenosyl-L-methionine + zymosterol <=> fecosterol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25436", "l": "(2E,6E)-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.38", "l": "\"alpha-bisabolene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61032", "l": "3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine = 5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77766", "l": "a 3'-end ribonucleotidyl-ribonucleotide-RNA + H2O <=> a 3'-end ribonucleotide-RNA + a ribonucleoside 5'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70834", "l": "L-arginine(in) + L-leucine(out) + Na(+)(out) <=> L-arginine(out) + L-leucine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25410", "l": "ADP + alpha,alpha-trehalose + H(+) => ADP-alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41765", "l": "a ganglioside GD3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GT3 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40762", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67227", "l": "(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA <=> (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72059", "l": "glycochenodeoxycholate(out) + 2 Na(+)(out) = glycochenodeoxycholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.99.1", "l": "\"triphosphate--protein phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73188", "l": "(R)-benzodiazepinedione + dimethylallyl diphosphate => (2R,3S,11R)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78394", "l": "D-mannose(out) <=> D-mannose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139970", "l": "FMO3:FAD N-oxidises TMA to TMAO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44105", "l": "decanal + H2O + NAD(+) => decanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008744", "l": "L-xylulokinase activity", "d": ["Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64802", "l": "(4S)-5,6-dihydro-4H-1,3-thiazine-4-carboxylate + 2 H(+) + NADH + NH4(+) => NAD(+) + S-(2-aminoethyl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874745", "l": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48773", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a => 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195418", "l": "NRP-2 associates with VEGFR1 forming complexes on  cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15699", "l": "2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase] => (2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948136", "l": "ULK1 Translocates to the mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41364", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58219", "l": "A + dihydroserpentine <=> AH2 + serpentine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139909", "l": "Translocation of BMF to mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686398", "l": "SPIDR binds BLM:TOP3A:RMI1:RMI2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23442", "l": "4-hydroxybenzoate + chloride + H(+) => 4-chlorobenzoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15665", "l": "aldehydo-D-glucose + L-lysyl-[protein] = H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32301", "l": "2 diphosphate + NAD(+) + squalene => 2 (2E,6E)-farnesyl diphosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199046", "l": "Ligands bind L-selectin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55961", "l": "4-(trimethylamino)butanoate + ATP + CoA => 4-(trimethylamino)butanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375138", "l": "CDO binds BOC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61920", "l": "(2R,4S)-ketoconazole(in) + ATP + H2O = (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26330", "l": "(8S)-8-amino-7-oxononanoate + L-lysine => (7R,8S)-7,8-diammoniononanoate + (S)-2-amino-6-oxohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9824986", "l": "XPO1-dependent export of p-S69,S73 MITF-M (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4086083", "l": "SUMOylation of ING2 with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29595", "l": "CoA + NADP(+) + sulfoacetaldehyde = H(+) + NADPH + sulfoacetyl-CoA", "d": [], "t": []}, {"i": "EC:1.2.1.81", "l": "\"sulfoacetaldehyde dehydrogenase (acylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57837", "l": "H2O + O2 + thermospermine => 3-aminopropanal + H2O2 + spermidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70481", "l": "TPI1 isomerizes GA3P to DHAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31665", "l": "L-glutamate + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => 2-oxoglutarate + UDP-N-acetylbacillosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66151", "l": "2-phenylethylamine + acetyl-CoA <=> CoA + H(+) + N-(2-phenylethyl)acetamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0031893", "l": "vasopressin receptor binding", "d": ["Binding to a vasopressin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55904", "l": "7-chloro-L-tryptophan + chloride + FADH2 + O2 = 6,7-dichloro-L-tryptophan + FAD + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.60", "l": "\"7-chloro-L-tryptophan 6-halogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65344", "l": "H(+) + oxidized [electron-transfer flavoprotein] + valproyl-CoA = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202394", "l": "Translocation of CARMA1 to Plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9761027", "l": "ZEB2 binds SP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047354", "l": "sphingosine cholinephosphotransferase activity", "d": ["Catalysis of the reaction: CDP-choline + sphingosine = CMP + H+ + sphingosyl-phosphocholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0050750", "l": "low-density lipoprotein particle receptor binding", "d": ["Binding to a low-density lipoprotein receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198270", "l": "PDPK1 phosphorylates AKT at T308 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3645780", "l": "TGFBR2 KD mutants do not phosphorylate TGFBR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52895", "l": "H2O + NADP(+) + nitrosobenzene <=> H(+) + NADPH + nitrobenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41568", "l": "aclacinomycin T + dTDP-2-deoxy-beta-L-fucose = aclacinomycin S + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029150", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202127", "l": "eNOS synthesizes NO (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032794", "l": "GTPase activating protein binding", "d": ["Binding to a GTPase activating protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64160", "l": "ATP + glycyl-[methyl-coenzyme M reductase] + hydrogen sulfide = ADP + phosphate + thioglycyl-[methyl-coenzyme M reductase]", "d": [], "t": []}, {"i": "EC:6.2.2.1", "l": "\"thioglycine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63772", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177937", "l": "Phosphorylation of EGFR by SRC kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34591", "l": "Co-precorrin-7 + S-adenosyl-L-methionine = Co-precorrin-8X + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.289", "l": "\"cobalt-precorrin-7 (C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70313", "l": "cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine => beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18227", "l": "6-aminohexanoate + [N-(6-aminohexanoyl)](n-1) => [N-(6-aminohexanoyl)](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18181", "l": "acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.9", "l": "\"malate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19495", "l": "alpha-D-glucose 1-phosphate + D-glucose => D-cellobiose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47434", "l": "(2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein] => (7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222237", "l": "SMYD2 methylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29732", "l": "beta-maltose(in) => beta-maltose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45970", "l": "9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+) => androst-4-ene-3,17-dione + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72056", "l": "glycodeoxycholate(out) + 2 Na(+)(out) => glycodeoxycholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810392", "l": "TMEM55B translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41648", "l": "aniline + ATP + L-glutamate = ADP + N(5)-phenyl-L-glutamine + phosphate", "d": [], "t": []}, {"i": "EC:6.3.1.18", "l": "\"gamma-glutamylanilide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938887", "l": "PML binds RUNX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161187", "l": "ADAL1 hydrolyzes N6-methyl-AMP to IMP and methylamine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52169", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 8,9-epoxy-(5Z,11Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71775", "l": "SUCLG1/G2 cleaves succinyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964252", "l": "G alpha (s):GTP:SRC catalyzes SRC to p-Y419-SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033476", "l": "Dimerization of FGFR3 point mutants with enhanced kinase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32166", "l": "ATP + citrate + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> AMP + diphosphate + H(+) + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14879", "l": "ADP + L-glutamyl 5-phosphate => ATP + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51546", "l": "D-xylulose => D-ribulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57701", "l": "a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + 3 H(+) + L-methionine + oxidized [flavodoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982792", "l": "Growth hormone receptor binds JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67465", "l": "H2O + propanoyl-CoA => adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39473", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP(+) => (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21595", "l": "(2S)-2-[(R)-1-carboxyethylamino]pentanoate + H2O + NAD(+) <=> H(+) + L-2-aminopentanoate + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805109", "l": "CDK2 phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218832", "l": "CDC42:GTP binds PAK2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836702", "l": "PKR inhibitors bind PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5225649", "l": "RBBP7 binds histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696491", "l": "CNTF binds CNTFR complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733964", "l": "SLC51A:SLC51B transports bile salts from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46878", "l": "[(1->4)-beta-D-mannuronosyl](n+1) + GDP + H(+) => [(1->4)-beta-D-mannuronosyl](n) + GDP-alpha-D-mannuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38238", "l": "(9Z)-octadecenoyl-CoA + octadecan-1-ol <=> 1-O-octadecyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004454", "l": "ketohexokinase activity", "d": ["Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341294", "l": "Superoxide reduces cytochrome c (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805811", "l": "Release of SEPT4 from mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047738", "l": "cellobiose phosphorylase activity", "d": ["Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939900", "l": "RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112396", "l": "Separation of elongating transcript from template (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55948", "l": "A + D-alanine + H2O = AH2 + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047069", "l": "7,8-dihydroxykynurenate 8,8a-dioxygenase activity", "d": ["Catalysis of the reaction: 7,8-dihydroxykynurenate + O2 = 5-(3-carboxylato-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22868", "l": "3-chloro-L-alanine + thioglycolate = chloride + H(+) + S-carboxymethyl-L-cysteine", "d": [], "t": []}, {"i": "EC:4.5.1.5", "l": "\"S-carboxymethylcysteine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58527", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH <=> (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.7", "l": "\"chaperonin ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-947535", "l": "Cyclisation of GTP to precursor Z (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73472", "l": "D-ornithine(in) + L-ornithine(out) => D-ornithine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70924", "l": "(R)-noradrenaline(out) + chloride(out) + Na(+)(out) => (R)-noradrenaline(in) + chloride(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15388", "l": "L-asparagine <=> 3-cyano-L-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483107", "l": "GPETA is hydrolyzed to ETA and G3P by GPCPD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199456", "l": "PTEN dephosphorylates PIP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43961", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA => a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205136", "l": "GTP-bound RAC contributes to JNK activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187934", "l": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50119", "l": "eicosanoyl-CoA + taurine <=> CoA + H(+) + N-eicosanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61390", "l": "ADP + biotin(out) + H(+) + phosphate => ATP + biotin(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855200", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9681616", "l": "AP2 binds chlorpromazine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64001", "l": "(4R)-hydroxysphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050565", "l": "aerobactin synthase activity", "d": ["Catalysis of the reaction: ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine = aerobactin + AMP + diphosphate + H+."], "t": []}, {"i": "RHEA:32167", "l": "ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine = aerobactin + AMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.2.39", "l": "\"aerobactin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731931", "l": "EDNRA binds selective ERAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2428926", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20247", "l": "3''-O-adenylylstreptomycin + diphosphate => ATP + streptomycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72152", "l": "estrone 3-sulfate(out) + glutarate(in) => estrone 3-sulfate(in) + glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65317", "l": "2-oxoglutarate + chrodrimanin H + O2 => chrodrimanin E + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36698", "l": "dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid <=> desmethyldescarbamoylnovobiocin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788867", "l": "FN3K phosphorylates ketosamines (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218642", "l": "PTK2 autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201476", "l": "Activated type I receptor phosphorylates R-Smad1/5/8 directly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851225", "l": "NTPDase4 hydrolyzes nucleoside diphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003871", "l": "5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797961", "l": "CHDH oxidises Cho to BETALD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76363", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(out) = n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30281", "l": "3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52235", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + Fe(2+) + 3 H2O + mycobilin a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65667", "l": "citrate(out) + 4 Na(+)(out) <=> citrate(in) + 4 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43127", "l": "guanosine(10) in tRNA + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.3.5", "l": "\"prenylcysteine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9865412", "l": "TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028583", "l": "Phosphorylation of YAP by LATS2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72813", "l": "L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out) => L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22319", "l": "13-hydroxydocosanoate + UDP-alpha-D-glucose <=> 13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36953", "l": "(9Z)-heptadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + heptadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14071", "l": "5-dehydro-D-fructose + H(+) + NADPH => D-fructose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952081", "l": "RUNX proteins bind the p14-ARF promoter at the CDKN2A locus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74320", "l": "O-acetyl-(R)-carnitine(in) => O-acetyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65121", "l": "H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione => L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013024", "l": "RHOB binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.118", "l": "\"kallikrein 8\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54417", "l": "5alpha-campestan-3-one + NADP(+) => campest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102853", "l": "1-18:1-2-18:1-sn-glycerol-3-phosphocholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:2-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56145", "l": "a quinol + nitrate => a quinone + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29993", "l": "H(+)(out) + L-lyxopyranose(out) => H(+)(in) + L-lyxopyranose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49616", "l": "2-hydroxy-2-methylpropanal + H2O + NAD(+) = 2-hydroxy-2-methylpropanoate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.98", "l": "\"2-hydroxy-2-methylpropanal dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592436", "l": "Initial activation of proMMP9 by MMPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45378", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + sphinganine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38248", "l": "(9Z)-hexadecenoyl-CoA + hexadecan-1-ol => 1-O-hexadecyl (9Z)-hexadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69400", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51310", "l": "H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) => H(+) + L-methionyl-[F-actin] + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265682", "l": "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55209", "l": "(4R)-hydroxysphinganine 1-phosphate => (2R)-hydroxyhexadecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55586", "l": "an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine => an adenosine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29381", "l": "2'-deoxyguanosine + phosphate => dGMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193665", "l": "MYD88 dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33558", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H2O <=> (4R)-hydroxysphinganine + a fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250315", "l": "Trans-autophosphorylation of ERBB4 homodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3247839", "l": "Retromer associates with WLS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37636", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45014", "l": "(4R)-hydroxysphinganine + octadecanoate => H2O + N-octadecanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17700", "l": "pyridine + thiamine <=> 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800490", "l": "ATM phosphorylates PIDD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2471842", "l": "Collagen type XXV ectomain shedding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102028", "l": "cystathionine gamma-synthase activity (acts on O-phosphohomoserine)", "d": ["Catalysis of the reaction: L-cysteine + O-phosphonato-L-homoserine = L-cystathionine + hydrogenphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63864", "l": "O2 + octadecanoate = (2R)-2-hydroperoxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13141", "l": "2-methylpropanoyl-CoA = butanoyl-CoA", "d": [], "t": []}, {"i": "EC:5.4.99.13", "l": "\"isobutyryl-CoA mutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390929", "l": "HTR1 and 5A receptors can bind serotonin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54223", "l": "1-hydroxy-all-trans-1,2-dihydro-neurosporene <=> all-trans-neurosporene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016707", "l": "gibberellin 3-beta-dioxygenase activity", "d": ["Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0051424", "l": "corticotropin-releasing hormone binding", "d": ["Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39639", "l": "(3R)-hydroxy-(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA = (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-398040", "l": "Gbeta:gamma activation of PLC beta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37754", "l": "2-methyl-trans-aconitate <=> 2-methyl-cis-aconitate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211734", "l": "Ubiquitination of PAK-2p34 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22149", "l": "a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin] => a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043337", "l": "cardiolipin synthase (CMP-forming)", "d": ["Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28059", "l": "L-lyxopyranose => L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849748", "l": "The COG complex binds RABs at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39320", "l": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH => (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2203480", "l": "COLEC11 binds ligands (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15896", "l": "Co-sirohydrochlorin + 2 H(+) <=> Co(2+) + sirohydrochlorin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46153", "l": "15-cis-phytoene + a plastoquinone => 15,9'-di-cis-phytofluene + a plastoquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66248", "l": "CoA + IC-asc-C9-AMP = AMP + H(+) + IC-asc-C9-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029458", "l": "Recruitment of VAV1 to p-6Y-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296126", "l": "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448673", "l": "Formation of caspase-1 p10/p20 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216045", "l": "Collagen type I binds integrin alpha11beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19869", "l": "an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.13", "l": "\"glycine N-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694427", "l": "MIA3 binds procollagen VII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17434", "l": "A + choline => AH2 + betaine aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201515", "l": "Active ALK recruits PI3K (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60086", "l": "a 4alpha-methyl-3-oxosteroid + CO2 + NADH => a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28747", "l": "NH4(+)(in) = NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52629", "l": "an N-fatty-acyl-L-alpha-amino acid + H2O => a fatty acid + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32258", "l": "meso-2,6-diaminoheptanedioate + NADP(+) <=> (S)-2,3,4,5-tetrahydrodipicolinate + 2 H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163310", "l": "TFAM binds to mitochondrial promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.5.3", "l": "\"formate dehydrogenase-N\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36020", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22207", "l": "3-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981621", "l": "C3 convertases spontaneously dissociate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53307", "l": "AH2 + 2 ATP + 2 cob(II)alamin <=> A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372819", "l": "PCK2 phosphorylates OA to yield PEP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167284", "l": "7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13814", "l": "benzene + H(+) + NADH + O2 => cis-1,2-dihydrobenzene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675198", "l": "Activated MAPKs phosphorylate BRAF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78151", "l": "a 3-acyl-sn-glycerol + H2O = a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65730", "l": "CO2 + H(+) + hexanal + succinate + sulfate => 2-oxoglutarate + hexyl sulfate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74833", "l": "UDP-alpha-D-glucuronate(in) + UDP-alpha-D-xylose(out) => UDP-alpha-D-glucuronate(out) + UDP-alpha-D-xylose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9823906", "l": "TBK1 is phosphorylated within the activated TLR4 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038174", "l": "interleukin-17A receptor activity", "d": ["Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67642", "l": "ADP + dZDP => ATP + dZMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682010", "l": "ATG10:ATG12 binds ATG5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39287", "l": "Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine = dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein]", "d": [], "t": []}, {"i": "EC:2.1.1.250", "l": "\"[trimethylamine--corrinoid protein] Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20368", "l": "phosphoethanolamine + S-adenosyl-L-methionine <=> H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57198", "l": "glycolate + H(+) + L-cysteinyl-[protein] => H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879222", "l": "MDP:NLRP1 binds ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23878", "l": "H2O + xanthoaphin => protoaphin aglucone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629888", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670673", "l": "FIX is secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65970", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate => 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372819", "l": "PCK2 phosphorylates OA to yield PEP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032561", "l": "guanyl ribonucleotide binding", "d": ["Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59411", "l": "H2O + N-acetyl-L-aspartate <=> acetate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352347", "l": "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.40", "l": "\"phytepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850786", "l": "SPINK6 binds KLK12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0070524", "l": "11-beta-hydroxysteroid dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20309", "l": "2 H2O2 = 2 H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607740", "l": "PKC-delta phosphorylates CARD9 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047562", "l": "3-hydroxyaspartate aldolase activity", "d": ["Catalysis of the reaction: (3R)-3-hydroxy-L-aspartate = glycine + glyoxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102135", "l": "(22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 = (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22246", "l": "H(+) + kaempferol 3-O-beta-D-xyloside + UDP => kaempferol + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047471", "l": "maltose alpha-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: maltose = trehalose."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33421", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48912", "l": "a ganglioside GD1a + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1a + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0019798", "l": "procollagen-proline dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534160", "l": "HSPG2 (perlecan) degradation by MMP13, CTSS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840795", "l": "Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173740", "l": "Factor B binds to C3(H2O) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022381", "l": "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737710", "l": "SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785478", "l": "Processed tRNA binds XPOT and RAN:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22675", "l": "2 (2E,6E)-farnesyl diphosphate <=> diphosphate + presqualene diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983427", "l": "Expression of peptide bound class I MHC on cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70458", "l": "(6S)-5,6,7,8-tetrahydrofolate + O2 + sarcosine <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944240", "l": "Association of procollagen type III (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14716", "l": "A + keto-L-sorbose <=> 5-dehydro-D-fructose + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686315", "l": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810724", "l": "PI3 binds the bacterial surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785342", "l": "FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75921", "l": "dihydroxyacetone + H(+) + NADPH + NH4(+) => H2O + NADP(+) + serinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37785", "l": "1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190245", "l": "FGFR1b binds to FGF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029465", "l": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23029", "l": "malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein] => acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53761", "l": "allocholate + deoxycholoyl-CoA => allocholoyl-CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55769", "l": "all-trans-retinoate + UDP-alpha-D-glucuronate => all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54155", "l": "a uridine in rRNA + S-adenosyl-L-methionine <=> a 2'-O-methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31939", "l": "2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase] = DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.110", "l": "\"2-hydroxy-1,4-benzoxazin-3-one monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2404200", "l": "IGF1,2 binds IGF1R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204850", "l": "Interaction of Tie2 and Dok-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388830", "l": "PI3K binds ICOS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12793", "l": "1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49985", "l": "H(+) + jasmonate + NADPH + O2 => (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021601", "l": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34475", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.32", "l": "\"15-cis-phytoene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64378", "l": "a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2 => 8 A + a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68400", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + gamma-gurjunene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37882", "l": "methyl aklanonate <=> aklaviketone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49569", "l": "2-glutathionyl-2-methylbut-3-en-1-ol => (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848087", "l": "STAP2 recruits STAT3 to PTK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805573", "l": "Keratin type I/type II heterodimers form tetramers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034324", "l": "O-hexanoyltransferase activity", "d": ["Catalysis of the transfer of a hexyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50098", "l": "13-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174202", "l": "Degradation of multiubiquitinated Securin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68428", "l": "lutein + O2 = (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R,6R)-hydroxy-alpha-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61121", "l": "kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69063", "l": "Loading of PCNA - Sliding Clamp Formation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682769", "l": "LGI2 binds ADAM22,23 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-167415", "l": "G-protein alpha subunit is inactivated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14570", "l": "propane-1,2-diol => H2O + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57717", "l": "hydrogencarbonate + NH4(+) => carbamate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48929", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425861", "l": "Activation of Protein Kinase C novel isoforms (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69437", "l": "7-oxopregnenolone + H(+) + NADPH => 7beta-hydroxypregnenolone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70813", "l": "D-xylulose 5-phosphate + sulfoacetaldehyde => 4-deoxy-4-sulfo-D-erythrulose + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50592", "l": "13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432164", "l": "Ca2+ influx into the post-synaptic cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49913", "l": "(R)-carnitine(out) + O-propanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-propanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68554", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11189", "l": "3-cyano-L-alanine + 2 H2O => L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800793", "l": "PIDD1 translocates to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21851", "l": "(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide <=> (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647746", "l": "EML4 trimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202212", "l": "Recruitment of PLC-gamma1 to LAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31918", "l": "ATP + D-maltose <=> ADP + alpha-maltose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647645", "l": "GSDMD oligomerizes into arc-, slit-shaped structures (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676141", "l": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68398", "l": "a carboxylate + H(+) + H2O2 => a percarboxylic acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14408", "l": "D-glucose + NADP(+) <=> D-glucono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21502", "l": "H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose => UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62660", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol = (2'R)-atrovenetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210273", "l": "Interaction of DAP12 and NKp44 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.147", "l": "\"thioglucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047988", "l": "hydroxyacid-oxoacid transhydrogenase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69368", "l": "11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) = 17beta-hydroxyandrost-4-ene-3,11-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14749", "l": "1-hydroxy-2-naphthoate + O2 = (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.38", "l": "\"1-hydroxy-2-naphthoate 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852200", "l": "Inactivation of LCK by PTPN22 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420131", "l": "The PACAP receptor binds PACAP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27618", "l": "(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate = di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015545", "l": "bicyclomycin transmembrane transporter activity", "d": ["Enables the transfer of bicyclomycin from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70745", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67523", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43595", "l": "all-trans-zeaxanthin + O2 <=> (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661419", "l": "ALB binds extracellular heme (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.73", "l": "\"lipopolysaccharide glucosyltransferase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74157", "l": "formaldehyde + glycine + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => H2O + oxidized 2[4Fe-4S]-[ferredoxin] + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867041", "l": "EGFR phosphorylates EPS15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49574", "l": "coproporphyrin III + Fe(2+) => Fe-coproporphyrin III + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71858", "l": "taurochenodeoxycholate(out) <=> taurochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44461", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol => a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72739", "l": "chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) = chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60034", "l": "8-oxo-GDP + H(+) + phosphate => 8-oxo-GTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17058", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62011", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66312", "l": "an alpha-mannosylinositol-1-phosphoceramide + H2O = a D-mannosyl-alpha-1->6-inositol-1-phosphate + an N-acyl-sphingoid base + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41041", "l": "1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27866", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O = (R)-glycerate + alpha-D-mannose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663156", "l": "p-BMAL1:p-CLOCK,NPAS2 binds PPARA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6786650", "l": "DDHD1,2 hydrolyse PA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40383", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446200", "l": "DOLPP1 dephosphorylates DOLDP to DOLP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60223", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(4)-[histone H3] + O2 <=> CO2 + formaldehyde + L-lysyl(4)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "50.080991861558424", "identifiers": [{"i": "GO:0022832", "l": "voltage-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975103", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814096", "l": "ARL1:GTP binds SCOC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615839", "l": "PIAS1 SUMOylates SATB1 with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12338", "l": "fumarate + glycolate => carboxymethoxysuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28209", "l": "2'-deoxyuridine + ATP <=> ADP + dUMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55562", "l": "a hydroxy-epoxy-eicosatetraenoate => a hydroperoxyeicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62621", "l": "[thioredoxin]-dithiol + a hydroperoxide => [thioredoxin]-disulfide + an alcohol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78087", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072346", "l": "cADPR-sensitive calcium-release channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-167433", "l": "G-protein beta-gamma subunits rebind the alpha-GDP subunit (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665998", "l": "MKL1 binds SRF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15010", "l": "(6S)-5,6,7,8-tetrahydrofolate + NADP(+) => 7,8-dihydrofolate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43596", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 = 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070976", "l": "TIR domain binding", "d": ["Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731075", "l": "Syndecan-1 binds collagen types I, III, V (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32332", "l": "(1S,2S,4R)-endo-fenchol + NAD(+) => (1S,4R)-fenchone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149519", "l": "MMACHC decyanates CNCbl (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388468", "l": "AVP(20-28) binds AVPR1A,B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982640", "l": "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22455", "l": "[phosphate](n+1) + n H2O <=> n H(+) + (n+1) phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786166", "l": "Translesion synthesis across unhooked ICL by POLN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210289", "l": "Recruitment of SYK to p-DAP12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60944", "l": "quercetin + S-adenosyl-L-methionine = H(+) + isorhamnetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193702", "l": "Part of the ICD migrates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444620", "l": "Neuropeptide S receptor binds neuropeptide S (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018867", "l": "5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42235", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090584", "l": "protein-phosphocysteine-galactitol-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + galactitol(out) = protein cysteine + galactitol-6-phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5225602", "l": "WDR5 binds Me2sR3-replicative histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16526", "l": "2-dehydro-3-deoxy-D-galactonate + ATP => 2-dehydro-3-deoxy-6-phospho-D-galactonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36788", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188386", "l": "Association of Rb with Cyclin E:Cdk2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22297", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate => (1R,2R,3R)-prephytoene diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36838", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043885", "l": "carbon-monoxide dehydrogenase (ferredoxin) activity", "d": ["Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60703", "l": "a 1-acyl-sn-glycero-3-phosphocholine <=> a 1-acyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77960", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol => a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8981353", "l": "RASA1 stimulates RAS GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9842671", "l": "Active LTK binds IRS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59669", "l": "D-cellohexaose + O2 => D-cellohexaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265425", "l": "Interaction of integrin alphaVbeta3 with von Willbrand Factor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265296", "l": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52659", "l": "a long-chain (3S)-3-hydroxy fatty acyl-CoA + NAD(+) <=> a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33276", "l": "a 1,2-diacyl-sn-glycerol + H2O => a 2-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21463", "l": "benzoin <=> 2 benzaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.-", "l": "\"Other lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210295", "l": "Interaction of DAP12 and NKG2D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008805", "l": "carbon-monoxide oxygenase activity", "d": ["Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15100", "l": "5-formimidoyltetrahydrofolate + L-glutamate <=> (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72215", "l": "2 hydrogencarbonate(out) + Na(+)(out) = 2 hydrogencarbonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38871", "l": "uridine(2457) in 23S rRNA = pseudouridine(2457) in 23S rRNA", "d": [], "t": []}, {"i": "EC:5.4.99.20", "l": "\"23S rRNA pseudouridine(2457) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35503", "l": "11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = 30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58472", "l": "2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + O2 = CO2 + formaldehyde + N(omega)-methyl-L-arginyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802930", "l": "Dimerization of BRAF V600E splice variants contributes to BRAF inhibitor resistance (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944454", "l": "mTORC1 phosphorylates MAF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.122", "l": "\"(S)-tetrahydroprotoberberine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73178", "l": "ADP(in) + FMN(out) <=> ADP(out) + FMN(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102646", "l": "14betaH-scalarane-17alpha-19-diol synthase activity", "d": ["Catalysis of the reaction: 14betaH-scalarane-17alpha-19-diol = all-trans-geranylfarnesol + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203567", "l": "palmitoylation of eNOS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61343", "l": "(S)-methylmalonyl-CoA + H(+) <=> CO2 + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12837", "l": "ATP + choline = ADP + H(+) + phosphocholine", "d": [], "t": []}, {"i": "EC:2.7.1.32", "l": "\"choline kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23409", "l": "NADP(+) + precorrin-6B => 2 H(+) + NADPH + precorrin-6A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032035", "l": "myosin II tail binding", "d": ["Binding to the tail region of a myosin II heavy chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57515", "l": "chlorobenzene + H(+) + NADH + O2 <=> (1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29589", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH => 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34814", "l": "NADP(+) + tetrahydrocurcumin <=> dihydrocurcumin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25857", "l": "(9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018604", "l": "4-aminobenzoate 3,4-dioxygenase (deaminating) activity", "d": ["Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874218", "l": "CREB3L4 translocates from the cytosol to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9838035", "l": "CLPXP binds mitochondrial matrix proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21166", "l": "a carboxylate + an alcohol + H(+) => a carboxylic ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1008200", "l": "NFE2 binds the beta globin locus control region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10603", "l": "prostaglandin H2 <=> prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46167", "l": "a quinone + H(+) + NADPH <=> a quinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43153", "l": "adenosine(58) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694462", "l": "ABHD6,12 hydrolyse 3AG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371467", "l": "SIRT1 deacetylates HSF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25989", "l": "(5R)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382056", "l": "Crk binds to the active PDGF receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14573", "l": "D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.40", "l": "\"glucarate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640321", "l": "2,3-DKG hydrolyses to ERU and oxalate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60930", "l": "17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9650165", "l": "ASIC trimers bind H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9725855", "l": "NR3C2 binds NR3C2 antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190519", "l": "Internalization of gap junction plaques (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702849", "l": "CALCR binds gepants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60087", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72492", "l": "citrate(out) + maleate(in) => citrate(in) + maleate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33556", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H2O => (4R)-hydroxysphinganine + a fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70210", "l": "sphinga-4E,14Z-dienine-1-phosphate(in) <=> sphinga-4E,14Z-dienine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3204311", "l": "AOX1 oxidises PXL to PDXate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0070279", "l": "vitamin B6 binding", "d": ["Binding to a vitamin B6 compound: pyridoxal, pyridoxamine, pyridoxine, or the active form, pyridoxal phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806974", "l": "MET dimers autophosphorylate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49886", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419255", "l": "5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48110", "l": "2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine => L-arginyl-[protein] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592242", "l": "Expression of NRF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77866", "l": "(2S)-3-phenyl-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O <=> 2-dehydro-D-glucose + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56858", "l": "a carboxylate + AH2 + H(+) => A + an aldehyde + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4167511", "l": "HLCS biotinylates ACACB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676264", "l": "Formation of the SET1B complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106302", "l": "arachidonic acid 8,9-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-8,9-epoxyeicosatrienoic acid."], "t": []}, {"i": "RHEA:64984", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606839", "l": "ARSC hydrolyzes steroid sulfates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442749", "l": "CaMKK autophosphorylates in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63508", "l": "a 1,2-saturated fatty acid + O2 = a (2R)-2-hydroperoxy fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033491", "l": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23418", "l": "(2R)-3-sulfolactate + phosphate => (2R)-O-phospho-3-sulfolactate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872463", "l": "SLC9C1 exchanges Na+ for H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71916", "l": "2 Na(+)(out) + tauronorcholate(out) => 2 Na(+)(in) + tauronorcholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17326", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA => (S)-2-succinylamino-6-oxoheptanedioate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102308", "l": "erythromycin D 3''-o-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin D = S-adenosyl-L-homocysteine + erythromycin B + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38151", "l": "carbonyl sulfide + H2O = CO2 + H(+) + hydrogen sulfide", "d": [], "t": []}, {"i": "EC:3.13.1.7", "l": "\"carbonyl sulfide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68830", "l": "camphor + H(+) + NADH => borneol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.3", "l": "\"protoporphyrinogen IX dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25915", "l": "A + H2O + quinolin-5-ol <=> 5-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31646", "l": "mycinamicin VI + S-adenosyl-L-methionine <=> H(+) + mycinamicin III + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40342", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70530", "l": "H(+) + N-acyl-3-oxosphinganine + NADH <=> an N-acylsphinganine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002173", "l": "low-affinity IgM receptor activity", "d": ["Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202222", "l": "Phosphorylation of PKC theta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202325", "l": "Recruitment of Gads to LAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60202", "l": "2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25683", "l": "L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10697", "l": "a long-chain fatty acid + ATP + holo-[mycocerosate synthase] => AMP + diphosphate + long-chain fatty acyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0043211", "l": "ABC-type carbohydrate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of carbohydrates across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46341", "l": "ATP + N-hexadecanoylsphing-4-enine => ADP + H(+) + N-(hexadecanoyl)-sphing-4-enine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69374", "l": "2-oxohexanoate + H2O2 => 2-hydroxyhexanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19462", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031473", "l": "myosin III binding", "d": ["Binding to a class III myosin; myosin III is monomeric and has an N terminal kinase domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23178", "l": "acetyl-CoA + AMP + diphosphate => acetate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689544", "l": "UCHL5 binds INO80 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110141", "l": "(d)ADP + ADP <=> (d)AMP + ATP (AK1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693609", "l": "ATM phosphorylates TP53 at S15 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9605644", "l": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791302", "l": "TP53 binds the AIFM2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67498", "l": "3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end CoA-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6807872", "l": "Active ARF recruits coatomer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75765", "l": "10-hydroxy-(11E)-octadecenoate => (9E,11E)-octadecadienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428690", "l": "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964614", "l": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57814", "l": "3-chlorocatechol + NAD(+) + nitrite => 1-chloro-2-nitrobenzene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44894", "l": "an N-(2-hydroxyacyl)-beta-D-galactosyl-sphinganine + H(+) + UDP => an N-(2-hydroxyacyl)-sphinganine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11545", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine => H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27315", "l": "dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 => 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102869", "l": "6-hydroxyflavone-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 6-hydroxyflavone = 6-O-beta-D-glucosyl-6-hydroxyflavone + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626938", "l": "Beta-catenin binds SOX proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42490", "l": "3'-N-debenzoyl-2'-deoxytaxol + CoA => (3R)-3-amino-3-phenylpropanoyl-CoA + baccatin III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51882", "l": "(2Z,4E)-2,3,5-trichloromuconate + H(+) => 3,4,6-trichlorocatechol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213208", "l": "Type X collagen associates with collagen type II fibrils (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23798", "l": "acetate + H(+) + norajmaline => 17-O-acetylnorajmaline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804879", "l": "MDM2 ubiquitinates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51889", "l": "2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) => 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052714", "l": "mannosyl-inositol phosphorylceramide phospholipase activity", "d": ["Catalysis of the reaction: mannosyl-inositol phosphorylceramide + H2O = C26-phytoceramide + mannosylphosphorylinositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-984733", "l": "Kinesin-3 is a dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70681", "l": "glycine betaine(out) + H(+)(out) => glycine betaine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22260", "l": "H2O + triacetate lactone = H(+) + triacetate", "d": [], "t": []}, {"i": "EC:3.1.1.38", "l": "\"triacetate-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0030519", "l": "snoRNP binding", "d": ["Binding to a small nucleolar ribonucleoprotein particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49019", "l": "aurachin C epoxide <=> 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-349657", "l": "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109858", "l": "MAP2K2 binds MAPK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25927", "l": "A + H2O + quinolin-8-ol <=> 8-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654428", "l": "Activated FGFR4 phosphorylates SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51653", "l": "D-mannonate + NAD(+) => H(+) + keto-D-tagaturonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38664", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) => a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706340", "l": "Active FLT3:p-Y-GRB10 binds PIK3R1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72344", "l": "3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46391", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S,25R)-24,26-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951500", "l": "Dissociation of CANX from nonameric complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-447074", "l": "AMPK phosphorylates Raptor in the mTORC1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70112", "l": "6-deoxo-28-norteasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 28-norteasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75964", "l": "15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione => 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62662", "l": "(2'R)-atrovenetin => 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18336", "l": "ATP + oleandomycin <=> ADP + H(+) + oleandomycin 2'-O-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604763", "l": "Autocatalytic activation of MMP7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.1.3", "l": "\"sirohydrochlorin cobaltochelatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8871265", "l": "YAP1 binds TEAD4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.6", "l": "\"4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954117", "l": "E2F6:TFDP1 binds EPC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9824994", "l": "RPS6KA1-dependent phosphorylation of MITF-M (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047465", "l": "N-acylglucosamine-6-phosphate 2-epimerase activity", "d": ["Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24070", "l": "H2O + hexano-6-lactone + NADP(+) => cyclohexanone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375340", "l": "Connexin 62 mediated neuronal gap junction communication (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43714", "l": "diphosphate + dodecanoyl-AMP => ATP + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192056", "l": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202394", "l": "Translocation of CARMA1 to Plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70411", "l": "4-hydroxyphenylacetyl-CoA + H2O = 4-hydroxyphenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693061", "l": "STAMBP binds STAM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56301", "l": "[thioredoxin]-dithiol + S-sulfanyl-L-cysteinyl-[protein] => [thioredoxin]-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380949", "l": "AMPK is dephosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8962039", "l": "TK1 gene expression is stimulated by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28368", "l": "beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30609", "l": "AH2 + all-trans-zeta-carotene => A + all-trans-phytofluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-965079", "l": "2xPNPO:2xFMN oxidizes PXAP to PXLP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847968", "l": "PTEN binds FRK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26476", "l": "alpha-D-galactose 1-phosphate + L-rhamnopyranose => beta-D-galactosyl-(1->4)-L-rhamnose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15939", "l": "an aldehyde + H(+) + NADPH => a primary alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102081", "l": "homotaurine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: homotaurine + 2-oxoglutarate(2-) = 3-sulfopropanal + L-glutamate(1-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40731", "l": "(20S)-ginsenoside Rg3 + 2 H2O = (20S)-protopanaxadiol + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.58", "l": "\"8-oxo-dGDP phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102219", "l": "phosphogluco-amylopectin water dikinase activity", "d": ["Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-amylopectin = n AMP + n hydrogenphosphate + a 6-phosphogluco-3-phosphogluco-amylopectin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018661", "l": "orcinol 2-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + orcinol = 2,3,5-trihydroxytoluene + H2O + NAD+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483087", "l": "PI is exchanged with PC by PITPNB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9860290", "l": "TASL recruits IRF5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78247", "l": "D-tryptophan + H2O + O2 = H2O2 + indole-3-pyruvate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3215448", "l": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030272", "l": "5-formyltetrahydrofolate cyclo-ligase activity", "d": ["Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2870221", "l": "E-selectin binds E-selectin ligand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47369", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + GDP-alpha-D-mannose => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38996", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O => a 1-acyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0050174", "l": "phenylalanine decarboxylase activity", "d": ["Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68817", "l": "(2Z,6E)-farnesyl diphosphate => (E)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73293", "l": "H(+)(in) + L-valine(out) => H(+)(out) + L-valine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000310", "l": "AURKA phosphorylates PLK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74269", "l": "n H(+)(in) + spermidine(out) => n H(+)(out) + spermidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28440", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675790", "l": "MTORC1 dissociates from ULK complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12605", "l": "D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2", "d": [], "t": []}, {"i": "EC:2.2.1.7", "l": "\"1-deoxy-D-xylulose-5-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34675", "l": "CTP + N,N-diacetyllegionaminate = CMP-N,N-diacetyllegionaminate + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.82", "l": "\"CMP-N,N'-diacetyllegionaminic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53459", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53871", "l": "2 H(+) + NADH + O2 + phenazine-1-carboxylate <=> 1-hydroxyphenazine + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858489", "l": "ppDVL binds DAAM1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158481", "l": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45778", "l": "(indol-3-yl)acetate + NH4(+) => (indol-3-yl)acetonitrile + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59501", "l": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373741", "l": "SDK2 homophillic interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58092", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11541", "l": "an N-acyl-D-mannosamine + NAD(+) => an N-acyl-D-mannosaminolactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42552", "l": "uridine(31) in tRNA = pseudouridine(31) in tRNA", "d": [], "t": []}, {"i": "EC:5.4.99.42", "l": "\"tRNA pseudouridine(31) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25627", "l": "H2O2 + imidazole-4-acetaldehyde + NH4(+) => H2O + histamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297333", "l": "Association of Acrosin Heavy and Light Chain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50290", "l": "(8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate => (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417820", "l": "P2Y9 receptor can bind to LPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44276", "l": "eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36409", "l": "diphosphate + H2O + L-threonylcarbamoyladenylate => ATP + hydrogencarbonate + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47973", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102334", "l": "N,N'-diacetylbacilliosaminyl-1-phosphate transferase activity", "d": ["Catalysis of the reaction: ditrans,polycis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine = N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928656", "l": "gamma-secretase cleaves EPHB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8959798", "l": "SLC30A10 transports Mn2+ from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45309", "l": "H(+) + NADPH + prostaglandin D2-ethanolamide => 11beta-prostaglandin F2-ethanolamide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625749", "l": "FOXO1,FOXO3 and SMAD3 bind TRIM63 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111238", "l": "Formation of ADAR2  homodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47801", "l": "4-methylsulfanyl-2-oxobutanoate + an aromatic L-alpha-amino acid => an aromatic oxo-acid + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62143", "l": "dTMP + GTP <=> dTDP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43898", "l": "3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11398", "l": "5-methyldeoxycytidine diphosphate + ADP => 5-methyldeoxycytidine 5'-phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31807", "l": "(2E,6E)-farnesyl diphosphate = alpha-guaiene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.87", "l": "\"alpha-guaiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-990489", "l": "Kinesin-13 is a dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482695", "l": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928631", "l": "GIT1 binds bPIX (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948136", "l": "ULK1 Translocates to the mitochondria (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.25", "l": "\"tRNA-uridine aminocarboxypropyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667619", "l": "AVPR1A,B,2 bind atosiban (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879222", "l": "MDP:NLRP1 binds ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23971", "l": "(E)-coniferaldehyde + H2O + NAD(+) <=> (E)-ferulate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672011", "l": "p-AMPK:AMP binds the ULK complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904841", "l": "TORC2 complex binding", "d": ["Binding to a TORC2 complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9661432", "l": "BIL binds ALB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433415", "l": "Activation of RAC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209921", "l": "Monoiodinated tyrosine can be deiodinated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12090", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP => an N-acylsphing-4-enine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0002162", "l": "dystroglycan binding", "d": ["Binding to dystroglycan, a glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77190", "l": "beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose <=> beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23501", "l": "H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) => 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11752", "l": "acetylsalicylate + H2O = acetate + H(+) + salicylate", "d": [], "t": []}, {"i": "EC:3.1.1.55", "l": "\"acetylsalicylate deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66290", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102649", "l": "acetoacetyl-ACP synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + malonyl-CoA + H+ + a holo-[acyl-carrier protein] = acetoacetyl-ACP + 2 coenzyme A + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090684", "l": "contact chemoreceptor activity", "d": ["A non-GPCR transmembrane signaling receptor activity that is responsible for contact chemoreception."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29022", "l": "D-galactose(in) + H(+)(in) <=> D-galactose(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047080", "l": "deoxyuridine 2'-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O2 = CO2 + succinate + uridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373087", "l": "Receptor CCR6 binds CCL20 ligand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21684", "l": "(R)-beta-alanopine + H2O + NAD(+) = beta-alanine + H(+) + NADH + pyruvate", "d": [], "t": []}, {"i": "EC:1.5.1.26", "l": "\"beta-alanopine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17250", "l": "2 Fe(2+) + 2 H2O + H2O2 => 6 H(+) + 2 iron(III) oxide-hydroxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18690", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O => a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76418", "l": "3',3'-cGAMP(out) + n H(+)(out) <=> 3',3'-cGAMP(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017159", "l": "pantetheine hydrolase activity", "d": ["Catalysis of the reaction: (R)-pantetheine + H2O = (R)-pantothenate + cysteamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25173", "l": "H2O + N(omega)-methyl-L-arginine = L-citrulline + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44918", "l": "(3E)-decenoyl-CoA + NADP(+) => (2E,4E)-decadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0072586", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity", "d": ["Binds to and modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50930", "l": "(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2454118", "l": "11cRAL binds to opsin to form 11c-retinyl:RHO (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362549", "l": "Hh-Np traffics to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44153", "l": "1D-myo-inositol 2-phosphate + H2O => myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24376", "l": "apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin = AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]", "d": [], "t": []}, {"i": "EC:6.3.4.11", "l": "\"biotin--[methylcrotonoyl-CoA-carboxylase] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9663511", "l": "BIL binds GSTA1, FABP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3371422", "l": "ATP hydrolysis by HSP70 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45353", "l": "9,10-epoxyoctadecanoate + H2O => 9,10-dihydroxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "55.260686396366907", "identifiers": [{"i": "GO:0016788", "l": "hydrolase activity, acting on ester bonds", "d": ["Catalysis of the hydrolysis of any ester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41635", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033702", "l": "(+)-trans-carveol dehydrogenase activity", "d": ["Catalysis of the reaction: (1R,5S)-carveol + NAD+ = (S)-carvone + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38100", "l": "a ribonucleoside 5'-triphosphate + phytyl phosphate => a ribonucleoside 5'-diphosphate + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59819", "l": "a long-chain fatty acyl-CoA + a sterol <=> a sterol ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37899", "l": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.42", "l": "\"tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23573", "l": "3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 3 CO2 + 4 CoA + phlorisovalerophenone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46548", "l": "a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-(4E,8E,10E)-sphingatrienine", "d": [], "t": []}, {"i": "EC:1.14.19.19", "l": "\"sphingolipid 10-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33368", "l": "D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] => D-glucose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198314", "l": "DAG stimulates protein kinase C-delta (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.15.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44675", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O <=> a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16668", "l": "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O <=> (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647660", "l": "GSDME (1-270) binds PIPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0000829", "l": "inositol heptakisphosphate kinase activity", "d": ["Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49572", "l": "Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)", "d": [], "t": []}, {"i": "EC:4.99.1.9", "l": "\"coproporphyrin ferrochelatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432952", "l": "BP180 interacts intracellularly with plectin and integrin beta4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938853", "l": "CDK6 binds RUNX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004138", "l": "deoxyguanosine kinase activity", "d": ["Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022819", "l": "potassium ion uniporter activity", "d": ["Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69313", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate => benzyl thiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31409", "l": "all-trans-4,4'-diapolycopene + FADH2 => all-trans-4,4'-diaponeurosporene + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1168633", "l": "NF-kappaB translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028583", "l": "Phosphorylation of YAP by LATS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48552", "l": "1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = (9S,13S,15Z)-12-oxophyto-10-15-dienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610758", "l": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10822", "l": "D-erythro-isocitrate => D-threo-isocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853956", "l": "Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140806", "l": "SERPINC1 binds SERPINC1 activators (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635850", "l": "GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65522", "l": "all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin] => all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72592", "l": "D-glucuronate(out) + H(+)(out) => D-glucuronate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707856", "l": "PGRMC2:Hemes dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218841", "l": "NADPH oxidase 2 generates superoxide from oxygen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44567", "l": "4-hydroxybenzoate + all-trans-decaprenyl diphosphate <=> 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57169", "l": "(R)-2-hydroxyglutarate + FAD + H(+) => 2-oxoglutarate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65644", "l": "(4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821368", "l": "AKAP8L binds MLL1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51927", "l": "AH2 + menaquinone-9 <=> A + beta-dihydromenaquinone-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64306", "l": "1-phenylpropan-1-one + L-alanine => 1-phenylpropylamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52904", "l": "15,17(3)-seco-F430-17(3)-acid + ATP = ADP + coenzyme F430 + phosphate", "d": [], "t": []}, {"i": "EC:6.4.1.9", "l": "\"coenzyme F430 synthetase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51682", "l": "(2E,6E)-farnesyl phosphate + CDP + H(+) => (2E,6E)-farnesol + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51518", "l": "(R)-tembetarine + H(+) + S-adenosyl-L-homocysteine => (R)-reticuline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928607", "l": "p-EPHs bind VAV2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3318415", "l": "ATF2 acetylates histone H2B, H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64031", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine <=> H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015200", "l": "methylammonium transmembrane transporter activity", "d": ["Enables directed movement of methylammonium, CH3NH2, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784765", "l": "p-Y705-STAT3 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28374", "l": "ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376886", "l": "Efflux of glucose and orthophosphate from the endoplasmic reticulum (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035473", "l": "lipase binding", "d": ["Binding to a lipase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3965447", "l": "G-protein subunits dissociate from WNT:FZD complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40501", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983707", "l": "SYK autophosphorylates at the activated BCR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9684068", "l": "ATP1A:ATP1B:FXYD binds cardiac glycosides (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769812", "l": "Spike Trimer Translocates to the Plasma Membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46795", "l": "an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404144", "l": "Parenchymal atROL translocates to HSCs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44507", "l": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate <=> a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65822", "l": "dec-9-enoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => decanoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78391", "l": "D-mannose(out) = D-mannose(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052623", "l": "ADP dimethylallyltransferase activity", "d": ["Catalysis of the reaction: delta2-isopentenyl diphosphate + ADP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-diphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64262", "l": "CoA + H(+) + N-(9Z,12Z-octadecadienoyl)-glycine => (9Z,12Z)-octadecadienoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045134", "l": "UDP phosphatase activity", "d": ["Catalysis of the reaction: UDP + H2O = UMP + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48066", "l": "a ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate => a ganglioside GD1b (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044022", "l": "histone H3S28 kinase activity", "d": ["Catalysis of the reaction: histone H3-serine (position 28) + ATP = histone H3-phosphoserine (position 28) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 28 of histone H3."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42272", "l": "3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] = 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52740", "l": "glyphosate + H2O + O2 = aminomethylphosphonate + glyoxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015310", "l": "benomyl:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30705", "l": "CO2 + phenol => H(+) + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197963", "l": "DHFR2 reduces FOLA to DHF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964605", "l": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61923", "l": "(2R,4S)-ketoconazole(in) + ATP + H2O <=> (2R,4S)-ketoconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18395", "l": "2-methyl-3-oxopropanoate + L-alanine => (R)-3-amino-2-methylpropanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168313", "l": "Virion-associated M2 protein mediated ion infusion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109759", "l": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.93", "l": "\"tartrate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39963", "l": "2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73959", "l": "2-methoxy-4-vinylphenol + H(+) + NADH = 4-ethyl-2-methoxyphenol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51339", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> 8-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78759", "l": "AH2 + L-isoleucyl-[protein] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + methylcyclopropylglycine-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26183", "l": "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O <=> 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54607", "l": "2-oxoglutarate + decanoyl-CoA + O2 <=> 2-hydroxydecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428696", "l": "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14869", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = acetate + an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46419", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426130", "l": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388468", "l": "AVP(20-28) binds AVPR1A,B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22318", "l": "13-(beta-D-glucosyloxy)docosanoate + H(+) + UDP => 13-hydroxydocosanoate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9006870", "l": "IL21 receptor STAT phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52620", "l": "3-methylbutanoyl-CoA = 2,2-dimethylpropanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759334", "l": "NFE2L2 binds the SRXN1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757954", "l": "N4BP1 binds IKBKG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086410", "l": "CDK1 phosphorylates BORA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0046920", "l": "alpha-(1->3)-fucosyltransferase activity", "d": ["Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21723", "l": "formamide <=> H2O + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202437", "l": "Phosphorylation of CARMA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68611", "l": "H(+) + isatin + NADPH <=> 3-hydroxyindolin-2-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.116", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029517", "l": "Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51929", "l": "H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) => (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38425", "l": "(9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+) => 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72814", "l": "L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) <=> L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205286", "l": "GRB2:SOS interacts with p-KIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686304", "l": "ZDHHC2 transfers PALM from PALM-CoA to CKAP4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373717", "l": "DCC interacts with DIP13alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14572", "l": "propane-1,2-diol <=> H2O + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23721", "l": "ATP + hydrogencarbonate + propanoyl-CoA => (S)-methylmalonyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11848", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine = [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:1.21.4.4", "l": "\"betaine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57338", "l": "3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP => 3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218815", "l": "p-6Y-VEGFR2 binds NCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42166", "l": "(5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + A + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755526", "l": "PIAS4 SUMOylates NR4A2 with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986985", "l": "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40733", "l": "(20S)-protopanaxadiol + 2 D-glucose => (20S)-ginsenoside Rg3 + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51100", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938913", "l": "RUNX1 binds ELF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683735", "l": "mRNA9 is translated to Nucleoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13901", "l": "H2O + N-(aminomethyl)urea = N-(hydroxymethyl)urea + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32807", "l": "thiosulfate(in) = thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5683593", "l": "ATG7:ATG3:LC3 dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215426", "l": "COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19635", "l": "(5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+) => (3S,5S)-3,5-diaminohexanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21828", "l": "H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.7.7.2", "l": "\"ferredoxin--nitrate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18094", "l": "5,6-dihydrouracil + NADP(+) => H(+) + NADPH + uracil", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0000213", "l": "tRNA-intron endonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11235", "l": "3'-phosphoadenylyl sulfate + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5681980", "l": "ATG12 binds ATG7 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48496", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose = 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6793591", "l": "LIAS synthesizes lipoyl-GCSH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050136", "l": "NADH:ubiquinone reductase (non-electrogenic) activity", "d": ["Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49449", "l": "beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O => alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75253", "l": "3'-dehydrocarminate + H2O2 => carminate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.159", "l": "\"theobromine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.4", "l": "\"NADH oxidase (H2O-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54056", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-hedycaryol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.174", "l": "\"(2E,6E)-hedycaryol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617064", "l": "SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50525", "l": "acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59198", "l": "AMP + H(+) + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] => holo-[(phenol)carboxyphthiodiolenone synthase] + icosanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852580", "l": "Clusterin binds C5b-C7, C8, C9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47432", "l": "(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54959", "l": "ATP + CoA + OPC-6 <=> AMP + diphosphate + OPC-6-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70846", "l": "L-arginine(in) + L-methionine(out) + Na(+)(out) <=> L-arginine(out) + L-methionine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.21", "l": "\"2-dehydro-3-deoxy-6-phosphogalactonate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64075", "l": "acetyl-CoA + 8 H(+) + holo-[ACP] + 8 malonyl-CoA <=> 3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 8 CO2 + 9 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008073", "l": "ornithine decarboxylase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ornithine decarboxylase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418925", "l": "ADORA2A,B bind Ade-Rib (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9754130", "l": "CDK4 inhibitors bind CDK4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000074", "l": "TCN2 binds RCbl in the circulation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179276", "l": "SMURF2 monoubiquitinates SMAD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42113", "l": "(20S)-hydroxypregn-4-en-3-one + NADP(+) => H(+) + NADPH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18792", "l": "D-glucosamine 6-phosphate <=> D-galactosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9823816", "l": "OPTN binds CASP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11381", "l": "2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 => [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71844", "l": "tauroursodeoxycholate(out) => tauroursodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20399", "l": "H(+) + L,L-cystathionine + succinate => L-cysteine + O-succinyl-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21431", "l": "(2R)-3-sulfolactate <=> H(+) + pyruvate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168326", "l": "Assembly of an Active Transcription Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102684", "l": "L-phenylalanine N-monooxygenase activity", "d": ["Catalysis of the reaction: L-phenylalanine + 2 NADPH + 2 O2 + 2 H+ = (E)-phenylacetaldehyde oxime + 2 NADP + 3 H2O + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44031", "l": "L-altrarate <=> 5-dehydro-4-deoxy-D-glucarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000156", "l": "phosphorelay response regulator activity", "d": ["Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209536", "l": "IkB is ubiquitinated and degraded (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640862", "l": "Tankyrase binds AXIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17548", "l": "[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] <=> [protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42258", "l": "3-oxooctanoyl-[ACP] + CO2 + CoA => H(+) + hexanoyl-CoA + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11242", "l": "ADP + thiamine triphosphate => ATP + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015212", "l": "cytidine transmembrane transporter activity", "d": ["Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-425983", "l": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53845", "l": "glycochenodeoxycholate + NAD(+) => 7-oxoglycolithocholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009227", "l": "IL20 binds to IL22RA1:JAK1:IL20RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65924", "l": "2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine = 2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54086", "l": "archaeosine(15) in tRNA + L-glutamate => 7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20075", "l": "acetaldehyde + glycine => D-allo-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168136", "l": "Activated JNKs phosphorylate c-JUN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70854", "l": "H(+)(out) + K(+)(in) + L-aspartate(out) + 3 Na(+)(out) <=> H(+)(in) + K(+)(out) + L-aspartate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0120017", "l": "ceramide transfer activity", "d": ["Removes a ceramide from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156823", "l": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14635", "l": "ADP + H(+) + Na(+)(out) + phosphate => ATP + H2O + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805638", "l": "KAT6A acetylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35002", "l": "ADP(in) + ATP(out) <=> ADP(out) + ATP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65048", "l": "4-acetoxybenzyl alcohol + NAD(+) = 4-acetoxybenzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.68", "l": "\"isoamylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008084", "l": "imaginal disc growth factor receptor binding", "d": ["Binding to an imaginal disc growth factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44100", "l": "H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689317", "l": "Formation of the pre-incision complex in GG-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005540", "l": "hyaluronic acid binding", "d": ["Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0015020", "l": "glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102366", "l": "7-beta-hydroxytaxusin 2-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: 7-beta-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7-beta-dihydroxytaxusin + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202164", "l": "Translocation of PDK1 to Plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63674", "l": "H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NAD(+) => (8S)-8-amino-7-oxononanoate + H(+) + L-lysyl-[protein] + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046905", "l": "15-cis-phytoene synthase activity", "d": ["Catalysis of the reaction: 2 geranylgeranyl diphosphate -> 15-cis-phytoene + 2 diphosphate."], "t": []}, {"i": "RHEA:34479", "l": "(1R,2R,3R)-prephytoene diphosphate = 15-cis-phytoene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42756", "l": "cytidine(1407) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1407) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.178", "l": "\"16S rRNA (cytosine(1407)-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48967", "l": "2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 <=> [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0016918", "l": "retinal binding", "d": ["Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62681", "l": "naphtopyrone YWA1 => H(+) + H2O + norrubrofusarin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0050431", "l": "transforming growth factor beta binding", "d": ["Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73945", "l": "FAS-mediated dimerization of procaspase-8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24997", "l": "N-hydroxy-L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607726", "l": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26348", "l": "L-galactonate + NADP(+) <=> aldehydo-D-galacturonate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19102", "l": "2-butyne-1,4-diol + NAD(+) => 4-hydroxy-2-butynal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62975", "l": "acetyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 3 CO2 + 4 CoA + orsellinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51041", "l": "indole-3-pyruvate imine dimer => chromopyrrolate + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23262", "l": "15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH => (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58603", "l": "2 L-ascorbate + N-(9Z-octadecenoyl)glycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-(9Z-octadecenoyl)-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000122", "l": "CD320 binds extracellular TCN2:RCbl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77505", "l": "(2S)-2-hydroxy-4-phenylbutanenitrile => 3-phenylpropanal + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13371", "l": "diphosphate + isoprene => dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427656", "l": "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16127", "l": "ADP + D-fructose 6-phosphate + H(+) => ATP + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67416", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78564", "l": "(3R)-hydroxytetracosanoyl-CoA + NAD(+) => 3-oxotetracosanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n4", "l": "\"ankyrin-repeat-histidine dioxagenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803104", "l": "DCD forms oligomeric complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63832", "l": "(6E)-8-methylnon-6-enoyl-CoA + vanillylamine = capsaicin + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.2.35", "l": "\"capsaicin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449058", "l": "Interleukin-1 family are secreted (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166387", "l": "The FA anion diffuses away laterally from UCP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046175", "l": "Further sulfation on galactose residues produces KSPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14917", "l": "3 O2 + obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44610", "l": "2-methoxy-6-(all-trans-nonaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-nonaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31714", "l": "beta-amyrin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 11-oxo-beta-amyrin + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21052", "l": "(S)-2-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.269", "l": "\"2-(S)-hydroxypropyl-CoM dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45400", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114352", "l": "Sequestration of tBID by BCL-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66981", "l": "2-methylbutanoyl-CoA + H2O => 2-methylbutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001888", "l": "glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66657", "l": "Cu(2+)(out) + L-ascorbate(in) => Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52456", "l": "testosterone + UDP-alpha-D-glucuronate = H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46428", "l": "4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37966", "l": "galactitol + NAD(+) <=> D-galactose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192417", "l": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25340", "l": "isocyanate + NH4(+) => H(+) + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78239", "l": "D-allo-threonine + H2O + O2 = (R)-3-hydroxy-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66666", "l": "ADP + coproporphyrin III(out) + H(+) + phosphate => ATP + coproporphyrin III(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430190", "l": "p-SLP-76 binds NCK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762333", "l": "ANGPTL4 binds to CDH11v (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74630", "l": "NADPH + 2 O2 + prefumagillin <=> acetaldehyde + fumagillin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61347", "l": "H2O + L-serine + O2 <=> 3-hydroxypyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950342", "l": "EBI3:CANX binds IL27 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16124", "l": "5,6-dihydrouracil + H2O <=> 3-(carbamoylamino)propanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64697", "l": "benzyl alcohol + NAD(+) => benzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549493", "l": "Expression of PERIOD-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10465", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O => n acetate + chitosan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11172", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine", "d": [], "t": []}, {"i": "EC:2.1.1.13", "l": "\"methionine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75146", "l": "TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757706", "l": "HSD11B1 hydrogenates PREDN to PREDL in hepatic cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.3.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014433", "l": "RHOG GEFs activate RHOG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051073", "l": "adenosylcobinamide-GDP ribazoletransferase activity", "d": ["Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17044", "l": "adenosine 5'-phosphosulfate + H2O <=> AMP + 2 H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218827", "l": "NADPH oxidase 2 (NOX2) complex binds RAC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.19", "l": "\"cyclomaltodextrin glucanotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12808", "l": "(S)-canadine + S-adenosyl-L-methionine <=> (S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849085", "l": "ARHGAP35 binds RHOA:GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44198", "l": "3-methylundecanoyl-CoA + AMP + diphosphate => 3-methylundecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72843", "l": "3'-dephospho-CoA(in) + ADP(out) = 3'-dephospho-CoA(out) + ADP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264458", "l": "Proteasome mediated degradation of COP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804879", "l": "MDM2 ubiquitinates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68042", "l": "(3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+) => (R)-lanthionine ketimine + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008672", "l": "2-dehydro-3-deoxyglucarate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24019", "l": "16-epivellosimine + acetyl-CoA <=> CoA + vinorine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36886", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.2", "l": "\"alcohol dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52579", "l": "hexanoyl-CoA + NAD(+) <=> (2E)-hexenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036200", "l": "3-ketosteroid 9-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: androsta-1,4-diene-3,17-dione + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448744", "l": "IL20RA binds IL20RB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030771", "l": "N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity", "d": ["Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40158", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050380", "l": "undecaprenyl-diphosphatase activity", "d": ["Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58082", "l": "docosanoate + glycerol + H(+) => 1-docosanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653957", "l": "Rag dimer formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62241", "l": "a thymidine(6-4)cytidine in DNA => a thymine-cytidine dinucleotide in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106078", "l": "histone succinyltransferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013108", "l": "GDIs block activation of RHOC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809680", "l": "MTMR12 binds MTM1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.55", "l": "\"caldesmon-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912406", "l": "p53 positively regulates transcription of MIR34 microRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216727", "l": "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27901", "l": "3'-AMP + H2O <=> adenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69894", "l": "Na(+)(out) + thymidine(out) <=> Na(+)(in) + thymidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031517", "l": "red light photoreceptor activity", "d": ["The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64603", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46358", "l": "18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + octadecanoate + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28184", "l": "(1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate => (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449855", "l": "IL10 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.249984622034518", "identifiers": [{"i": "GO:0140101", "l": "catalytic activity, acting on a tRNA", "d": ["Catalytic activity that acts to modify a tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852019", "l": "MET bound PI3K generates PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51249", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61705", "l": "ATP + holo-[peptidyl-carrier protein] + L-serine => AMP + diphosphate + L-seryl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9612501", "l": "SGK phosphorylates CREB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19035", "l": "an N-acyl-D-mannosamine => an N-acyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034885", "l": "gamma-N-formylaminovinylacetate hydrolase activity", "d": ["Catalysis of the reaction: gamma-N-formylaminovinylacetate + H2O = gamma-aminovinylacetate + HCOOH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0015214", "l": "pyrimidine nucleoside transmembrane transporter activity", "d": ["Enables the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33697", "l": "3-oxoeicosasphinganine + H(+) + NADPH => C20 sphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47446", "l": "(5Z)-tetradecenoyl-CoA + acetyl-CoA => 3-oxo-(7Z-hexadecenoyl)-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015052", "l": "beta3-adrenergic receptor activity", "d": ["Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675431", "l": "PP2A dephosphorylates RAF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.77", "l": "\"oleate 10S-lipoxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694462", "l": "ABHD6,12 hydrolyse 3AG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18260", "l": "coproporphyrinogen III + 2 H(+) + O2 <=> 2 CO2 + 2 H2O + protoporphyrinogen IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35653", "l": "an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+) => (4R)-hydroxysphinganine + a fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21080", "l": "ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine", "d": [], "t": []}, {"i": "EC:2.5.1.6", "l": "\"methionine adenosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362386", "l": "Glycosylation of Hh (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781814", "l": "USP19 deubiquitinates RNF123 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54347", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline <=> 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58564", "l": "15alpha-stemmadenine + NADP(+) = 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61861", "l": "dehydroprobetaenone I + H(+) + NADPH + O2 => epoxybetaenone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9846305", "l": "ST6GALNAC5,6 transfer Neu5Ac to GM1b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19031", "l": "2 CO2 + 2 NH4(+) => 3 H(+) + H2O + urea-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676152", "l": "PI4KB binds to ARF1/3:GTP at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63278", "l": "a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52290", "l": "7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848247", "l": "ACBD4,5 bind MCFA-CoA and LCFA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854329", "l": "TBC1D15 accelerates GTP hydrolysis by RAB7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-203700", "l": "eNOS translocation from Golgi to Caveolae (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68849", "l": "(2Z,6E)-farnesyl diphosphate => diphosphate + gamma-cadinene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54191", "l": "H2O + N-acetyl-L-phenylalanine <=> acetate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10113", "l": "L-homocysteine + L-serine => H2O + L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46509", "l": "NADH + nitrobenzene + O2 => catechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811425", "l": "NSF and SNAPs bind cis-SNARE at the ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162193", "l": "COQ3 methylates DHDB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21559", "l": "[calmodulin]-L-lysine + S-adenosyl-L-methionine <=> [calmodulin]-N(6)-methyl-L-lysine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015333", "l": "peptide:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63741", "l": "2-phenylacetaldehyde + H(+) + NADH => 2-phenylethanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39296", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + AH2 + O2 => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52307", "l": "H2O + L-ectoine <=> (2S)-2-acetamido-4-aminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798748", "l": "Exocytosis of secretory granule lumen proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44970", "l": "NADP(+) + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76386", "l": "CYP1A2 S-demethylates 6MMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51939", "l": "2-(glutathione-S-yl)-hydroquinone + glutathione <=> glutathione disulfide + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55452", "l": "beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase] = daturadiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.64", "l": "\"beta-amyrin 6beta-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59236", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = diphosphate + isoelisabethatriene", "d": [], "t": []}, {"i": "EC:4.2.3.203", "l": "\"isoelisabethatriene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696547", "l": "STAMBPL1 is a deubiquitinase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601887", "l": "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43533", "l": "a ribonucleoside 3',5'-bisphosphate + H2O => a ribonucleoside 5'-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61865", "l": "AH2 + dehydroprobetaenone I => A + probetaenone I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21148", "l": "indole-3-acetyl-1D-myo-inositol + UDP-alpha-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.156", "l": "\"indolylacetyl-myo-inositol galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72559", "l": "estrone 3-sulfate(out) + pentanoate(in) = estrone 3-sulfate(in) + pentanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33422", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748991", "l": "XDH oxidises 6MP to 6TU (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004583", "l": "dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44356", "l": "nogalaviketone = methyl nogalonate", "d": [], "t": []}, {"i": "EC:5.5.1.26", "l": "\"nogalonic acid methyl ester cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47747", "l": "demethylphylloquinone + H(+) + NADPH <=> demethylphylloquinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50716", "l": "dimethyl sulfone + FMNH2 + O2 = FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72767", "l": "acetyl-CoA + 9 H(+) + 4 malonyl-CoA + 5 NADPH = 7-methylmellein + 3 CO2 + 5 CoA + 4 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30122", "l": "dodecanoyl-[ACP] + H2O <=> dodecanoate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034924", "l": "cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-3,4-phenanthrenedihydrodiol-4-carboxylate = 3,4-dihydroxyphenanthrene + H+ + 2 e- + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381461", "l": "Plasmin proteolyzes IGF:IGFBP-3:ALS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21682", "l": "2-oxophytanate + H2O2 => (2S)-2-hydroxyphytanate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685655", "l": "CTSL bind CTSL inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77049", "l": "4-phenylbutan-2-one + H(+) + NADH + NH4(+) => 4-phenylbutan-2-amine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16257", "l": "alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.231", "l": "\"alpha,alpha-trehalose phosphorylase (configuration-retaining)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18119", "l": "H2O + L-dopaquinone => L-tyrosine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201443", "l": "Type II receptor phosphorylates type I receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36676", "l": "octacosanoyl-CoA + sphinganine => CoA + H(+) + N-(octacosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864453", "l": "TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers bind the ERBB2 gene promoter and recruit YY1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45290", "l": "2-glyceryl-prostaglandin G2 => 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44006", "l": "a 3-methyl fatty acyl-CoA + AMP + diphosphate => 3-methyl fatty acid + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8963915", "l": "1,25(OH)2D binds VDR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20166", "l": "H2O + N(5)-acyl-L-ornithine ester => an alcohol + H(+) + N(5)-acyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847534", "l": "RAB43 hydrolyses GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615536", "l": "MECP2 and SOX2 bind MIR137 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54497", "l": "ent-copalyl diphosphate => diphosphate + ent-atiserene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18460", "l": "D-ribulose 5-phosphate <=> (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28251", "l": "acetyl-CoA + H(+) + malonyl-CoA => acetoacetyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5674022", "l": "BRAP autoubiquitinates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66110", "l": "(2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate => 2-oxobutanoate + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41259", "l": "L-tryptophan = (E)-3-(indol-3-yl)acrylate + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.31", "l": "\"L-tryptophan ammonia lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090686", "l": "glycine betaine-activated nonselective monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a monoatomic cation by a channel that opens when glycine betaine has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59499", "l": "(20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-ginsenoside C-K + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1470009", "l": "Phosphorylation of STATs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73088", "l": "AMP(out) + FAD(in) => AMP(in) + FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2471621", "l": "Endostatin degradation by cathepsins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19402", "l": "methanol + NAD(+) => formaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.571199156962493", "identifiers": [{"i": "GO:0070851", "l": "growth factor receptor binding", "d": ["Binding to a growth factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848436", "l": "PTK6 phosphorylates CDKN1B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9641109", "l": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27545", "l": "methanol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419003", "l": "Interaction of Nectins with Afadin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9674095", "l": "PDGFRs bind type II TKI (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103117", "l": "UDP-3-O-acyl-N-acetylglucosamine deacetylase activity", "d": ["Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O = UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8943279", "l": "GGT dimers hydrolyse GSH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389862", "l": "Conversion of glyoxylate to oxalate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839363", "l": "TGFBR3 phosphorylation by TGFBR2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54290", "l": "diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein] => ATP + L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66430", "l": "D-arabinose(in) + H(+)(in) => D-arabinose(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71356", "l": "5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) => 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13869", "l": "NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH", "d": [], "t": []}, {"i": "EC:1.3.1.12", "l": "\"prephenate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23152", "l": "a ubiquinone + H(+) + NADH = a ubiquinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59630", "l": "4-aminobutanoate + L-arginine => H2O + N(2)-(4-aminobutanoyl)-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810937", "l": "Lamellar bodies bind the early cornified envelope (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51079", "l": "2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate <=> 2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1454916", "l": "The ABCC family mediates organic anion transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265959", "l": "Phosphorylation of Chk2 by ATM upon DNA damage (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40244", "l": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) => 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49956", "l": "5,10-dihydrophenazine 1-carboxylate + O2 = H2O2 + phenazine-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75712", "l": "a rhodoquinone + succinate => a rhodoquinol + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110215", "l": "Cleavage of uracil by UNG glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868118", "l": "MAPK12 phosphorylates PTPN3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047183", "l": "anthocyanin 5-aromatic acyltransferase activity", "d": ["Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12152", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene = (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68349", "l": "ATP + GTP => diphosphate + pppA(2'-5')pG", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161293", "l": "Tropoelastin forms aggregate globules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73336", "l": "ATP + beta-alanine + tryptamine => AMP + beta-alanyl-tryptamine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50837", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 => 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2467775", "l": "Autocleavage of ESPL1 (Separase) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654169", "l": "p-4Y-PLCG1 dissociates from activated FGFR4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18523", "l": "2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine => licodione + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018807", "l": "RAC3 GDIs block activation of RAC3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047917", "l": "GDP-glucosidase activity", "d": ["Catalysis of the reaction: GDP-D-glucose + H2O = D-glucose + GDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856808", "l": "Recruitment of AP-2 complex and clathrin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.942687253280909", "identifiers": [{"i": "GO:0004619", "l": "phosphoglycerate mutase activity", "d": ["Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-350651", "l": "Caspase-mediated cleavage of MASK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106073", "l": "dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity", "d": ["Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48707", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49653", "l": "H(+) + NADH + O2 + protoviolaceinate => H2O + NAD(+) + violaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51857", "l": "(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) => (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68442", "l": "(3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal => beta-cryptoxanthin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63843", "l": "[thioredoxin]-dithiol + tert-butyl hydroperoxide <=> [thioredoxin]-disulfide + H2O + tert-butanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10784", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + L-lysyl(36)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45141", "l": "2,3-epoxyphylloquinone + 4-carboxy-L-glutamyl-[protein] + H(+) + H2O => CO2 + L-glutamyl-[protein] + O2 + phylloquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12969", "l": "a sn-glycero-3-phosphodiester + H2O = an alcohol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54846", "l": "ethyl butanoate + H2O + NADP(+) => H(+) + hexan-3-one + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047270", "l": "lipopolysaccharide glucosyltransferase II activity", "d": ["Catalysis of the reaction: lipopolysaccharide + UDP-D-glucose = D-glucosyl-lipopolysaccharide + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29832", "l": "Ni(2+)(in) => Ni(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964274", "l": "G alpha (12) binds BTK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47669", "l": "H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) => 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2065355", "l": "Secreted ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49622", "l": "D-erythrulose 1-phosphate + H(+) + NADPH => D-erythritol 1-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9824977", "l": "MAPK1-dependent phosphorylation of MITF-M (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34998", "l": "L-rhamnose(in) <=> L-rhamnose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68815", "l": "(2Z,6E)-farnesyl diphosphate <=> beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63382", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26547", "l": "beta-alaninamide + H2O => beta-alanine + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446089", "l": "BP180 interacts extracellularly with Laminin 332 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79030", "l": "alpha-D-Man-(1->6)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76747", "l": "hexadecane + O2 + reduced [NADPH--hemoprotein reductase] = 9-hexadecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36859", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66503", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660662", "l": "ASC binds Caspase-8 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047730", "l": "carnosine synthase activity", "d": ["Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65366", "l": "a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP => a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28739", "l": "Cd(2+)(in) + H(+)(out) = Cd(2+)(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39207", "l": "3-oxohexacosanoyl-CoA + H(+) + NADPH = (3R)-hydroxyhexacosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56704", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 = 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.12", "l": "\"3-[(E)-2-isocyanoethenyl]-1H-indole synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16824", "l": "6-phospho-D-gluconate + NAD(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42927", "l": "cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26265", "l": "dehydroabietadienal + H2O + NADP(+) = dehydroabietate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2129375", "l": "Elastin cross-linking by lysyl oxidase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085027", "l": "Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035715", "l": "chemokine (C-C motif) ligand 2 binding", "d": ["Binding to chemokine (C-C motif) ligand 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4395231", "l": "E2F1/3:DP1/2 binds NOTCH1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37681", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49467", "l": "2,6-dihydroxybenzoate + H(+) <=> CO2 + resorcinol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161795", "l": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9627078", "l": "XIAP binds CASP9 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12907", "l": "GDP-alpha-D-mannose + phosphate => alpha-D-mannose 1-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660665", "l": "Caspase-8 binds MALT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810376", "l": "ING2 binds PI5P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709109", "l": "DHFR dimer binds DHFR inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22746", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41093", "l": "1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47462", "l": "(3Z)-dodecenoyl-CoA + acetyl-CoA => 3-oxo-(5Z-tetradecenoyl)-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9633005", "l": "EIF2AK4 (GCN2) binds tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18201", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa", "d": [], "t": []}, {"i": "EC:1.14.16.2", "l": "\"tyrosine 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033130", "l": "acetylcholine receptor binding", "d": ["Binding to an acetylcholine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65012", "l": "decanoyl-AMP + holo-[ACP] = AMP + decanoyl-[ACP] + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411367", "l": "TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11225", "l": "ATP + 2 D-alanine => ADP + D-alanyl-D-alanine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199202", "l": "Phosphopantetheine conjugation of the ACP domain of FAS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55287", "l": "all-trans-retinol + tetradecanoyl-CoA <=> all-trans-retinyl tetradecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839381", "l": "FGF2:TGFBR3 binding to GIPC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70512", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->3)-alpha-L-fucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.129", "l": "\"acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77653", "l": "2-[(1R,8S,14R,15R)-11-hydroxy-14,15-bis[(6E)-oct-6-en-1-yl]-3,5,9-trioxo-4,10-dioxatetracyclo[9.4.0.0(2,6).0(8,12)]pentadeca-2(6),12-dien-8-yl]acetate + CO2 => 2 [4-(deca-1,8-diyl)-2,5-dioxo-2,5-dihydro-3-furanyl]acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389841", "l": "MTFMT formylates methionyl-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28806", "l": "H2O + L-ascorbate 6-phosphate <=> 3-dehydro-L-gulonate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39823", "l": "eicosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 2-hydroxyeicosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69707", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O = beta-D-galactose + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209925", "l": "DIT and MIT combine to form triiodothyronine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.70", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47814", "l": "9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720432", "l": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63807", "l": "GDP-beta-L-gulose <=> GDP-beta-L-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395517", "l": "NADPH transfers electrons to FDXR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654151", "l": "Activated FGFR4 phosphorylates PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22189", "l": "an (R)-2-haloacid + H2O => a (2S)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36825", "l": "CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-phosphate => 1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416516", "l": "GRK2 sequesters activated Gq (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48644", "l": "prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42271", "l": "2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] <=> 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31738", "l": "3-oxocholan-24-oyl-CoA + NAD(+) <=> 3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5632738", "l": "DDIT4 binds 14-3-3 dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66443", "l": "butan-2-one + NADP(+) <=> but-3-en-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209370", "l": "CI75 transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74057", "l": "D-cysteine(in) + L-alanine(out) => D-cysteine(out) + L-alanine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40568", "l": "AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 => A + dTDP-beta-L-evernitrose + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77713", "l": "Fe(II)-heme b-[protein] + 2 H(+) + nitrite => Fe(III)-heme b-[protein] + H2O + nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102417", "l": "apigenin-7-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: apigenin 7-O-beta-D-glucoside + UDP-alpha-D-glucose = apigenin-7-O-gentiobioside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59557", "l": "H2O + N,N'-diacetylchitobiono-1,5-lactone => H(+) + N,N'-diacetylchitobionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210292", "l": "Interaction of DAP12 and TREM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12731", "l": "(3R,3'S)-zeaxanthin => lutein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49115", "l": "phenazine-1-carboxylate + S-adenosyl-L-methionine <=> 5-methyl-phenazine-1-carboxylate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38836", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34266", "l": "dimethylallyl diphosphate + fumigaclavine A <=> diphosphate + fumigaclavine C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73236", "l": "2,6-dichlorobenzoquinone + H2O => 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8857662", "l": "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10571", "l": "luteolin + UDP-alpha-D-glucuronate <=> H(+) + luteolin 7-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15216", "l": "N(6)-[(R)-dihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA <=> CoA + N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163010", "l": "Down Regulation of Emi1 through Phosphorylation of Emi1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391940", "l": "EP2 and EP4 receptors can bind PGE2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388809", "l": "CTLA-4 binds B7-1/B7-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63895", "l": "ATP + H2O + L-tryptophan <=> AMP + D-tryptophan + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444654", "l": "G-protein coupled bile acid receptor binds lithocholic acid (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53178", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102967", "l": "10-hydroxygeraniol oxidoreductase activity", "d": ["Catalysis of the reaction: (6E)-8-hydroxygeraniol + NADP = (6E)-8-hydroxygeranial + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981931", "l": "RAC1 and CDC42 activate PAK2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033843", "l": "xyloglucan 6-xylosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.21", "l": "\"coagulation factor VIIa\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615015", "l": "FOXO6 binds PLXNA4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59353", "l": "beta-lactose + O2 => H2O2 + lactobiono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46803", "l": "H(+) + Na(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> Na(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2666278", "l": "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53616", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-isoafricanol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.157", "l": "\"(+)-isoafricanol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071795", "l": "K11-linked polyubiquitin modification-dependent protein binding", "d": ["Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 11 in the target protein."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41013", "l": "(+)-sesamin monocatechol + (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) => (+)-sesamin + (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73580", "l": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56364", "l": "13-dihydrocarminomycin + H(+) + NADPH + O2 = carminomycin + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008107", "l": "galactoside 2-alpha-L-fucosyltransferase activity", "d": ["Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047369", "l": "succinate-hydroxymethylglutarate CoA-transferase activity", "d": ["Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805730", "l": "SETD9 methylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75862", "l": "Fall Back to Closed Pre-initiation Complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818682", "l": "MEN1 binds MLL2 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635839", "l": "ULK3:SUFU dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446372", "l": "Association of  PARVA with TESK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17811", "l": "Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine => Mg-protoporphyrin IX + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947531", "l": "Molybdenum ion transfer onto molybdopterin (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48900", "l": "chlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] = 3,8-divinyl chlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47809", "l": "epothilone D + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => epothilone B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72710", "l": "GDP-beta-L-fucose(in) + GMP(out) <=> GDP-beta-L-fucose(out) + GMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20167", "l": "an alcohol + H(+) + N(5)-acyl-L-ornithine => H2O + N(5)-acyl-L-ornithine ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800793", "l": "PIDD1 translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14295", "l": "D-glucono-1,5-lactone + H(+) + NADH => D-glucose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990409", "l": "adrenomedullin binding", "d": ["Binding to adrenomedullin (AM)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391168", "l": "SIRP gamma binds CD47 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13763", "l": "S-adenosyl-L-homocysteine + S-methyl-L-methionine => L-methionine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49992", "l": "H(+) + NADH + O2 + propane = H2O + NAD(+) + propan-2-ol", "d": [], "t": []}, {"i": "EC:1.14.13.227", "l": "\"propane 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034004", "l": "germacradienol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59275", "l": "L-cysteine <=> D-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22833", "l": "H2O + N-formimidoyl-L-glutamate => N-formyl-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047718", "l": "indanol dehydrogenase activity", "d": ["Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33788", "l": "3'-ketolactose + H2O => 3-keto-beta-D-galactose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29910", "l": "H2O + sn-glycero-3-phospho-(1'-rac-glycerol) <=> glycerol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39689", "l": "(2E,11Z)-octadecadienoyl-CoA + H2O => (R)-3-hydroxy-(11Z)-octadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32100", "l": "S-adenosyl-L-methionine + TRIBOA beta-D-glucoside => DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36434", "l": "a purine 2'-deoxy-D-ribonucleoside + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45965", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O => 2 AMP + ATP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39337", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+) => 3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9829200", "l": "F0 is cleaved, releasing F1, F2, F(110-136) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31811", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + viridiflorene", "d": [], "t": []}, {"i": "EC:4.2.3.88", "l": "\"viridiflorene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32645", "l": "17-hydroxylupanine + 2 Fe(II)-[cytochrome c] + 2 H(+) => 2 Fe(III)-[cytochrome c] + H2O + lupanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66490", "l": "quillaic acid 28-beta-D-glucoside + UDP => quillate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985914", "l": "IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73921", "l": "H2O + norlichexanthone => 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49417", "l": "ADP + alpha-D-ribose 1-phosphate => alpha-D-ribose 1,5-bisphosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17718", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP => 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48637", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54059", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (2E,6E)-hedycaryol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76766", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,4-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74071", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046715", "l": "active borate transmembrane transporter activity", "d": ["Enables the transport of borate across a membrane against the concentration gradient."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473596", "l": "Collagen type I degradation by MMP15 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0044013", "l": "histone H2B acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48177", "l": "decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25781", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine => 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72051", "l": "butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24625", "l": "ATP + L-threonine + tRNA(Thr) => AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8867240", "l": "EPCAM binds itself to form homotypic cell adhesion (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43178", "l": "5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62415", "l": "(E)-feruloyl-CoA + H2O <=> acetyl-CoA + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.15", "l": "\"D-iditol 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3159259", "l": "MMAA:MUT binds AdoCbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928646", "l": "EPHAs bind EFNAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033841", "l": "6G-fructosyltransferase activity", "d": ["Catalysis of the reaction: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22127", "l": "17-O-acetylajmaline + H2O <=> acetate + ajmaline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77278", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA <=> 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0051219", "l": "phosphoprotein binding", "d": ["Binding to a phosphorylated protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73290", "l": "(2S)-naringenin + S-adenosyl-L-methionine <=> (2S)-naringenin 4'-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38383", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37234", "l": "H2O + L-alaninamide <=> L-alanine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11725", "l": "[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite => 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60373", "l": "D-fructose(out) => D-fructose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16307", "l": "3-hydroxy-3-methylglutarate + CoA + H(+) => (3S)-hydroxy-3-methylglutaryl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-198599", "l": "AKT phosphorylates MDM2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51415", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> (8R)-hydroperoxy-(5Z,9E,11Z,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25351", "l": "H2O + L-cysteinyl-tRNA(Pro) = H(+) + L-cysteine + tRNA(Pro)", "d": [], "t": []}, {"i": "EC:3.6.1.n2", "l": "\"L-cysteinyl-tRNA(Pro)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806831", "l": "CYB5Rs reduce MetHb to HbA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266328", "l": "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35988", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14469", "l": "2-aminomuconate 6-semialdehyde + H2O + NAD(+) = (2Z,4E)-2-aminomuconate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.32", "l": "\"aminomuconate-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3560789", "l": "Defective SLC26A2 does not cotransport extracellular SO4(2-), H+ to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74373", "l": "a carboxylate(in) + nicotinate(out) => a carboxylate(out) + nicotinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864577", "l": "TFAP2C translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5660980", "l": "p-S276-RELA binds RELB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20049", "l": "1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide", "d": [], "t": []}, {"i": "EC:3.5.4.19", "l": "\"phosphoribosyl-AMP cyclohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1562626", "l": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6785594", "l": "FANCD2 binds FANCI (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37376", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.59", "l": "\"tryptophan 6-halogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44423", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H2O <=> a 1-acyl-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52428", "l": "12-oxo-leukotriene B4 + H(+) + NADH = 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19431", "l": "[beta-adrenergic receptor]-phosphate + ADP + H(+) => [beta-adrenergic receptor] + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905060", "l": "calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration", "d": ["Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874204", "l": "MBTPS1 (S1P) cleaves CREB3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57559", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12194", "l": "(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9861626", "l": "SIRT4 cleaves lipoyl from DLAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159868", "l": "Furin cleaves pro-factor VII to factor VII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23078", "l": "2,4-dichlorobenzoyl-CoA + NADPH => 4-chlorobenzoyl-CoA + chloride + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10139", "l": "2 glyoxylate + H(+) <=> 2-hydroxy-3-oxopropanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102630", "l": "gossypetin 8-methyl ester 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5,7-pentahydroxy-8-methoxyflavon-3-olate + S-adenosyl-L-methionine = gossypetin 3',8-dimethyl ether + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15450", "l": "homogentisate + O2 => 4-maleylacetoacetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78541", "l": "4 H(+) + 4 nitrite => 2 H2O + 4 nitric oxide + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36248", "l": "(E)-anol + S-adenosyl-L-methionine => (E)-anethole + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950537", "l": "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18185", "l": "adenosine + O2 = 5'-dehydroadenosine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77396", "l": "hydrogen cyanide + propanal => (2S)-2-hydroxybutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60978", "l": "(E)-4-hydroxynon-2-enal + H(+) + NADH => (E)-4-hydroxynon-2-en-1-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35400", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine => beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008685", "l": "2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity", "d": ["Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46649", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA => androst-4-ene-3,17-dione + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614605", "l": "Persulfide sulfur is dioxygenated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23960", "l": "H(+) + 2 H2O2 + hexadecanoate = CO2 + 3 H2O + pentadecanal", "d": [], "t": []}, {"i": "EC:1.11.1.3", "l": "\"fatty-acid peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27411", "l": "3 a menaquinol + protoporphyrin IX => 3 a menaquinone + protoporphyrinogen IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159771", "l": "Furin cleaves pro-protein C to protein C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759860", "l": "FOXF1 binds the GATA4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39645", "l": "(18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + NADP(+) => (2E,18Z,21Z,24Z,27Z,30Z,33Z)-hexatriacontaheptaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009392", "l": "N-acetyl-anhydromuramoyl-L-alanine amidase activity", "d": ["Catalysis of the reaction: GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-DAP-D-Ala + H2O glcNAc-1,6-anhMurNAc + L-Ala-gamma-D-Glu-DAP-D-Ala."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62716", "l": "stemphyloxin I = stemphyloxin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66358", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H(+) + NADH => (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202307", "l": "Change of PKC theta conformation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19699", "l": "11-cis-retinol + H(+) + hexadecanoate => 11-cis-retinyl hexadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58659", "l": "a 5'-end 5'-phospho-ribonucleoside-RNA + S-adenosyl-L-methionine <=> a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46402", "l": "(25R)-cholest-5-ene-3beta,26-diol + H2O + 2 oxidized [adrenodoxin] => cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11427", "l": "ATP + L-threonyl-[myosin heavy-chain] <=> ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102621", "l": "emindole-SB NADPH:oxygen oxidoreductase (14,15-epoxidizing) activity", "d": ["Catalysis of the reaction: emindole-SB + O2 + NADPH + H+ = 14,15-epoxyemindole-SB + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53442", "l": "18-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5671737", "l": "p-T774-PKN1 binds CDC25C (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987214", "l": "p-STAT3 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948034", "l": "FGR binds LDL:LRP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76170", "l": "glycyl-L-leucine(out) + 2 H(+)(out) <=> glycyl-L-leucine + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4411402", "l": "Activation of NLK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76131", "l": "3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0046403", "l": "polynucleotide 3'-phosphatase activity", "d": ["Catalysis of the reaction: a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O = a 3'-end 2'-deoxyribonucleotide-DNA + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106422", "l": "carotenoid isomerooxygenase activity", "d": ["Catalysis of the reaction: Zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018684", "l": "2,5-diketocamphane 1,2-monooxygenase", "d": ["Catalysis of the reaction: 1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36583", "l": "dTDP-alpha-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23086", "l": "7-methyl-3-oxooct-6-enoyl-CoA + acetate => 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140901", "l": "L-asparagine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-asparagine(out) + Na+(out) = L-asparagine(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696268", "l": "RND3 binds effectors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41411", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine <=> 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73882", "l": "histamine(out) <=> histamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626817", "l": "PKC phosphorylates NCF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35304", "l": "3-hydroxyisopentadecanoyl-CoA + NADP(+) => 3-oxoisopentadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052749", "l": "glucose-6-phosphate dehydrogenase (coenzyme F420) activity", "d": ["Catalysis of the reaction: beta-D-glucose 6-phosphate + coenzyme F420 + H+ = 6-O-phosphono-D-glucono-1,5-lactone + reduced coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.22", "l": "\"NAD(+) diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733744", "l": "MESP1 binds the NKX2-5 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76031", "l": "2 H2O2 => O2 + 2 H2O (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418553", "l": "cAMP degradation by Phosphodiesterases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66500", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20699", "l": "2 H(+) + 2 superoxide <=> H2O2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49888", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132065", "l": "C1r activates C1s component within C1 complement complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033901", "l": "ribonuclease V activity", "d": ["Catalysis of the hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66266", "l": "diphosphate + nonanoyl-AMP => ATP + H(+) + nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43815", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191654", "l": "c-src associates with Cx43 in gap junctions (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61303", "l": "5-deoxy-D-ribulose 1-phosphate <=> acetaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74740", "l": "Binding of SHC1 to insulin receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.39", "l": "\"deuterolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47172", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) = 5alpha-cholest-8-en-3-one + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48345", "l": "an N-acyl-sphingoid base + UDP-alpha-D-galactose => a D-galactosylceramide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58736", "l": "H2O + TTP = 5-methyl-UMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50156", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375148", "l": "Interaction of NCAM1 with Neurocan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112271", "l": "The receptor:G-protein complex dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21679", "l": "2 dimethylallyl diphosphate <=> (R)-lavandulyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25349", "l": "D-tyrosine + tRNA(Tyr) => D-tyrosyl-tRNA(Tyr) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685519", "l": "Polyadenylation of SARS-CoV-1 genomic RNA (plus strand) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675790", "l": "MTORC1 dissociates from ULK complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39950", "l": "a 1,3-diacyl-sn-glycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691167", "l": "CUL1, SKP1, FBXL5 bind (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65555", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O <=> an N-acyl-sphingoid base + lactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849102", "l": "SRMS phosphorylates PTK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68043", "l": "(R)-lanthionine ketimine + 2 H(+) + NADPH <=> (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38556", "l": "an all-trans-retinyl ester + H2O => a fatty acid + all-trans-retinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36524", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + H(+) + malonyl-CoA => (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.3", "l": "\"uridine nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34027", "l": "3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) = (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013158", "l": "CDC42 GDIs block activation of CDC42 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10084", "l": "3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.3", "l": "\"protocatechuate 3,4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15087", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18382", "l": "dihydroxyacetone + phosphoenolpyruvate => dihydroxyacetone phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5660666", "l": "CBP and p300 binds NF-kB complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.12.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54700", "l": "4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73378", "l": "biotin(out) + 2 Na(+)(out) <=> biotin(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822467", "l": "KDM5A demethylates histone H3 trimethyllysine-4 (H3K4me3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47989", "l": "2-dehydro-3-deoxy-L-galactonate + NAD(+) => 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26480", "l": "a 2-demethylmenaquinol + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62648", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6794346", "l": "NRXNs bind NLGNs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52194", "l": "(Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + glutathione + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60288", "l": "N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.366", "l": "\"[histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050633", "l": "acetyl-CoA C-myristoyltransferase activity", "d": ["Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48320", "l": "a ganglioside GA1 + GDP-beta-L-fucose = a ganglioside Fuc-GA1 + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030770", "l": "demethylmacrocin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H+ + macrocin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49919", "l": "(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) <=> (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0052877", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and a copper protein is the acceptor."], "t": []}, {"i": "EC:1.4.9.-", "l": "\"With a copper protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047928", "l": "gibberellin beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0051448", "l": "gonadotropin-releasing hormone binding", "d": ["Binding to gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199154", "l": "CD200 binds to CD200R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847537", "l": "RAB43:GTP binds USP8NL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49058", "l": "asperlicin E + H2O + NADP(+) => asperlicin C + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21272", "l": "ATP + glutathione + spermidine = ADP + glutathionylspermidine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805620", "l": "KAT6A and PML bind TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051009", "l": "O-acetylhomoserine sulfhydrylase activity", "d": ["Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49864", "l": "(+)-dehydrodiconiferyl acid + 2 a quinone + H2O = (+)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871193", "l": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047446", "l": "(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity", "d": ["Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428779", "l": "GLUT7 and GLUT11 transport glucose and fructose (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68861", "l": "7-oxo-25-hydroxycholesterol + H(+) + NADPH => 7beta-25-dihydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4655374", "l": "SUMOylation of DNMT3B with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38071", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842648", "l": "Autophosphorylation of LTK dimer:ALKAL1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22950", "l": "D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate => D-tagatofuranose 1,6-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390425", "l": "FAR1 reduces PalmCoA to HXOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.109", "l": "\"endogalactosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67572", "l": "3'-phosphoadenylyl sulfate + alpha-muricholate = adenosine 3',5'-bisphosphate + alpha-muricholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465940", "l": "atRAL is reduced to atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60275", "l": "N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033802", "l": "isoliquiritigenin 2'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + isoliquiritigenin = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43755", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein uS5] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein uS5]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61213", "l": "myricetin + UDP-alpha-D-glucose => H(+) + myricetin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654222", "l": "Activated FGFR3 phosphorylates PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76796", "l": "2-aminopropan-1-ol + H2O + NAD(+) => H(+) + hydroxyacetone + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35565", "l": "(9Z)-hexadecenoate + ethanolamine => H2O + N-(9Z-hexadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21671", "l": "ATP + H2O + sn-glycerol 3-phosphate(out) <=> ADP + H(+) + phosphate + sn-glycerol 3-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0120230", "l": "recombinase activator activity", "d": ["Binds to and increases the activity of a recombinase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37121", "l": "2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe) => 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964773", "l": "OXGR1 binds 2OG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47636", "l": "H2O + L-arginine + NADP(+) = 5-guanidino-2-oxopentanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67870", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21611", "l": "isoliquiritigenin + S-adenosyl-L-methionine <=> 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57123", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030429", "l": "kynureninase activity", "d": ["Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56146", "l": "a quinone + H2O + nitrite => a quinol + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1112727", "l": "Serine phosphorylation of STATs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43788", "l": "acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate", "d": [], "t": []}, {"i": "EC:2.3.1.193", "l": "\"tRNA(Met) cytidine acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448480", "l": "IL22 binds IL22RA1:JAK1 receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23221", "l": "4-chlorobenzoate + ATP + CoA => 4-chlorobenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24594", "l": "CDP-ethanolamine + diphosphate => CTP + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72995", "l": "L-fucose(out) + 2 Na(+)(out) = L-fucose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685319", "l": "CX3 complex formation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66093", "l": "3-phenylpyruvate + L-kynurenine => H2O + kynurenate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28777", "l": "H(+) + H2O + hnu + oxidized dinoflagellate luciferin => dinoflagellate luciferin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034015", "l": "L-ribulose-5-phosphate 3-epimerase activity", "d": ["Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939323", "l": "RNF181 binds BCL10 and Ubiquitin:E2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34368", "l": "acrylamide + H2O => acrylate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.13.-", "l": "\"Protein-histidine kinases\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228941", "l": "Transcytosis and dissociation of botE:NTNHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59035", "l": "(Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693615", "l": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62654", "l": "6 CO2 + 7 CoA + H2O + naphtopyrone YWA1 => acetyl-CoA + 6 H(+) + 6 malonyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56820", "l": "AH2 + cyclooctat-9-en-7-ol + O2 = A + cyclooctat-9-ene-5,7-diol + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.61", "l": "\"cyclooctat-9-en-7-ol 5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57897", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + O2 => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50019", "l": "H2O + octanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44214", "l": "3-hydroxytetradecanoyl-CoA + AMP + diphosphate => 3-hydroxytetradecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13054", "l": "L-phenylalanine + pyruvate => 3-phenylpyruvate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31448", "l": "6-amino-2-oxohexanoate + H2O2 => 5-aminopentanoate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12767", "l": "acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39420", "l": "3-oxo-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16445", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone = daidzein + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16788", "l": "an adenosine in tRNA + S-adenosyl-L-methionine <=> an N(6)-methyladenosine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390909", "l": "HRH2 binds hist (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37299", "l": "H2O + L-alanyl-L-threonine = L-alanine + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684006", "l": "KPNA2 translocates NBN to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047110", "l": "phenylglyoxylate dehydrogenase (acylating) activity", "d": ["Catalysis of the reaction: CoA + NAD+ + phenylglyoxylate = benzoyl-CoA + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209925", "l": "DIT and MIT combine to form triiodothyronine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64066", "l": "(R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH => (1R,2R)-pseudoephedrine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34651", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine = 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72745", "l": "leukotriene C4(in) => leukotriene C4(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008098", "l": "5S rRNA primary transcript binding", "d": ["Binding to an unprocessed 5S ribosomal RNA transcript."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70364", "l": "cyanurate + H2O => 1-carboxybiuret + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23438", "l": "2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate => 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213017", "l": "Auto-ubiquitination of TRAF3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20799", "l": "aldehydo-D-ribose <=> D-ribulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809764", "l": "SBF1 binds MTMR2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73946", "l": "Abortive initiation after formation of the first phosphodiester bond (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64996", "l": "ATP + H(+) + octanoate = diphosphate + octanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42174", "l": "(8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O => (11Z)-eicosenoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77568", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-glycerol => 1,3-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.40", "l": "\"bleomycin hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41834", "l": "hexanoyl-[ACP] + NADP(+) => (2E)-hexenoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392513", "l": "Rap1 signal termination by Rap1GAPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41962", "l": "a ganglioside GA1 (d18:1(4E)) + H(+) + UDP => a ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15339", "l": "CoA + H(+) + phenylglyoxylate => H2O + phenylglyoxylyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29725", "l": "glyoxylate(out) => glyoxylate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050644", "l": "cis-p-coumarate glucosyltransferase activity", "d": ["Catalysis of the reaction: cis-4-coumarate + UDP-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63860", "l": "(9Z,12Z)-octadecadienoate + O2 = (2R,9Z,12Z)-2-hydroperoxyoctadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13276", "l": "3'-phosphoadenylyl sulfate + alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol <=> 6-sulfo-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl-(1->3)-1-alkyl-2-acylglycerol + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858729", "l": "MITF-M-dependent LIG1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112271", "l": "The receptor:G-protein complex dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15937", "l": "a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61819", "l": "16,17-didehydropregnenolone + UDP-alpha-D-glucose <=> 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046577", "l": "long-chain-alcohol oxidase activity", "d": ["Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193661", "l": "PRDM4 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090582", "l": "protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-fructose(out) = protein cysteine + D-fructose-1-phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2186771", "l": "RNF111 binds SMAD7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29469", "l": "H(+)(in) + K(+)(out) => H(+)(out) + K(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15663", "l": "an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA => (E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445087", "l": "CHL1 interacts with HSP7C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65610", "l": "CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + docosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12083", "l": "acetyl-CoA + H(+) + malonyl-[ACP] <=> 3-oxobutanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13411", "l": "7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH => 7-aminomethyl-7-carbaguanine + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035489", "l": "guanine/guanine mispair binding", "d": ["Binding to a double-stranded DNA region containing a G/G mispair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050299", "l": "streptomycin 3''-kinase activity", "d": ["Catalysis of the reaction: ATP + streptomycin = ADP + 2 H+ + streptomycin 3''-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9725855", "l": "NR3C2 binds NR3C2 antagonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25934", "l": "4-methylquinolin-2(1H)-one + AH2 => 4-methylquinoline + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18738", "l": "ATP + H2O + hydrogenselenide => AMP + 2 H(+) + phosphate + selenophosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77585", "l": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428127", "l": "SPTLC complexes transfer acyl-CoA onto serine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193964", "l": "CYP21A2 21-hydroxylates PROG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30459", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol = (1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + acetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23744", "l": "2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.9", "l": "\"histidinol-phosphate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19874", "l": "dehydroepiandrosterone 3-sulfate + H2O => 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022919", "l": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170672", "l": "Galpha-olf:GTP binds to adenylate cyclase and activates it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46650", "l": "androst-4-ene-3,17-dione + propanoyl-CoA => 17-hydroxy-3-oxochol-4-en-22-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36029", "l": "H(+) + NADH + propanoyl-CoA => CoA + NAD(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44375", "l": "Cr(6+) + 2 NADH + O2 <=> Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088281", "l": "Endorepellin binds KDR (VEGFR2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202969", "l": "Caspase mediated cleavage of beta-catenin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030274", "l": "LIM domain binding", "d": ["Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4608855", "l": "PRICKLE1 is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67190", "l": "ADP + H(+) + N-all-trans-retinylidenephosphatidylethanolamine(in) + phosphate => ATP + H2O + N-all-trans-retinylidenephosphatidylethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44602", "l": "a fatty acyl-AMP + diphosphate => a fatty acid + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097677", "l": "STAT family protein binding", "d": ["Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9844860", "l": "ST3GAL5 transfers NeuNAc to ceramides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43110", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide => 2 Fe(III)-[cytochrome c] + H2O + N2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629918", "l": "NEIL1 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433501", "l": "Interaction of other adapter proteins with p-KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570573", "l": "Defective RFT1 does not flip the N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29640", "l": "D-maltohexaose + H2O => alpha-D-glucose + D-maltopentaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050402", "l": "xylono-1,4-lactonase activity", "d": ["Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13908", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42832", "l": "(2E)-octenal + H(+) + pyruvate = (S)-3-acetyloctanal + CO2", "d": [], "t": []}, {"i": "EC:2.2.1.12", "l": "\"3-acetyloctanal synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61554", "l": "gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769401", "l": "DKK and KRM bind LRP5/6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49077", "l": "dibenzothiophene + FMNH2 + O2 => dibenzothiophene 5-oxide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21814", "l": "7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811412", "l": "Active ARF recruits coatomer to the Golgi (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.360", "l": "\"glucose/galactose 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2559439", "l": "CD14:LPS binds CR3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050268", "l": "coniferyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42950", "l": "5-methylcytidine(48) in tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197770", "l": "STAB1 (FEEL-1) binds ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134962", "l": "DHX36 binds DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57981", "l": "(20S)-protopanaxatriol + UDP-alpha-D-glucose => (20S)-ginsenoside F1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62114", "l": "H2O + iminosuccinate => (3S)-3-hydroxy-D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58276", "l": "6 ATP = cyclic hexaadenylate + 6 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65075", "l": "(2E,6E)-farnesyl diphosphate <=> dauca-4,7-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322429", "l": "XIAP monoubiquinates TLE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647980", "l": "mature RAS proteins translocate to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33973", "l": "phosphate + ribostamycin => 5''-phosphoribostamycin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62752", "l": "H2O + pravastatin lactone = (S)-2-methylbutanoate + H(+) + pravastatin diol lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004561", "l": "alpha-N-acetylglucosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72534", "l": "ATP + H2O + methyl beta-D-galactoside(out) <=> ADP + H(+) + methyl beta-D-galactoside(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33990", "l": "(+)-copalyl diphosphate <=> diphosphate + neoabietadiene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48616", "l": "H2O + leukotriene D4 = glycine + leukotriene E4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11385", "l": "(S)-2-hydroxyoctadecanoate + NAD(+) => 2-oxooctadecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350604", "l": "Agmatine + H2O <=> putrescine + urea (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-447219", "l": "IL17RA and IL17RB bind IL25 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64064", "l": "(1R,2R)-pseudoephedrine + NAD(+) = (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141180", "l": "dsDNA-RNA triple helix-forming chromatin adaptor activity", "d": ["A chromatin-protein adaptor activity that bridges dsDNA and chromatin proteins to bring regions of a chromosome in proximity. The DNA:DNA:RNA triple-helical structure is formed non-Watson-Crick base-pairing."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3769401", "l": "DKK and KRM bind LRP5/6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63341", "l": "ATP + L-amino acyl-L-seryl-[protein] => (S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770145", "l": "Formation of the Spliceosomal Bact complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62177", "l": "GDP-alpha-D-glucose + H2O => alpha-D-glucose 1-phosphate + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69424", "l": "2-hydroxyisobutanoyl-CoA = acetone + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800001", "l": "TP53 family members stimulate FAS gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641147", "l": "DACT1 binds DVL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851038", "l": "BTN3A1 binds prenylated phosphoantigens (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74712", "l": "Dissociation of IRS-P from insulin receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162192", "l": "COQ2 ligates all-E-10PrP2 to PHB (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19658", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NADP(+) => CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-879942", "l": "The receptor is activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44967", "l": "(2E)-dodecenoyl-CoA + H(+) + NADPH <=> dodecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47780", "l": "a cytidine in 25S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13045", "l": "ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] = ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38028", "l": "(E)-caffeate + hydrocaffeoyl-CoA => (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189102", "l": "maltose + H2O => 2 D-glucose (maltase-glucoamylase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730835", "l": "Autophosphorylation of PKC-theta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380157", "l": "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51575", "l": "(25S)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25S)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33853", "l": "GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine => GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28078", "l": "2-hydroxyethylphosphonate + NAD(+) = H(+) + NADH + phosphonoacetaldehyde", "d": [], "t": []}, {"i": "EC:1.1.1.309", "l": "\"phosphonoacetaldehyde reductase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25374", "l": "(2S)-2-amino-4-deoxychorismate + FMN <=> 3-(1-carboxyvinyloxy)anthranilate + FMNH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41889", "l": "3-oxotetradecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047149", "l": "thetin-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: L-homocysteine + dimethylsulfonioacetate = (methylthio)acetate + L-methionine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047525", "l": "2'-hydroxydaidzein reductase activity", "d": ["Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60211", "l": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 <=> 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73692", "l": "3'-AMP(out) + phosphate(in) => 3'-AMP(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62909", "l": "nor-toralactone + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + toralactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13467", "l": "CoA + N(3)-oxalyl-L-2,3-diaminopropanoate => (S)-2,3-diaminopropanoate + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44283", "l": "2 H(+) + 2 malonyl-CoA + octadecanoyl-CoA <=> 4-hydroxy-6-heptadecylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33745", "l": "an N-acylsphing-4-enine + phosphate => an N-acylsphing-4-enine 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0051723", "l": "protein methylesterase activity", "d": ["Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol."], "t": []}, {"i": "REACT:R-HSA-5367022", "l": "DPH7 hydrolyzes a methyl group on Me-diphthine EEF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806629", "l": "Formation of tonofilament bundles (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950732", "l": "Expression of Macrophage migration inhibitory factor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983700", "l": "SYK binds the activated BCR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689649", "l": "BAP1 binds BRCA1:BARD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48504", "l": "D-glycero-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-D-manno-heptose 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72109", "l": "Na(+)(in) + O-acyl-(R)-carnitine(in) => Na(+)(out) + O-acyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25681", "l": "ATP + O-phospho-L-serine + tRNA(Cys) <=> AMP + diphosphate + O-phospho-L-seryl-tRNA(Cys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186780", "l": "PI3-kinase binds to the active receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685608", "l": "CLEC2B binds KLRF1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9838081", "l": "LONP1 degrades mitochondrial matrix proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879914", "l": "IL3 stimulation induces Vav binding to Tec kinase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66562", "l": "5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+) => (R)-noradrenaline + L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44111", "l": "H2O + heptanal + NAD(+) <=> 2 H(+) + heptanoate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670417", "l": "Dimerization of STATs downstream of KIT mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44962", "l": "decanoyl-CoA + NADP(+) => (2E)-decenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59580", "l": "hexadecanoyl-CoA + N-terminal L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester = CoA + H(+) + N-terminal N-hexadecanoyl-L-cysteinyl-[protein]-C-terminal glycyl cholesterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39549", "l": "(2E,21Z,24Z,27Z,30Z,33Z)-hexatriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.63", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632858", "l": "PRKCZ autophosphorylates downstream of estrogen stimulation (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44996", "l": "(R)-carnitine + acetoacetyl-CoA = CoA + O-3-oxobutanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022869", "l": "protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9825790", "l": "p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1181153", "l": "Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46481", "l": "4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18196", "l": "H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] <=> (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54660", "l": "an aromatic (S)-hydroxynitrile = an aromatic aldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44043", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O <=> 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38603", "l": "NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49790", "l": "CoA + glycochenodeoxycholate + H(+) => chenodeoxycholoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371518", "l": "SIRT1 binds to HSF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604763", "l": "Autocatalytic activation of MMP7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39304", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA => (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71040", "l": "L-methionine(in) + L-phenylalanine(out) => L-methionine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49311", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O <=> a neolactoside nLc4Cer(d18:0) + L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67943", "l": "2-hydroxyoctanoate + O2 <=> 2-oxooctanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050595", "l": "7-deoxyloganin 7-hydroxylase activity", "d": ["Catalysis of the reaction: 7-deoxyloganin + O2 + reduced [NADPH-hemoprotein reductase] = H+ + H2O + loganin + oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61315", "l": "germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71674", "l": "glycyl-L-glutamine(out) + H(+)(out) <=> glycyl-L-glutamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694727", "l": "Endocytosis of protein 3a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770187", "l": "S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449811", "l": "IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12834", "l": "an N-acyl-D-glutamate + H2O => a carboxylate + D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51083", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2484822", "l": "Kinetochore assembly (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607734", "l": "PKC-delta translocates to plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782264", "l": "CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64451", "l": "L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786171", "l": "FANCD2 deubiquitination by USP1:WDR48 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014433", "l": "RHOG GEFs activate RHOG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44502", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+) => 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160147", "l": "tRNA pseudouridine(38-40) synthase activity", "d": ["Catalysis of the reaction: uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37383", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132261", "l": "Complement factor H binds to C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112266", "l": "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.103", "l": "\"keratan-sulfate endo-1,4-beta-galactosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67260", "l": "(E)-hept-2-enal + H2O + NAD(+) = (E)-hept-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917807", "l": "holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78002", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol <=> a 1-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22022", "l": "ADP + H(+) + molybdate(in) + phosphate => ATP + H2O + molybdate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870461", "l": "RABGGTA and RABGGTB bind (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11836", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-beta-lactosamine = CMP + H(+) + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24640", "l": "ergosteryl 3-beta-D-glucoside + H2O = D-glucose + ergosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.12", "l": "\"N-acetylgalactosamine-4-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050037", "l": "L-xylose 1-dehydrogenase activity", "d": ["Catalysis of the reaction: L-xylose + NADP+ = H+ + L-xylono-1,4-lactone + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13583", "l": "H(+) + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP => N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084903", "l": "Collagen types VI, IX bind integrin alpha10beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730904", "l": "Auto-ubiquitination of TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.185573331668621", "identifiers": [{"i": "GO:0004536", "l": "DNA nuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9695890", "l": "SPNS2,MFSD2B transport S1P from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17800", "l": "[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose <=> [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682586", "l": "HERC2 and PIAS4 are recruited to DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61786", "l": "keto-L-fructose => L-allulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35670", "l": "a triacylglycerol + H2O <=> a 1,2-diacylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18814", "l": "(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate => (3E,5R)-5-carboxy-2-oxohept-3-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2309787", "l": "Arachidonic acid is oxidised to PGG2 by PTGS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26040", "l": "beta-D-fructose 6-phosphate + GDP-alpha-D-mannose => beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2064421", "l": "YAP1 binds ZO-2 (TJP2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76754", "l": "5-hydroxydodecanoate + H(+) <=> delta-dodecalactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202947", "l": "Caspase mediated cleavage of APC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759496", "l": "CDH11 nascent mRNA is spliced into the canonical splicing isoform (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166538", "l": "The bound receptor dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213239", "l": "Formation of MHC II alpha beta heterodimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23680", "l": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.15", "l": "\"nucleoside-triphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874198", "l": "CREB3L2 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33589", "l": "CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate => acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730833", "l": "Phosphorylation of TEC kinases by p-SYK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28751", "l": "sn-glycerol 3-phosphate + ubiquinone-8 = dihydroxyacetone phosphate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010177", "l": "2-(2'-methylthio)ethylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-4-methylthiobutanoate + acetyl-CoA + H2O = 2-(2'-methylthio)ethylmalic-acid + coenzyme A + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49300", "l": "D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] = alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.208", "l": "\"protein-N(pi)-phosphohistidine--maltose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78974", "l": "(2E)-3-methyl-5-phosphooxypent-2-enoate + H(+) <=> CO2 + isopentenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25101", "l": "ATP + UDP <=> ADP + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005212", "l": "structural constituent of eye lens", "d": ["The action of a molecule that contributes to the structural integrity of the lens of an eye."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850040", "l": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445753", "l": "IL1B,Myr82K-Myr83K-IL1A:IL1R1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21844", "l": "L-glutamine + phenylacetyl-CoA = CoA + H(+) + N(2)-phenylacetyl-L-glutamine", "d": [], "t": []}, {"i": "EC:2.3.1.14", "l": "\"glutamine N-phenylacetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40818", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391939", "l": "TP receptor can bind thromboxane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54128", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48162", "l": "epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78265", "l": "9-cis-retinyl ester + CoA => 9-cis-retinol + a fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16495", "l": "glycerol 1-phosphate + H(+) => glycerol 1,2-cyclic phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33012", "l": "(+)-artemisinic aldehyde + O2 + reduced [NADPH--hemoprotein reductase] => (+)-artemisinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203979", "l": "Coat Assembly (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10776", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12120", "l": "alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.27", "l": "\"glucose-1-phosphate adenylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77301", "l": "3,7-dimethylurate + a ubiquinol => a ubiquinone + H2O + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669023", "l": "TWEAK binds FN14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51276", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975119", "l": "NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6799332", "l": "ATR phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52294", "l": "13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192123", "l": "CYP27A1 27-hydroxylates CHOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71644", "l": "guanosine + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682967", "l": "WHSC1 binds DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654515", "l": "KAL1 binds HS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.52", "l": "\"phosphoserine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848338", "l": "PNPLA4 hydrolyzes TAG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75172", "l": "Formation of RAD50:MRE11 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66874", "l": "9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.137", "l": "\"2-acyl-4-prenylphloroglucinol 6-prenyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37080", "l": "2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine => 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51218", "l": "adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate + H(+) => 3'-phosphoadenylyl sulfate + 3beta-hydroxyandrost-5-en-17-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33777", "l": "1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+) => a 1,2-diacyl-sn-glycerol + CDP-N,N-dimethylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9637589", "l": "MmpL7 transports PDIM from the cytosol to the cell wall (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75659", "l": "(11Z,14Z)-eicosadienoate + O2 = 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9029987", "l": "p-S216-CDC25C translocates to the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140599", "l": "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019191", "l": "cellobiose transmembrane transporter activity", "d": ["Enables the transfer of cellobiose from one side of a membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428205", "l": "ACER2 hydrolyzes ceramide (Golgi) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20163", "l": "myo-inositol + raffinose => alpha-D-galactosyl-(1->3)-1D-myo-inositol + sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199425", "l": "PHLPP dephosphorylates S473 in AKT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63901", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) => (2S)-2-(4-hydoxybenzyl)-3-(4-hydroxyphenyl)-2-furonol carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050201", "l": "fucokinase activity", "d": ["Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5631941", "l": "SESN1,2,3 bind AMPK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693125", "l": "RHOF binds effectors at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432946", "l": "PARVB/Affixin interacts with alpha PIX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5205649", "l": "p62 links damaged mitochondria to LC3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691154", "l": "HFE binds TFRC dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61626", "l": "5-aminopentanal + L-glutamate => 2-oxoglutarate + cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0061785", "l": "peptidoglycan endopeptidase activity", "d": ["An endopeptidase activity that uses peptidoglycan as a substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-167415", "l": "G-protein alpha subunit is inactivated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63210", "l": "5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O => 5-amino-6-(D-ribitylamino)uracil + glyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73278", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine <=> 4',7,8-trihydroxy-3'-methoxyflavone-7-olate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102666", "l": "indole-3-acetyl-beta-4-D-glucose hydrolase activity", "d": ["Catalysis of the reaction: indole-3-acetyl-beta-4-D-glucose + H2O = H+ + indole-3-acetate + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33458", "l": "4alpha-carboxyzymosterol + NADP(+) <=> CO2 + NADPH + zymosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40866", "l": "FAD + H(+) + heptadecanoyl-CoA <=> FADH2 + trans-2-heptadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47295", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46560", "l": "episterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5607746", "l": "PKC-delta is activated (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111879", "l": "PIP2 hydrolysis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77410", "l": "2,2-dimethylpropanal + hydrogen cyanide <=> (2S)-2-hydroxy-3,3-dimethylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9853512", "l": "DLST transfers succinyl to CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55148", "l": "a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) = a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2562541", "l": "TLR4-induced ripoptosome assembly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27694", "l": "(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692738", "l": "HRH2 binds HRH2 antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77058", "l": "cyclopentylamine + H2O + NADP(+) <=> cyclopentanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73331", "l": "(2R,3S)-piscidate + (E)-feruloyl-CoA = cimicifugate E + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166220", "l": "FA anion diffuses laterally to UCP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018726", "l": "9-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62463", "l": "3,4-dihydroxybenzoate + ATP + holo-[aryl-carrier protein] <=> 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9656891", "l": "OPN1SW binds 11cRAL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65261", "l": "verruculide C epoxide => 3-hydroxypentacecilide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65079", "l": "dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9629918", "l": "NEIL1 translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9842648", "l": "Autophosphorylation of LTK dimer:ALKAL1,2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684261", "l": "MAP3K8 is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21390", "l": "L-lysine => H2O + L-2-aminohexano-6-lactam", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24241", "l": "A + AMP + 2 H(+) + sulfite => adenosine 5'-phosphosulfate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66486", "l": "16alpha-hydroxygypsogenate 28-beta-D-glucoside + UDP => 16alpha-hydroxygypsogenate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134954", "l": "DHX9 binds DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693533", "l": "DCLRE1C (ARTEMIS) processes DNA DSB ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27996", "l": "D-ribose + xanthine => H2O + xanthosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36590", "l": "an aldopyranose + NADP(+) <=> aldono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44677", "l": "a triacylglycerol + all-trans-retinol => a diacylglycerol + an all-trans-retinyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11281", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP + H2O => (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyl-dCMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428625", "l": "Vesicular inhibitory amino acid transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33006", "l": "(+)-amorpha-4,11-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinic alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22134", "l": "ADP + D-maltose(in) + H(+) + phosphate => ATP + D-maltose(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29529", "l": "a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0062105", "l": "RNA 2'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + RNA = S-adenosyl-L-homocysteine + RNA containing 2'-O-methylribonucleotide."], "t": []}, {"i": "RHEA:58956", "l": "a ribonucleotide in RNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65229", "l": "(1S,2S)-1,2-dihydronaphthalene-1,2-diol + NADP(+) => H(+) + NADPH + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603437", "l": "Activated NTRK3 binds IRS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39537", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H2O => (3R)-hydroxy-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71713", "l": "H(+)(in) + L-tyrosylglycine(in) => H(+)(out) + L-tyrosylglycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351207", "l": "Spermine  => N-acetylated spermine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37249", "l": "phosphate + thymidine => H2O + thymidine 3'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8934742", "l": "RUNX1 binds PRMT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001608", "l": "G protein-coupled nucleotide receptor activity", "d": ["Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2197690", "l": "Detachment of WASP/WAVE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13197", "l": "H(+) + sulfite + UDP-alpha-D-glucose = H2O + UDP-alpha-D-6-sulfoquinovose", "d": [], "t": []}, {"i": "EC:3.13.1.1", "l": "\"UDP-sulfoquinovose synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632412", "l": "PTK2 is recruited to methylated ESR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9853878", "l": "FIGNL1 binds DMC1, RAD51 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794414", "l": "Basolateral transport of Cipro to extracellular space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62676", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide = 6-thio-IMP + 7,8-dihydrofolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806425", "l": "TP53 stimulates FANCC expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684140", "l": "ATM phosphorylates RBBP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55569", "l": "4-hydoxytryptamine 4-phosphate + 2 S-adenosyl-L-methionine => 2 H(+) + psilocybin + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59823", "l": "2 ATP <=> adenosine 3'-diphosphate,5'-triphosphate + AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203613", "l": "depalmitoylation of eNOS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31542", "l": "(2S)-naringenin + S-adenosyl-L-methionine <=> (2S)-sakuranetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654157", "l": "p-4Y-PLCG1 dissociates from activated FGFR2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22926", "l": "dUMP + NH4(+) => dCMP + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46533", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67006", "l": "a 5'-end diphospho-ribonucleoside in mRNA + H(+) + phosphate => a 5'-end triphospho-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38057", "l": "CDP + H(+) + phytyl phosphate => CTP + phytol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482533", "l": "2-acyl LPC is acylated to PC by LPCAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72286", "l": "a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) <=> a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086410", "l": "CDK1 phosphorylates BORA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48761", "l": "L-threitol + NAD(+) => H(+) + L-erythrulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106332", "l": "ds/ssDNA junction-specific dsDNA endonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of double-stranded DNA near a double-strand/single-strand DNA junction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32976", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56293", "l": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] => 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55222", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193099", "l": "CYP17A1 cleaves 17aHPROG to ANDST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56486", "l": "gypsogenate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 3 O2 + oleanolate + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79013", "l": "diphosphate + ent-beyerene => ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45109", "l": "(+)-alpha-tocopherol + O2 + reduced [NADPH--hemoprotein reductase] => 13-hydroxy-alpha-tocopherol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9680865", "l": "CYP3A4, CYP2B6 bind ritonavir (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60619", "l": "N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine <=> ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28670", "l": "H(+) + hydroxyacetone + NADH <=> (S)-propane-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13774", "l": "(S)-cheilanthifoline + O2 + reduced [NADPH--hemoprotein reductase] => (S)-stylopine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264458", "l": "Proteasome mediated degradation of COP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63722", "l": "losartan-2-N-beta-D-glucuronide + UDP => losartan + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31017", "l": "CO2 + indole => H(+) + indole-3-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54875", "l": "(1S,4R)-menthone + H(+) + NADPH + O2 <=> (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018895", "l": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11130", "l": "2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA => 4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27345", "l": "FMNH2 + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate + H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.79", "l": "\"aerobic 5,6-dimethylbenzimidazole synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944454", "l": "mTORC1 phosphorylates MAF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42535", "l": "uridine(55) in tRNA <=> pseudouridine(55) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67475", "l": "H2O + succinyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102864", "l": "1-18:3-2-18:2-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41433", "l": "3-methyl-L-tyrosine + H2O2 => 5-hydroxy-3-methyl-L-tyrosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53267", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2beta-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009485", "l": "IL34:CSF1 binds CSF1R (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71793", "l": "(R)-lactate(out) + H(+)(out) => (R)-lactate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-481044", "l": "Surface deployment of platelet alpha granule membrane components (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877281", "l": "PIAS1 binds p-STAT1 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141040", "l": "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14824", "l": "beta-L-arabinopyranose <=> L-ribulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22912", "l": "L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine", "d": [], "t": []}, {"i": "EC:2.6.1.66", "l": "\"valine--pyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35374", "l": "2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) <=> (beta-L-Ara4N)2-(Kdo)2-lipid A + 2 di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71985", "l": "diphosphate + fusoxypene B => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517705", "l": "p-S318,221-HuR binds mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418925", "l": "ADORA2A,B bind Ade-Rib (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214395", "l": "Monomeric PGN bound PGRP-LE oligomerises in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607751", "l": "TRAF6 oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58182", "l": "all-trans-lycopaoctaene + diphosphate + NADP(+) => (1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817575", "l": "ERO1B oxidizes P4HB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48741", "l": "[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + O-phospho-L-serine => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75948", "l": "L-arginine + taurine => L-ornithine + taurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047862", "l": "diisopropyl-fluorophosphatase activity", "d": ["Catalysis of the reaction: diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36325", "l": "(9Z)-octadecen-1-ol + CoA + 2 NADP(+) => (9Z)-octadecenoyl-CoA + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48488", "l": "all-trans-retinol--[retinol-binding protein] + NAD(+) = all-trans-retinal--[retinol-binding protein] + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38458", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75104", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 32-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61150", "l": "H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP => myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156912", "l": "Peptide transfer from P-site tRNA to the A-site tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14671", "l": "(2R)-3-phosphoglycerate + 2 H(+) + NADPH => D-glyceraldehyde 3-phosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33881", "l": "3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH => 2-deoxy-scyllo-inosamine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22206", "l": "H2O + homogentisate + NADP(+) => 3-hydroxyphenylacetate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54102", "l": "H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18651", "l": "2-dehydro-3-deoxy-D-galactonate + H2O => D-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78519", "l": "H2O + N-acetyl-2,7-anhydro-alpha-neuraminate = N-acetyl-alpha-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429699", "l": "CERT1-2 complex binds ceramide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45730", "l": "(E)-caffeyl aldehyde + H(+) + NADPH => (E)-caffeyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-186798", "l": "GAP binds to PDGF-beta receptors only (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23254", "l": "[thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate => [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74742", "l": "Phosphorylation of SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55757", "l": "2-oxoglutarate + an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + O2 => a 2-hydroxyornithine lipid + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684248", "l": "SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4411402", "l": "Activation of NLK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-606349", "l": "Mis18 complex binds the centromere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48589", "l": "2 H2O + 2 leukotriene A4 + O2 => 2 lipoxin B4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1454928", "l": "ABCG4 may mediate cholesterol efflux (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0016415", "l": "octanoyltransferase activity", "d": ["Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52441", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose => a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48811", "l": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 <=> (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61571", "l": "an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022894", "l": "intermediate conductance calcium-activated potassium channel activity", "d": ["Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40400", "l": "1,2-dihydro-beta-NADP + H(+) + O2 => H2O2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54429", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O => ADP-D-ribose + H(+) + L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78079", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = a 1-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-179421", "l": "Degradation of multiubiquitinated Nek2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047413", "l": "N(alpha)-benzyloxycarbonylleucine hydrolase activity", "d": ["Catalysis of the reaction: N-benzyloxycarbonyl-L-leucine + H2O + H+ = L-leucine + benzyl alcohol + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9734670", "l": "ORC6 binds KPNA1 or KPNA6 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40495", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine + O2 = N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193774", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38203", "l": "19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46127", "l": "(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433374", "l": "Processing of SCF isoform 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250463", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.98", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901973", "l": "proline binding", "d": ["Binding to proline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70609", "l": "glutamine + H2O => glutamate + NH4+ [GLS] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57596", "l": "(S)-eriodictyol + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxyeriodictyol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48946", "l": "3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871226", "l": "RET binds GFRA1,GFRA2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46761", "l": "2,4-dinitrotoluene + NADH + O2 => 4-methyl-5-nitrocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76466", "l": "CYP4A11 12-hydroxylates DDCX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018807", "l": "RAC3 GDIs block activation of RAC3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050195", "l": "phosphoribokinase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + ATP = D-ribose 1,5-diphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692376", "l": "BCL2 binds BCL2 antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874849", "l": "CREBRF binds CREB3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690785", "l": "BAP1 binds Ub-HCFC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17463", "l": "D-sedoheptulose 7-phosphate + phosphate => D-sedoheptulose 1,7-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35832", "l": "2-oxoglutarate + kanamycin B + O2 => 2'-dehydrokanamycin A + CO2 + NH4(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41723", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31650", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O <=> 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0106359", "l": "2-hydroxyacyl-CoA lyase activity", "d": ["Catalysis of the reaction: a 2-hydroxy fatty acyl-CoA = a fatty aldehyde + formyl-CoA. The reaction acts on 2-hydroxy-3-methyl-branched fatty acyl-CoA and 2-hydroxy-long-chain fatty acyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56011", "l": "4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) <=> 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48339", "l": "a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34860", "l": "3-oxocyclopentanecarbonitrile + 2 H2O => 3-oxocyclopentanecarboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004377", "l": "GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity", "d": ["Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25867", "l": "H2O + N(1)-acetylspermidine + O2 <=> 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19136", "l": "2-oxoglutarate + 3,3',5-triiodo-L-thyronine <=> 3,5,3'-triiodothyropyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140761", "l": "sequestered tissue factor -> tissue factor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71867", "l": "glycodeoxycholate(out) = glycodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050897", "l": "cobalt ion binding", "d": ["Binding to a cobalt ion (Co2+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660192", "l": "VDR agonists bind VDR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874082", "l": "MET phosphorylates PTK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13688", "l": "lathosterol + NADP(+) <=> 5alpha-cholesta-7,24-dien-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60748", "l": "(1R,3R)-pyrethroyl-CoA + (Z,S)-pyrethrolone = CoA + pyrethrin II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0050735", "l": "N-malonyltransferase activity", "d": ["Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44372", "l": "Cr(6+) + 2 NADH + O2 = Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140830", "l": "L-glutamine, sodium:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-glutamine(out) + Na+(out) = H+(out) + L-glutamine(in) + Na+(in)."], "t": []}, {"i": "RHEA:71127", "l": "H(+)(in) + L-glutamine(out) + Na(+)(out) = H(+)(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065357", "l": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9658253", "l": "RAS:GTP binds PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36437", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(out) => a 1,2-diacyl-sn-glycero-3-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008766", "l": "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity", "d": ["Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42819", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol <=> cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604264", "l": "ADAM10 cleaves NOTCH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63640", "l": "H2O + N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NAD(+) = 2''-O-lipoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}, {"i": "EC:2.3.1.313", "l": "\"NAD-dependent lipoamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14378", "l": "(3R)-3-hydroxy-L-aspartate => glycine + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29992", "l": "H(+)(in) + L-lyxopyranose(in) => H(+)(out) + L-lyxopyranose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23398", "l": "1,3,5-trihydroxybenzene + H(+) + phloretate => H2O + phloretin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044547", "l": "DNA topoisomerase binding", "d": ["Binding to a DNA topoisomerase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989756", "l": "Expression of ME1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39724", "l": "a 1,2-diacyl-sn-glycerol(in) => a 1,2-diacyl-sn-glycerol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008196", "l": "vitellogenin receptor activity", "d": ["Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57492", "l": "H2O + oxaloacetate + propanoyl-CoA = 2-methylcitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38647", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65414", "l": "dAMP(out) + NAD(+)(in) => dAMP(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.198", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956025", "l": "AcM-UBE2M transfers NEDD8 to CUL9:RBX1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.147", "l": "\"16alpha-hydroxysteroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781011", "l": "EPM2A dimer dephosphorylates phosphoglycogen-GYG2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43228", "l": "L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674385", "l": "p-T,Y MAPKs dimerize (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69141", "l": "N-(4-aminobutyl)-3-aminopropanal => acrolein + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44820", "l": "1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-13 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34309", "l": "2-hydroxy-1,4-benzoquinone + H2O + NADP(+) + nitrite => 4-nitrocatechol + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18567", "l": "9 CO2 + 9 CoA + dihydromonacolin L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-homocysteine => 19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102949", "l": "1,2-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: isoorientin + an L-rhamonsylated rhamnosyl acceptor = isoorientin 2'-O-rhamnoside + a non rhamnosylated rhamnosyl acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6795290", "l": "TORC2 complex phosphorylates SGK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17096", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33631", "l": "ATP + CoA + octanoate = AMP + diphosphate + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602377", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[15] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73722", "l": "3,4-dihydroxybenzoate + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029476", "l": "Role of myosins in phagosome formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48953", "l": "14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) => 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25411", "l": "ADP-alpha-D-glucose + D-glucose <=> ADP + alpha,alpha-trehalose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38485", "l": "a 2-acylglycerol + a fatty acid + H(+) => a 2,3-diacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13356", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol <=> 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75303", "l": "NAD(+) = 3'cADPR + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47418", "l": "a ribonucleoside 5'-diphosphate + alpha,alpha-trehalose + H(+) => an NDP-alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944255", "l": "Association of procollagen type VII (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28768", "l": "ethylnitronate + O2 => acetaldehyde + chemical entity + H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30855", "l": "dammarenediol-II = (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.125", "l": "\"dammarenediol II synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.3.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16759", "l": "H(+) + NADPH + trypanothione disulfide => NADP(+) + trypanothione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25565", "l": "H2O + N-acetyl-4-O-acetylneuraminate => acetate + H(+) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69084", "l": "acrolein + H2O + NAD(+) = acrylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72842", "l": "ADP(out) + CoA(in) <=> ADP(in) + CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46235", "l": "(9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-418553", "l": "cAMP degradation by Phosphodiesterases (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50489", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10989", "l": "H2O + nitrous oxide => 2 e(-) + 2 H(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53823", "l": "chenodeoxycholate + NADP(+) <=> 7-oxolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42783", "l": "adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine <=> 4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029456", "l": "RAC1 and CDC42 activate PAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822311", "l": "CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008984", "l": "protein-glutamate methylesterase activity", "d": ["Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9854315", "l": "CSKMT methylates Citrate Synthase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24531", "l": "(R)-lactaldehyde + NAD(+) <=> H(+) + methylglyoxal + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446221", "l": "GMPPB converts Mannose-1-phosphate to GDP-Mannose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71632", "l": "phosphate(in) + sulfate(out) => phosphate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78464", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose => an isogloboside iGb3Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72050", "l": "A + D-alanine + D-allo-threonine + D-leucine + 2 L-leucine + L-proline <=> AH2 + fusahexin + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450400", "l": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730903", "l": "Oligomerization of TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621354", "l": "CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26428", "l": "ADP + CTP + 2 H(+) + L-glutamate + phosphate => ATP + H2O + L-glutamine + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26398", "l": "all-trans-zeaxanthin + 2 O2 => 2 3beta-hydroxy-beta-cyclocitral + crocetin dialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9024326", "l": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71878", "l": "2 Na(+)(out) + taurocholate(out) <=> 2 Na(+)(in) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39691", "l": "(2E,11Z)-octadecadienoyl-CoA + H(+) + NADPH = (11Z)-octadecenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102273", "l": "homophytochelatin synthase (dimmer forming) activity", "d": ["Catalysis of the reaction: glutathionate + L-gamma-glutamyl-L-cysteinyl-beta-alaninate = gamma-Glu-Cys-gamma-Glu-Cys-beta-Ala + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29264", "l": "L-leucine(in) + Na(+)(in) => L-leucine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38026", "l": "gamma-tocotrienol <=> 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13665", "l": "GTP = 3',5'-cyclic GMP + diphosphate", "d": [], "t": []}, {"i": "EC:4.6.1.2", "l": "\"guanylate cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052816", "l": "long-chain fatty acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}, {"i": "RHEA:67680", "l": "a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080133", "l": "midchain alkane hydroxylase activity", "d": ["Catalysis of the conversion of an alkane to a secondary alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39850", "l": "a 2-acylglycerol + ATP <=> a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65578", "l": "an alpha-D-glucuronosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + H(+) + UDP => a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59370", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + 10-hydroxyoctadecanoate + H(+) => 1-octadecanoyl-2-(10-hydroxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010647", "l": "ROBO3.1 binds AKAP5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650447", "l": "SERPING1 variant is not secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33969", "l": "3-maleylpyruvate + H(+) => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59475", "l": "2',3'-cGAMP + H2O <=> Gp(2'-5')Ap(3') + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32901", "l": "2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin] => 1,8-cineole + O2 + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77353", "l": "(2S)-2-aminobutanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate => 2-oxobutanoate + N(omega),N(omega)-dimethyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68408", "l": "(2R,3S)-iso(homo)3citrate + NAD(+) = 2-oxosuberate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2029473", "l": "Branching and elongation of mother and daughter filaments (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47712", "l": "trans-3-hydroxy-L-proline = cis-3-hydroxy-D-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9651280", "l": "RAS GAP mutants aren't stimulated by GAPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195378", "l": "Homodimerization of VEGF proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.337", "l": "\"L-2-hydroxycarboxylate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72460", "l": "fumarate(in) + L-aspartate(out) => fumarate(out) + L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141098", "l": "tRNA (cytidine(34)-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34867", "l": "ATP + CoA + thiophene-2-carboxylate = AMP + diphosphate + thiophene-2-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627089", "l": "CASP9 is phosphorylated at T412 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72273", "l": "formate(in) + oxalate(out) => formate(out) + oxalate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79088", "l": "an L-alpha-amino acid + cholate => an N-choloyl-L-alpha-amino acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15151", "l": "H2O2 + pyridoxal 5'-phosphate => O2 + pyridoxine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45836", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0004611", "l": "phosphoenolpyruvate carboxykinase activity", "d": ["Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68603", "l": "ORC5 binds ORC2:ORC3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36957", "l": "(9Z)-pentadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + pentadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432897", "l": "ILK interacts with beta-1 integrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78357", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phospho-L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769383", "l": "CBY1 binds beta-catenin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40607", "l": "1-tetradecanoyl-sn-glycerol + H2O = glycerol + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696958", "l": "USP44 deubiquitinates CDC20 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37004", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z,16Z,19Z)-docosatrienoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10313", "l": "H(+) + NADH + O2 + terephthalate => (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675417", "l": "PEBP1 binds activated RAF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64455", "l": "L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30053", "l": "fluoride + glycolate + H(+) => fluoroacetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950456", "l": "IL12B dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806412", "l": "TP53 and AP-1 bind the MSH2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372819", "l": "PCK2 phosphorylates OA to yield PEP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24110", "l": "2-oxoglutarate + methylamine => H2O + N-methyl-2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102877", "l": "alpha-copaene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-copaene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1671687", "l": "PRLR activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76007", "l": "(3R)-hydroxybutanoate pentamer + H2O = (3R)-hydroxybutanoate tetramer + (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2465917", "l": "Photons induce isomerisation of 11c-retinyl to at-retinyl (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26056", "l": "GTP + H(+) + valienol 1-phosphate => diphosphate + GDP-valienol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66470", "l": "(17E)-cheilanthenediol => (2E,6E,10E,14E)-geranylfarnesol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40905", "l": "H(+) + hexadecanoate + sn-glycerol 3-phosphocholine => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109701", "l": "PDPK1 binds PIP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38338", "l": "(20S)-ginsenoside Rb1 + 2 H2O <=> (20S)-ginsenoside Rg3 + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707659", "l": "Hemes:LY96 activates TLR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008326", "l": "RUNX2 binds HDAC4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53913", "l": "butanoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-butanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76039", "l": "(S)-cis-N-methyltetrahydrothalifendine + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxy-8-methoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.0(4,9).0(16,20)]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749647", "l": "CES2 hydrolyzes ASA- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9709406", "l": "CO binds to Cytochrome c oxidase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450074", "l": "Interleukin-3 receptor alpha subunit binds Interleukin-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54193", "l": "L-lysyl-[protein] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63360", "l": "(S,S)-2-(C-substituted-aminomethyl)-4-acyl-2-oxazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-oxazole-[protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71659", "l": "a D-glucoside + 2 Fe(III)-[cytochrome c] = a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.1.2.11", "l": "\"glucoside 3-dehydrogenase (cytochrome c)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948757", "l": "AKT phosphorylates MKRN1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762246", "l": "ANGPTL4 binds CDH11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685838", "l": "CX3 complex binds D-loop structures (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39278", "l": "(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH <=> (15Z)-tetracosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62284", "l": "2 ATP + L-proline + L-tryptophan + NADPH = (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047676", "l": "arachidonate-CoA ligase activity", "d": ["Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67884", "l": "3'-phosphoadenylyl sulfate + dopamine = adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32061", "l": "(R)-glycerate + D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158399", "l": "kallikrein binds SERPING1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33279", "l": "L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.156", "l": "\"tryptophan N-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050152", "l": "omega-amidase activity", "d": ["Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9842833", "l": "SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52857", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] => (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033440", "l": "ACG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853762", "l": "RET dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69053", "l": "H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2 => 3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38648", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749609", "l": "BCHE hydrolyzes ASA- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426158", "l": "SREBP1A,1C binds the GPAM promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71095", "l": "2 Na(+)(out) + pregnenolone sulfate(out) = 2 Na(+)(in) + pregnenolone sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847977", "l": "FRK phosphorylates PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676206", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66054", "l": "H2O + kynurenate + L-tryptophan => indole-3-pyruvate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39079", "l": "(3S)-hydroxydodecanedioyl-CoA + NAD(+) = 3-oxododecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193694", "l": "p62 is recruited and forms a complex with TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3371518", "l": "SIRT1 binds to HSF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39746", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) <=> 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15552", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55397", "l": "(R)-carnitine + H(+) + NADH + O2 => (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53437", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140506", "l": "endoplasmic reticulum-autophagosome adaptor activity", "d": ["The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63008", "l": "(6Z)-octadecenamide + H2O = (6Z)-octadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30026", "l": "L-alanine + pyridoxal 5'-phosphate <=> pyridoxamine 5'-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708327", "l": "ANG cleaves tRNA to yield tRNA halves (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27698", "l": "GDP-beta-L-galactose + phosphate = beta-L-galactose 1-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46637", "l": "5beta-dihydrotestosterone + NADP(+) => H(+) + NADPH + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37402", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69534", "l": "4-amino-4-deoxychorismate => (2S)-2-amino-4-deoxychorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016231", "l": "beta-N-acetylglucosaminidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18321", "l": "2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60080", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707683", "l": "PGRMC2 binds Hemes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754974", "l": "ADK phosphorylates RBV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14684", "l": "2 2-aminophenol + A + O2 <=> 2-aminophenoxazin-3-one + AH2 + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13169", "l": "maleate = fumarate", "d": [], "t": []}, {"i": "EC:5.2.1.1", "l": "\"maleate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985097", "l": "OAS2 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11529", "l": "2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] => 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.188221489317044", "identifiers": [{"i": "GO:0008227", "l": "G protein-coupled amine receptor activity", "d": ["Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39678", "l": "(9Z)-hexadecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72879", "l": "(1R)-(2-amino-1-hydroxyethyl)phosphonate = NH4(+) + phosphonoacetaldehyde", "d": [], "t": []}, {"i": "EC:4.3.1.33", "l": "\"(R)-1-hydroxy-2-aminoethylphosphonate ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22009", "l": "L-homoserine + succinyl-CoA => CoA + O-succinyl-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29005", "l": "H(+)(in) + L-homoserine(out) => H(+)(out) + L-homoserine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005020", "l": "stem cell factor receptor activity", "d": ["Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42913", "l": "cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791219", "l": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-379974", "l": "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12663", "l": "CoA + O-hexadecanoyl-(R)-carnitine => (R)-carnitine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40143", "l": "(9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65827", "l": "dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166168", "l": "TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38499", "l": "a triacyl-sn-glycerol + H2O = a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23873", "l": "(R)-propane-1,2-diol + NAD(+) => (R)-lactaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1168640", "l": "Ubiquitinated IkB is degraded (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130731", "l": "Formation of COPII vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24568", "l": "a 6-phospho-beta-D-galactoside + H2O = an alcohol + D-galactose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22301", "l": "a flavonol + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174389", "l": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031787", "l": "H9 melatonin receptor binding", "d": ["Binding to a H9 melatonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236963", "l": "Maturation of phagosome into phagolysosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.57", "l": "\"heme oxygenase (mycobilin-producing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.6", "l": "\"tubulin GTPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9825772", "l": "SIRT1 deacetylates HINT1 dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13160", "l": "(R)-glycerate + CO2 + NADP(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008265", "l": "Mo-molybdopterin cofactor sulfurase activity", "d": ["Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655313", "l": "Activated FGFR4 mutants bind PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874078", "l": "PTK2 autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017096", "l": "acetylserotonin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450187", "l": "TAK1 is activated within the TAK1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40897", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-555065", "l": "Formation of clathrin coated vesicle (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35143", "l": "benzoyl-CoA + 2 H(+) + 3 malonyl-CoA = 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.220", "l": "\"2,4,6-trihydroxybenzophenone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797974", "l": "LRRTMs bind NRXNs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8955241", "l": "CAND1 binds cytosolic CRL E3 ubiquitin ligases (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001857", "l": "complement component C1q receptor activity", "d": ["Combining with the C1q complex, a component of the classical complement cascade, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655843", "l": "Expression of Fatty Acid Synthase (FASN) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14166", "l": "acetyl-CoA + L-aspartate => CoA + H(+) + N-acetyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306876", "l": "NLRP3 activation by small molecules (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805546", "l": "Keratin type I binds keratin type II (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102747", "l": "chlorophyllide-a:geranyl-geranyl diphosphate geranyl-geranyl transferase activity", "d": ["Catalysis of the reaction: H+ + chlorophyllide a(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) = geranylgeranyl-chlorophyll a + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855174", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39778", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17,18-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29532", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol => a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14354", "l": "3-dehydro-L-gulonate 6-phosphate + H(+) => CO2 + L-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627107", "l": "XIAP binds CASP7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13350", "l": "jasmonate + S-adenosyl-L-methionine => methyl (-)-jasmonate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74527", "l": "H(+) + N(6),N(6)-dimethyl-L-lysine = CO2 + N,N-dimethyl-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70334", "l": "3-hydroxyphenylacetyl-CoA + H2O <=> 3-hydroxyphenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11504", "l": "6-demethylsterigmatocystin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + sterigmatocystin", "d": [], "t": []}, {"i": "EC:2.1.1.109", "l": "\"demethylsterigmatocystin 6-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660665", "l": "Caspase-8 binds MALT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12383", "l": "L-2,4-diaminobutanoate + pyruvate <=> L-alanine + L-aspartate 4-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38029", "l": "(E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate => (E)-caffeate + hydrocaffeoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22996", "l": "H2O2 + L-ascorbate = 2 H2O + L-dehydroascorbate", "d": [], "t": []}, {"i": "EC:1.11.1.11", "l": "\"L-ascorbate peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15632", "l": "a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418662", "l": "Src activation following P2Y purinoceptor activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019788", "l": "NEDD8 transferase activity", "d": ["Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77274", "l": "2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA <=> 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51392", "l": "(9Z)-octadecenoyl-CoA + serotonin = CoA + H(+) + N-(9Z-octadecenoyl)-serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29539", "l": "a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.261", "l": "\"dolichyl-P-Man:Man8GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445067", "l": "NrCAM binds axonin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6790038", "l": "Expression of HSP90B1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74338", "l": "O-2-methylbutanoyl-(R)-carnitine(in) <=> O-2-methylbutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18492", "l": "cyanate + H(+) + hydrogencarbonate <=> carbamate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60078", "l": "4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+) => 4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169404", "l": "Transfer of ISG15 from E1 to E2 (UBCH8) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5685604", "l": "SLAMF6 binds SLAMF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73920", "l": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009936", "l": "RNASEL cleaves cellular ssRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40184", "l": "O2 + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018518", "l": "5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity", "d": ["Catalysis of the reaction: 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD+ = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56433", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944232", "l": "Association of procollagen type XII (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420202", "l": "Secretin receptor binds secretin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990458", "l": "lipooligosaccharide binding", "d": ["Binding to lipooligosaccharide. Lipooligosaccharides (LOSs) are the major glycolipids expressed on mucosal Gram-negative bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3165230", "l": "SLC52A1,2,3 transport RIB from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956659", "l": "ABL1 phosphorylates YAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-990489", "l": "Kinesin-13 is a dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37773", "l": "1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57361", "l": "H2O + NADH => (6R)-NADHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55132", "l": "ATP + D-alanine + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.54", "l": "\"D-alanine--[D-alanyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16900", "l": "a 3beta-hydroxysteroid + a triacylglycerol <=> a 3beta-hydroxysteroid ester + a diacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41865", "l": "(2E)-decenoyl-[ACP] + H(+) + NADPH => decanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-398040", "l": "Gbeta:gamma activation of PLC beta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0016163", "l": "nitrogenase activity", "d": ["Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70800", "l": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55450", "l": "a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase] => a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730870", "l": "Phosphorylation of PIP2 to PIP3 by PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35595", "l": "benzene-1,2,4-triol + O2 = 2 H(+) + maleylacetate", "d": [], "t": []}, {"i": "EC:1.13.11.37", "l": "\"hydroxyquinol 1,2-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19970", "l": "hydroxylamine + O2 => H(+) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607746", "l": "PKC-delta is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975449", "l": "GABRR pentamers:GABA transports extracellular Cl- to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-398185", "l": "LARG binds plexin B1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10002", "l": "NH4(+) + pentanoate => H2O + pentanamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52154", "l": "(Z)-indolylmethyl desulfoglucosinolate + UDP => (Z)-2-(indol-3-yl)-1-thioacetohydroximate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0047935", "l": "glucose 1-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21161", "l": "acetyl-CoA + ADP + oxaloacetate + phosphate => ATP + citrate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75727", "l": "(10E,12Z)-octadecadienoate + H2O = (10S)-hydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29834", "l": "Ni(2+)(in) <=> Ni(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9009817", "l": "Acitretin binds to RAR:RXR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63457", "l": "(2E,6E,10E)-geranylgeraniol + CTP => (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809561", "l": "I(1,3)P2 is dephosphorylated into I1P by MTMR7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2214330", "l": "Cleavage of collagen VII NC2 region by BMP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30844", "l": "H2O + N-formylmaleamate => formate + H(+) + maleamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20490", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-alanyl-tRNA(Ala) => 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031807", "l": "Protectins translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159796", "l": "Furin cleaves pro-factor IX to factor IX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47321", "l": "(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate => 3-oxo-3-phenylpropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36604", "l": "2-oxoglutarate + L-enduracididine + O2 => (3S)-3-hydroxy-L-enduracididine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29269", "l": "L-valine(out) + Na(+)(out) => L-valine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61413", "l": "ATP + N-(D-erythrulosyl)-cadaverine => ADP + H(+) + N-(3-O-phospho-D-erythrulosyl)-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140810", "l": "histone H1R54 arginine deiminase activity", "d": ["Catalysis of the reaction: H2O + histone H1 L-arginyl (position 54)= histone H1 L-citrullyl (position 54) + NH4+, resulting in histone H1 citrullination at position 54."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433451", "l": "JAK2 binds to p-KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30989", "l": "(17Z)-protosta-17(20),24-dien-3beta-ol => (S)-2,3-epoxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32276", "l": "4-(phosphooxy)-L-threonine + NAD(+) => 3-amino-2-oxopropyl phosphate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2029471", "l": "Hydrolysis of PC to PA by PLD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27607", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71838", "l": "estrone 3-sulfate(out) <=> estrone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047208", "l": "o-dihydroxycoumarin 7-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252133", "l": "ATP6AP1 binds V-ATPase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139895", "l": "tBID activates BAK protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83582", "l": "TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6804100", "l": "HMGB1 binds LPS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47591", "l": "a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GQ1c (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13515", "l": "H(+) + NADH + orotate => (S)-dihydroorotate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44775", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 <=> 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73304", "l": "H(+)(in) + oxaloacetate(out) + phosphate(in) => H(+)(out) + oxaloacetate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45225", "l": "(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA => (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035643", "l": "L-DOPA receptor activity", "d": ["Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986480", "l": "IL26:IL20RA:JAK1 binds IL10RB:TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55783", "l": "all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate <=> all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46902", "l": "a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate) (E. coli) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44652", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57446", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine => C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-199203", "l": "PANK1/3 phosphorylate PanK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209815", "l": "Tyrosine is monoiodinated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106372", "l": "primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity", "d": ["Catalysis of the reaction: H2O + primary fluorescent dioxobilin-type chlorophyll catabolite = H+ + methanol + O13(4)-desmethyl pFCC."], "t": []}, {"i": "RHEA:67176", "l": "H2O + primary fluorescent dioxobilin-type chlorophyll catabolite = H(+) + methanol + O13(4)-desmethyl pFDCC", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70971", "l": "ACO2 isomerizes citrate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047323", "l": "[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity", "d": ["Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11319", "l": "an aliphatic aldoxime <=> a nitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802942", "l": "RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-449855", "l": "IL10 dimerizes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39749", "l": "cholesterol(out) => cholesterol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46930", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41060", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA => 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70721", "l": "L-alanine(out) => L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48469", "l": "a ganglioside GM1b (d18:1(4E)) + H2O => a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61396", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683405", "l": "PPP5C dephosphorylates TP53BP1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864343", "l": "KCTD1 binds TFAP2 homo- and heterodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12918", "l": "3alpha(S)-strictosidine + H2O => D-glucose + strictosidine aglycone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0008990", "l": "rRNA (guanine-N2-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57272", "l": "a 2'-deoxyguanosine in DNA + methylglyoxal = an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3204303", "l": "MRE11 binds cytosolic DNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696547", "l": "STAMBPL1 is a deubiquitinase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172405", "l": "Collagen type XXIII ectodomain shedding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103009", "l": "3-chlorotoluene monooxygenase activity", "d": ["Catalysis of the reaction: H+ + 3-chlorotoluene + NADH + O2 = 3-chlorobenzyl alcohol + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61076", "l": "(-)-minovincinine + acetyl-CoA = (-)-echitovenine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29453", "l": "H2 + phosphate => H2O + phosphonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40317", "l": "(2E)-glutaconyl-CoA + H2O2 => glutaryl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49593", "l": "2-hydroxyisobutanoyl-CoA => (3S)-3-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64553", "l": "(3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + O2 + reduced [NADPH--hemoprotein reductase] => 3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706304", "l": "Active FLT3 binds to GRAP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9835328", "l": "NPM binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102704", "l": "GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-alpha-D-mannose(2-) + a (mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol = H+ + GDP(3-) + a (mannosyl)3-(N-acetylglucosaminyl)2-diphosphodolichol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24086", "l": "all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19499", "l": "beta-alanine + CO2 => H(+) + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649108", "l": "HTR3A pentamer binds 5HT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12536", "l": "H(+) + L-arogenate = CO2 + H2O + L-phenylalanine", "d": [], "t": []}, {"i": "EC:4.2.1.91", "l": "\"arogenate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61334", "l": "ADP + H(+) + indoxyl sulfate(out) + phosphate => ATP + H2O + indoxyl sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0008420", "l": "RNA polymerase II CTD heptapeptide repeat phosphatase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047719", "l": "indole 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: indole + O2 = 2-formamidobenzaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-445079", "l": "Phosphorylation of L1 by ERK (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56209", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] => 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157353", "l": "NEXT1 is cleaved to produce NICD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67185", "l": "(glycyl)(n)-glycyl-L-glutamyl-[protein] + ATP + glycine => (glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48906", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP => L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29645", "l": "alpha-D-glucose + D-maltohexaose => D-maltoheptaose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70677", "l": "L-arginyl-L-phenylalanine + Met-enkephalin => H2O + Met-enkephalin-Arg-Phe", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39980", "l": "(+-)-pavine + S-adenosyl-L-methionine => H(+) + N-methylpavine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73308", "l": "H(+)(in) + L-aspartate(out) + phosphate(in) => H(+)(out) + L-aspartate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10386", "l": "beta-cyclopiazonate + diphosphate => cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23676", "l": "ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": [], "t": []}, {"i": "EC:6.3.2.13", "l": "\"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55326", "l": "11-cis-retinyl hexadecanoate + CoA => 11-cis-retinol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008493", "l": "tetracycline transmembrane transporter activity", "d": ["Enables the transfer of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357432", "l": "AXL binds SRC-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0005547", "l": "phosphatidylinositol-3,4,5-trisphosphate binding", "d": ["Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32804", "l": "ATP + H2O + urea(out) => ADP + H(+) + phosphate + urea(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69139", "l": "2 H2O + 2 O2 + spermine <=> 2 H2O2 + 2 NH4(+) + spermine dialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.47", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375131", "l": "Basigin binds CD98 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39362", "l": "(13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687107", "l": "MAPK4,6 translocate to nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810472", "l": "NUDT13 hydrolyses AP6A to AP4 and ADP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654426", "l": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.2.11", "l": "\"phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63530", "l": "[thioredoxin]-disulfide + 2 H2O => [thioredoxin]-dithiol + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730894", "l": "NFKB1:RELA translocates from the cytosol to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067640", "l": "IL6 binds IL6R-2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194083", "l": "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707523", "l": "Hemes bind to BACH1:MAFK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13355", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202969", "l": "Caspase mediated cleavage of beta-catenin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4837364", "l": "Secretion of SOD3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58518", "l": "15alpha-stemmadenine intermediate I + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391939", "l": "TP receptor can bind thromboxane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47830", "l": "a ganglioside GD1b + N-acetylneuraminate => a ganglioside GT1b + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187506", "l": "Translocation of p27 to the nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24752", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite = 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.12", "l": "\"red chlorophyll catabolite reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062146", "l": "4-chloro-allylglycine synthase activity", "d": ["Catalysis of the reaction: 4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)."], "t": []}, {"i": "RHEA:59888", "l": "4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187588", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296244", "l": "SUCNR1 binds SUCCA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1297354", "l": "Acrosin Cleavage (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035983", "l": "Defective HEXB does not cleave the terminal GalNAc from keratan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428883", "l": "Recruitment of CAP to ABL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55954", "l": "a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+) => an inositol-1-phosphoceramide + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685319", "l": "CX3 complex formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796617", "l": "MIB2 binds CFLAR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8866268", "l": "ADBRK1,2 phosphorylate AVPR2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13112", "l": "2-acetamidofluorene + H2O + NAD(+) <=> H(+) + N-hydroxy-2-acetamidofluorene + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098622", "l": "selenodiglutathione-disulfide reductase (NADPH) activity", "d": ["Catalysis of the reaction: H+ + selenodiglutathione + NADPH = gluthathioselenol + glutathione + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57048", "l": "AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047293", "l": "4-hydroxybenzoate nonaprenyltransferase activity", "d": ["Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28149", "l": "geranylhydroquinone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3''-hydroxygeranylhydroquinone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623366", "l": "NR1H2,3 binds the MYLIP gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67712", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209188", "l": "TAK1-binding protein TAB2 binds to TAK1 kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866327", "l": "VLDL translocates from SER lumen to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804383", "l": "PRMT5 methylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14425", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.68", "l": "\"1-phosphatidylinositol-4-phosphate 5-kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045295", "l": "gamma-catenin binding", "d": ["Binding to catenin complex gamma subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77529", "l": "(2S)-2-hydroxyheptanenitrile => hexanal + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58924", "l": "(3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol = (-)-maackiain + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28529", "l": "(R)-carnitine + crotonobetainyl-CoA <=> (R)-carnitinyl-CoA + crotonobetaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.56", "l": "\"insulysin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55638", "l": "AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate => ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168136", "l": "Activated JNKs phosphorylate c-JUN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23755", "l": "all-trans-undecaprenol + ATP <=> ADP + all-trans-undecaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73766", "l": "2 ATP + L-alanine + L-tryptophan <=> 2 ADP + cyclo(L-tryptophyl-L-alanyl) + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66865", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + quiannulatene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433815", "l": "viral dsRNA : TRL3 recruits TICAM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31041", "l": "(2E)-dodecenoyl-CoA + FADH2 => dodecanoyl-CoA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53844", "l": "glycochenodeoxycholate + NAD(+) = 7-oxoglycolithocholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928615", "l": "EFNBs bind SFKs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392749", "l": "Transport of L1 into endosomes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51012", "l": "a monoacyl-sn-glycero-3-phosphocholine + H2O = a monoacylglycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47038", "l": "pseudouridine in 5S rRNA => uridine in 5S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15230", "l": "alpha-D-mannose 1-phosphate + GTP + H(+) => diphosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005335", "l": "serotonin:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19808", "l": "a purine D-ribonucleoside + phosphate <=> a purine nucleobase + alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71146", "l": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21014", "l": "4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749792", "l": "CES1,CES2 hydrolyze ASA- to ST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3095889", "l": "MMACHC dealkylates RCbl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797961", "l": "CHDH oxidises Cho to BETALD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56281", "l": "3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] => AMP + L-prolyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45460", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61393", "l": "ATP + N(6)-(D-psicosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11958", "l": "cholesterol + D-glucose => cholesteryl 3-beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76347", "l": "(2R,3S)-3-isopropylmalate(in) + sulfate(out) = (2R,3S)-3-isopropylmalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354124", "l": "Phosphorylation of pPTK2 by SRC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13947", "l": "(R)-mandelate => (S)-mandelate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35665", "l": "a 1-acyl-sn-glycerol + a fatty acid + H(+) => a 1,2-diacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034016", "l": "polyenoic fatty acid isomerase activity", "d": ["Catalysis of the reaction: all-cis-icosa-5,8,11,14,17-pentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21848", "l": "(E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide", "d": [], "t": []}, {"i": "EC:5.2.1.6", "l": "\"furylfuramide isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44744", "l": "4 H(+) + 4 malonyl-CoA = (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O", "d": [], "t": []}, {"i": "EC:2.3.1.246", "l": "\"3,5-dihydroxyphenylacetyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49328", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene = 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186819", "l": "SH2 domain of Src binds to the active receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362416", "l": "Frataxin binds iron (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59693", "l": "D-cellotriono-1,5-lactone + H2O => D-cellotrionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45645", "l": "H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine => H(+) + N-hexadecanoylsphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60055", "l": "a 3beta-hydroxy-4,4-dimethylsteroid + H(+) + NADH + O2 <=> a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24796", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21165", "l": "a carboxylic ester + H2O => a carboxylate + an alcohol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686073", "l": "GRB2-1:SOS1 binds p-3Y-SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050204", "l": "oxalomalate lyase activity", "d": ["Catalysis of the reaction: 3-oxalomalate = glyoxylate + oxaloacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71526", "l": "adenine(out) <=> adenine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047757", "l": "chondroitin-glucuronate 5-epimerase activity", "d": ["Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610720", "l": "PKA phosphorylates GLI3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63504", "l": "daunorubicin + H(+) + NADPH = 13-dihydrodaunorubicin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71323", "l": "chloride(out) + L-asparagine(out) + 2 Na(+)(out) = chloride(in) + L-asparagine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052815", "l": "medium-chain fatty acyl-CoA hydrolase activity", "d": ["Catalysis of the reaction: a medium-chain fatty acyl-CoA + H2O = a medium-chain fatty acid + CoA + H+. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399913", "l": "atRAL binds to RBP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214853", "l": "WEK and MYD88:TUB bind to the TL receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22968", "l": "butanal + CoA + NAD(+) = butanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173705", "l": "C5b binds C6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55588", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592316", "l": "Initial activation of proMMP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949687", "l": "LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2317314", "l": "AKT binds PDPK1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47943", "l": "a ganglioside GM2 (d18:1(4E)) + H2O <=> a ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51394", "l": "CoA + H(+) + N-(9Z-octadecenoyl)-serotonin => (9Z)-octadecenoyl-CoA + serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679775", "l": "COMT binds COMT Inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77632", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol => 1-tetradecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36231", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952371", "l": "MDM2 binds RUNX3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.43", "l": "\"phosphogluconate 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188002", "l": "Rab5-mediated recruitment of class III PI3K to TLR9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68523", "l": "(2E,6E)-farnesyl diphosphate <=> beta-acoradiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0036041", "l": "long-chain fatty acid binding", "d": ["Binding to a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018698", "l": "vinyl chloride reductive dehalogenase activity", "d": ["Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701064", "l": "TRPV1 binds TRPV1 agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097365", "l": "stretch-activated, monoatomic cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential in a cardiac muscle cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27541", "l": "ethanol + N,N-dimethyl-4-nitrosoaniline <=> 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33707", "l": "ATP + L-threonine = ADP + H(+) + O-phospho-L-threonine", "d": [], "t": []}, {"i": "EC:2.7.1.177", "l": "\"L-threonine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467716", "l": "AGRN binds Alpha-dystroglycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654515", "l": "KAL1 binds HS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187035", "l": "Pro-beta-NGF and mature beta-NGF are secreted (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13780", "l": "ATP + D-ribose 5-phosphate + NH4(+) <=> 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381644", "l": "ER calcium channels open in response to activated PKA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61656", "l": "(2E,6E)-farnesol + ATP = (2E,6E)-farnesyl phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033862", "l": "UMP kinase activity", "d": ["Catalysis of the reaction: ATP + UMP = ADP + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770119", "l": "Formation of the Spliceosomal E complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445704", "l": "Calcium Binds Caldesmon (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10385", "l": "cyclo-acetoacetyl-L-tryptophan + dimethylallyl diphosphate => beta-cyclopiazonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44217", "l": "12-hydroxyoctadecanoate + ATP + CoA => 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78871", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NAD(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45960", "l": "24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77722", "l": "a neolactoside IV(3)-alpha-NeuGc-nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine <=> a neolactoside IV(4)-beta-GalNAc-IV(3)-alpha-NeuGc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1013020", "l": "Activation of GIRK/Kir3 Channels (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796082", "l": "AcK-NFE2L2 binds the EGF gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9840488", "l": "PSAP(195-273) forms a dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008405", "l": "arachidonic acid 11,12-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid."], "t": []}, {"i": "RHEA:51480", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180000", "l": "histone methyltransferase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a histone methyltransferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36914", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13886", "l": "H2O + stipitatonate => CO2 + stipitatate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10985", "l": "(S)-lactate + oxaloacetate => (S)-malate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61784", "l": "L-allulose = keto-L-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380782", "l": "STAT binds to the active receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050617", "l": "15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28738", "l": "H(+)(in) + spermidine(out) <=> H(+)(out) + spermidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666008", "l": "SCAI binds SRF:MKL1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25108", "l": "ATP + pyridoxine = ADP + H(+) + pyridoxine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36819", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610036", "l": "Defective GALE does not epimerise UDP-Gal to UDP-Glc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41952", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.118", "l": "\"[amino group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54821", "l": "a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine => a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103037", "l": "L-glyceraldehyde 3-phosphate reductase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + NADP = H+ + L-glyceraldehyde 3-phosphate + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39889", "l": "H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin => 2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9861631", "l": "ME1 tetramerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177284", "l": "PKA phosphorylates PDE4B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684241", "l": "Recruitment of Spike trimer to assembling virion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9859172", "l": "DLD dimer dehydrogenates dihydrolipoyl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050227", "l": "pteridine oxidase activity", "d": ["Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66818", "l": "2 Na(+)(out) + tetrahydroxoborate(out) => 2 Na(+)(in) + tetrahydroxoborate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37669", "l": "3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446216", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43514", "l": "2-carboxy-5-formylfuran + H(+) + H2O2 => 2-(dihydroxymethyl)-5-formylfuran + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36591", "l": "(S)-2-chloropropanoate + NADP(+) = 2-chloroacrylate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.103", "l": "\"2-haloacrylate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0032549", "l": "ribonucleoside binding", "d": ["Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63421", "l": "2-hydroxyethylphosphonate + CTP => cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54013", "l": "(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O => (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57101", "l": "S-methyl-5-thio-D-ribulose 1-phosphate => S-methyl-1-thio-D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.73", "l": "\"inosine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20915", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + taxa-4,11-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61274", "l": "2-oxopentanoate + H2O2 + NH4(+) => H2O + L-2-aminopentanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140787", "l": "phosphate ion uniporter activity", "d": ["Catalysis of the active transport of a phosphate ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33169", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + sn-glycero-3-phospho-1D-myo-inositol => 2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106340", "l": "tRNA (guanine(34)-2'-O)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 34 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 34 in tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.14", "l": "\"aromatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18353", "l": "ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.13", "l": "\"Na(+)/K(+)-exchanging ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66115", "l": "2-oxobutanoate + L-tyrosine <=> (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749505", "l": "LRRC14 binds IKBKB and CHUK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30731", "l": "butanoyl-CoA + FAD + H(+) = (2E)-butenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31914", "l": "beta-D-fructose 1,6-bisphosphate + methylglyoxal <=> 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41105", "l": "(9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+) => 1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76570", "l": "3'-dehydrocarminate + H(+) <=> 1,5-anhydro-D-erythro-hex-1-en-3-ulose + kermesate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27857", "l": "(2E)-geranyl diphosphate + 4-hydroxybenzoate <=> 3-geranyl-4-hydroxybenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9834945", "l": "PINK1 phosphorylates Ub on MOM proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008897", "l": "holo-[acyl-carrier-protein] synthase activity", "d": ["Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33798", "l": "H2O + sucrose <=> alpha-D-glucose + beta-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24108", "l": "H2O + N-methyl-2-oxoglutaramate = 2-oxoglutarate + methylamine", "d": [], "t": []}, {"i": "EC:3.5.1.36", "l": "\"N-methyl-2-oxoglutaramate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52293", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49968", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201443", "l": "Type II receptor phosphorylates type I receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030544", "l": "Hsp70 protein binding", "d": ["Binding to a Hsp70 protein, heat shock proteins around 70kDa in size."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109701", "l": "PDPK1 binds PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-111925", "l": "cAMP induces dissociation of inactive PKA tetramers (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669240", "l": "FLNA binds PAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72300", "l": "3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) => 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15849", "l": "2 Fe(III)-[cytochrome c] + L-ascorbate = 2 Fe(II)-[cytochrome c] + 2 H(+) + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21982", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n) => 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9860278", "l": "p-S446-IRF5 dimer translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74405", "l": "2 (S)-lactate(out) + prostaglandin D2(in) => 2 (S)-lactate(in) + prostaglandin D2(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198714", "l": "ERK5 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75794", "l": "(S)-lactate(out) + Na(+)(out) <=> (S)-lactate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632939", "l": "TP53 binds the PTEN promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48857", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 => (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59779", "l": "D-arabinitol + O2 <=> D-arabinose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3296233", "l": "T2Rs bind bitter-tasting compounds (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19646", "l": "a D-threo-aldose + NAD(+) => a D-threo-aldono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374919", "l": "Noradrenaline clearance from the synaptic cleft (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73305", "l": "H(+)(out) + oxaloacetate(in) + phosphate(out) => H(+)(in) + oxaloacetate(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018535", "l": "nicotine dehydrogenase activity", "d": ["Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37654", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12155", "l": "(3R,4S,5S,6R)-pentachlorocyclohexene <=> (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047108", "l": "(R)-3-hydroxyacid-ester dehydrogenase activity", "d": ["Catalysis of the reaction: ethyl (R)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + H+ + NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40014", "l": "(+)-copalyl diphosphate + H2O <=> diphosphate + manool", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26533", "l": "4-hydroxybutanoyl-CoA <=> (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097627", "l": "high-affinity L-ornithine transmembrane transporter activity", "d": ["Enables the transfer of L-ornithine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42755", "l": "pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19516", "l": "carbamoyl phosphate + L-ornithine <=> H(+) + L-citrulline + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26138", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.13.2.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45442", "l": "H(+) + N-eicosanoyl ethanolamine + sn-glycerol 3-phosphate => H2O + N-eicosanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2024108", "l": "Some HSPGs are secreted to the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551555", "l": "RYK binds WNT5A and VANGL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70120", "l": "6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8942607", "l": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218836", "l": "PTK2beta binds alphaVbeta3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24575", "l": "[(1->4)-alpha-D-glucosyl](n) + sucrose <=> [(1->4)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58158", "l": "ADP + H(+) + 4 Na(+)(out) + phosphate => ATP + H2O + 4 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36084", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + H2O => 1-O-alkyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332363", "l": "Autophosphorylation and activation of CAMK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373075", "l": "Metabotropic glutamate receptors bind glutamate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164515", "l": "Fusogenic activation of gp41 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66808", "l": "5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH = 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43395", "l": "1D-myo-inositol 1,3,4-trisphosphate + H2O <=> 1D-myo-inositol 1,3-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446701", "l": "IRAK4-activated IRAK1 autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0062037", "l": "D-loop DNA binding", "d": ["Binding to a DNA D-loop. A D-loop is a three-stranded DNA structure formed by the invasion of a single DNA strand that base pairs with one strand of duplex DNA, while the rest of the double-stranded DNA does not unwind."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63339", "l": "alpha-D-xylose <=> beta-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5651773", "l": "LIG1 binds POLB at long-patch BER site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76187", "l": "an L-amino acid tripeptide(out) + 2 H(+)(out) = an L-amino acid tripeptide(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73758", "l": "Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1564169", "l": "Collagen type VIII degradation by MMP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358460", "l": "HPE SHH variants don't undergo autoproteolytic cleavage (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5218854", "l": "p-Y420-FYN is phosphorylated on S21 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052613", "l": "canthaxanthin 3-hydroxylase activity", "d": ["Catalysis of the reaction: canthaxanthin + a reduced electron acceptor + oxygen = adonirubin + an oxidized electron acceptor + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114264", "l": "Translocation of activated BAX to the mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49917", "l": "(R)-carnitine(out) + O-hexadecanoyl-(R)-carnitine(in) => (R)-carnitine(in) + O-hexadecanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65143", "l": "AH2 + O2 + protoaustinoid A <=> A + berkeleyone A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.17", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801762", "l": "REG3A oligomerize to form a pore complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5653957", "l": "Rag dimer formation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9669874", "l": "Sorafenib-resistant KIT mutants do not bind sorafenib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32293", "l": "3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine => phosphoethanolamine + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14198", "l": "ATP + L-aspartate + NH4(+) => ADP + H(+) + L-asparagine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62894", "l": "6 CO2 + 7 CoA + 2 H2O + nor-toralactone => acetyl-CoA + 6 H(+) + 6 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.352372097681226", "identifiers": [{"i": "GO:0016229", "l": "steroid dehydrogenase activity", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5669158", "l": "NF2 binds PAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69456", "l": "3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32253", "l": "(6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74926", "l": "a (3R)-3-[(carboxymethyl)amino]fatty acid + H(+) + holo-[ACP] <=> a (2E)-enoyl-[ACP] + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56770", "l": "2 A + all-trans-adonixanthin + 3 H2O => 2 AH2 + all-trans-zeaxanthin + 2 O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48247", "l": "a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GM1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57510", "l": "(2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate => H2O + NADP(+) + staphylopine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70943", "l": "L-isoleucine(in) = L-isoleucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64487", "l": "acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA <=> 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75849", "l": "SLC25A1 exchanges CIT and MAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14068", "l": "scyllo-inosose <=> 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49684", "l": "H(+) + NADH + O2 + resorcinol = benzene-1,2,4-triol + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.220", "l": "\"resorcinol 4-hydroxylase (NADH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76514", "l": "5-deoxystrigol + H2O <=> 5-deoxystrigol ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026408", "l": "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3797202", "l": "AP-1 stimulates transcription of IGFBP7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51928", "l": "H2O + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) = (S)-2,3-diaminopropanoate + 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.5.1.51", "l": "\"N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36828", "l": "dioscin + 3 H2O => D-glucose + diosgenin + 2 L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9825751", "l": "HINT1 binds MITF-M (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611852", "l": "ADRB3 bind ADR,NAd (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62881", "l": "9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + AH2 => (3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6802973", "l": "PLK3 phosphorylates CDC25C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32455", "l": "(-)-vetispiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + solavetivone", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78994", "l": "a 4-carboxy-3-alkylbut-(2E)-enoyl-[ACP] + H(+) <=> a 3-alkylbut-(2E)-enoyl-[ACP] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669023", "l": "TWEAK binds FN14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50563", "l": "acetyl-CoA + N-terminal L-methionyl-L-tryptophyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45076", "l": "(9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase] = (9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65693", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine => a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9853368", "l": "FIRRM binds FIGNL1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54809", "l": "H(+) + L-isoleucine-(+)-7-isojasmonate + NADPH + O2 => H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340251", "l": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75820", "l": "(5Z,8Z)-octadecadienoate + O2 => (5S)-hydroperoxy-(6E,8Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64052", "l": "(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine = CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102531", "l": "ecdysteroid-phosphate phosphatase activity", "d": ["Catalysis of the reaction: H2O + an ecdysteroid 22-phosphate = hydrogenphosphate + an ecdysteroid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5603114", "l": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102808", "l": "pelargonidin 3-O-glucoside 2''-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + pelargonidin 3-O-beta-D-glucoside = H+ + pelargonidin 3-O-sophoroside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33272", "l": "a triacyl-sn-glycerol + H2O => a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64543", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23250", "l": "1D-4-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine => myo-inositol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417825", "l": "P2Y11 receptor can bind to ATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54257", "l": "2-oxoglutarate + L-histidyl-[protein] + O2 => (3S)-3-hydroxy-L-histidyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53319", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate <=> alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62755", "l": "H2O + pravastatin lactone <=> (S)-2-methylbutanoate + H(+) + pravastatin diol lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17156", "l": "CDP-D-glucose <=> CDP-4-dehydro-6-deoxy-D-glucose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25884", "l": "carbamoyl phosphate + N(2)-succinyl-L-ornithine = H(+) + N(2)-succinyl-L-citrulline + phosphate", "d": [], "t": []}, {"i": "EC:2.1.3.11", "l": "\"N-succinylornithine carbamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0061860", "l": "DNA clamp unloader activity", "d": ["Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27511", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine => dehydro coenzyme F420-0 + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46654", "l": "5beta-dihydroepitestosterone + NADP(+) => epitestosterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853793", "l": "p-5Y-RET complexes bind GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58512", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36712", "l": "ATP + H(+) + H2O + O-ureido-D-serine => ADP + CO2 + D-cycloserine + NH4(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72259", "l": "L-dopa + S-adenosyl-L-methionine = 3-O-methyl-L-dopa + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759158", "l": "SQSTM1 oligomerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75897", "l": "CoA + thiomarinol C => holothin + marinoloyl-CoA C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684836", "l": "CLEC1B dimer binds PDPN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23855", "l": "catechol + O2 <=> cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68217", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + 1,2-dihexanoylglycerol => 1,2-dihexanoyl-3-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28566", "l": "3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP = 6 AMP + enterobactin + 7 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850854", "l": "NTPDase1 hydrolyzes nucleoside diphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036219", "l": "GTP diphosphatase activity", "d": ["Catalysis of the reaction: GTP + H2O = GMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29018", "l": "phosphate(out) + sn-glycerol 3-phosphate(in) <=> phosphate(in) + sn-glycerol 3-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67425", "l": "a glycerophospholipid + H2O => a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66909", "l": "acetyl-CoA + 20 H(+) + 9 malonyl-CoA + 13 NADPH + S-adenosyl-L-methionine => 9 CO2 + 10 CoA + 7 H2O + 13 NADP(+) + S-adenosyl-L-homocysteine + soppiline A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989773", "l": "Expression of CPT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047158", "l": "sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity", "d": ["Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucose = 1,2-di-O-sinapoyl-beta-D-glucose + D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009024", "l": "tagatose-6-phosphate kinase activity", "d": ["Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682011", "l": "LC3 binds ATG7 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177922", "l": "EGFR dimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23069", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + 6 NADPH + propanoyl-CoA => 6-deoxyerythronolide B + 6 CO2 + 7 CoA + H2O + 6 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34039", "l": "2-oxoglutarate + neamine = 6'-oxoparomamine + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.93", "l": "\"neamine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12030", "l": "H(+) + N-carbamoyl-L-aspartate => H2O + L-5-carboxymethylhydantoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30793", "l": "dGDP + H(+) + phosphoenolpyruvate => dGTP + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047024", "l": "5alpha-androstane-3beta,17beta-diol dehydrogenase activity", "d": ["Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696358", "l": "TREM,CD300 binds lipids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789218", "l": "Hypochlorous acid (HOCl) reacts with unsaturated lipid to form lipid chlorohydrins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4755494", "l": "PIAS1,2-1 SUMOylate NR5A2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30540", "l": "(R)-carnitinyl-CoA => (S)-carnitinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62329", "l": "(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) => (+)-malbrancheamide + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187608", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682826", "l": "LGI1 binds ADAM11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35119", "l": "(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O = bisdemethoxycurcumin + CO2 + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209218", "l": "Phosphorylated DL/DIF dimer activates transcription (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13107", "l": "glycerol + phosphate => glycerol 2-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161612", "l": "PGH2 is reduced to PGF2a by FAM213B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11693", "l": "NAD(+) + NADPH => NADH + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610732", "l": "GSK3 phosphorylates p-GLI3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024872", "l": "ALOX15 oxidises 17(S)-Hp-DHA to PDX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77881", "l": "(1-deoxy-D-fructos-1-yl)amine + an aldehyde + H2O2 => an N-(1-deoxy-beta-D-fructopyranos-1-yl)amine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68405", "l": "(2R,3S)-iso(homo)2citrate + NAD(+) => 2-oxoheptanedioate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5651828", "l": "PARG dePARylates PARP1,PARP2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1358798", "l": "RNF41 binds neuregulin-activated ERBB3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71717", "l": "H(+)(in) + L-leucyl-L-leucine(in) => H(+)(out) + L-leucyl-L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24398", "l": "1,3,8-trihydroxynaphthalene + H2O => scytalone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0047453", "l": "ATP-dependent NAD(P)H-hydrate dehydratase activity", "d": ["Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H+ + NADH + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18764", "l": "a 1,2-diacyl-sn-glycerol + H2O <=> a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10628", "l": "phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)", "d": [], "t": []}, {"i": "EC:2.7.7.56", "l": "\"tRNA nucleotidyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39016", "l": "22-oxodocosanoate + H2O + NAD(+) => docosanedioate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63842", "l": "[thioredoxin]-disulfide + H2O + tert-butanol => [thioredoxin]-dithiol + tert-butyl hydroperoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9824994", "l": "RPS6KA1-dependent phosphorylation of MITF-M (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32386", "l": "(1S,2S,4R)-limonene-1,2-diol + NAD(+) <=> (1S,4R)-1-hydroxylimonen-2-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71920", "l": "3 Na(+)(out) + succinate(out) => 3 Na(+)(in) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176517", "l": "SULTs transfer (SO4)2- group to PREG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879910", "l": "JAK2 is phosphorylated, activated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11639", "l": "NADP(+) + prostaglandin E1 <=> 15-oxoprostaglandin E1 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25996", "l": "H2O + N(1)-acetylspermine + O2 = H2O2 + N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56256", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2089971", "l": "Secretion of collagens (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5658435", "l": "RAS GAPs bind RAS:GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689111", "l": "PARK2 autoubiquitinates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110307", "l": "REV1 binds AP-dsDNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18544", "l": "10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine <=> dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27577", "l": "(3R)-piperidine-3-carboxamide + H2O <=> (3R)-piperidine-3-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9679044", "l": "FKBP1A binds sirolimus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381799", "l": "Synthesis of Preproglucagon in intestinal L cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3777129", "l": "HDAC3 containing complexes deacetylate histone (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33679", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 = 2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51825", "l": "ATP(in) + CoA(in) + H(+)(out) + octanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + octanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654149", "l": "Activated FGFR1 phosphorylates PLCG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26236", "l": "(2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981892", "l": "Active G alpha (z) binds RGS proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39714", "l": "O2 + 2 reduced coenzyme F420-(gamma-L-Glu)(n) <=> 2 H(+) + 2 H2O + 2 oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602484", "l": "Activation of proMMP11 by FURIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70273", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate => 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22803", "l": "cycloeucalenol <=> obtusifoliol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047495", "l": "membrane-oligosaccharide glycerophosphotransferase activity", "d": ["Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849857", "l": "KLK5 cleaves and activates CELA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.12", "l": "\"dihydrobenzophenanthridine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53295", "l": "H2O + L-5-[2-(methysulfanyl)ethyl]hydantoin <=> H(+) + N-carbamoyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203611", "l": "N-myristoylation of eNOS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30210", "l": "H2O + methylamine + 2 oxidized [amicyanin] <=> formaldehyde + 2 H(+) + NH4(+) + 2 reduced [amicyanin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42684", "l": "gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide", "d": [], "t": []}, {"i": "EC:3.5.1.118", "l": "\"gamma-glutamyl hercynylcysteine S-oxide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70869", "l": "L-alanine(in) + L-glutamine(out) + Na(+)(in) => L-alanine(out) + L-glutamine(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43168", "l": "adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.33", "l": "\"tRNA(adenine(34)) deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17575", "l": "H(+) + macrocin + S-adenosyl-L-homocysteine => demethylmacrocin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871266", "l": "YAP1 binds TEAD3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "64.053760442736788", "identifiers": [{"i": "GO:0016779", "l": "nucleotidyltransferase activity", "d": ["Catalysis of the transfer of a nucleotidyl group to a reactant."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54770", "l": "[LarE protein]-dehydroalanine + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22689", "l": "D-alanine + H2O + O2 => H2O2 + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73082", "l": "S-adenosyl-L-methionine + scutellarein <=> S-adenosyl-L-homocysteine + scutellarein 7-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694436", "l": "nsp15 forms a hexamer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42672", "l": "gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-glutamyl-hercynylcysteine S-oxide + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.50", "l": "\"gamma-glutamyl hercynylcysteine S-oxide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45672", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938773", "l": "RNF144A polyubiquitinates PRKDC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622980", "l": "FOXO1 binds NPY gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50736", "l": "a quinone + 2 H(+) + hydrogen sulfide + sulfite = a quinol + thiosulfate", "d": [], "t": []}, {"i": "EC:1.8.5.5", "l": "\"thiosulfate reductase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0004124", "l": "cysteine synthase activity", "d": ["Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74174", "l": "an N-methyl carbamate ester + H(+) + H2O <=> an alcohol + CO2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21965", "l": "an acylcholine + H2O => a carboxylate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878914", "l": "B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395872", "l": "NUDT1 hydrolyses 2-oxo-ATP to 2-oxo-AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004754", "l": "saccharopine dehydrogenase (NAD+, L-lysine-forming) activity", "d": ["Catalysis of the reaction: L-saccharopine + H2O + NAD+ = 2-oxoglutarate + L-lysine + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687673", "l": "MRN recruits LIG3:XRCC1 to MMEJ sites (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42641", "l": "a 2-demethylmenaquinol + S-adenosyl-L-methionine => a menaquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047787", "l": "Delta4-3-oxosteroid 5beta-reductase activity", "d": ["Catalysis of the reaction: a 3-oxo-5beta-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + H+ + NADPH. The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent. The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3- one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755368", "l": "TLR2:TLR1 binds SARS-CoV-2 E pentamer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52854", "l": "6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin] => a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40777", "l": "D-alpha-phenylglycine + NH4(+) => 2-amino-2-phenylacetonitrile + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0019870", "l": "potassium channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a potassium channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937792", "l": "RUNX3 binds SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10531", "l": "dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9725206", "l": "IgE binds FCERI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62704", "l": "glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012349", "l": "ME3 tetramer decarboxylates MAL to PYR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44018", "l": "2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH => 2,6,10,14-tetramethylpentadecanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59302", "l": "adenosine 3',5'-bisphosphate + firefly D-sulfoluciferin + H(+) => 3'-phosphoadenylyl sulfate + firefly D-luciferin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61906", "l": "H2O + NADP(+) + stemphyloxin II => betaenone A + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076392", "l": "EXT1:EXT2 transfers GlcA to heparan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52581", "l": "ATP + H2O + Pb(2+)(in) => ADP + H(+) + Pb(2+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34293", "l": "2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP => 2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033407", "l": "UCA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UCA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046589", "l": "ribonuclease T1 activity", "d": ["Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50453", "l": "prostaglandin H3 => prostaglandin E3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9842115", "l": "PSAP(195-273) dimer binds PE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35802", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O <=> 7,8-dihydroneopterin 3'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247645", "l": "RHAG transports CO2 from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373711", "l": "DCC interaction with Netrin-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19968", "l": "S,S-dimethyl-beta-propiothetin <=> acrylate + dimethyl sulfide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694409", "l": "Nucleotide exchange on RAB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9854463", "l": "SIRT3 deacetylates AcK-IDH2 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850997", "l": "TRIM27 binds PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63057", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine => 5-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204824", "l": "Interaction of Tie2 and Ang4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70996", "l": "L-cystine(out) + L-glutamate(in) => L-cystine(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757256", "l": "MCM3 binds MCM5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19144", "l": "all-trans-retinol <=> 11-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084984", "l": "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839379", "l": "TGFBR3 binding to FGF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.12", "l": "\"2,4-diaminopentanoate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629679", "l": "PDE3A inhibitors bind PDE3A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43759", "l": "acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75307", "l": "D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25926", "l": "8-hydroxyquinolin-2(1H)-one + AH2 => A + H2O + quinolin-8-ol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703441", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36021", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34786", "l": "a 3alpha-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9748991", "l": "XDH oxidises 6MP to 6TU (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432946", "l": "PARVB/Affixin interacts with alpha PIX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65961", "l": "ATP + H2O + leukotriene C4(out) => ADP + H(+) + leukotriene C4(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2213205", "l": "Type XII and XIV collagens associate with type I and type II fibrils. (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.4.7", "l": "\"hydroperoxy icosatetraenoate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25818", "l": "3-aminopropanal + H2O2 + norspermidine => H2O + norspermine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24225", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) => 4-methylcatechol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54754", "l": "dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034944", "l": "3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA + NAD+ = 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + NADH+ + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679775", "l": "COMT binds COMT Inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-996727", "l": "REST recruits the BHC complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601922", "l": "Complexed PIWIL2 binds cleaved transposon RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69129", "l": "glyoxylate + L-leucine => 4-methyl-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56174", "l": "8-demethyl-8-formylriboflavin 5'-phosphate + H2O => FMN + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23235", "l": "4 Fe(III)-[cytochrome c] + hydrazine <=> 4 Fe(II)-[cytochrome c] + 4 H(+) + N2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980067", "l": "NOTCH1 stimulates MYC transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3247839", "l": "Retromer associates with WLS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130619", "l": "TGN-lysosomal vesicle coat assembly (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32746", "l": "L-homocysteine + O-acetyl-L-serine <=> acetate + H(+) + L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20612", "l": "2-dehydro-3-deoxy-D-arabinonate <=> glycolaldehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64289", "l": "2 nataloe emodin + O2 + reduced [NADPH--hemoprotein reductase] => cladofulvin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3209159", "l": "Phosphorylated ERF translocates to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56469", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 => (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72097", "l": "(S)-carnitine(in) + Na(+)(in) => (S)-carnitine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0140699", "l": "cyclic GMP-AMP synthase activity", "d": ["Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102262", "l": "tRNA-dihydrouridine16 synthase activity", "d": ["Catalysis of the reaction: a 5,6-dihydrouracil16 in tRNA + NAD(P) = H+ + a uracil16 in tRNA + NAD(P)H."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47022", "l": "[DsrC protein]-disulfide + 3 AH2 + 2 H(+) + sulfite => [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29786", "l": "ATP + H2O + L-cysteine(in) <=> ADP + H(+) + L-cysteine(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607746", "l": "PKC-delta is activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33271", "l": "a triacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-351948", "l": "Mitochondrial recruitment of Drp1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4341072", "l": "SUMOylation of RARA with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015529", "l": "raffinose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3134804", "l": "STING ubiquitination by TRIM32 or TRIM56 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66596", "l": "O2 + 2 tyramine = 2 dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13119", "l": "3-(pyrazol-1-yl)-L-alanine + acetate + H(+) => O-acetyl-L-serine + pyrazole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036068", "l": "Defective GUSB does not hydrolyse GlcA-β1,3-GlcNAc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1306957", "l": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43152", "l": "adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.220", "l": "\"tRNA (adenine(58)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683588", "l": "ATG10 transfers ATG12 from ATG10 to ATG5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.34", "l": "\"trans-feruloyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71965", "l": "(R)-2-hydroxyglutarate(in) + 3 Na(+)(in) => (R)-2-hydroxyglutarate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27969", "l": "7,8-dihydroneopterin 3'-triphosphate + H2O <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61368", "l": "4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41330", "l": "(12S)-hydroperoxy-(8Z,10E,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062205", "l": "miltiradiene synthase activity", "d": ["Catalysis of the reaction: (+)-copalyl diphosphate = diphosphate + miltiradiene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25209", "l": "H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine = acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75008", "l": "H(+)(out) + VO(2+)(out) => H(+)(in) + VO(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693001", "l": "NAT8,8B acetylate BACE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507870", "l": "Aquaporins passively transport water out of cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17791", "l": "(S)-reticuline + H(+) + S-adenosyl-L-homocysteine => (S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9795153", "l": "Basolateral excretion of oxo-Cipro (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549322", "l": "OCT1 transports organic cations out of hepatic cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43201", "l": "cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48169", "l": "H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine => N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42306", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784628", "l": "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43394", "l": "1D-myo-inositol 1,3-bisphosphate + phosphate => 1D-myo-inositol 1,3,4-trisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63317", "l": "(9Z,12Z)-octadecadienoate + O2 => 9-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23276", "l": "2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde", "d": [], "t": []}, {"i": "EC:4.1.2.12", "l": "\"2-dehydropantoate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73291", "l": "H(+)(out) + L-valine(in) = H(+)(in) + L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34213", "l": "ecgonone methyl ester + H(+) + NADPH => ecgonine methyl ester + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31148", "l": "3,4-dihydroxyphenylethyleneglycol + NAD(+) => 3,4-dihydroxymandelaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31208", "l": "FAD + H(+) + hexanoyl-CoA => (2E)-hexenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103001", "l": "dimethylsulfoxide oxygenase activity", "d": ["Catalysis of the reactions: dimethyl sulfoxide + H+ + NADH + O2 = dimethyl sulfone + H2O + NAD+ and dimethyl sulfide + H+ + NADH + O2 = dimethyl sulfoxide + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55592", "l": "2 (3R)-hydroxydecanoyl-[ACP] + H2O = (3R)-3-[(3R)-3-hydroxydecanoyloxy]decanoate + H(+) + 2 holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705681", "l": "MPP5 binds SARS-CoV-2 E pentamer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674022", "l": "BRAP autoubiquitinates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196773", "l": "COASY phosphorylates DP-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8985343", "l": "RUNX2 binds SOX9 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66214", "l": "asc-omegaDeltaC5-CoA + H2O2 => asc-omegaC5-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62728", "l": "(+)-malbrancheamide B + bromide + FAD + 2 H(+) = (+)-malbrancheamide D + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4655431", "l": "SUMOyation of DNMT1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45394", "l": "(9Z)-octadecenoate + H(+) + N-eicosanoyl-sn-glycero-3-phosphoethanolamine => H2O + N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13128", "l": "CoA + glutathione disulfide <=> CoA-glutathione + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186765", "l": "PLC-gamma binds to the active receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22216", "l": "(E)-caffeate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.22", "l": "\"caffeate 3,4-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806732", "l": "GNLY binds the bacterial cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3215310", "l": "USP7 deubiquitinates TP53 and counteracts MDM2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27329", "l": "H(+) + NADH + O2 + urate = 5-hydroxyisourate + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.113", "l": "\"FAD-dependent urate hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58020", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = eupatolide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10003", "l": "H2O + pentanamide <=> NH4(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047892", "l": "flavone apiosyltransferase activity", "d": ["Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13561", "l": "H2O + meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.1.16", "l": "\"diaminopimelate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047799", "l": "cyclopentanone monooxygenase activity", "d": ["Catalysis of the reaction: cyclopentanone + H+ + NADPH + O2 = 5-valerolactone + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61484", "l": "a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69779", "l": "2-oxindole-3-acetate + succinyl-CoA = (2-oxoindol-3-yl)acetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49164", "l": "a bacteriochlorophyllide c + H2O + S-adenosyl-L-methionine = 5'-deoxyadenosine + a 7(1)-hydroxybacteriochlorophyllide c + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30185", "l": "H(+) + keto-D-tagaturonate + NADH => L-galactonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863494", "l": "ASICs bind STOML3, (STOM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007882", "l": "IL1F10 is cleaved (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68699", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19715", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65030", "l": "(+)-6-hydroxypinoresinol + 2 H(+) + 2 reduced [azurin] => (+)-pinoresinol + H2O + 2 oxidized [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23946", "l": "4-O-(beta-D-glucosyl)-(E)-coniferol + H(+) + UDP => (E)-coniferol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37776", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octanoyl-CoA => 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10376", "l": "ATP + Cu(2+)(in) + H2O = ADP + Cu(2+)(out) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.9", "l": "\"P-type Cu(2+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11634", "l": "A + H(+) + hydrogenselenide + L-alanine => AH2 + L-selenocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026917", "l": "Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72529", "l": "1,6-dimethoxyphenazine + H(+) + S-adenosyl-L-homocysteine => 1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56665", "l": "7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) => 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.37", "l": "\"2',3'-cyclic-nucleotide 3'-phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50872", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 = (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351207", "l": "Spermine  => N-acetylated spermine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31724", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] => (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36205", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218836", "l": "PTK2beta binds alphaVbeta3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32987", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77543", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53166", "l": "a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44671", "l": "4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol <=> 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62055", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphate + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856223", "l": "B4GALNT1 dimer transfers GalNAc to gangliosides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71849", "l": "LDH tetramer reduces PYR to LACT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362459", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70613", "l": "GOT2 transaminates OA and L-Glu (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37451", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + eicosanoyl-CoA = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14788", "l": "RNA(n) + UTP <=> diphosphate + RNA(n)-3'-uridine ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17797", "l": "[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.29", "l": "\"cellulose synthase (GDP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46019", "l": "(20R)-20-hydroxypregn-4-en-3-one + NAD(+) <=> H(+) + NADH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28601", "l": "H2O + N-acetyl-L-lysine <=> acetate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428917", "l": "G13 activation by TP receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36491", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34415", "l": "(1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28422", "l": "(1E,2S)-2-methylbutanal oxime + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylbutanenitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694409", "l": "Nucleotide exchange on RAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050490", "l": "1,4-lactonase activity", "d": ["Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75299", "l": "NAD(+) = 2'cADPR + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57584", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.162", "l": "\"flavanone 2-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27922", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.30", "l": "\"phycobiliprotein beta-cysteine-155 phycobilin lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27287", "l": "(S)-acetoin + NAD(+) => diacetyl + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987120", "l": "JAK1 binds IFNLR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140545", "l": "ATP-dependent protein disaggregase activity", "d": ["An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9824874", "l": "OPTN recruits CYLD to the TNFR1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28176", "l": "colneleate + H2O => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2681667", "l": "TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10039", "l": "4-hydroxy-3-methoxy-benzenemethanol + O2 <=> H2O2 + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62578", "l": "ADP + H(+) + L-cystine(in) + phosphate => ATP + H2O + L-cystine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878815", "l": "Formation of 4Fe-4S cluster on ISCA1:ISCA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349593", "l": "Interaction of integrin alphaIIbbeta3 with Fibronectin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19567", "l": "diphosphate + sabinene hydrate => (2E)-geranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089710", "l": "endocytic targeting sequence binding", "d": ["Binding to a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218645", "l": "SRC-1 binds p-Y397-PTK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9823904", "l": "TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21639", "l": "(E)-4-coumarate + UDP-alpha-D-glucose <=> 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63913", "l": "6-azauridine + ATP => 6-azauridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199131", "l": "PVR binds CD226 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37696", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA => 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15926", "l": "dihydrobunolol + NADP(+) => bunolol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54212", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77016", "l": "(S)-leucinol + H2O + NAD(+) => 1-hydroxy-4-methylpentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29219", "l": "a menaquinone + sn-glycerol 3-phosphate = a menaquinol + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2562526", "l": "PLK1 phosphorylates OPTN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78896", "l": "a very long-chain fatty acyl-CoA + acetyl-CoA => a very-long-chain 3-oxoacyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433415", "l": "Activation of RAC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42971", "l": "cytidine(56) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.8", "l": "\"clostripain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49791", "l": "chenodeoxycholoyl-CoA + glycine <=> CoA + glycochenodeoxycholate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008770", "l": "[acyl-carrier-protein] phosphodiesterase activity", "d": ["Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690702", "l": "LYN phosphorylates CD22 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15768", "l": "adenosylcob(III)inamide + GTP <=> adenosylcob(III)inamide phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.75", "l": "\"3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340560", "l": "PORCN-inhibitor LGK974 prevents WNT ligand palmitoyltation and secretion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417896", "l": "P2Y6 receptor can bind to UDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32947", "l": "a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47818", "l": "9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+) => H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18594", "l": "sphinganine 1-phosphate => hexadecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40381", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+) => 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0016726", "l": "oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP."], "t": []}, {"i": "EC:1.17.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390886", "l": "HRH4 binds Hist (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19974", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => H(+) + S-methyl-5'-thioadenosine + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61389", "l": "ATP + biotin(in) + H2O => ADP + biotin(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75098", "l": "2 chloride(in) + oxalate(out) <=> 2 chloride(out) + oxalate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695838", "l": "Ligand-independent dimerization of FLT3 mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17109", "l": "FMNH2 + N-methylnicotinate + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874718", "l": "TTPA binds alpha-TOH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3968414", "l": "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19135", "l": "3,5,3'-triiodothyropyruvate + L-glutamate => 2-oxoglutarate + 3,3',5-triiodo-L-thyronine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25021", "l": "CTP + riboflavin = CDP + FMN + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.161", "l": "\"CTP-dependent riboflavin kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839402", "l": "TGFBR3 binding to GIPC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27653", "l": "GTP + uridine <=> GDP + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390929", "l": "HTR1 and 5A receptors can bind serotonin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005362", "l": "low-affinity glucose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}, {"i": "REACT:R-HSA-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14015", "l": "adenosine 3',5'-bisphosphate + H(+) + taurolithocholate 3-sulfate => 3'-phosphoadenylyl sulfate + taurolithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38197", "l": "estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63831", "l": "L-alanine + vanillin <=> pyruvate + vanillylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53578", "l": "20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16306", "l": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O => 3-hydroxy-3-methylglutarate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1011598", "l": "DOCKs bind to RhoGEFs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34287", "l": "2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60816", "l": "2-oxoglutarate + gibberellin A14 aldehyde + O2 = CO2 + gibberellin A14 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28272", "l": "CoA + H(+) + N(8)-acetylspermidine => acetyl-CoA + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098608", "l": "methylselenol demethylase activity", "d": ["Catalysis of the reaction: methylselenol + H2O => H2Se + CH3OH."], "t": []}, {"i": "REACT:R-HSA-2408530", "l": "MeSeH is hydrolysed to H2Se by methylselenol demethylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033225", "l": "ATPase-coupled 2-aminoethylphosphonate transporter activity", "d": ["Enables the directed movement of 2-aminoethylphosphonate from one side of a membrane to the other by catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in)."], "t": []}, {"i": "RHEA:32775", "l": "(2-aminoethyl)phosphonate(out) + ATP + H2O = (2-aminoethyl)phosphonate(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47458", "l": "3-oxo-(5Z-tetradecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(5Z-tetradecenoyl)-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917700", "l": "MVB Vesicle Formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015558", "l": "secondary active p-aminobenzoyl-glutamate transmembrane transporter activity", "d": ["Enables the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2168888", "l": "Alpha1-Microglobulin binds heme (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236972", "l": "Escape of antigens from phagosome to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22745", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46844", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008892", "l": "guanine deaminase activity", "d": ["Catalysis of the reaction: guanine + H2O = xanthine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22565", "l": "a 2,3-saturated acyl-[ACP] + NADP(+) => a (2E)-enoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76540", "l": "a fatty acyl-CoA + sphinga-(4E,8E)-dienine => an N-acyl-sphinga-4,8-dienine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40499", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047800", "l": "cysteamine dioxygenase activity", "d": ["Catalysis of the reaction: cysteamine + O2 = H+ + hypotaurine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70094", "l": "ethanol + o-quinone methide <=> hydroxyclavatol ethyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418172", "l": "F2R binds ARRB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62078", "l": "6-phospho-D-galactono-1,5-lactone + H(+) + NADH => D-galactose 6-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50983", "l": "prostaglandin E1(out) <=> prostaglandin E1(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33477", "l": "a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29406", "l": "6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + AH2 + O2 <=> 3-demethylubiquinol-8 + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14785", "l": "RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide", "d": [], "t": []}, {"i": "EC:2.7.7.52", "l": "\"RNA uridylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53878", "l": "ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate => a cytidine in tRNA + acetyl-CoA + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42544", "l": "uridine(32) in tRNA = pseudouridine(32) in tRNA", "d": [], "t": []}, {"i": "EC:5.4.99.28", "l": "\"tRNA pseudouridine(32) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56361", "l": "13-deoxycarminomycin + H(+) + NADPH + O2 => 13-dihydrocarminomycin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66363", "l": "(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA + H2O <=> (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17367", "l": "ADP + H(+) + Mn(2+)(in) + phosphate => ATP + H2O + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56446", "l": "2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38241", "l": "1-O-(9Z)-octadecenyl (9Z)-octadecenoate + CoA => (9Z)-octadecen-1-ol + (9Z)-octadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001972", "l": "retinoic acid binding", "d": ["Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2186607", "l": "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27353", "l": "4'-demethylrebeccamycin + S-adenosyl-L-methionine = H(+) + rebeccamycin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.164", "l": "\"demethylrebeccamycin-D-glucose O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667965", "l": "ANKLE2 binds PP2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52976", "l": "a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32970", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60790", "l": "CO2 + gibberellin A9 + H2O => gibberellin A24 + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42830", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55074", "l": "CO2 + propanal => 2-oxobutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-264435", "l": "Dissociation of the COP1-p53 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877493", "l": "TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9825751", "l": "HINT1 binds MITF-M (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015194", "l": "L-serine transmembrane transporter activity", "d": ["Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21667", "l": "4-nitrophenyl phosphate + H2O <=> 4-nitrophenol + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.13", "l": "\"N(1)-acetylpolyamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.69", "l": "\"bontoxilysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72095", "l": "Internal Methylation of mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48242", "l": "a ganglioside GT1b + CMP + H(+) => a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31340", "l": "acetate + ATP + holo-[ACP] => acetyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62135", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dTTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21228", "l": "alpha-maltose = beta-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265301", "l": "Corticotropin cleavage from POMC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134914", "l": "Beta-catenin migrates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69069", "l": "AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline => A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44764", "l": "2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25009", "l": "N-hydroxy-L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-873917", "l": "Translocation of STAT1 dimer to nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982017", "l": "Active G alpha (q) binds RGS proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60678", "l": "(S)-(-)-citronellal + H(+) + NADH => (S)-(-)-citronellol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21929", "l": "3-dehydro-L-gulonate + NADP(+) => 2,3-dioxo-L-gulonate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0016502", "l": "nucleotide receptor activity", "d": ["Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28406", "l": "H2O + XTP = H(+) + phosphate + XDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202604", "l": "Formation of a heteromeric BMP receptor complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1168376", "l": "STIM1 oligomerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022398", "l": "ACE:Zn2+ hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49514", "l": "phosphinomethylisomalate => 2-(phosphinatomethylidene)butanedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008817", "l": "corrinoid adenosyltransferase activity", "d": ["Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52078", "l": "(9Z)-hexadecenoate + 13-hydroxy-octadecanoate + H(+) => 13-(9Z-hexadecenoyloxy)-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46849", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) => 5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23626", "l": "a uridine in tRNA + H(+) + NADPH => a 5,6-dihydrouridine in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72581", "l": "(22S)-hydroxy-3-oxo-chol-4-ene-24-oyl-CoA => (22E)-3-oxochola-4,22-dien-24-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047954", "l": "glycerol-2-phosphatase activity", "d": ["Catalysis of the reaction: glycerol 2-phosphate + H2O = glycerol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641229", "l": "TLE oligomerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109624", "l": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6783880", "l": "PIPOX oxidises PPCA to P6C (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11103", "l": "4-hydroxyhexan-3-one <=> 2 propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43826", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654571", "l": "Activated FGFR1 binds FRS3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48192", "l": "(9E)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9E)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750001", "l": "GLYAT-like proteins transfer glycine to 2,5-DHB-CoA to form gentisuric acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266299", "l": "Spherical HDL binds membrane-associated free cholesterol and phospholipids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17358", "l": "O2 + 2 R'C(R)SH => H2O2 + R'C(R)S-S(R)CR'", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420243", "l": "GHRH receptor binds GHRH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204773", "l": "Interaction of Tie2 and Grb7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36151", "l": "(E)-cinnamyl alcohol + acetyl-CoA = (E)-cinnamyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68590", "l": "(6S)-5,6,7,8-tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine + H(+) => (6R)-10-formyltetrahydrofolate + GDP-alpha-D-perosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832665", "l": "HNF1B binds the HNF4A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0035198", "l": "miRNA binding", "d": ["Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16082", "l": "(2R)-S-methyl-3-phospho-1-thioglycerate + H2O => (2R)-S-methyl-1-thioglycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17682", "l": "3-hydroxy-2-methylpropanoate + NAD(+) => 2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57136", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32356", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose => 2 H(+) + ternatin C5 + 2 UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16442", "l": "H2O + L-glutaminyl-[protein] => L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210282", "l": "Interaction of GPVI and FceRI gamma (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866277", "l": "AP-2 directly binds some endocytic cargo (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67284", "l": "(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione = (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9681616", "l": "AP2 binds chlorpromazine (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62050", "l": "an N-aryl-1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate => an N-aryl-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32847", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycerol = a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70613", "l": "H(+) + holo-[ACP] + N(6)-tetradecanoyl-L-lysyl-[protein] => L-lysyl-[protein] + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936058", "l": "miR-675 binds RUNX1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73077", "l": "H(+) + luteolin 7-methyl ether + S-adenosyl-L-homocysteine => luteolin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667456", "l": "AVPR1A,B bind desmopressin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14962", "l": "H2O + S-formylglutathione => formate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2173781", "l": "MARCO (SCARA2) binds ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68655", "l": "2 L-homocysteine <=> H(+) + hydrogen sulfide + L-homolanthionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63420", "l": "2-hydroxyethylphosphonate + CTP = cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.104", "l": "\"2-hydroxyethylphosphonate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58709", "l": "rifampicin ortho-naphthoquinone carboxamide => rifampicin para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018526", "l": "2-aminobenzoyl-CoA reductase activity", "d": ["Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2024100", "l": "GLCE epimerises GlcA to IdoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265177", "l": "Exocyst complex formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41776", "l": "CMP-N-acetyl-beta-neuraminate + ganglioside GA2 (d18:1(4E)/18:0) = CMP + ganglioside GM2 (d18:1(4E)/18:0) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67328", "l": "(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione = trichosetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.617342965326642", "identifiers": [{"i": "GO:0097472", "l": "cyclin-dependent protein kinase activity", "d": ["Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160874", "l": "HYAL1 hydrolyses (HA)50 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10716", "l": "D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate", "d": [], "t": []}, {"i": "EC:5.5.1.4", "l": "\"inositol-3-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868071", "l": "Clathrin recruits PIK3C2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31641", "l": "H(+) + mycinamicin IV + S-adenosyl-L-homocysteine => mycinamicin III + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163595", "l": "2-acylglycerol + H2O -> glycerol + fatty acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043872", "l": "lysine:cadaverine antiporter activity", "d": ["Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205231", "l": "Dimerization of KIT upon SCF binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56188", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78119", "l": "a 1,3-diacyl-2-(9Z,12Z-octadecadienoyl)-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base = a 1,3-diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52597", "l": "lithocholoyl-CoA + NAD(+) => 3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44703", "l": "a 2,3-saturated acyl-CoA + FAD + H(+) <=> a (2E)-enoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33076", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine => 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54454", "l": "a uridine in tRNA + H(+) + NADH => a 5,6-dihydrouridine in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.9.1", "l": "\"iron:rusticyanin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64359", "l": "2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 <=> (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.12", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64080", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O = 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71392", "l": "16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) => 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005137", "l": "interleukin-5 receptor binding", "d": ["Binding to an interleukin-5 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40842", "l": "FAD + H(+) + nonanoyl-CoA <=> (2E)-nonenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44939", "l": "(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228408", "l": "Retrograde transport of internalized tetX HC:LC:gangliosides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381466", "l": "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55484", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36816", "l": "dTDP-alpha-D-fucose => dTDP-alpha-D-fucofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10575", "l": "vinylacetyl-CoA <=> (2E)-butenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2160874", "l": "HYAL1 hydrolyses (HA)50 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196964", "l": "RFK:Mg2+ phosphorylates RIB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37192", "l": "2',3'-cyclophospho-AMP + H2O => adenosine 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48230", "l": "a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] => a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645692", "l": "C1QBP promotes translocation of p14ARF to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71775", "l": "SUCLG1/G2 cleaves succinyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41805", "l": "3-oxobutanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxybutanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39982", "l": "(+-)-pavine + S-adenosyl-L-methionine <=> H(+) + N-methylpavine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74992", "l": "Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5218805", "l": "PKC autophosphorylates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18149", "l": "H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047275", "l": "glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = D-galactosyl-N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033809", "l": "anthocyanin 6''-O-malonyltransferase activity", "d": ["Catalysis of the reaction: malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855648", "l": "SALM3 binds LAR-RPTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27298", "l": "2-formylbenzoate + H2O + NAD(+) = 2 H(+) + NADH + phthalate", "d": [], "t": []}, {"i": "EC:1.2.1.78", "l": "\"2-formylbenzoate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67099", "l": "2-oxoglutarate + asnovolin A + 2 O2 <=> CO2 + fumigatonoid A + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14157", "l": "H2O + triphosphate = diphosphate + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.25", "l": "\"triphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54612", "l": "2-oxoglutarate + 3-methylbutanoyl-CoA + O2 = 2-hydroxy-3-methylbutanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38129", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57178", "l": "N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] => L-arginyl-[protein] + methylglyoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0106130", "l": "purine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: RMP + diphosphate = R + 5-phospho-alpha-D-ribose 1-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12192", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.166", "l": "\"(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59364", "l": "1-octadecanoyl-2-(9,10-epoxyoctadecanoyl)-sn-glycero-3-phospho-L-serine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoserine + 9,10-epoxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25150", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde <=> H(+) + H2O + quinolinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191763", "l": "snRNP:Snurportin complex formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0009009", "l": "site-specific recombinase activity", "d": ["Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050132", "l": "N-methylalanine dehydrogenase activity", "d": ["Catalysis of the reaction: N-methyl-L-alanine + H2O + NADP+ = H+ + methylammonium + NADPH + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20293", "l": "3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022368", "l": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-42) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162195", "l": "COQ4 decarboxylates MHDB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205244", "l": "Recruitment of CBL to KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54077", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => diphosphate + stellata-2,6,19-triene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77306", "l": "N(omega),N(omega)-dimethyl-L-arginine + pyruvate <=> 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.99.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70425", "l": "a carboxylate + CoA + H(+) => an acyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77400", "l": "hydrogen cyanide + pentanal => (2S)-2-hydroxyhexanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17144", "l": "glycine + oxaloacetate <=> glyoxylate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77764", "l": "a 3'-end ribonucleotidyl-ribonucleotide-RNA + H2O => a 3'-end ribonucleotide-RNA + a ribonucleoside 5'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31899", "l": "indole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.153", "l": "\"indole-2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036188", "l": "abieta-7,13-dien-18-al dehydrogenase activity", "d": ["Catalysis of the reaction: abieta-7,13-diene-18-al + H2O + NAD+ = abieta-7,13-diene-18-oate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004311", "l": "farnesyltranstransferase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222399", "l": "Iron is reduced and separates from mycobactin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71962", "l": "3 Na(+)(out) + oxaloacetate(out) <=> 3 Na(+)(in) + oxaloacetate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426155", "l": "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72301", "l": "3,3',5-triiodo-L-thyronine(in) + L-glutamate(out) => 3,3',5-triiodo-L-thyronine(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004505", "l": "phenylalanine 4-monooxygenase activity", "d": ["Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28397", "l": "L-alanyl-L-glutamate <=> L-alanyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46332", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.22", "l": "\"acyl-lipid omega-6 desaturase (cytochrome b5)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030409", "l": "glutamate formimidoyltransferase activity", "d": ["Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11663", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O <=> acetate + an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102814", "l": "caffeoyl-CoA:delphinidin-3,5,3'-triglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: delphinidin 3,3',5-tri-O-beta-D-glucoside betaine + caffeoyl-CoA = delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51726", "l": "adenosine 5'-tetraphosphate + ADP + 2 H(+) => H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65402", "l": "butyl butanoate + CoA => butan-1-ol + butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354097", "l": "Activation of Talin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43196", "l": "adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848339", "l": "PNPLA5 hydrolyzes TAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814153", "l": "ADO oxidises 2AET to HTAU (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987043", "l": "IL22RA1 binds JAK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25365", "l": "H(+) + momilactone A + NADH => 3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2294590", "l": "PLK1 binds phosphorylated condensin II complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212356", "l": "Formation of CSL-NICD coactivator complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40939", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH = 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106373", "l": "3-deoxyglucosone dehydrogenase activity", "d": ["Catalysis of the reaction: 3-deoxyglucosone + H2O + NAD+ = 2-dehydro-3-deoxy-D-gluconate + 2 H+ + NADH."], "t": []}, {"i": "RHEA:67244", "l": "3-deoxyglucosone + H2O + NAD(+) = 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60857", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56595", "l": "a disubstituted aliphatic (S)-hydroxynitrile <=> a ketone + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173723", "l": "C8 binds C5b:C6:C7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13680", "l": "D-ribulose 5-phosphate <=> D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030739", "l": "O-demethylpuromycin O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690461", "l": "FKBP1A binds tacrolimus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68059", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O <=> a 3'-end 3'-phospho-ribonucleotide-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43770", "l": "N(5)-alkyl-L-glutaminyl-[protein] + NH4(+) => an alkylamine + L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31336", "l": "CTP + H(+) + Mo-molybdopterin => diphosphate + Mo-molybdopterin cytosine dinucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161791", "l": "15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59471", "l": "an S-substituted glutathione + H2O <=> an S-substituted L-cysteinylglycine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351407", "l": "Association of MRE11 with RAD50 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3878123", "l": "Initiation of SAHF formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247493", "l": "PIAS1 SUMOylates SP3 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72936", "l": "(S)-lactate(out) + 2 Na(+)(out) => (S)-lactate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604712", "l": "Initial activation of proMMP7 by trypsin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75786", "l": "ADP(in) <=> ADP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33380", "l": "4-hydroxyeicosasphinganine 1-phosphate + H2O => (4R)-hydroxyeicosasphinganine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57354", "l": "H(+) + H2O + lutein + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + zeinoxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71669", "l": "malonate(in) + succinate(out) => malonate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25696", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45640", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446077", "l": "BP230 interacts with keretin K5/K14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10722", "l": "6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione => 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-383190", "l": "HCO3- transport through ion channel (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77731", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol = 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102435", "l": "myricetin 7-O-methyltransferase activity", "d": ["Catalysis of the reaction: myricetin(1-) + S-adenosyl-L-methionine = 7-O-methylmyricetin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14146", "l": "ATP + guanidinoacetate => ADP + H(+) + phosphoguanidinoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77513", "l": "(2S)-2-hydroxy-2-(2-methoxyphenyl)acetonitrile => 2-methoxybenzaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168643", "l": "SCF-beta-TrCP ubiquitinylates IkB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964284", "l": "BTK in active Gq-BTK complex is activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56159", "l": "(12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74967", "l": "a (3R)-3-isocyanyl-fatty acid + ATP + H(+) = a (3R)-3-isocyanyl-fatty acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981622", "l": "Myoglobin:oxygen dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27744", "l": "2-deoxy-alpha-D-ribose 1-phosphate + adenine => 2'-deoxyadenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40883", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58135", "l": "A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase] <=> AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41553", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + ophiobolin F", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25661", "l": "(R)-pulegone + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-menthofuran + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56441", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160153", "l": "mitochondrial tRNA pseudouridine(27/28) synthase activity", "d": ["Catalysis of the reaction: uridine(27/28) in mitochondrial tRNA = pseudouridine(27/28) in mitochondrial tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047570", "l": "3-oxoadipate enol-lactonase activity", "d": ["Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16431", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate => ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636564", "l": "SapM binds RAB7A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9842641", "l": "Active LTK receptor binds SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5675947", "l": "TNFSF18 binds TNFRSF18 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59141", "l": "ATP + citrate + N(5)-[(S)-citryl]-D-ornithine => AMP + diphosphate + H(+) + staphyloferrin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047625", "l": "S-adenosyl-L-methionine lyase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine = L-homoserine lactone + S-methyl-5'-thioadenosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19427", "l": "5-hydroxyimidazole-4-acetate + H2O + NAD(+) => H(+) + imidazole-4-acetate + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77549", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62152", "l": "dGMP + dTTP = dGDP + dTDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73234", "l": "2,4,6-trichlorophenol + FADH2 + O2 <=> 2-chloro-6-hydroxy-1,4-benzoquinone + 2 chloride + FAD + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76117", "l": "6-O-demethylthebaine + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + O2 + thebaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5695964", "l": "ABHD14B hydrolyses PNPB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420582", "l": "Necl-1:Nectin-1 trans heterodimer interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798044", "l": "BTG2 binds CCR4-NOT complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37026", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0036080", "l": "purine nucleotide-sugar transmembrane transporter activity", "d": ["Enables the transfer of a purine nucleotide-sugar from one side of a membrane to the other. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102512", "l": "delphinidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose = delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + vanillate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51917", "l": "(2S)-2-amino-3-butenoate + H2O => 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052808", "l": "reduced coenzyme F420:NADP+ oxidoreductase activity", "d": ["Catalysis of the reaction: NADP+ + 1,5-dihydrocoenzyme F420 = NADPH + H+ + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50036", "l": "choloyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0009931", "l": "calcium-dependent protein serine/threonine kinase activity", "d": ["Calcium-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67700", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77323", "l": "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21222", "l": "4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => L-dopa + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106318", "l": "methane monooxygenase NADPH activity", "d": ["Catalysis of the reaction: methane + NADPH + H+ + O2 = methanol + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140955", "l": "histone H3K36 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420233", "l": "VIP receptors bind VIP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56353", "l": "4-hydroxybenzoate + bromide + 2 H(+) + NADPH + O2 => 3-bromo-4-hydroxybenzoate + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821395", "l": "PAXIP1 binds PAGR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63978", "l": "AH2 + pyriculariol => A + dihydropyriculariol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40942", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH <=> 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682598", "l": "ATM phosphorylates HERC2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.752469279128519", "identifiers": [{"i": "GO:0016849", "l": "phosphorus-oxygen lyase activity", "d": ["Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond."], "t": []}, {"i": "EC:4.6.-.-", "l": "\"Phosphorus-oxygen lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.2.1.11", "l": "\"6-deoxy-5-ketofructose 1-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.34", "l": "\"lipoprotein lipase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0010852", "l": "cyclase inhibitor activity", "d": ["Binds to and decreases the activity of an enzyme that catalyzes a ring closure reaction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033907", "l": "beta-D-fucosidase activity", "d": ["Catalysis of the hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875183", "l": "CBL monoubiquitinates activated MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55241", "l": "1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O => (9Z)-octadecenoate + 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49208", "l": "20S-hydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 20S,24S-dihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047235", "l": "sucrose 6F-alpha-galactotransferase activity", "d": ["Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696357", "l": "LAIR2 binds collagen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74260", "l": "H2O + L-homoseryl-tRNA(Lys) => H(+) + L-homoserine + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67378", "l": "glycine + L-histidine => glycyl-L-histidine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24042", "l": "H(+) + NADP(+) + 2 reduced [cytochrome P450] => NADPH + 2 oxidized [cytochrome P450]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254251", "l": "ERBB4s80 binds YAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33852", "l": "GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) => GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944599", "l": "miR-93 microRNA binds PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22178", "l": "20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40254", "l": "4-O-methylrhodomycin D + H2O <=> 10-carboxy-13-deoxydaunorubicin + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.219", "l": "\"demethoxycurcumin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.323347803118935", "identifiers": [{"i": "GO:0051139", "l": "metal cation:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in)."], "t": []}, {"i": "REACT:R-HSA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8956684", "l": "ITCH polyubiquitinates TP73 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909552", "l": "Phosphorylation of STAT1 at Ser727 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004783", "l": "sulfite reductase (NADPH) activity", "d": ["Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004163", "l": "diphosphomevalonate decarboxylase activity", "d": ["Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO2 + H+ + isopentenyl diphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59859", "l": "Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + tetramethylammonium <=> methyl-Co(III)-[tetramethylammonium-specific corrinoid protein] + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708275", "l": "PDE4A binds PDE4A inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371591", "l": "Trimerization of cytosolic HSF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69377", "l": "2-hydroxydodecanoate + O2 => 2-oxododecanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45708", "l": "3-dehydrocarnitine + acetyl-CoA = 3-dehydrocarnityl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9705926", "l": "AR binds AR agonists (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72671", "l": "eIF5B:GTP is hydrolyzed and released (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28520", "l": "D-glycero-beta-D-manno-heptose 1-phosphate + phosphate => D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033411", "l": "UAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74842", "l": "UDP(in) + UDP-alpha-D-glucuronate(out) <=> UDP(out) + UDP-alpha-D-glucuronate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796056", "l": "NFkB binds the NFE2L2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48266", "l": "H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate => H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390598", "l": "Myosin Binds ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8960973", "l": "RLBP1:11cRAL dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.18.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9609310", "l": "β-blockers bind ADRB1,2,3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54129", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40825", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + octadecanoate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42116", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72223", "l": "4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out) = 4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167601", "l": "Degradation of CD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418850", "l": "Activation of Cdc42 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786072", "l": "p-Y705-STAT3,p-Y641-STAT6 dissociate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061710", "l": "L-threonylcarbamoyladenylate synthase", "d": ["Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201712", "l": "Beta-catenin:TCF associates with BCL9 and PYGO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.4.4", "l": "\"[ribosomal protein uS12] (aspartate(89)-C(3))-methylthiotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070905", "l": "serine binding", "d": ["Binding to 2-amino-3-hydroxypropanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75575", "l": "11-O-acetylcyathatriol + A = 11-O-acetylcyathin A3 + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781899", "l": "USP13 binds SIAH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606312", "l": "GLB1 hydrolyzes SapB/C:LacCer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53641", "l": "(2E,6E)-farnesyl diphosphate => (-)-alpha-amorphene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210430", "l": "Release of L-Glutamate at the synapse (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49880", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0008474", "l": "palmitoyl-(protein) hydrolase activity", "d": ["Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483218", "l": "PG transports from the ER membrane to the late endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19994", "l": "[thioredoxin]-disulfide + H2O + L-methionine => [thioredoxin]-dithiol + L-methionine (S)-S-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30621", "l": "2 AH2 + all-trans-lycopene => 2 A + all-trans-zeta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54755", "l": "methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n) <=> dihydromethanophenazine + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49905", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.323347803118935", "identifiers": [{"i": "GO:0016880", "l": "acid-ammonia (or amide) ligase activity", "d": ["Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004378", "l": "GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity", "d": ["Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24795", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate => 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832907", "l": "Expression of SOX1 in neural plate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36920", "l": "(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.139", "l": "\"umbelliferone 6-dimethylallyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68045", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140550", "l": "phosphatidylinositol-4,5-bisphosphate sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of phosphatidylinositol-4,5-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062158", "l": "chloride:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + proton(in) = chloride(in) + proton(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654625", "l": "Activated FGFR3 binds SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33080", "l": "6-amino-6-deoxyfutalosine + H2O => adenine + dehypoxanthine futalosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51651", "l": "H2O + N(6)-acetyl-L-lysyl-[protein] + O2 <=> (S)-2-amino-6-oxohexanoyl-[protein] + acetamide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696564", "l": "USP25 deubiquitinates DDX58 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42901", "l": "guanosine(745) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30253", "l": "2 a ubiquinone + n H(+)(out) + 2 H2O => 2 a ubiquinol + n H(+)(in) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60616", "l": "N-dodecanoyl-heptadecasphing-4-enine-1-phosphoethanolamine = ethanolamine + N-dodecanoyl-heptadecasphing-4-enine-1,3-cyclic phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41642", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate => 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951966", "l": "EP300 acetylates RUNX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30529", "l": "ADP + ATP + 2 H(+) => H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350598", "l": "Arginine<=>Agmatine+CO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467761", "l": "A2E is phagocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66576", "l": "3'-phosphoadenylyl sulfate + 4-isopropylphenol = 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51009", "l": "2 Fe(III)-[cytochrome cL] + methanol => 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2574845", "l": "AJUBA binds centrosome-associated AURKA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49877", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76628", "l": "(S)-2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) => H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18578", "l": "3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine => 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102218", "l": "starch, H2O dikinase activity", "d": ["Catalysis of the reaction: n ATP + n H2O + starch = n AMP + n hydrogenphosphate + a 6-phosphogluco-amylopectin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169421", "l": "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28136", "l": "(2S)-hesperetin + rutinose => (2S)-hesperidin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60788", "l": "gibberellin A24 + H(+) + O2 = CO2 + gibberellin A9 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41031", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + decanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-decanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251942", "l": "Hikeshi binds HSP70s:ATP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60827", "l": "H2O + P(1),P(2)-bis(5'-adenosyl) diphosphate <=> 2 AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951850", "l": "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44564", "l": "4-hydroxybenzoate + all-trans-decaprenyl diphosphate = 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75378", "l": "inosine(in) <=> inosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51498", "l": "a sphingoid 1-phosphate + ADP + H(+) => a sphingoid base + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40183", "l": "O2 + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29879", "l": "ATP + H2O + L-arginine(out) = ADP + H(+) + L-arginine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167115", "l": "Addition of nucleotides between position +11 and +30 on HIV-1 transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018806", "l": "RAC3 GAPs stimulate RAC3 GTPase activity (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25631", "l": "H(+) + laricitrin + S-adenosyl-L-homocysteine => myricetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61977", "l": "glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine => 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75221", "l": "H(+) + L-fuconate => H2O + L-fucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112604", "l": "Phosphorylated STATs are released (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678935", "l": "IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013023", "l": "RHOB GEFs activate RHOB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62371", "l": "Fe(2+)(out) + 2 hydrogencarbonate(out) <=> Fe(2+)(in) + 2 hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114552", "l": "Thrombin-activated PARs activate G12/13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75294", "l": "glyoxylate(in) + oxalate(out) <=> glyoxylate(out) + oxalate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989774", "l": "Expression of AGT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57557", "l": "(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36331", "l": "ATP + dimethylallyl diphosphate = diphosphate + N(6)-(dimethylallyl)adenosine 5'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159826", "l": "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32857", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174706", "l": "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31255", "l": "(2S)-2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52524", "l": "O2 + prostaglandin A1 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy prostaglandin A1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314686", "l": "ASA- acetylates PTGS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43963", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA <=> a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68695", "l": "3'-phosphoadenylyl sulfate + 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(beta-D-glucuronate) <=> 3alpha,17alpha-dihydroxy-5beta-androstane-11-one-17beta-carboxylate 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163320", "l": "Association of mTERF with the termination sequence (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52014", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034026", "l": "L-amino-acid alpha-ligase activity", "d": ["Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62002", "l": "3 AH2 + protoporphyrin IX => 3 A + protoporphyrinogen IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45720", "l": "N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47834", "l": "a ganglioside GM1 + N-acetylneuraminate => a ganglioside GD1a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43563", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29281", "l": "H2O + menaquinone-8 + trimethylamine => H(+) + menaquinol-8 + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0032067", "l": "type IV site-specific deoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36570", "l": "GDP-beta-L-colitose + NAD(+) <=> GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990444", "l": "F-box domain binding", "d": ["Binding to an F-box domain of a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111970", "l": "PKC phosphorylates GRK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211904", "l": "CYP4F12 18-hydroxylates ARA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16868", "l": "choloyl-CoA + propanoyl-CoA <=> 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186765", "l": "PLC-gamma binds to the active receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6805205", "l": "GPR35 binds kynurenic acid (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9621179", "l": "Cinaciguat binds sGC:NO (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162194", "l": "COQ7:COQ9 octamer hydroxylates DMQ10H2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38624", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954082", "l": "E2F6 binds the PRC1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75215", "l": "beta-L-fucose + NADP(+) = H(+) + L-fucono-1,5-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730692", "l": "CLCN4/5/6 exchange Cl- for H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20033", "l": "isopenicillin N = penicillin N", "d": [], "t": []}, {"i": "EC:5.1.1.17", "l": "\"isopenicillin-N epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433508", "l": "PKC alpha interacts with and phosphorylates KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220944", "l": "ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32690", "l": "(2E)-geranyl diphosphate <=> diphosphate + tricyclene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018461", "l": "fluoren-9-ol dehydrogenase activity", "d": ["Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70655", "l": "H(+)(in) + sarcosine(in) = H(+)(out) + sarcosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008046", "l": "axon guidance receptor activity", "d": ["Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109539", "l": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5628899", "l": "TP53 binds the TIGAR gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11745", "l": "H2O + thiamine triphosphate => H(+) + phosphate + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191830", "l": "snRNP nuclear import and release (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194130", "l": "Transport (influx) of bile salts and acids by OATP-A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43354", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol(out) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212007", "l": "CYP26A1,B1 4-hydroxylate atRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53614", "l": "CDP-D-ribulose + diphosphate => CTP + D-ribulose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45839", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-4-phosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678327", "l": "MIOX oxidises Ins to GlcA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4793956", "l": "Defective B4GALT1 does not add Gal to N-glycan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22284", "l": "2 H(+) + H2O + N-carbamoylputrescine = CO2 + NH4(+) + putrescine", "d": [], "t": []}, {"i": "EC:3.5.1.53", "l": "\"N-carbamoylputrescine amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697423", "l": "Endocytosis of SARS-CoV-2 Virion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23976", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.5.1.4", "l": "\"RNA 3'-terminal-phosphate cyclase (ATP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1504193", "l": "Ubiquitinated DVL is degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8873946", "l": "OTUD3 deubiquitinates PTEN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2002428", "l": "Removal of fibrillar collagen N-propeptides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13069", "l": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine", "d": [], "t": []}, {"i": "EC:2.7.1.82", "l": "\"ethanolamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418925", "l": "ADORA2A,B bind Ade-Rib (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782820", "l": "USP17 deubiquitinates SUDS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839751", "l": "YME1L1 degrades mitochondrial intermembrane space proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114264", "l": "Translocation of activated BAX to the mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199910", "l": "MSK1 activates ATF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703439", "l": "FLT3 fusions recruit PIK3R1 through phosphorylated GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40660", "l": "1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol => 1-O-hexadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48945", "l": "ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate => 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690493", "l": "RHOB binds effectors on endosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.353", "l": "\"versiconal hemiacetal acetate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52095", "l": "5-(9Z-hexadecenoyloxy)-octadecanoate + H2O <=> (9Z)-hexadecenoate + 5-hydroxy-octadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33926", "l": "(1R,4R)-5-oxo-1,2-campholide <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67248", "l": "(E)-4-hydroxynon-2-enal + H2O + NAD(+) = (E)-4-hydroxynon-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45966", "l": "2 AMP + ATP + 2 H(+) => 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15790", "l": "L-xylose + NADP(+) => H(+) + L-xylono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45046", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrite => 2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729849", "l": "SARS-CoV-2 nsp1 binds to 40S ribosomal complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75849", "l": "SLC25A1 exchanges CIT and MAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0033946", "l": "xyloglucan-specific endo-beta-1,4-glucanase activity", "d": ["Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the endohydrolysis of (1->4)-beta-D-glucosidic linkages in xyloglucan."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615626", "l": "PMP22 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64956", "l": "dTTP + 2 H2O = dTMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38049", "l": "a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76922", "l": "4-methyl-cyclohexylamine + H2O + NADP(+) <=> 4-methylcyclohexanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70495", "l": "D-glucose(out) + 2 Na(+)(out) = D-glucose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9835358", "l": "p-TARBP2 binds PKR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75938", "l": "ATP + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine <=> 6-O-phospho-N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56950", "l": "H(+) + phosphoenolpyruvate + UDP => pyruvate + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6781867", "l": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793685", "l": "Ubiquitinated TP53 translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102117", "l": "gibberellin A9 carboxyl methyltransferase activity", "d": ["Catalysis of the reaction: gibberellin A9 + S-adenosyl-L-methionine = gibberellin A9 methyl ester + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842649", "l": "Active LTK receptor binds PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015099", "l": "nickel cation transmembrane transporter activity", "d": ["Enables the transfer of nickel (Ni) cations from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448703", "l": "Interleukin-1 family precursors are cleaved by caspase-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63212", "l": "5-amino-6-(D-ribitylamino)uracil + methylglyoxal = 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67957", "l": "(S)-2-chloropropanoate + H2O => (R)-lactate + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35779", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = mutildienyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63109", "l": "16-hydroxy-ilicicolin A epoxide => ascofuranol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625796", "l": "Demethylase KDM4C binds KLK2 and KLK3 promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378975", "l": "Follitropin is a heterodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1524182", "l": "Activated PLC gamma dissociates from the PDGF receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45162", "l": "acetaldehyde + CO2 => 3-oxopropanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22610", "l": "(2S,6S)-2,6-diaminoheptanedioate + succinate => H2O + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482776", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175177", "l": "Association of  XRCC4:DNA ligase IV complex with viral DNA ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106347", "l": "U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity", "d": ["Catalysis of the reaction: a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+."], "t": []}, {"i": "RHEA:62672", "l": "a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14501", "l": "H2O + L-homocysteine = 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)", "d": [], "t": []}, {"i": "EC:4.4.1.2", "l": "\"homocysteine desulfhydrase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54029", "l": "a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70738", "l": "chloride(out) + glycine betaine(out) + 2 Na(+)(out) <=> chloride(in) + glycine betaine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70107", "l": "(S)-5-carboxymethyl-tetronate + o-quinone methide = H(+) + penilactone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53811", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50226", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-hexaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1254251", "l": "ERBB4s80 binds YAP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69994", "l": "3-dehydro-6-deoxoteasterone + NADP(+) <=> (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52463", "l": "17beta-estradiol + UDP-alpha-D-glucuronate <=> 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33658", "l": "(9Z)-octadecenoate(out) <=> (9Z)-octadecenoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213017", "l": "Auto-ubiquitination of TRAF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78465", "l": "an isogloboside iGb3Cer + H(+) + UDP => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22236", "l": "2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.68", "l": "\"2-deoxyglucose-6-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419389", "l": "LPA-binding receptors bind LPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856951", "l": "PP2A demethylation by PPME1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47901", "l": "a ganglioside GM3 (d18:1(4E)) + H2O => a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71268", "l": "chloride(out) + L-pipecolate(out) + 2 Na(+)(out) => chloride(in) + L-pipecolate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60135", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 <=> a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49229", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + bacteriochlorophyllide a + H(+) => diphosphate + geranylgeranyl-bacteriochlorophyllide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25911", "l": "an alditol + O2 <=> an aldose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851888", "l": "MET binds SHC1-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102883", "l": "(+)-beta-chamigrene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-beta-chamigrene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34279", "l": "di-trans,poly-cis-dolichol + NADP(+) = di-trans,cis-polyprenol + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.94", "l": "\"polyprenol reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389523", "l": "BTLA interacts with HVEM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46693", "l": "4-hydroxybenzoate + ATP + H(+) => 4-hydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18510", "l": "H(+) + H2O2 + NADH => 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9834807", "l": "ILF3 binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061899", "l": "11-cis-retinal 3,4-desaturase activity", "d": ["Catalysis of the reaction: 11-cis-retinal + 2 H+ + O2 + 2 reduced [adrenodoxin] = 11-cis-3,4-didehydro-retinal + 2 H2O + 2 oxidized [adrenodoxin]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21629", "l": "17alpha-hydroxyprogesterone + NADPH + O2 => acetate + androst-4-ene-3,17-dione + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58187", "l": "H(+) + NADPH + 2 phytyl diphosphate <=> (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607734", "l": "PKC-delta translocates to plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71724", "l": "H(+)(out) + L-alanyl-L-leucyl-L-alanine(out) => H(+)(in) + L-alanyl-L-leucyl-L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983162", "l": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63042", "l": "H(+) + lovastatin carboxylate => H2O + lovastatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52883", "l": "16beta,17beta-estriol + UDP-alpha-D-glucuronate <=> 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051287", "l": "NAD binding", "d": ["Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442739", "l": "PDPK1 phosphorylates RSKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149433", "l": "Synthesis of VPU protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654422", "l": "Activated FGFR4 binds FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690988", "l": "3'-incision of DNA by ERCC5 (XPG) in GG-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29210", "l": "a menaquinol(in) + dimethyl sulfoxide(out) <=> a menaquinone(in) + dimethyl sulfide(out) + H2O(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23188", "l": "NAD(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.202", "l": "\"1,3-propanediol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36192", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + choline => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202969", "l": "Caspase mediated cleavage of beta-catenin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.218", "l": "\"alpha-3'-ketoglucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41897", "l": "(2E)-tetradecenoyl-[ACP] + H(+) + NADPH => NADP(+) + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9825772", "l": "SIRT1 deacetylates HINT1 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380930", "l": "Phosphorylated AMPK binds AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035486", "l": "cytosine/cytosine mispair binding", "d": ["Binding to a double-stranded DNA region containing a C/C mispair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55927", "l": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694406", "l": "nsp13 binds DDX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-437085", "l": "ZnT5 transports zinc into secretory granules in pancreatic beta cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61589", "l": "amicoumacin A + ATP => ADP + amicoumacin A 2-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54379", "l": "(+)-copalyl diphosphate + H2O <=> diphosphate + nezukol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032141", "l": "single cytosine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single cytosine insertion or a deletion that results in an unpaired cytosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30798", "l": "2-oxoadipate + CoA + NAD(+) <=> CO2 + glutaryl-CoA + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43562", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2230983", "l": "LRP1:Hemopexin:heme is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9663511", "l": "BIL binds GSTA1, FABP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805059", "l": "CK2:FACT phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77083", "l": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10867", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 <=> 2-(acetamidomethylene)succinate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0004602", "l": "glutathione peroxidase activity", "d": ["Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9017491", "l": "RHOJ GEFs activate RHOJ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417829", "l": "P2RY12 binds ADP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30526", "l": "GTP + L-glutamate + oxidized coenzyme F420-1 <=> GDP + H(+) + oxidized coenzyme F420-2 + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047339", "l": "nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity", "d": ["Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787540", "l": "FUK phosphorylates beta-Fuc to Fuc1P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24071", "l": "cyclohexanone + H(+) + NADPH + O2 <=> H2O + hexano-6-lactone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22929", "l": "4-acetamidobutanoyl-CoA + H2O => 4-aminobutanoyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12330", "l": "[(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate => [(1->3)-alpha-D-glucosyl](n) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15055", "l": "(6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6R)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869241", "l": "PITPNM1,2,3 exchange PI for PA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604752", "l": "Initial activation of proMMP13 by MMP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65991", "l": "previtamin D3 <=> calciol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22211", "l": "3-hydroxyphenylacetate + H(+) + NADH + O2 <=> H2O + homogentisate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67366", "l": "L-serine + L-threonine => H2O + L-threonyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33183", "l": "citrate(in) = citrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61291", "l": "5-deoxy-D-ribose + ATP <=> 5-deoxy-alpha-D-ribose 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75474", "l": "thiamine diphosphate(out) <=> thiamine diphosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112437", "l": "Formation of NELF complex  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0043225", "l": "ATPase-coupled inorganic anion transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58794", "l": "ADP + Fe(III)-petrobactin(in) + H(+) + phosphate => ATP + Fe(III)-petrobactin(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0005229", "l": "intracellularly calcium-gated chloride channel activity", "d": ["Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046863", "l": "ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity", "d": ["Binds to and iincreases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5229273", "l": "LCN2:2,5DHBA binds Fe3+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874685", "l": "CBL binds MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16068", "l": "2-oxoglutarate + O2 + phytanoyl-CoA <=> 2-hydroxyphytanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49537", "l": "2-amino-2-deoxy-D-gluconate => (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83660", "l": "Membrane-anchored TNF-α binds TNFR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15943", "l": "acetate + L-ornithine => H2O + N(2)-acetyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66475", "l": "(2Z,6E,10E,14E)-geranylfarnesol <=> 18-episcalar-17(25)-en-19-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65052", "l": "4-(trifluoromethyl)benzyl alcohol + NAD(+) = 4-(trifluoromethyl)benzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193669", "l": "TRAF6 binds to p75NTR:NRIF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008797", "l": "aspartate ammonia-lyase activity", "d": ["Catalysis of the reaction: L-aspartate = fumarate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250348", "l": "Phosphorylation of SHC1 by ERBB4 homodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54606", "l": "2-hydroxydecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + decanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31307", "l": "a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.265", "l": "\"dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73949", "l": "(4E,6E)-allo-ocimene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65535", "l": "2-methylbutan-1-ol + hexanoyl-CoA <=> 2-methylbutyl hexanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35020", "l": "L-threonine(in) => L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0016872", "l": "intramolecular lyase activity", "d": ["The catalysis of certain rearrangements of a molecule to break or form a ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865482", "l": "KMT2A (MLL) binds RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031798", "l": "type 1 metabotropic glutamate receptor binding", "d": ["Binding to a type 1 metabotropic glutamate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685319", "l": "CX3 complex formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9769235", "l": "MAGED1 binds NPAS4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71676", "l": "GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67319", "l": "(2S,4R)-4-hydroxy-4-methylglutamate + ATP + 11 H(+) + 8 malonyl-CoA + 8 NADPH + 3 S-adenosyl-L-methionine <=> (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 8 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102522", "l": "tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 4-demethylwyosine37 in tRNAPhe = 5'-S-methyl-5'-thioadenosine + H+ + 7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782069", "l": "UVSSA:USP7 deubiquitinates ERCC6 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.244991688848543", "identifiers": [{"i": "GO:0099095", "l": "ligand-gated monoatomic anion channel activity", "d": ["Enables the transmembrane transfer of an inorganic anion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56402", "l": "(3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56005", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111883", "l": "Hydrolysis of phosphatidylcholine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020261", "l": "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33611", "l": "H2O + methyl salicylate = H(+) + methanol + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183051", "l": "CBL ubiquitinates Sprouty (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52639", "l": "2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 <=> a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76568", "l": "3'-dehydrocarminate + H(+) => 1,5-anhydro-D-erythro-hex-1-en-3-ulose + kermesate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17440", "l": "2,4-dichloro-5-oxo-2,5-dihydro-2-furylacetate <=> (2E,4E)-2,4-dichloromuconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26226", "l": "abieta-7,13-dien-18-al + H2O + NAD(+) => abieta-7,13-dien-18-oate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36983", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9861734", "l": "PDH E1 decarboxylates PYR, transferring acetyl to DLAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-164834", "l": "Enzyme-bound ATP is released (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855187", "l": "IP6 transports from the nucleus to the ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158784", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626469", "l": "GTP-bound RAC1 and CDC42 bind IQGAPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53346", "l": "H(+) + NADPH + uridine(20a) in tRNA => 5,6-dihydrouridine(20a) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19557", "l": "AH2 + O2 + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.24", "l": "\"steroid 9alpha-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55891", "l": "[aequorin]--dioxetanone <=> [excited state blue fluorescent protein] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20926", "l": "a [peptide]-C-terminal amide + glyoxylate => a [peptide]-C-terminal (2S)-2-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37395", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983298", "l": "IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56743", "l": "a globoside Gb3Cer + UDP-alpha-D-galactose <=> a globoside GalGb3Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40225", "l": "4,8-dimethylnonanoate + CoA + H(+) => 4,8-dimethylnonanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36852", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.72", "l": "\"IgA-specific serine endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399939", "l": "Autophosphorylation of PAK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016463", "l": "P-type zinc transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) = ADP + phosphate + Zn2+(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13018", "l": "diphosphate + UMP => 5-phospho-alpha-D-ribose 1-diphosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-183126", "l": "Factor B binds to surface-associated C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159728", "l": "Furin cleaves pro-prothrombin to prothrombin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69774", "l": "a short-chain fatty aldehyde + H2O + NAD(+) <=> a short-chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351948", "l": "Mitochondrial recruitment of Drp1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913993", "l": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49535", "l": "4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O <=> ethylene glycol + H(+) + terephthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198714", "l": "ERK5 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76545", "l": "fumarate + N-acetyl-L-cysteine => N-acetyl-S-(2-succino)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635859", "l": "GLI:SUFU dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693347", "l": "HTR1A binds 5HT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35945", "l": "deoxybrevianamide E + diphosphate => brevianamide F + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5591040", "l": "Activated protein C cleaves Factor Va intermediate form for Factor Va (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37315", "l": "glycyl-L-glutamine + H2O = glycine + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54240", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097099", "l": "structural constituent of albumen", "d": ["The action of a molecule that contributes to the structural integrity of albumen (also called egg white). Albumen is the clear liquid contained within an egg and consists of water and proteins, among which are ovomucin and ovomucoid. It protects the egg yolk and provides additional nutrition for the growth of the embryo."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49255", "l": "D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-fructose 1-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3149519", "l": "MMACHC decyanates CNCbl (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77161", "l": "H(+) + N-acetyl-1-seleno-beta-D-glucosamine + phosphate + UDP => H2O + selenophosphate + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47741", "l": "1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate => CO2 + demethylphylloquinone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54404", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 2-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51240", "l": "(9Z,12Z)-octadecadienoate + O2 = (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70994", "l": "SDH complex dehydrogenates succinate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0072341", "l": "modified amino acid binding", "d": ["Binding to a modified amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5617828", "l": "TRIP11:IFT20 dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0001069", "l": "regulatory region RNA binding", "d": ["Binding to a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928604", "l": "SFKs phosphorylate VAV2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851866", "l": "MET binds RANBP10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19244", "l": "ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42777", "l": "adenosine(1408) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(1408) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448673", "l": "Formation of caspase-1 p10/p20 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53756", "l": "allodeoxycholoyl-CoA + cholate = allodeoxycholate + choloyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873929", "l": "Casein kinase II phosphorylates STARD10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851089", "l": "NTPDase2 hydrolyzes nucleoside triphosphates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900747", "l": "NOTCH1 HD+PEST domain mutants bind DLL4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23716", "l": "(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39835", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27793", "l": "2-all-trans-octaprenylphenol + H(+) + NADPH + O2 <=> 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202709", "l": "JAM2 dimerises (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71203", "l": "L-homoarginine(in) = L-homoarginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9843978", "l": "CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17079", "l": "formaldehyde + H2O2 + sarcosine => H2O + N,N-dimethylglycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64023", "l": "GTP + L-seryl-[protein] <=> GDP + H(+) + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46625", "l": "a D-5-monosubstituted hydantoin => a L-5-monosubstituted hydantoin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15640", "l": "[alginate](n) + GDP-alpha-D-mannuronate <=> [alginate](n+1) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13072", "l": "ATP + ethanolamine <=> ADP + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018622", "l": "4-chlorophenylacetate 3,4-dioxygenase activity", "d": ["Catalysis of the reaction: 4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51110", "l": "10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813720", "l": "NCEH1 hydrolyzes cholesterol esters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23992", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA = 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.63", "l": "\"1-alkylglycerophosphocholine O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28706", "l": "Cu(2+)(in) <=> Cu(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76409", "l": "an L-alpha-amino acid + L-proline => H2O + Xaa-L-Pro dipeptide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110011", "l": "Binding of Grb10 to the insulin receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37555", "l": "D-kanosamine 6-phosphate + H2O = kanosamine + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.92", "l": "\"kanosamine-6-phosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211881", "l": "Coumarin is 7-hydroxylated by CYP2A13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811427", "l": "COPI vesicle uncoating at the ER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481007", "l": "Exocytosis of platelet alpha granule contents (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61402", "l": "ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysine => ATP + N(6)-(D-ribulosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014812", "l": "ROBOs bind keratan sulfate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73717", "l": "ATP(out) + dATP(in) => ATP(in) + dATP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45193", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051980", "l": "iron-nicotianamine transmembrane transporter activity", "d": ["Enables the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482546", "l": "2-acyl LPG is acylated to PG by CRLS1 (IM) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37150", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938228", "l": "RUNX1:CBFB:CREBBP binds the CSF2 (GM-CSF) gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.49", "l": "\"separase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.5", "l": "\"apyrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9824986", "l": "XPO1-dependent export of p-S69,S73 MITF-M (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050609", "l": "phosphonate dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + NAD+ + phosphonate = 2 H+ + NADH + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9749197", "l": "ORC1 binds to H4K20me2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23349", "l": "(R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) => (4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16391", "l": "CO2 + H2O + hydroquinone + NAD(+) => 4-hydroxybenzoate + 2 H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61366", "l": "ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate => ATP + dehydroepiandrosterone 3-sulfate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009536", "l": "DDX5 binds ESR1:estrogen:TFF1 gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45360", "l": "H2O + N-(11Z-eicosenoyl)-sphinganine = (11Z)-eicosenoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68916", "l": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807565", "l": "GNLY is transferred to the phagosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12748", "l": "a 1,4-lactone + H2O <=> a 4-hydroxyacid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067659", "l": "Assembly of hexameric IL-6 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68633", "l": "3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => 2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374337", "l": "Apelin receptor binds to apelin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417127", "l": "Elongation and translocation of the extended telomeric chromosome end (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32135", "l": "2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + propanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419351", "l": "PAF receptor binds platelet activating factor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10485", "l": "H2O + N-feruloylglycine => (E)-ferulate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676229", "l": "WIPIs bind PI3P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55723", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158860", "l": "SULT1A1 dimer sulfonates NHABP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35952", "l": "(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate => diphosphate + N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110307", "l": "REV1 binds AP-dsDNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32504", "l": "linalool + O2 + reduced [NADPH--hemoprotein reductase] => (6E)-8-hydroxylinalool + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31553", "l": "15-cis-4,4'-diapophytoene + diphosphate => presqualene diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32865", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19789", "l": "4-(dimethylamino)azobenzene + H2O + NADP(+) = 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.7.1.11", "l": "\"4-(dimethylamino)phenylazoxybenzene reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549322", "l": "OCT1 transports organic cations out of hepatic cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016217", "l": "N-ethylammeline chlorohydrolase activity", "d": ["Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38171", "l": "hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12970", "l": "a sn-glycero-3-phosphodiester + H2O => an alcohol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37485", "l": "1-dodecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-dodecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55208", "l": "(4R)-hydroxysphinganine 1-phosphate = (2R)-hydroxyhexadecanal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31922", "l": "indolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxyindolin-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29623", "l": "alpha-maltopentaose + beta-maltose = alpha-maltohexaose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362549", "l": "Hh-Np traffics to the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1793209", "l": "HYAL1 hydrolyses Chondroitin chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132085", "l": "Cleavage of C3 by surface-bound C3 convertases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9024726", "l": "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66059", "l": "indole-3-pyruvate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373741", "l": "SDK2 homophillic interaction (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-216723", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62320", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) = (+)-isomalbrancheamide B + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13172", "l": "maleate <=> fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637800", "l": "Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66921", "l": "6-deoxy-6-sulfo-D-fructose + D-erythrose 4-phosphate => (2S)-3-sulfolactaldehyde + D-sedoheptulose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018710", "l": "acetone carboxylase activity", "d": ["Catalysis of the reaction: acetone + ATP + CO2 + 2 H2O = acetoacetate + AMP + 4 H+ + 2 phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35675", "l": "H(+) + L-serine + tetradecanoyl-CoA = 3-oxohexadecasphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034632", "l": "retinol transmembrane transporter activity", "d": ["Enables the transfer of retinol from one side of a membrane to the other. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635424", "l": "Rv3364c binds cathepsin G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44937", "l": "(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192916", "l": "Initiation of vRNA Synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28288", "l": "a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69070", "l": "A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide => AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78783", "l": "luteolin + UDP-alpha-D-glucose = H(+) + isoorientin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38395", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = (9Z)-hexadecenoate + 1,3-di-(9Z)-hexadecenoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111956", "l": "Calmodulin activates Cam-PDE 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018766", "l": "RHOU binds effectors at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15517", "l": "H2O + N(2),6-disulfo-D-glucosamine = H(+) + N-sulfo-D-glucosamine + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.11", "l": "\"disulfoglucosamine-6-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102152", "l": "Delta12-linoleate epoxygenase activity", "d": ["Catalysis of the reaction: H+ + 1-palmitoyl-2-linoleoyl-phosphatidylcholine + NADPH + O2 = 1-palmitoyl-2-vernoloyl-phosphatidylcholine + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5653838", "l": "POLD,POLE binds deISGylated PCNA after TLS (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034710", "l": "inhibin complex binding", "d": ["Binding to an inhibin complex, a dimer of one inhibin-alpha subunit and one inhibin-beta subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29497", "l": "beta-eudesmol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70632", "l": "H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16920", "l": "2,6-dihydroxypyridine + H(+) + NADH + O2 <=> 2,3,6-trihydroxypyridine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603279", "l": "PIP3 recruits PDK1 and AKT to the membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43621", "l": "L-serine + NADP(+) => aminoacetaldehyde + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043728", "l": "2-keto-4-methylthiobutyrate aminotransferase activity", "d": ["Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33433", "l": "(3E)-2-oxohex-3-enedioate => (2Z,4E)-2-hydroxyhexa-2,4-dienedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68740", "l": "7-oxocholesterol + H(+) + NADPH = 7alpha-hydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45470", "l": "(Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15245", "l": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869590", "l": "The APOE gene transcription is stimulated by the complex of TFAP2A homodimer and DEK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24304", "l": "glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein]", "d": [], "t": []}, {"i": "EC:1.4.4.2", "l": "\"glycine dehydrogenase (aminomethyl-transferring)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15670", "l": "a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP => a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340124", "l": "CSN polymer binds CaPO4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830917", "l": "EYA1, PAX2, and HOX11 paralog bind the SIX2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177922", "l": "EGFR dimerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879221", "l": "PSTPIP1 binds Pyrin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66695", "l": "dTDP-beta-L-rhamnose + L-arginyl-[protein] <=> dTDP + H(+) + N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6807052", "l": "EBP isomerizes ZYMSTNL to LTHSOL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.3.4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013006", "l": "RHOA:GTP translocates to the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635859", "l": "GLI:SUFU dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77192", "l": "an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose => an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0042008", "l": "interleukin-18 receptor activity", "d": ["Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888589", "l": "Release of GABA at the synapse (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192434", "l": "Digestion of diacylglycerols by extracellular PTL:colipase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28087", "l": "2 H2O2 + Reactive Blue 5 => 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + 2 H(+) + 2 H2O + phthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796053", "l": "PRKCI phosphorylates NFE2L2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34496", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809764", "l": "SBF1 binds MTMR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-735702", "l": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77151", "l": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 4,5-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045551", "l": "cinnamyl-alcohol dehydrogenase activity", "d": ["Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+. Also acts on coniferyl alcohol, sinapyl alcohol and 4-coumaryl alcohol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610733", "l": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22221", "l": "ent-copalyl diphosphate => diphosphate + ent-kaur-16-ene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701488", "l": "Active ALK phosphorylates JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9681375", "l": "KIT binds ripretinib (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-606289", "l": "New CENPA-containing nucleosomes are deposited at the centromere (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69861", "l": "a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine => a uridine in 12S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603784", "l": "PEX19:class I PMP binds PEX3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380272", "l": "Plk1-mediated phosphorylation of Nlp (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983144", "l": "Transport of Antigen peptide in to ER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15072", "l": "3-devinyl-3-(1-hydroxyethyl)chlorophyllide a <=> chlorophyllide a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209108", "l": "Membrane-bound GISH binds to ARR receptor complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61515", "l": "malvidin + UDP-alpha-D-glucose <=> malvidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49873", "l": "(+)-dehydrodiconiferyl acid ketone + a quinone + H2O => (+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004906", "l": "type II interferon receptor activity", "d": ["Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047391", "l": "alkylglycerophosphoethanolamine phosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65051", "l": "4-acetoxybenzyl alcohol + NAD(+) <=> 4-acetoxybenzaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848005", "l": "ERBB2 promotes PTK6 autophosphorylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48296", "l": "H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64227", "l": "AH2 + O2 + uridine(34) in tRNA <=> 5-hydroxyuridine(34) in tRNA + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052610", "l": "beta-cryptoxanthin hydroxylase activity", "d": ["Catalysis of the reaction: beta-cryptoxanthin + a reduced electron acceptor + oxygen = zeaxanthin + an oxidized electron acceptor + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842667", "l": "CLIP1-LTK fusion autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-163215", "l": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55518", "l": "11-oxocucurbitadienol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxycucurbitadienol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9624112", "l": "CEBPA binds CDK4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51404", "l": "H2O + L-arginine + O2 = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.3.25", "l": "\"L-arginine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68677", "l": "3'-phosphoadenylyl sulfate + estrone 3-O-(beta-D-glucuronate) => adenosine 3',5'-bisphosphate + estrone 3-O-(3-sulfo-beta-D-glucuronate) + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65557", "l": "a globoside GalGb4Cer + H2O => an N-acyl-sphingoid base + beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48179", "l": "decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1602417", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[16] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3777129", "l": "HDAC3 containing complexes deacetylate histone (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71623", "l": "malonate(out) + phosphate(in) = malonate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.n10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433488", "l": "Phosphorylation of SHP2 by SFKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9865579", "l": "MT-CO1 and MT-CO2 complexes associate, installing heme moieties (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617067", "l": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250220", "l": "Homodimerization of ERBB4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672951", "l": "Inactive RAFs bind YWHAB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52252", "l": "a bacteriochlorophyllide c + H2O + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + a bacteriochlorophyllide e + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027302", "l": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39240", "l": "(2E)-triacontenoyl-CoA + H(+) + NADPH => NADP(+) + triacontanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2404134", "l": "RBP4:atROL binds TTR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30581", "l": "L-threonine + phosphate => H2O + O-phospho-L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24139", "l": "3'-phosphoadenylyl sulfate + a primary amine <=> a sulfamate + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78923", "l": "a short-chain (3S)-3-hydroxyacyl-CoA + NAD(+) = a short-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39038", "l": "an omega-hydroxy fatty acid + NAD(+) <=> an omega-oxo fatty acid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53098", "l": "4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine => 4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35468", "l": "(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033714", "l": "secondary-alcohol oxidase activity", "d": ["Catalysis of the reaction: secondary alcohol + O2 = H2O2 + ketone."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47507", "l": "chenodeoxycholate + NADP(+) <=> 3-oxochenodeoxycholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047852", "l": "diferric-transferrin reductase activity", "d": ["Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62496", "l": "ATP + H(+) + L-arginine = diphosphate + L-arginyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24779", "l": "H2O + pheophorbide a <=> C-13(2)-carboxypyropheophorbide a + methanol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15489", "l": "adenosine + H2O + 2 O2 = 9-riburonosyladenine + H(+) + 2 H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.39", "l": "\"nucleoside oxidase (H2O2-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66182", "l": "(4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside(out) + ADP + H(+) + phosphate => (4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114553", "l": "Activation of conventional Protein Kinase C (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183055", "l": "Binding of CBL to EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218830", "l": "SRC-1 phosphorylates PTK2-beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9667563", "l": "AVPR2 bind desmopressin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163296", "l": "Association of TFAM:mt promoter complex with POLRMT:TFB2M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9858647", "l": "HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781814", "l": "USP19 deubiquitinates RNF123 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66200", "l": "O2 + pentanoyl-CoA = (2E)-pentenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70970", "l": "3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) <=> 3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26152", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.78", "l": "\"6,7-dimethyl-8-ribityllumazine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50554", "l": "prostaglandin B1 => prostaglandin C1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701529", "l": "p-Y705, p-S727 STAT3 dimer translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.140", "l": "\"alternansucrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42531", "l": "uridine(955/2504/2580) in 23S rRNA <=> pseudouridine(955/2504/2580) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61195", "l": "(E)-4-coumaroyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + H(+) + myricetin 3-O-[(6-O-(E)-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39461", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+) => (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73497", "l": "an 8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => an 8-hydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5432814", "l": "SFTPA/SFTPD binds TLR2:TLR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73450", "l": "acetyl-CoA(in) + AMP(out) <=> acetyl-CoA(out) + AMP(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15782", "l": "L-tyrosine => 3-amino-3-(4-hydroxyphenyl)propanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839367", "l": "TGFBR3_mem cleavage by MMPs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5422942", "l": "RXRA:PPARD binds FABP5:atRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42119", "l": "5alpha-androstane-3alpha,17beta-diol + NADP(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33652", "l": "(9Z,12Z)-octadecadienoate + ATP + CoA => (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39984", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a 2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66655", "l": "(2E,6E)-farnesyl diphosphate <=> african-1-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54505", "l": "all-trans-hexaprenyl diphosphate => beta-hexaprene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21754", "l": "all-trans-capsorubin => all-trans-violaxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004637", "l": "phosphoribosylamine-glycine ligase activity", "d": ["Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25453", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + germacrene A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33425", "l": "diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein] => N(pros)-phospho-L-histidyl-[protein] + N,N'-diacetylchitobiose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9756156", "l": "UGT1A3 lactonizes ATV to ATVL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426355", "l": "NTN4 binds laminins with gamma-1, gamma-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660536", "l": "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68913", "l": "ATP + H(+) + NADPH + propanoate => AMP + diphosphate + NADP(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211968", "l": "CYP2W1 oxidises INDOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70702", "l": "H(+)(out) + K(+)(in) + L-glutamate(out) + 3 Na(+)(out) <=> H(+)(in) + K(+)(out) + L-glutamate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43176", "l": "cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.310", "l": "\"25S rRNA (cytosine(2870)-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-994137", "l": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.24", "l": "\"tubulin-glutamate carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299484", "l": "TIMM8:TIMM13 chaperones hydrophobic proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852552", "l": "MST1R autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168046", "l": "Collagen type XII degradation by MMP12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-606287", "l": "RSF complex binds the centromere (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804194", "l": "PRDM1 binds the TP53 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0016929", "l": "deSUMOylase activity", "d": ["An thiol-dependent isopeptidase activity that cleaves SUMO from a target protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825856", "l": "MITF-M-dependent MLANA gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.-", "l": "\"Carbon-sulfur lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008934", "l": "inositol monophosphate 1-phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954110", "l": "E2F6:TFDP1:EPC1 binds the PRC2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68709", "l": "(2E)-geranyl diphosphate + H2O => diphosphate + linalool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029468", "l": "Conversion of PA into DAG by PAP-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65098", "l": "a 1-hexadecanoyl-2-acylglycerol + CoA => a 2-acylglycerol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56148", "l": "hexadecanoyl-CoA + sn-glycerol 3-phosphocholine = CoA + hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190263", "l": "FGFR3b binds to FGF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71871", "l": "(S)-3-hydroxybutanoate(out) + H(+)(out) = (S)-3-hydroxybutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16315", "l": "5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+) => 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-425861", "l": "Activation of Protein Kinase C novel isoforms (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45064", "l": "H2O + N-hexadecanoylethanolamine = ethanolamine + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43003", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9844006", "l": "SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59047", "l": "dammarenediol-II + UDP-alpha-D-glucose <=> (20S)-20-O-(beta-D-glucosyl)-3-hydroxydammarene + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031723", "l": "CXCR4 chemokine receptor binding", "d": ["Binding to a CXCR4 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944706", "l": "miR-21 nonendonucleolytic RISC binds PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55545", "l": "L-lysyl-[citrate synthase] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41913", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADPH => hexadecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374214", "l": "Receptors CXCR4 and 7 bind CXCL12 ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868072", "l": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-213407", "l": "Disassociation of PLC-gamma1 from SLP-76 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22520", "l": "all-trans-retinal + H2O + O2 = all-trans-retinoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11740", "l": "2 glutathione + NADP(+) = glutathione disulfide + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.8.1.7", "l": "\"glutathione-disulfide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36026", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33253", "l": "6-kestotriose + beta-D-glucose => 2 sucrose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050267", "l": "rubber cis-polyprenylcistransferase activity", "d": ["Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78166", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174446", "l": "Removal of remaining Flap from the C-strand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36985", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA => (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61522", "l": "3-tyramine + A + H2O => AH2 + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67970", "l": "H(+) + phosphate + presqualene phosphate => H2O + presqualene diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77043", "l": "5-hydroxyoctan-4-amine + H2O + NAD(+) = 5-hydroxyoctan-4-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31178", "l": "(2E)-2-methylpropenoyl-CoA + H2O <=> (S)-3-hydroxyisobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19904", "l": "L-tryptophan + O2 <=> alpha,beta-didehydrotryptophan + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23523", "l": "acetyl-CoA + propanoate <=> acetate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043199", "l": "sulfate binding", "d": ["Binding to sulfate, SO4(2-), a negatively charged small molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42424", "l": "2-methylmaleate + H2O = (2R,3S)-3-methylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47087", "l": "4-methylsulfanyl-2-oxobutanoate + L-tyrosine <=> 3-(4-hydroxyphenyl)pyruvate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10408", "l": "4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-622420", "l": "NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008873", "l": "gluconate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052884", "l": "all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity", "d": ["Catalysis of the reaction: H2O + all-trans-retinyl palmitate = 11-cis-retinol + H+ + palmitate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010176", "l": "homogentisate phytyltransferase activity", "d": ["Catalysis of the reaction: homogentisate + phytyl diphosphate + H+ = 2-methyl-6-phytyl-1,4-benzoquinone + CO2 + diphosphate. 2-methyl-6-phytyl-1,4-benzoquinone is also known as 2-methyl-6-phytylplastoquinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158118", "l": "factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32014", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-T-muurolol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73165", "l": "FAD(in) + NAD(+)(out) => FAD(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645428", "l": "ALPK1 binds ADP-heptose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41544", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.306", "l": "\"8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)-tetracenomycin-C 3'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2485182", "l": "Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805276", "l": "CDK5 phosphorylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23694", "l": "H2O + maleate => (R)-malate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33476", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acylsphinganine => a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-(1D-myo-inositol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024881", "l": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18937", "l": "an N-acyl-L-homoserine lactone + H2O = a carboxylate + L-homoserine lactone", "d": [], "t": []}, {"i": "EC:3.5.1.97", "l": "\"acyl-homoserine-lactone acylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001003", "l": "RNA polymerase III type 2 promoter sequence-specific DNA binding", "d": ["Binding to a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51280", "l": "(13R)-hydroperoxy-(9Z,11E)-octadecadienoate = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32357", "l": "2 H(+) + ternatin C5 + 2 UDP => delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59322", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + H(+) => D-cellobiono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362525", "l": "CYP26A1,B1,C1 4-hydroxylate atRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390284", "l": "propionyl-CoA + carnitine => propionylcarnitine + CoASH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1604752", "l": "Initial activation of proMMP13 by MMP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9681616", "l": "AP2 binds chlorpromazine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65523", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008692", "l": "IL37(?-218) binds SMAD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030410", "l": "nicotianamine synthase activity", "d": ["Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H+ + nicotianamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033769", "l": "glyceollin synthase activity", "d": ["Catalysis of the reactions: 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin II or glyceollin III + NADP+ + 2 H2O, and 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin I + NADP+ + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694428", "l": "LMAN family proteins bind glycosylated cargo (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72660", "l": "NADPH + O2 + quinolin-8-ol => 8-hydroxyquinoline N-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35936", "l": "2 ATP + L-proline + L-tryptophan => 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53473", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35569", "l": "(9Z,12Z)-octadecadienoate + ethanolamine => H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39633", "l": "(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+) => (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3159259", "l": "MMAA:MUT binds AdoCbl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803892", "l": "SFN dimer binds BAX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40671", "l": "2-iminopropanoate + H2O = NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50093", "l": "a fatty acyl-CoA + taurine => an N-fatty acyl-taurine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-688136", "l": "TNFAIP3 (A20) deubiquitinates RIP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41832", "l": "(2E)-hexenoyl-[ACP] + H(+) + NADPH = hexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36492", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + H(+) + malonyl-CoA => (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428690", "l": "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0090433", "l": "palmitoyl-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + palmitic acid + CoA = AMP + diphosphate + palmitoyl-CoA."], "t": []}, {"i": "REACT:R-HSA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76416", "l": "Benzene is hydroxylated to phenol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67040", "l": "(3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+) = asnovolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22104", "l": "2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.80", "l": "\"nicotianamine aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102572", "l": "N-glutamylanilide hydrolase activity", "d": ["Catalysis of the reaction: N5-phenyl-L-glutamine + H2O = L-glutamate + aniline + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15169", "l": "H2O + N-succinyl-L-glutamate = L-glutamate + succinate", "d": [], "t": []}, {"i": "EC:3.5.1.96", "l": "\"succinylglutamate desuccinylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9846332", "l": "FUT1,2 transfer fucose to gangliosides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4224014", "l": "E-cadherin degradation by ADAM10, ADAM15 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641205", "l": "RSPO:LGR binds ZNRF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430347", "l": "MigFilin associates with Filamin and F-actin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60240", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45987", "l": "3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochola-1,4-dien-22-oyl-CoA + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048001", "l": "erythrose-4-phosphate dehydrogenase activity", "d": ["Catalysis of the reaction: D-erythrose 4-phosphate + H2O + NAD+ = 4-phospho-D-erythronate + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53399", "l": "a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] <=> 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008967", "l": "phosphoglycolate phosphatase activity", "d": ["Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016498", "l": "neuromedin K receptor activity", "d": ["Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24861", "l": "pelargonidin 3-O-rutinoside + UDP-alpha-D-glucose = H(+) + pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218822", "l": "CRK binds BCAR1 and or PXN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56166", "l": "(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA => (9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22231", "l": "H(+) + NADH + presqualene diphosphate <=> diphosphate + NAD(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60069", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H(+) + 3 NADH + 3 O2 => 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 4 H2O + 3 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51243", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-430190", "l": "p-SLP-76 binds NCK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20031", "l": "H(+) + NADPH + vellosimine => 10-deoxysarpagine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49429", "l": "CTP + phosphonoformate => CMP-5'-phosphonoformate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69412", "l": "2 glutathione + tert-butyl hydroperoxide = glutathione disulfide + H2O + tert-butanol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418553", "l": "cAMP degradation by Phosphodiesterases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944262", "l": "Association of procollagen type X (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982768", "l": "GH:GHR:JAK2 complex undergoes a conformational change (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213207", "l": "Formation of collagen networks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9858590", "l": "DLST transfers glutaryl to CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19881", "l": "GTP + L-lysyl-[protein] = diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77768", "l": "11-cis-retinol + a fatty acyl-CoA => 11-cis-retinyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660694", "l": "Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686072", "l": "p-3Y-SHC1 dissociates from IGF1R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48979", "l": "5-methyl-phenazine-1-carboxylate + 2 H(+) + NADH + O2 <=> CO2 + H2O + NAD(+) + pyocyanin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59600", "l": "5-methoxytryptamine + H2O + O2 = 5-methoxyindoleacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70975", "l": "CS acetylates OA to citrate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047641", "l": "aldose-6-phosphate reductase (NADPH) activity", "d": ["Catalysis of the reaction: D-glucitol 6-phosphate + NADP+ = D-glucose 6-phosphate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5617143", "l": "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29591", "l": "2-hydroxyethane-1-sulfonate + NADP(+) = H(+) + NADPH + sulfoacetaldehyde", "d": [], "t": []}, {"i": "EC:1.1.1.313", "l": "\"sulfoacetaldehyde reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45518", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(155)-[phycoerythrocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78349", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20752", "l": "A + 2 cob(II)alamin + 2 H(+) + 2 H2O = AH2 + 2 aquacob(III)alamin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2247510", "l": "MARCO:ligand is endocytosed (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43834", "l": "3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate => 5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42313", "l": "H(+) + NADP(+) + 2 reduced [adrenodoxin] => NADPH + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43273", "l": "a ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine => a ganglioside GD2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71911", "l": "cholate(out) + 2 Na(+)(out) = cholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12140", "l": "a 2'-deoxyribonucleoside + ATP = a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684140", "l": "ATM phosphorylates RBBP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72427", "l": "chloride(in) + K(+)(in) = chloride(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4755411", "l": "PIAS4 SUMOylates IKBKG with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72134", "l": "agmatine(out) <=> agmatine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41527", "l": "5 H(+) + 5 malonyl-CoA <=> 5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32349", "l": "3',5'-di-O-methyltricetin + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + tricetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9615901", "l": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39277", "l": "(15Z)-tetracosenoyl-CoA + NADP(+) => (2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62205", "l": "1-propanol + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25473", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-himachalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19620", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198756", "l": "ERK1/2 phosphorylates MSK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114252", "l": "Cleavage of Procaspase-3 by the apoptosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32473", "l": "(7S)-marmesin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => demethylsuberosin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65958", "l": "ADP + estrone 3-sulfate(in) + H(+) + phosphate => ATP + estrone 3-sulfate(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75556", "l": "(-)-cyatha-3,12-diene + O2 + reduced [NADPH--hemoprotein reductase] => erinacol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67764", "l": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26067", "l": "ATP + hygromycin B <=> 4-O-phosphohygromycin B + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56183", "l": "8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate <=> 2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-622310", "l": "Activated NOD1 oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57312", "l": "H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine = cytidine 5'-diphosphoramidate + H(+) + L-glutamate", "d": [], "t": []}, {"i": "EC:3.5.1.129", "l": "\"N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007686", "l": "RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961907", "l": "E2F1 binds the CDC45 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44807", "l": "1,4-dihydroxy-2-naphthoate + all-trans-nonaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-9 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004141", "l": "dethiobiotin synthase activity", "d": ["Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO2 = ADP + dethiobiotin + 4 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61454", "l": "11a-hydroxy-oxytetracycline + H2O + NADP(+) => H(+) + NADPH + O2 + oxytetracycline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938431", "l": "BTN3A1 and BTN1A1 binds periplakin (PPL) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-176175", "l": "Stalling of DNA replication fork and RPA binding (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42827", "l": "2 H(+) + 2 NADH + 2 O2 + tetracenomycin A2 <=> H2O + 2 NAD(+) + tetracenomycin C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018758", "l": "2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity", "d": ["Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031866", "l": "EP3 subtype prostaglandin E2 receptor binding", "d": ["Binding to an EP3 subtype prostaglandin E2 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40053", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O => chorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74556", "l": "(S)-malate(out) => (S)-malate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678749", "l": "Defective ABCB4 does not transport PC from plasma membrane to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22466", "l": "2 H(+) + H2O + N-hydroxy-L-tyrosine + oxidized [NADPH--hemoprotein reductase] => L-tyrosine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44104", "l": "decanal + H2O + NAD(+) = decanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36144", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADPH => hexadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49106", "l": "5'-deoxyadenosine + H(+) + L-methionine + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester => Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052811", "l": "1-phosphatidylinositol-3-phosphate 4-kinase activity", "d": ["Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987014", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69252", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate = 2-(thiiran-2-yl)acetonitrile + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080077", "l": "trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a trihydroxyferuloyl spermidine molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792572", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9701064", "l": "TRPV1 binds TRPV1 agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683735", "l": "CHEK2 is recruited to DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.8", "l": "\"Delta(3)-Delta(2)-enoyl-CoA isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052748", "l": "baicalin beta-D-glucuronidase activity", "d": ["Catalysis of the reaction: baicalin + H2O = baicalein + D-glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52729", "l": "3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate => a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46060", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8856951", "l": "PP2A demethylation by PPME1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466831", "l": "A2PE hydrolyses to A2E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42405", "l": "H2O + lactose 6-phosphate => beta-D-glucose + D-galactose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683831", "l": "CCDC59 binds TTF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32260", "l": "beta-D-fructose 1-phosphate + methylglyoxal => 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351936", "l": "Caspase-mediated cleavage of claspin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645414", "l": "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948757", "l": "AKT phosphorylates MKRN1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871227", "l": "RET binds GFRA4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210304", "l": "Interaction of integrin alphaVbeta3 with PECAM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.6", "l": "\"ribonuclease IV\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13407", "l": "CoA + H(+) + N-(4-guanidinobutyl)-4-hydroxycinnamamide => 4-coumaroyl-CoA + agmatine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34821", "l": "curcumin + H(+) + NADPH => dihydrocurcumin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35402", "l": "1-O-(trans-4-coumaroyl)-beta-D-glucose + cyanidin 3-O-(6-O-glucosyl-2-O-xylosylgalactoside) betaine <=> beta-D-glucose + cyanidin 3-O-[6-O-(6-O-4-hydroxycinnamoyl-beta-D-glucosyl)-2-O-beta-D-xylosyl-beta-D-galactoside] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9734547", "l": "JAK2-activated MAPKs phosphorylate YBX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46106", "l": "corticosterone + H2O + 2 oxidized [adrenodoxin] => 21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034002", "l": "(R)-limonene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (4R)-limonene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682863", "l": "RNF168 binds DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696491", "l": "CNTF binds CNTFR complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48621", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30062", "l": "(S)-dihydroorotate + fumarate <=> orotate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69906", "l": "cytidine(out) + 2 Na(+)(out) <=> cytidine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070290", "l": "N-acylphosphatidylethanolamine-specific phospholipase D activity", "d": ["Catalysis of the reaction: H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine (NAPE) = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine (NAE) + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110351", "l": "Displacement of SMUG1 glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034934", "l": "phenanthrene-4-carboxylate dioxygenase activity", "d": ["Catalysis of the reaction: phenanthrene-4-carboxylate + 2 H+ + 2 e- + O2 = cis-3,4-phenanthrenedihydrodiol-4-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980044", "l": "NOTCH1 binds JAG2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193713", "l": "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9706399", "l": "RHOBTB3 hydrolyzes ATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74348", "l": "O-acyl-(R)-carnitine(in) => O-acyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.354970481220079", "identifiers": [{"i": "GO:0008066", "l": "glutamate receptor activity", "d": ["Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783177", "l": "USP21 deubiquitinates GATA3,IL33 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987214", "l": "p-STAT3 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28828", "l": "L-ornithine(out) + putrescine(in) => L-ornithine(in) + putrescine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30835", "l": "H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = NADP(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32229", "l": "(6S)-NADPHX => (6R)-NADPHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.1.3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047144", "l": "2-acylglycerol-3-phosphate O-acyltransferase activity", "d": ["Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084910", "l": "Collagen type II binds integrin alpha2beta1, alpha1beta1, alpha11beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-435244", "l": "PECAM1 is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59908", "l": "H2O + hexanal + NADP(+) = 2 H(+) + hexanoate + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18118", "l": "L-tyrosine + O2 => H2O + L-dopaquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11335", "l": "ATP + RNA(n) <=> diphosphate + RNA(n)-3'-adenine ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638004", "l": "RP2 binds ARL3:GTP:UNC119B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36479", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + H(+) + malonyl-CoA = (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16462", "l": "ATP + H2O + urate(in) => ADP + H(+) + phosphate + urate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29953", "l": "H(+)(out) + uridine(out) => H(+)(in) + uridine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65851", "l": "A + a 3-oxo-Delta(1)-steroid + H2O <=> a steroid 1,3-dione + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60097", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) => 3-dehydro-4alpha-methylzymosterol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74666", "l": "acetylcholine(in) <=> acetylcholine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33709", "l": "ADP + H(+) + O-phospho-L-threonine => ATP + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836955", "l": "NS2 (1B) binds to MAP1B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28143", "l": "H2O + streptothricin D => streptothricin D acid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13693", "l": "(6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)", "d": [], "t": []}, {"i": "EC:2.1.1.19", "l": "\"trimethylsulfonium--tetrahydrofolate N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47771", "l": "guanosine(2270) in 21S rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2270) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12883", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+) => ADP-alpha-D-glucose + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090430", "l": "caffeoyl-CoA: alcohol caffeoyl transferase activity", "d": ["Catalysis of the reaction: caffeoyl-CoA + a saturated primary alcohol = an alkyl caffeate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4570499", "l": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20986", "l": "an N-acylsphing-4-enine 1-phosphate + choline + H(+) => a sphingomyelin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047509", "l": "(R)-dehydropantoate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-4-dehydropantoate + H2O + NAD+ = (R)-3,3-dimethylmalate + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102311", "l": "8-hydroxygeraniol dehydrogenase activity", "d": ["Catalysis of the reaction: (6E)-8-hydroxygeraniol + 2 NADP = (6E)-8-oxogeranial + 2 NADPH + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835454", "l": "DNAJC3 binds PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654692", "l": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20240", "l": "(1S,4S)-5-oxo-1,2-campholide <=> [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663245", "l": "NR1D1 (REV-ERBA) binds heme, the NPAS2 gene, and recruits corepressors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4755524", "l": "SUMOylation of NR1I2 with SUMO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67086", "l": "ADP + H(+) + hexacosanoate(out) + phosphate => ATP + H2O + hexacosanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75016", "l": "Association of p-S216-CDC25C with 14-3-3 proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5689544", "l": "UCHL5 binds INO80 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187332", "l": "Cytosolic CMs translocate to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37480", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5638333", "l": "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51566", "l": "(25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24626", "l": "AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr) => ATP + L-threonine + tRNA(Thr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171106", "l": "LDLR:LDL complex => LDLR + LDL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666001", "l": "Profilin:G-actin binds MKL1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19643", "l": "(E)-4-coumaroyl-CoA + AMP + diphosphate => (E)-4-coumarate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785895", "l": "Expression of IL4, IL13-upregulated extracellular proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947673", "l": "Melanin-concentrating hormone receptors bind MCH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.12", "l": "\"peptidyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030767", "l": "3-hydroxyanthranilate 4-C-methyltransferase activity", "d": ["Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10331", "l": "an L-glycol + NAD(+) <=> a 2-hydroxycarbonyl + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9824994", "l": "RPS6KA1-dependent phosphorylation of MITF-M (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265177", "l": "Exocyst complex formation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676160", "l": "AAMP binds NOD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2197691", "l": "WIP binds WASP,N-WASP, activating them (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48575", "l": "3,5-dichlorocatechol + O2 <=> (2E,4E)-2,4-dichloromuconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40182", "l": "decanoyl-CoA + O2 <=> (2E)-decenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44869", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol => 1,2-diacyl-sn-glycero-3-phosphoethanol + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047810", "l": "D-alanine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69323", "l": "glucoerucin + H2O <=> (Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9692880", "l": "HRH3 binds Hist (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951500", "l": "Dissociation of CANX from nonameric complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417842", "l": "P2Y10 receptor can bind to LPA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44555", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O <=> H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29481", "l": "(+)-epicubenol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54050", "l": "4-epi-cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24255", "l": "H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate <=> 2 ADP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67065", "l": "AH2 + asnovolin K => A + asnovolin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47089", "l": "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) => 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70156", "l": "6alpha-hydroxy-28-norcastasterone + O2 + reduced [NADPH--hemoprotein reductase] => 28-norcastasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390438", "l": "FAR2 reduces PalmCoA to HXOL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.7.-.-", "l": "\"Carbon-phosphorus lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53062", "l": "estrone 4-O-(beta-D-glucuronate) + H(+) + UDP => 4-hydroxyestrone + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177694", "l": "Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35994", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24909", "l": "L-tyrosine <=> (E)-4-coumarate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68343", "l": "(R)-4'-phospho-S-sulfopantetheine + H2O <=> (R)-S-sulfopantetheine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12102", "l": "H2O + microthecin => 1,5-anhydro-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018720", "l": "phenol kinase activity", "d": ["Catalysis of the reaction: phenol + X-phosphate = XH + phenylphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937844", "l": "SRC,YES1 phosphorylate YAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78013", "l": "a 1,3-diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine => a 1,3-diacyl-2-(9Z,12Z-octadecadienoyl)-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-517444", "l": "TAT aminates HPP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-947538", "l": "Transfer of sulfur from MOCS3-S-S onto MOCS2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63123", "l": "(11Z)-eicosenamide + H2O <=> (11Z)-eicosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57135", "l": "L-ascorbate + O2 + tyramine <=> (R)-octopamine + H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75190", "l": "2,5-dihydroxybenzoyl-CoA + H2O <=> 2,5-dihydroxybenzoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029452", "l": "Recruitment of SYK to phosphorylated ITAMs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42636", "l": "AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin", "d": [], "t": []}, {"i": "EC:2.8.1.9", "l": "\"molybdenum cofactor sulfurtransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-706479", "l": "TAK1 is activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140686", "l": "factor Va + factor Xa -> Va:Xa complex (prothrombinase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78103", "l": "an acyl-CoA + sn-glycerol 3-phosphocholine = a 2-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202164", "l": "Translocation of PDK1 to Plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686483", "l": "Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165777", "l": "Phosphorylation and activation of eIF4B by activated S6K1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64727", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140344", "l": "triglyceride transfer activity", "d": ["Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175108", "l": "Target DNA binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987007", "l": "p-STAT1 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22759", "l": "a long-chain primary fatty alcohol + O2 <=> a long-chain fatty aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49109", "l": "Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + S-adenosyl-L-methionine => 3,8-divinyl protochlorophyllide a + 5'-deoxyadenosine + 2 H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983156", "l": "Polyubiquitination of substrate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428690", "l": "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73871", "l": "(R)-noradrenaline(out) = (R)-noradrenaline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0030552", "l": "cAMP binding", "d": ["Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2272668", "l": "Interaction of DAP12 and KIR2DS5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73189", "l": "(2R,3S,11R)-aszonalenin + diphosphate => (R)-benzodiazepinedione + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77639", "l": "3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77364", "l": "2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine => 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46781", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9032073", "l": "NTRK2-phosphorylated FRS2 binds GRB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047312", "l": "L-phenylalanine:pyruvate aminotransferase activity", "d": ["Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005026", "l": "transforming growth factor beta receptor activity, type II", "d": ["Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor."], "t": []}, {"i": "REACT:R-HSA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58343", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O <=> chenodeoxycholate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31791", "l": "H2O + tuberculosinyl diphosphate = (13S)-edaxadiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003919", "l": "FMN adenylyltransferase activity", "d": ["Catalysis of the reaction: ATP + FMN = diphosphate + FAD."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70940", "l": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.57", "l": "\"AMP phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161662", "l": "PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64844", "l": "(2E)-geraniol + benzoyl-CoA = (2E)-geranyl benzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052381", "l": "tRNA dimethylallyltransferase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034840", "l": "3-hydroxymenthone dehydrogenase activity", "d": ["Catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19278", "l": "ATP + L-pyrrolysine + tRNA(Pyl) => AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70565", "l": "2''-O-hexadecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047081", "l": "3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NADP+ + 2-(acetamidomethylene)succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29480", "l": "(2E,6E)-farnesyl diphosphate + H2O => (+)-epicubenol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199404", "l": "CD40L binds CD40 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40961", "l": "1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 2 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40559", "l": "dTDP-beta-L-evernosamine + NADPH + O2 = dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862084", "l": "PILRA,PILRB bind CD99 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35276", "l": "3-hydroxyoctadecanoyl-CoA + NAD(+) => 3-oxooctadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022874", "l": "protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19361", "l": "(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.10", "l": "\"(2E,6E)-farnesyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5220959", "l": "TDG excises 5-formylcytosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56957", "l": "ITP + pyruvate => H(+) + IDP + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837376", "l": "RSV G binds CD209,CLEC4M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60118", "l": "CO2 + hydroxymethylphosphonate + succinate => 2-oxoglutarate + methylphosphonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031522", "l": "NR1H2,3 binds the APOE gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74718", "l": "Internalisation of the insulin receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31485", "l": "H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP => soyasapogenol E + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103080", "l": "methylthiopropylmalate isomerase activity", "d": ["Catalysis of the reaction: 2-(3-methylthiopropyl)malate(2-) = 3-(3'-methylthio)propylmalate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52858", "l": "(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + sarcosine => (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + H(+) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1470010", "l": "Dimerization of STATs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090565", "l": "protein-phosphocysteine-mannitol phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannitol(out) = protein cysteine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9710263", "l": "GZMB cleaves GSDME (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34659", "l": "C30 botryococcene + S-adenosyl-L-methionine = 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61946", "l": "24-methylene cholesteryl beta-D-glucoside + H(+) + UDP => 24-methylenecholesterol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30096", "l": "(S)-malate + a menaquinone => a menaquinol + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10416", "l": "fumarate + toluene = 2-benzylsuccinate", "d": [], "t": []}, {"i": "EC:4.1.99.11", "l": "\"benzylsuccinate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005124", "l": "scavenger receptor binding", "d": ["Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768832", "l": "SRF binds NPAS4 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193755", "l": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13144", "l": "2-methylpropanoyl-CoA <=> butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56170", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5625738", "l": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842660", "l": "LTK binds ALKAL ligand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428690", "l": "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791084", "l": "Expression of SYVN1 (HRD1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804942", "l": "MDM2 homodimers auto-ubiquitinate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21672", "l": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.100", "l": "\"protein-S-isoprenylcysteine O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64077", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 => 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888589", "l": "Release of GABA at the synapse (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52005", "l": "H2O + methylglyoxal + NAD(+) => 2 H(+) + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2465971", "l": "RLBP1 binds atROL to form RLBP1:atROL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-379426", "l": "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651942", "l": "Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008811", "l": "chloramphenicol O-acetyltransferase activity", "d": ["Catalysis of the reaction: chloramphenicol + acetyl-CoA = chloramphenicol 3-acetate + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44670", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+) => 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62340", "l": "(+)-premalbrancheamide + bromide + FAD + 2 H(+) = (+)-malbrancheamide C + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14875", "l": "H(+) + indole-3-acetaldehyde + NADH => indole-3-ethanol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67009", "l": "a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66815", "l": "5-aminopentanoate + acetyl-CoA + 20 H(+) + 8 malonyl-CoA + 13 NADPH <=> 8 CO2 + 9 CoA + 7 H2O + 13 NADP(+) + wortmanamide B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442832", "l": "PAK phosphorylates cortactin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57530", "l": "a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+) => a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44572", "l": "4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) = 2-all-trans-heptaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-430347", "l": "MigFilin associates with Filamin and F-actin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59182", "l": "2 AMP + H(+) => 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38997", "l": "a 1-acyl-sn-glycero-3-phosphate + choline + H(+) => a 1-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76299", "l": "L-aspartate(in) + L-cystine(out) = L-aspartate(out) + L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48724", "l": "aurachin B + H(+) + H2O = 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047120", "l": "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity", "d": ["Catalysis of the reaction: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964759", "l": "Alternative endo-mannosidase I route (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450133", "l": "IL1R1:IL1:IL1RAP binds MYD88 homodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72382", "l": "chloride(out) + iodide(in) <=> chloride(in) + iodide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28003", "l": "beta-D-fructose 6-phosphate => D-glyceraldehyde 3-phosphate + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019808", "l": "polyamine binding", "d": ["Binding to a polyamine, an organic compound containing two or more amino groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9615348", "l": "AGT(34-41) binds to AGTR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449855", "l": "IL10 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070205", "l": "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity", "d": ["Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60306", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32942", "l": "a 1,2-diacyl-sn-glycerol + CDP-choline <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023451", "l": "FGFR1c P252X mutants bind ligand with enhanced affinity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63091", "l": "a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine <=> a 2'-O-methylribonucleotide in U6 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2090079", "l": "GLB1 hydrolyses linker chain(2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57570", "l": "7-deoxyloganetic aldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganetic alcohol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30329", "l": "all-trans-zeaxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => beta-cryptoxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10186", "l": "3-oxoadipate + H(+) => (4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379048", "l": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693061", "l": "STAMBP binds STAM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51443", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72103", "l": "Formation of pre-mRNPs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73229", "l": "(3R)-citramalate(out) + sulfate(in) => (3R)-citramalate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48820", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12452", "l": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.134", "l": "\"inositol-tetrakisphosphate 1-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77217", "l": "2-deoxyribose 5-triphosphate + adenine => dATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9794444", "l": "ALB binds Cipro (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71587", "l": "(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31159", "l": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78449", "l": "a fatty acid + a lysoGb3(d18:1(4E)) => a globoside Gb3Cer (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110224", "l": "Cleavage of thymine glycol by NTHL1 glycosylase   (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615987", "l": "RANBP2 SUMOylates HDAC4 with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9695890", "l": "SPNS2,MFSD2B transport S1P from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28822", "l": "5-dehydro-D-gluconate(in) + H(+)(in) <=> 5-dehydro-D-gluconate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54206", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015412", "l": "ABC-type molybdate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2990882", "l": "CDK1 phosphorylates NUP98 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34401", "l": "9-cis-10'-apo-beta-carotenal + beta-ionone => 9-cis-beta-carotene + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42266", "l": "3-oxodecanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099609", "l": "microtubule lateral binding", "d": ["Binding to the side of a microtubule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60958", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + H(+) + UDP => 17-hydroxy-(9Z)-octadecenoate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395517", "l": "NADPH transfers electrons to FDXR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35146", "l": "benzoyl-CoA + 2 H(+) + 3 malonyl-CoA <=> 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.5", "l": "\"dipeptidyl-peptidase IV\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784598", "l": "NPPA(124-151) binds NPR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76473", "l": "A + cob(I)alamin + 2 H(+) => AH2 + cob(III)alamin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110375", "l": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44128", "l": "(9E)-octadecenoyl-CoA + hexadecan-1-ol = CoA + hexadecanyl (9E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029268", "l": "Phosphorylation and activation of PLCG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875431", "l": "LRIG1 undergoes ubiquitination (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31894", "l": "2-hydroxy-1-phenyl-1-propanone + NADP(+) <=> 1-phenyl-1,2-propanedione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102446", "l": "rhamnetin 3-O-methyltransferase activity", "d": ["Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193727", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48118", "l": "H(+) + N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => L-arginyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467665", "l": "AGRN binds Beta amyloid fibril via GAG chains (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69106", "l": "H2O + kynurenate + L-cysteine => 2-oxo-3-sulfanylpropanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446694", "l": "IRAK4 phosphorylates IRAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15244", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate <=> 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237160", "l": "MTA is cleaved and phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033432", "l": "CGG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CGG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11059", "l": "4-aminobenzoate + 2 H(+) + NADPH + O2 <=> 4-aminophenol + CO2 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69869", "l": "a 5-methyluridine in RNA + H(+) + S-adenosyl-L-homocysteine => a uridine in RNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47406", "l": "3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH => (24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35792", "l": "2'-deamino-2'-hydroxyparomamine + UDP-alpha-D-kanosamine => H(+) + kanamycin X + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052830", "l": "inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate."], "t": []}, {"i": "REACT:R-HSA-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12388", "l": "formononetin + O2 + reduced [NADPH--hemoprotein reductase] = 2'-hydroxyformononetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51580", "l": "a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out) = a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78498", "l": "acetyl-CoA + CMP-5'-(N-hydroxy-3-aminopropyl)phosphonate <=> CMP-5'-(N-acetyl-N-hydroxy-3-aminopropyl)phosphonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45315", "l": "NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10509", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28855", "l": "H(+)(in) + melibiose(in) = H(+)(out) + melibiose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73533", "l": "CTP(in) + UTP(out) => CTP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047657", "l": "alpha-1,3-glucan synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691154", "l": "HFE binds TFRC dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50607", "l": "acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45753", "l": "(3E)-decenoyl-CoA => (2E)-decenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047092", "l": "27-hydroxycholesterol 7-alpha-monooxygenase activity", "d": ["Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080078", "l": "tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a tricaffeoyl spermidine molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69548", "l": "H(+) + O-phospho-L-serine = CO2 + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45043", "l": "2 Fe(III)-[cytochrome c] + hydroxylamine <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.102", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69299", "l": "CDT1 binds geminin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16485", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate = 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.8", "l": "\"imidazoleacetate--phosphoribosyldiphosphate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69755", "l": "(2-aminobenzyl)malonyl-CoA + H(+) + O2 = (E)-2-aminocinnamoyl-CoA + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12868", "l": "1-methyladenosine + H2O <=> 1-methyladenine + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12349", "l": "(S)-muconolactone => (4,5-dihydro-5-oxofuran-2-yl)-acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821410", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6791109", "l": "GADD45A binds PCNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-549112", "l": "G3P is acylated to 1-acyl LPA by AGPAT6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390674", "l": "ADRB1 bind ADR,NAd (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9718360", "l": "GNRHR binds GNRHR peptide agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50159", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190065", "l": "Activated TrkA receptor internalizes to endosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72455", "l": "fumarate(out) + 3 H(+)(out) = fumarate(in) + 3 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34058", "l": "festuclavine + NAD(+) <=> 6,8-dimethyl-6,7-didehydroergoline + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34822", "l": "dihydrocurcumin + NADP(+) <=> curcumin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25271", "l": "(R)-adrenaline + H(+) + S-adenosyl-L-homocysteine => (R)-noradrenaline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635861", "l": "NUMB:ITCH binds GLI1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419644", "l": "Transphosphorylation of pLIMK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40156", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35976", "l": "2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 => A + CO2 + H2O + succinate + verruculogen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63262", "l": "4-pyridoxate + NAD(+) => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69173", "l": "Joining of adjacent Okazaki fragments (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74008", "l": "dimethylallyl diphosphate + H2O + yaequinolone E => [(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57629", "l": "3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate => H2O + ML-236C carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46240", "l": "a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64538", "l": "a 1,2-diacyl-sn-glycerol + a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-688137", "l": "RIP2 is K63 polyubiquitinated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617462", "l": "HOXD1 gene is transcribed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008531", "l": "riboflavin kinase activity", "d": ["Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63657", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine => 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74991", "l": "deoxyerythrostominone(in) = deoxyerythrostominone(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51178", "l": "5-methylcytidine(48) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine => cytidine(48) in tRNA(Asp) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21841", "l": "N(6),N(6)-dimethyl-L-lysyl-[histone] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12982", "l": "H2O + O2 + S-sulfanylglutathione => glutathione + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0160008", "l": "protein decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]."], "t": []}, {"i": "RHEA:69172", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25676", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35096", "l": "choline => acetaldehyde + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41422", "l": "CO2 + grixazone B + 4 H2O => 2 3-amino-4-hydroxybenzoate + H(+) + N-acetyl-L-cysteine + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54088", "l": "3,4-dihydroxyphenylacetate + H(+) + NADH + O2 = 2,4,5-trihydroxyphenylacetate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033449", "l": "GUU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GUU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429441", "l": "SYK activation by SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0004731", "l": "purine-nucleoside phosphorylase activity", "d": ["Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2213192", "l": "Hemidesmosome formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10851", "l": "an [alpha-factor](in) + ATP + H2O <=> ADP + an [alpha-factor](out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18468", "l": "L-dopa + O2 <=> 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102203", "l": "brassicasterol glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + brassicasterol = UDP(3-) + 3-O-beta-D-glucosyl-brassicasterol + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54438", "l": "a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate => 2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37320", "l": "ATP + glycyl-L-methionine(out) + H2O => ADP + glycyl-L-methionine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223313", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15713", "l": "a beta-D-galactoside + acetyl-CoA = a 6-acetyl-beta-D-galactoside + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.18", "l": "\"galactoside O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42522", "l": "pseudouridine(2605) in 23S rRNA => uridine(2605) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158145", "l": "factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75690", "l": "ATP(in) <=> ATP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69654", "l": "cumene hydroperoxide + 2 glutathione <=> 2-phenylpropan-2-ol + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905108", "l": "guanosine binding", "d": ["Binding to guanosine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57314", "l": "cytidine 5'-diphosphoramidate + H(+) + L-glutamate => H2O + N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110475", "l": "DAkt1-mediated phosphorylation inactivates DFOXO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44830", "l": "CoA + O-decanoyl-(R)-carnitine => (R)-carnitine + decanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814555", "l": "Integrator complex processes the 3' end of snRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67250", "l": "(E)-4-hydroxynon-2-enoate + 2 H(+) + NADH => (E)-4-hydroxynon-2-enal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49615", "l": "(R)-2-hydroxyglutarate + NAD(+) <=> 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55782", "l": "all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP => all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032405", "l": "MutLalpha complex binding", "d": ["Binding to a MutLalpha mismatch repair complex."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216069", "l": "Interaction of integrin alphaDbeta2 with fibrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36358", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74069", "l": "ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+) => ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13625", "l": "A + H2O + N(6)-dimethylallyladenine = 3-methyl-2-butenal + adenine + AH2", "d": [], "t": []}, {"i": "EC:1.5.99.12", "l": "\"cytokinin dehydrogenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362549", "l": "Hh-Np traffics to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74647", "l": "GTP + N-acetyl-D-glucosamine = GDP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483116", "l": "GPCho is hydrolyzed to Cho and G3P by GPCPD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.16", "l": "\"steroid 21-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452894", "l": "Expression of SOX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5618331", "l": "HDAC6 deacetylates microtubules (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74477", "l": "(-)-4'-methoxycyclopenine + CO2 + succinate => (Z)-4'-methoxydehydrocyclopeptine + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64463", "l": "acetyl phosphate + L-lysyl-[protein] <=> H(+) + N(6)-acetyl-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814671", "l": "Fusion of late-endosome derived vesicles at the TGN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-141437", "l": "Formation of the MCC complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39163", "l": "3-oxohexadecanoyl-CoA + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22783", "l": "(9Z,12Z)-octadecadienoate + O2 <=> (13S)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51232", "l": "2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75793", "l": "(S)-lactate(in) + Na(+)(in) => (S)-lactate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.70", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-417843", "l": "P2Y13 binds ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.13.1", "l": "\"exoribonuclease II\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59062", "l": "(20S)-ginsenoside Rh2 + D-glucose => (20S)-ginsenoside Rg3 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34560", "l": "1-deoxy-11beta-hydroxypentalenate + NAD(+) => 1-deoxy-11-oxopentalenate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73348", "l": "beta-alanyl-[peptidyl-carrier protein] + tryptamine => beta-alanyl-tryptamine + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371591", "l": "Trimerization of cytosolic HSF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41940", "l": "[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate = [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.43", "l": "\"[amino-group carrier protein]--L-2-aminoadipate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.15", "l": "\"DNA-deoxyinosine glycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15390", "l": "ATP => 3',5'-cyclic AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788556", "l": "NUBPL transfers 4Fe-4S to NDUFV1, V2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389862", "l": "Conversion of glyoxylate to oxalate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14333", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol = 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}, {"i": "EC:4.6.1.14", "l": "\"glycosylphosphatidylinositol diacylglycerol-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51106", "l": "13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74247", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28577", "l": "H(+)(in) + sulfate(in) <=> H(+)(out) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39059", "l": "26-hydroxyhexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 26-oxohexacosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58904", "l": "8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH = C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36606", "l": "2-oxoglutarate + L-enduracididine + O2 <=> (3S)-3-hydroxy-L-enduracididine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.11", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14510", "l": "2-oxoglutarate + mugineate + O2 => 3-epihydroxymugineate + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77292", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol => 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28809", "l": "L-cysteinylglycine + L-glutamate => glutathione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14776", "l": "2 NADPH + palmatine + S-adenosyl-L-methionine <=> corydaline + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18279", "l": "a methyl thioether + H(+) + S-adenosyl-L-homocysteine => a thiol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031817", "l": "P2Y8 nucleotide receptor binding", "d": ["Binding to a P2Y8 nucleotide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9858321", "l": "DHTKD1 dimer decarboxylates 2-OA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50011", "l": "6-methylpretetramide + 2 H(+) + NADPH + O2 <=> 4-hydroxy-6-methylpretetramide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.-", "l": "\"Peptidyl-amino-acid hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451561", "l": "NEMO binds polyubiquitinated IRAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9854315", "l": "CSKMT methylates Citrate Synthase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034387", "l": "4-aminobutyrate:pyruvate transaminase activity", "d": ["Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814555", "l": "Integrator complex processes the 3' end of snRNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51680", "l": "(2E,6E)-farnesol + CTP = (2E,6E)-farnesyl phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661117", "l": "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13785", "l": "(3S)-citramalyl-CoA = H2O + itaconyl-CoA", "d": [], "t": []}, {"i": "EC:4.2.1.56", "l": "\"itaconyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604731", "l": "Autocatalytic activation of MMP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76426", "l": "N-atom dealkylation of caffeine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623355", "l": "ESR1-dependent CCND1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72811", "l": "L-arginine(out) + N(omega),N(omega)-dimethyl-L-arginine(in) = L-arginine(in) + N(omega),N(omega)-dimethyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23190", "l": "3-hydroxypropanal + H(+) + NADH => NAD(+) + propane-1,3-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31941", "l": "DIBOA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69042", "l": "2-nitrobutanedioate + H2O + NADP(+) => (2S)-2-nitrosobutanedioate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.112", "l": "\"adenylate dimethylallyltransferase (ADP/ATP-dependent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210923", "l": "cya and lef bind to pagA(197-794):ANTXR1 oligomer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648017", "l": "EML4 binds to microtubules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604722", "l": "Activation of proMMP9 by proteases (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449855", "l": "IL10 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72631", "l": "Formation of the cap-binding eIF4F complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62527", "l": "cytidine(839) in 12S rRNA + S-adenosyl-L-methionine <=> H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50584", "l": "13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9860273", "l": "Dimerization of p-S446-IRF5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357445", "l": "PAK1-3 dimer disassociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68603", "l": "ORC5 binds ORC2:ORC3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56468", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 bromide + 3 FADH2 + 3 O2 = (3,4,5-tribromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 3 FAD + 6 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.57", "l": "\"1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] brominase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29475", "l": "(2E,6E)-farnesyl diphosphate = (+)-cubenene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.63", "l": "\"(+)-cubenene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1307963", "l": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78887", "l": "H2O + N-deacetylisoipecoside = D-glucose + N-deacetylisoipecoside aglycone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222093", "l": "BRD7 binds TP53 and EP300 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374673", "l": "L1 binds RanBPM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46827", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030369", "l": "ICAM-3 receptor activity", "d": ["Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198870", "l": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937989", "l": "RUNX1 binds PRC1 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013006", "l": "RHOA:GTP translocates to the ER membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74166", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191656", "l": "Closure of gap junction (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37685", "l": "1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22561", "l": "(3R)-vestitone + NADP(+) => 2'-hydroxyformononetin + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140522", "l": "fusogenic activity", "d": ["The activity of joining two lipid bilayers to form a single membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45911", "l": "chloroorienticin B + dTDP-beta-L-vancosamine <=> chloroeremomycin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0016753", "l": "O-sinapoyltransferase activity", "d": ["Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74942", "l": "2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + O2 <=> a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46591", "l": "calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcidiol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110311", "l": "POLZ extends translesion synthesis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9858647", "l": "HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733247", "l": "YBX1 binds COL1A2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51238", "l": "GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate => GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784399", "l": "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177920", "l": "Binding of GRB2 to GAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761047", "l": "HEYL binds CDH11 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27478", "l": "2-oxoglutarate + O2 + thebaine => CO2 + formaldehyde + neopinone + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62607", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> 7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37531", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78448", "l": "a globoside Gb3Cer (d18:1(4E)) + H2O => a fatty acid + a lysoGb3(d18:1(4E))", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28039", "l": "[thioredoxin]-disulfide + dCDP + H2O => [thioredoxin]-dithiol + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15968", "l": "1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30776", "l": "H2O + O2 + pyridoxamine => H2O2 + NH4(+) + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693055", "l": "TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698925", "l": "Packaging of Viral Genome Into C Capsids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199518", "l": "C3d-complexed antigen binds to complement receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018777", "l": "1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity", "d": ["Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604360", "l": "Initial activation of proMMP2 by MMP14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66092", "l": "3-phenylpyruvate + L-kynurenine = H2O + kynurenate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008867", "l": "galactarate dehydratase activity", "d": ["Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52675", "l": "2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate <=> [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029456", "l": "RAC1 and CDC42 activate PAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879459", "l": "F-actin capping protein is a heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72671", "l": "eIF5B:GTP is hydrolyzed and released (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4086083", "l": "SUMOylation of ING2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51169", "l": "(R)-adrenaline + H2O + O2 => (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9865449", "l": "Metallochaperone inserts Cu2+ into MT-CO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16666", "l": "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O => (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53560", "l": "9,10-epoxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9,10-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641147", "l": "DACT1 binds DVL2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63544", "l": "H2O + kinetensin = kinetensin-(1-8) + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4332236", "l": "CBL neddylates TGFBR2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13544", "l": "H2O + tetrathionate <=> H(+) + sulfate + sulfur + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52059", "l": "12-hexadecanoyloxy-octadecanoate + H2O <=> 12-hydroxyoctadecanoate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27392", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O <=> pyruvate + salicylaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51006", "l": "an aldehyde + 2 Fe(II)-[cytochrome cL] + 2 H(+) => a primary alcohol + 2 Fe(III)-[cytochrome cL]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-452097", "l": "Recruited STAT5 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371385", "l": "TNF-α is cleaved by ADAM17 (TACE) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9726862", "l": "Phosphorylated RHOU translocates to the endosome membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53700", "l": "2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36302", "l": "(E)-caffeate + ATP + CoA <=> (E)-caffeoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60149", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + ATP + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800794", "l": "PIDD1 associates with CRADD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000234", "l": "phosphoethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27949", "l": "dopamine + H2O + O2 <=> 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61993", "l": "N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.175", "l": "\"D-xylose 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9737780", "l": "MTTP binds lomitapide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76011", "l": "(3R)-hydroxybutanoate tetramer + H2O = (3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649856", "l": "Oxidative damage to the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626914", "l": "α2-agonists bind ADRA2A,B,C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0022855", "l": "protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34788", "l": "a 3beta-hydroxysteroid + NADP(+) => a 3-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13084", "l": "biotin amide + H2O <=> biotin + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109955", "l": "Formation of ERCC1:XPF heterodimeric complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10268", "l": "2-dehydro-3-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.2.20", "l": "\"2-dehydro-3-deoxyglucarate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050281", "l": "serine-glyoxylate transaminase activity", "d": ["Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9613570", "l": "Class III (KCNA5) antiarrhythmics bind KCNA5 tetramers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60072", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADH + O2 = 4beta-hydroxymethyl-4alpha-methylzymosterol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15029", "l": "D-mannitol + NAD(+) = D-mannose + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.255", "l": "\"mannitol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939904", "l": "Activated ESR1 binds the RUNX2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786118", "l": "IL13 binds IL13RA:TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68595", "l": "(6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O <=> (6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090722", "l": "receptor-receptor interaction", "d": ["The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909724", "l": "Recruitment of IFNAR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802919", "l": "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40418", "l": "H2O + pristanoyl-CoA <=> 2,6,10,14-tetramethylpentadecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769316", "l": "NPAS4 binds NAMPT gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27675", "l": "ATP + dADP => ADP + dATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388560", "l": "EDNRA,EDNRB bind EDNs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71206", "l": "L-homoarginine(in) <=> L-homoarginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-378975", "l": "Follitropin is a heterodimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021596", "l": "Membrane estrogen receptors bind SRC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044025", "l": "histone H2BS14 kinase activity", "d": ["Catalysis of the reaction: histone H2B-serine (position 14) + ATP = histone H2B-phosphoserine (position 14) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 14 of histone H2B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9824995", "l": "GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008676", "l": "3-deoxy-8-phosphooctulonate synthase activity", "d": ["Catalysis of the reaction: D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48082", "l": "ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9834821", "l": "p-PRKRA dimer binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442749", "l": "CaMKK autophosphorylates in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11186", "l": "beta-alanine + CO2 + NH4(+) => 3-(carbamoylamino)propanoate + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173739", "l": "Spontaneous hydrolysis of C3 thioester (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11960", "l": "2-oxoglutarate + N-succinyl-(2S,6S)-2,6-diaminoheptanedioate = (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.17", "l": "\"succinyldiaminopimelate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70679", "l": "ALDH4A1 oxidises L-GluSS to Glu (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41148", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13751", "l": "a ribonucleoside 5'-diphosphate + ADP => a ribonucleoside 5'-triphosphate + AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19400", "l": "(R)-4'-phosphopantothenate + CTP + L-cysteine <=> CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429698", "l": "PRKD1,2,3 phosphorylates CERT1-2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61724", "l": "a D-glucoside + NAD(+) = a 3-dehydro-D-glucoside + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35273", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA => a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75596", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate => 11-hydroxy-12,13-epoxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33104", "l": "(2E,6E)-farnesyl diphosphate => alpha-muurolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56054", "l": "2 alpha-D-mannopyranose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => 2 H2O + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23845", "l": "ATP + sedoheptulose => ADP + D-sedoheptulose 7-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60583", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45159", "l": "3-oxopropanoyl-CoA + H2O <=> 3-oxopropanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65895", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate <=> H2O + xanthurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086058", "l": "voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an Purkinje myocyte cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614591", "l": "Excess cysteine yields lanthionine and H2S (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-188390", "l": "Cyclin E:CDK2-mediated phosphorylation of RB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-532549", "l": "MPI isomerises Fru6P to Man6P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198813", "l": "GSTO dimers reduce DeHA to AscH- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9854984", "l": "Transfer of Fe-S clusters to SDHB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371422", "l": "ATP hydrolysis by HSP70 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788582", "l": "STAT1,STAT3,STAT6 phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3095889", "l": "MMACHC dealkylates RCbl (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25630", "l": "myricetin + S-adenosyl-L-methionine => H(+) + laricitrin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34906", "l": "4 glutathione + 2 H(+) + selenite <=> glutathione disulfide + 3 H2O + selenodiglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77344", "l": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39235", "l": "(3R)-hydroxytriacontanoyl-CoA = (2E)-triacontenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-198669", "l": "p38MAPK phosphorylates MSK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1912369", "l": "NOTCH precursor cleaved to form mature NOTCH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31314", "l": "(2R)-3-phosphoglycerate + ADP-alpha-D-glucose <=> (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-508179", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22870", "l": "chloride + H(+) + S-carboxymethyl-L-cysteine => 3-chloro-L-alanine + thioglycolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32363", "l": "L-gulono-1,4-lactone + O2 = H(+) + H2O2 + L-ascorbate", "d": [], "t": []}, {"i": "EC:1.1.3.8", "l": "\"L-gulonolactone oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72666", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-phenylalanyl-[tubulin] + H2O <=> C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52231", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 <=> 3 A + biliverdin IXbeta + CO + Fe(2+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950740", "l": "CANX dissociates from IL12A:EBI3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34933", "l": "glutathione + hydrogenselenide + NADP(+) => glutathioselenol + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6806732", "l": "GNLY binds the bacterial cell surface (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51051", "l": "5alpha-androstan-3,17-dione + A <=> AH2 + androst-4-ene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68946", "l": "H(+) + isoscopoletin + S-adenosyl-L-homocysteine => esculetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55798", "l": "H2O + hydroquinone + NAD(+) => H(+) + NADH + O2 + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34478", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate <=> 15-cis-phytoene + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912385", "l": "Phosphorylated NICD1 binds FBXW7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381412", "l": "IGFBP2 binds IGF forming IGF:IGFBP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696101", "l": "ALDH8A1 oxidises 9cRAL to 9cRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24808", "l": "(2S)-2-acetolactate + thiamine diphosphate <=> 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354149", "l": "Interaction of integrin alphaIIb beta3 with Fibrinogen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50746", "l": "2 aminomethylphosphonate + 2 glyoxylate + 2 H(+) => 2 glyphosate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2464822", "l": "RDH12 reduces atRAL to atROL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51982", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O => an L-N,N-dihydroxypolyhomomethionine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629499", "l": "NEIL3 cleaves thymine glycol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070139", "l": "SUMO-specific endopeptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56250", "l": "2-dodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl dodecanoate + apo--[retinol-binding protein] => 1,2-didodecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25789", "l": "4-hydroxy-2-oxoheptanedioate => pyruvate + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73374", "l": "(R)-pantothenate(out) + 2 Na(+)(out) <=> (R)-pantothenate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46251", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2 <=> (14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855228", "l": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19079", "l": "3-deoxyglucosone + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54437", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 => a (4S)-2,3-dehydroflavan-3,4-diol + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77767", "l": "11-cis-retinol + a fatty acyl-CoA = 11-cis-retinyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31700", "l": "4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin] => 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60509", "l": "a guanosine in mRNA + S-adenosyl-L-methionine => an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021609", "l": "ESR-associated SRC autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45822", "l": "2-methylfumaryl-CoA + succinate => mesaconate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9611751", "l": "β1,2-agonists bind ADRB1,2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17015", "l": "3-phosphonopyruvate => H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51712", "l": "keto-D-tagatose 6-phosphate = keto-D-fructose 6-phosphate", "d": [], "t": []}, {"i": "EC:5.1.3.40", "l": "\"D-tagatose 6-phosphate 4-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198756", "l": "ERK1/2 phosphorylates MSK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70168", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688294", "l": "SIRT5 deacetylates Cytochrome C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624526", "l": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46942", "l": "ATP + holo-[LYS2 peptidyl-carrier protein] + L-2-aminoadipate => AMP + diphosphate + L-2-aminoadipyl-[LYS2 peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102881", "l": "(+)-beta-barbatene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-beta-barbatene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48442", "l": "a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-215526", "l": "CYP4F3 20-hydroxylates LTB4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72877", "l": "anthocyanin A9 + CoA => anthocyanin A7 + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696358", "l": "TREM,CD300 binds lipids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428585", "l": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75740", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH => 10-oxooctadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862320", "l": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070038", "l": "rRNA (pseudouridine-N3-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141097", "l": "ligand-activated transcription activator activity", "d": ["A DNA-binding transcription activator activity regulated by binding to a ligand and that activates the transcription of specific genes and gene sets."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868344", "l": "CDK5:p25 phosphorylates lamin A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46723", "l": "(3R)-hydroxyhexanoyl-CoA <=> (2E)-hexenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685366", "l": "GRB2-1:SOS1 binds p-Y-SHC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64557", "l": "3-[(2E,4E,8S,10E,12Z)-4,8-dimethyltetradeca-2,4,10,12-tetraenoyl]-4-hydroxy-5-(4-hydroxyphenyl)-1,2-dihydropyridin-2-one => 8-epi-ilicicolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43785", "l": "adenosine(2142) in 25S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(2142) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14275", "l": "4-aminobutanal + AH2 + propane-1,3-diamine => A + H2O + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51755", "l": "a 2-acylphloroglucinol + dimethylallyl diphosphate <=> a 2-acyl-4-prenylphloroglucinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730837", "l": "Recruitment of GRB2:SOS to p-10Y-NTAL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.90", "l": "\"glyceraldehyde-3-phosphate dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27402", "l": "2-hydroxychromene-2-carboxylate => (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695828", "l": "FLT3 binds type I TKI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57788", "l": "1,3-dinitrobenzene + NADH + O2 = 4-nitrocatechol + H(+) + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112385", "l": "Addition of nucleotides leads to transcript elongation (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57493", "l": "H2O + oxaloacetate + propanoyl-CoA => 2-methylcitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944214", "l": "Association of procollagen type I (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48531", "l": "a ganglioside GP1c (d18:1(4E)) + H2O <=> a ganglioside GQ1c (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607023", "l": "factor IXa associates with cell membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54552", "l": "1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + nonanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033149", "l": "FFAT motif binding", "d": ["Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018894", "l": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759176", "l": "NFE2L2-dependent HMOX1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45106", "l": "mitomycin A + S-adenosyl-L-homocysteine => 6-demethylmitomycin A + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51725", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate => adenosine 5'-tetraphosphate + ADP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77467", "l": "butan-2-one + hydrogen cyanide = 2-hydroxy-2-methylbutanenitrile", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21112", "l": "a globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose", "d": [], "t": []}, {"i": "EC:3.2.1.22", "l": "\"alpha-galactosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17884", "l": "H2O + N-sulfo-D-glucosamine <=> D-glucosamine + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40305", "l": "(2E)-dodecenedioyl-CoA + AH2 => A + dodecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-888577", "l": "Synthesis of GABA by GAD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425861", "l": "Activation of Protein Kinase C novel isoforms (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14038", "l": "4,5beta-dihydrocortisone + NADP(+) => cortisone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008448", "l": "N-acetylglucosamine-6-phosphate deacetylase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209738", "l": "VD3 binds GC (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668984", "l": "PAK1 or PAK2 phosphorylates MYLK (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65081", "l": "asperaculane D + O2 + reduced [NADPH--hemoprotein reductase] => asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005367", "l": "myo-inositol:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)."], "t": []}, {"i": "REACT:R-HSA-429663", "l": "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18143", "l": "2-hydroxycyclohexan-1-one + H(+) + NADH => NAD(+) + trans-cyclohexane-1,2-diol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58209", "l": "A + dihydroalstonine => AH2 + alstonine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44014", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP] => (9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48904", "l": "L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40603", "l": "1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-901047", "l": "Binding of ERp57 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71467", "l": "H2O + substance P = L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50677", "l": "H(+) + H2O + N-terminal L-asparaginyl-[protein] => N-terminal L-aspartyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68999", "l": "2-oxoglutarate + gibberellin A9 + O2 <=> CO2 + gibberellin A4 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24021", "l": "2-(N(omega)-L-arginino)succinate => fumarate + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11704", "l": "2 H(+) + N-(carboxyaminomethyl)urea = CO2 + N-(aminomethyl)urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25776", "l": "scyllo-inosose = scyllo-inosine", "d": [], "t": []}, {"i": "EC:5.3.99.11", "l": "\"2-keto-myo-inositol isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21018", "l": "L-aspartate + NH4(+) => H2O + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395818", "l": "NUDT1 hydrolyses 2-oxo-dATP to 2-oxo-dAMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64051", "l": "(13Z)-docosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(13Z-docosenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49356", "l": "2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77210", "l": "3'-phosphoadenylyl sulfate + glycodeoxycholate <=> 3alpha-sulfoglycodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34862", "l": "3-oxocyclopentanecarbonitrile + 2 H2O <=> 3-oxocyclopentanecarboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66798", "l": "11-oxomiltiradiene + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => miltiradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72350", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole <=> 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69127", "l": "Formation of the Flap Intermediate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41563", "l": "(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 <=> (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72080", "l": "3 Na(+)(out) + selenate(out) => 3 Na(+)(in) + selenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70613", "l": "GOT2 transaminates OA and L-Glu (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046090", "l": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62261", "l": "2 hydrogencarbonate(out) + Mn(2+)(out) => 2 hydrogencarbonate(in) + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63258", "l": "1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) => 1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109858", "l": "MAP2K2 binds MAPK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161949", "l": "HXA3/B3 is hydrolysed to TrXA3/B3 by HXEH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103088", "l": "2-(6'-methylthio)hexylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-8-methylthiooctanoate + acetyl-CoA + H2O = H+ + 2-(6'-methylthio)hexylmalate + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10074", "l": "glycine betaine + H(+) + S-adenosyl-L-homocysteine => N,N-dimethylglycine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57034", "l": "CO2 + formate + methylamine + succinate semialdehyde => (E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61434", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (R)-8-oxocitronellyl enol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2272668", "l": "Interaction of DAP12 and KIR2DS5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9861725", "l": "PGAM5 dodecamer dephosphorylates p-S336-ME1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33087", "l": "cyclic dehypoxanthinylfutalosinate = 1,4-dihydroxy-6-naphthoate + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35580", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8 => anthocyanin A11 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823950", "l": "Expression of CXCR4 in definitive endoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69335", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44157", "l": "1D-myo-inositol 5-phosphate + H2O => myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53968", "l": "apo-[BtrI ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[BtrI ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12173", "l": "alpha-D-glucosamine 6-phosphate + H2O => beta-D-fructose 6-phosphate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65313", "l": "an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61783", "l": "keto-L-tagatose <=> keto-L-sorbose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827862", "l": "SOX17 and TFAP2C bind the CBFA2T2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624953", "l": "ARL13B binds INPP5E (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247844", "l": "WNT ligands traffic to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67450", "l": "formyl-CoA + heptadecanal => (2R)-2-hydroxyoctadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71007", "l": "L-phenylalanine(out) + L-tryptophan(in) = L-phenylalanine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36082", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine <=> a 1,2-diacyl-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74382", "l": "2 (S)-lactate(in) + prostaglandin H2(out) <=> 2 (S)-lactate(out) + prostaglandin H2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68245", "l": "L-phenylalanine(in) + Na(+)(in) => L-phenylalanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9006870", "l": "IL21 receptor STAT phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851988", "l": "BTN2A2 binds T cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9658253", "l": "RAS:GTP binds PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757698", "l": "PREDN,PREDL diffuse into hepatic cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2404193", "l": "IGF1R phosphorylates SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77002", "l": "H(+) + NAD(+) + reduced [4Fe-4S]/[3Fe-4S]-[ferredoxin] <=> NADH + oxidized [4Fe-4S]/[3Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57168", "l": "(R)-2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70642", "l": "H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67799", "l": "a ribonucleotidyl-ribonucleotide-RNA <=> a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033984", "l": "indole-3-glycerol-phosphate lyase activity", "d": ["Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73696", "l": "dADP(out) + H(+)(out) + phosphate(in) => dADP(in) + H(+)(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35080", "l": "doxorubicin(in) => doxorubicin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950766", "l": "IL27RA dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14780", "l": "AMP + H(+) + H2O <=> IMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0061593", "l": "sulfoquinovose isomerase activity", "d": ["Catalysis of the reaction sulfoquinovose = 6-deoxy-6-sulfofructose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63827", "l": "2 3-(4-hydroxyphenyl)pyruvate <=> aspulvinone E + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51833", "l": "ATP(in) + CoA(in) + H(+)(out) + tetracosanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + tetracosanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213246", "l": "Disassociation of CLIP from MHC II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033741", "l": "adenylyl-sulfate reductase (glutathione) activity", "d": ["Catalysis of the reaction: AMP + glutathione disulfide + H+ + sulfite = 5'-adenylyl sulfate + 2 glutathione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824977", "l": "MAPK1-dependent phosphorylation of MITF-M (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103061", "l": "trans-methoxy-C60-meroacyl-AMP ligase activity", "d": ["Catalysis of the reaction: ATP(4-) + H2O + a trans-methoxy-C60-meroacyl-[acp] = diphosphoric acid + a trans-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-391941", "l": "BLT receptors can bind LTB4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24183", "l": "2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] <=> CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814409", "l": "CK2 phosphorylates PDCL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61375", "l": "4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O <=> 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77324", "l": "glyoxylate + N(omega)-methyl-L-arginine => 5-(3-methylguanidino)-2-oxopentanoate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52141", "l": "a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O => a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54942", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + CO2 + holo-[ACP] => (3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046093", "l": "Translocation of tetracosapentaenoyl-CoA to peroxisomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396370", "l": "VTN binds collagens II, III and V (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48102", "l": "H(+) + N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => L-arginyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018804", "l": "RAC3 GEFs activate RAC3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71880", "l": "2'-deoxyguanosine + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74215", "l": "HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60923", "l": "2-oxoglutarate + an N(3)-methylcytidine in mRNA + O2 <=> a cytidine in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110133", "l": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46544", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.17", "l": "\"sphingolipid 4-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2106625", "l": "Duplex siRNA is loaded into Argonaute (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43960", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64256", "l": "dodecanoyl-CoA + glycine = CoA + H(+) + N-dodecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14265", "l": "(S)-4-amino-5-oxopentanoate = 5-aminolevulinate", "d": [], "t": []}, {"i": "EC:5.4.3.8", "l": "\"glutamate-1-semialdehyde 2,1-aminomutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5615668", "l": "AKR1C3 reduces atRAL to atROL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9730412", "l": "MITF gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31191", "l": "(3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34128", "l": "(2E)-geranyl diphosphate + olivetolate => cannabigerolate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35986", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5578742", "l": "AGO1,2:small RNA complexes interact with chromatin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27506", "l": "cocaine + H2O = benzoate + ecgonine methyl ester + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.84", "l": "\"cocaine esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209118", "l": "Membrane localised SGG phosphorylates ARR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031805", "l": "type 8 metabotropic glutamate receptor binding", "d": ["Binding to a type 8 metabotropic glutamate receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69631", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-{alpha-D-Man-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20259", "l": "3-methyleneoxindole + H(+) + NADPH => 3-methyloxindole + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0004656", "l": "procollagen-proline 4-dioxygenase activity", "d": ["Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.94", "l": "\"ethylmalonyl-CoA decarboxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784763", "l": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114284", "l": "Release of Cytochrome c from mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42712", "l": "S-adenosyl-L-methionine + uridine(54) in tRNA = 5-methyluridine(54) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.35", "l": "\"tRNA (uracil(54)-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67289", "l": "ATP + 12 H(+) + L-leucine + 8 malonyl-CoA + 9 NADPH + 4 S-adenosyl-L-methionine => (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 8 CO2 + 8 CoA + diphosphate + 7 H2O + 9 NADP(+) + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23214", "l": "acetate + beta-alanine => H2O + N-acetyl-beta-alanine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58988", "l": "(E)-4-hydroxynon-2-enal + H2O + O2 = (E)-4-hydroxynon-2-enoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8865275", "l": "PDGF-BB clevage by Furin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18962", "l": "D-allose + L-lysyl-[protein] => H2O + N(6)-(D-psicosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605797", "l": "SMPD1 hydrolyzes SPHM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10215", "l": "2-oxoglutarate + 5-aminopentanoate <=> 5-oxopentanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43428", "l": "1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.-.-.-", "l": "\"Hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375395", "l": "C5a receptor binds C5a anaphylatoxin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.368900840266221", "identifiers": [{"i": "GO:0016408", "l": "C-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54605", "l": "2-oxoglutarate + decanoyl-CoA + O2 => 2-hydroxydecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13546", "l": "(6E,10E)-geranyllinalool + O2 + reduced [NADPH--hemoprotein reductase] => (3E,7E)-4,8,12-trimethyltrideca 1,3,7,11-tetraene + but-3-en-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78018", "l": "a 1,2-diacylglycerol + H2O <=> a 2-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23995", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA <=> 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9821366", "l": "AKAP8L binds MLL2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47728", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944457", "l": "MAF1 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190520", "l": "Association of Golgi  transport vesicles with microtubules (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849085", "l": "ARHGAP35 binds RHOA:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0016672", "l": "oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound."], "t": []}, {"i": "EC:1.8.5.-", "l": "\"With a quinone or similar compound as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949668", "l": "YME1L1 proteolyzes unassembled proSMDT1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9737780", "l": "MTTP binds lomitapide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41912", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADPH = hexadecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26038", "l": "2 flaviolin + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3,8'-biflaviolin + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444691", "l": "Prokineticin receptors bind prokineticin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-419166", "l": "GEFs activate RhoA,B,C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63885", "l": "H2O2 + L-tyrosine => H2O + L-dopa", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13156", "l": "(R)-glycerate + CO2 + NAD(+) <=> 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64663", "l": "a long-chain fatty acid + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] <=> a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55889", "l": "[aequorin]--dioxetanone => [excited state blue fluorescent protein] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20361", "l": "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29221", "l": "a menaquinol + dihydroxyacetone phosphate => a menaquinone + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61561", "l": "gibberellin A15 + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A24 + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25076", "l": "(9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O => (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73666", "l": "dUTP + H2O => dUMP + pyrophosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033749", "l": "histone H4R3 demethylase activity", "d": ["Catalysis of the removal of the methyl group from a modified arginine residue at position 3 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17137", "l": "prostaglandin H2 = thromboxane A2", "d": [], "t": []}, {"i": "EC:5.3.99.5", "l": "\"thromboxane-A synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55495", "l": "ent-cassa-12,15-dien-2-one + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-3beta-hydroxycassa-12,15-dien-2-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31086", "l": "H2O + N-acetyl-D-muramoyl-L-alanine <=> L-alanine + N-acetyl-D-muramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9846477", "l": "A4GALT transfers galactose to LacCer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27979", "l": "GDP-alpha-D-mannose + H2O => alpha-D-mannose 1-phosphate + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34298", "l": "2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose <=> 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234175", "l": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16227", "l": "N-(6-aminohexanoyl)-6-aminohexanoate => 1,8-diazacyclotetradecane-2,9-dione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34289", "l": "2 H2O + 2 L-dopaquinone => 2 L-dopa + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42801", "l": "15-cis-4,4'-diapophytoene + 3 FAD + 3 H(+) => all-trans-4,4'-diaponeurosporene + 3 FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655835", "l": "POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:1990188", "l": "euchromatin binding", "d": ["Binding to euchromatin, a dispersed and relatively uncompacted form of chromatin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.8", "l": "\"benzoyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1370500", "l": "PRLR binds SCF beta-TrCP complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840884", "l": "bHEXA,bHEXS hydrolyze GM2A:SM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56625", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O => 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836606", "l": "SPHK1 binds PKR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051670", "l": "inulinase activity", "d": ["Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801675", "l": "PLK2 phosphorylates NPM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14205", "l": "carnosine + S-adenosyl-L-methionine = anserine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.22", "l": "\"carnosine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57472", "l": "(E)-4-coumarate + UDP-alpha-D-glucose = 1-O-(trans-4-coumaroyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10950", "l": "ADP + D-glucosamine 6-phosphate + H(+) => ATP + D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22366", "l": "3-dehydroquinate + H(+) + NADH => L-quinate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985594", "l": "MYO9B inactivates RHOA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28016", "l": "methyl thiocyanate + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + thiocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31875", "l": "(S)-2,3-epoxysqualene = marneral", "d": [], "t": []}, {"i": "EC:5.4.99.53", "l": "\"marneral synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35658", "l": "2 ATP <=> 3',3'-c-di-AMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21526", "l": "(2S)-2-isopropylmalate + CoA + H(+) => 3-methyl-2-oxobutanoate + acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76518", "l": "H2O + orobanchol <=> 5-hydroxy-3-methylfuran-2(5H)-one + orobanchol ABC-rings", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50825", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 => 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22838", "l": "a 3-oxoacyl-[ACP] + CO2 + holo-[ACP] => a fatty acyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24227", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) <=> 4-methylcatechol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61407", "l": "ATP + N-(D-ribulosyl)-cadaverine <=> ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41728", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52828", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 = (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43552", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12176", "l": "phenylethanolamine + S-adenosyl-L-methionine = H(+) + N-methylphenylethanolamine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67287", "l": "(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione <=> (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12510", "l": "loganin + S-adenosyl-L-homocysteine => loganate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73481", "l": "D-histidine(out) + H(+)(out) + L-ornithine(in) => D-histidine(in) + H(+)(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549060", "l": "NrCAM binds Neuropilin-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936897", "l": "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72117", "l": "glycine betaine(in) + Na(+)(in) => glycine betaine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855159", "l": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40973", "l": "2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042020", "l": "interleukin-23 receptor activity", "d": ["Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001057", "l": "RNA polymerase IV activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63840", "l": "[thioredoxin]-dithiol + tert-butyl hydroperoxide = [thioredoxin]-disulfide + H2O + tert-butanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71976", "l": "glutathione(out) + 3 Na(+)(out) => glutathione(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "65.399109570171689", "identifiers": [{"i": "GO:0015078", "l": "proton transmembrane transporter activity", "d": ["Enables the transfer of a proton from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655290", "l": "Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9011748", "l": "IL9R binds JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140869", "l": "miRNA inhibitor activity via base-pairing", "d": ["Stops, prevents or reduces the activity of miRNA-mediated gene silencing activity by base-pairing with a target miRNA. An example of this activity is mediated by long non-coding RNAs (lncRNAs)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75529", "l": "benzaldehyde + FMN + H(+) + H2O + N-acetyl-S-hydroxy-L-cysteine => (R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.46", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70690", "l": "4-aminobutanoate(out) + chloride(out) + 2 Na(+)(out) <=> 4-aminobutanoate(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080130", "l": "L-phenylalanine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.5", "l": "\"chondroitin AC lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9640195", "l": "RRAGA,B hydrolyzes GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43711", "l": "ATP + H(+) + hexadecanoate <=> diphosphate + hexadecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35643", "l": "a (2R)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46747", "l": "ATP + hydrogencarbonate <=> ADP + carboxyphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950347", "l": "IL12A:IL12B translocates from late endosome lumen to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625548", "l": "Hypochlorous acid (HOCL) oxidizes Cys residues to form Cys-sulfenyl chloride (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67335", "l": "13-cis-retinal + H2O + NAD(+) <=> 13-cis-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209297", "l": "PYGO binds to the LGS:ARM complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2172678", "l": "PHF8 demethylates histone H4K20me1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68717", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + germacrene D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54393", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72998", "l": "L-fucose(out) + 2 Na(+)(out) <=> L-fucose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78322", "l": "a III(4)-a-Fuc-Lc4Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71092", "l": "dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) => dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58980", "l": "citral + H2O + O2 = 3,7-dimethylocta-2,6-dienoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686587", "l": "ABL1 phosphorylates RAD52 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830362", "l": "Expression of PLAC8 in the nephric duct (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21142", "l": "ADP + H(+) + IMP => ATP + inosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41205", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+) => 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350769", "l": "trans-Golgi Network Coat Activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948775", "l": "MKRN1 polyubiquitinates PTEN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389352", "l": "Translocation of Vav1 to CD28 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193761", "l": "25(R) TetraHCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50276", "l": "(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813749", "l": "ALDH1A1 oxidises GA to DGA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35049", "l": "AMP + H2O + Mo-molybdopterin => adenylyl-molybdopterin + H(+) + molybdate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50878", "l": "a hydroxy polyunsaturated fatty acid + H2O + NADP(+) => a hydroperoxy polyunsaturated fatty acid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983696", "l": "The Immunoglobulin of the BCR binds antigen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21140", "l": "ATP + inosine = ADP + H(+) + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70467", "l": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.244991688848543", "identifiers": [{"i": "GO:0008353", "l": "RNA polymerase II CTD heptapeptide repeat kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47259", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782106", "l": "USP10 deubiquitinates SNX3, CFTR (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24479", "l": "H2O + maleimide <=> H(+) + maleamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35442", "l": "CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + L-serine <=> archaetidylserine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40980", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O => 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52969", "l": "hyocholate + UDP-alpha-D-glucuronate => H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110322", "l": "Formation of Pol zeta complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46588", "l": "calciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcidiol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798345", "l": "PXLP-GCAT dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944218", "l": "Association of procollagen type VIII (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43698", "l": "diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] => H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9737780", "l": "MTTP binds lomitapide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23322", "l": "CoA + H(+) + N(2)-malonyl-D-tryptophan => D-tryptophan + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9825788", "l": "p-S207 KARS displaces HINT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23260", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31677", "l": "H(+) + NADPH + perakine => NADP(+) + raucaffrinoline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45605", "l": "D-glucaro-1,4-lactone => 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798474", "l": "S100A8:S100A9 binds Zn2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467775", "l": "Autocleavage of ESPL1 (Separase) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102467", "l": "scutellarein 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate + scutellarein = UDP( + scutellarin + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874082", "l": "MET phosphorylates PTK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53468", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871226", "l": "RET binds GFRA1,GFRA2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10260", "l": "ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.14", "l": "\"P-type Mg(2+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79123", "l": "cholate + L-phenylalanine = H2O + L-phenylalanocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009936", "l": "RNASEL cleaves cellular ssRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694417", "l": "SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28312", "l": "alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+) => beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58094", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10471", "l": "D-xylulose 5-phosphate + phosphate <=> acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78198", "l": "a 3beta-hydroxysteroid + a triacylglycerol <=> a 1,2-diacylglycerol + a 3beta-hydroxysteroid ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638012", "l": "PDE6D dissociates from ARL13B:INPP5E (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418904", "l": "A1 and A3 receptors bind adenosine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033927", "l": "glucan 1,4-alpha-maltohexaosidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25602", "l": "4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O => 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052756", "l": "chitobiose phosphorylase activity", "d": ["Catalysis of the reaction: chitobiose + phosphate = N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate. This reaction is the phosphorolysis of chitobiose, (GlcNAc)2, a dimer of beta-(1->4) linked glucosamine units."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41830", "l": "(2E)-hexenoyl-[ACP] + H2O => (3R)-hydroxyhexanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5140741", "l": "WNT5A binds FZD and ROR receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40806", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) <=> 3,6-anhydro-L-galactonate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9833635", "l": "p-PKR dimer localizes to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24372", "l": "H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] = H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine", "d": [], "t": []}, {"i": "EC:3.1.4.45", "l": "\"N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2993802", "l": "HLCS biotinylates PC:Mn2+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23354", "l": "L-glutamate + succinate semialdehyde => 2-oxoglutarate + 4-aminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601897", "l": "MeR-PIWIL4:2'-O-methyl-piRNA:TDRD9:MAEL:TDRKH dissociates and MeR-PIWIL4:2'-O-methylpiRNA, TDRD9, MAEL translocate from cytosol to nucleus in an unknown association and order of events (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34252", "l": "1-deoxysphinganine + NADP(+) => 1-deoxy-3-dehydrosphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793400", "l": "NOTCH1 coactivator complex binds the TBX6 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804596", "l": "APAF1:CYCS binds APIP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-166220", "l": "FA anion diffuses laterally to UCP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682011", "l": "LC3 binds ATG7 dimer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990882", "l": "CDK1 phosphorylates NUP98 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419145", "l": "5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79095", "l": "an L-alpha-amino acid + glycocholate = an N-choloyl-L-alpha-amino acid + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22341", "l": "3-hydroxybenzyl alcohol + NADP(+) => 3-hydroxybenzaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46169", "l": "ATP + CoA + pentanoate => AMP + diphosphate + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17623", "l": "(3S)-citramalyl-CoA + acetate => acetyl-CoA + citramalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432232", "l": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65457", "l": "2-methylbutan-1-ol + acetyl-CoA => 2-methylbutyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844587", "l": "GAL3ST1 transfers sulfate to GalCer,LacCer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879245", "l": "mycothiol binds formaldehyde and is dehydrogenated (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23526", "l": "an alkyl cinnamate + beta-D-glucose => 1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45812", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.134", "l": "\"very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36854", "l": "(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607747", "l": "TRAF6 binds MALT1 oligomers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30579", "l": "H2O + O-phospho-L-threonine = L-threonine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5671763", "l": "p-T774-PKN1 phosphorylates PPP1R14A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74775", "l": "kaempferide + S-adenosyl-L-methionine = 7,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43348", "l": "cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z-octadecenoate)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11568", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP = 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate", "d": [], "t": []}, {"i": "EC:2.1.1.54", "l": "\"deoxycytidylate C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868648", "l": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15644", "l": "H(+) + oxaloacetate <=> CO2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641206", "l": "RSPOs bind LGRs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31693", "l": "(9R)-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662986", "l": "MT2A binds copper (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53523", "l": "1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol <=> (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69372", "l": "2-hydroxyhexanoate + O2 = 2-oxohexanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "45.852120989302804", "identifiers": [{"i": "GO:0022803", "l": "passive transmembrane transporter activity", "d": ["Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67401", "l": "(2E,6E)-farnesyl diphosphate => allo-aromadendrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48273", "l": "2-methylhexanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => 2-methylhexenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39259", "l": "(3R)-hydroxy-(13Z)-docosenoyl-CoA = (2E,13Z)-docosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60931", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41165", "l": "1-O-hexadecyl-2-desoxy-2-amino-sn-glycero-3-phosphate + ADP + H(+) => 1-O-hexadecyl-2-amino-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16332", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 <=> (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033891", "l": "CC-preferring endodeoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625424", "l": "The retrograde IFT train dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450984", "l": "IDH2 dimer decarboxylates isocitrate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74642", "l": "AMP(out) + CMP-N-acetyl-beta-neuraminate(in) <=> AMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49472", "l": "trans-4-hydroxy-L-prolyl-[protein] + UDP-beta-L-arabinofuranose = H(+) + O-(beta-L-arabinofuranosyl)-trans-4-hydroxy-L-prolyl-[protein] + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.58", "l": "\"hydroxyproline O-arabinosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77289", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA => 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20064", "l": "2'-deoxycytidine + a ribonucleoside 5'-triphosphate <=> a ribonucleoside 5'-diphosphate + dCMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209815", "l": "Tyrosine is monoiodinated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38361", "l": "thiosulfate + ubiquinol-10 => 2 H(+) + hydrogen sulfide + sulfite + ubiquinone-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43581", "l": "A + D-arginine => AH2 + iminoarginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2220981", "l": "NOTCH1 PEST domain mutants stimulate HEY transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60038", "l": "3-hydroxy-3-methylhexanoate + L-glutamine => H2O + N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32125", "l": "citrate(out) + H(+)(out) => citrate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110359", "l": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19711", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CoA => a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75193", "l": "2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH => 2-dehydro-3-deoxy-L-fuconate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-880002", "l": "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73779", "l": "dimethylallyl diphosphate + preechinulin = diphosphate + tardioxopiperazine A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16049", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102534", "l": "apigenin-7,4'-dimethyl ether 6-hydroxylase activity", "d": ["Catalysis of the reaction: apigenin-7,4'-dimethyl ether + O2 + NADPH + H+ = ladanein + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395412", "l": "Phosphorylation of SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004514", "l": "nicotinate-nucleotide diphosphorylase (carboxylating) activity", "d": ["Catalysis of the reaction: CO2 + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981832", "l": "NMUR2 binds neuromedin-S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47746", "l": "demethylphylloquinol + NADP(+) => demethylphylloquinone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31070", "l": "6-amino-2-oxohexanoate <=> Delta(1)-piperideine-2-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42752", "l": "pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.177", "l": "\"23S rRNA (pseudouridine(1915)-N(3))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617848", "l": "CDKN1B gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45969", "l": "androst-4-ene-3,17-dione + H(+) + NADH + O2 => 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30425", "l": "(+)-delta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25499", "l": "(2E)-geranyl diphosphate <=> (1S,5S)-beta-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28617", "l": "(1Z,2S)-2-methylbutanal oxime <=> (2S)-2-methylbutanenitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24564", "l": "a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76155", "l": "21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 19-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24768", "l": "7(1)-hydroxychlorophyllide a + NAD(+) = chlorophyllide b + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68465", "l": "2-butyloctyl sulfate + H2O => 2-butyloctan-1-ol + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047274", "l": "galactinol-sucrose galactosyltransferase activity", "d": ["Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029566", "l": "Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48975", "l": "ATP + H2O + phosphite(out) <=> ADP + H(+) + phosphate + phosphite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70763", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18888", "l": "GDP-beta-L-fucose + NADP(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16368", "l": "digallate + H2O <=> 2 3,4,5-trihydroxybenzoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514865", "l": "cGMP dissociates from CNG channels (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72621", "l": "Ribosomal scanning  (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26280", "l": "Co-precorrin-4 + S-adenosyl-L-methionine <=> Co-precorrin-5A + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53535", "l": "(14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate <=> (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12635", "l": "(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD(+) => benzoate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9749607", "l": "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205231", "l": "Dimerization of KIT upon SCF binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56396", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0140934", "l": "histone deubiquitinase activity", "d": ["A deubiquitinase that cleaves ubiquitin from a histone protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086205", "l": "OPN (osteopontin) degradation by MMP3, MMP7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23780", "l": "H2O + oxaloacetate + propanoyl-CoA = (2S,3S)-2-methylcitrate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.5", "l": "\"2-methylcitrate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62867", "l": "7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + S-adenosyl-L-methionine <=> 9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831166", "l": "Nascent N is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76290", "l": "Na(+)(out) + thymine(out) <=> Na(+)(in) + thymine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-430347", "l": "MigFilin associates with Filamin and F-actin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77302", "l": "a ubiquinone + H2O + theobromine <=> 3,7-dimethylurate + a ubiquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2530445", "l": "CD59 inhibits MAC formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57289", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O => a guanosine in RNA + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37902", "l": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 <=> 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.3.-", "l": "\"Phosphotransferases with a nitrogenous group as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948136", "l": "ULK1 Translocates to the mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2197698", "l": "Src phosphorylate WASP,N-WASP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140443", "l": "mitochondrion-plasma membrane adaptor activity", "d": ["The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46898", "l": "a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682967", "l": "WHSC1 binds DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20988", "l": "ATP + 2 H2O = AMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9825783", "l": "p-S207 KARS1 dimer translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76762", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,5-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033691", "l": "sialic acid binding", "d": ["Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199910", "l": "MSK1 activates ATF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52885", "l": "H2O + N-phenylhydroxylamine + 2 NADP(+) => 2 H(+) + 2 NADPH + nitrobenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73865", "l": "dopamine(in) => dopamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801109", "l": "CHM binds RGGT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68335", "l": "(R)-4'-phosphopantothenate + H2O <=> (R)-pantothenate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182994", "l": "Assembly of EGFR complex in clathrin-coated vesicles (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28063", "l": "alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6813749", "l": "ALDH1A1 oxidises GA to DGA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23011", "l": "alpha,alpha-trehalose 6-phosphate + H2O <=> D-glucose + D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390835", "l": "DRD1,5 bind DA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56448", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19321", "l": "N,N-dimethylaniline N-oxide = formaldehyde + N-methylaniline", "d": [], "t": []}, {"i": "EC:4.1.2.24", "l": "\"dimethylaniline-N-oxide aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449829", "l": "IL11 binds IL11RA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5444511", "l": "Formation of MSH2:MSH3 Complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57721", "l": "ATP + 4 H(+)(in) + H2O => ADP + 5 H(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047203", "l": "13-hydroxylupinine O-tigloyltransferase activity", "d": ["Catalysis of the reaction: 13-hydroxylupanine + 2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyloxy)lupanine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023173", "l": "Insulin secretory granule docks at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874122", "l": "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41495", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61850", "l": "cholesteryl 3-beta-D-glucoside + H(+) + UDP => cholesterol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43145", "l": "adenosine(22) in tRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyladenosine(22) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26055", "l": "GTP + H(+) + valienol 1-phosphate = diphosphate + GDP-valienol", "d": [], "t": []}, {"i": "EC:2.7.7.91", "l": "\"valienol-1-phosphate guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11431", "l": "beta-D-glucose + O2 <=> D-glucono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204500", "l": "CyP60 chaperones Basigin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19322", "l": "N,N-dimethylaniline N-oxide => formaldehyde + N-methylaniline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43026", "l": "2-aminoprop-2-enoate + a thiol => an S-substituted L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060002", "l": "plus-end directed microfilament motor activity", "d": ["A motor activity that generates movement along a microfilament towards the plus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48632", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49879", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8876472", "l": "NPC2 binds CHOL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177925", "l": "SHC1 binds to the phosphorylated EGF receptor:ligand complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099100", "l": "G-protein gated monoatomic cation channel activity", "d": ["A cation channel activity that is gated by binding of a G-protein beta-gamma dimer."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749253", "l": "Formation of MCM2-7 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54814", "l": "AMP + diphosphate + H(+) + L-isoleucine-(+)-7-isojasmonate => (+)-7-isojasmonate + ATP + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351208", "l": "Spermidine  => N-acetylated spermidine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810843", "l": "Envoplakin binds periplakin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9009910", "l": "IL37(?-218) binds p-S423,S425-SMAD3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52806", "l": "(+)-eremophilene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018613", "l": "9-fluorenone dioxygenase activity", "d": ["Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35485", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine => 5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43631", "l": "L-serine + NAD(+) <=> aminoacetaldehyde + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28876", "l": "H(+)(in) + L-tyrosine(in) => H(+)(out) + L-tyrosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32630", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40195", "l": "(9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9715357", "l": "crizotinib-resistant ALK mutants don't bind crizotinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009282", "l": "CDK1 phosphorylates RUNX2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67692", "l": "ATP + H2O + hexadecanedioate(in) = ADP + H(+) + hexadecanedioate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336417", "l": "DT A:B binds HBEGF and CD9 on the target cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12315", "l": "dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 <=> 2'-hydroxybiphenyl-2-sulfinate + FMN + H(+) + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69015", "l": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655193", "l": "KIAA0101 double monoubiquitination (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654659", "l": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686088", "l": "CASP3 cleaves GSDMD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22840", "l": "D-glutamine + H2O = D-glutamate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.35", "l": "\"D-glutaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24200", "l": "4-aminobenzoate + H(+) = aniline + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22489", "l": "S-(hydroxymethyl)glutathione => formaldehyde + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800794", "l": "PIDD1 associates with CRADD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72986", "l": "dimethylallyl diphosphate + harmol <=> 6-(3-dimethylallyl)harmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14302", "l": "4-pyridoxolactone + H2O => 4-pyridoxate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668395", "l": "CHMP7 binds CC2D1B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875568", "l": "RAPGEF1 activates RAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48042", "l": "a globoside Gb3Cer + N-acetyl-beta-D-galactosamine => a globoside Gb4Cer + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-174367", "l": "GCL ligates L-Glu to L-Cys (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693539", "l": "Ligation of DNA and formation of Holliday structures following repair synthesis (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58622", "l": "decanamide + glyoxylate => N-decanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30230", "l": "dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O <=> dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452122", "l": "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39056", "l": "22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939088", "l": "CR1 gene expression is stimulated by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174368", "l": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26327", "l": "(8Z,11Z)-5-(pentadeca- 8,11,14-trien-1-yl)resorcinol-3-methyl ether + H(+) + S-adenosyl-L-homocysteine => (8Z,11Z)-5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031892", "l": "type 2 vasoactive intestinal polypeptide receptor binding", "d": ["Binding to a type 2 vasoactive intestinal polypeptide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57148", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454081", "l": "RDH5 oxidises 11cROL to 11cRAL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.4", "l": "\"signal-recognition-particle GTPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0140848", "l": "amino acid:monoatomic cation antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + monoatomic cation(in) = solute(in) + monoatomic cation(out). Monoatomic cations include H+, Mg2+, Ca2+, etc."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73944", "l": "dehydrogriseofulvin + H(+) + NADPH => griseofulvin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706393", "l": "RHOBTB3 binds ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27915", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714483", "l": "RAC2 translocates to the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38354", "l": "(R)-3-phenyllactate + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2509838", "l": "ITPA hydrolyses dITP to dIMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63314", "l": "15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79124", "l": "cholate + L-phenylalanine => H2O + L-phenylalanocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15156", "l": "4-hydroxybenzoate + UDP-alpha-D-glucose <=> 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450173", "l": "IRAK1 induces oligomerisation of TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2870221", "l": "E-selectin binds E-selectin ligand (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67809", "l": "L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51714", "l": "keto-D-fructose 6-phosphate => keto-D-tagatose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034785", "l": "salicylate 5-hydroxylase activity", "d": ["Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32735", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42574", "l": "2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2 => 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76285", "l": "guanine(in) + Na(+)(in) => guanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661125", "l": "JMJD6 demethylates Me2sR4-HIST1H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019960", "l": "C-X3-C chemokine binding", "d": ["Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9846332", "l": "FUT1,2 transfer fucose to gangliosides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015476", "l": "hemaglutinin autotransporter activity", "d": ["Enables the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786155", "l": "POLN binds ICL-DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75887", "l": "Conversion of Glycerol to Glycerol-3-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64024", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine) = H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609747", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN3A (GRIN3A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661230", "l": "MT1A binds arsenic (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786421", "l": "CHIA hydrolyses chitin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71756", "l": "2-oxoglutarate(out) + 2-oxoheptanedioate(in) => 2-oxoglutarate(in) + 2-oxoheptanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43076", "l": "erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-416683", "l": "SEMA3E binds to PLXND1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43198", "l": "2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine => adenosine(4) in tRNA(His) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24982", "l": "3-hydroxy-4-methylanthranilyl-5'-AMP + diphosphate => 3-hydroxy-4-methylanthranilate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52098", "l": "9-hydroxy-octadecanoate + H(+) + octadecanoate => 9-octadecanoyloxy-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36200", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604763", "l": "Autocatalytic activation of MMP7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000327", "l": "PLK1 phosphorylates BORA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654651", "l": "Activated FGFR4 binds FRS3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57196", "l": "H2O + S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] = glycolate + H(+) + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29559", "l": "H2O + UDP-alpha-D-glucuronate = 1-phospho-alpha-D-glucuronate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158333", "l": "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16825", "l": "ATP + uridine = ADP + H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.501154301453099", "identifiers": [{"i": "GO:0016638", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.4.-.-", "l": "\"Acting on the CH-NH2 group of donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37477", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29875", "l": "H2O + sn-glycero-3-phospho-L-serine = H(+) + L-serine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13331", "l": "a 3-oxo-Delta(1)-steroid + AH2 => A + a 3-oxosteroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69509", "l": "H2O + N-acetyl-D-glucosamino-1,5-lactone => H(+) + N-acetyl-D-glucosaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63695", "l": "alcohol glucuronate acceptor + UDP-alpha-D-glucuronate <=> a beta-D-glucuronoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202702", "l": "CD177 binds PECAM-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68909", "l": "ATP + H(+) + NADPH + picolinate => AMP + diphosphate + NADP(+) + picolinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60268", "l": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65745", "l": "2-oxoglutarate + decyl sulfate + O2 => CO2 + decanal + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35576", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] => (1'S,5'R)-5'-hydroxyaverantin + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37670", "l": "3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654607", "l": "Activated FGFR2 phosphorylates PPTN11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013452", "l": "RHOD:GTP translocates to the endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78180", "l": "a 1,3-diacylglycerol + an acyl-CoA => a triacylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68653", "l": "2 L-homocysteine => H(+) + hydrogen sulfide + L-homolanthionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4717461", "l": "PIAS1,2-2 SUMOylate PPARG with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34898", "l": "ATP + H2O + selenite(out) <=> ADP + H(+) + phosphate + selenite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690080", "l": "USP3,SAGA deubiquitinate Histone H2A,H2B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9909159", "l": "HK1 phosphorylates Mannose to Man6P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65960", "l": "ATP + H2O + leukotriene C4(out) = ADP + H(+) + leukotriene C4(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78199", "l": "a 3beta-hydroxysteroid + a triacylglycerol = a 1,3-diacylglycerol + a 3beta-hydroxysteroid ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339711", "l": "misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322125", "l": "Defective MMAB does not transfer adenosyl group from ATP to B12s (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9861631", "l": "ME1 tetramerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13041", "l": "L-dopachrome = 5,6-dihydroxyindole-2-carboxylate", "d": [], "t": []}, {"i": "EC:5.3.3.12", "l": "\"L-dopachrome isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-352182", "l": "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018746", "l": "RHOQ binds effectors at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9717841", "l": "holo-FDPS dimer binds NBPs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018756", "l": "RHOH binds GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033858", "l": "N-acetylgalactosamine kinase activity", "d": ["Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59554", "l": "H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone => N,N',N'',N'''-tetraacetylchitotetraose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23541", "l": "ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Glu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696810", "l": "RNase P cleaves the 5' end of pre-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858286", "l": "POU3F2 binds the MITF gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9677585", "l": "CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26022", "l": "beta-D-fructofuranosyl alpha-D-mannopyranoside 6(F)-phosphate + H2O <=> beta-D-fructofuranosyl alpha-D-mannopyranoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5689085", "l": "ATXN3 binds polyUb-PARK2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849094", "l": "ARHGAP35 binds RASA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9853499", "l": "DLD dimer dehydrogenates dihydrolipoyl (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50153", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432590", "l": "Phosphorylated PER is phosphorylated by CK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54685", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (-)-kolavenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73247", "l": "ladanein + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20593", "l": "H2O + N-acetyl-D-glucosamine = acetate + D-glucosamine", "d": [], "t": []}, {"i": "EC:3.5.1.33", "l": "\"N-acetylglucosamine deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430021", "l": "PAN2-PAN3 complex partially deadenylates mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.28", "l": "\"N-acetylmuramoyl-L-alanine amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25555", "l": "9alpha-copalyl diphosphate <=> diphosphate + stemar-13-ene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201669", "l": "Beta-catenin translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390846", "l": "D2D3,4 bind to DA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.674113164858127", "identifiers": [{"i": "GO:0016875", "l": "ligase activity, forming carbon-oxygen bonds", "d": ["Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}, {"i": "EC:6.1.-.-", "l": "\"Forming carbon-oxygen bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45485", "l": "H(+) + pyruvate => acetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77309", "l": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30896", "l": "H2O + O2 + propane-1,3-diamine => 3-aminopropanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18498", "l": "L-ribulose 5-phosphate => L-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53555", "l": "(9S,10R)-epoxy-octadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 18-hydroxy-(9S,10R)-epoxy-octadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418582", "l": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26558", "l": "(3S)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53176", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58372", "l": "(E)-oct-2-en-1-ol + NADP(+) = (2E)-octenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53203", "l": "17beta-hydroxy-5alpha-androstan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta,19-dihydroxy-3-oxo-5alpha-androstanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026531", "l": "p-Y817 of p-5Y-NTRK2 recruits PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62623", "l": "[thioredoxin]-dithiol + a hydroperoxide <=> [thioredoxin]-disulfide + an alcohol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814695", "l": "PERP binds desmosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48779", "l": "O2 + prostaglandin H2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxyprostaglandin H2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141048", "l": "membrane tag activity", "d": ["A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to a lipid, where it acts as a marker for a membrane, recognized by the cellular apparatus to target the tagged protein for some cellular process such as autophagy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6801101", "l": "RABGGTA binds RABGGTB (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23420", "l": "alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.12", "l": "\"trehalose-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52750", "l": "2 isomaltose => alpha-isomaltosyl-(1->3)-isomaltose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46956", "l": "hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] = (E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.1.108", "l": "\"caffeoyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391372", "l": "GNRHR binds GNRH1,2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.40", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110144", "l": "ADP + ADP <=> AMP + ATP [AK2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25913", "l": "A + H2O + quinolin-5-ol => 5-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0031369", "l": "translation initiation factor binding", "d": ["Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928578", "l": "EPH receptors autophosphorylate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53846", "l": "7-oxoglycolithocholate + H(+) + NADH => glycochenodeoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13024", "l": "H(+) + NADH + O2 + vanillate <=> 3,4-dihydroxybenzoate + formaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38004", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H(+) + homogentisate => 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050278", "l": "sedoheptulose-bisphosphatase activity", "d": ["Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66301", "l": "an inositol-1-phosphodihydroceramide + GDP-alpha-D-mannose => an alpha-D-mannosylinositol-1-phosphodihydroceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8853419", "l": "TPX2 promotes AURKA autophosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38319", "l": "chorismate + H2O = (3R,4R)-3,4-dihydroxy-3,4-dihydrobenzoate + pyruvate", "d": [], "t": []}, {"i": "EC:3.3.2.13", "l": "\"chorismatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20320", "l": "L-proline + NADP(+) <=> 1-pyrroline-2-carboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62066", "l": "2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH => 2-deoxy-D-glucose 6-phosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004095", "l": "carnitine O-palmitoyltransferase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49042", "l": "(-)-yatein + H(+) + S-adenosyl-L-homocysteine => (-)-5'-demethylyatein + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9819106", "l": "ULK1 phosphorylates RIPK1 at S357 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11459", "l": "N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-480685", "l": "POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76898", "l": "2-hexyl-5-pentylresorcinol + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hexyl-5-(5-hydroxypentyl)resorcinol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64311", "l": "3-aminobutanoate + pyruvate <=> acetoacetate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9855910", "l": "USF1 is phosphorylated by p-MAPK14 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26066", "l": "4-O-phosphohygromycin B + ADP + H(+) => ATP + hygromycin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427645", "l": "SLC34A3 cotransports Pi, 2Na+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36122", "l": "gibberellin A9 + S-adenosyl-L-methionine <=> O-methyl gibberellin A9 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681375", "l": "KIT binds ripretinib (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69769", "l": "(E)-non-2-enoate + 2 H(+) + NADH => (E)-non-2-enal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44451", "l": "an acyl-CoA + H(+) + malonyl-[ACP] <=> a 3-oxoacyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050358", "l": "tropinone reductase activity", "d": ["Catalysis of the reaction: NADP+ + pseudotropine = H+ + NADPH + tropinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59808", "l": "L-tyrosine = D-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14335", "l": "6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol => an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48458", "l": "2-octanoyl-3-O-beta-D-galactosyl-sn-glycerol + H(+) + octanoate => 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158357", "l": "factor XIIa binds SERPING1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68321", "l": "1D-myo-inositol 2,4,5-triphosphate + H2O => 1D-myo-inositol 2,5-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009702", "l": "L-arabinokinase activity", "d": ["Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090448", "l": "glucosinolate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucosinolate(out) + H+(out) = glucosinolate(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708275", "l": "PDE4A binds PDE4A inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68052", "l": "a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)", "d": [], "t": []}, {"i": "EC:4.6.1.19", "l": "\"ribonuclease T2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632674", "l": "ADRBK1 binds phosphorylated SMO dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25965", "l": "(R)-benzoin + NADP(+) => benzil + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28325", "l": "UDP-alpha-D-glucuronate + wogonin <=> UDP + wogonin 7-O-beta-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45026", "l": "7-dehydrocholesterol + 2 H2O + NADP(+) => cholesterol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-913360", "l": "GM-CSF receptor alpha subunit binds GM-CSF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-379464", "l": "COMT transfers Met to DOPAC to form HVA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662620", "l": "MT3 binds cadmium (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4084912", "l": "Arresten binds integrin alpha1beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39858", "l": "a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycerol <=> a triacyl-sn-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58746", "l": "diphosphate + H(+) + N(7)-methyl-GMP => H2O + N(7)-methyl-GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76426", "l": "N-atom dealkylation of caffeine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692738", "l": "HRH2 binds HRH2 antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41272", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38865", "l": "alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate => phosphate + sucrose 6(F)-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005053", "l": "peroxisome matrix targeting signal-2 binding", "d": ["Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11067", "l": "beta-D-fructose 1,6-bisphosphate + H2O <=> beta-D-fructose 6-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047793", "l": "cycloeucalenol cycloisomerase activity", "d": ["Catalysis of the reaction: cycloeucalenol = obtusifoliol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53416", "l": "8-amino-8-demethylriboflavin + S-adenosyl-L-methionine = 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40002", "l": "a sphingoid 1-phosphate <=> a fatty aldehyde + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55772", "l": "a jasmonate + an L-alpha-amino acid + ATP = a jasmonyl-L-amino acid + AMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.2.52", "l": "\"jasmonoyl--L-amino acid ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130731", "l": "Formation of COPII vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111264", "l": "Addition of nucleotides between position +11 and +30 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029468", "l": "Conversion of PA into DAG by PAP-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27735", "l": "4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75872", "l": "Conversion of malonyl-CoA and acetyl-CoA to palmitate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56615", "l": "L-cysteinyl-[protein] + NAD(+) <=> H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50967", "l": "cytidine(8) in tRNA + H(+) + H2O <=> NH4(+) + uridine(8) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29267", "l": "L-valine(in) + Na(+)(in) = L-valine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032770", "l": "Translocation of YAP1 to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72691", "l": "Formation of the 43S pre-initiation complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20345", "l": "[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.8.1.9", "l": "\"thioredoxin-disulfide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58064", "l": "O2 + reduced [NADPH--hemoprotein reductase] + xanthotoxin = 5-hydroxyxanthotoxin + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62740", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) = 1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62421", "l": "a (R)-2-hydroxy fatty acid + O2 => a fatty acid + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791088", "l": "Expression of GFPT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40837", "l": "2 (9Z)-octadecenoate + 2 H(+) + sn-glycerol 3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75033", "l": "2-(9Z-octadecenoyl)-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 9-hydroxy-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58907", "l": "8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH <=> C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37885", "l": "acetate + oxalyl-CoA => acetyl-CoA + oxalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050436", "l": "microfibril binding", "d": ["Binding to a microfibril, any small fibril occurring in biological material."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44036", "l": "12,13-epoxy-(9Z)-octadecenoate + H2O = 12,13-dihydroxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-877281", "l": "PIAS1 binds p-STAT1 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21884", "l": "H2O + trithionate = H(+) + sulfate + thiosulfate", "d": [], "t": []}, {"i": "EC:3.12.1.1", "l": "\"trithionate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050409", "l": "indolylacetylinositol arabinosyltransferase activity", "d": ["Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-L-arabinose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H+ + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57663", "l": "(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9763200", "l": "BRCA2 mutants do not bind SEM1 (DSS1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16511", "l": "CO2 + formate => H(+) + oxalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77521", "l": "(2R)-2-(furan-2-yl)-2-hydroxyacetonitrile => furfural + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35072", "l": "4-methylphenol(in) => 4-methylphenol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14395", "l": "3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine => N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-173542", "l": "SMURF2 ubiquitinates SMAD2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44666", "l": "a fatty acid + a monoacyl-sn-glycero-3-phosphocholine + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170120", "l": "Translocation of Cdc25B to the cytoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13717", "l": "2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.267", "l": "\"1-deoxy-D-xylulose-5-phosphate reductoisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74389", "l": "formamide(in) => formamide(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77925", "l": "H2O2 + N-(4-aminobutylpyrrolinium) ion + NH4(+) => O2 + sym-homospermidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247843", "l": "secretion of WNT ligands (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18354", "l": "ATP + H2O + K(+)(out) + Na(+)(in) => ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11483", "l": "3-hydroxybenzoate + H(+) + NADPH + O2 <=> 3,4-dihydroxybenzoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029555", "l": "NR1H2,3 binds the ABCG8 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57103", "l": "S-methyl-5-thio-D-ribulose 1-phosphate <=> S-methyl-1-thio-D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23165", "l": "a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose => a flavonol 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71163", "l": "H(+)(in) + L-alanine(out) + Na(+)(out) = H(+)(out) + L-alanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1299480", "l": "Precursor proteins enter TIMM23 PAM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450431", "l": "ZFP36 (TTP) recruits RNA degradation activities (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50835", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 <=> 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451310", "l": "Activation of Edited Kainate receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853774", "l": "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69851", "l": "a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.47", "l": "\"gingipain K\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46185", "l": "3-methylbutanoate + ATP + CoA => 3-methylbutanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382061", "l": "Extracellular processing of novel PDGFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51297", "l": "a quinone + H2O + L-methionyl-[protein] => a quinol + L-methionyl-(R)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-451418", "l": "Pellino ubiquitinates IRAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450074", "l": "Interleukin-3 receptor alpha subunit binds Interleukin-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75003", "l": "ATP + CoA + sulfoacetate = AMP + diphosphate + sulfoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31259", "l": "but-3-ynal + H2O + NAD(+) = 3-butynoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39241", "l": "NADP(+) + triacontanoyl-CoA => (2E)-triacontenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11010", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate => a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41104", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46501", "l": "2-oxoglutarate + O2 + UMP => CO2 + phosphate + succinate + uridine-5'-aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751039", "l": "Inactive G alpha (12/13) reassociates with G beta:gamma (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62663", "l": "2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol <=> (2'R)-atrovenetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49491", "l": "GDP-4-dehydro-alpha-D-rhamnose + L-glutamate <=> 2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.37", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72480", "l": "citrate(out) + trans-aconitate(in) => citrate(in) + trans-aconitate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78036", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol => a 1,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49621", "l": "D-erythritol 1-phosphate + NADP(+) => D-erythrulose 1-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990955", "l": "G-rich single-stranded DNA binding", "d": ["Binding to G-rich, single-stranded DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686930", "l": "RIPK3 is cleaved by CASP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65242", "l": "(11Z)-octadecenoate + CoA + H(+) => (11Z)-octadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202291", "l": "Activation of Lck (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50526", "l": "CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] => acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56519", "l": "Fe-coproporphyrin III + 2 H(+) + 2 H2O2 <=> 2 CO2 + 4 H2O + heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58961", "l": "benzaldehyde + H2O + O2 => benzoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019776", "l": "Atg8-family ligase activity", "d": ["Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 family modifier to phosphatidylethanolamine or phosphatidylserine on a membrane."], "t": []}, {"i": "REACT:R-HSA-5681981", "l": "ATG3 transfers LC3 from ATG7 to ATG3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855158", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22978", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111930", "l": "Adenylate cyclase produces cAMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63359", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 <=> (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74047", "l": "L-alanine(in) + L-valine(out) = L-alanine(out) + L-valine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140842", "l": "RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 5)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110237", "l": "MUTYH mediated recognition and binding of an adenine opposite to an 8-oxoguanine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6788999", "l": "HV1-mediated H+ transfer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50654", "l": "2-(2-methylsulfanyl)propylmaleate + H2O => 2-(3-methylsulfanyl)propylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374919", "l": "Noradrenaline clearance from the synaptic cleft (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-606326", "l": "HJURP:CENPA complex localizes to the centromere (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0008907", "l": "integrase activity", "d": ["Catalysis of the integration of one DNA segment into another."], "t": []}, {"i": "REACT:R-HSA-164523", "l": "Transesterification to connect viral DNA 3' ends to host DNA 5' ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201631", "l": "Caspase-mediated cleavage of Desmoglein 3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912401", "l": "NOTCH4 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018747", "l": "RHOQ GEFs activate RHOQ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64113", "l": "an N-acyl-L-phenylalanine + H2O => a fatty acid + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981931", "l": "RAC1 and CDC42 activate PAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0001791", "l": "IgM binding", "d": ["Binding to an immunoglobulin of the IgM isotype."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352136", "l": "SLC38A4 (ATA3)-mediated uptake of arginine and lysine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64381", "l": "3 A + phytyl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796058", "l": "AcK-NFE2L2 binds the TXN gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45920", "l": "16-hydroxyhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(17-hydroxy-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70582", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31535", "l": "2-oxoglutarate + L-arginine + O2 = CO2 + guanidine + L-glutamate 5-semialdehyde + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.7", "l": "\"2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046316", "l": "gluconokinase activity", "d": ["Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18894", "l": "a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose => a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198813", "l": "GSTO dimers reduce DeHA to AscH- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24799", "l": "(S)-2-amino-6-oxoheptanedioate => (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9012657", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399978", "l": "Protein kinase C, alpha type phosphorylates MARCKS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17825", "l": "ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28367", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate => beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102815", "l": "caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity", "d": ["Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + caffeoyl-CoA = delphinidin 3-O-glucosyl-5-O-caffeoylglucoside + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703440", "l": "FLT3 fusions:GRB2 bind GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26006", "l": "di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate = beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102793", "l": "soyasapogenol B glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate + soyasapogenol B = H+ + UDP + soyasapogenol B 3-O-beta-glucuronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18691", "l": "a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851919", "l": "Activated MET binds GAB1 and GRB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035049", "l": "juvenile hormone acid methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to juvenile hormone acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38973", "l": "(2E)-octadecenoyl-CoA + H2O2 => O2 + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29325", "l": "fumarate(out) + succinate(in) => fumarate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39070", "l": "3-oxooctanedioyl-CoA + CoA <=> acetyl-CoA + hexanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.236", "l": "\"NAD(+) 3'-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60057", "l": "a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + H(+) + NADH + O2 => a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29594", "l": "2-hydroxyethane-1-sulfonate + NADP(+) <=> H(+) + NADPH + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452102", "l": "p-STAT5 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199154", "l": "CD200 binds to CD200R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78208", "l": "D-methionine + H2O + O2 => 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50660", "l": "3-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034832", "l": "geranial dehydrogenase activity", "d": ["Catalysis of the reaction: geranial + NAD+ + OH- = geranylate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109701", "l": "PDPK1 binds PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39960", "l": "1-hexadecanoylglycerol + H2O => glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65715", "l": "alpha-D-glucose 1-phosphate + GDP-beta-L-galactose <=> beta-L-galactose 1-phosphate + GDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004577", "l": "N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080118", "l": "brassinosteroid sulfotransferase activity", "d": ["Catalysis of the reaction: a brassinosteroid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated brassinosteroid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a brassinosteroid acceptor, producing the sulfated brassinosteroid derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102499", "l": "SHG alpha-glucan phosphorylase activity", "d": ["Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950782", "l": "p-STAT1 binds p-STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879674", "l": "CD97 binds CD55 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78379", "l": "L-cysteinyl-[protein] + S-nitroso-CoA = CoA + S-nitroso-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61620", "l": "[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose = [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.374", "l": "\"beta-1,2-mannooligosaccharide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62819", "l": "4 monapinone E + O2 <=> 2 dinapinone E + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036192", "l": "3-hydroxyindolin-2-one monooxygenase activity", "d": ["Catalysis of the reaction: 3-hydroxyindolin-2-one + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2509827", "l": "ITPA hydrolyses ITP to IMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48097", "l": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine => 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38370", "l": "8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA <=> 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42516", "l": "H2O + L-gulono-1,4-lactone = H(+) + L-gulonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682967", "l": "WHSC1 binds DNA DSBs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16914", "l": "a CDP-1,2-diacyl-sn-glycerol + L-serine => a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047894", "l": "flavonol 3-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H+ + quercetin 3-sulfate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58279", "l": "6 ATP <=> cyclic hexaadenylate + 6 diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37351", "l": "cytidine 2'-phosphate + H2O = cytidine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55585", "l": "an adenosine in mRNA + S-adenosyl-L-methionine => an N(6)-methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78656", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + silphinene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050507", "l": "indoxyl-UDPG glucosyltransferase activity", "d": ["Catalysis of the reaction: indoxyl + UDP-D-glucose = H+ + indican + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18383", "l": "dihydroxyacetone phosphate + pyruvate => dihydroxyacetone + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57494", "l": "2-methylcitrate + CoA + H(+) => H2O + oxaloacetate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9008052", "l": "IL1F10(?-152) binds IL1RAPL1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34678", "l": "CTP + N,N-diacetyllegionaminate <=> CMP-N,N-diacetyllegionaminate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199935", "l": "MSK1 activates CREB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69927", "l": "adenosine(out) + Na(+)(out) = adenosine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62098", "l": "2-(9Z-octadecenoyl)-glycerol + phosphate => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190168", "l": "HMBL spontaneously transforms to URO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626928", "l": "CREBBP binds FOXO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508308", "l": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9839379", "l": "TGFBR3 binding to FGF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805205", "l": "GPR35 binds kynurenic acid (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65126", "l": "benzyl acetate + CoA => benzoyl-CoA + ethanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.10.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37330", "l": "ATP + H2O + L-methionyl-L-alanine(out) <=> ADP + H(+) + L-methionyl-L-alanine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53288", "l": "3-dehydro-scyllo-inosose + H2O = 5-dehydro-L-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664871", "l": "NBR1 translocates from cytosol to perixosomal membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951486", "l": "CD46 binds C4b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676597", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58534", "l": "akuammicine + formate + H(+) => 15alpha-stemmadenine intermediate I + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2176503", "l": "Degradation of SMAD2/3:SMAD4 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839390", "l": "TGFBR3 complex binds to TGFBR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373075", "l": "Metabotropic glutamate receptors bind glutamate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26195", "l": "(S)-malyl-CoA + ADP + phosphate => (S)-malate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350440", "l": "FT binds to DS in an adjacent cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853789", "l": "GDNF,NRTN bind RET:GFRA1,GFRA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34844", "l": "7,8-dihydromonapterin 3'-triphosphate + 3 H2O => 7,8-dihydromonapterin + 2 H(+) + 3 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694410", "l": "TMED2:TMED10 tetramer binds GPI anchored proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944215", "l": "Association of procollagen type XX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77213", "l": "3alpha-sulfotaurodeoxycholate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + taurodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32879", "l": "(1R,4R,5R)-5-hydroxycamphor + NAD(+) = (1R,4R)-bornane-2,5-dione + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.327", "l": "\"5-exo-hydroxycamphor dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54589", "l": "S-adenosyl-L-methionine + uridine in 25S rRNA => H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51817", "l": "ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) => AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.35", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149519", "l": "MMACHC decyanates CNCbl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50875", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 <=> (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35566", "l": "H2O + N-(9Z-hexadecenoyl) ethanolamine <=> (9Z)-hexadecenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64675", "l": "2-(methylsulfanyl)acetyl-CoA + butan-1-ol <=> butyl 2-(methylsulfanyl)acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062240", "l": "euchromatin-nuclear membrane anchor activity", "d": ["Binding to euchromatin and the nuclear inner membrane, in order to establish and maintain the euchromatin location and organization."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66140", "l": "acetyl-CoA + octopamine = CoA + H(+) + N-acetyloctopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28090", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.33", "l": "\"UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1226094", "l": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987033", "l": "p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19129", "l": "ATP + thymidine = ADP + dTMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39118", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NAD(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36710", "l": "O-ureido-L-serine <=> O-ureido-D-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25903", "l": "D-arabino-hex-3-ulose 6-phosphate <=> beta-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5688797", "l": "ATXN3 family cleave Ub chains (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.87", "l": "\"ADAMTS13 endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482772", "l": "Release of platelet cytosolic components (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46085", "l": "H2O + sn-glycerol 1-phosphate => glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73857", "l": "5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP => 5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19415", "l": "AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe) => ATP + L-phenylalanine + tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362486", "l": "TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74358", "l": "a cytidine in mRNA + H(+) + H2O <=> a uridine in mRNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36899", "l": "guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.228", "l": "\"tRNA (guanine(37)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35430", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + cyanidin 3-O-beta-D-glucoside <=> (E)-sinapate + cyanidin 3,5-di-O-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27700", "l": "beta-L-galactose 1-phosphate + GDP + H(+) => GDP-beta-L-galactose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16717", "l": "deoxycholate + FAD + H(+) + H2O = cholate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708275", "l": "PDE4A binds PDE4A inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004574", "l": "oligo-1,6-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265456", "l": "NPC1L1 binds ezetimibe (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58022", "l": "eupatolide + H2O => 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22928", "l": "4-acetamidobutanoyl-CoA + H2O = 4-aminobutanoyl-CoA + acetate", "d": [], "t": []}, {"i": "EC:3.5.1.51", "l": "\"4-acetamidobutyryl-CoA deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38424", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9603784", "l": "PEX19:class I PMP binds PEX3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76052", "l": "Binding of TFIIIA To type 1 Promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102194", "l": "protein-fructosamine 3-kinase activity", "d": ["Catalysis of the reaction: ATP + a [protein]-N6-D-fructosyl-L-lysine = ADP + H+ + a [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982017", "l": "Active G alpha (q) binds RGS proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63453", "l": "3-[(R)-glyceryl]-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin => GMP + H(+) + oxidized 3PG-factor420-0", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18545", "l": "2-dehydro-3-deoxy-L-arabinonate = glycolaldehyde + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.2.18", "l": "\"2-dehydro-3-deoxy-L-pentonate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863727", "l": "STON2 is neddylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944223", "l": "Association of procollagen type V (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37429", "l": "a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55336", "l": "a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine = a 3',5'-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012761", "l": "The p75NTR:NgR:MDGI binds RHOA-GDI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351871", "l": "Caspase-mediated cleavage of Z0-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43114", "l": "H(+) + NADH + phenylglyoxylate => (R)-mandelate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49498", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane => 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0120296", "l": "peptide dopaminyltransferase activity", "d": ["Catalysis of the reaction: dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+)."], "t": []}, {"i": "RHEA:66556", "l": "dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696323", "l": "CNRs bind CNR agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43700", "l": "(2E,6E)-farnesoate + S-adenosyl-L-methionine = methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033431", "l": "CGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CGA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5626228", "l": "The distal appendage proteins recruit TTBK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159796", "l": "Furin cleaves pro-factor IX to factor IX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29651", "l": "agmatine(in) + L-arginine(out) = agmatine(out) + L-arginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9714691", "l": "RAC3 binds ER effectors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43268", "l": "a ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673349", "l": "WNT5 binds FZD7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190520", "l": "Association of Golgi  transport vesicles with microtubules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47675", "l": "H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551648", "l": "SUMOylation of TDG with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022061", "l": "Dermatan sulfate can be further sulfated on position 2 of iduronate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9835385", "l": "DUS2 binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-419002", "l": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033527", "l": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42245", "l": "H(+) + malonyl-[ACP] + propanoyl-CoA => 3-oxopentanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351894", "l": "Caspase mediated cleavage of BAP31 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353023", "l": "3-phosphoglycerate + ATP <=> 1,3-bisphosphoglycerate + ADP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696947", "l": "USP47 deubiquitinates POLB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0042085", "l": "5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.4", "l": "\"thymidine phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69930", "l": "adenosine(out) + Na(+)(out) <=> adenosine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9635446", "l": "Rv3654c binds SFPQ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53349", "l": "5,6-dihydrouridine(20a) in tRNA + NAD(+) => H(+) + NADH + uridine(20a) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444433", "l": "Cho transports from the extracellular space to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17298", "l": "2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] => CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691174", "l": "RAC1 binds effectors at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64901", "l": "H2O + UTP => H(+) + phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50257", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174273", "l": "Translocation of Cyclin A:Cdk2 complexes to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46716", "l": "pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802925", "l": "Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0015562", "l": "efflux transmembrane transporter activity", "d": ["Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35704", "l": "1'-hydroxyversicolorone + H(+) + NADPH + O2 => (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1474146", "l": "GCH1 reduces GTP to dihydroneopterin triphosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78558", "l": "Cs(+)(in) <=> Cs(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004070", "l": "aspartate carbamoyltransferase activity", "d": ["Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5444511", "l": "Formation of MSH2:MSH3 Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008921", "l": "lipopolysaccharide-1,6-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71042", "l": "L-methionine(in) + L-phenylalanine(out) <=> L-methionine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34130", "l": "(2E)-geranyl diphosphate + olivetolate <=> cannabigerolate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14820", "l": "4-maleylacetoacetate <=> 4-fumarylacetoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9620456", "l": "sGC stimulators bind sGC:NO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034901", "l": "endosulfan hydroxyether dehydrogenase activity", "d": ["Catalysis of the reaction: endosulfan hydroxyether = endosulfan lactone + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56282", "l": "AMP + L-prolyl-[peptidyl-carrier protein] => 3'-L-prolyl-AMP + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55692", "l": "an inositol-1-phosphoceramide + H2O = 1D-myo-inositol 1-phosphate + an N-acyl-sphingoid base + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047773", "l": "carnitinamidase activity", "d": ["Catalysis of the reaction: (R)-carnitinamide + H2O = (R)-carnitine + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59228", "l": "6-sulfo-alpha-D-quinovose = 6-sulfo-beta-D-quinovose", "d": [], "t": []}, {"i": "EC:5.1.3.43", "l": "\"sulfoquinovose mutarotase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71682", "l": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015518", "l": "arabinose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854466", "l": "VLDLR binds RELN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9676071", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112042", "l": "Opioid binds MOR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9842656", "l": "ALK binds ALKAL ligand (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0004607", "l": "phosphatidylcholine-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9749971", "l": "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16949", "l": "myo-inositol + NAD(+) = H(+) + NADH + scyllo-inosose", "d": [], "t": []}, {"i": "EC:1.1.1.18", "l": "\"inositol 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57763", "l": "2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH <=> C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50101", "l": "dodecanoyl-CoA + taurine => CoA + H(+) + N-dodecanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77076", "l": "(1R,4R,5S)-acoradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane carbocation + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173739", "l": "Spontaneous hydrolysis of C3 thioester (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192036", "l": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32122", "l": "GDP-valienol + validamine 7-phosphate <=> GDP + H(+) + validoxylamine A 7'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682020", "l": "MRN complex binds shortened telomeres (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34369", "l": "acrylate + NH4(+) => acrylamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31403", "l": "all-trans-4,4'-diapo-zeta-carotene + FAD + H(+) = all-trans-4,4'-diaponeurosporene + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047656", "l": "alpha,alpha-trehalose phosphorylase activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388831", "l": "Phosphorylation of CD28 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318576", "l": "Defective MMACHC does not reduce Cbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351201", "l": "N-acetylated spermidine (cytosol)=>N-acetylated spermidine (peroxisomal) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733292", "l": "AMY1-3 bind pramlintide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140999", "l": "histone H3K4 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421517", "l": "Transport of delta-aminolevulinate from the mitochondrial matrix to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24169", "l": "3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate => 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803890", "l": "SFN dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74258", "l": "XDH oxidizes xanthine to form urate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602466", "l": "Activation of MT-MMPs by FURIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191763", "l": "snRNP:Snurportin complex formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50031", "l": "H2O + tetradecanoyl-CoA <=> adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21197", "l": "5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine => L-methionine + tetrahydropteroyltri-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.1.3", "l": "\"ferredoxin--NAD(+) reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352059", "l": "SLC6A15-mediated amino acid uptake (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-374664", "l": "Phosphorylation and activation of Ezrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46565", "l": "acetyl-CoA + apo-[ACP] => acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0010354", "l": "homogentisate prenyltransferase activity", "d": ["Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730858", "l": "Autophosphorylation of BTK/ITK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190245", "l": "FGFR1b binds to FGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13096", "l": "an N-acylsphing-4-enine + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70589", "l": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43970", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73792", "l": "dimethylallyl diphosphate + neoechinulin A => diphosphate + variecolorin G", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661217", "l": "MT1A binds zinc (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52025", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 => 18S-resolvin E2 + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634702", "l": "LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33897", "l": "H(+) + NADH + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose => NAD(+) + trans,octa-cis-decaprenylphospho-beta-D-arabinofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809764", "l": "SBF1 binds MTMR2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9647746", "l": "EML4 trimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801762", "l": "REG3A oligomerize to form a pore complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0036137", "l": "kynurenine aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from kynurenine to an acceptor, usually a 2-oxo acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50822", "l": "H(+) + NADPH + testosterone => 17beta-hydroxy-5alpha-androstan-3-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44914", "l": "(3E)-hexenoyl-CoA + NADP(+) => (2E,4E)-hexadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088264", "l": "Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32184", "l": "cholesterol + O2 => cholest-5-en-3-one + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16782", "l": "a fatty acyl-CoA + H2O => a fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25240", "l": "ATP + CDP <=> ADP + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29566", "l": "ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16896", "l": "pyridine + S-adenosyl-L-methionine <=> N-methylpyridinium + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19217", "l": "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)", "d": [], "t": []}, {"i": "EC:4.5.1.1", "l": "\"DDT-dehydrochlorinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11656", "l": "ATP + holo-[peptidyl-carrier protein] + L-proline = AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]", "d": [], "t": []}, {"i": "EC:6.2.1.53", "l": "\"L-proline--[L-prolyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74183", "l": "S-adenosyl-L-methionine + taxifolin = H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657599", "l": "Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917987", "l": "TFRC dimer binds 2xholoTF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0008988", "l": "rRNA (adenine-N6-)-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61693", "l": "holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP => AMP + L-threonyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15673", "l": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.11", "l": "\"acetoacetyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250264", "l": "TXNIP binds reduced thioredoxin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.178", "l": "\"steroid 22S-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228840", "l": "Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043890", "l": "N-acetylgalactosamine-6-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1006143", "l": "CD46 binds C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50293", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-3,4-didehydroretinol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24410", "l": "inosine + NH4(+) => adenosine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36981", "l": "3-oxo-(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + CO2 + CoA => (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32481", "l": "3,5-diiodo-L-tyrosine + H(+) + 2 NADPH => 2 iodide + L-tyrosine + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36582", "l": "dTDP-alpha-D-fucose + NAD(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834807", "l": "ILF3 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549467", "l": "Expression of CRYPTOCHROME-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39739", "l": "3-hydroxydodecanoate + H(+) + NADPH + O2 = 3,12-dihydroxydodecanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071890", "l": "bicarbonate binding", "d": ["Binding to bicarbonate ions (CHO3-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57030", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+) => FADH2 + N-methylnicotinate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68882", "l": "AMP + diphosphate + NADP(+) + salicylaldehyde => ATP + H(+) + NADPH + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031886", "l": "type 1 member 3 taste receptor binding", "d": ["Binding to a type 1 member 3 taste receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74581", "l": "N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein] => H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13348", "l": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] <=> diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70271", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1222376", "l": "NOX2 generates superoxide from oxygen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692764", "l": "MAPK6 binds CCND3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64983", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy-8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39665", "l": "a quinone + reduced coenzyme F420-(gamma-L-Glu)(n) => a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42095", "l": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] <=> all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31350", "l": "(+)-abscisic acid D-glucopyranosyl ester + H2O <=> 2-cis-(+)-abscisate + beta-D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35855", "l": "1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38010", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine <=> 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514891", "l": "SLC24A1 exchanges 4Na+ for Ca2+, K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20675", "l": "4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH => 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78882", "l": "a short-chain (3R)-hydroxy fatty acyl-CoA + NAD(+) <=> a short-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693148", "l": "BCKDK phosphorylates BCKDH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21016", "l": "H2O + L-asparagine = L-aspartate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371554", "l": "HSF1 acetylation at Lys80 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027373", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PLCgamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449811", "l": "IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64888", "l": "ATP + holo-[ACP] + tetradecanoate = AMP + diphosphate + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066785", "l": "Retranslocation of DHA back to ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57773", "l": "3-nitrotoluene + NADH + O2 => 4-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25803", "l": "H2O + N(1)-acetylspermine + O2 <=> 3-acetamidopropanal + H2O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12740", "l": "5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine <=> [PrdC protein]-L-selenocysteine/L-cysteine + D-proline", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9909159", "l": "HK1 phosphorylates Mannose to Man6P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080061", "l": "indole-3-acetonitrile nitrilase activity", "d": ["Catalysis of the reaction: indole-3-acetonitrile + 2 H2O = indole-3-acetic acid + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48649", "l": "lipoxin A4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-lipoxin A4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56532", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine phosphate = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23866", "l": "2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP => 4-CDP-2-C-methyl-D-erythritol 2-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63934", "l": "abscisate(out) + ADP + H(+) + phosphate => abscisate(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73086", "l": "chrysoeriol + S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine + velutin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730842", "l": "PI3K associates with phosphorylated GAB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3318486", "l": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37304", "l": "ATP + glycyl-L-asparagine(out) + H2O => ADP + glycyl-L-asparagine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15316", "l": "ethanolamine <=> acetaldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.3.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004477", "l": "methenyltetrahydrofolate cyclohydrolase activity", "d": ["Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69142", "l": "Recruitment of Dna2 endonuclease (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52333", "l": "2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] => 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78634", "l": "hexacosanoyl-CoA + O2 <=> (2E)-hexacosenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62694", "l": "2 H(+) + 2 H2O + 2 tellimagrandin II => 2 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140696", "l": "(S)-2-hydroxyglutarate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703432", "l": "p-STAT5 dissociates from FLT3 fusion proteinsp- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10713", "l": "L-phenylalanine + O2 => 2-phenylacetamide + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20903", "l": "H(+) + H2O + N-benzyloxycarbonylglycine <=> benzyl alcohol + CO2 + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3209179", "l": "ERF inhibits ETS2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56687", "l": "dihydrorhizobitoxine + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + rhizobitoxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018608", "l": "1-indanone dioxygenase activity", "d": ["Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624120", "l": "CEBPA binds CDK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43200", "l": "cytidine(1920) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1920) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.226", "l": "\"23S rRNA (cytidine(1920)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35967", "l": "fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.119", "l": "\"fumitremorgin C monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31010", "l": "(S)-2,3-epoxysqualene <=> beta-amyrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68033", "l": "(S)-cystathionine ketimine + 2 H(+) + NADH => (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10382", "l": "5-phospho-alpha-D-ribose 1-diphosphate + orotate => diphosphate + orotidine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34083", "l": "a (3R)-3-hydroxyacyl-CoA = a (3S)-3-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42882", "l": "H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine => S-adenosyl 3-(methylsulfanyl)propylamine + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726509", "l": "NR3C2 binds fludrocortisone (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46953", "l": "2 formate + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 CO2 + H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380303", "l": "Dissociation of Phospho-Nlp from the centrosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20455", "l": "H(+) + scopolin + UDP => scopoletin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22367", "l": "L-quinate + NAD(+) <=> 3-dehydroquinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78867", "l": "a medium-chain (3R)-hydroxyacyl-CoA = a medium-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71286", "l": "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22342", "l": "3-hydroxybenzaldehyde + H(+) + NADPH => 3-hydroxybenzyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27566", "l": "(2E)-geranyl diphosphate + 7 isopentenyl diphosphate <=> all-trans-nonaprenyl diphosphate + 7 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228521", "l": "PIAS1,4 SUMOylate CASP8AP2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24238", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + trimethylamine N-oxide => 2 Fe(III)-[cytochrome c] + H2O + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685830", "l": "TUBB binds colchicine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797245", "l": "Expression of FASLG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48645", "l": "prostaglandin H2 => (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23229", "l": "L-lysine + NADPH + O2 => H2O + N(6)-hydroxy-L-lysine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.3.2", "l": "\"NAD(P)H oxidase (H2O-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31756", "l": "2-oxepin-2(3H)-ylideneacetyl-CoA + H2O => 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "61.295603641503597", "identifiers": [{"i": "GO:0004672", "l": "protein kinase activity", "d": ["Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295621", "l": "CBL dissociates from ubiquitinated p-SPRY2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210300", "l": "Interaction of DAP12 and TREM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23555", "l": "2-methylpropane-1,2-diol + NAD(+) <=> 2-hydroxy-2-methylpropanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791327", "l": "TP53 binds the BCL2L14 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.6.2.-", "l": "\"Linked to the hydrolysis of a nucleoside triphosphate\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0005294", "l": "neutral L-amino acid secondary active transmembrane transporter activity", "d": ["Enables the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-205136", "l": "GTP-bound RAC contributes to JNK activation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690759", "l": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781840", "l": "ERCC6 binds stalled RNA Pol II (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694576", "l": "nsp3 binds to nsp7-8 and nsp12-16 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085296", "l": "SUMOylation of NCOA1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2464809", "l": "RBP3 regulates the transport of atROL from ROS to RPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607737", "l": "BCL10 oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696605", "l": "USP12, USP26 deubiquitinate AR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786190", "l": "CMBL hydrolyses OM to OLMS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803917", "l": "TP53 stimulates RGCC expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9824888", "l": "OPTN, TBK1 bind ubiquitinated MOM proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20953", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose => beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109823", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49274", "l": "calcitriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => alfacalcidol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50748", "l": "H2O + juglone = naphthalene-1,2,4,8-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18846", "l": "(R)-glycerate + NAD(+) => 2-hydroxy-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050135", "l": "NADP+ nucleosidase activity", "d": ["Catalysis of the reaction: NADP+ + H2O = ADP-D-ribose-2-phosphate + nicotinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25563", "l": "9alpha-copalyl diphosphate <=> 9beta-pimara-7,15-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58351", "l": "2 2-oxoglutarate + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 O2 <=> 2 CO2 + 2 formaldehyde + L-arginyl-[protein] + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731590", "l": "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17595", "l": "2-oxoglutaramate + L-phenylalanine => 3-phenylpyruvate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55860", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45148", "l": "3-(methylsulfanyl)acryloyl-CoA + H2O = 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023348", "l": "MECP2 binds DLL1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74742", "l": "Phosphorylation of SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53714", "l": "beta-hematin => 2 Fe(III)-heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58533", "l": "15alpha-stemmadenine intermediate I + H2O => akuammicine + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38776", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9837333", "l": "SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68073", "l": "Delta(2)-thiazoline-2-carboxylate + 2 H(+) + NADPH => L-thiazolidine-2-carboxylate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28569", "l": "3 2,3-dihydroxybenzoyl-5'-AMP + 3 L-seryl-5'-AMP <=> 6 AMP + enterobactin + 7 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53724", "l": "ATP + N-acetyl-D-glucosamine = ADP + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56929", "l": "abieta-7,13-dien-18-al + O2 + reduced [NADPH--hemoprotein reductase] => abieta-7,13-dien-18-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54849", "l": "H(+) + hexan-3-one + NADPH + O2 => H2O + NADP(+) + propyl propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59251", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + (E)-4-coumaroyl-CoA <=> (E)-4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19340", "l": "2 hydroxylamine + 2 NAD(+) <=> 2 H(+) + hyponitrous acid + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444731", "l": "GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28399", "l": "H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate => L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15514", "l": "ATP + keto-D-tagatose => ADP + H(+) + keto-D-tagatose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450348", "l": "Activated human JNKs migrate to nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080100", "l": "L-glutamine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-glutamine + 2-oxoglutarate = 2-oxoglutaramate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086083", "l": "SUMOylation of ING2 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3371582", "l": "HSBP1 binds HSF1 trimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167419", "l": "The receptor:G-protein complex releases GDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54501", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate => beta-geranylfarnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66787", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out) <=> 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621385", "l": "EGR1 binds TRIB1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76549", "l": "CoA + H(+) + N-acetyl-D-glutamine => acetyl-CoA + D-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61651", "l": "ATP + holo-[ACP] + salicylate <=> AMP + diphosphate + salicyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9671145", "l": "DKC1 binds SHQ1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197250", "l": "NAMPT transfers PRIB to NAM to form NAMN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.86", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50139", "l": "ethyl (9Z)-octadecenoate + H2O <=> (9Z)-octadecenoate + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031858", "l": "pituitary adenylate cyclase-activating polypeptide receptor binding", "d": ["Binding to a pituitary adenylate cyclase-activating polypeptide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69190", "l": "ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[protein] + phosphate => ATP + gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.65", "l": "\"sugiol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20650", "l": "23,24-dihydrocucurbitacin B + NADP(+) => cucurbitacin B + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390329", "l": "Dephosphorylation of AKT by PP2A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38115", "l": "(9Z)-octadecenoyl-CoA + 1-dodecanoylglycerol = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62067", "l": "2-deoxy-D-glucose 6-phosphate + NAD(+) <=> 2-deoxy-6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418581", "l": "Activated P2Y purinoceptor 1 binds G-protein Gq (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809810", "l": "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202144", "l": "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2684507", "l": "Syndecans 1, 2, 4, (3) bind FGF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69950", "l": "3-dehydro-6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33628", "l": "ATP + CoA + decanoate => AMP + decanoyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41638", "l": "1-O-(1Z-alkenyl)-sn-glycerol + phosphate => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362437", "l": "C-terminal Hh fragments are bound by lectins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78510", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64413", "l": "n H(+)(out) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out) => n H(+)(in) + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37783", "l": "(9Z)-octadecenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188985", "l": "trehalose + H2O => 2 D-glucose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10942", "l": "(4R)-limonene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950453", "l": "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8951499", "l": "Loading of antigenic peptides on to class I MHC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102066", "l": "alpha-patchoulene synthase activityy", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphoric acid + alpha-patchoulene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1606602", "l": "ASAH1 hydrolyzes ceramide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691174", "l": "RAC1 binds effectors at the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61374", "l": "4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate => 4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37726", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216058", "l": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420206", "l": "Phosphorylation of SRC-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682992", "l": "KDM4A,B bind H4K20Me2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38701", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34143", "l": "cannabinerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442345", "l": "hZIP10 mediates zinc influx into cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.6", "l": "\"DNA-directed RNA polymerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62552", "l": "beta-D-glucosylceramide + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102937", "l": "16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 16-alpha-hydroxygypsogenate = 16-alpha-hydroxygypsogenate-28-beta-D-glucoside + UDP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49359", "l": "2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54521", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => cycloaraneosene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641253", "l": "ZNRF3 ubiquitinates FZD to promote its downregulation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9651467", "l": "SERPING1 variant does not bind kallikrein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8944233", "l": "Association of procollagen type XIX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45915", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH <=> a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53095", "l": "2-hydroxy-17beta-estradiol + S-adenosyl-L-methionine <=> 2-hydroxy-3-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19122", "l": "an S-substituted glutathione(in) + ATP + H2O => ADP + an S-substituted glutathione(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0008296", "l": "3'-5'-DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule."], "t": []}, {"i": "REACT:R-HSA-9023943", "l": "MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "75.045601261176557", "identifiers": [{"i": "GO:0098631", "l": "cell adhesion mediator activity", "d": ["The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1236943", "l": "Loading of antigen peptide onto MHC class I molecule (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9860264", "l": "TASL is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28715", "l": "(R)-malate(in) + 2 H(+)(in) = (R)-malate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952289", "l": "FAM20C phosphorylates FAM20C substrates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654544", "l": "Ligand-independent dimerization of overexpressed FGFR1c (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696358", "l": "TREM,CD300 binds lipids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24491", "l": "H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] <=> (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416690", "l": "SEMA4A binds to PLXND1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061664", "l": "Pup ligase activity", "d": ["Catalysis of the transfer of Pup to a substrate protein via the reaction X-Pup + S = X + S-Pup, where X is either an E2 or E3 enzyme, the X-Pup linkage is a thioester bond, and the S-Pup linkage is an isopeptide bond between the C-terminal amino acid of Pup and the epsilon-amino group of lysine residues in the substrate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9691421", "l": "BTK binds BTK inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78311", "l": "dAMP + dATP = 2 dADP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66043", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46825", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 => 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41129", "l": "1-dodecanoyl-sn-glycerol + H(+) + phosphocholine => 1-dodecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24805", "l": "(2S)-2-acetolactate + thiamine diphosphate = 2-(1-hydroxyethyl)thiamine diphosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10481", "l": "2-oxoglutarate + 4-hydroxy-L-glutamate => 4-hydroxy-2-oxoglutarate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396370", "l": "VTN binds collagens II, III and V (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12660", "l": "a (2S)-2-methylacyl-CoA <=> a (2R)-2-methylacyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11978", "l": "5a,11a-dehydrotetracycline + H2O + NADP(+) => anhydrotetracycline + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022398", "l": "ACE:Zn2+ hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-156930", "l": "GTP-binding activates eEF2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445064", "l": "Activation of Rac1 by VAV2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831034", "l": "Expression of PAX2 in metanephric mesenchyme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30272", "l": "2 (3,4-dimethoxyphenyl)methanol + H2O2 => 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74986", "l": "Elongation of pre-rRNA transcript (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8957241", "l": "TP73 tetramer translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8856945", "l": "PP2A methylation by LCMT1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66817", "l": "2 Na(+)(in) + tetrahydroxoborate(in) => 2 Na(+)(out) + tetrahydroxoborate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847537", "l": "RAB43:GTP binds USP8NL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9696267", "l": "RND3 binds GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254290", "l": "CSN2 gene expression is stimulated by ERBB4s80:STAT5A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8850997", "l": "TRIM27 binds PTEN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53997", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55328", "l": "9-cis-retinol + hexadecanoyl-CoA = 9-cis-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60929", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 17-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814153", "l": "ADO oxidises 2AET to HTAU (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39171", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH = (3R)-hydroxyeicosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909725", "l": "Interaction of IRF9 with p-STAT2:p-STAT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5362522", "l": "ALDHs oxidise atRAL to atRA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69469", "l": "2-oxoglutarate + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose => L-glutamate + UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29097", "l": "4 H(+)(out) + NAD(+) + ubiquinol-8 => 5 H(+)(in) + NADH + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419334", "l": "Melatonin receptors can bind melatonin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210309", "l": "Interaction of DAP12 and KIR2DS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610717", "l": "PKA phosphorylates GLI2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1977958", "l": "ERBB4 forms heterodimers with ERBB3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32352", "l": "3 S-adenosyl-L-methionine + tricetin => 3',4',5'-O-trimethyltricetin + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005117", "l": "wishful thinking binding", "d": ["Binding to wishful thinking (Wit), a type II bone morphogenic protein receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102702", "l": "2-carene synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (+)-2-carene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649734", "l": "LIG3 ligates NEIL1,NEIL2-generated single strand break (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33000", "l": "(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62389", "l": "[(1->2)-beta-D-glucosyl](n) + H2O => [(1->2)-beta-D-glucosyl](n-2) + sophorose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350475", "l": "FLW:MBS complex dephosphorylates SQH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622367", "l": "CEBPA mRNA is translated to yield CEBPA protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10898", "l": "2 H(+) + limonoate => 2 H2O + limonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77803", "l": "2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]acetate + H(+) + H2O = 2-dehydro-D-glucose + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977615", "l": "Factor I inactivates MCP/CR1-bound C4b/C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49896", "l": "(5aS)-5,5a-dihydrophenazine-1,6-dicarboxylate = 5,10-dihydrophenazine-1,6-dicarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29622", "l": "alpha-maltotetraose + beta-maltose <=> alpha-maltopentaose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001872", "l": "(1->3)-beta-D-glucan binding", "d": ["Binding to a (1->3)-beta-D-glucan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109860", "l": "MAP2K1 phosphorylates MAPK3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936951", "l": "Activation of TAK1 complex bound to activated TLR4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29616", "l": "alpha-maltotriose + beta-maltose => alpha-maltotetraose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090471", "l": "9,15,9'-tri-cis-zeta-carotene isomerase activity", "d": ["Catalysis of the reaction: 9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975629", "l": "RDH11 reduces RBP2:atRAL to RBP2:atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140814", "l": "glycine betaine:sodium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + Na+(out) + Cl-(out)= glycine betaine(in) + Na+(in) + Cl-(in)."], "t": []}, {"i": "RHEA:71175", "l": "2 chloride(out) + glycine betaine(out) + 3 Na(+)(out) = 2 chloride(in) + glycine betaine(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33550", "l": "H2O + lanosteryl hexadecanoate <=> H(+) + hexadecanoate + lanosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942803", "l": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047960", "l": "glycine dehydrogenase activity", "d": ["Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65497", "l": "3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH => 3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2038387", "l": "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4570489", "l": "SUMOylation of NOP58 with SUMO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8850797", "l": "SPINK6 binds KLK13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426489", "l": "RISC binds inexactly matching target RNAs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27445", "l": "NADP(+) + xylitol = D-xylose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21200", "l": "2-oxoglutarate + L-lysine = (S)-2-amino-6-oxohexanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.36", "l": "\"L-lysine 6-transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5671737", "l": "p-T774-PKN1 binds CDC25C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41177", "l": "methyl-Co(III)-[dimethylamine-specific corrinoid protein] + methylamine => Co(I)-[dimethylamine-specific corrinoid protein] + dimethylamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21155", "l": "trans-4-hydroxy-L-proline <=> cis-4-hydroxy-D-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9758090", "l": "Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24612", "l": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9613494", "l": "Unwinding of DNA for the Nascent Transcript: Second Transition (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58363", "l": "2-oxoglutarate + L-lysyl-[protein] + O2 <=> (5S)-5-hydroxy-L-lysyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140090", "l": "membrane curvature sensor activity", "d": ["Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952419", "l": "SMURFs ubiquitinate RUNX3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855237", "l": "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086392", "l": "PDE6 hydrolyses cGMP to GMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10447", "l": "(S)-reticuline + S-adenosyl-L-methionine <=> (S)-laudanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375135", "l": "Basigin binds Matrix metalloproteinase-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180009", "l": "broad specificity neutral L-amino acid:basic L-amino acid antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: basic L-amino acid(in) + neutral L-amino acid(out) = basic L-amino acid(in) + neutral L-amino acid(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17540", "l": "(R)-carnitinamide + H2O <=> (R)-carnitine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050334", "l": "thiaminase activity", "d": ["Catalysis of the reaction: H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57938", "l": "5-pyridoxate + 2 H(+) + NADH => H2O + isopyridoxal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32931", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a CDP-1,2-diacyl-sn-glycerol = a cardiolipin + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.41", "l": "\"cardiolipin synthase (CMP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76708", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione => (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69478", "l": "CoA + H(+) + N(6)-acetyl-L-lysine => acetyl-CoA + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15929", "l": "2 H(+) + 2 H2O + methylenediurea = CO2 + N-(hydroxymethyl)urea + 2 NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.3.21", "l": "\"methylenediurea deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27723", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose => 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24389", "l": "phosphate + uridine => alpha-D-ribose 1-phosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983259", "l": "Kinesins move along microtubules consuming ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625482", "l": "PTK2 binds activated EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-994148", "l": "LRRC16A binds F-actin capping protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67438", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33547", "l": "H2O + lanosteryl hexadecanoate = H(+) + hexadecanoate + lanosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033409", "l": "UAU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985943", "l": "p-Y701-STAT1 dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37271", "l": "ATP + H2O + L-alanyl-L-glutamine(out) = ADP + H(+) + L-alanyl-L-glutamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32893", "l": "alpha-pinene oxide + H2O + NAD(+) => (1S,5S)-alpha-pinene + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79091", "l": "an L-alpha-amino acid + taurocholate = an N-choloyl-L-alpha-amino acid + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007882", "l": "IL1F10 is cleaved (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65583", "l": "H2O + TTP <=> H(+) + phosphate + TDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56517", "l": "Fe-coproporphyrin III + 2 H(+) + 2 H2O2 => 2 CO2 + 4 H2O + heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047242", "l": "hydroxyanthraquinone glucosyltransferase activity", "d": ["Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877998", "l": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0048020", "l": "CCR chemokine receptor binding", "d": ["Binding to a CCR chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050090", "l": "mannuronate reductase activity", "d": ["Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5628871", "l": "BRD7 promotes EP300-mediated acetylation of TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59824", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate = L-glutamate + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801675", "l": "PLK2 phosphorylates NPM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43775", "l": "guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008980", "l": "propionate kinase activity", "d": ["Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44183", "l": "2-methylpropanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25830", "l": "A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O => AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654514", "l": "KAL1 binds FGFR1c (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853753", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57139", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.94", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28411", "l": "4-(gamma-L-glutamylamino)butanal + H2O + NADP(+) => 4-(gamma-L-glutamylamino)butanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193677", "l": "NRIF binds to p75NTR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449115", "l": "IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20637", "l": "D-fructose + D-glucose = D-glucono-1,5-lactone + D-sorbitol", "d": [], "t": []}, {"i": "EC:1.1.99.28", "l": "\"glucose-fructose oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66936", "l": "(E)-caffeoyl-CoA + 5-hydroxyanthranilate = avenanthramide C + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1067659", "l": "Assembly of hexameric IL-6 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005008", "l": "hepatocyte growth factor receptor activity", "d": ["Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61773", "l": "rebaudioside E + UDP-alpha-D-glucose => H(+) + rebaudioside D + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70017", "l": "7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + teasterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20640", "l": "D-fructose + D-glucose <=> D-glucono-1,5-lactone + D-sorbitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8865182", "l": "OTUD7A hydrolyses K11diUb (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853405", "l": "TPX2 binds AURKA at centrosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32490", "l": "CDP-choline + H2O <=> CMP + 2 H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2484965", "l": "Collagen type XIII binds Integrin alpha1beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70241", "l": "PCK1 phosphorylates OA to yield PEP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66804", "l": "ferruginol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + pisiferate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686440", "l": "MUS81:EME1,EME2 cleaves D-loop (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58906", "l": "C40-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+) => 8 (S)-methylmalonyl-CoA + 24 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37085", "l": "[sulfur carrier]-H + H(+) + L-aspartate(89)-[ribosomal protein uS12]-methanesulfate + S-adenosyl-L-homocysteine => [sulfur carrier]-SH + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59758", "l": "H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine => L-arginine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78761", "l": "2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + methylcyclopropylglycine-[protein] => AH2 + L-isoleucyl-[protein] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42032", "l": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate", "d": [], "t": []}, {"i": "EC:1.14.11.27", "l": "\"[histone H3]-dimethyl-L-lysine(36) demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70749", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59260", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70780", "l": "D-glucose + NADP(+) => 6-dehydro-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22758", "l": "a long-chain fatty aldehyde + H2O2 => a long-chain primary fatty alcohol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227867", "l": "TANK binds polyubiquitinated TRAF3/6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71423", "l": "3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) = 3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9825759", "l": "MAPK-dependent phosphorylation of KARS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31576", "l": "8-oxo-dGTP + H2O => 8-oxo-dGMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31356", "l": "dimethyl sulfide + H(+) + NADH + O2 => formaldehyde + H2O + methanethiol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905201", "l": "gibberellin transmembrane transporter activity", "d": ["Enables the transfer of gibberellin from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0010857", "l": "calcium-dependent protein kinase activity", "d": ["Calcium-dependent catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3262512", "l": "G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69860", "l": "a uridine in 12S rRNA + S-adenosyl-L-methionine => a 5-methyluridine in 12S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41908", "l": "(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0008126", "l": "acetylesterase activity", "d": ["Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60859", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32234", "l": "(6S)-NADPHX + ATP <=> ADP + H(+) + NADPH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388833", "l": "Phosphorylation of CTLA-4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654709", "l": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14220", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] <=> [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51963", "l": "(Z)-2-methylpropanal oxime <=> 2-methylpropanenitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59408", "l": "H2O + N-acetyl-L-aspartate = acetate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690845", "l": "TNIPs bind TNFAIP3 (A20) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43794", "l": "H(+) + N(1)-methyladenosine(645) in 25S rRNA + S-adenosyl-L-homocysteine => adenosine(645) in 25S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32683", "l": "5-hydroxymethylfurfural + 2 H2O + 3 O2 = 2,5-dicarboxyfuran + 2 H(+) + 3 H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.47", "l": "\"5-(hydroxymethyl)furfural oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602368", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[16] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-443779", "l": "Linkage of L1 with treadmilling F-actin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.326528101086026", "identifiers": [{"i": "GO:0003729", "l": "mRNA binding", "d": ["Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5686430", "l": "MUS81 binds EME1, EME2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52249", "l": "6 H2O + 4 Mn(3+) + O2 => 12 H(+) + 4 MnO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73768", "l": "cyclo(L-tryptophyl-L-alanyl) + dimethylallyl diphosphate => diphosphate + preechinulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "59.84650124334329", "identifiers": [{"i": "GO:0140098", "l": "catalytic activity, acting on RNA", "d": ["Catalytic activity that acts to modify RNA, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8985988", "l": "IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032031", "l": "myosin I head/neck binding", "d": ["Binding to the head/neck region of a myosin I heavy chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618098", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017075", "l": "syntaxin-1 binding", "d": ["Binding to a syntaxin-1 SNAP receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840401", "l": "DELE1(143-515) is released into the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64271", "l": "emodin anthrone + O2 <=> emodin + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021170", "l": "Estrogen stimulates dimerization of plasma membrane estrogen receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9838093", "l": "LONP1 binds mitochondrial matrix proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39669", "l": "a ketone + reduced coenzyme F420-(gamma-L-Glu)(n) => a secondary alcohol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42772", "l": "guanosine(1405) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(1405) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.179", "l": "\"16S rRNA (guanine(1405)-N(7))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10561", "l": "4-hydroxy-1-pyrroline-2-carboxylate + H(+) + H2O => 2,5-dioxopentanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28723", "l": "(S)-allantoin(in) + H(+)(in) = (S)-allantoin(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174731", "l": "Degradation of newly synthesized ApoB-48 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57203", "l": "glyoxal + L-arginyl-[protein] <=> N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50789", "l": "NADP(+) + pentan-2-one => (E)-pent-3-en-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193665", "l": "MYD88 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74539", "l": "creatinine(in) = creatinine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12249", "l": "NADP(+) + UDP-N-acetyl-alpha-D-muramate => H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23327", "l": "2'-phospho-[ligated tRNA] + NAD(+) <=> ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696960", "l": "USP49 deubiquitinates H2B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651723", "l": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22354", "l": "cadaverine + CO2 => H(+) + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250607", "l": "botD HC:LC binds SV2A or B or C and GD2 on the target cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58587", "l": "dihydroprecondylocarpine acetate <=> (-)-tabersonine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34613", "l": "H(+) + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + UDP => N-acyl-15-methylhexadecasphing-4-enine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4411373", "l": "NLK translocates to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55710", "l": "[ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + 2 H(+) + 3 H2O + nicotinamide => [ADP-thiazole synthase]-L-cysteine + glycine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114284", "l": "Release of Cytochrome c from mitochondria (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-352268", "l": "Cleavage of Satb1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204500", "l": "CyP60 chaperones Basigin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51431", "l": "acetyl-CoA + aminomethylphosphonate <=> 2-N-acetamidomethylphosphonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033874", "l": "scymnol sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-diphosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194025", "l": "11-deoxycortisol translocates to the mitochondrion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5419273", "l": "Hydrolysis of GTP and dissociation of 28S and 39S subunits (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870698", "l": "FASLG (FasL) gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39524", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA => (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446322", "l": "PARVA associates with Paxillin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18037", "l": "agmatine + H2O = N-carbamoylputrescine + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.3.12", "l": "\"agmatine deiminase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9716913", "l": "ESR1 binds ESR1 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47104", "l": "5,10-methylenetetrahydromethanopterin + glycine + H2O = 5,6,7,8-tetrahydromethanopterin + L-serine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2396337", "l": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27563", "l": "(2E)-geranyl diphosphate + 7 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 7 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.84", "l": "\"all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36675", "l": "octacosanoyl-CoA + sphinganine = CoA + H(+) + N-(octacosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47774", "l": "a 2'-O-methylguanosine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine => a guanosine in 21S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32501", "l": "(1S,3R,5S)-sabinol + H2O + NADP(+) => (1R,5R)-sabinene + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74136", "l": "petunidin + UDP-alpha-D-galactose => petunidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190686", "l": "Transport of connexins to the Trans-Golgi Network (TGN) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42040", "l": "a ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose = a ganglioside Fuc-GM1 (d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36265", "l": "acetate + H(+) + O-ureido-L-serine => hydroxyurea + O-acetyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62922", "l": "1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal => 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423728", "l": "AFXBO translocates from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29814", "l": "ATP + H2O + thiamine(out) <=> ADP + H(+) + phosphate + thiamine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176298", "l": "Activation of claspin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623588", "l": "Defective SLC12A1 does not cotransport Na+, K+, 2Cl- from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79144", "l": "L-serine + taurocholate => L-serocholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20864", "l": "alpha,alpha-trehalose 6-phosphate + phosphate = beta-D-glucose 1-phosphate + D-glucose 6-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.216", "l": "\"trehalose 6-phosphate phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18366", "l": "(R)-malate + NAD(+) => CO2 + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102220", "l": "hydrogenase activity (NAD+, ferredoxin)", "d": ["Catalysis of the reaction: 2 dihydrogen + NAD + 2 an oxidized ferredoxin = NADH + 3 H+ + 2 a reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804402", "l": "TP53 binds POU4F1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77923", "l": "O2 + sym-homospermidine = H2O2 + N-(4-aminobutylpyrrolinium) ion + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57933", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.39", "l": "\"glucan endo-1,3-beta-D-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37663", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.312", "l": "\"protein O-mannose beta-1,4-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35409", "l": "4'-methoxyisoflavan-2',4,7-triol => H2O + medicarpin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38207", "l": "19-oxo-androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] = estrone + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38943", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51365", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine => CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729283", "l": "Nucleoprotein is methylated by PRMT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610732", "l": "GSK3 phosphorylates p-GLI3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-432054", "l": "Aquaporin-1 passively transports water out of cell (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69550", "l": "CO2 + phosphoethanolamine => H(+) + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30293", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.253", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55794", "l": "1-hydroxy-2-butanone + H2O + NAD(+) => butan-2-one + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25377", "l": "a 2-methyl-branched fatty aldehyde + formyl-CoA => a 2-hydroxy-3-methyl fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755306", "l": "ub UBXN7 is degraded by the 26S proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55830", "l": "6beta-hydroxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cortisol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75521", "l": "(R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMN + H(+) + H2O => FMNH2 + N-acetyl-S-benzyl-L-cysteine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39310", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H(+) + NADPH <=> (11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388560", "l": "EDNRA,EDNRB bind EDNs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35854", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6800035", "l": "IGFBP3 binds TMEM219 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57215", "l": "dGTP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-dGTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2301205", "l": "SETD8 monomethylates histone H4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20666", "l": "1,5-anhydro-D-glucitol + NADP(+) => 1,5-anhydro-D-fructose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17835", "l": "3-hydroxy-4-methylanthranilate + H(+) + S-adenosyl-L-homocysteine => 3-hydroxyanthranilate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69251", "l": "H2O + sinigrin <=> (Z)-N-(sulfonatooxy)prop-2-enimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474213", "l": "Collagen type III degradation by MMP1,8,9,13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9749609", "l": "BCHE hydrolyzes ASA- (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2328037", "l": "Fibrillin-1 binds integrins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71750", "l": "2-oxoglutarate(out) + L-2-aminoadipate(in) <=> 2-oxoglutarate(in) + L-2-aminoadipate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043801", "l": "hexulose-6-phosphate synthase activity", "d": ["Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18438", "l": "4-CDP-2-C-methyl-D-erythritol + ATP => 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35147", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) = (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855165", "l": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63224", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9725117", "l": "ALK gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1433456", "l": "Recruitment of STATs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14504", "l": "H2O + L-homocysteine <=> 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043560", "l": "insulin receptor substrate binding", "d": ["Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102970", "l": "7-deoxyloganetic acid glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 7-deoxyloganetate = H+ + 7-deoxyloganate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30921", "l": "(3E)-3,4-didehydrorhodopin + AH2 => A + rhodopin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55862", "l": "all-trans-5,6-epoxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34348", "l": "(2E)-geraniol + NAD(+) => (2E)-geranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4420117", "l": "VEGFR2 autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507873", "l": "Aquaporins passively transport urea out of cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134800", "l": "STING dimerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615937", "l": "TPNO/KPNB1 (transportin/importin beta) sequester the Nup107-160 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77799", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)glycine + O2 = 2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]acetate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16918", "l": "2,6-dihydroxypyridine + H(+) + NADH + O2 => 2,3,6-trihydroxypyridine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380780", "l": "Activation of Src (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39573", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682018", "l": "MRN complex bound to shortened telomeres recruits ATM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849857", "l": "KLK5 cleaves and activates CELA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1168636", "l": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004711", "l": "ribosomal protein S6 kinase activity", "d": ["Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180016", "l": "SUMO ligase regulator activity", "d": ["Binds to and modulates the activity of a SUMO ligase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174097", "l": "Association of Emi1 with Cdh1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54901", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADH => hexadecanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20099", "l": "2-dehydro-3-deoxy-D-gluconate + H2O => D-mannonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50519", "l": "acetyl-CoA + N-terminal L-threonyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27999", "l": "H2O + thiamine diphosphate => H(+) + phosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62232", "l": "a thymidine(6-4)thymidine in DNA = a thymidine dimer in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399930", "l": "Activation of PAK by Rac1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22607", "l": "D-mannose <=> D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213243", "l": "Fusion of COPII vesicle with Golgi complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9008054", "l": "IL1F10 binds IL1RAPL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322429", "l": "XIAP monoubiquinates TLE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648017", "l": "EML4 binds to microtubules (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617815", "l": "BBSome binds RAB3IP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949661", "l": "C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798031", "l": "TP53 stimulates BTG2 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202127", "l": "eNOS synthesizes NO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210289", "l": "Recruitment of SYK to p-DAP12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2870221", "l": "E-selectin binds E-selectin ligand (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033954", "l": "alpha-neoagaro-oligosaccharide hydrolase activity", "d": ["Catalysis of the hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41246", "l": "N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine <=> N-acyl-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoate (4E)-octadecasphin-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034848", "l": "naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity", "d": ["Catalysis of the reaction: naphthyl-2-oxomethyl-succinyl-CoA + CoASH = 2-naphthoyl-CoA + succinyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676595", "l": "TRAFs bind RANK:RANKL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73806", "l": "AIR + CO2 => CAIR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-560517", "l": "Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322434", "l": "XIAP dissociates from ub-TLE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48584", "l": "2 H2O + 2 leukotriene A4 + O2 = 2 lipoxin A4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76356", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(out) => n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67308", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55728", "l": "19-(4-hydroxyphenyl)nonadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015526", "l": "hexose-phosphate:phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + phosphate(in) = hexose phosphate(in) +  phosphate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659820", "l": "RB1 translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177936", "l": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2197698", "l": "Src phosphorylate WASP,N-WASP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.118", "l": "\"phospholipid sn-1 acylhydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35458", "l": "5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 <=> (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32127", "l": "2-oxoglutarate + L-proline + O2 = cis-4-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.56", "l": "\"L-proline cis-4-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70475", "l": "2 S-adenosyl-L-methionine + sphing-4-enine = 2 H(+) + N,N-dimethylsphing-4-enine + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64566", "l": "ilicicolin H => 8-epi-ilicicolin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23459", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 <=> A + crepenynate + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74463", "l": "(-)-4'-methoxycyclopenine = 4'-methoxyviridicatin + H(+) + methyl isocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66203", "l": "O2 + pentanoyl-CoA <=> (2E)-pentenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22921", "l": "L-glutamine + scyllo-inosose => 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24481", "l": "a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O => a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17448", "l": "H2 + 2 oxidized [2Fe-2S]-[ferredoxin] <=> 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71595", "l": "2-oxoglutarate(out) + succinate(in) = 2-oxoglutarate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32954", "l": "sucrose <=> trehalulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15278", "l": "acetyl-CoA + L-lysyl-[alpha-tubulin] => CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28052", "l": "NAD(+) + phosphate => H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602484", "l": "Activation of proMMP11 by FURIN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374909", "l": "Catabolism of Noradrenaline (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2534096", "l": "METAP1/2 demethylates GNAT1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40908", "l": "2 2-hexadecanoyl-sn-glycero-3-phosphocholine => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034533", "l": "1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-7-hydroxymethylnaphthalene + O2 = 2-hydroxy-7-hydroxymethylchromene-2-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013158", "l": "CDC42 GDIs block activation of CDC42 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44584", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51160", "l": "cytidine(60) in tRNA(Asp) + S-adenosyl-L-methionine = 5-methylcytidine(60) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46796", "l": "an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-392749", "l": "Transport of L1 into endosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050023", "l": "L-fuconate dehydratase activity", "d": ["Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10962", "l": "(R)-lactate => (S)-lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850560", "l": "G-protein alpha releases G-protein heterotrimer from PDCL  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835328", "l": "NPM binds PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9748996", "l": "GST dimers cleave AZA to 6MP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198958", "l": "KIR2DL2/3 interacting with HLA-C group 1 (Cw4) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47536", "l": "3-oxochenodeoxycholate + H(+) + NADPH = isochenodeoxycholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629918", "l": "NEIL1 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47472", "l": "(2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH = (3E)-tetradecenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193653", "l": "NGF homodimer binds to p75NTR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0120284", "l": "tryptophan binding", "d": ["Binding to 2-amino-3-(1H-indol-3-yl)propanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62829", "l": "GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9724290", "l": "GNRHR2 binds GNRH1,2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102502", "l": "ADP-glucose-starch glucosyltransferase activity", "d": ["Catalysis of the reaction: ADP alpha-D-glucoside + n a 1,4-alpha-D-glucan = ADP + n alpha-amylose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51027", "l": "H(+) + NADH + O2 + toluene-4-sulfonate <=> 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42152", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13663", "l": "N-formyl-L-aspartate + NH4(+) => H2O + N-formimidoyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685268", "l": "SARS-CoV-1 8b binds NLRP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50066", "l": "ADP + H(+) + phosphate + taurochenodeoxycholate(out) => ATP + H2O + taurochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16752", "l": "H2O + phosphonoacetate <=> acetate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66730", "l": "ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38919", "l": "H2O + sphing-4-enine-phosphocholine = choline + H(+) + sphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050043", "l": "lactate racemase activity", "d": ["Catalysis of the reaction: (S)-lactate = (R)-lactate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1358789", "l": "Self-ubiquitination of RNF41 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6805740", "l": "SETD8 methylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61943", "l": "3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + UDP-alpha-D-glucose <=> 3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944250", "l": "Association of procollagen type XXV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685994", "l": "Long-range resection of DNA DSBs by EXO1 or DNA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389969", "l": "Beta-tubulin:GTP + Cofactor D ->  Beta-tubulin:GTP: Cofactor D (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111883", "l": "Hydrolysis of phosphatidylcholine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61187", "l": "quercitrin + UDP-beta-L-rhamnose <=> H(+) + quercetin 3,7-bis-O-alpha-L-rhamnoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26276", "l": "Co-precorrin-3 + S-adenosyl-L-methionine <=> Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33762", "l": "a 3-oxo-fatty acyl-CoA + H(+) + NADPH <=> a 3-hydroxy-fatty acyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380979", "l": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62831", "l": "GDP-beta-L-fucose + methyl-8-{[beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036354", "l": "2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity", "d": ["Catalysis of the reaction: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a = bacteriochlorophyllide a + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392752", "l": "Phosphorylation of L1 by CK-II (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015334", "l": "high-affinity oligopeptide transmembrane transporter activity", "d": ["Enables the transfer of oligopeptide from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31415", "l": "(2Z,6E)-farnesyl diphosphate = (+)-2-epi-prezizaene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665700", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607838", "l": "Defective UNC93B1 does not bind TLR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8863721", "l": "NEDD8-STON binds TOR1 hexamer and COP9 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15696", "l": "(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 <=> (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9008684", "l": "TBK1 phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40770", "l": "(20S)-ginsenoside R1 + H2O <=> (20S)-ginsenoside Rg1 + D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5444523", "l": "Formation of MSH1:PMS2 Complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46418", "l": "(6Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836362", "l": "p-PKR dimer phosphorylates TP53 tetramer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51879", "l": "2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate <=> desmethylxanthohumol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5228992", "l": "ROCK1,ROCK2 are activated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65841", "l": "ATP(out) + Mg(2+)(out) + phosphate(in) => ATP(in) + Mg(2+)(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33604", "l": "H(+) + N-hexacosanoylsphinganine + NADPH + O2 => H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62912", "l": "H(+) + NADH + O2 + toralactone = 1-(3,4,5-trihydroxy-7-methoxynaphthalen-2-yl)propan-2-one + CO2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102431", "l": "acyl-lipid omega-(9-4) desaturase activity", "d": ["Catalysis of the reaction: a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O. Can also use a substrate with 3 double bonds (a (9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid) and add a fourth double bond (a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70613", "l": "GOT2 transaminates OA and L-Glu (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51765", "l": "dimethylallyl diphosphate + phlorisovalerophenone => 4-prenylphlorisovalerophenone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54709", "l": "N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48872", "l": "a gentamycin + GTP = a gentamycin 2''-phosphate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.190", "l": "\"aminoglycoside 2''-phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38949", "l": "12-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70501", "l": "PC carboxylates PYR to OA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57299", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O <=> a 2'-deoxyguanosine in DNA + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034541", "l": "dimethylarsinite methyltransferase activity", "d": ["Catalysis of the reaction: dimethylarsenous acid + R2S-CH3 = trimethylarsine oxide + R2SH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670054", "l": "Defects in F8 A2 domain accelerate dissociation of the A2 domain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668404", "l": "TNFA binds TNFR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39161", "l": "(2E)-hexadecenoyl-CoA + H2O => (3R)-hydroxyhexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40511", "l": "(2S)-3-sulfopropanediol + NAD(+) = (2S)-3-sulfolactaldehyde + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.373", "l": "\"sulfolactaldehyde 3-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31799", "l": "4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56215", "l": "O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005113", "l": "patched binding", "d": ["Binding to a patched (ptc) protein, a receptor for hedgehog proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801666", "l": "PLK2 phosphorylates CENPJ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35537", "l": "cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2 => cyclo(L-phenylalanyl-L-leucyl) + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450325", "l": "c-FOS activation by phospho ERK1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42569", "l": "2,3-dihydroxy-p-cumate + O2 => 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625814", "l": "SPHK1 phosphorylates sphingosine in response to E2 stimulation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77454", "l": "hydrogen cyanide + piperonal <=> (2S)-2-(2H-1,3-benzodioxol-5-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76648", "l": "(3S)-3-hydroxyadipyl-CoA => (E)-2,3-didehydroadipoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46958", "l": "(E)-caffeoyl-CoA + 2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] => hydrocaffeoyl-CoA + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17902", "l": "S-adenosyl-L-methionine + xanthotoxol => H(+) + S-adenosyl-L-homocysteine + xanthotoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419049", "l": "ROCK activation by RHO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24285", "l": "L-aspartate 4-semialdehyde + NADP(+) + phosphate => 4-phospho-L-aspartate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22836", "l": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.41", "l": "\"beta-ketoacyl-[acyl-carrier-protein] synthase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10019", "l": "H2O + O-sinapoylcholine <=> (E)-sinapate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8869580", "l": "DEK binds TFAP2A homodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60693", "l": "(E)-non-2-enal + H2O + NADP(+) => (E)-non-2-enoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15736", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O <=> (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26391", "l": "all-trans-10'-apo-beta-carotenal + beta-ionone => all-trans-beta-carotene + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183058", "l": "Phosphorylation of CBL (EGFR:GRB2:CBL) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011543", "l": "DCA binds PDK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839379", "l": "TGFBR3 binding to FGF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73849", "l": "17alpha-sitoindoside IX + H(+) + UDP => 17alpha-hydroxywithaferin A + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48374", "l": "a fatty acid + acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) => 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-571324", "l": "IRAK2 binds to p-IRAK4:MyD88:activated TLR7 or 21 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25817", "l": "H2O + norspermine + O2 => 3-aminopropanal + H2O2 + norspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-264865", "l": "Caspase-mediated cleavage of Lamin A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35174", "l": "H(+)(out) + novobiocin(in) <=> H(+)(in) + novobiocin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.7", "l": "\"DNA ligase (ATP, ADP or GTP)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16791", "l": "a 2-oxocarboxylate + H2O2 => a (2S)-2-hydroxycarboxylate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70023", "l": "4-hydroxy-L-proline(in) + Na(+)(in) = 4-hydroxy-L-proline(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9726509", "l": "NR3C2 binds fludrocortisone (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22671", "l": "2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine <=> H(+) + lipid A disaccharide (E. coli) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19720", "l": "H(+) + L-phenylalanine <=> 2-phenylethylamine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12843", "l": "L-alanine + pyridoxal => pyridoxamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8949580", "l": "F1Fo ATP synthase dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47430", "l": "3-oxo-(9Z-octadecenoyl)-CoA + H(+) + NADH => (3S)-hydroxy-(9Z-octadecenoyl)-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33296", "l": "L-hexahomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-9-(methylsulfanyl)nonanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373747", "l": "Phosphorylation of nephrin by FYN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36060", "l": "A + dihydrourocanate => AH2 + urocanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75432", "l": "32-hydroxyeburicol + O2 + reduced [NADPH--hemoprotein reductase] => 32-oxoeburicol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46966", "l": "2 NADH + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate => lactate + 2 NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42897", "l": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine => H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42686", "l": "L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide => gamma-L-glutamyl-hercynylcysteine S-oxide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24378", "l": "AMP + diphosphate + H(+) + holo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] => apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] + ATP + biotin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43262", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.-.-", "l": "\"Intramolecular oxidoreductases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20312", "l": "2 H2O2 <=> 2 H2O + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46855", "l": "5alpha-cholest-8-en-3-one + H(+) + NADPH <=> 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.-.-", "l": "\"Carbon-carbon lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693061", "l": "STAMBP binds STAM (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41898", "l": "NADP(+) + tetradecanoyl-[ACP] => (2E)-tetradecenoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47983", "l": "dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose <=> dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782004", "l": "Assembly of the pre-incision complex in TC-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33902", "l": "FAD + H(+) + trans,octa-cis-decaprenylphospho-beta-D-ribofuranose <=> FADH2 + trans,octa-cis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68656", "l": "7-oxocholesterol + H(+) + NADPH = 7beta-hydroxycholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20218", "l": "H(+) + trimethylamine N-oxide => dimethylamine + formaldehyde", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.91", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29673", "l": "Ca(2+)(out) => Ca(2+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71487", "l": "H2O + Leu-enkephalin = L-phenylalanyl-L-leucine + L-tyrosylglycylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78555", "l": "Cs(+)(in) = Cs(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78799", "l": "a D-alpha-amino acid + O2 = a 2-iminocarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18577", "l": "3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 3-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.302", "l": "\"3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71284", "l": "chloride(out) + L-glutamine(out) + 2 Na(+)(out) => chloride(in) + L-glutamine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54962", "l": "AMP + dinor-OPDA-CoA + diphosphate => ATP + CoA + dinor-OPDA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71080", "l": "cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase] => cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109341", "l": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36435", "l": "a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-glycero-3-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3240957", "l": "Formation of PRC2-EZH2 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674018", "l": "BRAP binds RAS:GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1363311", "l": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12563", "l": "hydroquinone + UDP-alpha-D-glucose <=> H(+) + hydroquinone O-beta-D-glucopyranoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047068", "l": "N5,N10-methenyltetrahydromethanopterin hydrogenase activity", "d": ["Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31648", "l": "beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O => 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928597", "l": "EPH:EFN dimers tetramerise (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603775", "l": "PEX3:PEX19:class I PMP dissociates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9855212", "l": "SDHA binds to SDHB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15962", "l": "4-hydroxymandelonitrile + UDP-alpha-D-glucose => H(+) + taxiphyllin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29576", "l": "L-serine(in) + Na(+)(in) => L-serine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.124", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63688", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61976", "l": "glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18711", "l": "AH2 + NH4(+) + sulfoacetaldehyde => A + H2O + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22655", "l": "2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + H2O <=> 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43338", "l": "CO2 + N(6)-biotinyl-L-lysyl-[protein] + n Na(+)(out) => H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + n Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679477", "l": "VEGFA-165 dimer binds VEGFA inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9909159", "l": "HK1 phosphorylates Mannose to Man6P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2169046", "l": "Degradation of TGF-beta receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687123", "l": "p-S115 MAPKAPK5 translocates to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17933", "l": "a 7-hydroxyisoflavone + S-adenosyl-L-methionine = a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.150", "l": "\"isoflavone 7-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68934", "l": "AMP + diphosphate + NADP(+) + octanal => ATP + H(+) + NADPH + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173739", "l": "Spontaneous hydrolysis of C3 thioester (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39041", "l": "a dicarboxylate + 2 H(+) + NADH => an omega-oxo fatty acid + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32700", "l": "(2E,6E)-farnesyl diphosphate => beta-sesquiphellandrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8868118", "l": "MAPK12 phosphorylates PTPN3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706304", "l": "Active FLT3 binds to GRAP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10969", "l": "a carboxylate + CoA + GTP => an acyl-CoA + GDP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9861734", "l": "PDH E1 decarboxylates PYR, transferring acetyl to DLAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18689", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.32", "l": "\"phospholipase A1\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985201", "l": "ABCE1 binds RNASEL (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047748", "l": "cholestanetetraol 26-dehydrogenase activity", "d": ["Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57907", "l": "2-oxoglutarate + a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + O2 <=> a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46547", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212706", "l": "Phospholipase C-gamma1 binds to the activated EGF receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694581", "l": "RTC synthesizes SARS-CoV-2 plus strand genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59543", "l": "(2R)-ethylmalonyl-CoA + H(+) <=> butanoyl-CoA + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110215", "l": "Cleavage of uracil by UNG glycosylase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30856", "l": "dammarenediol-II => (S)-2,3-epoxysqualene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67900", "l": "glutarate + succinyl-CoA = glutaryl-CoA + succinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21501", "l": "UDP-alpha-D-glucose => H2O + UDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15576", "l": "N-acetylserotonin + S-adenosyl-L-methionine <=> H(+) + melatonin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420202", "l": "PLCG1 disassociates from VEGFR2 and translocate to PM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59905", "l": "H2O + NADP(+) + octanal => 2 H(+) + NADPH + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16545", "l": "formyl-CoA + oxalate = formate + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31884", "l": "(S)-2,3-epoxysqualene => delta-amyrin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35145", "l": "2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA => benzoyl-CoA + 2 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805035", "l": "TP53 binds STK11 and NUAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39600", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67423", "l": "a glycerophospholipid + H2O <=> a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30689", "l": "glyoxylate + pyruvate => (4R)-4-hydroxy-2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770119", "l": "Formation of the Spliceosomal E complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36051", "l": "beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose", "d": [], "t": []}, {"i": "EC:3.2.1.185", "l": "\"non-reducing end beta-L-arabinofuranosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74825", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374919", "l": "Noradrenaline clearance from the synaptic cleft (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70342", "l": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679028", "l": "JAK3 binds JAK3 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61225", "l": "H2O + L-asparagine + O2 => 2-oxosuccinamate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952749", "l": "STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76669", "l": "2-furoate + 2 H(+) + NADH => furfural + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9858647", "l": "HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483089", "l": "PE is converted to PS by PTDSS2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20732", "l": "[protein]-dithiol + [thioredoxin]-disulfide = [protein]-disulfide + [thioredoxin]-dithiol", "d": [], "t": []}, {"i": "EC:1.8.4.16", "l": "\"thioredoxin:protein disulfide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35148", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) => (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73757", "l": "Binding of RRN3 to RNA Polymerase I (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54948", "l": "(3R)-hydroxy-(5Z)-dodecenoyl-[ACP] = (2E,5Z)-dodecadienoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140978", "l": "TRADD:TRAF2:RIP1 complex binds FADD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36184", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline => a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9833777", "l": "PKR binds activating host RNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28732", "l": "H(+)(out) + L-leucine(in) => H(+)(in) + L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.63", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807229", "l": "Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046917", "l": "triphosphoribosyl-dephospho-CoA synthase activity", "d": ["Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000035", "l": "acyl binding", "d": ["Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607728", "l": "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202248", "l": "Phosphorylation of PLC-gamma1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20457", "l": "D-arabinose + NAD(+) = D-arabinono-1,4-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9627369", "l": "SEPT4 binds XIAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8948136", "l": "ULK1 Translocates to the mitochondria (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421416", "l": "Proglucagon translocates from the ER Lumen to secretory granules (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28599", "l": "H2O + N-acetyl-L-lysine => acetate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031961", "l": "nuclear cortisol receptor binding", "d": ["Binding to a nuclear cortisol receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39427", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH = (23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0004222", "l": "metalloendopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004912", "l": "interleukin-3 receptor activity", "d": ["Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156699", "l": "Inactivation of Wee1 kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797993", "l": "TP53 and CREBBP bind BNIP3L gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.55", "l": "\"non-reducing end alpha-L-arabinofuranosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033019", "l": "5-hydroxyvalerate dehydrogenase activity", "d": ["Catalysis of the reaction: 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2467436", "l": "AGRN binds Integrins alphaVbeta1 (Other beta1-containing integrins) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55033", "l": "an N-methylornithine lipid + S-adenosyl-L-methionine => an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170159", "l": "Translocation of Cdc25 to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46896", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A (E. coli) = a 1,2-diacyl-sn-glycerol + lipid A hexaacyl 1-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809707", "l": "MTMR12 binds MTMR2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-112437", "l": "Formation of NELF complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102385", "l": "patchoulol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = seychellene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67695", "l": "ATP + H2O + hexadecanedioate(in) <=> ADP + H(+) + hexadecanedioate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218826", "l": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48561", "l": "H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate => D-ribose 5-phosphate + N(6)-dimethylallyladenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062047", "l": "pipecolic acid N-hydroxylase", "d": ["Catalysis of the reaction: L-pipecolic acid + NAD(P)H + O2 + H+ = N-hydroxypipecolic acid + NAD(P)+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855197", "l": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23582", "l": "prostaglandin I2 => prostaglandin H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2129353", "l": "Tropoelastin associates with microfibrils (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23048", "l": "(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855210", "l": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5632732", "l": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247843", "l": "secretion of WNT ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41980", "l": "3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) = 5alpha-pregnane-3,20-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609860", "l": "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019785", "l": "ISG15-specific peptidase activity", "d": ["A thiol-dependent isopeptidase activity that cleaves ISG15 from a target protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69517", "l": "N-acetyl-D-galactosamine + O2 => H2O2 + N-acetyl-D-galactosamino-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629679", "l": "PDE3A inhibitors bind PDE3A (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429798", "l": "SGMS1 transfers phosphocholine onto ceramide (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204947", "l": "Polyubiquitinated NRIF migrates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38426", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52698", "l": "a 1,2-diacyl-3-O-[alpha-D-galactopyranosyl-(1->2)-alpha-D-glucopyranosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645481", "l": "TIFA oligomerization (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-984606", "l": "Kinesin-5 is a homotetramer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.20", "l": "\"phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71194", "l": "an L-alpha-amino acid(in) + L-kynurenine(out) <=> an L-alpha-amino acid(out) + L-kynurenine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29889", "l": "ADP + H(+) + L-lysine(in) + phosphate => ATP + H2O + L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56163", "l": "an archaeal dolichyl alpha-D-glucosyl phosphate + UDP-alpha-D-glucuronate <=> an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55633", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454916", "l": "The ABCC family mediates organic anion transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400143", "l": "Fatty acid ligands activate PPARA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-428185", "l": "Ceramide synthases transfer acyl-CoA onto sphingoid (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983870", "l": "JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58523", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] <=> akuammicine + formate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672950", "l": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0051082", "l": "unfolded protein binding", "d": ["Binding to an unfolded protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74383", "l": "2 (S)-lactate(in) + prostaglandin E2(out) = 2 (S)-lactate(out) + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-173542", "l": "SMURF2 ubiquitinates SMAD2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694793", "l": "Spike protein gets N-glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613352", "l": "PLINs bind HSPA8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32675", "l": "alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose", "d": [], "t": []}, {"i": "EC:3.2.1.28", "l": "\"alpha,alpha-trehalase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9861616", "l": "DLD dimer dehydrogenates dihydrolipoyl (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16037", "l": "phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682983", "l": "ATM phosphorylates WHSC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27594", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + 5 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.85", "l": "\"all-trans-nonaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55056", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.49", "l": "\"12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0008775", "l": "acetate CoA-transferase activity", "d": ["Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53576", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418163", "l": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.107", "l": "\"limonene 1,2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68949", "l": "esculetin + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912734", "l": "CBL:CRKL binds RAPGEF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40345", "l": "acetyl-CoA + tetradecanedioyl-CoA => 3-oxohexadecanedioyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41047", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2219524", "l": "PDPK1 binds PIP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23325", "l": "2'-phospho-[ligated tRNA] + NAD(+) => ADP-alpha-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24841", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018626", "l": "2-chlorobenzoate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21999", "l": "a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA <=> a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60740", "l": "(S)-(-)-citronellal + H2O + NADP(+) = (S)-(-)-citronellate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052793", "l": "pectin acetylesterase activity", "d": ["Catalysis of the reaction: pectin + H2O = pectate + acetate. This reaction is the hydrolysis of acetyl esters of pectin, producing pectate, partially esterified pectin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21211", "l": "H2O + O-phospho-L-serine <=> L-serine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014141", "l": "HEY2 gene expression is positively regulated by NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201634", "l": "Caspase-mediated cleavage of FADK 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70307", "l": "beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110235", "l": "OGG1 glycosylase mediated recognition and binding of an 8-oxoguanine opposite to a cytosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008701", "l": "4-hydroxy-2-oxovalerate aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43580", "l": "A + D-arginine = AH2 + iminoarginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-939763", "l": "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56545", "l": "H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15864", "l": "3-ADP-2-phosphoglycerate + H2O <=> 3-ADP-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201515", "l": "Active ALK recruits PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68621", "l": "cortisone + H(+) + NADPH => 20beta-dihydrocortisone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60967", "l": "(9Z)-17-hydroxyoctadec-9-enoate 17-O-beta-D-glucoside + UDP-alpha-D-glucose <=> (9Z)-17-hydroxyoctadec-9-enoate 17-O-sophoroside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265423", "l": "Interaction of integrin alphaVbeta3 with Fibrillin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043008", "l": "ATP-dependent protein binding", "d": ["Binding to a protein or protein complex using energy from ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051990", "l": "(R)-2-hydroxyglutarate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749590", "l": "ASA- acetylates ALB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65090", "l": "asperaculane G + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane E + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070380", "l": "high mobility group box 1 receptor activity", "d": ["Combining with high mobility group box 1 (HMBGB1) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16281", "l": "ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.88", "l": "\"dihydrostreptomycin-6-phosphate 3'alpha-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.-", "l": "\"With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855225", "l": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849094", "l": "ARHGAP35 binds RASA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51957", "l": "(E)-2-methylpropanal oxime => (Z)-2-methylpropanal oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19017", "l": "(6S)-NADHX + ATP = ADP + H(+) + NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813740", "l": "GDE1 hydrolyzes GroPIns (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42534", "l": "pseudouridine(55) in tRNA => uridine(55) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32603", "l": "(6E)-8-hydroxygeraniol + NADP(+) = (6E)-8-oxogeraniol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12696", "l": "3,4-dihydroxypyridine + O-acetyl-L-serine <=> 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667563", "l": "AVPR2 bind desmopressin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55945", "l": "2-chloroethanol + 2 Fe(III)-[cytochrome c] => chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983983", "l": "p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629187", "l": "TP53 binds regulatory elements of SESN1,2,3 genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28823", "l": "H(+)(in) + L-galactonate(in) = H(+)(out) + L-galactonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371518", "l": "SIRT1 binds to HSF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043837", "l": "valine dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.164", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380942", "l": "LKB1 forms a trimeric complex with STRAD and MO25 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45713", "l": "3-dehydrocarnityl-CoA + CoA => acetyl-CoA + N,N,N-trimethylglycyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964634", "l": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42399", "l": "cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine <=> 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5173192", "l": "POFUT2 transfers fucose to TSR domain-containing proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389609", "l": "ALDH3A2-2 oxidizes pristanal to pristanate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5226979", "l": "ADD1:ADD2 binds DMTN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43705", "l": "ATP + H(+) + tetradecanoate => diphosphate + tetradecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090542", "l": "ELYC domain binding", "d": ["Binding to a ELYC protein domain. The ELYC domain is an approximately 150 amino acid sequence which contains a highly conserved tetrapeptide sequence, ELYC."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025999", "l": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944232", "l": "Association of procollagen type XII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47947", "l": "(2E)-geranyl diphosphate + H2O <=> (2E)-geranyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28173", "l": "(2R)-2-hydroxy-2-methylbutanenitrile <=> butan-2-one + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9838093", "l": "LONP1 binds mitochondrial matrix proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18619", "l": "ADP + CO2 + phosphoenolpyruvate => ATP + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9668831", "l": "CST complex formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43587", "l": "H2O + iminoarginine <=> 5-guanidino-2-oxopentanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44511", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75872", "l": "Conversion of malonyl-CoA and acetyl-CoA to palmitate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173631", "l": "Activation of C1s (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14705", "l": "2 CoA + NADP(+) = CoA-disulfide + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.8.1.14", "l": "\"CoA-disulfide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8954117", "l": "E2F6:TFDP1 binds EPC1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14339", "l": "adenosine 3',5'-bisphosphate + H(+) + UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate => 3'-phosphoadenylyl sulfate + UDP-N-acetyl-alpha-D-galactosamine 4-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682992", "l": "KDM4A,B bind H4K20Me2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814831", "l": "TBC1D20 binds RAB1:GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17996", "l": "ATP + beta-alanine + gamma-L-glutamyl-L-cysteine <=> ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69457", "l": "3beta-hydroxy-5alpha-androstane-7,17-dione + H(+) + NADPH => 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78241", "l": "(R)-3-hydroxy-2-oxobutanoate + H2O2 + NH4(+) => D-allo-threonine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180033", "l": "histone H4K48 deacetylase activity", "d": ["Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 12) + H2O = histone H4 L-lysine (position 48) + acetate. This reaction represents the removal of an acetyl group from lysine at position 48 of the histone H4 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690196", "l": "USP8 deubiquitinates RNF128 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11249", "l": "[(3R)-hydroxybutanoate](n) + H2O => (R)-3-hydroxybutanoate + [(3R)-hydroxybutanoate](n-1) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218642", "l": "PTK2 autophosphorylates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9820853", "l": "AGO2 binds maternal endosiRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19678", "l": "9'-cis-neoxanthin + O2 => (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805103", "l": "AURKA phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389639", "l": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30599", "l": "15-cis-phytoene + 3 A = 3 AH2 + all-trans-neurosporene", "d": [], "t": []}, {"i": "EC:1.3.99.28", "l": "\"phytoene desaturase (neurosporene-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47279", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017507", "l": "RHOJ binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938867", "l": "CCND3,(CCND1,CCND2) binds RUNX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66834", "l": "diphosphate + preasperterpenoid A => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9679044", "l": "FKBP1A binds sirolimus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-983150", "l": "Proteasomal cleavage of substrate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690250", "l": "p-T182-MAPKAPK5 phoshphorylates DNAJB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848596", "l": "PTK6 binds PXN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53269", "l": "L-ribulose => L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9006870", "l": "IL21 receptor STAT phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-167419", "l": "The receptor:G-protein complex releases GDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562604", "l": "BfrA stores iron (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74986", "l": "Elongation of pre-rRNA transcript (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9726949", "l": "PTGIR binds PTGIR agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9858752", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54282", "l": "(3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46301", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1370500", "l": "PRLR binds SCF beta-TrCP complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12119", "l": "A + H2 <=> AH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000433", "l": "SUMOylation of PML with SUMO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47352", "l": "a hexanoate ester + H2O = an aliphatic alcohol + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210290", "l": "Interaction of PECAM-1 and SHIP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51198", "l": "chloride(in) + Na(+)(in) + serotonin(in) => chloride(out) + Na(+)(out) + serotonin(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76350", "l": "(2R,3S)-3-isopropylmalate(in) + sulfate(out) <=> (2R,3S)-3-isopropylmalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40687", "l": "1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol = 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14973", "l": "L-aspartate = D-aspartate", "d": [], "t": []}, {"i": "EC:5.1.1.13", "l": "\"aspartate racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24402", "l": "ADP + UDP => ATP + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50741", "l": "H2O + leukotriene C4 => glycine + leukotriene F4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0019864", "l": "IgG binding", "d": ["Binding to an immunoglobulin of an IgG isotype."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16734", "l": "H(+) + orsellinate => CO2 + orcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59855", "l": "(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH <=> (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36508", "l": "docosanoyl-CoA + H(+) + malonyl-CoA => 3-oxotetracosanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49613", "l": "(R)-2-hydroxyglutarate + NAD(+) => 2-oxoglutarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21278", "l": "D-xylulose + H(+) + NADPH => D-arabinitol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6786096", "l": "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33166", "l": "beta-nicotinamide D-riboside(in) <=> beta-nicotinamide D-riboside(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5685605", "l": "SLAMF7 binds SLAMF7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47670", "l": "2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13402", "l": "(2E,6E)-farnesol => (2Z,6E)-farnesol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52200", "l": "1-aci-nitro-2-(phenyl)ethane + glutathione = (Z)-1-(glutathione-S-yl)-2-phenylacetohydroximate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047099", "l": "CDP-4-dehydro-6-deoxyglucose reductase activity", "d": ["Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2142859", "l": "Growing HA is extruded from the cell by ABCC5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8933452", "l": "YWHAE dimer binds phosphorylated DENND1 proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70481", "l": "TPI1 isomerizes GA3P to DHAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043994", "l": "histone H3K23 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50389", "l": "5a,11a-dehydrotetracycline + H(+) + NADPH + O2 => 5a,11a-dehydrooxytetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56238", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27732", "l": "beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate => 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668718", "l": "NOX1 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70601", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA => a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58663", "l": "a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine <=> a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26340", "l": "L-homocysteine + S-methyl-L-methionine <=> H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71100", "l": "androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) => androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16447", "l": "daidzein + H(+) + H2O => (2R,3S)-2,4',7-trihydroxyisoflavanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211467", "l": "HNF1A-dependent synthesis of HNF4G protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47873", "l": "a ganglioside GM1 + H2O => a ganglioside GA1 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2219524", "l": "PDPK1 binds PIP2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788611", "l": "HYKK phosphorylates 5HLYS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40173", "l": "(2E)-dodecenoyl-CoA + H2O2 => dodecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20686", "l": "galactitol + NAD(+) => H(+) + keto-D-tagatose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873946", "l": "OTUD3 deubiquitinates PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855232", "l": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0017153", "l": "sodium:dicarboxylate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654578", "l": "Activated FGFR1 phosphorylates FRS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174931", "l": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392133", "l": "G alpha (z) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759522", "l": "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5340124", "l": "CSN polymer binds CaPO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14186", "l": "3-phenylpyruvate + H(+) => 2-phenylacetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034560", "l": "bisphenol A hydroxylase A activity", "d": ["Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20862", "l": "(6R)-isopiperitenone + H(+) + NADH => (1S,6R)-isopiperitenol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1630304", "l": "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31837", "l": "dTDP-3-dehydro-6-deoxy-alpha-D-galactose => dTDP-4-dehydro-6-deoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53053", "l": "4-hydroxyestrone + UDP-alpha-D-glucuronate => 4-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38970", "l": "an N-acylsphing-4-enine(in) + ATP + H2O <=> ADP + an N-acylsphing-4-enine(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3965450", "l": "DAAM1 recruits PFN1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51366", "l": "CoA + H(+) + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63356", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2 = (S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69442", "l": "3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH => 3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120242", "l": "2-iminobutanoate deaminase activity", "d": ["Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050317", "l": "tagatose kinase activity", "d": ["Catalysis of the reaction: D-tagatose + ATP = D-tagatose 6-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66231", "l": "asc-C13-CoA + O2 <=> asc-DeltaC13-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41082", "l": "1-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340124", "l": "CSN polymer binds CaPO4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49423", "l": "ATP + valienone <=> ADP + H(+) + valienone 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0051734", "l": "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA."], "t": []}, {"i": "EC:2.7.1.78", "l": "\"polynucleotide 5'-hydroxyl-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.24", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69832", "l": "campestanol + O2 + reduced [NADPH--hemoprotein reductase] => 6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62390", "l": "[(1->2)-beta-D-glucosyl](n-2) + sophorose => [(1->2)-beta-D-glucosyl](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47012", "l": "[DsrC protein]-disulfide + H(+) + hydrogen sulfide = [DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18914", "l": "a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75186", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> diphosphate + lydicene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730862", "l": "Autophosphorylation of LYN kinase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9734687", "l": "ORC6 is phosphorylated on T195 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63192", "l": "[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + O2 = glycine betaine + 2 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:1.13.11.90", "l": "\"[1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase (glycine-betaine-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44278", "l": "4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA => eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72682", "l": "(R)-dihydrolipoate + ATP + L-lysyl-[lipoyl-carrier protein] <=> AMP + diphosphate + H(+) + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11104", "l": "N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-methionine = H(+) + hercynine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46710", "l": "AMP + H(+) + salicyl-[ACP] => 2-hydroxybenzoyl-5'-AMP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015540", "l": "3-hydroxyphenyl propionate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080069", "l": "7-methylthioheptyl-desulfoglucosinolate sulfotransferase activity", "d": ["Catalysis of the reaction: 7-methylthioheptyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 7-methylthioheptyl-glucosinolate + adenosine 3',5'-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9612509", "l": "SGK phosphorylates SRF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22615", "l": "(3S)-citramalyl-CoA <=> acetyl-CoA + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070774", "l": "phytoceramidase activity", "d": ["Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78389", "l": "L-cysteinyl-[SCAN] + S-nitroso-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-nitroso-L-cysteinyl-[SCAN]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517731", "l": "Expression of IL-8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51748", "l": "4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A = 4-amino-4-deoxy-beta-L-arabinopyranosyl-lipid A + di-trans,octa-cis-undecaprenyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679775", "l": "COMT binds COMT Inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53107", "l": "4-hydroxyestrone + S-adenosyl-L-methionine <=> 4-methoxyestrone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726509", "l": "NR3C2 binds fludrocortisone (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839390", "l": "TGFBR3 complex binds to TGFBR2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69092", "l": "H2O + NAD(+) + pentanal = 2 H(+) + NADH + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10449", "l": "2-oxoglutarate + a flavanone + O2 => a flavone + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55163", "l": "coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9844955", "l": "CLN3 transports GalCer to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24791", "l": "(2E)-2-hydroxypenta-2,4-dienoate + H(+) + succinate => (2E,4Z)-2-hydroxy-6-oxononadienedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15053", "l": "(6R)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}, {"i": "EC:2.1.2.2", "l": "\"phosphoribosylglycinamide formyltransferase 1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34770", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O <=> (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9021357", "l": "PRKCI phosphorylates ELF3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54335", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline <=> 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696605", "l": "USP12, USP26 deubiquitinate AR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50469", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH => 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70089", "l": "hydroxyclavatol methyl ether => methanol + o-quinone methide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26299", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O => 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043771", "l": "cytidine kinase activity", "d": ["Catalysis of the reaction: ATP + cytidine = ADP + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68189", "l": "dodecanoyl-CoA + phytol => CoA + dodecanoate phytyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71163", "l": "HPD dioxygenates HPP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203611", "l": "N-myristoylation of eNOS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1592371", "l": "Initial activation of proMMP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68802", "l": "alpha-D-glucose + D-glucose => H2O + nigerose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170026", "l": "UCP1 imports a proton (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975916", "l": "Addition of GlcNAc to position 5 by MGAT5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205244", "l": "Recruitment of CBL to KIT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67437", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32064", "l": "8-oxo-dGDP + H2O => 8-oxo-dGMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109857", "l": "MAP2K1 binds MAPK3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0043916", "l": "DNA-7-methylguanine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0031210", "l": "phosphatidylcholine binding", "d": ["Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381727", "l": "RAP1A exchanges GDP for GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672951", "l": "Inactive RAFs bind YWHAB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004719", "l": "protein-L-isoaspartate (D-aspartate) O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090038", "l": "NAGLU hydrolyses heparan chain(2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191825", "l": "Nuclear export of snRNA transcripts (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849881", "l": "SALM2 associate with AMPA and NMDA receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52041", "l": "L-cystine => 2-aminoprop-2-enoate + S-sulfanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29331", "l": "fumarate(in) + 2 H(+)(in) = fumarate(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955030", "l": "NADK2 dimer phosphorylates NAD+ to NADP+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39487", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA = (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672969", "l": "Phosphorylation of RAF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013435", "l": "RHOD auto-activates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39484", "l": "3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000102", "l": "L-methionine secondary active transmembrane transporter activity", "d": ["Enables the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696275", "l": "RND2 binds GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0004565", "l": "beta-galactosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417908", "l": "P2RY1 binds ADP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58652", "l": "rifamycin SV ortho-naphthoquinone carboxamide = rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097253", "l": "beta-hydroxybutyrate transmembrane transporter activity", "d": ["Enables the transfer of beta-hydroxybutyrate from one side of a membrane to the other. Beta-hydroxybutyrate is the conjugate base of (R)-3-hydroxybutyric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433418", "l": "Phosphorylation of JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-186819", "l": "SH2 domain of Src binds to the active receptor (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817575", "l": "ERO1B oxidizes P4HB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23950", "l": "H(+) + NADH + succinate semialdehyde => 4-hydroxybutanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46695", "l": "4-hydroxybenzoate + ATP + H(+) <=> 4-hydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14391", "l": "an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66550", "l": "4-nitrophenyl sulfate + adenosine 3',5'-bisphosphate => 3'-phosphoadenylyl sulfate + 4-nitrophenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712083", "l": "ALK mutants bind PI3KCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1592371", "l": "Initial activation of proMMP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68555", "l": "NADP(+) + UDP-N-acetyl-alpha-D-quinovosamine <=> H(+) + NADPH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046525", "l": "xylosylprotein 4-beta-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088134", "l": "PLK1 phosphorylates FOXM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14242", "l": "3-amino-4-hydroxybenzaldehyde + acetyl-CoA => 3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28027", "l": "[thioredoxin]-disulfide + dUDP + H2O => [thioredoxin]-dithiol + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061815", "l": "Met1-linked polyubiquitin deubiquitinase activity", "d": ["Catalysis of the hydrolysis of ubiquitin units from Met1-linked (or linear) polyubiquitin chains."], "t": []}, {"i": "REACT:R-HSA-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47027", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 3 A + 3 H2O <=> [DsrC protein]-S-sulfo-L-cysteine/L-cysteine + 3 AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76385", "l": "carnosine(in) + n H(+)(in) => carnosine(out) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70881", "l": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5159250", "l": "ATF7IP binds SETDB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022405", "l": "ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73647", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14628", "l": "[(1->4)-alpha-D-glucosyl](n) + [(1->6)-alpha-D-glucosyl](n+1) <=> [(1->4)-alpha-D-glucosyl](n+1) + [(1->6)-alpha-D-glucosyl](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59154", "l": "AMP + diphosphate + pseudomonoyl-CoA C => ATP + CoA + pseudomonate C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36439", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23809", "l": "(S)-scoulerine + S-adenosyl-L-methionine => (S)-tetrahydrocolumbamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25666", "l": "(2E)-geranyl diphosphate = beta-pinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53002", "l": "5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-hydroxy-5alpha-androstan-3-one + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61495", "l": "a sphingoid base + an ultra-long-chain fatty acyl-CoA <=> an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35336", "l": "H(+) + isopentadecanoyl-CoA + malonyl-CoA => 3-oxoisoheptadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73885", "l": "guanidine(in) => guanidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21912", "l": "CoA + H(+) + O2 + pyruvate = acetyl-CoA + CO2 + H2O2", "d": [], "t": []}, {"i": "EC:1.2.3.6", "l": "\"pyruvate oxidase (CoA-acetylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29188", "l": "succinate + ubiquinone-8 => fumarate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9020274", "l": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655827", "l": "Expression of 7-Dehydrocholesterol Reductase (DHCR7) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12471", "l": "avenacoside A + H2O <=> 26-desgluco-avenacoside A + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40675", "l": "L-threonine = 2-aminobut-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559414", "l": "Activated TLR2/4:TIRAP interacts with BTK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52896", "l": "2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin = 2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate", "d": [], "t": []}, {"i": "EC:6.3.5.12", "l": "\"Ni-sirohydrochlorin a,c-diamide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2900748", "l": "NOTCH1 HD+PEST domain mutants bind DLL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866269", "l": "ARRB bind GPCRs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030761", "l": "8-hydroxyquercitin 8-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-452100", "l": "SHC1 bound to IL2 receptor is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.202618949668349", "identifiers": [{"i": "GO:0016861", "l": "intramolecular oxidoreductase activity, interconverting aldoses and ketoses", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears."], "t": []}, {"i": "EC:5.3.1.-", "l": "\"Interconverting aldoses and ketoses\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018500", "l": "trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity", "d": ["Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37559", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482770", "l": "Release of platelet secretory granule components (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61151", "l": "myricetin 3-O-alpha-L-rhamnoside + UDP-alpha-D-glucose <=> H(+) + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52292", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41064", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4341070", "l": "PIAS4 SUMOylates PPARA with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10901", "l": "an aromatic L-alpha-amino acid + glyoxylate => an aromatic oxo-acid + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65741", "l": "2-oxoglutarate + nonyl sufate + O2 => CO2 + H(+) + nonanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2186780", "l": "Degradation of Ub-SMAD7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50349", "l": "alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein] => a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70709", "l": "6-sulfo-D-rhamnose => 6-sulfo-beta-D-quinovose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59107", "l": "a dolichyl beta-D-glucosyl phosphate + chenodeoxycholate <=> a dolichyl phosphate + beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43638", "l": "2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51672", "l": "glyoxal + H2O = glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2473186", "l": "FSTL3 binds Activin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788523", "l": "NUBPL transfers 4Fe-4S to Complex I subunits (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74446", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799431", "l": "TP53 binds HIPK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210309", "l": "Interaction of DAP12 and KIR2DS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38219", "l": "(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49852", "l": "(3E)-octenoyl-CoA = (2E)-octenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34085", "l": "a (3S)-3-hydroxyacyl-CoA => a (3R)-3-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071859", "l": "neuropeptide F receptor binding", "d": ["Binding to a neuropeptide F receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63690", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950423", "l": "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-391936", "l": "EP1 receptor can bind PGE2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870732", "l": "PSGs bind proteoglycans and TGF-beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951676", "l": "RUNX3 binds TEADs and YAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3095889", "l": "MMACHC dealkylates RCbl (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58969", "l": "1-naphthaldehyde + H2O + O2 => 1-naphthoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16972", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose <=> dTDP-4-dehydro-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45885", "l": "12-methyloctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-methylheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71550", "l": "5-phosphomethyl-dUMP in DNA + glycine <=> 5-N(alpha)-glycyl-dTMP in DNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83656", "l": "TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29494", "l": "(2E,6E)-farnesyl diphosphate <=> cis-muurola-4(14),5-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102608", "l": "tetracenomycin B3 8-O-methyl transferase activity", "d": ["Catalysis of the reaction: tetracenomycin B3 + S-adenosyl-L-methionine = tetracenomycin E + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662823", "l": "PLK2, MAPK14 phosphorylate ADAM17 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.02616462956729", "identifiers": [{"i": "GO:0008395", "l": "steroid hydroxylase activity", "d": ["Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047011", "l": "2-dehydropantolactone reductase (A-specific) activity", "d": ["Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18186", "l": "adenosine + O2 => 5'-dehydroadenosine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052682", "l": "epi-cedrol synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = epi-cedrol + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74384", "l": "2 (S)-lactate(in) + prostaglandin E2(out) => 2 (S)-lactate(out) + prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.11", "l": "\"dextranase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975115", "l": "IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49559", "l": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] <=> H(+) + L-cysteinyl-[protein] + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003938", "l": "IMP dehydrogenase activity", "d": ["Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11607", "l": "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + n acetyl-CoA <=> [O(7),N-diacetyl-alpha-D-neuraminosyl-(2->8)](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708859", "l": "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944420", "l": "MAF1 binds the PTEN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380076", "l": "Tachykinin receptor 1 (NK1) binds to substance P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9692376", "l": "BCL2 binds BCL2 antagonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031719", "l": "type 2 cannabinoid receptor binding", "d": ["Binding to a type 2 cannabinoid receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68925", "l": "ATP + H(+) + hexanoate + NADPH => AMP + diphosphate + hexanal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696815", "l": "ELAC2 cleaves the 3' end of pre-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17306", "l": "H2O + N(omega),N(omega)-dimethyl-L-arginine => dimethylamine + L-citrulline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050505", "l": "hydroquinone glucosyltransferase activity", "d": ["Catalysis of the reaction: hydroquinone + UDP-D-glucose = H+ + hydroquinone O-beta-D-glucopyranoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380780", "l": "Activation of Src (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54883", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> (3R)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839031", "l": "Dimerization of cytosolic FGFR1 fusion proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693250", "l": "RHOD binds effectors at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3000348", "l": "RANBP2 SUMOylates SP100 with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373705", "l": "Caspase cleavage of DCC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44758", "l": "6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine => 2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77797", "l": "2-dehydro-D-glucose + an aliphatic amine => an (E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824402", "l": "ADAMTS13 variant does not cleave VWF multimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672978", "l": "RAF phosphorylates MAP2K dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878050", "l": "HIPK2 phosphorylates RUNX1 and EP300 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57401", "l": "3-O-acetylpapaveroxine + H2O => acetate + H(+) + narcotine hemiacetal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26002", "l": "D-arabinitol 1-phosphate + NAD(+) = D-xylulose 5-phosphate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.301", "l": "\"D-arabitol-phosphate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112396", "l": "Separation of elongating transcript from template (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51587", "l": "4-(trimethylamino)butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> crotonobetainyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801101", "l": "RABGGTA binds RABGGTB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25529", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42938", "l": "2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(32) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64509", "l": "acetyl-CoA + AH2 + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine => 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + 4 CO2 + 5 CoA + H2O + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50259", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49765", "l": "ethylenediaminetriacetate + FMNH2 + O2 => ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047328", "l": "acyl-phosphate-hexose phosphotransferase activity", "d": ["Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450346", "l": "activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55705", "l": "glycine + hydrogen sulfide + NAD(+) => ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8851804", "l": "Activated MET recruits GRB2-1:SOS1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2299677", "l": "SCARA5:ligand is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30752", "l": "ATP + CoA + hexadecanoate => AMP + diphosphate + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008442", "l": "3-hydroxyisobutyrate dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30241", "l": "n a quinol + n sulfur => n a quinone + n H(+) + n hydrogen sulfide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373342", "l": "CX3CR1 binds CX3CL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787447", "l": "TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858883", "l": "MITF-M binds the promoters of v-ATPase target genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66810", "l": "7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A => 5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.n4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52596", "l": "lithocholoyl-CoA + NAD(+) = 3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53415", "l": "(1R,4S)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> (4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46686", "l": "(22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2 => 3-oxochol-4-en-24-oyl-CoA + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49529", "l": "(ethylene terephthalate)(n) + H2O => (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78363", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-O-acyl-N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78635", "l": "3-oxohexacosanoyl-CoA + H(+) + NADH = (3R)-hydroxyhexacosanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54937", "l": "(2E)-decenoyl-[ACP] + H(+) + NADH => decanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15343", "l": "ADP + cob(II)yrinate a,c diamide + 5 H(+) + phosphate => ATP + Co(2+) + H2O + hydrogenobyrinate a,c-diamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35456", "l": "5alpha-cholest-7-en-3-one + 2 H(+) + 3 NADPH + 3 O2 => (25S)-Delta7-dafachronate + 4 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10455", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + O2 + reduced [NADPH--hemoprotein reductase] <=> (R)-dihydrocamalexate + 2 H(+) + 2 H2O + hydrogen cyanide + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40111", "l": "butanoyl-CoA + H2O = butanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56860", "l": "a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate = a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.277", "l": "\"2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.63", "l": "\"meprin B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18216", "l": "alpha-D-glucose 1-phosphate + CTP + H(+) <=> CDP-D-glucose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25331", "l": "(R)-carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2022399", "l": "ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76163", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 18-hydroxy-11-deoxycortisol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36776", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => alpha-L-Fuc-(1->2)-[alpha-D-Gal-(1->3)]-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61197", "l": "(E)-feruloyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + H(+) + myricetin 3-O-[(6-O-[(E)-feruloyl]-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49987", "l": "H(+) + jasmonate + NADPH + O2 <=> (1R,2R)-12-hydroxyjasmonate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033902", "l": "rRNA endonuclease activity", "d": ["Catalysis of the hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9716947", "l": "ESR1 binds ESR1 agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23503", "l": "H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) <=> 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58058", "l": "2-sulfinoacetaldehyde + L-alanine => hypotaurine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30808", "l": "L-pipecolate + NAD(+) => Delta(1)-piperideine-2-carboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665767", "l": "Activated FMNL3 binds G-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875661", "l": "GGA3 associates with activated MET receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14822", "l": "beta-L-arabinopyranose => L-ribulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63000", "l": "(11Z,14Z,17Z)-eicosatrienamide + H2O = (11Z,14Z,17Z)-eicosatrienoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18007", "l": "D-erythrulose + H(+) + NADPH => D-threitol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5610726", "l": "The IFT-A complex recruits TULP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449073", "l": "Caspase-3 cleaves pro-interleukin-16 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35110", "l": "3-nitrotyramine + H2O + O2 <=> 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28318", "l": "scutellarein + UDP-alpha-D-glucuronate = scutellarin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60158", "l": "ADP + D-galactose(in) + H(+) + phosphate => ATP + D-galactose(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662606", "l": "MT3 binds zinc (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10765", "l": "(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 => (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034028", "l": "5-(carboxyamino)imidazole ribonucleotide synthase activity", "d": ["Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H+ + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389970", "l": "Actin/tubulin:prefoldin complex associates with CCT/TriC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75148", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (-)-cyatha-3,12-diene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449978", "l": "IL7 binds IL7R:JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35488", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-2,3-dihydrogenistein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26457", "l": "NADP(+) + propanoyl-CoA <=> acryloyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192746", "l": "Binding of M1 to vRNP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72795", "l": "bilirubin IXalpha bis-beta-D-glucuronoside(out) = bilirubin IXalpha bis-beta-D-glucuronoside(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097216", "l": "guanosine tetraphosphate binding", "d": ["Binding to guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640195", "l": "RRAGA,B hydrolyzes GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372819", "l": "PCK2 phosphorylates OA to yield PEP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396399", "l": "Fibrillins bind BMPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22215", "l": "(2R,3R)-tartrate <=> (2R,3S)-tartrate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25762", "l": "ent-copalyl diphosphate <=> diphosphate + ent-isokaurene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204779", "l": "Interaction of Tie2 with Ang1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27692", "l": "ADP + dGTP => ATP + dGDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948066", "l": "K63polyUb-IRAK1 dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34664", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30269", "l": "L-ascorbate + L-dehydroascorbate => 2 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654573", "l": "Activated FGFR1 binds SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45323", "l": "H2O + N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine <=> H(+) + N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009941", "l": "RNASEL cleaves viral ssRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0008373", "l": "sialyltransferase activity", "d": ["Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696268", "l": "RND3 binds effectors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804425", "l": "TP53 binds POU4F2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27867", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O => (R)-glycerate + alpha-D-mannose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66779", "l": "ATP + H2O + uroporphyrin III(in) <=> ADP + H(+) + phosphate + uroporphyrin III(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983309", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549129", "l": "OCT1 transports organic cations into hepatic cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62940", "l": "H2O + N(4)-acetylcytosine = acetate + cytosine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63044", "l": "H2O + mevastatin = H(+) + mevinic carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27926", "l": "UMP(in) = UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15117", "l": "3'-dephospho-CoA + ATP = 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine", "d": [], "t": []}, {"i": "EC:2.4.2.52", "l": "\"triphosphoribosyl-dephospho-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709179", "l": "DPP4 binds DPP4 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63720", "l": "losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159431", "l": "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31627", "l": "10-deoxymethynolide + dTDP-alpha-D-desosamine = 10-deoxymethymycin + dTDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.277", "l": "\"10-deoxymethynolide desosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65117", "l": "2-oxoglutarate + aculene B + O2 => aculene A + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212004", "l": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23499", "l": "5-hydroxypentanoate + acetyl-CoA <=> 5-hydroxy-pentanoyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49914", "l": "(R)-carnitine(in) + O-propanoyl-(R)-carnitine(out) => (R)-carnitine(out) + O-propanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40892", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => H(+) + hexadecanoate + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23097", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP => 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77081", "l": "Formation of the CE:GMP intermediate complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11821", "l": "diphthamide-[translation elongation factor 2] + NAD(+) => H(+) + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043877", "l": "galactosamine-6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660910", "l": "Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36045", "l": "13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial => all-trans-8'-apo-beta-carotenal + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.132", "l": "\"chitosanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22856", "l": "(7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.150", "l": "\"salutaridinol 7-O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9761474", "l": "AMOT-2 binds CDH11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24215", "l": "5-(2-hydroxyethyl)-4-methylthiazole + ATP <=> 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23406", "l": "diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate => (2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41840", "l": "3-oxooctanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003911", "l": "DNA ligase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77261", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51200", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine = H2O + N-retinylidene-N-retinylphosphatidylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30087", "l": "(S)-2-hydroxyglutarate + FAD + H(+) = 2-oxoglutarate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31534", "l": "2-oxoglutarate + L-arginine + O2 <=> CO2 + N(omega)-hydroxy-L-arginine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016596", "l": "thienylcyclohexylpiperidine binding", "d": ["Binding to thienylcyclohexylpiperidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5617178", "l": "ATP2B4 binds to NOS1, inhibiting it (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.5", "l": "\"xylose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16048", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61273", "l": "H2O + L-2-aminopentanoate + O2 => 2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71336", "l": "chloride(out) + L-tryptophan(out) + 2 Na(+)(out) => chloride(in) + L-tryptophan(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825704", "l": "AKT3 phosphorylates TBX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47572", "l": "a ganglioside GD1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1b (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49169", "l": "8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine => 8,12-diethyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433471", "l": "Activation of RAS by p-KIT bound SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11678", "l": "D-ribonate + 2 H(+) + NADPH => D-ribose + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73422", "l": "L-glutamine(out) <=> L-glutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687088", "l": "PKA phosphorylates MAPKAPK5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36006", "l": "(S)-4-hydroxy-2-oxohexanoate <=> propanal + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662649", "l": "MT4 binds cadmium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110307", "l": "REV1 binds AP-dsDNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192065", "l": "CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37710", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9838321", "l": "PRKACA phosphorylates TFAM in the mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.-", "l": "\"In linear amides\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2681681", "l": "Tenascins C, R, (X, N) bind fibronectin matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033989", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity", "d": ["Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51499", "l": "a sphingoid base + ATP <=> a sphingoid 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33665", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701537", "l": "p-Y705, S727 STAT3 dimer binds CD274 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952251", "l": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018679", "l": "dibenzothiophene-5,5-dioxide monooxygenase activity", "d": ["Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12353", "l": "L-gulono-1,4-lactone + O2 => H2O2 + L-xylo-hex-3-ulonolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061784", "l": "peptidoglycan N-acetylglucosaminidase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) from peptidoglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61159", "l": "3'-dephospho-CoA + GTP <=> CoA + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8959462", "l": "SAMD8 transfers phosphatidyl from PE onto C16DH CER (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876193", "l": "RIC1-RGP1 exchanges GTP for GDP on RAB6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381727", "l": "RAP1A exchanges GDP for GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25805", "l": "H2O + O2 + spermine => 3-aminopropanal + H2O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47168", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851011", "l": "TRIM27 polyubiquitinates PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48698", "l": "H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol => 1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46838", "l": "4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357445", "l": "PAK1-3 dimer disassociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54207", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 <=> 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64228", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71643", "l": "guanosine + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036285", "l": "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2002428", "l": "Removal of fibrillar collagen N-propeptides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30973", "l": "all-trans-lycopene => 7,7',9,9'-tetra-cis-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71396", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) => (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57835", "l": "5-oxopentanoate + H2O + NADP(+) <=> glutarate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602484", "l": "Activation of proMMP11 by FURIN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-111915", "l": "CAMK4 autophosphorylates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43416", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22120", "l": "CoA + GTP + succinate = GDP + phosphate + succinyl-CoA", "d": [], "t": []}, {"i": "EC:6.2.1.4", "l": "\"succinate--CoA ligase (GDP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37550", "l": "D-glucose 6-phosphate + NAD(+) <=> 3-dehydro-D-glucose 6-phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41502", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2545196", "l": "FN1 dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008269", "l": "JAK pathway signal transduction adaptor activity", "d": ["The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371422", "l": "ATP hydrolysis by HSP70 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32621", "l": "H(+) + NADPH + sepiapterin => L-threo-7,8-dihydrobiopterin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33213", "l": "2-demethylmenaquinol-7 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-heptaprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69699", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O = beta-D-glucose + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65290", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamine => CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514823", "l": "Fibrillin-1 degradation by ELANE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1461982", "l": "Alpha-defensin dimers multimerize to form a pore complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60441", "l": "H2O + methyl acetate => acetate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964274", "l": "G alpha (12) binds BTK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25608", "l": "2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O <=> 2-(3-methylsulfanyl)propylmalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50613", "l": "decanal + NADP(+) => (2E)-decenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156699", "l": "Inactivation of Wee1 kinase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42094", "l": "all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51290", "l": "(13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55146", "l": "[4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH => [(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482907", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192312", "l": "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65371", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O <=> a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73011", "l": "L-leucine(in) = L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43013", "l": "L-homocysteine => 2-aminobut-2-enoate + H(+) + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013144", "l": "RAC1 GAPs stimulate RAC1 GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002401", "l": "Association of procollagen type XVIII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047930", "l": "glucosaminate ammonia-lyase activity", "d": ["Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26527", "l": "a (3R)-3-hydroxyacyl-CoA => a (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035516", "l": "broad specificity oxidative DNA demethylase activity", "d": ["Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427337", "l": "MBD2 binds methylcytosine in chromatin (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102361", "l": "esculetin 4-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: esculetin + UDP-alpha-D-glucose = 4-O-beta-D-glucosyl-esculetin + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2186780", "l": "Degradation of Ub-SMAD7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75899", "l": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41196", "l": "1-hexadecanoyl-2-butanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65539", "l": "1,3,7-trimethylurate + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + theacrine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2064406", "l": "Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "52.19589381639782", "identifiers": [{"i": "GO:0022834", "l": "ligand-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63358", "l": "(S)-2-(C-substituted-aminomethyl)-4-acyl-1,3-thiazole-[protein] + H2O2 => (1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373705", "l": "Caspase cleavage of DCC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624948", "l": "KIF17 enters the cilium (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805740", "l": "SETD8 methylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44189", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate => 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69068", "l": "RFC dissociates after sliding clamp formation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551648", "l": "SUMOylation of TDG with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72652", "l": "1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2 => 1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654667", "l": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26458", "l": "ethylnitronate + FMNH2 + O2 = acetaldehyde + FMN + 2 H(+) + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57133", "l": "L-ascorbate + O2 + tyramine => (R)-octopamine + H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5578965", "l": "TNRC6A binds AGO2:miRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68635", "l": "3 H(+)(in) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H(+)(out) + NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803233", "l": "Dissociation of oncogenic RAS:RAF complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202344", "l": "Recruitment of ZAP-70 to phosphorylated ITAMs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39859", "l": "a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycerol = a triacyl-sn-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77609", "l": "3-hexadecanoyl-sn-glycero-1-phospho-(3'-hexadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol) => 2 3-hexadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164151", "l": "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46077", "l": "(2E)-eicosenoyl-CoA + H(+) + NADH => eicosanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62454", "l": "AMP + diphosphate + L-glutamyl-[peptidyl-carrier protein] => ATP + holo-[peptidyl-carrier protein] + L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688377", "l": "Defective pro-SFTPC does not translocate from ER membrane to multivesicle body (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22431", "l": "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 <=> 2 H2O + isopenicillin N", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395412", "l": "Phosphorylation of SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65125", "l": "benzoyl-CoA + ethanol => benzyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018808", "l": "RAC3 binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66602", "l": "2 dopamine quinone + 2 H2O => 2 dopamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667914", "l": "ALK binds ligand midkine (MDK) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45989", "l": "3,17-dihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMNH2 + O2 => 3,4,17-trihydroxy-9,10-secoandrost-1,3,5(10)-triene-9-one + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24753", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite => 3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57540", "l": "a 5'-end NTP-ribonucleotide-RNA + H2O = a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.243", "l": "\"acyl-Kdo2-lipid IVA acyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65240", "l": "(11Z)-octadecenoyl-CoA + H2O = (11Z)-octadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140612", "l": "DNA damage sensor activity", "d": ["A molecule that recognises toxic DNA structures, for example, double-strand breaks or collapsed replication forks, and initiates a signaling response."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.42", "l": "\"guanosine-diphosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-168947", "l": "Ligand binds to TLR10 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043770", "l": "demethylmenaquinone methyltransferase activity", "d": ["Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090489", "l": "tryptophan N-monooxygenase activity", "d": ["Catalyzes the multi-step reaction: L-tryptophan + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-(indol-3-yl)acetaldehyde oxime + CO2 + 2 H+ + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25635", "l": "H(+) + S-adenosyl-L-homocysteine + syringetin => laricitrin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694605", "l": "nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180630", "l": "Association of APOBEC3G with Gag (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9625487", "l": "PTK2 autophosphorylates downstream of EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76550", "l": "acetyl-CoA + D-glutamine <=> CoA + H(+) + N-acetyl-D-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48683", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) <=> a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54268", "l": "2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2 = (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.30", "l": "\"hypoxia-inducible factor-asparagine dioxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21590", "l": "H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH => N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-982792", "l": "Growth hormone receptor binds JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665009", "l": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640844", "l": "RNF146 binds RibC-AXIN:TNKS complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605717", "l": "GM2A binds and mobilizes ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847534", "l": "RAB43 hydrolyses GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51622", "l": "CO2 + dCTP + H2O => CTP + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222128", "l": "NOC2L binds TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44258", "l": "1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42031", "l": "NAD(+) + ursodeoxycholate <=> 7-oxolithocholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047333", "l": "dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity", "d": ["Catalysis of the reaction: ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + 2 H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49511", "l": "phosphinomethylmalate <=> 2-(phosphinatomethylidene)butanedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336420", "l": "DT fragment B transports DT fragment A from target cell endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388855", "l": "Prolactin-releasing hormone receptor binds PRH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44238", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5668932", "l": "PAK2 phosphorylates myosin regulatory light chain (MRLC) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37715", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine = 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354060", "l": "Translocation of RIAM to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687183", "l": "PRKDC phosphorylates DCLRE1C at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36114", "l": "gibberellin A1 + S-adenosyl-L-methionine <=> O-methyl gibberellin A1 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607747", "l": "TRAF6 binds MALT1 oligomers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61123", "l": "kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-111930", "l": "Adenylate cyclase produces cAMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31681", "l": "H2O2 + prosolanapyrone III => O2 + prosolanapyrone II", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70035", "l": "6-deoxotyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48164", "l": "epoxypheophorbide a + H2O = H(+) + red chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26047", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin II + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.173", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51272", "l": "(9Z)-octadecenoyl-CoA + glycine = CoA + H(+) + N-(9Z-octadecenoyl)glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158447", "l": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5689111", "l": "PARK2 autoubiquitinates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23244", "l": "propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + norspermidine + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.5.1.23", "l": "\"sym-norspermidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19336", "l": "H(+) + oxalyl-CoA <=> CO2 + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013158", "l": "CDC42 GDIs block activation of CDC42 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55026", "l": "(3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70844", "l": "L-arginine(in) + L-methionine(out) + Na(+)(out) => L-arginine(out) + L-methionine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534087", "l": "NMT1/2 transfer MYS to GNAT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61492", "l": "a sphingoid base + an ultra-long-chain fatty acyl-CoA = an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.298", "l": "\"ultra-long-chain ceramide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75879", "l": "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18440", "l": "4-CDP-2-C-methyl-D-erythritol + ATP <=> 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5686587", "l": "ABL1 phosphorylates RAD52 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22103", "l": "3,5-dibromo-4-hydroxybenzonitrile + 2 H2O <=> 3,5-dibromo-4-hydroxybenzoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36856", "l": "an N-acetyl-L-cysteine-S-conjugate + H2O => acetate + an S-substituted L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75444", "l": "heme b(in) => heme b(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033960", "l": "N-methyl nucleosidase activity", "d": ["Catalysis of the reaction: 7-methylxanthosine + H2O = 7-methylxanthine + H+ + ribofuranose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140359", "l": "PGG2 is reduced to PGH2 by PTGS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16530", "l": "ADP + H(+) + sulfate => adenosine 5'-phosphosulfate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602473", "l": "Autocatalytic activation of MMP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72691", "l": "Formation of the 43S pre-initiation complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63823", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) <=> H(+) + holo-[aryl-carrier protein] + petrobactin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33546", "l": "ergosteryl palmitate + H2O <=> ergosterol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28100", "l": "AMP + guanosine 3',5'-bis(diphosphate) => ATP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27449", "l": "a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.75", "l": "\"diacylglycerol diphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12209", "l": "4-methylumbelliferyl acetate + H2O => 4-methylumbelliferone + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42256", "l": "H(+) + hexanoyl-CoA + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621366", "l": "SYK binds to p-Y65,Y76-FCER1G (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2247512", "l": "Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10235", "l": "5,6-dihydrouridine 5'-phosphate + diphosphate <=> 5,6-dihydrouracil + 5-phospho-alpha-D-ribose 1-diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42650", "l": "(2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+) => (2,5-ethylene furandicarboxylate)(n) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.83", "l": "\"monoterpene epsilon-lactone hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1295632", "l": "PPA2A dephosphorylates SPRY2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64125", "l": "H2O + N-hexadecanoyl-L-phenylalanine => hexadecanoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20488", "l": "(S)-scoulerine + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-cheilanthifoline + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73145", "l": "CoA(in) + FAD(out) => CoA(out) + FAD(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33789", "l": "3-keto-beta-D-galactose + beta-D-glucose => 3'-ketolactose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195275", "l": "Phosphorylation of APC component of the destruction complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46201", "l": "5alpha-androstane-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] => 5alpha-androstane-3beta,6alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865498", "l": "KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784189", "l": "JAKs bind LIFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9749253", "l": "Formation of MCM2-7 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9698408", "l": "PTPRJ dephosphorylates active FLT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19360", "l": "H(+) + L-proline betaine + NADPH + O2 <=> formaldehyde + H2O + N-methyl-L-proline + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48417", "l": "a ganglioside GA2 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GM2 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018617", "l": "4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity", "d": ["Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990362", "l": "butanol dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: butan-1-ol + NAD+ = butanal + H+ + NADH."], "t": []}, {"i": "RHEA:33199", "l": "butan-1-ol + NAD(+) = butanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9620456", "l": "sGC stimulators bind sGC:NO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9859163", "l": "DBT transfers BCAA to CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41351", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296244", "l": "SUCNR1 binds SUCCA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592436", "l": "Initial activation of proMMP9 by MMPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70418", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + H2O <=> (3,5-dihydroxyphenyl)acetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11673", "l": "chorismate + L-glutamine => 4-amino-4-deoxychorismate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25975", "l": "H2O + N(8)-acetylspermidine + O2 <=> 4-acetamidobutanal + H2O2 + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10768", "l": "(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 = (4S)-2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-481009", "l": "Exocytosis of platelet dense granule content (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24993", "l": "L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051720", "l": "DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12937", "l": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.23", "l": "\"1-acylglycerophosphocholine O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53141", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686578", "l": "Activated ATM phosphorylates ABL1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047262", "l": "polygalacturonate 4-alpha-galacturonosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78382", "l": "L-cysteinyl-[protein] + S-nitroso-CoA <=> CoA + S-nitroso-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72106", "l": "Na(+)(out) + O-propanoyl-(R)-carnitine(out) <=> Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048249", "l": "high-affinity phosphate transmembrane transporter activity", "d": ["Enables the transfer of phosphate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654511", "l": "FGFRL1 dimer binds FGFs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1222491", "l": "Lactoferrin scavenges iron ions (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610766", "l": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113402", "l": "Formation of DSIF:NELF:early elongation complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55768", "l": "all-trans-retinoate + UDP-alpha-D-glucuronate = all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030976", "l": "thiamine pyrophosphate binding", "d": ["Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.n10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692480", "l": "ATP13A2 transports cations from cytosol to lysosomal lumen (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49476", "l": "2 H2O + L-1-piperideine-6-carboxylate + NAD(+) = H(+) + L-2-aminoadipate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51934", "l": "2 Fe(II)-[cytochrome c3] + thiosulfate => 2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0099529", "l": "neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential", "d": ["Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955748", "l": "RUNX1 binds the SOCS3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8857565", "l": "Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000048", "l": "peptidyltransferase activity", "d": ["Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33069", "l": "(4R)-hydroxysphinganine + phosphate => (4R)-hydroxysphinganine 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665315", "l": "ERBB2 T733I does not bind tesevatinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987120", "l": "JAK1 binds IFNLR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41947", "l": "[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP <=> [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70047", "l": "2-oxoadipate + L-kynurenine = H2O + kynurenate + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74921", "l": "a (2E)-enoyl-[ACP] + AMP + H(+) => a (2E)-2-fatty-enoyl-AMP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43801", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22680", "l": "dCTP + H(+) + H2O = dUTP + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.13", "l": "\"dCTP deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59175", "l": "hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase] <=> AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45795", "l": "2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 <=> [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57241", "l": "glyoxal + GMP => N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33161", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+) => H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018750", "l": "biuret amidohydrolase activity", "d": ["Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939870", "l": "UCMA gene expression is stimulated by RUNX2 and SP7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61750", "l": "H(+) + stevioside + UDP => rubusoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71637", "l": "phosphate(out) + 2 thiosulfate(in) => phosphate(in) + 2 thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78115", "l": "a 1,2-diacyl-3-(9Z,12Z-octadecadienoyl)-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base = a 1,2-diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61431", "l": "cis-trans-nepetalactol + NAD(+) <=> cis-trans-nepetalactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36691", "l": "octadecanoyl-CoA + sphing-4-enine = CoA + H(+) + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43184", "l": "S-adenosyl-L-methionine + uridine(2843) in 25S rRNA = H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.312", "l": "\"25S rRNA (uracil(2843)-N(3))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12181", "l": "anthranilate + S-adenosyl-L-methionine => H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74918", "l": "a (2E)-enoyl fatty acid + ATP + H(+) <=> a (2E)-2-fatty-enoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43252", "l": "1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67579", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O <=> [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49766", "l": "ethylenediaminediacetate + FMN + glyoxylate + H(+) + H2O => ethylenediaminetriacetate + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482604", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448673", "l": "Formation of caspase-1 p10/p20 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77275", "l": "2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9619355", "l": "CaMKK autophosphorylates in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045340", "l": "mercury ion binding", "d": ["Binding to a mercury ion (Hg2+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11965", "l": "5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O => 5alpha-cholestane-3beta,5,6beta-triol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210289", "l": "Recruitment of SYK to p-DAP12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15794", "l": "(4Z,15Z)-bilirubin IXalpha + NADP(+) => biliverdin IXalpha + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38009", "l": "6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine => 6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050015", "l": "kievitone hydratase activity", "d": ["Catalysis of the reaction: kievitone hydrate = H2O + H+ + kievitone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11492", "l": "H(+) + O-phospho-L-threonine = (R)-1-aminopropan-2-yl phosphate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.81", "l": "\"threonine-phosphate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29906", "l": "ATP + D-ribose(out) + H2O <=> ADP + D-ribose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76413", "l": "2',3'-cGAMP(in) + n H(+)(in) => 2',3'-cGAMP(out) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76681", "l": "H(+) + NADH + sulfoacetyl-CoA => CoA + NAD(+) + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.179", "l": "\"brassinosteroid 6-oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27542", "l": "methanol + N,N-dimethyl-4-nitrosoaniline = 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43818", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14261", "l": "(E)-sinapoyl-CoA + D-glucono-1,5-lactone = 6-O-[(E)-sinapoyl]-D-glucono-1,5-lactone + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.132", "l": "\"glucarolactone O-hydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031807", "l": "H1 histamine receptor binding", "d": ["Binding to a H1 histamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661240", "l": "DCXR tetramer reduces L-xylulose to xylitol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050387", "l": "urethanase activity", "d": ["Catalysis of the reaction: H2O + H+ + urethane = CO2 + ethanol + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60462", "l": "(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out) => (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46370", "l": "a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57947", "l": "H(+) + H2O2 + harderoheme III <=> CO2 + 2 H2O + heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71293", "l": "(R)-carnitine(in) + chloride(in) + 2 Na(+)(in) => (R)-carnitine(out) + chloride(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664881", "l": "NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691150", "l": "TFR2 dimer binds 2xholoTF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418925", "l": "ADORA2A,B bind Ade-Rib (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50061", "l": "ATP + glycochenodeoxycholate(in) + H2O => ADP + glycochenodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047758", "l": "ATP:2-methylpropanoate phosphotransferase activity", "d": ["Catalysis of the reaction: 2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73535", "l": "CDP(out) + UTP(in) = CDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44055", "l": "alpha,alpha-trehalose + hexadecanoyl-CoA <=> 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638075", "l": "HEXB cleaves the terminal GalNAc from DS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033905", "l": "xylan endo-1,3-beta-xylosidase activity", "d": ["Catalysis of the random hydrolysis of (1->3)-beta-D-glycosidic linkages in (1->3)-beta-D-xylans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69173", "l": "Joining of adjacent Okazaki fragments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8847880", "l": "CYTH proteins bind ARF1:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672957", "l": "PP2A dephosphorylates KSR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78475", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49296", "l": "keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + L-sorbose 1-phosphate(in)", "d": [], "t": []}, {"i": "EC:2.7.1.206", "l": "\"protein-N(pi)-phosphohistidine--L-sorbose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-927813", "l": "p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46260", "l": "an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59016", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) = CO2 + cycloeucalenone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68518", "l": "beta-acoradiene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50940", "l": "L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) = cyclo(L-phenylalanyl-L-leucyl) + H(+) + tRNA(Leu) + tRNA(Phe)", "d": [], "t": []}, {"i": "EC:2.3.2.20", "l": "\"cyclo(L-leucyl-L-phenylalanyl) synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55776", "l": "all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate = all-trans-4-hydroxy-4-O-(beta-D-glucuronide)-retinoate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47532", "l": "chenodeoxycholate + NAD(+) = 3-oxochenodeoxycholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855221", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1973956", "l": "NEDD4 binds ERBB4jmAcyt1s80 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73147", "l": "adenosine 3',5'-bisphosphate(out) + FAD(in) = adenosine 3',5'-bisphosphate(in) + FAD(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011748", "l": "IL9R binds JAK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682992", "l": "KDM4A,B bind H4K20Me2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71088", "l": "17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) => 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64937", "l": "dGTP + H2O => dGDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13103", "l": "H2O + trans-urocanate => 4-imidazolone-5-propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10988", "l": "H2O + nitrous oxide = 2 e(-) + 2 H(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203613", "l": "depalmitoylation of eNOS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70197", "l": "ADP + H(+) + nicotinate-adenine dinucleotide 3'-phosphate => ATP + deamido-NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9854415", "l": "ACAT1 tetramer acetylates IDH2 dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36661", "l": "novobiocin + phosphate => carbamoyl phosphate + descarbamoylnovobiocin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18797", "l": "a 3'-hydroxy,5'-unsubstituted flavanone + O2 + reduced [NADPH--hemoprotein reductase] = a 3',5'-dihydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72185", "l": "mRNA polyadenylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34301", "l": "2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate => 2'-deamino-2'-hydroxyneamine + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-937034", "l": "IRAK1 phosphorylates Pellino (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59666", "l": "D-cellopentaono-1,5-lactone + H2O2 => D-cellopentaose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-500717", "l": "Activation of GRIK3 homomer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005130", "l": "granulocyte colony-stimulating factor receptor binding", "d": ["Binding to a granulocyte colony-stimulating factor receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9724745", "l": "PLG(20-810) binds aprotinin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019828", "l": "aspartic-type endopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of aspartic-type endopeptidases."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008807", "l": "carboxyvinyl-carboxyphosphonate phosphorylmutase activity", "d": ["Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-350318", "l": "Caspase-mediated cleavage of vimentin at TNLD (429) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534359", "l": "CatSper Channel Mediated Calcium Transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45137", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate => 7,8-dihydroneopterin 3'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9824894", "l": "TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30308", "l": "7-methylxanthine + H(+) + NADPH + O2 => formaldehyde + H2O + NADP(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2267372", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853745", "l": "RET binds GFRA1,GFRA3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8952620", "l": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444171", "l": "Receptor FFAR2 binds carboxylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69819", "l": "H(+) + hypotaurine + NADPH + O2 = H2O + NADP(+) + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42631", "l": "S-adenosyl-L-methionine + uridine(747) in 23S rRNA <=> 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23310", "l": "2-O-[(E)-sinapoyl]-D-glucarate + CoA => (E)-sinapoyl-CoA + D-glucarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39050", "l": "26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62248", "l": "chloroacetaldehyde + H2O + NADP(+) = chloroacetate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662466", "l": "XYLB phosphorylates D-xylulose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694485", "l": "ABHD3 hydrolyses LPC(14:0) to 1AGPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53313", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031814", "l": "P2Y4 nucleotide receptor binding", "d": ["Binding to a P2Y4 nucleotide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24084", "l": "all-trans-zeaxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48829", "l": "H(+) + NADPH + O2 + resorcinol => benzene-1,2,4-triol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49301", "l": "D-maltose(out) + N(pros)-phospho-L-histidyl-[protein] => alpha-maltose 6'-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174174", "l": "Phosphorylation of the Emi1 DSGxxS degron by Plk1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30076", "l": "CMP + H2O => cytosine + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46514", "l": "an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O => an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-381668", "l": "cAMP activates EPAC1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102523", "l": "2-chloroacrylate reductase activity", "d": ["Catalysis of the reaction: (S)-2-chloropropanoate + NADP = 2-chloroacrylate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16147", "l": "CMP-N-glycoloyl-beta-neuraminate + 2 Fe(III)-[cytochrome b5] + H2O => CMP-N-acetyl-beta-neuraminate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-982765", "l": "Growth hormone forms dimers and oligomers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799722", "l": "TP53I3 oxidoreductase generates unstable semiquinones (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56576", "l": "a globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine = a globoside Gb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935988", "l": "OCLN (Occludin) gene expression is stimulated by RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222485", "l": "TrxB reactivates TrxA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16894", "l": "pyridine + S-adenosyl-L-methionine => N-methylpyridinium + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51331", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 10-hydroperoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452097", "l": "Recruited STAT5 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018565", "l": "dihydroxydibenzothiophene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380508", "l": "Translocation of NuMA to the centrosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749215", "l": "MCM8 binds CDC6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163214", "l": "Electron transfer from reduced cytochrome c to molecular oxygen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55618", "l": "a carotenoid epsilon-end group => a carotenoid psi-end group", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1011600", "l": "Rabenosyn-5 connects  Rab5 to VPS-45 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25523", "l": "an acyl-CoA + pseudotropine <=> CoA + H(+) + O-acylpseudotropine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130641", "l": "Translocation of TGN-lysosome vesicle to lysosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.353", "l": "\"demethylluteothin O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008949", "l": "oxalyl-CoA decarboxylase activity", "d": ["Catalysis of the reaction: H+ + oxalyl-CoA = CO2 + formyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928607", "l": "p-EPHs bind VAV2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3341294", "l": "Superoxide reduces cytochrome c (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58095", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24776", "l": "H2O + pheophorbide a = C-13(2)-carboxypyropheophorbide a + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77201", "l": "3beta-sulfo-5-cholenate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3beta-hydroxy-5-cholenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852136", "l": "UBA1 conjugates ubiquitin to UBA1 in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754130", "l": "CDK4 inhibitors bind CDK4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5688797", "l": "ATXN3 family cleave Ub chains (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428664", "l": "SGPP1,2 dephosphorylate sphingoid-1-phosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.940402076938994", "identifiers": [{"i": "GO:0004896", "l": "cytokine receptor activity", "d": ["Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30723", "l": "A + 2 ADP + H(+) + NH4(+) + 2 phosphate = AH2 + 2 ATP + H2O + hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38119", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694494", "l": "AACS ligates CoA-SH to ACA, forming ACA-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786155", "l": "POLN binds ICL-DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57887", "l": "diphosphate + H2O + Na(+)(in) <=> H(+) + Na(+)(out) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839110", "l": "HTRA2 degrades NDUFA13 (GRIM-19) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46250", "l": "(14Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380294", "l": "Loss of C-Nap-1 from centrosomes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58737", "l": "H2O + TTP => 5-methyl-UMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53109", "l": "2-hydroxyestrone + S-adenosyl-L-methionine => 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32446", "l": "all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12707", "l": "[protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine => [protein]-L-isoaspartate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.26", "l": "\"prolyl oligopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191972", "l": "27-hydroxycholesterol is 7alpha-hydroxylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72676", "l": "eIF3 and eIF1A bind to the 40S subunit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944257", "l": "Association of procollagen type XXIV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2169046", "l": "Degradation of TGF-beta receptor complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807872", "l": "Active ARF recruits coatomer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.5", "l": "\"aldehyde dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2179407", "l": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78405", "l": "(+)-penichrysol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25348", "l": "D-tyrosyl-tRNA(Tyr) + H2O => D-tyrosine + tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55523", "l": "dimethylallyl diphosphate + 3 isopentenyl diphosphate <=> 3 diphosphate + nerylneryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66521", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35038", "l": "4-aminobutanoate(in) <=> 4-aminobutanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987230", "l": "p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13723", "l": "H(+) + testolate => H2O + testololactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14568", "l": "(11Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] <=> 3-oxo-(13Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.323347803118935", "identifiers": [{"i": "GO:0003777", "l": "microtubule motor activity", "d": ["A motor activity that generates movement along a microtubule, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70644", "l": "D-proline(out) + H(+)(out) => D-proline(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787737", "l": "CSF3R binds CSF3 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791082", "l": "Expression of Calreticulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32899", "l": "1,8-cineole + O2 + reduced [flavodoxin] = 2-endo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}, {"i": "EC:1.14.14.133", "l": "\"1,8-cineole 2-endo-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.80", "l": "\"fructan beta-fructosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31289", "l": "acryloyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + oxidized [electron-transfer flavoprotein] + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-917730", "l": "Cargo Recognition And Sorting (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209120", "l": "Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40555", "l": "dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2 = dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.187", "l": "\"L-evernosamine nitrososynthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75333", "l": "chloride(in) + D-methionine(in) + 2 Na(+)(in) => chloride(out) + D-methionine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047906", "l": "fucosterol-epoxide lyase activity", "d": ["Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = acetaldehyde + desmosterol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38901", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in) => a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75577", "l": "11-O-acetylcyathin A3 + AH2 => 11-O-acetylcyathatriol + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6804099", "l": "HMGB1 binds LTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33232", "l": "H2O2 + heme b => heme d cis-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9022314", "l": "HIPK2 phosphorylates MECP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0009486", "l": "cytochrome bo3 ubiquinol oxidase activity", "d": ["Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21978", "l": "[thioredoxin]-dithiol + adenosine 5'-phosphosulfate => [thioredoxin]-disulfide + AMP + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35518", "l": "4'''-demalonylsalvianin + malonyl-CoA <=> CoA + salvianin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71313", "l": "chloride(in) + L-alanine(in) + 2 Na(+)(in) => chloride(out) + L-alanine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49329", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spheroidene => 2-hydroxyspheroidene + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443439", "l": "c-Src binds Raf1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71995", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + preaspterpenacid acid I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27636", "l": "2,5-didehydro-D-gluconate + H(+) + NADPH => 5-dehydro-D-gluconate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56880", "l": "a 3beta-hydroxy-Delta(5)-steroid + NADP(+) = a 3-oxo-Delta(5)-steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021523", "l": "WWP2 ubiquitinates NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63797", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O => C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16112", "l": "ATP + beta-D-fructose 6-phosphate <=> ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9827999", "l": "SOX17 binds the TET2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622668", "l": "FOXO3,(FOXO1) bind BBC3 gene first intron (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592314", "l": "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8964284", "l": "BTK in active Gq-BTK complex is activated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78444", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol => a 1,2-diacylglycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32519", "l": "(2E)-geranyl diphosphate + S-adenosyl-L-methionine = (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.255", "l": "\"geranyl diphosphate 2-C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420980", "l": "Activation of Ca permeable AMPA receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9038029", "l": "27-hydroxysterol binds ESR1, ESR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71892", "l": "dGMP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17590", "l": "2,2'-iminodipropanoate + H2O + NAD(+) => H(+) + L-alanine + NADH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76845", "l": "H(+) + NADH + NH4(+) + octanal => H2O + NAD(+) + octylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004329", "l": "formate-tetrahydrofolate ligase activity", "d": ["Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983703", "l": "p-6Y-SYK phosphorylates BLNK (SLP65) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140619", "l": "DNA strand exchange activator activity", "d": ["Binds to and increases a DNA strand exchange activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59351", "l": "D-maltobiono-1,5-lactone + H2O <=> D-maltobionate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.35", "l": "\"barrierpepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33542", "l": "ergosteryl ester + H2O <=> a carboxylate + ergosterol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71859", "l": "glycochenodeoxycholate(out) = glycochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050645", "l": "limonoid glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30818", "l": "beta-nicotinamide D-ribonucleotide + H2O <=> beta-nicotinamide D-riboside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23146", "l": "2 H(+) + N-acetyl-D-glucosaminate + NADH => H2O + N-acetyl-alpha-D-glucosamine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73474", "l": "D-ornithine(in) + L-ornithine(out) <=> D-ornithine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034216", "l": "high-affinity thiamine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0018488", "l": "aryl-aldehyde oxidase activity", "d": ["Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161950", "l": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15608", "l": "H2O + L-serine O-sulfate <=> H(+) + NH4(+) + pyruvate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40032", "l": "ent-copalyl diphosphate + H2O => diphosphate + ent-manool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41558", "l": "(3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + CO2 + succinate => 2-oxoglutarate + L-arginyl-[ribosomal protein uL16] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76361", "l": "n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(in) => n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684008", "l": "NBN binds KPNA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25250", "l": "H(+) + 2 pyruvate => (2S)-2-acetolactate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60356", "l": "H2O + N-octanoylanthranilate = anthranilate + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31572", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2 => CO2 + H2O + NADP(+) + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36048", "l": "A + D-glyceraldehyde + H2O => (R)-glycerate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55144", "l": "[(3S,4R)-4-(6-methylheptanoyl)-5-oxooxolan-3-yl]methyl phosphate + NADP(+) = [4-(6-methylheptanoyl)-5-oxo-2H-furan-3-yl]methyl phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265783", "l": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73288", "l": "(2S)-naringenin + S-adenosyl-L-methionine => (2S)-naringenin 4'-methyl ether + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18953", "l": "L-erythro-7,8-dihydrobiopterin + NADP(+) = H(+) + NADPH + sepiapterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56512", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68268", "l": "dUMP + formaldehyde + H(+) + NADPH = dTMP + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52755", "l": "H2O + isomaltose <=> beta-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1214188", "l": "PRDM9 trimethylates histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29649", "l": "alpha-D-glucose 1-phosphate + alpha-maltotetraose => alpha-maltopentaose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848751", "l": "PTK6 binds AKT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202245", "l": "Phosphorylation of TBSMs in LAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79096", "l": "an L-alpha-amino acid + glycocholate => an N-choloyl-L-alpha-amino acid + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852362", "l": "GTSE1 binds CDKN1A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9710354", "l": "GSDME (1-270) binds cardiolipin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35065", "l": "NH4(+) + pyrazine-2-carboxylate => H2O + pyrazinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-76031", "l": "2 H2O2 => O2 + 2 H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754974", "l": "ADK phosphorylates RBV (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15079", "l": "(R)-pantetheine + CO2 => H(+) + N-[(R)-pantothenoyl]-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10157", "l": "dihydrochelirubine + O2 + reduced [NADPH--hemoprotein reductase] => 12-hydroxydihydrochelirubine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0045510", "l": "interleukin-24 binding", "d": ["Binding to interleukin-24."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57040", "l": "aldehydo-D-apiose = D-apiofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49262", "l": "D-galactose 6-phosphate(in) + L-histidyl-[protein] => D-galactose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474210", "l": "Collagen type III degradation by MMP14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23803", "l": "H2O + L-methionine <=> 2-oxobutanoate + methanethiol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9634861", "l": "NPAS4 binds ARNT2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57833", "l": "5-oxopentanoate + H2O + NADP(+) => glutarate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47573", "l": "a ganglioside GD1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GT1b (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693243", "l": "RHOD translocates to the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672958", "l": "YWHAB dimer dissociates from KSR1:MARK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39562", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA <=> (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202967", "l": "Caspase mediated cleavage of alpha-II-Fodrin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035501", "l": "MH1 domain binding", "d": ["Binding to a MH1 (MAD homology 1) protein domain. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993802", "l": "HLCS biotinylates PC:Mn2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3247847", "l": "WLS is endocytosed to the early endosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60327", "l": "L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419223", "l": "5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + adenosine 5'-diphosphate + orthophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465934", "l": "11cROL translocates from Muller cells to cone photoreceptor cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0005048", "l": "signal sequence binding", "d": ["Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58087", "l": "1-(13Z-docosenoyl)-glycerol + H2O <=> (13Z)-docosenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18826", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose => [(1->6)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55067", "l": "4-methylpentanoyl-CoA + H2O <=> 4-methylpentanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52111", "l": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA <=> 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844006", "l": "SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428273", "l": "SPHK1 phosphorylates sphingoid (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14543", "l": "cholate + CoA + H(+) => choloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341072", "l": "SUMOylation of RARA with SUMO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60902", "l": "an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine => a cytidine in RNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371586", "l": "Dissociation of cytosolic HSF1:HSP90 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18785", "l": "A + gibberellin A12 aldehyde + H2O = AH2 + gibberellin A12 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-192137", "l": "THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37690", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol <=> 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873917", "l": "Translocation of STAT1 dimer to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162873", "l": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-430341", "l": "Mig-2 recruits Migfilin to the cell-ECM adhesions (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086059", "l": "voltage-gated calcium channel activity involved SA node cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626223", "l": "C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1067651", "l": "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45891", "l": "12-methyltridecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(11-methyldodecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12340", "l": "L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71373", "l": "epitestosterone 17-sulfate(in) + 2 Na(+)(in) => epitestosterone 17-sulfate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27328", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-dehydro-6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753676", "l": "NAT1,2 acetylate APAP-Cys to APAP-Mer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016617", "l": "4-oxoproline reductase activity", "d": ["Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53875", "l": "CTP + D-ribose 5-phosphate + H(+) <=> CDP-D-ribose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40011", "l": "(+)-copalyl diphosphate + H2O = diphosphate + manool", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9859148", "l": "BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58895", "l": "3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 <=> adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62992", "l": "H2O + tetradecamide = NH4(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38600", "l": "NADP(+) + nicotinate => nicotinamide + nicotinate-adenine dinucleotide phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9758088", "l": "UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698762", "l": "FLT3 ITD- and STAT5-dependent NOX4 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14550", "l": "(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O => 2-oxopent-4-enoate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14686", "l": "A + a primary alcohol => AH2 + an aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18973", "l": "2-oxoglutarate + deacetoxyvindoline + O2 = 4-O-deacetylvindoline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37819", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16885", "l": "2 (4E,15E)-bilirubin IXalpha C8-beta-D-glucuronoside = (4Z,15Z)-bilirubin IXalpha + bilirubin IXalpha bis-beta-D-glucuronoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3341296", "l": "GPX7,8 catalyze peroxidation of P4HB (PDI) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6803890", "l": "SFN dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070573", "l": "metallodipeptidase activity", "d": ["Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14929", "l": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15925", "l": "dihydrobunolol + NADP(+) = bunolol + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.160", "l": "\"dihydrobunolol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9821235", "l": "HCFC1, HCFC2 bind the MLL1:MEN1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.26", "l": "\"cancer procoagulant\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237129", "l": "Acireductone is created (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-189062", "l": "lactose + H2O => D-glucose + D-galactose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72798", "l": "bilirubin IXalpha bis-beta-D-glucuronoside(out) <=> bilirubin IXalpha bis-beta-D-glucuronoside(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65452", "l": "ethanol + hexanoyl-CoA = CoA + ethyl hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428918", "l": "Dissociation of the TP:G13 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40069", "l": "3-hydroxy-6-carboxyhexanoyl-CoA + H(+) => 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22533", "l": "(2E)-octenedioyl-CoA + H2O => (3S)-hydroxyoctanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061770", "l": "translation elongation factor binding", "d": ["Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42737", "l": "guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine => H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12237", "l": "H2O + NADP(+) + nicotinate => 6-hydroxynicotinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032358", "l": "oxidized pyrimidine DNA binding", "d": ["Binding to a DNA region containing an oxidized pyrimidine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-162657", "l": "Inactivation of Myt1 kinase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508513", "l": "PTK2B binds JAK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684836", "l": "CLEC1B dimer binds PDPN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56788", "l": "apo-[corrinoid adenosyltransferase] + cob(II)alamin = cob(II)alamin-[corrinoid adenosyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67968", "l": "H2O + presqualene diphosphate = H(+) + phosphate + presqualene phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928628", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55556", "l": "a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70573", "l": "argininosuccinate <=> fumarate + arginine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45867", "l": "16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA <=> 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21782", "l": "AH2 + cyclohex-2-enone => A + cyclohexanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23674", "l": "3-dehydroquinate + a quinol => a quinone + L-quinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67280", "l": "(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione = (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57910", "l": "5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP => ATP + L-glutamyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72248", "l": "(R)-noradrenaline + S-adenosyl-L-methionine => (R)-normetanephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-354077", "l": "Integrin alphaIIb beta3 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25854", "l": "an (11Z)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042913", "l": "group A colicin transmembrane transporter activity", "d": ["Enables the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810235", "l": "RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43446", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+) => 1,2-ditetradecanoyl-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67068", "l": "AH2 + chermesin D methyl ester = A + asnovolin J", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62507", "l": "3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein] <=> 3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837087", "l": "FASTK binds MT-ND6 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46658", "l": "5beta-androstane-3,17-dione + NADP(+) => androst-4-ene-3,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691167", "l": "CUL1, SKP1, FBXL5 bind (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-877187", "l": "P2X7 mediates loss of intracellular K+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63953", "l": "a sphingoid 1-phosphate + H2O => a sphingoid base + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21206", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester => a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10820", "l": "D-threo-isocitrate = D-erythro-isocitrate", "d": [], "t": []}, {"i": "EC:5.1.2.6", "l": "\"isocitrate epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66868", "l": "3 O2 + quiannulatene + 3 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + quiannulatate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11729", "l": "cyclopentanol + NAD(+) => cyclopentanone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034814", "l": "7,8-dihydroxy benzo(a)pyrene dioxygenase activity", "d": ["Catalysis of the reaction: benzo(a)pyrene-cis-7,8-dihydrodiol + O2 = cis-4-(7-hydroxypyren-8-yl)-2-oxobut-3-enoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69578", "l": "CO2 + N(6)-[(R)-S(8)-glutaryldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] => 2-oxoadipate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25548", "l": "(+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.32", "l": "\"levopimaradiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23510", "l": "(7R)-7-aminocephalosporanate + glutarate => (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140563", "l": "UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity", "d": ["Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140696", "l": "factor V -> factor Va + factor V activation peptide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592316", "l": "Initial activation of proMMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65227", "l": "(1R,2R)-1,2-dihydronaphthalene-1,2-diol + NADP(+) <=> H(+) + NADPH + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75851", "l": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43924", "l": "NAD(+) + pregnenolone = H(+) + NADH + pregn-5-ene-3,20-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2467775", "l": "Autocleavage of ESPL1 (Separase) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67272", "l": "1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + 9-hydroxy-(10E,12Z)-octadecadienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69005", "l": "Cdc6 protein is phosphorylated by CDK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24336", "l": "a carboxylate + ATP + CoA = AMP + an acyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937728", "l": "SRC phosphorylates RUNX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49223", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + CTP <=> CMP-beta-3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9686922", "l": "PELI1 binds activated RIPK1:RIPK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9768930", "l": "NPAS4 binds MDM2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34042", "l": "2-oxoglutarate + neamine <=> 6'-oxoparomamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25693", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) <=> CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12917", "l": "3alpha(S)-strictosidine + H2O = D-glucose + strictosidine aglycone", "d": [], "t": []}, {"i": "EC:3.2.1.105", "l": "\"3alpha(S)-strictosidine beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62479", "l": "3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] <=> 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635854", "l": "GLI2,3 are degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047756", "l": "chondroitin 4-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694442", "l": "CNIH2,3 bind GRIA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54748", "l": "ATP + CoA + firefly L-luciferin = AMP + diphosphate + L-firefly luciferyl-CoA", "d": [], "t": []}, {"i": "EC:6.2.1.52", "l": "\"L-firefly luciferin--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42136", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + an N-acylsphinganine = a 1,2-diacyl-sn-glycerol + an N-acylsphinganine-1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41512", "l": "L-ornithine + NADH + O2 = H2O + N(5)-hydroxy-L-ornithine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34660", "l": "C30 botryococcene + S-adenosyl-L-methionine => 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007882", "l": "IL1F10 is cleaved (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45101", "l": "6-demethylmitomycin B + S-adenosyl-L-methionine => mitomycin B + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71417", "l": "3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out) => 3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10848", "l": "an [alpha-factor](in) + ATP + H2O = ADP + an [alpha-factor](out) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.4.2.7", "l": "\"ABC-type alpha-factor-pheromone transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3322429", "l": "XIAP monoubiquinates TLE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78507", "l": "a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427570", "l": "Group 3 - Selective Cl- transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451418", "l": "Pellino ubiquitinates IRAK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14544", "l": "choloyl-CoA + H2O <=> cholate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56332", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + H2O = AMP + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031981", "l": "NTRK2-phosphorylated FRS2 binds PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1363303", "l": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21704", "l": "H2O + L-tyrosine = NH4(+) + phenol + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.99.2", "l": "\"tyrosine phenol-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71514", "l": "phylloquinone(out) <=> phylloquinone(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13910", "l": "phosphate + urate D-ribonucleoside => alpha-D-ribose 1-phosphate + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35938", "l": "2 ATP + L-proline + L-tryptophan <=> 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34376", "l": "4-guanidinobutanamide + H2O => 4-guanidinobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72188", "l": "H(+)(out) + sucrose(out) => H(+)(in) + sucrose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24462", "l": "acetyl-[ACP] + CO2 => H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047551", "l": "2-oxoaldehyde dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56172", "l": "FMN + O2 = 8-demethyl-8-formylriboflavin 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74662", "l": "N-acetyl-D-glucosamine + UTP <=> H(+) + N-acetyl-D-glucosamine 6-phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33123", "l": "all-trans-heptaprenyl diphosphate = (R)-tetraprenyl-beta-curcumene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.130", "l": "\"tetraprenyl-beta-curcumene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30138", "l": "dodecanoyl-CoA + H2O <=> CoA + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936979", "l": "RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1237081", "l": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948775", "l": "MKRN1 polyubiquitinates PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9024993", "l": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17119", "l": "ADP + H(+) + N(5)-methyl-L-glutamine + phosphate => ATP + L-glutamate + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823966", "l": "EOMES, SMAD2,3, MIXL1 bind the GSC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73729", "l": "Formation of SL1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322019", "l": "Autoglucosylation of GYG2 complexed with GYS2-b (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168896", "l": "NS1 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9659680", "l": "ABCB1 transports xenobiotics out of the cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53332", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250616", "l": "botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39895", "l": "7-deoxyloganetate + UDP-alpha-D-glucose = 7-deoxyloganate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.323", "l": "\"7-deoxyloganetic acid glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102624", "l": "scutellarein 7-methyl ether 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine = ladanein + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11806", "l": "an aromatic carboxylate + 2 H(+) + NADH => an aromatic aldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396594", "l": "Phosphorylation of SLP-76 by p-SYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16817", "l": "6-phospho-D-gluconate + NADP(+) = 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693761", "l": "FA2H hydroxylates 1,2-saturated fatty acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199456", "l": "PTEN dephosphorylates PIP3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32299", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADH = 2 diphosphate + NAD(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102461", "l": "kaempferol 3-sophoroside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose = kaempferol 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9752951", "l": "LHX2, LDB1, and EBF1 bind Olfactory Receptor gene and intergenic olfactory enhancers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47652", "l": "D-ribitol 1-phosphate + H2O = phosphate + ribitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30851", "l": "beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193065", "l": "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78768", "l": "3''-dehydroorientin => 1,5-anhydro-D-erythro-hex-1-en-3-ulose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-561072", "l": "OCT3 mediates renal uptake of organic cations (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047769", "l": "arogenate dehydratase activity", "d": ["Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41896", "l": "(2E)-tetradecenoyl-[ACP] + H(+) + NADPH = NADP(+) + tetradecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632906", "l": "PRKCZ recruits RAS in response to estrogen stimulation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73569", "l": "DHODH:FMN oxidises (S)-DHO to orotate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228406", "l": "tetX HC transports tetX LC from target cell endosome membrane into cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12746", "l": "a 1,4-lactone + H2O => a 4-hydroxyacid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29310", "l": "FMNH2 + methanesulfonate + O2 <=> FMN + formaldehyde + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38841", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.65", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990576", "l": "G protein-coupled glucose receptor activity", "d": ["Combining with an extracellular glucose molecule and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55034", "l": "an N,N-dimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N-methylornithine lipid + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50247", "l": "17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] <=> 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67420", "l": "a glycerophospholipid + H2O = a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134822", "l": "DDX41 binds viral dsDNA  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23945", "l": "(E)-coniferol + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-(E)-coniferol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11695", "l": "NAD(+) + NADPH <=> NADH + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008909", "l": "isochorismate synthase activity", "d": ["Catalysis of the reaction: chorismate = isochorismate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30952", "l": "(2E,6E)-farnesyl diphosphate + H2O => alpha-eudesmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183052", "l": "CBL binds to GRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73579", "l": "(E,E)-piperoyl-AMP + CoA = (E,E)-piperoyl-CoA + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73297", "l": "7,8-dihydroxy-4'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 4',7,8-trihydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61058", "l": "H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase] => (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35122", "l": "(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O <=> bisdemethoxycurcumin + CO2 + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66811", "l": "5-aminopentanoate + acetyl-CoA + 17 H(+) + 7 malonyl-CoA + 11 NADPH <=> 7 CO2 + 8 CoA + 6 H2O + 11 NADP(+) + wortmanamide A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78206", "l": "D-valine + H2O + O2 <=> 3-methyl-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.886097586492113", "identifiers": [{"i": "GO:0003723", "l": "RNA binding", "d": ["Binding to an RNA molecule or a portion thereof."], "t": []}, {"i": "REACT:R-HSA-203922", "l": "Exportin-5 recognizes 3' overhang of pre-miRNA  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3827958", "l": "E-cadherin degradation by MMP9, KLK7 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38381", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664918", "l": "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013437", "l": "RHOD GAPs stimulate RHOD GTPase activity (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047798", "l": "cyclomaltodextrinase activity", "d": ["Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69983", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 3-dehydro-6-deoxoteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192010", "l": "5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851114", "l": "NPM1-ALK-dependent TYK2 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75491", "l": "25-hydroxyvitamin D3 sulfate(out) + n H(+)(out) = 25-hydroxyvitamin D3 sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55698", "l": "an N-acyl-sphingoid base + H(+) + mannosylinositol-1-phosphate => a mannosylinositol-1-phospho-N-acyl-sphingoid base + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109817", "l": "GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-742345", "l": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9688831", "l": "STUB1 ubiquitinates RIPK3 at K55, K363 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159796", "l": "Furin cleaves pro-factor IX to factor IX (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55965", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61070", "l": "19-O-acetylhorhammericine + CoA => acetyl-CoA + horhammericine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63375", "l": "an acyl-CoA + L-cysteinyl-[protein] <=> an S-acyl-L-cysteinyl-[protein] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50750", "l": "naphthalene-1,2,4,8-tetrol => H2O + juglone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140664", "l": "ATP-dependent DNA damage sensor activity", "d": ["A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786245", "l": "CARNS1 transforms ATP, L-His, b-Ala to CARN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19606", "l": "a chlorophyll + H2O => a chlorophyllide + H(+) + phytol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71872", "l": "(S)-3-hydroxybutanoate(out) + H(+)(out) => (S)-3-hydroxybutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41870", "l": "3-oxododecanoyl-[ACP] + CO2 + holo-[ACP] => decanoyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944229", "l": "Association of procollagen type IX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75607", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = plasmodiophorol B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51813", "l": "ATP(in) + CoA(in) + H(+)(out) + tetradecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + tetradecanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40730", "l": "1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid <=> a 1-acylglycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40454", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24207", "l": "acetyl phosphate + H(+) + sulfite <=> phosphate + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73226", "l": "(3S)-citramalate(in) + sulfate(out) <=> (3S)-citramalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050605", "l": "superoxide reductase activity", "d": ["Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60247", "l": "2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] <=> 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63787", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614591", "l": "Excess cysteine yields lanthionine and H2S (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29251", "l": "2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2995388", "l": "PP2A dephosphorylates BANF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019702", "l": "protein arginine N5-methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74971", "l": "L-leucine(out) + L-lysine(in) + Na(+)(out) = L-leucine(in) + L-lysine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78719", "l": "3-dehydro-alpha,alpha-trehalose + H2O = 3-dehydro-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39367", "l": "(2E,13Z,16Z,19Z,22Z)-octacosapentaenoyl-CoA + H(+) + NADPH = (13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31670", "l": "2-oxoglutarate + dTDP-3-amino-3,6-dideoxy-alpha-D-glucose <=> dTDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102365", "l": "taxusin 2-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: taxusin + NADPH + O2 + H+ = 2-alpha-hydroxytaxusin + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45450", "l": "dodecanoate + sphinganine => H2O + N-(dodecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69700", "l": "beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + H2O => beta-D-glucose + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67126", "l": "an alcohol + S-hydroxy-L-cysteinyl-[protein] => a hydroperoxide + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950340", "l": "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9674093", "l": "PDGFRs bind type I TKI (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824882", "l": "IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602242", "l": "Defective CYP2U1 does not omega-hydroxylate ARA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429992", "l": "PARN deadenylates mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60771", "l": "3 2-oxoglutarate + gibberellin A12 + 3 O2 <=> 3 CO2 + gibberellin A25 + H(+) + H2O + 3 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66291", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base <=> a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-D-mannosyl-alpha-1->6-inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353504", "l": "Insertion of correct bases opposite to the lesion by Pol eta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55808", "l": "a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36396", "l": "7-dehydrocholesterol + NADP(+) => 7-dehydrodesmosterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160915", "l": "Receptor-mediated uptake of HA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72247", "l": "(R)-noradrenaline + S-adenosyl-L-methionine = (R)-normetanephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77781", "l": "6-dehydro-D-glucose + CO2 + H(+) + succinate + sulfite => 2-oxoglutarate + 6-sulfo-D-quinovose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65466", "l": "2-methylbutyl butanoate + CoA => 2-methylbutan-1-ol + butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27421", "l": "(2E,6E)-farnesyl diphosphate = (3E,6E)-alpha-farnesene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.46", "l": "\"alpha-farnesene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51779", "l": "4-prenylphlorisobutanophenone + dimethylallyl diphosphate <=> deoxycohumulone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035379", "l": "carbon dioxide transmembrane transporter activity", "d": ["Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36885", "l": "(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76274", "l": "N,N-dimethylglycine(in) <=> N,N-dimethylglycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0031078", "l": "histone H3K14 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0004365", "l": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78577", "l": "(2E)-docosenoyl-CoA + H2O => (3S)-hydroxydocosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177927", "l": "PI3K binds to EGF:EGFR:GRB2:GAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66086", "l": "H2O + kynurenate + L-aspartate => L-kynurenine + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9626253", "l": "HSPA8 binds LAMP2a multimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58995", "l": "(E)-cinnamaldehyde + H2O + O2 <=> (E)-cinnamate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11733", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sophoraflavanone B => H(+) + H2O + leachianone G + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68441", "l": "beta-cryptoxanthin + O2 => (3R)-hydroxy-beta-ionone + all-trans-10'-apo-beta-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12757", "l": "dihydrozeatin + NADP(+) = H(+) + NADPH + zeatin", "d": [], "t": []}, {"i": "EC:1.3.1.69", "l": "\"zeatin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61171", "l": "quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9758661", "l": "UGT2B7,2B17,1A3 glucuronidates PRED metabolites (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9760094", "l": "SRXN1 reduces hyperoxidized PRDX1 dimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52016", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.15", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046083", "l": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140817", "l": "NAD+-histone H3S10 serine ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of ADP-ribose groups to the serine-10 or an equivalent residue of the N-terminal tail of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696415", "l": "PXLP-K278-ETNPPL tetramer hydrolyses PETA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73080", "l": "S-adenosyl-L-methionine + scutellarein => S-adenosyl-L-homocysteine + scutellarein 7-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-751024", "l": "The Ligand:GPCR:Gz complex dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60278", "l": "3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine => L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23280", "l": "acetyl-CoA + cysteamine = CoA + S-acetylcysteamine", "d": [], "t": []}, {"i": "EC:2.3.1.11", "l": "\"thioethanolamine S-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46221", "l": "androst-5-en-3beta,17beta-diol + NAD(+) => 3beta-hydroxyandrost-5-en-17-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30503", "l": "H2O + N-acetyl-L-glutamate 5-semialdehyde = acetate + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41999", "l": "a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose <=> a globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5138459", "l": "WNT5A:FZD4 is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757578", "l": "ALB binds PREDN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14235", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + CoA => a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140932", "l": "5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity", "d": ["Catalysis of the reaction: a 5'-end (N2,N2,N7-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + 2 H+ + N7-methyl-GMP. Can also use (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA as a substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2065550", "l": "SREBP1A,1C,2 binds Importin beta-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39523", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA = (2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983424", "l": "Budding of COPII coated vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46628", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH = androst-5-en-3beta,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55059", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> a 12-hydroxy-12-oxojasmonyl-L-alpha-amino acid + 3 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71012", "l": "L-isoleucine(in) + L-phenylalanine(out) => L-isoleucine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22693", "l": "3-hydroxybenzoate + H(+) + NADH + O2 => 2,5-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25238", "l": "ATP + CDP => ADP + CTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114697", "l": "Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76054", "l": "Binding of TFIIIC to TFIIIA:Type I Promoter complex  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77329", "l": "5-amino-2-oxopentanoate + L-alanine => L-ornithine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031925", "l": "pyridoxal transmembrane transporter activity", "d": ["Enables the transfer of pyridoxal from one side of a membrane to the other. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31057", "l": "estrone + H(+) + sulfate => estrone 3-sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71052", "l": "L-leucine(out) + L-methionine(in) => L-leucine(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170120", "l": "Translocation of Cdc25B to the cytoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004049", "l": "anthranilate synthase activity", "d": ["Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18160", "l": "ATP + pyruvate <=> ADP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836449", "l": "p-PKR dimer phosphorylates HIV tat (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9770145", "l": "Formation of the Spliceosomal Bact complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0055077", "l": "gap junction hemi-channel activity", "d": ["A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2032781", "l": "WWTR1 (TAZ) binds TEAD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34246", "l": "GTP + H(+) + Mo-molybdopterin <=> diphosphate + Mo-molybdopterin guanine dinucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681616", "l": "AP2 binds chlorpromazine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110352", "l": "Displacement of NTHL1 glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23453", "l": "2'-deoxyadenosine + ATP => ADP + dAMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660663", "l": "Caspase-8 cleaves IL1B precursor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.105", "l": "\"all-trans-retinol dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60112", "l": "(R)-3-(indol-3-yl)lactoyl-CoA = (E)-3-(indol-3-yl)acryloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44856", "l": "(9Z)-octadecenoyl-CoA + (R)-carnitine = CoA + O-(9Z)-octadecenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62938", "l": "2'-deoxycytidine + acetate + H(+) => H2O + N(4)-acetyl-2'-deoxycytidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088134", "l": "PLK1 phosphorylates FOXM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13354", "l": "4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CDP-L-ribitol => 4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n CMP + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58929", "l": "(3R,4R)-7,2',4'-trihydroxyisoflavanol => (6aR,11aR)-3,9-dihydroxypterocarpan + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45597", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51001", "l": "[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine => [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44017", "l": "2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) => 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507868", "l": "Aquaporins passively transport water into cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16507", "l": "4-hydroxybenzoate + pyruvate => chorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050622", "l": "glycine dehydrogenase (cyanide-forming) activity", "d": ["Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0048030", "l": "disaccharide binding", "d": ["Binding to a disaccharide. Disaccharides are sugars composed of two monosaccharide units."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59658", "l": "D-cellotriono-1,5-lactone + H2O2 => D-cellotriose + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48696", "l": "1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = H(+) + octanoate + octanoyl-3-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12164", "l": "3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.1", "l": "\"aryl sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28391", "l": "N(6)-(D-psicosyl)-L-lysine => N(6)-(D-fructosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42621", "l": "(Z)-2-methylureidoacrylate + H(+) + H2O => (Z)-2-methylaminoacrylate + CO2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656947", "l": "OGG1beta translocates to mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49028", "l": "(-)-bursehernin + O2 + reduced [NADPH--hemoprotein reductase] = (-)-5'-demethylyatein + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.131", "l": "\"bursehernin 5'-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592241", "l": "Expression of SSBP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73605", "l": "CMP(out) + CTP(in) => CMP(in) + CTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202709", "l": "JAM2 dimerises (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577237", "l": "KCNH2:KCNE transport K+ from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66653", "l": "(2E,6E)-farnesyl diphosphate => african-1-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23096", "l": "4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.49", "l": "\"hydroxymethylpyrimidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43509", "l": "2,5-diformylfuran + H2O => 2-(dihydroxymethyl)-5-formylfuran", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6814088", "l": "SYS1 binds AcM-ARFRP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16604", "l": "L-aspartate <=> fumarate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823934", "l": "OPTN binds TBK1 within the activated TLR4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-430028", "l": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171026", "l": "Guanine nucleotide exchange on RAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46234", "l": "(9Z,12Z,15Z)-hexadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z,12Z)-hexadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66107", "l": "3-(4-hydroxyphenyl)pyruvate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8866275", "l": "UBQLNs bind UIM-containing adaptor proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54426", "l": "4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide => L-aspartyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112436", "l": "Formation of Elongin complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39413", "l": "(2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418172", "l": "F2R binds ARRB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18671", "l": "adenine + D-ribose => adenosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202703", "l": "CD47 binds SIRP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1112538", "l": "Phosphorylated STAT1, STAT3 form dimers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13614", "l": "beta-D-fructose 6-phosphate + diphosphate => beta-D-fructose 1,6-bisphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73822", "l": "choline(in) + 2 H(+)(out) <=> choline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686685", "l": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373747", "l": "Phosphorylation of nephrin by FYN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375330", "l": "Connexin 45/Connexin 36 mediated neuronal gap junction communication (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46857", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + H(+) + NADPH => 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51137", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 2 O2 => (10,17S)-dihydroperoxy-(4Z,7Z,11Z,13Z,15E,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39328", "l": "(3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA => (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62530", "l": "dihydrodigoxin + 2 Fe(III)-[cytochrome c] => digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9685681", "l": "Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5655483", "l": "USP1 autocleavage (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936616", "l": "RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050533", "l": "5-phytase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981564", "l": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11470", "l": "3-methyl-2-oxobutanoate + L-isoleucine => (S)-3-methyl-2-oxopentanoate + L-valine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71565", "l": "5-acetylaminomethyl-dUMP in DNA + CoA + H(+) => 5-aminomethyl-dUMP in DNA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2106615", "l": "Removal of siRNA passenger strand (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-870437", "l": "USP9X (FAM) deubiquitinates SMAD4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12547", "l": "2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine <=> 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55781", "l": "all-trans-5,6-epoxyretinoate + UDP-alpha-D-glucuronate => all-trans-5,6-epoxyretinoyl-1-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9860264", "l": "TASL is phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351871", "l": "Caspase-mediated cleavage of Z0-2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38517", "l": "(9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) => 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19127", "l": "3-hydroxypyruvate + glycine => glyoxylate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033718", "l": "pyranose dehydrogenase (acceptor) activity", "d": ["Catalysis of the reactions: pyranose + acceptor = 2-dehydropyranose (or 3-dehydropyranose or 2,3-didehydropyranose) + reduced acceptor, and a pyranoside + acceptor = a 3-dehydropyranoside (or 3,4-didehydropyranoside) + reduced acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76441", "l": "19-oxo-11-deoxycorticosterone + 2 H2O + 2 oxidized [adrenodoxin] => 19-hydroxy-11-deoxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49243", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) <=> L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38261", "l": "glyoxylate + propanoyl-CoA => (2R,3S)-beta-methylmalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785607", "l": "FANCM binds FAAP24 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8874201", "l": "MBTPS2 (S2P) cleaves CREB3L3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809254", "l": "MTMR8 binds MTMR9 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44926", "l": "(R)-dihomocitrate + CoA + H(+) => 2-oxoadipate + acetyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8871265", "l": "YAP1 binds TEAD4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16295", "l": "(2S)-2-isopropylmalate => 2-isopropylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50413", "l": "L-leucyl-tRNA(Leu) + N-terminal L-glutamyl-[protein] => H(+) + N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9793901", "l": "Expression of DLL3 in paraxial mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41794", "l": "CoA + malonyl-[ACP] => holo-[ACP] + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13151", "l": "AH2 + NADP(+) => A + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34022", "l": "a 1-acylglycerol + H2O <=> a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.7.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22442", "l": "H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP => UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60762", "l": "CoA + jasmolin II => (1R,3R)-pyrethroyl-CoA + (Z,S)-jasmololone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22820", "l": "3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.62", "l": "\"xylosyl alpha-1,3-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678716", "l": "IDUA hydrolyses Heparan sulfate chain(1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-163090", "l": "Elongation Of The Telomeric Chromosome End (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13399", "l": "2 H(+) + hexanedioate + NADPH => 6-oxohexanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676109", "l": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654597", "l": "Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78076", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5634802", "l": "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72691", "l": "Formation of the 43S pre-initiation complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49752", "l": "2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate = CO2 + 2 H2O + NAD(+) + proviolacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1799326", "l": "Signal-containing nascent peptide translocates to endoplasmic reticulum (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61528", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base = a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64522", "l": "A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde => acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.27.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52457", "l": "testosterone + UDP-alpha-D-glucuronate => H(+) + testosterone 17-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671839", "l": "Phosphorylated STAT3 Dissociates from Leptin Receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419011", "l": "Transhomodimerization of Nectins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69173", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] => (2E)-2-butenoate + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008825", "l": "cyclopropane-fatty-acyl-phospholipid synthase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9823932", "l": "Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18256", "l": "(S)-malate + NADP(+) <=> CO2 + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418576", "l": "Dissociation of the P2Y purinoceptor 1:Gq complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39591", "l": "(3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA = (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33553", "l": "a fatty acid + sphinganine => an N-acylsphinganine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61511", "l": "peonidin + UDP-alpha-D-glucose <=> peonidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717215", "l": "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38557", "l": "a fatty acid + all-trans-retinol + H(+) => an all-trans-retinyl ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39386", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807868", "l": "GBF1 stimulates ARF nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685341", "l": "BCDX2 complex stabilizes RAD51 filament (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5684096", "l": "CDK2 phosphorylates RBBP8 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77287", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23828", "l": "2-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.274", "l": "\"2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654586", "l": "Activated FGFR1:p-FRS binds GRB2:SOS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55366", "l": "all-trans-nonaprenyl diphosphate + 6 diphosphate => (2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75988", "l": "a dicarboxylate(in) + indoxyl sulfate(out) => a dicarboxylate(out) + indoxyl sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005359", "l": "low-affinity glucose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21022", "l": "chorismate + phosphate => 5-O-(1-carboxyvinyl)-3-phosphoshikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.8", "l": "\"hypoxanthine phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21894", "l": "D-arabinono-1,4-lactone + H(+) + NADPH => D-arabinose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.140", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76613", "l": "4-hydroxy-3-methoxy-benzenemethanol + NADP(+) => H(+) + NADPH + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65656", "l": "A + cholest-1,4-dien-3-one + H2O = 25-hydroxycholest-1,4-dien-3-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788705", "l": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0097508", "l": "xanthine DNA N-glycosylase activity", "d": ["DNA N-glycosylase activity acting on deaminated guanine (xanthine)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28859", "l": "Ag(+)(in) + H(+)(in) = Ag(+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110229", "l": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32702", "l": "(2E,6E)-farnesyl diphosphate <=> beta-sesquiphellandrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34882", "l": "2 H2O + methyl 3-cyano-2-phenylpropanoate <=> 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036130", "l": "prostaglandin H2 endoperoxidase reductase activity", "d": ["Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810376", "l": "ING2 binds PI5P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508451", "l": "PTK2B is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614614", "l": "Cysteine is degraded to serine and H2S (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987039", "l": "JAK1 binds IL20RA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40650", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-688985", "l": "K63 polyubiquitinated RIP2 associates with the TAK1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72303", "l": "L-glutamate(in) + L-thyroxine(out) = L-glutamate(out) + L-thyroxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54540", "l": "H2O + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.8", "l": "\"ribosylpyrimidine nucleosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098650", "l": "peptidyl-proline 4-dioxygenase binding", "d": ["Binding to a peptidyl-proline 4-dioxygenase."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.112", "l": "\"oxaloacetate decarboxylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "50.084393658785821", "identifiers": [{"i": "GO:0005244", "l": "voltage-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008808", "l": "cardiolipin synthase activity", "d": ["Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75930", "l": "cyclohexylamine + H2O + NAD(+) <=> cyclohexanone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27820", "l": "2-dehydro-L-idonate + H(+) + NADH => L-idonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102794", "l": "cinnamaldehyde:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: cinnamaldehyde + O2 + H2O = H+ + trans-cinnamate + hydrogen peroxide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76691", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964241", "l": "G beta-gamma complex and PIP3 recruit BTK to membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033094", "l": "putrescine--2-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O. The enzymatic part of the reaction produces 4-aminobutanal that spontaneously cyclizes to form 1-pyrroline."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39210", "l": "3-oxohexacosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxyhexacosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67704", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(in) + ATP + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29113", "l": "NADP(+) + ubiquinol-8 => H(+) + NADPH + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014834", "l": "ROBO1,ROBO2 bind SLIT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264865", "l": "Caspase-mediated cleavage of Lamin A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212658", "l": "Tranport of L-Glutamate (mitochondrial matrix) to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130504", "l": "Cleavage of lip22 to lip10 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10229", "l": "citrate => cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204850", "l": "Interaction of Tie2 and Dok-2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9749197", "l": "ORC1 binds to H4K20me2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166363", "l": "TRAF6 binds to hp- IRAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3240957", "l": "Formation of PRC2-EZH2 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11834", "l": "H(+) + NADH + naphthalene-1,2-diol => (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004305", "l": "ethanolamine kinase activity", "d": ["Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H+ + phosphoethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56374", "l": "3-bromo-4,5-dihydroxybenzoate + 2 H2O + NADP(+) => 3,4-dihydroxybenzoate + bromide + 2 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74734", "l": "Re-integration of insulin receptor into plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950778", "l": "p-Y693-STAT4 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78936", "l": "a long-chain (3R)-hydroxyacyl-CoA + NAD(+) => a long-chain 3-oxo-fatty acyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450422", "l": "KSRP recruits RNA degradation activities (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33795", "l": "H2O + sucrose = alpha-D-glucose + beta-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236935", "l": "Proteasomal cleavage of substrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426566", "l": "Interaction of DAP12 and CLM7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75298", "l": "chloride(in) + sulfate(out) <=> chloride(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-451311", "l": "Activation of Ca-permeable Kainate receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34965", "l": "Na(+)(out) => Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-389611", "l": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395412", "l": "Phosphorylation of SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018745", "l": "epoxide hydrolase A activity", "d": ["Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9612509", "l": "SGK phosphorylates SRF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854408", "l": "APOBR dimer binds VLDLs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61843", "l": "brassicasterol + UDP-alpha-D-glucose <=> brassicasterol 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3204311", "l": "AOX1 oxidises PXL to PDXate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73370", "l": "D-xylose(out) + 2 Na(+)(out) <=> D-xylose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30307", "l": "7-methylxanthine + H(+) + NADPH + O2 = formaldehyde + H2O + NADP(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380233", "l": "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32912", "l": "sn-glycerol 3-phosphocholine(out) => sn-glycerol 3-phosphocholine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38670", "l": "sphing-4-enine 1-phosphate(in) <=> sphing-4-enine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57586", "l": "a 2-hydroxyflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a flavanone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61442", "l": "CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine => acetyl-CoA + S-(2-succino)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983700", "l": "SYK binds the activated BCR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71849", "l": "LDH tetramer reduces PYR to LACT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67428", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3782655", "l": "HDAC10 deacetylates histone (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008829", "l": "dCTP deaminase activity", "d": ["Catalysis of the reaction: dCTP + H2O = dUTP + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35973", "l": "diphosphate + fumitremorgin B => 12alpha,13alpha-dihydroxyfumitremorgin C + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53916", "l": "an acyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71670", "l": "PKM dephosphorylates PEP to PYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418553", "l": "cAMP degradation by Phosphodiesterases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15286", "l": "AMP + dimethylallyl diphosphate => diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42126", "l": "androsterone + H(+) + NADH => 5alpha-androstane-3alpha,17beta-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614271", "l": "Autocleavage of ADGRG6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75012", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate => 2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57574", "l": "7-deoxyloganetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7-deoxyloganetic aldehyde + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5691107", "l": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-203946", "l": "PDK isozymes phosphorylate PDHC subunit E1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984994", "l": "RUNX2 binds MAF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15682", "l": "2-hydroxy-5-carboxymethylmuconate semialdehyde + H2O + NAD(+) => (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13828", "l": "GDP-alpha-D-rhamnose + NAD(+) <=> GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70578", "l": "3',5'-cyclic UMP + H2O <=> H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944225", "l": "Association of procollagen type XVII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424480", "l": "PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0051717", "l": "inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity", "d": ["Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14370", "l": "2-phosphoglycolate + H2O => glycolate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29207", "l": "a menaquinol(in) + dimethyl sulfoxide(out) = a menaquinone(in) + dimethyl sulfide(out) + H2O(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37065", "l": "2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine => 2-thio-N(6)-dimethylallyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53272", "l": "5-dehydro-L-gluconate = keto-D-tagaturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69841", "l": "(22S)-22-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31500", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose => a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187405", "l": "MTMR4 binds phosphorylated SMAD2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430135", "l": "p-SLP-76 binds ADAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173680", "l": "Activation of C5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54903", "l": "(2E)-hexadecenoyl-[ACP] + H(+) + NADH <=> hexadecanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39769", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3149539", "l": "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9853368", "l": "FIRRM binds FIGNL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-210420", "l": "Ca2+ influx through voltage gated Ca2+ channels (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56385", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 => (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2990833", "l": "Conjugation of SUMO1 to UBA2:SAE1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9006850", "l": "IL21 receptor JAK phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.16", "l": "\"D-alanine--alanyl-poly(glycerolphosphate) ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46851", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) <=> 5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3900194", "l": "PIAS1 SUMOylates DDX5 with SUMO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36783", "l": "L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.5.1.108", "l": "\"2-(3-amino-3-carboxypropyl)histidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39283", "l": "a long-chain fatty acid(out) = a long-chain fatty acid(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44328", "l": "1-octanoylglycerol + H2O = glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26051", "l": "(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin III + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654697", "l": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19282", "l": "(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] => acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59951", "l": "H2O + prostaglandin F2alpha-CoA <=> CoA + H(+) + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665515", "l": "P2RX4,7 binds itself to form trimeric non-selective cation channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794840", "l": "Cipro is oxidized to oxo-Cipro (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444433", "l": "Cho transports from the extracellular space to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27678", "l": "ATP + dCDP = ADP + dCTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35876", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA => 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34529", "l": "(S)-3-amino-3-phenylpropanoate => L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27727", "l": "5-dehydro-4-deoxy-D-glucarate => 2-hydroxy-3-oxopropanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62185", "l": "peregrinol diphosphate => diphosphate + labd-13(16),14-diene-9-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-167429", "l": "The receptor:G-protein complex  binds GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5666070", "l": "RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10978", "l": "5,6-dihydroquinoline-2,5,6-triol + NAD(+) => H(+) + NADH + O2 + quinolin-2-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442387", "l": "ZIP8 mediates zinc influx into cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37557", "l": "kanosamine + phosphate => D-kanosamine 6-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5676596", "l": "TRAF3 binds BAFFR:BAFF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0070336", "l": "flap-structured DNA binding", "d": ["Binding to a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0015665", "l": "alcohol transmembrane transporter activity", "d": ["Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37979", "l": "2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-methionine = 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696947", "l": "USP47 deubiquitinates POLB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21117", "l": "D-maltose + phosphate => beta-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29806", "l": "ATP + H2O + L-valine(out) <=> ADP + H(+) + L-valine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12986", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052904", "l": "N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity", "d": ["Catalysis of the reaction: H2O + N(1)-acetylspermidine + O2 = 3-acetamidopropanal + H2O2 + putrescine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13326", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine => 3 H(+) + 2 NADH + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52833", "l": "1-hydroxylimonen-2-one + H(+) + NADPH + O2 => 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399998", "l": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63710", "l": "a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56782", "l": "(+)-sesamin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-piperitol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18443", "l": "5,6-dihydroxyindole + CO2 => D-dopachrome + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29626", "l": "alpha-maltopentaose + beta-maltose <=> alpha-maltohexaose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046919", "l": "pyruvyltransferase activity", "d": ["Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51239", "l": "GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n) <=> GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40227", "l": "3'-phosphoadenylyl sulfate + desulfo-A47934 = A47934 + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.36", "l": "\"desulfo-A47934 sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.15", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.22", "l": "\"aminopeptidase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0070529", "l": "L-tryptophan aminotransferase activity", "d": ["Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20792", "l": "ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)", "d": [], "t": []}, {"i": "EC:6.1.1.6", "l": "\"lysine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5669024", "l": "CD70 binds CD27 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2002440", "l": "Removal of fibrillar collagen C-propeptides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794572", "l": "ABCG2 transports Cipro from hepatic cell to extracellular space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9825790", "l": "p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6813626", "l": "LEAP2 binds bacteria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28474", "l": "D-glucarate(in) + H(+)(in) = D-glucarate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9759202", "l": "LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76072", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983144", "l": "Transport of Antigen peptide in to ER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70949", "l": "L-tryptophan(out) => L-tryptophan(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218811", "l": "DOCK180:ELMO binds CRK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47585", "l": "a ganglioside GT2 (d18:1(4E)) + UDP-alpha-D-galactose => a ganglioside GT1c (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-163756", "l": "Formation of fatty acid synthase (FAS) dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350458", "l": "RHOGAPP190 activates GTP hydrolysis by RHO1:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.5", "l": "\"cathepsin D\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047997", "l": "hydroxypyruvate decarboxylase activity", "d": ["Catalysis of the reaction: 3-hydroxypyruvate + H+ = CO2 + glycolaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9614564", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011984", "l": "KDM1A is recruited to MYC and BCL2 genes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195408", "l": "NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54923", "l": "13-cis-retinol + NADP(+) <=> 13-cis-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296024", "l": "Activation of ATP sensitive Potassium channels in neuroendocrine cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.7.1", "l": "\"pyruvate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69610", "l": "acetyl-CoA + N-terminal L-methionyl-[tubulin] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21862", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate => 3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65220", "l": "(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30546", "l": "(S)-carnitine + ATP + CoA <=> (S)-carnitinyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65779", "l": "chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5669158", "l": "NF2 binds PAK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35448", "l": "(1'S)-averantin + NADP(+) => H(+) + NADPH + norsolorinic acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62441", "l": "[(1->4)-alpha-D-galacturonosyl methyl ester](n) => 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate + [(1->4)-alpha-D-galacturonosyl methyl ester](n-1)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-350769", "l": "trans-Golgi Network Coat Activation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-997314", "l": "Dephosphorylation of JAK1 by SHP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9637638", "l": "esxA binds TLR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31298", "l": "(2E)-2-hydroxypenta-2,4-dienoate <=> 2-oxopent-4-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693602", "l": "ATM recognizes H2AFX-Nucleosomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23710", "l": "[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) => [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018498", "l": "2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity", "d": ["Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.51", "l": "\"ophiolysin\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32013", "l": "(+)-T-muurolol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17162", "l": "2,6-dioxo-6-phenylhexa-3-enoate + H2O => 2-oxopent-4-enoate + benzoate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50657", "l": "3-(2-methylsulfanyl)ethylmalate => 2-(2-methylsulfanyl)ethylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60578", "l": "Co(I)-[tetramethylammonium-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[tetramethylammonium-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40532", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73531", "l": "CTP(out) + UTP(in) = CTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696958", "l": "USP44 deubiquitinates CDC20 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42751", "l": "cytidine(967) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198756", "l": "ERK1/2 phosphorylates MSK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22005", "l": "ATP + L-seryl-[myosin light chain] => ADP + H(+) + O-phospho-L-seryl-[myosin light chain]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9834945", "l": "PINK1 phosphorylates Ub on MOM proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58633", "l": "N-tetradecanoyl-(2S)-hydroxyglycine => glyoxylate + tetradecamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985594", "l": "MYO9B inactivates RHOA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5666008", "l": "SCAI binds SRF:MKL1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8864036", "l": "PTPN12 dephosphorylates PDGFRB at Y1021 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56544", "l": "H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58729", "l": "adenosine in rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.364", "l": "\"protopanaxadiol-type ginsenoside 3-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709831", "l": "HSP90 binds TBK1 and IRF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-187688", "l": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41611", "l": "3'-phosphoadenylyl sulfate + alpha,alpha-trehalose <=> 2-O-sulfo-alpha,alpha-trehalose + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18605", "l": "1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.65", "l": "\"scyllo-inosamine 4-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58714", "l": "H(+) + H2O + NAD(+) + rifampicin para-naphthoquinone carboxamide => NADH + O2 + rifampicin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38312", "l": "carminomycin + S-adenosyl-L-methionine => daunorubicin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349455", "l": "Phosphorylation of MDM4 by ATM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56717", "l": "H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] => H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11330", "l": "diphosphate + neryl diphosphate => dimethylallyl diphosphate + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3791149", "l": "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430190", "l": "p-SLP-76 binds NCK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5334854", "l": "RAR:RXR binds SUMO-CRABP2:atRA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25654", "l": "(2S)-2-amino-3-oxobutanoate + H(+) => aminoacetone + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61201", "l": "acetyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] => CoA + myricetin 3-O-[(6-O-acetyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110251", "l": "Cleavage of hypoxanthine by MPG glycosylase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13247", "l": "glyoxylate + succinate => D-threo-isocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61489", "l": "cytidine(50) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40929", "l": "(9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+) => 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164832", "l": "ATPase synthesizes ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-844438", "l": "NLRP1 oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011543", "l": "DCA binds PDK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66481", "l": "gypsogenin + UDP-alpha-D-glucose => gypsogenin 28-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.1.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874470", "l": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.157", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62131", "l": "a 2'-deoxyribonucleoside 5'-phosphate + dGTP <=> a 2'-deoxyribonucleoside 5'-diphosphate + dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928647", "l": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59027", "l": "H2O + trihexadecanoylglycerol <=> dihexadecanoylglycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692749", "l": "CDC14A,B bind MAPK6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41136", "l": "1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O => 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74184", "l": "S-adenosyl-L-methionine + taxifolin => H(+) + S-adenosyl-L-homocysteine + taxifolin 4'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-532549", "l": "MPI isomerises Fru6P to Man6P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990583", "l": "phospholipase D activator activity", "d": ["Binds to and increases the activity of the enzyme phospholipase D."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879222", "l": "MDP:NLRP1 binds ATP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25538", "l": "diphosphate + ent-sandaracopimara-8(14),15-diene => ent-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-265429", "l": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67993", "l": "AH2 + trichloroethene => (Z)-1,2-dichloroethene + A + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799409", "l": "HIPK2 phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62291", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate <=> (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34652", "l": "3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine => 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674567", "l": "p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75309", "l": "D-serine(out) + L-glutamine(in) + Na(+)(in) => D-serine(in) + L-glutamine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949659", "l": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53512", "l": "(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O = (13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58804", "l": "5'-pApG-3' + H2O = 5'-ApG-3' + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65562", "l": "H2O + kynurenate + L-glutamate => 2-oxoglutarate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9629918", "l": "NEIL1 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35840", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA => a cardiolipin + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109636", "l": "Recognition and Binding of Core Promoter Elements by TFIID (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65207", "l": "(3R)-3-hydroxybutanoyl-CoA + H2O <=> (R)-3-hydroxybutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043792", "l": "enamidase activity", "d": ["Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O = 2-formylglutarate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50936", "l": "(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate = acetoacetyl-CoA + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.111", "l": "\"3-aminobutanoyl-CoA transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39448", "l": "(8Z,11Z,14Z,17Z)-3-oxoicosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731072", "l": "SARS-CoV-1 3a tetramer induces potassium efflux (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610732", "l": "GSK3 phosphorylates p-GLI3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56660", "l": "7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034874", "l": "thioacetamide S-oxide S-oxygenase activity", "d": ["Catalysis of the reaction: thioacetamide S-oxide + O2 + 2 H+ + 2 e- = thioacetamide S,S-dioxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2408551", "l": "SeMet is converted to AdoSeMet by MAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170685", "l": "Adenylaye cyclase increases the GTPase activity of G alpha-olf (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-141341", "l": "SMOX-3 oxidises SPN to SPM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668545", "l": "NIK autophosphorylates on T559 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008508", "l": "bile acid:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43124", "l": "guanosine(10) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) + N(2)-dimethylguanosine(10) in tRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.213", "l": "\"tRNA (guanine(10)-N(2))-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76440", "l": "19-hydroxy-11-deoxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] => 19-oxo-11-deoxycorticosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674019", "l": "BRAP binds KSR1:MARK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33341", "l": "CoA + H(+) + N-hexacosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43747", "l": "ATP + cytidine(34) in tRNA(Ile2) + L-lysine <=> AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56171", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-182986", "l": "CBL-mediated ubiquitination of CIN85 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050547", "l": "feruloyl-CoA hydratase/lyase activity", "d": ["Catalysis of the reaction: (E)-feruloyl-CoA + H2O = acetyl-CoA + vanillin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1504186", "l": "DVL recruits GSK3beta:AXIN1 to the receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032115", "l": "sorbose reductase activity", "d": ["Catalysis of the reaction: D-glucitol + NADP+ = L-sorbose + H+ + NADPH. The reaction may occur, to a minor extent, in the reverse direction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948569", "l": "miR-19b microRNA binds PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1253343", "l": "WWOX binds ERBB4s80 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-112385", "l": "Addition of nucleotides leads to transcript elongation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192331", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52416", "l": "3-dehydro-4-O-phospho-D-erythronate + H(+) = CO2 + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77138", "l": "1D-myo-inositol 1,2-bisphosphate + H2O <=> 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59270", "l": "AH2 + formaldehyde + L-lysyl-[protein] => A + H2O + N(6)-methyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73294", "l": "H(+)(out) + L-valine(in) <=> H(+)(in) + L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48394", "l": "a neolactoside IV(3)-alpha-NeuNAc,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+) => a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22956", "l": "1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.77", "l": "\"plasmanylethanolamine desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21645", "l": "ATP + glycerol => ADP + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938930", "l": "RUNX1 binds ELF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785178", "l": "LMF1,2 transport LIPC dimer from ER lumen to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2485148", "l": "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1011576", "l": "EHD proteins interact with Rabenosyn-5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9680443", "l": "ROCK1,2 bind ROCKi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16349", "l": "AH2 + chlorate = A + chlorite + H2O", "d": [], "t": []}, {"i": "EC:1.97.1.1", "l": "\"chlorate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797803", "l": "PTPRD binds SLITRK1-6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551648", "l": "SUMOylation of TDG with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1638053", "l": "HEXA cleaves the terminal GalNAc from keratan sulfate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16027", "l": "an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA => an anthocyanidin 3-O-beta-D-glucoside + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70329", "l": "4-methylsulfanyl-2-oxobutanoate + H(+) + NADH => (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12896", "l": "prostaglandin H2 <=> prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14131", "l": "3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH => cholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390291", "l": "acetyl-CoA + carnitine => acetylcarnitine + CoASH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029473", "l": "Branching and elongation of mother and daughter filaments (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0010242", "l": "oxygen evolving activity", "d": ["Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707586", "l": "FeHM oxidises LDL,HDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103047", "l": "methyl beta-D-glucoside 6-phosphate glucohydrolase activity", "d": ["Catalysis of the reaction: methyl beta-D-glucoside 6-phosphate + H2O = beta-D-glucose 6-phosphate + methanol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39913", "l": "(3S)-2-oxo-3-phenylbutanoate + L-glutamate => (2S,3S)-3-methylphenylalanine + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64141", "l": "an N-(fatty acyl)-L-asparagine + H2O => a fatty acid + L-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62730", "l": "(+)-malbrancheamide D + FADH2 => (+)-malbrancheamide B + bromide + FAD + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11071", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O <=> (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23726", "l": "4-pyridoxate + H(+) + H2O2 => H2O + O2 + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48265", "l": "H2O + S-sulfosulfanyl-L-cysteinyl-[SoxY protein] => H(+) + S-sulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59726", "l": "D-maltoheptaonate + H(+) => D-maltoheptaono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444572", "l": "Zinc is an agonist of GPR39 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813749", "l": "ALDH1A1 oxidises GA to DGA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71163", "l": "HPD dioxygenates HPP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49562", "l": "(R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate => D-sedoheptulose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53530", "l": "1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730842", "l": "PI3K associates with phosphorylated GAB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199404", "l": "CD40L binds CD40 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9845587", "l": "ST8SIA5 transfers Neu5Ac to gangliosides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9710963", "l": "p-STAT1dimer:KPNA1 binds KPNB1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10774", "l": "D-glucose + D-glucose 6-phosphate => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928632", "l": "ITSN1 exchanges GTP for GDP on CDC42, activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40517", "l": "(2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate => 6-deoxy-6-sulfo-D-fructose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23114", "l": "3-methylphenol + CO2 => 6-methylsalicylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21104", "l": "AH2 + cholesterol + O2 = 25-hydroxycholesterol + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.38", "l": "\"cholesterol 25-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971483", "l": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614631", "l": "Homocysteine is degraded to oxobutanoate and H2S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49754", "l": "CO2 + 2 H2O + NAD(+) + proviolacein => 2 H(+) + NADH + 2 O2 + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-399952", "l": "Phosphorylation of LIMK-1 by PAK (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53646", "l": "(+)-corvol ether B + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32736", "l": "1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine => 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102124", "l": "gibberellin A12 16alpha,17 epoxidase activity", "d": ["Catalysis of the reaction: gibberellin A12 + O2 + H+ + NAD(P)H = 16alpha, 17-epoxy gibberellin A12 + H2O + NAD(P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10366", "l": "(3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+) => 2-oxoglutarate + dodecanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112434", "l": "Formation of DSIF complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377644", "l": "Release of CSK from SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39460", "l": "(7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862300", "l": "LYZ binds bacterial peptidoglycan (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649963", "l": "ASIC3 channel blockers bind ASIC3 trimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36787", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-galactosamine = N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.40", "l": "\"UDP-N-acetylgalactosamine-undecaprenyl-phosphate N-acetylgalactosaminephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17656", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate <=> (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419644", "l": "Transphosphorylation of pLIMK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13369", "l": "dimethylallyl diphosphate = diphosphate + isoprene", "d": [], "t": []}, {"i": "EC:4.2.3.27", "l": "\"isoprene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16713", "l": "H2O + S-succinylglutathione = glutathione + H(+) + succinate", "d": [], "t": []}, {"i": "EC:3.1.2.13", "l": "\"S-succinylglutathione hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5679205", "l": "ULK1 phosphorylates Beclin-1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912407", "l": "NOTCH2 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-727768", "l": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804193", "l": "TP53 stimulates PRDM1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2201341", "l": "Endocytosis of TRAM (TICAM2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36019", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6806629", "l": "Formation of tonofilament bundles (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41628", "l": "geranylgeranyl diphosphate + H2O = cyclooctat-9-en-7-ol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.146", "l": "\"cyclooctat-9-en-7-ol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003827", "l": "alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404144", "l": "Parenchymal atROL translocates to HSCs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20382", "l": "androsterone + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938930", "l": "RUNX1 binds ELF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13672", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) <=> 3-hydroxy-2-methylpyridine-5-carboxylate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76841", "l": "H(+) + NADH + NH4(+) + propanal => H2O + NAD(+) + propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30792", "l": "dGTP + pyruvate => dGDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75972", "l": "NADP(+) + neomorphine => H(+) + NADPH + neomorphinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674496", "l": "Activated MAPKs phosphorylate MAP2K1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427998", "l": "Proton-coupled di- and tri-peptide cotransport (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14317", "l": "morphine + NAD(+) = H(+) + morphinone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38087", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.23", "l": "\"DNA-formamidopyrimidine glycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16655", "l": "2-dehydro-D-gluconate + H(+) + NADPH => D-gluconate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30582", "l": "H2O + O-phospho-L-threonine <=> L-threonine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950780", "l": "p-Y705-STAT3 binds p-Y693-STAT4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47785", "l": "cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046935", "l": "1-phosphatidylinositol-3-kinase regulator activity", "d": ["Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0140142", "l": "nucleocytoplasmic carrier activity", "d": ["Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026000", "l": "Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25212", "l": "H2O + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine <=> acetate + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027624", "l": "ALOX5 oxidises DHA to 7-HDHA (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.129", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-265301", "l": "Corticotropin cleavage from POMC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59271", "l": "A + H2O + N(6)-methyl-L-lysyl-[protein] <=> AH2 + formaldehyde + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22591", "l": "4-aminobutanal <=> 1-pyrroline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10096", "l": "a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.3.1.184", "l": "\"acyl-homoserine-lactone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33323", "l": "a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611751", "l": "β1,2-agonists bind ADRB1,2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69690", "l": "genistein 7-O-beta-D-glucoside + H2O <=> beta-D-glucose + genistein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5609665", "l": "CHUK, IKBKB and IKBKG form IKK complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40232", "l": "(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17038", "l": "indole-3-ethanol + NADP(+) => H(+) + indole-3-acetaldehyde + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234177", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46451", "l": "2 L-tyrosyl-tRNA(Tyr) <=> cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66163", "l": "hexanoyl-CoA + tyramine <=> CoA + H(+) + N-hexanoyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20452", "l": "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 <=> 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796065", "l": "AcK-NFE2L2 binds the ABCC3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59195", "l": "ATP + eicosanoate + H(+) <=> diphosphate + icosanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69630", "l": "N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111238", "l": "Formation of ADAR2  homodimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956045", "l": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170057", "l": "Formation of Cyclin B:Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944255", "l": "Association of procollagen type VII (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24845", "l": "cyclobis-(1->3)-alpha-D-isomaltosyl + 2 H2O => 2 isomaltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001565", "l": "phorbol ester receptor activity", "d": ["Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75147", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (-)-cyatha-3,12-diene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.206", "l": "\"(-)-cyatha-3,12-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55478", "l": "2 Fe(III)-[cytochrome b5] + H2O + N-acyl-4-hydroxyeicosasphinganine => an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9794523", "l": "SLC22A1 transports Cipro into renal cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871226", "l": "RET binds GFRA1,GFRA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5627072", "l": "RHOQ binds GOPC:CFTR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62673", "l": "a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine => an N(6)-methyl-2'-O-methyladenosine in U2 snRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77081", "l": "Formation of the CE:GMP intermediate complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58446", "l": "H(+) + N-terminal N-methyl-glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-homocysteine => N-terminal glycyl-L-lysyl-L-glutamyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61080", "l": "(+)-minovincinine + acetyl-CoA = (+)-echitovenine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388829", "l": "SHP2 phosphatase binds CTLA-4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27531", "l": "(2E,6E)-farnesyl diphosphate + H2O => (3S,6E)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29061", "l": "2 H(+)(out) + ubiquinol-8 => 2 H(+)(in) + H2 + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70585", "l": "1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA => a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9760402", "l": "ILF3 binds HOXC8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2529020", "l": "CK2 phosphorylates condensin I subunits (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41467", "l": "ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164840", "l": "ADP and Pi bind to ATPase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8939706", "l": "SCF(SKP2) polyubiquitinates RUNX2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9840429", "l": "DELE1(143-515) binds EIF2AK1 (HRI) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44645", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51894", "l": "acetate + cadaverine => H2O + N-acetylcadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23561", "l": "adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate => adenosylcob(III)alamin 5'-phosphate + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28311", "l": "beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + GDP-alpha-D-mannose => alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16673", "l": "3-phosphonopyruvate + H2O = H(+) + phosphate + pyruvate", "d": [], "t": []}, {"i": "EC:3.11.1.3", "l": "\"phosphonopyruvate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.51", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75824", "l": "Ubiquitination of Cyclin D1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102681", "l": "isoamylase (maltodextrin-releasing) activity", "d": ["Catalysis of the reaction: n H2O + a glycogen = n a maltodextrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78839", "l": "[DsrC protein]-dithiol + 2 a quinone + 2 H(+) + hydrogen sulfide = [DsrC protein]-trisulfide + 2 a quinol + H(+)", "d": [], "t": []}, {"i": "EC:1.8.5.10", "l": "\"[DsrC]-trisulfide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58197", "l": "H2O + N(6)-acetyl-L-lysyl-[histone] => acetate + L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19546", "l": "H2O + sn-glycerol 3-phosphocholine => glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49074", "l": "dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O => dibenzothiophene + 2 FMNH2 + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19923", "l": "D-ribulose 5-phosphate + H(+) + NADPH => D-ribitol 5-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14402", "l": "chlordecone alcohol + NADP(+) => chlordecone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8956639", "l": "RUNX1 binds YAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047001", "l": "2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140908", "l": "histone H3K122 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 122) = CoA + histone H3 N6-acetyl-L-lysine (position 122)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58155", "l": "H2O + NAD(+) + phosphonoacetaldehyde <=> 2 H(+) + NADH + phosphonoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9716947", "l": "ESR1 binds ESR1 agonists (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033969", "l": "gamma-glutamyl-gamma-aminobutyrate hydrolase activity", "d": ["Catalysis of the reaction: 4-(L-gamma-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47815", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-phosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-phosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432054", "l": "Aquaporin-1 passively transports water out of cell (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19498", "l": "H(+) + L-aspartate => beta-alanine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050344", "l": "trans-cinnamate 2-monooxygenase activity", "d": ["Catalysis of the reaction: trans-cinnamate + H+ + NADPH + O2 = 2-coumarate + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103064", "l": "inositol phosphorylceramide mannosyltransferase activity", "d": ["Catalysis of the reaction: a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1,6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37719", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17986", "l": "4-(trimethylamino)butanal + H2O + NAD(+) => 4-(trimethylamino)butanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418365", "l": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29825", "l": "chloride(out) => chloride(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651789", "l": "LIG1 bound to POLB ligates SSB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72722", "l": "eIF2 activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58499", "l": "choline + H(+) + NADH + O2 <=> glycolaldehyde + H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047903", "l": "fructose 5-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27288", "l": "diacetyl + H(+) + NADH => (S)-acetoin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102935", "l": "gypsogenin-UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenin = gypsogenin-28-beta-D-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033758", "l": "clavaminate synthase activity", "d": ["Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O; proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O; and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57988", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose = (20S)-ginsenoside F2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17635", "l": "an alcohol + D-glucuronate => a beta-D-glucuronoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77606", "l": "2 3-octadecanoyl-sn-glycero-1-phospho-(1'-sn-glycerol) <=> 3-octadecanoyl-sn-glycero-1-phospho-(3'-octadecanoyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31988", "l": "(S)-2,3-epoxysqualene => baruol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74656", "l": "ITP + N-acetyl-D-glucosamine => H(+) + IDP + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379464", "l": "COMT transfers Met to DOPAC to form HVA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080044", "l": "quercetin 7-O-glucosyltransferase activity", "d": ["Catalysis of the transfer of a glucosyl group from UDP-glucose to the 7-hydroxy group of a quercetin molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23765", "l": "diphosphate + L-serine => H(+) + O-phospho-L-serine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015026", "l": "coreceptor activity", "d": ["Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797268", "l": "Expression of HMOX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31613", "l": "H2O + rhodopin => 1,1'-dihydroxy-1,1',2,2'-tetrahydrolycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.244991688848543", "identifiers": [{"i": "GO:0016714", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor."], "t": []}, {"i": "EC:1.14.16.-", "l": "\"With reduced pteridine as one donor, and incorporation of one atom of oxygen\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16291", "l": "(R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH => (1R,2S)-ephedrine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63910", "l": "ADP + H(+) + phosphate + pravastatin(out) => ATP + H2O + pravastatin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.2.3", "l": "\"DNA 5'-3' helicase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9612509", "l": "SGK phosphorylates SRF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0070003", "l": "threonine-type peptidase activity", "d": ["Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9018814", "l": "RHOT1 hydrolyzes GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44452", "l": "3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19640", "l": "D-nopaline + H2O + NADP(+) <=> 2-oxoglutarate + H(+) + L-arginine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.211", "l": "\"endo-(1->3)-fucoidanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066778", "l": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222342", "l": "Hydroperoxyl enters the bacterium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799409", "l": "HIPK2 phosphorylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9853385", "l": "PPP1CC dephosphorylates PLK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56716", "l": "H2O + S-(2-sulfodisulfanyl)-L-cysteinyl-[SoxY protein] = H(+) + S-disulfanyl-L-cysteinyl-[SoxY protein] + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786881", "l": "TRNT1 polymerizes CCA at the 3' end of pre-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004119", "l": "cGMP-inhibited cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39339", "l": "(9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69216", "l": "(omega-1)-methyl-(3R)-hydroxy-fatty acyl-CoA + NADP(+) = (omega-1)-methyl-3-oxo-fatty acyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654422", "l": "Activated FGFR4 binds FRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66136", "l": "acetyl-CoA + tyramine = CoA + H(+) + N-acetyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70555", "l": "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36574", "l": "sphinganine + tetradecanoyl-CoA <=> CoA + H(+) + N-(tetradecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35213", "l": "dIMP + H(+) + phosphate => dIDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-196761", "l": "2xTPK1:Mg2+ phosphorylates THMN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-377640", "l": "Autophosphorylation of SRC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46458", "l": "5alpha-cholest-8-en-3beta-ol + NADP(+) => 5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22275", "l": "(20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] <=> (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78494", "l": "CMP-5'-(3-aminopropyl)phosphonate + NADPH + O2 <=> CMP-5'-(N-hydroxy-3-aminopropyl)phosphonate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68022", "l": "(2E)-geraniol + phosphate => (2E)-geranyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41446", "l": "glycine + 2 H(+) + phosphate => (1R)-(2-amino-1-hydroxyethyl)phosphonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9654525", "l": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41271", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78240", "l": "D-allo-threonine + H2O + O2 => (R)-3-hydroxy-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24147", "l": "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA <=> 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70441", "l": "a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9704248", "l": "CHRM4 binds CHRM4 antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2059926", "l": "NPHP4 protein binds LATS proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389158", "l": "CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418456", "l": "cGMP is degraded by PDEs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809521", "l": "BPIF binds bacteria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74933", "l": "a (3R)-3-isocyanyl-fatty acid + 3 CO2 + 2 H2O + 2 succinate => 2 2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847579", "l": "SCD5 desaturates ST-CoA to OLE-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625784", "l": "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22504", "l": "3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate", "d": [], "t": []}, {"i": "EC:2.8.2.26", "l": "\"quercetin-3-sulfate 3'-sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265545", "l": "NPC1L1-mediated phytosterol uptake (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814549", "l": "Pre-snRNA transcript initiation, Integrator binding, LEC binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748949", "l": "GUK1 phosphorylates 6TGMP to 6TGDP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58314", "l": "25-substituted-cholesterol + D-glucose => 25-substituted-cholesteryl beta-D-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13603", "l": "4-oxo-L-proline + H(+) + NADH => cis-4-hydroxy-L-proline + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30841", "l": "UDP-N-acetyl-beta-L-fucosamine => UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23116", "l": "4-hydroxybenzoate + ATP + CoA = 4-hydroxybenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.27", "l": "\"4-hydroxybenzoate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8870461", "l": "RABGGTA and RABGGTB bind (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43213", "l": "adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983707", "l": "SYK autophosphorylates at the activated BCR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165182", "l": "Phosphorylation of complexed TSC2 by PKB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20048", "l": "3-oxopropanoate + H2O + NAD(+) <=> 2 H(+) + malonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655289", "l": "Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70449", "l": "a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate => 2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20371", "l": "glycine betaine + H(+) + H2O2 => betaine aldehyde + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140485", "l": "5-aminolevulinic acid transmembrane transporter activity", "d": ["Enables the transfer of 5-aminolevulinic acid from one side of a membrane to the other."], "t": []}, {"i": "RHEA:64816", "l": "5-aminolevulinate(in) = 5-aminolevulinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.41", "l": "\"3-hydroxy-D-aspartate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425482", "l": "SLC4A1,2,3 exchanges HCO3- for Cl- (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13542", "l": "H2O + tetrathionate => H(+) + sulfate + sulfur + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0008119", "l": "thiopurine S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047685", "l": "amine sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160935", "l": "SMURF1 ubiquitinates RHOA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44631", "l": "L-dihydroanticapsin + NAD(+) <=> H(+) + L-anticapsin + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73163", "l": "FAD(out) + NAD(+)(in) = FAD(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76311", "l": "L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114600", "l": "Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50603", "l": "acetyl-CoA + N-terminal L-seryl-[histone H2A] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66052", "l": "indole-3-pyruvate + L-kynurenine = H2O + kynurenate + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53851", "l": "NAD(+) + taurocholate <=> 7-oxo-taurodeoxycholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352994", "l": "3-phosphoglycerate <=> 2-phosphoglycerate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17088", "l": "4-pyridoxate + A <=> 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51159", "l": "ATP + L-glutamate + tRNA(Glu) <=> AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424246", "l": "Tenascins C, R, (X, N) bind lecticans (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-448955", "l": "Phosphorylation of MEF2 proteins by p38 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942344", "l": "FOLR2 transports FOLA from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9840949", "l": "ARSA removes sulfate from SM3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59072", "l": "AH2 + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + A + cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate) + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.308", "l": "\"cytidylyl-2-hydroxyethylphosphonate methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339713", "l": "Misspliced GSK3beta mutants stabilize beta-catenin levels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161293", "l": "Tropoelastin forms aggregate globules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12881", "l": "ADP-alpha-D-glucose + sn-glycerol 3-phosphate = 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.213", "l": "\"glucosylglycerol-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047926", "l": "geranyl-diphosphate cyclase activity", "d": ["Catalysis of the reaction: geranyl diphosphate = (2S)-bornyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69718", "l": "(indol-3-yl)acetate + ATP + CoA <=> (indol-3-yl)acetyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43345", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+) => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47392", "l": "H2O + hexadecanoate ester = an aliphatic alcohol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061776", "l": "topological DNA co-entrapment activity", "d": ["A DNA binding activity in which a protein complex interacts with at least one DNA duplex to encircle the DNA molecules with a loose fitting ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8856951", "l": "PP2A demethylation by PPME1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605797", "l": "SMPD1 hydrolyzes SPHM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48067", "l": "a ganglioside GD1b (d18:1(4E)) + H2O <=> a ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140859", "l": "pterocarpan synthase activity", "d": ["Catalysis of the reaction: H2O + medicarpin = 4'-methoxyisoflavan-2',4,7-triol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3797226", "l": "Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40874", "l": "(9Z)-octadecenoyl-CoA + FAD + H(+) <=> (2E,9Z)-octadecadienoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671737", "l": "p-T774-PKN1 binds CDC25C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614933", "l": "ACEIs bind ACE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990471", "l": "piRNA uni-strand cluster binding", "d": ["Binding to uni-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) that map predominantly to only one strand and exhibit hallmarks of canonical Pol II transcription. Uni-strand piRNA clusters are found in many taxa."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19140", "l": "17beta-estradiol + AH2 + O2 <=> 6beta-hydroxyestradiol-17beta + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21475", "l": "ATP + citrate + CoA <=> (3S)-citryl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22730", "l": "L-selenocysteinyl-tRNA(Sec) + phosphate => H(+) + L-seryl-tRNA(Sec) + selenophosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40228", "l": "3'-phosphoadenylyl sulfate + desulfo-A47934 => A47934 + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0032131", "l": "alkylated DNA binding", "d": ["Binding to an alkylated residue in DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1973968", "l": "Beta-defensins 4A and 103 bind CCR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42765", "l": "formate + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => CO2 + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-593685", "l": "Netrin-4 binds DCC/UNC5A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37120", "l": "7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine => 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15240", "l": "2 Fe(III)-[cytochrome c2] + NADPH <=> 2 Fe(II)-[cytochrome c2] + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376122", "l": "DSCAM/DSCAML1 homodimerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70961", "l": "3-(4-hydroxyphenyl)pyruvate + H2O2 + NH4(+) => D-tyrosine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38791", "l": "1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051996", "l": "squalene synthase activity", "d": ["Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015418", "l": "ABC-type quaternary ammonium compound transporting activity", "d": ["Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H+ + phosphate + quaternary ammonium(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9825782", "l": "p-S207 KARS1 dimer binds MITF-M:HINT1 dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638009", "l": "CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45613", "l": "H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948018", "l": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990312", "l": "type-II cohesin domain binding", "d": ["Binding to a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5634750", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74613", "l": "UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-glucosamine(in) => UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-glucosamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17146", "l": "2'-hydroxy-2,3-dihydrodaidzein + NADP(+) => 2'-hydroxydaidzein + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26068", "l": "3-(hydrohydroxyphosphoryl)pyruvate + acetyl-CoA + H2O = CoA + H(+) + phosphinomethylmalate", "d": [], "t": []}, {"i": "EC:2.3.3.18", "l": "\"2-phosphinomethylmalate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141348", "l": "PAO:FAD oxidises NASPM to PTCN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0016886", "l": "ligase activity, forming phosphoric ester bonds", "d": ["Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}, {"i": "EC:6.5.-.-", "l": "\"Forming phosphoric ester bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102411", "l": "quercetin-3,4'-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) = quercetin 3,4'-O-diglucoside + UDP(3-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68299", "l": "dodecanoyl-CoA + L-seryl-[protein] <=> CoA + O-dodecanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112430", "l": "Formation of P-TEFb complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982778", "l": "Growth hormone binds the growth hormone receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33314", "l": "2 A + hydroxylamine + NH4(+) <=> 2 AH2 + H(+) + H2O + N2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28814", "l": "2,3-dioxo-L-gulonate(in) + Na(+)(in) <=> 2,3-dioxo-L-gulonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24121", "l": "H(+) + leukotriene E4 + NADPH + O2 => 20-hydroxy-leukotriene E4 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59718", "l": "D-maltopentaonate + H(+) => D-maltopentaono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006992", "l": "MECP2 is phosphorylated at S423 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052642", "l": "lysophosphatidic acid phosphatase activity", "d": ["Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35538", "l": "cyclo(L-phenylalanyl-L-leucyl) + O2 <=> cyclo[(Z)-alpha,beta-didehydrophenylalanyl-L-leucyl] + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.18", "l": "\"ATP deaminase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29430", "l": "(R)-carnitine(out) + 4-(trimethylamino)butanoate(in) <=> (R)-carnitine(in) + 4-(trimethylamino)butanoate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.13", "l": "\"ADP-ribose diphosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429441", "l": "SYK activation by SRC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69976", "l": "6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase] => (22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450187", "l": "TAK1 is activated within the TAK1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53592", "l": "1-tetradecanoyl-sn-glycerol 3-phosphate + H2O = 1-tetradecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050237", "l": "pyridoxine 4-oxidase activity", "d": ["Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687094", "l": "p-S MAPK6,4 phosphorylate MAPKAPK5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41095", "l": "H2O + sphing-4-enine-phosphocholine = H(+) + phosphocholine + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64430", "l": "glycyl-L-proline(in) + H(+)(in) => glycyl-L-proline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102633", "l": "flaviolin monooxygenase activity", "d": ["Catalysis of the reaction: flaviolin-2-olate + NADH + H+ + O2 = mompain + NAD + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856794", "l": "Unknown dehydrogenase oxidizes 4-HBz (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047918", "l": "GDP-mannose 3,5-epimerase activity", "d": ["Catalysis of the reaction: GDP-mannose = GDP-L-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034211", "l": "GTP-dependent protein kinase activity", "d": ["GTP dependent catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5681980", "l": "ATG12 binds ATG7 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64897", "l": "2 H2O + UTP => 2 H(+) + 2 phosphate + UMP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n12", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68573", "l": "L-tyrosine(in) => L-tyrosine(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694071", "l": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689544", "l": "UCHL5 binds INO80 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1679098", "l": "Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623632", "l": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28384", "l": "D-glucose 6-phosphate + L-lysine => H2O + N(6)-(6-phospho-D-fructosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39265", "l": "(13Z)-docosenoyl-CoA + NADP(+) => (2E,13Z)-docosadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913374", "l": "Phosphorylated SHC1 recruits SHIP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164832", "l": "ATPase synthesizes ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352232", "l": "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10136", "l": "2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.47", "l": "\"tartronate-semialdehyde synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854182", "l": "TBC1D17 binds OPTN:RAB8A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71118", "l": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44492", "l": "3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692770", "l": "SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39390", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA <=> (2E,17Z,20Z,23Z,26Z)-dotriacontapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69027", "l": "H(+) + N-hydroxy-L-aspartate + NADPH + O2 <=> H2O + N,N-dihydroxy-L-aspartate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56220", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44470", "l": "a 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48974", "l": "ADP + H(+) + phosphate + phosphite(in) => ATP + H2O + phosphite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71843", "l": "tauroursodeoxycholate(out) = tauroursodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-507875", "l": "Aquaporins passively transport urea into cells (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25576", "l": "3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX", "d": [], "t": []}, {"i": "EC:1.3.3.4", "l": "\"protoporphyrinogen oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76108", "l": "(11R)-methyl carlactonoate + 2-oxoglutarate + O2 => (11R)-hydroxymethyl carlactonoate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.798022316275805", "identifiers": [{"i": "GO:0001653", "l": "peptide receptor activity", "d": ["Combining with an extracellular or intracellular peptide to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72722", "l": "eIF2 activation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43894", "l": "[sulfur carrier]-SH + L-alanine => [sulfur carrier]-H + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784323", "l": "IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5679239", "l": "ULK complex translocates to the ER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8949580", "l": "F1Fo ATP synthase dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-507871", "l": "Aquaporins passively transport glycerol out of cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38630", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA <=> 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24538", "l": "N-formyl-L-kynurenine => L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13491", "l": "berberine + 2 H2O2 => (S)-canadine + H(+) + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0061677", "l": "2-dehydro-3-deoxy-D-gluconate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5674385", "l": "p-T,Y MAPKs dimerize (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78729", "l": "3-oxodocosanoyl-CoA + H(+) + NADH => (3S)-hydroxydocosanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22048", "l": "7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.12", "l": "\"6-pyruvoyltetrahydropterin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8862380", "l": "HSD17B13 binds lipid droplets (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38678", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68681", "l": "3'-phosphoadenylyl sulfate + 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(beta-D-glucuronate) => 3alpha,20alpha-dihydroxy-5beta-pregnane 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614414", "l": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3002798", "l": "Cytosolic PLK1 translocates to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189053", "l": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11942", "l": "CO2 + L-ornithine + NH4(+) => 2 H(+) + H2O + L-citrulline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684267", "l": "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0000095", "l": "S-adenosyl-L-methionine transmembrane transporter activity", "d": ["Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism."], "t": []}, {"i": "REACT:R-HSA-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27372", "l": "acetoin + CoA + NAD(+) <=> acetaldehyde + acetyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801184", "l": "TP53 stimulates STEAP3 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.52", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43466", "l": "(2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] => H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30106", "l": "2,5-didehydro-D-gluconate + H(+) + NADH <=> 5-dehydro-D-gluconate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39801", "l": "20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + NADH => 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20462", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine => an N,N,N-trimethylornithine lipid + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249378", "l": "STING recruits TBK1 and STAT6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8979071", "l": "KDM6B binds iron (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51794", "l": "2,3-dihydroxybenzoate + H2O + NAD(+) => H(+) + NADH + O2 + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372542", "l": "Loading of dopamine into synaptic veiscles (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5357477", "l": "PAK1-3 phosphorylates VE-cadherin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27968", "l": "6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate => 7,8-dihydroneopterin 3'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46263", "l": "an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.25", "l": "\"thiomorpholine-carboxylate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "72.891320072305717", "identifiers": [{"i": "GO:0015926", "l": "glucosidase activity", "d": ["Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67831", "l": "a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine <=> a lipid A disaccharide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53439", "l": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51777", "l": "4-prenylphlorisobutanophenone + dimethylallyl diphosphate => deoxycohumulone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877153", "l": "STARD7 binds PC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31945", "l": "(25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51693", "l": "prephenate + S-adenosyl-L-methionine => 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30302", "l": "2-oxoglutarate + a methylated nucleobase within DNA + O2 <=> a nucleobase within DNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9838035", "l": "CLPXP binds mitochondrial matrix proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193647", "l": "IRAK is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004050", "l": "apyrase activity", "d": ["Catalysis of the reaction: a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 phosphate. This reaction consists of two distinct successive phosphate-releasing steps, with NDPs as intermediates. Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112602", "l": "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-430183", "l": "NCK binds PAK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29556", "l": "H2O + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11727", "l": "[thioredoxin]-disulfide + adenosine 3',5'-bisphosphate + 2 H(+) + sulfite <=> 3'-phosphoadenylyl sulfate + [thioredoxin]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73946", "l": "dehydrogriseofulvin + H(+) + NADPH <=> griseofulvin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73545", "l": "dCDP(in) + UTP(out) => dCDP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50184", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66411", "l": "ATP + glutathione(in) + glycochenodeoxycholate(in) + H2O <=> ADP + glutathione(out) + glycochenodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46052", "l": "a 3'-end uridylyl-uridine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-751019", "l": "The Ligand:GPCR:G12/13 complex dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430183", "l": "NCK binds PAK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928604", "l": "SFKs phosphorylate VAV2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.7", "l": "\"interstitial collagenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71495", "l": "Aldolase tetramers convert GA3P and DHAP to F1,6PP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78872", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NAD(+) => a very-long-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236968", "l": "Egress of internalized antigen into cytosol from early endosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264834", "l": "Endocytosis and degradation of apoA-I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62108", "l": "an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798749", "l": "Exocytosis of specific granule lumen proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0033200", "l": "inositol heptakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0010285", "l": "L,L-diaminopimelate aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H2O + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983707", "l": "SYK autophosphorylates at the activated BCR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6803545", "l": "ATP7A transports cytosolic Cu2+ to phagosomal lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9821410", "l": "PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76421", "l": "(8S)-annullatin E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 2-hydroxymethyl-3-pentylphenol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77719", "l": "a neolactoside IV(3)-alpha-NeuGc-nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a neolactoside IV(4)-beta-GalNAc-IV(3)-alpha-NeuGc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40668", "l": "2-aminoprop-2-enoate => 2-iminopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19354", "l": "glycocholate + H2O => cholate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694625", "l": "nsp3 cleaves nsp1-4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6790038", "l": "Expression of HSP90B1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400204", "l": "PPARA binds RXRA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9633044", "l": "ESR binds STRN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72146", "l": "AH2 + GTP + S-adenosyl-L-methionine <=> 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + A + H(+) + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70899", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39073", "l": "(2E)-dodecenedioyl-CoA + H2O2 => dodecanedioyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202222", "l": "Phosphorylation of PKC theta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40211", "l": "(3S)-hydroxytetradecanedioyl-CoA + NAD(+) = 3-oxotetradecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75840", "l": "H(+)(in) + K(+)(in) + Na(+)(out) + serotonin(out) => H(+)(out) + K(+)(out) + Na(+)(in) + serotonin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35582", "l": "1-O-(trans-sinapoyl)-beta-D-glucose + anthocyanin A8 <=> anthocyanin A11 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32641", "l": "(6E)-8-oxolinalool + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (6E)-8-hydroxylinalool + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22995", "l": "3-oxopropanoate + CoA + NAD(+) <=> acetyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200326", "l": "creatine + ATP => phosphocreatine + ADP [CK octamer] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31045", "l": "2 H(+) + methylmalonate + NADH => (S)-2-methyl-3-oxopropanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9824979", "l": "XPO1 binds p-S69,73 MITF-M (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67863", "l": "3'-phosphoadenylyl sulfate + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] <=> 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237119", "l": "Acireductone is oxidized to MOB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9659611", "l": "ANO1 inhibitors bind ANO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-418172", "l": "F2R binds ARRB2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22760", "l": "Cypridina luciferin + O2 = CO2 + hnu + oxidized Cypridina luciferin", "d": [], "t": []}, {"i": "EC:1.13.12.6", "l": "\"Cypridina-luciferin 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37877", "l": "methyl aklanonate + S-adenosyl-L-homocysteine => aklanonate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18979", "l": "a quinol + dihydroxyacetone phosphate => a quinone + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30865", "l": "L-tyrosine + phosphate => 4-O-phospho-L-tyrosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74927", "l": "(3R)-3-[(carboxymethyl)amino]butanoate + H(+) + holo-[ACP] = (2E)-butenoyl-[ACP] + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674546", "l": "CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202168", "l": "Phosphorylation of ZAP-70 by Lck (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-499981", "l": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975814", "l": "Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928597", "l": "EPH:EFN dimers tetramerise (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28459", "l": "biotin(in) => biotin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182986", "l": "CBL-mediated ubiquitination of CIN85 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022378", "l": "ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29459", "l": "beta-alanine(in) + H(+)(in) = beta-alanine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26414", "l": "a secondary aliphatic amine + H2O + O2 = a primary amine + an aldehyde + H2O2", "d": [], "t": []}, {"i": "EC:1.4.3.4", "l": "\"monoamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46349", "l": "(2E)-octenoyl-CoA + H2O => 3-hydroxyoctanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817258", "l": "DUX4, TPRXL, TPRX1, and TPRX2 bind the DUXB gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840429", "l": "DELE1(143-515) binds EIF2AK1 (HRI) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165726", "l": "Phosphorylation of Ribosomal protein S6 by activated S6K1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733403", "l": "PCSK9 binds PCSK9 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672966", "l": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.5", "l": "\"3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.108", "l": "\"2,5-diketocamphane 1,2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17199", "l": "2 4-hydroxyphenylacetate + 2 CO2 => 2 3-(4-hydroxyphenyl)pyruvate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193808", "l": "5beta-cholestan-3alpha,7alpha,27-triol is translocated from the cytosol to the mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.195", "l": "\"N-hydroxythioamide S-beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59057", "l": "2 methanethiol + NAD(+) => dimethyl disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236970", "l": "Proteasomal clevage of exogenous antigen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62328", "l": "(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) = (+)-malbrancheamide + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006588", "l": "MECP2 binds the PTPN4 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975633", "l": "atROL binds to RBP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932599", "l": "CALB1 binds 4xCa2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791235", "l": "GADD45A binds AURKA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1592297", "l": "Full activation of MMP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67430", "l": "2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62843", "l": "GDP-beta-L-fucose + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35230", "l": "H(+)(out) + rifampicin(in) <=> H(+)(in) + rifampicin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-400143", "l": "Fatty acid ligands activate PPARA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618328", "l": "ATAT acetylates microtubules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38546", "l": "H(+) + malonyl-CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein] <=> (2-aminobenzoyl)acetyl-CoA + CO2 + L-cysteinyl-[PqsD protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174097", "l": "Association of Emi1 with Cdh1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982807", "l": "JAK2 phosphorylation of GHR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2682349", "l": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72669", "l": "Met-tRNAi binds to eIF2:GTP to form the ternary complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77613", "l": "Binding of ADAR2 homodimer to dsRNA duplex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42852", "l": "3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.3.1.244", "l": "\"2-methylbutanoate polyketide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0005412", "l": "glucose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61378", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164832", "l": "ATPase synthesizes ATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77342", "l": "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71302", "l": "chloride(out) + L-isoleucine(out) + 2 Na(+)(out) <=> chloride(in) + L-isoleucine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30777", "l": "H2O2 + NH4(+) + pyridoxal => H2O + O2 + pyridoxamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-443774", "l": "Trans-homodimerization of Neurofascin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647680", "l": "CASP1 cleaves GSDMD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250938", "l": "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17892", "l": "H2O + phosphoethanolamine <=> acetaldehyde + NH4(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77658", "l": "2-[(1R,8S,14R,15R)-11-hydroxy-14,15-bis[(6E)-oct-6-en-1-yl]-3,5,9-trioxo-4,10-dioxatetracyclo[9.4.0.0(2,6).0(8,12)]pentadeca-2(6),12-dien-8-yl]acetate + 3 2-oxoglutarate + 3 O2 <=> 3 CO2 + H2O + phomoidride A + 3 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70542", "l": "glutamate + acetyl CoA => N-acetyl glutamate + CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60116", "l": "2-oxoglutarate + methylphosphonate + O2 = CO2 + hydroxymethylphosphonate + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.71", "l": "\"methylphosphonate hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047142", "l": "enzyme-thiol transhydrogenase (glutathione-disulfide) activity", "d": ["Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647680", "l": "CASP1 cleaves GSDMD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847875", "l": "ARF1:GTP binds Golgin TRIP11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67130", "l": "(1R,8aS)-octahydroindolizin-1-ol + CO2 + CoA + 2 H2O + 3 NADP(+) => 5 H(+) + L-pipecolate + malonyl-CoA + 3 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51194", "l": "2-oxoglutarate + H(+) + NADPH => (R)-2-hydroxyglutarate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69005", "l": "Cdc6 protein is phosphorylated by CDK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50948", "l": "a 2'-deoxycytidine in single-stranded DNA + H(+) + H2O = a 2'-deoxyuridine in single-stranded DNA + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.38", "l": "\"single-stranded DNA cytosine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029151", "l": "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61242", "l": "3-phenylpyruvate + H2O2 + NH4(+) => H2O + L-phenylalanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44773", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 => 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36321", "l": "CoA + 2 NADP(+) + octadecan-1-ol => 2 H(+) + 2 NADPH + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50387", "l": "H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline <=> 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73598", "l": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-750988", "l": "Inactive G alpha (z) reassociates with G beta:gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29733", "l": "beta-maltose(out) => beta-maltose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610732", "l": "GSK3 phosphorylates p-GLI3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79026", "l": "beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->6)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196417", "l": "Reduction of desmosterol to cholesterol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65489", "l": "3 ATP => 2',3',3'-c-tri-AMP + 3 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66001", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10680", "l": "L-proline = D-proline", "d": [], "t": []}, {"i": "EC:5.1.1.4", "l": "\"proline racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862700", "l": "CMKLR1 binds Resolvin E1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043729", "l": "2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity", "d": ["Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6789136", "l": "Myeloperoxidase (MPO) binds to the bacterial cell surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.827361769567034", "identifiers": [{"i": "GO:0005248", "l": "voltage-gated sodium channel activity", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}, {"i": "REACT:R-HSA-5576895", "l": "SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62469", "l": "3,4-dihydroxybenzoate + ATP + H(+) => 3,4-dihydroxybenzoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74717", "l": "3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine => 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016212", "l": "kynurenine-oxoglutarate transaminase activity", "d": ["Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50685", "l": "H2O + N(5)-phenyl-L-glutamine => aniline + H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433418", "l": "Phosphorylation of JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727767", "l": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001065", "l": "mitochondrial single subunit type RNA polymerase activity", "d": ["Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624893", "l": "RAN stimulates fusion of nuclear envelope (NE) membranes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-532549", "l": "MPI isomerises Fru6P to Man6P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66501", "l": "GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32889", "l": "2 all-trans-retinal => all-trans-beta-carotene + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617087", "l": "CEBPA binds the promoter of the GFI1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199959", "l": "ERKs are inactivated by protein phosphatase 2A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53253", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] => 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686930", "l": "RIPK3 is cleaved by CASP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37362", "l": "D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] <=> D-glucosamine 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49709", "l": "nocardicin G + S-adenosyl-L-methionine => H(+) + isonocardicin C + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9706315", "l": "Active FLT3 binds to SH2B3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45404", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate = 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2424482", "l": "p85 regulatory unit of PI3K binds p-6Y-SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56014", "l": "beta-D-mannose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729307", "l": "Nucleoprotein is SUMOylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964333", "l": "G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11842", "l": "benzoate + 2 H(+) + NADH => benzaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0050694", "l": "galactose 3-O-sulfotransferase activity", "d": ["Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35850", "l": "ATP + sphing-4-enine <=> ADP + H(+) + sphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59223", "l": "(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O <=> (2Z)-2-hydroxypenta-2,4-dienoate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14883", "l": "asparagusate + H(+) + NADH => 3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26411", "l": "H2O + N-acetyl-D-muramate 6-phosphate => (R)-lactate + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75507", "l": "n H(+)(out) + taurocholate(out) = n H(+)(in) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9853512", "l": "DLST transfers succinyl to CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30608", "l": "A + all-trans-phytofluene => AH2 + all-trans-zeta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607750", "l": "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803978", "l": "S-nitrosylation of cysteine residues in proteins by N2O3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66316", "l": "an inositol phosphomannosyl-alpha-1->6-inositol-1-phospho-N-acyl-4R-hydroxysphinganine + H2O = alpha-D-mannosyl-di-(inositol-1-phosphate) + an N-acyl-(4R)-4-hydroxysphinganine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16572", "l": "2-oxoglutarate + L-lysyl-[collagen] + O2 <=> (5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62287", "l": "2 ATP + L-proline + L-tryptophan + NADPH <=> (S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + 2 AMP + 2 diphosphate + H(+) + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3247840", "l": "WLS binds WNT ligands in the Golgi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395784", "l": "Nascent CMs transform into mature CMs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14519", "l": "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA => (E)-feruloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48774", "l": "3-deacetyl-3-vinylbacteriochlorophyllide a + H2O => 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9612501", "l": "SGK phosphorylates CREB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.187", "l": "\"GDP-4-dehydro-D-rhamnose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54869", "l": "(2E)-butenoyl-[ACP] + H(+) + NADH => butanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170977", "l": "FRS2 is phosphorylated by active TrkA receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825275", "l": "Expression of DLL1 in presomitic mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15942", "l": "H2O + N(2)-acetyl-L-ornithine => acetate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39077", "l": "(3S)-hydroxydodecanedioyl-CoA => (2E)-dodecenedioyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27681", "l": "ATP + dCDP <=> ADP + dCTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174157", "l": "Degradation of multiubiquitinated Cyclin B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4341048", "l": "SUMOylation of RXRA with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026967", "l": "VKORC1 inhibitors binds VKORC1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693584", "l": "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690785", "l": "BAP1 binds Ub-HCFC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156910", "l": "Formation of eEF1B complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13413", "l": "ADP + thymidine = AMP + dTMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.118", "l": "\"ADP--thymidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30912", "l": "a sphingomyelin + H2O => a carboxylate + sphing-4-enine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938108", "l": "SERPINB13 binds cathepsin L (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614605", "l": "Persulfide sulfur is dioxygenated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42469", "l": "2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O => 2-oxopent-4-enoate + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015132", "l": "prostaglandin transmembrane transporter activity", "d": ["Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56168", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050417", "l": "glutamin-(asparagin-)ase activity", "d": ["Catalysis of the reaction: H2O + L-glutamine = NH3 + L-glutamate; and H2O + L-asparagine = NH3 + L-aspartate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799350", "l": "Exocytosis of specific granule membrane proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201595", "l": "Caspase-mediated cleavage of plakophilin-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52898", "l": "2 ADP + 2 H(+) + 2 L-glutamate + Ni-sirohydrochlorin a,c-diamide + 2 phosphate => 2 ATP + 2 H2O + 2 L-glutamine + Ni-sirohydrochlorin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42417", "l": "a ubiquinone + L-proline => (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10650", "l": "6-hydroxyhexan-6-olide + H2O + NADP(+) => 2-hydroxycyclohexan-1-one + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21561", "l": "3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol => 1,4-dithiothreitol + 2,3-epoxyphylloquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928597", "l": "EPH:EFN dimers tetramerise (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43734", "l": "a 1,3-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77890", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)glycine + O2 <=> (1-deoxy-D-fructos-1-yl)amine + glyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2534388", "l": "Progesterone Activation Of CatSper (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73797", "l": "FAICAR => IMP + H2O (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027042", "l": "CPY4 ω-oxidises 14(S)-HDHA to MaR-L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73003", "l": "anthranilate + 2 ATP + L-tryptophan = (R)-benzodiazepinedione + 2 AMP + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69628", "l": "N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72199", "l": "Ca(2+)(in) + 2 H(+)(out) = Ca(2+)(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75797", "l": "Na(+)(in) + nicotinate(in) => Na(+)(out) + nicotinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8964284", "l": "BTK in active Gq-BTK complex is activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62467", "l": "1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O <=> 2-nonadioyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.200", "l": "\"tetracenomycin A2 monooxygenase-diooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52382", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+) => a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018746", "l": "RHOQ binds effectors at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45465", "l": "eicosanoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => (5Z)-eicosenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034526", "l": "2-methylnaphthalene hydroxylase activity", "d": ["Catalysis of the reaction: 2-methylnaphthalene + NADH + O2 + H+ = 2-hydroxymethylnaphthalene + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933533", "l": "Dimerization of p-IRF7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35985", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450463", "l": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27743", "l": "2'-deoxyadenosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698962", "l": "Binding of pPR-AP to pAP to form the pPR-AP:pAP Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877902", "l": "Activated AR binds RUNX2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56799", "l": "ATP + cob(I)alamin-[corrinoid adenosyltransferase] <=> adenosylcob(III)alamin + apo-[corrinoid adenosyltransferase] + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39206", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADPH <=> NADP(+) + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59258", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) => Fe(III)-enterobactin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29284", "l": "L-alanine(in) + Na(+)(in) => L-alanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30323", "l": "all-trans-beta-carotene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = beta-cryptoxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17491", "l": "cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) => H(+) + NADH + O2 + phthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54278", "l": "(3S)-3-hydroxy-L-aspartyl-[protein] + CO2 + succinate => 2-oxoglutarate + L-aspartyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983424", "l": "Budding of COPII coated vesicle (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39807", "l": "octadecanoate(in) = octadecanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6791109", "l": "GADD45A binds PCNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-399947", "l": "Tyrosine phosphorylation of CRMPs by Fes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0033757", "l": "glucoside 3-dehydrogenase activity", "d": ["Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202137", "l": "AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18635", "l": "2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate => 2 ATP + H2O + hydrogencarbonate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853322", "l": "Plasma membrane FGFR1 fusions dimerize (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62004", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc6S derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75446", "l": "heme b(in) <=> heme b(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56835", "l": "2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+) <=> 2,3,6-trichlorohydroquinone + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27839", "l": "9H-carbazole + H(+) + NADH + O2 => 2'-aminobiphenyl-2,3-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53281", "l": "D-threose => D-erythrulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14763", "l": "3-oxosphinganine + CO2 + CoA => H(+) + hexadecanoyl-CoA + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25165", "l": "A + butanoyl-CoA => (2E)-butenoyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14113", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O = a 3'-end 2'-deoxyribonucleotide-DNA + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.32", "l": "\"polynucleotide 3'-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814091", "l": "ARL1 recruits TGN Golgin homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33062", "l": "(R)-dihydrolipoamide + NAD(+) <=> (R)-lipoamide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75856", "l": "Abortive Initiation Before Second Transition (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940554", "l": "MMP2 cleaves OPTC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032442", "l": "phenylcoumaran benzylic ether reductase activity", "d": ["Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24004", "l": "butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801101", "l": "RABGGTA binds RABGGTB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16357", "l": "A + succinate = AH2 + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011981", "l": "EP300 is recruited to MYC and BCL2 genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005128", "l": "erythropoietin receptor binding", "d": ["Binding to an erythropoietin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13612", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72114", "l": "L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) <=> L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944650", "l": "miR-214 microRNA binds PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69408", "l": "11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) = androst-4-ene-3,11,17-trione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-199456", "l": "PTEN dephosphorylates PIP3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52387", "l": "L-glutamate + O-phospho-L-serine <=> H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.148", "l": "\"acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44659", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a monoacyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093339", "l": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008682", "l": "3-demethoxyubiquinol 3-hydroxylase activity", "d": ["Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416929", "l": "PTGFR binds PGF2a (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18752", "l": "[protein]-dithiol + NAD(+) <=> [protein]-disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647977", "l": "ICMT methylates S-Farn RAS proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022378", "l": "ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71665", "l": "a menaquinol + fumarate + 2 H(+)(in) => a menaquinone + 2 H(+)(out) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026771", "l": "DPEP hydrolyses MCTR2 to MCTR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683467", "l": "CQ, HCQ are protonated to CQ2+, HCQ2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174425", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.312", "l": "\"D-glutamate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952626", "l": "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-389889", "l": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870469", "l": "RGGT geranylgeranylates RAB proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78212", "l": "D-leucine + H2O + O2 => 4-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67730", "l": "diphosphate + DNA(n)-Z => DNA(n) + dZTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69299", "l": "CDT1 binds geminin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677051", "l": "Formation of the PCAF-ATAC complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63867", "l": "O2 + octadecanoate <=> (2R)-2-hydroperoxyoctadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021954", "l": "MECP2 binds OPRK1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17596", "l": "3-phenylpyruvate + L-glutamine <=> 2-oxoglutaramate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19756", "l": "ATP + diphthine-[translation elongation factor 2] + NH4(+) <=> AMP + diphosphate + diphthamide-[translation elongation factor 2] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74181", "l": "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981931", "l": "RAC1 and CDC42 activate PAK2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917744", "l": "GABA loaded synaptic vesicle Docking and Priming (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41206", "l": "1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64221", "l": "H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2162192", "l": "COQ2 ligates all-E-10PrP2 to PHB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1497784", "l": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102561", "l": "D-ribose 2,5-bisphosphate 2-phosphohydrolase activity", "d": ["Catalysis of the reaction: H2O + D-ribofuranose 2,5-bisphosphate = hydrogenphosphate + D-ribofuranose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62775", "l": "N-acetyl-D-phenylalanine <=> N-acetyl-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197958", "l": "FPGS-2 transforms THF to THFPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12022", "l": "a monocarboxylate + NH4(+) => a monocarboxylic acid amide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434989", "l": "SEMA7A binds to PLXNC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932980", "l": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3785711", "l": "Telomere shortening during replicative exhaustion (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114352", "l": "Sequestration of tBID by BCL-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10636", "l": "D-mannonate + NADP(+) = D-mannuronate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10607", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70510", "l": "LDH tetramer oxidises LACT to PYR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35847", "l": "ATP + sphing-4-enine = ADP + H(+) + sphing-4-enine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34232", "l": "5-nitrosalicylate + O2 => 4-nitro-6-oxohepta-2,4-dienedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264679", "l": "Serum albumin binds 2-lysophosphatidylcholine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50198", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193766", "l": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37201", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67413", "l": "alpha-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79073", "l": "(4Z,15Z)-bilirubin IXalpha C8,C12-beta-D-bisglucuronoside + UDP => (4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250217", "l": "ARL2:GTP binds ARL2BP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696274", "l": "RND1 binds GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31557", "l": "(3S)-3-aminobutanoyl-CoA + acetoacetate => (5S)-5-amino-3-oxohexanoate + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836435", "l": "p-PKR dimer phosphorylates SNCA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47718", "l": "21-hydroxyprogesterone + H(+) + NADH => 4-pregnen-20,21-diol-3-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47158", "l": "7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH => 7alpha,25-dihydroxycholesterol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429591", "l": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58225", "l": "L-glutamyl-[protein] + NAD(+) => 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12123", "l": "alpha-D-glucose 1-phosphate + ATP + H(+) <=> ADP-alpha-D-glucose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10748", "l": "H(+) + hydrogencarbonate = CO2 + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.1", "l": "\"carbonic anhydrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654734", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76997", "l": "NADPH + 2 oxidized [4Fe-4S]-[ferredoxin] => H(+) + NADP(+) + 2 reduced [4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61587", "l": "cytidine(72) in tRNA(Cys) + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA(Cys) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201630", "l": "Caspase-mediated cleavage of Acinus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48371", "l": "beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer + GDP-beta-L-fucose <=> beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39315", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA = (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69205", "l": "ATP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + L-glutamate => ADP + H(+) + L-glutamyl-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57883", "l": "3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose <=> 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022876", "l": "protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23693", "l": "(R)-malate => H2O + maleate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27844", "l": "2'-aminobiphenyl-2,3-diol + NADP(+) => 9H-carbazole + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52398", "l": "CO2 + dihydroxyacetone phosphate + NADH => 4-O-phospho-D-threonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25199", "l": "5-amino-6-(D-ribitylamino)uracil + phosphate => 5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648017", "l": "EML4 binds to microtubules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51645", "l": "cholesterol + H(+) + NADH + O2 => 7-dehydrocholesterol + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5164399", "l": "BCO2:Fe2+ cleaves betaC to APO10al and bION (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73812", "l": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48306", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+) => a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8948136", "l": "ULK1 Translocates to the mitochondria (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204392", "l": "Basigin binds MCT1, MCT3 and MCT4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68533", "l": "(2E,6E)-farnesyl diphosphate => (Z)-alpha-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839095", "l": "p-BCR-pFGFR1 binds GRB2:GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35164", "l": "H(+)(out) + minocycline(in) => H(+)(in) + minocycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37230", "l": "(E,E)-sorbate + H(+) <=> (E)-1,3-pentadiene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37888", "l": "S-adenosyl-L-methionine + small RNA 3'-end nucleotide => H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65192", "l": "2 2-oxoglutarate + 2 O2 + preaustinoid A = berkeleytrione + 2 CO2 + H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49471", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose <=> a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322057", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67447", "l": "an (R)-2-hydroxy-long-chain-fatty acyl-CoA <=> a long-chain fatty aldehyde + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102784", "l": "lutein oxygenase activity", "d": ["Catalysis of the reaction: lutein + 2 O2 = 3-hydroxy-beta-ionone + 3-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60901", "l": "a cytidine in RNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in RNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35894", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.78", "l": "\"GDP-D-glucose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5690213", "l": "DNA polymerases delta, epsilon or kappa bind the GG-NER site (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24477", "l": "H2O + maleimide => H(+) + maleamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53072", "l": "2-methoxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57142", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76500", "l": "TBXAS1 isomerises PGH2 to TXA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49253", "l": "D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] => D-fructose 1-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22376", "l": "uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA", "d": [], "t": []}, {"i": "EC:5.4.99.12", "l": "\"tRNA pseudouridine(38-40) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12060", "l": "acetyl-CoA + 5 H(+) + 6 malonyl-CoA = 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21869", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O => 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67743", "l": "N-acetyl-beta-neuraminate <=> aceneuramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947499", "l": "Exchange of oxygen with sulfur in MoCo (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382056", "l": "Crk binds to the active PDGF receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0102973", "l": "norsolorinate anthrone synthase activity", "d": ["Catalysis of the reaction: 7 malonyl-CoA + 5 H+ + a hexanoyl-[acyl-carrier-protein] = norsolorinate anthrone + 7 coenzyme A + 7 carbon dioxide + 2 H2O + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38866", "l": "phosphate + sucrose 6(F)-phosphate <=> alpha-D-glucose 1-phosphate + beta-D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59438", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AMP + diphosphate => 4-amino-L-phenylalanine + ATP + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31723", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3S)-2,4',7-trihydroxyisoflavanone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68286", "l": "CoA + O-hexanoyl-L-seryl-[protein] => hexanoyl-CoA + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106099", "l": "2-keto-3-deoxy-L-rhamnonate aldolase activity", "d": ["Catalysis of the reaction 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58408", "l": "NADP(+) + undecan-1-ol = H(+) + NADPH + undecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47817", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-diphosphate + NADPH + O2 => 9-ribosyl-trans-zeatin 5'-diphosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9677320", "l": "PTGS1 dimer binds PTGS1 Inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851129", "l": "NTPDase3 hydrolyzes nucleoside diphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45187", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + NH4(+) <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983161", "l": "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944349", "l": "TLE tetramers bind TCF/LEF at WNT promoters (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55894", "l": "a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+) => a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730752", "l": "NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-179417", "l": "Multiubiquitination of Nek2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24395", "l": "dTDP-L-dihydrostreptose + streptidine 6-phosphate <=> dTDP + H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047202", "l": "sinapoylglucose-choline O-sinapoyltransferase activity", "d": ["Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + choline = O-sinapoylcholine + D-glucose."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74372", "l": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139895", "l": "tBID activates BAK protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51440", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 = (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694462", "l": "ABHD6,12 hydrolyse 3AG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33490", "l": "(4R)-hydroxysphinganine + 2-hydroxyhexacosanoyl-CoA <=> CoA + H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61526", "l": "(15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17113", "l": "H2O + L-serine-phosphoethanolamine = H(+) + L-serine + phosphoethanolamine", "d": [], "t": []}, {"i": "EC:3.1.4.13", "l": "\"serine-ethanolaminephosphate phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37172", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247849", "l": "WLS dissociates from retromer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64295", "l": "3,8,9,10-tetrahydroxy-6-methyl-1,4-dihydroanthracen-1-one + H(+) + NADPH <=> (3R)-3,8,9,10-tetrahydroxy-6-methyl-1,2,3,4-tetrahydroanthracen-1-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789208", "l": "HOCl-induced glycosaminoglycan fragmentation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36908", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA => (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5250217", "l": "ARL2:GTP binds ARL2BP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909729", "l": "Activation of JAK kinases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5674018", "l": "BRAP binds RAS:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76495", "l": "acetyl-CoA + D-glutamate = CoA + H(+) + N-acetyl-D-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9627106", "l": "SMAC (DIABLO) forms dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10508", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37365", "l": "5 A + beta-staphylobilin + Fe(2+) + formaldehyde + 4 H2O => 5 AH2 + 2 H(+) + heme b + 4 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210805", "l": "Removal of miRNA passenger strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603784", "l": "PEX19:class I PMP binds PEX3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19940", "l": "glycine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63624", "l": "hexadecanoyl-AMP + holo-[ACP] = AMP + H(+) + hexadecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.4.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19493", "l": "D-cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.20", "l": "\"cellobiose phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64506", "l": "2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine => AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-984733", "l": "Kinesin-3 is a dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73065", "l": "H(+)(in) + Mn(2+)(out) => H(+)(out) + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46399", "l": "an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (11E)-Delta(11)-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4085087", "l": "Canstatin binds integrins alphaVbeta3, alphaVbeta5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40246", "l": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) <=> 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41037", "l": "1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA => 1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52888", "l": "N-phenylhydroxylamine + NADP(+) = H(+) + NADPH + nitrosobenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158137", "l": "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654714", "l": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69152", "l": "spermine monoaldehyde = acrolein + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9824994", "l": "RPS6KA1-dependent phosphorylation of MITF-M (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38604", "l": "NADP(+) => 2'-phospho-cyclic ADP-ribose + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71243", "l": "chloride(out) + hypotaurine(out) + 2 Na(+)(out) = chloride(in) + hypotaurine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66612", "l": "N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA = methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697077", "l": "Rv1410c transports lprG:LM,LAM from cytosol to the cell wall (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44102", "l": "2 H(+) + NADH + octanoate => H2O + NAD(+) + octanal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72805", "l": "L-arginine(in) + N(omega)-methyl-L-arginine(out) => L-arginine(out) + N(omega)-methyl-L-arginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.176", "l": "\"propanoyl-CoA C-acyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.99.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49874", "l": "(+)-dehydrodiconiferyl acid carboxylate + a quinol + H(+) => (+)-dehydrodiconiferyl acid ketone + a quinone + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693593", "l": "D-loop extension by DNA polymerases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54101", "l": "N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14243", "l": "3-acetylamino-4-hydroxybenzaldehyde + CoA + H(+) => 3-amino-4-hydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21818", "l": "a 2-oxocarboxylate + H2O2 + NH4(+) => a D-alpha-amino acid + H2O + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654730", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25098", "l": "ATP + UDP = ADP + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34198", "l": "2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 <=> 2 aureusidin 6-O-beta-glucoside + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914182", "l": "14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40426", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44556", "l": "4-hydroxybenzoate + all-trans-hexaprenyl diphosphate = 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36046", "l": "all-trans-8'-apo-beta-carotenal + O2 <=> 13-apo-beta-carotenone + 2,6-dimethyldeca-2,4,6,8-tetraenedial", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55334", "l": "a 3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => a 3'-hydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52411", "l": "4-phospho-D-erythronate + NAD(+) <=> CO2 + dihydroxyacetone phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18700", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) <=> (4-hydroxyphenyl)acetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43592", "l": "all-trans-zeaxanthin + O2 = (3R)-3-hydroxy-8'-apo-beta-carotenal + 3beta-hydroxy-beta-cyclocitral", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004372", "l": "glycine hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74019", "l": "glycine(out) + L-alanine(in) = glycine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1471322", "l": "Beta-defensins are secreted (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050070", "l": "lysolecithin acylmutase activity", "d": ["Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine = 2-acyl-sn-glycero-3-phosphocholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389354", "l": "Activation of Vav1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.616479785166973", "identifiers": [{"i": "GO:0016623", "l": "oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen."], "t": []}, {"i": "EC:1.2.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618328", "l": "ATAT acetylates microtubules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693356", "l": "CEMIP hydrolyses HA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.140", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33887", "l": "(-)-secoisolariciresinol + 2 NAD(+) = (-)-matairesinol + 2 H(+) + 2 NADH", "d": [], "t": []}, {"i": "EC:1.1.1.331", "l": "\"secoisolariciresinol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64268", "l": "emodin anthrone + O2 = emodin + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9866253", "l": "apo-UQCRFS1 binds LYRM7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793485", "l": "PRKN polyubiquitinates RIPK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9011595", "l": "GSTZ1 dimer dehalogenates DCA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-379387", "l": "COMT transfers Met to DA to form 3MT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31333", "l": "adenylyl-molybdopterin + diphosphate => ATP + H(+) + molybdopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15963", "l": "H(+) + taxiphyllin + UDP => 4-hydroxymandelonitrile + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948621", "l": "miR-20 microRNAs bind VAPA mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40690", "l": "1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol <=> 1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961846", "l": "CCNE1 gene transcription is stimulated by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800798", "l": "The PIDDosome binds CASP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44335", "l": "ATP + L-alanine + L-anticapsin <=> ADP + bacilysin + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654159", "l": "Activated FGFR2 binds PLCG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013435", "l": "RHOD auto-activates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13196", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) <=> 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8936608", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9628756", "l": "NEIL1 G83D does not cleave FapyA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77128", "l": "1D-myo-inositol 1,2,3-trisphosphate + H2O => 1D-myo-inositol 2,3-bisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665998", "l": "MKL1 binds SRF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18779", "l": "an alkane + Hg(2+) => an alkylmercury + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36906", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine <=> 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604703", "l": "RUNX1 binds NOTCH4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77754", "l": "(2E,10E)-dode-2,10-dicenoyl-CoA + H2O + oxaloacetate <=> (4E,11E)-2-hydroxytrideca-4,11-dien-1,2,3-tricarboxylate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29291", "l": "(25S)-3-oxocholest-4-en-26-oate + ATP + CoA = (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.42", "l": "\"3-oxocholest-4-en-26-oate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033265", "l": "choline binding", "d": ["Binding to choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24908", "l": "(E)-4-coumarate + NH4(+) => L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36663", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA = (2S,5S)-5-carboxymethylproline + CO2 + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.226", "l": "\"carboxymethylproline synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876789", "l": "CARNMT1 methylates CARN to Anserine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17392", "l": "D-arabinitol + NAD(+) <=> D-ribulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9615348", "l": "AGT(34-41) binds to AGTR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9660557", "l": "RAS:GTP binds RAL GDS proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51334", "l": "11-hydroperoxy-(8Z,12E,14Z)-eicosatrienoate => (8Z,11Z,14Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23984", "l": "cholesterol + NADP(+) = 7-dehydrocholesterol + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.21", "l": "\"7-dehydrocholesterol reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9836606", "l": "SPHK1 binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730876", "l": "Phosphorylation of IKK-beta by TAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49909", "l": "(R)-carnitine(out) + O-acetyl-(R)-carnitine(in) => (R)-carnitine(in) + O-acetyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35935", "l": "2 ATP + L-proline + L-tryptophan = 2 AMP + brevianamide F + 2 diphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54108", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + guaia-4,6-diene", "d": [], "t": []}, {"i": "EC:4.2.3.179", "l": "\"guaia-4,6-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22876", "l": "(R)-mandelamide + H2O = (R)-mandelate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.86", "l": "\"mandelamide amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682388", "l": "Autophagosome maturation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035966", "l": "Defective GGT1 does not hydrolyse GSH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32265", "l": "L-alanine + succinate semialdehyde => 4-aminobutanoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008545", "l": "JUN kinase kinase activity", "d": ["Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase."], "t": []}, {"i": "REACT:R-HSA-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36137", "l": "(E)-hexadec-2-enoate + 2 H(+) + NADH => (2E)-hexadecenal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106100", "l": "beta-pinacene synthase activity", "d": ["Catalysis of the cyclization of geranylgeranyl pyrophosphate (GGPP) to yield the monocyclic diterpene beta-pinacene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-482788", "l": "p-S54,92,203-BRF1 binds 14-3-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52243", "l": "2 H2O + 2 Mn(2+) + O2 <=> 4 H(+) + 2 MnO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74315", "l": "O-isobutanoyl-(R)-carnitine(in) = O-isobutanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625510", "l": "FOXO1 and p-2S-SMAD2/3:SMAD4 bind MSTN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201425", "l": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66420", "l": "ATP + glutathione(in) + H2O + tauroursodeoxycholate(in) = ADP + glutathione(out) + H(+) + phosphate + tauroursodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14650", "l": "demethyllactenocin + dTDP-beta-L-mycarose => demethylmacrocin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964619", "l": "PAK1 binds ARHGEF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694656", "l": "Spike trimer glycoside chains are extended (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47019", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O <=> [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629946", "l": "JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76394", "l": "glycylglycylglycine(out) + n H(+)(out) <=> glycylglycylglycine(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851038", "l": "BTN3A1 binds prenylated phosphoantigens (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047295", "l": "geranylgeranylglycerol-phosphate geranylgeranyltransferase activity", "d": ["Catalysis of the reaction: (2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390120", "l": "Phosphorylated HPO dimer phosphorylates TH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836606", "l": "SPHK1 binds PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35318", "l": "H(+) + hexadecanoyl-CoA + malonyl-CoA <=> 3-oxooctadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0035662", "l": "Toll-like receptor 4 binding", "d": ["Binding to a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68960", "l": "DNA polymerase epsilon binds at the origin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174446", "l": "Removal of remaining Flap from the C-strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70625", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66066", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminohexanoate => 2-oxohexanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23953", "l": "H2O + N-(2-phenylethyl)acetamide => 2-phenylethylamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "54.297657734501001", "identifiers": [{"i": "GO:0005267", "l": "potassium channel activity", "d": ["Enables the energy-independent facilitated diffusion of a potassium ion through a transmembrane aqueous pore or channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42396", "l": "cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.205", "l": "\"tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9680443", "l": "ROCK1,2 bind ROCKi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975919", "l": "Addition of galactose by beta 4-galactosyltransferases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45579", "l": "(2R)-ethylmalonyl-CoA <=> (2S)-methylsuccinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021950", "l": "MECP2 binds MEF2C gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14909", "l": "L-gulonate + NADP(+) = aldehydo-D-glucuronate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.19", "l": "\"glucuronate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35268", "l": "ethanol(in) => ethanol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35593", "l": "H(+) + hydrogen sulfide + (n-1) sulfur => H2 + n sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64178", "l": "(9Z)-octadecenoate + L-tryptophan => H2O + N-(9Z-octadecenoyl)-L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72055", "l": "glycodeoxycholate(out) + 2 Na(+)(out) = glycodeoxycholate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5629218", "l": "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790038", "l": "Expression of HSP90B1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48358", "l": "GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide => GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020513", "l": "GRIN2B gene expression is inhibited by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56389", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 => (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67901", "l": "glutarate + succinyl-CoA => glutaryl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18156", "l": "2 GTP + H(+) <=> diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9650473", "l": "SERPING1 is secreted (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63746", "l": "UDP + zolarsartan-1-N-beta-D-glucuronide => UDP-alpha-D-glucuronate + zolasartan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20539", "l": "(R)-4'-phosphopantetheine + apo-[ACP] + H(+) => H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49047", "l": "H(+) + NADH + O2 + protoasukamycin <=> 4-hydroxyprotoasukamycin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12006", "l": "H(+) + indican + UDP => indoxyl + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-606349", "l": "Mis18 complex binds the centromere (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176452", "l": "Degradation of ubiquitinated SMAD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51301", "l": "(9Z)-octadecenoate + L-phenylalanine => H2O + N-(9Z-octadecenoyl)-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1369017", "l": "Activation of ATP sensitive Potassium channels in muscle cells (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44032", "l": "9,10-epoxy-(12Z)-octadecenoate + H2O = 9,10-dihydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987214", "l": "p-STAT3 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204873", "l": "Interaction of Tie2 and Shp2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8944242", "l": "Association of procollagen type XXVII (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482696", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34108", "l": "glycine + H(+) + hexadecanoyl-CoA => 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41494", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45661", "l": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52448", "l": "16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77017", "l": "1-hydroxy-4-methylpentan-2-one + H(+) + NADH + NH4(+) => (S)-leucinol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44397", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1-heptadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57719", "l": "hydrogencarbonate + NH4(+) <=> carbamate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53870", "l": "1-hydroxyphenazine + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + phenazine-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9646468", "l": "mTORC1 binds RHEB:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24424", "l": "2 glutathione + L-dehydroascorbate = glutathione disulfide + L-ascorbate", "d": [], "t": []}, {"i": "EC:1.8.5.1", "l": "\"glutathione dehydrogenase (ascorbate)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748951", "l": "HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193711", "l": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17609", "l": "L-seryl-[sulfatase] + S-adenosyl-L-methionine = 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:1.1.98.7", "l": "\"serine-type anaerobic sulfatase-maturating enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047751", "l": "3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: 3-oxo-5alpha-steroid + NADP+ = a 3-oxo-delta(4)-steroid + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9649733", "l": "mature p21 RAS binds GDP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197958", "l": "FPGS-2 transforms THF to THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52477", "l": "estrone + UDP-alpha-D-glucuronate => estrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26060", "l": "Co(I)-[methylamine-specific corrinoid protein] + H(+) + methylamine => methyl-Co(III)-[methylamine-specific corrinoid protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023346", "l": "MECP2 binds NOTCH1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36393", "l": "desmosterol + H(+) + NADPH => cholesterol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8983872", "l": "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66838", "l": "asperterpenoid A + 5 H(+) + 5 H2O + 4 oxidized [NADPH--hemoprotein reductase] => 4 O2 + preasperterpenoid A + 4 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034932", "l": "1-methoxypyrene 6,7-monooxygenase activity", "d": ["Catalysis of the reaction: 1-methoxypyrene + O2 + 2 H+ + 2 e- = 1-methoxypyrene-6,7-oxide + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162227", "l": "GUSB tetramer hydrolyses (HA)2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050091", "l": "melilotate 3-monooxygenase activity", "d": ["Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + H+ + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21992", "l": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1980125", "l": "ITCH binds DTX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60754", "l": "CoA + jasmolin I => (1R,3R)-chrysanthemoyl-CoA + (Z,S)-jasmololone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75812", "l": "acetoacetate(out) + Na(+)(out) => acetoacetate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050369", "l": "[tyrosine 3-monooxygenase] kinase activity", "d": ["Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72976", "l": "2 ATP + 2 indole-3-pyruvate => 2 AMP + didemethylasterriquinone D + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032770", "l": "Translocation of YAP1 to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418170", "l": "F2R:ARRB1 binds MAPKs, SRC-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40243", "l": "(3R)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50080", "l": "ATP + H2O + taurodeoxycholate(in) = ADP + H(+) + phosphate + taurodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0098634", "l": "cell-matrix adhesion mediator activity", "d": ["The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the extracellular matrix."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78221", "l": "5-guanidino-2-oxopentanoate + H2O2 + NH4(+) => D-arginine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165195", "l": "GTP loading by Rheb (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63991", "l": "2-thiocytidine + ATP <=> 2-thiocytidine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41837", "l": "H(+) + hexanoyl-[ACP] + malonyl-[ACP] => 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73802", "l": "dimethylallyl diphosphate + isoechinulin A <=> dehydroechinulin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8982017", "l": "Active G alpha (q) binds RGS proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29826", "l": "chloride(in) <=> chloride(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51596", "l": "2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin] = 4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8984001", "l": "IL35 binds IL27RA:IL12RB2 receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54281", "l": "2-oxoglutarate + L-aspartyl-[ankyrin-repeat domain protein] + O2 => (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62394", "l": "3-dehydrolevoglucosan + H(+) + NADH => levoglucosan + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32193", "l": "2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34650", "l": "S-adenosyl-L-methionine + squalene <=> 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13126", "l": "CoA + glutathione disulfide => CoA-glutathione + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50587", "l": "13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) <=> 15-oxoprostaglandin E1 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987007", "l": "p-STAT1 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218815", "l": "p-6Y-VEGFR2 binds NCK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8877620", "l": "ECE2 cleaves EDN1(53-90) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8940561", "l": "MMP7 cleaves OPTC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-200512", "l": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-452838", "l": "Expression of NANOG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40438", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25510", "l": "(1S,5S)-sabinene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39005", "l": "a 1-acyl-sn-glycero-3-phosphate + ethanolamine + H(+) => a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25336", "l": "H(+) + L-cysteine + tRNA(Cys) => H2O + L-cysteinyl-tRNA(Cys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54201", "l": "N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74015", "l": "4-hydroxybenzoate + H(+) + phosphate = CO2 + H2O + phenyl phosphate", "d": [], "t": []}, {"i": "EC:4.1.1.123", "l": "\"phenyl-phosphate phosphatase/carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050133", "l": "N6-hydroxylysine O-acetyltransferase activity", "d": ["Catalysis of the reaction: N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983153", "l": "E1 mediated ubiquitin activation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75550", "l": "2 (3R)-3-isocyanylbutanoyl-[ACP] + ATP + L-lysine + 2 NADPH <=> (2S)-2,6-bis[(3R)-3-isocyanobutanamido]hexan-1-ol + AMP + diphosphate + 2 holo-[ACP] + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196753", "l": "2xPPCS ligates PPanK with Cys (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156526", "l": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40062", "l": "decanoyl-CoA + H2O <=> CoA + decanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2162253", "l": "PDSS1,2 ligates FPP to IPPP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839384", "l": "Inhibin-A binding to TGFBR3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612493", "l": "EGR-dependent NAB2 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41518", "l": "H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase] => O2 + phylloquinone + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200474", "l": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810357", "l": "Fillagrin and keratin intermediate filaments polymerize forming a network (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668605", "l": "RAC2:GTP binds NOX2 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23471", "l": "2-aminobenzenesulfonate + 2 H(+) + NADH + O2 <=> 2,3-dihydroxybenzenesulfonate + NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17730", "l": "an acyl-CoA + cholesterol => a cholesterol ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031073", "l": "cholesterol 26-hydroxylase activity", "d": ["Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73863", "l": "dopamine(out) = dopamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61266", "l": "H2O2 + NH4(+) + pyruvate => H2O + L-alanine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222116", "l": "L3MBTL1 binds TP53 monomethylated on K382 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809764", "l": "SBF1 binds MTMR2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21276", "l": "D-arabinitol + NADP(+) = D-xylulose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46541", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39886", "l": "dTDP-6-deoxy-alpha-D-allose + NADP(+) <=> dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53005", "l": "2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate => 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099520", "l": "monoatomic ion antiporter activity involved in regulation of presynaptic membrane potential", "d": ["Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19772", "l": "phaseollidin hydrate <=> H2O + phaseollidin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047224", "l": "acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 3-O-N-acetyl-D-galactosalaminyl-[protein] + UDP-N-acetyl-D-glucosamine = 3-O-N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-[protein] + UDP. Linkage of the glycan to the protein occurs via the oxygen atom in the side chain of an L-serine or L-threonine residue."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726580", "l": "PGR binds PGR agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20756", "l": "(E)-caffeoyl-CoA + D-threo-isocitrate = 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.126", "l": "\"isocitrate O-dihydroxycinnamoyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211924", "l": "CYP4B1 12-hydroxylates ARA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806957", "l": "MET receptor dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391377", "l": "Luteinizing hormone receptor can bind LH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44646", "l": "a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+) => a 2'-deoxyribonucleoside 5'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58402", "l": "H(+) + heptanal + NADPH => heptan-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53411", "l": "(1S,4R)-1-hydroxylimonen-2-one + H(+) + NADPH + O2 <=> (4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429415", "l": "SYK binds to integrin alphaIIb beta3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9835411", "l": "FA core complex:HSP70s binds PKR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114671", "l": "vWF binds to collagen (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199093", "l": "CXADR binds to AMICA1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9865579", "l": "MT-CO1 and MT-CO2 complexes associate, installing heme moieties (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55274", "l": "11-cis-retinyl tetradecanoate + CoA => 11-cis-retinol + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855219", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67948", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58494", "l": "ADP + Fe(III)-enterobactin(in) + H(+) + phosphate => ATP + Fe(III)-enterobactin(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69763", "l": "a medium-chain fatty aldehyde + H2O + NAD(+) = a medium chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9825759", "l": "MAPK-dependent phosphorylation of KARS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158781", "l": "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44838", "l": "a globoside NOR2 (d18:1(4E)) + H(+) + UDP => a globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39626", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62703", "l": "H2O + naphtopyrone YWA1 <=> acetoacetate + H(+) + naphthalene-1,3,6,8-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390929", "l": "HTR1 and 5A receptors can bind serotonin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0015165", "l": "pyrimidine nucleotide-sugar transmembrane transporter activity", "d": ["Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211962", "l": "CYP4F11 16-hydroxylates 3OH-PALM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76846", "l": "H2O + NAD(+) + octylamine <=> H(+) + NADH + NH4(+) + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.12", "l": "\"cGMP-dependent protein kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69719", "l": "(indol-3-yl)acetate + ATP + H(+) = (indol-3-yl)acetyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77282", "l": "2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA <=> 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4655355", "l": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782141", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29972", "l": "2'-deoxyinosine(in) + H(+)(in) => 2'-deoxyinosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71287", "l": "chloride(out) + L-arginine(out) + 2 Na(+)(out) = chloride(in) + L-arginine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9015379", "l": "Factor IIa inhibitors (compounds) binds IIa (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.24", "l": "\"gelatinase A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20921", "l": "2,4-dichlorophenol + H(+) + NADPH + O2 => 3,5-dichlorocatechol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29123", "l": "nitrate(out) + ubiquinol-8(in) = H2O(out) + nitrite(out) + ubiquinone-8(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25772", "l": "2-oxoglutarate + L-asparagine + O2 = (2S,3S)-3-hydroxyasparagine + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.39", "l": "\"L-asparagine oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212432", "l": "Formation of DRIP coactivator complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188345", "l": "The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37479", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72445", "l": "(E)-feruloyl-CoA + AMP + H(+) => (E)-feruloyl-AMP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59410", "l": "acetate + L-aspartate => H2O + N-acetyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75879", "l": "Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) + L-proline betaine = methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + N-methyl-L-proline", "d": [], "t": []}, {"i": "EC:2.1.1.388", "l": "\"proline betaine--corrinoid protein Co-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46265", "l": "an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004757", "l": "sepiapterin reductase (NADP+) activity", "d": ["Catalysis of the reactions: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H+ + 2 NADPH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102291", "l": "11alpha-hydroxy-beta-amyrin dehydrogenase activity", "d": ["Catalysis of the reaction: 11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11-oxo-beta-amyrin + 2 H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9008043", "l": "MAPK8 phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17027", "l": "H(+) + L-xylulose + NADPH => NADP(+) + xylitol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18436", "l": "cyclohexylamine + H2O + O2 <=> cyclohexanone + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2106625", "l": "Duplex siRNA is loaded into Argonaute (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60352", "l": "2-heptyl-3-hydroxy-4(1H)-quinolone + O2 = CO + H(+) + N-octanoylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21508", "l": "all-trans-retinyl hexadecanoate + H2O = H(+) + hexadecanoate + retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855375", "l": "PTPN22 dissociates from CSK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58457", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate + H2O => (R)-glycerate + D-mannose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29522", "l": "alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46071", "l": "(3E)-nonenoyl-CoA <=> (2E)-nonenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69510", "l": "H(+) + N-acetyl-D-glucosaminate => H2O + N-acetyl-D-glucosamino-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692764", "l": "MAPK6 binds CCND3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79089", "l": "an N-choloyl-L-alpha-amino acid + H2O => an L-alpha-amino acid + cholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66440", "l": "butan-2-one + NADP(+) = but-3-en-2-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10973", "l": "a D-hexose + H(+) + phosphoramidate => alpha-D-hexose 1-phosphate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12122", "l": "ADP-alpha-D-glucose + diphosphate => alpha-D-glucose 1-phosphate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18325", "l": "(2E,6E)-farnesyl diphosphate = (+)-amorpha-4,11-diene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.24", "l": "\"amorpha-4,11-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9686969", "l": "APC/C:Cdh1 polyubiquitinates SKP2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690023", "l": "NUBPL binds 4Fe-4S (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53239", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63321", "l": "a glycerophospholipid(in) + ATP + H2O => a glycerophospholipid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12145", "l": "cyanidin 3-O-rutinoside + UDP-alpha-D-glucose => cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12334", "l": "ADP + Fe(3+)(in) + H(+) + phosphate => ATP + Fe(3+)(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70486", "l": "PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69508", "l": "H2O + N-acetyl-D-glucosamino-1,5-lactone = H(+) + N-acetyl-D-glucosaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047112", "l": "pyruvate oxidase activity", "d": ["Catalysis of the reaction: H+ + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858346", "l": "AMHR2 binds AMH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67525", "l": "4,8-dimethylnonanoyl-CoA + H2O => adenosine 3',5'-bisphosphate + 2 H(+) + S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32246", "l": "alpha-D-ribose 1,5-bisphosphate <=> D-ribulose 1,5-bisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675376", "l": "Cytosolic DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102494", "l": "GA20 2,3-desaturase activity", "d": ["Catalysis of the reaction: gibberellin A20 + O2 + a reduced electron acceptor = gibberellin A5 + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3076905", "l": "Extracellular BTD hydrolyses BCTN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35588", "l": "FMN + H2O => phosphate + riboflavin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22624", "l": "(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.39", "l": "\"4-hydroxy-2-oxovalerate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373745", "l": "SDK1 homophillic interaction (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196840", "l": "3xPPCDC:3FMN decarboxylates PPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350168", "l": "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852010", "l": "BTNL2 binds activated T cells surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35509", "l": "glycyrrhetaldehyde + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 30-hydroxy-11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11910", "l": "butanoate + H(+) + pentan-2-one => H2O + nonane-4,6-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649711", "l": "NEIL1,NEIL2 incises DNA strand 5' to the AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672969", "l": "Phosphorylation of RAF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56642", "l": "(9Z,12Z)-octadecadienoate + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2464803", "l": "RDH8 reduces atRAL to atROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295622", "l": "SPRY2 binds CBL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046871", "l": "N-acetylgalactosamine binding", "d": ["Binding to N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938356", "l": "RMB14 binds RUNX2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3134914", "l": "Beta-catenin migrates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59467", "l": "NADP(+) + octadecan-1-ol <=> H(+) + NADPH + octadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5358912", "l": "MSH2:MSH6 exchanges ADP for ATP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769014", "l": "NPAS4 stimulates GEM gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12278", "l": "3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] => 3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38402", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O <=> (9Z)-hexadecenoate + 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12669", "l": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.43", "l": "\"[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014454", "l": "RHOG translocates to the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9691215", "l": "VEGFA-165 dimer binds VEGFR2 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395328", "l": "LTBP1, LTBP3 bind TGF-Beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76351", "l": "oxaloacetate(in) + sulfate(out) = oxaloacetate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3134946", "l": "DDX41 ubiquitination by TRIM21 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39929", "l": "1-O-alkyl-sn-glycero-3-phosphate + choline + H(+) => 1-O-alkyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6810474", "l": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53464", "l": "1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68564", "l": "6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37818", "l": "(R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2 <=> 2-methyl-4-chlorophenol + CO2 + pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33842", "l": "(2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin + H(+) <=> 7-O-geranyl-2-O,3-dimethylflaviolin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-349444", "l": "Phosphorylation of COP1 at Ser-387  by ATM (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34564", "l": "CDP-alpha-D-abequose + NADP(+) => CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909721", "l": "Translocation of ISGF3 complex to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13540", "l": "(2R)-3-phosphoglycerate + GDP-alpha-D-mannose <=> 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24374", "l": "H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine => H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800794", "l": "PIDD1 associates with CRADD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32694", "l": "(2E)-geranyl diphosphate <=> (E)-beta-ocimene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38644", "l": "1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68900", "l": "4-methoxybenzoate + ATP + H(+) + NADPH = 4-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.571199156962493", "identifiers": [{"i": "GO:0005402", "l": "carbohydrate:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42188", "l": "3beta-hydroxy-5alpha-androstan-17-one + NAD(+) = 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0052671", "l": "geranylgeraniol kinase activity", "d": ["Catalysis of the reaction: geranylgeraniol + nucleoside triphosphate = all-trans-geranyl-geranyl monophosphate + nucleoside diphosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850777", "l": "SPINK6 binds KLK14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14323", "l": "H(+) + morphinone + NADPH => morphine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928607", "l": "p-EPHs bind VAV2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202947", "l": "Caspase mediated cleavage of APC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043907", "l": "Cys-tRNA(Pro) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Cys-tRNA(Pro)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755777", "l": "SARS-CoV-2 M, N bind to PDPK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19768", "l": "glycerol <=> 3-hydroxypropanal + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769345", "l": "Activated glucocorticoid receptor represses NPAS4 gene transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16643", "l": "a long-chain fatty acid + ethanol + H(+) => a long-chain fatty acyl ethyl ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39733", "l": "3,16-dihydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 3-hydroxyhexadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6790038", "l": "Expression of HSP90B1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701507", "l": "PTPN6 dephosphorylates JAK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66971", "l": "alpha-D-mannosyl-(1->3)-alpha-D-galactosyl-diphospho-di-trans,octa-cis-undecaprenol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40972", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3149432", "l": "Transport of VPU to Plasma Membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22976", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084912", "l": "Arresten binds integrin alpha1beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5661290", "l": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70832", "l": "L-arginine(in) + L-leucine(out) + Na(+)(out) => L-arginine(out) + L-leucine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388605", "l": "POMC(138-176) binds MC2R (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22711", "l": "H2O + S-acylglutathione <=> a carboxylate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102412", "l": "valerena-4,7(11)-diene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) = valerena-4,7(11)-diene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130349", "l": "Generation of CLIP from lip10 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70097", "l": "peniphenone D => (R)-5-methyl-tetronate + o-quinone methide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77587", "l": "Docking of Mature Replication Dependent Histone mRNA with the NPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033443", "l": "AAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AAA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981657", "l": "IL34 dimer binds PTPRZ1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57093", "l": "AH2 + S-(methylsulfanyl)glutathione => A + glutathione + methanethiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35543", "l": "3-phosphooxypyruvate + H2O = 3-hydroxypyruvate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008345", "l": "RUNX2-P1 binds RUNX2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9825747", "l": "CREBBP acetylates HINT1 dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388605", "l": "POMC(138-176) binds MC2R (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163764", "l": "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160133", "l": "bicarbonate channel activity", "d": ["Enables the energy-independent facilitated diffusion of bicarbonate through a transmembrane aqueous pore or channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193737", "l": "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2031355", "l": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47905", "l": "ATP + N-(acetyl)-sphing-4-enine => ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51003", "l": "[fructose-bisphosphate aldolase]-L-lysine + 3 S-adenosyl-L-methionine <=> [fructose-bisphosphate aldolase]-N(6),N(6),N(6)-trimethyl-L-lysine + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64459", "l": "L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-990489", "l": "Kinesin-13 is a dimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34501", "l": "H2O + oxidized 2[4Fe-4S]-[ferredoxin] + pentalenate => 1-deoxypentalenate + 2 H(+) + O2 + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3247847", "l": "WLS is endocytosed to the early endosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5679205", "l": "ULK1 phosphorylates Beclin-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28549", "l": "alpha-D-glucose <=> alpha-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508247", "l": "Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63077", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA => 2-acetylphloroglucinol + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199062", "l": "KLRC1:KLRD1 heterodimer interacts with HLA-E (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44724", "l": "2,3-saturated fatty aldehyde + NADP(+) = (2E)-fatty aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762246", "l": "ANGPTL4 binds CDH11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49150", "l": "dTDP-alpha-D-forosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine => dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444171", "l": "Receptor FFAR2 binds carboxylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69047", "l": "2-nitrobutanedioate <=> fumarate + H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-166214", "l": "FA anion flip-flops to the opposite surface (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74282", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a lipid IVA <=> a 2-acyl-sn-glycero-3-phosphocholine + a lipid IVB", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71364", "l": "17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) => 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805740", "l": "SETD8 methylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36912", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26551", "l": "(S)-piperazine-2-carboxamide + H2O => (S)-piperazine-2-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035639", "l": "purine ribonucleoside triphosphate binding", "d": ["Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62484", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042610", "l": "CD8 receptor binding", "d": ["Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9605600", "l": "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-392053", "l": "SOS binds Grb2 bound to pFAK:NCAM1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.25", "l": "\"L-arginine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015183", "l": "L-aspartate transmembrane transporter activity", "d": ["Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626228", "l": "The distal appendage proteins recruit TTBK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877691", "l": "MAP2K6 phosphorylates PIP4K2B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76709", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32518", "l": "(4S,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O <=> (3S,6R)-6-hydroxy-3-isopropenylheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47708", "l": "ADP + alpha-D-glucose 1-phosphate + H(+) = ADP-alpha-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51918", "l": "2-oxobutanoate + NH4(+) => (2S)-2-amino-3-butenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:1990472", "l": "piRNA dual-strand cluster binding", "d": ["Binding to dual-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) where piRNAs originate from both DNA strands via noncanonical transcription."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33204", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66824", "l": "2 ATP + 2 cob(II)inamide + 2 H2O + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)inamide + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45253", "l": "tetradecanoate(out) => tetradecanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5226999", "l": "ADD1:ADD3 binds DMTN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28142", "l": "H2O + streptothricin D = streptothricin D acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24712", "l": "L-glutamate + UDP-beta-L-threo-pentopyranos-4-ulose => 2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30374", "l": "(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O <=> (-)-geosmin + acetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114671", "l": "vWF binds to collagen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19896", "l": "4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP <=> 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938853", "l": "CDK6 binds RUNX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.8", "l": "\"3'-phosphate/5'-hydroxy nucleic acid ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61900", "l": "AH2 + betaenone C = A + betaenone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15814", "l": "1H-imidazole + acetyl-CoA => CoA + N-acetylimidazole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-168136", "l": "Activated JNKs phosphorylate c-JUN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033819", "l": "lipoyl(octanoyl) transferase activity", "d": ["Catalysis of the reaction: L-lysyl-[protein] + octanoyl-[ACP] = H+ + holo-[ACP] + N6-octanoyl-L-lysyl-[protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66221", "l": "asc-omegaC7-CoA + O2 => asc-omegaDeltaC7-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56243", "l": "1,2-dioctanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] <=> 2-octanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl octanoate + apo--[retinol-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036201", "l": "ent-isokaurene C2-hydroxylase activity", "d": ["Catalysis of the reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2alpha-hydroxyisokaurene + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13588", "l": "ATP + butanoate <=> ADP + butanoyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202604", "l": "Formation of a heteromeric BMP receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64673", "l": "2-(methylsulfanyl)acetyl-CoA + butan-1-ol => butyl 2-(methylsulfanyl)acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62293", "l": "(S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + A + H(+) => 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140630", "l": "all-trans-phytoene synthase activity", "d": ["Catalysis of the reaction: 2 geranylgeranyl diphosphate -> all-trans-phytoene + 2 diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34622", "l": "1-deoxypentalenate + 2-oxoglutarate + O2 <=> 1-deoxy-11beta-hydroxypentalenate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35415", "l": "an anthocyanidin 3-O-beta-D-sambubioside + UDP-alpha-D-glucose = an anthocyanidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.295", "l": "\"anthocyanin 3-O-sambubioside 5-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25806", "l": "3-aminopropanal + H2O2 + spermidine => H2O + O2 + spermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78898", "l": "a very long-chain fatty acyl-CoA + acetyl-CoA <=> a very-long-chain 3-oxoacyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18644", "l": "a menaquinone + H2 <=> a menaquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20995", "l": "16-hydroxytabersonine + S-adenosyl-L-methionine <=> 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805061", "l": "CK2 binds FACT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804425", "l": "TP53 binds POU4F2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4420140", "l": "SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9864415", "l": "AAC1 imports a proton (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19860", "l": "a 16alpha-hydroxysteroid + NADP(+) <=> a 16-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047241", "l": "lipopolysaccharide N-acetylmannosaminouronosyltransferase activity", "d": ["Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24354", "l": "ethyl 3-oxohexanoate + H(+) + NADPH => ethyl (R)-3-hydroxyhexanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16516", "l": "(S)-lactate + O2 <=> acetate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30809", "l": "Delta(1)-piperideine-2-carboxylate + H(+) + NADH => L-pipecolate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700120", "l": "PTN and MDK bind to PTPRZ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16592", "l": "A + sucrose <=> 3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042767", "l": "ecdysteroid 22-hydroxylase activity", "d": ["Catalysis of the hydroxylation of an ecdysteroid at carbon position 22."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36960", "l": "D-ribono-1,4-lactone + H(+) + NADH => D-ribose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693243", "l": "RHOD translocates to the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4641229", "l": "TLE oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19884", "l": "GTP + L-lysyl-[protein] <=> diphosphate + H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50070", "l": "ADP + glycoursodeoxycholate(out) + H(+) + phosphate => ATP + glycoursodeoxycholate(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-982810", "l": "JAK2 phosphorylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0046557", "l": "glucan endo-1,6-beta-glucosidase activity", "d": ["Catalysis of the random hydrolysis of (1->6) linkages in (1->6)-beta-D-glucans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23127", "l": "2 (2R)-3-phosphoglycerate + 2 H(+) <=> CO2 + D-ribulose 1,5-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165026", "l": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78354", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23684", "l": "(S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase] = allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-937032", "l": "NEMO subunit of IKK complex binds to activated IRAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53058", "l": "H(+) + isowyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine => 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-416358", "l": "G alpha (q) inhibits PI3K alpha (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2299620", "l": "Collagen XI cross-links with collagen II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39351", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA = (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673760", "l": "Ligand-independent dimerization of membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45633", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624948", "l": "KIF17 enters the cilium (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654631", "l": "Activated FGFR3 phosphorylates PPTN11 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70777", "l": "6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite => 6-sulfo-D-quinovose + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40106", "l": "H2O + propanoyl-CoA <=> CoA + H(+) + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327695", "l": "Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28314", "l": "baicalein + UDP-alpha-D-glucuronate = baicalin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112265", "l": "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21703", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O <=> 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74675", "l": "AH2 + archaeol + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + A + 2 H(+) + 2 L-methionine + macrocyclic archaeol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67163", "l": "chloride + FADH2 + melleolide F + O2 <=> 6'-chloromelleolide F + FAD + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388830", "l": "PI3K binds ICOS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70510", "l": "LDH tetramer oxidises LACT to PYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25358", "l": "2-hydroxyphytanoyl-CoA <=> 2,6,10,14-tetramethylpentadecanal + formyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42239", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA <=> 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25109", "l": "ATP + pyridoxine => ADP + H(+) + pyridoxine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19293", "l": "a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3-phosphate", "d": [], "t": []}, {"i": "EC:2.7.1.94", "l": "\"acylglycerol kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20405", "l": "H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate = (2S,6S)-2,6-diaminoheptanedioate + acetate", "d": [], "t": []}, {"i": "EC:3.5.1.47", "l": "\"N-acetyldiaminopimelate deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047559", "l": "3-dehydro-L-gulonate 2-dehydrogenase activity", "d": ["Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654582", "l": "Activated FGFR1 phosphorylates SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2168038", "l": "Collagen type XV restin release (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64613", "l": "ATP + L-glutamate + tRNA(Gln) => AMP + diphosphate + L-glutamyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9839405", "l": "InhibinA-TGFBR3 binding to ACVR2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39202", "l": "(3R)-hydroxytetracosanoyl-CoA <=> (2E)-tetracosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693724", "l": "ESD dimer hydrolyses S-FGSH to GSH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954117", "l": "E2F6:TFDP1 binds EPC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11425", "l": "ATP + L-threonyl-[myosin heavy-chain] => ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40110", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA <=> 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71319", "l": "chloride(out) + L-cysteine(out) + 2 Na(+)(out) = chloride(in) + L-cysteine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59450", "l": "dodecanal + H(+) + NADPH => dodecan-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24613", "l": "17beta-estradiol + NAD(+) => estrone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449087", "l": "CD4 binds Interleukin-16 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40901", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13852", "l": "D-arabinose <=> D-ribulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032548", "l": "pyrimidine deoxyribonucleoside binding", "d": ["Binding to a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000704", "l": "pyrimidine dimer DNA N-glycosylase activity", "d": ["Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034796", "l": "Activated NTRK3 binds PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43108", "l": "2 Fe(III)-[cytochrome c] + H2O + N2 = 2 Fe(II)-[cytochrome c] + 2 H(+) + nitrous oxide", "d": [], "t": []}, {"i": "EC:1.7.2.4", "l": "\"nitrous-oxide reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76320", "l": "L-aspartate(in) + L-leucine(out) => L-aspartate(out) + L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50462", "l": "a medium-chain fatty acyl-[ACP] + AMP + diphosphate => a medium chain fatty acid + ATP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54232", "l": "1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73747", "l": "(R)-noradrenaline(in) + 2 H(+)(out) = (R)-noradrenaline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654587", "l": "Activated FGFR1:p-FRS phosphorylates PPTN11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67530", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + S-(6Z-octenoyl)-4'-phosphopantetheine => (6Z)-octenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616241", "l": "CEBPA binds the promoter of the CEBPE gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74180", "l": "HMG CoA => acetoacetic acid + acetyl CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34350", "l": "(2E)-geraniol + NAD(+) <=> (2E)-geranial + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14653", "l": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.17", "l": "\"3',5'-cyclic-nucleotide phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785213", "l": "LIPC dimer binds heparin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15724", "l": "glycine + H2O + NAD(+) <=> glyoxylate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70975", "l": "CS acetylates OA to citrate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956608", "l": "MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162225", "l": "HEXA cleaves the terminal GalNAc from small HA fragments (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24146", "l": "3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O => 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42853", "l": "3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine => (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-482772", "l": "Release of platelet cytosolic components (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684865", "l": "SFTPB dimer,C translocate from multivesicle body to lamellar body (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34918", "l": "D-galactose(in) <=> D-galactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18046", "l": "6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O => alpha-D-glucose 1-phosphate + alpha-D-mannose derivative + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41521", "l": "menaquinone-4 + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30694", "l": "H2O2 + methanol <=> formaldehyde + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428015", "l": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944229", "l": "Association of procollagen type IX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46155", "l": "15-cis-phytoene + a plastoquinone <=> 15,9'-di-cis-phytofluene + a plastoquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73541", "l": "dCTP(in) + UTP(out) => dCTP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617881", "l": "HOXB4 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20241", "l": "nicotinate + S-adenosyl-L-methionine = N-methylnicotinate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.7", "l": "\"nicotinate N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004795", "l": "threonine synthase activity", "d": ["Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388824", "l": "PTPRF, PTPRS, PTPRD bind Liprins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35281", "l": "3-oxooctadecanoyl-CoA + CoA => acetyl-CoA + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41407", "l": "(R)-2-methylpyrrolidine + NADP(+) <=> 2-methyl-1-pyrroline + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836585", "l": "SUPV3L1:PNPT1 hydrolyzes mitochondrial RNA to yield 4-5 nucleotide oligoribonucleotides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12640", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose <=> (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877192", "l": "RUNX1 binds FOXP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34378", "l": "4-guanidinobutanamide + H2O <=> 4-guanidinobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927889", "l": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201628", "l": "Caspase-mediated cleavage of vimentin at DSVD (85) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981574", "l": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72411", "l": "inulobiose = alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.178", "l": "\"difructose-dianhydride-III synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72185", "l": "creatinine(out) + H(+)(in) => creatinine(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.18", "l": "\"dolichyl-diphosphooligosaccharide--protein glycotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030747", "l": "indolepyruvate C-methyltransferase activity", "d": ["Catalysis of the reaction: indole-3-pyruvate + S-adenosyl-L-methionine = (R)-3-(indol-3-yl)-2-oxobutanoate + H+ + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54260", "l": "2-oxoglutarate + L-asparaginyl-[protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714480", "l": "RAC2 translocates to the mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9667569", "l": "AVPR1A,2 bind AVPR antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211950", "l": "CYP24A1 24-hydroxylates CTL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59356", "l": "H2O + lactobiono-1,5-lactone = H(+) + lactobionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956676", "l": "YAP1 binds TP73 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434004", "l": "viral dsRNA binds the toll-like receptor 3 (TLR3) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17935", "l": "a 7-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine => a 7-hydroxyisoflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0052861", "l": "glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group", "d": ["Catalysis of the endohydrolysis of (1->3)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8867344", "l": "OMA1 hydrolyses OPA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0005345", "l": "purine nucleobase transmembrane transporter activity", "d": ["Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159574", "l": "GLYAT-like proteins transfer glycine to ST-CoA to form SUA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0030145", "l": "manganese ion binding", "d": ["Binding to a manganese ion (Mn)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-877198", "l": "P2X7 mediates membrane pores that include pannexin-1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9709098", "l": "DHFR dimer reduces FOLA to DHF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194518", "l": "RhoA is activated by nucleotide exchange and inhibits axonal growth (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74043", "l": "L-alanine(in) + L-methionine(out) = L-alanine(out) + L-methionine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46713", "l": "pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428888", "l": "Phosphorylation of ROBO1 by ABL kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654167", "l": "Activated FGFR1 binds PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27898", "l": "3'-AMP + H2O = adenosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71332", "l": "chloride(out) + L-phenylalanine(out) + 2 Na(+)(out) => chloride(in) + L-phenylalanine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13007", "l": "H(+) + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-homocysteine => (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008412", "l": "CDK4 phosphorylates RUNX2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49601", "l": "ATP + CoA + octanedioate => AMP + diphosphate + octanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0042910", "l": "xenobiotic transmembrane transporter activity", "d": ["Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77966", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (5R,12R,14S)-dolasta-1(15),8-diene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46087", "l": "H2O + sn-glycerol 1-phosphate <=> glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676204", "l": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69307", "l": "(Z)-glucotropeolin + H2O <=> (Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047701", "l": "beta-L-arabinosidase activity", "d": ["Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43069", "l": "beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + oleanolate + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45473", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32794", "l": "L-ectoine(in) <=> L-ectoine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008732", "l": "L-allo-threonine aldolase activity", "d": ["Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12578", "l": "(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP => (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5622134", "l": "CRABP1 binds atRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24206", "l": "phosphate + sulfoacetaldehyde => acetyl phosphate + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66697", "l": "(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66509", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-sn-glycero-3-phosphocholine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015561", "l": "rhamnose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in)."], "t": []}, {"i": "TCDB:2.A.7.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8938108", "l": "SERPINB13 binds cathepsin L (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77283", "l": "2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57532", "l": "a 5'-end ribonucleotide-RNA + ATP + H(+) = a 5'-end adenosine-5'-diphospho-5'-ribonucleotide-RNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-445714", "l": "Aquaporin-3 passively transports water out of cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.59", "l": "\"mitochondrial intermediate peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71031", "l": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9653514", "l": "USP17L2 deubiquitinates RCE1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428918", "l": "Dissociation of the TP:G13 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62538", "l": "dihydrodigoxigenin + 2 Fe(III)-[cytochrome c] => digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32187", "l": "cholest-5-en-3-one = cholest-4-en-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8986972", "l": "IL24 binds IL20RA:JAK1:IL20RB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78642", "l": "acetyl-CoA + tetracosanoyl-CoA <=> 3-oxohexacosanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6784735", "l": "PCSK9:LDLR bind to Clathrin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41741", "l": "adenosine(57)/adenosine(58) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(1)-methyladenosine(57)/N(1)-methyladenosine(58) in tRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674531", "l": "AAMP binds EGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39868", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol => 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47519", "l": "3-oxochenodeoxycholate + H(+) + NADH <=> isochenodeoxycholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37759", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12560", "l": "hydroquinone + UDP-alpha-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.218", "l": "\"hydroquinone glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50185", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74070", "l": "ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A <=> ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1363276", "l": "Dephosphorylation of p130 (RBL2) by PP2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015184", "l": "L-cystine transmembrane transporter activity", "d": ["Enables the transfer of L-cystine from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-5340130", "l": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390595", "l": "Calcium Binds Troponin-C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45670", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227804", "l": "Inhibition of MDA5-IPS1 signaling by Atg5-Atg12 conjugate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140842", "l": "n fibrin monomers -> fibrin multimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56590", "l": "an aldehyde + hydrogen cyanide => a monosubstituted aliphatic (S)-hydroxynitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865256", "l": "CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14520", "l": "(E)-feruloyl-CoA + H2O <=> 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75181", "l": "(R)-axinyssene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781818", "l": "RNA Pol II initiates transcription from damaged DNA template (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682084", "l": "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73992", "l": "geranylgeranyl diphosphate => beta-araneosene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58500", "l": "glycine betaine + H(+) + NADH + O2 = glyoxylate + H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67914", "l": "1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid => [protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30108", "l": "D-serine + NADP(+) => 2-aminomalonate semialdehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19880", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149518", "l": "MTRR reduces cob(II)alamin to meCbl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66714", "l": "4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + stellatate => 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + stellata-2,6,19-triene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56400", "l": "[(3R)-hydroxybutanoate](n) + H2O = (3R)-hydroxybutanoate tetramer + [(3R)-hydroxybutanoate](n-4) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3781941", "l": "WNTs are secreted in exosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396379", "l": "NOTCH1 Coactivator Complex binds HES5 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012196", "l": "KPNA2 translation is negatively regulated by miR-26A and B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59555", "l": "N,N',N'',N'''-tetraacetylchitotetraose + O2 <=> H2O2 + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913451", "l": "IL3RB is phosphorylated on Ser-585 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392513", "l": "Rap1 signal termination by Rap1GAPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070402", "l": "NADPH binding", "d": ["Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55091", "l": "eburicol + S-adenosyl-L-methionine <=> (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106063", "l": "G protein-coupled folate receptor activity", "d": ["Combining with folate and transmitting the signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-374896", "l": "Uptake of Noradrenaline (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76489", "l": "2 Fe(III)-[cytochrome b5] + 2 H2O + N-acyl-1-deoxysphing-14Z-enine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-acyl-1-deoxysphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0033678", "l": "5'-3' DNA/RNA helicase activity", "d": ["Unwinding of a DNA/RNA duplex in the 5' to 3' direction, driven by ATP hydrolysis."], "t": []}, {"i": "REACT:R-HSA-163120", "l": "Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264689", "l": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199093", "l": "CXADR binds to AMICA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72021", "l": "2 CO2 + H2O + succinate + trihazone D => 2-oxoglutarate + H(+) + O2 + trihazone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-561072", "l": "OCT3 mediates renal uptake of organic cations (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31672", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine => dTDP-alpha-D-mycaminose + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68306", "l": "3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36054", "l": "beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O <=> 2 beta-L-arabinofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010472", "l": "GDP-galactose:glucose-1-phosphate guanylyltransferase activity", "d": ["Catalysis of the reaction: GDP-beta-L-galactose + alpha-D-glucose 1-phosphate = beta-L-galactose-1-phosphate + GDP-alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33966", "l": "ATP + isopentenyl phosphate <=> ADP + isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-982810", "l": "JAK2 phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-113430", "l": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76567", "l": "3'-dehydrocarminate + H(+) = 1,5-anhydro-D-erythro-hex-1-en-3-ulose + kermesate", "d": [], "t": []}, {"i": "EC:4.1.99.28", "l": "\"3'-dehydrocarminate deglycosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.173", "l": "\"L-rhamnose 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102600", "l": "cytochrome P450 dependent 12,13beta-epoxy-beta-amyrin hydroxylase activity", "d": ["Catalysis of the reaction: 12,13beta-epoxy-beta-amyrin + O2 + H+ + NAD(P)H = 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27428", "l": "(2E,6E)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5433074", "l": "ACY1:Zn2+ dimer hydrolyses mercapturic acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090415", "l": "7-hydroxymethyl chlorophyll a reductase activity", "d": ["Catalysis of the reaction: 7-hydroxymethyl chlorophyll a + 2 reduced ferredoxin + 2 H+ chlorophyll a + 2 oxidized ferredoxin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10622", "l": "(E)-cinnamoyl-CoA + H(+) + NADPH => (E)-cinnamaldehyde + CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865182", "l": "OTUD7A hydrolyses K11diUb (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13848", "l": "dihydroxyfumarate + H(+) <=> 2-hydroxy-3-oxopropanoate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17907", "l": "3-hydroxypyruvate + H(+) + NADH => (R)-glycerate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72367", "l": "estrone 3-sulfate(out) + succinate(in) = estrone 3-sulfate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672961", "l": "PP2A dephosphorylates inactive RAFs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1671687", "l": "PRLR activation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25861", "l": "GTP + H2O => 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10630", "l": "a ribonucleoside 5'-diphosphate + tRNA(n) => phosphate + tRNA(n+1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168933", "l": "Dimerization of phosphorylated IRF3/IRF7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39784", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12672", "l": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] <=> L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67350", "l": "apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA => apigenin 7-O-beta-D-glucoside + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30481", "l": "2 H(+) + H2O + N-hydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase] => L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938073", "l": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852132", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38577", "l": "(9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17444", "l": "2-oxoglutarate + L-cysteine <=> 2-oxo-3-sulfanylpropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649856", "l": "Oxidative damage to the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5682983", "l": "ATM phosphorylates WHSC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50355", "l": "3 (R)-methylmalonyl-CoA + 9 H(+) + long-chain fatty acyl-[mycocerosate synthase] + 6 NADPH <=> 3 CO2 + 3 CoA + 3 H2O + 6 NADP(+) + trimethylated-mycocerosoyl-[mycocerosate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31087", "l": "acetyl-CoA + octanoyl-CoA = 3-oxodecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9858590", "l": "DLST transfers glutaryl to CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9836500", "l": "IKK complex is activated by PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14169", "l": "ATP + CoA + glutarate = ADP + glutaryl-CoA + phosphate", "d": [], "t": []}, {"i": "EC:6.2.1.6", "l": "\"glutarate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-400143", "l": "Fatty acid ligands activate PPARA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29679", "l": "formate(in) = formate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419426", "l": "Cannabinoid receptors can bind cannabinoids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73757", "l": "Binding of RRN3 to RNA Polymerase I (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928627", "l": "EPHB phosphorylates TIAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641134", "l": "SMURF2 binds AXIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44720", "l": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45293", "l": "2-glyceryl-prostaglandin G2 + AH2 => 2-glyceryl-prostaglandin H2 + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44053", "l": "alpha,alpha-trehalose + hexadecanoyl-CoA => 2-O-hexadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1592316", "l": "Initial activation of proMMP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71401", "l": "OGDH dimer decarboxylates 2-OG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5220959", "l": "TDG excises 5-formylcytosine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19059", "l": "a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O => a hydroperoxy polyunsaturated fatty acid + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187697", "l": "TRKA recruits RIT and RIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174203", "l": "SCF-mediated degradation of Emi1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70837", "l": "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691439", "l": "BRISC complex deubiquitinates NLRP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674093", "l": "PDGFRs bind type I TKI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-994140", "l": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9656244", "l": "DRD2 binds DA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0009679", "l": "hexose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2197698", "l": "Src phosphorylate WASP,N-WASP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694077", "l": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68833", "l": "(2Z,6Z)-farnesyl diphosphate + H2O => (6Z)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11565", "l": "4-O-beta-D-glucopyranosyl-D-gluconate + phosphate => alpha-D-glucose 1-phosphate + D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8951951", "l": "RUNX3 binds EP300 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10516", "l": "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.166", "l": "\"hydroxycyclohexanecarboxylate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102047", "l": "indole-3-acetyl-glycine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) = H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052763", "l": "ulvan lyase activity", "d": ["Catalysis of the cleavage of a carbon-oxygen bond in ulvan, a carbohydrate composed of a repeating structure of [->4)-beta-D-GlcA-(1,4)-alpha-L-Rha 3S-(1->4)-alpha-L-IdoA-(1->4)-alpha-L-Rha 3S-(1-]n. Continued digest of ulvan with an enzyme that can catalyze this reaction results in ulvanobiouronic acid A 3-sulfate [->4)-beta-D-GlcpA-(1->4)-alpha-L-Rhap 3-sulfate-(1-]n with 4-deoxy-L-threo-hex-4-enopyranosiduronic acid at the non-reducing end."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37359", "l": "D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein] = D-glucosamine 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9825747", "l": "CREBBP acetylates HINT1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162195", "l": "COQ4 decarboxylates MHDB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.93", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21930", "l": "2,3-dioxo-L-gulonate + H(+) + NADPH => 3-dehydro-L-gulonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51727", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> adenosine 5'-tetraphosphate + ADP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003726", "l": "double-stranded RNA adenosine deaminase activity", "d": ["Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.554670414377497", "identifiers": [{"i": "GO:0001727", "l": "lipid kinase activity", "d": ["Catalysis of the phosphorylation of a simple or complex lipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22519", "l": "ATP + taurocyamine <=> ADP + H(+) + N-phosphotaurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13590", "l": "3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate => 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28109", "l": "galactitol 1-phosphate + NAD(+) <=> H(+) + keto-D-tagatose 6-phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34278", "l": "2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine <=> 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.4", "l": "\"glucose oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851890", "l": "MET phosphorylates SHC1-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78971", "l": "(2E)-3-methyl-5-phosphooxypent-2-enoate + H(+) = CO2 + isopentenyl phosphate", "d": [], "t": []}, {"i": "EC:4.1.1.126", "l": "\"anhydromevalonate phosphate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4093342", "l": "SDC2 multimerises (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-391934", "l": "DP2 receptor can bind PGD2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77233", "l": "(S)-2-hydroxypropylphosphonate + CMP + H(+) => cytidine 5'-({hydroxy[(S)-2-hydroxypropyl]phosphonoyl}phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.26.2", "l": "\"ribonuclease alpha\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39518", "l": "(2E,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH <=> (15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141040", "l": "very-long-chain 3-oxoacyl-CoA reductase activity", "d": ["Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + H+ + NADPH. This reaction is the second (reduction) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66659", "l": "Cu(2+)(out) + L-ascorbate(in) <=> Cu(+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69443", "l": "3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) <=> 3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76197", "l": "UDP-alpha-D-glucose(out) => UDP-alpha-D-glucose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9013143", "l": "RAC1 GEFs activate RAC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989746", "l": "Expression of CYP7A1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34230", "l": "5-nitrosalicylate + O2 <=> 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30345", "l": "FADH2 + fumarate => FAD + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26311", "l": "1,4-dihydroxy-2-naphthoate + CoA + H(+) => 1,4-dihydroxy-2-naphthoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2247510", "l": "MARCO:ligand is endocytosed (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021600", "l": "G-proteins dissociate from plasma-membrane estrogen receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036004", "l": "GAF domain binding", "d": ["Binding to a GAF protein domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807578", "l": "GNLY binds the bacterial cell surface in the phagosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5634221", "l": "TRAF1 binds TRAF2 within TNFR1 signaling complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66210", "l": "(2E,8R)-8-hydroxynonenoyl-CoA + H2O2 => (8R)-8-hydroxynonanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18187", "l": "5'-dehydroadenosine + H2O2 => adenosine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37827", "l": "(S)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 = 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-157906", "l": "Translocation of Cyclin E:Cdk2 complex to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66611", "l": "(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O <=> GpCpCpA + H(+) + tRNA 3'-end (ribonucleotide 3'-phosphate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72037", "l": "ATP(in) + 2 H(+)(in) + phosphate(out) => ATP(out) + 2 H(+)(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901531", "l": "hypochlorite binding", "d": ["Binding to hypochlorite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33196", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791130", "l": "Expression of CTDSP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57760", "l": "2 (S)-methylmalonyl-CoA + 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH = C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.65", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614662", "l": "FOXO1,FOXO3,(FOXO4) bind FASLG gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76743", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecane = 7-tetradecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59110", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol => chenodeoxycholate + octyl beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6786650", "l": "DDHD1,2 hydrolyse PA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23985", "l": "cholesterol + NADP(+) => 7-dehydrocholesterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38530", "l": "1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19020", "l": "(6S)-NADHX + ATP <=> ADP + H(+) + NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218823", "l": "PKC phosphorylates sphingosine kinase 1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68883", "l": "ATP + H(+) + NADPH + salicylate <=> AMP + diphosphate + NADP(+) + salicylaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16876", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA <=> (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1483063", "l": "PG and CDP-DAG are converted to CL by CRLS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23667", "l": "A + a (2R)-2-hydroxycarboxylate <=> a 2-oxocarboxylate + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28944", "l": "glycine betaine(in) => glycine betaine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31833", "l": "delta-guaiene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814165", "l": "PXLP-K333-GADL1 decarboxylates CSA to HTAU (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40654", "l": "1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43749", "l": "ATP + CoA + hexacosanoate => AMP + diphosphate + hexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140911", "l": "pore-forming activity", "d": ["An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death."], "t": []}, {"i": "TCDB:1.C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42912", "l": "cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.191", "l": "\"23S rRNA (cytosine(1962)-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001968", "l": "fibronectin binding", "d": ["Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75176", "l": "dATP + NAD(+) => dADP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688834", "l": "ATXN3 binds VCP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70481", "l": "TPI1 isomerizes GA3P to DHAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62803", "l": "2 7-demethylsiderin + NADPH + O2 <=> 2 H2O + NADP(+) + orlandin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75830", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] <=> (5S,18)-dihydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62235", "l": "a thymidine(6-4)thymidine in DNA <=> a thymidine dimer in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1168640", "l": "Ubiquitinated IkB is degraded (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51543", "l": "(S)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] <=> (S)-corytuberine + 2 H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222723", "l": "Nitric oxide is oxidized to nitrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30733", "l": "(2E)-butenoyl-CoA + FADH2 => butanoyl-CoA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043755", "l": "alpha-ribazole phosphatase activity", "d": ["Catalysis of the reaction: alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507749", "l": "PXLP-K341-GPT2 transaminates PYR to form L-Ala (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32424", "l": "(1R,4R)-dihydrocarvone + A => (R)-carvone + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9823934", "l": "OPTN binds TBK1 within the activated TLR4 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466832", "l": "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8940070", "l": "NT5E:Zn2+ hydrolyses NAD+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-975040", "l": "KRAB-ZNF / KAP Interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849348", "l": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1237096", "l": "Methylthio-ribose-P = Methylthio-ribulose-P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102456", "l": "cyanidin 3-O-glucoside 5-O-glucosyltransferase (sinapoyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-sinapoyl-beta-D-glucose = cyanin betaine + trans-sinapate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015306", "l": "sialate:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029449", "l": "Phosphorylation of SYK by Src kinases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856549", "l": "MLXIPL:MLX binds ACLY gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34107", "l": "glycine + H(+) + hexadecanoyl-CoA = 1-deoxymethyl-3-dehydrosphinganine + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14600", "l": "a CDP-1,2-diacyl-sn-glycerol + choline <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37876", "l": "aklanonate + S-adenosyl-L-methionine => methyl aklanonate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11421", "l": "NADPH + O2 + senecionine => H2O + NADP(+) + senecionine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8869206", "l": "PAFAH2 hydrolyses PAF to lyso-PAF and acetate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236941", "l": "Internalization of receptor bound antigen into clathrin coted vesicles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102367", "l": "2-alpha-hydroxytaxusin 7-beta-hydroxylase activity", "d": ["Catalysis of the reaction: 2alpha-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7beta-dihydroxytaxusin + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086061", "l": "voltage-gated sodium channel activity involved in bundle of His cell action potential", "d": ["Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49451", "l": "beta-D-Manp-(1->2)-beta-D-Manp-(1->2)-D-Manp + H2O <=> alpha-D-mannopyranose + beta-D-mannopyranosyl-(1->2)-D-mannopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46062", "l": "(5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52297", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018475", "l": "trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity", "d": ["Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44524", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoglycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645428", "l": "ALPK1 binds ADP-heptose (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683801", "l": "CHEK2 phosphorylates BRCA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570485", "l": "SUMOylation of Histone H4 with SUMO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-192061", "l": "CYP46A1 24-hydroxylates CHOL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204863", "l": "Interaction of Tie2 with Ang2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24233", "l": "2-dehydro-3-deoxy-D-gluconate + NAD(+) => 3-deoxy-D-glycero-2,5-hexodiulosonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388817", "l": "ICOS binds ICOSL/B7-H2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23123", "l": "a dipeptide(out) + ATP + H2O <=> a dipeptide(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052789", "l": "mannan 1,3-beta-mannosidase activity", "d": ["Catalysis of the hydrolysis of (1->3)-beta-D-mannosidic linkages in mannans, releasing mannose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66621", "l": "5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67662", "l": "a (8Z,11Z)-eicosadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => an (11Z)-eicosenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.38", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0004596", "l": "peptide alpha-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.12", "l": "\"xanthan lyase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27748", "l": "CO2 + cysteamine => H(+) + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44419", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35502", "l": "11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658424", "l": "KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11020", "l": "1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.127", "l": "\"inositol-trisphosphate 3-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.3", "l": "\"RNA ligase (ATP)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31268", "l": "6-hydroxyhexanoate + NADP(+) => 6-oxohexanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23047", "l": "H(+) + N,N-dihydroxy-L-tyrosine <=> (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190268", "l": "FGFR1c binds to Klotho-bound FGF23 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50215", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> 11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022063", "l": "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68548", "l": "O2 + psoralen + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + xanthotoxol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62850", "l": "GDP + H(+) + methyl 8-{[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP-beta-L-fucose + methyl 8-{[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696220", "l": "AS3MT transfers CH3 from AdoMet to arsenite(3-) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-197187", "l": "ACS transforms to QUIN non-enzymatically (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59806", "l": "D-phenylalanine => L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433711", "l": "Cis-homodimerization of nectins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633241", "l": "Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78153", "l": "a fatty acid + glycerol + H(+) => a 3-acyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130486", "l": "Uncoating of clathrin-coated vesicles and fusion with endosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4411402", "l": "Activation of NLK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5621370", "l": "SYK autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46238", "l": "a (5Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O => a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042937", "l": "tripeptide transmembrane transporter activity", "d": ["Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70286", "l": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66572", "l": "2-naphthol + 3'-phosphoadenylyl sulfate = 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8871266", "l": "YAP1 binds TEAD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75118", "l": "all-trans-13,14-dihydroretinol + NAD(+) <=> all-trans-13,14-dihydroretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38655", "l": "6-tuliposide B = D-glucose + tulipalin B", "d": [], "t": []}, {"i": "EC:4.2.99.23", "l": "\"tuliposide B-converting enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33581", "l": "H(+) + NADH + UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate => NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21251", "l": "a ribonucleoside 5'-triphosphate + RNA(n) <=> diphosphate + RNA(n+1)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44765", "l": "2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine => 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54780", "l": "[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine = [LarE protein]-dehydroalanine + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376419", "l": "Formation of NR-MED1 Coactivator Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5250930", "l": "B-WICH recruits histone acetyltransferases (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41572", "l": "lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626938", "l": "Beta-catenin binds SOX proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44782", "l": "H(+) + menaquinol-9 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-9 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51661", "l": "an N-(1,2-saturated acyl)sphinganine + H(+) + NADPH + O2 => an N-(2-hydroxyacyl)-sphinganine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9725706", "l": "SLC12A3 binds SLC12A3 inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57783", "l": "2-chloro-4-nitrotoluene + NADH + O2 <=> 3-chloro-4-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58641", "l": "a 5'-end 5'-phospho-ribonucleoside-RNA + 2 S-adenosyl-L-methionine => a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389762", "l": "Phosphorylation of PD-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24303", "l": "2 cob(I)yrinate a,c diamide + FMN + 3 H(+) <=> 2 cob(II)yrinate a,c diamide + FMNH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41809", "l": "(3R)-hydroxybutanoyl-[ACP] => (2E)-butenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75850", "l": "Addition of the third nucleotide on the nascent transcript (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31746", "l": "a 4'-hydroxyflavanone + S-adenosyl-L-methionine <=> a 4'-methoxyflavanone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983152", "l": "Transfer of ubiquitin from E1 to E2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951751", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2M (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14213", "l": "ATP + beta-D-fructose 1-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.56", "l": "\"1-phosphofructokinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9839105", "l": "AFG3L2 degrades mitochondrial matrix proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446195", "l": "DOLK phosphorylates DCHOL to DOLP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40738", "l": "(20S)-ginsenoside Rb1 + 2 H2O <=> 2 D-glucose + gypenoside LXXV", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3232162", "l": "PIAS3 SUMOylates MITF with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110350", "l": "Displacement of TDG glycosylase by APEX1 at the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47377", "l": "(25R)-3beta,26-dihydroxycholest-5-en-7-one + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-3beta-hydroxycholest-5-en-7-one-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-561253", "l": "SLC22A12 exchanges extracellular urate for cytosolic LACT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24023", "l": "2-(N(omega)-L-arginino)succinate <=> fumarate + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70501", "l": "PC carboxylates PYR to OA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17066", "l": "(R)-mevalonate + ATP => (R)-5-phosphomevalonate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45830", "l": "3-oxohexanoyl-CoA + H(+) + NADH => (3R)-hydroxyhexanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12195", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72200", "l": "Ca(2+)(in) + 2 H(+)(out) => Ca(2+)(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009905", "l": "ent-copalyl diphosphate synthase activity", "d": ["Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28867", "l": "H(+)(in) + lactose(in) = H(+)(out) + lactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50158", "l": "N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine => N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007606", "l": "E2F6 binds BRCA1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.343", "l": "\"phosphogluconate dehydrogenase (NAD(+)-dependent, decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186834", "l": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690997", "l": "Ligation of newly synthesized repair patch to incised DNA in GG-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47216", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6beta-hydroxyestradiol-17beta + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71034", "l": "L-cysteine(in) + L-phenylalanine(out) <=> L-cysteine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77840", "l": "(2S)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]pentanedioate + H(+) + H2O => 2-dehydro-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698003", "l": "FLT3 mutants phosphorylate GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046026", "l": "precorrin-4 C11-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21816", "l": "a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448629", "l": "IL33 binds IL1RL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61379", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O <=> 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49901", "l": "5,10-dihydrophenazine-1,6-dicarboxylate + O2 => H2O2 + phenazine-1,6-dicarboxylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39938", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O <=> (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39099", "l": "3-oxodecanedioyl-CoA + CoA = acetyl-CoA + octanedioyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432121", "l": "LDL binds to LRP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72989", "l": "myo-inositol(in) + 2 Na(+)(in) => myo-inositol(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020259", "l": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32974", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O <=> 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9632039", "l": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250220", "l": "Homodimerization of ERBB4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417843", "l": "P2Y13 binds ADP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69803", "l": "ATP + benzoate + H(+) = benzoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177942", "l": "EGFR binds EGF ligand (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78063", "l": "a triacylglycerol + all-trans-retinol = a 1,2-diacylglycerol + an all-trans-retinyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6814676", "l": "SNAPs and NSF hexamer bind cis-SNARE at the TGN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2022368", "l": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-42) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12754", "l": "glycerol + NADP(+) => dihydroxyacetone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.291", "l": "\"(R,S)-reticuline 7-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174367", "l": "GCL ligates L-Glu to L-Cys (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70757", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine => 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0004356", "l": "glutamine synthetase activity", "d": ["Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53086", "l": "[(1->2)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->2)-beta-D-glucosyl](n) + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688899", "l": "Defective CSF2RA does not bind SFTPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45964", "l": "5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 H2O = 2 AMP + ATP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189439", "l": "ALAD condenses 2 dALAs to form PBG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8851988", "l": "BTN2A2 binds T cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16062", "l": "H2O + sn-glycerol 3-phosphocholine => choline + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9645608", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32196", "l": "abieta-7,13-dien-18,18-diol => abieta-7,13-dien-18-al + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622325", "l": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8963851", "l": "VD3 dissociates from GC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158340", "l": "kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74517", "l": "aspoquinolone B => (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41960", "l": "a ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GA1 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0055056", "l": "D-glucose transmembrane transporter activity", "d": ["Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34911", "l": "D-methionine(in) = D-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21567", "l": "acetyl-CoA + an acyl-CoA <=> a 3-oxoacyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22756", "l": "a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54701", "l": "4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5692764", "l": "MAPK6 binds CCND3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371590", "l": "HSP70 binds to HSP40:nascent protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-139920", "l": "Translocation of tBID to mitochondria (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5627775", "l": "Autophosphorylation of PAK1,2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72669", "l": "2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + secoxyloganin => O2 + reduced [NADPH--hemoprotein reductase] + secologanin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8944232", "l": "Association of procollagen type XII (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3266557", "l": "Factor I cleaves iC3b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69018", "l": "5beta-pregnan-3,20-dione + H(+) + NADPH => 3alpha-hydroxy-5beta-pregnan-20-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9626832", "l": "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21796", "l": "dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.133", "l": "\"dTDP-4-dehydrorhamnose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050500", "l": "1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity", "d": ["Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102845", "l": "1-18:3-2-16:0-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-482804", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME4) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68559", "l": "NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine <=> H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30803", "l": "4-aminobutanal + H2O + NADP(+) = 4-aminobutanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810376", "l": "ING2 binds PI5P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-110011", "l": "Binding of Grb10 to the insulin receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67208", "l": "H2O + melatonin = 5-methoxytryptamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42064", "l": "ATP + GTP = 2',3'-cGAMP + 2 diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.86", "l": "\"cyclic GMP-AMP synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44034", "l": "9,10-dihydroxy-(12Z)-octadecenoate => 9,10-epoxy-(12Z)-octadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11904", "l": "2-amino-4-hydroxypteridine + H(+) + H2O = 2,4-dihydroxypteridine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2471842", "l": "Collagen type XXV ectomain shedding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856189", "l": "TNFSF8 binds TNFRSF8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46095", "l": "(25R)-cholest-5-ene-3beta,26-diol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta-hydroxy-5-cholesten-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62920", "l": "1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol = 1alpha,2beta,25-trihydroxycholecalciferol + 3-hydroxypropanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73718", "l": "UBF-1 Binds rDNA Promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68603", "l": "ORC5 binds ORC2:ORC3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0032559", "l": "adenyl ribonucleotide binding", "d": ["Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14211", "l": "diphosphate + UDP-alpha-D-galactose => alpha-D-galactose 1-phosphate + H(+) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51070", "l": "(3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine => (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66380", "l": "ATP + glutathione(in) + glycodeoxycholate(in) + H2O = ADP + glutathione(out) + glycodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16561", "l": "H2O + squalene = hopan-22-ol", "d": [], "t": []}, {"i": "EC:4.2.1.129", "l": "\"squalene--hopanol cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65270", "l": "chrodrimanin F + H2O + NADP(+) => 3-hydroxypentacecilide A + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56491", "l": "O2 + oleanolate + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hederagenin + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.10", "l": "\"bacterial leucyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429441", "l": "SYK activation by SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74735", "l": "S-adenosyl-L-methionine + syringetin = 7,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32718", "l": "(2R,3S)-3-methylmalate + NAD(+) <=> 2-oxobutanoate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65253", "l": "(2E,6E)-farnesyl diphosphate + 6-hydroxymellein => diphosphate + verruculide C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68175", "l": "2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2 <=> CO2 + H2O + isodomoate A + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204850", "l": "Interaction of Tie2 and Dok-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50132", "l": "ethyl hexadecanoate + H2O = ethanol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140840", "l": "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43001", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682388", "l": "Autophagosome maturation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70755", "l": "1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687109", "l": "8b binds MAP1LC3B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78627", "l": "L-cysteine + S-sulfanyl-L-cysteine = L-alanine + S-disulfanyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159179", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32719", "l": "L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27400", "l": "4'-demethylrebeccamycin + H2O <=> beta-D-glucose + dichloroarcyriaflavin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093332", "l": "p-EPHB phosphorylates SDC2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63550", "l": "angiotensin-(1-7) + L-phenylalanyl-L-histidine => angiotensin-(1-9) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548843", "l": "ACSL3,4 ligate CoA to AA to form AA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71249", "l": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14858", "l": "(indol-3-yl)acetate + ATP + L-lysine => ADP + H(+) + N(6)-[(indole-3-yl)acetyl]-L-lysine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170011", "l": "stalled ribosome sensor activity", "d": ["A molecule that recognizes stalled ribosomes and initiates a signaling response."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.32", "l": "\"17alpha-hydroxyprogesterone deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34977", "l": "(R)-pantothenate(out) => (R)-pantothenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607751", "l": "TRAF6 oligomerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41531", "l": "(2E)-octenoyl-[ACP] + H(+) + NADH <=> NAD(+) + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32721", "l": "(E)-5-(methylsulfanyl)pentanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => L-dihomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12374", "l": "4-oxohex-2-enedioate + H(+) => 2-(5-oxo-2,5-dihydrofuran-2-ylidene)acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16867", "l": "3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA => choloyl-CoA + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64836", "l": "2-phenylethanol + acetyl-CoA = CoA + phenethyl acetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395764", "l": "atREs binds to nascent CM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617758", "l": "EP300,CREBBP acetylate FOXO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61933", "l": "(S)-miconazole(in) + ATP + H2O => (S)-miconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.32", "l": "\"scytalidopepsin B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417842", "l": "P2Y10 receptor can bind to LPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824268", "l": "Expression of HES7 in presomitic mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10570", "l": "H(+) + luteolin 7-O-beta-D-glucuronide + UDP => luteolin + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68146", "l": "ethyl (R)-3-hydroxybutanoate + NADP(+) => ethyl 3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58489", "l": "4-(trimethylamino)butanoate + H(+) + NADH + O2 => H2O + NAD(+) + succinate semialdehyde + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55800", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2484822", "l": "Kinetochore assembly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42016", "l": "cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70496", "l": "D-glucose(out) + 2 Na(+)(out) => D-glucose(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71410", "l": "7beta-hydroxytaxusin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2alpha,7beta-dihydroxytaxusin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62357", "l": "8-oxo-GDP + H2O => 8-oxo-GMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70805", "l": "4-deoxy-4-sulfo-D-erythrose + D-xylulose 5-phosphate => 6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034859", "l": "benzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: benzothiazole + 1/2 O2 = 2-hydroxybenzothiazole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0015234", "l": "thiamine transmembrane transporter activity", "d": ["Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9835411", "l": "FA core complex:HSP70s binds PKR (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32692", "l": "(2E)-geranyl diphosphate => (E)-beta-ocimene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913374", "l": "Phosphorylated SHC1 recruits SHIP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57339", "l": "3-O-[beta-D-GlcA-(1->3)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose <=> 3-O-[alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2470935", "l": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450595", "l": "HuR:mRNA complex translocates from the nucleus to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849068", "l": "PTK6 phosphorylates ARHGAP35 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2559439", "l": "CD14:LPS binds CR3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35245", "l": "adenosine thiamine triphosphate + phosphate => ADP + H(+) + thiamine diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844860", "l": "ST3GAL5 transfers NeuNAc to ceramides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-977324", "l": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52472", "l": "16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159762", "l": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209823", "l": "Tyrosine is hydroxylated to dopa (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59706", "l": "D-cellohexaonate + H(+) => D-cellohexaono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14313", "l": "2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.26", "l": "\"iodophenol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052788", "l": "d-4,5 unsaturated beta-glucuronyl hydrolase activity", "d": ["Catalysis of the hydrolysis of the glycosidic bond in an unsaturated saccharide between the unsaturated glucuronyl residue at the nonreducing terminus and the saccharide linked to the residue."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110246", "l": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8854462", "l": "VLDLR binds VLDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129362", "l": "Fibrillin microfibril assembly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66183", "l": "(4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside(in) + ATP + H2O <=> (4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030591", "l": "2'-deoxyguanosine DNA ADP-ribosyltransferase activity", "d": ["Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62215", "l": "3-hydroxybenzyl alcohol + O2 + reduced [NADPH--hemoprotein reductase] <=> gentisyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692315", "l": "OX40L binds OX40 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8984014", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38905", "l": "a sphingomyelin(out) + ADP + H(+) + phosphate => a sphingomyelin(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-351963", "l": "SLC6A18 transports Gly from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40127", "l": "an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612980", "l": "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39343", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA = (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60951", "l": "(S)-eriodictyol + S-adenosyl-L-methionine <=> (S)-homoeriodictyol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27715", "l": "GMP + H2O => guanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029451", "l": "Activation of RAC1 by VAV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855232", "l": "RELN:VLDLR binds DAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77753", "l": "(4E,11E)-2-hydroxytrideca-4,11-dien-1,2,3-tricarboxylate + CoA + H(+) => (2E,10E)-dode-2,10-dicenoyl-CoA + H2O + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028635", "l": "Phosphorylation of MOB1A and B by p-STK3 (p-MST2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19666", "l": "6-carboxyhexanoyl-CoA + NAD(+) => 6-carboxyhex-2-enoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57836", "l": "H2O + O2 + thermospermine = 3-aminopropanal + H2O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39597", "l": "(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + NADP(+) => (2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015611", "l": "ABC-type D-ribose transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) = ADP + phosphate + D-ribose(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174391", "l": "MAT1A multimers transfer Ado from ATP to L-Met (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676595", "l": "TRAFs bind RANK:RANKL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15426", "l": "coproporphyrinogen III + 2 S-adenosyl-L-methionine => 2 5'-deoxyadenosine + 2 CO2 + 2 L-methionine + protoporphyrinogen IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64374", "l": "alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine => beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75893", "l": "CoA + pseudomonic acid C--holothin => holothin + pseudomonoyl-CoA C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70201", "l": "5,6-dihydroxyindole => dopaminechrome", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730902", "l": "Oligomerization of p-CARMA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11796", "l": "ecdysone + O2 = 3-dehydroecdysone + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.16", "l": "\"ecdysone oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420977", "l": "Ca permeable AMPA receptor ligand binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75721", "l": "4'-phosphopantetheinyl-CoA disulfide + adenosine 3',5'-bisphosphate + 2 H(+) => CoA-disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353472", "l": "Displacement of DNA glycosylase and endonucleolytic cleavage by DNA-lyase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72252", "l": "(R)-adrenaline + S-adenosyl-L-methionine => (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0004555", "l": "alpha,alpha-trehalase activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-481010", "l": "Surface deployment of platelet dense granule membrane components (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21613", "l": "D-gluconate => 2-dehydro-3-deoxy-D-gluconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696997", "l": "USP24 deubiquitinates DDB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951966", "l": "EP300 acetylates RUNX3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295519", "l": "IL7R is phosphorylated on Y499 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050615", "l": "1,2-dihydrovomilenine reductase activity", "d": ["Catalysis of the reaction: 17-O-acetylnorajmaline + NADP+ = 1,2-dihydrovomilenine + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68606", "l": "H(+) + hydroxyacetone + sulfite => (2S)-3-sulfopropanediol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2424484", "l": "Phosphorylation of BTK by p-SYK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9843990", "l": "HUSH complex binds LINE1 (L1) RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809778", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72201", "l": "Ca(2+)(out) + 2 H(+)(in) => Ca(2+)(in) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57431", "l": "anisole + O2 + reduced [NADH--hemoprotein reductase] <=> formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019780", "l": "FAT10 activating enzyme activity", "d": ["Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106261", "l": "tRNA uridine(34) acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H+ + L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53238", "l": "(24Z),26-hydroxydesmosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => desmosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75300", "l": "NAD(+) => 2'cADPR + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5334827", "l": "SUMO-CRABP2 binds atRA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69615", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48611", "l": "A + a 2,3-saturated acyl-CoA <=> a 2,3-dehydroacyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16180", "l": "H2O + NAD(+) + retinal <=> 2 H(+) + NADH + retinoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296348", "l": "Activation of TWIK-related K+ channel (TREK) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36118", "l": "gibberellin A3 + S-adenosyl-L-methionine <=> O-methyl gibberellin A3 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9660615", "l": "Defective RB1 does not translocate to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-400586", "l": "G alpha (q) binds to Trio family RhoGEFs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-168848", "l": "tBID binds to inactive BAK protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36770", "l": "2-hydroxytetracosenoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139905", "l": "Translocation of activated BAD protein to mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9018774", "l": "RHOBTB1 binds GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40488", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77703", "l": "a ganglioside GA1 (d18:1(4E)) + GDP-beta-L-fucose = a ganglioside Fuc-GA1 (d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65621", "l": "hexadecanoyl-CoA + sphinga-(4E,8E)-dienine => CoA + H(+) + N-hexadecanoylsphinga-(4E,8E)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.5", "l": "\"nucleoside ribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44872", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.6.-", "l": "\"With a nitrogenous group as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661425", "l": "BIL:ALB dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47895", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine <=> GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->6)-N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-266050", "l": "LTA4 is converted to LTC4 by LTC4S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63882", "l": "cyanate + 2 Fe(II)-[cytochrome c] + 2 H(+) + sulfur => 2 Fe(III)-[cytochrome c] + H2O + thiocyanate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61721", "l": "a D-guloside + NAD(+) => a 3-dehydro-D-guloside + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033914", "l": "xylan 1,3-beta-xylosidase activity", "d": ["Catalysis of the hydrolysis of successive xylose residues from the non-reducing termini of (1->3)-beta-D-xylans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25241", "l": "(S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.3.26", "l": "\"(S)-ureidoglycine aminohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52826", "l": "(4R,7R)-4-isopropenyl-7-methyloxepan-2-one + H2O + NADP(+) => (1R,4R)-dihydrocarvone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0031711", "l": "bradykinin receptor binding", "d": ["Binding to a bradykinin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76376", "l": "3 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) => 3 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25137", "l": "H2O + pyridoxamine 5'-phosphate => phosphate + pyridoxamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19816", "l": "a 2-oxocarboxylate + L-asparagine <=> 2-oxosuccinamate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71209", "l": "iodide(in) + 2 Na(+)(in) => iodide(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64731", "l": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 <=> (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.35", "l": "\"gelatinase B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36178", "l": "1-O-alkylglycerone 3-phosphate + H(+) + NADPH <=> 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028724", "l": "AMOT proteins bind YAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11927", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose <=> a globoside Gb3Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35089", "l": "D-glucosamine + N-acetyl-D-glucosamine 6-phosphate => H2O + N'-monoacetylchitobiose-6'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43088", "l": "5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47906", "l": "ADP + H(+) + N-(acetyl)-sphing-4-enine-1-phosphate => ATP + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034007", "l": "S-linalool synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = (S)-linalool + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183122", "l": "Factor D cleaves C3b-bound Factor B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31392", "l": "15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) => all-trans-4,4'-diapolycopene + 4 FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71775", "l": "SUCLG1/G2 cleaves succinyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48510", "l": "3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH => cholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983158", "l": "Trimming of peptides in ER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700154", "l": "Active ALK binds SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047977", "l": "hepoxilin-epoxide hydrolase activity", "d": ["Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034317", "l": "nicotinic acid riboside kinase activity", "d": ["Catalysis of the reaction: ATP + nicotinic acid riboside = ADP + nicotinic acid mononucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052849", "l": "NADPH-dependent curcumin reductase activity", "d": ["Catalysis of the reaction: curcumin + NADPH + H+ = dihydrocurcumin + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956684", "l": "ITCH polyubiquitinates TP73 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603984", "l": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24895", "l": "5-hydroxyxanthotoxin + S-adenosyl-L-methionine => isopimpinellin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374723", "l": "Nociceptin receptor binds to nociceptin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11980", "l": "2 gamma-L-glutamyl-L-cysteine + NADP(+) = bis-gamma-glutamylcystine + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.8.1.13", "l": "\"bis-gamma-glutamylcystine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9733960", "l": "Bile salts and acids dissociate from ALB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139854", "l": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166214", "l": "FA anion flip-flops to the opposite surface (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34200", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 => bracteatin 6-O-beta-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209821", "l": "Methylation of N-acetyl-5-HT to form melatonin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40702", "l": "1-hexadecanoylglycerone 3-phosphate + octadecan-1-ol <=> 1-O-octadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5651773", "l": "LIG1 binds POLB at long-patch BER site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9626914", "l": "α2-agonists bind ADRA2A,B,C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54981", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956586", "l": "RUNX1-containing TAL1 complex binds the MYB gene enhancer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138433", "l": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74841", "l": "UDP(out) + UDP-alpha-D-glucuronate(in) => UDP(in) + UDP-alpha-D-glucuronate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33507", "l": "sphing-4-enine 1-phosphate = (2E)-hexadecenal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32091", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine = dTDP + erythromycin D + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.278", "l": "\"3-alpha-mycarosylerythronolide B desosaminyl transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446391", "l": "Formation of the PINCH-ILK-parvin complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56773", "l": "2 AH2 + all-trans-adonixanthin + 2 O2 => 2 A + all-trans-(3S,3'S)-astaxanthin + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1454916", "l": "The ABCC family mediates organic anion transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391155", "l": "SIRPA binds SFTPA oligomer, SFTPD oligomer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62173", "l": "an N-acylethanolamine phosphate + H2O => an N-acylethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58723", "l": "(S)-nicotine + NADPH + O2 <=> H2O + NADP(+) + trans-(S)-nicotine N(1')-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3371531", "l": "Constitutive phosphorylation  by pERK1/2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56593", "l": "a disubstituted aliphatic (S)-hydroxynitrile => a ketone + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20257", "l": "3-methyloxindole + NADP(+) = 3-methyleneoxindole + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.17", "l": "\"3-methyleneoxindole reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854255", "l": "TBC1D2A accelerates GTP hydrolysis by RAB7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76439", "l": "19-hydroxy-11-deoxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 19-oxo-11-deoxycorticosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932765", "l": "NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53619", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-isoafricanol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140929", "l": "mannose:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-mannose(out) + Na+(out) = D-mannose(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73568", "l": "ITP(out) + UTP(in) => ITP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174916", "l": "Formation of N-glucuronides (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54885", "l": "L-arginyl-[protein] + NADP(+) => H(+) + N(omega)-(2'-phospho-ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9021357", "l": "PRKCI phosphorylates ELF3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875374", "l": "MET binds LRIG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.99.-", "l": "\"In other compounds\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634729", "l": "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15160", "l": "4-hydroxyphenylacetate + H(+) + NADPH + O2 <=> H2O + homogentisate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15118", "l": "3'-dephospho-CoA + ATP => 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65222", "l": "catechol + H(+) + NADPH => (1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64708", "l": "butan-1-ol + NADP(+) = butanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158766", "l": "fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63153", "l": "an N-fatty acyl-taurine + H2O => a fatty acid + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34827", "l": "H(+) + N-acyl-15-methylhexadecasphinganine + NADPH + O2 = H2O + N-acyl-4-hydroxy-15-methylhexadecasphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18672", "l": "adenosine + H2O <=> adenine + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483159", "l": "PCho is dephosphorylated to Cho by PHOSPHO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831017", "l": "Expression of GREM1 in metanephric mesenchyme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420052", "l": "Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629675", "l": "PDE3A hydrolyses cAMP to AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211206", "l": "Translocation of DFF to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16847", "l": "citrate + CoA + H(+) => acetyl-CoA + H2O + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205075", "l": "JNK phosphorylates BIM, BAD and other targets (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2230938", "l": "Hemoglobin:Haptoglobin:CD163 is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27515", "l": "H2O + sphinganine 1-phosphate => phosphate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977363", "l": "Factor H binds to C3bBb (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102447", "l": "rhamnetin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine = 7,3'-dimethylquercetin + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1363331", "l": "Ubiquitination of p130 (RBL2) by SCF (Skp2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36329", "l": "diphosphate + N(6)-(dimethylallyl)adenosine 5'-diphosphate => ADP + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173754", "l": "Properdin stabilizes C3b:Bb bound to cell surfaces (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42429", "l": "clavaminate => (3R,5R)-clavulanate-9-aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55412", "l": "[phosphate](n) + GTP = [phosphate](n+1) + GDP", "d": [], "t": []}, {"i": "EC:2.7.4.34", "l": "\"GDP-polyphosphate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68619", "l": "cortisone + H(+) + NADPH <=> cortisol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8939201", "l": "ESR dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9909159", "l": "HK1 phosphorylates Mannose to Man6P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2002440", "l": "Removal of fibrillar collagen C-propeptides (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69102", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine => 4-methylsulfanyl-2-oxobutanoate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928619", "l": "PAK1 binds RAC1:GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23864", "l": "4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP", "d": [], "t": []}, {"i": "EC:4.6.1.12", "l": "\"2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5340195", "l": "NR1H4 binds DCA, CDCA, LCHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23321", "l": "D-tryptophan + malonyl-CoA => CoA + H(+) + N(2)-malonyl-D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77104", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O => 2-(9Z-octadecenoyl)-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53565", "l": "9,10-epoxy-(12Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-9,10-epoxy-(12Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168642", "l": "SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0098809", "l": "nitrite reductase activity", "d": ["Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74541", "l": "creatinine(out) => creatinine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944104", "l": "PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56169", "l": "(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001093", "l": "TFIIB-class transcription factor binding", "d": ["Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674366", "l": "IL17RD binds p-2S MAP2Ks and MAPKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68252", "l": "L-tryptophan(in) + Na(+)(in) = L-tryptophan(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24505", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 => 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5656158", "l": "POLZ elongates POLI-incorporated dNMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2167942", "l": "Collagen type XIII ectodomain shedding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44083", "l": "ATP + CoA + undecanoate <=> AMP + diphosphate + undecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211959", "l": "CYP3A43 6b-hydroxylates TEST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664855", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60410", "l": "Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine] + N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine => Fe(III)-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78842", "l": "[DsrC protein]-dithiol + 2 a quinone + 2 H(+) + hydrogen sulfide <=> [DsrC protein]-trisulfide + 2 a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097259", "l": "20-aldehyde-leukotriene B4 20-monooxygenase activity", "d": ["Catalysis of the reaction: 20-oxo-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H+ + H2O + oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8963915", "l": "1,25(OH)2D binds VDR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58731", "l": "adenosine in rRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141185", "l": "UFM1-modified protein reader activity", "d": ["A molecular adaptor recognizes and binds a target protein containing a UFM1 modification and brings the target protein into contact with another protein to allow those proteins to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48768", "l": "ATP + D-erythrulose = ADP + D-erythrulose 4-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.210", "l": "\"D-erythrulose 4-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50467", "l": "4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 24 H(+) + 8 malonyl-CoA + 16 NADPH <=> 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 8 CoA + 8 H2O + 16 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696670", "l": "CHD1L is recruited to GG-NER site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5655481", "l": "USP1:WDR48 binds monoUb:K164-PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420083", "l": "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44972", "l": "(R)-carnitine + hexanoyl-CoA = CoA + O-hexanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9833777", "l": "PKR binds activating host RNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8874979", "l": "ACBD3 binds GOLGB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33979", "l": "DIBOA beta-D-glucoside + H2O = D-glucose + DIBOA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30505", "l": "acetate + L-glutamate 5-semialdehyde => H2O + N-acetyl-L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052919", "l": "aliphatic (R)-hydroxynitrile lyase activity", "d": ["Catalysis of the reaction: an aliphatic (R)-hydroxynitrile = an aliphatic aldehyde or ketone + hydrogen cyanide."], "t": []}, {"i": "RHEA:28170", "l": "(2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide", "d": [], "t": []}, {"i": "EC:4.1.2.46", "l": "\"aliphatic (R)-hydroxynitrile lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17955", "l": "(2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde => 3-hydroxyanthranilate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169394", "l": "ISGylation of IRF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388560", "l": "EDNRA,EDNRB bind EDNs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36301", "l": "(E)-caffeoyl-CoA + AMP + diphosphate => (E)-caffeate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14656", "l": "a nucleoside 3',5'-cyclic phosphate + H2O <=> a nucleoside 5'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.58", "l": "\"heme oxygenase (biliverdin-IX-beta and delta-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26545", "l": "(R)-piperazine-2-carboxamide + H2O <=> (R)-piperazine-2-carboxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33535", "l": "H2O + lanosteryl ester = a carboxylate + H(+) + lanosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11298", "l": "2-oxoglutarate + 2 H(+) + NADPH => 2,5-dioxopentanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6809309", "l": "MTMR6 binds MTMR9 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9750946", "l": "TRAF2,6 ubiquitinates NLRC5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610154", "l": "Dissociation of phosphorylated MAP2Ks and MAPKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65842", "l": "ATP(in) + Mg(2+)(in) + phosphate(out) => ATP(out) + Mg(2+)(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444008", "l": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021050", "l": "HSBP1 oligomer binds ESRs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021451", "l": "NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73828", "l": "adenylosuccinate => adenosine 5'-monophosphate + fumarate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57243", "l": "glyoxal + GMP <=> N(2)-(1-hydroxy-2-oxoethyl)-GMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15567", "l": "a carboxylate + an L-alpha-amino acid => an N-acyl-L-amino acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2466068", "l": "Phosphorylation of cohesin by PLK1 at chromosomal arms (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38097", "l": "alpha-tocotrienol + H(+) + S-adenosyl-L-homocysteine => gamma-tocotrienol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649883", "l": "POLB-mediated DNA strand displacement synthesis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9671145", "l": "DKC1 binds SHQ1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68464", "l": "2-butyloctyl sulfate + H2O = 2-butyloctan-1-ol + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.22", "l": "\"branched primary-alkylsulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14200", "l": "ATP + L-aspartate + NH4(+) <=> ADP + H(+) + L-asparagine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50054", "l": "ADP + H(+) + phosphate + taurocholate(out) => ATP + H2O + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52683", "l": "acetyl-CoA + L-alpha-phenylglycine <=> CoA + H(+) + N-acetyl-L-alpha-phenylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196929", "l": "FLAD1 phosphorylates FMN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14032", "l": "A + H2O + selenite <=> AH2 + selenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205319", "l": "Interaction of APS and p-KIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31777", "l": "11-cis-retinol + H(+) + hexadecanoate => all-trans-retinyl hexadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38291", "l": "(S)-malyl-CoA + H2O = (S)-malate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.30", "l": "\"(3S)-malyl-CoA thioesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56376", "l": "3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 = 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9753284", "l": "ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65681", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontenoyl)-sphing-4-enine => a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75379", "l": "H2O + L-canavanine = L-homoserine + N-hydroxyguanidine", "d": [], "t": []}, {"i": "EC:4.4.1.43", "l": "\"canavanine-gamma-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9667456", "l": "AVPR1A,B bind desmopressin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25921", "l": "A + H2O + quinolin-7-ol => 7-hydroxyquinolin-2(1H)-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11141", "l": "alpha-D-mannose 1-phosphate => D-mannose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6783556", "l": "LIFR:JAKs bind gp130:JAKs:CNTFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70692", "l": "ornithine => putrescine + CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-203700", "l": "eNOS translocation from Golgi to Caveolae (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046922", "l": "peptide-O-fucosyltransferase activity", "d": ["Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093331", "l": "Ras:GTP binds p120-RasGAP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114392", "l": "Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015311", "l": "monoamine:proton antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29466", "l": "K(+)(in) <=> K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50954", "l": "A + CO2 + 2 H2O + monodechloroaminopyrrolnitrin => 7-chloro-L-tryptophan + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58582", "l": "acetate + catharanthine + H(+) => dihydroprecondylocarpine acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70048", "l": "2-oxoadipate + L-kynurenine => H2O + kynurenate + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55193", "l": "2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 => 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654605", "l": "Activated FGFR2 phosphorylates FRS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373741", "l": "SDK2 homophillic interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416358", "l": "G alpha (q) inhibits PI3K alpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661408", "l": "FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70971", "l": "ACO2 isomerizes citrate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55037", "l": "an N,N-dimethylornithine lipid + S-adenosyl-L-methionine => an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707827", "l": "Spike binds Spike inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8858475", "l": "TNFSF9 binds TNFRSF9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73154", "l": "CoA(out) + FMN(in) <=> CoA(in) + FMN(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57357", "l": "2-oxoglutarate + chloride + H(+) + hapalindole U + O2 => CO2 + H2O + hapalindole G + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.220", "l": "\"ipecoside beta-D-glucosidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678315", "l": "BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754480", "l": "p-2S-SMAD2,3:SMAD4, CTNNB1, and TBPL2 bind FOXH1:SMAD3:EOMES gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44932", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24015", "l": "gamma-tocopherol + S-adenosyl-L-methionine <=> (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035236", "l": "proctolin receptor activity", "d": ["Combining with the neuropeptide proctolin, to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31431", "l": "(2E,6E)-farnesyl diphosphate = (-)-beta-santalene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.83", "l": "\"beta-santalene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004998", "l": "transferrin receptor activity", "d": ["Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69685", "l": "CHEK2 phosphorylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44767", "l": "2-methoxy-6-all-trans-decaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6810233", "l": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869606", "l": "NMRK1 phosphorylates NAR to yield NAMN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61858", "l": "betaenone C + 3 H2O + 3 NADP(+) => dehydroprobetaenone I + 3 H(+) + 3 NADPH + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53648", "l": "(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether A + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.171", "l": "\"(+)-corvol ether A synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12905", "l": "alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate", "d": [], "t": []}, {"i": "EC:2.7.7.22", "l": "\"mannose-1-phosphate guanylyltransferase (GDP)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46325", "l": "3-oxochol-4-en-22-oyl-CoA + A => 3-oxochola-4,17-dien-22-oyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20644", "l": "H2O + L-histidinol + 2 NAD(+) <=> 3 H(+) + L-histidine + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54346", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74173", "l": "an alcohol + CO2 + methylamine => an N-methyl carbamate ester + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26460", "l": "acetaldehyde + FMN + 2 H(+) + H2O + nitrite => ethylnitronate + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013024", "l": "RHOB binds effectors at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60208", "l": "3 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 O2 = 3 CO2 + 3 formaldehyde + L-lysyl(4)-[histone H3] + 3 succinate", "d": [], "t": []}, {"i": "EC:1.14.11.67", "l": "\"[histone H3]-trimethyl-L-lysine(4) demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65342", "l": "CoA + O-acetyl-L-threonyl-[protein] => acetyl-CoA + L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400183", "l": "PPARA:RXRA binds Corepressors of PPARA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41750", "l": "1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55159", "l": "a quinone + glutathione + H(+) + hydrogen sulfide <=> a quinol + S-sulfanylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4837364", "l": "Secretion of SOD3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10556", "l": "D-glyceraldehyde 3-phosphate + L-arginine = H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.66", "l": "\"N(2)-(2-carboxyethyl)arginine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655483", "l": "USP1 autocleavage (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57695", "l": "2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)inamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59715", "l": "D-maltotetraono-1,5-lactone + H2O <=> D-maltotetraonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33482", "l": "an acyl-CoA + lanosterol <=> CoA + lanosteryl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76658", "l": "3-methylbutanal + H2O + NAD(+) <=> 3-methylbutanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8938231", "l": "RUNX1:CBFB binds CREBBP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419841", "l": "Light stimulates opsin receptors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004307", "l": "ethanolaminephosphotransferase activity", "d": ["Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58090", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoate + glycerol + H(+) => 1-(7Z,10Z,13Z,16Z-docosatetraenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70717", "l": "glycine(out) => glycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444120", "l": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637801", "l": "Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55937", "l": "all-trans-4-hydroxyretinol + NAD(+) => all-trans-4-hydroxyretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855171", "l": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676268", "l": "Formation of the MLL4 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47098", "l": "(2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate => (2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45765", "l": "H2O + L-aspartate 4-semialdehyde + NAD(+) => 2 H(+) + L-aspartate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9757954", "l": "N4BP1 binds IKBKG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.39", "l": "\"malate dehydrogenase (decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72993", "l": "2 Na(+)(in) + scyllo-inositol(in) => 2 Na(+)(out) + scyllo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706308", "l": "Active FLT3 binds to GRB10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60194", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50479", "l": "anthraniloyl-CoA + L-cysteinyl-[PqsD protein] <=> CoA + S-anthraniloyl-L-cysteinyl-[PqsD protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2130731", "l": "Formation of COPII vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13304", "l": "a 1,2-diacyl-sn-glycerol + a sterol <=> a 1-acyl-sn-glycerol + a sterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61115", "l": "(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] <=> (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6810076", "l": "DDO oxidizes D-Asp to OA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16498", "l": "adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine => H(+) + N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44279", "l": "eicosanoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxohenicosyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32828", "l": "ATP + H2O + methionine(out) => ADP + H(+) + methionine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199131", "l": "PVR binds CD226 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194674", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56225", "l": "3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-{beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59827", "l": "2-oxoglutarate + pyridoxamine 5'-phosphate <=> L-glutamate + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68890", "l": "2-methoxybenzaldehyde + AMP + diphosphate + NADP(+) => 2-methoxybenzoate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69781", "l": "(2-oxoindol-3-yl)acetyl-CoA + succinate => 2-oxindole-3-acetate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5578744", "l": "Importin-8 imports AGO2:miRNA into the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22525", "l": "2 A + a carotenoid beta-end derivative => a carotenoid phi-end derivative + 2 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448958", "l": "Nuclear translocation of p38 MAPK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22205", "l": "3-hydroxyphenylacetate + H(+) + NADPH + O2 => H2O + homogentisate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2288097", "l": "Condensin II complex binds H4K20me1-containing nucleosomes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49772", "l": "glycine + hexacosanoyl-CoA = CoA + H(+) + N-hexacosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167089", "l": "Recognition and binding of the HIV-1 mRNA cap by the cap-binding complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187330", "l": "PARP1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102772", "l": "sphingolipid C4-monooxygenase activity", "d": ["Catalysis of the reaction: a dihydroceramide + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = a phytoceramide + 2 Fe(III)-[cytochrome b5] + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77637", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-3-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38914", "l": "avenacoside B + H2O <=> 26-desgluco-avenacoside B + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37053", "l": "ATP + chlorophyllide a + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin] => 3-deacetyl-3-vinylbacteriochlorophyllide a + ADP + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5250947", "l": "B-WICH complex binds rDNA promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27572", "l": "ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+) => ATP + D-glycero-alpha-D-manno-heptose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66320", "l": "2',3'-cGAMP(out) = 2',3'-cGAMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3465459", "l": "FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683488", "l": "ACE2 is glycosylated to glycosylated-ACE2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022870", "l": "protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938913", "l": "RUNX1 binds ELF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33041", "l": "2-oxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] => 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76325", "l": "L-aspartate(out) + L-valine(in) => L-aspartate(in) + L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68387", "l": "(2E,6E)-farnesyl diphosphate + L-tryptophyl-[protein] <=> (2S,3R)-3-farnesyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophyl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029454", "l": "Autophosphorylation of PAK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44559", "l": "4-hydroxybenzoate + all-trans-hexaprenyl diphosphate <=> 4-hydroxy-3-all-trans-hexaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31248", "l": "H(+) + prop-2-ynal + pyrroloquinoline quinol => prop-2-yn-1-ol + pyrroloquinoline quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15965", "l": "1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52592", "l": "deoxycholoyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60269", "l": "N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018756", "l": "RHOH binds GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8848663", "l": "ADIPOQ trimer binds ADIPOR dimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31324", "l": "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose => (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55371", "l": "(R)-carnitine + H(+) + NADPH + O2 <=> (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62344", "l": "6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate = diphosphate + notoamide S", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19615", "l": "S-adenosyl-L-homocysteine + trimethylsulfonium => dimethyl sulfide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76472", "l": "Ethylene is oxidized to Ethylene oxide by CYP1A1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73577", "l": "(E,E)-piperoyl-AMP + diphosphate => (E,E)-piperate + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015148", "l": "D-xylose transmembrane transporter activity", "d": ["Enables the transfer of D-xylose from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64700", "l": "1-phenylethanol + NAD(+) = acetophenone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855259", "l": "RELN:VLDLR:DAB1 binds SH3KBP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2428930", "l": "IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76184", "l": "2 H(+)(out) + L-alanyl-L-alanine(out) => 2 H(+)(in) + L-alanyl-L-alanine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75848", "l": "ACLY tetramer transforms CIT to Ac-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19954", "l": "a 2-oxocarboxylate + L-alanine => an L-alpha-amino acid + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17652", "l": "acetyl-[ACP] + malonate <=> acetate + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73352", "l": "ATP + beta-alanine + histamine => AMP + carcinine + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68119", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol <=> a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33860", "l": "(2S-3S)-versiconal hemiacetal => H2O + versicolorin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77899", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-6-aminohexanoate + O2 = (1-deoxy-D-fructos-1-yl)amine + 6-oxohexanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76457", "l": "(E)-coniferaldehyde + AH2 => (E)-coniferol + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213239", "l": "Formation of MHC II alpha beta heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114671", "l": "vWF binds to collagen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57654", "l": "a ganglioside GM1alpha + CMP + H(+) => a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57442", "l": "2-hydroxytoluene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] => 2-methylanisole + O2 + reduced [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37597", "l": "1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + nonadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625346", "l": "SREBF1 gene expression is inhibited by FOXO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49216", "l": "3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + H2O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.103", "l": "\"3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47688", "l": "cis-4-hydroxy-L-proline + NADP(+) = Delta(1)-pyrroline-(4S)-hydroxy-2-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9033961", "l": "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682598", "l": "ATM phosphorylates HERC2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993814", "l": "HLCS biotinylates ACACA:Mn2+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781905", "l": "ZRANB1 binds APC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158609", "l": "TPMT transfers CH3 from AdoMet to 6MP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12544", "l": "2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate", "d": [], "t": []}, {"i": "EC:6.3.5.9", "l": "\"hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78337", "l": "2',3'-cUAMP + 2 diphosphate => ATP + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875374", "l": "MET binds LRIG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867047", "l": "PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200318", "l": "creatine + ATP => phosphocreatine + ADP [CKB,CKM] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004090", "l": "carbonyl reductase (NADPH) activity", "d": ["Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44831", "l": "(R)-carnitine + decanoyl-CoA <=> CoA + O-decanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11113", "l": "H2O + isochorismate => (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59485", "l": "arsenite + 2 Fe(III)-[cytochrome c] + H2O => arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59780", "l": "L-histidine + S-adenosyl-L-methionine = (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56060", "l": "H(+) + hexadecanoate + hnu = CO2 + pentadecane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76826", "l": "H2O + methylamine + NAD(+) <=> formaldehyde + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64284", "l": "2-phenylethylamine + pyruvate = 2-phenylacetaldehyde + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071253", "l": "connexin binding", "d": ["Binding to a connexin, any of a group of related proteins that assemble to form gap junctions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37332", "l": "H2O + L-methionyl-L-alanine => L-alanine + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693346", "l": "CECRI deaminates Ade-Rib to Ino (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51891", "l": "2,3,5,6-tetrachlorohydroquinone + H(+) + NAD(+) <=> 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676065", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74737", "l": "7,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + syringetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9757954", "l": "N4BP1 binds IKBKG (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.34", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15847", "l": "4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP => 4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40292", "l": "ATP + CoA + tetradecanedioate => AMP + diphosphate + tetradecanedioyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30443", "l": "2 glycyl-tRNA(Gly) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)", "d": [], "t": []}, {"i": "EC:2.3.2.18", "l": "\"N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67895", "l": "3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine <=> 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71691", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42880", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermine = H(+) + N(4)-aminopropylspermine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16522", "l": "H(+) + NAD(+) + 2 reduced [2Fe-2S]-[ferredoxin] => NADH + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15830", "l": "a 16alpha-hydroxysteroid => a 16beta-hydroxysteroid", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64252", "l": "glycine + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110364", "l": "PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36870", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13206", "l": "a monosaccharide 1-phosphate + H(+) + UTP => a UDP-monosaccharide + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55438", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + salviol => ferruginol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11543", "l": "an N-acyl-D-mannosamine + NAD(+) <=> an N-acyl-D-mannosaminolactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076611", "l": "HS3STs sulfate GlcN at C3 in heparan sulfate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70447", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in single-stranded DNA + O2 = a 2'-deoxyadenosine in single-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11402", "l": "4'-O-demethylsordarin + GDP + H(+) => GDP-6-deoxy-alpha-D-altrose + sordaricin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0031701", "l": "angiotensin receptor binding", "d": ["Binding to an angiotensin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-376357", "l": "Vamp7 associated Lysosome to Plasma membrane transport (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5691004", "l": "XPC binds RAD23 and CETN2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018807", "l": "RAC3 GDIs block activation of RAC3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64312", "l": "2 chloride + 2 FADH2 + 2 O2 + sulochrin = dihydrogeodin + 2 FAD + H(+) + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450620", "l": "p-S193-KSRP binds 14-3-3zeta in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683836", "l": "SFTPC gene produces pro-SFTPC protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "61.166478714665431", "identifiers": [{"i": "GO:0016810", "l": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds", "d": ["Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9691566", "l": "KCNJ11:ABCC9 binds nicorandil (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167983", "l": "C-ter TLR7 dimer binds TLR7, TLR8 ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200424", "l": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72601", "l": "N-acetyl-L-aspartyl-L-glutamate(in) => N-acetyl-L-aspartyl-L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26076", "l": "H2O + UDP-alpha-D-glucuronate <=> D-glucuronate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77325", "l": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014610", "l": "Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015550", "l": "galacturonate transmembrane transporter activity", "d": ["Enables the transfer of galacturonate from one side of a membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191303", "l": "FDPS dimer transfers IPPP to GPP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61816", "l": "16,17-didehydropregnenolone + UDP-alpha-D-glucose = 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111742", "l": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76129", "l": "3',5'-cyclic AMP(in) + a dicarboxylate(out) => 3',5'-cyclic AMP(out) + a dicarboxylate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-428260", "l": "DEGS2 oxygenates dihydroceramide (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679031", "l": "Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31418", "l": "(2Z,6E)-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.202618949668349", "identifiers": [{"i": "GO:0019783", "l": "ubiquitin-like protein peptidase activity", "d": ["An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58055", "l": "(2-aminoethyl)phosphonate + acetyl-CoA <=> (2-acetamidoethyl)phosphonate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68180", "l": "a short-chain fatty acyl-CoA + H2O = a short-chain fatty acid + CoA + H(+)", "d": [], "t": []}, {"i": "EC:3.1.2.18", "l": "\"ADP-dependent short-chain-acyl-CoA hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670189", "l": "F8 variant does not bind the cell membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.21.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196857", "l": "PANK2 phosphorylates PanK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685605", "l": "SLAMF7 binds SLAMF7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5688276", "l": "SIRT4 transfers ADPRib to GLUD (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004328", "l": "formamidase activity", "d": ["Catalysis of the reaction: formamide + H2O = formate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5688786", "l": "ATXN3 binds RAD23 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62893", "l": "acetyl-CoA + 6 H(+) + 6 malonyl-CoA => 6 CO2 + 7 CoA + 2 H2O + nor-toralactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0140517", "l": "protein-RNA adaptor activity", "d": ["The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75719", "l": "CoA-disulfide + H2O = 4'-phosphopantetheinyl-CoA disulfide + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61062", "l": "a neolactoside nLc4Cer + H(+) + UDP => beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801109", "l": "CHM binds RGGT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656064", "l": "Activated FGFR1 binds FLRT1,2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75284", "l": "decanoate + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.25", "l": "\"(d)CMP kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31762", "l": "dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2 S-adenosyl-L-methionine <=> dTDP-alpha-D-desosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.21", "l": "\"Enterobacter ribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-879459", "l": "F-actin capping protein is a heterodimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5226999", "l": "ADD1:ADD3 binds DMTN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62339", "l": "AMP + ATP <=> adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21891", "l": "(1S,2S)-OPC-8 + NADP(+) <=> (9S,13S,15Z)-12-oxophyto-10-15-dienoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37838", "l": "aklavinone + H(+) + NADPH + O2 <=> epsilon-rhodomycinone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033992", "l": "1,5-anhydro-D-fructose dehydratase activity", "d": ["Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43020", "l": "L,L-cystathionine = 2-aminoprop-2-enoate + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27390", "l": "(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H2O => pyruvate + salicylaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801101", "l": "RABGGTA binds RABGGTB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9709098", "l": "DHFR dimer reduces FOLA to DHF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61675", "l": "ATP + H(+) + L-cysteine <=> diphosphate + L-cysteinyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198513", "l": "SLC7A4 exchanges G6P for Pi across the ER membrane  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21958", "l": "H(+) + UDP + vitexin 2''-O-beta-D-glucoside => UDP-alpha-D-glucose + vitexin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42089", "l": "all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20615", "l": "adenosine 3',5'-bisphosphate + H(+) + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine => 3'-phosphoadenylyl sulfate + a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11789", "l": "H2O + L-aspartate + NAD(+) => H(+) + NADH + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47375", "l": "a quinone + D-glucose <=> a quinol + D-glucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61405", "l": "ATP + N-(D-ribulosyl)-cadaverine => ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169901", "l": "Rap1-GTP complex binds BRAF complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-388814", "l": "Grb2 binds CD28 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199626", "l": "SLC19A2/3 transport extracellular THMN to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39233", "l": "(3R)-hydroxytriacontanoyl-CoA + NADP(+) => 3-oxo-triacontanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45734", "l": "(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate => D-ribulose 5-phosphate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-893583", "l": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46613", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990984", "l": "tRNA demethylase activity", "d": ["Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33677", "l": "H(+) + N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2 => H2O + N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-180038", "l": "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24902", "l": "3',3'-c-di-GMP + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.52", "l": "\"cyclic-guanylate-specific phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080101", "l": "phosphatidyl-N-dimethylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39971", "l": "1-aminocyclopropane-1-carboxylate = 2-aminobut-2-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5691006", "l": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110349", "l": "Displacement of UNG glycosylase by APEX1 at the AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76522", "l": "H2O + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] <=> (R)-lipoate + L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692755", "l": "CDK1 phosphorylates MAPK6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9631296", "l": "NR1H2,3 binds the FABP6 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68913", "l": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40505", "l": "N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine => N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19727", "l": "CO2 + UDP-beta-L-arabinopyranose => H(+) + UDP-alpha-D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75082", "l": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27473", "l": "ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.167", "l": "\"D-glycero-beta-D-manno-heptose-7-phosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043757", "l": "adenosylcobinamide-phosphate synthase activity", "d": ["Catalysis of the reactions: ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate, and ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9014420", "l": "RAC2 translocates to the phagocytic vesicle membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9824894", "l": "TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166817", "l": "Cleavage of C3 by C3 convertases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39423", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA = (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045130", "l": "keratan sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44855", "l": "(5Z)-tetradecenoyl-CoA + (R)-carnitine <=> CoA + O-(5Z)-tetradecenoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714959", "l": "TNF-alpha inhibitors bind to TNF(1-233) trimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25441", "l": "(2E,6E)-farnesyl diphosphate => delta-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000901", "l": "translation repressor activity, non-nucleic acid binding", "d": ["Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786650", "l": "DDHD1,2 hydrolyse PA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73589", "l": "5,6-dihydrouracil + H2O => beta-ureidopropionate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24290", "l": "(6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine => 5-formimidoyltetrahydrofolate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60934", "l": "17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850961", "l": "PREX2 binds PTEN and inhibits it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68174", "l": "CO2 + H2O + isodomoate A + succinate => 2-oxoglutarate + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678920", "l": "TLR processing at low pH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52693", "l": "3-phenyllactate + NADP(+) => 3-phenylpyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000831", "l": "inositol hexakisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32274", "l": "(2R,3S)-3-isopropylmalate + NAD(+) <=> 4-methyl-2-oxopentanoate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-183051", "l": "CBL ubiquitinates Sprouty (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.4.99.62", "l": "\"D-ribose pyranase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50040", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446694", "l": "IRAK4 phosphorylates IRAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371467", "l": "SIRT1 deacetylates HSF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625406", "l": "FOXO1,FOXO3 bind KLF4 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6801195", "l": "STEAP3 binds BNIP3L (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75880", "l": "Co(I)-[quaternary-amine-specific corrinoid protein] + H(+) + L-proline betaine => methyl-Co(III)-[quaternary-amine-specific corrinoid protein] + N-methyl-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31250", "l": "H(+) + prop-2-ynal + pyrroloquinoline quinol <=> prop-2-yn-1-ol + pyrroloquinoline quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2186741", "l": "SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74753", "l": "holo-[polyketide synthase] + prefumagillin => dodecapentaneoyl-[polyketide synthase] + fumagillol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68246", "l": "L-phenylalanine(out) + Na(+)(out) => L-phenylalanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3245898", "l": "TCN1 binds correnoids in the circulation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020255", "l": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668335", "l": "CHMP7 binds LEMD2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77109", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H(+) + octadecanoate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.78", "l": "\"granzyme A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192157", "l": "CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19395", "l": "(S)-2-amino-6-oxohexanoate + L-alanine => L-lysine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75178", "l": "dATP + NAD(+) <=> dADP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683630", "l": "Nucleoprotein translocates to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610760", "l": "GLI1 is degraded by the proteasome after ubiquitination by ITCH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53990", "l": "L-threonyl-[myosin light chain] + phosphate => H2O + O-phospho-L-threonyl-[myosin light chain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730900", "l": "Activation of TAK1 complex bound to pUb-TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140492", "l": "metal-dependent deubiquitinase activity", "d": ["An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158744", "l": "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193497", "l": "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678921", "l": "Full-length TLR3/7/8/9 binds to UNC93B1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433099", "l": "NaS2 co-transports sulphate and two sodium ions (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55547", "l": "L-lysyl-[citrate synthase] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46971", "l": "A + dihydroisopentenyldehydrorhodopin <=> AH2 + isopentenyldehydrorhodopin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008712", "l": "ADP-glyceromanno-heptose 6-epimerase activity", "d": ["Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627106", "l": "SMAC (DIABLO) forms dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58822", "l": "acetate + CO2 + Na(+)(out) => H(+) + malonate + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9674093", "l": "PDGFRs bind type I TKI (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1251922", "l": "PLCG1 phosphorylation by p-EGFR:p-ERBB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450971", "l": "NNT dimer transfers proton from NADPH to NAD+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-109701", "l": "PDPK1 binds PIP3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956365", "l": "ZBED1 (DREF) SUMOylates CHD3 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27758", "l": "(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.1.27", "l": "\"glycine cleavage system\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19414", "l": "ATP + L-phenylalanine + tRNA(Phe) => AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78620", "l": "L-lysyl-5'-AMP + tRNA(Lys) => AMP + H(+) + L-lysyl-tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202947", "l": "Caspase mediated cleavage of APC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806974", "l": "MET dimers autophosphorylate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56394", "l": "(3R)-hydroxybutanoate dimer + [(3R)-hydroxybutanoate](n-2) + H(+) => [(3R)-hydroxybutanoate](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030701", "l": "NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797568", "l": "NRXNs bind CASK:Protein 4.1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209240", "l": "Activated phosphorylated TAK1 kinase phosphorylates and activates IRD5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6810239", "l": "SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51737", "l": "L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65078", "l": "asperaculane D + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => dauca-4,7-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52057", "l": "12-hexadecanoyloxy-octadecanoate + H2O => 12-hydroxyoctadecanoate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870477", "l": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5362427", "l": "Hh-Np binds GPC5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25808", "l": "H2O + O2 + spermidine = 3-aminopropanal + H2O2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399999", "l": "AKT1 E17K mutant phosphorylates RSK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21389", "l": "H2O + L-2-aminohexano-6-lactam => L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73596", "l": "dCMP + H2O => dUMP + NH4+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59489", "l": "ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1678923", "l": "TLR folding by chaperones GP96 and CNPY3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39141", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA => (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32844", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycerol => a 1-acyl-sn-glycero-3-phosphocholine + a triacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-997237", "l": "SH2B proteins bind JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-400682", "l": "Active Rac1 interacts with Plexin-B1:Sema4D (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69616", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10935", "l": "ATP + L-aspartate + L-citrulline <=> 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112395", "l": "Abortive termination of elongation after arrest (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53046", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside)-ribonucleotide in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102427", "l": "allocryptopine 6-hydroxylase activity", "d": ["Catalysis of the reaction: allocryptopine + NADPH + O2 + H+ = 6-hydroxy-allocryptopine + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55871", "l": "(S)-lactate + O2 <=> H2O2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428664", "l": "SGPP1,2 dephosphorylate sphingoid-1-phosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58076", "l": "1-(11Z-eicosenoyl)-glycerol + H2O = (11Z)-eicosenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37863", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110317", "l": "Insertion of correct bases opposite the lesion by POLH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047705", "l": "bilirubin oxidase activity", "d": ["Catalysis of the reaction: 2 bilirubin + O2 = 2 biliverdin + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072590", "l": "N-acetyl-L-aspartate-L-glutamate ligase activity", "d": ["Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate."], "t": []}, {"i": "REACT:R-HSA-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37283", "l": "H2O + L-alanyl-L-histidine = L-alanine + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693551", "l": "Phosphorylation of BRCA1-A complex at multiple sites by ATM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16743", "l": "a 1,2-diacylglycerol + CoA => a 2-acylglycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46929", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42352", "l": "(R)-nicotine + A + H2O = (R)-6-hydroxynicotine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354073", "l": "Autophosphorylation of PTK2 at Y397 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3239019", "l": "Active p38 MAPK phosphorylates MAPKAPK5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3788724", "l": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804596", "l": "APAF1:CYCS binds APIP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11550", "l": "5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+) => 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173626", "l": "Activation of C1r (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649733", "l": "mature p21 RAS binds GDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730841", "l": "Phosphorylation and activation of VAV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031816", "l": "P2Y6 nucleotide receptor binding", "d": ["Binding to a P2Y6 nucleotide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50880", "l": "4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol = 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.45", "l": "\"teichoic acid glycerol-phosphate transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870449", "l": "TRIM33 monoubiquitinates SMAD4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14708", "l": "2 CoA + NADP(+) <=> CoA-disulfide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903878", "l": "11-deoxycorticosterone binding", "d": ["Binding to 11-deoxycorticosterone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9757139", "l": "ABCB1,ABCC2 transport ATVs from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53167", "l": "H2O + N,1-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44354", "l": "ADP + dapdiamide C + H(+) + phosphate => ATP + L-leucine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75862", "l": "Fall Back to Closed Pre-initiation Complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186786", "l": "Autophosphorylation of PDGF beta receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679044", "l": "FKBP1A binds sirolimus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38984", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O => 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592243", "l": "Expression of POLRMT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13759", "l": "(Z)-desulfoglucotropeolin + UDP => (Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54649", "l": "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9757256", "l": "MCM3 binds MCM5 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008270", "l": "NCOA1 binds ESR1:estrogen:TGFA gene (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9641127", "l": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139905", "l": "Translocation of activated BAD protein to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694527", "l": "Loss of SAR1B GTPase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25185", "l": "1,2-dichloroethane + H2O = 2-chloroethanol + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38629", "l": "1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA => 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8956649", "l": "The complex of RUNX1 and YAP1 binds the ITCH gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876188", "l": "DENND4s exchange GTP for GDP on RAB10 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032132", "l": "O6-alkylguanine-DNA binding", "d": ["Binding to an O6-alkylguanine adduct in DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49412", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP-beta-L-colitose = alpha-L-colitosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.341", "l": "\"alpha-1,2-colitosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12183", "l": "anthranilate + S-adenosyl-L-methionine <=> H(+) + N-methylanthranilate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800035", "l": "IGFBP3 binds TMEM219 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17117", "l": "ATP + L-glutamate + methylamine = ADP + H(+) + N(5)-methyl-L-glutamine + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.12", "l": "\"glutamate--methylamine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43981", "l": "H(+) + hexadecanoate + NADPH + O2 => 15-hydroxyhexadecanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17093", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}, {"i": "EC:4.6.1.13", "l": "\"phosphatidylinositol diacylglycerol-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2889070", "l": "SLC9B2 exchanges Na+ for H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71132", "l": "H(+)(in) + L-asparagine(out) + Na(+)(out) => H(+)(out) + L-asparagine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008928", "l": "IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57548", "l": "(S)-beta-macrocarpene + O2 + reduced [NADPH--hemoprotein reductase] = [(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)-cyclohex-1-en-1-yl]methanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612501", "l": "SGK phosphorylates CREB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952062", "l": "CCND1 recruits HDAC4 to RUNX3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796053", "l": "PRKCI phosphorylates NFE2L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49555", "l": "H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] <=> H(+) + L-lysyl-[protein] + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799097", "l": "ATM phosphorylates ZNF420 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870352", "l": "SLC36A4 transports L-Trp from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13795", "l": "2-methylene-3-methylsuccinate => 2-methyleneglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56887", "l": "adenosine(32) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60342", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(79)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835454", "l": "DNAJC3 binds PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48335", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31110", "l": "3-phenylpyruvate + O2 <=> (2-hydroxyphenyl)acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68054", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+) => a ribonucleotidyl-ribonucleotide-RNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13577", "l": "a wax ester + H2O = a long chain fatty alcohol + a long-chain fatty acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.50", "l": "\"wax-ester hydrolase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34458", "l": "all-trans-beta-carotene <=> 9-cis-beta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14394", "l": "N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine => 3 H(+) + N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74018", "l": "4-hydroxybenzoate + H(+) + phosphate <=> CO2 + H2O + phenyl phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090439", "l": "tetraketide alpha-pyrone synthase activity", "d": ["Catalyzes the reaction: a hydroxyacyl-CoA + 3 malonyl-CoA + 2 H+ = a hydroxylated tetraketide alpha-pyrone + 3 CO2 + 4 coenzyme A ."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.64", "l": "\"inosine diphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9661625", "l": "FVIII is secreted (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41541", "l": "8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730899", "l": "Oligomerization of BCL10 and MALT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381537", "l": "PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42051", "l": "3-hydroxybutanoyl-CoA + NAD(+) <=> acetoacetyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9853372", "l": "FIRRM binds PPP1CC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40300", "l": "6-deoxyerythronolide B + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => erythronolide B + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52284", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-398040", "l": "Gbeta:gamma activation of PLC beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166245", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70277", "l": "D-galactose + sucrose => H2O + raffinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605259", "l": "Active FLT3 binds FYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693347", "l": "CRYM reduces P2C to PPCA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879674", "l": "CD97 binds CD55 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9829164", "l": "F subunits form trimers at plasma membrane rafts (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71606", "l": "2-oxoglutarate(out) + oxaloacetate(in) <=> 2-oxoglutarate(in) + oxaloacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391867", "l": "Fyn binds NCAM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17550", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine => 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62196", "l": "2 Fe(III)-[cytochrome c] + propan-2-ol = acetone + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6793666", "l": "MDM2 translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654408", "l": "Activated FGFR3 phosphorylates FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70692", "l": "ornithine => putrescine + CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28129", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose <=> alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16120", "l": "acetoacetate + ATP + CoA <=> acetoacetyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.942687253280909", "identifiers": [{"i": "GO:0016846", "l": "carbon-sulfur lyase activity", "d": ["Catalysis of the elimination of hydrogen sulfide or substituted H2S."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61079", "l": "(-)-minovincinine + acetyl-CoA <=> (-)-echitovenine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804527", "l": "INTL1 binds bacterial glycans (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41685", "l": "1-O-(9Z-octadecenyl)-sn-glycero-3-phosphocholine + H2O => 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19877", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.67", "l": "\"1-phosphatidylinositol 4-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110307", "l": "REV1 binds AP-dsDNA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78037", "l": "a 1,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140295", "l": "pathogen-derived receptor ligand activity", "d": ["The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102714", "l": "gibberellin A12,oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 = gibberellin A14 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114683", "l": "Phosphorylation of Platelet Sec-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-169895", "l": "Crk's SH3 domain engages C3G (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202437", "l": "Phosphorylation of CARMA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047550", "l": "2-oxoadipate reductase activity", "d": ["Catalysis of the reaction: 2-hydroxyadipate + NAD+ = 2-oxoadipate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39478", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA <=> (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63503", "l": "H(+) + NADPH + S-nitrosoglutathione <=> NADP(+) + sulfinamide glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42872", "l": "N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71020", "l": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70132", "l": "3-dehydro-6alpha-hydroxy-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6-dehydro-28-norteasterone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35846", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50827", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 <=> 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17118", "l": "ATP + L-glutamate + methylamine => ADP + H(+) + N(5)-methyl-L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63352", "l": "2 H(+) + O2 + octadecanoyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] = (9Z)-octadecenoyl-CoA + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57497", "l": "2-methylcitrate => 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75135", "l": "NADP(+) + neopine = H(+) + NADPH + neopinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917696", "l": "Cargo Sequestration (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045482", "l": "trichodiene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + trichodiene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.119", "l": "\"glucose 1-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31701", "l": "3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin] + pentalen-13-al => 4 H(+) + 2 O2 + pentalenene + 4 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9686930", "l": "RIPK3 is cleaved by CASP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36245", "l": "(E)-coumaryl acetate + NADPH => (E)-anol + acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388831", "l": "Phosphorylation of CD28 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35989", "l": "1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193656", "l": "p75NTR interacts with RIP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9755505", "l": "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046537", "l": "2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity", "d": ["Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8866941", "l": "MID1IP1 binds THRSP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2426450", "l": "Laminins:Nidogens binds collagen type IV networks (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61884", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 1-O-methyl-9-hydroperoxy-20-hydroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15376", "l": "columbamine + S-adenosyl-L-methionine <=> H(+) + palmatine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33570", "l": "A + ethanol <=> acetaldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77317", "l": "5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine => glyoxylate + N(omega),N('omega)-dimethyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24417", "l": "2,4'-dihydroxyacetophenone + O2 => 4-hydroxybenzoate + formate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58285", "l": "5,6-dihydrothymine + NADP(+) => H(+) + NADPH + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71572", "l": "5-O-(L-seryl)-dTMP in DNA + H(+) => 5-aminoethoxy-methyl-dUMP in DNA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73549", "l": "GTP(in) + UTP(out) => GTP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389463", "l": "Proteinase-activated receptors can bind thrombin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18423", "l": "chloramphenicol 3-acetate + CoA => acetyl-CoA + chloramphenicol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59542", "l": "butanoyl-CoA + CO2 => (2R)-ethylmalonyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58858", "l": "(6E)-8-oxogeraniol + H(+) + NADH => (6E)-8-hydroxygeraniol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39373", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+) => 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51416", "l": "a (2S,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9754974", "l": "ADK phosphorylates RBV (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990300", "l": "cellulosome binding", "d": ["Binding to a cellulosome, an extracellular multi-enzyme complex containing several enzymes aligned on a non-catalytic scaffolding that functions to hydrolyze plant cell wall polysaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4616015", "l": "SUMOylation of HDAC2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61956", "l": "1-O-octadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674019", "l": "BRAP binds KSR1:MARK3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604368", "l": "Autocatalytic activation of bound proMMP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12570", "l": "4-nitrocatechol + H2O + NAD(+) => 4-nitrophenol + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64102", "l": "H(+) + S-adenosyl-L-homocysteine + TAN-1612 => 2-acetyl-3,4a,8,10,11,12a-hexahydroxy-1,4,4a,5,12,12a-hexahydrotetracene-1,12-dione + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37743", "l": "dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2", "d": [], "t": []}, {"i": "EC:2.5.1.129", "l": "\"flavin prenyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.3", "l": "\"ficain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903135", "l": "cupric ion binding", "d": ["Binding to a cupric ion, copper(2+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202437", "l": "Phosphorylation of CARMA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52853", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] => 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56807", "l": "2 cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] <=> 2 cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14605", "l": "D-glucose 6-phosphate + GDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.36", "l": "\"alpha,alpha-trehalose-phosphate synthase (GDP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54724", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875817", "l": "MET phosphorylates STAT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199566", "l": "KIR3DL1 interacting with HLA Bw4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754916", "l": "NT5C2 tetramer phosphorylates RBV (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76149", "l": "2 H(+) + S-adenosyl-L-homocysteine + vobasine => perivine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1433542", "l": "Phosphorylation and activation of VAV1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017017", "l": "MAP kinase tyrosine/serine/threonine phosphatase activity", "d": ["Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20963", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19167", "l": "1,2-diacyl-3-O-[alpha-D-glucosyl-(1-> 2)-alpha-D-glucosyl]-sn-glycerol + H(+) + UDP => a 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187325", "l": "PARP1 ADP-ribosylates SMAD3 and SMAD4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475028", "l": "Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21478", "l": "[(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP => [(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018774", "l": "RHOBTB1 binds GTP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9690877", "l": "Expression of DMRT1 in testis differentiation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58854", "l": "(6E)-8-oxogeranial + H(+) + NADH => (6E)-8-oxogeraniol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201669", "l": "Beta-catenin translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.289590649673869", "identifiers": [{"i": "GO:0022839", "l": "monoatomic ion-gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19997", "l": "H2O + phosphoenolpyruvate = phosphate + pyruvate", "d": [], "t": []}, {"i": "EC:3.1.3.60", "l": "\"phosphoenolpyruvate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65183", "l": "AH2 + O2 + protoaustinoid B <=> A + H2O + preaustinoid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640861", "l": "RNF146 ubiquitinates ADP-ribosylated AXIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.125", "l": "\"sucrose--1,6-alpha-glucan 3(6)-alpha-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60682", "l": "(+)-artemisinate + 2 H(+) + NADPH => (+)-artemisinic aldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20635", "l": "a lyso-ornithine lipid + H(+) + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42782", "l": "4 H(+) + N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine => adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47796", "l": "an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H(+) + NH4(+) + 2 reduced [azurin]", "d": [], "t": []}, {"i": "EC:1.4.9.2", "l": "\"aralkylamine dehydrogenase (azurin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2309773", "l": "PGG2 is reduced to PGH2 by PTGS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5631885", "l": "PRDX1 overoxidizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31505", "l": "4,6-Me(COOH)C-beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphate => beta-D-Man-(1->4)-beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0045569", "l": "TRAIL binding", "d": ["Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3234094", "l": "SUMOylation of TFAP2C with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018619", "l": "benzene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: benzene + H+ + NADH + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551571", "l": "WNT5A binds ROR2 and VANGL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022052", "l": "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18957", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.53", "l": "\"(R)-limonene 6-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9005980", "l": "IL21 binds IL21R:JAK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-877281", "l": "PIAS1 binds p-STAT1 dimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77726", "l": "a neolactoside nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose <=> a neolactoside V(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34100", "l": "carboxynorspermidine + H(+) => CO2 + norspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9824995", "l": "GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858270", "l": "HILPDA binds lipid droplets (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018499", "l": "ESR1:ESTG and EP300 are recruited to TFF3 promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18284", "l": "NAD(+) + succinate <=> fumarate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73835", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + sn-3-(O-farnesylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.156", "l": "\"geranylfarnesylglycerol-phosphate geranylfarnesyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6799495", "l": "GLYCTK phosphorylates DGA to 3PDGA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77701", "l": "a ganglioside GT1balpha  (d18:1(4E)) + CMP + H(+) => a ganglioside GD1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20398", "l": "L-cysteine + O-succinyl-L-homoserine => H(+) + L,L-cystathionine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18248", "l": "3'-dephospho-CoA + ATP <=> ADP + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32345", "l": "(+)-thujan-3-one + H(+) + NADH => (+)-thujan-3-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-163670", "l": "Nuclear transport of pChREBP (Thr 666) protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26153", "l": "(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil => 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53404", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1253343", "l": "WWOX binds ERBB4s80 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050418", "l": "hydroxylamine reductase activity", "d": ["Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676174", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41429", "l": "L-tyrosine + S-adenosyl-L-methionine => 3-methyl-L-tyrosine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192097", "l": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-421833", "l": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205673", "l": "p62 binds ubiquitinated mitochondrial substrates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034861", "l": "benzothiazole-2-sulfonate hydrolase activity", "d": ["Catalysis of the reaction: benzothiazole-2-sulfonate + H2O = 2-hydroxybenzothiazole + HSO3-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1564120", "l": "Collagen type VII degradation by MMP1,2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30647", "l": "1D-myo-inositol 3-phosphate + CTP + H(+) = CDP-1L-myo-inositol + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.74", "l": "\"1L-myo-inositol 1-phosphate cytidylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40528", "l": "2 a ubiquinol + 4 H(+)(in) + O2(in) => 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17274", "l": "(4-hydroxyphenyl)acetaldehyde + H2O + NAD(+) => 4-hydroxyphenylacetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73265", "l": "apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine => genkwanin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952382", "l": "MDM2 polyubiquitinates RUNX3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40263", "l": "(3R)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13245", "l": "D-threo-isocitrate = glyoxylate + succinate", "d": [], "t": []}, {"i": "EC:4.1.3.1", "l": "\"isocitrate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578965", "l": "TNRC6A binds AGO2:miRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76889", "l": "5-hydroxypentan-2-one + H(+) + NADH + NH4(+) => 5-hydroxypentan-2-amine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67919", "l": "adenosine 5'-phosphoramidate + H2O <=> AMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73539", "l": "dCTP(out) + UTP(in) = dCTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.325", "l": "\"sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61929", "l": "(R)-miconazole(in) + ATP + H2O => (R)-miconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68154", "l": "a triacylglycerol + CoA => a 1,3-diacylglycerol + a fatty acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605700", "l": "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64443", "l": "glycylglycyl-L-proline(out) + H(+)(out) <=> glycylglycyl-L-proline(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46615", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol <=> (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358790", "l": "RNF41 ubiquitinates ERBB3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052836", "l": "inositol 5-diphosphate pentakisphosphate 5-kinase activity", "d": ["Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47065", "l": "4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798299", "l": "TP53 stimulates E2F7 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450387", "l": "HuR binds the CRM1 nuclear export machinery (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050339", "l": "TTPase activity", "d": ["Catalysis of the reaction: dTTP + H2O = dTDP + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046904", "l": "calcium oxalate binding", "d": ["Binding to calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2545203", "l": "Deacetylation of cleaved cohesin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840488", "l": "PSAP(195-273) forms a dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004054", "l": "arginine kinase activity", "d": ["Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71334", "l": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32887", "l": "all-trans-beta-carotene + O2 = 2 all-trans-retinal", "d": [], "t": []}, {"i": "EC:1.13.11.63", "l": "\"beta-carotene 15,15'-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70724", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690196", "l": "USP8 deubiquitinates RNF128 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20417", "l": "coelenterazine + O2 = CO2 + coelenteramide + hnu", "d": [], "t": []}, {"i": "EC:1.13.12.13", "l": "\"Oplophorus-luciferin 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57496", "l": "2-methylcitrate = 2-methyl-cis-aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901707", "l": "leptomycin B binding", "d": ["Binding to leptomycin B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1028812", "l": "Expression of interferon-beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75692", "l": "2'-deoxyadenosine(in) => 2'-deoxyadenosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29127", "l": "a menaquinol + nitrate = a menaquinone + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49618", "l": "2-hydroxy-2-methylpropanoate + 2 H(+) + NADH => 2-hydroxy-2-methylpropanal + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1474210", "l": "Collagen type III degradation by MMP14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028626", "l": "Phosphorylated MOB1A proteins associate with LATS proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9667619", "l": "AVPR1A,B,2 bind atosiban (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66502", "l": "alpha-D-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-cis-undecaprenol + GDP + H(+) => GDP-alpha-D-rhamnose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834003", "l": "L protein acts as a cap 2'-O-methyltransferase to modify RSV mRNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75856", "l": "Abortive Initiation Before Second Transition (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0008079", "l": "translation termination factor activity", "d": ["Functions in the termination of translation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674816", "l": "p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173545", "l": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73989", "l": "diphosphate + discoidol => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1980125", "l": "ITCH binds DTX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446214", "l": "Synthesis of dolichyl-phosphate-glucose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936942", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9842649", "l": "Active LTK receptor binds PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197564", "l": "NOTCH2 stimulates transcription of HES5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37962", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate <=> (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9755304", "l": "MUL1 ubiquitinates UBXN7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47786", "l": "5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76367", "l": "n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(out) = n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58227", "l": "L-glutamyl-[protein] + NAD(+) <=> 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73758", "l": "2 H(+)(out) + histamine(in) <=> 2 H(+)(in) + histamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67340", "l": "malonyl-CoA + quercetin 3-O-beta-D-glucoside = CoA + quercetin 3-O-(6-O-malonyl-beta-D-glucoside)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49020", "l": "2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807144", "l": "HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61238", "l": "4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+) => H2O + L-methionine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77090", "l": "Methylation of GMP-cap by RNA Methyltransferase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5674385", "l": "p-T,Y MAPKs dimerize (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430183", "l": "NCK binds PAK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.36", "l": "\"trihydroxypterocarpan dimethylallyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851890", "l": "MET phosphorylates SHC1-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250195", "l": "SHC1 phosphorylation by ERBB2 heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12485", "l": "a ribonucleoside 5'-phosphate + H2O => a ribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11598", "l": "CO2 + UMP => H(+) + orotidine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69960", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9839368", "l": "TGFBR3(1-783) binds to TGFB1,TGFB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004957", "l": "prostaglandin E receptor activity", "d": ["Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-870538", "l": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14374", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6814682", "l": "Fusion of early-endosome derived vesicles at the TGN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8878581", "l": "TYRP1 oxidises DHICA to IQCA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160141", "l": "23S rRNA pseudouridine(955/2504/2580) synthase activity", "d": ["Catalysis of the reaction: uridine(955/2504/2580) in 23S rRNA = pseudouridine(955/2504/2580) in 23S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180710", "l": "Rev:importin beta:B23 recruited to the nuclear pore (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849463", "l": "PTK6 phosphorylates SFPQ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20181", "l": "alpha-D-mannose derivative + UDP-alpha-D-glucose = 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H(+) + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.19", "l": "\"UDP-glucose--glycoprotein glucose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64197", "l": "an N-(fatty acyl)-L-lysine + H2O => a fatty acid + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610725", "l": "TULP3 is required for GPR161 localization in the cilium (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64704", "l": "diphenylmethanol + NAD(+) = benzophenone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73007", "l": "D-arabinose 5-phosphate = D-glyceraldehyde 3-phosphate + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67560", "l": "3'-phosphoadenylyl sulfate + taurocholate = adenosine 3',5'-bisphosphate + H(+) + taurocholate 7-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375790", "l": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163096", "l": "Recruitment of Telomerase RNP to the Telomeric Chromosome End (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8865605", "l": "BRWD1 binds SMARCA4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54208", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54211", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 <=> 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27602", "l": "(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate = di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8870461", "l": "RABGGTA and RABGGTB bind (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165195", "l": "GTP loading by Rheb (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-171141", "l": "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11011", "l": "a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O <=> a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73574", "l": "(E,E)-piperate + ATP + CoA <=> (E,E)-piperoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791157", "l": "Expression of DNAJC3 (p58IPK) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46318", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H(+) => GDP-N,N'-diacetylbacillosamine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30775", "l": "H2O + O2 + pyridoxamine = H2O2 + NH4(+) + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72262", "l": "L-dopa + S-adenosyl-L-methionine <=> 3-O-methyl-L-dopa + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32596", "l": "7-isopropyl-4-methyloxepan-2-one + H2O => 6-hydroxy-3,7-dimethyloctanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39097", "l": "3-oxodecanedioyl-CoA + H(+) + NADH => (3S)-hydroxydecanedioyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429694", "l": "CERT1-2 complex dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045519", "l": "interleukin-23 receptor binding", "d": ["Binding to an interleukin-23 receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.39", "l": "\"adenain\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16389", "l": "4-hydroxybenzoate + 2 H(+) + NADH + O2 = CO2 + H2O + hydroquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018453", "l": "2-hydroxytetrahydrofuran dehydrogenase activity", "d": ["Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19556", "l": "H2O + L-tryptophan <=> indole + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40281", "l": "CoA + O-dodecanoyl-R-carnitine => (R)-carnitine + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25094", "l": "ATP + dCMP = ADP + dCDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.46", "l": "\"glycerophosphodiester phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981621", "l": "Neuroglobin:oxygen dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29457", "l": "D-serine(out) => D-serine(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429732", "l": "Multiphospho-CERT1-2 binds PPM1L, VAPA/B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10845", "l": "oxaloacetate + pyridoxamine => L-aspartate + pyridoxal", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50527", "l": "acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.28", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61056", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030395", "l": "lactose binding", "d": ["Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23998", "l": "a ribonucleoside 5'-phosphate + diphosphate + H(+) => a ribonucleoside 5'-triphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5683425", "l": "ATM phosphorylates TP53BP1 at DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194023", "l": "HSD11B2,HSD11B1 dimer oxidise CORT to COR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22461", "l": "a 2,3-saturated acyl-CoA + NADP(+) => a 2,3-dehydroacyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050147", "l": "nucleoside ribosyltransferase activity", "d": ["Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8876615", "l": "RAB13 GEFs exchange GTP for GDP on RAB13 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044105", "l": "L-xylulose reductase (NADH) activity", "d": ["Catalysis of the reaction: xylitol + NAD+ = L-xylulose + NADH + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53196", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443402", "l": "GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69260", "l": "(Z)-(2R)-2-hydroxy-3-butenyl-N-(sulfonatooxy)methanimidothioate = (3R)-3-hydroxy-3-(thiiran-2-yl)propanenitrile + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5577213", "l": "LTCC multimer transports Ca2+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781922", "l": "USP13 binds UFD1L:SKP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51598", "l": "4-methylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + p-xylene + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40509", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78578", "l": "(3S)-hydroxydocosanoyl-CoA <=> (2E)-docosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800380", "l": "PTPRD binds IL1RAP-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102596", "l": "cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity", "d": ["Catalysis of the reaction: ent-sandaracopimara-8(14),15-diene + NADPH + H+ + O2 = ent-sandaracopimaradien-3beta-ol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237140", "l": "Dehydration of methylthio-ribulose-P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4656914", "l": "SUMOylation of NFKBIA with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28058", "l": "L-lyxopyranose = L-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23230", "l": "H2O + N(6)-hydroxy-L-lysine + NADP(+) => L-lysine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10089", "l": "sucrose + UDP-alpha-D-galactose => 6(F)-alpha-D-galactosylsucrose + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65896", "l": "glyoxylate + L-kynurenine = glycine + H2O + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75823", "l": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938887", "l": "PML binds RUNX1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9829183", "l": "F1 binds to F2 forming the F subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56598", "l": "(1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O => (1S,4S)-bornane-2,5-dione + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76423", "l": "(8S)-annullatin E + dimethylallyl diphosphate = (8S)-annullatin J + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444419", "l": "RhBG mediates ammonium effflux out of kidney collecting duct cells (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-469659", "l": "SRD5A1 dehydrogenates TEST to DHTEST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030742", "l": "GTP-dependent protein binding", "d": ["Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48909", "l": "L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61507", "l": "pelargonidin + UDP-alpha-D-glucose <=> pelargonidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399930", "l": "Activation of PAK by Rac1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372855", "l": "malate + NAD+ <=> oxaloacetate + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234169", "l": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49128", "l": "AH2 + N-acetyl-demethyl-L-phosphinothricin + 2 S-adenosyl-L-methionine = 5'-deoxyadenosine + A + 2 H(+) + L-methionine + N-acetyl-L-phosphinothricin + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.326", "l": "\"N-acetyl-demethylphosphinothricin P-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45834", "l": "3-oxodecanoyl-CoA + H(+) + NADH => (3R)-3-hydroxydecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.514861039037328", "identifiers": [{"i": "GO:0016891", "l": "RNA endonuclease activity, producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68759", "l": "4 (R)-3-phenyllactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine <=> 8 AMP + 8 diphosphate + 8 H(+) + PF1022B + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3785684", "l": "Fibronectin degradation by CTSG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47474", "l": "(3E)-tetradecenoyl-CoA + NADP(+) => (2E,4E)-tetradecadienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22018", "l": "arsenite + glutathionyl-S-S-[glutaredoxin] + H2O => [glutaredoxin]-dithiol + arsenate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380930", "l": "Phosphorylated AMPK binds AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450054", "l": "Interleukin-2 receptor alpha binds interleukin-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21452", "l": "a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}, {"i": "EC:1.14.17.3", "l": "\"peptidylglycine monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-376851", "l": "SLC25A11 exchanges 2-OG and MAL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854209", "l": "TBC1D10A binds JFC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72631", "l": "Formation of the cap-binding eIF4F complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32469", "l": "glycine betaine + 2 H(+) + 2 S-adenosyl-L-homocysteine => 2 S-adenosyl-L-methionine + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52492", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64329", "l": "(7Z)-octadecenoyl-CoA + cholesterol => cholesteryl (7Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399712", "l": "Activation of Ca permeable AMPA receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44323", "l": "1-decanoylglycerol + H2O <=> decanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6789031", "l": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54836", "l": "H(+) + heptan-2-one + NADPH + O2 = H2O + NADP(+) + pentyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61902", "l": "A + betaenone B => AH2 + betaenone C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938034", "l": "NR4A3 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34263", "l": "dimethylallyl diphosphate + fumigaclavine A = diphosphate + fumigaclavine C", "d": [], "t": []}, {"i": "EC:2.5.1.100", "l": "\"fumigaclavine A dimethylallyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37866", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA <=> 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218805", "l": "PKC autophosphorylates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18446", "l": "H2O + IMP => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20038", "l": "D-sorbitol 6-phosphate + NADP(+) => aldehydo-D-glucose 6-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62821", "l": "1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19826", "l": "(2E,6E)-farnesyl diphosphate => (+)-aristolochene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76153", "l": "18-hydroxy-11-deoxycorticosterone + H2O + 2 oxidized [adrenodoxin] => 21-hydroxyprogesterone + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.86", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937613", "l": "CRHBP binds CRH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22947", "l": "3beta-hydroxy-5beta-pregnane-20-one + NADP(+) <=> 5beta-pregnan-3,20-dione + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2731002", "l": "CLCN3 exchanges Cl- for H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51531", "l": "H(+) + vanillate <=> CO2 + guaiacol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28504", "l": "H(+) + NADH + S-formylmycothiol => NAD(+) + S-(hydroxymethyl)mycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662608", "l": "MT2A binds cadmium (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950681", "l": "Expression of Lamin-B1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655233", "l": "Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9007901", "l": "IL1F10 binds IL1RL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34036", "l": "O2 + paromamine => 6'-oxoparomamine + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362518", "l": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45095", "l": "H2O + N-octanoylsphing-4-enine <=> octanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48685", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O => [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40289", "l": "AMP + decanedioyl-CoA + diphosphate => ATP + CoA + decanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047547", "l": "2-methylcitrate dehydratase activity", "d": ["Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77563", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoylglycerol = 1-(9Z-octadecenoyl)-3-hexadecanoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983335", "l": "IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0032137", "l": "guanine/thymine mispair binding", "d": ["Binding to a double-stranded DNA region containing a G/T mispair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785361", "l": "Monoubiquitination of FANCD2:FANCI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086078", "l": "gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling", "d": ["A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55658", "l": "a carotenoid chi-end derivative + 2 AH2 => 2 A + a carotenoid beta-end derivative", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46779", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-451311", "l": "Activation of Ca-permeable Kainate receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.-", "l": "\"Peptidyl peptide hydrolases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75371", "l": "guanosine(in) = guanosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68406", "l": "2-oxoheptanedioate + CO2 + NADH => (2R,3S)-iso(homo)2citrate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66079", "l": "2-oxopentanoate + L-kynurenine <=> H2O + kynurenate + L-2-aminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49728", "l": "2 H(+) + NADPH + 2 O2 + protoviolaceinate = CO2 + 2 H2O + NADP(+) + violacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141156", "l": "TRAIL-mediated dimerization of procaspase-8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25177", "l": "4-methyl-2-oxopentanoate + CoA + NAD(+) = 3-methylbutanoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9709360", "l": "H2O2 reduces MetHb (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5654989", "l": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1963581", "l": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53487", "l": "androst-4-ene-3,11,17-trione + H(+) + NADPH <=> 17beta-hydroxyandrost-4-ene-3,11-dione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44545", "l": "a fatty acid(out) + ATP + H2O => a fatty acid(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12554", "l": "(E)-pinosylvin + 4 CO2 + 4 CoA => (E)-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690043", "l": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57318", "l": "ADP + cytidine 3'-phospho-5'-diphosphoramidate + H(+) => ATP + cytidine 5'-diphosphoramidate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874079", "l": "PTK2 binds activated MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24273", "l": "H(+) + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 => H2O + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857583", "l": "LINC01139 promotes phosphorylation of HIF1A by PTK6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12630", "l": "2-oxoglutarate + L-hyoscyamine + O2 => (6S)-6-hydroxyhyoscyamine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46545", "l": "an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8942099", "l": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13359", "l": "3-oxopropanoate + H(+) + NADH => 3-hydroxypropanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71425", "l": "3,3',5-triiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out) => 3,3',5-triiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419003", "l": "Interaction of Nectins with Afadin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45698", "l": "N-(acetyl)-sphing-4-enine-1-phosphate(out) => N-(acetyl)-sphing-4-enine-1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13873", "l": "(+)-copalyl diphosphate = abieta-7,13-diene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.18", "l": "\"abieta-7,13-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77245", "l": "CO2 + heptadecane => H(+) + hnu + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070404", "l": "NADH binding", "d": ["Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176669", "l": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654628", "l": "Activated FGFR3 phosphorylates FRS3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-156673", "l": "Regulation of KIF23 (MKLP1) by phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77824", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-alanine + O2 => (2S)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36786", "l": "L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16959", "l": "GMP + H(+) => 3',5'-cyclic GMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264758", "l": "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63683", "l": "(7R,8S)-7,8-diammoniononanoate + CO2 <=> (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48221", "l": "H(+) + oxidized [electron-transfer flavoprotein] + tricosanoyl-CoA => (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006490", "l": "MECP2 binds the GRIN2A gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9699578", "l": "Active FLT3 phosphorylates CDKN1B (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-72722", "l": "eIF2 activation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54569", "l": "a uridine in rRNA => a pseudouridine in rRNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693608", "l": "Initial resection of double-strand break ends (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161794", "l": "Arachidonic acid is converted to HXA3/B3 by ALOX12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5674140", "l": "PAQR3 binds inactive RAFs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56883", "l": "a 3beta-hydroxy-Delta(5)-steroid + NADP(+) <=> a 3-oxo-Delta(5)-steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37011", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855111", "l": "VLDLR binds PCSK9 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786500", "l": "ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48405", "l": "apo-[aryl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[aryl-carrier protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10577", "l": "CTP + H(+) + N-methylethanolamine phosphate => CDP-N-methylethanolamine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20992", "l": "16-hydroxytabersonine + S-adenosyl-L-methionine = 16-methoxytabersonine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.94", "l": "\"tabersonine 16-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43883", "l": "(25S)-3beta-hydroxy-5-cholestenoate + ATP + CoA <=> (25S)-3beta-hydroxy-5-cholestenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33208", "l": "ATP + H(+) + L-glutamate + NADPH => ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627775", "l": "Autophosphorylation of PAK1,2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21533", "l": "ATP + glutathione + glutathionylspermidine => ADP + H(+) + phosphate + trypanothione", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950342", "l": "EBI3:CANX binds IL27 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20913", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => diphosphate + taxa-4,11-diene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2426259", "l": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797554", "l": "ABP1 binds SHANK proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45614", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine => H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48477", "l": "a ganglioside GT1a (d18:1(4E)) + H2O => a ganglioside GD1a (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9710254", "l": "GSDME oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004525", "l": "ribonuclease III activity", "d": ["Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984012", "l": "JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8959573", "l": "Phosphorylated FUNDC1 links damaged mitochondria to LC3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2990840", "l": "SENP1,2,5 proteolytically process SUMO1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.15", "l": "\"guanosine phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086056", "l": "voltage-gated calcium channel activity involved in AV node cell action potential", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450257", "l": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55149", "l": "a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP(+) => a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54399", "l": "1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218811", "l": "DOCK180:ELMO binds CRK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-198669", "l": "p38MAPK phosphorylates MSK1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036310", "l": "ATP-dependent DNA/DNA annealing activity", "d": ["An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983519", "l": "IL35 binds IL12RB2:IL12RB2 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32855", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acylglycerol = a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008763", "l": "UDP-N-acetylmuramate-L-alanine ligase activity", "d": ["Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034056", "l": "estrogen response element binding", "d": ["Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661723", "l": "SLCO2B1-3 transports BIL  from extracellular region (blood) to cytosol (hepatocyte) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2060328", "l": "Phosphorylation of WWTR1 (TAZ) by LATS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043732", "l": "6-hydroxynicotinate dehydrogenase activity", "d": ["Catalysis of the reaction: 6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624956", "l": "PDE6D binds INPP5E (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785732", "l": "DNA nucleases bind monoubiquitinated ID2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66217", "l": "asc-C7-CoA + O2 => asc-DeltaC7-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9681763", "l": "IL1R1 binds IL1R1 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30764", "l": "H2O + L-valine + NAD(+) => 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31491", "l": "soyasaponin III + UDP-beta-L-rhamnose = H(+) + soyasaponin I + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.273", "l": "\"soyasaponin III rhamnosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174202", "l": "Degradation of multiubiquitinated Securin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77711", "l": "Fe(III)-heme b-[protein] + H2O + nitric oxide = Fe(II)-heme b-[protein] + 2 H(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11850", "l": "[thioredoxin]-dithiol + glycine betaine + H(+) + phosphate => [thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73794", "l": "dimethylallyl diphosphate + neoechinulin A <=> diphosphate + variecolorin G", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683719", "l": "Spike protein forms a homotrimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49357", "l": "2'-hydroxy-2-oxospirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 2',2'-dihydroxy-2-oxospirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9712201", "l": "GNAL exchanges GDP for GTP in odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34638", "l": "1-deoxy-11-oxopentalenate + H(+) + NADPH + O2 <=> H2O + NADP(+) + pentalenolactone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52436", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649854", "l": "Recruitment of POLB to oxidatively damaged AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62911", "l": "nor-toralactone + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + toralactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53832", "l": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5622134", "l": "CRABP1 binds atRA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10038", "l": "H2O2 + vanillin => 4-hydroxy-3-methoxy-benzenemethanol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351876", "l": "Caspase-mediated cleavage of occludin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9845516", "l": "B3GALT4 transfers Gal to gangliosides (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990518", "l": "single-stranded 3'-5' DNA helicase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848339", "l": "PNPLA5 hydrolyzes TAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58025", "l": "oleanolate + UDP-alpha-D-glucose => H(+) + oleanolate 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11758", "l": "AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein] => ATP + biotin + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928627", "l": "EPHB phosphorylates TIAM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27739", "l": "2'-deoxyguanosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018643", "l": "carbon disulfide oxygenase activity", "d": ["Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004639", "l": "phosphoribosylaminoimidazolesuccinocarboxamide synthase activity", "d": ["Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70573", "l": "argininosuccinate <=> fumarate + arginine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948800", "l": "TNKS and TNKS2 PARylate PTEN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44427", "l": "a fatty acyl-CoA + heptadecasphing-4-enine <=> CoA + H(+) + N-acyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76391", "l": "glycylglycylglycine(out) + n H(+)(out) = glycylglycylglycine(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43423", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP <=> 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944223", "l": "Association of procollagen type V (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52060", "l": "12-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-octadecenoate + 12-hydroxyoctadecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9853389", "l": "FIGNL1 binds RAD51 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853309", "l": "Autocatalytic phosphorylation of FGFR3 fusions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77732", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol => 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48669", "l": "20-hydroxy-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] => 20-oxo-leukotriene B4 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450690", "l": "hp-IRAK1,hp-IRAK4 bind Pellino1,2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54058", "l": "(2E,6E)-hedycaryol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8858369", "l": "ACVRL1 binds BMP9,BMP10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761173", "l": "Expression of PAX8 in intermediate mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.202", "l": "\"multisite-specific tRNA:(cytosine-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17735", "l": "CO2 + pyruvate => acetylenedicarboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209163", "l": "CI transports from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432164", "l": "Ca2+ influx into the post-synaptic cell (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16568", "l": "2-oxoglutarate + L-histidine <=> 3-(imidazol-5-yl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618085", "l": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705925", "l": "Androgens binds AR (in the HSP90 chaperone complex) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23876", "l": "protoaphin aglucone = H2O + xanthoaphin", "d": [], "t": []}, {"i": "EC:4.2.1.73", "l": "\"protoaphin-aglucone dehydratase (cyclizing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41459", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + an N-acylsphing-4-enine 1-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32983", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + 2 H2O = 2 a carboxylate + 2 H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168947", "l": "Ligand binds to TLR10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015095", "l": "magnesium ion transmembrane transporter activity", "d": ["Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4722133", "l": "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3772435", "l": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15041", "l": "bis-D-fructose 2',1:2,1'-dianhydride + H2O = inulobiose", "d": [], "t": []}, {"i": "EC:4.2.1.179", "l": "\"difructose-anhydride-I synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33742", "l": "2 H(+) + hexadecanoate + NADH <=> H2O + hexadecanal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432121", "l": "LDL binds to LRP8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52316", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8869568", "l": "NPM1 binds TFAP2A homodimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-171106", "l": "LDLR:LDL complex => LDLR + LDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806974", "l": "MET dimers autophosphorylate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371527", "l": "HSF1 trimer translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29107", "l": "H(+) + NADH + ubiquinone-8 = NAD(+) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358525", "l": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690873", "l": "ACO1 binds 4Fe-4S (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18916", "l": "a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9839405", "l": "InhibinA-TGFBR3 binding to ACVR2A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76896", "l": "2-hexyl-5-pentylresorcinol + O2 + reduced [NADPH--hemoprotein reductase] => 2-hexyl-5-(5-hydroxypentyl)resorcinol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60277", "l": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53290", "l": "5-dehydro-L-gluconate + H(+) => 3-dehydro-scyllo-inosose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51659", "l": "keto-D-tagaturonate <=> keto-D-fructuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24544", "l": "H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.3.13", "l": "\"protein-lysine 6-oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693478", "l": "HTR1A binds HTR1A agonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65632", "l": "a sphingoid base + tetracosanoyl-CoA = an N-tetracosanoyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69506", "l": "H2O2 + N-acetyl-D-glucosamino-1,5-lactone => N-acetyl-D-glucosamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008714", "l": "AMP nucleosidase activity", "d": ["Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61133", "l": "(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + kaempferol + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209925", "l": "DIT and MIT combine to form triiodothyronine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44929", "l": "2-oxoheptanedioate + acetyl-CoA + H2O => (R)-trihomocitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234172", "l": "Nuclear VBC complex ubiquitinylates HIF-alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806674", "l": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858475", "l": "TNFSF9 binds TNFRSF9 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70870", "l": "L-alanine(out) + L-glutamine(in) + Na(+)(out) <=> L-alanine(in) + L-glutamine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38190", "l": "19-oxotestosterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 17beta-estradiol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6781840", "l": "ERCC6 binds stalled RNA Pol II (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1638104", "l": "UGCG transfers glucose to ceramide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70354", "l": "beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O <=> beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26235", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + plaunotol => (2E,6E,10E)-geranylgeraniol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33600", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-hexacosanoylsphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-hexacosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932309", "l": "NFE2L2 translocates from cytosol to nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62934", "l": "acetate + cytidine + H(+) => H2O + N(4)-acetylcytidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.67", "l": "\"thiopurine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070635", "l": "nicotinamide riboside hydrolase activity", "d": ["Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392513", "l": "Rap1 signal termination by Rap1GAPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25474", "l": "diphosphate + gamma-himachalene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111253", "l": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67286", "l": "(1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione => (2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.11.2", "l": "\"exodeoxyribonuclease III\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75949", "l": "RNA Polymerase II Promoter Opening: First Transition (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25815", "l": "H2O + N(1)-acetylspermidine + O2 <=> 3-acetamidopropanal + H2O2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25987", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5R)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034577", "l": "N-isopropylacetaniline monooxygenase activity", "d": ["Catalysis of the reaction: N-isopropylacetanilide + 1/2 O2 = acetanilide + acetone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987063", "l": "IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59042", "l": "4alpha-carboxy-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O => 4alpha-formyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-166015", "l": "Association of LBP with LPS (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29006", "l": "H(+)(out) + L-homoserine(in) <=> H(+)(in) + L-homoserine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692408", "l": "NPR2 binds NPPC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035447", "l": "mycothiol synthase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol-2-(L-cysteinylamido)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + coA + H+. Mycothiol is also known as AcCys-GlcN-Ins and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as Cys-GlcN-Ins or desacetylmycothiol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50284", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443926", "l": "Thrombopoietin binds the thrombopoietin receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28448", "l": "1-deoxy-D-xylulose(out) => 1-deoxy-D-xylulose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45945", "l": "12-methyltridecanoyl-CoA + 3 H(+) + 3 malonyl-CoA => 4-hydroxy-6-(13-methyl-2-oxotetradecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858298", "l": "HRASLS transfer acyl group from PC to PE to form NAPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9853389", "l": "FIGNL1 binds RAD51 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29582", "l": "Fe(2+)(in) + H(+)(in) <=> Fe(2+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57617", "l": "dihydro-ML-236C-[compactin nonaketide synthase] + H2O => dihydro-ML-236C carboxylate + H(+) + holo-[compactin nonaketide synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52929", "l": "3',3'-c-di-GMP + 2 H2O => 2 GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35369", "l": "isoheptadecanoyl-coA + NADP(+) => (2E)-15-methylhexadecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159843", "l": "Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65931", "l": "3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine <=> 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000074", "l": "TCN2 binds RCbl in the circulation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5620914", "l": "ARF4:GTP binds VxPx-motifs of membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.923250621671642", "identifiers": [{"i": "GO:0070568", "l": "guanylyltransferase activity", "d": ["Catalysis of the transfer of a guanylyl group to an acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70079", "l": "2-oxoglutarate + clavatol + O2 = CO2 + hydroxyclavatol + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33918", "l": "4-(methylamino)butanoate + H2O + O2 <=> H2O2 + methylamine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63939", "l": "3 a ubiquinone + protoporphyrinogen IX <=> 3 a ubiquinol + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72621", "l": "Ribosomal scanning  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9011952", "l": "ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9821982", "l": "SRPK1 phosphorylates PRM1 in PRM1:dsDNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77651", "l": "2 [4-(deca-1,8-diyl)-2,5-dioxo-2,5-dihydro-3-furanyl]acetate + H(+) = 2-[(1R,8S,14R,15R)-11-hydroxy-14,15-bis[(6E)-oct-6-en-1-yl]-3,5,9-trioxo-4,10-dioxatetracyclo[9.4.0.0(2,6).0(8,12)]pentadeca-2(6),12-dien-8-yl]acetate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60176", "l": "5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O = 5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29298", "l": "aldehydo-D-galacturonate(out) + H(+)(out) <=> aldehydo-D-galacturonate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629869", "l": "KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52551", "l": "L-threonate + NAD(+) <=> 2-dehydro-L-erythronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30715", "l": "(2E)-geraniol = (S)-linalool", "d": [], "t": []}, {"i": "EC:5.4.4.4", "l": "\"geraniol isomerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15397", "l": "dichloromethane + H2O = 2 chloride + formaldehyde + 2 H(+)", "d": [], "t": []}, {"i": "EC:4.5.1.3", "l": "\"dichloromethane dehalogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832083", "l": "HNF1B binds the DLL1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23767", "l": "diphosphate + L-serine <=> H(+) + O-phospho-L-serine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64501", "l": "acetyl-CoA + H(+) + 3 malonyl-CoA + S-adenosyl-L-methionine => 3-methylorsellinate + 3 CO2 + 4 CoA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177107", "l": "Secretion and activation of the latent large complex of TGF-beta-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14234", "l": "a 2-acyl-sn-glycerol 3-phosphate + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11943", "l": "2 H(+) + H2O + L-citrulline <=> CO2 + L-ornithine + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66582", "l": "adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+) => 3'-phosphoadenylyl sulfate + bisphenol A", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69685", "l": "CHEK2 phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205262", "l": "Direct recruitment of PI3K to p-KIT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.3.1.24", "l": "\"phenylalanine ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22075", "l": "ATP + L-ribulose <=> ADP + H(+) + L-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9842669", "l": "Active LTK recruits GRB2:SOS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64314", "l": "dihydrogeodin + 2 FAD + H(+) + 4 H2O => 2 chloride + 2 FADH2 + 2 O2 + sulochrin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78100", "l": "a 1-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70244", "l": "an N-acylsphing-4-enine + UDP-alpha-D-xylose => a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75742", "l": "10-oxo-(11E)-octadecenoate + H(+) + NADH <=> 10-oxooctadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29261", "l": "(2R,3R)-tartrate(in) + succinate(out) => (2R,3R)-tartrate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2995376", "l": "BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18599", "l": "NADH + 2 oxidized [rubredoxin] => H(+) + NAD(+) + 2 reduced [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607004", "l": "Soluble PROCR binds PRTN3:CD177 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77094", "l": "Formation of cap binding complex (CBC) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44141", "l": "CoA + 2 H(+) + oxidized [flavodoxin] + pyruvate => acetyl-CoA + CO2 + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3700997", "l": "TP53 binds the MDM2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004130", "l": "cytochrome-c peroxidase activity", "d": ["Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29503", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + patchoulol", "d": [], "t": []}, {"i": "EC:4.2.3.70", "l": "\"patchoulol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36356", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine => 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.124", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708275", "l": "PDE4A binds PDE4A inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73385", "l": "thiamine diphosphate(out) + thiamine phosphate(in) => thiamine diphosphate(in) + thiamine phosphate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59312", "l": "D-galactose + O2 = D-galactono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853792", "l": "RET tyrosine phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168862", "l": "Association of HA into rafts (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74730", "l": "Insulin degradation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72621", "l": "Ribosomal scanning  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1364044", "l": "PRLR:JAK2 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38501", "l": "a 2,3-diacyl-sn-glycerol + a fatty acid + H(+) => a triacyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58422", "l": "3-methyl-2-butenal + H(+) + NADPH => NADP(+) + prenol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74739", "l": "3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine = 7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103056", "l": "gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: gibberellin A53 + O2 + 2-oxoglutarate = gibberellin A44 diacid + carbon dioxide + succinate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63918", "l": "5-fluorouridine 5'-phosphate + ADP + H(+) => 5-fluorouridine + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44707", "l": "a 2,3-saturated acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71229", "l": "2 Na(+)(in) + selenocyanate(in) => 2 Na(+)(out) + selenocyanate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12909", "l": "2 Fe(II)-[cytochrome] + 2 H(+) + nitrate = 2 Fe(III)-[cytochrome] + H2O + nitrite", "d": [], "t": []}, {"i": "EC:1.9.6.1", "l": "\"nitrate reductase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158750", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9639286", "l": "RRAGC,D exchanges GTP for GDP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73594", "l": "CTP(out) + dUTP(in) <=> CTP(in) + dUTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803875", "l": "SFN dimer binds CDK1 and CCNB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16438", "l": "glutathione + RX => a halide anion + an S-substituted glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23203", "l": "H2O + N(6)-methyl-L-lysine + O2 <=> formaldehyde + H2O2 + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629245", "l": "NEIL3 D132V does not cleave 5-guanidinohydantoin (Gh) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59704", "l": "D-cellohexaono-1,5-lactone + H2O = D-cellohexaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033887", "l": "chondro-4-sulfatase activity", "d": ["Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H+ + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62902", "l": "alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-D-GlcNAc + GDP + H(+) => alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-D-GlcNAc + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42018", "l": "17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + H(+) + NADH => cortisone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2471621", "l": "Endostatin degradation by cathepsins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-190182", "l": "UROD decarboxylates URO1 to COPRO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64115", "l": "an N-acyl-L-phenylalanine + H2O <=> a fatty acid + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.57", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43047", "l": "hexadecasphinganine + octadecanoyl-CoA <=> CoA + H(+) + N-octadecanoylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669013", "l": "EDA-3 binds EDA2R (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-216045", "l": "Collagen type I binds integrin alpha11beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750016", "l": "CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11640", "l": "a (2R,3R)-flavan-3-ol + 2 NAD(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610752", "l": "GLI3R translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24960", "l": "apo-[aequorin] + 3 Ca(2+) + coelenterazine + O2 = [excited state blue fluorescent protein] + CO2", "d": [], "t": []}, {"i": "EC:1.13.12.24", "l": "\"calcium-regulated photoprotein\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-508451", "l": "PTK2B is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047982", "l": "homocysteine desulfhydrase activity", "d": ["Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31556", "l": "(5S)-5-amino-3-oxohexanoate + acetyl-CoA => (3S)-3-aminobutanoyl-CoA + acetoacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20130", "l": "AMP + H2O => adenine + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76070", "l": "an (S)-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-methionine <=> an (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22991", "l": "3-oxopropanoate + CoA + NADP(+) <=> acetyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77117", "l": "1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate => 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74213", "l": "APRT catalyzes the conversion of adenine to AMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617595", "l": "SGTA binds mislocalized membrane protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76426", "l": "N-atom dealkylation of caffeine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799246", "l": "CHEK1 phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018623", "l": "benzoate 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805035", "l": "TP53 binds STK11 and NUAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612448", "l": "MXD4 gene expression is stimulated by ERBB4s80 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857348", "l": "Activated CEBPB stimulates transcription of CDKN2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45296", "l": "a sphingosylphosphocholine + H2O = a sphingoid base + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18228", "l": "[N-(6-aminohexanoyl)](n) + H2O <=> 6-aminohexanoate + [N-(6-aminohexanoyl)](n-1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003914", "l": "DNA (6-4) photolyase activity", "d": ["Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350598", "l": "Arginine<=>Agmatine+CO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20902", "l": "benzyl alcohol + CO2 + glycine => H(+) + H2O + N-benzyloxycarbonylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64128", "l": "H2O + N-octadecanoyl-L-phenylalanine = L-phenylalanine + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854052", "l": "Formation of the SCF-FBXL7 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001785", "l": "prostaglandin J receptor activity", "d": ["Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9646679", "l": "PolyUb-Misfolded proteins bind vimentin to form aggresome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13215", "l": "2 H(+) + NADPH + succinate => H2O + NADP(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76978", "l": "1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O <=> (9Z)-octadecenoate + 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56723", "l": "2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102953", "l": "hypoglycin A gamma-glutamyl transpeptidase activity", "d": ["Catalysis of the reaction: glutathionate + hypoglycin A = L-cysteinylglycine + hypoglycin B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786421", "l": "CHIA hydrolyses chitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824236", "l": "MSGN1 and LEF1:CTNNB1 bind the DLL1 gene in presomitic mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654562", "l": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12744", "l": "ADP + H(+) + H2O <=> IDP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047571", "l": "3-oxosteroid 1-dehydrogenase activity", "d": ["Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48665", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72923", "l": "O2 + proatranorin II + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57852", "l": "a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73618", "l": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004569", "l": "glycoprotein endo-alpha-1,2-mannosidase activity", "d": ["Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22069", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) => (2S)-2-acetolactate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72287", "l": "2,2-dimethylsuccinate(out) + 3 Na(+)(out) = 2,2-dimethylsuccinate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000210", "l": "NAD+ diphosphatase activity", "d": ["Catalysis of the reaction: NAD+ + H2O = AMP + NMN."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033410", "l": "UAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UAC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63261", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH => 4-pyridoxate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3204318", "l": "cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9659568", "l": "ANO1 transports cytosolic Cl- to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809764", "l": "SBF1 binds MTMR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0099142", "l": "intracellularly ATP-gated ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17938", "l": "dihydroxyacetone phosphate => methylglyoxal + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26225", "l": "abieta-7,13-dien-18-al + H2O + NAD(+) = abieta-7,13-dien-18-oate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.74", "l": "\"abieta-7,13-dien-18-al dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33193", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA => a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41438", "l": "cholesteryl (9Z-octadecenoate) + CoA => (9Z)-octadecenoyl-CoA + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9834945", "l": "PINK1 phosphorylates Ub on MOM proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62446", "l": "H(+) + L-arginine + L-canaline => L-canavanine + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12792", "l": "an alditol + NADP(+) <=> an aldose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162729", "l": "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649664", "l": "NEIL1 cleaves FapyG from damaged DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-936802", "l": "ATP7A transports cytosolic Cu2+ to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62330", "l": "(+)-malbrancheamide + FADH2 => (+)-isomalbrancheamide B + chloride + FAD + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32298", "l": "2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH <=> 2 diphosphate + NADP(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701565", "l": "HDACs deacetylate p-STAT3 dimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40522", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46493", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944265", "l": "Association of procollagen type IV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62875", "l": "(3S)-9,10-dihydroxy-7-methoxy-3-(2-oxopropyl)-1H,3H,4H-naphtho[2,3-c]pyran-1-one + H(+) + NADPH + O2 <=> H2O + NADP(+) + semiviriditoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70098", "l": "(R)-5-methyl-tetronate + o-quinone methide <=> peniphenone D", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604731", "l": "Autocatalytic activation of MMP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33958", "l": "DIBOA + UDP-alpha-D-glucose <=> DIBOA beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28613", "l": "H2O + XTP <=> diphosphate + H(+) + XMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1614567", "l": "Excess homocysteine yields homolanthionine and H2S (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57227", "l": "glyoxal + GTP <=> N(2)-(1-hydroxy-2-oxoethyl)-GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71505", "l": "a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(out) => a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37789", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53477", "l": "1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol => (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10390", "l": "CO2 + GDP + phosphoenolpyruvate => GTP + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74387", "l": "formamide(out) = formamide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55624", "l": "an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + H2O = 3-methylcytosine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45168", "l": "2 (E)-sinapoyl-CoA + spermidine = 2 CoA + 2 H(+) + N(1),N(8)-bis[(E)-sinapoyl]-spermidine", "d": [], "t": []}, {"i": "EC:2.3.1.248", "l": "\"spermidine disinapoyl transferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800380", "l": "PTPRD binds IL1RAP-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23872", "l": "(R)-propane-1,2-diol + NAD(+) = (R)-lactaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47999", "l": "1,6-dihydro-beta-NAD + H(+) + O2 <=> H2O2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-435171", "l": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2534365", "l": "Slo3 Potassium Transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417122", "l": "Elongation and translocation of the telomeric chromosome end (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8868230", "l": "SNX9 recruits components of the actin polymerizing machinery (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189398", "l": "HMOX1 dimer, HMOX2 cleave heme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222546", "l": "AP-1 complex stimulates KDM6B transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027272", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38522", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016156", "l": "fumarate reductase (NADH) activity", "d": ["Catalysis of the reaction: NAD+ + succinate = fumarate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12631", "l": "(6S)-6-hydroxyhyoscyamine + CO2 + succinate => 2-oxoglutarate + L-hyoscyamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-549304", "l": "OCT3 mediates renal clearance of organic cations (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32191", "l": "H2O + L-glutamate + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-oxoglutarate + 2 H(+) + NH4(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22044", "l": "ATP + H(+)(in) + H2O + K(+)(out) = ADP + 2 H(+)(out) + K(+)(in) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.19", "l": "\"H(+)/K(+)-exchanging ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50416", "l": "L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17690", "l": "3'-phosphoadenylyl sulfate + glycochenodeoxycholate => adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266012", "l": "LTD4 is converted to LTE4 by DPEP1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51871", "l": "dimethylallyl diphosphate + umbelliferone <=> demethylsuberosin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001607", "l": "neuromedin U receptor activity", "d": ["Combining with neuromedin U to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710263", "l": "GZMB cleaves GSDME (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75346", "l": "adenosine(in) <=> adenosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36164", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate => ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10864", "l": "3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 = 2-(acetamidomethylene)succinate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5649764", "l": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.114", "l": "\"methanogen homoaconitase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61220", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + 1D-myo-inositol 3-phosphate = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173631", "l": "Activation of C1s (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77506", "l": "3-phenylpropanal + hydrogen cyanide <=> (2S)-2-hydroxy-4-phenylbutanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40003", "l": "ent-copalyl diphosphate = (Z)-biformene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54218", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O => 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822461", "l": "KDM5B demethylates histone H3 trimethyllysine-4 (H3K4me3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41734", "l": "[(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->4)-alpha-D-glucosyl](n) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29460", "l": "beta-alanine(in) + H(+)(in) => beta-alanine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15889", "l": "H2O + L-glutamine = L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210300", "l": "Interaction of DAP12 and TREM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34330", "l": "4-nitrophenol + H(+) + NADPH + O2 <=> 1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5635861", "l": "NUMB:ITCH binds GLI1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130194", "l": "ABL phosphorylates WAVEs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-741411", "l": "CYLD deubiquitinates NEMO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41265", "l": "15-oxo-prostaglandin A1 + H(+) + NADH => NAD(+) + prostaglandin A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2161961", "l": "EET(1) is hydrolysed to DHET(1) by EPHX2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47844", "l": "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098641", "l": "cadherin binding involved in cell-cell adhesion", "d": ["Any cadherin binding that occurs as part of the process of cell-cell adhesion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848804", "l": "HIF1A,EPAS1 promote PTK6 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28102", "l": "GDP-alpha-D-mannose + H2O = D-mannose + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72849", "l": "adenosine 3',5'-bisphosphate(out) + ADP(in) => adenosine 3',5'-bisphosphate(in) + ADP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53993", "l": "(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O => (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66583", "l": "3'-phosphoadenylyl sulfate + bisphenol A <=> adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37521", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2314686", "l": "ASA- acetylates PTGS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687097", "l": "p-S857 NCOA3 binds ETV4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65969", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O => 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419268", "l": "TUFM binds GTP displacing TSFM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693604", "l": "XRCC4:LIG4 ligates DNA DSB ends during NHEJ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18774", "l": "coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid protein] => Co(I)-[methylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9693111", "l": "RHOF auto-activates (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21688", "l": "a polyvinyl alcohol + n O2 = an oxidized polyvinyl alcohol + n H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.30", "l": "\"polyvinyl-alcohol oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78088", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21481", "l": "2-furoyl-CoA + A + H2O => 5-hydroxy-2-furoyl-CoA + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58003", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rg3 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112703", "l": "PTPN11 is phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66460", "l": "(2E,6E,10E,14E)-geranylfarnesol + H2O = 14betaH-scalarane-17alpha-19-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65339", "l": "chrodrimanin T + H(+) + NADPH + O2 <=> chrodrimanin A + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16777", "l": "ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.6", "l": "\"P-type K(+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139918", "l": "Phosphorylation of BIM by JNK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322041", "l": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-195378", "l": "Homodimerization of VEGF proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55596", "l": "a globoside NOR1 + UDP-N-acetyl-alpha-D-galactosamine = a globoside NORint + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839059", "l": "AFG3L2:SPG7 degrades SMDT1 (EMRE) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31751", "l": "chlorophyllide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 7(1)-hydroxychlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647643", "l": "GSDMD (1-275) binds bacterial cardiolipin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52329", "l": "L-arginine + O2 + reduced [flavodoxin] => H(+) + H2O + N(omega)-hydroxy-L-arginine + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097713", "l": "dolichol-phosphate-mannose synthase regulator activity", "d": ["Binds to and modulates the activity of dolichol-phosphate-mannose synthase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5685156", "l": "ATR phosphorylates RPA2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.14", "l": "\"L-iditol 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60264", "l": "L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.364", "l": "\"[histone H3]-lysine(4) N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5682388", "l": "Autophagosome maturation (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75869", "l": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357928", "l": "CLIP3 and CYLD bind TNF signaling complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.131", "l": "\"xylan alpha-1,2-glucuronosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61623", "l": "[(1->2)-beta-D-mannosyl](n) + GDP-alpha-D-mannose <=> [(1->2)-beta-D-mannosyl](n+1) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-964800", "l": "Neuromedin-U receptors bind neuromedins U, S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5227009", "l": "ABCF1 binds EIF2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44778", "l": "H(+) + menaquinol-6 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-6 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8931653", "l": "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25006", "l": "L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803391", "l": "TP53 binds the PCBP4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663232", "l": "FMNL1 binds RAC1:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57944", "l": "H(+) + H2O2 + harderoheme III = CO2 + 2 H2O + heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63658", "l": "1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0004152", "l": "dihydroorotate dehydrogenase activity", "d": ["Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684273", "l": "3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67987", "l": "N-acetyl-L-leucine <=> N-acetyl-D-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0008675", "l": "2-dehydro-3-deoxy-phosphogluconate aldolase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-176664", "l": "estrone + PAPS => estrone 3-sulfate + PAP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5624486", "l": "SFKs phosphorylates RAF1 on Y340,Y341 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38483", "l": "a 2,3-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0016274", "l": "protein-arginine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-992696", "l": "p53, SIN3A and MYB form a complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39503", "l": "(2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H(+) + NADPH = (13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35477", "l": "(S)-5'-oxoaverantin + H(+) + NADH => (1'S,5'S)-5'-hydroxyaverantin + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38966", "l": "ATP + H2O + leukotriene C4(in) <=> ADP + H(+) + leukotriene C4(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41885", "l": "dodecanoyl-[ACP] + H(+) + malonyl-[ACP] => 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047418", "l": "phthalyl amidase activity", "d": ["Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72348", "l": "Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) + veratrole => 3-methoxyphenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39539", "l": "(2E,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH = (19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728776", "l": "SARS-CoV-1 nsp1 binds to RCAN3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1254386", "l": "ERBB4s80 forms a complex with estrogen receptor ESR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69127", "l": "Formation of the Flap Intermediate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605535", "l": "Expression of SIRT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16282", "l": "ATP + dihydrostreptomycin 6-phosphate => ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61406", "l": "ADP + H(+) + N-(3-O-phospho-D-ribulosyl)-cadaverine => ATP + N-(D-ribulosyl)-cadaverine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14619", "l": "CoA-glutathione + H(+) + NADPH => CoA + glutathione + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29820", "l": "ATP + H2O + L-isoleucine(out) => ADP + H(+) + L-isoleucine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59831", "l": "H2O + S-inosyl-L-homocysteine <=> inosine + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428681", "l": "PXLP-SGPL1 cleaves sphingoid-1-phosphates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-981832", "l": "NMUR2 binds neuromedin-S (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982017", "l": "Active G alpha (q) binds RGS proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202443", "l": "Oligomerization of CARMA1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090390", "l": "PIAS1,2-1 SUMOylates AR with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033980", "l": "phosphonopyruvate decarboxylase activity", "d": ["Catalysis of the reaction: 3-phosphonopyruvate + 2 H+ = CO2 + phosphonoacetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381116", "l": "Phosphorylated IRE1 dimer binds ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52233", "l": "3 AH2 + 2 H(+) + heme b + 3 O2 => 3 A + Fe(2+) + 3 H2O + mycobilin a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015655", "l": "alanine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093331", "l": "Ras:GTP binds p120-RasGAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44431", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + glycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a 1-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58240", "l": "H2O + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] = ADP-D-ribose + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9858590", "l": "DLST transfers glutaryl to CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48418", "l": "a ganglioside GM2 (d18:1(4E)) + CMP + H(+) => a ganglioside GA2 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839363", "l": "TGFBR3 phosphorylation by TGFBR2 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854604", "l": "TBC1D16 accelerates GTP hydrolysis by RAB4A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9616368", "l": "MyrG-CDK5R1,2 bind CDK5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047308", "l": "alanine-oxomalonate transaminase activity", "d": ["Catalysis of the reaction: L-alanine + oxomalonate = aminomalonate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2466802", "l": "Defective ABCA4 does not transport NRPE from disc membranes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050051", "l": "leukotriene-B4 20-monooxygenase activity", "d": ["Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0009381", "l": "excinuclease ABC activity", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74516", "l": "(1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B => aspoquinolone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852481", "l": "Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702607", "l": "pexidartinib-resistant FLT3 mutants don't bind pexidartinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034852", "l": "4,4-dimethyl-3-oxopentanal dehydrogenase activity", "d": ["Catalysis of the reaction: 4,4-dimethyl-3-oxopentanal + H2O = 4,4-dimethyl-3-oxopentanoate + 3 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56004", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": [], "t": []}, {"i": "EC:3.2.1.209", "l": "\"endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734713", "l": "ORC6 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66370", "l": "4-methyl-5-oxo-octanedioyl-CoA + acetyl-CoA => 6-methyl-3,7-dioxodecanedioyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62763", "l": "4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098639", "l": "collagen binding involved in cell-matrix adhesion", "d": ["Any collagen binding that occurs as part of cell-matrix adhesion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047659", "l": "alpha-santonin 1,2-reductase activity", "d": ["Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190682", "l": "Connexin synthesis (generic) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34240", "l": "L-glutamate => 3-aminopentanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645394", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033435", "l": "AUA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AUA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675795", "l": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48658", "l": "5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31734", "l": "3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 <=> 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8937807", "l": "SRC phosphorylates RUNX3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619666", "l": "L-PRX:DRP2 binds dystroglycan and laminin-211 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41461", "l": "1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine => a 1,2-diacylglycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674018", "l": "BRAP binds RAS:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70994", "l": "SDH complex dehydrogenates succinate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40940", "l": "1-O-hexadecylglycerone 3-phosphate + H(+) + NADPH => 1-O-hexadecyl-sn-glycero-3-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047346", "l": "aldose-1-phosphate adenylyltransferase activity", "d": ["Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010429", "l": "methyl-CpNpN binding", "d": ["Binding to a methylated cytosine/unspecified/unspecified trinucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9754964", "l": "ADA deamidates RBV (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483174", "l": "PE is methylated to PC by PEMT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56586", "l": "propane-1,2-diol => 1,2-epoxypropane + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62150", "l": "dGDP + dTDP => dGTP + dTMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51315", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine <=> H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372529", "l": "Release of acetylcholine at the synapse (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1369115", "l": "SHP2 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9640195", "l": "RRAGA,B hydrolyzes GTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.55", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625574", "l": "Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655245", "l": "Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809764", "l": "SBF1 binds MTMR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33959", "l": "2-oxoglutarate + neomycin C = 6'''-deamino-6'''-oxoneomycin C + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.95", "l": "\"neomycin C transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42972", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a cardiolipin + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11400", "l": "GDP-6-deoxy-alpha-D-altrose + sordaricin = 4'-O-demethylsordarin + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.353", "l": "\"sordaricin 6-deoxyaltrosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-434027", "l": "Dimerization of Phospho-IRF3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32262", "l": "beta-D-fructose 1-phosphate + methylglyoxal <=> 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68714", "l": "(1S,2S,4R)-beta-elemene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428127", "l": "SPTLC complexes transfer acyl-CoA onto serine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70442", "l": "2-oxoglutarate + an N(3)-methyl-2'-deoxycytidine in double-stranded DNA + O2 <=> a 2'-deoxycytidine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8939959", "l": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79087", "l": "an L-alpha-amino acid + cholate = an N-choloyl-L-alpha-amino acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42840", "l": "acetyl-CoA + 6 H(+) + 5 malonyl-CoA + 2 NADPH = 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 6 CoA + 3 H2O + 2 NADP(+)", "d": [], "t": []}, {"i": "EC:2.3.1.237", "l": "\"neocarzinostatin naphthoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41349", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627072", "l": "RHOQ binds GOPC:CFTR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35948", "l": "dihydrochanoclavine-I aldehyde + NADP(+) => chanoclavine-I aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53685", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 => 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14718", "l": "D-erythrose 4-phosphate + H2O + phosphoenolpyruvate => 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32398", "l": "(1S,2S,4S)-dihydrocarveol + NAD(+) <=> (1S,4S)-dihydrocarvone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.224", "l": "\"acetyl-CoA-benzylalcohol acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38954", "l": "ATP + H2O + sphing-4-enine 1-phosphate(in) <=> ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.47", "l": "\"glucose 1-dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45851", "l": "(3R)-3-hydroxydodecanoyl-CoA + NADP(+) <=> 3-oxododecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666129", "l": "CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839072", "l": "HTRA2 degrades APP (Amyloid-beta precursor protein) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62079", "l": "D-galactose 6-phosphate + NAD(+) <=> 6-phospho-D-galactono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24549", "l": "an N(6)-acyl-L-lysine + H2O => a carboxylate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852324", "l": "GTSE1 binds PLK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5603467", "l": "Activated protein C is released from PROCR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018741", "l": "linear primary-alkylsulfatase activity", "d": ["Catalysis of the reaction: a primary linear alkyl sulfate ester + H2O = a primary alcohol + H+ + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266070", "l": "LTC4 is exported from the cytosol by ABCC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190261", "l": "FGFR3c binds to FGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1169406", "l": "ISGylation of host proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31231", "l": "4-acetamidobutanal + H2O + NAD(+) = 4-acetamidobutanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50523", "l": "acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62568", "l": "H2O + S-benzyl-L-cysteinylglycine = glycine + S-benzyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216064", "l": "Interaction of integrin alpha8beta1 with Tenascin-C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17969", "l": "ATP + L-lysine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine", "d": [], "t": []}, {"i": "EC:6.3.2.7", "l": "\"UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23927", "l": "pppGp(2'-5')A <=> 2',3'-cGAMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70316", "l": "beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol => cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35405", "l": "(3R)-vestitone + H(+) + NADPH => (3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41873", "l": "3-oxododecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxydodecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71345", "l": "chloride(in) + L-histidine(in) + 2 Na(+)(in) => chloride(out) + L-histidine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106301", "l": "arachidonic acid 5,6-epoxygenase activity", "d": ["Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-5,6-epoxyeicosatrienoic acid."], "t": []}, {"i": "RHEA:49936", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851908", "l": "Activated MET binds GAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247844", "l": "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10417", "l": "fumarate + toluene => 2-benzylsuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18990", "l": "H(+) + L-valine => 2-methylpropan-1-amine + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23209", "l": "acetyl-CoA + trans-glutaconate => (2E)-glutaconyl-CoA + acetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664867", "l": "NBR1 binds MAP1LC3B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76493", "l": "acetate + vanillin => (E)-ferulate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9716947", "l": "ESR1 binds ESR1 agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31243", "l": "H2O + L-4-hydroxyglutamate semialdehyde + NAD(+) = (4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66068", "l": "4-methyl-2-oxopentanoate + L-kynurenine = H2O + kynurenate + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56425", "l": "H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58464", "l": "a neolactoside nLc4Cer + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51874", "l": "diphosphate + osthenol => dimethylallyl diphosphate + umbelliferone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161779", "l": "LXA4 is oxidised to 15k-LXA4 by HPGD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909719", "l": "Recruitment of STAT2 to p-IFNAR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-443778", "l": "Interaction of L1 with Laminin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8879117", "l": "POMGNT2 transfers GlcNAc to Man-DAG1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.30", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694421", "l": "PP6 dephosphorylates SEC24 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14845", "l": "L-aspartate 4-semialdehyde + pyruvate = (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72428", "l": "chloride(in) + K(+)(in) => chloride(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.393", "l": "\"MMP alpha-(1->4)-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051753", "l": "mannan synthase activity", "d": ["Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-(1->4)-linked mannan backbone in substrates such as galactomannan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72284", "l": "a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) => a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018678", "l": "4-hydroxybenzoate 1-hydroxylase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43433", "l": "butan-1-ol + 2 Fe(III)-[cytochrome c] => butanal + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199112", "l": "CRTAM binds to NECL2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68688", "l": "CDC6 association with ORC(1-6) at replication origins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66901", "l": "acetyl-CoA + L-tryptophan + malonyl-CoA => CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68605", "l": "(2S)-3-sulfopropanediol => H(+) + hydroxyacetone + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102874", "l": "1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-16:0-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-16:0-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53869", "l": "2 H(+) + NADH + O2 + phenazine-1-carboxylate => 1-hydroxyphenazine + CO2 + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450488", "l": "BRF1 Complex recruits RNA degradation activities (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68177", "l": "2-oxoglutarate + N-geranyl-L-glutamate + O2 => CO2 + dainate A + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2090043", "l": "SGSH hydrolyses Heparan sulfate chain(7) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61873", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 => 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61878", "l": "1-O-methyl-8-hydroperoxy-20-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0030984", "l": "kininogen binding", "d": ["Binding to a kininogen, a kinin precursor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28917", "l": "4-aminobutanoate(out) + H(+)(out) => 4-aminobutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56710", "l": "16alpha-hydroxy-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60224", "l": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(27)-[histone H3] + 2 succinate", "d": [], "t": []}, {"i": "EC:1.14.11.68", "l": "\"[histone H3]-trimethyl-L-lysine(27) demethylase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638046", "l": "ACY3:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647619", "l": "GSDMD forms ring‐shaped oligomers  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420143", "l": "p-6Y-VEGFR2 binds SH2D2A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64471", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) <=> 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25169", "l": "6-hydroxyhexan-6-olide => 6-oxohexanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44210", "l": "12-methyltridecanoyl-CoA + AMP + diphosphate => 12-methyltridecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851908", "l": "Activated MET binds GAB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840470", "l": "PSAP(195-273) dimer:PE binds and mobilizes ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66229", "l": "asc-C13-CoA + O2 => asc-DeltaC13-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15036", "l": "O2 + pyridoxine <=> H2O2 + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73182", "l": "S-adenosyl-L-methionine + scutellarein <=> H(+) + S-adenosyl-L-homocysteine + scutellarein 4'-methyl ether", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35365", "l": "isopentadecanoyl-CoA + NADP(+) => (2E)-13-methyltetradecenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876446", "l": "p-ULK1 phosphorylates DENND3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-165680", "l": "Formation of active mTORC1 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052659", "l": "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696482", "l": "CTF1 binds LIFR:JAKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54503", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> beta-geranylfarnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018677", "l": "pentachlorophenol monooxygenase activity", "d": ["Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58871", "l": "24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 <=> 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977602", "l": "Complement factor I binds to MCP, CR1:C4b, C3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018573", "l": "2-aminophenol 1,6-dioxygenase activity", "d": ["Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159050", "l": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32235", "l": "(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40797", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170965", "l": "(Frs2)Rap1-GTP binds to and activates B-Raf (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164524", "l": "Fusion of viral membrane with host cell membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194310", "l": "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41649", "l": "aniline + ATP + L-glutamate => ADP + N(5)-phenyl-L-glutamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12625", "l": "(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose = D-glucose + sinapoyl (S)-malate", "d": [], "t": []}, {"i": "EC:2.3.1.92", "l": "\"sinapoylglucose--malate O-sinapoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65739", "l": "2-oxoglutarate + O2 + octyl sulfate <=> CO2 + H(+) + octanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373745", "l": "SDK1 homophillic interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5333658", "l": "CLAT:AP1:CLVS bind PI(3,5)P2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158311", "l": "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638006", "l": "ARL3 hydrolyzes GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59466", "l": "H(+) + NADPH + octadecanal => NADP(+) + octadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63517", "l": "biphenyl-2,2',3-triol + H(+) + NADH + O2 => biphenyl-2,2',3,3'-tetraol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20367", "l": "H(+) + N-methylethanolamine phosphate + S-adenosyl-L-homocysteine => phosphoethanolamine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71800", "l": "Ca(2+)(in) + H(+)(out) => Ca(2+)(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5638006", "l": "ARL3 hydrolyzes GTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63637", "l": "a medium-chain fatty acyl-AMP + holo-[ACP] => a medium-chain fatty acyl-[ACP] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684118", "l": "ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25859", "l": "(9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-874087", "l": "SGT1 binds HSP90 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57006", "l": "CoA + H(+) + N(beta)-acetylstreptothricin D => acetyl-CoA + streptothricin D", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428961", "l": "Phosphorylation of cPLA2 by MAPK p38 alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18747", "l": "2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+) => 2 juglone + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72722", "l": "eIF2 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33633", "l": "AMP + diphosphate + octanoyl-CoA => ATP + CoA + octanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9615249", "l": "ARBs bind AGRT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73192", "l": "(2R,3S,11R)-aszonalenin + acetyl-CoA => (2R,3S,11R)-acetylaszonalenin + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32221", "l": "gamma-carotene => all-trans-lycopene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54973", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14193", "l": "3-hydroxybenzoate + AH2 + O2 = 2,3-dihydroxybenzoate + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.23", "l": "\"3-hydroxybenzoate 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56064", "l": "3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.42", "l": "\"UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34391", "l": "beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 UDP-alpha-D-galactofuranose = [beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->6)]14-beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + 28 H(+) + 28 UDP", "d": [], "t": []}, {"i": "EC:2.4.1.288", "l": "\"galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003947", "l": "(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047872", "l": "dolichol O-acyltransferase activity", "d": ["Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875816", "l": "STAT3 binds activated MET receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21736", "l": "(3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70241", "l": "PCK1 phosphorylates OA to yield PEP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052922", "l": "hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9731632", "l": "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216133", "l": "Dissociation of CI from COS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2028661", "l": "Phosphorylation of WWTR1 (TAZ) by LATS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44387", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + dodecanoyl-CoA <=> 1-heptadecanoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8866551", "l": "CFTR binds components of the ERAD machinery for ubiquitination and degradation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69683", "l": "daidzein 7-O-beta-D-glucoside + H2O = beta-D-glucose + daidzein + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420131", "l": "The PACAP receptor binds PACAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863471", "l": "LDLR is bound by DAB2 and ARH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419452", "l": "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16757", "l": "NADP(+) + trypanothione = H(+) + NADPH + trypanothione disulfide", "d": [], "t": []}, {"i": "EC:1.8.1.12", "l": "\"trypanothione-disulfide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508292", "l": "SYK binds IL2RB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938853", "l": "CDK6 binds RUNX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047298", "l": "(S)-3-amino-2-methylpropionate transaminase activity", "d": ["Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5632677", "l": "PTCH is internalized (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9009950", "l": "PDE12 cleaves 2'-5' oligoadenylates  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-449077", "l": "Interleukin-16 is secreted (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23761", "l": "H(+) + H2 + oxidized coenzyme F420-(gamma-L-Glu)(n) => reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75344", "l": "adenosine(in) => adenosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33501", "l": "3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2 => H(+) + prephenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59511", "l": "fumarate + L-cysteinyl-[protein] <=> S-(2-succinyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420977", "l": "Ca permeable AMPA receptor ligand binding (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814096", "l": "ARL1:GTP binds SCOC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-112429", "l": "Formation of FACT complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55535", "l": "H(+) + H2O + L-phenylalanine + O2 <=> 2-phenylacetaldehyde + CO2 + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15433", "l": "(2S)-naringenin + dimethylallyl diphosphate = diphosphate + sophoraflavanone B", "d": [], "t": []}, {"i": "EC:2.5.1.70", "l": "\"naringenin 8-dimethylallyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65142", "l": "A + berkeleyone A + H2O => AH2 + O2 + protoaustinoid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6806647", "l": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46434", "l": "(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin] => (25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002460", "l": "P4HB binds Collagen chains (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71303", "l": "RPE dimers isomerise RU5P to XY5P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68720", "l": "lanosterol + O2 + reduced [NADPH--hemoprotein reductase] = 26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50973", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109480", "l": "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9842833", "l": "SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-156910", "l": "Formation of eEF1B complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102362", "l": "esculetin 3-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: esculetin + UDP-alpha-D-glucose = 3-O-beta-D-glucosyl-esculetin + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5695989", "l": "ACAD11 dehydrogenates BH-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418106", "l": "Packaging of telomere ends (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25265", "l": "2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60279", "l": "L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45484", "l": "H(+) + pyruvate = acetaldehyde + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482868", "l": "PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24321", "l": "an L-polyhomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => an L-N-hydroxypolyhomomethionine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9838289", "l": "CLPXP degrades mitochondrial matrix proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10432", "l": "2-(acetamidomethylene)succinate + H(+) + 2 H2O = acetate + CO2 + NH4(+) + succinate semialdehyde", "d": [], "t": []}, {"i": "EC:3.5.1.29", "l": "\"2-(acetamidomethylene)succinate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420131", "l": "The PACAP receptor binds PACAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13990", "l": "alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose => alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30416", "l": "H(+) + 2 NADPH + O2 + octadecanal => formate + H2O + heptadecane + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33251", "l": "2 sucrose = 6-kestotriose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45139", "l": "2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate <=> 7,8-dihydroneopterin 3'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47919", "l": "ATP + N-hexanoyl-(4R)-hydroxysphinganine <=> ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11212", "l": "indole + O2 = 2-formamidobenzaldehyde", "d": [], "t": []}, {"i": "EC:1.13.11.17", "l": "\"indole 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52521", "l": "O2 + prostaglandin E1 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy prostaglandin E1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191366", "l": "Squalene 2,3-epoxide cyclizes, forming lanosterol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56574", "l": "a globoside Gb3Cer + H(+) + UDP => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-904830", "l": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38039", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (5Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140449", "l": "centromere-nuclear envelope anchor activity", "d": ["The binding activity of a molecule that brings together the centromeric region of a chromosome and the inner nuclear membrane by interacting with both the centromere/kinetochore complex and the nuclear membrane, in order to establish and maintain the centromere/kinetochore location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57267", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-GDP <=> GDP + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607759", "l": "TRIKA2 binds K63polyUb-TRAF6 oligomer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191299", "l": "Squalene is oxidized to its epoxide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102896", "l": "colnelenate synthase activity", "d": ["Catalysis of the reaction: (10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate = colnelenate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649735", "l": "Intrinsic nucleotide exchange on RAS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31499", "l": "a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.275", "l": "\"neolactotriaosylceramide beta-1,4-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.1.9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-216050", "l": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446648", "l": "IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33621", "l": "AMP + diphosphate + tetradecanoyl-CoA => ATP + CoA + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71728", "l": "citrate(out) + fumarate(in) => citrate(in) + fumarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35596", "l": "benzene-1,2,4-triol + O2 => 2 H(+) + maleylacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13504", "l": "ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] <=> ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1254291", "l": "ERBB4s80 binds STAT5A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1234164", "l": "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043997", "l": "histone H4K12 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3828025", "l": "DCN (decorin) degradation by MMP14 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52602", "l": "CoA + H(+) + N-propanoyl-L-methioninate => L-methionine + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24182", "l": "CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] => 2-hydroxyisobutanoyl-CoA + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53111", "l": "2-hydroxyestrone + S-adenosyl-L-methionine <=> 2-hydroxy-3-methoxy-estrone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982162", "l": "p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53235", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509793", "l": "NUDT16 hydrolyses dIDP to dIMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47183", "l": "(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) <=> (25R)-7alpha,26-dihydroxycholest-4-en-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865482", "l": "KMT2A (MLL) binds RUNX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41018", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol <=> 1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20135", "l": "H(+) + indole-3-pyruvate + NADH => 3-(indol-3-yl)lactate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49073", "l": "dibenzothiophene + 2 FMNH2 + 2 O2 => dibenzothiophene 5,5-dioxide + 2 FMN + 2 H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29845", "l": "ADP + phosphate + propanoyl-CoA => ATP + CoA + propanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6801762", "l": "REG3A oligomerize to form a pore complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58630", "l": "FADH2 + H2O + NADP(+) + rifamycin SV hemiaminal => FADH2-C4alpha-hydroperoxide + H(+) + NADPH + rifamycin SV", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75047", "l": "N(omega),N(omega)-dimethyl-L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5656070", "l": "FGFBPs bind FGFs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-934559", "l": "SPRY2 is phosphorylated by phosphorylated MNK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634402", "l": "Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31563", "l": "H2O + leukotriene C4 = L-glutamate + leukotriene D4", "d": [], "t": []}, {"i": "EC:3.4.19.14", "l": "\"leukotriene-C4 hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1253343", "l": "WWOX binds ERBB4s80 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047377", "l": "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity", "d": ["Catalysis of the reaction: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27956", "l": "diphosphate + presilphiperfolan-8beta-ol => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034200", "l": "D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase activity", "d": ["Catalysis of the reaction: D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008412", "l": "CDK4 phosphorylates RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033520", "l": "TYSND1 cleaves TYSND1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22966", "l": "CO2 + putrescine => H(+) + L-ornithine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24367", "l": "H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD(+) <=> 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162194", "l": "COQ7:COQ9 octamer hydroxylates DMQ10H2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37718", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine <=> 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63429", "l": "ATP + H2O + levoglucosan => ADP + D-glucose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62211", "l": "3-methylphenol + O2 + reduced [NADPH--hemoprotein reductase] <=> 3-hydroxybenzyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936214", "l": "GUCY2C trimer binds GUCA2A,B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73576", "l": "(E,E)-piperate + ATP + H(+) => (E,E)-piperoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12841", "l": "pyridoxamine + pyruvate = L-alanine + pyridoxal", "d": [], "t": []}, {"i": "EC:2.6.1.30", "l": "\"pyridoxamine--pyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38017", "l": "6-geranylgeranyl-2-methylbenzene-1,4-diol => delta-tocotrienol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44413", "l": "3-demethylubiquinol-10 + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + ubiquinol-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68769", "l": "4 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022F + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6790038", "l": "Expression of HSP90B1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9024890", "l": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029272", "l": "Release of PLCG from FCGR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2167942", "l": "Collagen type XIII ectodomain shedding (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52123", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102163", "l": "3-hydroxyacyl-CoA-acyl carrier protein transferase activity", "d": ["Catalysis of the reaction: coenzyme A + a (3R)-3-hydroxyacyl-[acyl-carrier protein] = a (3R)-3-hydroxyacyl-CoA + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17257", "l": "O2 + reduced [NADPH--hemoprotein reductase] + vinorine = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + vomilenine", "d": [], "t": []}, {"i": "EC:1.14.14.104", "l": "\"vinorine hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109822", "l": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48144", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine = ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5602295", "l": "CYP4F22 20-hydroxylates TrXA3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74425", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + H(+)(in) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57287", "l": "a guanosine in RNA + methylglyoxal <=> an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71670", "l": "PKM dephosphorylates PEP to PYR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63617", "l": "prunetin + UDP-alpha-D-glucuronate => H(+) + prunetin-C(8)-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68222", "l": "(7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA => (7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429730", "l": "PPM1L dephosphorylates multiphospho-CERT1-2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.5.2", "l": "\"small monomeric GTPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-742373", "l": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987129", "l": "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30623", "l": "A + all-trans-neurosporene = AH2 + all-trans-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190260", "l": "FGFR2b binds to FGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-199910", "l": "MSK1 activates ATF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65525", "l": "9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase] => 9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011346", "l": "MSI1 binds ROBO3.1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61787", "l": "L-allulose <=> keto-L-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672978", "l": "RAF phosphorylates MAP2K dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938300", "l": "Vanin hydrolyses pantetheine to PanK, 2AET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1247960", "l": "Activation of p38 MAPK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682769", "l": "LGI2 binds ADAM22,23 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46584", "l": "1alpha-hydroxyvitamin D2 + O2 + reduced [NADPH--hemoprotein reductase] = 1alpha,25-dihydroxyvitamin D2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54531", "l": "aldehydo-D-ribose 5-phosphate <=> D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202966", "l": "Caspase mediated cleavage of HIP-55 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49313", "l": "2-trans,4-trans-xanthoxin + NAD(+) => 2-trans-(+)-abscisic aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013158", "l": "CDC42 GDIs block activation of CDC42 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36541", "l": "CoA + H(+) + N-hexadecanoylsphinganine => hexadecanoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54395", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35484", "l": "5alpha-cholest-7-en-3-one + S-adenosyl-L-methionine => 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-182988", "l": "Sprouty lures CBL away from EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19251", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate + glycine => glyoxylate + L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45818", "l": "AH2 + pyruvate => (S)-lactate + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78259", "l": "D-proline + O2 = 1-pyrroline-2-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44076", "l": "ATP + CoA + pentadecanoate = AMP + diphosphate + pentadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71642", "l": "K(+)(in) + Na(+)(in) <=> K(+)(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18454", "l": "[(1->2)-beta-D-glucosyl](n)(in) + ATP + H2O => [(1->2)-beta-D-glucosyl](n)(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27699", "l": "GDP-beta-L-galactose + phosphate => beta-L-galactose 1-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046848", "l": "hydroxyapatite binding", "d": ["Binding to hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67685", "l": "a long-chain fatty acid(in) + ATP + H2O => a long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.102", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399711", "l": "Activation of Ca impermeable AMPA receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015284", "l": "fructose uniporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in)."], "t": []}, {"i": "RHEA:60372", "l": "D-fructose(out) = D-fructose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29971", "l": "2'-deoxyinosine(in) + H(+)(in) = 2'-deoxyinosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9726580", "l": "PGR binds PGR agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45070", "l": "CoA + O-acyl-(R)-carnitine => (R)-carnitine + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9748999", "l": "NME1:2 hexamer phosphorylates 6TGDP to 6TGTP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949413", "l": "HTMLYS translocates from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75165", "l": "H(+) + NADP(+) + UDP => NAD(+) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9824280", "l": "MSGN1 binds the DLL3 gene in presomitic mesoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42332", "l": "ATP + L-glutamate + oxidized coenzyme F420-2 = ADP + H(+) + oxidized coenzyme alpha-F420-3 + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.32", "l": "\"coenzyme gamma-F420-2:alpha-L-glutamate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33015", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 = [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.160", "l": "\"(2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754839", "l": "SARS-CoV-2 9b binds IKBKG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62616", "l": "a lactoside III(4)-a-Fuc-Lc4Cer + GDP-beta-L-fucose = a lactoside IV(2),III(4)-a-[Fuc]2-Lc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57296", "l": "an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25874", "l": "H2O + pyridine N-oxide => H2O2 + pyridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9824888", "l": "OPTN, TBK1 bind ubiquitinated MOM proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38403", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + 1,3-di-(9Z,12Z)-octadecadienoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693564", "l": "Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174447", "l": "RFC dissociates after sliding clamp formation on the C-strand of the telomere (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67108", "l": "L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(37)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40955", "l": "(R)-5-phosphomevalonate + ATP = ADP + CO2 + isopentenyl phosphate + phosphate", "d": [], "t": []}, {"i": "EC:4.1.1.99", "l": "\"phosphomevalonate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43746", "l": "AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2) => ATP + cytidine(34) in tRNA(Ile2) + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39623", "l": "3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21435", "l": "(S)-malate + NAD(+) <=> H(+) + NADH + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63260", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H(+) + NADH = 4-pyridoxate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3343700", "l": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15144", "l": "4-methylphenol + H2O + 4 oxidized [azurin] <=> 4-hydroxybenzaldehyde + 4 H(+) + 4 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2393954", "l": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.25", "l": "\"bacteriophage T4 restriction endoribonuclease RegB\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39261", "l": "(2E,13Z)-docosadienoyl-CoA + H2O => (3R)-hydroxy-(13Z)-docosenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1181149", "l": "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.n3", "l": "\"ISG15--protein ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047693", "l": "ATP diphosphatase activity", "d": ["Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44109", "l": "H2O + heptanal + NAD(+) => 2 H(+) + heptanoate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68610", "l": "Formation of ORC(2-5) complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.181590755138103", "identifiers": [{"i": "GO:0008047", "l": "enzyme activator activity", "d": ["Binds to and increases the activity of an enzyme."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13420", "l": "5,12-dihydroxanthommatin + NAD(+) <=> H(+) + NADH + xanthommatin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77169", "l": "2-acetamidoglucal + A + H2O + selenoneine => AH2 + hercynyl-SeGlcNAc selenoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71549", "l": "5-N(alpha)-glycyl-dTMP in DNA + phosphate => 5-phosphomethyl-dUMP in DNA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170158", "l": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160892", "l": "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61737", "l": "steviolmonoside + UDP-alpha-D-glucose => rubusoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0019172", "l": "glyoxalase III activity", "d": ["Catalysis of the reaction: methylglyoxal + H2O = D-lactate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-392263", "l": "AVP(20-28) binds AVPR2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53975", "l": "(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O <=> (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295540", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57378", "l": "(S)-1-hydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39254", "l": "(2E,11Z)-eicosadienoyl-CoA + H(+) + NADPH <=> (11Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685011", "l": "ATR activation at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50568", "l": "acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709109", "l": "DHFR dimer binds DHFR inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800149", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306963", "l": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781840", "l": "ERCC6 binds stalled RNA Pol II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.74", "l": "\"cutinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47166", "l": "CO2 + NADH + zymosterone => 4alpha-carboxyzymosterol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21413", "l": "NAD(+) + sn-glycerol 1-phosphate => dihydroxyacetone phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22946", "l": "5beta-pregnan-3,20-dione + H(+) + NADPH => 3beta-hydroxy-5beta-pregnane-20-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202726", "l": "F11R dimerises (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.25", "l": "\"branched-chain alpha-keto acid dehydrogenase system\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42665", "l": "alpha-L-arabinopyanose + NADP(+) => H(+) + L-arabinono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69988", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + NADP(+) => (22S)-22-hydroxycampest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55880", "l": "apo-[aequorin]--coelenterazine + O2 = [aequorin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71862", "l": "glycochenodeoxycholate(out) <=> glycochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140855", "l": "histone H3S57 kinase activity", "d": ["Catalysis of the reaction: histone H3-serine (position 57) + ATP = histone H3-phosphoserine (position 57) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 57 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59561", "l": "H2O + N,N',N''-triacetylchitotriono-1,5-lactone => H(+) + N,N',N''-triacetylchitotrionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363306", "l": "p130 (RBL2) binds Cyclin E/A:CDK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158942", "l": "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38329", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.35", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692781", "l": "p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49809", "l": "a quinone + butan-1-ol => a quinol + butanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62252", "l": "2 hydrogencarbonate(out) + Zn(2+)(out) = 2 hydrogencarbonate(in) + Zn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76112", "l": "4-methylumbelliferone beta-D-glucuronate + H2O => 4-methylumbelliferone + D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-912734", "l": "CBL:CRKL binds RAPGEF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420688", "l": "GABAB heterodimeric receptor binds GABA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66784", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(out) = 6-phospho-N-acetyl-beta-D-muramate-(1->4)-N-acetyl-D-glucosamine(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-936952", "l": "Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-429845", "l": "5' to 3' exoribonuclease hydrolyzes decapped mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41001", "l": "1-tetradecanoyl-sn-glycerol + H(+) + phosphocholine => 1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39768", "l": "20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-oxo-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800299", "l": "HGFAC cleaves pro-HGF to form HGF dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6781899", "l": "USP13 binds SIAH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418858", "l": "RhoGTPase GEF's recruited to DCC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2393939", "l": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13434", "l": "2'-deoxycytidine + H(+) + H2O => 2'-deoxyuridine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164834", "l": "Enzyme-bound ATP is released (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16309", "l": "H2O + taurochenodeoxycholate = chenodeoxycholate + taurine", "d": [], "t": []}, {"i": "EC:3.5.1.74", "l": "\"chenodeoxycholoyltaurine hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404142", "l": "atROL binds RBP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58124", "l": "(19E)-geissoschizine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + polyneuridine aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5689973", "l": "USP10,USP24,USP42 deubiquitinate TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015044", "l": "rubredoxin-NAD+ reductase activity", "d": ["Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047398", "l": "dolichylphosphate-mannose phosphodiesterase activity", "d": ["Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40375", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029476", "l": "Role of myosins in phagosome formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49224", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + reduced [flavodoxin] = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60274", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975147", "l": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-982810", "l": "JAK2 phosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33850", "l": "H2O + N-tetracosanoyl-(4R)-hydroxysphinganine <=> (4R)-hydroxysphinganine + tetracosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851092", "l": "NPM1-ALK and FOXM1-dependent CCNB1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51867", "l": "(2E)-geranyl diphosphate + esculetin <=> 8-geranylesculetin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16686", "l": "di-trans,poly-cis-dolichol + hexadecanoyl-CoA => a dolichyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868709", "l": "Maltose is converted to trehalose (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70870", "l": "ECHS1 hydrates methacrylyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034282", "l": "ent-pimara-8(14),15-diene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429441", "l": "SYK activation by SRC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10188", "l": "acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.10", "l": "\"hydroxymethylglutaryl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48553", "l": "1-(9S,13S-12-oxo-10,15Z-phytodienoyl)-2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O => (9S,13S,15Z)-12-oxophyto-10-15-dienoate + 2-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20835", "l": "ATP + guanine(out) + H2O <=> ADP + guanine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28994", "l": "N-acetylneuraminate(in) <=> N-acetylneuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023538", "l": "MECP2 binds PTPN1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9670101", "l": "ATRX:DAXX binds to subtelomeric chromosomal regions (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.14", "l": "\"asparagine--oxo-acid transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39303", "l": "(3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA = (2E,11Z,14Z)-eicosatrienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55346", "l": "1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624112", "l": "CEBPA binds CDK4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449811", "l": "IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42899", "l": "L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9840401", "l": "DELE1(143-515) is released into the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.112", "l": "\"indanol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59761", "l": "apigenin + UDP-alpha-D-glucose => apigenin 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45872", "l": "15-hydroxypentadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(14-hydroxytetradecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30915", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = a fatty acid + beta-D-glucosyl-(1<->1)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24005", "l": "butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72241", "l": "estrone 3-sulfate(in) + L-glutamate(out) => estrone 3-sulfate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050002", "l": "D-proline reductase activity", "d": ["Catalysis of the reaction: 5-aminopentanoate + [PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine = [PrdC protein]-L-selenocysteine/L-cysteine + D-proline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730872", "l": "Activation of Calcineurin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39686", "l": "3-oxo-(11Z)-octadecenoyl-CoA + H(+) + NADPH <=> (R)-3-hydroxy-(11Z)-octadecenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448708", "l": "IL24 binds to IL22RA1:JAK1:IL20RB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59256", "l": "Fe(III)-enterobactin + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700120", "l": "PTN and MDK bind to PTPRZ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025152", "l": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5672965", "l": "RAS GEFs promote RAS nucleotide exchange (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23745", "l": "2-oxoglutarate + L-histidinol phosphate => 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050575", "l": "2-(S)-hydroxypropyl-CoM dehydrogenase activity", "d": ["Catalysis of the reaction: 2-(S)-hydroxypropyl-coenzyme M + NAD+ = 2-oxopropyl-coenzyme M + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4093327", "l": "EPHA binds TIAM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9859163", "l": "DBT transfers BCAA to CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19243", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15374", "l": "columbamine + S-adenosyl-L-methionine => H(+) + palmatine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47748", "l": "a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+)", "d": [], "t": []}, {"i": "EC:7.2.1.1", "l": "\"NADH:ubiquinone reductase (Na(+)-transporting)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53785", "l": "beta-muricholate + deoxycholoyl-CoA => beta-muricholoyl-CoA + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395517", "l": "NADPH transfers electrons to FDXR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14690", "l": "4-chlorophenylacetate + NADH + O2 => 3,4-dihydroxyphenylacetate + chloride + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58911", "l": "7 (S)-methylmalonyl-CoA + 21 H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH <=> C37-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 7 CO2 + 7 CoA + 7 H2O + 14 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50157", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 => N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047285", "l": "flavonol-3-O-glycoside xylosyltransferase activity", "d": ["Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30058", "l": "L-allo-threonine + NADP(+) <=> (2S)-2-amino-3-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59272", "l": "L-cysteine = D-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41410", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine => 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74267", "l": "n H(+)(out) + spermidine(in) = n H(+)(in) + spermidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446322", "l": "PARVA associates with Paxillin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668543", "l": "TRAF3:NIK binds TRAF2:cIAP1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676917", "l": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482828", "l": "PE is hydrolyzed to 2-acyl LPE by PLA2[4] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9762096", "l": "Ub,pS335,S338,T NFE2L2 is degraded (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42635", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 8-methyladenosine(2503) in 23S rRNA + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-167408", "l": "The high affinity receptor complex binds to G-protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69019", "l": "Mcm4,6,7 trimer forms and associates with the replication fork (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61994", "l": "H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0009036", "l": "type II site-specific deoxyribonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33750", "l": "a 1-acyl-sn-glycerol + ATP <=> a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046363", "l": "FGFR4 kinase mutants are inhibited by PD170734 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16618", "l": "beta-D-glucosyl-(1->3)-D-glucose + phosphate => alpha-D-glucose 1-phosphate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77833", "l": "2-dehydro-D-glucose + H2O2 + L-glutamate => H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-glutamate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66145", "l": "5-methoxytryptamine + acetyl-CoA => CoA + H(+) + melatonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947535", "l": "Cyclisation of GTP to precursor Z (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13771", "l": "dihydroxyacetone + H(+) + NADH => glycerol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12637", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.50", "l": "\"procollagen galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36198", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9676257", "l": "Formation of the SET1A complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54387", "l": "a 3-oxo-5alpha-steroid + NADP(+) <=> a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390438", "l": "FAR2 reduces PalmCoA to HXOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33031", "l": "H(+) + keto-D-fructose + NADH = D-sorbitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70694", "l": "chloride(out) + glycine(out) + 2 Na(+)(out) <=> chloride(in) + glycine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754830", "l": "TLR8 dimer binds SARS-CoV-2 GU-rich ssRNA  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030269", "l": "tetrahydromethanopterin S-methyltransferase activity", "d": ["Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9008696", "l": "IL37(?-218) translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47119", "l": "eicosanoate + glycine <=> H2O + N-eicosanoylglycinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20703", "l": "ATP + lipid A disaccharide (E. coli) <=> ADP + H(+) + lipid IVA (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44237", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1793207", "l": "ARSB hydrolyses C4S/C6S chains (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19717", "l": "H(+) + L-phenylalanine = 2-phenylethylamine + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.53", "l": "\"phenylalanine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18238", "l": "2,5-dihydroxybenzoate + O2 => 3-maleylpyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55589", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base => a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989747", "l": "Expression of FHL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106615", "l": "Removal of siRNA passenger strand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51373", "l": "(9Z)-hexadecenoyl-CoA + glycine => CoA + H(+) + N-(9Z-hexadecenoyl)-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6795290", "l": "TORC2 complex phosphorylates SGK1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193691", "l": "NF-kB migrates to the nucleus and turns on transcription (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38840", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine => 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981534", "l": "Nephrin dimer:KIRREL binds FYN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786124", "l": "STAT3,STAT6 bind p-Y-IL4R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018506", "l": "maleylacetate reductase activity", "d": ["Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5691431", "l": "PSMD14 cleaves K63-linked ubiquitin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21368", "l": "H2O + O2 + urate = 5-hydroxyisourate + H2O2", "d": [], "t": []}, {"i": "EC:1.7.3.3", "l": "\"factor independent urate hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.178", "l": "\"methylxanthine N(1)-demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72136", "l": "putrescine(out) => putrescine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39945", "l": "a 1,2-diacylglycerol + CoA => a 1-acylglycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371422", "l": "ATP hydrolysis by HSP70 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112033", "l": "PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19780", "l": "A + L-pipecolate <=> AH2 + H(+) + L-1-piperideine-6-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62679", "l": "10-formyldihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-thiocarboxamide <=> 6-thio-IMP + 7,8-dihydrofolate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-197958", "l": "FPGS-2 transforms THF to THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64344", "l": "4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + H(+) + NADPH + O2 = 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45411", "l": "(2E)-dodecenoyl-CoA + H(+) + NADH <=> dodecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31628", "l": "10-deoxymethynolide + dTDP-alpha-D-desosamine => 10-deoxymethymycin + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62145", "l": "dGMP + dGTP => 2 dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204773", "l": "Interaction of Tie2 and Grb7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5173005", "l": "B3GALTL transfers glucose to O-fucosyl-proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60719", "l": "(1R,3R)-chrysanthemal + H2O + NADP(+) <=> (1R,3R)-chrysanthemate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72603", "l": "(E)-sinapate + ATP + H(+) = (E)-sinapoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36389", "l": "6''-O-carbamoylkanamycin A + AMP + H(+) => carbamoyl adenylate + kanamycin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73455", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + salvigenin = 8-hydroxysalvigenin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34410", "l": "3 ATP <=> 5'-triphosphoadenylyl-(2'->5')-adenylyl-(2'->5')-adenosine + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-374909", "l": "Catabolism of Noradrenaline (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851122", "l": "p-Y705,S727 STAT3 dimer binds NOTCH gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592234", "l": "Expression of GABPA (NRF2 alpha subunit) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018723", "l": "3-phenanthrol sulfotransferase activity", "d": ["Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34812", "l": "NADP(+) + tetrahydrocurcumin => dihydrocurcumin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58782", "l": "a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine => a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74114", "l": "H(+) + hypotaurine + NADH + O2 <=> H2O + NAD(+) + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35692", "l": "(2S)-versicolorone + NADP(+) => 1'-hydroxyversicolorone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161999", "l": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050356", "l": "tropine dehydrogenase activity", "d": ["Catalysis of the reaction: NADP+ + tropine = H+ + NADPH + tropinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53925", "l": "a secondary amine + S-adenosyl-L-methionine => a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29165", "l": "2 H2O(out) + 3 menaquinone-8(in) + NH4(+)(out) => 2 H(+)(out) + 3 menaquinol-8(in) + nitrite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0008187", "l": "poly-pyrimidine tract binding", "d": ["Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37619", "l": "(9Z)-octadecenoyl-CoA + 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868658", "l": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48705", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70716", "l": "glycine(in) => glycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76159", "l": "fluoride(in) = fluoride(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050446", "l": "azobenzene reductase activity", "d": ["Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047645", "l": "alkan-1-ol dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72120", "l": "(R)-carnitine(in) + glycine betaine(out) => (R)-carnitine(out) + glycine betaine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9844006", "l": "SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.262", "l": "\"soyasapogenol glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16365", "l": "digallate + H2O = 2 3,4,5-trihydroxybenzoate + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.20", "l": "\"tannase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.98", "l": "\"glucan 1,4-alpha-maltohexaosidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042654", "l": "ecdysis-triggering hormone receptor activity", "d": ["Combining with ecdysis-triggering hormone to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57356", "l": "2-oxoglutarate + chloride + H(+) + hapalindole U + O2 = CO2 + H2O + hapalindole G + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52037", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate => L-isoleucine + tuberonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423694", "l": "AFBDHD hydrolyses non-enzymatically to AFBDHO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10674", "l": "a thymidine dimer in DNA => cyclobutadithymidine in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74220", "l": "(d)AMP + ATP <=> (d)ADP + ADP (AK1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9838289", "l": "CLPXP degrades mitochondrial matrix proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619214", "l": "CaMKK binds activated calmodulin in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12448", "l": "(R)-pantothenate + H2O = (R)-pantoate + beta-alanine", "d": [], "t": []}, {"i": "EC:3.5.1.22", "l": "\"pantothenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-194079", "l": "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-888592", "l": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67598", "l": "CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine => heptadecasphing-4-enine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-77071", "l": "Phosphorylation (Ser5) of RNA pol II CTD (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141341", "l": "SMOX-3 oxidises SPN to SPM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23132", "l": "3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite", "d": [], "t": []}, {"i": "EC:1.8.7.1", "l": "\"assimilatory sulfite reductase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63681", "l": "(7R,8S)-7,8-diammoniononanoate + CO2 => (7R,8S)-8-amino-7-(carboxyamino)nonanoate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30610", "l": "A + all-trans-phytofluene <=> AH2 + all-trans-zeta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50278", "l": "(12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate => (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21878", "l": "(S)-usnate + 2 H(+) + NADH => (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17344", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) <=> 1-hexadecanoylglycerone 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59001", "l": "H2O + O2 + propanal => H(+) + H2O2 + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449958", "l": "IL7:IL7R:JAK1 binds IL2RG:JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57765", "l": "2,6-dinitrotoluene + NADH + O2 => 3-methyl-4-nitrocatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27930", "l": "(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.2.36", "l": "\"4-phosphopantoate--beta-alanine ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687107", "l": "MAPK4,6 translocate to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9748969", "l": "NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14161", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.13.11.53", "l": "\"acireductone dioxygenase (Ni(2+)-requiring)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17906", "l": "(R)-glycerate + NAD(+) => 3-hydroxypyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1614645", "l": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18270", "l": "ethyl (S)-3-hydroxyhexanoate + NADP(+) => ethyl 3-oxohexanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856951", "l": "PP2A demethylation by PPME1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72254", "l": "(R)-adrenaline + S-adenosyl-L-methionine <=> (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64529", "l": "AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine => 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58150", "l": "acetate + ethanol + H(+) => ethyl acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70548", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose => 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49935", "l": "(3E,5Z)-octadienoyl-CoA <=> (2E,5Z)-octadienoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005122", "l": "torso binding", "d": ["Binding to a torso (tor) protein, a receptor tyrosine kinase."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018627", "l": "2-aminobenzenesulfonate 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H+ + NADH + O2 = 2,3-dihydroxybenzenesulfonate + NAD+ + NH4. 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724745", "l": "PLG(20-810) binds aprotinin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16580", "l": "ADP + ATP + H(+) <=> P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77304", "l": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13085", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O = CoA + L-2-acetamido-6-oxoheptanedioate", "d": [], "t": []}, {"i": "EC:2.3.1.89", "l": "\"tetrahydrodipicolinate N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48120", "l": "a ganglioside GD3 + H2O = a ganglioside GM3 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3296301", "l": "CCRL2 binds CCL19 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64185", "l": "H2O + N-(9Z-octadecenoyl)-L-tyrosine => (9Z)-octadecenoate + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755413", "l": "SARS-CoV-2 8 binds IL17RA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848250", "l": "ACBD6 binds LCFA-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.104", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443418", "l": "GP1b signaling involves c-Src (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3204311", "l": "AOX1 oxidises PXL to PDXate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139908", "l": "Phosphorylation of DLC2 by MAPK8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63380", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23502", "l": "3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174438", "l": "Formation of the Flap Intermediate on the C-strand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31991", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + sesquithujene", "d": [], "t": []}, {"i": "EC:4.2.3.102", "l": "\"sesquithujene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59032", "l": "(Z)-24-ethylidenelophenol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-stigmasta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47401", "l": "3-oxo-(9Z-octadecenoyl)-CoA + CoA => (7Z)-hexadecenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42915", "l": "cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1962) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35113", "l": "2,5-didehydro-D-gluconate + H(+) + NADPH => 2-dehydro-L-idonate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36688", "l": "hexadecanoyl-CoA + sphing-4-enine => CoA + H(+) + N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66740", "l": "ATP + H2O + N-acetyl-L-glutamate(in) = ADP + H(+) + N-acetyl-L-glutamate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24515", "l": "L-serine + pyrazole <=> 3-(pyrazol-1-yl)-L-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.225", "l": "\"F-actin monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53306", "l": "A + 2 adenosylcob(III)alamin + 2 H(+) + 2 triphosphate => AH2 + 2 ATP + 2 cob(II)alamin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22837", "l": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] => a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36147", "l": "acetyl-CoA + benzyl alcohol = benzyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52102", "l": "(9Z)-octadecenoate + 5-hydroxy-octadecanoate + H(+) => 5-(9Z-octadecenoyloxy)-octadecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084912", "l": "Arresten binds integrin alpha1beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114553", "l": "Activation of conventional Protein Kinase C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805205", "l": "GPR35 binds kynurenic acid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805730", "l": "SETD9 methylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52234", "l": "3 A + Fe(2+) + 3 H2O + mycobilin a => 3 AH2 + 2 H(+) + heme b + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2473184", "l": "Follistatin (FST) binds Activin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2730872", "l": "Activation of Calcineurin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63506", "l": "13-dihydrodaunorubicin + NADP(+) => daunorubicin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59281", "l": "L-asparagine => D-asparagine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76141", "l": "D-gluconate(out) => D-gluconate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14231", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174441", "l": "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2247513", "l": "STAB1:ligand is endocytosed (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70706", "l": "D-cycloserine(in) + H(+)(in) <=> D-cycloserine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23994", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA => 1-O-alkyl-sn-glycero-3-phosphocholine + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109530", "l": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6811427", "l": "COPI vesicle uncoating at the ER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016169", "l": "bacteriochlorophyll c binding", "d": ["Binding to bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034880", "l": "citrazinate dehydrogenase activity", "d": ["Catalysis of the reaction: citrazinate + H2O = 2,3,6-trihydroxyisonicotinate + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2529020", "l": "CK2 phosphorylates condensin I subunits (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5688786", "l": "ATXN3 binds RAD23 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400037", "l": "Gi,Go Heterotrimeric G-protein complex dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65755", "l": "2-oxoglutarate + L-glutamate + O2 <=> (3R)-3-hydroxy-L-glutamate + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20927", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine <=> a [peptide]-C-terminal amide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0016890", "l": "site-specific endodeoxyribonuclease activity, specific for altered base", "d": ["Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks."], "t": []}, {"i": "EC:3.1.25.-", "l": "\"Site-specific endodeoxyribonucleases specific for altered bases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64744", "l": "H2O + S-3-(hexan-1-ol)-L-cysteine = 3-sulfanyl-1-hexanol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13673", "l": "[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.59", "l": "\"[protein-PII] uridylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938053", "l": "RUNX1:CBFB binds the SERPINB13 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0048031", "l": "trisaccharide binding", "d": ["Binding to a trisaccharide. Trisaccharides are sugars composed of three monosaccharide units."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209973", "l": "Tyrosine is diiodinated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-195275", "l": "Phosphorylation of APC component of the destruction complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854759", "l": "TBC1D14 binds RAB11 and ULK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12206", "l": "3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9689680", "l": "IFNG dimer binds IFNG inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29501", "l": "(+)-alpha-barbatene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58365", "l": "a medium-chain primary fatty alcohol + NADP(+) => a medium-chain fatty aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45864", "l": "16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21004", "l": "(R)-pantolactone + A = 2-dehydropantolactone + AH2", "d": [], "t": []}, {"i": "EC:1.1.99.27", "l": "\"(R)-pantolactone dehydrogenase (flavin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26403", "l": "(2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone => all-trans-10'-apo-beta-carotenal + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70606", "l": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421452", "l": "2 protoporphyrinogen IX + 3 O2 => 2 protoporphyrin IX + 6 H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39352", "l": "(3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA => (2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102610", "l": "(+)-secoisolariciresinol glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-secoisolariciresinol + UDP-alpha-D-glucose = (+)-secoisolariciresinol monoglucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70938", "l": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59418", "l": "H2O2 + indole-3-acetaldehyde + NH4(+) => H2O + O2 + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8936584", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20725", "l": "a 4-saturated-(3S)-3-hydroxyacyl-CoA => a (3E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420591", "l": "Nectin-2:Nectin 3 trans heterodimer interaction (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32150", "l": "H2O + sepiapterin <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700137", "l": "ALK:MDK dimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047596", "l": "6-methylsalicylate decarboxylase activity", "d": ["Catalysis of the reaction: 6-methylsalicylate + H+ = 3-cresol + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5617037", "l": "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77077", "l": "Capping complex formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684006", "l": "KPNA2 translocates NBN to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851842", "l": "MUC20 binds MET and inhibits GRB2 binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166538", "l": "The bound receptor dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182594", "l": "Association of INK4 family proteins with CDK4/6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757256", "l": "MCM3 binds MCM5 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13154", "l": "(R)-glycerate + CO2 + NAD(+) => 2-hydroxy-3-oxosuccinate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48559", "l": "4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) <=> 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41077", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27647", "l": "inosine + phosphate => alpha-D-ribose 1-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019237", "l": "centromeric DNA binding", "d": ["Binding to a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189062", "l": "lactose + H2O => D-glucose + D-galactose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2855252", "l": "AKRs reduce RBP2:atRAL to RBP2:atROL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047238", "l": "glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52176", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 14,15-epoxy-(5Z,8Z,11Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050191", "l": "phosphoglycerate kinase (GTP) activity", "d": ["Catalysis of the reaction: 3-phospho-D-glycerate + GTP = 3-phospho-D-glyceroyl phosphate + GDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193787", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952419", "l": "SMURFs ubiquitinate RUNX3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654510", "l": "FGFRL1 binds SPRED1/2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37852", "l": "13-deoxydaunorubicin + H(+) + NADPH + O2 => 13-dihydrodaunorubicin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56506", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25860", "l": "GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + diphosphate + formate + H(+)", "d": [], "t": []}, {"i": "EC:3.5.4.39", "l": "\"GTP cyclohydrolase IV\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032768", "l": "Translocation of WWTR1 (TAZ) to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63954", "l": "a sphingoid base + phosphate => a sphingoid 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73544", "l": "dCDP(out) + UTP(in) => dCDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28260", "l": "cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + H(+) + UDP => cyanidin 3-O-beta-D-glucoside + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77998", "l": "9-hydroxy-octadecanoate + a 1,2-diacyl-sn-glycerol <=> 9-(acyloxy)-octadecanoate + a 2-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69698", "l": "H(+) + menadione + NADH <=> menadiol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193054", "l": "Oxidation of cholesterol to 22beta-hydroxycholesterol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003992", "l": "N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8869568", "l": "NPM1 binds TFAP2A homodimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202722", "l": "CD48 binds CD244 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046981", "l": "beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202168", "l": "Phosphorylation of ZAP-70 by Lck (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3266557", "l": "Factor I cleaves iC3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65973", "l": "a peptide antigen(in) + ATP + H2O => a peptide antigen(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68868", "l": "ATP + benzoate + H(+) + NADPH = AMP + benzaldehyde + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58024", "l": "oleanolate + UDP-alpha-D-glucose = H(+) + oleanolate 3-O-beta-D-glucoside + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.368", "l": "\"oleanolate 3-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51667", "l": "D-5-phenylhydantoin + H2O <=> H(+) + N-carbamoyl-D-phenylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28137", "l": "(2S)-hesperidin + H2O <=> (2S)-hesperetin + rutinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849055", "l": "PTK6 binds ARHGAP35 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.58", "l": "\"russellysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50815", "l": "androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.616479785166973", "identifiers": [{"i": "GO:0001217", "l": "DNA-binding transcription repressor activity", "d": ["A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14217", "l": "[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823958", "l": "EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8981621", "l": "Neuroglobin:oxygen dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448963", "l": "Interaction of MyoD:E protein with MEF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13973", "l": "diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate", "d": [], "t": []}, {"i": "EC:7.1.3.1", "l": "\"H(+)-exporting diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34740", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphocholine => H(+) + N-acyl-15-methylhexadecasphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3266557", "l": "Factor I cleaves iC3b (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-156913", "l": "Regeneration of eEF1A:GTP by eEF1B activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2032775", "l": "YAP1 binds TEAD1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51514", "l": "NH4(+) + oxalate => H2O + oxamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.341", "l": "\"vanillate/3-O-methylgallate O-demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57705", "l": "(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) => 3-(3,4-dihydroxyphenyl)pyruvate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2467798", "l": "PTTG1 (Securin) sequesters ESPL1 (Separase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61367", "l": "ATP + dehydroepiandrosterone 3-sulfate(in) + H2O <=> ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29380", "l": "dGMP + H2O => 2'-deoxyguanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8870489", "l": "PLEKHA4,(5,6) bind PI3P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797955", "l": "ALDH7A1 oxidises BETALD to BET (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59178", "l": "AMP + H(+) + O-phospho-L-serine => ADP + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34666", "l": "20-methyl-21,22-didehydro-20,21-dihydrobotryococcene + S-adenosyl-L-methionine <=> 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42922", "l": "H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + uridine(1498) in 16S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951727", "l": "cAMP binds PKA tetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8874206", "l": "MBTPS1 (S1P) cleaves CREB3L3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177935", "l": "SHP2 dephosphorylates Tyr 992 on EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244397", "l": "botB HC:LC binds SYT1 or 2 and GT1b on the target cell surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033947", "l": "mannosylglycoprotein endo-beta-mannosidase activity", "d": ["Catalysis of the hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequences."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809003", "l": "ERGIC-to-Golgi vesicles bind dynein:dynactin  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949688", "l": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102140", "l": "heparan sulfate N-deacetylase activity", "d": ["Catalysis of the reaction: H2O + [heparan sulfate]-N-acetyl-alpha-D-glucosamine = acetate + H+ + [heparan sulfate]-alpha-D-glucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29297", "l": "aldehydo-D-galacturonate(in) + H(+)(in) => aldehydo-D-galacturonate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004740", "l": "pyruvate dehydrogenase (acetyl-transferring) kinase activity", "d": ["Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50449", "l": "AH2 + prostaglandin G3 => A + H2O + prostaglandin H3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690046", "l": "PPT2 hydrolyses PALMCoA to PALM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849350", "l": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193393", "l": "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16955", "l": "L-glutamate + N-succinyl-L-glutamate 5-semialdehyde => 2-oxoglutarate + N(2)-succinyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731047", "l": "SARS-CoV-1 6 binds to NMI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5652009", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848110", "l": "SOCS3 binds activated PTK6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41099", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64454", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357828", "l": "RIPK1 is cleaved by CASP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75805", "l": "butanoate(in) + Na(+)(in) => butanoate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9712210", "l": "odorant binds Odorant Receptor:GNAL:GDP:GNB1:GNGT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641111", "l": "Parkin transfers Ub to misfolded proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49961", "l": "(1R)-1,4,5,10-tetrahydrophenazine-1-carboxylate + H(+) + O2 => 5,10-dihydrophenazine + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73860", "l": "1-methylnicotinamide(out) => 1-methylnicotinamide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36664", "l": "(S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA => (2S,5S)-5-carboxymethylproline + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68956", "l": "S-adenosyl-L-methionine + scopoletin = H(+) + S-adenosyl-L-homocysteine + scoparone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39107", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37391", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-443978", "l": "Receptor CCR11 binds CCL19, CCL21 & CCL25 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265177", "l": "Exocyst complex formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017855", "l": "NICD3 binds to TACC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50890", "l": "an N-acyl-sphingoid base + phosphate => an N-acylsphingoid base 1-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050153", "l": "omega-hydroxydecanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 10-hydroxydecanoate + NAD+ = 10-oxodecanoate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951727", "l": "cAMP binds PKA tetramer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63816", "l": "ATP + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine + spermidine = AMP + diphosphate + H(+) + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41755", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15088", "l": "an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O <=> an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9859172", "l": "DLD dimer dehydrogenates dihydrolipoyl (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-192051", "l": "CYP7A1 7-hydroxylates CHOL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12243", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH <=> 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982792", "l": "Growth hormone receptor binds JAK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983150", "l": "Proteasomal cleavage of substrate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76987", "l": "an N-acylsphing-4-enine(in) = an N-acylsphing-4-enine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163820", "l": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211873", "l": "CYP4F2, 4F3 20-hydroxylate LTB4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25868", "l": "H2O + N(1),N(12)-diacetylspermine + O2 = 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16669", "l": "H2O + NAD(+) + xanthine = H(+) + NADH + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32092", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine => dTDP + erythromycin D + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022851", "l": "EXT1:EXT2 transfer GlcNAc to the heparan chain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.4.1.6", "l": "\"acetone carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548818", "l": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37921", "l": "(8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate => (9Z,12Z)-octadecadienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43090", "l": "5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine => 5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49581", "l": "(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate => cyclic pyranopterin phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31968", "l": "ent-cassa-12,15-diene + O2 + reduced [NADPH--hemoprotein reductase] => ent-11beta-hydroxycassa-12,15-diene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904769", "l": "isopentadecanoic acid binding", "d": ["Binding to isopentadecanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36548", "l": "octadecanoyl-CoA + sphinganine => CoA + H(+) + N-(octadecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044020", "l": "histone H4R3 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to the arginine residue at position 3 of histone H4, producing histone H4R3me."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043861", "l": "agmatine:putrescine antiporter activity", "d": ["Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16842", "l": "precorrin-2 + S-adenosyl-L-methionine => H(+) + precorrin-3A + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204500", "l": "CyP60 chaperones Basigin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16857", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.113", "l": "\"site-specific DNA-methyltransferase (cytosine-N(4)-specific)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.1", "l": "\"chymotrypsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139897", "l": "BAD displaces tBID from BCL-2 sequestration (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102532", "l": "genkwanin 6-hydroxylase activity", "d": ["Catalysis of the reaction: genkwanin + O2 + NADPH + H+ = scutellarein 7-methyl ether + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30968", "l": "9,9',15-tri-cis-zeta-carotene => 9,9'-di-cis-zeta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22283", "l": "O-demethylpuromycin + S-adenosyl-L-methionine <=> H(+) + puromycin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44863", "l": "(R)-carnitine + 4,8-dimethylnonanoyl-CoA <=> CoA + O-4,8-dimethylnonanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000100", "l": "S-methylmethionine transmembrane transporter activity", "d": ["Enables the transfer of S-methylmethionine from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34314", "l": "4-nitrocatechol + NADH + O2 <=> 2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140346", "l": "phosphatidylserine flippase activity", "d": ["Catalysis of the movement of phosphatidylserine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72864", "l": "3',3',3'-cAAG + H2O => G[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9845587", "l": "ST8SIA5 transfers Neu5Ac to gangliosides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.266", "l": "\"dTDP-4-dehydro-6-deoxyglucose reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672980", "l": "Dissociation of RAS:RAF complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193705", "l": "IKKbeta phosphorylates IkB causing NF-kB to dissociate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6805638", "l": "KAT6A acetylates TP53 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209925", "l": "DIT and MIT combine to form triiodothyronine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50030", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine => H2O + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12009", "l": "[G-protein-coupled receptor] + ATP => [G-protein-coupled receptor]-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174238", "l": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66792", "l": "N-methyl-D-dopa + O2 = (3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73617", "l": "CTP(in) + dCMP(out) => CTP(out) + dCMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13363", "l": "CDP-glycerol + diphosphate => CTP + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20203", "l": "AMP + D-phenylalanine + diphosphate + H(+) => ATP + H2O + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0004972", "l": "NMDA glutamate receptor activity", "d": ["An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904768", "l": "all-trans-retinol binding", "d": ["Binding to all-trans-retinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694425", "l": "NSF ATPase activity dissociates cis-SNARE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69813", "l": "6-deoxoteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46141", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (22R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37722", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29420", "l": "H(+)(out) + Na(+)(in) => H(+)(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4090281", "l": "PIAS1,2-1 SUMOylate HIC1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21821", "l": "L-homocysteine + S-adenosyl-L-methionine => H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25285", "l": "O2 + reduced [NADPH--hemoprotein reductase] + squalene <=> (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56895", "l": "H(+) + NADPH + UDP-4-dehydro-beta-L-rhamnose <=> NADP(+) + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046298", "l": "B4GALTs transfer Gal to a branch of keratan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754934", "l": "SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67025", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77589", "l": "Recognition of AAUAAA sequence by CPSF (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76966", "l": "2-hexyl-5-heptylresorcinol + O2 + reduced [NADPH--hemoprotein reductase] <=> 2-hexyl-5-(7-hydroxyheptyl)resorcinol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607751", "l": "TRAF6 oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72614", "l": "H(+)(out) + L-alanyl-L-lysine(out) <=> H(+)(in) + L-alanyl-L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42966", "l": "pseudouridine(54/55) in tRNA => uridine(54/55) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675949", "l": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41715", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O <=> a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981728", "l": "Factor H binds to membrane-associated C3b (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18254", "l": "(S)-malate + NADP(+) => CO2 + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35604", "l": "beta-D-fructose 1-phosphate + H2O => D-fructose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63377", "l": "an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70270", "l": "hydrogencarbonate(in) + Na(+)(in) <=> hydrogencarbonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9725855", "l": "NR3C2 binds NR3C2 antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-437136", "l": "SLC30A8 transports Zn2+ from cytosol to secretory granule (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35896", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34104", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => N-acetyl-alpha-D-galactosaminyl-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851632", "l": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-893593", "l": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937029", "l": "IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654679", "l": "CBL ubiquitinates FRS2 and FGFR3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852509", "l": "CL-LK binds carbohydrates on target cell surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22090", "l": "AMP + guanosine 3'-diphosphate 5'-triphosphate => ATP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12269", "l": "2-oxoglutarate + putrescine => 1-pyrroline + H2O + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73254", "l": "cirsimaritin + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42485", "l": "D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] => D-sorbitol 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8952873", "l": "MECR dimer reduces tdec2-CoA to DEC-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416683", "l": "SEMA3E binds to PLXND1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67209", "l": "H2O + melatonin => 5-methoxytryptamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0042324", "l": "orexin receptor binding", "d": ["Binding to an orexin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35349", "l": "(2E)-octadecenoyl-CoA + H2O => 3-hydroxyoctadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83586", "l": "FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-210277", "l": "Interaction of PECAM-1 and SHP-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65147", "l": "2-oxoglutarate + berkeleyone A + O2 <=> CO2 + H2O + preaustinoid A + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641111", "l": "Parkin transfers Ub to misfolded proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9635739", "l": "PTPN7 dephosphorylates p-T,Y-MAPKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70416", "l": "(3,5-dihydroxyphenyl)acetyl-CoA + H2O => (3,5-dihydroxyphenyl)acetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19866", "l": "4 H(+) + uroporphyrinogen III => 4 CO2 + coproporphyrinogen III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61488", "l": "cytidine(50) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(50) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47270", "l": "H2O + monoanhydrobacterioruberin => bacterioruberin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34946", "l": "hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) <=> arbutin 6-phosphate(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110322", "l": "Formation of Pol zeta complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56998", "l": "apulose => aldehydo-D-apiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665278", "l": "Resistant ERBB2 KD mutants do not bind AEE788 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3247843", "l": "secretion of WNT ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67768", "l": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.99.-.-", "l": "\"Other lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28612", "l": "diphosphate + H(+) + XMP => H2O + XTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982020", "l": "G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34119", "l": "3 H(+) + hexanoyl-CoA + 3 malonyl-CoA = 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.206", "l": "\"3,5,7-trioxododecanoyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68107", "l": "all-trans-zeaxanthin + O2 <=> (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62036", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166214", "l": "FA anion flip-flops to the opposite surface (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166869", "l": "TRAF6 binds MEKK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58505", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate => (3Z)-2-oxo-4-carboxy-3-hexenedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17924", "l": "D-arabinitol + NAD(+) <=> D-xylulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28700", "l": "Mn(2+)(in) => Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71735", "l": "formyl-CoA + succinate = formate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60996", "l": "H2O + L-leucine + O2 = 4-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49421", "l": "ATP + valienone => ADP + H(+) + valienone 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13162", "l": "L-threonine + NAD(+) => (2S)-2-amino-3-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694522", "l": "Inner coat assembly and cargo binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17994", "l": "ATP + beta-alanine + gamma-L-glutamyl-L-cysteine => ADP + gamma-L-glutamyl-L-cysteinyl-beta-alanine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78377", "l": "NADP(+) + sulfinamide-CoA => H(+) + NADPH + S-nitroso-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12812", "l": "4 catechol + 3 O2 <=> 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43800", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40804", "l": "3,6-anhydro-alpha-L-galactopyranose + H2O + NADP(+) => 3,6-anhydro-L-galactonate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30787", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050638", "l": "taxadien-5-alpha-ol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0047045", "l": "testosterone 17-beta-dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5684882", "l": "CHEK1 is recruited to resected DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51582", "l": "a fatty acyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => a fatty acid(out) + ATP(in) + CoA(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8850326", "l": "TCR binds self-lipid-based antigen via CD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27892", "l": "phosphate + uridine => 3'-UMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9754130", "l": "CDK4 inhibitors bind CDK4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64769", "l": "S-3-(hexan-1-ol)-L-cysteine => 2-aminoprop-2-enoate + 3-sulfanyl-1-hexanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39571", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-427527", "l": "eNoSC dimethylates histone H3 at lysine-9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350319", "l": "Caspase mediated cleavage of vimentin at IDVD (259) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0072544", "l": "L-DOPA binding", "d": ["Binding to L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32966", "l": "2-oxoglutaramate + H2O <=> 2-oxoglutarate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72950", "l": "acetate(out) + 2 Na(+)(out) <=> acetate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3295580", "l": "TRPM4,5 transport extracellular Na+ to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433957", "l": "Activation of recruited TAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18473", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP", "d": [], "t": []}, {"i": "EC:2.4.2.17", "l": "\"ATP phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.87", "l": "\"homoisocitrate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5681980", "l": "ATG12 binds ATG7 dimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187375", "l": "SMAD3 binds STUB1 (CHIP) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-351207", "l": "Spermine  => N-acetylated spermine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062061", "l": "TAP complex binding", "d": ["Binding to a TAP complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51400", "l": "octadecanoyl-CoA + serotonin = CoA + H(+) + N-octadecanoyl-serotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182859", "l": "RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52160", "l": "(E)-phenylacetaldehyde oxime = (Z)-phenylacetaldehyde oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9835121", "l": "Heparin binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.1.26", "l": "\"2,4-diaminopentanoate dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31032", "l": "2-cis-(+)-abscisate + UDP-alpha-D-glucose => beta-D-glucopyranosyl cis-(+)-abscisate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75872", "l": "Conversion of malonyl-CoA and acetyl-CoA to palmitate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35527", "l": "H(+) + N-ethylmaleimide + NADH = N-ethylsuccinimide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42187", "l": "5alpha-androstane-3beta,17beta-diol + NAD(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917841", "l": "Acidification of Tf:TfR1 containing endosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59703", "l": "D-cellopentaono-1,5-lactone + H2O <=> D-cellopentaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64469", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) => 4-methylsulfanyl-2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445700", "l": "Myosin Binds ATP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48730", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + H(+) + NADH => 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65060", "l": "NADP(+) + taurochenodeoxycholate = 7-oxotaurolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68836", "l": "(2Z,6E)-farnesyl diphosphate = (6R,7S)-himachala-9,11-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72503", "l": "glutarate(in) + prostaglandin F2alpha(out) = glutarate(out) + prostaglandin F2alpha(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26412", "l": "(R)-lactate + N-acetyl-D-glucosamine 6-phosphate => H2O + N-acetyl-D-muramate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67935", "l": "ATP + desmosterol(in) + H2O <=> ADP + desmosterol(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30418", "l": "H(+) + 2 NADPH + O2 + octadecanal <=> formate + H2O + heptadecane + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74777", "l": "7,4'-O-dimethylkaempferol + H(+) + S-adenosyl-L-homocysteine => kaempferide + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51441", "l": "(9Z,12Z,15Z)-octadecatrienoate + O2 => (11S)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13930", "l": "agmatine + H2O => putrescine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19284", "l": "(7S)-marmesin + O2 + reduced [NADPH--hemoprotein reductase] <=> acetone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + psoralen", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74172", "l": "an N-methyl carbamate ester + H(+) + H2O => an alcohol + CO2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050126", "l": "N-carbamoylputrescine amidase activity", "d": ["Catalysis of the reaction: N-carbamoylputrescine + H2O + 2 H+ = CO2 + NH4 + putrescine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31689", "l": "(9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43701", "l": "(2E,6E)-farnesoate + S-adenosyl-L-methionine => methyl (2E,6E)-farnesoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65355", "l": "7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2316434", "l": "PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55815", "l": "a bacteriochlorophyllide d + H2O + 2 S-adenosyl-L-methionine <=> 2 5'-deoxyadenosine + a bacteriochlorophyllide f + 2 H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033748", "l": "hydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: H2 + A = AH2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34132", "l": "neryl diphosphate + olivetolate => cannabinerolate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176101", "l": "Recruitment of Rad17-RFC complex to DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32927", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = a 1,2-diacyl-sn-glycerol + H(+) + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047106", "l": "4-hydroxyphenylacetaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: (4-hydroxyphenyl)acetaldehyde + H2O + NAD+ = 4-hydroxyphenylacetate + 2 H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28807", "l": "glutathione + H2O = L-cysteinylglycine + L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5668545", "l": "NIK autophosphorylates on T559 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58810", "l": "AMP + GMP + 2 H(+) => 2',3'-cGAMP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61122", "l": "2 H(+) + 2 H2O + myricetin + 2 oxidized [NADPH--hemoprotein reductase] => kaempferol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654571", "l": "Activated FGFR1 binds FRS3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69324", "l": "(Z)-4-methylsulfanylbutyl-N-(sulfonatooxy)methanimidothioate = 4-methylsulfanylbutyl isothionate + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22773", "l": "L-fuconate => 2-dehydro-3-deoxy-L-fuconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690843", "l": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17606", "l": "ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine => ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31280", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate => (2Z,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37512", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005109", "l": "frizzled binding", "d": ["Binding to a frizzled (fz) receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029468", "l": "Conversion of PA into DAG by PAP-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57962", "l": "dimethyl sulfoxide + H2O + NAD(+) => dimethyl sulfide + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2029473", "l": "Branching and elongation of mother and daughter filaments (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52666", "l": "a short-chain (2E)-enoyl-CoA + H2O => a short-chain (3S)-3-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682631", "l": "nsp13 binds DDX5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391935", "l": "DP1 receptor can bind PGD2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75566", "l": "cyathadiol + O2 + reduced [NADPH--hemoprotein reductase] <=> cyathatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180597", "l": "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36131", "l": "(indol-3-yl)acetate + S-adenosyl-L-methionine = methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.278", "l": "\"indole-3-acetate O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2132206", "l": "MASPs activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848829", "l": "CBL autoubiquitinates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12139", "l": "a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) <=> a (2E,4E)-dienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22670", "l": "H(+) + lipid A disaccharide (E. coli) + UDP => 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32988", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => a fatty acid + H(+) + sn-glycero-3-phospho-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18854", "l": "NAD(+) + tartrate => 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28278", "l": "3-sulfino-L-alanine + H2O = H(+) + L-alanine + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-194641", "l": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18040", "l": "agmatine + H2O <=> N-carbamoylputrescine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0015186", "l": "L-glutamine transmembrane transporter activity", "d": ["Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1247960", "l": "Activation of p38 MAPK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17002", "l": "amidinoproclavaminate + H2O => proclavaminate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77735", "l": "2 H2O + ITP = 2 H(+) + IMP + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850534", "l": "PDCL promotes G-protein beta 5 folding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5607721", "l": "Activation of NIK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109278", "l": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22546", "l": "a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112587", "l": "STAT1 and STAT3 dimers translocate to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008959", "l": "phosphate acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60395", "l": "Fe(III)-C-5-deoxy-beta-D-glucosyl-enterobactin + H2O <=> Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034855", "l": "Activated PCLG1 dissociates from NTRK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623513", "l": "ASAP1 stimulates GTPase activity of ARF4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004568", "l": "chitinase activity", "d": ["Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018877", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78024", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol => a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102517", "l": "oleate 12-hydroxylase activity", "d": ["Catalysis of the reaction: oleoyl-CoA + NADH + O2 + H+ = ricinoleyl-CoA + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2173318", "l": "C5a anaphylatoxin binds C5a receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-904864", "l": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15482", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O => (6S)-5,6,7,8-tetrahydrofolate + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72711", "l": "cathenamine + H(+) = 4,21-dehydrogeissoschizine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35015", "l": "riboflavin(in) = riboflavin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428515", "l": "Recruitment of SOS to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5358475", "l": "DPH6 ligates ammonium to diphthine-EEF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9859148", "l": "BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74140", "l": "petunidin + UDP-alpha-D-glucose => petunidin 3-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43378", "l": "5-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine => 5'-deoxyinosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987104", "l": "IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54967", "l": "hexadecanoyl-[ACP] + phosphate <=> hexadecanoyl phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940641", "l": "THOP1 cleaves oligopeptide fragment (8-16aa) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66514", "l": "1-acyl-2-(9Z,12Z,15Z-octadecatrienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-acyl-2-(9Z,12Z-octadecadienoyl)-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12019", "l": "(2E,6E)-farnesyl diphosphate <=> (-)-germacrene D + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14355", "l": "CO2 + L-xylulose 5-phosphate => 3-dehydro-L-gulonate 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027532", "l": "PTGS2 dimer oxidises DHA to 13-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678742", "l": "NAGLU hydrolyses Heparan sulfate chain(4) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3134962", "l": "DHX36 binds DNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62366", "l": "(Z)-2-methylureidoacrylate + FMN-N(5)-oxide + 2 H(+) => FMN-N(5)-peroxide + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052656", "l": "L-isoleucine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-432707", "l": "trans-Golgi Network Lysosomal Vesicle Scission (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49181", "l": "a bacteriochlorophyllide d + S-adenosyl-L-methionine => a bacteriochlorophyllide c + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0061507", "l": "2',3'-cyclic GMP-AMP binding", "d": ["Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015161", "l": "lipid III floppase activity", "d": ["Enables the transbilayer of capsular-polysaccharides (Und-PP-GlcNAc-ManNAcA-Fuc4NAc (lipid III)) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of ECA. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211224", "l": "Association of DFF40 with DFF45 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28704", "l": "Cu(2+)(in) => Cu(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004730", "l": "pseudouridylate synthase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + uracil = H2O + pseudouridine 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78571", "l": "docosanoyl-CoA + O2 = (2E)-docosenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174731", "l": "Degradation of newly synthesized ApoB-48 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41333", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004833", "l": "tryptophan 2,3-dioxygenase activity", "d": ["Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44222", "l": "15-hydroxypentadecanoyl-CoA + AMP + diphosphate => 15-hydroxypentadecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-112434", "l": "Formation of DSIF complex  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36527", "l": "(11Z)-eicosenoyl-CoA + H(+) + malonyl-CoA = (13Z)-3-oxodocosenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2562526", "l": "PLK1 phosphorylates OPTN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726949", "l": "PTGIR binds PTGIR agonists (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21488", "l": "dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O = beta-D-apiofuranosyl-(1->6)-D-glucopyranose + dalnigrein + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31510", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine <=> H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67327", "l": "acetyl-CoA + ATP + 11 H(+) + L-serine + 7 malonyl-CoA + 8 NADPH + 2 S-adenosyl-L-methionine <=> (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 7 CO2 + 8 CoA + diphosphate + 6 H2O + 8 NADP(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6799350", "l": "Exocytosis of specific granule membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14911", "l": "aldehydo-D-glucuronate + H(+) + NADPH => L-gulonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27855", "l": "(2E)-geranyl diphosphate + 4-hydroxybenzoate => 3-geranyl-4-hydroxybenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9842833", "l": "SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174963", "l": "NAT1 acetylation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34653", "l": "3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H(+) + S-adenosyl-L-homocysteine => 3-methyl-1,2-didehydro-2,3-dihydrosqualene + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111238", "l": "Formation of ADAR2  homodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78862", "l": "a short-chain 2,3-saturated fatty acyl-CoA + O2 <=> a short-chain (2E)-enoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41993", "l": "17beta-hydroxy-5alpha-androstan-3-one + NAD(+) => 5alpha-androstan-3,17-dione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10638", "l": "D-mannuronate + H(+) + NADPH => D-mannonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174741", "l": "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48868", "l": "H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-379395", "l": "MAOA:FAD deaminates 3MT to HVA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626816", "l": "PIN1 binds p-S345-NCF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851877", "l": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416546", "l": "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20573", "l": "calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-434650", "l": "MATEs mediate extrusion of xenobiotics (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5626220", "l": "C2CD3 binds the mother centriole (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32760", "l": "L-lysine => (3R)-3-methyl-D-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70887", "l": "L-glutamine(in) + L-serine(out) + Na(+)(out) = L-glutamine(out) + L-serine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13033", "l": "aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-phosphate", "d": [], "t": []}, {"i": "EC:5.3.1.26", "l": "\"galactose-6-phosphate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16016", "l": "ATP + glycine + tRNA(Gly) <=> AMP + diphosphate + glycyl-tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64505", "l": "AH2 + H(+) + 3 malonyl-CoA + propanoyl-CoA + 2 S-adenosyl-L-methionine => 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 3 CO2 + 4 CoA + H2O + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.111153221370472", "identifiers": [{"i": "GO:0051119", "l": "sugar transmembrane transporter activity", "d": ["Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40067", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O = 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043027", "l": "cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "d": ["Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389956", "l": "Beta-tubulin:GTP + Cofactor A ->  Beta-tubulin:GTP: Cofactor A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9702354", "l": "CALCA(83-119) binds CALCA antibodies (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56190", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35663", "l": "a 1,2-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.14", "l": "\"UMP/CMP kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679266", "l": "Beclin-1 complex translocates to the ER (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34834", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate <=> N-acyl-15-methylhexadecasphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25858", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78601", "l": "3-oxoeicosanoyl-CoA + CoA => acetyl-CoA + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990970", "l": "trans-activation response element binding", "d": ["Binding to a trans-activation response (TAR) element, a hairpin RNA structure located at the 5' end of all HIV-1 transcripts, and which is required for trans-activation of a viral promoter."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804468", "l": "PIAS1 SUMOylates SP3 with SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67216", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA = (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76949", "l": "3-methylbutan-2-one + H(+) + NADPH + NH4(+) => 3-methyl-2-aminobutane + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381727", "l": "RAP1A exchanges GDP for GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20306", "l": "4-hydroxybenzaldehyde + H2O + NAD(+) => 4-hydroxybenzoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76924", "l": "2-methylcyclopentanamine + H2O + NADP(+) => 2-methylcyclopentanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1006169", "l": "Factor H binds host cell surface markers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59169", "l": "ATP + holo-[(hydroxy)phthioceranic acid synthase] + octadecanoate => AMP + diphosphate + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975926", "l": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37212", "l": "2',3'-cyclophospho-GMP + H2O => guanosine 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68765", "l": "(R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine => 8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68008", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57150", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48381", "l": "alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635843", "l": "GLI translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21067", "l": "[protein]-disulfide + 2 glutathione <=> [protein]-dithiol + glutathione disulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48525", "l": "a ganglioside GP1c + H2O => a ganglioside GQ1c + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64395", "l": "a dipeptide(out) + H(+)(out) <=> a dipeptide(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28202", "l": "2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate = 2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.3.7.7", "l": "\"ferredoxin:protochlorophyllide reductase (ATP-dependent)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194698", "l": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390931", "l": "5-HT4, 6 and 7 receptors can bind serotonin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63646", "l": "3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+) => GDP-beta-L-fucose + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37859", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + octanoyl-CoA = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9860273", "l": "Dimerization of p-S446-IRF5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59087", "l": "2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP-alpha-D-mannose <=> 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797961", "l": "CHDH oxidises Cho to BETALD (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45031", "l": "(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022056", "l": "DSPG and CSPG translocate to the lysosome for degradation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36156", "l": "AH2 + Co(II)-factor III + S-adenosyl-L-methionine => A + Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033822", "l": "glucosyl-DNA beta-glucosyltransferase activity", "d": ["Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419428", "l": "S1PR2-5 bind S1P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-392064", "l": "G alpha (z) inhibits adenylate cyclase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8862733", "l": "CCR2, CCR3 bind CCL13 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028820", "l": "Formation of VAF (virus-activated factor) complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22265", "l": "3,5,6-trichloropyridin-2-ol + FADH2 + O2 => 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10799", "l": "albendazole + H(+) + NADPH + O2 <=> albendazole S-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16986", "l": "3-oxoadipate + NADP(+) => H(+) + maleylacetate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43995", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + NADPH + O2 <=> 16-hydroxy-(2E,6E,10E)-geranylgeraniol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58436", "l": "4-methylpentan-1-ol + NADP(+) = 4-methylpentanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44391", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA <=> 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72892", "l": "acetylcholine(out) + 2 H(+)(in) => acetylcholine(in) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990308", "l": "type-I dockerin domain binding", "d": ["Binding to a type-I dockerin domain of a protein. Type-I dockerin domain is the binding partner of type-1 cohesin domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088141", "l": "PP2A-PPP2R2A dephosphorylates FOXM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50191", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 <=> N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35717", "l": "(2S-3S)-versiconal hemiacetal + acetate + H(+) => (2S,3S)-versiconal hemiacetal acetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454689", "l": "14-3-3 Binds p-S237-TBC1D1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5621353", "l": "CLEC4D binds mycobacterial trehalose-6,6'-dimycolate (TDM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26201", "l": "ammeline + H(+) + H2O = ammelide + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351871", "l": "Caspase-mediated cleavage of Z0-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38036", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate => (4Z)-2-oxohept-4-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69720", "l": "(indol-3-yl)acetate + ATP + H(+) => (indol-3-yl)acetyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55258", "l": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37624", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) => a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24931", "l": "H2O + L-cysteine = H(+) + hydrogen sulfide + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73846", "l": "a 27-hydroxysterol + UDP-alpha-D-glucose <=> a sterol 27-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56339", "l": "ent-isokaurene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> ent-isokaurene-2beta,3beta-diol + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669024", "l": "CD70 binds CD27 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9038161", "l": "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047583", "l": "4-methyloxaloacetate esterase activity", "d": ["Catalysis of the reaction: 4-methoxy-2,4-dioxobutanoate + H2O = H+ + methanol + oxaloacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008673", "l": "2-dehydro-3-deoxygluconokinase activity", "d": ["Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35271", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199144", "l": "Nectin 2 binds CD226 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-391935", "l": "DP1 receptor can bind PGD2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9858589", "l": "DLD dimer dehydrogenates dihydrolipoyl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605632", "l": "bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29757", "l": "(R)-lipoate(out) => (R)-lipoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63027", "l": "(13Z)-docosenamide + H2O <=> (13Z)-docosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24987", "l": "(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450031", "l": "Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212710", "l": "EGFR activates PLC-gamma1 by phosphorylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426569", "l": "Interaction of DAP12 and IREM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692408", "l": "NPR2 binds NPPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62191", "l": "9alpha-copalyl diphosphate <=> diphosphate + syn-isopimara-7,15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58585", "l": "dihydroprecondylocarpine acetate => (-)-tabersonine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66193", "l": "(4Z,15Z)-bilirubin IXalpha C8,C12-beta-D-bisglucuronoside(in) + ATP + H2O => (4Z,15Z)-bilirubin IXalpha C8,C12-beta-D-bisglucuronoside(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64269", "l": "emodin anthrone + O2 => emodin + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.4.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31586", "l": "2-oxo-dATP + H2O <=> 2-oxo-dAMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4332359", "l": "Active calmodulin binds CAMK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162425", "l": "p-S295-PDE3B hydrolyses cAMP to AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33515", "l": "2 5,6-dihydroxyindole + O2 = 2 H2O + 2 indole-5,6-quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5676596", "l": "TRAF3 binds BAFFR:BAFF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371591", "l": "Trimerization of cytosolic HSF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43427", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75084", "l": "32-oxo-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase] => 4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28620", "l": "2-hydroxy-2-methylbutanenitrile + H2O + NADP(+) => 2-methylbutyronitrile + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64350", "l": "deacetylpyripyropene E => 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5444523", "l": "Formation of MSH1:PMS2 Complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047522", "l": "15-oxoprostaglandin 13-oxidase activity", "d": ["Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102395", "l": "9-cis-beta-carotene 9',10'-cleavage oxygenase activity", "d": ["Catalysis of the reaction: 9-cis-beta-carotene + O2 = 9-cis-10'-apo-beta-carotenal + beta-ionone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35714", "l": "acetate + succinyl-CoA <=> acetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47922", "l": "ganglioside GA2 (d18:1(4E)/18:0) + N-acetylneuraminate => ganglioside GM2 (d18:1(4E)/18:0) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48751", "l": "D-threitol + NAD(+) <=> D-erythrulose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694633", "l": "SARS virus buds into ERGIC lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73872", "l": "(R)-noradrenaline(out) => (R)-noradrenaline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76446", "l": "choline(out) + n Na(+)(out) <=> choline(in) + n Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49337", "l": "2,2-dihydroxyspheroidene => H2O + spheroiden-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391375", "l": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56020", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59150", "l": "AMP + diphosphate + marinoloyl-CoA C => ATP + CoA + marinolate C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11024", "l": "ATP + NH4(+) = ADP + 2 H(+) + phosphoramidate", "d": [], "t": []}, {"i": "EC:2.7.3.8", "l": "\"ammonia kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51811", "l": "(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) <=> (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65151", "l": "phloretin + UDP-alpha-D-glucose <=> H(+) + trilobatin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70593", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166538", "l": "The bound receptor dimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53424", "l": "a fatty acyl-CoA + a sphingoid base = an N-acyl-sphingoid base + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.2.1.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159194", "l": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53847", "l": "glycochenodeoxycholate + NAD(+) <=> 7-oxoglycolithocholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373813", "l": "Receptor CXCR2 binds ligands CXCL1 to 7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102537", "l": "ecdysone-phosphate phosphatase activity", "d": ["Catalysis of the reaction: ecdysone 22-phosphate + H2O = ecdysone + hydrogenphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864936", "l": "VEGFA gene expression is inhibited by the TFAP2A homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102669", "l": "isoflavone-7-O-glucoside beta-glucosidase activity", "d": ["Catalysis of the reaction: daidzein 7-O-beta-D-glucoside + H2O = daidzein + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186780", "l": "PI3-kinase binds to the active receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876446", "l": "p-ULK1 phosphorylates DENND3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818682", "l": "MEN1 binds MLL2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72672", "l": "The 60S subunit joins the translation initiation complex  (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614461", "l": "Tetramerization of procollagen VI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432110", "l": "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141671", "l": "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9861616", "l": "DLD dimer dehydrogenates dihydrolipoyl (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047552", "l": "2-oxoaldehyde dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73349", "l": "beta-alanyl-tryptamine + H(+) + holo-[peptidyl-carrier protein] => beta-alanyl-[peptidyl-carrier protein] + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21359", "l": "L-arabinitol + NAD(+) <=> H(+) + L-ribulose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69171", "l": "H2O + NAD(+) + spermine monoaldehyde <=> 2 H(+) + N-(2-carboxyethyl)spermidine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216048", "l": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17545", "l": "[protein]-dithiol + ATP + S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] = [protein]-disulfide + ADP + phosphate + S-hydroxy-L-cysteinyl-[peroxiredoxin]", "d": [], "t": []}, {"i": "EC:1.8.98.2", "l": "\"sulfiredoxin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856223", "l": "B4GALNT1 dimer transfers GalNAc to gangliosides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11680", "l": "ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate", "d": [], "t": []}, {"i": "EC:6.3.5.2", "l": "\"GMP synthase (glutamine-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35716", "l": "(2S,3S)-versiconal hemiacetal acetate + H2O => (2S-3S)-versiconal hemiacetal + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21580", "l": "(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.5", "l": "\"acetolactate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35184", "l": "5-hydroxythiophene-2-carbonyl-CoA + H2O => 4-carboxy-2-thioxobutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75653", "l": "12,13-epoxy-(10R)-hydroxy-(8E,15Z)-octadecadienoate => (10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21880", "l": "2 H(+) + O2 + oxalate = 2 CO2 + H2O2", "d": [], "t": []}, {"i": "EC:1.2.3.4", "l": "\"oxalate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5625959", "l": "Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449829", "l": "IL11 binds IL11RA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005250", "l": "A-type (transient outward) potassium channel activity", "d": ["Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential."], "t": []}, {"i": "REACT:R-HSA-5577234", "l": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010641", "l": "AKAP5 recruits PKA to ROBO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64777", "l": "3-sulfanylpentan-1-ol-L-cysteine => 2-aminoprop-2-enoate + 3-sulfanyl-1-pentanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78255", "l": "D-ornithine + H2O + O2 = 5-amino-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39112", "l": "4-hydroxy-2,5-dimethyl-furan-3(2H)-one + NADP(+) => 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875623", "l": "SLC25A18,22 import L-Glu, H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193641", "l": "IKK-beta is recruited (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682896", "l": "LC3:ATG7 dimer binds ATG3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388863", "l": "Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60794", "l": "3 CO2 + gibberellin A17 + H(+) + H2O + 3 succinate => 3 2-oxoglutarate + gibberellin A53 + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655852", "l": "Expression of Lathosterol Oxidase (SC5D, SC5DL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36517", "l": "3-oxohexacosanoyl-CoA + CO2 + CoA => H(+) + malonyl-CoA + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-983156", "l": "Polyubiquitination of substrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944220", "l": "Association of procollagen type XXIII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9653595", "l": "pS181-S-Farn-Me KRAS4B binds BCL2L1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "68.767689777465833", "identifiers": [{"i": "GO:0004175", "l": "endopeptidase activity", "d": ["Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903089", "l": "5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity", "d": ["Enables the transfer of 5-amino-1-ribofuranosylimidazole-4-carboxamide from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6810376", "l": "ING2 binds PI5P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33629", "l": "AMP + decanoyl-CoA + diphosphate => ATP + CoA + decanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-372480", "l": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71201", "l": "L-ornithine(out) => L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.63", "l": "\"pseudobaptigenin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855154", "l": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9770141", "l": "Formation of the Spliceosomal C* complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.24", "l": "\"neopinone isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38327", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664879", "l": "ATM:PEX5 binds ATM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48720", "l": "aurachin B + H2O + NAD(+) = 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.394", "l": "\"aurachin B dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30545", "l": "(S)-carnitinyl-CoA + ADP + phosphate => (S)-carnitine + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.117", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475422", "l": "PTPS is phosphorylated by cGMP-dependant protein kinase II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53955", "l": "4-aminobutanoyl-[BtrI ACP] + ATP + L-glutamate <=> 4-(gamma-L-glutamylamino)butanoy-[BtrI ACP] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33680", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N-tetracosanoylsphinganine + O2 => 2 Fe(III)-[cytochrome b5] + H2O + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-416690", "l": "SEMA4A binds to PLXND1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444572", "l": "Zinc is an agonist of GPR39 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70315", "l": "beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19448", "l": "2,3-dihydroxyindole + O2 <=> anthranilate + CO2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74182", "l": "a secondary alkyl amine + H2O + NADP(+) <=> a ketone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6805507", "l": "APAF1 binds AVEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31784", "l": "H2O + tuberculosinyl diphosphate => diphosphate + tuberculosinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78445", "l": "a 1,2-diacylglycerol + a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75078", "l": "dihydro-6-demethylsterigmatocystin + S-adenosyl-L-methionine <=> dihydrosterigmatocystin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937682", "l": "RUNX1 binds SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-915148", "l": "Correctly folded glycoproteins translocate to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9856718", "l": "HPDL dioxygenates HPPA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42550", "l": "pseudouridine(746) in 23S rRNA => uridine(746) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74586", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-glutamyl-[protein] <=> N-acetyl-L-cysteine + N-terminal L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052751", "l": "GDP-mannose hydrolase activity", "d": ["Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204549", "l": "Caveolin-1 binds Basigin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48997", "l": "3-methylcatechol + O2 => 2-hydroxy-6-oxo-2,4-heptadienoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37911", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28192", "l": "2'-deoxyinosine + NH4(+) => 2'-deoxyadenosine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-400677", "l": "Rnd1 interacts with Plexin-B1:Sema4D (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38314", "l": "carminomycin + S-adenosyl-L-methionine <=> daunorubicin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29942", "l": "H(+)(in) + phosphate(in) <=> H(+)(out) + phosphate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51425", "l": "a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O => ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-448728", "l": "IL19 binds IL20RA:JAK1:IL20RB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250531", "l": "ARV1 transports CHOL from ER membrane to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9033485", "l": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937744", "l": "PTPN11 binds p-7Y-RUNX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31610", "l": "rhodopin <=> all-trans-lycopene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102428", "l": "kaempferol-3-O-glucoside 1,6-glucosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-alpha-D-glucose = kaempferol-3-gentiobioside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51802", "l": "adlupulone + diphosphate + H(+) => deoxyadlupulone + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29898", "l": "ATP + H2O + L-glutamine(out) <=> ADP + H(+) + L-glutamine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855216", "l": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69071", "l": "AH2 + 2 N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline <=> A + 2 N(delta)-hydroxy-N(omega)-methyl-L-citrulline + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876789", "l": "CARNMT1 methylates CARN to Anserine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77780", "l": "2-oxoglutarate + 6-sulfo-D-quinovose + O2 => 6-dehydro-D-glucose + CO2 + H(+) + succinate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700658", "l": "ceritinib-resistant ALK mutants don't bind ceritinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432121", "l": "LDL binds to LRP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77623", "l": "(2E)-decenoyl-CoA + H(+) + oxaloacetate = (4-octa-1-enyl-2,5-dioxo-2,5-dihydro-3-furanyl)acetate + CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74608", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-galactosamine(out) => UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-galactosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5672960", "l": "YWHAB dimer dissociates from dephosphorylated RAF (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033516", "l": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62629", "l": "a hydroperoxide + H(+) + NADH => an alcohol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69891", "l": "Phosphorylation and activation of CHEK2 by ATM (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12686", "l": "2 mycothiol + NADP(+) => H(+) + mycothione + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40507", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26303", "l": "(S)-allantoin + CO2 => 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008789", "l": "altronate dehydratase activity", "d": ["Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55857", "l": "all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948034", "l": "FGR binds LDL:LRP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38918", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O <=> 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71138", "l": "H(+)(in) + L-histidine(out) + Na(+)(out) <=> H(+)(out) + L-histidine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692408", "l": "NPR2 binds NPPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45277", "l": "12-phosphooxy-(9E)-octadecenoate + H2O => 12-hydroxy-(9E)-octadecenoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237047", "l": "CA4:Zn2+ hydrates CO2 to HCO3- (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21824", "l": "2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate", "d": [], "t": []}, {"i": "EC:2.6.1.1", "l": "\"aspartate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5665802", "l": "SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50540", "l": "prostaglandin A2 = prostaglandin C2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47823", "l": "H(+) + N(6)-(dimethylallyl)adenosine 5'-triphosphate + NADPH + O2 <=> 9-ribosyl-trans-zeatin 5'-triphosphate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111879", "l": "PIP2 hydrolysis (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032867", "l": "L-arabinose reductase (NADPH) activity", "d": ["Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614271", "l": "Autocleavage of ADGRG6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-400027", "l": "Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21998", "l": "a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA => a 1-O-alkyl-2-acetyl-sn-glycerol + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43025", "l": "an S-substituted L-cysteine => 2-aminoprop-2-enoate + a thiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626549", "l": "IQGAPs bind CALM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44604", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75140", "l": "4-hydroxyprotoasukamycin + H(+) + NADH + O2 => asukamycin + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18191", "l": "[(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+) => [(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-442749", "l": "CaMKK autophosphorylates in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61812", "l": "3beta-hydroxyandrost-5-en-17-one + UDP-alpha-D-glucose = dehydroepiandrosterone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44827", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1,2-diacylglycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40162", "l": "H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose <=> NAD(+) + UDP-2-acetamido-2,6-dideoxy-beta-L-talose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57464", "l": "(E)-caffeate + UDP-alpha-D-glucose = 1-O-[(E)-caffeoyl]-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-432096", "l": "Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9835121", "l": "Heparin binds PKR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42955", "l": "cytidine(49) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008048", "l": "calcium sensitive guanylate cyclase activator activity", "d": ["Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3315455", "l": "Defective CBLIF does not bind Cbl (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1302698", "l": "PRLR associates with JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33026", "l": "6-phospho-D-gluconate + NAD(+) <=> CO2 + D-ribulose 5-phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43077", "l": "erythrodiol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oleanolic aldehyde + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58497", "l": "choline + H(+) + NADH + O2 => glycolaldehyde + H2O + NAD(+) + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202212", "l": "Recruitment of PLC-gamma1 to LAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389348", "l": "Activation of Rac1 by pVav1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18626", "l": "D-galactose + NADP(+) => D-galactono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38328", "l": "1,2-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68292", "l": "L-seryl-[protein] + nonanoyl-CoA = CoA + O-nonanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15722", "l": "glycine + H2O + NAD(+) => glyoxylate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43384", "l": "ATP + L-arginyl-[protein] = ADP + H(+) + N(omega)-phospho-L-arginyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.14.1", "l": "\"protein arginine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53483", "l": "3beta-hydroxy-5alpha-androstan-17-one + H(+) + NADPH <=> 5alpha-androstane-3beta,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9632038", "l": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77539", "l": "2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54384", "l": "a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43892", "l": "[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine", "d": [], "t": []}, {"i": "EC:2.8.1.7", "l": "\"cysteine desulfurase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177930", "l": "GAB1 phosphorylation by EGFR kinase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009309", "l": "RUNX2 binds STUB1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36843", "l": "(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51456", "l": "H2O + N-(9Z-octadecenoyl)-L-isoleucine = (9Z)-octadecenoate + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38429", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+) + hexadecanoate => 1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004146", "l": "dihydrofolate reductase activity", "d": ["Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0008865", "l": "fructokinase activity", "d": ["Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6798528", "l": "S100A8:S100A9 binds Mn2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51786", "l": "deoxyhumulone + diphosphate => 4-prenylphlorisovalerophenone + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047962", "l": "glycine N-benzoyltransferase activity", "d": ["Catalysis of the reaction: benzoyl-CoA + glycine = N-benzoylglycine + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20946", "l": "caffeine + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + theobromine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5631885", "l": "PRDX1 overoxidizes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0042912", "l": "colicin transmembrane transporter activity", "d": ["Enables the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69956", "l": "Ca(2+)(in) + 3 Na(+)(out) => Ca(2+)(out) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22105", "l": "2-oxoglutarate + nicotianamine => 3''-deamino-3''-oxonicotianamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78881", "l": "a short-chain 3-oxoacyl-CoA + H(+) + NADH => a short-chain (3R)-hydroxy fatty acyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18057", "l": "O2 + Watasenia luciferin = CO2 + hnu + oxidized Watasenia luciferin", "d": [], "t": []}, {"i": "EC:1.13.12.8", "l": "\"Watasenia-luciferin 2-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76683", "l": "ATP + CoA + sulfoacetate = ADP + phosphate + sulfoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748991", "l": "XDH oxidises 6MP to 6TU (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57996", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose = (20S)-ginsenoside Rh2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68944", "l": "esculetin + S-adenosyl-L-methionine = H(+) + isoscopoletin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2045911", "l": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42455", "l": "4-(2-aminophenyl)-2,4-dioxobutanoate <=> H2O + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621386", "l": "TRIB1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4167511", "l": "HLCS biotinylates ACACB (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12166", "l": "adenosine 3',5'-bisphosphate + an aryl sulfate + H(+) => 3'-phosphoadenylyl sulfate + a phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28623", "l": "(-)-vetispiradiene + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + solavetivol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66729", "l": "ATP + H2O + N-acetyl-L-aspartyl-L-glutamate(in) => ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41937", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose => a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13067", "l": "ADP + H(+) + phosphate => ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34123", "l": "3,5,7-trioxododecanoyl-CoA = CoA + H(+) + olivetolate", "d": [], "t": []}, {"i": "EC:4.4.1.26", "l": "\"olivetolic acid cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16729", "l": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35611", "l": "menadiol + 2 O2 = 2 H(+) + menadione + 2 superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23672", "l": "a quinone + L-quinate = 3-dehydroquinate + a quinol", "d": [], "t": []}, {"i": "EC:1.1.5.8", "l": "\"quinate/shikimate dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0030557", "l": "tRNA modification guide activity", "d": ["Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.02616462956729", "identifiers": [{"i": "GO:0016647", "l": "oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen."], "t": []}, {"i": "EC:1.5.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30437", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + tRNA(Gly) => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5674130", "l": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33508", "l": "sphing-4-enine 1-phosphate => (2E)-hexadecenal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051745", "l": "4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity", "d": ["Catalyzes the conversion of (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H+ + 2 reduced [2Fe-2S]-[ferredoxin] to isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) releasing H2O + 2 oxidized [2Fe-2S]-[ferredoxin]. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32551", "l": "(2E)-geranyl diphosphate + H2O = (S)-alpha-terpineol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.111", "l": "\"(-)-alpha-terpineol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30377", "l": "(+)-thujopsene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-873918", "l": "Transphosphorylation of JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173680", "l": "Activation of C5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48859", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 <=> (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694438", "l": "GalNAc is transferred onto 3a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9673053", "l": "PM20D1 transforms oleoyl-phe from oleate and phe (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71464", "l": "H2O + substance P => Gly-L-Leu-L-Met-NH2 + substance P(1-8)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848873", "l": "PTK6 phosphorylates ARAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138459", "l": "WNT5A:FZD4 is endocytosed (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15001", "l": "keto-L-sorbose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.123", "l": "\"sorbose 5-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52968", "l": "hyocholate + UDP-alpha-D-glucuronate = H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35796", "l": "2'-deamino-2'-hydroxyneamine + UDP-alpha-D-kanosamine => H(+) + kanamycin A + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3642203", "l": "Dimeric TGFB1 does not bind TGFBR2 MSI frameshift mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9699575", "l": "FOXO3-dependent CDKN1B gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.81", "l": "\"(-)-cyclopenine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693071", "l": "BACE1 translocates from ER lumen to Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40791", "l": "H2O + hexacosanoyl-CoA = CoA + H(+) + hexacosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9714691", "l": "RAC3 binds ER effectors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25005", "l": "L-tryptophan + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + N-hydroxy-L-tryptophan + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68324", "l": "1D-myo-inositol 2,5-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018522", "l": "benzoyl-CoA reductase activity", "d": ["Catalysis of the reaction: 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 phosphate = 2 ATP + 2 H2O + benzoyl-CoA + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140956", "l": "histone H3K79 trimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl79-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl79-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of up to three methyl group to the lysine residue at position 79 of the histone H3 protein, producing H3K79me3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097063", "l": "cadmium ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878654", "l": "ACP6 hydrolyses MYS-LPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1247668", "l": "Hemoglobin A binds O2, releasing H+ and CO2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29017", "l": "phosphate(in) + sn-glycerol 3-phosphate(out) => phosphate(out) + sn-glycerol 3-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601919", "l": "Unknown nuclease cleaves cleaved transposon RNA bound in MeR-PIWIL4:cleaved transposon RNA:TDRD9:MAEL:TDRKH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78095", "l": "a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49306", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + N-acetyl-alpha-D-galactosamine => a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193491", "l": "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-964825", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17644", "l": "H(+) + L-arginine <=> agmatine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13578", "l": "a wax ester + H2O => a long chain fatty alcohol + a long-chain fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73813", "l": "GAR + 10-Formyl-THF => FGAR + THF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24699", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030749", "l": "loganate O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-398193", "l": "PLC beta-mediated PIP2 hydrolysis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202394", "l": "Translocation of CARMA1 to Plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60134", "l": "a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate => a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28998", "l": "H(+)(out) + L-threonine(in) <=> H(+)(in) + L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2400009", "l": "PI3K inhibitors block PI3K catalytic activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.3", "l": "\"phosphoserine phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-446189", "l": "Addition of a second glucose to the N-glycan precursor by ALG8 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48508", "l": "cholate + NADP(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3247843", "l": "secretion of WNT ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70204", "l": "N-methyldopaminechrome => 5,6-dihydroxyindole-N-methyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102594", "l": "cyanidin 7-O-glucoside acyltransferase(acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose = cyanidin 3-O-glucoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.36", "l": "\"signal peptidase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62684", "l": "norrubrofusarin + S-adenosyl-L-methionine = H(+) + rubrofusarin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23881", "l": "L-histidyl-[protein] + phosphoenolpyruvate => N(pros)-phospho-L-histidyl-[protein] + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9658253", "l": "RAS:GTP binds PI3K (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73413", "l": "succinate(out) + sulfate(in) => succinate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31358", "l": "dimethyl sulfide + H(+) + NADH + O2 <=> formaldehyde + H2O + methanethiol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684096", "l": "CDK2 phosphorylates RBBP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69314", "l": "benzyl thiocyanate + sulfate => (Z)-phenyl-N-(sulfonatooxy)methanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050242", "l": "pyruvate, phosphate dikinase activity", "d": ["Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H+ + phosphoenolpyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9707606", "l": "PGRMC2:Hemes translocate to the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2562526", "l": "PLK1 phosphorylates OPTN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20560", "l": "2 H(+) + H2O + urea <=> CO2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1227670", "l": "Recruitment of HDAC1 by p130 (RBL2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30240", "l": "n a quinone + n H(+) + n hydrogen sulfide => n a quinol + n sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2731122", "l": "Syndecans 1, 2 & 4 bind VTN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43319", "l": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65164", "l": "benzoyl-CoA + hexan-3-ol = CoA + hexan-3-yl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0004169", "l": "dolichyl-phosphate-mannose-protein mannosyltransferase activity", "d": ["Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49342", "l": "2-hydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + spirilloxanthin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75919", "l": "H2O + NADP(+) + serinol = dihydroxyacetone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53544", "l": "chlorophyll a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = 7(1)-hydroxychlorophyll a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75370", "l": "cytidine(in) <=> cytidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395257", "l": "Formation of dehydro-hydroxylysino-norleucine cross-links (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5622129", "l": "FABP5 binds atRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70489", "l": "a 2'-deoxyguanosine in double-stranded DNA + CO2 + glyoxal + succinate => 2-oxoglutarate + a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9026006", "l": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76189", "l": "an L-amino acid tripeptide(in) + 2 H(+)(in) => an L-amino acid tripeptide(out) + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68786", "l": "diphosphate + gamma-curcumene => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36593", "l": "2-chloroacrylate + H(+) + NADPH => (S)-2-chloropropanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15732", "l": "D-mannonate + NAD(+) <=> H(+) + keto-D-fructuronate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196417", "l": "Reduction of desmosterol to cholesterol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48935", "l": "a ganglioside GT1b + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GQ1b + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77686", "l": "a globoside Gb3Cer (d18:1(4E)) + UDP-alpha-D-galactose <=> a globoside GalGb3Cer (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12727", "l": "H(+) + keto-D-sorbose + NADH => D-iditol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451377", "l": "Interaction of IQGAP1 with nephrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0047661", "l": "amino-acid racemase activity", "d": ["Catalysis of the reaction: an L-amino acid = a D-amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10490", "l": "(6R)-5,10-methenyltetrahydrofolate + ADP + phosphate => (6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58732", "l": "5-methyl-CTP + H2O = 5-methyl-CMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433418", "l": "Phosphorylation of JAK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350441", "l": "FLW:MYPT-75D complex dephosphorylates SQH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787677", "l": "FUOM isomerises alpha-Fuc to beta-Fuc (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-168412", "l": "MDP elicits a NOD2 response (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020253", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-927830", "l": "Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696268", "l": "RND3 binds effectors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49430", "l": "CMP-5'-phosphonoformate + diphosphate => CTP + phosphonoformate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71654", "l": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16745", "l": "AH2 + O2 + phylloquinone = 2,3-epoxyphylloquinone + A + H2O", "d": [], "t": []}, {"i": "EC:1.14.99.20", "l": "\"phylloquinone monooxygenase (2,3-epoxidizing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13737", "l": "an n-alkanal + NADP(+) = an alk-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39527", "l": "(2E,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + NADPH = (17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29547", "l": "H2O + UDP-N-acetyl-alpha-D-glucosamine = 2 H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692867", "l": "HRH3 binds pitosilant (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9833777", "l": "PKR binds activating host RNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.201", "l": "\"exo-chitinase (reducing end)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102854", "l": "1-18:2-2-18:1-phosphatidylcholine desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:3-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-418574", "l": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683888", "l": "LMCD1 binds GATA6, sequestering it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15846", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose => 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50545", "l": "prostaglandin C2 => prostaglandin B2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73619", "l": "CTP(out) + GTP(in) = CTP(in) + GTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10510", "l": "aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate => D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016155", "l": "formyltetrahydrofolate dehydrogenase activity", "d": ["Catalysis of the reaction: 10-formyltetrahydrofolate + H2O + NADP+ = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2509827", "l": "ITPA hydrolyses ITP to IMP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53766", "l": "allocholoyl-CoA + lithocholate => allocholate + lithocholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928615", "l": "EFNBs bind SFKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11728", "l": "cyclopentanol + NAD(+) = cyclopentanone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.163", "l": "\"cyclopentanol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799977", "l": "PGLYRP2 hydrolyzes bacterial peptidoglycan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1852623", "l": "Ubiquitination of NICD1 by FBWX7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15412", "l": "1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine <=> 1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-187520", "l": "Cyclin E/A:Cdk2-mediated  phosphorylation of p27/p21 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2162188", "l": "COQ5 methylates MDMQ10H2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39967", "l": "2-aminobut-2-enoate = 2-iminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-909738", "l": "SHP1 and SHP2 bind the common beta chain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68851", "l": "(2Z,6E)-farnesyl diphosphate <=> diphosphate + gamma-cadinene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51170", "l": "(R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine => (R)-adrenaline + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690152", "l": "USP5 cleaves polyubiquitin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51468", "l": "(R)-lactate + a quinone = a quinol + pyruvate", "d": [], "t": []}, {"i": "EC:1.1.5.12", "l": "\"D-lactate dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2002401", "l": "Association of procollagen type XVIII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2993799", "l": "HLCS biotinylates 6xMCCC1:6xMCCC2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5333678", "l": "CPNEs bind PL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62427", "l": "(E)-caffeoyl-CoA + H2O <=> 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.1.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5681987", "l": "LC3 is cleaved by ATG4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9634834", "l": "ACHEIs bind ACHE (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78764", "l": "H2O + N-deacetylipecoside => D-glucose + N-deacetylipecoside aglycone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31417", "l": "(+)-2-epi-prezizaene + diphosphate => (2Z,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13989", "l": "alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose", "d": [], "t": []}, {"i": "EC:2.7.7.12", "l": "\"UDP-glucose--hexose-1-phosphate uridylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65642", "l": "CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8Z)-enine => (4R)-hydroxysphing-(8Z)-enine + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49200", "l": "D-mannose 6-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.132", "l": "\"3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375131", "l": "Basigin binds CD98 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64722", "l": "H(+)(in) + pyruvate(in) => H(+)(out) + pyruvate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11671", "l": "[(1->4)-alpha-D-glucosyl](n) + n ATP + n H2O <=> [(1->4)-6-phospho-alpha-D-glucosyl](n) + n AMP + 2n H(+) + n phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675780", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11892", "l": "6-O-methylnorlaudanosoline + S-adenosyl-L-methionine = H(+) + nororientaline + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.121", "l": "\"6-O-methylnorlaudanosoline 5'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49246", "l": "18-oxo-resolvin E1 + H(+) + NADH => NAD(+) + resolvin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11644", "l": "a (2R,3R)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35622", "l": "L-idarate <=> D-glucarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-416929", "l": "PTGFR binds PGF2a (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6793590", "l": "LIPT2 transfers octanoyl group to GCSH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32210", "l": "(2E,4Z)-2-hydroxyhexa-2,4-dienedioate <=> (3Z)-2-oxohex-3-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15708", "l": "2 a ubiquinone + H2O + phenylacetyl-CoA <=> 2 a ubiquinol + phenylglyoxylyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696958", "l": "USP44 deubiquitinates CDC20 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78171", "l": "demethylgadusol + S-adenosyl-L-methionine = gadusol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.391", "l": "\"demethylgadusol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445064", "l": "Activation of Rac1 by VAV2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11571", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dCMP <=> 5-methyldeoxycytidine 5'-phosphate + 7,8-dihydrofolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482781", "l": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48734", "l": "[CysO sulfur-carrier protein]-C-terminal Gly-Gly + H(+) + L-cysteine => [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75022", "l": "1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate <=> 2,3-di-(10Z-heptadecenoyl)-sn-glycerol + 9-(10Z-heptadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67576", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34260", "l": "(+)-larreatricin + AH2 + O2 => (+)-3'-hydroxylarreatricin + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794523", "l": "SLC22A1 transports Cipro into renal cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252133", "l": "ATP6AP1 binds V-ATPase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9854672", "l": "FAD attaches to SDHA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-167429", "l": "The receptor:G-protein complex  binds GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42994", "l": "(R)-nephthenol + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60371", "l": "urate(out) <=> urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62382", "l": "1-naphthol + CO2 + methylamine => carbaryl + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12029", "l": "H2O + L-5-carboxymethylhydantoin => H(+) + N-carbamoyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035175", "l": "histone H3S10 kinase activity", "d": ["Catalysis of the reaction: histone H3-serine (position 10) + ATP = histone H3-phosphoserine (position 10) + ADP. This reaction is the addition of a phosphate group to the serine residue at position 10 of histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78007", "l": "a 1,2-diacyl-3-(9Z,12Z-octadecadienoyl)-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine = a 1,2-diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13527", "l": "(1R,4R,5R)-5-hydroxycamphor + H2O + 2 oxidized [2Fe-2S]-[putidaredoxin] => (1R,4R)-camphor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[putidaredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.6.1.6", "l": "\"channel-conductance-controlling ATPase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-500366", "l": "LIN28 binds POU5F1 (OCT4) mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16484", "l": "3 S-adenosyl-L-methionine <=> 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76574", "l": "4-deoxy-L-erythro-hex-4-enopyranuronate <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-201640", "l": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha  (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9657603", "l": "Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130378", "l": "Transport of MHC II:Ii complex to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391266", "l": "Association of CCT/TriC with sphingosine kinase 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69764", "l": "a medium-chain fatty aldehyde + H2O + NAD(+) => a medium chain fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-420977", "l": "Ca permeable AMPA receptor ligand binding (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0097027", "l": "ubiquitin-protein transferase activator activity", "d": ["Binds to and increases the activity of a ubiquitin-protein transferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43634", "l": "an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe) => an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25030", "l": "ADP-alpha-D-ribose 1''-phosphate + H2O => ADP-D-ribose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018458", "l": "isopiperitenol dehydrogenase activity", "d": ["Catalysis of the reaction: (1S,6R)-isopiperitenol + NAD+ = (6R)-isoperitenone + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209910", "l": "Iodide is taken up by thyroid epithelial cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1028816", "l": "Translocation of phosphorylated IRF3,IRF7 dimers into nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74513", "l": "aspoquinolone A => (1'E,3'E)-5-(3,3-dimethyloxiran-2-yl)-3-methylhexa-1,3-dienyl-quinolinone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626681", "l": "Recruitment of transition zone proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9679029", "l": "C-ter TLR7 dimer binds HCQ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73401", "l": "D-aspartate(out) + sulfate(in) => D-aspartate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24176", "l": "[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:2.8.1.4", "l": "\"tRNA uracil 4-sulfurtransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59214", "l": "AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase] => holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043136", "l": "glycerol-3-phosphatase activity", "d": ["Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10351", "l": "5-oxo-L-proline + ATP + 2 H2O <=> ADP + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684887", "l": "Activation of CHEK1 at resected DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37444", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008815", "l": "citrate (pro-3S)-lyase activity", "d": ["Catalysis of the reaction: citrate = acetate + oxaloacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19263", "l": "ADP + H(+) + heme b(out) + phosphate => ATP + H2O + heme b(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814124", "l": "ATP binds G-protein beta associated TRiC/CCT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38601", "l": "nicotinamide + nicotinate-adenine dinucleotide phosphate => NADP(+) + nicotinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20298", "l": "an anilide + H2O => a carboxylate + aniline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68411", "l": "(2R,3S)-iso(homo)3citrate + NAD(+) <=> 2-oxosuberate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193965", "l": "CYP11B2 oxidises 18HCORST to ALDO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033417", "l": "CUU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8931648", "l": "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20201", "l": "ATP + H2O + L-phenylalanine = AMP + D-phenylalanine + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:5.1.1.11", "l": "\"phenylalanine racemase (ATP-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375384", "l": "Bombesin-like receptors bind bombesin homologues (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41773", "l": "a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GQ1b (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34313", "l": "2-hydroxy-1,4-benzoquinone + H2O + NAD(+) + nitrite => 4-nitrocatechol + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53809", "l": "cholestanol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholestanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66533", "l": "ATP + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein] => diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11699", "l": "3'-demethylstaurosporine + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + staurosporine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018833", "l": "DDT-dehydrochlorinase activity", "d": ["Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170666", "l": "Adenylate cyclase increases the GTPase activity of G alpha-olf (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37683", "l": "1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913529", "l": "Translocation of p-STAT1:p-STAT1 dimer to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76456", "l": "O-atom dealkylation of dextromethorphan (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77123", "l": "1D-myo-inositol 1,2,3,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,3-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6789310", "l": "LIPs hydrolyse TG to DAG and RCOOH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67470", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine => H2O + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39602", "l": "3-oxo-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78332", "l": "UMP + UTP => 2 UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180603", "l": "Proteosome-mediated degradation of APOBEC3G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33274", "l": "a triacyl-sn-glycerol + H2O <=> a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864737", "l": "TFAP2A homodimer binds the VEGFA gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51717", "l": "ATP(in) + CoA(in) + H(+)(out) + hexadecanoate(out) => AMP(in) + diphosphate(in) + H(+)(in) + hexadecanoyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75695", "l": "2'-deoxycytidine(in) = 2'-deoxycytidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65587", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 8-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57590", "l": "(2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202692", "l": "PIP3 binds to RhoA and activates it (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2730847", "l": "Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15755", "l": "GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate => GTP + IMP + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174367", "l": "GCL ligates L-Glu to L-Cys (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40009", "l": "(+)-copalol + diphosphate => (+)-copalyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77917", "l": "holo-[peptidyl-carrier protein] + pre-pseudomonine => N-hydroxyhistamine + salicylmethyloxazolinyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68445", "l": "5-cis-lycopene + O2 => (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one + 5-cis-10'-apo-lycopenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682101", "l": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61155", "l": "(E)-caffeoyl-CoA + myricetin 3-O-[beta-D-glucosyl-(1->2)-alpha-L-rhamnoside] <=> CoA + myricetin 3-O-[(6-O-(E)-caffeoyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805479", "l": "TP53RK phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937075", "l": "Phosphorylated TAK1 leaves activated TLR receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199839", "l": "AKT can phosphorylate RSK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58439", "l": "4-methylpentan-1-ol + NADP(+) <=> 4-methylpentanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804741", "l": "MDM2 forms homo- or heterodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50068", "l": "ATP + glycoursodeoxycholate(in) + H2O = ADP + glycoursodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9669893", "l": "KIT binds type I TKIs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34437", "l": "4-(3-methylbut-2-enyl)-L-abrine + H(+) + S-adenosyl-L-homocysteine => 4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55177", "l": "2-oxoglutarate + butanoyl-CoA + O2 => 2-hydroxybutanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047804", "l": "cysteine-S-conjugate beta-lyase activity", "d": ["Catalysis of the reaction: S-substituted L-cysteine + H2O = a thiol + NH4+ + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29485", "l": "(+)-beta-selinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63418", "l": "2-chloro-6-hydroxy-1,4-benzoquinone + chloride + FAD + 2 H(+) + H2O => 2,6-dichlorohydroquinone + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981120", "l": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654684", "l": "CBL ubiquitinates FRS2 and FGFR4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51374", "l": "CoA + H(+) + N-(9Z-hexadecenoyl)-glycine => (9Z)-hexadecenoyl-CoA + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018542", "l": "2,3-dihydroxy DDT 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392749", "l": "Transport of L1 into endosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15419", "l": "CO2 + L-tyrosine + NADPH => L-arogenate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851436", "l": "CFHR dimers bind C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43651", "l": "H(+) + hexadecanoyl-CoA + malonyl-[ACP] <=> 3-oxooctadecanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66736", "l": "ATP + beta-citrylglutamate(in) + H2O = ADP + beta-citrylglutamate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46480", "l": "4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34251", "l": "1-deoxysphinganine + NADP(+) = 1-deoxy-3-dehydrosphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9837337", "l": "DCAKD phosphorylates DP-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114670", "l": "GPIb-IX-V binds to vWF:Collagen complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53078", "l": "5-methylcytidine(34) in mitochondrial tRNA + H(+) + S-adenosyl-L-homocysteine => cytidine(34) in mitochondrial tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76939", "l": "2-methylpropan-1-amine + H2O + NADP(+) = 2-methylpropanal + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855202", "l": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24353", "l": "ethyl (R)-3-hydroxyhexanoate + NADP(+) => ethyl 3-oxohexanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25114", "l": "phosphate + pyridoxine => H2O + pyridoxine 5'-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0004370", "l": "glycerol kinase activity", "d": ["Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9026890", "l": "NTRK2 phosphorylates SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37757", "l": "1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11833", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) => H(+) + NADH + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75645", "l": "(10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36169", "l": "a 2'-deoxyribonucleoside + phosphate => a 2'-deoxyribonucleoside 5'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71900", "l": "3',5'-cyclic GMP + NAD(+) => H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77205", "l": "3alpha-sulfodeoxycholate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + deoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64447", "l": "L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-168921", "l": "TRIF:activated TLR3/TLR4 complex recruits RIP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37837", "l": "epsilon-rhodomycinone + H2O + NADP(+) => aklavinone + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41831", "l": "(3R)-hydroxyhexanoyl-[ACP] <=> (2E)-hexenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000074", "l": "TCN2 binds RCbl in the circulation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73769", "l": "Loss of Rrn3 from RNA Polymerase I promoter escape complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-749453", "l": "Liganded Gz-activating GPCR acts as a GEF for Gz (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9792608", "l": "SLC35D2 exchanges UDP-D-glucose for UMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52580", "l": "ATP + H2O + Pb(2+)(in) = ADP + H(+) + Pb(2+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1236965", "l": "Export of peptide loaded MHC class I complex to PM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446218", "l": "Addition of the first mannose to the N-glycan precursor by ALG1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40927", "l": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39242", "l": "(2E)-triacontenoyl-CoA + H(+) + NADPH <=> NADP(+) + triacontanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77965", "l": "(5R,12R,14S)-dolasta-1(15),8-diene + diphosphate => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9692800", "l": "CDC42 translocates to the endoplasmic reticulum membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48463", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O <=> 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73895", "l": "ATP + L-glutamate + spermine = ADP + gamma-L-glutamylspermine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000825", "l": "inositol tetrakisphosphate 6-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4093332", "l": "p-EPHB phosphorylates SDC2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36872", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-982765", "l": "Growth hormone forms dimers and oligomers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68269", "l": "dUMP + formaldehyde + H(+) + NADPH => dTMP + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36902", "l": "guanosine(37) in tRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23896", "l": "5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate", "d": [], "t": []}, {"i": "EC:5.3.1.17", "l": "\"5-dehydro-4-deoxy-D-glucuronate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0031705", "l": "bombesin receptor binding", "d": ["Binding to a bombesin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58691", "l": "NADH + O2 + rifamycin SV <=> H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58526", "l": "(16S)-deshydroxymethyl-stemmadenine + formate + NADP(+) => 15alpha-stemmadenine intermediate I + H2O + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-374919", "l": "Noradrenaline clearance from the synaptic cleft (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928597", "l": "EPH:EFN dimers tetramerise (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68307", "l": "3'-phosphoadenylyl sulfate + 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] <=> 3-O-{O-3-S-beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63338", "l": "beta-D-xylose => alpha-D-xylose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2090079", "l": "GLB1 hydrolyses linker chain(2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57914", "l": "H(+) + L-glutaminyl-tRNA(Gln) + phosphate => 5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12537", "l": "H(+) + L-arogenate => CO2 + H2O + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44553", "l": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O => H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57430", "l": "formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase] + phenol => anisole + O2 + reduced [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354077", "l": "Integrin alphaIIb beta3 activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1307955", "l": "FGFR4 binds HS:KLB:FGF19 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27487", "l": "(S)-2-ureidoglycine + CO2 + NH4(+) => allantoate + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5683888", "l": "LMCD1 binds GATA6, sequestering it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48294", "l": "a ganglioside Fuc-GM1 + GDP + H(+) => a ganglioside GM1 + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65834", "l": "A + ADP + 2 Co(I)-[dimethylamine-specific corrinoid protein] + 3 H(+) + phosphate => AH2 + ATP + 2 Co(II)-[dimethylamine-specific corrinoid protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59268", "l": "A + H2O + N(6)-methyl-L-lysyl-[protein] = AH2 + formaldehyde + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16355", "l": "L-glutamate + sulfoacetaldehyde => 2-oxoglutarate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-381543", "l": "IGFBP4 binds IGF forming IGF:IGFBP4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9036301", "l": "ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517444", "l": "TAT aminates HPP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24224", "l": "(1R,6S)-1,6-dihydroxy-4-methylcyclohexa-2,4-diene-1-carboxylate + NADP(+) = 4-methylcatechol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9734193", "l": "Defective APRT does not convert adenine to AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004796", "l": "thromboxane-A synthase activity", "d": ["Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32170", "l": "ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> aerobactin + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52118", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate => 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690023", "l": "NUBPL binds 4Fe-4S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114558", "l": "Thrombin-activated PARs activate Gq (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444705", "l": "T1R1/T1R3 dimer is the umami taste receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009042", "l": "valine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18834", "l": "4-formylbenzenesulfonate + H2O + NAD(+) => 4-sulfobenzoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4088130", "l": "PLK1 binds FOXM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2514865", "l": "cGMP dissociates from CNG channels (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449818", "l": "IL13 binds IL13RA2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19228", "l": "glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78053", "l": "1-O-alkyl-2-acetyl-3-acylglycerol + a 1-acyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29067", "l": "formate + H(+) + menaquinone-8 = CO2 + menaquinol-8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034870", "l": "pinacolone 5-monooxygenase activity", "d": ["Catalysis of the reaction: 2,2-dimethyl-3-pentanone + 1/2 O2 = 1-hydroxy-4,4-dimethylpentan-3-one."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17299", "l": "CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA => 2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77745", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a triacylglycerol => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62298", "l": "(+)-malbrancheamide + 2 FADH2 => (+)-premalbrancheamide + 2 chloride + 2 FAD + 4 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50738", "l": "a quinol + thiosulfate => a quinone + 2 H(+) + hydrogen sulfide + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.123", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34233", "l": "4-nitro-6-oxohepta-2,4-dienedioate + H(+) => 5-nitrosalicylate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12911", "l": "2 Fe(III)-[cytochrome] + H2O + nitrite => 2 Fe(II)-[cytochrome] + 2 H(+) + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64328", "l": "(7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222093", "l": "BRD7 binds TP53 and EP300 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36443", "l": "dihydrochanoclavine-I aldehyde = 6,8-dimethyl-6,7-didehydroergoline + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59853", "l": "(2S,3R)-dihydrodehydrodiconiferyl alcohol + H(+) + NADPH => (R)-tetrahydrodehydrodiconiferyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55920", "l": "[cis-1,4-isoprene](n) + O2 = (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + cis-1,4-isoprene(n-3)", "d": [], "t": []}, {"i": "EC:1.13.11.85", "l": "\"exo-cleaving rubber dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58358", "l": "CO2 + formaldehyde + L-arginyl-[protein] + succinate => 2-oxoglutarate + N(omega)-methyl-L-arginyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682992", "l": "KDM4A,B bind H4K20Me2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388830", "l": "PI3K binds ICOS (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187949", "l": "CAK-mediated phosphorylation of Cyclin A:Cdk2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9815507", "l": "MIB2 ubiquitinates CYLD at K338, K530 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59574", "l": "4-aminobutanoate + L-histidine => H2O + L-homocarnosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22386", "l": "1D-myo-inositol hexakisphosphate + H(+) + phosphate => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112123", "l": "Oxidative demethylation of 1-meA damaged DNA By ALKBH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832006", "l": "Nascent M2-1 binds Zn2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32797", "l": "ADP + H(+) + L-cysteine(in) + phosphate => ATP + H2O + L-cysteine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254248", "l": "Translocation of ERBB4s80:YAP1 complex to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071074", "l": "eukaryotic initiation factor eIF2 binding", "d": ["Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46594", "l": "calcitriol + H2O + 2 oxidized [adrenodoxin] => alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73040", "l": "H(+)(out) + Ni(2+)(out) => H(+)(in) + Ni(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855077", "l": "Ficolin-3 binds to molecular patterns on the target cell surface  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40323", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009065", "l": "FOXA1 and GATA3 bind to CCND1 promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29171", "l": "a ubiquinol + 2 O2 = a ubiquinone + 2 H(+) + 2 superoxide", "d": [], "t": []}, {"i": "EC:1.10.3.17", "l": "\"superoxide oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2032781", "l": "WWTR1 (TAZ) binds TEAD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159752", "l": "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26520", "l": "acryloyl-CoA + H2O => 3-hydroxypropanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-193362", "l": "ABCB11 transports bile salts from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.120", "l": "\"oviductin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2089943", "l": "TRPC1 translocates calcium from the extracellular region to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60293", "l": "L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855375", "l": "PTPN22 dissociates from CSK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928631", "l": "GIT1 binds bPIX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76981", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78032", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol => a 1,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14088", "l": "(2E)-geranyl diphosphate + 5-methylaminomethyl-2-thiouridine(34) in tRNA <=> 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12488", "l": "2-amino-2-deoxy-D-gluconate = 2-dehydro-3-deoxy-D-gluconate + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.9", "l": "\"glucosaminate ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836702", "l": "PKR inhibitors bind PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40131", "l": "(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004042", "l": "acetyl-CoA:L-glutamate N-acetyltransferase activity", "d": ["Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52608", "l": "2-hydroxybutanoate + NADP(+) = 2-oxobutanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20537", "l": "H2O + holo-[ACP] = (R)-4'-phosphopantetheine + apo-[ACP] + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.14", "l": "\"[acyl-carrier-protein] phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28029", "l": "[thioredoxin]-disulfide + dUDP + H2O <=> [thioredoxin]-dithiol + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694527", "l": "Loss of SAR1B GTPase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9733969", "l": "Bile salts dissociate from FABP6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27612", "l": "CO2 + H2 => formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47414", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071820", "l": "N-box binding", "d": ["Binding to an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004826", "l": "phenylalanine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2995388", "l": "PP2A dephosphorylates BANF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375768", "l": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052814", "l": "medium-chain-aldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: a medium-chain aldehyde + NAD+ = a medium-chain carboxylate + NADH + H+. Medium-chain aldehydes have a chain length of between 8 and 12 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46010", "l": "H(+) + NADH + pentanoyl-CoA => CoA + NAD(+) + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10635", "l": "D-mannonate + NAD(+) <=> D-mannuronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13797", "l": "a dolichyl phosphate + H2O = di-trans,poly-cis-dolichol + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.51", "l": "\"dolichyl-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388832", "l": "PI3K binds CD28 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669024", "l": "CD70 binds CD27 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66164", "l": "butanoyl-CoA + serotonin = CoA + H(+) + N-butanoylserotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59879", "l": "(indol-3-yl)butanoate + ATP + L-cysteine <=> (indol-3-yl)butanoyl-L-cysteine + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.9", "l": "\"nucleotide diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33821", "l": "3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate => 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54311", "l": "pseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine <=> H(+) + N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174786", "l": "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416320", "l": "Trafficking of GluR1-containing  AMPA receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183055", "l": "Binding of CBL to EGFR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.-", "l": "\"Phosphorus-oxygen lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31642", "l": "mycinamicin III + S-adenosyl-L-methionine <=> H(+) + mycinamicin IV + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730889", "l": "Recruitment of PAK to the membrane by binding active RAC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9675026", "l": "Formation of the MLL1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9013009", "l": "RHOA binds effectors at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120328", "l": "ATP-dependent DNA (cytosine-5-)-methyltransferase activity", "d": ["Catalytic activity that acts to transfer a methyl group to a DNA molecule, driven by ATP hydrolysis."], "t": []}, {"i": "RHEA:68984", "l": "a 2'-deoxycytidine in DNA + ATP + H2O + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + ADP + 2 H(+) + phosphate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046285", "l": "The keratan chain can be capped by N-acetylneuraminic acid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33567", "l": "A + ethanol = acetaldehyde + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796387", "l": "STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48725", "l": "aurachin B + H(+) + H2O => 3,4-dihydroxy-2-methyl-1-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18087", "l": "coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine => coenzyme B + coenzyme M + methanophenazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987039", "l": "JAK1 binds IL20RA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362551", "l": "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48893", "l": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O => L-threonyl-[protein] + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.358", "l": "\"2-dehydropantolactone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051008", "l": "Hsp27 protein binding", "d": ["Binding to Hsp27 proteins, a lightweight heat shock protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446130", "l": "Interleukin-1 receptor type 2 binds Interleukin 1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27420", "l": "2 Fe(III)-[cytochrome] + H2O + nicotinate <=> 6-hydroxynicotinate + 2 Fe(II)-[cytochrome] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.012360833342299", "identifiers": [{"i": "GO:0004532", "l": "RNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule."], "t": []}, {"i": "REACT:R-HSA-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140872", "l": "thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937792", "l": "RUNX3 binds SRC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8862152", "l": "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16636", "l": "guanosine(34) in tRNA + queuine <=> guanine + queuosine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50330", "l": "1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22107", "l": "2-oxoglutarate + nicotianamine <=> 3''-deamino-3''-oxonicotianamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-212651", "l": "Transport of L-Glutamine (cytosol) to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12882", "l": "ADP-alpha-D-glucose + sn-glycerol 3-phosphate => 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605056", "l": "Expression of SREBF1 (SREBP1) regulated by NR1H2 or NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042943", "l": "D-amino acid transmembrane transporter activity", "d": ["Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75401", "l": "2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(in) => 2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186778", "l": "SHP2 binds to the active receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467775", "l": "Autocleavage of ESPL1 (Separase) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034822", "l": "citronellal dehydrogenase activity", "d": ["Catalysis of the reaction: citronellal + NAD+ + OH- = citronellate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635864", "l": "NUMB:ITCH ubiquitinates GLI1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18913", "l": "a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814831", "l": "TBC1D20 binds RAB1:GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5362437", "l": "C-terminal Hh fragments are bound by lectins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482646", "l": "2-acyl LPE is acylated to PE by LPEAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69904", "l": "cytidine(out) + 2 Na(+)(out) => cytidine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645598", "l": "RRAGC,D hydrolyzes GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140070", "l": "hydrogen peroxide channel activity", "d": ["Enables the energy-independent facilitated diffusion of hydrogen peroxide through a transmembrane aqueous pore or channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823977", "l": "Expression of GATA6 in definitive endoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013438", "l": "RHOD binds effectors at the endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050154", "l": "opheline kinase activity", "d": ["Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = N'-phosphoguanidinoethyl methylphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654224", "l": "Activated FGFR3 binds PLCG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47896", "l": "6-sulfo-D-quinovose + NAD(+) = 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.390", "l": "\"sulfoquinovose 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48292", "l": "a ganglioside GM1 + GDP-beta-L-fucose = a ganglioside Fuc-GM1 + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37864", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + decanoyl-CoA => 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25886", "l": "H(+) + N(2)-succinyl-L-citrulline + phosphate => carbamoyl phosphate + N(2)-succinyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71588", "l": "(S)-malate(in) + 2-oxoglutarate(out) => (S)-malate(out) + 2-oxoglutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0015603", "l": "iron chelate transmembrane transporter activity", "d": ["Enables the transfer of an iron chelate from one side of a membrane to the other. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44759", "l": "2-methoxy-6-all-trans-heptaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine <=> 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-901047", "l": "Binding of ERp57 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193052", "l": "Pregn-5-ene-3,20-dione isomerizes to progesterone (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16469", "l": "(R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1475025", "l": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001632", "l": "leukotriene B4 receptor activity", "d": ["Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031924", "l": "vitamin B6 transmembrane transporter activity", "d": ["Enables the transfer of any of the vitamin B6 compounds, pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114256", "l": "CYCS:APAF1 binds procaspase-9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198211", "l": "Active TRKA binds IRS1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4719413", "l": "PIAS2,3,4 SUMOylate RORA with SUMO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9840334", "l": "PSAP gets cleaved (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1112565", "l": "Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22665", "l": "2 1-O-(trans-sinapoyl)-beta-D-glucose => 1,2-di-O-sinapoyl beta-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432054", "l": "Aquaporin-1 passively transports water out of cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2299725", "l": "PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14120", "l": "[(1->4)-alpha-D-galacturonosyl](n) + H2O <=> [(1->4)-alpha-D-galacturonosyl](n-1) + alpha-D-galacturonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48008", "l": "2-hydroxybenzoyl-CoA + H(+) + NADH + O2 = 2,5-dihydroxybenzoyl-CoA + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.209", "l": "\"salicyloyl-CoA 5-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24754", "l": "3 H(+) + red chlorophyll catabolite + 2 reduced [2Fe-2S]-[ferredoxin] => 2 oxidized [2Fe-2S]-[ferredoxin] + primary fluorescent chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0019972", "l": "interleukin-12 binding", "d": ["Binding to interleukin-12."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031995", "l": "insulin-like growth factor II binding", "d": ["Binding to insulin-like growth factor II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.119", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23791", "l": "acetate + ATP + holo-[citrate lyase ACP] <=> acetyl-[citrate lyase ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28519", "l": "D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O => D-glycero-beta-D-manno-heptose 1-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8849157", "l": "TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56834", "l": "2,3,6-trichlorohydroquinone + 2 glutathione => 2,6-dichlorohydroquinone + chloride + glutathione disulfide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114264", "l": "Translocation of activated BAX to the mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22940", "l": "ATP + L-arginine = ADP + H(+) + N(omega)-phospho-L-arginine", "d": [], "t": []}, {"i": "EC:2.7.3.3", "l": "\"arginine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36874", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10902", "l": "an aromatic oxo-acid + glycine => an aromatic L-alpha-amino acid + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3000449", "l": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191656", "l": "Closure of gap junction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3341343", "l": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76434", "l": "Na(+)(out) + NH4(+)(in) <=> Na(+)(in) + NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047746", "l": "chlorophyllase activity", "d": ["Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40044", "l": "ATP + citrate + L-glutamate => ADP + beta-citrylglutamate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69025", "l": "H(+) + N-hydroxy-L-aspartate + NADPH + O2 => H2O + N,N-dihydroxy-L-aspartate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "47.070198783088777", "identifiers": [{"i": "GO:0022836", "l": "gated channel activity", "d": ["Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3249372", "l": "p-S407,Y641-STAT6 is dimerized (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19630", "l": "D-threo-isocitrate + NADP(+) => 2-oxoglutarate + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51948", "l": "(2S)-2-methylbutanenitrile + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-2-methylbutanenitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69658", "l": "H2O + quercetin 3-O-beta-D-glucoside <=> beta-D-glucose + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879584", "l": "SLCO3A1 isoform 1 has abroad substrate specificity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193369", "l": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211224", "l": "Anthrax cya catalyzes the conversion of ATP to cAMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59618", "l": "beta-alanine + L-arginine => beta-alanyl-L-arginine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62015", "l": "cytidine(2499) in 23S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(2499) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390649", "l": "CHRM1,3,5 bind acetylcholine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43842", "l": "(3beta)-hydroxy-cholest-5-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 26-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9681375", "l": "KIT binds ripretinib (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53217", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67434", "l": "1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53655", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58884", "l": "AH2 + alpha-N-dichloroacetyl-p-aminophenylserinol + 2 O2 = A + chloramphenicol + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.99.67", "l": "\"alpha-N-dichloroacetyl-p-aminophenylserinol N-oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64323", "l": "(9Z)-hexadecenoyl-CoA + cholesterol <=> cholesteryl (9Z)-hexadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64793", "l": "L-lysine + NADP(+) => 2 H(+) + L-1-piperideine-6-carboxylate + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165195", "l": "GTP loading by Rheb (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015195", "l": "L-threonine transmembrane transporter activity", "d": ["Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60212", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + O2 = CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47696", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + H2O = (2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-glycerate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8849353", "l": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9604767", "l": "FLT3LG dimer:FLT3 dimer autophosphorylates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49806", "l": "FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine => 2-methylpropan-1-amine + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209765", "l": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28505", "l": "NAD(+) + S-(hydroxymethyl)mycothiol <=> H(+) + NADH + S-formylmycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9834070", "l": "PRKN ubiquitinates MOM substrates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10645", "l": "2-oxo-2H-pyran-4,6-dicarboxylate + H2O => (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25653", "l": "(2S)-2-amino-3-oxobutanoate + H(+) = aminoacetone + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389381", "l": "Gads binds CD28 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62488", "l": "1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12874", "l": "(R)-2-hydroxy-4-methylpentanoate + NADP(+) => 4-methyl-2-oxopentanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40137", "l": "(9Z)-tetradecenoate + CoA + H(+) => (9Z)-tetradecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9625828", "l": "FOXO1 binds RETN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981128", "l": "Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71803", "l": "acetate(out) + H(+)(out) = acetate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047297", "l": "asparagine-oxo-acid transaminase activity", "d": ["Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944684", "l": "miR-205 microRNA binds PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855182", "l": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45593", "l": "H2O + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352379", "l": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2509838", "l": "ITPA hydrolyses dITP to dIMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694462", "l": "ABHD6,12 hydrolyse 3AG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28284", "l": "(S)-beta-macrocarpene => (S)-beta-bisabolene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2768993", "l": "NOTCH1 PEST domain mutants bind JAG2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9629004", "l": "Transport of MCP:pPR-AP:pAP Complex into the Nucleous (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419981", "l": "Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24803", "l": "(S)-3-methyl-2-oxopentanoate + L-glutamate => 2-oxoglutarate + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72960", "l": "(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) => (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218855", "l": "BCAR1 binds p-7Y-PTK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40990", "l": "EDTA + 2 FMNH2 + 2 O2 <=> ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44373", "l": "Cr(6+) + 2 NADH + O2 => Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68878", "l": "AMP + diphosphate + NADP(+) + piperonal => ATP + H(+) + NADPH + piperonylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848316", "l": "IL36 binds IL1RL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202127", "l": "eNOS synthesizes NO (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78695", "l": "a ganglioside GA2 + UDP-alpha-D-galactose = a ganglioside GA1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61072", "l": "(-)-(R)-19-hydroxytabersonine + acetyl-CoA = (-)-(R)-19-O-acetyltabersonine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38105", "l": "2-dehydro-3-deoxy-L-galactonate + H2O => L-galactonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17725", "l": "(2S,3S)-2-methylcitrate = 2-methyl-cis-aconitate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.79", "l": "\"2-methylcitrate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983158", "l": "Trimming of peptides in ER (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74730", "l": "Insulin degradation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389424", "l": "The orphan QRFP receptor can bind neuropeptide QRFP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67984", "l": "N-acetyl-L-leucine = N-acetyl-D-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39755", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352914", "l": "glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77338", "l": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707504", "l": "H2O2 oxidises ferrohemoglobin to MetHb (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26562", "l": "2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.1.3.36", "l": "\"1,4-dihydroxy-2-naphthoyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419351", "l": "PAF receptor binds platelet activating factor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9728150", "l": "SLC5A2 binds gliflozins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25224", "l": "H(+) + L-cysteate <=> CO2 + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.70", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68615", "l": "Formation of ORC(1-6) complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30559", "l": "GTP + H2O = guanosine + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26472", "l": "16-feruloyloxyhexadecanoate + CoA => (E)-feruloyl-CoA + 16-hydroxyhexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014052", "l": "TXLNA (IL14) binds syntaxin3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25648", "l": "(2R,5R)-isomenthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140282", "l": "carbon-nitrogen ligase activity on lipid II", "d": ["Catalysis of the reaction: L-glutamine + lipid II + ATP + H2O = L-glutamate + beta-D-GlcNAc(1->4)-Mur2Ac(oyl-L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11468", "l": "(S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine", "d": [], "t": []}, {"i": "EC:2.6.1.32", "l": "\"valine--3-methyl-2-oxovalerate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16272", "l": "aniline + N,N-dimethyl-1,4-phenylenediamine + 2 NADP(+) <=> 4-(dimethylamino)azobenzene + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9866217", "l": "HCCS inserts heme into cytochrome c (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64648", "l": "(E)-coniferaldehyde + CoA + NADP(+) = (E)-feruloyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71010", "l": "MUT isomerises L-MM-CoA to SUCC-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015156", "l": "melibiose transmembrane transporter activity", "d": ["Enables the transfer of melibiose from one side of a membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3244643", "l": "STING binds cyclic GMP-AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9604480", "l": "NFkB complex translocates from the cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5602080", "l": "Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44790", "l": "H(+) + menaquinol-11 + S-adenosyl-L-homocysteine => 2-demethylmenaquinol-11 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14330", "l": "2-oxoglutarate + O-phospho-L-serine => 3-phosphooxypyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8940100", "l": "CDK1 phosphorylates VCPIP1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41884", "l": "dodecanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77402", "l": "hydrogen cyanide + pentanal <=> (2S)-2-hydroxyhexanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645766", "l": "p14ARF mutants do not bind C1QBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65940", "l": "(R)-glycerate + GDP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65327", "l": "acetyl-CoA + chrodrimanin A <=> chrodrimanin B + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36609", "l": "(2S,3S)-hydroxyarginine + CO2 + succinate => 2-oxoglutarate + L-arginine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31490", "l": "soyasapogenol B 3-O-beta-D-glucuronate + UDP-alpha-D-galactose <=> H(+) + soyasaponin III + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57989", "l": "(20S)-ginsenoside Rh2 + UDP-alpha-D-glucose => (20S)-ginsenoside F2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976723", "l": "Serum amyloid P-component forms homopentamers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66264", "l": "ATP + H(+) + nonanoate = diphosphate + nonanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60105", "l": "H(+) + indole-3-propanoate + oxidized [electron-transfer flavoprotein] => (E)-3-(indol-3-yl)acrylate + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21838", "l": "2-dehydro-3-deoxy-D-arabinonate + H2O => D-arabinonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654622", "l": "Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62046", "l": "(9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphoglycerol + H(+) => a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphoglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65992", "l": "calciol + hnu = 5,6-trans-vitamin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-169828", "l": "Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801762", "l": "REG3A oligomerize to form a pore complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50975", "l": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 <=> (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.57", "l": "\"butanal dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52088", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029680", "l": "Caspase-7 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202727", "l": "Integrin alphaMbeta2 (MAC1) binds JAM3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21988", "l": "malonyl-CoA + pelargonidin 3-O-(6-O-[(E)-caffeoyl]-beta-D-glucoside) 5-O-beta-D-glucoside = 4'''-demalonylsalvianin + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.172", "l": "\"anthocyanin 5-O-glucoside 6'''-O-malonyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65458", "l": "2-methylbutyl acetate + CoA => 2-methylbutan-1-ol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9611851", "l": "ADRB2 bind ADR,NAd (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59297", "l": "an N-acylglycine + 2 L-ascorbate + O2 => an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166544", "l": "TrkA receptor autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52789", "l": "chlorophyll a + 2 H(+) => Mg(2+) + pheophytin a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903876", "l": "11-deoxycortisol binding", "d": ["Binding to 11-deoxycortisol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8876484", "l": "NPC2 transfers CHOL to NPC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676940", "l": "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38978", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928625", "l": "PAKs autophosphorylate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654167", "l": "Activated FGFR1 binds PLCG1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0032357", "l": "oxidized purine DNA binding", "d": ["Binding to a DNA region containing an oxidized purine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097163", "l": "sulfur carrier activity", "d": ["Covalently binding to sulfur and delivering it to an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32866", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140833", "l": "RNA polymerase II CTD heptapeptide repeat Y1 kinase activity", "d": ["Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + RNA polymerase II large subunit phosphotyrosine (position 1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853793", "l": "p-5Y-RET complexes bind GRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54735", "l": "N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine <=> H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9907147", "l": "MITF-M-dependent IRF4 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22046", "l": "ADP + 2 H(+)(out) + K(+)(in) + phosphate => ATP + H(+)(in) + H2O + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031833", "l": "type 7 serotonin receptor binding", "d": ["Binding to a type 7 serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814674", "l": "Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202214", "l": "Dephosphorylation of Lck-pY505 by CD45 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198611", "l": "AKT phosphorylates IKKalpha (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58577", "l": "dihydroprecondylocarpine acetate + NADP(+) => H(+) + NADPH + precondylocarpine acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993781", "l": "Conjugation of SUMO3 to UBA2:SAE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8849085", "l": "ARHGAP35 binds RHOA:GTP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41909", "l": "(3R)-hydroxyhexadecanoyl-[ACP] => (2E)-hexadecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0061731", "l": "ribonucleoside-diphosphate reductase activity", "d": ["Catalysis of the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060703", "l": "deoxyribonuclease inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of deoxyribonuclease."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.4", "l": "\"anthocyanidin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47671", "l": "H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45868", "l": "9-decenoyl-CoA + 2 H(+) + 2 malonyl-CoA = 4-hydroxy-6-(non-8-en-1-yl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45275", "l": "12-phosphooxy-(9Z)-octadecenoate + H2O <=> 12-hydroxy-(9Z)-octadecenoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.042693372152272", "identifiers": [{"i": "GO:0016841", "l": "ammonia-lyase activity", "d": ["Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate."], "t": []}, {"i": "EC:4.3.1.-", "l": "\"Ammonia-lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-183126", "l": "Factor B binds to surface-associated C3b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49299", "l": "keto-L-sorbose(out) + N(pros)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + L-sorbose 1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951549", "l": "Carbocymycobactin binds Fe3+ from LTF:2xFe3+:2xCO3(2-) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5688797", "l": "ATXN3 family cleave Ub chains (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41106", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> (9Z)-octadecenoate + 1-hexadecanoyl-3-octadecanoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54034", "l": "(6S)-5,6,7,8-tetrahydrofolate + dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + H(+) => (6R)-10-formyltetrahydrofolate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34738", "l": "a fatty acyl-CoA + sphinganine <=> an N-acylsphinganine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12428", "l": "2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH = benzene-1,2,4-triol + NAD(+)", "d": [], "t": []}, {"i": "EC:1.6.5.7", "l": "\"2-hydroxy-1,4-benzoquinone reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.373103991056496", "identifiers": [{"i": "GO:0043169", "l": "cation binding", "d": ["Binding to a cation, a charged atom or group of atoms with a net positive charge."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30169", "l": "D-sedoheptulose 1,7-bisphosphate => D-erythrose 4-phosphate + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-169270", "l": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16934", "l": "1-aminocyclopropane-1-carboxylate + H2O => 2-oxobutanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5688834", "l": "ATXN3 binds VCP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170159", "l": "Translocation of Cdc25 to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047079", "l": "deoxyuridine 1'-dioxygenase activity", "d": ["Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O2 = 2-deoxy-D-ribono-1,4-lactone + CO2 + succinate + uracil."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683325", "l": "Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37416", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA => 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64493", "l": "3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] => dehydrocitreoisocoumarin + H2O + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70310", "l": "beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-dodecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68948", "l": "Ubiquitinated Orc1 is degraded by the proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432411", "l": "SLMB binds phosphorylated cytosolic PER, facilitating its ubiquitination (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614933", "l": "ACEIs bind ACE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264435", "l": "Dissociation of the COP1-p53 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858646", "l": "TCF/LEF:CTNNB1 binds the CCND1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177933", "l": "SHC1 phosphorylation by phosphorylated EGFR (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28701", "l": "Mn(2+)(out) => Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-109862", "l": "MAP2K2 phosphorylates MAPK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14257", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": [], "t": []}, {"i": "EC:2.4.1.152", "l": "\"4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371590", "l": "HSP70 binds to HSP40:nascent protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032267", "l": "tRNA(Ile)-lysidine synthase activity", "d": ["Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855381", "l": "PTPN22 dephosphorylates ZAP70 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15447", "l": "CO2 + 2 NH4(+) + pyruvate => H(+) + H2O + O-carbamoyl-L-serine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9033236", "l": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350901", "l": "Iodide is organified (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28244", "l": "5-hydroxypseudobaptigenin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => O2 + pratensein + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031697", "l": "beta-1 adrenergic receptor binding", "d": ["Binding to a beta-1 adrenergic receptor."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43053", "l": "3-(methylsulfanyl)propanoate + ATP + CoA => 3-(methylsulfanyl)propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.390", "l": "\"4,3-alpha-glucanotransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008496", "l": "mannan endo-1,6-alpha-mannosidase activity", "d": ["Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46717", "l": "pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-397891", "l": "Thrombin-activated PARs:G12/13 (active) dissociate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5668947", "l": "PAK1 phosphorylates myosin phosphatase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374248", "l": "Receptor CXCR3 binds ligands CXCL9 to 11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784436", "l": "An unknown carrier transports mitochondrial glyoxylate to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163568", "l": "phosphorylated perilipin + H2O -> perilipin + orthophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17035", "l": "biphenyl-2,3-diol + H(+) + NADH => (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52513", "l": "a quinone + trans-4-hydroxy-L-proline => (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3858495", "l": "DAAM1 recruits GTP-bound RHOA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959462", "l": "SAMD8 transfers phosphatidyl from PE onto C16DH CER (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50910", "l": "A + a 3-demethylubiquinol + H2O => a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69333", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+) => 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14915", "l": "adenosine + dTMP => AMP + thymidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65617", "l": "A + cholest-4-en-3-one + H2O => 25-hydroxycholest-4-en-3-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141208", "l": "protein lysine delactylase activity", "d": ["Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl-[protein] + NAD = L-lysyl-[protein] + nicotinamide +2''-O-lactoyl-ADP-D-ribose, removing a lactoyl group attached to a lysine residue in a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864577", "l": "TFAP2C translocates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75525", "l": "CoA + H(+) + N-acetyl-S-methyl-L-cysteine => acetyl-CoA + S-methyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9728150", "l": "SLC5A2 binds gliflozins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11844", "l": "acetyl-CoA + formate = CoA + pyruvate", "d": [], "t": []}, {"i": "EC:2.3.1.54", "l": "\"formate C-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45339", "l": "(9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine <=> [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23383", "l": "N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N,N'-diacetylchitobiosyl diphosphodolichol + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13173", "l": "H2O + NAD(+) + phosphonate = H(+) + NADH + phosphate", "d": [], "t": []}, {"i": "EC:1.20.1.1", "l": "\"phosphonate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-983266", "l": "Kinesins bind microtubules (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9630022", "l": "JMJD6 dimer hydroxylates lysine residues of U2AF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10778", "l": "3-(4-hydroxyphenyl)pyruvate + H(+) + NADPH => (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66940", "l": "acetyl-CoA + 22 H(+) + 11 malonyl-CoA + 12 NADPH + S-adenosyl-L-methionine = 12 CO2 + 12 CoA + 8 H2O + 12 NADP(+) + S-adenosyl-L-homocysteine + soppiline B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351876", "l": "Caspase-mediated cleavage of occludin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014424", "l": "RAC2 binds effectors at the phagocytic vesicle membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67124", "l": "a hydroperoxide + L-cysteinyl-[protein] = an alcohol + S-hydroxy-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44870", "l": "1,2-diacyl-sn-glycero-3-phosphoethanol + choline => a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113407", "l": "DSIF complex binds to RNA Pol II (hypophosphorylated) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37599", "l": "(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.13", "l": "\"acyl-CoA 15-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63849", "l": "2 2',3,4-trihydroxy-trans-chalcone + 2 H(+) + O2 => 2 3',4'-dihydroxyaurone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33127", "l": "H2O + salicin-6-phosphate = beta-D-glucose 6-phosphate + salicyl alcohol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65442", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-adenosine in mRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68435", "l": "lutein + O2 <=> (3R)-hydroxy-beta-ionone + (3R,6R)-3-hydroxy-10'-apo-alpha-carotenal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76551", "l": "acetyl-CoA + D-aspartate = CoA + H(+) + N-acetyl-D-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71427", "l": "3,3'-diiodo-L-thyronine(out) + an aromatic L-alpha-amino acid(in) = 3,3'-diiodo-L-thyronine(in) + an aromatic L-alpha-amino acid(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9823065", "l": "GPIb:IX:V binds to VWF multimer:collagen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.6", "l": "\"leghemoglobin reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950634", "l": "Expression of capping actin protein of muscle Z-line alpha subunit 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050469", "l": "sabinene-hydrate synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + H2O = diphosphate + sabinene hydrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28291", "l": "(2E,6E)-farnesyl diphosphate + H2O => (5S,9S,10S)-drim-7-en-11-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110308", "l": "REV1 inserts dCMP opposite to AP sites in DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64820", "l": "2-phenylacetamide + H2O = 2-phenylacetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51205", "l": "6-trans-leukotriene B4 + NADP(+) => 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203973", "l": "Vesicle budding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76438", "l": "(2S,9S)-annullatin H + 2 A <=> (2S,9S)-annullatin D + 2 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59219", "l": "(indol-3-yl)acetate + H(+) <=> CO2 + skatole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73553", "l": "GDP(in) + UTP(out) => GDP(out) + UTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080096", "l": "phosphatidate-sterol O-acyltransferase activity", "d": ["Catalysis of the reaction: a phosphatidate + a sterol = a sterol ester + a lysophosphatidate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56418", "l": "alpha-D-glucose 1-phosphate + glycerol => 2-O-(alpha-D-glucopyranosyl)glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14184", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 <=> (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31794", "l": "H2O + tuberculosinyl diphosphate <=> (13S)-edaxadiene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16647", "l": "CoA + H(+) + hexadecanoate => H2O + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70599", "l": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682983", "l": "ATM phosphorylates WHSC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60390", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]2} + H(+) => Fe(III)-di(C-5-deoxy-beta-D-glucosyl)-enterobactin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30521", "l": "diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine => GTP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17235", "l": "L-fuculose => L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093336", "l": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18976", "l": "2-oxoglutarate + deacetoxyvindoline + O2 <=> 4-O-deacetylvindoline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44133", "l": "2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine => 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205663", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71303", "l": "RPE dimers isomerise RU5P to XY5P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12412", "l": "(2R)-3-phosphoglycerate + H2O = (R)-glycerate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.38", "l": "\"3-phosphoglycerate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38744", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-375302", "l": "Kinetochore capture of astral microtubules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028735", "l": "AMOT proteins bind WWTR1 (TAZ) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784434", "l": "An unknown carrier transports cytosolic glyoxylate to the peroxisome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102497", "l": "scyllo-inositol dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: scyllo-inositol + NADP = 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202717", "l": "Heterodimerization of CEACAMs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683765", "l": "Nucleoprotein translocates to the ERGIC outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24468", "l": "H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0070004", "l": "cysteine-type exopeptidase activity", "d": ["Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052626", "l": "benzoate amino acid synthetase activity", "d": ["Catalysis of the reaction: benzoate + ATP + amino acid = benzoyl amino acid conjugate + AMP + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625841", "l": "Defective SLC24A1 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2314686", "l": "ASA- acetylates PTGS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875817", "l": "MET phosphorylates STAT3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59401", "l": "L-2-aminohexanoate => D-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53145", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-416929", "l": "PTGFR binds PGF2a (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687284", "l": "DMBT1 binds SFTPD 12mer, SFTPAs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43141", "l": "guanosine(26) in tRNA + 2 S-adenosyl-L-methionine => 2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227695", "l": "NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding. (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31493", "l": "H(+) + soyasaponin I + UDP => soyasaponin III + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43130", "l": "H(+) + N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine => guanosine(10) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27546", "l": "anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.14.14.8", "l": "\"anthranilate 3-monooxygenase (FAD)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420265", "l": "AMY1-3 bind IAPP(34-70) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209973", "l": "Tyrosine is diiodinated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.22.2", "l": "\"Aspergillus deoxyribonuclease K1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25269", "l": "(R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39566", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH <=> (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603784", "l": "PEX19:class I PMP binds PEX3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15922", "l": "2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59841", "l": "(6S)-5,6,7,8-tetrahydrofolate + syringate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-O-methylgallate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10483", "l": "2-oxoglutarate + 4-hydroxy-L-glutamate <=> 4-hydroxy-2-oxoglutarate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3828061", "l": "Defective GYS1 does not transfer glucose to growing glycogen chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9617927", "l": "FOXO4 binds ATXN3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23623", "l": "ATP + N(2)-(2-carboxyethyl)-L-arginine <=> AMP + deoxyamidinoproclavaminate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236938", "l": "Partial proteolysis of antigen in phagolysosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673231", "l": "GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0140666", "l": "annealing activity", "d": ["An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule."], "t": []}, {"i": "REACT:R-HSA-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990600", "l": "single-stranded DNA endodeoxyribonuclease activator activity", "d": ["Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2769015", "l": "NICD1 PEST domain mutants translocate from cytosol to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004487", "l": "methylenetetrahydrofolate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71164", "l": "HGD dioxygenates homogentisate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76365", "l": "n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(in) => n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioyl-D-alanyl-D-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050353", "l": "trimethyllysine dioxygenase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O2 = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO2 + succinate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111879", "l": "PIP2 hydrolysis (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74634", "l": "3-methyl-2-oxobutanoate + O-acetyl-L-homoserine <=> (6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022398", "l": "ACE:Zn2+ hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9748963", "l": "GUK1 phosphorylates 6TdGMP to 6TdGDP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66897", "l": "4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170131", "l": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602398", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[16] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15471", "l": "5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29064", "l": "a menaquinone + formate + H(+) => a menaquinol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786205", "l": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35606", "l": "beta-D-fructose 1-phosphate + H2O <=> D-fructose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73316", "l": "1D-chiro-inositol(out) + 2 Na(+)(out) => 1D-chiro-inositol(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45932", "l": "2-methylhexadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(3-methyl-2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685607", "l": "Sialic acid binds SIGLEC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6801342", "l": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56808", "l": "ATP + cob(I)yrinate a,c diamide-[corrinoid adenosyltransferase] = adenosylcob(III)yrinate a,c-diamide + apo-[corrinoid adenosyltransferase] + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395873", "l": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975185", "l": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23506", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate => adenosylcob(III)inamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67596", "l": "heptadecasphing-4-enine + octadecanoyl-CoA = CoA + H(+) + N-octadecanoyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0016632", "l": "oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome."], "t": []}, {"i": "EC:1.3.2.-", "l": "\"With a cytochrome as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44858", "l": "CoA + O-(9Z)-octadecenoyl-(R)-carnitine => (9Z)-octadecenoyl-CoA + (R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863494", "l": "ASICs bind STOML3, (STOM) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-383313", "l": "Glucagon-like Peptide 1 is secreted from intestinal L cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9612501", "l": "SGK phosphorylates CREB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n7", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.32", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27613", "l": "formate + H(+) <=> CO2 + H2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5252041", "l": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983374", "l": "p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73810", "l": "FGAM + ATP => AIR + ADP + Pi (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42302", "l": "a 1-acyl-sn-glycero-3-phosphate + holo-[ACP] => a fatty acyl-[ACP] + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11302", "l": "2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH => 1D-5-O-methyl-myo-inositol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839384", "l": "Inhibin-A binding to TGFBR3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24418", "l": "4-hydroxybenzoate + formate + 2 H(+) => 2,4'-dihydroxyacetophenone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14554", "l": "(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate => 2-oxoglutarate + cephalosporin C", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937814", "l": "RUNX3 translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69604", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629492", "l": "NEIL3 cleaves spiroiminodihydantoin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49553", "l": "H2O + N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] => H(+) + L-lysyl-[protein] + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839146", "l": "YME1L1 degrades mitochondrial inner membrane proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2471842", "l": "Collagen type XXV ectomain shedding (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-68611", "l": "Formation of ORC(1-5) complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449803", "l": "IL10 dimer binds IL10RA:JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38323", "l": "2 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70692", "l": "ornithine => putrescine + CO2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112604", "l": "Phosphorylated STATs are released (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-372843", "l": "SLC25A10 mediates exchange of malate and phosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726949", "l": "PTGIR binds PTGIR agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.65", "l": "\"(d)CTP diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29437", "l": "enterobactin(out) + H(+)(in) => enterobactin(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432849", "l": "S100A8:S100A9 binds TLR4:LY96 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482548", "l": "1-acyl LPA is acylated to PA by AGPAT5 (OM) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9822583", "l": "METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19967", "l": "acrylate + dimethyl sulfide + H(+) => S,S-dimethyl-beta-propiothetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.33", "l": "\"N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862771", "l": "PLA2G2A binds bacterial phospholipids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046558", "l": "arabinan endo-1,5-alpha-L-arabinosidase activity", "d": ["Catalysis of the endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5) arabinans."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762333", "l": "ANGPTL4 binds to CDH11v (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749351", "l": "CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71586", "l": "L-histidine(in) + Na(+)(in) <=> L-histidine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-727819", "l": "TAK1 phosphorylates MKK6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940554", "l": "MMP2 cleaves OPTC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9648268", "l": "HTR1A binds HTR1A antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48044", "l": "ganglioside GM1 (d18:1(4E)/18:0) + H2O = D-galactose + ganglioside GM2 (d18:1(4E)/18:0)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.23", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24406", "l": "acetoacetate + acetyl-CoA => (3S)-hydroxy-3-methylglutaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717396", "l": "SCN2A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9818789", "l": "CHUK, IKBKB phosphorylate RIPK1 at S25 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-199032", "l": "MADCAM1-1 binds Integrin alpha4beta7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627107", "l": "XIAP binds CASP7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38790", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z)-octadecenoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78756", "l": "alpha-L-rhamnosyl-(1->4)-D-glucuronate => 4-deoxy-L-threo-hex-4-enopyranuronate + L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809140", "l": "IL35 binds IL-12RB2:IL6ST receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68666", "l": "17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 17beta-estradiol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65308", "l": "an ultra-long-chain di-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxo-ultra-long-chain di-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}, {"i": "EC:2.3.1.294", "l": "\"meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37919", "l": "(9Z,12Z)-octadecadienoate + O2 = (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27759", "l": "(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) => (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + CO2 + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28076", "l": "(2R)-3-sulfolactate + 3 H(+) + 2 NADH => (2R)-3-sulfopropanediol + H2O + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42190", "l": "5alpha-androstan-3,17-dione + H(+) + NADH => 3beta-hydroxy-5alpha-androstan-17-one + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53786", "l": "beta-muricholoyl-CoA + deoxycholate => beta-muricholate + deoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855564", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45049", "l": "acetamide + H2O => acetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640195", "l": "RRAGA,B hydrolyzes GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755015", "l": "SLC29A1 transports RBV from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932633", "l": "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877361", "l": "Pyrin binds ASC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26471", "l": "(E)-feruloyl-CoA + 16-hydroxyhexadecanoate => 16-feruloyloxyhexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24739", "l": "(6R)-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) => 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.31", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39032", "l": "a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-Glc-(1->6)-beta-D-Glc)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1237119", "l": "Acireductone is oxidized to MOB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.46", "l": "\"pyrimidine monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15033", "l": "O2 + pyridoxine = H2O2 + pyridoxal", "d": [], "t": []}, {"i": "EC:1.1.3.12", "l": "\"pyridoxine 4-oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0005186", "l": "pheromone activity", "d": ["The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5653873", "l": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354066", "l": "Translocation of PTK2 to Focal complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.83", "l": "\"kappa-carrageenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788623", "l": "p-Y-STATs translocate to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47148", "l": "a ubiquinone + caffeine + H2O = 1,3,7-trimethylurate + a ubiquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2197562", "l": "NOTCH2 stimulates HES1 transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34632", "l": "5beta-cholestane-3alpha,7alpha,12alpha-triol + 5 H(+) + 3 O2 + 6 reduced [adrenodoxin] => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + 4 H2O + 6 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.-", "l": "\"Dipeptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50670", "l": "an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+) => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809140", "l": "IL35 binds IL-12RB2:IL6ST receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48319", "l": "a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GD1alpha + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75079", "l": "Formation of AT-AC C complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14051", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-ol => O2 + reduced [NADPH--hemoprotein reductase] + taxa-4,11-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9851407", "l": "FAM83B, (FAM83A, FAM83D) bind EGFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733960", "l": "Bile salts and acids dissociate from ALB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64526", "l": "2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] => (2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + AH2 + 3 H(+) + 4 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64530", "l": "2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + A + 4 CO2 + 4 CoA + H2O + holo-[ACP] + S-adenosyl-L-homocysteine => AH2 + decanoyl-[ACP] + 3 H(+) + 4 malonyl-CoA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419334", "l": "Melatonin receptors can bind melatonin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022141", "l": "Prolysyl oxidase activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74754", "l": "dodecapentaneoyl-[polyketide synthase] + fumagillol <=> holo-[polyketide synthase] + prefumagillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70541", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+) => GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31263", "l": "but-3-ynal + H(+) + pyrroloquinoline quinol = but-3-yn-1-ol + pyrroloquinoline quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70140", "l": "6-deoxo-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha-hydroxy-28-nortyphasterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620828", "l": "FOXO1,FOXO3,(FOXO4) binds CCNG2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67554", "l": "adenosine 3',5'-bisphosphate + cholate 7-sulfate + H(+) => 3'-phosphoadenylyl sulfate + cholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211991", "l": "Cyclophosphamide is 4-hydroxylated by CYP2B6 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15944", "l": "H2O + N(2)-acetyl-L-ornithine <=> acetate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63445", "l": "(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin => GMP + H(+) + oxidized coenzyme F420-0", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43236", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72588", "l": "(E)-sinapate + ATP + CoA => (E)-sinapoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067676", "l": "IL6:IL6R-2 binds IL6ST-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42339", "l": "[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29276", "l": "L-isoleucine(in) + Na(+)(in) => L-isoleucine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51548", "l": "(S)-tetrahydropapaverine + S-adenosyl-L-methionine = (S)-N-methyltetrahydropapaverine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77442", "l": "a ganglioside GQ1c + H2O <=> a ganglioside GT1c + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11681", "l": "ATP + H2O + L-glutamine + XMP => AMP + diphosphate + GMP + 2 H(+) + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102847", "l": "1-18:3-2-16:2-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939801", "l": "26S proteasome degrades PolyUb-RUNX2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0033765", "l": "steroid dehydrogenase activity, acting on the CH-CH group of donors", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008389", "l": "RUNX2 binds HDAC6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33741", "l": "H2O + hexadecanal + NAD(+) => 2 H(+) + hexadecanoate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201486", "l": "ALK binds ligand pleiotrophin (PTN) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30303", "l": "(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.95", "l": "\"germacrene A hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73424", "l": "L-asparagine(out) => L-asparagine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16031", "l": "beta-alanine + urea => 3-guanidinopropanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008791", "l": "arginine N-succinyltransferase activity", "d": ["Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9638064", "l": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551465", "l": "Translocation of NFATC1:CaN:CaM to nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9036987", "l": "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16121", "l": "5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13200", "l": "H(+) + sulfite + UDP-alpha-D-glucose <=> H2O + UDP-alpha-D-6-sulfoquinovose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38714", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol <=> (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29943", "l": "2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) = 2-dehydro-3-deoxy-D-gluconate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67427", "l": "a glycerophospholipid + H2O <=> a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.66", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051508", "l": "stigmasterol UDP-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + stigmasterol = UDP + O-glucosyl-stigmasterol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17037", "l": "indole-3-ethanol + NADP(+) = H(+) + indole-3-acetaldehyde + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.191", "l": "\"indole-3-acetaldehyde reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37213", "l": "guanosine 2'-phosphate + H(+) => 2',3'-cyclophospho-GMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3325546", "l": "Defective CD320 does not transport extracellular TCII:Cbl to endosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30227", "l": "dimethyl sulfide + 2 Fe(III)-[cytochrome c2] + H2O = dimethyl sulfoxide + 2 Fe(II)-[cytochrome c2] + 2 H(+)", "d": [], "t": []}, {"i": "EC:1.8.2.4", "l": "\"dimethyl sulfide:cytochrome c2 reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856189", "l": "TNFSF8 binds TNFRSF8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018829", "l": "1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity", "d": ["Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000405", "l": "bubble DNA binding", "d": ["Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848582", "l": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69567", "l": "12 ATP + L-asparagine + L-aspartate + L-cysteine + L-glutamate + L-histidine + 3 L-isoleucine + L-leucine + L-lysine + L-ornithine + L-phenylalanine <=> 12 AMP + bacitracin A + 12 diphosphate + 12 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66241", "l": "ATP + CoA + IC-asc-C9 => AMP + diphosphate + IC-asc-C9-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0008920", "l": "lipopolysaccharide heptosyltransferase activity", "d": ["Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9692539", "l": "HRH1 binds HRH1 inverse agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351913", "l": "Caspase-mediated cleavage of TJP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68736", "l": "ganoderate TR + O2 + reduced [NADPH--hemoprotein reductase] = ganoderate Jc + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019981", "l": "interleukin-6 binding", "d": ["Binding to interleukin-6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036729", "l": "Defective GAA does not hydrolyze lysosomal glycogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41153", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+) => 1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49468", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-6-sulfoquinovose = a 6-sulfo-alpha-D-quinovosyldiacylglycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16833", "l": "2 glutathione + H2O2 = glutathione disulfide + 2 H2O", "d": [], "t": []}, {"i": "EC:1.11.1.9", "l": "\"glutathione peroxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607755", "l": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19782", "l": "2-oxoglutarate + 3,5-diiodo-L-tyrosine => 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31332", "l": "ATP + H(+) + molybdopterin => adenylyl-molybdopterin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77964", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (5R,12R,14S)-dolasta-1(15),8-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-749454", "l": "The Ligand:GPCR:Gi complex dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381186", "l": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5696872", "l": "USP30 deubiquitinates Ub-MOM proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997263", "l": "JMJD1C demethylates H3K9 mono- and di-methylation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987052", "l": "p-STAT3 dimer translocates from cytosol to nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76679", "l": "CoA + NAD(+) + sulfoacetaldehyde = H(+) + NADH + sulfoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39888", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + 2 oxidized [2Fe-2S]-[ferredoxin] + pikromycin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0008331", "l": "high voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004766", "l": "spermidine synthase activity", "d": ["Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57894", "l": "a quinol + 4 H(+)(out) + NADP(+) => a quinone + 5 H(+)(in) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14970", "l": "S-adenosyl-L-methionine + trans-aconitate => (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71961", "l": "3 Na(+)(in) + oxaloacetate(in) => 3 Na(+)(out) + oxaloacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23282", "l": "CoA + S-acetylcysteamine => acetyl-CoA + cysteamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376141", "l": "Interaction of ABL with ROBO1:SLIT2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42502", "l": "6-lactoyl-5,6,7,8-tetrahydropterin + H(+) + NADPH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13851", "l": "D-ribulose => D-arabinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227753", "l": "Caspase 8 or 10 recruitment to IPS1 complex followed by their dimerization (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975142", "l": "Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0005310", "l": "dicarboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67582", "l": "adenosine 3',5'-bisphosphate + H(+) + tauro-alpha-muricholate 7-sulfate => 3'-phosphoadenylyl sulfate + tauro-alpha-muricholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50173", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62569", "l": "H2O + S-benzyl-L-cysteinylglycine => glycine + S-benzyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54566", "l": "a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+) => a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65083", "l": "asperaculane D + O2 + reduced [NADPH--hemoprotein reductase] <=> asperaculane E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446322", "l": "PARVA associates with Paxillin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49365", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + H(+) => 17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010013", "l": "N-1-naphthylphthalamic acid binding", "d": ["Binding to N-1-naphthylphthalamic acid, an auxin transport inhibitor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56097", "l": "[protein]-C-terminal Gly-Gly + ATP + H(+) => [protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34165", "l": "(2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+) => hydroquinone + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23723", "l": "ATP + hydrogencarbonate + propanoyl-CoA <=> (S)-methylmalonyl-CoA + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161692", "l": "15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714580", "l": "SLC6A3 binds DRIs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912496", "l": "Formation of meiotic holliday junction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193460", "l": "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855617", "l": "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-430135", "l": "p-SLP-76 binds ADAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.52", "l": "\"trimerelysin I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912467", "l": "BRCA1 is recruited to unsynapsed regions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26286", "l": "Co-precorrin-5B + S-adenosyl-L-methionine => Co-precorrin-6A + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372705", "l": "Recruitment of BCAR1 to PTK2 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35752", "l": "ATP + kanosamine => ADP + D-kanosamine 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705714", "l": "SRD5A3 dehydrogenates TEST to DHTEST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376369", "l": "Vamp2 associated secretory vesicle to plasma membrane transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875659", "l": "RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236970", "l": "Proteasomal clevage of exogenous antigen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672973", "l": "MAP2Ks phosphorylate MAPKs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750942", "l": "USP14 deubiquitinates NLRC5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013963", "l": "RIP3 binds TICAM1 within TLR3 complex to mediate necroptosis  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53070", "l": "4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP => 4-methoxyestrone + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55003", "l": "3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32693", "l": "(E)-beta-ocimene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24315", "l": "L-lysyl-[cytochrome c] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl-[cytochrome c] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000036", "l": "acyl carrier activity", "d": ["Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980130", "l": "NOTCH1 binds DLK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36603", "l": "2-oxoglutarate + L-enduracididine + O2 = (3S)-3-hydroxy-L-enduracididine + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.40", "l": "\"enduracididine beta-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64046", "l": "CoA + H(+) + N-(13Z-docosenoyl)-sphing-4-enine => (13Z)-docosenoyl-CoA + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170861", "l": "Dimeric TGF-beta-1 binds to the receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34641", "l": "H2O + NADP(+) + neopentalenolactone D => 1-deoxy-11-oxopentalenate + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69959", "l": "6-deoxoteasterone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxyteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61979", "l": "glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65526", "l": "9-cis-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 9-cis-retinal + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811423", "l": "Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3240777", "l": "E2F1/2/3:DP1/2 binds EZH2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013471", "l": "MPST transfers sulfur from 3MPYR to HCN to form HSCN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72621", "l": "Ribosomal scanning  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8877692", "l": "PIN1 binds phosphorylated PIP4K2B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983299", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634897", "l": "NPAS4 binds CDK5R1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809808", "l": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-212252", "l": "Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74639", "l": "AMP(out) + CMP-N-acetyl-beta-neuraminate(in) = AMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22844", "l": "(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + O2 + reduced [NADPH--hemoprotein reductase] = glyceollin I + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047330", "l": "polyphosphate-glucose phosphotransferase activity", "d": ["Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0170054", "l": "ribonuclease activator activity", "d": ["Binds to and increases the activity of a ribonuclease."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-216068", "l": "Interaction of integrin alpha9beta1 with Tenascin-C (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74177", "l": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32101", "l": "DIMBOA beta-D-glucoside + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + TRIBOA beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9648089", "l": "NEK6 and NEK7 phosphorylate EML4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51122", "l": "(8S,15S)-dihydroxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 A + 2 H2O => (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate + 2 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4084994", "l": "NEU3 hydrolyzes Neu5Ac from glycoconjugates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69758", "l": "(2-aminobenzyl)malonyl-CoA + H(+) + O2 <=> (E)-2-aminocinnamoyl-CoA + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9796346", "l": "MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193695", "l": "IRAK interacts with TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74214", "l": "H2O + L-threonyl-tRNA(Lys) <=> L-threonine + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33955", "l": "DIBOA + UDP-alpha-D-glucose = DIBOA beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40382", "l": "1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP <=> 1-octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73901", "l": "ADP + gamma-L-glutamylcadaverine + H(+) + phosphate => ATP + cadaverine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52728", "l": "3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate = a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432010", "l": "Aquaporin-1 passively transports water into cell (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72860", "l": "3',3',3'-c-tri-AMP + H2O => A[3'-5']pA[3'-5']pAp[3'] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869425", "l": "PLA1A hydrolyses PS to 2-acyl LPS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102614", "l": "germacrene A acid 8beta-hydroxylase activity", "d": ["Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + NADPH + O2 + H+ = 8beta-hydroxy-germacra-1(10),4,11(13)-trien-12-oate + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68407", "l": "(2R,3S)-iso(homo)2citrate + NAD(+) <=> 2-oxoheptanedioate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16722", "l": "5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) => 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853745", "l": "RET binds GFRA1,GFRA3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46566", "l": "acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+) => acetyl-CoA + apo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4793925", "l": "p-S303,307-HSF1 binds YWHAE (14-3-3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012203", "l": "miR-26A and B bind to the 3'UTR of the CHD11 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "77.354970481220079", "identifiers": [{"i": "GO:0008641", "l": "ubiquitin-like modifier activating enzyme activity", "d": ["Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9860264", "l": "TASL is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111955", "l": "cAMP hydrolysis by Cam-PDE 1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45078", "l": "(9Z,12Z)-18-hydroxyoctadecadienoyl-CoA + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoyl-CoA + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27909", "l": "butanoyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5674385", "l": "p-T,Y MAPKs dimerize (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033850", "l": "Z-farnesyl diphosphate synthase activity", "d": ["Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans-farnesyl diphosphate + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61322", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + parthenolide => (+)-costunolide + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028294", "l": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168893", "l": "Binding of NEP/NS2 to vRNP:M1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3296326", "l": "HCAR1 binds LACT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9760081", "l": "CREBBP, EP300 acetylates NFE2L2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49750", "l": "CO2 + 2 H2O + NADP(+) + proviolacein => 2 H(+) + NADPH + 2 O2 + protodeoxyviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937807", "l": "SRC phosphorylates RUNX3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63626", "l": "AMP + H(+) + hexadecanoyl-[ACP] => hexadecanoyl-AMP + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222376", "l": "NOX2 generates superoxide from oxygen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236949", "l": "Translocation of antigenic peptides back to phagosomes via TAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23934", "l": "an N-acyl-D-mannosamine 6-phosphate => an N-acyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0052856", "l": "NADHX epimerase activity", "d": ["Catalysis of the reaction: (R)-NADHX = (S)-NADHX."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015361", "l": "low-affinity sodium:dicarboxylate symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}, {"i": "REACT:R-HSA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17842", "l": "trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050566", "l": "asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity", "d": ["Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54591", "l": "S-adenosyl-L-methionine + uridine in 25S rRNA <=> H(+) + N(3)-methyluridine in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19870", "l": "an acyl-CoA + glycine => an N-acylglycine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796379", "l": "CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28163", "l": "cytidine + GTP => CMP + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183089", "l": "CBL binds and ubiquitinates phosphorylated Sprouty (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62861", "l": "acetyl-CoA + 7 H(+) + 7 malonyl-CoA => 7,9,10-trihydroxy-3-(2-oxopropyl)-1H-benzo[g]isochromen-1-one + 7 CO2 + 8 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10287", "l": "L-leucine <=> (3R)-beta-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28793", "l": "H(+) + NADH + thymine => 5,6-dihydrothymine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943040", "l": "HLTF polyubiquitinates monoubiquitinated PCNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49848", "l": "(-)-dehydrodiconiferyl acid ketone + a quinone + H2O = (-)-dehydrodiconiferyl acid carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33996", "l": "gamma-L-glutamyl-butirosin B => 5-oxo-L-proline + butirosin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38421", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate => 1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44347", "l": "ATP + L-valine + N(3)-fumaramoyl-(S)-2,3-diaminopropanoate <=> ADP + dapdiamide A + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047236", "l": "methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity", "d": ["Catalysis of the reaction: methylazoxymethanol + UDP-D-glucose = H+ + cycasin + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687464", "l": "MRN and RBBP8 resect DNA DSBs in MMEJ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54679", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> (+)-kolavenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40945", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72612", "l": "H(+)(out) + L-alanyl-L-lysine(out) => H(+)(in) + L-alanyl-L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190541", "l": "Association of Cx43 with TJP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33590", "l": "acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate <=> CoA + H(+) + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031771", "l": "type 1 orexin receptor binding", "d": ["Binding to a type 1 orexin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38407", "l": "1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = (9Z,12Z)-octadecadienoate + 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42643", "l": "a 2-demethylmenaquinol + S-adenosyl-L-methionine <=> a menaquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65759", "l": "2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] <=> (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009673", "l": "low-affinity phosphate transmembrane transporter activity", "d": ["Enables the transfer of phosphate from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008511", "l": "sodium:potassium:chloride symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.14", "l": "\"cytosol alanyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686642", "l": "RAD52 promotes single strand annealing at resected DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22506", "l": "adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3'-bissulfate => 3'-phosphoadenylyl sulfate + quercetin 3-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797962", "l": "DMGLY translocates from cytosol to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51181", "l": "cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine => 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450550", "l": "PKCalpha phosphorylates HuR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112429", "l": "Formation of FACT complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865275", "l": "PDGF-BB clevage by Furin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39300", "l": "(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863463", "l": "STON2 binds SYT proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110376", "l": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005503", "l": "all-trans retinal binding", "d": ["Binding to all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55764", "l": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-187948", "l": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322016", "l": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20322", "l": "L-proline + NAD(+) => 1-pyrroline-2-carboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114254", "l": "CYCS binds to APAF1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247922", "l": "GGCT transforms gGluCys to OPRO (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67018", "l": "a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + L-lysyl-[protein] => a 5'-end diphospho-ribonucleoside in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3247847", "l": "WLS is endocytosed to the early endosome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708292", "l": "DICER1 cleaves tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74695", "l": "(+)-exo-beta-bergamotene + O2 + reduced [NADPH--hemoprotein reductase] = (5R)-hydroxy-beta-trans-bergamotene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39093", "l": "(3S)-hydroxydecanedioyl-CoA => (2E)-decenedioyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8865454", "l": "CBFB binds RUNX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8948136", "l": "ULK1 Translocates to the mitochondria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14194", "l": "3-hydroxybenzoate + AH2 + O2 => 2,3-dihydroxybenzoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-981728", "l": "Factor H binds to membrane-associated C3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034812", "l": "9,10-dihydroxybenzo(a)pyrene dioxygenase activity", "d": ["Catalysis of the reaction: 9,10-dihydroxybenzo(a)pyrene + O2 = cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48256", "l": "(2S)-2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.41", "l": "\"atrolysin B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936519", "l": "NQO2:FAD dimer reduces quinones to hydroquinones (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25192", "l": "chloroacetate + H2O <=> chloride + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8874083", "l": "p-Y397-PTK2 binds SRC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-205136", "l": "GTP-bound RAC contributes to JNK activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684140", "l": "ATM phosphorylates RBBP8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944261", "l": "Association of procollagen type XIII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15804", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O <=> a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63729", "l": "candesartan + UDP-alpha-D-glucuronate => candesartan-2-N-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48672", "l": "20-oxo-leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31825", "l": "cubebol + diphosphate => (2E,6E)-farnesyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64432", "l": "H(+)(out) + L-alanyl-L-prolylglycine(out) = H(+)(in) + L-alanyl-L-prolylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015018", "l": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.221", "l": "\"peptide-O-fucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952399", "l": "Polyubiquitinated RUNX3 translocates to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8873794", "l": "PCTP binds PC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51432", "l": "(S)-1-aminoethylphosphonate + acetyl-CoA = [(1S)-1-acetamidoethyl]phosphonate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29639", "l": "D-maltohexaose + H2O = alpha-D-glucose + D-maltopentaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708759", "l": "DHODH:FMN binds DHODH inhibitors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.183", "l": "\"glycoprotein-mannosyl O(6)-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55186", "l": "2-hydroxy-3-methylundecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylundecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200676", "l": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53826", "l": "7-oxotaurolithocholate + H(+) + NADH => NAD(+) + taurochenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27365", "l": "bromide + S-adenosyl-L-methionine = bromomethane + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-77333", "l": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951966", "l": "EP300 acetylates RUNX3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45314", "l": "H(+) + NADPH + prostaglandin H2 => NADP(+) + prostaglandin F2alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23943", "l": "D-gluconate + NAD(+) <=> 5-dehydro-D-gluconate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60783", "l": "2-oxoglutarate + gibberellin A15 + O2 <=> CO2 + gibberellin A24 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11849", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine => [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25002", "l": "(E)-phenylacetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37591", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170159", "l": "Translocation of Cdc25 to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19705", "l": "CoA + hexadecanal + NAD(+) = H(+) + hexadecanoyl-CoA + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.42", "l": "\"hexadecanal dehydrogenase (acylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19371", "l": "H(+) + N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine => L-histidyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22510", "l": "diphosphate + DNA(n+1) => a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.48", "l": "\"sucrose alpha-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78864", "l": "a short-chain (3R)-hydroxy fatty acyl-CoA => a short-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18867", "l": "CoA + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] => 2-methylpropanoyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141423", "l": "Binding of the MCC complex to the APC/C complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11527", "l": "5beta-cholestan-3-one + NADP(+) <=> cholest-4-en-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717658", "l": "SARS-CoV-2 N binds DDX58 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013147", "l": "RAC1 GDIs block activation of RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5195402", "l": "CDK1 phosphorylates LPIN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39707", "l": "a long-chain fatty acyl-CoA(out) = a long-chain fatty acyl-CoA(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1169398", "l": "ISGylation of host protein filamin B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655243", "l": "Activated FGFR3 point and translocation mutants phosphorylate PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63546", "l": "kinetensin-(1-8) + L-leucine => H2O + kinetensin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6784423", "l": "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64146", "l": "(9Z)-octadecenoate + L-methionine => H2O + N-(9Z-octadecenoyl)-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950398", "l": "CANX dissociates from IL27:EBI3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5226999", "l": "ADD1:ADD3 binds DMTN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39509", "l": "(3R)-hydroxy-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + NADP(+) => 3-oxo-(15Z,18Z,21Z,24Z,27Z)-triacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25979", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52793", "l": "chlorophyllide a + 2 H(+) => Mg(2+) + pheophorbide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.042693372152272", "identifiers": [{"i": "GO:0016885", "l": "ligase activity, forming carbon-carbon bonds", "d": ["Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}, {"i": "EC:6.4.-.-", "l": "\"Forming carbon-carbon bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31117", "l": "biotinyl-5'-AMP + diphosphate => ATP + biotin + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58579", "l": "dihydroprecondylocarpine acetate + NADP(+) <=> H(+) + NADPH + precondylocarpine acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21839", "l": "D-arabinonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799409", "l": "HIPK2 phosphorylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5666088", "l": "RHOD:GTP recruits DAIPH2-3 to endosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47210", "l": "2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => estrone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37499", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917835", "l": "Fe3+ dissociates from holoTF:TFRC dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49293", "l": "D-cellobiose(out) + N(pros)-phospho-L-histidyl-[protein] => 6-phospho-beta-D-glucosyl-(1->4)-D-glucose(in) + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12260", "l": "ATP + NADH = ADP + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:2.7.1.86", "l": "\"NADH kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0141050", "l": "histone H3K deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine + H2O = histone H3 L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone H3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9717206", "l": "L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67363", "l": "H2O + L-threonyl-L-threonine <=> 2 L-threonine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61178", "l": "CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside] => (E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55075", "l": "2-oxobutanoate + H(+) <=> CO2 + propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34927", "l": "H(+) + NADPH + selenodiglutathione = glutathione + glutathioselenol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13698", "l": "ATP + D-ribose => ADP + D-ribose 5-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-143468", "l": "MEOS oxidizes ethanol to acetaldehyde (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54799", "l": "a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) <=> an (R)-2-alkyl-3-oxoalkanoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070005", "l": "cysteine-type aminopeptidase activity", "d": ["Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.2.-", "l": "\"Phosphotransferases with a carboxy group as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-176298", "l": "Activation of claspin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5626316", "l": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78048", "l": "1-O-alkyl-2-acetylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine => 1-O-alkyl-2-acetyl-3-acylglycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9626817", "l": "PKC phosphorylates NCF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55858", "l": "all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57005", "l": "acetyl-CoA + streptothricin D => CoA + H(+) + N(beta)-acetylstreptothricin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13874", "l": "(+)-copalyl diphosphate => abieta-7,13-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49440", "l": "(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA = (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate", "d": [], "t": []}, {"i": "EC:2.8.3.24", "l": "\"(R)-2-hydroxy-4-methylpentanoate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46647", "l": "cortisol + H(+) + NADPH <=> 5beta-dihydrocortisol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13125", "l": "CoA + glutathione disulfide = CoA-glutathione + glutathione", "d": [], "t": []}, {"i": "EC:1.8.4.3", "l": "\"glutathione--CoA-glutathione transhydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24606", "l": "H(+) + S-adenosyl-L-homocysteine + theobromine => 7-methylxanthine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32764", "l": "(3R)-3-methyl-D-ornithine + ATP + L-lysine => (3R)-3-methyl-D-ornithyl-N(6)-L-lysine + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45007", "l": "(R)-carnitine + 2,6-dimethylheptanoyl-CoA <=> CoA + O-2,6-dimethylheptanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163741", "l": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54252", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23700", "l": "(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)", "d": [], "t": []}, {"i": "EC:3.5.4.9", "l": "\"methenyltetrahydrofolate cyclohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66899", "l": "4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] <=> 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876837", "l": "RAB21 GEFs exchange GTP for GDP on RAB21 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649802", "l": "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9754964", "l": "ADA deamidates RBV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46711", "l": "2-hydroxybenzoyl-5'-AMP + holo-[ACP] <=> AMP + H(+) + salicyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982775", "l": "Growth hormone receptor dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2219524", "l": "PDPK1 binds PIP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425861", "l": "Activation of Protein Kinase C novel isoforms (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0019966", "l": "interleukin-1 binding", "d": ["Binding to interleukin-1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380272", "l": "Plk1-mediated phosphorylation of Nlp (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033415", "l": "UGA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77979", "l": "all-trans-hexaprenyl diphosphate + H2O = colleterpenol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.213", "l": "\"colleterpenol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41721", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + a 2-acyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22932", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.38", "l": "\"beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0015924", "l": "mannosyl-oligosaccharide mannosidase activity", "d": ["Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62656", "l": "2,3,4,7,9-pentahydroxy-6-methyl-1H-phenalen-1-one + dimethylallyl diphosphate = 2,4,7,9-tetrahydroxy-6-methyl-8-(2-methylbut-3-en-2-yl)-1-oxo-1H-phenalen-3-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.8.1.8", "l": "\"N-(sulfonatooxy)prop-2-enimidothioate sulfolyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163099", "l": "Alignment Of The RNA Template On The Telomeric Chromosome End (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64251", "l": "decanoyl-CoA + glycine <=> CoA + H(+) + N-decanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.182", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-180073", "l": "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29648", "l": "alpha-maltopentaose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltotetraose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13086", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O => CoA + L-2-acetamido-6-oxoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9032021", "l": "RvT1-4 translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43586", "l": "5-guanidino-2-oxopentanoate + NH4(+) => H2O + iminoarginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0072545", "l": "L-tyrosine binding", "d": ["Binding to L-tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2255343", "l": "RAB8A,10,13,14 exchange GDP for GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53137", "l": "(3beta,5alpha,17beta)-3-hydroxy-androstan-17-yl sulfate + NADP(+) => 5alpha-dihydrotestosterone sulfate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0140906", "l": "halogenase activity", "d": ["Catalysis of the reaction: R-CH + a halogen + oxygen donor = R-C-halogen +H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10340", "l": "(2E,6E)-farnesyl diphosphate = (-)-vetispiradiene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.21", "l": "\"vetispiradiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76761", "l": "1,5-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0052736", "l": "beta-glucanase activity", "d": ["Catalysis of the hydrolysis of linkages in beta-D-glucans; beta-glucans are polysaccharides of D-glucose monomers linked by beta-glycosidic bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395302", "l": "Formation of hydroxylysino-5-ketonorleucine cross-links (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196964", "l": "RFK:Mg2+ phosphorylates RIB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050592", "l": "4-hydroxyphenylacetaldehyde oxime monooxygenase activity", "d": ["Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H+ + NADPH + O2 = (S)-4-hydroxymandelonitrile + 2 H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205286", "l": "GRB2:SOS interacts with p-KIT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420580", "l": "Nectin-1:PVRL3 trans heterodimer formation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938773", "l": "RNF144A polyubiquitinates PRKDC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856189", "l": "TNFSF8 binds TNFRSF8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9701147", "l": "TRPV1 binds TRPV1 blockers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022379", "l": "ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9707523", "l": "Hemes bind to BACH1:MAFK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482667", "l": "1-acyl LPE is acylated to PE by LPEAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76219", "l": "GDP(in) = GDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8856945", "l": "PP2A methylation by LCMT1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74544", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => (E,E,E)-alpha-springene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391151", "l": "p-4Y-SIRPA:CD47:SKAP2 binds FYB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8853898", "l": "VENTX binds the CSF1R (M-CSF-R) gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-375405", "l": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102142", "l": "[dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [dermatan]-alpha-L-iduronate = adenosine 3',5'-bismonophosphate + [dermatan-sulfate]-2-O-sulfo-alpha-L-iduronate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9731057", "l": "SARS-CoV-1 3a binds to caspase-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9676160", "l": "AAMP binds NOD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167481", "l": "Abortive termination of HIV-1 elongation after arrest (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114284", "l": "Release of Cytochrome c from mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72742", "l": "chloride(in) + 2 hydrogencarbonate(out) + Na(+)(out) <=> chloride(out) + 2 hydrogencarbonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10995", "l": "glycolate + NADP(+) <=> glyoxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63796", "l": "C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44718", "l": "AH2 + all-trans-4,4'-diapolycopen-4-oate + H(+) => A + all-trans-4,4'-diapolycopen-4-al + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708866", "l": "pro-F2R binds vorapaxar (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158722", "l": "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46748", "l": "carboxyphosphate + NH4(+) = carbamate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676229", "l": "WIPIs bind PI3P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5628905", "l": "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14878", "l": "ATP + L-glutamate => ADP + L-glutamyl 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676162", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5621888", "l": "Defective HK1 does not phosphorylate Glc to form G6P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-202248", "l": "Phosphorylation of PLC-gamma1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685319", "l": "CX3 complex formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351207", "l": "Spermine  => N-acetylated spermine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45502", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin beta-subunit] => phycocyanobilin-L-cysteinyl(84)-[allophycocyanin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65657", "l": "A + cholest-1,4-dien-3-one + H2O => 25-hydroxycholest-1,4-dien-3-one + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482961", "l": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69546", "l": "6-O-adenylylstreptidine + diphosphate => ATP + streptidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1640164", "l": "ENPP7 hydrolyzes sphingomyelin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45369", "l": "H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + (9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13624", "l": "4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose <=> 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71994", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate <=> (-)-astellatene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8982637", "l": "Opsins binds G alpha-t (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102294", "l": "cholesterol dehydrogenase activity", "d": ["Catalysis of the reaction: cholesterol + NAD = cholest-5-en-3-one + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74986", "l": "Elongation of pre-rRNA transcript (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189062", "l": "lactose + H2O => D-glucose + D-galactose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-68611", "l": "Formation of ORC(1-5) complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46207", "l": "androst-5-en-3beta,17beta-diol + O2 + reduced [NADPH--hemoprotein reductase] <=> androst-5-en-3beta,7alpha,17beta-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905030", "l": "voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "d": ["Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42212", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O = a 2-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.2.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76807", "l": "(S)-isoleucinol + H2O + NAD(+) = (3S)-1-hydroxy-3-methylpentan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65484", "l": "hexan-1-ol + hexanoyl-CoA = CoA + hexyl hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38027", "l": "(E)-caffeate + hydrocaffeoyl-CoA = (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate", "d": [], "t": []}, {"i": "EC:2.8.3.23", "l": "\"caffeate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879674", "l": "CD97 binds CD55 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22788", "l": "dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:2.1.1.3", "l": "\"thetin--homocysteine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38205", "l": "19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015210", "l": "uracil transmembrane transporter activity", "d": ["Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45368", "l": "H2O + N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + (9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211959", "l": "CYP3A43 6b-hydroxylates TEST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50483", "l": "acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45242", "l": "a (2E,4E)-(5,6-saturated)-dienoyl-CoA => a (3E,5Z)-dienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26511", "l": "H2O + L-prolinamide => L-proline + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43863", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23548", "l": "guanosine(966) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.171", "l": "\"16S rRNA (guanine(966)-N(2))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12273", "l": "H(+) + L-dopa => CO2 + dopamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47056", "l": "4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8869568", "l": "NPM1 binds TFAP2A homodimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62757", "l": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39057", "l": "22-oxodocosanoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 22-hydroxydocosanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229203", "l": "PRMT6 methylates histone H2A arginine-30 (H2AR29) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139919", "l": "Translocation of BIM to mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008421", "l": "long-chain fatty-acyl-glutamate deacylase activity", "d": ["Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823939", "l": "IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047013", "l": "cholate 12-alpha dehydrogenase activity", "d": ["Catalysis of the reaction: cholate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047093", "l": "4-hydroxyquinoline 3-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + quinolin-4-ol = H2O + NAD+ + quinoline-3,4-diol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39475", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA = (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74458", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) <=> 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49048", "l": "25-hydroxyvitamin D2 + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,25-dihydroxyvitamin D2 + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694428", "l": "LMAN family proteins bind glycosylated cargo (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21126", "l": "5-methylcytidine(72) in tRNA(Thr) + H(+) + S-adenosyl-L-homocysteine => cytidine(72) in tRNA(Thr) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12147", "l": "cyanidin 3-O-rutinoside + UDP-alpha-D-glucose <=> cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993898", "l": "VRK1/VRK2 phosphorylate BANF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2168038", "l": "Collagen type XV restin release (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625421", "l": "The anterograde IFT train dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444691", "l": "Prokineticin receptors bind prokineticin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58696", "l": "NADPH + O2 + rifampicin = H(+) + H2O + NADP(+) + rifampicin para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2731074", "l": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-622310", "l": "Activated NOD1 oligomerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46108", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 = (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15555", "l": "1D-myo-inositol 4-phosphate + phosphate => 1D-myo-inositol 1,4-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40248", "l": "H2O + rhodomycin D => 10-carboxy-13-deoxycarminomycin + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19843", "l": "CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14321", "l": "morphine + NADP(+) = H(+) + morphinone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-140748", "l": "tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851908", "l": "Activated MET binds GAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14766", "l": "coelenterazine h + O2 => CO2 + excited coelenteramide h monoanion + H(+) + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43212", "l": "adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.230", "l": "\"23S rRNA (adenosine(1067)-2'-O)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604360", "l": "Initial activation of proMMP2 by MMP14 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-180687", "l": "Conversion of Ran-GDP to Ran-GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70600", "l": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68903", "l": "4-methoxybenzoate + ATP + H(+) + NADPH <=> 4-methoxybenzaldehyde + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17473", "l": "GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)", "d": [], "t": []}, {"i": "EC:3.5.4.16", "l": "\"GTP cyclohydrolase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76054", "l": "(S)-scoulerine + S-adenosyl-L-methionine <=> (S)-cis-N-methylscoulerine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2160851", "l": "HAS1,2,3 mediate the polymerization of HA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9732738", "l": "JAK1-mediated phosphorylation of RAF1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12184", "l": "(S,S)-butane-2,3-diol + NAD(+) = (S)-acetoin + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.76", "l": "\"(S,S)-butanediol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419166", "l": "GEFs activate RhoA,B,C (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32826", "l": "phosphate(in) <=> phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9605682", "l": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102328", "l": "3-oxoacid decarboxylase activity", "d": ["Catalysis of the reaction: H+ + a 3-oxoacid = carbon dioxide + a methylketone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174401", "l": "AHCY:NAD+ tetramer hydrolyses AdoHcy (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046972", "l": "histone H4K16 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60483", "l": "2 UTP <=> c-di-UMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613768", "l": "SOX10, POU3F1 and POU3F2 bind EGR2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59018", "l": "CO2 + cycloeucalenone + NADH => 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1299359", "l": "Activation of TALK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52558", "l": "3-dehydro-4-O-phospho-D-erythronate + ADP + H(+) => 3-dehydro-D-erythronate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32573", "l": "2-methylisoborneol + diphosphate => (E)-2-methylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050634", "l": "phloroisovalerophenone synthase activity", "d": ["Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68595", "l": "ORC2 binds ORC3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938201", "l": "MYL9 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28686", "l": "L-aspartate + ubiquinone-8 <=> iminosuccinate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48191", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48723", "l": "aurachin B + H2O + NAD(+) <=> 4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36201", "l": "1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33035", "l": "2-oxospirilloxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = 2,2'-dioxospirilloxanthin + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70051", "l": "2-oxoadipate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8981637", "l": "RHOA GAPs stimulate RHOA GTPase activity (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9796059", "l": "AcK-NFE2L2 binds the BCL2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29019", "l": "D-galactose(in) + H(+)(in) = D-galactose(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204485", "l": "Basigin binds CyPA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592238", "l": "Expression of ALAS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35728", "l": "dodecanoyl-CoA + sn-glycerol 3-phosphate => 1-dodecanoyl-sn-glycerol 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19348", "l": "(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate <=> (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10443", "l": "D-glucono-1,5-lactone + H2O <=> D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9021068", "l": "PalmS-ESRs bind CAVs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49836", "l": "(5E)-tetradecenoyl-CoA + (R)-carnitine = (5E)-tetradecenoyl-(R)-carnitine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-418845", "l": "Activation of caspase-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019181", "l": "halohydrin hydrogen-halide-lyase activity", "d": ["Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696091", "l": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77202", "l": "3'-phosphoadenylyl sulfate + 3beta-hydroxy-5-cholenate <=> 3beta-sulfo-5-cholenate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672027", "l": "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44539", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-O-acyl-N-(acetyl)-sphing-4-enine + a 2-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64739", "l": "4-hydroxynonanal + NADP(+) <=> (E)-4-hydroxynon-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097098", "l": "DNA/RNA hybrid annealing activity", "d": ["An activity that facilitates the base-pairing of single-stranded RNA to double-stranded DNA resulting in the formation of R-loops."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381518", "l": "PAAP-A proteolyzes IGF:IGFBP4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803063", "l": "RNASEs bind bacterial LPS, PGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9614423", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45040", "l": "2 Fe(III)-[cytochrome c] + hydroxylamine = 2 Fe(II)-[cytochrome c] + 2 H(+) + nitroxyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12032", "l": "a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.77", "l": "\"acyloxyacyl hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50496", "l": "acetyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54928", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH = (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986995", "l": "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003980", "l": "UDP-glucose:glycoprotein glucosyltransferase activity", "d": ["Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17684", "l": "3-hydroxy-2-methylpropanoate + NAD(+) <=> 2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18298", "l": "a phtalamide + H2O => a primary amine + phthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814086", "l": "ARFRP1 recruits ARL1 to the TGN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59452", "l": "a long-chain primary fatty alcohol + NADP(+) = a long-chain fatty aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47275", "l": "monoanhydrobacterioruberin <=> bisanhydrobacterioruberin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004679", "l": "AMP-activated protein kinase activity", "d": ["Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31441", "l": "alpha-longipinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-964811", "l": "C5AR2 binds anaphylatoxins and thier desArginated derivatives (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371435", "l": "Constitutive phosphorylation by GSK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33122", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-sativene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047347", "l": "aldose-1-phosphate nucleotidyltransferase activity", "d": ["Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112379", "l": "Recruitment of elongation factors to form elongation complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097602", "l": "cullin family protein binding", "d": ["Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-879459", "l": "F-actin capping protein is a heterodimer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48578", "l": "3-chloro-cis,cis-muconate + 2 H(+) => 4-chlorocatechol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5627737", "l": "SLC26A3 does not exchange Cl- for HCO3- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53615", "l": "CTP + D-ribulose 5-phosphate + H(+) <=> CDP-D-ribulose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73891", "l": "ATP + L-glutamate + spermidine = ADP + gamma-L-glutamylspermidine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74612", "l": "UDP-alpha-D-galactose(in) + UDP-N-acetyl-alpha-D-glucosamine(out) => UDP-alpha-D-galactose(out) + UDP-N-acetyl-alpha-D-glucosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4608855", "l": "PRICKLE1 is degraded by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27671", "l": "1D-myo-inositol 1-phosphate + H2O => myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73248", "l": "ladanein + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102042", "l": "dehydroquinate synthase activity", "d": ["Catalysis of the reaction: 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonic acid + H2O + NAD = 3-dehydroquinate + ammonium + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55153", "l": "H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein] => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392064", "l": "G alpha (z) inhibits adenylate cyclase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42605", "l": "2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O => (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45298", "l": "a sphingoid base + H(+) + phosphocholine => a sphingosylphosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008786", "l": "D-allose 6-phosphate isomerase activity", "d": ["Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39379", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH = (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944397", "l": "p-T69,T71-ATF2 binds PTEN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668419", "l": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446077", "l": "BP230 interacts with keretin K5/K14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77077", "l": "Capping complex formation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63108", "l": "16-hydroxy-ilicicolin A epoxide = ascofuranol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44953", "l": "(2E)-octenoyl-CoA + H(+) + NADPH => NADP(+) + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64650", "l": "(E)-feruloyl-CoA + H(+) + NADPH => (E)-coniferaldehyde + CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9645520", "l": "ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166792", "l": "Conversion of C2 into C2a and C2b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013978", "l": "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5607741", "l": "p52:RELB translocates from cytosol to nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14208", "l": "carnosine + S-adenosyl-L-methionine <=> anserine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51246", "l": "(13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937864", "l": "RUNX2 binds tyrosine phosphorylated YAP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4419978", "l": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18311", "l": "a carboxylate + a D-alpha-amino acid => an N-acyl-D-amino acid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655252", "l": "Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63708", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl derivative + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl derivative + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74256", "l": "H2O + L-homoseryl-tRNA(Ser) => H(+) + L-homoserine + tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380240", "l": "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2872497", "l": "SLC17A3-2 transports cytosolic urate to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047334", "l": "diphosphate-fructose-6-phosphate 1-phosphotransferase activity", "d": ["Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102754", "l": "chlorophyllide-b:phytyl-diphosphate phytyltransferase activity", "d": ["Catalysis of the reaction: H+ + chlorophyllide b + (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate = chlorophyll b + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44271", "l": "3 H(+) + hexadecanoyl-CoA + 3 malonyl-CoA <=> 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953339", "l": "DNPH1 hydrolyses dGMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.55", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2272753", "l": "Interaction of DAP12 and KIR2DS4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028724", "l": "AMOT proteins bind YAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21405", "l": "chloride + O2 => chlorite", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27862", "l": "3'-GMP + H2O = guanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54377", "l": "(+)-copalyl diphosphate + H2O => diphosphate + nezukol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77228", "l": "AH2 + gentamicin X2 + 2 S-adenosyl-L-methionine => 5'-deoxyadenosine + A + geneticin + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33721", "l": "a 1,2-diacyl-sn-glycerol + N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + N-hexacosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61064", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.22", "l": "\"stromelysin 2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444433", "l": "Cho transports from the extracellular space to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5668481", "l": "Protesomal degradation of K48polyUb-TRAF3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22057", "l": "hexadecan-1-ol + NAD(+) => H(+) + hexadecanal + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445704", "l": "Calcium Binds Caldesmon (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69213", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ATP + L-glutamate => (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5357860", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39728", "l": "a sphingomyelin(in) => a sphingomyelin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38030", "l": "(E)-caffeate + hydrocaffeoyl-CoA <=> (E)-caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351341", "l": "Exocytosis of Proactivator polypeptide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26373", "l": "[thioredoxin]-disulfide + prostamide F2alpha = [thioredoxin]-dithiol + prostamide H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16556", "l": "aldehydo-D-ribose 5-phosphate + L-lysyl-[protein] <=> H2O + N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-156699", "l": "Inactivation of Wee1 kinase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16250", "l": "alpha-D-glucose 6-phosphate => beta-D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866542", "l": "VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5637686", "l": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58146", "l": "AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met) => acetate + ATP + cytidine(34) in elongator tRNA(Met)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33879", "l": "2-deoxy-scyllo-inosamine + NADP(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19908", "l": "NAD(+) + spermidine <=> dehydrospermidine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52032", "l": "H2O + L-isoleucine-(+)-7-isojasmonate = (+)-7-isojasmonate + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1963582", "l": "Trans-autophosphorylation of ERBB2 heterodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25633", "l": "laricitrin + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + syringetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6808496", "l": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784204", "l": "JAKs bind OSMR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73417", "l": "H(+) + methyl isocyanate + viridicatin => (-)-cyclopenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9679029", "l": "C-ter TLR7 dimer binds HCQ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625883", "l": "PKN1 in complex with AR positively regulates expression of KLK2 and KLK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67302", "l": "3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one => (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32972", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + 2 H2O => 2 a carboxylate + 2 H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62397", "l": "(1S,2S)-pseudoephedrine + NAD(+) => (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22585", "l": "2 H(+) + heme b => Fe(2+) + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62518", "l": "a ganglioside GA2 + H(+) + UDP => a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71156", "l": "(E)-caffeoylpyruvate + H2O => (E)-caffeate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997311", "l": "Dephosphorylation of TYK2 by PTP1B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20080", "l": "guanosine(18) in tRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851137", "l": "STAT3-dependent DNMT1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9795207", "l": "SLC22A1 transports Cipro into hepatic cell (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37259", "l": "(2S)-2-aminobutanoate + H2O + NAD(+) = 2-oxobutanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77932", "l": "N-(4-oxobutylpyrrolinium) ion => 1-formylpyrrolizidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1358795", "l": "Deubiquitination of RNF41 by P-USP8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14180", "l": "(R)-amygdalin + H2O <=> (R)-prunasin + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9640167", "l": "RRAGA,B exchanges GDP for GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9854405", "l": "Frataxin transfers Fe2+ to ACO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38815", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50088", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67875", "l": "3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose <=> 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635845", "l": "GLI proteins bind CDC73 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72944", "l": "2 Na(+)(out) + pyruvate(out) => 2 Na(+)(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981497", "l": "ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35260", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O => 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030108", "l": "HLA-A specific activating MHC class I receptor activity", "d": ["Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954082", "l": "E2F6 binds the PRC1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12439", "l": "(E)-caffeoyl-CoA + putrescine <=> CoA + H(+) + N-caffeoylputrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20723", "l": "H2O + isopenicillin N + phenylacetyl-CoA <=> CoA + H(+) + L-2-aminoadipate + penicillin G", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53317", "l": "GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate => alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9854368", "l": "ROS,RNS oxidize ACO2:4Fe-4S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21690", "l": "an oxidized polyvinyl alcohol + n H2O2 => a polyvinyl alcohol + n O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176702", "l": "Disassociation of Processive Complex and Completed Telomere End (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6782211", "l": "DNA polymerases delta, epsilon or kappa bind the TC-NER site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805426", "l": "CARD8 binds CASP9(1-416) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008816", "l": "citryl-CoA lyase activity", "d": ["Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.583239357332701", "identifiers": [{"i": "GO:0005351", "l": "carbohydrate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in)."], "t": []}, {"i": "TCDB:2.A.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42555", "l": "uridine(31) in tRNA <=> pseudouridine(31) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5662620", "l": "MT3 binds cadmium (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57047", "l": "D-apionate + NAD(+) <=> 3-oxoisoapionate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53453", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16196", "l": "an (R)-2-haloacid + H2O <=> a (2R)-2-hydroxycarboxylate + a halide anion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103101", "l": "UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 7-methylthioheptylhydroximate = H+ + 6-methylthiohexyldesulfoglucosinolate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76718", "l": "(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione <=> (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47882", "l": "H(+) + octanoate + octanoylglycerol => dioctanoylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610723", "l": "GLI proteins bind SUFU (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17512", "l": "H2O + thiamine <=> 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047530", "l": "2,4-diaminopentanoate dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73174", "l": "adenosine 3',5'-bisphosphate(out) + NAD(+)(in) <=> adenosine 3',5'-bisphosphate(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8862137", "l": "HSD17B2 oxidises estradiol (E2) to estrone (E1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64774", "l": "2-aminoprop-2-enoate + 2-methyl-3-sulfanylbutan-1-ol => S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23551", "l": "guanosine(966) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12222", "l": "4-methyl-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-leucine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030233", "l": "deoxynucleotide transmembrane transporter activity", "d": ["Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006844", "l": "IL21:IL21R:JAK1 binds IL2RG:JAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57271", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GMP <=> GMP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651828", "l": "PARG dePARylates PARP1,PARP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10000", "l": "H2O + pentanamide = NH4(+) + pentanoate", "d": [], "t": []}, {"i": "EC:3.5.1.50", "l": "\"pentanamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-156808", "l": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43528", "l": "L-serine + NAD(+) = 2-aminomalonate semialdehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033803", "l": "kaempferol 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + H+ + kaempferide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71658", "l": "an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O <=> a thymidine in DNA + ADP-D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810724", "l": "PI3 binds the bacterial surface (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141038", "l": "phosphatidylinositol 3-kinase activator activity", "d": ["Binds to and increases the activity of a phosphatidylinositol 3-kinase (PI3K)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0062156", "l": "mitochondrial ATP-gated potassium channel activity", "d": ["Enables the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63776", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198813", "l": "GSTO dimers reduce DeHA to AscH- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028670", "l": "Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17792", "l": "(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine <=> (S)-reticuline + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63160", "l": "H2O + N-(15Z-tetracosenoyl)-taurine = (15Z)-tetracosenoate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46799", "l": "an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-187552", "l": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052798", "l": "beta-galactoside alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54669", "l": "pre-alpha-onocerin => alpha-onocerin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1980128", "l": "NOTCH1 associates with negative regulators NUMB and ITCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75314", "l": "D-serine(in) + L-alanine(out) + Na(+)(out) <=> D-serine(out) + L-alanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.114", "l": "\"3-dehydro-bile acid Delta(4,6)-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004712", "l": "protein serine/threonine/tyrosine kinase activity", "d": ["Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182243", "l": "Formation of MHC I:Nef Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-879311", "l": "mycothiol S-conjugate is cleaved into mercapturic acid and GlcN-Ins (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8862771", "l": "PLA2G2A binds bacterial phospholipids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048027", "l": "mRNA 5'-UTR binding", "d": ["Binding to an mRNA molecule at its 5' untranslated region."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912382", "l": "Mature NOTCH heterodimer traffics to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45213", "l": "acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+) => CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-202237", "l": "Hydrolysis of PIP3 to PI(3,4)P2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44829", "l": "(R)-carnitine + decanoyl-CoA => CoA + O-decanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014766", "l": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2130279", "l": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430076", "l": "GP1b-IX-V binds 14-3-3-zeta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811433", "l": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161660", "l": "PGH2 is isomerised to PGE2 by PTGES (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035612", "l": "AP-2 adaptor complex binding", "d": ["Binding to an AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203946", "l": "PDK isozymes phosphorylate PDHC subunit E1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1295634", "l": "SPRY2 is serine phosphorylated in response to MAPK activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018025", "l": "calmodulin-lysine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607757", "l": "K63polyUb-TRAF6 ubiquitinates TAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76837", "l": "acetaldehyde + H(+) + NADH + NH4(+) => ethylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9696268", "l": "RND3 binds effectors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-879528", "l": "SLCO2A1 transports PGT substrates from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22784", "l": "(2R)-O-phospho-3-sulfolactate = H(+) + phosphoenolpyruvate + sulfite", "d": [], "t": []}, {"i": "EC:4.4.1.19", "l": "\"phosphosulfolactate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948623", "l": "miR-20 microRNAs bind CNOT6L mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70955", "l": "H(+)(in) + L-glutamate(in) = H(+)(out) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47016", "l": "[DsrC protein]-S-sulfanyl-L-cysteine/L-cysteine + 2 A + 3 H2O = [DsrC protein]-dithiol + 2 AH2 + 2 H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627089", "l": "CASP9 is phosphorylated at T412 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47250", "l": "2 Fe(II)-[cytochrome c] + 3 H(+) + L-ascorbate => 2 Fe(III)-[cytochrome c] + L-gulono-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390930", "l": "5-HT2 receptor can bind serotonin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047472", "l": "3-carboxy-cis,cis-muconate cycloisomerase activity", "d": ["Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78567", "l": "acetyl-CoA + docosanoyl-CoA = 3-oxotetracosanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162192", "l": "COQ2 ligates all-E-10PrP2 to PHB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47868", "l": "di-(9Z)-octadecenoylglycerol + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844111", "l": "EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0048039", "l": "ubiquinone binding", "d": ["Binding to ubiquinone, a quinone derivative with a tail of isoprene units."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19368", "l": "ATP + D-ribulose 5-phosphate <=> ADP + D-ribulose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34280", "l": "di-trans,poly-cis-dolichol + NADP(+) => di-trans,cis-polyprenol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44193", "l": "2-methylhexadecanoate + ATP + CoA => 2-methylhexadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.1.1.-", "l": "\"Hydron translocation or charge separation linked to oxidoreductase reactions\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51155", "l": "2 a thiol + L-cysteinyl-[sulfatase] + O2 <=> 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710101", "l": "CASP4, CASP5 cleave GSDMD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45258", "l": "hexadecanoate(in) => hexadecanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222526", "l": "AhpC reduces peroxidated lipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44251", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76819", "l": "D-aspartate + H2O + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61954", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56040", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) = beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9696275", "l": "RND2 binds GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018422", "l": "GDP-mannose:serine-protein mannose-1-phosphotransferase activity", "d": ["Catalysis of the transfer of mannose-1-phosphate to a serine residue in a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6804253", "l": "MDM2 ubiquitinates JMY (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29450", "l": "glycolate(in) <=> glycolate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46906", "l": "a 1,2-diacyl-sn-glycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate) => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A hexaacyl 1-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9603989", "l": "B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0004854", "l": "xanthine dehydrogenase activity", "d": ["Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77729", "l": "1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610767", "l": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23686", "l": "allocryptopine + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (S)-cis-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72617", "l": "H(+)(in) + L-alanyl-L-valine(in) => H(+)(out) + L-alanyl-L-valine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730843", "l": "Phosphorylation of LAT by p-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20754", "l": "AH2 + 2 aquacob(III)alamin => A + 2 cob(II)alamin + 2 H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.81837140711167", "identifiers": [{"i": "GO:0016725", "l": "oxidoreductase activity, acting on CH or CH2 groups", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor."], "t": []}, {"i": "EC:1.17.-.-", "l": "\"Acting on CH or CH2 groups\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69348", "l": "S-1-propenyl-L-cysteine sulfoxide = (E)-prop-1-en-1-SO-peroxol + 2-aminoprop-2-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10185", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O => 3-oxoadipate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2530445", "l": "CD59 inhibits MAC formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75349", "l": "thiocyanate(out) => thiocyanate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140216", "l": "Translocation of PMAIP1 (NOXA) to mitochondria (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27458", "l": "3-iodo-L-tyrosine + iodide + NADP(+) => 3,5-diiodo-L-tyrosine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756948", "l": "p-2S-SMAD2,3:SMAD4, p-2S-SMAD2,3:TRIM33, CTNNB1, EOMES, and TBPL2 bind FOXH1:SMAD3:GSC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15975", "l": "adenosine 3',5'-bisphosphate + estrone 3-sulfate + H(+) => 3'-phosphoadenylyl sulfate + estrone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446372", "l": "Association of  PARVA with TESK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64085", "l": "2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxylate + H(+) => 2,3,6,8,9-pentahydroxy-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracen-1-one + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14203", "l": "D-xylulose => D-lyxose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-708349", "l": "Activated NOD2 oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-213406", "l": "Disassociation of PLC-gamma1 from LAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209289", "l": "TAB2 binds to ubiquitinated IAP2:BEN:UEV1A E3 ligase complex and activates TAK1 kinase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21108", "l": "(S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508292", "l": "SYK binds IL2RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2129357", "l": "Fibrillin C-terminal processing (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389759", "l": "Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62942", "l": "acetate + cytosine + H(+) => H2O + N(4)-acetylcytosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72982", "l": "didemethylasterriquinone D + dimethylallyl diphosphate <=> asterriquinone C1 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757951", "l": "CASP8 cleaves N4BP1 at D424, D490 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71589", "l": "(S)-malate(out) + 2-oxoglutarate(in) => (S)-malate(in) + 2-oxoglutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50524", "l": "acetyl-CoA + N-terminal L-methionyl-L-isoleucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191303", "l": "FDPS dimer transfers IPPP to GPP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48010", "l": "2,5-dihydroxybenzoyl-CoA + H2O + NAD(+) => 2-hydroxybenzoyl-CoA + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40404", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3371590", "l": "HSP70 binds to HSP40:nascent protein (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983378", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-264418", "l": "Translocation of COP1 from the nucleus to the cytoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70872", "l": "L-glutamine(in) + L-valine(out) + Na(+)(out) => L-glutamine(out) + L-valine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4568914", "l": "SUMOylation of BLM with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193650", "l": "p75NTR binds to NADE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54131", "l": "3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1467466", "l": "ABCA4 mediates atRAL transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16482", "l": "3 S-adenosyl-L-methionine => 3 H(+) + nicotianamine + 3 S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70772", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine => 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956676", "l": "YAP1 binds TP73 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051500", "l": "D-tyrosyl-tRNA(Tyr) deacylase activity", "d": ["Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604360", "l": "Initial activation of proMMP2 by MMP14 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35196", "l": "L-quinate(in) => L-quinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44935", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA <=> (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982025", "l": "G alpha (q) in G (q):RGS complex is inactivated (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166214", "l": "FA anion flip-flops to the opposite surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70997", "l": "SUCLG1/A2 cleaves succinyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-873917", "l": "Translocation of STAT1 dimer to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-141351", "l": "PAOX:FAD oxidises NASPN to SPM (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109858", "l": "MAP2K2 binds MAPK1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63514", "l": "biphenyl-2,2',3-triol + H2O + NAD(+) => biphenyl-2,2'-diol + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34089", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester => a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23129", "l": "4-hydroxybutanoate + ATP + CoA => 4-hydroxybutanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34565", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H(+) + NADPH => CDP-alpha-D-abequose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482816", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[6] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17495", "l": "AH2 + dihydroxyacetone => A + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13560", "l": "ATP + gamma-L-glutamyl-L-cysteine + glycine <=> ADP + glutathione + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977333", "l": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15987", "l": "CO2 + NADH => formate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8983379", "l": "p-Y-STAT3:p-STAT5 translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014074", "l": "TXLNA (IL14) binds syntaxin4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45526", "l": "(2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] => phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45813", "l": "a very-long-chain (3R)-3-hydroxyacyl-CoA => a very-long-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13433", "l": "2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76199", "l": "oxalate(in) = oxalate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11467", "l": "2 glutathione + L,L-homocystine <=> glutathione disulfide + 2 L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15061", "l": "2 a Fe(II)-siderophore + H(+) + NAD(+) = 2 a Fe(III)-siderophore + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981353", "l": "RASA1 stimulates RAS GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-452036", "l": "arginine + H2O => ornithine + urea [ARG2] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174119", "l": "Free APC/C phosphorylated by Plk1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-197958", "l": "FPGS-2 transforms THF to THFPG (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13170", "l": "maleate => fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35167", "l": "minocycline(in) = minocycline(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797554", "l": "ABP1 binds SHANK proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70311", "l": "beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174122", "l": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46556", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + lathosterol + O2 = 7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9005980", "l": "IL21 binds IL21R:JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14260", "l": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63293", "l": "N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine => H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693978", "l": "Small molecule inhibitor binds RIPK1, RIPK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1605736", "l": "GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54979", "l": "(3S)-hydroxytetradecanoyl-CoA + H2O <=> (3S)-hydroxytetradecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.3.11", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24681", "l": "5,6,7,8-tetrahydromethanopterin + formaldehyde <=> 5,10-methylenetetrahydromethanopterin + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5631885", "l": "PRDX1 overoxidizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21299", "l": "D-galactose + NAD(+) <=> D-galactono-1,4-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37639", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31635", "l": "beta-D-Delta(4)-GlcA-(1->4)-beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc + H2O = 5-dehydro-4-deoxy-D-glucuronate + beta-D-Glc-(1->4)-alpha-L-Rha-(1->3)-D-Glc", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34450", "l": "dTDP-6-deoxy-beta-L-talose + NAD(+) <=> dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614544", "l": "Sulfite is oxidized to sulfate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75071", "l": "chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in) = chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20086", "l": "a flavonol 3-O-beta-D-glucoside + malonyl-CoA => a flavonol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11353", "l": "acetate + ATP => acetyl phosphate + ADP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43730", "l": "H(+) + H2O + juvenile hormone III + oxidized [NADPH--hemoprotein reductase] => methyl (2E,6E)-farnesoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6804276", "l": "ATM phosphorylates TTC5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47889", "l": "GDP-beta-L-fucose + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine => GDP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-alpha-L-fucosyl-(1->4)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25371", "l": "(2S)-2-amino-4-deoxychorismate + FMN = 3-(1-carboxyvinyloxy)anthranilate + FMNH2", "d": [], "t": []}, {"i": "EC:1.3.8.16", "l": "\"2-amino-4-deoxychorismate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191303", "l": "FDPS dimer transfers IPPP to GPP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11979", "l": "anhydrotetracycline + H(+) + NADPH + O2 <=> 5a,11a-dehydrotetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41569", "l": "aclacinomycin T + dTDP-2-deoxy-beta-L-fucose => aclacinomycin S + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55736", "l": "alpha-D-galacturonosyl-[(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n) + UDP-beta-L-rhamnose = [(1->2)-alpha-L-rhamnosyl-(1->4)-alpha-D-galacturonosyl](n+1) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.351", "l": "\"rhamnogalacturonan I rhamnosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78513", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine => a 5'-end (5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45686", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(out) => N-dodecanoyl-sphing-4-enine-1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0033250", "l": "penicillinase activity", "d": ["Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8847883", "l": "CYTH proteins stimulate ARF1 GTPase activity (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23269", "l": "guanidinoacetate + H2O => glycine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-171122", "l": "LDL + LDLR => LDL:LDLR complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9647994", "l": "RAS proteins are depalmitoylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1592387", "l": "Fibulin binds elastic fibres (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005004", "l": "GPI-linked ephrin receptor activity", "d": ["Combining with a GPI-anchored ephrin to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78278", "l": "(2E,6E,10E)-geranylgeranyl diphosphate <=> delta-araneosene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018484", "l": "4-hydroxybenzaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4647594", "l": "SAHF formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63256", "l": "1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19543", "l": "H(+) + L-glutamyl 5-phosphate + NADPH => L-glutamate 5-semialdehyde + NADP(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11659", "l": "ATP + holo-[peptidyl-carrier protein] + L-proline <=> AMP + diphosphate + L-prolyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853801", "l": "PSPN binds RET:GFRA4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8855490", "l": "Lactoperoxidase (LPO) produces OSCN- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636304", "l": "Mce3E binds MAPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018808", "l": "RAC3 binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941915", "l": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62795", "l": "3 H(+) + NADPH + O2 + 2 rubrofusarin B <=> 2 H2O + NADP(+) + nigerone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41036", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + hexadecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-hexadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2396083", "l": "Laminins bind galactosyl sulfatide and related sulfated glycolipids (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-964884", "l": "Dephosphorylation of EPSP yields chorismate (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102829", "l": "ajugose synthase activity", "d": ["Catalysis of the reaction: 2 verbascose = ajugose + stachyose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20872", "l": "(20S)-ginsenoside Rd + UDP-alpha-D-glucose = (20S)-ginsenoside Rb1 + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.314", "l": "\"ginsenoside Rd glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42597", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => prostaglandin G2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51570", "l": "(25S)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211923", "l": "CYP26C1 4-hydroxylates 9cRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33367", "l": "D-glucose(out) + N(pros)-phospho-L-histidyl-[protein] = D-glucose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.199", "l": "\"protein-N(pi)-phosphohistidine--D-glucose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.1", "l": "\"ethanolaminephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19032", "l": "3 H(+) + H2O + urea-1-carboxylate <=> 2 CO2 + 2 NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5228523", "l": "RANBP2 SUMOylates MDM2 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189406", "l": "4 PBGs bind to form HMB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73844", "l": "a 27-hydroxysterol + UDP-alpha-D-glucose => a sterol 27-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9754974", "l": "ADK phosphorylates RBV (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981621", "l": "C3 convertases spontaneously dissociate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787632", "l": "GMDS dehydrates GDP-Man to GDP-DHDMan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48891", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione <=> (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9818937", "l": "MEN1 binds MLL1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.8", "l": "\"endo-1,4-beta-xylanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58749", "l": "desmethylnectriapyrone + S-adenosyl-L-methionine => H(+) + nectriapyrone + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9632910", "l": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42748", "l": "cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.176", "l": "\"16S rRNA (cytosine(967)-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25077", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.21", "l": "\"DNA-3-methyladenine glycosylase II\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17100", "l": "3-phenylpyruvate <=> enol-phenylpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352119", "l": "SLC38A1 (ATA1)-mediated uptake of neutral amino acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008986", "l": "pyruvate, water dikinase activity", "d": ["Catalysis of the reaction: ATP + H2O + pyruvate = AMP + 3 H+ + phosphate + phosphoenolpyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57582", "l": "S-methyl-1-thiol-D-ribulose 5-phosphate => S-methyl-5-thio-D-ribulose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54354", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CMP + H(+) => 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10371", "l": "2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0061133", "l": "endopeptidase activator activity", "d": ["Binds to and increases the activity of an endopeptidase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11627", "l": "2-(hydroxyimino)propanoate + acetone <=> acetone oxime + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5578966", "l": "TNRC6A:AGO2:miRNA is transported into the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008859", "l": "exoribonuclease II activity", "d": ["Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42520", "l": "uridine(2605) in 23S rRNA = pseudouridine(2605) in 23S rRNA", "d": [], "t": []}, {"i": "EC:5.4.99.22", "l": "\"23S rRNA pseudouridine(2605) synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197235", "l": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44819", "l": "1,4-dihydroxy-2-naphthoate + all-trans-dodecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-12 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3134953", "l": "DHX36 or DHX9 binds MyD88 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17196", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852013", "l": "BTNL8 binds resting T cell surface (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445367", "l": "CaMKII binds activated NMDA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51844", "l": "(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909738", "l": "SHP1 and SHP2 bind the common beta chain (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665767", "l": "Activated FMNL3 binds G-actin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390649", "l": "CHRM1,3,5 bind acetylcholine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70995", "l": "L-cystine(out) + L-glutamate(in) = L-cystine(in) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75665", "l": "10,11-epoxy-12-hydroxy-(14Z)-eicosenoate => 12-hydroperoxy-(10E,14Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71853", "l": "glycocholate(in) => glycocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421222", "l": "inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0001648", "l": "proteinase-activated receptor activity", "d": ["A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76814", "l": "(S)-methioninol + H2O + NAD(+) <=> 1-hydroxy-4-(methythio)butan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11380", "l": "2-oxoglutarate + [2-(trimethylamino)ethyl]phosphonate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + CO2 + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.72", "l": "\"[2-(trimethylamino)ethyl]phosphonate dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647680", "l": "CASP1 cleaves GSDMD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0046975", "l": "histone H3K36 methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5688837", "l": "ATXN3 deubiquitinates polyUb-PARK2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809011", "l": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050383", "l": "uracil dehydrogenase activity", "d": ["Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65348", "l": "7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA = 3-oxochol-4,6-dien-24-oyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39243", "l": "(11Z)-3-oxoicosenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(11Z)-eicosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29954", "l": "H(+)(in) + uridine(in) <=> H(+)(out) + uridine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6804425", "l": "TP53 binds POU4F2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71723", "l": "H(+)(out) + L-alanyl-L-leucyl-L-alanine(out) = H(+)(in) + L-alanyl-L-leucyl-L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77179", "l": "(5'S,6'R)-C-glycyluridine + O2 = CO2 + H2O + uridine-5'-carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23256", "l": "adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine = adenosylcob(III)yrate + 4 ADP + 4 H(+) + 4 L-glutamate + 4 phosphate", "d": [], "t": []}, {"i": "EC:6.3.5.10", "l": "\"adenosylcobyric acid synthase (glutamine-hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46939", "l": "(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) <=> ATP + H(+) + L-2-aminoadipate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43197", "l": "adenosine(4) in tRNA(His) + S-adenosyl-L-methionine => 2'-O-methyladenosine(4) in tRNA(His) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9617927", "l": "FOXO4 binds ATXN3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668534", "l": "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22649", "l": "holo-[cytochrome c] => apo-[cytochrome c] + heme b", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9734535", "l": "SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74222", "l": "H2O + L-seryl-tRNA(Thr) <=> L-serine + tRNA(Thr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20653", "l": "23,24-dihydrocucurbitacin B + NAD(+) = cucurbitacin B + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24673", "l": "H2O + hypoxanthine + NAD(+) <=> H(+) + NADH + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655241", "l": "Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696323", "l": "CNRs bind CNR agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53799", "l": "deoxycholoyl-CoA + ursodeoxycholate <=> deoxycholate + ursodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783238", "l": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034658", "l": "isopropylmalate transmembrane transporter activity", "d": ["Enables the transfer of isopropylmalate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35788", "l": "paromamine + UDP-alpha-D-kanosamine => H(+) + kanamycin C + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55720", "l": "17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase] = 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43837", "l": "cholesterol + H(+) + NADPH + O2 => 26-hydroxycholesterol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18969", "l": "a long-chain fatty acid + H(+) + hnu = a long-chain alkane + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58008", "l": "(20S)-ginsenoside F1 + UDP-alpha-D-glucose = (20S)-ginsenoside Rg1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16696", "l": "alpha-pinene oxide <=> (Z)-2-methyl-5-isopropylhexa-2,5-dienal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214880", "l": "DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5251942", "l": "Hikeshi binds HSP70s:ATP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47938", "l": "4-hydroxybenzoate + 2 H(+) + NADPH => 4-hydroxybenzaldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-445797", "l": "MYLK (MLCK) Active Calmodulin Binding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640862", "l": "Tankyrase binds AXIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170044", "l": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694583", "l": "ABHD4 hydrolyses NAPE (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-140791", "l": "activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20156", "l": "ATP + L-arabinose <=> ADP + beta-L-arabinose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869633", "l": "NMRK1 phosphorylates NR to yield NMN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72475", "l": "cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35222", "l": "8-oxo-dADP + H2O <=> 8-oxo-dAMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39654", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O <=> 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54976", "l": "(3S)-hydroxytetradecanoyl-CoA + H2O = (3S)-hydroxytetradecanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49891", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + O2 <=> (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1,6-dicarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17794", "l": "H2O + L-alanyl-tRNA(Thr) => H(+) + L-alanine + tRNA(Thr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10931", "l": "ent-kaur-16-en-19-al + O2 + reduced [NADPH--hemoprotein reductase] <=> ent-kaur-16-en-19-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51842", "l": "2 Na(+)(in) + tauroallocholate(in) => 2 Na(+)(out) + tauroallocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35880", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754130", "l": "CDK4 inhibitors bind CDK4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1364044", "l": "PRLR:JAK2 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9796626", "l": "MIB2 ubiquitinates CFLAR  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174097", "l": "Association of Emi1 with Cdh1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2995330", "l": "COX10 transforms heme to heme O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69247", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate <=> 5-methylsulfinylpentyl nitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004085", "l": "butyryl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: butanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102928", "l": "beta-solanine rhamnosyltransferase activity", "d": ["Catalysis of the reaction: beta-solanine + UDP-L-rhamnose = solanine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914018", "l": "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004657", "l": "proline dehydrogenase activity", "d": ["Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39122", "l": "(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5665608", "l": "TCF:Beta-catenin binds SOX proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35521", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ethanolamine => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl) ethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102300", "l": "linoleate 9R-lipoxygenase activity", "d": ["Catalysis of the reaction: linoleate + O2 = 9(R)-HPODE."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624120", "l": "CEBPA binds CDK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9013023", "l": "RHOB GEFs activate RHOB (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68327", "l": "1D-myo-inositol 2,5-bisphosphate + H2O <=> 1D-myo-inositol 2-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193816", "l": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176264", "l": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112120", "l": "Oxidative demethylation of 3-meC damaged DNA by ALKBH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54826", "l": "alpha-D-glucosyl-(1->3)-D-mannopyranose + N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) => H2O + N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70034", "l": "6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-167415", "l": "G-protein alpha subunit is inactivated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11912", "l": "13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19126", "l": "glyoxylate + L-serine => 3-hydroxypyruvate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1678998", "l": "Endosomal TLRs pass through the Golgi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1980125", "l": "ITCH binds DTX (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9008587", "l": "IL37, IL37(?-218) binds IL18BP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034881", "l": "citrazinate hydrolase activity", "d": ["Catalysis of the reaction: citrazinate + H2O = cis-aconitamide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65661", "l": "A + calciol + H2O => AH2 + calcidiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38525", "l": "(9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+) => 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9825772", "l": "SIRT1 deacetylates HINT1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58936", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate + H(+) + NADH = all-trans-lycopaoctaene + 2 diphosphate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785213", "l": "LIPC dimer binds heparin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5140741", "l": "WNT5A binds FZD and ROR receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67816", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2468041", "l": "CDCA5 (Sororin) enables cohesion of sister chromosomal arms (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67735", "l": "uridylyl-uridylyl-ribonucleotide-RNA <=> a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102597", "l": "3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity", "d": ["Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 = oryzalexin E + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9704297", "l": "CHRM2 binds CHRM2 antagonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72314", "l": "glutathione(in) + taurocholate(out) <=> glutathione(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34465", "l": "cis-abienol + diphosphate => 8-hydroxycopalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45448", "l": "H2O + N-(dodecanoyl)-sphinganine = dodecanoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47963", "l": "H2O + N(tele)-phospho-L-histidyl-[protein] <=> L-histidyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807106", "l": "PTEN undergoes monoubiquitination (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52036", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate = L-isoleucine + tuberonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8937792", "l": "RUNX3 binds SRC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70916", "l": "guanosine(in) + H(+)(in) => guanosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15153", "l": "4-hydroxybenzoate + UDP-alpha-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.194", "l": "\"4-hydroxybenzoate 4-O-beta-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15818", "l": "H2O + O2 + pyridoxamine 5'-phosphate => H2O2 + NH4(+) + pyridoxal 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14821", "l": "beta-L-arabinopyranose = L-ribulose", "d": [], "t": []}, {"i": "EC:5.3.1.4", "l": "\"L-arabinose isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097260", "l": "eoxin A4 synthase activity", "d": ["Catalysis of the reaction: leukotriene A4 = eoxin A4."], "t": []}, {"i": "REACT:R-HSA-2162019", "l": "LTA4 is converted to EXA4 by ALOX15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3772436", "l": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097261", "l": "eoxin C4 synthase activity", "d": ["Catalysis of the reaction: eoxin A4 + glutathione = eoxin C4."], "t": []}, {"i": "REACT:R-HSA-2161768", "l": "EXA4 is converted to EXC4 by LTC4S (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664850", "l": "ATM binds PEX5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65869", "l": "Delta(1)-dihydrotestosterone + H2O => 1,17beta-dihydroxyandrostan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43535", "l": "a ribonucleoside 3',5'-bisphosphate + H2O <=> a ribonucleoside 5'-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47265", "l": "2,6,10,14-tetramethylpentadecanoate + ATP + CoA => AMP + diphosphate + pristanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14399", "l": "(4Z)-2-oxohept-4-enedioate + CO2 => (3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31902", "l": "indole + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + indolin-2-one + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21055", "l": "(S)-2-hydroxypropyl-coenzyme M + NAD(+) <=> 2-oxopropyl-coenzyme M + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1013020", "l": "Activation of GIRK/Kir3 Channels (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6790038", "l": "Expression of HSP90B1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42370", "l": "H(+) + 2 H2O + monacolin L carboxylate + oxidized [NADPH--hemoprotein reductase] => dihydromonacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41707", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphate + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60415", "l": "H2O + monoglucosyl-enterobactin <=> [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753634", "l": "GGT dimers hydrolyse APAP-SG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36235", "l": "1-O-alkyl-sn-glycero-3-phosphate + an acyl-CoA = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-203700", "l": "eNOS translocation from Golgi to Caveolae (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023884", "l": "NCOA1 recruits EP300 to TGFA promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41402", "l": "1-hexanoyl-sn-glycero-3-phosphate + choline + H(+) => 1-hexanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15435", "l": "diphosphate + sophoraflavanone B => (2S)-naringenin + dimethylallyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47720", "l": "H(+) + H2O + isoguanine = NH4(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56547", "l": "H2O + N-hexadecanoyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine <=> a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76352", "l": "oxaloacetate(in) + sulfate(out) => oxaloacetate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37410", "l": "(9Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine <=> 1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.383", "l": "\"ketol-acid reductoisomerase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043878", "l": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity", "d": ["Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874435", "l": "THEM86B hydrolyses PMCHO, PMETAM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932955", "l": "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44040", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = 14,15-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8941543", "l": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40646", "l": "1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4568848", "l": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35185", "l": "4-carboxy-2-thioxobutanoyl-CoA => 5-hydroxythiophene-2-carbonyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74770", "l": "S-adenosyl-L-methionine + syringetin <=> 3,3',5'-O-trimethylmyricetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35702", "l": "(S)-versiconol + NADP(+) <=> (2S-3S)-versiconal hemiacetal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003832", "l": "beta-alanyl-dopamine hydrolase activity", "d": ["Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395512", "l": "FDXR transfers electrons to FDX1,2 (FDX1L) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77609", "l": "Binding of APOBEC-1 to form editosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.2.4", "l": "\"NADPH--hemoprotein reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29797", "l": "ADP(in) + H(+)(in) + phosphate(in) + Zn(2+)(in) => ATP(in) + H2O(in) + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66600", "l": "2 dopamine + O2 = 2 dopamine quinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47041", "l": "5-taurinomethyluridine(34) in tRNA + AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] => 5-taurinomethyl-2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34218", "l": "4-oxo-4-(pyridin-3-yl)butanal + H2O + NADP(+) <=> 4-oxo-4-(pyridin-3-yl)butanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9853878", "l": "FIGNL1 binds DMC1, RAD51 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719424", "l": "PIAS1 SUMOylates THRB with SUMO1. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21760", "l": "(3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA", "d": [], "t": []}, {"i": "EC:5.1.2.3", "l": "\"3-hydroxybutyryl-CoA epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63873", "l": "2-oxoglutarate + L-isoleucine + O2 => 3(1)-hydroxy-L-isoleucine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018808", "l": "RAC3 binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61125", "l": "kaempferol + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68424", "l": "(3R)-3-hydroxy-10'-apo-beta-carotenal + O2 = (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.150", "l": "\"N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.5.1.2", "l": "\"DNA ligase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39429", "l": "(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA + NADP(+) => (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11266", "l": "H2O2 + NAD(+) => H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8850945", "l": "Casein kinase II phosphorylates PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48870", "l": "AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide => H2O + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.56", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31150", "l": "3,4-dihydroxyphenylethyleneglycol + NAD(+) <=> 3,4-dihydroxymandelaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106378", "l": "2-hydroxy-dATP hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374689", "l": "Neogenin binds Netrin-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9753944", "l": "ACY1:Zn2+ dimer deacetylates NAC to L-Cys (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72085", "l": "ADP-alpha-D-ribose 1''-phosphate + H(+) => ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32485", "l": "CO2 + methanol + pyropheophorbide a => H(+) + H2O + pheophorbide a", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13959", "l": "6 H(+) + 2 hydrogen sulfide + 2 sulfite => 4 H2O + O2 + 4 sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944216", "l": "Association of procollagen type XV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56041", "l": "H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-166726", "l": "Activation of MASPs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50086", "l": "ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out) => ATP + H2O + taurolithocholate 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49089", "l": "FAD + H(+) + H2O + squalene => FADH2 + hydroxysqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71128", "l": "H(+)(in) + L-glutamine(out) + Na(+)(out) => H(+)(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55385", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate => 6 diphosphate + tetra-trans,hexa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71445", "l": "PGAM dimers (PGAM1,2) isomerise 2PG to 3PG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964619", "l": "PAK1 binds ARHGEF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0004129", "l": "cytochrome-c oxidase activity", "d": ["Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354173", "l": "Activation of Rap1 by cytosolic GEFs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14153", "l": "17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.39", "l": "\"steroid N-acetylglucosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877475", "l": "TRAPPC complexes exchange GTP for GDP on RAB1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-388503", "l": "Oxytocin receptor bind oxytocin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102525", "l": "2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity", "d": ["Catalysis of the reaction: L-argininium(1+) + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-arginine(1+) + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48866", "l": "FAD + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine => 2-methylpropan-1-amine + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5689861", "l": "Recruitment of XPA and release of CAK  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9677929", "l": "MAOB inhibitors bind MAOB:FAD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202604", "l": "Formation of a heteromeric BMP receptor complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730664", "l": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103097", "l": "CYP79F1 trihomomethionine monooxygenase activity", "d": ["Catalysis of the reaction: trihomomethionine + 2 O2 + 2 NADPH + 2 H+ = 3 H2O + carbon dioxide + 2 NADP + 6-methylthiohexanaldoxime."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640195", "l": "RRAGA,B hydrolyzes GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33346", "l": "glycine + O2 <=> 2-iminoacetate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27790", "l": "2-all-trans-octaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018664", "l": "benzoate 4-monooxygenase activity", "d": ["Catalysis of the reaction: benzoate + H+ + NADPH + O2 = 4-hydroxybenzoate + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390593", "l": "ATP Hydrolysis By Myosin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654425", "l": "Activated FGFR4 binds SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51525", "l": "(S)-corytuberine + S-adenosyl-L-methionine => magnoflorine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784791", "l": "p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39313", "l": "(3R)-hydroxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+) => (8Z,11Z,14Z)-3-oxoeicosatrienoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44127", "l": "hexadecanoyl-CoA + tetradecan-1-ol <=> CoA + tetradecanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421493", "l": "succinyl-CoA + glycine => delta-aminolevulinate + CoA SH + CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62551", "l": "a neolactoside IV(3)-beta-GlcNAc-nLc4Cer + UDP-alpha-D-galactose <=> beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18628", "l": "D-galactose + NADP(+) <=> D-galactono-1,5-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50776", "l": "hexanal + NADP(+) = (E)-hex-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621571", "l": "CD209 binds ICAM2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449077", "l": "Interleukin-16 is secreted (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114284", "l": "Release of Cytochrome c from mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448480", "l": "IL22 binds IL22RA1:JAK1 receptor complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051750", "l": "delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity", "d": ["Catalysis of the reaction: a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25780", "l": "H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate", "d": [], "t": []}, {"i": "EC:1.1.1.336", "l": "\"UDP-N-acetyl-D-mannosamine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196950", "l": "2xTRAP hydrolyzes FMN to RIB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5671772", "l": "p-T38-PPP1R14A binds MLCP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761849", "l": "AcK-NFE2L2-dependent P6GD gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8864569", "l": "WWOX binds TFAP2C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67042", "l": "asnovolin H => (3R)-[(10S)-11-epoxyfarnesyl]-2,3,5-trimethyl-6-oxido-4-oxocyclohexa-1,5-diene-1-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31473", "l": "beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP => beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937631", "l": "CRHR2-2 binds CRH,UCN,UCN2,UCN3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39071", "l": "dodecanedioyl-CoA + O2 = (2E)-dodecenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3240295", "l": "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730863", "l": "Phosphorylation of CARMA1 by PKC-theta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-217147", "l": "Phosphorylation of c-Abl and Arg by ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67675", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + a 1-acyl-sn-glycero-3-phosphocholine <=> a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72926", "l": "O2 + proatranorin II + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + proatranorin III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78028", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol => a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192051", "l": "CYP7A1 7-hydroxylates CHOL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043749", "l": "phenol, water dikinase activity", "d": ["Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65279", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone <=> 2alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72208", "l": "chloride(out) + 2 hydrogencarbonate(in) => chloride(in) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805276", "l": "CDK5 phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50808", "l": "glutathione + prostaglandin J2 = prostaglandin J2-S-(S)-glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690790", "l": "Histone H2A is dubiquitinated by the PR-DUB complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050558", "l": "maltose epimerase activity", "d": ["Catalysis of the reaction: alpha-maltose = beta-maltose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-983158", "l": "Trimming of peptides in ER (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19192", "l": "H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + pyruvate <=> CO2 + N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008918", "l": "lipopolysaccharide 3-alpha-galactosyltransferase activity", "d": ["Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195304", "l": "Association of beta-catenin with the destruction complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49054", "l": "asperlicin E + H2O + NAD(+) => asperlicin C + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40752", "l": "(9Z)-octadecenoate + 1-hexadecanoylglycerone 3-phosphate => 1-(9Z)-octadecenoylglycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57561", "l": "(+)-cis-trans-nepetalactol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 7-deoxyloganetate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3968362", "l": "SUMOylation of PIAS4 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19307", "l": "2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA => 3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55154", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + 2 reduced [electron-transfer flavoprotein] => H(+) + L-prolyl-[peptidyl-carrier protein] + 2 oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198315", "l": "Active IRS recruits PI3K to the plasma membrane and activates it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693356", "l": "CEMIP hydrolyses HA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9005585", "l": "MECP2 mutants P302R,K304E,K305R,R306C,(R306H) do not bind NCoR/SMRT complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18239", "l": "3-maleylpyruvate + H(+) => 2,5-dihydroxybenzoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693742", "l": "FAAH hydrolyses AEA to AA and ETA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.9", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25992", "l": "(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.37", "l": "\"epi-isozizaene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30455", "l": "(1S,4aS)-1,4a-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalene + H2O = (-)-geosmin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5693549", "l": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77982", "l": "all-trans-hexaprenyl diphosphate + H2O <=> colleterpenol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035517", "l": "Defective AVP mutants do not bind AVPR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75942", "l": "4-aminobutanoate + L-arginine <=> 4-guanidinobutanoate + L-ornithine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28075", "l": "(2R)-3-sulfopropanediol + H2O + 2 NAD(+) => (2R)-3-sulfolactate + 3 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77186", "l": "L-threonine + uridine-5'-aldehyde <=> (5'S,6'S)-C-glycyluridine + acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74924", "l": "a (3R)-3-[(carboxymethyl)amino]fatty acid + H(+) + holo-[ACP] => a (2E)-enoyl-[ACP] + glycine + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61532", "l": "ent-kaur-16-ene + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = ent-kaur-16-en-19-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46578", "l": "2 H2O + NADP(+) + stigmasterol => H(+) + NADPH + O2 + sitosterol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36364", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 H(+) + 2 NADPH => (9Z,12Z)-octadecadien-1-ol + CoA + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.-.-", "l": "\"Carbon-sulfur lyases\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9696267", "l": "RND3 binds GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634442", "l": "KLF5 gene expression is enhanced by CEBPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989767", "l": "Expression of TRIB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003979", "l": "UDP-glucose 6-dehydrogenase activity", "d": ["Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050376", "l": "UDP-glucosamine 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-glucosamine = UDP-galactosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25203", "l": "D-arabino-hex-3-ulose 6-phosphate => D-ribulose 5-phosphate + formaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8940561", "l": "MMP7 cleaves OPTC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158747", "l": "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983061", "l": "TSLP binds CRLF2:IL7R (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2534096", "l": "METAP1/2 demethylates GNAT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034807", "l": "4,5-dihydroxybenzo(a)pyrene methyltransferase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + C1 unit = hydroxymethoxybenzo(a)pyrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47169", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) => 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34887", "l": "selenate(in) = selenate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13073", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.40", "l": "\"guanosine-5'-triphosphate,3'-diphosphate diphosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090483", "l": "phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity", "d": ["Catalysis of the reaction: phosphatidylglycerol + phosphatidylethanolamine = cardiolipin + ethanolamine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9674127", "l": "USP30 deubiquitinates ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45401", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => (9Z)-octadecenoate + H(+) + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624789", "l": "pro-SFTPB translocates from ER membrane to multivesicle body (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5621355", "l": "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59549", "l": "N,N',N''-triacetylchitotriose + O2 => H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71024", "l": "L-leucine(in) + L-phenylalanine(out) => L-leucine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11580", "l": "a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.11", "l": "\"CDP-diacylglycerol--inositol 3-phosphatidyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.-.-", "l": "\"Acting on the CH-OH group of donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44383", "l": "a 3-demethylubiquinol + S-adenosyl-L-methionine <=> a ubiquinol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070675", "l": "hypoxanthine oxidase activity", "d": ["Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2."], "t": []}, {"i": "REACT:R-HSA-74247", "l": "XDH oxidizes hypoxanthine to form xanthine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14148", "l": "ATP + guanidinoacetate <=> ADP + H(+) + phosphoguanidinoacetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44977", "l": "(R)-carnitine + propanoyl-CoA => CoA + O-propanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69691", "l": "a ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine = a ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.19", "l": "\"carboxypeptidase Taq\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9640060", "l": "KCNIP3 binds NPAS4 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41385", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71470", "l": "H2O + substance P <=> L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-7)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.101", "l": "\"acylglycerone-phosphate reductase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35639", "l": "(4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140610", "l": "RNA sequestering activity", "d": ["Binding to a specific RNA molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.27", "l": "\"O-antigen polymerase Wzy\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45025", "l": "cholesterol + H(+) + NADPH + O2 => 7-dehydrocholesterol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983384", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36572", "l": "sphinganine + tetradecanoyl-CoA => CoA + H(+) + N-(tetradecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75779", "l": "(6Z,9Z,12Z,15Z)-octadecatetraenoate + H2O = (10S)-hydroxy-(6Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031802", "l": "Maresins translocate from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.110", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51893", "l": "H2O + N-acetylcadaverine => acetate + cadaverine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026007", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139893", "l": "Granzyme-B activates BID by cleavage (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961946", "l": "E2F1 binds the CDT1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61514", "l": "malvidin 3-O-beta-D-glucoside + UDP => malvidin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65603", "l": "4,5,8-trihydroxycasbene + 2 NAD(+) <=> 2 H(+) + jolkinol C + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6807864", "l": "RAB1:GTP recruits GBF1 to the ERGIC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68310", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate => 1D-myo-inositol hexakisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62789", "l": "2 fonsecin B + H(+) + NADPH + O2 => aurasperone B + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62311", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide B + FADH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17980", "l": "a long-chain primary fatty alcohol + H2O + 2 NAD(+) <=> a long-chain fatty acid + 3 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39912", "l": "(2S,3S)-3-methylphenylalanine + 2-oxoglutarate => (3S)-2-oxo-3-phenylbutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853252", "l": "CR2:C3d,C3dg,iC3b binds CD19:CD81 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67980", "l": "beta-zeacarotene = 7,8-dihydro-beta-carotene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675813", "l": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43187", "l": "S-adenosyl-L-methionine + uridine(2843) in 25S rRNA <=> H(+) + N(3)-methyluridine(2843) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482827", "l": "PC is hydrolyzed to 2-acyl LPC by PLA2G4C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-189439", "l": "ALAD condenses 2 dALAs to form PBG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70895", "l": "N-terminal L-cysteinyl-[protein] + O2 = H(+) + N-terminal S-hydroxy-S-oxy-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.841068507151263", "identifiers": [{"i": "GO:0015645", "l": "fatty acid ligase activity", "d": ["Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71802", "l": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694462", "l": "ABHD6,12 hydrolyse 3AG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74248", "l": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627078", "l": "XIAP binds CASP9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.358", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60242", "l": "CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685290", "l": "SFTPD gene produces SFTPD protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52981", "l": "a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] => 7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42727", "l": "guanosine(2922) in 27S pre-rRNA + S-adenosyl-L-methionine <=> 2'-O-methylguanosine(2922) in 27S pre-rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79158", "l": "(4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside(in) + ATP + H2O <=> (4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69306", "l": "(Z)-phenyl-N-(sulfonatooxy)methanimidothioate + D-glucose + H(+) => (Z)-glucotropeolin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9854315", "l": "CSKMT methylates Citrate Synthase (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052794", "l": "exo-alpha-(2->3)-sialidase activity", "d": ["Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16907", "l": "a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44534", "l": "1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64921", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + H2O => a 2'-deoxyribonucleoside 5'-phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-158484", "l": "Release of the SLBP independent Histone mRNA from the NPC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28719", "l": "adenine(in) + H(+)(in) = adenine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129385", "l": "MFAP2, MFAP5 bind microfibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19242", "l": "ent-kaur-16-en-19-oate + O2 + reduced [NADPH--hemoprotein reductase] => ent-7alpha-hydroxykaur-16-en-19-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61426", "l": "cis-cis-nepetalactone + H(+) + NADH => cis-cis-nepetalactol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034839", "l": "menth-2-enone hydratase activity", "d": ["Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64215", "l": "an N-(fatty acyl)-L-isoleucine + H2O <=> a fatty acid + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75900", "l": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637792", "l": "PLC-gamma 1 binds to p-EGFRvIII mutant (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3769383", "l": "CBY1 binds beta-catenin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9732527", "l": "FFAR1 binds rosiglitazone (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9844955", "l": "CLN3 transports GalCer to plasma membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41526", "l": "5 CO2 + 5 CoA + H2O + naphthalene-1,3,6,8-tetrol => 5 H(+) + 5 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-629599", "l": "Binding of acetylcholine to highly calcium permeable acetylcholine receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50996", "l": "L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[ribulose-1,5-bisphosphate carboxylase] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.127", "l": "\"[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849042", "l": "PTK6 phosphorylates KHDRBS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861788", "l": "GBA2 hydrolyzes GlcCer (plasma membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8876868", "l": "ECE1 cleaves EDN1(53-90) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9907144", "l": "MITF-M dimer and TFAP2A bind the IRF4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33411", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O = (S)-malyl alpha-D-glucosaminide + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862700", "l": "CMKLR1 binds Resolvin E1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050128", "l": "N-feruloylglycine deacylase activity", "d": ["Catalysis of the reaction: N-feruloylglycine + H2O = ferulate + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351434", "l": "Phosphorylation of H2AX at S139 by ATM at the site of DSB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102720", "l": "acetyl-coenzyme A:acetyl alcohol acetyltransferase activity", "d": ["Catalysis of the reaction: benzyl alcohol + acetyl-CoA = benzyl acetate + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37435", "l": "(9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphate = a 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442724", "l": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21214", "l": "4-hydroxy-2-oxobutanal + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46080", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADH = NAD(+) + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693390", "l": "HSD17B11 dehydrogenates EST17b to E1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68341", "l": "(R)-4'-phospho-S-sulfopantetheine + H2O => (R)-S-sulfopantetheine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9755078", "l": "NT5C2 tetramer dephosphorylates RBV-MP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-936991", "l": "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42250", "l": "3-oxohexanoyl-[ACP] + CO2 + CoA => butanoyl-CoA + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49804", "l": "2-methylpropan-1-amine + FMNH2 + O2 = FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450474", "l": "MK2 phosphorylates BRF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35646", "l": "a (2R)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165708", "l": "Dissociation of phosphorylated 4EBP1 from eIF4E (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047136", "l": "4-(dimethylamino)phenylazoxybenzene reductase activity", "d": ["Catalysis of the reaction: 4-(dimethylamino)azobenzene + H2O + NADP+ = 4-(dimethylamino)phenylazoxybenzene + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110360", "l": "Recruitment of POLB to the AP site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140953", "l": "histone H3K27 monomethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl27-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl27-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 27 of histone H3, producing histone H3K27me."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744242", "l": "TTYH2/3 transport cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23216", "l": "benzoyl-CoA + H(+) + NADPH + O2 = 3-hydroxybenzoyl-CoA + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.58", "l": "\"benzoyl-CoA 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22553", "l": "3'-phosphoadenylyl sulfate + an alcohol => adenosine 3',5'-bisphosphate + an alkyl sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5687758", "l": "PPP4C:PPP4R2 dephosphorylates RPA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79117", "l": "L-arginocholate + taurine => L-arginine + taurocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48176", "l": "decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1112755", "l": "SOCS3 binds IL6ST (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429961", "l": "DCPS scavenges the 7-methylguanosine cap of mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9696267", "l": "RND3 binds GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6792863", "l": "PP2A-PP2R5C dephosphorylates MDM2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-83805", "l": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800870", "l": "NDUF subunits bind to form the FP subcomplex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41476", "l": "an acyl-CoA + zymosterol = CoA + zymosterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.37", "l": "\"gingipain R\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649658", "l": "NEIL1 cleaves DHU from damaged DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68595", "l": "ORC2 binds ORC3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69142", "l": "Recruitment of Dna2 endonuclease (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33371", "l": "alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] = alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.201", "l": "\"protein-N(pi)-phosphohistidine--trehalose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68746", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022A + 4 S-adenosyl-L-homocysteine => 2 (R)-3-phenyllactate + 2 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676593", "l": "TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9007283", "l": "CBX3 and PRC1.6 associate with E2F6.com-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-351341", "l": "Exocytosis of Proactivator polypeptide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012000", "l": "NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-382560", "l": "ABC7, mABC1 and mABC2 mediate heme transport (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-420688", "l": "GABAB heterodimeric receptor binds GABA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-211960", "l": "CYP2U1 19-hydroxylates ARA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77345", "l": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50246", "l": "3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56415", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668731", "l": "NOX3 complex:RAC1:GTP generates superoxide from oxygen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32751", "l": "choline(out) = choline(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001965", "l": "G-protein alpha-subunit binding", "d": ["Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "56.292151461937877", "identifiers": [{"i": "GO:0016705", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor."], "t": []}, {"i": "EC:1.14.-.-", "l": "\"Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047670", "l": "anhydrotetracycline monooxygenase activity", "d": ["Catalysis of the reaction: anhydrotetracycline + H+ + NADPH + O2 = 12-dehydrotetracycline + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9632918", "l": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399997", "l": "AKT1 E17K mutant translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34684", "l": "alpha-D-ribose 1-methylphosphonate 5-triphosphate + H2O => alpha-D-ribose 1-methylphosphonate 5-phosphate + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482647", "l": "2-MAG and DAG are transacylated to TAG by PNPLA2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39236", "l": "(3R)-hydroxytriacontanoyl-CoA => (2E)-triacontenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418904", "l": "A1 and A3 receptors bind adenosine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25251", "l": "(2S)-2-acetolactate + CO2 => H(+) + 2 pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16367", "l": "2 3,4,5-trihydroxybenzoate + H(+) => digallate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857692", "l": "RNA demethylases demethylate N6-methyladenosine RNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76624", "l": "(R)-2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) => H(+) + hydrogencarbonate + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322427", "l": "Beta-catenin recruits CBP/p300 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070974", "l": "POU domain binding", "d": ["Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482856", "l": "PC is hydrolyzed to 1-acyl LPC by PLA2[5] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034567", "l": "chromate reductase activity", "d": ["Catalysis of the reaction: chromate = chromium (III)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69173", "l": "Joining of adjacent Okazaki fragments (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189208", "l": "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944219", "l": "Association of procollagen type XVI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71181", "l": "FAH cleaves 4FAA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982026", "l": "G alpha (q):RGS dissociates to inactive G alpha (q) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34752", "l": "ATP + N-acyl-15-methylhexadecasphing-4-enine => ADP + H(+) + N-acyl-15-methylhexadecasphing-4-enine-1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55220", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}, {"i": "EC:1.14.18.9", "l": "\"4alpha-methylsterol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950213", "l": "Expression of Phosphatidylinositol transfer protein alpha isoform (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851011", "l": "TRIM27 polyubiquitinates PTEN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106140", "l": "P-TEFb complex binding", "d": ["Binding to a P-TEFb complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30747", "l": "FAD + H(+) + hexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9727300", "l": "9b homodimer localizes to the mitochondrial outer membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2545253", "l": "Deacetylation of cohesin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109449", "l": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177275", "l": "PKA phosphorylates DARPP-32 on Thr34 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9014741", "l": "PXLP-K56-SRR dimer deaminates D-Ser (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34095", "l": "carboxyspermidine + H(+) = CO2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427555", "l": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35514", "l": "glycyrrhetaldehyde + O2 + reduced [NADPH--hemoprotein reductase] <=> glycyrrhetinate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45499", "l": "phycocyanobilin-L-cysteinyl(84)-[allophycocyanin alpha-subunit] <=> (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[allophycocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166726", "l": "Activation of MASPs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40630", "l": "H2O + trihexadecanoylglycerol <=> 2,3-dihexadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19305", "l": "3-hydroxybenzoyl-CoA + 2 H(+) + 3 malonyl-CoA = 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 + 4 CoA", "d": [], "t": []}, {"i": "EC:2.3.1.151", "l": "\"2,3',4,6-tetrahydroxybenzophenone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373875", "l": "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78468", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP-N-acetyl-beta-neuraminate => a ganglioside GM3 + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9012835", "l": "GDIs block activation of RHOA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5357757", "l": "BIRC(cIAP1/2) ubiquitinates RIPK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60850", "l": "a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + L-lysyl-[protein] => a 5'-end diphospho-guanosine in mRNA + 2 H(+) + N(epsilon)-GMP-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607043", "l": "factor VIIIa associates with cell membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63135", "l": "apo-[alkylcobalamin reductase] + glutathione + methylcob(III)alamin <=> cob(I)alamin-[alkylcobalamin reductase] + H(+) + S-methyl glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68726", "l": "26-oxolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 26-hydroxylanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381435", "l": "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5685230", "l": "CHEK1 phosphorylates RAD51 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004486", "l": "methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.134", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-373705", "l": "Caspase cleavage of DCC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10209", "l": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) => H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.1.1.11", "l": "\"serine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102105", "l": "demethoxycurcumin synthase activity from feruloylacetyl-CoA", "d": ["Catalysis of the reaction: feruloylacetyl-CoA + 4-coumaryl-CoA + H2O = demethoxycurcumin + 2 coenzyme A + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1295599", "l": "SPRY2 translocates to the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27625", "l": "geranylgeranyl diphosphate + 7 isopentenyl diphosphate <=> 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043823", "l": "spheroidene monooxygenase activity", "d": ["Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9009526", "l": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052720", "l": "class II DNA-(apurinic or apyrimidinic site) endonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26506", "l": "(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800793", "l": "PIDD1 translocates to the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51588", "l": "isopyridoxal + NAD(+) = 5-pyridoxolactone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.416", "l": "\"isopyridoxal dehydrogenase (5-pyridoxolactone-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099579", "l": "G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential", "d": ["A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52731", "l": "3'-phosphoadenylyl sulfate + a 12-hydroxyjasmonate <=> a 12-sulfojasmonate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033830", "l": "Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylglucosamine + Skp1-protein-hydroxyproline = UDP + Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1433454", "l": "Phosphorylation of GAB2 by SFKs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10450", "l": "a flavone + CO2 + H2O + succinate => 2-oxoglutarate + a flavanone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033766", "l": "2-hydroxyquinoline 8-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + NADH + O2 + quinolin-2-ol = H2O + NAD+ + quinoline-2,8-diol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-432121", "l": "LDL binds to LRP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58975", "l": "H2O + O2 + vanillin <=> H(+) + H2O2 + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17593", "l": "3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine", "d": [], "t": []}, {"i": "EC:2.6.1.64", "l": "\"glutamine--phenylpyruvate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24037", "l": "a ribonucleoside 5'-phosphate + ATP => a ribonucleoside 5'-diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39940", "l": "1,3-di-(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875817", "l": "MET phosphorylates STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62562", "l": "(4R)-perillyl alcohol + AH2 => (4R)-limonene + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52113", "l": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA => 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683670", "l": "Protein E forms a homopentamer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56522", "l": "2 5'-deoxyadenosine + 2 CO2 + heme b + 2 L-methionine => Fe-coproporphyrin III + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19584", "l": "N(6)-dimethylallyladenine + S-adenosyl-L-methionine <=> discadenine + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76678", "l": "1-deoxysphinganine + a fatty acyl-CoA <=> CoA + H(+) + N-acyl-1-deoxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047198", "l": "cysteine-S-conjugate N-acetyltransferase activity", "d": ["Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25869", "l": "H2O + N(1),N(12)-diacetylspermine + O2 => 3-acetamidopropanal + H2O2 + N(1)-acetylspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9707594", "l": "Hemes bind LY96 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50325", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + O2 + reduced [NADPH--hemoprotein reductase] => 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050031", "l": "L-pipecolate oxidase activity", "d": ["Catalysis of the reaction: L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19454", "l": "2-oxoglutarate + L-alanine => L-glutamate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442732", "l": "NMDA-activated RASGRF1 activates RAS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23987", "l": "cholesterol + NADP(+) <=> 7-dehydrocholesterol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.9", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396399", "l": "Fibrillins bind BMPs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50492", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110371", "l": "LIG1 binds APEX1 and PCNA at SSB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-170120", "l": "Translocation of Cdc25B to the cytoplasm (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36768", "l": "2-hydroxytetracosenoyl-CoA + sphinganine => CoA + H(+) + N-(2-hydroxytetracosenoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77078", "l": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60244", "l": "2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = 2 AH2 + 2 formaldehyde + L-lysyl(4)-[histone H3]", "d": [], "t": []}, {"i": "EC:1.14.99.66", "l": "\"[histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173542", "l": "SMURF2 ubiquitinates SMAD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57736", "l": "A + all-trans-3,4-didehydro-13,14-dihydroretinol = AH2 + all-trans-3,4-didehydroretinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41287", "l": "H2O + N-tetradecanoylsphing-4-enine = sphing-4-enine + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65465", "l": "2-methylbutan-1-ol + butanoyl-CoA => 2-methylbutyl butanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.1.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14007", "l": "2-oxobutanoate + L-cysteine + NH4(+) => H2O + L,L-cystathionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-449117", "l": "TXLNA (IL14) binds syntaxin1A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.39", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75265", "l": "3''-dehydroisovitexin + H2O2 => isovitexin + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691381", "l": "MYSM1 deubiquitinates Histone H2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448661", "l": "IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41708", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphoethanolamine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphoethanolamine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018858", "l": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37889", "l": "H(+) + S-adenosyl-L-homocysteine + small RNA 3'-end 2'-O-methylnucleotide => S-adenosyl-L-methionine + small RNA 3'-end nucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051743", "l": "red chlorophyll catabolite reductase activity", "d": ["Catalysis of the reaction: red chlorophyll catabolite + reduced ferredoxin + 2 H+ = primary fluorescent catabolite + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite (RCC) to a colorless tetrapyrrole (pFCC) with a strong blue fluorescence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50634", "l": "a 2-(omega-methylsulfanyl)alkylmaleate + H2O => a 2-(omega-methylsulfanyl)alkylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2064418", "l": "WWTR1 (TAZ) binds ZO-2 (TJP2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75859", "l": "all-trans-4-hydroxy-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-4-oxo-13,14-dihydroretinoate + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51769", "l": "2-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one + dimethylallyl diphosphate => 4-prenylphlormethylbutanophenone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27680", "l": "ADP + dCTP => ATP + dCDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-879459", "l": "F-actin capping protein is a heterodimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9700168", "l": "Active ALK phosphorylates IRS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9645220", "l": "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-354060", "l": "Translocation of RIAM to plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39426", "l": "(3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA <=> (2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13046", "l": "ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050295", "l": "steryl-beta-glucosidase activity", "d": ["Catalysis of the reaction: cholesteryl-beta-D-glucoside + H2O = D-glucose + cholesterol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693111", "l": "RHOF auto-activates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640862", "l": "Tankyrase binds AXIN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1592362", "l": "Activation of proMMP7 by MMP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202947", "l": "Caspase mediated cleavage of APC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2400010", "l": "AKT inhibitors block AKT membrane recruitment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12861", "l": "guanosine + H(+) + H2O = NH4(+) + xanthosine", "d": [], "t": []}, {"i": "EC:3.5.4.15", "l": "\"guanosine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48452", "l": "a ganglioside GA2 (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28744", "l": "nitrate(in) + nitrite(out) => nitrate(out) + nitrite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374663", "l": "DCC interaction with Ezrin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62189", "l": "9alpha-copalyl diphosphate => diphosphate + syn-isopimara-7,15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11453", "l": "7-deoxyloganin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + loganin + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55608", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + a mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol phosphomannosylnositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41107", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-octadecanoyl-sn-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951977", "l": "Acetylated RUNX3 binds to BRD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983835", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63324", "l": "1,2-dihexadecanoyl-sn-glycerol + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34900", "l": "malonyl-CoA + S-adenosyl-L-methionine => malonyl-CoA methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032181", "l": "dinucleotide repeat insertion binding", "d": ["Binding to a double-stranded DNA region containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18152", "l": "H2O + N-acetyl-D-galactosamine 6-phosphate <=> acetate + D-galactosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3769397", "l": "SOST binds LRP5/6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016361", "l": "activin receptor activity, type I", "d": ["Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.3", "l": "\"aldose 1-epimerase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22223", "l": "ent-copalyl diphosphate <=> diphosphate + ent-kaur-16-ene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014293", "l": "RAC2 GDIs block activation of RAC2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11031", "l": "ATP + D-mannose <=> ADP + D-mannose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29419", "l": "H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174445", "l": "RPA binds to the Flap on the C-strand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977619", "l": "CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351913", "l": "Caspase-mediated cleavage of TJP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60133", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 => a (8S,9S)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64666", "l": "a long-chain fatty acyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+) => a long-chain fatty acyl-AMP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71491", "l": "an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(in) = an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52466", "l": "17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP => 17beta-estradiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12347", "l": "(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) <=> H(+) + L-glutamyl-tRNA(Glu) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166726", "l": "Activation of MASPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250383", "l": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614362", "l": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9754129", "l": "CDK6 inhibitors bind CDK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700168", "l": "Active ALK phosphorylates IRS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031734", "l": "CCR9 chemokine receptor binding", "d": ["Binding to a CCR9 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0004528", "l": "phosphodiesterase I activity", "d": ["Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56918", "l": "5alpha-androstan-3,17-dione + H(+) + NADPH => 3beta-hydroxy-5alpha-androstan-17-one + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008327", "l": "methyl-CpG binding", "d": ["Binding to a methylated cytosine/guanine dinucleotide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964773", "l": "OXGR1 binds 2OG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21853", "l": "(R)-10-hydroxyoctadecanoate => (9Z)-octadecenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10053", "l": "(R)-2-hydroxy-4-methylpentanoate + NAD(+) => 4-methyl-2-oxopentanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16094", "l": "(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247843", "l": "secretion of WNT ligands (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102689", "l": "UDP-glucose:isopentenyladenine 7-N-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine = H+ + 7-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8934819", "l": "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22839", "l": "a fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70745", "l": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5685230", "l": "CHEK1 phosphorylates RAD51 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428518", "l": "Glypican-1 (GPC1) binds SLIT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36008", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21761", "l": "(3S)-3-hydroxybutanoyl-CoA => (3R)-3-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011748", "l": "IL9R binds JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35555", "l": "cyclo(L-leucyl-L-leucyl) + 4 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] = 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] + pulcherriminic acid", "d": [], "t": []}, {"i": "EC:1.14.15.13", "l": "\"pulcherriminic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.95", "l": "\"snake venom factor V activator\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8851908", "l": "Activated MET binds GAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1297444", "l": "Binding of cAMP to HCN channels (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25288", "l": "4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => lanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.7", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3245898", "l": "TCN1 binds correnoids in the circulation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62515", "l": "2-oxoglutarate + melatonin + O2 <=> 2-hydroxymelatonin + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76342", "l": "2 Na(+)(out) + urate(out) <=> 2 Na(+)(in) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938773", "l": "RNF144A polyubiquitinates PRKDC (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-381503", "l": "IGFBP6 binds IGF forming IGF:IGFBP6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32027", "l": "(2E,6E)-farnesyl diphosphate = (-)-alpha-cuprenene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.95", "l": "\"(-)-alpha-cuprenene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47757", "l": "guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine => 2'-O-methylguanosine(1370) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418456", "l": "cGMP is degraded by PDEs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692749", "l": "CDC14A,B bind MAPK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35878", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69775", "l": "(2E,6E)-farnesyl diphosphate = beta-ylangene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202969", "l": "Caspase mediated cleavage of beta-catenin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5625717", "l": "Phosphorylated PKN1 binds androgen receptor (AR) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433423", "l": "PTP-RO interacts with p-c-Kit complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44809", "l": "1,4-dihydroxy-2-naphthoate + all-trans-decaprenyl diphosphate + H(+) => 2-demethylmenaquinol-10 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390425", "l": "FAR1 reduces PalmCoA to HXOL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45926", "l": "4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA => 9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9858752", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53804", "l": "allodeoxycholoyl-CoA + ursodeoxycholate = allodeoxycholate + ursodeoxycholoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198669", "l": "p38MAPK phosphorylates MSK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75983", "l": "(indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21829", "l": "H2O + nitrite + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + nitrate + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78796", "l": "a 3-oxoacyl-[ACP] + acetyl-[ACP] + H2O => a 3-carboxymethyl-3-hydroxy-acyl-[ACP] + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296046", "l": "KCNJs transport K+ from the extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30758", "l": "ATP + carbamate <=> ADP + carbamoyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71186", "l": "L-kynurenine(out) + L-tryptophan(in) <=> L-kynurenine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31230", "l": "di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine <=> di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1->4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40421", "l": "3,7,11,15-tetramethylhexadecanoate + CoA + H(+) => H2O + phytanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090447", "l": "glycerol-3-phosphate 2-O-acyltransferase activity", "d": ["Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = CoA + a 2-acyl-sn-glycerol 3-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9759206", "l": "ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56649", "l": "3-oxochol-4-en-24-oyl-CoA + NAD(+) => 3-oxochol-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004385", "l": "guanylate kinase activity", "d": ["Catalysis of the reaction: ATP + GMP = ADP + GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66578", "l": "4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+) => 3'-phosphoadenylyl sulfate + 4-isopropylphenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.188221489317044", "identifiers": [{"i": "GO:0016639", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP."], "t": []}, {"i": "EC:1.4.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8875540", "l": "GAB1 recruits CRK,CRKL to MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035237", "l": "corazonin receptor activity", "d": ["Combining with the neuropeptide corazonin to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25736", "l": "L-pentahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + N-hydroxy-L-pentahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17875", "l": "ADP + an R-cob(III)alamin(in) + H(+) + phosphate => an R-cob(III)alamin(out) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57435", "l": "3-methoxycatechol + O2 + reduced [NADH--hemoprotein reductase] <=> 1,2,3-trihydroxybenzene + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31205", "l": "3-oxooctanoyl-CoA + CoA => acetyl-CoA + hexanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203797", "l": "ERKs are inactivated by dual-specific phosphatases (DUSPs) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12251", "l": "NADP(+) + UDP-N-acetyl-alpha-D-muramate <=> H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-844438", "l": "NLRP1 oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4570528", "l": "SUMOylation of XPC with SUMO1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047150", "l": "betaine-homocysteine S-methyltransferase activity", "d": ["Catalysis of the reaction: L-homocysteine + glycine betaine = N,N-dimethylglycine + L-methionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53426", "l": "an N-acyl-sphingoid base + CoA + H(+) => a fatty acyl-CoA + a sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694487", "l": "M protein oligomerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983138", "l": "Transport of MHC heterotrimer to ER exit site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033959", "l": "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626681", "l": "Recruitment of transition zone proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21993", "l": "acetyl-CoA + L-lysyl-[histone] => CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9671145", "l": "DKC1 binds SHQ1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26044", "l": "acetyl-CoA + N-acetylneuraminate => CoA + N-acetyl-9-O-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299318", "l": "Activation of TASK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75188", "l": "2,5-dihydroxybenzoyl-CoA + H2O => 2,5-dihydroxybenzoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26491", "l": "a secondary nitroalkane + H2O + O2 => a ketone + H(+) + H2O2 + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58407", "l": "hexan-1-ol + NADP(+) <=> H(+) + hexanal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31034", "l": "2-cis-(+)-abscisate + UDP-alpha-D-glucose <=> beta-D-glucopyranosyl cis-(+)-abscisate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659899", "l": "Defective SI does not hydrolyze maltotriose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103006", "l": "9,10-dihydroxystearate hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (9R,10S)-dihydroxystearate + O2 + NADPH = 9,10,18-trihydroxystearate + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1839100", "l": "p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43242", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0043843", "l": "ADP-specific glucokinase activity", "d": ["Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429441", "l": "SYK activation by SRC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1980044", "l": "NOTCH1 binds JAG2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34353", "l": "geranate + 2 H(+) + NADH => (2E)-geranial + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9710959", "l": "p-STAT1 dimer binds KPNA1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21043", "l": "CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] <=> CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114683", "l": "Phosphorylation of Platelet Sec-1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73960", "l": "2-methoxy-4-vinylphenol + H(+) + NADH => 4-ethyl-2-methoxyphenol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59795", "l": "H2O + NADP(+) + yersinopine <=> (2S)-2-amino-4-{[(1S)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58017", "l": "8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358518", "l": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51738", "l": "H(+) + N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine => L-lysyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832938", "l": "Expression of OTX2 in anterior neural plate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2022398", "l": "ACE:Zn2+ hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41216", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160932", "l": "SMURF1 binds phosphorylated PARD6A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31580", "l": "(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate => (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0055106", "l": "ubiquitin-protein transferase regulator activity", "d": ["Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33146", "l": "galactitol(in) <=> galactitol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73127", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine = 4',8-dihydroxy-7-methoxyflavone + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450292", "l": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.  (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52322", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + serotonin => O2 + reduced [NADPH--hemoprotein reductase] + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62142", "l": "dTDP + GDP => dTMP + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694441", "l": "CSNK1D phosphorylates SEC23 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9627350", "l": "SMAC (DIABLO) binds XIAP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2172666", "l": "RB1 binds condensin II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-164834", "l": "Enzyme-bound ATP is released (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9754180", "l": "APAP translocates from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8848053", "l": "ABCA5 transports CHOL from lysosomal lumen to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59936", "l": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2530501", "l": "FNTA:FNTB transfers FARN to GNGT1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33647", "l": "(9Z)-hexadecenoate + ATP + CoA = (9Z)-hexadecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2586748", "l": "GUCA binds Ca2+ to form GUCA:Ca2+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9734070", "l": "Anti-MET recombinant therapeutic antibodies bind MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39178", "l": "(3R)-hydroxyeicosanoyl-CoA <=> (2E)-eicosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64190", "l": "a fatty acid + L-tyrosine => an N-(fatty acyl)-L-tyrosine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32904", "l": "calciol + O2 + reduced [NADPH--hemoprotein reductase] => calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60707", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine <=> a 1-acyl-sn-glycero-2,3-cyclic phosphate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-750993", "l": "Inactive G alpha (q) reassociates with G beta:gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-917805", "l": "CYBRD1:Heme reduces Fe3+ to Fe2+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047222", "l": "mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77586", "l": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10557", "l": "D-glyceraldehyde 3-phosphate + L-arginine => H(+) + N(2)-(2-carboxyethyl)-L-arginine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483219", "l": "PC is exchanged with PI by PITPNB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28870", "l": "H(+)(in) + lactose(in) <=> H(+)(out) + lactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9858647", "l": "HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.98.-.-", "l": "\"Enzymes using H2 as reductant\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12575", "l": "(R)-1-aminopropan-2-ol + adenosylcob(III)yrate + ATP <=> adenosylcob(III)inamide + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14615", "l": "ADP + H(+) + phosphate + taurine(in) => ATP + H2O + taurine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034790", "l": "3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity", "d": ["Catalysis of the reaction: (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene = 3,4-dihydroxyfluorene + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373714", "l": "Cis-Heterodimerization of nephrin and KIRREL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2889036", "l": "Translation of OCT4 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23525", "l": "1-O-(trans-cinnamoyl)-beta-D-glucose + an alcohol => an alkyl cinnamate + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78748", "l": "an alpha-L-rhamnosyl-(1->4)-beta-D-glucuronide => a 4-deoxy-alpha-L-threo-hex-4-enopyranuronoside + L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624127", "l": "ARL6:GTP and the BBSome target cargo to the primary cilium (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807027", "l": "PTPN1 and PTPN2 dephosphorylate MET (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2130706", "l": "MHC class II antigen processing (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18332", "l": "(1S,3R,5S)-sabinol + NAD(+) <=> (1S,5S)-sabinone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20287", "l": "alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine => beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661116", "l": "KDM5A-D demethylate Me3K5-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043807", "l": "3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity", "d": ["Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1433374", "l": "Processing of SCF isoform 1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010331", "l": "gibberellin binding", "d": ["Binding to a gibberellin, a plant hormone that regulates aspects of plant growth."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23783", "l": "H2O + oxaloacetate + propanoyl-CoA <=> (2S,3S)-2-methylcitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061661", "l": "FAT10 ligase activity", "d": ["Catalysis of the transfer of FAT10 to a substrate protein via the reaction X-FAT10 + S = X + S-FAT10, where X is either an E2 or E3 enzyme, the X-FAT10 linkage is a thioester bond, and the S-FAT10 linkage is an isopeptide bond between the C-terminal glycine of FAT10 and the epsilon-amino group of lysine residues in the substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70782", "l": "D-glucose + NADP(+) <=> 6-dehydro-D-glucose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5617179", "l": "PRKACA phosphorylates TNNI3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30176", "l": "15-cis-phytoene + 2 plastoquinone-9 => 9,9',15-tri-cis-zeta-carotene + 2 plastoquinol-9", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50873", "l": "(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 => (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77424", "l": "cyclohexanecarbaldehyde + hydrogen cyanide => (2S)-2-cyclohexyl-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42917", "l": "adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine => 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76531", "l": "H(+) + N-acetyl-S-(2-succino)-L-cysteine + NADH + O2 = H2O + N-acetyl-L-cysteine + NAD(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54305", "l": "n 3'-phosphoadenylyl sulfate + dermatan 4'-sulfate => n adenosine 3',5'-bisphosphate + dermatan 4',6'-bissulfate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68748", "l": "alpha-D-glucose 1-phosphate + O-phospho-L-seryl-[protein] = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61791", "l": "ATP + holo-[peptidyl-carrier protein] + L-tryptophan <=> AMP + diphosphate + L-tryptophyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810899", "l": "TGM1 and involucrin bind the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008569", "l": "minus-end-directed microtubule motor activity", "d": ["A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19277", "l": "ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)", "d": [], "t": []}, {"i": "EC:6.1.1.26", "l": "\"pyrrolysine--tRNA(Pyl) ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-349603", "l": "Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202164", "l": "Translocation of PDK1 to Plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60935", "l": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 17-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28433", "l": "D-allose 6-phosphate <=> D-allulose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043870", "l": "N-acetyl-gamma-aminoadipyl-phosphate reductase activity", "d": ["Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42475", "l": "dibenzo-p-dioxin + NADH + O2 <=> 2,2',3-trihydroxydiphenyl ether + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450592", "l": "KSRP binds AU-rich element in 3' UTR of mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41641", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA => 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11985", "l": "AH2 + O2 + progesterone => A + H2O + testosterone acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43172", "l": "guanosine(1575) in yeast 18S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(1575) in yeast 18S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.309", "l": "\"18S rRNA (guanine(1575)-N(7))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102324", "l": "2-hydroxy-6-oxo-nona-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-nona-2,4-dienoate + H2O = butyrate + 2-oxopent-4-enoate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1112514", "l": "JAK activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110518", "l": "Activated DTOR also phosphorylates D4EBP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168887", "l": "Ferriheme is transferred from Albumin to Hemopexin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61694", "l": "AMP + L-threonyl-[peptidyl-carrier protein] => holo-[peptidyl-carrier protein] + L-threonyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684868", "l": "pro-SFTPC translocates from ER membrane to multivesicle body (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102379", "l": "steviolbioside glucosyltransferase activity (stevioside forming)", "d": ["Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = stevioside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-482772", "l": "Release of platelet cytosolic components (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201677", "l": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875623", "l": "SLC25A18,22 import L-Glu, H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234161", "l": "HIF-alpha translocates from cytosol to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30394", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamine <=> 2-oxoglutaramate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950415", "l": "Expression of heterogeneous nuclear ribonucleoprotein F (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848335", "l": "IL37 binds  IL18R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.45", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40614", "l": "H2O + trihexanoylglycerol <=> 2,3-dihexanoyl-sn-glycerol + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70481", "l": "TPI1 isomerizes GA3P to DHAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38707", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-sn-glycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-acetyl-3-(9Z)-octadecenoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019186", "l": "acyl-CoA N-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group from acyl-CoA to a nitrogen atom on an acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20076", "l": "D-allo-threonine <=> acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-507875", "l": "Aquaporins passively transport urea into cells (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-199169", "l": "MHC Class I interacts with CD160 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30235", "l": "H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374664", "l": "Phosphorylation and activation of Ezrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050357", "l": "tropinesterase activity", "d": ["Catalysis of the reaction: atropine + H2O = H+ + tropate + tropine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690911", "l": "ACO1:4Fe-4S isomerises CIT to ISCIT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70482", "l": "GAPDH tetramers reduce 1,3BPG to GA3P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173636", "l": "Formation of classic pathway C5 convertase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.53", "l": "\"Mn(2+)-dependent ADP-ribose/CDP-alcohol diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170686", "l": "Adenylate cyclase increases the GTPase activity of Gi alpha (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33236", "l": "2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 => 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433456", "l": "Recruitment of STATs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683792", "l": "p-T68-CHEK2 autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033886", "l": "cellulose-polysulfatase activity", "d": ["Catalysis of the hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373358", "l": "Receptor CXCR6 binds CXCL16 ligand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52775", "l": "7,8-dihydroneopterin 3'-triphosphate <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852809", "l": "CPN, CPB2 cleave C3a, C5a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9707523", "l": "Hemes bind to BACH1:MAFK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17053", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate", "d": [], "t": []}, {"i": "EC:2.2.1.2", "l": "\"transaldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687120", "l": "p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798317", "l": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14189", "l": "D-tryptophan + O2 = N-formyl-D-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139895", "l": "tBID activates BAK protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63062", "l": "2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+) => 5-methylorsellinate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61553", "l": "ent-7alpha-hydroxykaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => gibberellin A12 aldehyde + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951661", "l": "Transfer of NEDD8 to AcM-UBE2M (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0072374", "l": "carotene epsilon hydroxylase activity", "d": ["Catalysis of the reaction: a carotene + NADPH + O2 + H+ = a beta-ring hydroxylcarotene + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64315", "l": "2 chloride + 2 FADH2 + 2 O2 + sulochrin <=> dihydrogeodin + 2 FAD + H(+) + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983373", "l": "p-Y-STAT3 binds p-STAT5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "63.563042766192197", "identifiers": [{"i": "GO:0140677", "l": "molecular function activator activity", "d": ["A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48061", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032407", "l": "MutSalpha complex binding", "d": ["Binding to a MutSalpha mismatch repair complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952630", "l": "NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74329", "l": "O-propanoyl-(R)-carnitine(out) => O-propanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43420", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47656", "l": "acetyl-CoA + L-methionine sulfone = CoA + H(+) + N-acetyl-L-methionine sulfone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1470010", "l": "Dimerization of STATs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36041", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 H(+) + 8 NADH => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68766", "l": "8 AMP + 8 diphosphate + 8 H(+) + PF1022D + 4 S-adenosyl-L-homocysteine => (R)-3-phenyllactate + 3 (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047055", "l": "salutaridine synthase activity", "d": ["Catalysis of the reaction: (R)-reticuline + [reduced NADPH--hemoprotein reductase] + O2 -> salutaridine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030603", "l": "oxaloacetase activity", "d": ["Catalysis of the reaction: H2O + oxaloacetate = acetate + H+ + oxalate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114683", "l": "Phosphorylation of Platelet Sec-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14846", "l": "L-aspartate 4-semialdehyde + pyruvate => (S)-2,3-dihydrodipicolinate + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2581474", "l": "GRK1,4,7 phosphorylate MII to p-MII (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0000014", "l": "single-stranded DNA endodeoxyribonuclease activity", "d": ["Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782131", "l": "ERCC2-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22332", "l": "(3R)-citramalate = 2-methylmaleate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29126", "l": "nitrate(out) + ubiquinol-8(in) <=> H2O(out) + nitrite(out) + ubiquinone-8(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27383", "l": "(2R)-2-phosphoglycerate + phosphate => (2R)-2,3-bisphosphoglycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696670", "l": "CHD1L is recruited to GG-NER site (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69031", "l": "5beta-dihydrotestosterone + H(+) + NADPH <=> 5beta-androstane-3alpha,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73157", "l": "adenosine 3',5'-bisphosphate(in) + FMN(out) => adenosine 3',5'-bisphosphate(out) + FMN(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806957", "l": "MET receptor dimerizes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411351", "l": "TCF/LEF:CTNNB1 bind the AXIN2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6786097", "l": "p-Y705-STAT3, p-Y641-STAT6 dimerise (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9824894", "l": "TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0035014", "l": "phosphatidylinositol 3-kinase regulator activity", "d": ["Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74304", "l": "12alpha-hydroxy-3-oxochola-4-en-24-oate + NAD(+) => 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48766", "l": "3-acetyl-3-devinylchlorophyllide a + H(+) + NADH => 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40692", "l": "1-hexadecanoylglycerone 3-phosphate + pentadecan-1-ol => 1-O-pentadecylglycerone 3-phosphate + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36987", "l": "CMP + phosphate = alpha-D-ribose 1,5-bisphosphate + cytosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482887", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[3] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654409", "l": "Activated FGFR3 binds FRS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9707683", "l": "PGRMC2 binds Hemes (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163664", "l": "AMP binds to gamma subunit of AMP kinase heterotrimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807144", "l": "HTN1,HTN3 or HTN5 binds the bacterial anionic surface  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199219", "l": "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1638803", "l": "Phosphorylation of cohesin by PLK1 at centromeres (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18966", "l": "hydroxymethylbilane => H2O + uroporphyrinogen III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448673", "l": "Formation of caspase-1 p10/p20 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047941", "l": "glucuronolactone reductase activity", "d": ["Catalysis of the reaction: L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6813659", "l": "ELANE, CTSG or PRTN3 binds bacteria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418200", "l": "SRC-1 bound to ARRB2 is not activated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31422", "l": "(2Z,6E)-farnesyl diphosphate <=> (-)-beta-curcumene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11257", "l": "H2O + limonin + UDP-alpha-D-glucose => glucosyl-limonin + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-532630", "l": "p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64076", "l": "3,6,8,9-tetrahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 = 2,3,6,8,9-pentahydroxy-1-oxo-3-(2-oxopropyl)-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9834945", "l": "PINK1 phosphorylates Ub on MOM proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47157", "l": "7alpha,25-dihydroxycholesterol + NAD(+) => 7alpha,25-dihydroxy-4-cholesten-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39264", "l": "(2E,13Z)-docosadienoyl-CoA + H(+) + NADPH => (13Z)-docosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296045", "l": "Activation of Potassium transport channels (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58973", "l": "H2O + O2 + vanillin => H(+) + H2O2 + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-976734", "l": "Amyloid fibrils have additional components (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-508451", "l": "PTK2B is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52240", "l": "2 H2O + 2 Mn(2+) + O2 = 4 H(+) + 2 MnO2", "d": [], "t": []}, {"i": "EC:1.16.3.3", "l": "\"manganese oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5660663", "l": "Caspase-8 cleaves IL1B precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983144", "l": "Transport of Antigen peptide in to ER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5140741", "l": "WNT5A binds FZD and ROR receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0019534", "l": "toxin transmembrane transporter activity", "d": ["Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58948", "l": "4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine = 4-O-([3-N-acetyl-beta-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41615", "l": "alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O <=> D-ribose 2,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45117", "l": "(4R)-ipsdienol + NADP(+) => H(+) + ipsdienone + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56553", "l": "ATP + L-threonyl-[rhodopsin] => ADP + H(+) + O-phospho-L-threonyl-[rhodopsin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654054", "l": "DRD2 antagonist drugs bind to DRD2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66009", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] => [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31391", "l": "15-cis-4,4'-diapophytoene + 4 FAD + 4 H(+) = all-trans-4,4'-diapolycopene + 4 FADH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10806", "l": "(R)-allantoin => (S)-allantoin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20622", "l": "ATP + H2O + Zn(2+)(in) => ADP + H(+) + phosphate + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18195", "l": "(S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate => H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56405", "l": "[(3R)-hydroxybutanoate](n) + H2O => (3R)-hydroxybutanoate pentamer + [(3R)-hydroxybutanoate](n-5) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74944", "l": "2-oxoglutarate + a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + O2 => a (3R)-3-isocyanyl-fatty acid + 2 CO2 + 2 H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23026", "l": "[(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate => [(1->4)-beta-D-glucosyl](n) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0038132", "l": "neuregulin binding", "d": ["Binding to a neuregulin, a member of the EGF family of growth factors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004582", "l": "dolichyl-phosphate beta-D-mannosyltransferase activity", "d": ["Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.-", "l": "\"Site specific endodeoxyribonucleases: cleavage is sequence specific\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44433", "l": "2 a 1-acylglycerol => a 1,2-diacylglycerol + glycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.2.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40097", "l": "2 H(+) + hexacosanedioate + NADH => 26-oxohexacosanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60454", "l": "acetaldehyde + H(+) + sulfite => 2-hydroxyethane-1-sulfonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034899", "l": "trimethylamine monooxygenase activity", "d": ["Catalysis of the reaction: N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5622134", "l": "CRABP1 binds atRA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51752", "l": "a 2-acylphloroglucinol + dimethylallyl diphosphate = a 2-acyl-4-prenylphloroglucinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9606887", "l": "p-CD19:VAV binds PI3K and GRB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656523", "l": "An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.36", "l": "\"pancreatic elastase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75642", "l": "(8E,10R,12Z)-10-hydroperoxyoctadeca-8,12-dienoate <=> (12S,13R)-epoxy-(10R)-hydroxy-(8E)-octadecenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4839635", "l": "CTNNB1 S37 mutants aren't phosphorylated by GSK3beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985981", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4754181", "l": "KDM5A-D demethylate Me2K5-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30213", "l": "2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide => 2 Fe(III)-[cytochrome c] + H2O + nitrous oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614031", "l": "Class IV antihypertensives bind LTCC multimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46725", "l": "(2S)-2-methyltetradecanoyl-CoA => (2R)-2-methyltetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63205", "l": "H2O + octadecanoyl-[ACP] => H(+) + holo-[ACP] + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74482", "l": "(-)-cyclopeptine + 2-oxoglutarate + O2 <=> (Z)-dehydrocyclopeptine + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15077", "l": "H(+) + N-[(R)-pantothenoyl]-L-cysteine = (R)-pantetheine + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.30", "l": "\"pantothenoylcysteine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948775", "l": "MKRN1 polyubiquitinates PTEN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37126", "l": "sphing-4-enine + tetracosenoyl-CoA <=> CoA + H(+) + N-(tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0016175", "l": "superoxide-generating NAD(P)H oxidase activity", "d": ["Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689085", "l": "ATXN3 binds polyUb-PARK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52434", "l": "2 NH4(+) + pyruvate => (R)-2,3-diaminopropanoate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75036", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate => 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69902", "l": "2 Na(+)(out) + thymidine(out) <=> 2 Na(+)(in) + thymidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.3.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201521", "l": "ALK autophosphorylation  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29982", "l": "2'-deoxyadenosine(in) + H(+)(in) <=> 2'-deoxyadenosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9008054", "l": "IL1F10 binds IL1RAPL1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31661", "l": "5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine => beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GlcpNAc + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66774", "l": "ADP + H(+) + phosphate + uroporphyrin I(out) => ATP + H2O + uroporphyrin I(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77312", "l": "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49902", "l": "H2O2 + phenazine-1,6-dicarboxylate => 5,10-dihydrophenazine-1,6-dicarboxylate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78588", "l": "eicosanoyl-CoA + O2 => (2E)-eicosenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6784393", "l": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990275", "l": "preribosome binding", "d": ["Binding to a preribosome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3000120", "l": "CBLIF binds RCbl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35317", "l": "3-oxooctadecanoyl-CoA + CO2 + CoA => H(+) + hexadecanoyl-CoA + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69622", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-{beta-D-GlcNAc-(1->6)}-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417820", "l": "P2Y9 receptor can bind to LPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6786190", "l": "CMBL hydrolyses OM to OLMS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11312", "l": "atrazine + H2O = chloride + H(+) + hydroxyatrazine", "d": [], "t": []}, {"i": "EC:3.8.1.8", "l": "\"atrazine chlorohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65768", "l": "a 1,1-dimethyl-3-phenylurea + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = a 1-methyl-3-phenylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.38", "l": "\"N,N-dimethyl phenylurea N-demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008841", "l": "dihydrofolate synthase activity", "d": ["Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-426520", "l": "Endonucleolytic RISC hydrolyzes target RNAs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140942", "l": "histone H3K9 dimethyltransferase activity", "d": ["Catalysis of the reaction: L-lysyl9-[histone H3] + 2 S-adenosyl-L-methionine = 2 H+ + N6,N6-dimethyl-L-lysyl9-[histone H3] + 2 S-adenosyl-L-homocysteine. This reaction is the successive addition of two methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018815", "l": "RHOT1 binds effectors at the mitochondrial outer membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090585", "l": "protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + L-ascorbate(out) = protein cysteine + L-ascorbate-6-phosphate(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35806", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O <=> 7,8-dihydroneopterin 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928642", "l": "TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31507", "l": "aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate", "d": [], "t": []}, {"i": "EC:4.3.3.6", "l": "\"pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953398", "l": "PIR oxygenates quercetin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9853878", "l": "FIGNL1 binds DMC1, RAD51 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24208", "l": "1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655170", "l": "RCHY1 monoubiquitinates POLH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24840", "l": "5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine", "d": [], "t": []}, {"i": "EC:4.1.99.17", "l": "\"phosphomethylpyrimidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76636", "l": "n H(+)(out) + Mn(2+)(in) => n H(+)(in) + Mn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40895", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z)-octadecenoate + H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693373", "l": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49630", "l": "3,5-dimethylorsellinate + 3 CO2 + 4 CoA + 2 S-adenosyl-L-homocysteine => acetyl-CoA + 3 malonyl-CoA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193702", "l": "Part of the ICD migrates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22457", "l": "creatine + H2O => sarcosine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77385", "l": "CO2 + heptane => H(+) + hnu + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551724", "l": "PIAS4 SUMOylates HERC2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379464", "l": "COMT transfers Met to DOPAC to form HVA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48843", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 <=> (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.186", "l": "\"glycogenin glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682044", "l": "KAT5 acetylates ATM at DNA DSBs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15209", "l": "(2R,3R)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55353", "l": "all-trans-retinol => 13-cis-retinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26292", "l": "2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine <=> 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35229", "l": "H(+)(in) + rifampicin(out) => H(+)(out) + rifampicin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71604", "l": "2-oxoglutarate(out) + oxaloacetate(in) => 2-oxoglutarate(in) + oxaloacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169398", "l": "ISGylation of host protein filamin B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8943279", "l": "GGT dimers hydrolyse GSH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67426", "l": "a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+) => a glycerophospholipid + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27362", "l": "chloride + S-adenosyl-L-methionine => chloromethane + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47855", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + H2O <=> a neolactoside nLc4Cer(d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159567", "l": "ACSM2B-like proteins transform ST to ST-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65062", "l": "7-oxotaurolithocholate + H(+) + NADPH => NADP(+) + taurochenodeoxycholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020264", "l": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209200", "l": "HEP is phosphorylated and activated by Phospho TAK1:TAB2 kinase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.56", "l": "\"lytic cellulose monooxygenase (C4-dehydrogenating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5246478", "l": "APOM binds retinoids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71635", "l": "phosphate(in) + 2 thiosulfate(out) = phosphate(out) + 2 thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25613", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = terpentedienyl diphosphate", "d": [], "t": []}, {"i": "EC:5.5.1.15", "l": "\"terpentedienyl-diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30155", "l": "FADH2 + 2 Fe(3+) = FAD + 2 Fe(2+) + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683714", "l": "ABCA3 transports PC, PG from ER membrane to lamellar body (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20108", "l": "ADP + beta-D-fructose 6-phosphate <=> AMP + beta-D-fructose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876366", "l": "LDL translocates from endosome lumen to lysosome lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662613", "l": "MT3 exchanges zinc for copper (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41260", "l": "L-tryptophan => (E)-3-(indol-3-yl)acrylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73381", "l": "(R)-lipoate(in) + 2 Na(+)(in) => (R)-lipoate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11688", "l": "ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)", "d": [], "t": []}, {"i": "EC:6.1.1.4", "l": "\"leucine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70664", "l": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60773", "l": "2 2-oxoglutarate + gibberellin A12 + H(+) + 3 O2 => 3 CO2 + gibberellin A9 + 2 H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10389", "l": "GTP + oxaloacetate => CO2 + GDP + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.674113164858127", "identifiers": [{"i": "GO:0033558", "l": "protein lysine deacetylase activity", "d": ["Catalysis of the reaction: H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.19.12", "l": "\"ubiquitinyl hydrolase 1\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43284", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42862", "l": "1,2-dioctanoyl-sn-glycerol + phosphate => 1,2-dioctanoyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36865", "l": "(9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O => (9Z)-octadecenoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701507", "l": "PTPN6 dephosphorylates JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68789", "l": "(2Z,6Z)-farnesyl diphosphate => (Z)-gamma-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798749", "l": "Exocytosis of specific granule lumen proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013159", "l": "CDC42 GEFs activate CDC42 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9707690", "l": "BACH1 binds MAFK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0016174", "l": "NAD(P)H oxidase H2O2-forming activity", "d": ["Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.2.9", "l": "\"microsomal epoxide hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6805638", "l": "KAT6A acetylates TP53 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5340320", "l": "GLTP transports GSL from plasma membrane to ER membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174157", "l": "Degradation of multiubiquitinated Cyclin B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103060", "l": "kaempferol 3-rhamnoside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: kaempferol-3-rhamnoside + UDP-L-rhamnose = kaempferol-3-rhamnoside-7-rhamnoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28895", "l": "cadaverine(in) + L-lysine(out) = cadaverine(out) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193821", "l": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617829", "l": "Assembly of IFT A complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71008", "l": "L-phenylalanine(out) + L-tryptophan(in) => L-phenylalanine(in) + L-tryptophan(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928615", "l": "EFNBs bind SFKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444100", "l": "PROT mediates L-proline uptake (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31615", "l": "dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose + 2 S-adenosyl-L-methionine = dTDP-D-ravidosamine + 2 H(+) + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.236", "l": "\"dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9614273", "l": "ADGRG heterodimer translocates to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373720", "l": "FADK1 interaction with DCC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61163", "l": "quercetin + UDP-beta-L-rhamnose <=> H(+) + quercitrin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9014433", "l": "RHOG GEFs activate RHOG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38778", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27571", "l": "ATP + D-glycero-alpha-D-manno-heptose 7-phosphate => ADP + D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60657", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12639", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP => (5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9009227", "l": "IL20 binds to IL22RA1:JAK1:IL20RB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114548", "l": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008803", "l": "bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity", "d": ["Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53172", "l": "1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65241", "l": "(11Z)-octadecenoyl-CoA + H2O => (11Z)-octadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.57", "l": "\"aromatic-amino-acid transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1362408", "l": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43812", "l": "1,2-dioctadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15906", "l": "3-hydroxycyclohexanone + A => AH2 + cyclohexane-1,3-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1592387", "l": "Fibulin binds elastic fibres (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-917693", "l": "ESCRT Disassembly (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76393", "l": "glycylglycylglycine(in) + n H(+)(in) => glycylglycylglycine(out) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935980", "l": "RUNX1 binds the OCLN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-378513", "l": "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57163", "l": "2-oxoglutarate + L-arginyl-[ribosomal protein eS6] + O2 <=> (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6811414", "l": "GBF1 stimulates nucleotide exchange on ARF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103042", "l": "4-hydroxy-L-threonine aldolase activity", "d": ["Catalysis of the reaction: 4-hydroxy-L-threonine = glycolaldehyde + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1454916", "l": "The ABCC family mediates organic anion transport (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.21", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800797", "l": "The PIDDosome activates CASP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8944218", "l": "Association of procollagen type VIII (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5682858", "l": "RNF8 and RNF168 ubiquitinate H2AFX (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61480", "l": "a sphingoid base + a very long-chain fatty acyl-CoA = an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.1.297", "l": "\"very-long-chain ceramide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64465", "l": "L-tyrosyl-[protein] + 2 O2 => H(+) + H2O2 + L-topaquinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9717834", "l": "GGPS1 hexamer transfers IPPP to DMAPP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034851", "l": "2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + CoASH = pivalyl-CoA + propanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987080", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5660660", "l": "p300 acetylates RELA subunit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428750", "l": "Gq activation by TP receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54570", "l": "a pseudouridine in rRNA => a uridine in rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34373", "l": "(indol-3-yl)acetate + NH4(+) => H2O + indole-3-acetamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71260", "l": "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2213201", "l": "Formation of collagen fibres (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19199", "l": "adenosine 5'-phosphoramidate + 2 H(+) + sulfate => adenosine 5'-phosphosulfate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33195", "l": "a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74438", "l": "a 1-acyl-sn-glycero-3-phosphocholine(out) + H(+)(out) <=> a 1-acyl-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855211", "l": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9695949", "l": "SPHK2 phosphorylates sphingoid (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69116", "l": "Formation of Okazaki fragments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39282", "l": "ATP + dodecanoate(out) + H2O <=> ADP + dodecanoate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432909", "l": "Interaction of Plectin with Integrin beta 4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65652", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontanoyl)-sphing-4-enine = a diacylglycerol + N-(32-(9Z,12Z-octadecadienoyloxy)-dotricontanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-433786", "l": "Phosphorylation of IRF3 by TBK1 complexed with activated TLR3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862184", "l": "USP48 cleaves polyubiquitin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50849", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 => (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19956", "l": "a 2-oxocarboxylate + L-alanine <=> an L-alpha-amino acid + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50429", "l": "methanethiol + S-adenosyl-L-methionine => dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35599", "l": "NADP(+) + propane-1,3-diol = 3-hydroxypropanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63161", "l": "H2O + N-(15Z-tetracosenoyl)-taurine => (15Z)-tetracosenoate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14867", "l": "H(+) + N-methyltyramine + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-189222", "l": "SLC2A5 transports fructose from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62003", "l": "3 A + protoporphyrinogen IX <=> 3 AH2 + protoporphyrin IX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9693324", "l": "Disulfiram covalently modifies Cys191 in GSDMD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27869", "l": "(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O <=> (R)-glycerate + alpha-D-mannose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028692", "l": "Cleavage of p-STK4 (p-MST1) by caspase 3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9702638", "l": "tandutinib-resistant FLT3 mutants don't bind tandutinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15938", "l": "a primary alcohol + NADP(+) => an aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60258", "l": "AH2 + formaldehyde + L-lysyl(4)-[histone H3] => A + H2O + N(6)-methyl-L-lysyl(4)-[histone H3]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52116", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42261", "l": "H(+) + heptanoyl-CoA + malonyl-[ACP] => 3-oxononanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855259", "l": "atROL binds RBP1 (parenchymal cell) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78590", "l": "eicosanoyl-CoA + O2 <=> (2E)-eicosenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46450", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr) => 2 L-tyrosyl-tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40887", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + octadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54500", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = beta-geranylfarnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37317", "l": "glycine + L-glutamine => glycyl-L-glutamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686015", "l": "Nsp3, nsp4, and nsp6 produce replicative organelles (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74725", "l": "3',4'-O-dimethylquercetin + 2 H(+) + S-adenosyl-L-homocysteine => isorhamnetin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49763", "l": "EDTA + FMNH2 + O2 <=> ethylenediaminetriacetate + FMN + glyoxylate + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066780", "l": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803753", "l": "NAAA hydrolyses NAEs to FAs and ethanolamine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035374", "l": "chondroitin sulfate binding", "d": ["Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61281", "l": "4-aminobutanoate + H2O + O2 => H2O2 + NH4(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9656244", "l": "DRD2 binds DA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205118", "l": "TRAF6 polyubiquitinates NRIF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690870", "l": "OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22173", "l": "beta-D-fructose 6-phosphate + UDP-alpha-D-glucose => H(+) + sucrose 6(F)-phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52165", "l": "O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] => (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73605", "l": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25788", "l": "4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde", "d": [], "t": []}, {"i": "EC:4.1.2.52", "l": "\"4-hydroxy-2-oxoheptanedioate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4827382", "l": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77643", "l": "adenosine 2',5'-bisphosphate + H2O = AMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54666", "l": "pre-alpha-onocerin => (3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109860", "l": "MAP2K1 phosphorylates MAPK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58892", "l": "3'-phosphoadenylyl sulfate + omega-hydroxy-beta-dihydromenaquinone-9 = adenosine 3',5'-bisphosphate + H(+) + omega-sulfo-beta-dihydromenaquinone-9", "d": [], "t": []}, {"i": "EC:2.8.2.40", "l": "\"omega-hydroxy-beta-dihydromenaquinone-9 sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701064", "l": "TRPV1 binds TRPV1 agonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39324", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15134", "l": "H2O + L-glutamate + NAD(+) => 2-oxoglutarate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669158", "l": "NF2 binds PAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55704", "l": "glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide", "d": [], "t": []}, {"i": "EC:2.4.2.59", "l": "\"sulfide-dependent adenosine diphosphate thiazole synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73596", "l": "CTP(out) + dUMP(in) => CTP(in) + dUMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53670", "l": "(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62739", "l": "1-hydroxy-3-(indol-3-ylmethyl)-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + dimethylallyl diphosphate <=> 1-hydroxy-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6H,7H,8H-5lambda(5)-pyrrolo[1,2-a]pyrazine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051062", "l": "UDP reductase activity", "d": ["Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196773", "l": "COASY phosphorylates DP-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18513", "l": "D-mannitol + O2 = D-mannose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9726949", "l": "PTGIR binds PTGIR agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9839113", "l": "AFG3L2 degrades mitochondrial inner membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1112666", "l": "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-451942", "l": "Within the IL-2R complex JAK3 phosphorylates JAK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70432", "l": "2 H(+)(out) + Li(+)(in) => 2 H(+)(in) + Li(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17134", "l": "ATP + L-seryl-[tyrosine-3-monooxygenase] => ADP + H(+) + O-phospho-L-seryl-[tyrosine-3-monooxygenase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39268", "l": "(15Z)-3-oxotetracosenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z)-tetracosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876993", "l": "CBLL1 binds SRC-phosphorylated CDH1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877348", "l": "RUNX1, FOXP3 and NFATC2 bind the IL2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187545", "l": "Association of Cks1 with SCF(Skp2) complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654569", "l": "Activated FGFR1 binds FRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23606", "l": "H2O + kievitone => kievitone hydrate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018798", "l": "RHOV binds GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73596", "l": "dCMP + H2O => dUMP + NH4+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72697", "l": "Start codon recognition (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40130", "l": "an omega-oxo fatty acid + O2 + reduced [NADPH--hemoprotein reductase] <=> a dicarboxylate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28618", "l": "2-methylbutyronitrile + H(+) + NADPH + O2 = 2-hydroxy-2-methylbutanenitrile + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61385", "l": "5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O => 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29084", "l": "(S)-malate + ubiquinone-8 => oxaloacetate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684081", "l": "MRN complex binds CDK2 and RBBP8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551570", "l": "VANGL2 is phosphorylated in response to WNT5A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37356", "l": "H2O + uridine 2'-phosphate => phosphate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20196", "l": "(R)-mevalonate + NADP(+) <=> (R)-mevaldate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53642", "l": "(-)-alpha-amorphene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37270", "l": "H2O + L-alanyl-L-aspartate <=> L-alanine + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5627071", "l": "RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40747", "l": "2-oxoglutarate + L-lysine + O2 = (3S)-3-hydroxy-L-lysine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694462", "l": "ABHD6,12 hydrolyse 3AG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19392", "l": "(E)-ferulate + ATP + CoA <=> (E)-feruloyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54564", "l": "a 5'-end ribonucleotide-tRNA(His) + ATP + GTP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.7.79", "l": "\"tRNA(His) guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67954", "l": "an omega-hydroxy-very-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78650", "l": "ATP + S-sulfanyl-L-cysteine + tRNA(Cys) <=> (S)-sulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322422", "l": "Beta-catenin recruits SMARCA4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64012", "l": "acetyl-CoA + AH2 + 3 malonyl-CoA + 3 S-adenosyl-L-methionine = A + 3 CO2 + 4 CoA + fumigermin + H2O + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40408", "l": "1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP => 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.19.33", "l": "\"Delta(12) acyl-lipid conjugase (11E,13E-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35250", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O <=> ADP + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5695957", "l": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27773", "l": "3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> 2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801328", "l": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21949", "l": "formamide + H2O => formate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102109", "l": "tricaffeoyl spermidine O-methyltransferase activity", "d": ["Catalysis of the reaction: tricaffeoyl spermidine + 3 S-adenosyl-L-methionine = 3 H+ + triferuloyl spermidine + 3 S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19455", "l": "L-glutamate + pyruvate => 2-oxoglutarate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791035", "l": "Release of NS1 homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203700", "l": "eNOS translocation from Golgi to Caveolae (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195664", "l": "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30013", "l": "ADP + beta-D-galactose(in) + H(+) + phosphate => ATP + beta-D-galactose(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2399981", "l": "AKT1 E17K mutant phosphorylates MDM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618110", "l": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183072", "l": "EGFR non-clathrin mediated endocytosis (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036082", "l": "extracellular phenylacetaldehyde-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5358592", "l": "DNA ligase I ligates single stranded nick in double stranded DNA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817512", "l": "UNG (UNG2) and base excision repair remove uridine and 5-methylcytidine from chromatin containing histone H3.3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8874685", "l": "CBL binds MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615490", "l": "p-S133-CREB1 binds MIR132 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9620515", "l": "KAT2B,EP300 acetylate FOXO3 under oxidative stress (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43211", "l": "5-(carboxymethyl)uridine(34) in tRNA + S-adenosyl-L-methionine <=> 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48486", "l": "an aliphatic alcohol + H(+) + propanoate => a propanoate ester + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-727759", "l": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9835009", "l": "PRKN binds p-S-Ub:MOM proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77367", "l": "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + CMP-N-acetyl-beta-neuraminate = [N-acetyl-alpha-D-neuraminosyl-(2->8)](n+1) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205681", "l": "Pink1 is cleaved on healthy mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73826", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate <=> an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2509838", "l": "ITPA hydrolyses dITP to dIMP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-378978", "l": "CGA and CGB3 bind to form Human chorionic gonadotropin (hCG) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74606", "l": "CMP(out) + UDP-alpha-D-galactose(in) <=> CMP(in) + UDP-alpha-D-galactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008764", "l": "UDP-N-acetylmuramoylalanine-D-glutamate ligase activity", "d": ["Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77978", "l": "dimethylallyl diphosphate + 5 isopentenyl diphosphate <=> all-trans-hexaprenyl diphosphate + 5 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34787", "l": "a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6785213", "l": "LIPC dimer binds heparin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6788622", "l": "p-Y-STATs dimerize (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74021", "l": "glycine(in) + L-alanine(out) => glycine(out) + L-alanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6781833", "l": "ERCC8 (CSA) binds stalled RNA Pol II (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213210", "l": "Collagen IX is cross-linked to the surface of collagen type II fibrils (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61057", "l": "(-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + lochnericine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12844", "l": "pyridoxamine + pyruvate <=> L-alanine + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018507", "l": "cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity", "d": ["Catalysis of the reaction: (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD+ = H+ + NADH + phenanthrene-3,4-diol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70524", "l": "PXLP-K314-GPT transaminates PYR to form L-Ala (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635865", "l": "SMURF1/2 dissociates from ub-PTCH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55007", "l": "1-hydroxylimonen-2-one + NADPH + O2 <=> 3-isopropenyl-6-oxoheptanoate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37609", "l": "1-(9Z)-octadecenoyl-2-(6Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (6Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72304", "l": "L-glutamate(in) + L-thyroxine(out) => L-glutamate(out) + L-thyroxine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193997", "l": "CYP11B1 oxidises 11DCORT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46287", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55590", "l": "a 1,2-diacyl-sn-glycerol + an inositol-1-phosphoceramide => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74906", "l": "(2E)-2-butenoate + ATP + H(+) <=> (2E)-but-2-enoyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-877361", "l": "Pyrin binds ASC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53600", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044584", "l": "cellodextrin binding", "d": ["Binding to a cellodextrin, a glucose polymer of 2 or more glucose monomers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177284", "l": "PKA phosphorylates PDE4B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202704", "l": "Integrin alphaXbeta2 binds JAM3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30958", "l": "9,9'-di-cis-zeta-carotene + 2 a quinone <=> 7,7',9,9'-tetra-cis-lycopene + 2 a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8873929", "l": "Casein kinase II phosphorylates STARD10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955289", "l": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49505", "l": "phosphinomethylmalate => phosphinomethylisomalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389491", "l": "Two NPFF receptors can bind neuropeptide FF (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13753", "l": "2 L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + L-glutamine + NADH", "d": [], "t": []}, {"i": "EC:1.4.1.14", "l": "\"glutamate synthase (NADH)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43479", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 <=> 10-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27455", "l": "3-iodo-L-tyrosine + NADPH => iodide + L-tyrosine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39348", "l": "(2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H(+) + NADPH => (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66665", "l": "ATP + coproporphyrin III(in) + H2O => ADP + coproporphyrin III(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9692880", "l": "HRH3 binds Hist (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9854961", "l": "SDHAF4 binds to FAD-SDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.144", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64112", "l": "an N-acyl-L-phenylalanine + H2O = a fatty acid + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-517444", "l": "TAT aminates HPP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19787", "l": "clavaminate + CO2 + H2O + succinate => 2-oxoglutarate + dihydroclavaminate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803789", "l": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47513", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => isocholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46593", "l": "alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198613", "l": "AKT phosphorylates p21Cip1 and p27Kip1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5683593", "l": "ATG7:ATG3:LC3 dissociates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676591", "l": "2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75342", "l": "chloride(out) + nitrate(in) <=> chloride(in) + nitrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16237", "l": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)", "d": [], "t": []}, {"i": "EC:5.2.1.8", "l": "\"peptidylprolyl isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65778", "l": "3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => chlorotoluron + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985900", "l": "p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158893", "l": "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9009817", "l": "Acitretin binds to RAR:RXR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-508040", "l": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55801", "l": "an N-acyleicosasphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an N-acyleicosasphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11311", "l": "acetyl-CoA + ATP + hydrogencarbonate <=> ADP + H(+) + malonyl-CoA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20416", "l": "glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine <=> glucuronoxylan 4-O-methyl-D-glucuronate + n H(+) + n S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675417", "l": "PEBP1 binds activated RAF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1483121", "l": "PA is converted to CDP-DAG by CDS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20200", "l": "[heparosan-N-sulfate](n) <=> [heparan-N-sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35590", "l": "FMN + H2O <=> phosphate + riboflavin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9856871", "l": "MDH1 reduces OA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15519", "l": "H(+) + N-sulfo-D-glucosamine + sulfate => H2O + N(2),6-disulfo-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56399", "l": "[(3R)-hydroxybutanoate](n) + H2O <=> (3R)-hydroxybutanoate trimer + [(3R)-hydroxybutanoate](n-3) + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9690534", "l": "NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001635", "l": "calcitonin gene-related peptide receptor activity", "d": ["Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9824979", "l": "XPO1 binds p-S69,73 MITF-M (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30217", "l": "a menaquinone + H2O + nitrous oxide => a menaquinol + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688797", "l": "ATXN3 family cleave Ub chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53096", "l": "4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine = 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17246", "l": "3-hydroxyanthranilate + O2 => 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654634", "l": "Activated FGFR3 phosphorylates SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35234", "l": "rifampicin(in) <=> rifampicin(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663265", "l": "NR1D1 (REV-ERBA) binds heme, the NR1D1 gene, and recruits corepressors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190388", "l": "Autocatalytic phosphorylation of FGFR3c (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39797", "l": "7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate => 7beta-hydroxycholesterol(in) + ATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14286", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose => 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935785", "l": "RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53599", "l": "1-octadecanoyl-sn-glycero-3-phosphate + H2O <=> 1-octadecanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56587", "l": "1,2-epoxypropane + H2O <=> propane-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158251", "l": "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22534", "l": "(3S)-hydroxyoctanedioyl-CoA => (2E)-octenedioyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5626962", "l": "GNB2L1 binds IKKA:IKKB:NEMO (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65498", "l": "3beta,20alpha-dihydroxy-5beta-pregnane + NADP(+) => 3beta-hydroxy-5beta-pregnane-20-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59140", "l": "ATP + citrate + N(5)-[(S)-citryl]-D-ornithine = AMP + diphosphate + H(+) + staphyloferrin A", "d": [], "t": []}, {"i": "EC:6.3.2.57", "l": "\"staphyloferrin A synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.10.1", "l": "\"receptor protein-tyrosine kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75010", "l": "Phosphorylation of Cdc25C at Ser 216 by Chk1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70494", "l": "Enolase dimers (ENO1,2,3) convert PEP to 2PG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004051", "l": "arachidonate 5-lipoxygenase activity", "d": ["Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0016434", "l": "rRNA (cytosine) methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71285", "l": "chloride(in) + L-glutamine(in) + 2 Na(+)(in) => chloride(out) + L-glutamine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9859104", "l": "MITF-M-dependent ASAH1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444160", "l": "VMAT1/2 can mediate the transport of biogenic amines (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382057", "l": "Release of novel PDGFs as latent factors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20063", "l": "a ribonucleoside 5'-diphosphate + dCMP + H(+) => 2'-deoxycytidine + a ribonucleoside 5'-triphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53350", "l": "H(+) + NADH + uridine(20a) in tRNA => 5,6-dihydrouridine(20a) in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45685", "l": "N-dodecanoyl-sphing-4-enine-1-phosphate(in) => N-dodecanoyl-sphing-4-enine-1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22180", "l": "(S)-norreticuline + S-adenosyl-L-methionine = (S)-norcodamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042328", "l": "heparan sulfate N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41200", "l": "1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654677", "l": "CBL ubiquitinates FRS2 and FGFR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.288", "l": "\"2-O-sulfo trehalose long-chain-acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22523", "l": "all-trans-retinal + H2O + O2 <=> all-trans-retinoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37817", "l": "2-methyl-4-chlorophenol + CO2 + pyruvate + succinate => (R)-2-(4-chloro-2-methylphenoxy)propanoate + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5662466", "l": "XYLB phosphorylates D-xylulose (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57850", "l": "CO2 + fraxetin + succinate => 2-oxoglutarate + O2 + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12309", "l": "(S)-2-amino-6-oxohexanoate + H2O + NAD(+) => 2 H(+) + L-2-aminoadipate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24278", "l": "acetyl phosphate + phosphate => acetate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78366", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine <=> 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-O-acyl-N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692232", "l": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174374", "l": "MTR transfers CH3 from MeCbl to HCYS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710106", "l": "ELANE cleaves GSDMD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64864", "l": "ITP + oxaloacetate = CO2 + IDP + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39355", "l": "(2E,11Z,14Z,17Z,20Z)-hexacosapentaenoyl-CoA + H(+) + NADPH = (11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20759", "l": "(E)-caffeoyl-CoA + D-threo-isocitrate <=> 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.5", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.8.4.11", "l": "\"peptide-methionine (S)-S-oxide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004474", "l": "malate synthase activity", "d": ["Catalysis of the reaction: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727198", "l": "ATP4A:ATP4B exchanges K+ for H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33228", "l": "(E)-4-coumarate + H(+) => 4-hydroxystyrene + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-200423", "l": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59299", "l": "an N-acylglycine + 2 L-ascorbate + O2 <=> an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675656", "l": "EDA:EDAR binds EDARADD (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38963", "l": "ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9825783", "l": "p-S207 KARS1 dimer translocates to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76930", "l": "3-aminopentane + H2O + NADP(+) <=> H(+) + NADPH + NH4(+) + pentan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43751", "l": "ATP + CoA + hexacosanoate <=> AMP + diphosphate + hexacosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46356", "l": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2468293", "l": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35053", "l": "N,N'-diacetylchitobiose(in) => N,N'-diacetylchitobiose(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004317", "l": "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity", "d": ["Catalysis of the reaction: (3R)-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-176116", "l": "Recruitment and activation of Chk1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130706", "l": "MHC class II antigen processing (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78424", "l": "D-glucosamine(out) => D-glucosamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77319", "l": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5672948", "l": "MARK3 phosphorylates KSR1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21711", "l": "H2O + S-adenosyl-L-homocysteine <=> adenosine + L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69979", "l": "(22R,23R)-22,23-dihydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,23R)-22,23-dihydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59200", "l": "ATP + docosanoate + H(+) = diphosphate + docosanoyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15521", "l": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]", "d": [], "t": []}, {"i": "EC:2.3.1.97", "l": "\"glycylpeptide N-tetradecanoyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10903", "l": "an aromatic L-alpha-amino acid + glyoxylate <=> an aromatic oxo-acid + glycine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61989", "l": "cytidine(72) in tRNA + S-adenosyl-L-methionine => 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9718360", "l": "GNRHR binds GNRHR peptide agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71035", "l": "L-phenylalanine(out) + L-serine(in) = L-phenylalanine(in) + L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45647", "l": "H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine <=> H(+) + N-hexadecanoylsphing-4-enine + phosphocholine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705458", "l": "p-Y-STAT1,3,5 dimer enhances expression of SOCS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56677", "l": "dihydroferuloyl-CoA + NADP(+) => (E)-feruloyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420975", "l": "Ca impermeable AMPA receptor ligand binding (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53187", "l": "1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O <=> 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52335", "l": "2 N(omega)-hydroxy-L-arginine + 2 O2 + reduced [flavodoxin] <=> 3 H(+) + 2 H2O + 2 L-citrulline + 2 nitric oxide + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46847", "l": "4alpha-formyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987039", "l": "JAK1 binds IL20RA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31078", "l": "(3S)-3-hydroxydodecanoyl-CoA <=> (2E)-dodecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9668405", "l": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977348", "l": "PHGDH tetramer dehydrogenates 3PG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47937", "l": "4-hydroxybenzaldehyde + H2O + NADP(+) => 4-hydroxybenzoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2422927", "l": "MAPK3-3 or MAPK1 phosphorylate GORASP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873921", "l": "Binding of STAT1 to p-IFNGR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192033", "l": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60676", "l": "(S)-(-)-citronellol + NAD(+) = (S)-(-)-citronellal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43717", "l": "[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate => [glutamine synthetase]-L-tyrosine + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54757", "l": "deamido-NAD(+) + hydrogencarbonate => AMP + 2 H(+) + pyridinium-3,5-dicarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70715", "l": "glycine(in) = glycine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38706", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869506", "l": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24849", "l": "3-dehydroshikimate => 3,4-dihydroxybenzoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64382", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2 => 3 A + phytyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24990", "l": "calcitroate + H2O + 2 oxidized [adrenodoxin] => (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070984", "l": "SET domain binding", "d": ["Binding to a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1362270", "l": "Phosphorylation of LIN52 component of MuvB by DYRK1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64911", "l": "CTP + 2 H2O <=> CMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380311", "l": "Recruitment of Plk1 to centrosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47709", "l": "ADP + alpha-D-glucose 1-phosphate + H(+) => ADP-alpha-D-glucose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28464", "l": "pyridoxal(out) => pyridoxal(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201669", "l": "Beta-catenin translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950724", "l": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19975", "l": "H(+) + S-methyl-5'-thioadenosine + spermine => S-adenosyl 3-(methylsulfanyl)propylamine + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10370", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate => 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140259", "l": "PRC1 complex binding", "d": ["Binding to a PRC1 complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708866", "l": "pro-F2R binds vorapaxar (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55207", "l": "5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8865994", "l": "GAB1 binds PTPN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77988", "l": "9-hydroxy-octadecanoate + a triacylglycerol => 9-(acyloxy)-octadecanoate + a 1,3-diacylglycerol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-181567", "l": "botC LC cleaves target cell STX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.141", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5656070", "l": "FGFBPs bind FGFs (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59050", "l": "CO2 + putrescine => D-ornithine + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57623", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + ML-236C carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12711", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75958", "l": "2-oxoglutarate + O2 + thebaine <=> CO2 + formaldehyde + oripavine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45223", "l": "coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein] <=> Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649801", "l": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74939", "l": "2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + O2 = a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.3.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0044689", "l": "7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity", "d": ["Catalysis of the reaction: 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H+ + L-methionine + NH4+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6781764", "l": "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24627", "l": "ATP + L-threonine + tRNA(Thr) <=> AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.122", "l": "\"L-cysteate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607721", "l": "Activation of NIK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018859", "l": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209891", "l": "Dopamine is oxidised to noradrenaline (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162096", "l": "carbovir diphosphate + ATP => carbovir triphosphate + ADP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446862", "l": "Hyperphosphorylated IRAK1 associates with TRAF6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9682603", "l": "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60656", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-183052", "l": "CBL binds to GRB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45240", "l": "a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA", "d": [], "t": []}, {"i": "EC:5.3.3.21", "l": "\"Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102799", "l": "glucosinolate glucohydrolase activity", "d": ["Catalysis of the reaction: H2O + a glucosinolate = alpha-D-glucose + a thiohydroximate-O-sulfate. Glucosinolates are a subclass of thioglucosides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55939", "l": "all-trans-4-hydroxyretinol + NAD(+) <=> all-trans-4-hydroxyretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018859", "l": "4-hydroxybenzoate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-171122", "l": "LDL + LDLR => LDL:LDLR complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-375339", "l": "Pannexin 1/Pannexin2 mediated neuronal gap junction communication (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9838289", "l": "CLPXP degrades mitochondrial matrix proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45563", "l": "L-isoleucine <=> D-allo-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2002440", "l": "Removal of fibrillar collagen C-propeptides (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786652", "l": "CHIT1 hydrolyses CHIT to 3xADGP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28689", "l": "orotate + ubiquinol-8 => (S)-dihydroorotate + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8866546", "l": "RNF5 and RNF185 ubiquitinate misfolded CFTR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43679", "l": "(9Z)-octadecenoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36972", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose => dTDP-4-dehydro-6-deoxy-alpha-D-allose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27942", "l": "(3R)-3-hydroxy-D-aspartate = NH4(+) + oxaloacetate", "d": [], "t": []}, {"i": "EC:4.3.1.27", "l": "\"threo-3-hydroxy-D-aspartate ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9681375", "l": "KIT binds ripretinib (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43220", "l": "guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.242", "l": "\"16S rRNA (guanine(1516)-N(2))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13459", "l": "CO2 + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] => 3-methyl-2-oxobutanoate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50600", "l": "acetyl-CoA + N-terminal L-seryl-[histone H2A] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690701", "l": "SHP1 binds p-CD22 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52767", "l": "(E)-1-(glutathione-S-yl)-2-(1H-indol-3-yl)acetohydroximate + H2O <=> (E)-1-(glycyl-L-cystein-S-yl)-2-(1H-indol-3-yl)acetohydroximate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15799", "l": "biliverdin IXalpha + H(+) + NADH => (4Z,15Z)-bilirubin IXalpha + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193981", "l": "CYP21A2 oxidises 17HPROG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28006", "l": "H2O + N(alpha)-methyl-L-tryptophan + O2 = formaldehyde + H2O2 + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174394", "l": "GSS:Mg2+ dimer synthesizes GSH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020275", "l": "ALOX15 oxidises DHA to 17(S)-Hp-DHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109701", "l": "PDPK1 binds PIP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16421", "l": "an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.2.7.5", "l": "\"aldehyde ferredoxin oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45013", "l": "H2O + N-octadecanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31225", "l": "beta-D-glucose + cis-2-coumarate => cis-beta-D-glucosyl-2-hydroxycinnamate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50005", "l": "H(+) + NADPH + O2 + tetracycline => 11a-hydroxytetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051993", "l": "abscisic acid glucose ester beta-glucosidase activity", "d": ["Catalysis of the reaction: abscisic acid glucose ester + H2O = abscisic acid + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112153", "l": "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981621", "l": "Neuroglobin:oxygen dissociates (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051991", "l": "UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity", "d": ["Catalysis of the reaction: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944522", "l": "miR-19a microRNA binds PTEN mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015565", "l": "threonine efflux transmembrane transporter activity", "d": ["Enables the transfer of threonine from the inside of the cell to the outside of the cell across a membrane."], "t": []}, {"i": "RHEA:35019", "l": "L-threonine(in) = L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787811", "l": "HAO2 tetramer oxidises 2OH-PALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10212", "l": "2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.48", "l": "\"5-aminovalerate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5618099", "l": "NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75903", "l": "ADP-D-glycero-beta-D-manno-heptose + L-seryl-[protein] = ADP + H(+) + O-(D-glycero-alpha-D-manno-heptosyl)-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51277", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (9S)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72452", "l": "a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out) => a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29570", "l": "2 chloride(in) + H(+)(out) <=> 2 chloride(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036479", "l": "peroxidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of peroxidase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71707", "l": "ethanol + NAD+ => acetaldehyde + NADH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10061", "l": "acetyl-CoA + D-tryptophan => CoA + H(+) + N-acetyl-D-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32161", "l": "A + H2O + queuosine(34) in tRNA => AH2 + epoxyqueuosine(34) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62016", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.63", "l": "\"EGF-domain serine xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63992", "l": "5-fluorocytidine + ATP = 5-fluorocytidine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76140", "l": "D-gluconate(in) => D-gluconate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-392064", "l": "G alpha (z) inhibits adenylate cyclase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20823", "l": "choline sulfate + H2O <=> choline + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55197", "l": "2-hydroxyoctadecanoyl-CoA => formyl-CoA + heptadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696664", "l": "PARP1 or PARP2 binds DDB2 at GG-NER site (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-212552", "l": "Caspase 3-mediated cleavage of PKC delta (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9856062", "l": "MITF-M dimer binds the CEACAM1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250264", "l": "TXNIP binds reduced thioredoxin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2730872", "l": "Activation of Calcineurin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63213", "l": "5-amino-6-(D-ribitylamino)uracil + methylglyoxal => 5-(2-oxopropylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634846", "l": "NPAS4 binds ARNTL (BMAL1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854645", "l": "IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78164", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47876", "l": "a ganglioside GD1b + H2O = a ganglioside GM1 + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73588", "l": "CTP(out) + UMP(in) => CTP(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35499", "l": "11-oxo-beta-amyrin + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = glycyrrhetinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.115", "l": "\"11-oxo-beta-amyrin 30-oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9835189", "l": "NCK1 binds PKR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41055", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + dodecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-dodecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186780", "l": "Degradation of Ub-SMAD7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53827", "l": "NAD(+) + taurochenodeoxycholate <=> 7-oxotaurolithocholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72701", "l": "NAD(+) + propanoate => acrylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9860273", "l": "Dimerization of p-S446-IRF5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192160", "l": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299318", "l": "Activation of TASK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004960", "l": "thromboxane receptor activity", "d": ["Combining with a thromboxane (TXA) to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52272", "l": "(1H-indol-3-yl)-N-methylmethanamine + S-adenosyl-L-methionine = gramine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173483", "l": "BAMBI interferes with the interaction of type I receptor with type II receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8869694", "l": "oxPL binds CD14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48081", "l": "abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] => ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56504", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008926", "l": "mannitol-1-phosphate 5-dehydrogenase activity", "d": ["Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422051", "l": "Cleavage of the signal peptide of Preproghrelin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8937191", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1977296", "l": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-203716", "l": "eNOS:Caveolin-1 complex binds to Nostrin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190065", "l": "Activated TrkA receptor internalizes to endosomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5610746", "l": "SCF(beta-TrCP) ubiquitinates p-GLI3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669250", "l": "PAK1 phosphorylates FLNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0008554", "l": "P-type sodium transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out); by a phosphorylative mechanism."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73916", "l": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52872", "l": "17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44015", "l": "(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) <=> (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6790454", "l": "SUMOylation of XPC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-188350", "l": "CAK-mediated phosphorylation of Cyclin E:Cdk2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40560", "l": "dTDP-beta-L-evernosamine + NADPH + O2 => dTDP-N-hydroxy-beta-L-evernosamine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871266", "l": "YAP1 binds TEAD3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.940402076938994", "identifiers": [{"i": "GO:0004721", "l": "phosphoprotein phosphatase activity", "d": ["Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76283", "l": "guanine(out) + Na(+)(out) = guanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69822", "l": "H(+) + hypotaurine + NADPH + O2 <=> H2O + NADP(+) + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56524", "l": "A + dihydro-heme d1 = AH2 + heme d1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975829", "l": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679787", "l": "HDAC1:2-containing complex binds HDAC2 Inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41295", "l": "H2O + N-(hexanoyl)sphing-4-enine = hexanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4755536", "l": "PIAS3 SUMOylates RELA with SUMO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9845538", "l": "ST3GAL2,3 transfer Neu5Ac to gangliosides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211960", "l": "CYP2U1 19-hydroxylates ARA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41814", "l": "butanoyl-[ACP] + NADP(+) => (2E)-butenoyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17502", "l": "H2O + polyneuridine aldehyde => 16-epivellosimine + CO2 + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39047", "l": "26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052672", "l": "CTP:geranylgeraniol kinase activity", "d": ["Catalysis of the reaction: geranylgeraniol + CTP = all-trans-geranyl-geranyl monophosphate + CDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-209924", "l": "Dopa is decarboxylated to dopamine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77526", "l": "butanal + hydrogen cyanide <=> (2S)-2-hydroxypentanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69388", "l": "(S)-2-ureidoglycine + carbamoyl phosphate = allantoate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:2.1.3.16", "l": "\"ureidoglycine carbamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.2.-", "l": "\"Amidinotransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192832", "l": "Initiation of cRNA Synthesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52691", "l": "3-phenyllactate + NAD(+) <=> 3-phenylpyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71761", "l": "2-oxoglutarate(in) + heptanedioate(out) => 2-oxoglutarate(out) + heptanedioate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174959", "l": "The acetyl group from acetyl-CoA is transferred to the NAT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13656", "l": "[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose <=> [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56391", "l": "(5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 <=> (4,5-dichloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22374", "l": "3-oxopropanoate + H(+) + H2O2 + nitrite => H2O + O2 + propionate 3-nitronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29785", "l": "ADP + H(+) + L-cysteine(out) + phosphate => ATP + H2O + L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67370", "l": "acetate + L-glutamine => H2O + N-acetyl-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210404", "l": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23199", "l": "3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine <=> 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854899", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160089", "l": "internal N(7)-methylguanine-containing RNA reader activity", "d": ["A protein adaptor that recognizes and binds an RNA molecule modified by N(7)-methylguanine (m7G), a modification present at internal sites of mRNAs and some non-coding RNAs."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788611", "l": "HYKK phosphorylates 5HLYS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78617", "l": "diphosphate + L-lysyl-5'-AMP => ATP + H(+) + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25557", "l": "9alpha-copalyl diphosphate => diphosphate + stemod-13(17)-ene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40863", "l": "FAD + H(+) + heptadecanoyl-CoA = FADH2 + trans-2-heptadecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429415", "l": "SYK binds to integrin alphaIIb beta3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-182990", "l": "Sprouty sequesters CBL away from active EGFR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73806", "l": "AIR + CO2 => CAIR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954513", "l": "NAA translocates from mitochondrial matrix to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23057", "l": "urea => cyanamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31217", "l": "(5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH => (5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9658445", "l": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10273", "l": "a 1,2-diacyl-sn-glycerol + ATP => a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5681987", "l": "LC3 is cleaved by ATG4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692755", "l": "CDK1 phosphorylates MAPK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031774", "l": "leukotriene receptor binding", "d": ["Binding to a leukotriene receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36542", "l": "hexadecanoyl-CoA + sphinganine <=> CoA + H(+) + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9024334", "l": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102884", "l": "alpha-zingiberene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = zingiberene + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38773", "l": "1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine => 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38748", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(9Z-octadecenoyl) ethanolamine => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 2-[(9Z)-octadecenoylamino]ethyl (9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033413", "l": "UGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a UGU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5673768", "l": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1470010", "l": "Dimerization of STATs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6804402", "l": "TP53 binds POU4F1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71083", "l": "estrone 3-sulfate(out) + 2 Na(+)(out) = estrone 3-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70722", "l": "L-alanine(in) <=> L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48461", "l": "1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O => 2-octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) + octanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2129375", "l": "Elastin cross-linking by lysyl oxidase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60437", "l": "3-methylbutyl acetate + H2O => 3-methylbutanol + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57683", "l": "a flavanone + O2 + reduced [NADPH--hemoprotein reductase] <=> a flavone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41092", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => 1-(9Z-octadecenoyl)-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194796", "l": "botB LC cleaves target cell VAMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004491", "l": "methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity", "d": ["Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59862", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->6)-N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP => 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67587", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209921", "l": "Monoiodinated tyrosine can be deiodinated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19175", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) => H(+) + NADH + naphthalene + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73635", "l": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66407", "l": "ATP + glutathione(in) + H2O + taurocholate(in) <=> ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018017", "l": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952618", "l": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804762", "l": "TP53 forms homotetramers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14010", "l": "2 dimethylallyl diphosphate => (R,R)-chrysanthemyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655845", "l": "Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9851946", "l": "FIRRM binds PLK1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63208", "l": "5-amino-6-(D-ribitylamino)uracil + glyoxal = 5-(2-oxoethylideneamino)-6-(D-ribitylamino)uracil + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8850527", "l": "PDCL releases folded G-beta from TRiC/CCT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26171", "l": "3-fumarylpyruvate + H2O <=> fumarate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56051", "l": "daidzein + UDP-alpha-D-glucose <=> daidzein 7-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814119", "l": "TRiC/CCT binds unfolded G-protein beta subunit (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70016", "l": "O2 + reduced [NADPH--hemoprotein reductase] + teasterone => 7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14736", "l": "Ag(+)(in) + ATP + H2O <=> ADP + Ag(+)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388529", "l": "Cholecystokinin receptors bind cholecystokinin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5358343", "l": "HHAT palmitoylates Hh N-terminal fragment (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679255", "l": "WIPI2 binds ATG12:ATG5:ATG16L (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696534", "l": "USP18 deubiquitinates TAK1:TAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-380949", "l": "AMPK is dephosphorylated (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-381026", "l": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21187", "l": "a dolichyl phosphate + GDP-alpha-D-mannose <=> a dolichyl beta-D-mannosyl phosphate + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23482", "l": "dimethylmaleate => 2-methylene-3-methylsuccinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25299", "l": "acetaldehyde + H2O + NADP(+) => acetate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9693214", "l": "RHOD binds effectors at the mitochondrial outer membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68294", "l": "CoA + O-nonanoyl-L-seryl-[protein] => L-seryl-[protein] + nonanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810937", "l": "Lamellar bodies bind the early cornified envelope (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11868", "l": "D-arabinitol + NADP(+) = D-ribulose + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661217", "l": "MT1A binds zinc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-727819", "l": "TAK1 phosphorylates MKK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707977", "l": "CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31692", "l": "(9Z,12Z)-octadecadienoate + O2 => (9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70072", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sitosterol => (22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807877", "l": "ARFGAPs stimulate ARF GTPase activity (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55030", "l": "an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682709", "l": "LGI4 binds ADAM22,23,11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176521", "l": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008688", "l": "3-(3-hydroxyphenyl)propionate hydroxylase activity", "d": ["Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174121", "l": "Association of Securin with Cdc20:APC/C complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9680408", "l": "BRD4 binds fedratinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17537", "l": "(R)-carnitinamide + H2O = (R)-carnitine + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.73", "l": "\"carnitinamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8941895", "l": "Formation of CDK4/6:CCND complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71401", "l": "OGDH dimer decarboxylates 2-OG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71993", "l": "(-)-astellatene + diphosphate => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-156930", "l": "GTP-binding activates eEF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47085", "l": "4-methylsulfanyl-2-oxobutanoate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44459", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine <=> a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-acyl-N-acylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1964505", "l": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008111", "l": "alpha-methylacyl-CoA racemase activity", "d": ["Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-870269", "l": "Gastrin binds to CCK-B receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40515", "l": "6-deoxy-6-sulfo-D-fructose 1-phosphate = (2S)-3-sulfolactaldehyde + dihydroxyacetone phosphate", "d": [], "t": []}, {"i": "EC:4.1.2.57", "l": "\"sulfofructosephosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39106", "l": "ATP + H2O + sitosterol(in) <=> ADP + H(+) + phosphate + sitosterol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3780979", "l": "CCS transfers Cu to SOD1 (mitochondrial) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9679028", "l": "JAK3 binds JAK3 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30384", "l": "(2E,6E)-farnesyl diphosphate => (-)-7-epi-alpha-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18452", "l": "A + arsenite + H2O <=> AH2 + arsenate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64365", "l": "prostaglandin G2 => (15S)-15-hydroperoxy-prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1614546", "l": "Sulfate is exported to the cytosol in exchange for dicarboxylate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52945", "l": "cholate + UDP-alpha-D-glucuronate => choloyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12290", "l": "an alcohol + L-fucose => an alpha-L-fucoside + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42996", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (R)-cembrene A + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.150", "l": "\"cembrene A synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25792", "l": "ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:7.2.2.8", "l": "\"P-type Cu(+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68354", "l": "3',2'-cGAMP + diphosphate => pppA(2'-5')pG", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5695964", "l": "ABHD14B hydrolyses PNPB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67329", "l": "(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione => trichosetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983696", "l": "The Immunoglobulin of the BCR binds antigen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72850", "l": "adenosine 3',5'-bisphosphate(in) + ADP(out) <=> adenosine 3',5'-bisphosphate(out) + ADP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114354", "l": "SMAC binds XIAP:Caspase-7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64391", "l": "4 A + sn-3-O-phytanylglycerol 1-phosphate <=> 4 AH2 + sn-3-O-(geranylgeranyl)glycerol 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39407", "l": "3-oxo-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-139899", "l": "Sequestration of BAD protein by 14-3-3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37629", "l": "1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA => (9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69195", "l": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165680", "l": "Formation of active mTORC1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.61", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6795667", "l": "MDM2 translocates to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40170", "l": "hexadecanoyl-CoA + O2 <=> (2E)-hexadecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9824894", "l": "TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73068", "l": "an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O => an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58850", "l": "(6E)-8-hydroxygeranial + H(+) + NADH => (6E)-8-hydroxygeraniol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58611", "l": "2 L-ascorbate + N-decanoylglycine + O2 <=> H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29521", "l": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) => alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-177157", "l": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34953", "l": "3-hydroxypropanoate(in) => 3-hydroxypropanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36681", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-allose + H(+) + NADH => dTDP-6-deoxy-alpha-D-allose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1227671", "l": "Recruitment of HDAC1 by p107 (RBL1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70920", "l": "chloride(out) + dopamine(out) + Na(+)(out) => chloride(in) + dopamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9678737", "l": "IFNAR1:TYK2 binds TYK2 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83790", "l": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33002", "l": "(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65023", "l": "L-ornithine + succinyl-CoA <=> CoA + H(+) + N(2)-succinyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1252013", "l": "Translocation of ERBB4s80 to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76505", "l": "4-O-beta-D-glucosyl-vanillin + acetate => 4-O-beta-D-glucosyl-trans-ferulate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182171", "l": "Degradation of CD8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54880", "l": "(4R,7R)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one = (3R)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5617828", "l": "TRIP11:IFT20 dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61822", "l": "epiandrosterone 3-beta-D-glucoside + H(+) + UDP => 3beta-hydroxy-5alpha-androstan-17-one + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34910", "l": "molybdate(in) <=> molybdate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-209910", "l": "Iodide is taken up by thyroid epithelial cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75764", "l": "(9E,11E)-octadecadienoate + H2O => 10-hydroxy-(11E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45609", "l": "H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17142", "l": "glycine + oxaloacetate => glyoxylate + L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.51128060092941", "identifiers": [{"i": "GO:0016641", "l": "oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035500", "l": "MH2 domain binding", "d": ["Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48441", "l": "H2O + long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => a fatty acid + H(+) + long chain 2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46079", "l": "(2E)-eicosenoyl-CoA + H(+) + NADH <=> eicosanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39907", "l": "2-oxoglutarate + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucose + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.106", "l": "\"dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45612", "l": "H2O + N-octanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-octanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9638125", "l": "PGM1:Mg2+ isomerises G1P to G6P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840429", "l": "DELE1(143-515) binds EIF2AK1 (HRI) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188191", "l": "APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41040", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + dodecanoyl-CoA => 1-O-hexadecyl-2-acetyl-3-dodecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8855130", "l": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76659", "l": "butanal + H2O + NADP(+) = butanoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67593", "l": "a 5'-end CoA-ribonucleoside in mRNA + H2O => (R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654673", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67055", "l": "AH2 + asnovolin J + O2 <=> A + asnovolin A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37127", "l": "2-oxoglutarate + dioxidophosphate + H2O2 = CO2 + H(+) + phosphonate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52286", "l": "11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8876696", "l": "SOAT1,2 transfer acyl group to CHOL forming CHEST (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783955", "l": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912359", "l": "HES1 binds TLE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65359", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4-phosphate) + ATP <=> 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.287", "l": "\"phthioceranic/hydroxyphthioceranic acid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033921", "l": "capsular-polysaccharide endo-1,3-alpha-galactosidase activity", "d": ["Catalysis of the random hydrolysis of (1->3)-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102902", "l": "isopimaradienal hydroxylase activity", "d": ["Catalysis of the reaction: isopimaradienal + NADPH + O2 = isopimaric acid + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44586", "l": "(9Z)-octadecenoate + H(+) + sn-glycero-3-phospho-(1'-sn-glycerol) => 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705584", "l": "HMGCR dimer binds statins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69740", "l": "phenylsuccinate + succinyl-CoA => 3-phenylsuccinyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862700", "l": "CMKLR1 binds Resolvin E1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193143", "l": "CYP19A1 hydroxylates TEST to EST17b (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9757256", "l": "MCM3 binds MCM5 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696914", "l": "USP28 deubiquitinates CLSPN and MYC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683393", "l": "nsp15 binds nsp8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-75861", "l": "NTP Binds Active Site of RNA Polymerase II (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661397", "l": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5672817", "l": "Active MTORC1 binds the ULK1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49603", "l": "ATP + CoA + octanedioate <=> AMP + diphosphate + octanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497866", "l": "Peroxynitrite can oxidise BH4 to the BH3 radical (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9823904", "l": "TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37209", "l": "1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA => (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30350", "l": "ATP + IDP <=> ADP + ITP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-751001", "l": "Inactive G alpha (i) reassociates with G beta:gamma (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23161", "l": "L-rhamnopyranose => L-rhamnulose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56721", "l": "2 Fe(III)-[cytochrome c] + L-cysteinyl-[SoxY protein] + thiosulfate => 2 Fe(II)-[cytochrome c] + 2 H(+) + S-sulfosulfanyl-L-cysteinyl-[SoxY protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61676", "l": "holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP = AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30951", "l": "(2E,6E)-farnesyl diphosphate + H2O = alpha-eudesmol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.85", "l": "\"alpha-eudesmol synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77434", "l": "a ganglioside GT2 + UDP-alpha-D-galactose <=> a ganglioside GT1c + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59296", "l": "an N-acylglycine + 2 L-ascorbate + O2 = an N-acyl-(2S)-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35844", "l": "1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11365", "l": "ATP + H2O + pyruvate => AMP + 2 H(+) + phosphate + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45002", "l": "CoA + O-3-hydroxybutanoyl-(R)-carnitine => (R)-carnitine + 3-hydroxybutanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1454757", "l": "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690340", "l": "Defective ABCC6 does not transport organic anion from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29552", "l": "H2O + UDP-alpha-D-glucose => alpha-D-galactose 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390595", "l": "Calcium Binds Troponin-C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694341", "l": "Spike protein gets palmitoylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8954117", "l": "E2F6:TFDP1 binds EPC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5229132", "l": "AP4 binds APP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034988", "l": "Fc-gamma receptor I complex binding", "d": ["Binding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59965", "l": "L-seryl-[protein] + octanoyl-CoA => CoA + O-octanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50987", "l": "prostaglandin E2(out) <=> prostaglandin E2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-377641", "l": "Clustering of Integrin alphaIIb beta3 complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161614", "l": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13064", "l": "O2 + S-sulfanylglutathione <=> glutathione S,S-dioxide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29565", "l": "ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate => ATP + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56273", "l": "4 Fe(III)-[cytochrome cL] + H2O + methanol => 4 Fe(II)-[cytochrome cL] + formate + 5 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004849", "l": "uridine kinase activity", "d": ["Catalysis of the reaction: ATP + uridine = ADP + UMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5624132", "l": "UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008387", "l": "steroid 7-alpha-hydroxylase activity", "d": ["Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36863", "l": "(9Z)-octadecenoyl-CoA + AH2 + O2 = (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55466", "l": "11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2396395", "l": "HSPG2 (perlecan) binds alpha-dystroglycan (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69693", "l": "a ganglioside beta-DGlcNAc-(1->6)-GA1 + H(+) + UDP => a ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928631", "l": "GIT1 binds bPIX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428625", "l": "Vesicular inhibitory amino acid transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33757", "l": "(4R)-hydroxysphinganine + hexadecanoate => H2O + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83788", "l": "Binding of TFIIIC to Type 2 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51866", "l": "8-geranylesculetin + diphosphate => (2E)-geranyl diphosphate + esculetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64521", "l": "acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA => A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36464", "l": "glycyl-L-glutamate + H2O => glycine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43583", "l": "A + D-arginine <=> AH2 + iminoarginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14515", "l": "ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate => ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22515", "l": "3 H(+) + precorrin-8X <=> hydrogenobyrinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030196", "l": "cyanide hydratase activity", "d": ["Catalysis of the reaction: formamide = H2O + hydrogen cyanide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654651", "l": "Activated FGFR4 binds FRS3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.138", "l": "\"coumarin 8-geranyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15456", "l": "S-adenosyl-L-methionine + sarcosine <=> H(+) + N,N-dimethylglycine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64321", "l": "(9Z)-hexadecenoyl-CoA + cholesterol => cholesteryl (9Z)-hexadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57871", "l": "(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 <=> (E)-2,4-dihydroxycinnamoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004824", "l": "lysine-tRNA ligase activity", "d": ["Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31266", "l": "but-3-ynal + H(+) + pyrroloquinoline quinol <=> but-3-yn-1-ol + pyrroloquinoline quinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36344", "l": "2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2 => 2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62788", "l": "2 fonsecin B + H(+) + NADPH + O2 = aurasperone B + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9636684", "l": "ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59556", "l": "H2O + N,N'-diacetylchitobiono-1,5-lactone = H(+) + N,N'-diacetylchitobionate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163090", "l": "Elongation Of The Telomeric Chromosome End (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6784204", "l": "JAKs bind OSMR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43241", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032050", "l": "clathrin heavy chain binding", "d": ["Binding to a clathrin heavy chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673288", "l": "ppDVL binds RAC1:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45756", "l": "(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1254392", "l": "PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.103", "l": "\"phosphoethanolamine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70193", "l": "3'-NADP(+) + ADP + H(+) => ATP + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45823", "l": "mesaconate + succinyl-CoA <=> 2-methylfumaryl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047175", "l": "galactosylacylglycerol O-acyltransferase activity", "d": ["Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76594", "l": "N,N-dimethylglycine(out) + Na(+)(out) <=> N,N-dimethylglycine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67309", "l": "(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one => (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41857", "l": "3-oxodecanoyl-[ACP] + H(+) + NADPH => (3R)-hydroxydecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78127", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141310", "l": "FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9844360", "l": "EBF2 binds Blnc1 lncRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173481", "l": "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61574", "l": "(15S)-hydroperoxy-(11Z,13E)-eicosadienoate => (11Z,14Z)-eicosadienoate + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6811522", "l": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9018594", "l": "MECP2 binds LBR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21477", "l": "[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->3)-beta-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9794523", "l": "SLC22A1 transports Cipro into renal cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187309", "l": "SMAD2/3:SMAD4 heterotrimer binds SP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54104", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64155", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate <=> alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49722", "l": "CO2 + 2 H2O + NAD(+) + violacein => 2 H(+) + NADH + 2 O2 + protoviolaceinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-71401", "l": "OGDH dimer decarboxylates 2-OG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5653936", "l": "Formation of Ragulator complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39956", "l": "(9Z-octadecenoyl)-glycerol + H2O => (9Z)-octadecenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69914", "l": "adenosine(out) + 2 Na(+)(out) <=> adenosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46100", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = cortisol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190519", "l": "Internalization of gap junction plaques (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54952", "l": "ATP + CoA + nonanoate = AMP + diphosphate + nonanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.11.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23379", "l": "L-threonate + NAD(+) <=> 3-dehydro-D-erythronate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-266328", "l": "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5610722", "l": "CK1 phosphorylates p-GLI3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6800490", "l": "ATM phosphorylates PIDD1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3149563", "l": "MMADHC targets transport of cytosolic cob(II)alamin to mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362427", "l": "Hh-Np binds GPC5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-428941", "l": "P2Y purinoceptor 1 activates MAP kinase p38 alpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949399", "l": "CAR translocates from the cytosol to the mitochondrial intermembrane space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40387", "l": "1,2-di-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol + ATP = 1,2-di(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho-1D-myo-inositol 5-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9024766", "l": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654425", "l": "Activated FGFR4 binds SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76843", "l": "H2O + NAD(+) + octylamine = H(+) + NADH + NH4(+) + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.99.10", "l": "\"4,4'-diapolycopenoate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008870", "l": "galactoside O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32050", "l": "H2O + P(1),P(6)-bis(5'-adenosyl) hexaphosphate <=> adenosine 5'-pentaphosphate + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73606", "l": "CMP(in) + CTP(out) <=> CMP(out) + CTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686286", "l": "PALM-C100-CKAP4 transports SFTPAs from extracellular region to lamellar body (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047194", "l": "indoleacetylglucose-inositol O-acyltransferase activity", "d": ["Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = 1L-1-O-(indol-3-yl)acetyl-myo-inositol + D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46271", "l": "an N-acyl-(4R)-4-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (4R,8E)-4-hydroxysphingenine ceramide + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389540", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67440", "l": "H2O + N(alpha)-acetyl-L-methionine = acetate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43521", "l": "2-carboxy-5-(dihydroxymethyl)furan + O2 => 2,5-dicarboxyfuran + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58403", "l": "heptan-1-ol + NADP(+) <=> H(+) + heptanal + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56885", "l": "adenosine(32) in tRNA + S-adenosyl-L-methionine => 2'-O-methyladenosine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20273", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine", "d": [], "t": []}, {"i": "EC:1.14.16.1", "l": "\"phenylalanine 4-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54871", "l": "(2E)-butenoyl-[ACP] + H(+) + NADH <=> butanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033973", "l": "dCTP deaminase (dUMP-forming) activity", "d": ["Catalysis of the reaction: dCTP + 2 H2O = diphosphate + dUMP + H+ + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052792", "l": "endo-xylogalacturonan hydrolase activity", "d": ["Catalysis of the endohydrolysis of xylogalacturonate by cleavage of the alpha-(1,4)-linkage. Xylogalacturonate (XGA) is composed of a chain of alpha-(1,4)-linked D-galacturonic acid residues with beta-D-xylose substituted at the O3 position."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69684", "l": "daidzein 7-O-beta-D-glucoside + H2O => beta-D-glucose + daidzein + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55307", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-octadecanoyl-sn-glycero-3-phosphate <=> 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9612501", "l": "SGK phosphorylates CREB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44488", "l": "3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40617", "l": "2,3-didecanoyl-sn-glycerol + decanoate + H(+) => H2O + tridecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2214324", "l": "Collagen type VII dimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45930", "l": "4-hydroxy-6-(16-hydroxy-2-oxohexadecyl)pyran-2-one + 3 CO2 + 4 CoA => 15-hydroxypentadecanoyl-CoA + 3 H(+) + 3 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19700", "l": "11-cis-retinyl hexadecanoate + H2O <=> 11-cis-retinol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9017488", "l": "RHOJ GAPs stimulate RHOJ GTPase activity (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023627", "l": "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69915", "l": "guanosine(out) + 2 Na(+)(out) = guanosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5623643", "l": "RDH13 reduces atRAL to atROL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139893", "l": "Granzyme-B activates BID by cleavage (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53833", "l": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 => a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10162", "l": "H(+) + keto-L-sorbose + NADH => L-iditol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5655315", "l": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8959781", "l": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027273", "l": "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811411", "l": "GBF1 recruits ARF:GDP to the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14121", "l": "3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693566", "l": "TP53BP1 associates with H4K20Me2 at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446894", "l": "TRAF6 binding leads to IRAK1:TRAF6 release (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0098808", "l": "mRNA cap binding", "d": ["Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an mRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15833", "l": "(S)-4-hydroxymandelate + H(+) + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.19", "l": "\"4-hydroxymandelate oxidase (decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77271", "l": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018807", "l": "RAC3 GDIs block activation of RAC3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606273", "l": "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56758", "l": "4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin] => 5 H(+) + 3 O2 + obtusifoliol + 6 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68019", "l": "(2E,6E,10E)-geranylgeranyl phosphate + H2O <=> (2E,6E,10E)-geranylgeraniol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852127", "l": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75238", "l": "TRAIL binds TRAIL receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52409", "l": "4-phospho-D-erythronate + NAD(+) => CO2 + dihydroxyacetone phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42982", "l": "2-aminoprop-2-enoate + phenol => L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9823816", "l": "OPTN binds CASP8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209960", "l": "Diiodinated tyrosine can be deiodinated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40534", "l": "2 H(+) + narbomycin + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + neopikromycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43032", "l": "3-chloro-D-alanine = 2-aminoprop-2-enoate + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30862", "l": "dITP + H2O <=> dIDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018606", "l": "benzenesulfonate dioxygenase activity", "d": ["Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031208", "l": "POZ domain binding", "d": ["Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.5.2", "l": "\"L-cysteine S-thiosulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209361", "l": "STAT92E binds to phosphorylated HOP and phosphorylated DOME (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26492", "l": "a ketone + H(+) + H2O2 + nitrite => a secondary nitroalkane + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018562", "l": "3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187355", "l": "PMEPA1 sequesters phosphorylated SMAD2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19125", "l": "glyoxylate + L-serine = 3-hydroxypyruvate + glycine", "d": [], "t": []}, {"i": "EC:2.6.1.45", "l": "\"serine--glyoxylate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.25", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194678", "l": "CYP51A1 demethylates LNSOL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753277", "l": "SULT dimers sulfate APAP to APAP-SO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5665727", "l": "FMNL2 binds CDC42:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14073", "l": "3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.16", "l": "\"hydroxyglutamate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061685", "l": "diphthine methylesterase activity", "d": ["Catalysis of the reaction: diphthine methyl ester + H2O = diphthine + H+ + methanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51974", "l": "an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => an L-polyhomomethionine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174451", "l": "Recruitment of DNA2 endonuclease to the C strand (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.365978052393643", "identifiers": [{"i": "GO:0003700", "l": "DNA-binding transcription factor activity", "d": ["A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48140", "l": "2 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] = 2 oxidized [2Fe-2S]-[ferredoxin] + red chlorophyll catabolite", "d": [], "t": []}, {"i": "EC:1.14.15.17", "l": "\"pheophorbide a oxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380234", "l": "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41793", "l": "holo-[ACP] + malonyl-CoA => CoA + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810594", "l": "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446198", "l": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694445", "l": "CNIH1 binds TFGA and AREG precursors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1474197", "l": "Collagen type II degradation by MMP1,3,8,13,PRSS2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9853878", "l": "FIGNL1 binds DMC1, RAD51 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41775", "l": "a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GQ1b (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68722", "l": "26-hydroxylanosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75038", "l": "1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate <=> 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39563", "l": "(2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH = (23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013488", "l": "HEYL gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2395879", "l": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013438", "l": "RHOD binds effectors at the endosome membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678927", "l": "UNC93B1 delivers endosomal full-length TLRs to endolysosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419644", "l": "Transphosphorylation of pLIMK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71618", "l": "(S)-malate(in) + sulfate(out) <=> (S)-malate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000434", "l": "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14807", "l": "ADP + D-allose 6-phosphate + H(+) => ATP + D-allose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264976", "l": "Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875661", "l": "GGA3 associates with activated MET receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867047", "l": "PTPN3 dephosphorylates EPS15 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8871376", "l": "p-Y389,400-RUFY1 binds PI3P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66429", "l": "D-arabinose(out) + H(+)(out) => D-arabinose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29692", "l": "alpha-maltotetraose + phosphate => alpha-D-glucose 1-phosphate + alpha-maltotriose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.49", "l": "\"1-pyrroline-2-carboxylate reductase [NAD(P)H]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.362", "l": "\"alpha-(1->3) branching sucrase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30206", "l": "H2O + P(1),P(4)-bis(5'-guanosyl) tetraphosphate <=> 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380905", "l": "Serotonin loaded synaptic vesicle docking and priming (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-168870", "l": "Neuraminidase enzymatic release from sialic acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2404135", "l": "RBP4 binds atROL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75402", "l": "2 H(+)(out) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(out) <=> 2 H(+)(in) + N-formyl-L-methionyl-L-leucyl-L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692867", "l": "HRH3 binds pitosilant (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11583", "l": "a CDP-1,2-diacyl-sn-glycerol + myo-inositol <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.44", "l": "\"nuclear-inclusion-a endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0051575", "l": "5'-deoxyribose-5-phosphate lyase activity", "d": ["Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654392", "l": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1614460", "l": "Dimerization of procollagen type VI (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944214", "l": "Association of procollagen type I (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22663", "l": "a fatty acid + ATP + holo-[ACP] <=> a fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756134", "l": "UGT1A3 lactonizes 2-OH-ATV to 2-OH-ATVL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30720", "l": "acetyl-CoA + propanoyl-CoA => 2-methyl-3-oxobutanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70143", "l": "6alpha-hydroxy-28-nortyphasterol + O2 + reduced [NADPH--hemoprotein reductase] = 28-nortyphasterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6804100", "l": "HMGB1 binds LPS (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77904", "l": "2 Fe(III)-[cytochrome c] + succinate => 2 Fe(II)-[cytochrome c] + fumarate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9679028", "l": "JAK3 binds JAK3 inhibitors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16089", "l": "H2O + phosphoethanolamine = ethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25330", "l": "(R)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61677", "l": "holo-[peptidyl-carrier protein] + L-cysteinyl-5'-AMP => AMP + H(+) + L-cysteinyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65451", "l": "butanoyl-CoA + ethanol <=> CoA + ethyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72747", "l": "leukotriene E4(out) = leukotriene E4(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196017", "l": "Dynamin is recruited to the gap junction plaque (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33255", "l": "2-demethylmenaquinol-7 + S-adenosyl-L-methionine = H(+) + menaquinol-7 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688289", "l": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52798", "l": "Ni(2+) + sirohydrochlorin => 2 H(+) + Ni-sirohydrochlorin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204873", "l": "Interaction of Tie2 and Shp2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111966", "l": "GRK2 binds CALM1:4Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604731", "l": "Autocatalytic activation of MMP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985201", "l": "ABCE1 binds RNASEL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23970", "l": "(E)-ferulate + 2 H(+) + NADH => (E)-coniferaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.12", "l": "\"glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5631885", "l": "PRDX1 overoxidizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12847", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate => [L-4-(L-arginin-2-N-yl)aspartate](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202478", "l": "Interaction and oligomerization of MALT1 to Bcl10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047955", "l": "glycerol dehydrogenase (acceptor) activity", "d": ["Catalysis of the reaction: A + glycerol = AH(2) + glycerone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199404", "l": "CD40L binds CD40 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008750", "l": "proton-translocating NAD(P)+ transhydrogenase activity", "d": ["Catalysis of the reaction: H+(in) + NAD+ + NADPH = H+(out) + NADH + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75173", "l": "GDP + H(+) + NADP(+) => GTP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17382", "l": "(9Z,12Z)-octadecadienoate => (9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56514", "l": "3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate => 3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33836", "l": "H2O + N-hexacosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + hexacosanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8849900", "l": "SALMs1-3 bind each other in cis interactions (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9034714", "l": "NTRK3 dimers trans-autophosphorylate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38479", "l": "N(alpha)-methyl-L-histidine + S-adenosyl-L-methionine = H(+) + N(alpha),N(alpha)-dimethyl-L-histidine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73792", "l": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4551648", "l": "SUMOylation of TDG with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55137", "l": "ATP + D-alanine + H(+) => D-alanyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63092", "l": "H(+) + ilicicolin A + NADPH + O2 = H2O + ilicicolin A epoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140941", "l": "histone H4K20me methyltransferase activity", "d": ["Catalysis of the reaction: N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H+ + N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the monomethlyated lysine residue at position 20 of histone H4, producing H4K20me2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49379", "l": "12-hydroxyoctadecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 12,18-dihydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9858752", "l": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1362465", "l": "GHBP binds GHR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70686", "l": "(R)-normetanephrine + S-adenosyl-L-methionine <=> (R)-metanephrine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43177", "l": "cytidine(2870) in 25S rRNA + S-adenosyl-L-methionine => 5-methylcytidine(2870) in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53197", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone => 16alpha,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44566", "l": "4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate => 4-hydroxybenzoate + all-trans-decaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3785711", "l": "Telomere shortening during replicative exhaustion (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32605", "l": "(6E)-8-oxogeraniol + H(+) + NADPH => (6E)-8-hydroxygeraniol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5682893", "l": "ATG12:ATG7:CysO572-ATG7 binds ATG10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20980", "l": "2 (4Z,15Z)-bilirubin IXalpha + O2 = 2 biliverdin IXalpha + 2 H2O", "d": [], "t": []}, {"i": "EC:1.3.3.5", "l": "\"bilirubin oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437300", "l": "SLC31A1 transports Cu2+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69127", "l": "Formation of the Flap Intermediate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28283", "l": "(S)-beta-bisabolene => (S)-beta-macrocarpene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186643", "l": "MEN1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090416", "l": "nicotinate transmembrane transporter activity", "d": ["Enables the transfer of nicotinate from one side of a membrane to the other."], "t": []}, {"i": "REACT:R-HSA-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1253343", "l": "WWOX binds ERBB4s80 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211191", "l": "Association of DFF with alpha:beta importin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693967", "l": "PXLP-K754-GLDC dimer decarboxylates Gly (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47444", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + CoA = (5Z)-tetradecenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47724", "l": "glutathione = 5-oxo-L-proline + L-cysteinylglycine", "d": [], "t": []}, {"i": "EC:4.3.2.7", "l": "\"glutathione-specific gamma-glutamylcyclotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58538", "l": "CoA + H(+) + N-hexadecanoylglycine => glycine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12301", "l": "S-adenosyl-L-methionine + uridine(47) in tRNA(Phe) => 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-996727", "l": "REST recruits the BHC complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73307", "l": "H(+)(in) + L-aspartate(out) + phosphate(in) = H(+)(out) + L-aspartate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052869", "l": "arachidonic acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64931", "l": "dADP + H2O <=> dAMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421459", "l": "uroporphyrinogen I => coproporphyrinogen I + 4 CO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77374", "l": "[alpha-N-acetylneuraminyl-(2->8)](n)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP-N-acetyl-beta-neuraminate <=> [alpha-N-acetylneuraminyl-(2->8)](n+1)-alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39470", "l": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH <=> (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42986", "l": "diphosphate + pimara-8(14),15-diene => (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483186", "l": "PC is converted to PS by PTDSS1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3322003", "l": "Autoglucosylation of GYG1 complexed with GYS1-b (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204824", "l": "Interaction of Tie2 and Ang4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4086088", "l": "SUMOylation of NPM1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23580", "l": "prostaglandin H2 = prostaglandin I2", "d": [], "t": []}, {"i": "EC:5.3.99.4", "l": "\"prostaglandin-I synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23312", "l": "2 sucrose = 1(F)-beta-D-fructosylsucrose + D-glucose", "d": [], "t": []}, {"i": "EC:2.4.1.99", "l": "\"sucrose:sucrose fructosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9840429", "l": "DELE1(143-515) binds EIF2AK1 (HRI) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64610", "l": "diphosphate + uridylyl-L-threonyl-[protein] => L-threonyl-[protein] + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44253", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21585", "l": "NAD(+) + propane-1,2-diol 1-phosphate => H(+) + hydroxyacetone phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43659", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CTP <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11596", "l": "H(+) + orotidine 5'-phosphate = CO2 + UMP", "d": [], "t": []}, {"i": "EC:4.1.1.23", "l": "\"orotidine-5'-phosphate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73661", "l": "ADP(in) + ATP(out) + H(+)(in) + Mg(2+)(out) => ADP(out) + ATP(in) + H(+)(out) + Mg(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68760", "l": "3 (R)-3-phenyllactate + (R)-lactate + 8 ATP + 4 L-leucine + 4 S-adenosyl-L-methionine = 8 AMP + 8 diphosphate + 8 H(+) + PF1022C + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19018", "l": "(6S)-NADHX + ATP => ADP + H(+) + NADH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036357", "l": "2-phosphoglycerate kinase activity", "d": ["Catalysis of the reaction: 2-phosphoglycerate + ATP = 2,3-diphosphoglycerate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9679044", "l": "FKBP1A binds sirolimus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68611", "l": "Formation of ORC(1-5) complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482897", "l": "PS is hydrolyzed to 2-acyl LPS by PLA2[10] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45895", "l": "an N-acylsphing-4-enine + CDP-ethanolamine <=> an N-acylsphing-4-enine 1-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602399", "l": "PC is hydrolyzed to 1-acyl LPC by PLB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45975", "l": "3-oxochol-4-en-22-oate + H(+) + NADH + O2 <=> 9alpha-hydroxy-3-oxochol-4-en-22-oate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21865", "l": "an S-(2-hydroxyacyl)glutathione + H2O => a 2-hydroxy carboxylate + glutathione + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39108", "l": "(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67278", "l": "2 H(+) + hexanoate + NADH => H2O + hexanal + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6798743", "l": "Exocytosis of secretory granule membrane proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032574", "l": "5'-3' RNA helicase activity", "d": ["Unwinding of an RNA helix in the 5' to 3' direction, driven by ATP hydrolysis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15612", "l": "ATP + D-ribose 5-phosphate <=> 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427514", "l": "eNoSC deacetylates histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396402", "l": "NOTCH1 PEST domain mutants bind promoters of HEY genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191784", "l": "snRNA Cap hypermethylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21640", "l": "NADP(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.13", "l": "\"prephenate dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8932413", "l": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426464", "l": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25106", "l": "ADP + H(+) + pyridoxamine 5'-phosphate => ATP + pyridoxamine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.2.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38206", "l": "19-hydroxyandrost-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 19-oxo-androst-4-ene-3,17-dione + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12978", "l": "H2O + N-phosphocreatine => creatine + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987236", "l": "p-Y705-STAT3 dissociates from  IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57509", "l": "H2O + NADP(+) + staphylopine => (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate + H(+) + NADPH + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51008", "l": "2 Fe(III)-[cytochrome cL] + methanol = 2 Fe(II)-[cytochrome cL] + formaldehyde + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28786", "l": "H2O + L-cysteinylglycine <=> glycine + L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917841", "l": "Acidification of Tf:TfR1 containing endosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008193", "l": "tRNA guanylyltransferase activity", "d": ["Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42806", "l": "7,8-dihydromethanopterin + AH2 => 5,6,7,8-tetrahydromethanopterin + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66772", "l": "ATP + H2O + uroporphyrin I(in) = ADP + H(+) + phosphate + uroporphyrin I(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68477", "l": "a (2R)-2-hydroperoxy fatty acid + H(+) => a fatty aldehyde + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419428", "l": "S1PR2-5 bind S1P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36161", "l": "2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 16 H(+) + 8 reduced 2[4Fe-4S]-[ferredoxin] => 2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55722", "l": "17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + diphosphate => 17-(4-hydroxyphenyl)heptadecanoate + ATP + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-168166", "l": "NF-kappa-B complex is transported from cytosol to nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018718", "l": "1,2-dihydroxy-phenanthrene glycosyltransferase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68116", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol = a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67802", "l": "2 CO2 + 2 formaldehyde + L-lysyl(27)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9034756", "l": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43887", "l": "3-oxochol-4-en-22-oyl-CoA + NAD(+) <=> 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47735", "l": "cytidine(1400) in 16S rRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(1400) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.1", "l": "\"carboxypeptidase A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047265", "l": "poly(glycerol-phosphate) alpha-glucosyltransferase activity", "d": ["Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033438", "l": "ACC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an ACC codon."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22448", "l": "ATP + pseudouridine = ADP + H(+) + psi-UMP", "d": [], "t": []}, {"i": "EC:2.7.1.83", "l": "\"pseudouridine kinase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395849", "l": "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36146", "l": "(2E)-hexadecenoyl-CoA + H(+) + NADPH <=> hexadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54744", "l": "9alpha,11alpha-methylene thromboxane A2 + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-75809", "l": "Phosphorylation of Cdc25C at Ser216 by CHEK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050185", "l": "phosphatidylinositol deacylase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H2O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50313", "l": "2-oxopentanoate + H(+) => butanal + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9656244", "l": "DRD2 binds DA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.17", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653756", "l": "TRIM25 binds monoUb:164-PCNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.78", "l": "\"mannan endo-1,4-beta-mannosidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60422", "l": "[N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine]3 + H(+) => H2O + triglucosyl-enterobactin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10195", "l": "ATP + H2O + sulfate(out) <=> ADP + H(+) + phosphate + sulfate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371435", "l": "Constitutive phosphorylation by GSK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.7", "l": "\"heparin lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-447130", "l": "Interleukin-23 binds interleukin-23 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32701", "l": "beta-sesquiphellandrene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9842651", "l": "Active LTK receptor phosphorylates SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2318623", "l": "Aggrecan binds Hyaluronan and HAPLN1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71067", "l": "L-arginine(in) + L-phenylalanine(out) = L-arginine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3782637", "l": "HDAC8 deacetylates histones (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71046", "l": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022412", "l": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110311", "l": "POLZ extends translesion synthesis (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43536", "l": "2 D-glyceraldehyde 3-phosphate = 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate", "d": [], "t": []}, {"i": "EC:4.2.3.153", "l": "\"(5-formylfuran-3-yl)methyl phosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70596", "l": "a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22357", "l": "diphosphate + oxaloacetate => CO2 + phosphate + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36415", "l": "2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.98", "l": "\"diphthine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8856945", "l": "PP2A methylation by LCMT1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6794346", "l": "NRXNs bind NLGNs (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77466", "l": "furan-3-carbaldehyde + hydrogen cyanide <=> (2S)-2-(furan-3-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77297", "l": "a ganglioside GT3 + CMP + H(+) => a ganglioside GD3 + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654425", "l": "Activated FGFR4 binds SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74217", "l": "L-serine + tRNA(Lys) => H2O + L-seryl-tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71973", "l": "3-hydroxyglutarate(in) + 3 Na(+)(in) => 3-hydroxyglutarate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28673", "l": "2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48952", "l": "14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70900", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate => (2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018798", "l": "RHOV binds GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45591", "l": "a long-chain fatty acid + ATP + holo-[ACP] <=> a long-chain fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018730", "l": "glutaconate CoA-transferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755013", "l": "NME1,2 hexamers phosphorylate RBV-DP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265295", "l": "Prostaglandin E synthase isomerizes PGH2 to PGE2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55763", "l": "a fatty acyl-[ACP] + a lyso-ornithine lipid <=> an N(2)-[(3R)-3-(acyloxy)acyl]-L-ornithine lipid + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51595", "l": "2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene <=> benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20219", "l": "dimethylamine + formaldehyde => H(+) + trimethylamine N-oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191108", "l": "maltose + H2O => 2 D-glucose (sucrase-isomaltase) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36155", "l": "AH2 + Co(II)-factor III + S-adenosyl-L-methionine = A + Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.272", "l": "\"cobalt-factor III methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48828", "l": "H(+) + NADPH + O2 + resorcinol = benzene-1,2,4-triol + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.219", "l": "\"resorcinol 4-hydroxylase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74937", "l": "(3R)-3-isocyanylbutanoate + 3 CO2 + 2 H2O + 2 succinate => (3R)-3-[(carboxymethyl)amino]butanoate + 2 2-oxoglutarate + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-446278", "l": "RhBG mediates ammonium influx into kidney collecting duct cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450092", "l": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201648", "l": "An anchoring protein, Endofin, recruits R-Smad1/5/8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018808", "l": "RAC3 binds effectors at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389826", "l": "glyoxylate + NADPH + H+ => glycolate + NADP+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67098", "l": "CO2 + fumigatonoid A + succinate => 2-oxoglutarate + asnovolin A + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-205262", "l": "Direct recruitment of PI3K to p-KIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6808487", "l": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855747", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-183055", "l": "Binding of CBL to EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0051499", "l": "D-aminoacyl-tRNA deacylase activity", "d": ["Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3640858", "l": "Tankyrase ADP-ribosylates AXIN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53613", "l": "CTP + D-ribulose 5-phosphate + H(+) => CDP-D-ribulose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-481010", "l": "Surface deployment of platelet dense granule membrane components (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53581", "l": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] => 20-hydroxy-14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449200", "l": "Interaction of ABL1 with CDO complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034815", "l": "cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity", "d": ["Catalysis of the reaction: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate = 10-oxabenzo(def)chrysen-9-one + formate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-73718", "l": "UBF-1 Binds rDNA Promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6798749", "l": "Exocytosis of specific granule lumen proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015104", "l": "antimonite transmembrane transporter activity", "d": ["Enables the transfer of antimonite from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.4.4.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45793", "l": "2-oxoglutarate + [ribosomal protein S23]-L-proline + O2 => [ribosomal protein S23]-trans-3-hydroxy-L-proline + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25500", "l": "(2E)-geranyl diphosphate = diphosphate + terpinolene", "d": [], "t": []}, {"i": "EC:4.2.3.113", "l": "\"terpinolene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66928", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51544", "l": "D-ribulose = D-xylulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687126", "l": "p-S215 FOXO3 translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76680", "l": "CoA + NAD(+) + sulfoacetaldehyde => H(+) + NADH + sulfoacetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27548", "l": "3-hydroxyanthranilate + FAD + H(+) + H2O => anthranilate + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008476", "l": "protein-tyrosine sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-374896", "l": "Uptake of Noradrenaline (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782138", "l": "ERCC5 and RPA bind TC-NER site (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9704297", "l": "CHRM2 binds CHRM2 antagonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668714", "l": "RAC1:GTP binds NOX1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76599", "l": "(9Z,12Z)-octadecadienoate + H2O = (12Z)-10-hydroxyoctadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29994", "l": "H(+)(in) + L-lyxopyranose(in) <=> H(+)(out) + L-lyxopyranose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5622134", "l": "CRABP1 binds atRA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52149", "l": "a (Z)-omega-(methylsulfanyl)alkyl-thiohydroximate + UDP-alpha-D-glucose => an aliphatic (Z)-desulfo-glucosinolate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40267", "l": "(3S)-hydroxyhexadecanedioyl-CoA + NAD(+) = 3-oxohexadecanedioyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37506", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9676255", "l": "Formation of the MLL2 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32550", "l": "(2E)-geranyl diphosphate <=> (1R,5R)-sabinene + diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1562640", "l": "LNK binds to p-KIT and inhibit downstream signaling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755304", "l": "MUL1 ubiquitinates UBXN7 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046239", "l": "Extracellular KSPG translocates to the lysosome for degradation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097158", "l": "pre-mRNA intronic pyrimidine-rich binding", "d": ["Binding to a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209355", "l": "Monomeric PGN binds to PGRP-LCx at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446188", "l": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3928625", "l": "PAKs autophosphorylate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110368", "l": "POLD,POLE-mediated DNA strand displacement synthesis (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12515", "l": "D-aspartate + H2O + O2 <=> H2O2 + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17089", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20429", "l": "apigenin + S-adenosyl-L-methionine = acacetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.75", "l": "\"apigenin 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28733", "l": "H(+)(in) + L-leucine(out) => H(+)(out) + L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629149", "l": "NEIL1 cleaves thymine glycol from damaged DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41043", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octanoyl-CoA = 1-O-hexadecyl-2-acetyl-3-octanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72845", "l": "3'-dephospho-CoA(out) + ADP(in) => 3'-dephospho-CoA(in) + ADP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102250", "l": "linear malto-oligosaccharide phosphorylase activity", "d": ["Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047371", "l": "butyrate-acetoacetate CoA-transferase activity", "d": ["Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17187", "l": "GMP + 2 H(+) + NADPH => IMP + NADP(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43045", "l": "hexadecasphinganine + octadecanoyl-CoA => CoA + H(+) + N-octadecanoylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9695949", "l": "SPHK2 phosphorylates sphingoid (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483087", "l": "PI is exchanged with PC by PITPNB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61908", "l": "2 ATP + benzoate + L-phenylalanine + N-benzoyl-L-phenylalaninol = 2 AMP + asperphenamate + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11426", "l": "ADP + H(+) + O-phospho-L-threonyl-[myosin heavy-chain] => ATP + L-threonyl-[myosin heavy-chain]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9014433", "l": "RHOG GEFs activate RHOG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475032", "l": "Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65015", "l": "decanoyl-AMP + holo-[ACP] <=> AMP + decanoyl-[ACP] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2537665", "l": "Fibulin-1 and -2 bind fibronectin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786155", "l": "POLN binds ICL-DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74332", "l": "O-butanoyl-(R)-carnitine(in) => O-butanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71298", "l": "chloride(out) + 2 Na(+)(out) + O-propanoyl-(R)-carnitine(out) <=> chloride(in) + 2 Na(+)(in) + O-propanoyl-(R)-carnitine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70596", "l": "GOT2 dimer deaminates L-Asp (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043760", "l": "acetyldiaminopimelate aminotransferase activity", "d": ["Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61034", "l": "5-hydroxy-3,7,3',4'-tetramethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17263", "l": "a phenol + H(+) + sulfate => an aryl sulfate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985485", "l": "RUNX2 and RB1 bind the BGLAP gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68457", "l": "(S)-3-hydroxyglutaryl-CoA => (2E)-glutaconyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44084", "l": "ATP + CoA + heptadecanoate = AMP + diphosphate + heptadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-164620", "l": "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17526", "l": "biuret + H2O => NH4(+) + urea-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30959", "l": "9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-437243", "l": "Doublecortin binds phosphorylated neurofascin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9853499", "l": "DLD dimer dehydrogenates dihydrolipoyl (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26274", "l": "Co-precorrin-3 + S-adenosyl-L-methionine => Co-precorrin-4 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.42", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8948222", "l": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53741", "l": "[Rab1 protein]-O(4)-(5'-adenylyl)-L-tyrosine + H2O => [Rab1 protein]-L-tyrosine + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19803", "l": "3'-dephospho-CoA + diphosphate => (R)-4'-phosphopantetheine + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75885", "l": "1-acyl LPA is acylated to PA by AGPAT (LPAAT) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76791", "l": "hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 9-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166220", "l": "FA anion diffuses laterally to UCP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-449734", "l": "Acetylation of glucosamine 6-phosphate to GlcNAc6P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9009371", "l": "Binding of AP1 transcriptional activator complexes to CCND1 promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.119", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75366", "l": "thymidine(in) <=> thymidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38076", "l": "2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551616", "l": "SUMOylation of RPA1 (RPA70) with SUMO2,3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380294", "l": "Loss of C-Nap-1 from centrosomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59163", "l": "ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] <=> AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166284", "l": "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9674131", "l": "USP30 binds ATM dimer:Ub-p-PEX5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-174144", "l": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30746", "l": "beta-nicotinamide D-riboside + H2O <=> D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848395", "l": "IL18:IL18R1 binds IL18RAP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5229010", "l": "CARM1 methylates arginine-27 of histone H3 (H3R26) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43380", "l": "H2O + N(omega)-phospho-L-arginyl-[protein] = L-arginyl-[protein] + phosphate", "d": [], "t": []}, {"i": "EC:3.9.1.2", "l": "\"protein arginine phosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034862", "l": "Activated NTRK3 binds SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-964830", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004978", "l": "corticotropin receptor activity", "d": ["Combining with corticotropin to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43136", "l": "guanosine(26)/guanosine(27) in tRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(2)-dimethylguanosine(26)/N(2)-dimethylguanosine(27) in tRNA + 4 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.215", "l": "\"tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26007", "l": "di-trans,nona-cis-dodecaprenyl phosphate + UDP-alpha-D-galacturonate => beta-D-galacturonosyl di-trans,nona-cis-dodecaprenyl phosphate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40546", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19734", "l": "3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) => bacteriochlorophyllide a + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690990", "l": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18670", "l": "adenosine + H2O => adenine + D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73475", "l": "D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13611", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47213", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] => 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853792", "l": "RET tyrosine phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46009", "l": "CoA + NAD(+) + pentanal => H(+) + NADH + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932084", "l": "RUNX1 and ESR1 bind the AXIN1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005484", "l": "SNAP receptor activity", "d": ["Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-202939", "l": "Caspase-mediated cleavage of E-Cadherin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42173", "l": "(11Z)-eicosenoyl-CoA + AH2 + O2 => (8Z,11Z)-eicosadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76951", "l": "H2O + N-methyl-2-methylpropanamine + NAD(+) = 2-methylpropanal + H(+) + methylamine + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12425", "l": "(3S)-3-hydroxy-L-aspartate => NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-372726", "l": "aspartate [mitochondrial matrix] + glutamate [cytosol] <=> aspartate [cytosol] + glutamate [mitochondrial matrix] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40544", "l": "10-deoxymethymycin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => H2O + neomethymycin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66717", "l": "6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate => (2S)-3-sulfolactaldehyde + D-fructose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851866", "l": "MET binds RANBP10 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67495", "l": "a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O <=> a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77742", "l": "a 1,2-diacylglycerol + a glycerophospholipid <=> a 1-acyl-sn-glycero-3-phospholipid + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.199", "l": "\"beta-mannosylphosphodecaprenol--mannooligosaccharide 6-mannosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75730", "l": "(10E,12Z)-octadecadienoate + H2O <=> (10S)-hydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8939335", "l": "RNF181 polyubiquinates BCL10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112152", "l": "RNA Polymerase III Promoter Opening at Type 3 Promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050612", "l": "arsenate reductase (donor) activity", "d": ["Catalysis of the reaction: A + arsenite + H2O = AH(2) + arsenate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47423", "l": "A + glutaryl-CoA <=> (2E)-glutaconyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53626", "l": "diphosphate + tsukubadiene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202726", "l": "F11R dimerises (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0003727", "l": "single-stranded RNA binding", "d": ["Binding to single-stranded RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67934", "l": "ADP + desmosterol(out) + H(+) + phosphate => ATP + desmosterol(in) + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9604308", "l": "NICD4 traffics to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40965", "l": "2 2-aminophenoxazin-3-one + 6 H2O => 4 2-aminophenol + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41596", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19266", "l": "carnitine + NAD(+) => 3-dehydrocarnitine + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55128", "l": "(3R)-hydroxy-5-methylhexanoyl-[ACP] = (2E)-5-methylhexenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46778", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73096", "l": "AMP(out) + CoA(in) => AMP(in) + CoA(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373087", "l": "Receptor CCR6 binds CCL20 ligand (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647746", "l": "EML4 trimerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-482772", "l": "Release of platelet cytosolic components (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701531", "l": "p-Y705,S727 STAT3 is acetylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956050", "l": "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047740", "l": "cephalosporin-C transaminase activity", "d": ["Catalysis of the reaction: (7R)-7-(5-carboxylato-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76062", "l": "heliamine + S-adenosyl-L-methionine <=> H(+) + N-methylheliamine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40330", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700266", "l": "CFTR F508del binds CFTR correctors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51502", "l": "ADP + H(+) + N-acetyl-D-muramate 6-phosphate => ATP + N-acetyl-D-muramate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109863", "l": "Dissociation of p-T,Y-MAPK3:MAP2K1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18193", "l": "H2O + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] = (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21636", "l": "(E)-4-coumarate + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-4-coumarate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.126", "l": "\"hydroxycinnamate 4-beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9700121", "l": "(PTN,MDK):PTPRZ oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-443997", "l": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17426", "l": "CoA + NADP(+) + pyruvate => acetyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2002428", "l": "Removal of fibrillar collagen N-propeptides (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-354077", "l": "Integrin alphaIIb beta3 activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46793", "l": "an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445699", "l": "ATP Hydrolysis By Myosin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63302", "l": "H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine => N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-173745", "l": "Factor D cleaves C3(H2O)-bound Factor B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990081", "l": "trimethylamine receptor activity", "d": ["Combining with the biogenic amine trimethylamine to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948139", "l": "p-S13-FUNDC1 is dephosphorylated by PGAM5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50394", "l": "5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n) => H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + oxytetracycline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848939", "l": "PTK6 binds KHDRBS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63501", "l": "H(+) + NADPH + S-nitrosoglutathione => NADP(+) + sulfinamide glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72095", "l": "Internal Methylation of mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58160", "l": "ent-copalyl diphosphate = diphosphate + dolabradiene", "d": [], "t": []}, {"i": "EC:4.2.3.196", "l": "\"dolabradiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77609", "l": "Binding of APOBEC-1 to form editosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609921", "l": "SGTA binds Tail-anchored protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033851", "l": "lavandulyl diphosphate synthase activity", "d": ["Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0099589", "l": "serotonin receptor activity", "d": ["Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821486", "l": "HCFC1 binds SET1A complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419166", "l": "GEFs activate RhoA,B,C (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68086", "l": "diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] => GTP + L-histidyl-[RNA ligase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482635", "l": "2-acyl LPG is acylated to PG by LPGAT (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050382", "l": "uracil-5-carboxylate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + uracil 5-carboxylate = CO2 + uracil."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51970", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate => (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54376", "l": "(+)-copalyl diphosphate + H2O = diphosphate + nezukol", "d": [], "t": []}, {"i": "EC:4.2.3.183", "l": "\"nezukol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71050", "l": "Trimerization of the FASL:FAS receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45828", "l": "(3R)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52090", "l": "5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.6", "l": "\"coagulation factor Xa\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63589", "l": "prunetin + UDP-alpha-D-glucuronate => prunetin-4'-O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854897", "l": "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27595", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + 5 isopentenyl diphosphate => all-trans-nonaprenyl diphosphate + 5 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60844", "l": "a 5'-end diphospho-guanosine in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6797956", "l": "SLC44A1 transports Cho from cytosol to mitochondrial matrix (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56599", "l": "(1S,4S)-bornane-2,5-dione + FMNH2 + O2 <=> (1S,4S)-5-oxo-1,2-campholide + FMN + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14094", "l": "2-oxoglutarate + L-tryptophan => indole-3-pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47238", "l": "(2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein] => eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31479", "l": "soyasapogenol A + UDP-alpha-D-glucuronate = H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265443", "l": "NPC1L1-mediated cholesterol uptake (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25585", "l": "alpha-L-rhamnose => beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72672", "l": "The 60S subunit joins the translation initiation complex  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34168", "l": "2,6-dihydroxypseudooxynicotine + H2O => 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444416", "l": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13868", "l": "GDP-alpha-D-mannose + N,N'-diacetylchitobiosyl diphosphodolichol <=> beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11691", "l": "ATP + L-leucine + tRNA(Leu) <=> AMP + diphosphate + L-leucyl-tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043906", "l": "Ala-tRNA(Pro) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Ala-tRNA(Pro)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9706308", "l": "Active FLT3 binds to GRB10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.16", "l": "\"ribulokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43482", "l": "1-O-methyl-8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate => 1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807872", "l": "Active ARF recruits coatomer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5205822", "l": "CARM1 methylates arginine-18 (H3R17) of histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955010", "l": "LRTOMT transfers Met to DA, forming 3MT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61260", "l": "H2O + L-glutamine + O2 = 2-oxoglutaramate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0033285", "l": "ATPase-coupled monocarboxylic acid transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9858321", "l": "DHTKD1 dimer decarboxylates 2-OA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59232", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = diphosphate + hydropyrenol", "d": [], "t": []}, {"i": "EC:4.2.3.202", "l": "\"hydropyrenol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20724", "l": "a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54272", "l": "2-oxoglutarate + L-asparaginyl-[ankyrin-repeat domain protein] + O2 = (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654690", "l": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55160", "l": "coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.8.7.3", "l": "\"ferredoxin:CoB-CoM heterodisulfide reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.-", "l": "\"Acid--thiol ligases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24173", "l": "A + a 3-oxo-5beta-steroid => a 3-oxo-Delta(4)-steroid + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48869", "l": "H2O + NADH => AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51868", "l": "dimethylallyl diphosphate + umbelliferone = demethylsuberosin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46373", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (9Z,11E,13E,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851797", "l": "ADRB2 in ADRB2:GRK complex is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168038", "l": "Collagen type XV restin release (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3132737", "l": "MAPKs phosphorylate ETS1 and ETS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5649681", "l": "NEIL2 cleaves 5-OHU from damaged DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51594", "l": "benzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] + toluene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189062", "l": "lactose + H2O => D-glucose + D-galactose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40406", "l": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15171", "l": "L-glutamate + succinate => H2O + N-succinyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6805981", "l": "HMGB1 release from cells (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69608", "l": "Phosphorylation of Cdc25A at Ser-123 by Chk2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8982012", "l": "G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8868659", "l": "Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390673", "l": "CHRM2,4 bind acetylcholine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199558", "l": "KIR2DL1 interacting with HLA-C group 2 (Cw3) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1363274", "l": "Dephosphorylation of p107 (RBL1) by PP2A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5333051", "l": "RPA1 binds HSF1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15980", "l": "(S)-4-hydroxymandelonitrile <=> 4-hydroxybenzaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12706", "l": "[protein]-L-isoaspartate + S-adenosyl-L-methionine => [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9706393", "l": "RHOBTB3 binds ATP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75825", "l": "Proteasome mediated degradation of Cyclin D1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692437", "l": "ANG binds F-actin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201630", "l": "Caspase-mediated cleavage of Acinus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730872", "l": "Activation of Calcineurin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2453876", "l": "TTR:RBP:atROL binds to STRA6 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109701", "l": "PDPK1 binds PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41408", "l": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787623", "l": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102035", "l": "2-methylpropanoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-methylpropanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = (2E)-2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-182993", "l": "Ubiquitination of stimulated EGFR (CBL) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0051087", "l": "protein-folding chaperone binding", "d": ["Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-350901", "l": "Iodide is organified (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.5", "l": "\"galactose-6-sulfurylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66256", "l": "ATP + H(+) + IC-asc-C7 = diphosphate + IC-asc-C7-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70568", "l": "H2O + N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) => 2''-O-tetradecanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15194", "l": "dGTP + H2O => 2'-deoxyguanosine + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67727", "l": "CMP(out) + CMP-N-acetyl-beta-neuraminate(in) <=> CMP(in) + CMP-N-acetyl-beta-neuraminate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71759", "l": "2-oxoglutarate(out) + heptanedioate(in) = 2-oxoglutarate(in) + heptanedioate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5685953", "l": "SIRT6 deacetylates RBBP8 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692437", "l": "ANG binds F-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26487", "l": "H(+) + O-phospho-L-serine + sulfite => L-cysteate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11474", "l": "an L-alpha-amino acid + formaldehyde + H2O2 => an N-methyl-L-amino acid + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60607", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine <=> 1-tetradecanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948219", "l": "PLOD3 binds Lysyl hydroxylated collagen propeptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3788075", "l": "Brevican degradation by ADAMTS4, ADAMTS5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9853369", "l": "PLK1 phosphorylates FIRMM at S744 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2179415", "l": "GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69785", "l": "2-(2-aminophenyl)succinyl-CoA + succinate => (2-aminophenyl)succinate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35929", "l": "3''-deamino-3''-hydroxykanamycin C + H(+) + UDP => paromamine + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015092", "l": "high-affinity ferric iron transmembrane transporter activity", "d": ["Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34604", "l": "15-methylhexadecasphinganine + a fatty acyl-CoA => CoA + H(+) + N-acyl-15-methylhexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1793182", "l": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25475", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + gamma-himachalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33595", "l": "(4R)-hydroxysphinganine + tetracosanoyl-CoA = CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031751", "l": "D4 dopamine receptor binding", "d": ["Binding to a D4 dopamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2025890", "l": "Calcineurin binds NFATC1,2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20692", "l": "chlorogenate + H2O <=> (E)-caffeate + H(+) + L-quinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11736", "l": "2-exo-hydroxy-1,8-cineole + NAD(+) = 6-oxocineole + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.241", "l": "\"6-endo-hydroxycineole dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23118", "l": "4-hydroxybenzoyl-CoA + AMP + diphosphate => 4-hydroxybenzoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46938", "l": "ATP + H(+) + L-2-aminoadipate + NADPH => (S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15530", "l": "bis(2-ethylhexyl)phthalate + H2O => 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685230", "l": "CHEK1 phosphorylates RAD51 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102769", "l": "dihydroceramide glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + a dihydroceramide = UDP + H+ + a D-glucosyl-N-acylsphinganine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839378", "l": "TGFBR3 binding to ARRB1/2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54464", "l": "1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44673", "l": "a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H2O => a 1-acyl-sn-glycero-3-phospho-L-serine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174079", "l": "Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21181", "l": "1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol => D-glucose + indole-3-acetyl-1D-myo-inositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19823", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400097", "l": "G-beta:G-gamma inhibits Adenylate cyclase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191983", "l": "Cholesterol is hydroxylated to 25-hydroxycholesterol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5696448", "l": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654573", "l": "Activated FGFR1 binds SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24995", "l": "L-phenylalanine + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-hydroxy-L-phenylalanine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.15.33", "l": "\"pikromycin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6801766", "l": "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395801", "l": "Phosphorylation of LAT by p-SYK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63652", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18998", "l": "CTP + H(+) + phosphocholine => CDP-choline + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52957", "l": "hyodeoxycholate + UDP-alpha-D-glucuronate => hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701003", "l": "BAP1 binds BRCA1:BARD1 heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25727", "l": "N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5685156", "l": "ATR phosphorylates RPA2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629470", "l": "NEIL3 cleaves 5-guanidinohydantoin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9735775", "l": "Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40553", "l": "H(+) + phylloquinol + S-adenosyl-L-homocysteine => demethylphylloquinol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27340", "l": "2 H(+) + O2 + progesterone + reduced 2[4Fe-4S]-[ferredoxin] <=> 15beta-hydroxyprogesterone + H2O + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31468", "l": "beta-D-glucosyl crocetin + UDP-alpha-D-glucose => bis(beta-D-glucosyl) crocetin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450358", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54601", "l": "2-oxoglutarate + O2 + octanoyl-CoA => 2-hydroxyoctanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20150", "l": "O2 + quinine + reduced [NADPH--hemoprotein reductase] => 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30115", "l": "decanoyl-[ACP] + H2O = decanoate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78410", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + sesterfisherol <=> 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + sesterfisherate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017118", "l": "lipoyltransferase activity", "d": ["Catalysis of the reaction: (R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = (R)-N6-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H+."], "t": []}, {"i": "RHEA:20473", "l": "(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = AMP + 2 H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853429", "l": "PHLDA1 binds AURKA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36629", "l": "CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine => 2-hydroxytetracosanoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12608", "l": "D-glyceraldehyde 3-phosphate + H(+) + pyruvate <=> 1-deoxy-D-xylulose 5-phosphate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72638", "l": "1-hydroxy-6-methoxyphenazine N(10)-oxide + S-adenosyl-L-methionine <=> 1,6-dimethoxyphenazine N(5)-oxide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755757", "l": "SARS-CoV-2 N binds TAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9020256", "l": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58574", "l": "H2O2 + precondylocarpine acetate => O-acetyl-15alpha-stemmadenine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45817", "l": "(S)-lactate + A => AH2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465938", "l": "RBP3 regulates atROL taken up by Muller cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74661", "l": "H(+) + N-acetyl-D-glucosamine 6-phosphate + UDP => N-acetyl-D-glucosamine + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43692", "l": "ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] = AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]", "d": [], "t": []}, {"i": "EC:2.7.11.32", "l": "\"[pyruvate, phosphate dikinase] kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30082", "l": "ATP + CoA + crotonobetaine <=> AMP + crotonobetainyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.707063856546881", "identifiers": [{"i": "GO:1901363", "l": "heterocyclic compound binding", "d": ["Binding to heterocyclic compound."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170671", "l": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426209", "l": "DAG activation of TRPC channels (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209815", "l": "Tyrosine is monoiodinated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34630", "l": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006503", "l": "MECP2 binds the PVALB gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379415", "l": "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004808", "l": "tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity", "d": ["Catalysis of the reaction: 5-aminomethyl-2-thiouridine34 in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine34 in tRNA + H+ + S-adenosyl-L-homocysteine. This enzyme specifically adds the terminal methyl group of 5-[(methylamino)methyl]-2-thiouridylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63127", "l": "H2O + N-octadecanoyl ethanolamine <=> ethanolamine + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22530", "l": "a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside] + H(+) + UDP => a flavonol 3-O-beta-D-glucoside + UDP-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48224", "l": "a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + L-fucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2768999", "l": "NOTCH1 PEST domain mutants bind JAG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106149", "l": "indole-3-carbonyl nitrile 4-hydroxylase activity", "d": ["Catalysis of the reaction: indole-3-carbonyl nitrile + NADPH +O2=4-hydroxyindole-3- carbonyl nitrile + NADP+ + H20."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14916", "l": "AMP + thymidine <=> adenosine + dTMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64482", "l": "(1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate => 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57516", "l": "dolabradiene + O2 + reduced [NADPH--hemoprotein reductase] = 15,16-epoxydolabrene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51604", "l": "2 H(+) + O2 + p-cymene + 2 reduced [2Fe-2S]-[ferredoxin] = 4-isopropylbenzyl alcohol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.25", "l": "\"p-cymene methyl-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58037", "l": "8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) => 8-epi-inunolide + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.39", "l": "\"chymase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47445", "l": "3-oxo-(7Z-hexadecenoyl)-CoA + CoA => (5Z)-tetradecenoyl-CoA + acetyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68804", "l": "H2O + kojibiose = alpha-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74679", "l": "UDP-beta-L-arabinofuranose(in) + UMP(out) = UDP-beta-L-arabinofuranose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190261", "l": "FGFR3c binds to FGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170084", "l": "Formation of Cyclin A:Cdc2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74014", "l": "[(1'E)-3'-hydroxy-3',7'-dimethylocta-1',6'-dien-1'-yl]-quinolinone B + H(+) + NADPH + O2 <=> [(1'E)-5'-(3',3'-dimethyloxiran-2'-yl)-3'-hydroxy-3'-methylpent-1'-en-1'-yl]-quinolinone B + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27719", "l": "H2O + IMP => inosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15265", "l": "1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate", "d": [], "t": []}, {"i": "EC:2.6.99.2", "l": "\"pyridoxine 5'-phosphate synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909755", "l": "Mitochondrial uptake of (R)-3-aminoisobutyric acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "79.323347803118935", "identifiers": [{"i": "GO:1901681", "l": "sulfur compound binding", "d": ["Binding to a sulfur compound."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788867", "l": "FN3K phosphorylates ketosamines (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695890", "l": "SPNS2,MFSD2B transport S1P from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33522", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + sphinganine <=> (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30341", "l": "CO2 + tryptamine => H(+) + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-173597", "l": "UDP-glucose is oxidised to UDP-glucuronate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672972", "l": "MAP2Ks and MAPKs bind to the activated RAF complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11608", "l": "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + n acetyl-CoA = [N,O(9)-diacetyl-alpha-D-neuraminosyl-(2->8)](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654640", "l": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20542", "l": "H(+) + Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 => 2 H2O + Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901515", "l": "poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity", "d": ["Enables the transfer of poly-beta-1,6-N-acetyl-D-glucosamine from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14884", "l": "3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) <=> asparagusate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67892", "l": "3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine = 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607023", "l": "factor IXa associates with cell membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12785", "l": "an alditol + NAD(+) = an aldose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56201", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-alpha-D-galactose => H(+) + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692754", "l": "CDC14A,B dephosphorylate p-3S,T MAPK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5693620", "l": "D-loop formation mediated by PALB2, BRCA2 and RAD51 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855222", "l": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24414", "l": "4-formylbenzenesulfonate + H(+) + NADH => 4-(hydroxymethyl)benzenesulfonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55787", "l": "all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate <=> all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26395", "l": "2 (3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => all-trans-zeaxanthin + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9839363", "l": "TGFBR3 phosphorylation by TGFBR2 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5692775", "l": "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9610627", "l": "KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15979", "l": "4-hydroxybenzaldehyde + hydrogen cyanide => (S)-4-hydroxymandelonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48810", "l": "(5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109903", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9820566", "l": "ZnT5 transports zinc into the golgi apparatus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914012", "l": "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43555", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71733", "l": "citrate(in) + tartrate(out) => citrate(out) + tartrate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36891", "l": "(9Z,12Z)-octadecadienoyl-CoA + AH2 + O2 = (9Z,12Z,15Z)-octadecatrienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61953", "l": "2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + N(6),N(6)-dimethyl-L-lysyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18478", "l": "2,3-dihydroxybenzoate + O2 => 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74404", "l": "2 (S)-lactate(in) + prostaglandin D2(out) => 2 (S)-lactate(out) + prostaglandin D2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33606", "l": "H(+) + N-hexacosanoylsphinganine + NADPH + O2 <=> H2O + N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59340", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene + A = 1'-hydroxy-demethylspheroidene + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26337", "l": "L-homocysteine + S-methyl-L-methionine = H(+) + 2 L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786720", "l": "DECR2 reduces LCtE-CoA to t3enoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654615", "l": "Activated FGFR2:pFRS binds GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6794346", "l": "NRXNs bind NLGNs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165162", "l": "Phosphorylation of TSC2 by PKB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70223", "l": "(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061632", "l": "RNA lariat debranching enzyme activator activity", "d": ["Binds to and increases the activity of an RNA lariat debranching enzyme."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11540", "l": "an N-acyl-D-mannosamine + NAD(+) = an N-acyl-D-mannosaminolactone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.233", "l": "\"N-acylmannosamine 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26318", "l": "2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate => 3-amino-4-hydroxybenzoate + H(+) + 2 H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33811", "l": "3 2,3-dihydroxybenzoate + 6 ATP + 3 glycine + 3 L-threonine = 6 AMP + corynebactin + 6 diphosphate + 3 H(+) + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3781943", "l": "WLS:WNT complex is internalized for maturation into exosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003851", "l": "N-acylsphingosine galactosyltransferase", "d": ["Catalysis of the reaction: N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28330", "l": "H2O + ITP = H(+) + IDP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4093329", "l": "EFNBs bind SDCBP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8865994", "l": "GAB1 binds PTPN11 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56377", "l": "3-bromo-4,5-dihydroxybenzoate + bromide + 3 H(+) + NADPH + O2 => 3,5-dibromobenzene-1,2-diol + CO2 + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21257", "l": "3-phosphoshikimate + phosphoenolpyruvate => 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446191", "l": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-909552", "l": "Phosphorylation of STAT1 at Ser727 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0008381", "l": "mechanosensitive monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress."], "t": []}, {"i": "TCDB:1.A.23.2.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23166", "l": "a flavonol 7-O-beta-D-glucoside + H(+) + UDP => a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-399950", "l": "Phosphorylation of cofilin by LIMK-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33118", "l": "malonate(in) <=> malonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5694137", "l": "PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018592", "l": "4-nitrocatechol 4-monooxygenase activity", "d": ["Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9033499", "l": "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193995", "l": "CYP11B2 18-hydroxylates CORST to 18HCORST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373745", "l": "SDK1 homophillic interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0034040", "l": "ATPase-coupled lipid transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2162002", "l": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102470", "l": "6C-naringenin dibenzoylmethane tautomer glucosyltransferase activity", "d": ["Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose = 6C-glucosyl-2-hydroxynaringenin + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32579", "l": "(2E)-geranyl diphosphate = (1R,5R)-beta-pinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.122", "l": "\"(+)-beta-pinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374787", "l": "GPCR neuropeptide receptor binds neuropeptides B and W (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-265166", "l": "Exocytosis of Insulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77892", "l": "H2O + N(2)-(1-deoxy-beta-D-fructopyranos-1-yl)-L-lysine + O2 => (1-deoxy-D-fructos-1-yl)amine + 6-amino-2-oxohexanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-165195", "l": "GTP loading by Rheb (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8873834", "l": "STARD10 transports PC from ER membrane to lamellar body membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14727", "l": "2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate => 2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33431", "l": "(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate", "d": [], "t": []}, {"i": "EC:5.3.2.6", "l": "\"2-hydroxymuconate tautomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295613", "l": "SPRY2 binds GRB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193845", "l": "CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654600", "l": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21050", "l": "ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate => ATP + isopropylamine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38442", "l": "(9Z)-octadecenoyl-CoA + 2,3-di-(9Z)-octadecenoyl-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49034", "l": "4'-demethylepipodophyllotoxin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (-)-4'-desmethyl-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140818", "l": "mRNA 5'-triphosphate monophosphatase activity", "d": ["A 5'-end triphospho-[mRNA] + H2O = a 5'-end diphospho-[mRNA] + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13924", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] <=> gibberellin A12 aldehyde + 3 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420489", "l": "Parathyroid hormone receptor can bind parathyroid hormone (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67222", "l": "(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + H(+) + NADH => (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1676133", "l": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429749", "l": "SLC5A8 transports monocarboxylates from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610152", "l": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9731924", "l": "EDNRA binds EDNs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51690", "l": "H(+) + keto-L-tagatose + NADH => galactitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14033", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol = 1D-myo-inositol 1-phosphate + glycerol + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.43", "l": "\"glycerophosphoinositol inositolphosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74036", "l": "D-serine(out) + L-alanine(in) => D-serine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139909", "l": "Translocation of BMF to mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-174227", "l": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15105", "l": "kaempferol + S-adenosyl-L-methionine = H(+) + kaempferide + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.155", "l": "\"kaempferol 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16510", "l": "H(+) + oxalate => CO2 + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3296244", "l": "SUCNR1 binds SUCCA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928578", "l": "EPH receptors autophosphorylate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11277", "l": "4 hydroquinone + O2 => 4 benzosemiquinone + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2028644", "l": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68525", "l": "(2Z,6Z)-farnesyl diphosphate => beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30274", "l": "2 (3,4-dimethoxyphenyl)methanol + H2O2 <=> 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917933", "l": "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53097", "l": "4-hydroxy-17beta-estradiol + S-adenosyl-L-methionine => 4-methoxy-17beta-estradiol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78849", "l": "a very-long-chain (2E)-enoyl-CoA + H2O2 => a very-long-chain 2,3-saturated fatty acyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71596", "l": "2-oxoglutarate(out) + succinate(in) => 2-oxoglutarate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78451", "l": "a globoside Gb3Cer + H2O = a fatty acid + a lysoGb3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-437139", "l": "ZnT8 transports zinc into the Golgi apparatus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76717", "l": "(17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75157", "l": "diphosphate + verrucosan-2beta-ol => (2E,6E,10E)-geranylgeranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48689", "l": "H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine => D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17553", "l": "ATP + guanidinoethyl methyl phosphate = ADP + H(+) + N'-phosphoguanidinoethyl methylphosphate", "d": [], "t": []}, {"i": "EC:2.7.3.7", "l": "\"opheline kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9796053", "l": "PRKCI phosphorylates NFE2L2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203613", "l": "depalmitoylation of eNOS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8849908", "l": "SALM4 binds flotillin-1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426263", "l": "Dystroglycan binds NRXN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42747", "l": "guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47320", "l": "(S)-3-amino-3-phenylpropanoate + 2-oxoglutarate = 3-oxo-3-phenylpropanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58167", "l": "(2E,6E)-farnesyl diphosphate + 2 H2O <=> 7-epi-ent-eudesmane-5,11-diol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69911", "l": "adenosine(out) + 2 Na(+)(out) = adenosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1497855", "l": "Ascorbate can reduce the BH3 radical back to BH4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944240", "l": "Association of procollagen type III (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3209165", "l": "ID1 sequesters ETS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27950", "l": "L-phenylalanine(in) = L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5683888", "l": "LMCD1 binds GATA6, sequestering it (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140320", "l": "PAMP receptor decoy activity", "d": ["Binding and sequestering PAMP ligands in order to prevent them from binding and activating to the host PAMP receptor. Usually this activity is encoded by a symbiont or a pathogen to prevent activation of the host innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-444433", "l": "Cho transports from the extracellular space to the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952638", "l": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16248", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106157", "l": "peptidyl-arginine 3-dioxygenase activity", "d": ["Catalyzes the reaction: 2-oxoglutarate + [protein]-L-arginine + O2 = [protein]-(3R)-3-hydroxy-L-arginine + CO2 + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5216234", "l": "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73840", "l": "ATP + H2O + phenol => AMP + 2 H(+) + phenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77060", "l": "3-methylcyclopentanamine + H2O + NADP(+) => 3-methylcyclopentanone + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008822", "l": "PPM1D dephosphorylates RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74746", "l": "GRB2-1:SOS1 binds p-Y427-SHC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12317", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5638332", "l": "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48309", "l": "2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O => (3Z)-6-oxohex-3-enoyl-CoA + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56912", "l": "(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + H2O + NAD(+) = (E)-2-((N-methylformamido) methylene)succinate + 3 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78854", "l": "a long-chain 2,3-saturated fatty acyl-CoA + O2 <=> a long-chain (2E)-enoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8953013", "l": "E2F7 binds E2F8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42541", "l": "uridine(13) in tRNA => pseudouridine(13) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20817", "l": "3alpha-hydroxyglycyrrhetinate + NADP(+) => 3-oxoglycyrrhetinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56983", "l": "4-hydroxybenzyl alcohol + 2 oxidized [azurin] <=> 4-hydroxybenzaldehyde + 2 H(+) + 2 reduced [azurin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9815510", "l": "MIB2 binds CYLD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0043121", "l": "neurotrophin binding", "d": ["Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48747", "l": "(-)-yatein + 2-oxoglutarate + O2 <=> (-)-deoxypodophyllotoxin + CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70420", "l": "HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201611", "l": "Caspase-mediated cleavage of Rock-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102679", "l": "(5alpha)-campestan-3-one hydroxylase activity", "d": ["Catalysis of the reaction: H+ + (5alpha)-campestan-3-one + O2 + NADPH = (5alpha,22S,24R)-22-hydroxyergostan-3-one + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928604", "l": "SFKs phosphorylate VAV2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0004410", "l": "homocitrate synthase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H2O = CoA + H+ + homocitrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2466106", "l": "BGN binds Collagen types I, VI, (IX) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38994", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-dodecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203977", "l": "SAR1 Activation And Membrane Binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-264678", "l": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32921", "l": "(indol-3-yl)acetate + H(+) + methanol => H2O + methyl (indol-3-yl)acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033922", "l": "peptidoglycan beta-N-acetylmuramidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing N-acetylmuramic residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9650858", "l": "Meglitinides bind ABCC8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013361", "l": "NEXT3 is cleaved to produce NICD3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-981539", "l": "C3b binds to cell surface (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72180", "l": "Cleavage of mRNA at the 3'-end (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1855194", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71510", "l": "(+)-alpha-tocopherol(out) <=> (+)-alpha-tocopherol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14043", "l": "mandelonitrile + vicianose => (R)-vicianin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1475436", "l": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551738", "l": "SUMOylation of TDG with SUMO2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14670", "l": "D-glyceraldehyde 3-phosphate + H2O + NADP(+) => (2R)-3-phosphoglycerate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809254", "l": "MTMR8 binds MTMR9 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786101", "l": "IL4 binds IL4R:JAK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60486", "l": "cyclic CMP-UMP + 2 diphosphate => CTP + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32613", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (6E)-8-hydroxygeranial + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982018", "l": "G alpha (z):RGS complex dissociates to give inactive G alpha (z) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-350567", "l": "Antizyme OAZ binds to Ornithine decarboxylase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106137", "l": "IkappaB kinase complex binding", "d": ["Binding to a IkappaB kinase complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76357", "l": "n H(+)(in) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(in) => n H(+)(out) + N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate-D-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13941", "l": "ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.28", "l": "\"triokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66980", "l": "2-methylbutanoyl-CoA + H2O = 2-methylbutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9696179", "l": "IFNAR2:JAK1:STAT2 binds type 1 interferon analogs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031809", "l": "H3 histamine receptor binding", "d": ["Binding to a H3 histamine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110221", "l": "Cleavage of uracil by SMUG1 glycosylase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71418", "l": "3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in) <=> 3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938951", "l": "RUNX1 binds PAX5 (BSAP) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9834821", "l": "p-PRKRA dimer binds PKR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73303", "l": "H(+)(in) + oxaloacetate(out) + phosphate(in) = H(+)(out) + oxaloacetate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0005096", "l": "GTPase activator activity", "d": ["Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709547", "l": "ESTG binds ESR2:chaperone complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-879907", "l": "Tyrosine kinases phosphorylate the receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25980", "l": "(5S)-albaflavenol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = albaflavenone + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8876312", "l": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70664", "l": "4-hydroxy-L-proline(in) + H(+)(in) => 4-hydroxy-L-proline(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190519", "l": "Internalization of gap junction plaques (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15778", "l": "1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O => 1-guanidino-1-deoxy-scyllo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75795", "l": "Na(+)(out) + nicotinate(out) = Na(+)(in) + nicotinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46063", "l": "(11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39743", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866321", "l": "VLDL binds APOC1 and APOC4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592297", "l": "Full activation of MMP1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65592", "l": "8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] = 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418918", "l": "The UDP/CysLT (P2Y17) receptor can bind UTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38774", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428750", "l": "Gq activation by TP receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52671", "l": "[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + NADP(+) + phosphate <=> [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9604308", "l": "NICD4 traffics to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6813749", "l": "ALDH1A1 oxidises GA to DGA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11006", "l": "catechol + CO2 + H2O + NAD(+) => 2 H(+) + NADH + O2 + salicylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75822", "l": "(5Z,8Z)-octadecadienoate + O2 <=> (5S)-hydroperoxy-(6E,8Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9766656", "l": "RBX1:CUL3 dissociates from forming autophagosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371422", "l": "ATP hydrolysis by HSP70 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60697", "l": "(R)-lavandulyl diphosphate + H2O => (R)-lavandulol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8956184", "l": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788628", "l": "p-Y-STATs dissociate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8959510", "l": "SEPHS2 phosphorylates H2Se to form SELP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45677", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13303", "l": "a 1-acyl-sn-glycerol + a sterol ester => a 1,2-diacyl-sn-glycerol + a sterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210837", "l": "HNF6-dependent synthesis of ONECUT3 protein during morphogenesis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8948224", "l": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482545", "l": "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018447", "l": "chloral hydrate dehydrogenase activity", "d": ["Catalysis of the reactions: chloral hydrate = 3 H+ + 2 e- + trichloroacetate, and chloral hydrate + H2 = H2O + trichloroethanol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759461", "l": "ABCB1 transports PREDN,PREDL out of hepatic cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428273", "l": "SPHK1 phosphorylates sphingoid (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875576", "l": "CRK,CRKL recruits RAC1 GEF to activated MET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5244424", "l": "botA:SV2:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6810464", "l": "NUDT14 hydrolyses UDP-Glc to G1P and UMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26455", "l": "NADP(+) + propanoyl-CoA => acryloyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9634834", "l": "ACHEIs bind ACHE (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0016727", "l": "oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule."], "t": []}, {"i": "EC:1.17.3.-", "l": "\"With oxygen as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24046", "l": "4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => 3,4-dihydroxybenzoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5666104", "l": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170088", "l": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3095901", "l": "ABCC1 transports cytosolic RCbl to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77511", "l": "2-methoxybenzaldehyde + hydrogen cyanide = (2S)-2-hydroxy-2-(2-methoxyphenyl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804762", "l": "TP53 forms homotetramers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52913", "l": "3-dimethylallyl-4-hydroxymandelate + O2 => 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70569", "l": "arginine + H2O => ornithine + urea [ARG1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60687", "l": "(11R)-dihydroartemisinic aldehyde + H2O + NADP(+) <=> (11R)-dihydroartemisinate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444433", "l": "Cho transports from the extracellular space to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10431", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67081", "l": "a very long-chain fatty acid(in) + ATP + H2O => a very long-chain fatty acid(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050600", "l": "acyl-CoA 11-(E)-desaturase activity", "d": ["Catalysis of the reaction: an 11,12-saturated fatty acyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an (11E)-delta11-fatty acyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53538", "l": "(13R,14S)-dihydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate => (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49835", "l": "a fatty aldehyde + H2O + NAD(+) <=> a fatty acid + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173740", "l": "Factor B binds to C3(H2O) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72671", "l": "eIF5B:GTP is hydrolyzed and released (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9755035", "l": "SLC29A1 transports RBV from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432946", "l": "PARVB/Affixin interacts with alpha PIX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6803227", "l": "Dissociation of high activity BRAF complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-434381", "l": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4546387", "l": "PIAS4 SUMOylates VDR with SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43986", "l": "(2E,6E)-omega-hydroxy-farnesol + H2O + NADP(+) => (2E,6E)-farnesol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67417", "l": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] => (1R,6S)-isopiperitenol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177943", "l": "GRB2:SOS1 complex binds to EGF:EGFR complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139898", "l": "Caspase-8 activates BID by cleavage (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73548", "l": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3322422", "l": "Beta-catenin recruits SMARCA4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73671", "l": "ADP(out) + diphosphate(in) = ADP(in) + diphosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-741411", "l": "CYLD deubiquitinates NEMO (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218850", "l": "VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.76", "l": "\"deoxyadenosine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8875482", "l": "CBL recruits CIN85:endophilin to ubiquitinated MET (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66939", "l": "(E)-caffeoyl-CoA + 5-hydroxyanthranilate <=> avenanthramide C + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043780", "l": "cobalt-precorrin-5B C1-methyltransferase activity", "d": ["Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985594", "l": "MYO9B inactivates RHOA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45524", "l": "phycocyanobilin-L-cysteinyl(84)-[C-phycocyanin alpha-subunit] = (2R,3E)-phycocyanobilin + apo-L-cysteinyl(84)-[C-phycocyanin alpha-subunit]", "d": [], "t": []}, {"i": "EC:4.4.1.32", "l": "\"C-phycocyanin alpha-cysteine-84 phycocyanobilin lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170153", "l": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956568", "l": "RUNX1 binds the core TAL1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981353", "l": "RASA1 stimulates RAS GTPase activity (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730861", "l": "Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2032396", "l": "Dimerized phospho-IRF3 migrates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37108", "l": "H2O + N(7)-methyl-GMP => N(7)-methylguanosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4093342", "l": "SDC2 multimerises (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13047", "l": "ent-kaur-16-en-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-ene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759172", "l": "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.216", "l": "\"farnesol kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102758", "l": "very-long-chain enoyl-CoA reductase activity", "d": ["Catalysis of the reaction: a very-long-chain 2,3-saturated fatty acyl-CoA + NADP+ = a very-long-chain (2E)-enoyl-CoA + H+ + NADPH. This reaction is the fourth (reduction) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21574", "l": "CO + H(+) + N-acetylanthranilate => 3-hydroxy-2-methyl-1H-quinolin-4-one + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196372", "l": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662986", "l": "MT2A binds copper (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17723", "l": "a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein] => a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52299", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58083", "l": "1-docosanoylglycerol + H2O <=> docosanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102433", "l": "phenylalanine 4-hydroxylase (N10-formyl-tetrahydrofolate dependent) activity", "d": ["Catalysis of the reaction: L-phenylalanine + O2 + an N10-formyl-tetrahydrofolate = L-tyrosine + a 10-formyltetrahydrofolate-4a-carbinolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28992", "l": "N-acetylneuraminate(in) => N-acetylneuraminate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983876", "l": "STAT4 binds IL12RB2:IL12RB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59595", "l": "ATP + beta-alanine + L-arginine <=> ADP + beta-alanyl-L-arginine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44931", "l": "2-oxoheptanedioate + acetyl-CoA + H2O <=> (R)-trihomocitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2250301", "l": "Formation of lysyl-pyrrole cross-links (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68954", "l": "Mcm2-7 is phosphorylated by DDK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15103", "l": "CO2 + L-lysine => H(+) + meso-2,6-diaminoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20952", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose = beta-D-glucosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.188", "l": "\"N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684801", "l": "p-Y7-CLEC1B dimer:PDPN binds SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209944", "l": "25(OH)D binds GC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49406", "l": "alpha-D-mannose 1-phosphate + D-mannose => beta-D-mannopyranosyl-(1->2)-D-mannopyranose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004026", "l": "alcohol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007640", "l": "RBBP4 gene expression is inhibited by E2F6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59899", "l": "ATP + L-glutamate + L-propargylglycine <=> ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72218", "l": "2 hydrogencarbonate(out) + Na(+)(out) <=> 2 hydrogencarbonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3465545", "l": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55854", "l": "[(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA => [(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47032", "l": "AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]", "d": [], "t": []}, {"i": "EC:2.8.1.13", "l": "\"tRNA-uridine 2-sulfurtransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043250", "l": "sodium-dependent organic anion transmembrane transporter activity", "d": ["Enables the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72621", "l": "Ribosomal scanning  (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9718360", "l": "GNRHR binds GNRHR peptide agonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58239", "l": "L-tyrosyl-[protein] + NAD(+) <=> H(+) + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40709", "l": "1-O-(9Z,12Z,15Z)-octadecatrienylglycerone 3-phosphate + H(+) + hexadecanoate => (9Z,12Z,15Z)-octadecatrien-1-ol + 1-hexadecanoylglycerone 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18781", "l": "H(+) + malonyl-CoA = acetyl-CoA + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.9", "l": "\"malonyl-CoA decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851899", "l": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21543", "l": "N-(5-phospho-beta-D-ribosyl)anthranilate <=> 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9855212", "l": "SDHA binds to SDHB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8982667", "l": "PGM2:Mg2+ isomerises  dR1P to dR5P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-190408", "l": "Autocatalytic phosphorylation of FGFR2b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.141", "l": "\"4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4420099", "l": "p-6Y-VEGFR2 binds SHB  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69396", "l": "a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045735", "l": "nutrient reservoir activity", "d": ["Functions in the storage of nutritious substrates."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68954", "l": "Mcm2-7 is phosphorylated by DDK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-984606", "l": "Kinesin-5 is a homotetramer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19325", "l": "H(+) + NADH + O2 + quinolin-4-ol = H2O + NAD(+) + quinoline-3,4-diol", "d": [], "t": []}, {"i": "EC:1.14.13.62", "l": "\"4-hydroxyquinoline 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74946", "l": "2-oxoglutarate + a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + O2 <=> a (3R)-3-isocyanyl-fatty acid + 2 CO2 + 2 H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689111", "l": "PARK2 autoubiquitinates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811415", "l": "RAB:GTP recruits GBF1 to the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35158", "l": "(S)-4,5-dihydroxypentane-2,3-dione <=> (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928614", "l": "EFNB:GRB4 binds GIT1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41588", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43256", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9673054", "l": "PM20D1 hydrolyzes oleoyl-phe (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70135", "l": "6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55327", "l": "11-cis-retinol + hexadecanoyl-CoA <=> 11-cis-retinyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936895", "l": "ATP7B transports cytosolic Cu2+ to Golgi lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30233", "l": "(2E,6E)-farnesal + H2O2 + L-cysteine => H2O + O2 + S-(2E,6E)-farnesyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448591", "l": "Interleukin-32 binds proteinase-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.17.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-549385", "l": "CRY:PER:Kinase complex translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33987", "l": "(+)-copalyl diphosphate = diphosphate + neoabietadiene", "d": [], "t": []}, {"i": "EC:4.2.3.132", "l": "\"neoabietadiene synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42130", "l": "a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-sphinganine-1-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33420", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA => [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64830", "l": "3-hydroxy-benzyl acetate + CoA => 3-hydroxybenzyl alcohol + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:1901375", "l": "acetate ester transmembrane transporter activity", "d": ["Enables the transfer of an acetate ester from one side of a membrane to the other."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34212", "l": "ecgonine methyl ester + NADP(+) => ecgonone methyl ester + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18347", "l": "a cis-alkene + CO2 => a cis-3-alkyl-4-alkyloxetan-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42422", "l": "(4R)-4-hydroxy-L-lysine + CO2 + succinate => 2-oxoglutarate + L-lysine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013157", "l": "CDC42 binds effectors at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44424", "l": "a fatty acyl-CoA + heptadecasphing-4-enine = CoA + H(+) + N-acyl-heptadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390281", "l": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420586", "l": "Necl-1:Necl-2 trans heterodimer interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.99.-", "l": "\"Transferring other glycosyl groups\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983307", "l": "IL15 binds IL15RA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9724753", "l": "PLG(20-810) binds anti-fibrinolytics (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74552", "l": "H2O + L-seryl-tRNA(Ser) => L-serine + tRNA(Ser)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11101", "l": "4-hydroxyhexan-3-one => 2 propanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74951", "l": "(3R)-3-{[carboxy(hydroxy)methyl]amino}butanoate + 2-oxoglutarate + O2 = (3R)-3-isocyanylbutanoate + 2 CO2 + 2 H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75582", "l": "A + cyathatriol <=> AH2 + cyathin A3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2029469", "l": "p-ERK phosphorylates WAVEs and ABI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58184", "l": "H(+) + NADPH + 2 phytyl diphosphate = (14E,18E)-lycopadiene + 2 diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004838", "l": "L-tyrosine:2-oxoglutarate aminotransferase activity", "d": ["Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9646348", "l": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047667", "l": "AMP-thymidine kinase activity", "d": ["Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21871", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4341072", "l": "SUMOylation of RARA with SUMO2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661799", "l": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12002", "l": "CO2 + NADPH => formate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-193679", "l": "alpha-secretase cleaves the p75NTR extracellular domain (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109864", "l": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52982", "l": "7-oxoheptanoyl-[ACP] + a fatty aldehyde + H(+) + 2 H2O + oxidized [flavodoxin] => a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-381262", "l": "Formation of PPARG:RXRA heterodimer (ARF6 complex) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46797", "l": "an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33307", "l": "(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] = (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.195", "l": "\"protein-N(pi)-phosphohistidine--2-O-alpha-mannosyl-D-glycerate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19910", "l": "(S)-lactate + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40557", "l": "dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + 3 H2O + 2 NADP(+) => dTDP-beta-L-evernosamine + H(+) + 2 NADPH + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69533", "l": "(2S)-2-amino-4-deoxychorismate => 4-amino-4-deoxychorismate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36371", "l": "(2S)-hydroxybutanoate + NAD(+) = 2-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78034", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol <=> a 1,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203979", "l": "Coat Assembly (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6806967", "l": "CARKD dehydrates S-NAD(P)HX to NADPH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8875183", "l": "CBL monoubiquitinates activated MET (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6791016", "l": "SFTPB binds itself (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210277", "l": "Interaction of PECAM-1 and SHP-1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45045", "l": "2 Fe(II)-[cytochrome c] + H(+) + nitroxyl + O2 => 2 Fe(III)-[cytochrome c] + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0004557", "l": "alpha-galactosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759358", "l": "NFE2L2-dependent SRXN1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211874", "l": "CYP2S1 4-hydroxylates atRA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57724", "l": "H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate", "d": [], "t": []}, {"i": "EC:7.2.4.2", "l": "\"oxaloacetate decarboxylase (Na(+) extruding)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49600", "l": "ATP + CoA + octanedioate = AMP + diphosphate + octanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177945", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34824", "l": "(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O => CO2 + 2 CoA + curcumin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17402", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate => 4-carboxy-2-hydroxy-cis,cis-muconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864125", "l": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62749", "l": "H2O + lovastatin => (S)-2-methylbutanoate + H(+) + monacolin J", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11790", "l": "H(+) + NADH + NH4(+) + oxaloacetate => H2O + L-aspartate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-201510", "l": "PI3K synthesizes PIP3 downstream of ALK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28498", "l": "formaldehyde + mycothiol = S-(hydroxymethyl)mycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2545203", "l": "Deacetylation of cleaved cohesin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-917814", "l": "apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8853755", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855166", "l": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395223", "l": "Formation of hydroxylysyl-pyridinoline cross-links (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814153", "l": "ADO oxidises 2AET to HTAU (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45386", "l": "(9Z)-octadecenoate + H(+) + N-hexadecanoyl-sn-glycero-3-phosphoethanolamine => H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9840807", "l": "OPTN binds ATG9A (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9756138", "l": "CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686578", "l": "Activated ATM phosphorylates ABL1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788571", "l": "STAT1,STAT3,STAT6 bind IL13:IL13R type II (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097269", "l": "all-trans-decaprenyl-diphosphate synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6788810", "l": "AK6 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44772", "l": "2-methoxy-6-(all-trans-hexaprenyl)phenol + H(+) + NADPH + O2 = 2-methoxy-6-all-trans-hexaprenyl-1,4-benzoquinol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45051", "l": "acetamide + H2O <=> acetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0008251", "l": "tRNA-specific adenosine deaminase activity", "d": ["Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45572", "l": "[(1->4)-beta-D-mannuronosyl](n) = [alginate](n)", "d": [], "t": []}, {"i": "EC:5.1.3.37", "l": "\"mannuronan 5-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-429441", "l": "SYK activation by SRC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-561072", "l": "OCT3 mediates renal uptake of organic cations (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46147", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24R)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4086083", "l": "SUMOylation of ING2 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651773", "l": "LIG1 binds POLB at long-patch BER site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141159", "l": "TNF-mediated dimerization of procaspase-8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-373707", "l": "Netrin-1 induced DCC clustering (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9696267", "l": "RND3 binds GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-163809", "l": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57451", "l": "ATP + D-tyrosine + tRNA(Tyr) <=> AMP + D-tyrosyl-tRNA(Tyr) + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8932221", "l": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43781", "l": "2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9836702", "l": "PKR inhibitors bind PKR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176879", "l": "apolipoprotein(a) + LDL => Lp(a) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11908", "l": "H2O + nonane-4,6-dione = butanoate + H(+) + pentan-2-one", "d": [], "t": []}, {"i": "EC:3.7.1.7", "l": "\"beta-diketone hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8986972", "l": "IL24 binds IL20RA:JAK1:IL20RB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69666", "l": "H2O + luteolin 7-O-beta-D-glucoside <=> beta-D-glucose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5263616", "l": "MeSeO2H is reduced to MeSeOH by TXNRD1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13195", "l": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate => 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205661", "l": "Pink1 is recruited from the cytoplasm to the mitochondria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111879", "l": "PIP2 hydrolysis (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23395", "l": "(n-1) H2O + RNA(n) <=> n a ribonucleoside 5'-phosphate + n H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43487", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64840", "l": "2-phenylethanol + benzoyl-CoA = CoA + phenethyl benzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814096", "l": "ARL1:GTP binds SCOC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102787", "l": "caffeoyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-beta-D-caffeoylglucoside + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12894", "l": "prostaglandin H2 => prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9718020", "l": "PTGFR binds PTGFR agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48702", "l": "a fatty acid + H(+) + long chain acyl-3-O-beta-D-galactosyl-sn-glycerol => H2O + long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43544", "l": "ATP + L-glutamate + tyramine = ADP + gamma-L-glutamyltyramine + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.24", "l": "\"tyramine--L-glutamate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9829047", "l": "F0 is palmitoylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47950", "l": "phosphate + thiamine => H2O + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75197", "l": "5-hydroxy-2,4-dioxopentanoate + H(+) + NADH => 2-dehydro-3-deoxy-D-arabinonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653592", "l": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450296", "l": "Phosphorylated MKK3/MKK6 migrates to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019911", "l": "structural constituent of myelin sheath", "d": ["The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-427570", "l": "Group 3 - Selective Cl- transport (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222644", "l": "TrxA/B1 reactivates Tpx (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009885", "l": "transmembrane histidine kinase cytokinin receptor activity", "d": ["Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13497", "l": "5-dehydro-2-deoxy-D-gluconate + ATP = 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.92", "l": "\"5-dehydro-2-deoxygluconokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797100", "l": "CCNK binds CDK13 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14814", "l": "L-2-aminohexano-6-lactam => D-2-aminohexano-6-lactam", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56211", "l": "CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] <=> 3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34937", "l": "diphosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate => 2 ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043873", "l": "pyruvate-flavodoxin oxidoreductase activity", "d": ["Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592349", "l": "MMP14 (MT1-MMP) binds TIMP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32033", "l": "diphosphate + gamma-curcumene => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-420123", "l": "Glucagon-like receptor 2 binds GLP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20144", "l": "an S-alkyl-L-cysteine S-oxide <=> 2-aminoprop-2-enoate + an S-alkyl sulfenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141094", "l": "DNA loop anchor binding", "d": ["Binding to a DNA loop anchor, a region of chromosome that defines the ends of a DNA loop where two parts of same DNA strand are held in close physical proximity. For example, in animals, the anchors of DNA loops are convergently oriented CTCF binding sites during interphase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4093329", "l": "EFNBs bind SDCBP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1606583", "l": "ASAH2 hydrolyzes ceramide (plasma membrane) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26163", "l": "(S)-2,3-epoxysqualene <=> thalianol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.4.9", "l": "\"dTMP kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48051", "l": "a ganglioside GM1 (d18:1(4E)) + H2O <=> a ganglioside GM2 (d18:1(4E)) + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854466", "l": "VLDLR binds RELN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70547", "l": "3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl-(1->3)-alpha-L-fucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52966", "l": "H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP => hyodeoxycholate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333609", "l": "MeSebGalNac is hydrolysed to MeSeH and bGalNac (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9667563", "l": "AVPR2 bind desmopressin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9860273", "l": "Dimerization of p-S446-IRF5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56333", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + H2O => AMP + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9652816", "l": "Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13288", "l": "ATP + L-cysteine + L-glutamate <=> ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050607", "l": "mycothiol-dependent formaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-265645", "l": "Calcium Influx through Voltage-gated Calcium Channels (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29606", "l": "benzoyl-CoA + H2O + oxidized 2[4Fe-4S]-[ferredoxin] <=> 4-hydroxybenzoyl-CoA + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070053", "l": "thrombospondin receptor activity", "d": ["Combining with thrombospondin and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8938770", "l": "RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2187395", "l": "Dephosphorylated SMAD2/3 translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4088220", "l": "Endorepellin binds alpha2beta1 integrin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33557", "l": "(4R)-hydroxysphinganine + a fatty acid => an N-acyl-(4R)-4-hydroxysphinganine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5623508", "l": "GBF1 stimulates nucleotide exchange on ARF4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46607", "l": "[HPr protein]-O-phospho-L-serine + H(+) + phosphate <=> [HPr protein]-L-serine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210921", "l": "NEUROG3-dependent synthesis of NKX2-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57249", "l": "H2O + N(2)-(1-hydroxy-2-oxoethyl)-dGTP => dGTP + glycolate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.7.99.2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050142", "l": "nitrogenase (flavodoxin) activity", "d": ["Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38825", "l": "1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9823816", "l": "OPTN binds CASP8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41127", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9667952", "l": "ANKLE2 is deacetylated by SIRT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854209", "l": "TBC1D10A binds JFC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74762", "l": "isorhamnetin + S-adenosyl-L-methionine <=> 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159790", "l": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72722", "l": "eIF2 activation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63618", "l": "H(+) + prunetin-C(8)-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39657", "l": "(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + A + 2 H2O => (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205861", "l": "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66516", "l": "1-(9Z,12Z-octadecadienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 1-(9Z,12Z,15Z-octadecatrienoyl)-2-acyl-3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16128", "l": "ATP + D-fructose <=> ADP + D-fructose 6-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67744", "l": "1-O-alkyl-2-acyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) + H2O = 1-O-alkyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814094", "l": "ARL1:GTP binds ARFIP2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874718", "l": "TTPA binds alpha-TOH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25704", "l": "H(+) + H2O + N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-dihomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047957", "l": "4'-methoxyisoflavone 2'-hydroxylase activity", "d": ["Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35892", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975122", "l": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br> (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70952", "l": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9840564", "l": "OMA1 hydrolyzes YME1L1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363328", "l": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.60", "l": "\"CDP-abequose:alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33643", "l": "(9Z)-tetradecenoate + ATP + CoA = (9Z)-tetradecenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.62", "l": "\"caspase-9\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645481", "l": "TIFA oligomerization (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72571", "l": "dehydroepiandrosterone 3-sulfate(in) + pentanoate(out) = dehydroepiandrosterone 3-sulfate(out) + pentanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12989", "l": "a dolichyl beta-D-mannosyl phosphate + H2O = a dolichyl phosphate + D-mannose + H(+)", "d": [], "t": []}, {"i": "EC:3.1.4.49", "l": "\"dolichylphosphate-mannose phosphodiesterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9707856", "l": "PGRMC2:Hemes dissociates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832813", "l": "Expression of POU3F1 in anterior neural plate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362500", "l": "TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609744", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2B (GRIN2B) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0170020", "l": "ionotropic olfactory receptor activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific odorant has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32991", "l": "2 a 1-acyl-sn-glycero-3-phosphocholine = a 1,2-diacyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68960", "l": "DNA polymerase epsilon binds at the origin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9860278", "l": "p-S446-IRF5 dimer translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047879", "l": "erythronolide synthase activity", "d": ["Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395340", "l": "Formation of hydroxyallysine by LOX (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77294", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797090", "l": "CCNK binds CDK12 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9854961", "l": "SDHAF4 binds to FAD-SDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36378", "l": "ATP + carbamoyl phosphate + H2O <=> carbamoyl adenylate + diphosphate + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419646", "l": "SEMA4D interacts with Plexin-B1:Met (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41384", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975340", "l": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18230", "l": "glycolate + NAD(+) => glyoxylate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35498", "l": "H2O + N-(4-aminobenzoyl)-L-glutamate <=> 4-aminobenzoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.52", "l": "\"beta-N-acetylhexosaminidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40063", "l": "6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O = 2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29068", "l": "formate + H(+) + menaquinone-8 => CO2 + menaquinol-8", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51314", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine => (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28614", "l": "(1Z,2S)-2-methylbutanal oxime = (2S)-2-methylbutanenitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9756162", "l": "CYP3A4 monooxygenates ATV to 4-OH-ATV (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50675", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O <=> [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.613571896142687", "identifiers": [{"i": "GO:0046812", "l": "host cell surface binding", "d": ["Binding to the surface of a host cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46531", "l": "(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-976768", "l": "Factor H binds to C3b (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609899", "l": "Tail-anchored protein:ASNA1:ADP binds WRB:CAMLG at the endoplasmic reticulum membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428909", "l": "Activated TP receptor binds G-protein  G13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174367", "l": "GCL ligates L-Glu to L-Cys (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200421", "l": "Activation of cytosolic AMPK by phosphorylation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018614", "l": "ethylbenzene dioxygenase activity", "d": ["Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047776", "l": "citramalate lyase activity", "d": ["Catalysis of the reaction: S-citramalate = acetate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55666", "l": "2 A + canthaxanthin + 3 H2O => 2 AH2 + echinenone + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.57", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209815", "l": "Tyrosine is monoiodinated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390912", "l": "HRH1 binds hist (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9652580", "l": "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855213", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36228", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + CDP-choline => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798020", "l": "TP53 binds the BTG2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951498", "l": "Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947514", "l": "PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28338", "l": "(R)-carnitinyl-CoA = crotonobetainyl-CoA + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.149", "l": "\"crotonobetainyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75363", "l": "thymidine(in) = thymidine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782820", "l": "USP17 deubiquitinates SUDS3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0015315", "l": "organophosphate:phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + phosphate(in) = organophosphate(in) +  phosphate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24369", "l": "L-ornithine => L-proline + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29753", "l": "acetoacetate(out) => acetoacetate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62386", "l": "(2R)-2,3-bisphosphoglycerate + 2 H(+) => cyclic (2R)-2,3-bisphosphoglycerate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15664", "l": "(E)-4-coumaroyl-CoA + an anthocyanidin 3,5-di-O-beta-D-glucoside <=> an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63064", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA + tetraacetate lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4085133", "l": "LUM (lumican) binds integrin alpha2beta1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2404144", "l": "Parenchymal atROL translocates to HSCs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451056", "l": "Microtubule-independent trafficking of connexons to the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-72180", "l": "Cleavage of mRNA at the 3'-end (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55641", "l": "C-terminal L-cysteinyl-[HypE protein] + carbamoyl adenylate => AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72671", "l": "eIF5B:GTP is hydrolyzed and released (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8865275", "l": "PDGF-BB clevage by Furin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.9.98.-", "l": "\"With other, known, acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047842", "l": "dehydro-L-gulonate decarboxylase activity", "d": ["Catalysis of the reaction: 3-dehydro-L-gulonate + H+ = L-xylulose + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9749609", "l": "BCHE hydrolyzes ASA- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34917", "l": "D-galactose(out) => D-galactose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29101", "l": "a menaquinol + 4 H(+)(out) + NAD(+) => a menaquinone + 5 H(+)(in) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8931981", "l": "RUNX1 binds ESR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51305", "l": "(11S)-hydroperoxy-(9Z,12Z)-octadecadienoate => (13R)-hydroperoxy-(9Z,11E)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8848873", "l": "PTK6 phosphorylates ARAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851347", "l": "B4GALT5/6 transfer Gal to GlcCer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686924", "l": "DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2737728", "l": "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901238", "l": "ABC-type tungstate transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + tungstate(in) = ADP + phosphate + tungstate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60633", "l": "all-trans-4-oxoretinol + NAD(+) => all-trans-4-oxoretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-622415", "l": "RIP2 binds NEMO (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42656", "l": "diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + H(+) + methanol", "d": [], "t": []}, {"i": "EC:3.1.1.97", "l": "\"methylated diphthine methylhydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0016797", "l": "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters."], "t": []}, {"i": "EC:3.1.16.-", "l": "\"Exonucleases active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351208", "l": "Spermidine  => N-acetylated spermidine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71354", "l": "androsterone 3alpha-sulfate(out) + 2 Na(+)(out) <=> androsterone 3alpha-sulfate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433089", "l": "SOAT can transport taurolithocholate-3-sulphate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76298", "l": "cob(I)alamin + S-adenosyl-L-methionine <=> methylcob(III)alamin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24013", "l": "gamma-tocopherol + S-adenosyl-L-methionine => (+)-alpha-tocopherol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2127562", "l": "STRAP binds phosphorylated TGF-beta receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24874", "l": "H2O + O-phospho-D-serine => D-serine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54519", "l": "8-hydroxycopalyl diphosphate <=> (13R)-manoyl oxide + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001587", "l": "Gq/11-coupled serotonin receptor activity", "d": ["Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.323347803118935", "identifiers": [{"i": "GO:0042923", "l": "neuropeptide binding", "d": ["Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2066781", "l": "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.265986832370587", "identifiers": [{"i": "GO:0140299", "l": "small molecule sensor activity", "d": ["Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016934", "l": "extracellularly glycine-gated chloride channel activity", "d": ["Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane."], "t": []}, {"i": "REACT:R-HSA-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27720", "l": "inosine + phosphate => H2O + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36939", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + tetradecanoyl-CoA = (9Z)-tetradecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4615910", "l": "SUMOylation of PCNA with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50358", "l": "4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+) => 4-hydroxy-6-methylpretetramide + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685345", "l": "Formation of isoAsp (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1112703", "l": "PTPN11 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68471", "l": "(2Z,6Z)-farnesyl diphosphate <=> (E)-gamma-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26418", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66455", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + NADP(+) <=> 1-(9Z)-octadecenoylglycerone 3-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6807106", "l": "PTEN undergoes monoubiquitination (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209828", "l": "Tryptophan is hydroxylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51092", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046222", "l": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59839", "l": "H2O + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein] <=> 3-deoxyglucosone + L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949301", "l": "RORC gene expression is stimulated by RUNX3:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034922", "l": "4,5-dihydroxypyrene dioxygenase activity", "d": ["Catalysis of the reaction: 4,5-dihydroxypyrene + O2 = phenanthrene-4,5-dicarboxylate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77075", "l": "(1R,4R,5S)-acoradiene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane carbocation + H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198941", "l": "VCAM1 binds Integrin alpha4beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866553", "l": "misfolded CFTR is degraded by the 26S proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28649", "l": "3-oxo-3-phenylpropanoate + 2 ADP + 2 H(+) + 2 phosphate => acetophenone + 2 ATP + H2O + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161775", "l": "ALOX12 oxidises LTA4 to LXA4/B4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-482770", "l": "Release of platelet secretory granule components (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68960", "l": "DNA polymerase epsilon binds at the origin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58690", "l": "H2O + NAD(+) + rifamycin SV para-naphthoquinone carboxamide => NADH + O2 + rifamycin SV", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60375", "l": "D-fructose(out) <=> D-fructose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9006850", "l": "IL21 receptor JAK phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58528", "l": "15alpha-stemmadenine intermediate I + H2O + NADPH = (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74855", "l": "dopamine + pyruvate = (R)-salsolinol-1-carboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019869", "l": "chloride channel inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of a chloride channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5627775", "l": "Autophosphorylation of PAK1,2,3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0033844", "l": "galactose-6-sulfurylase activity", "d": ["Catalysis of the elimination of sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9704297", "l": "CHRM2 binds CHRM2 antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58336", "l": "a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70479", "l": "FBP tetramers hydrolyze F1,6PP to Fru(6)P (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9753280", "l": "GSTs transfer GSH to NAPQI to form APAP-SG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416594", "l": "LARG and PDZ-RhoGEF binds to Plexin-B1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-200555", "l": "Formation of Malonyl-CoA from Acetyl-CoA (liver) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18789", "l": "D-glucosamine 6-phosphate = D-galactosamine 6-phosphate", "d": [], "t": []}, {"i": "EC:5.1.3.42", "l": "\"D-glucosamine-6-phosphate 4-epimerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54127", "l": "coelenterazine h dioxetanone <=> CO2 + excited coelenteramide h monoanion + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74655", "l": "ITP + N-acetyl-D-glucosamine = H(+) + IDP + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9728664", "l": "GLP1R binds GLP1R agonists (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0004485", "l": "methylcrotonoyl-CoA carboxylase activity", "d": ["Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61224", "l": "H2O + L-asparagine + O2 = 2-oxosuccinamate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61255", "l": "H2O + L-valine + O2 <=> 3-methyl-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033420", "l": "CUG codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CUG codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654658", "l": "Activated FGFR4:p-FRS bind to PPTN11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9844955", "l": "CLN3 transports GalCer to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160935", "l": "SMURF1 ubiquitinates RHOA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5631885", "l": "PRDX1 overoxidizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40217", "l": "FAD + H(+) + H2O2 => FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9705738", "l": "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043958", "l": "acryloyl-CoA reductase (NADH) activity", "d": ["Catalysis of the reaction: propanoyl-CoA + NAD+ = acryloyl-CoA + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-508189", "l": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-139895", "l": "tBID activates BAK protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-68712", "l": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008836", "l": "diaminopimelate decarboxylase activity", "d": ["Catalysis of the reaction: meso-2,6-diaminopimelate + H+ = L-lysine + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25097", "l": "ATP + dCMP <=> ADP + dCDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52039", "l": "H2O + L-isoleucine-(+)-12-hydroxy-7-isojasmonate <=> L-isoleucine + tuberonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52156", "l": "(E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.44", "l": "\"phenylacetaldehyde oxime monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44832", "l": "(R)-carnitine + tetradecanoyl-CoA = CoA + O-tetradecanoyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67460", "l": "(R)-malate + A = AH2 + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-380455", "l": "Recruitment of CDK11p58 to the centrosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75889", "l": "ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) => ADP-1-deoxy-1,O(4)-didehydro-D-ribose + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2559456", "l": "TIRAP binds PIP2-rich regions in the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.93", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8944233", "l": "Association of procollagen type XIX (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952631", "l": "AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990640", "l": "inositol-2,4,5-triphosphate 5-phosphatase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199456", "l": "PTEN dephosphorylates PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6798748", "l": "Exocytosis of secretory granule lumen proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45303", "l": "an N-(acyl)-sphingosylphosphocholine + H2O <=> an N-acyl-sphingoid base + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44796", "l": "2-demethylmenaquinol-13 + S-adenosyl-L-methionine = H(+) + menaquinol-13 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-266310", "l": "LCAT:spherical HDL complex <=> LCAT + spherical HDL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-193841", "l": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9613213", "l": "NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54389", "l": "1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O => 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65328", "l": "A + chrodrimanin F = AH2 + chrodrimanin H", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25561", "l": "9alpha-copalyl diphosphate => 9beta-pimara-7,15-diene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1008200", "l": "NFE2 binds the beta globin locus control region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8868567", "l": "CDK5:p25 phosphorylates PRDX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11083", "l": "dTMP + H2O <=> phosphate + thymidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76375", "l": "3 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = 3 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4546385", "l": "PIAS1,3 SUMOylates NR5A1 with SUMO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191116", "l": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3215295", "l": "USP7 deubiquitinates MDM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33226", "l": "2-oxobutanoate + CoA + NAD(+) <=> CO2 + NADH + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031625", "l": "ubiquitin protein ligase binding", "d": ["Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0060422", "l": "peptidyl-dipeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40666", "l": "L-serine <=> 2-aminoprop-2-enoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20758", "l": "2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA => (E)-caffeoyl-CoA + D-threo-isocitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14683", "l": "2-aminophenoxazin-3-one + AH2 + 2 H2O => 2 2-aminophenol + A + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18865", "l": "2-methylpropanoyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] = CoA + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein]", "d": [], "t": []}, {"i": "EC:2.3.1.168", "l": "\"dihydrolipoyllysine-residue (2-methylpropanoyl)transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3465448", "l": "Caspase-8 and FLIP(L) processing at DISC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0004301", "l": "epoxide hydrolase activity", "d": ["Catalysis of the reaction: an epoxide + H2O = an ethanediol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351901", "l": "Caspase-mediated cleavage of MST3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433542", "l": "Phosphorylation and activation of VAV1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666169", "l": "Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102463", "l": "quercetin 3-gentiobioside 7-O-rhamnosyltransferase activity", "d": ["Catalysis of the reaction: quercetin-3-gentiobioside + UDP-L-rhamnose = quercetin 3-O-gentiobioside-7-O-rhamnoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8984023", "l": "p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45272", "l": "12-phosphooxy-(9Z)-octadecenoate + H2O = 12-hydroxy-(9Z)-octadecenoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40958", "l": "(R)-5-phosphomevalonate + ATP <=> ADP + CO2 + isopentenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.25", "l": "\"1,4-lactonase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-201445", "l": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-209063", "l": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73562", "l": "dGTP(out) + UTP(in) <=> dGTP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730882", "l": "Phosphorylation of PKC-theta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420977", "l": "Ca permeable AMPA receptor ligand binding (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-912790", "l": "CBL binds CRK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696021", "l": "ADPGK:Mg2+ phosphorylates Glc to G6P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2186767", "l": "Degradation of ubiquitinated SKI/SKIL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19041", "l": "(25R)-cholest-5-ene-3beta,26-diol + O2 + reduced [NADPH--hemoprotein reductase] = (25R)-cholest-5-en-3beta,7alpha,26-triol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22229", "l": "H(+) + NADH + presqualene diphosphate => diphosphate + NAD(+) + squalene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9836184", "l": "p-PKR dimer phosphorylates CDK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9843978", "l": "CBX5 (HP-1alpha) binds TRIM28 (KAP1) in SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638104", "l": "UGCG transfers glucose to ceramide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74628", "l": "NADPH + 2 O2 + prefumagillin => acetaldehyde + fumagillin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64542", "l": "a 1,2-diacyl-sn-glycerol + an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41998", "l": "a globoside GalGb4Cer (d18:1(4E)) + H(+) + UDP => a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14831", "l": "acetate + L-cysteine => hydrogen sulfide + O-acetyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20122", "l": "ATP + L-glutamine + tRNA(Gln) => AMP + diphosphate + L-glutaminyl-tRNA(Gln)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1971491", "l": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64549", "l": "N-[(4E,6E,10S,12Z,14E)-6,10-dimethyl-3-oxohexadeca-4,6,12,14-tetraenoyl]-L-tyrosyl-[ACP] => (3E,5S)-3-[(2E,4E,8S,10E,12Z)-1-hydroxy-4,8-dimethyltetradeca-2,4,10,12-tetraen-1-ylidene]-5-[(4-hydroxyphenyl)methyl]pyrrolidine-2,4-dione + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37826", "l": "(R)-(2,4-dichlorophenoxy)propanoate + 2-oxoglutarate + O2 <=> 2,4-dichlorophenol + CO2 + pyruvate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620813", "l": "RBL2 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22405", "l": "beta-D-galacturonate + NAD(+) => D-galactaro-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32873", "l": "a carboxylate + glycerol + H(+) => a 2-acylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78675", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + silphinene = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + silphinene-15-oate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13724", "l": "H2O + testololactone <=> H(+) + testolate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5210921", "l": "pagA binds ANTXR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685902", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73814", "l": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.10", "l": "\"homocysteine S-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757688", "l": "SERPINA6 binds PREDN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72222", "l": "3 hydrogencarbonate(out) + Na(+)(out) <=> 3 hydrogencarbonate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42771", "l": "a (2S)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42305", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21550", "l": "acetate + L-lysyl-[alpha-tubulin] => H2O + N(6)-acetyl-L-lysyl-[alpha-tubulin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0003796", "l": "lysozyme activity", "d": ["Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24440", "l": "ATP + H2O + phosphate(out) = ADP + H(+) + 2 phosphate(in)", "d": [], "t": []}, {"i": "EC:7.3.2.1", "l": "\"ABC-type phosphate transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694344", "l": "Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-481044", "l": "Surface deployment of platelet alpha granule membrane components (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-159101", "l": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027321", "l": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227891", "l": "TRAF3/or TRAF6 interacts with IPS-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102929", "l": "lachrymatory factor synthase activity", "d": ["Catalysis of the reaction: 1-propenylsulfenate = propanethiol S-oxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193101", "l": "CYP11A1 cleaves 20a,22b-DHCHOL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12328", "l": "[(1->3)-alpha-D-glucosyl](n) + phosphate = [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate", "d": [], "t": []}, {"i": "EC:2.4.1.334", "l": "\"1,3-alpha-oligoglucan phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033911", "l": "mycodextranase activity", "d": ["Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31018", "l": "H(+) + indole-3-carboxylate <=> CO2 + indole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-389897", "l": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8876889", "l": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20101", "l": "a long-chain fatty acid + ATP + L-cysteinyl-[protein] = AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]", "d": [], "t": []}, {"i": "EC:6.2.1.19", "l": "\"long-chain-fatty-acid--protein ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640254", "l": "BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40599", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77944", "l": "1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate => 1,3-di-(9Z)-hexadecenoylglycerol + 9-(9Z-hexadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483229", "l": "PI:PITPNB is transported from the ER membrane to the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23359", "l": "ATP + L-seryl-[rhodopsin] <=> ADP + H(+) + O-phospho-L-seryl-[rhodopsin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70661", "l": "H(+)(out) + N,N-dimethylglycine(out) => H(+)(in) + N,N-dimethylglycine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850041", "l": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097655", "l": "serpin family protein binding", "d": ["Binding to a member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017051", "l": "retinol dehydratase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33921", "l": "24,25-dihydrolanosterol + NADP(+) => H(+) + lanosterol + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607736", "l": "MALT1 oligomerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27931", "l": "(R)-4-phosphopantoate + ATP + beta-alanine => (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33939", "l": "H(+) + L-arginine + NADH + O2 = H2O + N(omega)-hydroxy-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60022", "l": "diphosphate + sesquisabinene A => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797961", "l": "CHDH oxidises Cho to BETALD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693681", "l": "DUOX1,2 reduce O2 to H2O2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25484", "l": "(2E)-geranyl diphosphate = (1S,4R)-camphene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.117", "l": "\"(-)-camphene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41130", "l": "1-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-dodecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036106", "l": "peroxisome membrane class-2 targeting sequence binding", "d": ["Binding to a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3928624", "l": "EPHBs bind EFNBs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46123", "l": "4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 4beta,7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9647977", "l": "ICMT methylates S-Farn RAS proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36700", "l": "3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP => 8-desmethylnovobiocic acid + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26121", "l": "2-C-methyl-D-erythritol 2,4-cyclic diphosphate + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74594", "l": "(+)-exo-beta-bergamotene + 3 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> 5-dehydro-6-demethoxyfumagillol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57302", "l": "a 2'-deoxyguanosine in DNA + H(+) + lactate => an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42979", "l": "L-tryptophan <=> 2-aminoprop-2-enoate + indole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54984", "l": "a ubiquinol = a ubiquinone + 2 e(-) + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58979", "l": "H2O + malonaldehyde + O2 <=> 3-oxopropanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-199298", "l": "AKT phosphorylates CREB1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-450027", "l": "Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26154", "l": "6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate => (2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8866601", "l": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8848585", "l": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28106", "l": "galactitol 1-phosphate + NAD(+) = H(+) + keto-D-tagatose 6-phosphate + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.251", "l": "\"galactitol-1-phosphate 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70283", "l": "H2O + N-acetylputrescine + O2 = 4-acetamidobutanal + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.29", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102043", "l": "isopentenyl phosphate kinase activity", "d": ["Catalysis of the reaction: isopentenyl phosphate(2-) + ATP(4-) = isopentenyl diphosphate(3-) + ADP(3-)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-443905", "l": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5676966", "l": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64297", "l": "(4S,8R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,16,19-heptaen-18-one + H(+) + NADPH => (4S,8R,16R)-2,13,16,20-tetrahydroxy-7,9-dioxapentacyclo[10.8.0.0(3,10).0(4,8).0(14,19)]icosa-1(12),2,5,10,13,19-hexaen-18-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-77584", "l": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20098", "l": "D-mannonate => 2-dehydro-3-deoxy-D-gluconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11746", "l": "H(+) + phosphate + thiamine diphosphate => H2O + thiamine triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73621", "l": "CTP(in) + GTP(out) => CTP(out) + GTP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69908", "l": "2 Na(+)(out) + uridine(out) => 2 Na(+)(in) + uridine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-874087", "l": "SGT1 binds HSP90 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9817362", "l": "SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120053", "l": "ribitol beta-1,4-xylosyltransferase activity", "d": ["Catalysis of the reaction: UDP-D-xylose + D-ribitol 5-phosphate-R = UDP + beta1,4-xylosyl-D-ribitol 5-phosphate-R."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22204", "l": "3-hydroxyphenylacetate + H(+) + NADPH + O2 = H2O + homogentisate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32340", "l": "(+)-thujan-3-ol + NADP(+) => (+)-thujan-3-one + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77224", "l": "gentamicin X2 + methylcob(III)alamin + S-adenosyl-L-methionine => 5'-deoxyadenosine + cob(III)alamin + geneticin + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0004686", "l": "elongation factor-2 kinase activity", "d": ["Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6782208", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23690", "l": "hypoxanthine + NH4(+) => adenine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5389842", "l": "TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15145", "l": "D-maltose = alpha,alpha-trehalose", "d": [], "t": []}, {"i": "EC:5.4.99.16", "l": "\"maltose alpha-D-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8862380", "l": "HSD17B13 binds lipid droplets (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140849", "l": "ATP-dependent H2AZ histone chaperone activity", "d": ["A histone chaperone that mediates the exchange of histone H2A-H2B dimer and histone H2AZ-H2B dimers in a nucleosome, driven by ATP hydrolysis. Some chaperones insert H2AZ-H2B dimers and remove H2A-H2B, while others do the opposite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675974", "l": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65876", "l": "5alpha-androst-1-ene-3,17-dione + H2O = 1-hydroxy-5alpha-androstan-3,17-dione", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-381109", "l": "IRE1 binds IRE1 forming dimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75152", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => diphosphate + neoverrucosan-5beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27615", "l": "(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate => di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-198599", "l": "AKT phosphorylates MDM2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64270", "l": "emodin + H(+) + H2O => emodin anthrone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166726", "l": "Activation of MASPs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75602", "l": "(13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate <=> ectocarpin A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5627072", "l": "RHOQ binds GOPC:CFTR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58006", "l": "(20S)-ginsenoside Rd + H(+) + UDP => (20S)-ginsenoside F2 + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19846", "l": "nocardicin E + S-adenosyl-L-methionine => H(+) + isonocardicin A + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76618", "l": "3-oxopropanoate + CoA + H2O + NAD(+) <=> acetyl-CoA + H(+) + hydrogencarbonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72485", "l": "(S)-malate(out) + citrate(in) => (S)-malate(in) + citrate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32211", "l": "(Z)-5-oxohex-2-enedioate = (2E,4Z)-2-hydroxyhexa-2,4-dienedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38745", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,3-di-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-(9Z-octadecenoyl)-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-977605", "l": "Factor H displaces Bb (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42657", "l": "diphthine methyl ester-[translation elongation factor 2] + H2O => diphthine-[translation elongation factor 2] + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71670", "l": "PKM dephosphorylates PEP to PYR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4086132", "l": "Dentin phosphoprotein binds integrin alphaVbeta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21422", "l": "15-dehydro-prostaglandin I2 + H(+) + NADPH => NADP(+) + prostaglandin I2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "73.574107045986764", "identifiers": [{"i": "GO:0015370", "l": "solute:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)."], "t": []}, {"i": "REACT:R-HSA-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65171", "l": "AH2 + O2 + preaustinoid A <=> A + H2O + preaustinoid A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18122", "l": "an S-substituted L-cysteine + H2O => a thiol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52162", "l": "(Z)-phenylacetaldehyde oxime => (E)-phenylacetaldehyde oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15611", "l": "5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+) => ATP + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23155", "l": "a ubiquinone + H(+) + NADH <=> a ubiquinol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77601", "l": "3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol) => 2 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9650473", "l": "SERPING1 is secreted (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8987255", "l": "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3  phosphorylates STAT1,STAT3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686578", "l": "Activated ATM phosphorylates ABL1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9027627", "l": "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198563", "l": "IDO1 dioxygenates L-Trp to NFK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31210", "l": "FAD + H(+) + hexanoyl-CoA <=> (2E)-hexenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858652", "l": "MITF-M dimer binds the CDKN2A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14331", "l": "3-phosphooxypyruvate + L-glutamate => 2-oxoglutarate + O-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20149", "l": "O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.55", "l": "\"quinine 3-monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.23", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64011", "l": "(4R)-hydroxysphinganine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047281", "l": "dioxotetrahydropyrimidine phosphoribosyltransferase activity", "d": ["Catalysis of the reaction: pyrophosphate + a 2,4-dioxotetrahydropyrimidine D-ribonucleotide = PRPP + a 2,4-dioxotetrahydropyrimidine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047378", "l": "acetylalkylglycerol acetylhydrolase activity", "d": ["Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycerol + H2O = 1-alkyl-sn-glycerol + acetate + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34836", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-acyl-4-hydroxy-15-methylhexadecasphinganine => a 1,2-diacyl-sn-glycerol + N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6787642", "l": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68478", "l": "a fatty aldehyde + CO2 + H2O => a (2R)-2-hydroperoxy fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794344", "l": "HOMER binds SHANK proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73750", "l": "(R)-noradrenaline(in) + 2 H(+)(out) <=> (R)-noradrenaline(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5423647", "l": "CYP2A13 oxidises AFM1 to AFM1E (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58428", "l": "(E,E)-2,4-hexadien-1-ol + NADP(+) = (E,E)-2,4-hexadienal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672010", "l": "Active MTORC1 phosphorylates ULK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68274", "l": "CoA + O-fatty acyl-L-seryl-[protein] => a fatty acyl-CoA + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9638097", "l": "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375138", "l": "CDO binds BOC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9026777", "l": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952903", "l": "ADPRHL2 hydrolyses poly(ADP-ribose) (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-191830", "l": "snRNP nuclear import and release (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840488", "l": "PSAP(195-273) forms a dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8853503", "l": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047867", "l": "dimethylmalate dehydrogenase activity", "d": ["Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45646", "l": "H(+) + N-hexadecanoylsphing-4-enine + phosphocholine => H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-549241", "l": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47451", "l": "(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61913", "l": "ATP + H2O + voriconazole(in) => ADP + H(+) + phosphate + voriconazole(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53249", "l": "7-dehydrocholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 7-oxocholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19604", "l": "H(+) + NADH + O2 + orcinol <=> 2,3,5-trihydroxytoluene + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865546", "l": "FOXP3 gene expression is stimulated by RUNX1:CBFB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198845", "l": "CYB5A:heme reduces Asc.- to AscH- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8865637", "l": "MFSD2A transports LPC from extracellular region to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6785181", "l": "LMF1,2 bind LIPC dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55733", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] => 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-71775", "l": "SUCLG1/G2 cleaves succinyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-389354", "l": "Activation of Vav1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9027628", "l": "ALOX5 oxidises EPA to 5-HEPE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.2.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8848606", "l": "PTK6 phosphorylates PXN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036102", "l": "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BMG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5661114", "l": "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77331", "l": "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34236", "l": "4-nitro-6-oxohepta-2,4-dienedioate => 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77880", "l": "an N-(1-deoxy-beta-D-fructopyranos-1-yl)amine + H2O + O2 => (1-deoxy-D-fructos-1-yl)amine + an aldehyde + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31204", "l": "acetyl-CoA + hexanoyl-CoA => 3-oxooctanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2022911", "l": "CSPG is secreted (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46456", "l": "5alpha-cholest-8,14-dien-3beta-ol + H(+) + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2090085", "l": "HGSNAT oligomer acetylates Heparan chain(1) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65595", "l": "8-hydroxycasbene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4,8-dihydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67300", "l": "(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one = 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75074", "l": "chloride(out) + Cs(+)(in) + 2 hydrogencarbonate(in) <=> chloride(in) + Cs(+)(out) + 2 hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13004", "l": "1D-myo-inositol hexakisphosphate + H2O <=> 1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-446221", "l": "GMPPB converts Mannose-1-phosphate to GDP-Mannose (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730856", "l": "Autophosphorylation of PAK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102130", "l": "malonyl-CoA methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a malonyl-[acp] = S-adenosyl-L-homocysteine + a malonyl-[acp] methyl ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-156826", "l": "Dissociation of L13a from the 60s ribosomal subunit (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31994", "l": "(2E,6E)-farnesyl diphosphate <=> diphosphate + sesquithujene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-453346", "l": "PYGB b dimer:AMP complex <=> PGYB dimer, b form + 2 AMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52518", "l": "(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + H(+) + ubiquinol-10 => trans-4-hydroxy-L-proline + ubiquinone-10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37175", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + pentadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61233", "l": "H2O + L-isoleucine + O2 => (S)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218643", "l": "HSP90AA1 binds p-6Y-VEGFR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71501", "l": "6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out) => 6-(N-acetyl-alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31223", "l": "cis-beta-D-glucosyl-2-hydroxycinnamate + H2O = beta-D-glucose + cis-2-coumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097257", "l": "leukotriene B4 12-hydroxy dehydrogenase activity", "d": ["Catalysis of the reaction: leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57090", "l": "3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+) => an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52461", "l": "17beta-estradiol + UDP-alpha-D-glucuronate => 17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73599", "l": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-168162", "l": "Phosphorylation of human JNKs by activated MKK4/MKK7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047437", "l": "4-oxalocrotonate decarboxylase activity", "d": ["Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-448728", "l": "IL19 binds IL20RA:JAK1:IL20RB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112430", "l": "Formation of P-TEFb complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102629", "l": "patuletin 3'-O-methyltransferase activity", "d": ["Catalysis of the reaction: patuletin + S-adenosyl-L-methionine = quercetagetin 3',6-dimethyl ether + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17209", "l": "1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O = 2-formylglutarate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.2.18", "l": "\"enamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5626220", "l": "C2CD3 binds the mother centriole (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51657", "l": "keto-D-tagaturonate => keto-D-fructuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693125", "l": "RHOF binds effectors at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39336", "l": "3-oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026405", "l": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507870", "l": "Aquaporins passively transport water out of cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38337", "l": "(20S)-ginsenoside Rg3 + 2 D-glucose => (20S)-ginsenoside Rb1 + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-202960", "l": "Caspase mediated cleavage of C-IAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433415", "l": "Activation of RAC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8941895", "l": "Formation of CDK4/6:CCND complexes (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27895", "l": "3'-CMP + H2O => cytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60139", "l": "a 5-methyl-2'-deoxycytidine in DNA + L-ascorbate + O2 <=> a (8S,9R)-5-glyceryl-2'-deoxycytidine in DNA + CO2 + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73757", "l": "Binding of RRN3 to RNA Polymerase I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8877813", "l": "DENND5A,B exchange GTP for GDP on RAB39 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446208", "l": "Addition of a second mannose to the N-glycan precursor by ALG2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015475", "l": "adhesin autotransporter activity", "d": ["Enables the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632993", "l": "PTEN gene transcription is stimulated by TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4086036", "l": "PIAS1,3 SUMOylate NRIP1 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39160", "l": "(3R)-hydroxyhexadecanoyl-CoA => (2E)-hexadecenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16212", "l": "Co-precorrin-8X <=> cob(II)yrinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76228", "l": "(Z)-(indol-3-yl)-N-(sulfonatooxy)methanimidothioate => (indol-3-yl)acetonitrile + sulfate + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5358336", "l": "P4HB forms mixed disulphides with Hh precursors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32491", "l": "alpha-humulene + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-alpha-humulene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.113", "l": "\"alpha-humulene 10-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35061", "l": "chloramphenicol(out) + H(+)(in) => chloramphenicol(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.5", "l": "\"NAD(+) glycohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19760", "l": "(3R)-3-hydroxy-L-aspartate <=> NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65606", "l": "CoA + H(+) + N-eicosanoyl-(4R)-hydroxysphinganine => (4R)-hydroxysphinganine + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25244", "l": "(S)-2-ureidoglycine + H2O <=> (S)-ureidoglycolate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.38", "l": "\"isonocardicin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46881", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77443", "l": "a ganglioside GT3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GT2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708889", "l": "SARS-CoV-2 6 binds NUP98:RAE1 within NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428917", "l": "G13 activation by TP receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9909159", "l": "HK1 phosphorylates Mannose to Man6P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482771", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[9] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568846", "l": "CDKN2A (p14-ARF) SUMOylates WRN with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68026", "l": "phosphate + presqualene alcohol => H2O + presqualene phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-982810", "l": "JAK2 phosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39937", "l": "(9Z)-octadecenoate + (9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76601", "l": "(12Z)-10-hydroxyoctadecenoate => (9Z,12Z)-octadecadienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0052618", "l": "coenzyme F420-0:L-glutamate ligase activity", "d": ["Catalysis of the reaction: GTP + L-glutamate + factor F420-0 = GDP + H+ + factor gamma-F420-1 + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428273", "l": "SPHK1 phosphorylates sphingoid (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37742", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine <=> 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoserine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42499", "l": "10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate <=> 10-deacetyl-2-debenzoylbaccatin III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78934", "l": "a long-chain (3R)-hydroxyacyl-CoA <=> a long-chain (2E)-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74130", "l": "peonidin + UDP-alpha-D-galactose <=> peonidin 3-O-beta-D-galactoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847968", "l": "PTEN binds FRK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8952069", "l": "HDAC4 deacetylates RUNX3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15767", "l": "adenosylcob(III)inamide phosphate + GDP + H(+) => adenosylcob(III)inamide + GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74593", "l": "5-dehydro-6-demethoxyfumagillol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => (+)-exo-beta-bergamotene + 3 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9018824", "l": "RHOT2 binds effectors at the mitochondrial outer membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6804253", "l": "MDM2 ubiquitinates JMY (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654662", "l": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28347", "l": "7,8-dihydroneopterin 3'-triphosphate => 7,8-dihydromonapterin 3'-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38971", "l": "O2 + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2129357", "l": "Fibrillin C-terminal processing (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31342", "l": "acetate + ATP + holo-[ACP] <=> acetyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9769115", "l": "MAPK1,(MAPK3) phosphorylates NPAS4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14810", "l": "phenol + S-adenosyl-L-methionine => anisole + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72390", "l": "2 hydrogencarbonate(out) + sulfate(in) <=> 2 hydrogencarbonate(in) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51300", "l": "(9Z)-octadecenoate + L-phenylalanine = H2O + N-(9Z-octadecenoyl)-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25444", "l": "(2E,6E)-farnesyl diphosphate = (1E,4E)-germacrene B + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.71", "l": "\"(E,E)-germacrene B synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454208", "l": "Phosphorylation of beta and gamma subunits by LYN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36224", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O => 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804099", "l": "HMGB1 binds LTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12230", "l": "AMP + diphosphate + H(+) + L-asparagine + L-glutamate => ATP + H2O + L-aspartate + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-112395", "l": "Abortive termination of elongation after arrest (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201515", "l": "Active ALK recruits PI3K (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9036727", "l": "GAA hydrolyzes lysosomal glycogen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36349", "l": "4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine => N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53457", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol => 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43266", "l": "1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA => 1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168923", "l": "Collagen type XVIII endostatin release (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13335", "l": "beta-D-fructose 2-phosphate + phosphate => beta-D-fructose 2,6-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34390", "l": "beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + UDP-alpha-D-galactofuranose <=> beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426148", "l": "SREBP1A,1C binds the FASN promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8863101", "l": "SPPL2a/b cleaves TNF(1-76) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38215", "l": "D-glucose 6-phosphate + NAD(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.316703881319981", "identifiers": [{"i": "GO:0016848", "l": "carbon-halide lyase activity", "d": ["Catalysis of the breakage of a bond between carbon and any halogen atom."], "t": []}, {"i": "EC:4.5.-.-", "l": "\"Carbon-halide lyases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11547", "l": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine <=> H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482847", "l": "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9645406", "l": "ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-210444", "l": "L-Glutamate loading of synaptic vesicle (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11650", "l": "1,4-menthane-3,8-diol + H2O + NADP(+) => (-)-menthol + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.81", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9635743", "l": "PTPN7 binds p-T,Y-MAPK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57124", "l": "2-oxoglutaramate = 2-hydroxy-5-oxoproline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70786", "l": "H(+)(out) + L-aspartate(in) + L-glutamate(out) <=> H(+)(in) + L-aspartate(out) + L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204500", "l": "CyP60 chaperones Basigin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17507", "l": "a long-chain fatty acid + ethanolamine => H2O + N-(long-chain fatty acyl)ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36839", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6814678", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83677", "l": "C4 deamination of cytidine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034529", "l": "2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-3-carboxybenzalpyruvate + H2O = 3-formylsalicylic acid + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-380901", "l": "Release of docked serotonin loaded synaptic vesicle (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448741", "l": "IL22RA2 binds IL22 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65434", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+) => a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.56", "l": "\"inositol-polyphosphate 5-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865244", "l": "TFAP2A homodimer binds CDKN1A (p21) gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9750546", "l": "ABCC4 transports TPMP substrates from cytosol to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10536", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.10", "l": "\"chondro-6-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16585", "l": "[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:2.8.1.8", "l": "\"lipoyl synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917987", "l": "TFRC dimer binds 2xholoTF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8955760", "l": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18400", "l": "ATP + L-glutamate + tRNA(Glx) <=> AMP + diphosphate + L-glutamyl-tRNA(Glx)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32359", "l": "1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.151", "l": "\"inositol-polyphosphate multikinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25099", "l": "ATP + UDP => ADP + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0098918", "l": "structural constituent of synapse", "d": ["The action of a molecule that contributes to the structural integrity of a synapse."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41519", "l": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390930", "l": "5-HT2 receptor can bind serotonin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69833", "l": "6-deoxycathasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => campestanol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35150", "l": "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) <=> (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29864", "l": "AMP + GTP => ADP + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5678863", "l": "CFTR transports Cl- from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31481", "l": "H(+) + soyasapogenol A 3-O-beta-D-glucuronate + UDP => soyasapogenol A + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-204169", "l": "PDP1,2 dephosphorylate p-lipo-PDH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192425", "l": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114553", "l": "Activation of conventional Protein Kinase C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3304394", "l": "Activated TGFBR1 cannot phosphorylate SMAD2 and SMAD3 Phosphorylation Motif Mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9678854", "l": "S1PR1 binds S1PR1 agonists (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25617", "l": "terpentedienyl diphosphate = diphosphate + terpentetriene", "d": [], "t": []}, {"i": "EC:4.2.3.36", "l": "\"terpentetriene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1112703", "l": "PTPN11 is phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34193", "l": "(2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+) => (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9727607", "l": "MME:Zn2+ binds sacubitrilat (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71472", "l": "H2O + substance P => L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 + substance P(1-6)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45866", "l": "4-hydroxy-6-(15-hydroxypentadecyl)-pyran-2-one + 2 CO2 + 3 CoA => 16-hydroxyhexadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3900070", "l": "SUMOylation of MKL1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61278", "l": "5-amino-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-ornithine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22186", "l": "acenaphthene-1,2-dione + 2 H(+) + 2 NADPH => (+-)-trans-acenaphthene-1,2-diol + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665854", "l": "ADRM1:26S proteaseome binds UCHL5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851494", "l": "NTPDase7 hydrolyzes nucleoside triphosphates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8863727", "l": "STON2 is neddylated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102520", "l": "L-threonine O-3-phosphate phosphatase activity", "d": ["Catalysis of the reaction: O-phospho-L-threonine + H2O = L-threonine + hydrogenphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42739", "l": "guanosine(1207) in 16S rRNA + S-adenosyl-L-methionine <=> H(+) + N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69056", "l": "H(+) + N(omega)-methyl-L-arginine + NADH + O2 = H2O + N(delta)-hydroxy-N(omega)-methyl-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75493", "l": "25-hydroxyvitamin D3 sulfate(in) + n H(+)(in) => 25-hydroxyvitamin D3 sulfate(out) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-177930", "l": "GAB1 phosphorylation by EGFR kinase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5607721", "l": "Activation of NIK (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75995", "l": "3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.27", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851072", "l": "DNMT1-dependent PTPN6 gene silencing (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38265", "l": "2-methylfumaryl-CoA + H2O => (2R,3S)-beta-methylmalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203774", "l": "Interaction of Csk with PAG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-189421", "l": "CPO transforms COPRO3 to PPGEN9 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140496", "l": "gamma-tubulin complex binding", "d": ["Binding to a gamma-tubulin complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16726", "l": "a phosphatidylglycerol phosphate + H2O => a phosphatidylglycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-741450", "l": "SLC35A3 exchanges UDP-GlcNAc for UMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76782", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,6-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6813626", "l": "LEAP2 binds bacteria (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43919", "l": "(25R)-3-oxocholest-4-en-26-ol + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (25R)-3-oxocholest-4-en-26-al + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875558", "l": "RAPGEF1 binds CRK,CRKL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938231", "l": "RUNX1:CBFB binds CREBBP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72180", "l": "Cleavage of mRNA at the 3'-end (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653585", "l": "S-Farn-Me KRAS4B binds calmodulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57609", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) => 3-chlorocatechol + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-992708", "l": "Dual-specific AKAPs bind type I and II PKA regulatory subunits (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9640175", "l": "v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8943817", "l": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.26", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004775", "l": "succinate-CoA ligase (ADP-forming) activity", "d": ["Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755044", "l": "PNP trimer transforms RBV to T-CONH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34711", "l": "H2O + N-acyl-15-methylhexadecasphing-4-enine = 15-methylhexadecasphing-4-enine + a fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78529", "l": "4 H(+) + N(6)-dimethyladenosine(N)/N(6)-dimethyladenosine(N+1) in rRNA + 4 S-adenosyl-L-homocysteine => adenosine(N)/adenosine(N+1) in rRNA + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879934", "l": "Recruitment of SHC1 is mediated by Y593 of the common beta chain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1251997", "l": "Cleavage of ERBB4m80 by gamma-scretase complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57087", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O <=> a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161549", "l": "PGH2 is reduced to PGF2a by AKR1C3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757451", "l": "ASA-,ST translocate from cytosol to ER lumen of hepatocytes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052727", "l": "capsanthin synthase activity", "d": ["Catalysis of the reaction: antheraxanthin = capsanthin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042736", "l": "NADH kinase activity", "d": ["Catalysis of the reaction: ATP + NADH = ADP + 2 H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48722", "l": "4-hydroxy-2-methyl-3-oxo-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH => aurachin B + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54703", "l": "4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] <=> 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51937", "l": "2-(glutathione-S-yl)-hydroquinone + glutathione => glutathione disulfide + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67254", "l": "3-oxopropanoate + 2 H(+) + NADH => H2O + malonaldehyde + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29680", "l": "formate(in) => formate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11890", "l": "a carboxylate + 2 H(+) + NADPH => an aldehyde + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682103", "l": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191636", "l": "Phosphorylation of Cx43 by c-src (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19022", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine => an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8849345", "l": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10862", "l": "2-(acetamidomethylene)succinate + NAD(+) => 3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102423", "l": "(+)-sesaminol 2-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-sesaminol + UDP-alpha-D-glucose = (+)-sesaminol 2-O-beta-D-glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-165179", "l": "Formation of TSC1:TSC2 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1306876", "l": "NLRP3 activation by small molecules (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9701525", "l": "p-Y705,S727-STAT3 dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58134", "l": "AH2 + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + serpentine => A + ajmalicine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-190261", "l": "FGFR3c binds to FGF (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10047", "l": "cyclohexanol + NAD(+) <=> cyclohexanone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237042", "l": "AQP1 tetramer transports CO2 from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9661419", "l": "ALB binds extracellular heme (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1236958", "l": "Interaction of particulate antigens with dendritic cell receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56348", "l": "4-hydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 = 2,4-dibromophenol + CO2 + 4 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6814555", "l": "Integrator complex processes the 3' end of snRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5218812", "l": "FYN phosphorylates PAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014456", "l": "GDIs block activation of RHOG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42932", "l": "cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617828", "l": "TRIP11:IFT20 dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5252133", "l": "ATP6AP1 binds V-ATPase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374663", "l": "DCC interaction with Ezrin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140444", "l": "cytoskeleton-nuclear membrane anchor activity", "d": ["The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56025", "l": "H2O + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) => beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9026894", "l": "Activated PCLG1 dissociates from NTRK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5205824", "l": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78500", "l": "CMP-5'-(N-acetyl-N-hydroxy-3-aminopropyl)phosphonate + H2O => 3-(N-acetyl-N-hydroxy)aminopropylphosphonate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380782", "l": "STAT binds to the active receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5662608", "l": "MT2A binds cadmium (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849878", "l": "PSD-95 binds NMDA receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18154", "l": "2 GTP + H(+) => diphosphate + P(1),P(4)-bis(5'-guanosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109858", "l": "MAP2K2 binds MAPK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29440", "l": "Fe(2+)(in) + H(+)(out) => Fe(2+)(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71590", "l": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54267", "l": "2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2 <=> (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75889", "l": "DHAP is converted to G3P by GPD1/GPD1L (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047686", "l": "arylsulfate sulfotransferase activity", "d": ["Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47331", "l": "1,2-di-(9Z)-octadecenoyl-sn-glycero-3-phospho-L-serine + H2O <=> (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204779", "l": "Interaction of Tie2 with Ang1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78798", "l": "a 3-oxoacyl-[ACP] + acetyl-[ACP] + H2O <=> a 3-carboxymethyl-3-hydroxy-acyl-[ACP] + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174445", "l": "RPA binds to the Flap on the C-strand (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.33", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9839377", "l": "TGFB1,TGFB2 bind TGFBR3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085033", "l": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75673", "l": "14,15-epoxy-12-hydroxy-(10E,17Z)-eicosadienoate => 12-hydroperoxy-(10E,14Z,17Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213195", "l": "Formation of anchoring fibrils (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14223", "l": "H(+) + methanol + sulfate => H2O + monomethyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9035484", "l": "CysS248-MPST:TXN2 dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351207", "l": "Spermine  => N-acetylated spermine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73423", "l": "L-asparagine(out) = L-asparagine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4615910", "l": "SUMOylation of PCNA with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45785", "l": "2 H2O + phenylpropanonitrile => 3-phenylpropanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9865412", "l": "TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3371359", "l": "FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70830", "l": "L-arginine(in) + L-lysine(out) <=> L-arginine(out) + L-lysine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75066", "l": "chloride(out) + 2 hydrogencarbonate(in) + Li(+)(in) <=> chloride(in) + 2 hydrogencarbonate(out) + Li(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47499", "l": "lithocholate + NADP(+) <=> 3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12133", "l": "ATP + Cd(2+)(in) + H2O => ADP + Cd(2+)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55214", "l": "formyl-CoA + pentadecanal => (2R)-hydroxyhexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22717", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685230", "l": "CHEK1 phosphorylates RAD51 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9646468", "l": "mTORC1 binds RHEB:GTP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19016", "l": "dTTP + H2O <=> dTDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0008482", "l": "sulfite oxidase activity", "d": ["Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198958", "l": "KIR2DL2/3 interacting with HLA-C group 1 (Cw4) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9678561", "l": "IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785047", "l": "IL10 positively regulates extracellular inflammatory mediators (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031278", "l": "alpha-1,2-galactosyltransferase activity", "d": ["Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602484", "l": "Activation of proMMP11 by FURIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050040", "l": "lactate 2-monooxygenase activity", "d": ["Catalysis of the reaction: (S)-lactate + O2 = acetate + CO2 + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2314569", "l": "GOLGA2 phosphorylated by CDK1 is unable to promote fusion of ER to Golgi transport vesicles with cis-Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47258", "l": "6beta-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68256", "l": "L-cystine(in) + Na(+)(in) = L-cystine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-606326", "l": "HJURP:CENPA complex localizes to the centromere (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-164423", "l": "PhosphoChREBP (Thr 653) is exported to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877361", "l": "Pyrin binds ASC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030563", "l": "snRNA 2'-O-ribose methylation guide activity", "d": ["Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.244991688848543", "identifiers": [{"i": "GO:0016417", "l": "S-acyltransferase activity", "d": ["Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388596", "l": "Melanocortin receptors bind melanocortins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43322", "l": "a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine => 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.16", "l": "\"protein-serine/threonine phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44407", "l": "3-demethylubiquinol-7 + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + ubiquinol-7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-109638", "l": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24068", "l": "cyclohexanone + H(+) + NADPH + O2 = H2O + hexano-6-lactone + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.22", "l": "\"cyclohexanone monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9860295", "l": "SLC15A4 binds TASL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66175", "l": "H(+)(out) + L-cystine(out) <=> H(+)(in) + L-cystine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389891", "l": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446868", "l": "The Interleukin 1 receptor complex binds Tollip (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613760", "l": "EGR2 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77296", "l": "a ganglioside GD3 + CMP-N-acetyl-beta-neuraminate => a ganglioside GT3 + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18069", "l": "L-arginine = D-arginine", "d": [], "t": []}, {"i": "EC:5.1.1.9", "l": "\"arginine racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68702", "l": "16alpha,17beta-estriol 17-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+) => 16alpha,17beta-estriol 17-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69406", "l": "uracil(out) => uracil(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938389", "l": "RUNX1:CBFB binds the LGALS3 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9644869", "l": "p-S54-PDE4B hydrolyses cAMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-937311", "l": "ATP12A:ATP4B exchanges K+ for H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191784", "l": "snRNA Cap hypermethylation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51316", "l": "(9Z)-octadecenoate + glycine = H2O + N-(9Z-octadecenoyl)glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23856", "l": "H(+) + Hg + NADP(+) = Hg(2+) + NADPH", "d": [], "t": []}, {"i": "EC:1.16.1.1", "l": "\"mercury(II) reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51060", "l": "5alpha-androst-1-ene-3,17-dione + A = AH2 + androsta-1,4-diene-3,17-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9614185", "l": "Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38983", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950173", "l": "Expression of ADP-ribosylation factor 1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56964", "l": "a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate = a 2'-deoxyribonucleoside 5'-diphosphate + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47050", "l": "3-dehydroshikimate + a quinol => a quinone + shikimate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73301", "l": "(S)-malate(in) + H(+)(out) + phosphate(out) => (S)-malate(out) + H(+)(in) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27890", "l": "3'-UMP + H2O = phosphate + uridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9708517", "l": "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664867", "l": "NBR1 binds MAP1LC3B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34429", "l": "(-)-pinoresinol + H(+) + NADPH => (-)-lariciresinol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54224", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphocholine = 2-(prostaglandin E2)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41587", "l": "dimethylallyl diphosphate + L-tyrosine <=> 4-O-dimethylallyl-L-tyrosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10692", "l": "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone", "d": [], "t": []}, {"i": "EC:1.3.3.11", "l": "\"pyrroloquinoline-quinone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015638", "l": "microcin transmembrane transporter activity", "d": ["Enables the transfer of a microcin from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5357780", "l": "TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787533", "l": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5689972", "l": "USP2 deubiquitinates MDM2,MDM4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9714694", "l": "RAC3 translocates to the endoplasmic reticulum membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202718", "l": "Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78162", "l": "RNA(n)-3'-adenine ribonucleotide <=> 2',3'-cyclophospho-AMP + RNA(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-140355", "l": "Arachidonic acid is oxidised to PGG2 by PTGS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191790", "l": "Loading and methylation of Sm proteins onto SMN Complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33793", "l": "beta-D-fructose + beta-D-glucose 6-phosphate => H2O + sucrose 6(F)-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71989", "l": "diphosphate + fusoxypene C => (2E,6E,10E,14E)-geranylfarnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74417", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in) => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793096", "l": "MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47072", "l": "1-eicosanoylglycerol + H2O = eicosanoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62668", "l": "deoxyherqueinone + H(+) + NADPH + O2 = H2O + herqueinone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40145", "l": "(9Z,12Z)-octadecadienoate + CoA + H(+) => (9Z,12Z)-octadecadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45380", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9821476", "l": "CXXC1 and WDR82 bind SET1B complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-168140", "l": "Active IKK Complex phosphorylates NF-kappa-B inhibitor  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.2.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210805", "l": "Removal of miRNA passenger strand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102172", "l": "4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 + H+ = 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.325", "l": "\"juvenile hormone-III synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59490", "l": "ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate => ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450337", "l": "Activated TAK1 phosphorylates MKK4/MKK7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9610750", "l": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38079", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51858", "l": "(2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in) => (E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22447", "l": "(E)-coniferol + NADP(+) <=> (E)-coniferaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351877", "l": "Caspase-mediated cleavage of Desmoglein 2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10183", "l": "(6R)-10-formyltetrahydrofolate + H2O + NADP(+) <=> (6S)-5,6,7,8-tetrahydrofolate + CO2 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694447", "l": "mRNA2 is translated to Spike (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54549", "l": "D-xylulose 1,5-bisphosphate + H2O => D-xylulose 5-phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9844955", "l": "CLN3 transports GalCer to plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20658", "l": "4-chlorophenylacetonitrile + 2 H2O => 4-chlorophenylacetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193763", "l": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3769391", "l": "XPO1 binds the beta-catenin:CBY complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9839401", "l": "TGFBR3 degradation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33999", "l": "zymosterol = 5alpha-cholesta-7,24-dien-3beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004153", "l": "dihydropterin deaminase activity", "d": ["Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548800", "l": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6782628", "l": "USP8 deubiquitinates STAM2:HGS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29118", "l": "H(+) + menaquinone-8 + NADPH <=> menaquinol-8 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56624", "l": "2,4,5-trichlorocyclohexa-2,5-dien-1-ol + H2O = 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9605609", "l": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0106075", "l": "peptide N-succinyltransferase activity", "d": ["Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: succinyl-CoA + peptide = CoA + N-succinylpeptide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983153", "l": "E1 mediated ubiquitin activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964619", "l": "PAK1 binds ARHGEF6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692880", "l": "HRH3 binds Hist (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617855", "l": "HOXC4 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011961", "l": "GREB1 translation is negatively regulated by miR-26A and B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855157", "l": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74192", "l": "carbofuran + H(+) + H2O => 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-ol + CO2 + methylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-9635440", "l": "PapA5 transforms mycocerosyl to PDIM (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5625849", "l": "Demethylase KDM1A binds KLK2 and KLK3 promoters (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4085083", "l": "Tumstatin binds integrin alphaVbeta 3, alpha3beta1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209061", "l": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1955380", "l": "TIMM9:TIMM10 transfers proteins to TIMM22 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043839", "l": "lipid A phosphate methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate group of lipid A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-209738", "l": "VD3 binds GC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9669854", "l": "KIT binds type II TKIs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8931858", "l": "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24599", "l": "acetyl-CoA + L-histidine <=> CoA + H(+) + N(alpha)-acetyl-L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57823", "l": "[phosphate](n) + ADP <=> [phosphate](n+1) + AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9623384", "l": "α1-agonists bind ADRA1A,B,D (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53382", "l": "H(+) + NADH + uridine(16) in tRNA => 5,6-dihydrouridine(16) in tRNA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54375", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-(2S,3R,9R)-pristinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170676", "l": "Adenylate cyclase converts ATP into cyclic AMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047435", "l": "5-guanidino-2-oxopentanoate decarboxylase activity", "d": ["Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H+ = 4-guanidinobutanal + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482794", "l": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36049", "l": "(R)-glycerate + AH2 + H(+) => A + D-glyceraldehyde + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40969", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-glycerol + H(+) => 1,2-di-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047155", "l": "3-hydroxymethylcephem carbamoyltransferase activity", "d": ["Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2990842", "l": "SENP1,2,5 proteolytically process SUMO2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-212380", "l": "Formation of TRAP coactivator complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24985", "l": "(1S)-1,23-dihydroxy-24,25,26,27-tetranorcalciol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2855020", "l": "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-376419", "l": "Formation of NR-MED1 Coactivator Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30675", "l": "tetrahymanol = H2O + squalene", "d": [], "t": []}, {"i": "EC:4.2.1.123", "l": "\"tetrahymanol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6800426", "l": "Exocytosis of ficolin-rich granule membrane proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57920", "l": "4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) = H(+) + L-asparaginyl-tRNA(Asn) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031873", "l": "type 2 proteinase activated receptor binding", "d": ["Binding to a type 2 proteinase activated receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-868657", "l": "Glucanotrehalose is hydrolyzed to 1,4-alpha-glucan and trehalose (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0030276", "l": "clathrin binding", "d": ["Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681314", "l": "Replication transcription complex binds SARS-CoV-1 genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40437", "l": "H(+) + hexadecanoate + sn-glycerol 3-phosphocholine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944223", "l": "Association of procollagen type V (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8937022", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57436", "l": "guaethol + O2 + reduced [NADH--hemoprotein reductase] = acetaldehyde + catechol + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63148", "l": "H2O + N-(9Z-octadecenoyl)-taurine = (9Z)-octadecenoate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449937", "l": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63029", "l": "(15Z)-tetracosenamide + H2O => (15Z)-tetracosenoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73932", "l": "Resynthesis of excised residue by POLB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78505", "l": "(R)-(3-(acetylhydroxyamino)-2-hydroxypropyl)phosphonate + CO2 + succinate => 2-oxoglutarate + 3-(N-acetyl-N-hydroxy)aminopropylphosphonate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951676", "l": "RUNX3 binds TEADs and YAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027281", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70474", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in single-stranded DNA + H2O + O2 <=> a 2'-deoxycytidine in single-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6807565", "l": "GNLY is transferred to the phagosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-139920", "l": "Translocation of tBID to mitochondria (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52494", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193961", "l": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-434382", "l": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39383", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57882", "l": "3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP => 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-350600", "l": "Antizyme inhibitor binds to OAZ and stablizes ODC complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48580", "l": "[pyruvate, water dikinase]-phosphate + H(+) + phosphate = [pyruvate, water dikinase] + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.4.28", "l": "\"([Pyruvate, water dikinase] phosphate) phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-434989", "l": "SEMA7A binds to PLXNC1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.142077680952909", "identifiers": [{"i": "GO:0140597", "l": "protein carrier chaperone", "d": ["Binding to and carrying a protein between two different cellular components by moving along with the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805546", "l": "Keratin type I binds keratin type II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42431", "l": "clavaminate <=> (3R,5R)-clavulanate-9-aldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-351948", "l": "Mitochondrial recruitment of Drp1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4420153", "l": "p-6Y-VEGFR2 binds PLCG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110218", "l": "Cleavage of uracil by TDG glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67854", "l": "FMN-N(5)-peroxide => FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5252133", "l": "ATP6AP1 binds V-ATPase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685011", "l": "ATR activation at DNA DSBs (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70941", "l": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39100", "l": "3-oxodecanedioyl-CoA + CoA => acetyl-CoA + octanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48956", "l": "[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47491", "l": "12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isodeoxycholate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-388503", "l": "Oxytocin receptor bind oxytocin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-201669", "l": "Beta-catenin translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73800", "l": "SAICAR => AICAR + Fumarate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58734", "l": "5-methyl-CMP + diphosphate + H(+) => 5-methyl-CTP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46035", "l": "H2O2 + tetradecanoate <=> (2S)-hydroxytetradecanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102893", "l": "betanidin 6-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + betanidin = H+ + gomphrenin I + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807866", "l": "GBF1 recruits ARF:GDP to the ERGIC (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665989", "l": "DIAPH1 binds RHOA:GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68426", "l": "(3R)-hydroxy-beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial => (3R)-3-hydroxy-10'-apo-beta-carotenal + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111879", "l": "PIP2 hydrolysis (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.242", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799604", "l": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36933", "l": "(9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => 2 Fe(II)-[cytochrome b5] + 2 H(+) + hexadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25480", "l": "acetoacetate + succinyl-CoA = acetoacetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653754", "l": "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16231", "l": "a CDP-1,2-diacyl-sn-glycerol + diphosphate => a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690702", "l": "LYN phosphorylates CD22 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53325", "l": "2-glyceryl-prostaglandin H2 => 2-glyceryl-prostaglandin E2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53028", "l": "lithocholate + UDP-alpha-D-glucuronate = H(+) + lithocholoyl-3-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70055", "l": "AH2 + cremeomycin = 2-hydroxy-4-methoxybenzoate + A + N2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59160", "l": "ATP + docosanoate + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + docosanoyl-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1013833", "l": "Cables link CDK5 and ABL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018638", "l": "toluene 4-monooxygenase activity", "d": ["Catalysis of the reaction: toluene + H+ + NADH + O2 = 4-methylphenol + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2317332", "l": "PIP3 recruits AKT to the membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34427", "l": "(-)-lariciresinol + NADP(+) = (-)-pinoresinol + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.23.1.3", "l": "\"(-)-pinoresinol reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54179", "l": "a long-chain fatty aldehyde + holo-[ACP] + NADP(+) <=> a long-chain fatty acyl-[ACP] + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1454781", "l": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35312", "l": "3-hydroxyisoheptadecanoyl-CoA + NADP(+) => 3-oxoisoheptadecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001588", "l": "dopamine neurotransmitter receptor activity, coupled via Gs", "d": ["Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987105", "l": "IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9731393", "l": "EDNRA, EDNRB bind non-selective ERAs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70864", "l": "L-glutamine(out) + L-threonine(in) + Na(+)(out) => L-glutamine(in) + L-threonine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950405", "l": "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47902", "l": "a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + N-acetylneuraminate => a ganglioside GM3 (d18:1(4E)) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40744", "l": "(20S)-ginsenoside Rd + 2 H2O => (20S)-ginsenoside C-K + 2 D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102627", "l": "parthenolide 3beta-hydroxylase activity", "d": ["Catalysis of the reaction: parthenolide + NADPH + O2 + H+ = 3beta-hydroxyparthenolide + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44812", "l": "1,4-dihydroxy-2-naphthoate + all-trans-undecaprenyl diphosphate + H(+) = 2-demethylmenaquinol-11 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-354173", "l": "Activation of Rap1 by cytosolic GEFs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983147", "l": "Release of E3 from polyubiquitinated substrate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-417890", "l": "P2Y5 receptor can bind to LPA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15918", "l": "an aldopyranose + NAD(+) => aldono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229138", "l": "MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4615900", "l": "PIAS1 SUMOylates SATB2 with SUMO3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68944", "l": "Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760097", "l": "AcK-NFE2L2 and MAFK bind the GSTA1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22563", "l": "(3R)-vestitone + NADP(+) <=> 2'-hydroxyformononetin + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955817", "l": "PRODH2 oxidises HPRO to 1PYR-5COOH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45317", "l": "H(+) + NADPH + prostaglandin D2 => 11beta-prostaglandin F2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48293", "l": "a ganglioside GM1 + GDP-beta-L-fucose => a ganglioside Fuc-GM1 + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070401", "l": "NADP+ binding", "d": ["Binding to the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-917700", "l": "MVB Vesicle Formation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27957", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> diphosphate + presilphiperfolan-8beta-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5634103", "l": "SUMO-CRABP2 dissociates from atRA:RAR:RXR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265010", "l": "Proinsulin translocates from the endoplasmic reticulum to the Golgi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5674385", "l": "p-T,Y MAPKs dimerize (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570463", "l": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5685319", "l": "CX3 complex formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38235", "l": "(9Z)-octadecenoyl-CoA + octadecan-1-ol = 1-O-octadecyl (9Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4090408", "l": "PIAS1,3 SUMOylate ESR1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20779", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose <=> myo-inositol + stachyose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64910", "l": "CMP + 2 H(+) + 2 phosphate => CTP + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12420", "l": "ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.144", "l": "\"tagatose-6-phosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5621347", "l": "PLCG2 translocates from cytosol to plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-83791", "l": "Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30924", "l": "(R)-glycerate + ADP-alpha-D-glucose => (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082405", "l": "Phosphorylation of HSF1 at Ser326 induces transactivation (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22482", "l": "4-nitroquinoline N-oxide + 2 H(+) + 2 NADH => 4-(hydroxyamino)quinoline N-oxide + H2O + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047394", "l": "glycerophosphoinositol inositolphosphodiesterase activity", "d": ["Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27665", "l": "(S)-2-hydroxyglutarate + O2 <=> 2-oxoglutarate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71043", "l": "L-alanine(in) + L-phenylalanine(out) = L-alanine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047968", "l": "glyoxylate dehydrogenase (acylating) activity", "d": ["Catalysis of the reaction: CoA + glyoxylate + NADP+ = H+ + NADPH + oxalyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41788", "l": "acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.38", "l": "\"[acyl-carrier-protein] S-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62879", "l": "AH2 + methyl 2-[(3S)-9,10-dihydroxy-7-methoxy-1-oxo-1H,3H,4H-naphtho[2,3-c]pyran-3-yl]acetate <=> A + semiviriditoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56474", "l": "(5-bromo-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O => (1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + bromide + FADH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4551604", "l": "PIAS4 SUMOylates PARP1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66944", "l": "3 O2 + 3 reduced [NADPH--hemoprotein reductase] + soppiline B = 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + soppiline C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56571", "l": "a globoside Gb4Cer + UDP-N-acetyl-alpha-D-galactosamine <=> a globoside IV3GalNAc-Gb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.2.22", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38380", "l": "(9Z)-octadecenoate + 1,2-di-(9Z-octadecenoyl)-glycerol + H(+) => 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951500", "l": "Dissociation of CANX from nonameric complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-983138", "l": "Transport of MHC heterotrimer to ER exit site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57122", "l": "1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.145", "l": "\"3beta-hydroxy-Delta(5)-steroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5340214", "l": "CYGB binds O2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8938930", "l": "RUNX1 binds ELF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68183", "l": "a short-chain fatty acyl-CoA + H2O <=> a short-chain fatty acid + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-933536", "l": "p-IRF7 dimer interacts with coactivator CBP/p300 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218916", "l": "p-MAPK2/3 phosphorylates HSP27 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038149", "l": "C-C motif chemokine 2 receptor activity", "d": ["Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9705584", "l": "HMGCR dimer binds statins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046409", "l": "p-coumarate 3-hydroxylase activity", "d": ["Catalysis of the reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395801", "l": "Phosphorylation of LAT by p-SYK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029467", "l": "Activation of RAC1 by CRKII:DOCK180:ELMO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5213464", "l": "RIPK1 is phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-197198", "l": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6809014", "l": "cis-Golgi cis-SNARE binds NSF and SNAPs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74824", "l": "2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9760402", "l": "ILF3 binds HOXC8 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43689", "l": "N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + pyruvate => L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10201", "l": "butanoate + NAD(+) => (2E)-2-butenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3828025", "l": "DCN (decorin) degradation by MMP14 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20155", "l": "ADP + beta-L-arabinose 1-phosphate + H(+) => ATP + L-arabinose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-162797", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904483", "l": "synthetic cannabinoid binding", "d": ["Binding to synthetic cannabinoid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047355", "l": "CDP-glycerol glycerophosphotransferase activity", "d": ["Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140417", "l": "intracellularly ATP-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a ATP has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27685", "l": "ATP + dTDP <=> ADP + dTTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9859172", "l": "DLD dimer dehydrogenates dihydrolipoyl (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5691001", "l": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866279", "l": "Epsin family proteins bind ubiquitinated cargo (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25907", "l": "futalosine + H2O <=> dehypoxanthine futalosine + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249371", "l": "TBK1 phosphorylates STAT6 at Ser407 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676005", "l": "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-383373", "l": "Tachykinin receptor 3 (NK3) binds to neurokinin B (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37927", "l": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate = 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33827", "l": "ergosterol = vitamin D2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990055", "l": "phenylacetaldehyde synthase activity", "d": ["Catalyzes the reaction: L-phenylalanine + O2 + H2O -> phenylacetaldehyde + ammonia + hydrogen peroxide + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19922", "l": "D-ribitol 5-phosphate + NADP(+) => D-ribulose 5-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9674808", "l": "CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70071", "l": "O2 + reduced [NADPH--hemoprotein reductase] + sitosterol = (22S)-22-hydroxysitosterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2065355", "l": "Secreted ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50813", "l": "androst-4-ene-3,17-dione + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1alpha-hydroxyandrost-4-ene-3,17-dione + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1028788", "l": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46229", "l": "apo-[peptidyl-carrier protein] + CoA => adenosine 3',5'-bisphosphate + H(+) + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70654", "l": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174491", "l": "Transport of trimeric ENV precursor to Golgi apparatus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047796", "l": "cyclohexane-1,3-dione hydrolase activity", "d": ["Catalysis of the reaction: cyclohexane-1,3-dione + H2O = 5-oxohexanoate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798624", "l": "ZNF420 binds TP53AIP1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836159", "l": "p-PKR dimer phosphorylates DHX9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653974", "l": "Ragulator binds Rag dimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62221", "l": "phyllostine => neopatulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-74712", "l": "Dissociation of IRS-P from insulin receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64810", "l": "CoA + H(+) + O-(2-acetamidoethyl)-L-serine => acetyl-CoA + O-(2-aminoethyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31603", "l": "(Z)-3-ureidoacrylate + H2O = (Z)-3-aminoacrylate + carbamate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16188", "l": "an aldehyde + H2O + NAD(+) <=> a carboxylate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57425", "l": "guaiacol + O2 + reduced [NADH--hemoprotein reductase] => catechol + formaldehyde + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694454", "l": "Replication transcription complex binds SARS-CoV-2 genomic RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373711", "l": "DCC interaction with Netrin-1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22766", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610745", "l": "SCF(beta-TrCP) ubiquitinates p-GLI2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1676024", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71296", "l": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-947499", "l": "Exchange of oxygen with sulfur in MoCo (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54370", "l": "acetoin + CO2 => acetaldehyde + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-69142", "l": "Recruitment of Dna2 endonuclease (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615721", "l": "HSPA8 binds substrate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9753632", "l": "CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-425822", "l": "K+-independent Li+/Ca2+ exchanger transport (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23613", "l": "1,2-dihydro-alpha-santonin + NAD(+) => alpha-santonin + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60650", "l": "an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine => an N-(acyl)-sphingosylphosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9026005", "l": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64684", "l": "L-threonyl-[protein] + UDP-alpha-D-glucose = 3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161948", "l": "Arachidonic acid  is converted to 12-oxoETE by ALOX12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848355", "l": "PNPLA4 hydrolyzes retinyl palmitate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9840833", "l": "bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27438", "l": "2 glutathione amide + H2O2 => glutathione amide disulfide + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0003978", "l": "UDP-glucose 4-epimerase activity", "d": ["Catalysis of the reaction: UDP-glucose = UDP-galactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9610166", "l": "p-T,Y MAPK dimers translocate to nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68565", "l": "6-methoxycoumarin + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008281", "l": "sulfonylurea receptor activity", "d": ["Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72673", "l": "Release of 40S and 60S subunits from the 80S ribosome  (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-448480", "l": "IL22 binds IL22RA1:JAK1 receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49942", "l": "(10aS)-10,10a-dihydrophenazine-1-carboxylate + H2O2 => (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851139", "l": "STAT3-dependent MIR-21 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61594", "l": "3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + 2 H(+) + hydrogen sulfide + L-methionine => H2O + L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836275", "l": "TFAP2A binds TFAP2B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-83650", "l": "FasL:Fas binds FADD (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30225", "l": "2 Fe(II)-[cytochrome c] + H(+) + sulfur => 2 Fe(III)-[cytochrome c] + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420214", "l": "The adrenomedullin receptor can bind adrenomedullin and intermedin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839073", "l": "HTRA2 binds NDUFA13 (GRIM-19) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71475", "l": "H2O + neurotensin = L-isoleucyl-L-leucine + neurotensin(1-11)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018708", "l": "thiol S-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38888", "l": "H2O + N-hexanoyl-sphinganine => hexanoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14005", "l": "H2O + L,L-cystathionine = 2-oxobutanoate + L-cysteine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837419", "l": "PANK4 hydrolyzes PPANT to pantetheine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9013438", "l": "RHOD binds effectors at the endosome membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52687", "l": "NAD(+) + pyridoxine <=> H(+) + NADH + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41251", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 7R-hydroxy-5S,6S-epoxy-(8Z,11Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42140", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-(4R)-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64231", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051870", "l": "methotrexate binding", "d": ["Binding to methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22541", "l": "5'-dehydroadenosine + H2O + O2 => 9-riburonosyladenine + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-397835", "l": "Thrombin-activated PARs:Gq (active) dissociate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37662", "l": "anthraniloyl-CoA + methanol <=> CoA + O-methyl anthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56939", "l": "17beta-hydroxy-androst-5-en-3-one <=> testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50470", "l": "19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 9 CoA + 9 H2O + 18 NADP(+) => 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 27 H(+) + 9 malonyl-CoA + 18 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.71648590403835", "identifiers": [{"i": "GO:0015296", "l": "monoatomic anion:monoatomic cation symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56077", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362427", "l": "Hh-Np binds GPC5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983003", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70159", "l": "folate(in) + H(+)(in) = folate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58870", "l": "4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O => 24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76105", "l": "(11R)-methyl carlactonoate + S-adenosyl-L-homocysteine => (11R)-carlactonoate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9671145", "l": "DKC1 binds SHQ1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1675988", "l": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14545", "l": "H2O + nicotinamide = NH4(+) + nicotinate", "d": [], "t": []}, {"i": "EC:3.5.1.19", "l": "\"nicotinamidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786101", "l": "IL4 binds IL4R:JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0008086", "l": "light-activated voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1295613", "l": "SPRY2 binds GRB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14191", "l": "N-formyl-D-kynurenine => D-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73739", "l": "Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2187401", "l": "MTMR4 dephosphorylates SMAD2/3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59667", "l": "D-cellopentaose + O2 <=> D-cellopentaono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27483", "l": "acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55835", "l": "cortisone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200740", "l": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65120", "l": "H2O + S-[(2E,6E,10E)-geranylgeranyl]-L-glutathione = L-glutamate + S-[(2E,6E,10E)-geranylgeranyl]-L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2672196", "l": "Viral serpin blocks caspase-8 activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4085029", "l": "NEU2 hydrolyzes Neu5Ac from glycoconjugates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391942", "l": "IP receptor can bind prostacyclin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3000399", "l": "RANBP2 SUMOylates SP100 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018761", "l": "bromoxynil nitrilase activity", "d": ["Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxybenzoate + NH4. Involved in the bacterial degradation of the herbicide bromoxynil."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9013006", "l": "RHOA:GTP translocates to the ER membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25632", "l": "myricetin + S-adenosyl-L-methionine <=> H(+) + laricitrin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15610", "l": "ATP + D-ribose 5-phosphate => 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61796", "l": "holo-[peptidyl-carrier protein] + L-tryptophyl-5'-AMP = AMP + L-tryptophyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21492", "l": "2,3-dihydroxybenzoate + H(+) = catechol + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.46", "l": "\"o-pyrocatechuate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44736", "l": "acetyl-CoA + dihydroxyacetone phosphate = 3-hydroxy-2,4-dioxopentyl phosphate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.245", "l": "\"3-hydroxy-5-phosphooxypentane-2,4-dione thiolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800334", "l": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102495", "l": "GA5 3beta-hydroxylase activity", "d": ["Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate = gibberellin A3 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75434", "l": "32-hydroxyeburicol + O2 + reduced [NADPH--hemoprotein reductase] <=> 32-oxoeburicol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952639", "l": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35703", "l": "1'-hydroxyversicolorone + H(+) + NADPH + O2 = (2S,3S)-versiconal hemiacetal acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19960", "l": "2 5'-dehydroinosine + O2 <=> 2 9-riburonosylhypoxanthine + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57541", "l": "a 5'-end NTP-ribonucleotide-RNA + H2O => a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22137", "l": "7(1)-hydroxychlorophyllide a + H(+) + NADPH + O2 => chlorophyllide b + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78960", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + H2O => 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14732", "l": "beta-D-fructose 1,6-bisphosphate <=> D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70907", "l": "(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate = (2R)-3-phosphoglycerate + alpha-D-mannose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50679", "l": "H(+) + H2O + N-terminal L-asparaginyl-[protein] <=> N-terminal L-aspartyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54863", "l": "(2E)-geranial + H(+) + NADPH + O2 <=> (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023909", "l": "C3PO hydrolyzes cleaved passenger strand (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56740", "l": "a globoside Gb3Cer + UDP-alpha-D-galactose = a globoside GalGb3Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799409", "l": "HIPK2 phosphorylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.002057648751858", "identifiers": [{"i": "GO:0030546", "l": "signaling receptor activator activity", "d": ["The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31361", "l": "aminodiacetate + FMN + glyoxylate + H2O => FMNH2 + nitrilotriacetate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876262", "l": "EPS15 and HGS bind CBL-monoubiquitinated MET engaged with Listeria InlB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428664", "l": "SGPP1,2 dephosphorylate sphingoid-1-phosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31471", "l": "beta-D-gentiobiosyl crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190520", "l": "Association of Golgi  transport vesicles with microtubules (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160182", "l": "nitrate reductase (quinone) activity", "d": ["Catalysis of the reaction: a quinol + nitrate = a quinone + H2O + nitrite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5668605", "l": "RAC2:GTP binds NOX2 complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429699", "l": "CERT1-2 complex binds ceramide (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17506", "l": "H2O + N-(long-chain fatty acyl)ethanolamine => a long-chain fatty acid + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1655851", "l": "S2P hydrolyzes SREBP1A,1C,2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015492", "l": "phenylalanine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57676", "l": "4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] = 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6784861", "l": "HSPG binds LPL dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9831057", "l": "Expression of SALL1 in metanephric mesenchyme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77181", "l": "CO2 + H2O + uridine-5'-carboxamide => (5'S,6'R)-C-glycyluridine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24039", "l": "a ribonucleoside 5'-phosphate + ATP <=> a ribonucleoside 5'-diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58915", "l": "ATP + H2O + iron(III) dicitrate(out) <=> ADP + H(+) + iron(III) dicitrate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5691108", "l": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63315", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 <=> 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22285", "l": "2 H(+) + H2O + N-carbamoylputrescine => CO2 + NH4(+) + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035663", "l": "Toll-like receptor 2 binding", "d": ["Binding to a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035484", "l": "adenine/adenine mispair binding", "d": ["Binding to a double-stranded DNA region containing an A/A mispair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106357", "l": "glycerol-1-phosphate dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADH."], "t": []}, {"i": "RHEA:21412", "l": "NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10430", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4084976", "l": "NANS converts ManNAc-6-P to Neu5Ac-9-P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21349", "l": "8 H(+) + 10 malonyl-CoA => 10 CO2 + 10 CoA + 2 H2O + tetracenomycin F2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64419", "l": "D-xylofuranose + NADP(+) <=> D-xylono-1,4-lactone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22831", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + H2O <=> 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.119", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-140851", "l": "fibrin multimer -> fibrin multimer, crosslinked + NH4+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-166041", "l": "Transfer of LPS onto TLR4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162836", "l": "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19649", "l": "ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)", "d": [], "t": []}, {"i": "EC:6.1.1.12", "l": "\"aspartate--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55548", "l": "N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6),N(6)-dimethyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003864", "l": "3-methyl-2-oxobutanoate hydroxymethyltransferase activity", "d": ["Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655823", "l": "Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.3", "l": "\"omega-amidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9036008", "l": "Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482598", "l": "1-acyl LPI is acylated to PI by MBOAT7 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59135", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP <=> AMP + diphosphate + H(+) + staphyloferrin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10322", "l": "1-pyrroline-2-carboxylate + H2O => trans-3-hydroxy-L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63759", "l": "flavokermesate + UDP-alpha-D-glucose <=> flavokermesate 7-C-beta-D-glucoside + 2 H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64106", "l": "1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein] => 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14847", "l": "(S)-2,3-dihydrodipicolinate + H(+) + 2 H2O => L-aspartate 4-semialdehyde + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-210974", "l": "Interaction of SOS-1 to Tie2 bound  Grb2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77847", "l": "N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-tyrosine + O2 = (2S)-3-(4-hydroxyphenyl)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]propanoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102587", "l": "cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-O-(glucosyl)-p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoylglucose glucosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-[2''-O-(2'''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + 1-O-sinapoyl-beta-D-glucose = cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + trans-sinapate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851044", "l": "BTN1A1 binds xanthine oxidoreductase (XDH) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373729", "l": "Neurofascin binds Ankyrin-G (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34179", "l": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide = D-glucuronate + H(+) + mycophenolate", "d": [], "t": []}, {"i": "EC:3.1.1.93", "l": "\"mycophenolic acid acyl-glucuronide esterase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-351208", "l": "Spermidine  => N-acetylated spermidine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36074", "l": "6-tuliposide A <=> D-glucose + tulipalin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43167", "l": "7-cyano-7-deazaguanine + guanosine(15) in tRNA <=> 7-cyano-7-carbaguanosine(15) in tRNA + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48367", "l": "beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer + GDP-beta-L-fucose <=> beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28082", "l": "(2S)-ethylmalonyl-CoA + NADP(+) = (2E)-butenoyl-CoA + CO2 + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.85", "l": "\"crotonyl-CoA carboxylase/reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58625", "l": "N-dodecanoyl-(2S)-hydroxyglycine => dodecanamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29802", "l": "ATP + D-allose(out) + H2O <=> ADP + D-allose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665999", "l": "MKL1 translocates from cytosol to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.1.9", "l": "\"ferric-chelate reductase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0008112", "l": "nicotinamide N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-164651", "l": "Electron transfer from ubiquinol to cytochrome c of complex III (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65735", "l": "2-oxoglutarate + heptyl sulfate + O2 <=> CO2 + H(+) + heptanal + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52852", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] = 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin]", "d": [], "t": []}, {"i": "EC:1.14.14.46", "l": "\"pimeloyl-[acyl-carrier protein] synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190245", "l": "FGFR1b binds to FGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5655483", "l": "USP1 autocleavage (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474184", "l": "DHNTP is dephosphorylated by PTPS to PTHP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-688137", "l": "RIP2 is K63 polyubiquitinated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66125", "l": "2-oxobutanoate + L-histidine => (2S)-2-aminobutanoate + 3-(imidazol-5-yl)pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-191382", "l": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58269", "l": "[protein]-C-terminal glycine + NAD(+) => [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39284", "l": "a long-chain fatty acid(out) => a long-chain fatty acid(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44885", "l": "a cardiolipin + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68961", "l": "7,8-dihydroxycoumarin + S-adenosyl-L-methionine => 7-hydroxy-8-methoxycoumarin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008579", "l": "JUN kinase phosphatase activity", "d": ["Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36916", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017124", "l": "SH3 domain binding", "d": ["Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53907", "l": "ATP + L-threonyl-[tau protein] <=> ADP + H(+) + O-phospho-L-threonyl-[tau protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-211988", "l": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-177784", "l": "ribose 5-phosphate <=> D-ribulose 5-phosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59019", "l": "4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + NAD(+) <=> CO2 + cycloeucalenone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022405", "l": "ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-482621", "l": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62606", "l": "7-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381135", "l": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433428", "l": "GRB2 is indirectly recruited to p-KIT through SHP2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193981", "l": "CYP21A2 oxidises 17HPROG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12551", "l": "2-cis,4-trans-xanthoxin + NAD(+) <=> 2-cis-(+)-abscisic aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71996", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O => diphosphate + preaspterpenacid acid I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.11.61", "l": "\"linolenate 9R-lipoxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50628", "l": "a 2-(omega-methylsulfanyl)alkylmalate = a 3-(omega-methylsulfanyl)alkylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38035", "l": "(2Z,4Z)-2-hydroxyhepta-2,4-diene-1,7-dioate = (4Z)-2-oxohept-4-enedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876319", "l": "SLC50A1 transports Glc from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13460", "l": "3-methyl-2-oxobutanoate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] <=> CO2 + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007759", "l": "MSX2 binds RUNX2 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18812", "l": "L-alanine + oxomalonate <=> aminomalonate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20208", "l": "methylazoxymethanol + UDP-alpha-D-glucose <=> cycasin + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1564142", "l": "Collagen type IV degradation by MMP2,3,4,9,10,12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18815", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate => (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-380272", "l": "Plk1-mediated phosphorylation of Nlp (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17023", "l": "L-alanine + phosphonoacetaldehyde => (2-aminoethyl)phosphonate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64200", "l": "an N-(fatty acyl)-L-leucine + H2O = a fatty acid + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28387", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine => di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69765", "l": "a medium chain fatty acid + 2 H(+) + NADH => a medium-chain fatty aldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67481", "l": "2-oxoglutarate + O2 + prekainate => CO2 + H2O + kainate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36903", "l": "7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.290", "l": "\"tRNA(Phe) [7-(3-amino-3-carboxypropyl)wyosine(37)-O]-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878054", "l": "HIPK2 phosphorylates RUNX1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2046088", "l": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036456", "l": "L-methionine-(S)-S-oxide reductase activity", "d": ["Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O."], "t": []}, {"i": "RHEA:19995", "l": "[thioredoxin]-dithiol + L-methionine (S)-S-oxide => [thioredoxin]-disulfide + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9648268", "l": "HTR1A binds HTR1A antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65609", "l": "(4R)-hydroxysphinganine + docosanoyl-CoA => CoA + H(+) + N-docosanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4167511", "l": "HLCS biotinylates ACACB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31109", "l": "(2-hydroxyphenyl)acetate + CO2 => 3-phenylpyruvate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37047", "l": "H(+)(out) + L-histidine(out) = H(+)(in) + L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29788", "l": "ATP + glutathione(in) + H2O => ADP + glutathione(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9011949", "l": "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682011", "l": "LC3 binds ATG7 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428531", "l": "Recruitment of PAK to NCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62525", "l": "cytidine(839) in 12S rRNA + S-adenosyl-L-methionine => H(+) + N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-217258", "l": "FMO2:FAD:Mg2+ S-oxidises MTZ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352921", "l": "1,3-bisphosphoglycerate + NADH + H+ <=> glyceraldehyde 3-phosphate + NAD+ + phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8956659", "l": "ABL1 phosphorylates YAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45722", "l": "N-hexadecanoylsphing-4-enine(out) => N-hexadecanoylsphing-4-enine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6799959", "l": "PGLYRP3,4 binds bacterial peptidoglycan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9701524", "l": "STAT3 is phosphorylated downstream of active ALK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24489", "l": "H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] => (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696627", "l": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28020", "l": "2 H(+) + 3 N-(2,3-dihydroxybenzoyl)-L-serine => enterobactin + 3 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0031127", "l": "alpha-(1,2)-fucosyltransferase activity", "d": ["Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193964", "l": "CYP21A2 21-hydroxylates PROG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3322014", "l": "Autoglucosylation of GYG2 complexed with GYS2-a (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20074", "l": "D-allo-threonine => acetaldehyde + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203946", "l": "PDK isozymes phosphorylate PDHC subunit E1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30236", "l": "H2O + L-glutamate 5-semialdehyde + NAD(+) => 2 H(+) + L-glutamate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42301", "l": "a fatty acyl-[ACP] + sn-glycerol 3-phosphate => a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75580", "l": "A + cyathatriol => AH2 + cyathin A3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22718", "l": "(24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => cholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018868", "l": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798258", "l": "PRTPRF, PTPRS, PTPRD bind LRRC4B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50717", "l": "dimethyl sulfone + FMNH2 + O2 => FMN + formaldehyde + 2 H(+) + H2O + methanesulfinate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12061", "l": "acetyl-CoA + 5 H(+) + 6 malonyl-CoA => 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014434", "l": "RHOG GAPs stimulate RHOG GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42192", "l": "(9Z)-pentadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-pentadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114671", "l": "vWF binds to collagen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17733", "l": "acetylenedicarboxylate + H(+) + H2O = CO2 + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.1.78", "l": "\"acetylenedicarboxylate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38222", "l": "(9Z)-octadecenoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol <=> 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67925", "l": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate => 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40478", "l": "1,2,3-tributanoylglycerol + H2O <=> butanoate + dibutanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76073", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out) => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654148", "l": "p-4Y-PLCG1 dissociates from activated FGFR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56896", "l": "a carboxylate + ATP + H(+) = an acyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66161", "l": "hexanoyl-CoA + tyramine => CoA + H(+) + N-hexanoyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.841068507151263", "identifiers": [{"i": "GO:0022824", "l": "transmitter-gated monoatomic ion channel activity", "d": ["Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62835", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate <=> GDP + H(+) + methyl 8-{[alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-139895", "l": "tBID activates BAK protein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2213240", "l": "Reduction of disulphide bonds in MHC II antigens (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69196", "l": "ATP + L-glutamate + L-glutamyl-[beta-tubulin] = ADP + gamma-L-glutamyl-L-glutamyl-[beta-tubulin] + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33911", "l": "an N-alkylglycine + H2O + O2 = an alkylamine + glyoxylate + H2O2", "d": [], "t": []}, {"i": "EC:1.5.3.20", "l": "\"N-alkylglycine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5690565", "l": "SCD desaturates ST-CoA to OLE-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22685", "l": "4-amino-L-phenylalanyl-[peptidyl-carrier protein] + AH2 + O2 => (2R)-2-(4-aminophenyl)-L-seryl-[peptidyl-carrier protein] + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021609", "l": "ESR-associated SRC autophosphorylates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008928", "l": "mannose-1-phosphate guanylyltransferase (GDP) activity", "d": ["Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H+ = GDP-alpha-D-mannose + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358791", "l": "Phosphorylation of USP8 by P-AKT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047616", "l": "acyl-CoA dehydrogenase (NADP+) activity", "d": ["Catalysis of the reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693599", "l": "Association of Ku heterodimer with ends of DNA double-strand break (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18927", "l": "D-glucurono-3,6-lactone + H(+) + NADPH => L-gulono-1,4-lactone + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57875", "l": "(E)-2,4-dihydroxycinnamoyl-CoA <=> CoA + umbelliferone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8850992", "l": "Proteasome degrades polyubiquitinated PTEN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70743", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48069", "l": "a ganglioside GM2 (d18:1(4E)) + H2O => a ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828027", "l": "SOX17, TFAP2C, and PRDM1 (BLIMP1) bind the NANOS3 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866405", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2161701", "l": "PGH2 is isomerised to PGD2 by HPGDS (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62762", "l": "4alpha-formyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234167", "l": "Formation of HIF:CBP:p300 complex at promoters (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103054", "l": "gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A15-forming)", "d": ["Catalysis of the reaction: gibberellin A12 + O2 + 2-oxoglutarate = gibberellin A15 + carbon dioxide + succinate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1169397", "l": "Activation of ISG15 by UBA7 E1 ligase (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10333", "l": "a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654672", "l": "CBL ubiquitinates FRS2 and FGFR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71059", "l": "L-arginine(in) + L-leucine(out) = L-arginine(out) + L-leucine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9707516", "l": "FeHM dissociates from MetHb (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77070", "l": "H2O + NADP(+) + pentylamine <=> H(+) + NADPH + NH4(+) + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74733", "l": "Insulin receptor de-phosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106211", "l": "inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H+ + phosphate."], "t": []}, {"i": "RHEA:59500", "l": "5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46595", "l": "alfacalcidol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> calcitriol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69140", "l": "RPA binds to the Flap (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0004715", "l": "non-membrane spanning protein tyrosine kinase activity", "d": ["Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1614605", "l": "Persulfide sulfur is dioxygenated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69043", "l": "(2S)-2-nitrosobutanedioate + H(+) + NADPH + O2 <=> 2-nitrobutanedioate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56046", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.213", "l": "\"galactan exo-1,6-beta-galactobiohydrolase (non-reducing end)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676134", "l": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66862", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate => dimethylallyl diphosphate + 4 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9856502", "l": "mito-STARD7 transports Q10 to outer mitochondrial membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805109", "l": "CDK2 phosphorylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654569", "l": "Activated FGFR1 binds FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9701055", "l": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34979", "l": "H(+)(in) = H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8869667", "l": "oxLDL:CD36 binds TLR4:TLR6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56785", "l": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O => (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-170674", "l": "Dissociation of the Gi alpha:G olf complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52802", "l": "AMP + CoA + diphosphate + 2 H(+) + tenuazonic acid => acetoacetyl-CoA + ATP + L-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-186800", "l": "PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950771", "l": "Expression of SOD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-163798", "l": "Furin cleaves pro-protein Z to protein Z (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990136", "l": "linoleate 9S-lipoxygenase activity", "d": ["Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73641", "l": "CTP(in) + ITP(out) => CTP(out) + ITP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654646", "l": "Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34035", "l": "O2 + paromamine = 6'-oxoparomamine + H2O2", "d": [], "t": []}, {"i": "EC:1.1.3.43", "l": "\"paromamine 6'-oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390886", "l": "HRH4 binds Hist (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788623", "l": "p-Y-STATs translocate to nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8849638", "l": "Dissociation of the SPINK5:KLK5 complex at low pH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047964", "l": "glyoxylate reductase (NADH) activity", "d": ["Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65977", "l": "7-dehydrocholesterol + hnu => previtamin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21925", "l": "3-dehydro-L-gulonate + NAD(+) => 2,3-dioxo-L-gulonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29635", "l": "D-maltopentaose + H2O = alpha-D-glucose + D-maltotetraose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013435", "l": "RHOD auto-activates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-933531", "l": "Translocation of p-IRF7:p-IRF7 to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8985943", "l": "p-Y701-STAT1 dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49854", "l": "(2E)-octenoyl-CoA => (3E)-octenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66435", "l": "H(+)(out) + L-galactose(out) <=> H(+)(in) + L-galactose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9013198", "l": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56038", "l": "beta-D-mannose + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2,3) => H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B1)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41151", "l": "1-hexadecanoyl-2-[9-hydroperoxy-(10E-octadecenoyl)]-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + 9-hydroperoxy-10E-octadecenoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418091", "l": "F2R binds ARRB1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35344", "l": "3-hydroxydocosanoyl-CoA + NADP(+) => 3-oxodocosanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28913", "l": "H(+)(in) + L-lysine(in) => H(+)(out) + L-lysine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65292", "l": "2 ATP + butan-2-one + 3 H2O + hydrogencarbonate = 3-oxopentanoate + 2 AMP + 4 H(+) + 4 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16820", "l": "6-phospho-D-gluconate + NADP(+) <=> 6-phospho-2-dehydro-D-gluconate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.3", "l": "\"kynureninase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661425", "l": "BIL:ALB dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28428", "l": "keto-D-fructose 6-phosphate => D-allulose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615872", "l": "RANBP2 SUMOylates HDAC4 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193722", "l": "TetraHCA is translocated from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.55", "l": "\"lytic starch monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22034", "l": "glyoxylate + oxaloacetate => 3-oxalomalate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8987132", "l": "IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676082", "l": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19046", "l": "acetyl-CoA + H2O + pyruvate => (3R)-citramalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9718379", "l": "GNRHR binds chemical antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63493", "l": "H(+) + menadione + NADPH => menadiol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9645524", "l": "ALPK1:ADP-heptose binds TIFA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031864", "l": "EP1 subtype prostaglandin E2 receptor binding", "d": ["Binding to an EP1 subtype prostaglandin E2 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28204", "l": "2 ATP + 2 H2O + protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin] => 2 ADP + chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9710101", "l": "CASP4, CASP5 cleave GSDMD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448632", "l": "IL34 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446692", "l": "IRAK1 binds to MYD88 within the IL1R complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375138", "l": "CDO binds BOC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42729", "l": "S-adenosyl-L-methionine + uridine(2791) in 21S rRNA => 2'-O-methyluridine(2791) in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76993", "l": "NADH + oxidized 2[4Fe-4S]-[ferredoxin] => H(+) + NAD(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45610", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-decanoyl ethanolamine => H2O + N-decanoyl-1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37978", "l": "H(+) + homogentisate + phytyl diphosphate <=> 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78586", "l": "acetyl-CoA + eicosanoyl-CoA <=> 3-oxodocosanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18290", "l": "(S,S)-tartrate => H2O + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-211919", "l": "CYP4F8 19-hydroxylates PGH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050648", "l": "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding", "d": ["Binding to 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78207", "l": "D-methionine + H2O + O2 = 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25976", "l": "(+)-epi-isozizaene + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (5S)-albaflavenol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57394", "l": "3-O-acetyl-4'-O-demethylpapaveroxine + H(+) => (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68716", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + germacrene D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15398", "l": "dichloromethane + H2O => 2 chloride + formaldehyde + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65707", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-3,6-dideoxy-alpha-D-mannose <=> alpha-D-Tyv-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5358510", "l": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875443", "l": "USP8 deubiquitinates LRIG1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8951428", "l": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140842", "l": "n fibrin monomers -> fibrin multimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51071", "l": "(2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + pyruvate <=> (3S,5R,10R,12S,14S,15R,16R)-3,5,10,14,15-pentahydroxy-12,16-dimethylicosan-2-one + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57987", "l": "(20S)-ginsenoside Rg3 + UDP-alpha-D-glucose <=> (20S)-ginsenoside Rd + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8854293", "l": "TBC1D10A (EPI64) binds ARF6:GTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617864", "l": "HOXD4 mRNA is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59317", "l": "D-cellobiose + O2 => D-cellobiono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9840488", "l": "PSAP(195-273) forms a dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.3.-", "l": "\"Linked to the hydrolysis of diphosphate\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-990489", "l": "Kinesin-13 is a dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6795473", "l": "PDPK1 phosphorylates SGK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74296", "l": "n H(+)(out) + serotonin(in) => n H(+)(in) + serotonin(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21320", "l": "A + D-sorbitol = AH2 + keto-L-sorbose", "d": [], "t": []}, {"i": "EC:1.1.99.21", "l": "\"D-sorbitol dehydrogenase (acceptor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6781814", "l": "USP19 deubiquitinates RNF123 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654618", "l": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60714", "l": "(+)-artemisinic aldehyde + H(+) + NADH => (+)-artemisinic alcohol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023163", "l": "Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-114552", "l": "Thrombin-activated PARs activate G12/13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28996", "l": "H(+)(out) + L-threonine(in) => H(+)(in) + L-threonine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661115", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050025", "l": "L-glutamate oxidase activity", "d": ["Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30960", "l": "9,9'-di-cis-zeta-carotene + a quinone => 7,9,9'-tri-cis-neurosporene + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8950179", "l": "IL12B translocates from the cytosol to the extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-981809", "l": "ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102224", "l": "GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose hydrolase/2-epimerase activity", "d": ["Catalysis of the reaction: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose + H2O = 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23521", "l": "acetyl-CoA + propanoate => acetate + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426086", "l": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5682026", "l": "MRN bound to shortened telomeres activates ATM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29212", "l": "H(+)(out) + inosine(in) => H(+)(in) + inosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222006", "l": "STK11 (LKB1) phosphorylates NUAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662986", "l": "MT2A binds copper (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043772", "l": "acyl-phosphate glycerol-3-phosphate acyltransferase activity", "d": ["Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48188", "l": "(9Z,12Z)-octadecadienoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49346", "l": "2,2-dihydroxyspirilloxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 2-hydroxyspirilloxanthin + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76862", "l": "3-aminopentane + H2O + NAD(+) <=> H(+) + NADH + NH4(+) + pentan-3-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389580", "l": "formyl-CoA + H2O => formate + CoASH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-76590", "l": "AMP + H2O => IMP + NH4+ (AMPD) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76470", "l": "2 H(+) + 2 NADPH + 2 O2 + tetracenomycin B2 <=> 8-demethyltetracenomycin C + H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5682377", "l": "LC3 de-lipidation by ATG4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-191352", "l": "HMGCR dimer reduces bHMG-CoA to MVA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50235", "l": "8 H(+) + heme b + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + CO + Fe(2+) + 3 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71173", "l": "H(+)(out) + L-cysteine(in) + Na(+)(in) => H(+)(in) + L-cysteine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-429529", "l": "Thrombin binding to GP1b:IX:V (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25800", "l": "H2O + N(1)-acetylspermine + O2 = 3-acetamidopropanal + H2O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427910", "l": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023860", "l": "Histone acetyltransferases are recruited to the TFF1 gene (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717182", "l": "L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP and GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730847", "l": "Hydrolysis of PIP2 by PLCG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266089", "l": "Discoidal HDL binds membrane-associated free cholesterol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6783939", "l": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64154", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP + H(+) => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59591", "l": "ATP + beta-alanine + L-ornithine <=> ADP + beta-alanyl-L-ornithine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.5.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035243", "l": "protein-arginine omega-N symmetric methyltransferase activity", "d": ["Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17329", "l": "(1R,2S,4R)-borneol + NAD(+) = (1R,4R)-camphor + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.198", "l": "\"(+)-borneol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877308", "l": "MADD exchanges GTP for GDP on RAB27 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74731", "l": "rhamnetin + S-adenosyl-L-methionine = 7,4'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5658195", "l": "Defective SLC5A5 does not cotransport Na+ with I- from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5610726", "l": "The IFT-A complex recruits TULP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163069", "l": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874194", "l": "MBTPS2 (S2P) cleaves CREB3L1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9624925", "l": "miR-33 binds to the 3'UTR of the ABCA1 mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.323", "l": "\"(+)-thujan-3-ol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008806", "l": "carboxymethylenebutenolidase activity", "d": ["Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694109", "l": "LIPC dimer hydrolyses TAG to DAG and FA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10646", "l": "(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(+) => 2-oxo-2H-pyran-4,6-dicarboxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11142", "l": "D-mannose 6-phosphate => alpha-D-mannose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868236", "l": "BAR domain proteins recruit dynamin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21378", "l": "(S)-4-hydroxymandelate + CO2 => 3-(4-hydroxyphenyl)pyruvate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50049", "l": "ATP + cholate(in) + H2O => ADP + cholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14756", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] <=> acetate + androst-4-ene-3,17-dione + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15642", "l": "H(+) + oxaloacetate => CO2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28237", "l": "L-glutamate 5-semialdehyde <=> (S)-1-pyrroline-5-carboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114553", "l": "Activation of conventional Protein Kinase C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60508", "l": "a guanosine in mRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.60", "l": "\"marinolic acid--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864412", "l": "TFAP2A,TFAP2C homodimers bind the CGA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59132", "l": "2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate + 2-oxoglutarate + ATP = AMP + diphosphate + H(+) + staphyloferrin B", "d": [], "t": []}, {"i": "EC:6.3.2.56", "l": "\"staphyloferrin B synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "50.940690768445585", "identifiers": [{"i": "GO:0033218", "l": "amide binding", "d": ["Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050692", "l": "DNA binding domain binding", "d": ["Binding to a protein's DNA binding domain (DBD)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27917", "l": "4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40808", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + H(+) + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482773", "l": "MLCL transports from the IM to the ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5659861", "l": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1605825", "l": "MT-MMPs are sorted to the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690319", "l": "UCHL1, UCHL3 cleave ubiquitin adducts (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75216", "l": "beta-L-fucose + NADP(+) => H(+) + L-fucono-1,5-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73655", "l": "(S)-nicotine + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + N-methylmyosmine", "d": [], "t": []}, {"i": "EC:1.4.2.2", "l": "\"nicotine dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60906", "l": "13-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate => (9Z,12Z,15Z)-octadecatrienoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-874087", "l": "SGT1 binds HSP90 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661474", "l": "Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72932", "l": "O2 + proatranorin IV + reduced [NADPH--hemoprotein reductase] => atranorin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5228992", "l": "ROCK1,ROCK2 are activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851908", "l": "Activated MET binds GAB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5669240", "l": "FLNA binds PAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11604", "l": "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + n acetyl-CoA = [O(7),N-diacetyl-alpha-D-neuraminosyl-(2->8)](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2161890", "l": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61845", "l": "solasodine + UDP-alpha-D-glucose => H(+) + solasodine 3-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52848", "l": "5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine = 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-445705", "l": "Release Of ADP From Myosin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56778", "l": "(+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59756", "l": "L-arginine + S-adenosyl-L-methionine = H(+) + N(omega)-methyl-L-arginine + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.381", "l": "\"arginine N(omega)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189423", "l": "PPO oxidises PPGEN9 to PRIN9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8950778", "l": "p-Y693-STAT4 dimerizes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9851407", "l": "FAM83B, (FAM83A, FAM83D) bind EGFR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69149", "l": "H2O + O2 + spermine => H2O2 + NH4(+) + spermine monoaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1067667", "l": "IL6 binds IL6R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5635860", "l": "GLI:SUFU translocates to the ciliary tip in response to Hh signaling (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2168881", "l": "Truncated Alpha-1-Microglobulin binds heme (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13882", "l": "a quinone + an aldehyde + H2O => a carboxylate + a quinol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33915", "l": "4-(methylamino)butanoate + H2O + O2 = H2O2 + methylamine + succinate semialdehyde", "d": [], "t": []}, {"i": "EC:1.5.3.21", "l": "\"4-methylaminobutanoate oxidase (methylamine-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23115", "l": "6-methylsalicylate + H(+) <=> 3-methylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033445", "l": "AGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes an AGU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140395", "l": "averantin hydroxylase activity", "d": ["Catalyzes the reaction: (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O2 = (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H2O. Involved in aflatoxin biosynthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8979996", "l": "LIPs hydrolyze TG to DAG and LCFA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-68917", "l": "Cdc45 associates with the pre-replicative complex at the origin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423672", "l": "CYP1A2, 3A4 oxidise AFB1 to AFNBO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2534365", "l": "Slo3 Potassium Transport (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5665868", "l": "AMPK (complex) phosphorylates ULK1 (complex) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50398", "l": "2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O => (2-aminobenzoyl)acetate + H(+) + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71753", "l": "2-oxoglutarate(in) + glutarate(out) => 2-oxoglutarate(out) + glutarate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.6.1.22", "l": "\"Bacillus subtilis ribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-77592", "l": "Cleavage of Intronless Pre-mRNA at 3'-end (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047529", "l": "2,3-dimethylmalate lyase activity", "d": ["Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77102", "l": "5-hydroxymethyl-dUMP + H2O <=> 2-deoxy-D-ribose 5-phosphate + 5-hydroxymethyluracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9007447", "l": "E2F6 forms the PRC1L4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008987", "l": "quinolinate synthetase A activity", "d": ["Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45575", "l": "[(1->4)-beta-D-mannuronosyl](n) <=> [alginate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60177", "l": "5-methylaminomethyl-2-(Se-phospho)selenouridine(34) in tRNA + H2O => 5-methylaminomethyl-2-selenouridine(34) in tRNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9815510", "l": "MIB2 binds CYLD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57934", "l": "beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate => beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730860", "l": "Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381713", "l": "Potassium voltage-gated channels close in reponse to PKA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004120", "l": "photoreceptor cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0050499", "l": "oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H."], "t": []}, {"i": "EC:1.20.1.-", "l": "\"With NAD(+) or NADP(+) as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624130", "l": "Myristoylated NPHP3 translocates into the ciliary membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015417", "l": "ABC-type polyamine transporter activity", "d": ["Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15148", "l": "D-maltose <=> alpha,alpha-trehalose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27439", "l": "glutathione amide disulfide + 2 H2O => 2 glutathione amide + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14034", "l": "H2O + sn-glycero-3-phospho-1D-myo-inositol => 1D-myo-inositol 1-phosphate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176631", "l": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59386", "l": "3-(4-aminophenyl)pyruvate + L-glutamate => 2-oxoglutarate + 4-amino-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202375", "l": "Recruitment of ITK to SLP-76 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10780", "l": "(2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140978", "l": "mitochondrial large ribosomal subunit binding", "d": ["Binding to a mitochondrial large ribosomal subunit."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855162", "l": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21702", "l": "1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate => 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632648", "l": "SMURF1/2 ubiquitinates PTCH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071111", "l": "cyclic-guanylate-specific phosphodiesterase activity", "d": ["Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20711", "l": "ATP + erythritol <=> ADP + D-erythritol 4-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60561", "l": "L-methionyl-[protein] + S-adenosyl-L-methionine => S-adenosyl-L-homocysteine + S-methyl-L-methionyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654575", "l": "Activated FGFR1 phosphorylates FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70386", "l": "3-oxosphinganine + hexadecanoyl-CoA <=> CoA + H(+) + N-hexadecanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54250", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6810376", "l": "ING2 binds PI5P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5691512", "l": "APEH hydrolyses NAc-Ser-protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578910", "l": "KCNK dimers transport K+ from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.412913366396666", "identifiers": [{"i": "GO:0019899", "l": "enzyme binding", "d": ["Binding to an enzyme, a protein with catalytic activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733495", "l": "Viral Spike Binds to ACE2 on Uninfected Cell (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9668904", "l": "Formation of the CTF18 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0061459", "l": "L-arginine transmembrane transporter activity", "d": ["Enables the transfer of L-arginine from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30740", "l": "1D-myo-inositol 3-phosphate + H2O => myo-inositol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204008", "l": "SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193668", "l": "p75NTR and RHOA-GDI interact (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-187959", "l": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9617370", "l": "α1-antagonists bind ADRA1A,B,D (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62807", "l": "2 7-demethylsiderin + NADPH + O2 <=> desertorin A + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65221", "l": "(1S,2S)-1,2-dihydrobenzene-1,2-diol + NADP(+) => catechol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58816", "l": "ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": [], "t": []}, {"i": "EC:6.3.2.53", "l": "\"UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5159250", "l": "ATF7IP binds SETDB1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70268", "l": "hydrogencarbonate(in) + Na(+)(in) => hydrogencarbonate(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390427", "l": "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21071", "l": "A + H2O + nitrite <=> AH2 + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26421", "l": "(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 <=> (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75528", "l": "(R)-N-acetyl-S-benzyl-L-cysteine sulfoxide + FMNH2 + O2 => benzaldehyde + FMN + H(+) + H2O + N-acetyl-S-hydroxy-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047500", "l": "(+)-borneol dehydrogenase activity", "d": ["Catalysis of the reaction: (+)-borneol + NAD+ = (1R, 4R)-camphor + H+ + NADH."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-139893", "l": "Granzyme-B activates BID by cleavage (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12013", "l": "ATP + thiamine => ADP + H(+) + thiamine phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57607", "l": "a 1-tetracosanoyl-2-acyl-phosphoglycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a 1-[(15Z)-tetracos-15-enoyl]-2-acyl-phosphoglycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102052", "l": "indole-3-acetyl-proline synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-proline + ATP(4-) = H+ + indole-3-acetyl-proline + AMP(2-) + diphosphoric acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874849", "l": "CREBRF binds CREB3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33702", "l": "C20 sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57627", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] <=> 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9853369", "l": "PLK1 phosphorylates FIRMM at S744 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28838", "l": "citrate(out) + succinate(in) <=> citrate(in) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69142", "l": "Recruitment of Dna2 endonuclease (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102821", "l": "bixin methyltransferase activity", "d": ["Catalysis of the reaction: bixin + S-adenosyl-L-methionine = bixin dimethyl ester + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43654", "l": "3-oxododecanoyl-[ACP] + CO2 + CoA => decanoyl-CoA + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26136", "l": "H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8877451", "l": "MON1:CCZ1 exchanges GTP for GDP on RAB7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45273", "l": "12-phosphooxy-(9Z)-octadecenoate + H2O => 12-hydroxy-(9Z)-octadecenoate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9833973", "l": "ISGylation of PKR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5684261", "l": "MAP3K8 is phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78699", "l": "a 3-O-beta-D-glucosyl-beta-D-glucuronoside + phosphate = a beta-D-glucuronoside + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72627", "l": "2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65744", "l": "2-oxoglutarate + decyl sulfate + O2 = CO2 + decanal + H(+) + succinate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9842833", "l": "SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4411373", "l": "NLK translocates to nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-162798", "l": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352103", "l": "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47910", "l": "6-deoxy-6-sulfo-D-gluconate + H(+) => 6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-879594", "l": "SLCO4C1 mediates the transport of digoxin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64678", "l": "butyl 3-(methylsulfanyl)propanoate + CoA => 3-(methylsulfanyl)propanoyl-CoA + butan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2162253", "l": "PDSS1,2 ligates FPP to IPPP (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1296045", "l": "Activation of Potassium transport channels (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0072349", "l": "modified amino acid transmembrane transporter activity", "d": ["Enables the transfer of modified amino acids from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851890", "l": "MET phosphorylates SHC1-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-190263", "l": "FGFR3b binds to FGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.19", "l": "\"[protein ADP-ribosylarginine] hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55877", "l": "apo-[aequorin] + coelenterazine => apo-[aequorin]--coelenterazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65056", "l": "glycochenodeoxycholate + NADP(+) = 7-oxoglycolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16688", "l": "di-trans,poly-cis-dolichol + hexadecanoyl-CoA <=> a dolichyl hexadecanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57942", "l": "CO2 + 2 H2O + harderoheme III => Fe-coproporphyrin III + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61531", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base <=> a diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52685", "l": "NAD(+) + pyridoxine => H(+) + NADH + pyridoxal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-453104", "l": "Phosphorylated SHC1 recruits GRB2:GAB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27292", "l": "AH2 + CO2 => A + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62633", "l": "a hydroperoxide + 2 glutathione => an alcohol + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-548814", "l": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830872", "l": "G is N-glycosylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18159", "l": "ADP + H(+) + phosphoenolpyruvate => ATP + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602549", "l": "Defective TLR3 does not bind viral dsRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3323111", "l": "Cytoslic carboxylases translocate to mitochondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30788", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (6R)-L-erythro-6,7-dihydrobiopterin + H2O + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59448", "l": "dodecan-1-ol + NADP(+) = dodecanal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78587", "l": "eicosanoyl-CoA + O2 = (2E)-eicosenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27521", "l": "H2O + sphing-4-enine 1-phosphate <=> phosphate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16097", "l": "acetylpyruvate + H2O = acetate + H(+) + pyruvate", "d": [], "t": []}, {"i": "EC:3.7.1.6", "l": "\"acetylpyruvate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1470012", "l": "Disassociation and translocation of STATs to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40649", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23938", "l": "5-dehydro-D-gluconate + H(+) + NADPH => D-gluconate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-844438", "l": "NLRP1 oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9718394", "l": "GNRHR binds GNRHR peptide antagonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49972", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-390597", "l": "Release Of ADP From Myosin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749494", "l": "IKBIP binds IKBKB and CHUK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950731", "l": "CRLF1:IL27 translocates to the extracellular region (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5099899", "l": "WNT5A binds FZD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46252", "l": "a (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75096", "l": "Docking of the TAP:EJC Complex with the NPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5660660", "l": "p300 acetylates RELA subunit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66949", "l": "acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate => alpha-L-2OAcRha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30905", "l": "H(+) + S-adenosyl-L-homocysteine + spheroidene => demethylspheroidene + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-392143", "l": "NO binds to Guanylate Cyclase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58649", "l": "rifamycin SV hemiaminal => H(+) + rifamycin SV ortho-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54270", "l": "(3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + CO2 + succinate => 2-oxoglutarate + L-asparaginyl-[hypoxia-inducible factor alpha subunit] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1299338", "l": "Activation of TRESK (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60066", "l": "a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + H2O + NAD(+) => a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25347", "l": "D-tyrosyl-tRNA(Tyr) + H2O = D-tyrosine + tRNA(Tyr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373724", "l": "Nephrin binds NCK (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-437999", "l": "Phosphorylation of MKK4 by activated TAK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158795", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45262", "l": "tetracosanoate(in) => tetracosanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41186", "l": "1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-octadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-933527", "l": "Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8951951", "l": "RUNX3 binds EP300 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47723", "l": "H(+) + H2O + isoguanine <=> NH4(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4085994", "l": "TOPORS SUMOylates SIN3A with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16039", "l": "2-deoxy-alpha-D-ribose 1-phosphate + thymine => phosphate + thymidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56265", "l": "CMP-N-acetyl-beta-neuraminate + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] => CMP + H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14590", "l": "luteolin + S-adenosyl-L-methionine => chrysoeriol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16488", "l": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + imidazole-4-acetate <=> 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + diphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50441", "l": "prostaglandin H1 => prostaglandin D1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418553", "l": "cAMP degradation by Phosphodiesterases (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2574845", "l": "AJUBA binds centrosome-associated AURKA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39023", "l": "an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.042693372152272", "identifiers": [{"i": "GO:0019956", "l": "chemokine binding", "d": ["Binding to a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052622", "l": "ATP dimethylallyltransferase activity", "d": ["Catalysis of the reaction: delta(2)-isopentenyl diphosphate + ATP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-triphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42980", "l": "L-tyrosine = 2-aminoprop-2-enoate + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69455", "l": "3beta-hydroxy-5-androstene-7,17-dione + H(+) + NADPH <=> 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59628", "l": "H2O + N(2)-(4-aminobutanoyl)-L-arginine = 4-aminobutanoate + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66257", "l": "ATP + H(+) + IC-asc-C7 => diphosphate + IC-asc-C7-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047278", "l": "bilirubin-glucuronoside glucuronosyltransferase activity", "d": ["Catalysis of the reaction: 2 bilirubin-glucuronoside = bilirubin + bilirubin-bisglucuronoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1237119", "l": "Acireductone is oxidized to MOB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5227009", "l": "ABCF1 binds EIF2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9653514", "l": "USP17L2 deubiquitinates RCE1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53837", "l": "a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine => a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49152", "l": "dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-376851", "l": "SLC25A11 exchanges 2-OG and MAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008437", "l": "thyrotropin-releasing hormone activity", "d": ["The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0042947", "l": "glucoside transmembrane transporter activity", "d": ["Enables the transfer of glucosides from one side of a membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-354060", "l": "Translocation of RIAM to plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043825", "l": "succinylornithine transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2430535", "l": "MASTL phosphorylates ENSA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948136", "l": "ULK1 Translocates to the mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33349", "l": "glyoxylate + NH4(+) => 2-iminoacetate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706345", "l": "Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9667965", "l": "ANKLE2 binds PP2A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9766677", "l": "MAP1LC3B binds KEAP1 and SQSTM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74227", "l": "H2O + L-threonyl-tRNA(Ile) = L-threonine + tRNA(Ile)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40722", "l": "an R-cob(III)alamin + apo-[alkylcobalamin reductase] + glutathione <=> an S-substituted glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603067", "l": "Unknown nuclease cleaves pre-piRNA in ASZ1:DDX4:MOV10L1:6xMeR-PIWIL2:pre-piRNA:TDRD1:TDRD12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-447252", "l": "IL12RB1:TYK2 binds IL12RB2:JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53853", "l": "glycocholate + NAD(+) => 7-oxo-glycodeoxycholate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051264", "l": "mono-olein transacylation activity", "d": ["Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55732", "l": "19-(4-hydroxyphenyl)nonadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = 19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44004", "l": "3-methyl fatty acid + ATP + CoA = a 3-methyl fatty acyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56707", "l": "(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + H(+) + O2 <=> 3-[(E)-2-isocyanovinyl]indole + 2 CO2 + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8948034", "l": "FGR binds LDL:LRP8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31816", "l": "(2E,6E)-farnesyl diphosphate => (+)-(E)-beta-caryophyllene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57021", "l": "apulose + ATP => ADP + apulose 4-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8943780", "l": "SALL4 recruits NuRD to PTEN gene (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72084", "l": "ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O => ADP-alpha-D-ribose 1''-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3907292", "l": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651809", "l": "LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21070", "l": "AH2 + nitrate => A + H2O + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1472121", "l": "Phosphorylation of p-KIT on Y900 by Src kinases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73695", "l": "dADP(out) + H(+)(out) + phosphate(in) = dADP(in) + H(+)(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60146", "l": "ADP + gamma-L-glutamyl-L-glutamyl-[protein] + H(+) + phosphate => ATP + L-glutamate + L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71541", "l": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3266566", "l": "G6PC2 hydrolyzes G6P to form Glc and Pi (islet) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29086", "l": "(S)-malate + ubiquinone-8 <=> oxaloacetate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031818", "l": "P2Y9 nucleotide receptor binding", "d": ["Binding to a P2Y9 nucleotide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9678766", "l": "CYP3A4 binds CYP3A4 inhibitors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34299", "l": "2'-deamino-2'-hydroxyneamine + 2-oxoglutarate = 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.94", "l": "\"2'-deamino-2'-hydroxyneamine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75998", "l": "Formation of RAD52 heptameric ring structure complexes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-198440", "l": "SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9793472", "l": "RIPK3 binds p-S9-PRKN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448702", "l": "Caspase-1 active tetramer formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3247836", "l": "Retromer recycles WLS to the Golgi (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "62.771756552598255", "identifiers": [{"i": "GO:0003677", "l": "DNA binding", "d": ["Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66387", "l": "(2E,6E,10E,14E)-geranylfarnesol <=> scalar-17(25)-en-19-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45732", "l": "D-ribulose 5-phosphate + L-tyrosine = (2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + formaldehyde + H(+) + H2O + hydroxyacetone + phosphate", "d": [], "t": []}, {"i": "EC:4.1.99.24", "l": "\"L-tyrosine isonitrile synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010301", "l": "xanthoxin dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: NAD+ + xanthoxin = (+)-abscisic aldehyde + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047455", "l": "16-alpha-hydroxyprogesterone dehydratase activity", "d": ["Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2514772", "l": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53024", "l": "a plastoquinone + H2O + L-arginine = 5-guanidino-2-oxopentanoate + a plastoquinol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10095", "l": "a 2'-deoxyribonucleoside 3'-phosphate + H2O <=> a 2'-deoxyribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5323545", "l": "Canonical WNT signaling through the atypical receptor RYK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683384", "l": "UIMC1 and FAM175A bind DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3782655", "l": "HDAC10 deacetylates histone (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-193736", "l": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9696266", "l": "RND2 binds effectors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70577", "l": "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75091", "l": "2 chloride(in) + sulfate(out) = 2 chloride(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24082", "l": "AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp) => ATP + L-tryptophan + tRNA(Trp)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9646468", "l": "mTORC1 binds RHEB:GTP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196955", "l": "2xENPP1 hydrolyzes FAD to FMN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-212005", "l": "CYP2F1 dehydrogenates 3-methylindole (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-114558", "l": "Thrombin-activated PARs activate Gq (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70866", "l": "L-glutamine(out) + L-threonine(in) + Na(+)(out) <=> L-glutamine(in) + L-threonine(out) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64055", "l": "(13Z)-docosenoyl-CoA + (4R)-hydroxysphinganine <=> CoA + H(+) + N-(13Z-docosenoyl)-4R-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9706399", "l": "RHOBTB3 hydrolyzes ATP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5205649", "l": "p62 links damaged mitochondria to LC3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449811", "l": "IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19247", "l": "2-aminophenol => N-phenylhydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16489", "l": "(R)-prunasin + H2O = D-glucose + mandelonitrile", "d": [], "t": []}, {"i": "EC:3.2.1.118", "l": "\"prunasin beta-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018114", "l": "threonine racemase activity", "d": ["Catalysis of the reaction: L-threonine = D-threonine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193060", "l": "CYP19A1 hydroxylates ANDST to E1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-508473", "l": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114577", "l": "Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71796", "l": "(R)-3-hydroxybutanoate(out) + H(+)(out) => (R)-3-hydroxybutanoate(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-381109", "l": "IRE1 binds IRE1 forming dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-451418", "l": "Pellino ubiquitinates IRAK1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42477", "l": "2,2',3-trihydroxydiphenyl ether + H(+) + O2 => 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.940402076938994", "identifiers": [{"i": "GO:0008276", "l": "protein methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group (CH3-) to a protein."], "t": []}, {"i": "REACT:R-HSA-9632182", "l": "PRMT1 methylates ESRs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374207", "l": "G protein-coupled estrogen receptor 1 binds estrogen non-classically (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937016", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5685318", "l": "BCDX2 complex formation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73646", "l": "CTP(out) + IDP(in) <=> CTP(in) + IDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40954", "l": "(2S)-2-acetamido-4-aminobutanoate + H2O <=> acetate + L-2,4-diaminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36830", "l": "dioscin + 3 H2O <=> D-glucose + diosgenin + 2 L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76380", "l": "n H(+)(out) + L-histidine(out) => n H(+)(in) + L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.25.1", "l": "\"proteasome endopeptidase complex\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0090369", "l": "ornithine carbamoyltransferase inhibitor activity", "d": ["Binds to and stops, prevents, or reduces the activity of ornithine carbamoyltransferase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8852522", "l": "MST1 dimer:MST1R dimer binds MST1R dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36871", "l": "(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70727", "l": "3-(6-sulfo-alpha-D-quinovosyl)glycerol + H2O = 6-sulfo-alpha-D-quinovose + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917892", "l": "FLVCR1-1 transports heme from cytosol to extracellular region (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964619", "l": "PAK1 binds ARHGEF6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69091", "l": "butanal + H2O + NAD(+) <=> butanoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1295604", "l": "B-RAF dissociates from S111/S120 p-SPRY2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030290", "l": "sphingolipid activator protein activity", "d": ["Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20848", "l": "H(+) + O2 + phosphate + pyruvate = acetyl phosphate + CO2 + H2O2", "d": [], "t": []}, {"i": "EC:1.2.3.3", "l": "\"pyruvate oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5432852", "l": "SFTPA/SFTPD binds TLR4:LY96 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35904", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4641260", "l": "Ubiquitinated DVL1 is degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76690", "l": "(9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione <=> (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-388809", "l": "CTLA-4 binds B7-1/B7-2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.9", "l": "\"enteropeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676589", "l": "RANKL,sRANKL trimer binds RANK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42401", "l": "lactose(out) + N(pros)-phospho-L-histidyl-[protein] => L-histidyl-[protein] + lactose 6-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9758604", "l": "Ubiquitination of IKBKG by TRAF6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015167", "l": "arabitol transmembrane transporter activity", "d": ["Enables the transfer of an arabitol from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56210", "l": "3-O-[N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+) => CMP-N-acetyl-beta-neuraminate + O(3)-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12676", "l": "an aliphatic amide <=> a nitrile + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388814", "l": "Grb2 binds CD28 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9824582", "l": "MAPK1 phosphorylates SOX10 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29098", "l": "5 H(+)(in) + NADH + ubiquinone-8 <=> 4 H(+)(out) + NAD(+) + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62009", "l": "alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP-beta-L-fucose => alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56672", "l": "dihydro-4-coumaroyl-CoA + NADP(+) = (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102835", "l": "1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:3-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654625", "l": "Activated FGFR3 binds SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47918", "l": "ADP + H(+) + N-hexanoyl-(4R)-hydroxysphinganine-1-phosphate => ATP + N-hexanoyl-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5244692", "l": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2534365", "l": "Slo3 Potassium Transport (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14725", "l": "2 ATP + 2 cob(II)inamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)inamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66845", "l": "asperterpenoid A + O2 + reduced [NADPH--hemoprotein reductase] => asperterpenoid C + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40899", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31916", "l": "ATP + D-maltose => ADP + alpha-maltose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55244", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 = 4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6797554", "l": "ABP1 binds SHANK proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35890", "l": "1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA <=> 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53021", "l": "a plastoquinone + an L-alpha-amino acid + H2O => a 2-oxocarboxylate + a plastoquinol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8938829", "l": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25067", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) => (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50350", "l": "a dolichyl diphosphate + H(+) + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] => alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + L-asparaginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015663", "l": "nicotinamide mononucleotide transmembrane transporter activity", "d": ["Enables the directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163843", "l": "Furin cleaves pro-GAS6 to GAS6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953111", "l": "E2F6 binds TFDP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42867", "l": "norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine <=> H(+) + norspermine + S-methyl-5'-thioadenosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839053", "l": "AFG3L2:SPG7 binds SMDT1 (EMRE) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41690", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+) + propanoate => 1-O-hexadecyl-2-propanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11721", "l": "ATP + 2 H2O + N-methylhydantoin => ADP + 2 H(+) + N-carbamoylsarcosine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24903", "l": "3',3'-c-di-GMP + H2O => 5'-phosphoguanylyl(3'->5')guanosine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25550", "l": "abieta-8(14),12-diene + diphosphate => (+)-copalyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42286", "l": "(15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43019", "l": "an S-alkyl-L-cysteine <=> 2-aminoprop-2-enoate + an alkyl thiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-507719", "l": "p62:MEKK3 binds to TRAF6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75069", "l": "chloride(in) + 2 hydrogencarbonate(out) + Rb(+)(out) => chloride(out) + 2 hydrogencarbonate(in) + Rb(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670620", "l": "Defective DAXX does not bind ATRX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55944", "l": "2-chloroethanol + 2 Fe(III)-[cytochrome c] = chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66156", "l": "butanoyl-CoA + tyramine = CoA + H(+) + N-butanoyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1299304", "l": "Activation of tandem pore domain in a weak inwardly rectifying  K+ channels (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-749448", "l": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43419", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473152", "l": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29175", "l": "2 O2 + ubiquinol-8 = 2 H(+) + 2 superoxide + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71558", "l": "5-C(alpha)-glycyl-dTMP in DNA + H(+) <=> 5-aminoethyl-dUMP in DNA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50009", "l": "6-methylpretetramide + 2 H(+) + NADPH + O2 => 4-hydroxy-6-methylpretetramide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48925", "l": "a ganglioside GM4 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390673", "l": "CHRM2,4 bind acetylcholine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66404", "l": "ATP + glutathione(in) + H2O + taurocholate(in) = ADP + glutathione(out) + H(+) + phosphate + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74334", "l": "O-butanoyl-(R)-carnitine(in) <=> O-butanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9856718", "l": "HPDL dioxygenates HPPA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33945", "l": "4 H2O + 2 L-citrulline + 3 NAD(+) + 2 nitric oxide => H(+) + 2 L-arginine + 3 NADH + 4 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71155", "l": "TAT deaminates tyrosine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005457", "l": "GDP-fucose transmembrane transporter activity", "d": ["Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-110353", "l": "Displacement of MBD4 glycosylase by APEX1 at the AP site (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-157849", "l": "Formation of translation initiation complexes containing mRNA that does not circularize (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6809325", "l": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3371591", "l": "Trimerization of cytosolic HSF1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5675417", "l": "PEBP1 binds activated RAF1 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43721", "l": "juvenile hormone III carboxylate + S-adenosyl-L-methionine => juvenile hormone III + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9027043", "l": "CYPs hydroxylate DHA to 14(R)-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48474", "l": "a ganglioside GD1a + N-acetylneuraminate => a ganglioside GT1a + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59139", "l": "ATP + citrate + D-ornithine <=> AMP + diphosphate + H(+) + N(5)-[(S)-citryl]-D-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25856", "l": "(9Z)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (9Z,12Z)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75389", "l": "D-ribose 5-phosphate + queuine => H2O + queuosine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12052", "l": "(2E,6E)-farnesyl diphosphate = diphosphate + trichodiene", "d": [], "t": []}, {"i": "EC:4.2.3.6", "l": "\"trichodiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017797", "l": "NOTCH3 binds YBX1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4551768", "l": "PIAS4 SUMOylates PARP1 with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72159", "l": "glutarate(in) + taurocholate(out) = glutarate(out) + taurocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109529", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-114284", "l": "Release of Cytochrome c from mitochondria (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26166", "l": "4'-hydroxyechinenone + A + H2O => AH2 + echinenone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047921", "l": "aminoglycoside 2'-N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + gentamicin C(1a) = N(2')-acetylgentamicin C(1a) + CoA + H+. This is acetylation of the 2'-amino group of the 6-deoxy-6-aminoglucose ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015554", "l": "tartrate transmembrane transporter activity", "d": ["Enables the transfer of tartrate from one side of a membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610737", "l": "NUMB:ITCH bind and ubiquitnate GLI1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193424", "l": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15639", "l": "[alginate](n+1) + GDP + H(+) => [alginate](n) + GDP-alpha-D-mannuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-450406", "l": "p-S92,203-BRF1 binds 14-3-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71608", "l": "(S)-malate(in) + phosphate(out) => (S)-malate(out) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33706", "l": "(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA <=> CoA + H(+) + N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051392", "l": "tRNA N-acetyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N4-acetylcytidine in tRNA + CoA + H+ + phosphate."], "t": []}, {"i": "RHEA:53876", "l": "a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55833", "l": "cortisone + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxycortisone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40037", "l": "ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate => ATP + L-glutamate + N-acetyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1237045", "l": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32919", "l": "H2O + methyl (indol-3-yl)acetate = (indol-3-yl)acetate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55089", "l": "eburicol + S-adenosyl-L-methionine => (24Z)-ethylidenelanosterol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.30", "l": "\"coccolysin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54909", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH => (4E)-hexenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68083", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O <=> a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33219", "l": "ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.107", "l": "\"ent-kaurenoic acid monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9729300", "l": "Unknown kinase phosphorylates nucleoprotein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9751037", "l": "SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0072541", "l": "peroxynitrite reductase activity", "d": ["Catalysis of the reaction: [protein]-dithiol + ONOO- = [protein]-disulfide + NO2- + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-388981", "l": "The Kiss receptor GPR54 binds kisspeptin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27669", "l": "(R)-methylmalonyl-CoA + H(+) <=> CO2 + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879562", "l": "SLCO2B1 has a narrow substrate specificity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205262", "l": "Direct recruitment of PI3K to p-KIT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5138441", "l": "WNT5A-FZD4 recruits DVL2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71850", "l": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15641", "l": "H(+) + oxaloacetate = CO2 + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373716", "l": "DCC interacting NCK-1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8863463", "l": "STON2 binds SYT proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43967", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA <=> 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13101", "l": "4-imidazolone-5-propanoate = H2O + trans-urocanate", "d": [], "t": []}, {"i": "EC:4.2.1.49", "l": "\"urocanate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5368580", "l": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110219", "l": "Cleavage of thymine by TDG glycosylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48389", "l": "alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose => alpha-N-glycoloylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66830", "l": "2 adenosylcob(III)alamin + 2 diphosphate + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 phosphate => 2 ATP + 2 cob(II)alamin + 2 H2O + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47783", "l": "a cytidine in 25S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 25S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482862", "l": "PC is hydrolysed to 2-acyl LPC by PLA2[7] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008147", "l": "structural constituent of bone", "d": ["The action of a molecule that contributes to the structural integrity of bone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5662623", "l": "MT1F binds zinc (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22113", "l": "isoxazolin-5-one + O-acetyl-L-serine => 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72225", "l": "4-hydroxy-L-proline + chloride(in) + 2 Na(+)(in) => 4-hydroxy-L-proline(out) + chloride(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6807055", "l": "DHCR7 reduces 7-dehydroCHOL to CHOL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.3.16", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442273", "l": "VAV1 is a GEF for Rho/Rac family GTPases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62820", "l": "1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 1alpha,25-dihydroxy-2beta-(1,3-dihydroxypropoxy)-cholecalciferol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62505", "l": "3-amino-5-hydroxybenzoate + ATP + holo-[aryl-carrier protein] => 3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-450517", "l": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49156", "l": "dTDP-4-(methylamino)-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + S-adenosyl-L-methionine = dTDP-alpha-D-forosamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46785", "l": "a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34726", "l": "15-methylhexadecasphing-4-enine 1-phosphate + H2O <=> 15-methylhexadecasphing-4-enine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12427", "l": "(3S)-3-hydroxy-L-aspartate <=> NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.64", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16023", "l": "enol-oxaloacetate => oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5603467", "l": "Activated protein C is released from PROCR (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9824977", "l": "MAPK1-dependent phosphorylation of MITF-M (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.2.1.13", "l": "\"acetate--CoA ligase (ADP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2186771", "l": "RNF111 binds SMAD7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28007", "l": "H2O + N(alpha)-methyl-L-tryptophan + O2 => formaldehyde + H2O2 + L-tryptophan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50541", "l": "prostaglandin A2 => prostaglandin C2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19233", "l": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]", "d": [], "t": []}, {"i": "EC:3.1.2.22", "l": "\"palmitoyl-protein hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77256", "l": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53234", "l": "(24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => desmosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2002460", "l": "P4HB binds Collagen chains (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264444", "l": "Autoubiquitination of phospho-COP1(Ser-387 ) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67332", "l": "13-cis-retinal + H2O + NAD(+) = 13-cis-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:2001077", "l": "(1->3),(1->4)-beta-glucan binding", "d": ["Binding to (1->3),(1->4)-beta-glucan."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22469", "l": "GTP + 3 H2O => 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66345", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654422", "l": "Activated FGFR4 binds FRS2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78967", "l": "a 1,2-diacyl-sn-glycero-3-phosphoglycerol + H2O = a 1,2-diacyl-sn-glycerol + glycerol 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395764", "l": "atREs binds to nascent CM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63984", "l": "5-hydroxyuridine + ATP = 5-hydroxyuridine 5'-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46344", "l": "propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9033232", "l": "PEX7 binds cargo proteins containing PTS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9762345", "l": "PREDN:ALB dissociates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16168", "l": "L-tryptophan + O2 <=> CO2 + H2O + indole-3-acetamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031778", "l": "type 2 melanin-concentrating hormone receptor binding", "d": ["Binding to a type 2 melanin-concentrating hormone receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9690449", "l": "S1PR1 bind S1P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75288", "l": "glyoxylate(in) + sulfate(out) => glyoxylate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159358", "l": "SULT1A3,4 dimers sulfate DA to DAOS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868118", "l": "MAPK12 phosphorylates PTPN3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60218", "l": "CO2 + formaldehyde + N(6)-methyl-L-lysyl(4)-[histone H3] + succinate => 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.42", "l": "\"cathepsin O\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-428696", "l": "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48899", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + protochlorophyllide a <=> 3,8-divinyl protochlorophyllide a + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58341", "l": "beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O => chenodeoxycholate + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4641256", "l": "Ubiquitinated AXIN is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31995", "l": "(2E,6E)-farnesyl diphosphate = 7-epi-sesquithujene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.101", "l": "\"7-epi-sesquithujene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9842655", "l": "IRS1 recruits GRB2 to active LTK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106009", "l": "(4S)-4-hydroxy-2-oxoglutarate aldolase activity", "d": ["Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654402", "l": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42908", "l": "S-adenosyl-L-methionine + uridine(1939) in 23S rRNA = 5-methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.190", "l": "\"23S rRNA (uracil(1939)-C(5))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043719", "l": "2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity", "d": ["Catalysis of the reaction: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + O2 + H+ = 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78856", "l": "a medium-chain 2,3-saturated fatty acyl-CoA + O2 => a medium-chain (2E)-enoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-113411", "l": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52442", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29344", "l": "L-aspartate(in) + succinate(out) => L-aspartate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442368", "l": "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799179", "l": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73646", "l": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209840", "l": "Two DITs combine to form thyroxine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23652", "l": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)", "d": [], "t": []}, {"i": "EC:2.3.2.5", "l": "\"glutaminyl-peptide cyclotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74800", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9749647", "l": "CES2 hydrolyzes ASA- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706323", "l": "Active FLT3 binds to SLA2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201821", "l": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61116", "l": "(2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5649708", "l": "NEIL1,NEIL2 recruits POLB to incised AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1433456", "l": "Recruitment of STATs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9690449", "l": "S1PR1 bind S1P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46526", "l": "(5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14027", "l": "NH4(+) + xanthopterin-B2 => H(+) + H2O + sepiapterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59468", "l": "an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944254", "l": "Association of procollagen type XXVI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165766", "l": "Phosphorylation and activation of eIF4G by activated S6K1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78201", "l": "a 1,3-diacylglycerol + a 3beta-hydroxysteroid ester => a 3beta-hydroxysteroid + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033827", "l": "high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity", "d": ["Catalysis of the transfer of an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796342", "l": "MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010815", "l": "SLITs bind keratan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033782", "l": "24-hydroxycholesterol 7alpha-hydroxylase activity", "d": ["Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced [NADPH-hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized [NADPH-hemoprotein reductase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856525", "l": "ANGPTL8 binds ANGPTL3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018464", "l": "3-hydroxypimeloyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 3-hydroxypimelyl-CoA + NAD+ = 3-oxopimelyl-CoA + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "71.798022316275805", "identifiers": [{"i": "GO:0030594", "l": "neurotransmitter receptor activity", "d": ["Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59267", "l": "Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O <=> Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51445", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-leucine => H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193780", "l": "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78594", "l": "(3S)-hydroxyeicosanoyl-CoA <=> (2E)-eicosenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698013", "l": "PTPN11:p-STAT5 dissociates from mutant FLT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987202", "l": "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9693250", "l": "RHOD binds effectors at the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696119", "l": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362437", "l": "C-terminal Hh fragments are bound by lectins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0008266", "l": "poly(U) RNA binding", "d": ["Binding to a sequence of uracil residues in an RNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9836383", "l": "p-PKR dimer phosphorylates ILF3:ILF2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59809", "l": "L-tyrosine => D-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170087", "l": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20895", "l": "butanoyl-CoA + phosphate <=> butanoyl phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9604487", "l": "p-IRF7:p-IRF7 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174448", "l": "Formation of Processive Complex on the C-strand of the telomere (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22572", "l": "A + H2O + N-methyl-L-glutamate = AH2 + formaldehyde + L-glutamate", "d": [], "t": []}, {"i": "EC:1.5.99.5", "l": "\"methylglutamate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-909729", "l": "Activation of JAK kinases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45246", "l": "(2E,4E)-octadienoyl-CoA => (3E,5Z)-octadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-109343", "l": "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46726", "l": "(2R)-2-methyltetradecanoyl-CoA => (2S)-2-methyltetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018501", "l": "cis-chlorobenzene dihydrodiol dehydrogenase activity", "d": ["Catalysis of the conversion of a di- or tetrachlorinated dienol to the corresponding catechol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953499", "l": "IMPAD1 hydrolyses PAP to AMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607736", "l": "MALT1 oligomerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759169", "l": "p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663293", "l": "RORA, EP300 bind SREBF1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114307", "l": "Release of SMAC (DIABLO) from mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69556", "l": "D-glucose(out) + H(+)(out) = D-glucose(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34201", "l": "bracteatin 6-O-beta-glucoside + H2O => 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9653894", "l": "Expression of CHAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351215", "l": "Putrescine + dc-Adenosyl methionine  => Spermidine + 5'-methylthioadenosine (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50508", "l": "acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22052", "l": "A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine", "d": [], "t": []}, {"i": "EC:1.7.99.1", "l": "\"hydroxylamine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28343", "l": "dITP + H2O => dIMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28853", "l": "melibiose(out) + Na(+)(out) => melibiose(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9018747", "l": "RHOQ GEFs activate RHOQ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8857686", "l": "FITM1, FITM2 bind TAGs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39048", "l": "26-oxohexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] => 2 H(+) + H2O + hexacosanedioate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60658", "l": "1-hexadecanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9023619", "l": "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49447", "l": "(2-aminobenzoyl)acetyl-CoA + H2O <=> (2-aminobenzoyl)acetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31483", "l": "soyasapogenol E + UDP-alpha-D-glucuronate = H(+) + soyasapogenol E 3-O-beta-D-glucuronate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60782", "l": "CO2 + gibberellin A24 + H2O + succinate => 2-oxoglutarate + gibberellin A15 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390663", "l": "ADRA2A,B,C bind ADR,NAd (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66706", "l": "CoA + H(+) + mycophenolate => H2O + mycophenolyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391937", "l": "UDP/CysLT receptor can bind cysteinyl leukotrienes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854905", "l": "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2468040", "l": "Cohesin binds PDS5 and WAPAL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047542", "l": "2-furoyl-CoA dehydrogenase activity", "d": ["Catalysis of the reaction: 2-furoyl-CoA + A + H2O = 5-hydroxy-2-furoyl-CoA + AH(2) + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8981926", "l": "RAC1 and CDC42 activate PAK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1483004", "l": "Cho is phosphorylated to PCho by CHK dimer (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9697747", "l": "Caspase-8 and FLIP(L) processing at TNFR signaling complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24038", "l": "a ribonucleoside 5'-diphosphate + ADP => a ribonucleoside 5'-phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15237", "l": "2 Fe(III)-[cytochrome c2] + NADPH = 2 Fe(II)-[cytochrome c2] + H(+) + NADP(+)", "d": [], "t": []}, {"i": "EC:1.6.2.5", "l": "\"NADPH--cytochrome-c2 reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9754129", "l": "CDK6 inhibitors bind CDK6 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47760", "l": "a uridine in 21S rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in 21S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805122", "l": "AURKB binds TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.47", "l": "\"HIV-2 retropepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483203", "l": "PA is dephosphorylated to DAG by LPIN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950782", "l": "p-STAT1 binds p-STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66044", "l": "2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + H2O + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72699", "l": "acrylate + H(+) + NADH = NAD(+) + propanoate", "d": [], "t": []}, {"i": "EC:1.3.1.125", "l": "\"acrylate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59745", "l": "(9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] => CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25598", "l": "5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449058", "l": "Interleukin-1 family are secreted (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8944261", "l": "Association of procollagen type XIII (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68558", "l": "H(+) + NADH + UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose => NAD(+) + UDP-N-acetyl-alpha-D-quinovosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9638078", "l": "HEXB cleaves the terminal GalNAc from keratan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2671885", "l": "ASIC trimers:H+ transport extracellular Na+ to cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668545", "l": "NIK autophosphorylates on T559 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56673", "l": "dihydro-4-coumaroyl-CoA + NADP(+) => (E)-4-coumaroyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036042", "l": "long-chain fatty acyl-CoA binding", "d": ["Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42599", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 <=> prostaglandin G2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43642", "l": "3-oxotetradecanoyl-[ACP] + CO2 + CoA => dodecanoyl-CoA + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12421", "l": "ATP + D-tagatofuranose 6-phosphate => ADP + D-tagatofuranose 1,6-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21296", "l": "D-galactose + NAD(+) = D-galactono-1,4-lactone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.48", "l": "\"D-galactose 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1676145", "l": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43866", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out) => 1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250370", "l": "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8876472", "l": "NPC2 binds CHOL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45554", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-tetradecanoylethanolamine => H2O + N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.3.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35879", "l": "(9Z)-octadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000822", "l": "inositol hexakisphosphate binding", "d": ["Binding to inositol hexakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9793451", "l": "MLKL binds ITCH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203973", "l": "Vesicle budding (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5690808", "l": "UCHL3, SENP8 cleave NEDD8 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43816", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.205", "l": "\"galactogen 6beta-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19502", "l": "4-guanidinobutanoate + H2O => 4-aminobutanoate + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-76056", "l": "Recruitment of  RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-205039", "l": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37900", "l": "2-oxoglutarate + 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + O2 => 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77888", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)glycine + O2 => (1-deoxy-D-fructos-1-yl)amine + glyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73377", "l": "biotin(in) + 2 Na(+)(in) => biotin(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65410", "l": "NAD(+)(out) => NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941613", "l": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12084", "l": "D-mannitol + NAD(+) = D-fructose + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.67", "l": "\"mannitol 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69416", "l": "H(+) + H2O2 + thiocyanate = H2O + hypothiocyanous acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6795290", "l": "TORC2 complex phosphorylates SGK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-159819", "l": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15738", "l": "cyclopentanone + H(+) + NADPH + O2 => 5-valerolactone + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5220959", "l": "TDG excises 5-formylcytosine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2545196", "l": "FN1 dimerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615910", "l": "SUMOylation of PCNA with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68531", "l": "(2E,6E)-farnesyl diphosphate <=> beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190698", "l": "Transport of connexins to the ER-Golgi intermediate compartment (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20726", "l": "a (3E)-enoyl-CoA + H2O => a 4-saturated-(3S)-3-hydroxyacyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050047", "l": "L-leucine 2,3-aminomutase activity", "d": ["Catalysis of the reaction: L-leucine = (3R)-beta-leucine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111524", "l": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.41", "l": "\"xylogalacturonan beta-1,3-xylosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-500708", "l": "GRIK3 homomer binds glutamate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39962", "l": "1-hexadecanoylglycerol + H2O <=> glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0008512", "l": "sulfate:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in)."], "t": []}, {"i": "RHEA:28574", "l": "H(+)(in) + sulfate(in) = H(+)(out) + sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-500708", "l": "GRIK3 homomer binds glutamate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8982017", "l": "Active G alpha (q) binds RGS proteins (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1524186", "l": "Phosphorylation of PLCgamma by PDGFR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25247", "l": "(R)-lactate + glutathione + H(+) => (R)-S-lactoylglutathione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72647", "l": "1,6-dihydroxyphenazine + NADPH + O2 = 1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76251", "l": "glutarate(in) = glutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635839", "l": "ULK3:SUFU dissociates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102699", "l": "2-methylpropionitrile hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 2-methylpropionitrile + O2 + NADPH = 2-hydroxy-2-methylpropanenitrile + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2187358", "l": "PMEPA1 sequesters unphosphorylated SMAD2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75666", "l": "12-hydroperoxy-(10E,14Z)-eicosadienoate <=> 10,11-epoxy-12-hydroxy-(14Z)-eicosenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874137", "l": "ATF6B (ATF6-beta) translocates from the cytosol to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1254376", "l": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102477", "l": "2,5,7-trihydroxyflavanone 6C-glucoside dehydratase activity", "d": ["Catalysis of the reaction: 6C-glucosyl-2,5,7-trihydroxyflavanone = H+ + 6C-hexosyl chrysin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10812", "l": "H2O + N-succinyl-L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + N-succinyl-L-glutamate + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.71", "l": "\"succinylglutamate-semialdehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29922", "l": "alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ATP <=> ADP + alpha-D-Glc-(1->3)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14667", "l": "NH4(+) + xanthine => guanine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22626", "l": "acetaldehyde + pyruvate => (S)-4-hydroxy-2-oxopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65408", "l": "NAD(+)(in) = NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27778", "l": "4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) = 2-all-trans-octaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2130393", "l": "Transport of MHC II:Ii complex along Golgi to TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51795", "l": "H(+) + NADH + O2 + salicylate <=> 2,3-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66660", "l": "ATP + beta-D-glucosylceramide(in) + H2O = ADP + beta-D-glucosylceramide(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61336", "l": "ATP + H2O + protoporphyrin IX(in) = ADP + H(+) + phosphate + protoporphyrin IX(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8869603", "l": "SLC22A13 transports NCA from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1222491", "l": "Lactoferrin scavenges iron ions (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9700171", "l": "Active ALK phosphorylates PLCG1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12378", "l": "ADP + H(+) + L-fuculose 1-phosphate => ATP + L-fuculose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854736", "l": "FLT3LG dimer:FLT3 binds FLT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177926", "l": "Dephosphorylation of PAG by SHP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74671", "l": "UDP-beta-L-arabinopyranose(in) + UMP(out) = UDP-beta-L-arabinopyranose(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389986", "l": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604360", "l": "Initial activation of proMMP2 by MMP14 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.6.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24508", "l": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin E2", "d": [], "t": []}, {"i": "EC:1.1.1.189", "l": "\"prostaglandin-E2 9-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607742", "l": "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9612085", "l": "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-508292", "l": "SYK binds IL2RB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352108", "l": "SLC38A2 (ATA2)-mediated uptake of neutral amino acids (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57223", "l": "GTP + methylglyoxal <=> N(2)-(1-hydroxy-2-oxopropyl)-GTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66205", "l": "heptanoyl-CoA + O2 => (2E)-heptenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008657", "l": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63654", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624953", "l": "ARL13B binds INPP5E (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15832", "l": "a 16alpha-hydroxysteroid <=> a 16beta-hydroxysteroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698041", "l": "p-STAT5 binds the CDKN1A gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-380073", "l": "Liganded Gi-activating GPCR acts as a GEF for Gi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034001", "l": "chondroitin-sulfate-ABC exolyase activity", "d": ["Catalysis of the exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44694", "l": "CoA + H(+) + N-acylhexadecasphinganine => a fatty acyl-CoA + hexadecasphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-446202", "l": "Addition of the first glucose to the N-glycan precursor by ALG6 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39452", "l": "(3R)-hydroxy-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA => (2E,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855915", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2454264", "l": "11cROL binds to RLBP1 to form RLBP1:11cROL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189465", "l": "FECH binds Fe2+ to PRIN9 to form heme (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797616", "l": "CCNK:CDK12 binds RNA Pol II at DNA repair genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28033", "l": "[thioredoxin]-disulfide + dGDP + H2O <=> [thioredoxin]-dithiol + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61397", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysyl-[protein] => ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70300", "l": "H2O + L-dehydroascorbate => 2,3-dioxo-L-gulonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43744", "l": "ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)", "d": [], "t": []}, {"i": "EC:6.3.4.19", "l": "\"tRNA(Ile)-lysidine synthetase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52544", "l": "D-erythronate + NAD(+) = 2-dehydro-D-erythronate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.410", "l": "\"D-erythronate 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55023", "l": "5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O <=> 5,6-diaminouracil + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79130", "l": "L-phenylalanine + taurocholate <=> L-phenylalanocholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5659764", "l": "Defective SLC6A2 does not cotransport NAd, Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614544", "l": "Sulfite is oxidized to sulfate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57495", "l": "H2O + oxaloacetate + propanoyl-CoA <=> 2-methylcitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1632857", "l": "ULK1 phosphorylates AMBRA1:BECN1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614524", "l": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43517", "l": "2-carboxy-5-formylfuran + H2O => 2-carboxy-5-(dihydroxymethyl)furan", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5665871", "l": "ADRM1 binds 26S proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-169905", "l": "ARMS is phosphorylated by active TrkA receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786058", "l": "JAK1 binds IL4R in IL4-bound IL4R1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0017002", "l": "activin receptor activity", "d": ["Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202443", "l": "Oligomerization of CARMA1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2076419", "l": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015503", "l": "glutathione-regulated potassium exporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14891", "l": "(5Z,7E,9E,14Z,17Z)-icosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35568", "l": "H2O + N-(9Z,12Z-octadecadienoyl)-ethanolamine => (9Z,12Z)-octadecadienoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19639", "l": "2-oxoglutarate + H(+) + L-arginine + NADPH => D-nopaline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9838004", "l": "LONP1 degrades mitochondrial inner membrane proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21047", "l": "24-methylidenelophenol + S-adenosyl-L-methionine <=> (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11605", "l": "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + n acetyl-CoA => [O(7),N-diacetyl-alpha-D-neuraminosyl-(2->8)](n) + n CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51753", "l": "a 2-acylphloroglucinol + dimethylallyl diphosphate => a 2-acyl-4-prenylphloroglucinol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102898", "l": "levopimaradienol hydroxylase activity", "d": ["Catalysis of the reaction: H+ + levopimaradienol + NADPH + O2 = levopiramadiene-diol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0044374", "l": "sequence-specific DNA binding, bending", "d": ["The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687097", "l": "p-S857 NCOA3 binds ETV4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41266", "l": "NAD(+) + prostaglandin A1 <=> 15-oxo-prostaglandin A1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045518", "l": "interleukin-22 receptor binding", "d": ["Binding to an interleukin-22 receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10565", "l": "H2O + oxaloacetate 4-methyl ester => H(+) + methanol + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8857555", "l": "EGFR phosphorylates GPNMB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34720", "l": "15-methylhexadecasphing-4-enine 1-phosphate => (2E)-13-methyltetradecenal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69495", "l": "O2 + octan-1-ol <=> H2O2 + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41539", "l": "2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine <=> 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212642", "l": "L-Glutamine transport into neurons (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28053", "l": "H2O + NADP(+) <=> NAD(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9621179", "l": "Cinaciguat binds sGC:NO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32730", "l": "a very-long-chain acyl-CoA + H(+) + malonyl-CoA <=> a very-long-chain 3-oxoacyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788597", "l": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5675868", "l": "ULK1 phosphorylates ATG13 and RB1CC1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-913451", "l": "IL3RB is phosphorylated on Ser-585 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44793", "l": "2-demethylmenaquinol-12 + S-adenosyl-L-methionine => H(+) + menaquinol-12 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.58", "l": "\"lipopolysaccharide glucosyltransferase I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682385", "l": "The phagophore extends from the PIP3-enriched structure (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37840", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA => 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59749", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] => CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72322", "l": "n chloride(in) + urate(out) <=> n chloride(out) + urate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0044653", "l": "dextrin alpha-glucosidase activity", "d": ["Catalysis of the reaction: dextrin + H2O = alpha-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71574", "l": "5-O-(L-seryl)-dTMP in DNA + H(+) <=> 5-aminoethoxy-methyl-dUMP in DNA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42007", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) <=> 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182594", "l": "Association of INK4 family proteins with CDK4/6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57140", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1614614", "l": "Cysteine is degraded to serine and H2S (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794347", "l": "Homer1,2,3 dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-442317", "l": "ZIP6 and ZIP14 mediate zinc influx into cells (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785165", "l": "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37774", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA <=> 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.67", "l": "\"endopeptidase So\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.16", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66895", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 10-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71326", "l": "chloride(out) + L-asparagine(out) + 2 Na(+)(out) <=> chloride(in) + L-asparagine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.24.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37193", "l": "adenosine 2'-phosphate + H(+) => 2',3'-cyclophospho-AMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5676133", "l": "CD74 binds MIF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8937442", "l": "CES3 hydrolyses CHEST to CHOL and LCFA(-) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36466", "l": "glycyl-L-glutamate + H2O <=> glycine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54852", "l": "H(+) + heptan-4-one + NADPH + O2 = H2O + NADP(+) + propyl butanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103099", "l": "UDP-glucose:5-methylthiopentylhydroximate S-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + 5-methylthiopentylhydroximate = H+ + 4-methylthiobutyldesulfoglucosinolate + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983153", "l": "E1 mediated ubiquitin activation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956103", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0120502", "l": "fatty acid omega-1 hydroxylase activity", "d": ["Catalysis of the reaction: an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]."], "t": []}, {"i": "RHEA:44548", "l": "an (omega-1)-ethyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an (omega-1)-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654592", "l": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36748", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose => beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799581", "l": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12627", "l": "D-glucose + sinapoyl (S)-malate => (S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74584", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-glutamyl-[protein] => N-acetyl-L-cysteine + N-terminal L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2130282", "l": "Degradation of ubiquitinated beta catenin by the proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952823", "l": "p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60829", "l": "a 5'-end triphospho-adenosine in mRNA + H2O => a 5'-end diphospho-adenosine in mRNA + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72073", "l": "H(+) + N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide => L-histidyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875318", "l": "RAB3 GEFs exchange GTP for GDP on RAB3A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928576", "l": "RHOA:GTP binds ROCK, activating it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209566", "l": "TRAF6 is auto-ubiquitinated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-419644", "l": "Transphosphorylation of pLIMK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53469", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol => (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015592", "l": "methylgalactoside transmembrane transporter activity", "d": ["Enables the transfer of methylgalactoside from one side of a membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66337", "l": "L-glutamate(out) => L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9853369", "l": "PLK1 phosphorylates FIRMM at S744 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9009308", "l": "STUB1 polyubiquitinates RUNX2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166015", "l": "Association of LBP with LPS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391157", "l": "p-4Y-SIRPA:CD47 binds SKAP2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45310", "l": "11beta-prostaglandin F2-ethanolamide + NADP(+) => H(+) + NADPH + prostaglandin D2-ethanolamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070698", "l": "type I activin receptor binding", "d": ["Binding to a type I activin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021520", "l": "NOTCH3 binds WWP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168889", "l": "Haptoglobin-related Protein binds Hemoglobin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004756", "l": "selenide, water dikinase activity", "d": ["Catalysis of the reaction: ATP + H2O + hydrogen selenide = AMP + 3 H+ + phosphate + selenophosphorate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15423", "l": "a long-chain fatty acyl-CoA + AMP + diphosphate => a long-chain fatty acid + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9845587", "l": "ST8SIA5 transfers Neu5Ac to gangliosides (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72903", "l": "butyrolactone II + dimethylallyl diphosphate = butyrolactone I + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57659", "l": "a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GT1balpha + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35246", "l": "ADP + H(+) + thiamine diphosphate <=> adenosine thiamine triphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31587", "l": "FMNH2 + NADH + O2 + uracil = (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791235", "l": "GADD45A binds AURKA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-71732", "l": "PPA1 hydrolyzes pyrophosphate to orthophosphate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5339528", "l": "TUSC3 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21225", "l": "CDP-choline + sphing-4-enine => CMP + H(+) + sphing-4-enine-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8870628", "l": "Phosphorylated FOXO3 translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088299", "l": "FOXM1 stimulates CCNB2 transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69028", "l": "5beta-dihydrotestosterone + H(+) + NADPH = 5beta-androstane-3alpha,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-174054", "l": "Formation of Cyclin A:Cdk2 complexes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-418172", "l": "F2R binds ARRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55724", "l": "17-(4-hydroxyphenyl)heptadecanoyl-5'-AMP + holo-[(phenol)carboxyphthiodiolenone synthase] = 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2201341", "l": "Endocytosis of TRAM (TICAM2) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985950", "l": "p-Y694-STAT5A, p-STAT5B dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-73718", "l": "UBF-1 Binds rDNA Promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654705", "l": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55192", "l": "2-oxoglutarate + 3-methyldodecanoyl-CoA + O2 = 2-hydroxy-3-methyldodecanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-194308", "l": "VEGF-C,D bind to VEGFR3 leading to receptor dimerization (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70555", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446204", "l": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54266", "l": "(3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + CO2 + succinate => 2-oxoglutarate + L-histidyl-[ankyrin-repeat domain protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9611851", "l": "ADRB2 bind ADR,NAd (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34692", "l": "(R)-lactoyl-CoA => acryloyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202541", "l": "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56100", "l": "[small archaeal modifier protein]-C-terminal Gly-Gly + ATP + H(+) = [small archaeal modifier protein]-C-terminal Gly-Gly-AMP + diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.100", "l": "\"SAMP-activating enzyme\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75726", "l": "(9Z,12Z)-octadecadienoate + H2O <=> (10S)-hydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "58.535447505802594", "identifiers": [{"i": "GO:0016758", "l": "hexosyltransferase activity", "d": ["Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)."], "t": []}, {"i": "EC:2.4.1.-", "l": "\"Hexosyltransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004732", "l": "pyridoxal oxidase activity", "d": ["Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6785986", "l": "DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22798", "l": "ADP + D-hamamelose 2'-phosphate + H(+) => ATP + D-hamamelose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74733", "l": "Insulin receptor de-phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174057", "l": "Multiubiquitination of APC/C-associated Cdh1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211190", "l": "Caspase 3-mediated cleavage of DFF45 (117) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691154", "l": "HFE binds TFRC dimer (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619843", "l": "ERKs phosphorylate RSKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828024", "l": "SOX17 and TFAP2C bind the NANOG gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013161", "l": "CDC42 GAPs stimulate CDC42 GTPase activity (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70592", "l": "PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42246", "l": "3-oxopentanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-204364", "l": "ROBO1 binds SLIT2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336184", "l": "GPR37L binds prosaposin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71978", "l": "glutathione(out) + 3 Na(+)(out) <=> glutathione(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78711", "l": "3-O-beta-D-glucosyl-D-glucuronate + phosphate = aldehydo-D-glucuronate + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-76434", "l": "Dehalogenation of carbon tetrachloride to form a free radical (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52482", "l": "(3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.12.99.-", "l": "\"With other acceptors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706293", "l": "Active FLT3 binds to CBL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1602374", "l": "PS is hydrolyzed to 1-acyl LPS by PLA2[15] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16117", "l": "acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.16", "l": "\"acetoacetate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33452", "l": "A + H2O + N(6),N(6)-dimethyl-L-lysyl-[protein] => AH2 + formaldehyde + N(6)-methyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102033", "l": "long-chain fatty acid omega-hydroxylase activity", "d": ["Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2023455", "l": "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200651", "l": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158546", "l": "UGTs glucuronate APAP to APAP-GlcA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1168376", "l": "STIM1 oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676592", "l": "2xRANK binds RANKL,sRANKL trimer:RANK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26244", "l": "geranylgeranyl diphosphate <=> diphosphate + elisabethatriene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64850", "l": "(3Z)-hex-3-en-1-yl benzoate + CoA => (3Z)-hex-3-en-1-ol + benzoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9758674", "l": "CYP3A4 oxidizes PREDN,PREDL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60386", "l": "N-(2,3-dihydroxybenzoyl)-L-serine trimer => enterobactin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047873", "l": "dolichyl-phosphatase activity", "d": ["Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0017147", "l": "Wnt-protein binding", "d": ["Binding to a Wnt-protein, a secreted growth factor involved in signaling."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651971", "l": "Defective SLC34A3 does not cotransport Pi, 2Na+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44389", "l": "1-heptadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA => 1-heptadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810392", "l": "TMEM55B translocates to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59846", "l": "(R)-isodihydrodehydrodiconiferyl alcohol + NADP(+) => (+)-dehydrodiconiferyl alcohol + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2032770", "l": "Translocation of YAP1 to the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421174", "l": "inosine + orthophosphate <=> hypoxanthine + D-ribose 1-phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985460", "l": "RUNX2 binds RB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9825782", "l": "p-S207 KARS1 dimer binds MITF-M:HINT1 dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-76496", "l": "PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706364", "l": "Internalization of ubiquitinated FLT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66160", "l": "hexanoyl-CoA + tyramine = CoA + H(+) + N-hexanoyltyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10537", "l": "4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H2O => 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46714", "l": "H(+) + N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12965", "l": "ATP + D-galacturonate = 1-phospho-alpha-D-galacturonate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.44", "l": "\"galacturonokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5336453", "l": "NIPAs transport Mg2+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5618105", "l": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53694", "l": "H(+) + prostaglandin E2 + sn-glycerol 3-phosphocholine => 2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098601", "l": "selenomethionine adenosyltransferase activity", "d": ["Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15242", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taxa-4(20),11-dien-5alpha-yl acetate => 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14751", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+) => 1-hydroxy-2-naphthoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8938231", "l": "RUNX1:CBFB binds CREBBP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37368", "l": "CDP-2,3-bis-O-(phytanyl)-sn-glycerol + L-serine => 2,3-bis-O-phytanyl-sn-glycero-3-phospho-L-serine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50262", "l": "(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate => 11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.417", "l": "\"3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55988", "l": "H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein]", "d": [], "t": []}, {"i": "EC:3.2.1.106", "l": "\"mannosyl-oligosaccharide glucosidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21587", "l": "NAD(+) + propane-1,2-diol 1-phosphate <=> H(+) + hydroxyacetone phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8871226", "l": "RET binds GFRA1,GFRA2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797763", "l": "TP53 inhibits BIRC5 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871260", "l": "YAP1 binds TEAD2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8936849", "l": "AHR:2xHSP90:AIP:PTGES3 binds TCDD (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200729", "l": "SLC46A1 transports FOLA from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694446", "l": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30628", "l": "(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) => (2S)-2-acetolactate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45367", "l": "H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine <=> (11Z)-eicosenoate + (4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373075", "l": "Metabotropic glutamate receptors bind glutamate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008428", "l": "ribonuclease inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of ribonuclease."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835944", "l": "ADAR1 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18178", "l": "a 2,3-saturated acyl-CoA + NAD(+) => a (2E)-enoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-432067", "l": "Aquaporin-4 passively transports water out of cell (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10758", "l": "AMP + diphosphate + H(+) + phosphoenolpyruvate => ATP + phosphate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50737", "l": "a quinone + 2 H(+) + hydrogen sulfide + sulfite => a quinol + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112381", "l": "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28159", "l": "alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate => alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928646", "l": "EPHAs bind EFNAs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26249", "l": "H(+) + levopimaradienol + NADPH + O2 = 2 H2O + levopimaradienal + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9012374", "l": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209573", "l": "p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6799695", "l": "GPX5,6 reduce H2O2 to H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1905761", "l": "SCF ubiquitin ligase complex binding", "d": ["Binding to a SCF ubiquitin ligase complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-975608", "l": "LRAT esterifies RBP2:atROL and FACYLs to atREs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8850356", "l": "TCR binds microbial lipid-based antigen via CD1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34896", "l": "ATP + H2O + selenite(out) => ADP + H(+) + phosphate + selenite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18522", "l": "licodione + S-adenosyl-L-methionine => 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2408543", "l": "SeCysta is hydrolysed to Sec by PXLP-K212-CTH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1022127", "l": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8949178", "l": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68084", "l": "GTP + L-histidyl-[RNA ligase] = diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9654774", "l": "Transcription of PPP1R15A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.-", "l": "\"Nucleotidyltransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61991", "l": "cytidine(72) in tRNA + S-adenosyl-L-methionine <=> 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28273", "l": "acetyl-CoA + spermidine <=> CoA + H(+) + N(8)-acetylspermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-211224", "l": "Association of DFF40 with DFF45 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-975311", "l": "HTR3 pentamers:5HT transport Na+,K+,Ca2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26188", "l": "1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.250", "l": "\"D-inositol-3-phosphate glycosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16116", "l": "2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP(+) <=> 2 apo-[cyanocobalamin reductase] + 2 cyanocob(III)alamin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218820", "l": "Src kinases phosphorylate VAV (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8856808", "l": "Recruitment of AP-2 complex and clathrin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35776", "l": "L-glutamine + UDP-3-oxo-alpha-D-glucose => 2-oxoglutaramate + UDP-alpha-D-kanosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0008821", "l": "crossover junction DNA endonuclease activity", "d": ["Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68458", "l": "(2E)-glutaconyl-CoA + H2O => (S)-3-hydroxyglutaryl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-266315", "l": "LCAT + spherical HDL <=> LCAT:spherical HDL complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74372", "l": "a carboxylate(out) + nicotinate(in) => a carboxylate(in) + nicotinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032142", "l": "single guanine insertion binding", "d": ["Binding to a double-stranded DNA region containing a single guanine insertion or a deletion that results in an unpaired guanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75320", "l": "chloride(out) + D-alanine(out) + 2 Na(+)(out) => chloride(in) + D-alanine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140777", "l": "protein-containing complex stabilizing activity", "d": ["A molecular function that involves direct binding to one of the subunits of a protein-containing complex, thus preventing an interaction with a factor that would promote dissociation of the complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9659611", "l": "ANO1 inhibitors bind ANO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25283", "l": "O2 + reduced [NADPH--hemoprotein reductase] + squalene => (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.135", "l": "\"galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2730849", "l": "Calcineurin binds and dephosphorylates NFAT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56413", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70634", "l": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2396079", "l": "VTN binds Plasminogen activator inhibitor- 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1433451", "l": "JAK2 binds to p-KIT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67584", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5687121", "l": "p-S MAPKAPK5 phosphorylates HSPB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50503", "l": "acetyl-CoA + N-terminal L-alanyl-[protein] <=> CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9659611", "l": "ANO1 inhibitors bind ANO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-375417", "l": "SLC36A1-mediated uptake of glycine, proline, and alanine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-352029", "l": "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20375", "l": "AMP + diphosphate + propanoyl-CoA => ATP + CoA + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399936", "l": "Inhibition of integrin activation by sequestering PIP5KIgamma (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31213", "l": "diphosphate + L-adenosylselenomethionine + phosphate => ATP + H2O + L-selenomethionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-444476", "l": "FPRL2 receptor binds a wide range of ligands (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29599", "l": "monacolin L carboxylate + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + monacolin J carboxylate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.125", "l": "\"monacolin L hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44712", "l": "a 1,2-diacylglycerol + H2O = a 1-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005307", "l": "choline:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)."], "t": []}, {"i": "RHEA:76443", "l": "choline(out) + n Na(+)(out) = choline(in) + n Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8848580", "l": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-373700", "l": "Caspase-9 binds DCC:DIP13alpha complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001517", "l": "N-acetylglucosamine 6-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8863727", "l": "STON2 is neddylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8854588", "l": "TBC1D25 (OATL1) binds ATG8 homologues (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9624876", "l": "RAN:GTP recruits nuclear envelope (NE) membranes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45551", "l": "phycourobilin-L-cysteinyl(84)-[R-phycocyanin alpha-subunit] <=> (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[R-phycocyanin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429567", "l": "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5624239", "l": "Defective SLC17A5 does not cotransport Neu5Ac, H+ from lysosomal lumen to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114688", "l": "PLC-beta hydrolyses PIP2 to DAG and IP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77895", "l": "H2O + N(6)-(1-deoxy-beta-D-fructopyranos-1-yl)-L-lysine + O2 = (1-deoxy-D-fructos-1-yl)amine + (S)-2-amino-6-oxohexanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-110356", "l": "Displacement of MPG glycosylase by APEX1 at the AP site (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-170846", "l": "TGFBR2 recruits TGFBR1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-400509", "l": "Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035978", "l": "Defective HEXA does not cleave the terminal GalNAc from keratan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3247847", "l": "WLS is endocytosed to the early endosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938930", "l": "RUNX1 binds ELF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66340", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3769392", "l": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61883", "l": "1-O-methyl-20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 <=> 1-O-methyl-12-hydroperoxy-20-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73339", "l": "ATP + beta-alanine + H(+) = beta-alanyl-5'-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482920", "l": "PG is hydrolyzed to 2-acyl LPG by PLA2[14] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63456", "l": "(2E,6E,10E)-geranylgeraniol + CTP = (2E,6E,10E)-geranylgeranyl phosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70581", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41604", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41846", "l": "(2E)-octenoyl-[ACP] + H2O => (3R)-hydroxyoctanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44012", "l": "(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) = (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64621", "l": "(E)-sinapyl alcohol + acetyl-CoA => (E)-sinapoyl actetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5336466", "l": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625797", "l": "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-916855", "l": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77633", "l": "1-tetradecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA => (9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193452", "l": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-446391", "l": "Formation of the PINCH-ILK-parvin complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52649", "l": "H2O + L-arabino-1,4-lactone 5-phosphate => 5-phospho-L-arabinonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9762345", "l": "PREDN:ALB dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44408", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 2-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.299", "l": "\"malate dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168839", "l": "SHP1 (PTPN6) binds JAK2 in the receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73974", "l": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66028", "l": "AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine = (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.379", "l": "\"[methyl coenzyme M reductase]-L-arginine C-5-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16093", "l": "(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24R)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66531", "l": "ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] <=> diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17729", "l": "an acyl-CoA + cholesterol = a cholesterol ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50995", "l": "thromboxane B2(out) <=> thromboxane B2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-430190", "l": "p-SLP-76 binds NCK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008838", "l": "diaminopropionate ammonia-lyase activity", "d": ["Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-68914", "l": "DNA polymerase alpha:primase binds at the origin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4093329", "l": "EFNBs bind SDCBP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211966", "l": "CYP2D6 4-hydroxylates debrisoquine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1675810", "l": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-419001", "l": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5096532", "l": "Defective GALNT12 does not transfer GalNAc to mucins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39896", "l": "7-deoxyloganetate + UDP-alpha-D-glucose => 7-deoxyloganate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40335", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102818", "l": "lycopene cleavage oxygenase activity", "d": ["Catalysis of the reaction: lycopene + 2 O2 = 2 sulcatone + bixin aldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047853", "l": "difructose-anhydride synthase activity", "d": ["Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052684", "l": "L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity", "d": ["Catalysis of the reaction: indole + L-serine = L-tryptophan + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389487", "l": "Orexin 2 receptor can bind orexin-B neuropeptide (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22429", "l": "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 => 2 H2O + isopenicillin N", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37809", "l": "1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA => 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5357429", "l": "AXL autophosphorylates on Y779 and Y821 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9693198", "l": "RHOD binds effectors at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111970", "l": "PKC phosphorylates GRK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2465924", "l": "OPN1LW binds 11cRAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44836", "l": "a globoside NORint (d18:1(4E)) + UDP-alpha-D-galactose = a globoside NOR2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76793", "l": "9-hydroxyhexadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => hexadecanoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964284", "l": "BTK in active Gq-BTK complex is activated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10170", "l": "biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin] => 15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170868", "l": "Activated type I receptor phosphorylates SMAD2/3 directly (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76069", "l": "an (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-homocysteine => an (S)-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23570", "l": "(3Z)-decenoyl-[ACP] => (2E)-decenoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-177937", "l": "Phosphorylation of EGFR by SRC kinase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62425", "l": "(E)-caffeoyl-CoA + H2O => 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205238", "l": "SHP2 interacts with p-KIT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44069", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + H2O => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12576", "l": "(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-glucose = (5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.66", "l": "\"procollagen glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51054", "l": "5alpha-androst-1-ene-3,17-dione + AH2 => 5alpha-androstan-3,17-dione + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690159", "l": "USP21 deubiquitinates RIPK1,DDX58 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33067", "l": "(4R)-hydroxysphinganine 1-phosphate + H2O = (4R)-hydroxysphinganine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681382", "l": "KIT mutants bind ripretinib (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40689", "l": "1-O-tetradecylglycerone 3-phosphate + H(+) + hexadecanoate => 1-hexadecanoylglycerone 3-phosphate + tetradecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26343", "l": "H(+) + L-methionine + Se-methyl-L-selenocysteine => L-selenocysteine + S-methyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-909721", "l": "Translocation of ISGF3 complex to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64686", "l": "3-O-(alpha-D-glucosyl)-L-threonyl-[protein] + H(+) + UDP => L-threonyl-[protein] + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50400", "l": "L-cysteinyl-[PqsC protein] + octanoyl-CoA = CoA + S-octanoyl-L-cysteinyl-[PqsC protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445757", "l": "IL1 receptor antagonist protein binds Interleukin 1 receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30843", "l": "H2O + N-formylmaleamate = formate + H(+) + maleamate", "d": [], "t": []}, {"i": "EC:3.5.1.106", "l": "\"N-formylmaleamate deformylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68118", "l": "a triacylglycerol + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol => a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12593", "l": "a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.8.5", "l": "\"CDP-diacylglycerol--glycerol-3-phosphate 1-phosphatidyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51220", "l": "1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5666160", "l": "AURKB phosphorylates DIAPH2-2 at kinetochores (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43154", "l": "H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine => adenosine(58) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-965019", "l": "2xPNPO:2xFMN oxidizes PDXP to PXLP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5638016", "l": "RP2:ARL3:GDP:UNC119B dissociates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72046", "l": "L-glutamate(in) + orotate(out) <=> L-glutamate(out) + orotate(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43231", "l": "L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine <=> H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008012", "l": "structural constituent of adult chitin-based cuticle", "d": ["The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332363", "l": "Autophosphorylation and activation of CAMK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71283", "l": "chloride(out) + L-glutamine(out) + 2 Na(+)(out) = chloride(in) + L-glutamine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1247910", "l": "CNDP2:2Mn2+ dimer hydrolyses CysGly (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61112", "l": "(2R,3R)-dihydrokaempferol + O2 + reduced [NADPH--hemoprotein reductase] = (2R,3R)-dihydroquercetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5362564", "l": "ADH1A,1C,4 oxidise atROL to atRAL in vitro (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6799191", "l": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46934", "l": "5-epi-valiolone 7-phosphate => 2-epi-5-epi-valiolone 7-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4090288", "l": "PIAS1,3 SUMOylate MBD1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8981570", "l": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390224", "l": "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46848", "l": "4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NADP(+) = 5alpha-cholest-8-en-3-one + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-198266", "l": "PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-500708", "l": "GRIK3 homomer binds glutamate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687112", "l": "MAPK6 is degraded by the 26S proteasome (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13193", "l": "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate", "d": [], "t": []}, {"i": "EC:5.4.99.18", "l": "\"5-(carboxyamino)imidazole ribonucleotide mutase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50144", "l": "ethyl (9Z)-hexadecenoate + H2O = (9Z)-hexadecenoate + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4090284", "l": "SUMOylation of HIPK2 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60632", "l": "all-trans-4-oxoretinol + NAD(+) = all-trans-4-oxoretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5682607", "l": "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-70723", "l": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35125", "l": "H(+)(in) + L-alanyl-D-glutamate(in) => H(+)(out) + L-alanyl-D-glutamate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.60", "l": "\"N-acylmannosamine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14116", "l": "a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O <=> a 3'-end 2'-deoxyribonucleotide-DNA + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686430", "l": "MUS81 binds EME1, EME2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71764", "l": "2-oxoglutarate(out) + citrate(in) => 2-oxoglutarate(in) + citrate(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14429", "l": "a [oligopeptide](in) + ATP + H2O = a [oligopeptide](out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77967", "l": "all-trans-hexaprenyl diphosphate = diphosphate + macrophomene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42754", "l": "H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine => pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641342", "l": "SUMOylation of TOP2A with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005456", "l": "CMP-N-acetylneuraminate transmembrane transporter activity", "d": ["Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2213201", "l": "Formation of collagen fibres (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9624845", "l": "RCC1 stimulates GDP to GTP exchange on RAN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27919", "l": "H2O + NADP(+) + propanal => 2 H(+) + NADPH + propanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989770", "l": "Expression of PLIN2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45212", "l": "acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+) = CO + CoA + methyl-Co(III)-[corrinoid Fe-S protein]", "d": [], "t": []}, {"i": "EC:2.3.1.169", "l": "\"CO-methylating acetyl-CoA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77274", "l": "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59398", "l": "D-leucine => L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76216", "l": "2'-deoxyguanosine(in) => 2'-deoxyguanosine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49240", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-D-glucosamine(out) = L-histidyl-[protein] + N-acetyl-D-glucosamine 6-phosphate(in)", "d": [], "t": []}, {"i": "EC:2.7.1.193", "l": "\"protein-N(pi)-phosphohistidine--N-acetyl-D-glucosamine phosphotransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1253325", "l": "ERBB4s80 binds TAB2:NCOR1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8854044", "l": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610726", "l": "The IFT-A complex recruits TULP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68166", "l": "H(+) + 2 H2O + N-(8'-oxogeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] => N-(8'-hydroxygeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250972", "l": "botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.99.11", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1306979", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28903", "l": "D-alanine(in) + H(+)(in) = D-alanine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24785", "l": "3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050032", "l": "L-rhamnonate dehydratase activity", "d": ["Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40304", "l": "A + dodecanedioyl-CoA => (2E)-dodecenedioyl-CoA + AH2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40086", "l": "hexacosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> 26-hydroxyhexacosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65245", "l": "(2S)-hesperetin + UDP-alpha-D-glucose => (2S)-hesperetin 7-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8954327", "l": "UCKL1 phosphorylates urindine, cytidine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11049", "l": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid => 1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5655466", "l": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9794475", "l": "Cipro:ALB dissociates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.88", "l": "\"repressor LexA\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-196126", "l": "CHOL translocates from cytosol to mitochondrial intermembrane space (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46166", "l": "a quinol + NADP(+) => a quinone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58913", "l": "ATP + H2O + iron(III) dicitrate(out) => ADP + H(+) + iron(III) dicitrate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0032090", "l": "Pyrin domain binding", "d": ["Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-111285", "l": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198621", "l": "AKT phosphorylates caspase-9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76829", "l": "butanal + H(+) + NADH + NH4(+) => butylamine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12645", "l": "CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.2.7.8", "l": "\"indolepyruvate ferredoxin oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25720", "l": "H(+) + N,N-dihydroxy-L-trihomomethionine => (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29348", "l": "2 H(+)(in) + orotate(in) => 2 H(+)(out) + orotate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3364026", "l": "SET1 complex trimethylates H3K4 at the MYC gene (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2395364", "l": "LTBP4 binds TGF-Beta-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-419351", "l": "PAF receptor binds platelet activating factor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74241", "l": "ADA catalyzes the deamination of (deoxy)adenosine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482850", "l": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74948", "l": "PP2A dephosphorylates p-RHO to RHO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44081", "l": "ATP + CoA + undecanoate => AMP + diphosphate + undecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19505", "l": "indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.34", "l": "\"indolylacetylinositol arabinosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5607744", "l": "MALT1 binds BCL10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76292", "l": "Na(+)(out) + xanthine(out) => Na(+)(in) + xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2993780", "l": "Transfer of SUMO1 from E1 to UBE2I (UBC9) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-162730", "l": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654165", "l": "p-4Y-PLCG1 dissociates from activated FGFR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76475", "l": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33983", "l": "(+)-copalyl diphosphate = diphosphate + miltiradiene", "d": [], "t": []}, {"i": "EC:4.2.3.131", "l": "\"miltiradiene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66071", "l": "4-methyl-2-oxopentanoate + L-kynurenine <=> H2O + kynurenate + L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38972", "l": "O2 + octadecanoyl-CoA => (2E)-octadecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76006", "l": "glutarate(in) + xanthurenate(out) <=> glutarate(out) + xanthurenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21663", "l": "benzaldehyde + H2O + NADP(+) <=> benzoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2396370", "l": "VTN binds collagens II, III and V (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63847", "l": "[thioredoxin]-dithiol + cumene hydroperoxide <=> 2-phenylpropan-2-ol + [thioredoxin]-disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30186", "l": "L-galactonate + NAD(+) <=> H(+) + keto-D-tagaturonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-191380", "l": "Mevalonate is phosphorylated to mevalonate-5-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59902", "l": "CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate => 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654614", "l": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828200", "l": "TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55196", "l": "2-hydroxyoctadecanoyl-CoA = formyl-CoA + heptadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039556", "l": "MDA-5 binding", "d": ["Binding to MDA-5, a cytoplasmic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74481", "l": "(Z)-dehydrocyclopeptine + CO2 + H2O + succinate => (-)-cyclopeptine + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37185", "l": "1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (9Z)-octadecenoyl-CoA + 1-eicosanoyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74940", "l": "2-oxoglutarate + a (3R)-3-[(carboxymethyl)amino]fatty acid + O2 => a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-69116", "l": "Formation of Okazaki fragments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-418925", "l": "ADORA2A,B bind Ade-Rib (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-165179", "l": "Formation of TSC1:TSC2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35725", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + CoA => hexadecanoyl-CoA + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161814", "l": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606839", "l": "ARSC hydrolyzes steroid sulfates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111881", "l": "Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44500", "l": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "67.604068309348747", "identifiers": [{"i": "GO:0140375", "l": "immune receptor activity", "d": ["Receiving a signal and transmitting it in a cell to initiate an immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2106579", "l": "WWTR1:SMAD translocates to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77314", "l": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-196402", "l": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77589", "l": "Recognition of AAUAAA sequence by CPSF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38391", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69079", "l": "(R)-noradrenaline + H2O + O2 <=> (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44129", "l": "(9E)-octadecenoyl-CoA + hexadecan-1-ol => CoA + hexadecanyl (9E)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62644", "l": "(5Z,8Z)-eicosadienoate + O2 = (5S)-hydroperoxy-(6E,8Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65427", "l": "AMP(in) + NAD(+)(out) <=> AMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73108", "l": "acacetin + S-adenosyl-L-methionine => apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047848", "l": "dephospho-[reductase kinase] kinase activity", "d": ["Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1676105", "l": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4411372", "l": "TCF/LEF:CTNNB1 promote transcription of AXIN2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-912685", "l": "UBP43 binds IFNAR2 and prevents JAK1 interaction (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0097001", "l": "ceramide binding", "d": ["Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5637806", "l": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028673", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688456", "l": "MLKL binds FLOT1, FLOT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61864", "l": "AH2 + dehydroprobetaenone I = A + probetaenone I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0160011", "l": "NAD-dependent protein decrotonylase activity", "d": ["Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide."], "t": []}, {"i": "RHEA:69332", "l": "H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] + NAD(+) = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008883", "l": "glutamyl-tRNA reductase activity", "d": ["Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807875", "l": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690873", "l": "ACO1 binds 4Fe-4S (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9841189", "l": "GLA hydrolyzes PSAP(195-273):Gal2Cer:PE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52439", "l": "a 2,6-O-bis(alpha-D-mannopyranosyl)-1-phosphatidyl-1D-myo-inositol + an acyl-CoA <=> 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9855252", "l": "SDHA:SDHB binds to SDHC:SDHD (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42735", "l": "guanosine(527) in 16S rRNA + S-adenosyl-L-methionine <=> N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33523", "l": "ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O = acetate + ergosta-5,7,22,24(28)-tetraen-3beta-ol + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15288", "l": "AMP + dimethylallyl diphosphate <=> diphosphate + N(6)-(dimethylallyl)adenosine 5'-phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33671", "l": "an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O = 2 Fe(II)-[cytochrome b5] + 2 H(+) + N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8878654", "l": "ACP6 hydrolyses MYS-LPA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020270", "l": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46193", "l": "3beta-hydroxyandrost-5-en-17-one + O2 + reduced [NADPH--hemoprotein reductase] => 3beta,7alpha-dihydroxyandrost-5-en-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190782", "l": "Budding of connexon-containing transport vesicles from the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12138", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30757", "l": "ADP + carbamoyl phosphate => ATP + carbamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9619024", "l": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450333", "l": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19523", "l": "acetyl phosphate + CoA => acetyl-CoA + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46084", "l": "H2O + sn-glycerol 1-phosphate = glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51286", "l": "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate => (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50763", "l": "a quinone + H2O + sulfite <=> a quinol + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70893", "l": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352872", "l": "fructose 6-phosphate <=> glucose 6-phosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177922", "l": "EGFR dimerization (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73501", "l": "4',7-dihydroxy-3'-methoxyflavone + H(+) + S-adenosyl-L-homocysteine => 3',4',7-trihydroxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25197", "l": "5-amino-6-(5-phospho-D-ribitylamino)uracil + H2O = 5-amino-6-(D-ribitylamino)uracil + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.104", "l": "\"5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187916", "l": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2424243", "l": "SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17428", "l": "CoA + NADP(+) + pyruvate <=> acetyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11621", "l": "H2O + L-2-amino-4-chloropent-4-enoate => 2-oxopent-4-enoate + chloride + H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52866", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+) => an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69827", "l": "(22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase] = (22R,23R)-22,23-dihydroxycampesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1676203", "l": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445448", "l": "HHIP binds Hedgehog (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46017", "l": "(20R)-20-hydroxypregn-4-en-3-one + NAD(+) => H(+) + NADH + progesterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0038021", "l": "leptin receptor activity", "d": ["Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69475", "l": "a (3R)-hydroxyacyl-[ACP] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose <=> a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55898", "l": "5-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9686710", "l": "Cleavage of S protein into S1:S2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33399", "l": "N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out) = L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in)", "d": [], "t": []}, {"i": "EC:2.7.1.192", "l": "\"protein-N(pi)-phosphohistidine--N-acetylmuramate phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73787", "l": "dimethylallyl diphosphate + tardioxopiperazine A = diphosphate + variecolorin L", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848124", "l": "PTK6 phosphorylates STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20465", "l": "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34580", "l": "2 2-oxoglutarate + 2 O2 + pentalenolactone D => 2 CO2 + H2O + pentalenolactone F + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9709406", "l": "CO binds to Cytochrome c oxidase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32145", "l": "L-arginine(out) => L-arginine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16884", "l": "hydrogen cyanide + thiosulfate <=> 2 H(+) + sulfite + thiocyanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71941", "l": "2-oxoglutarate(in) + 3 Na(+)(in) => 2-oxoglutarate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928607", "l": "p-EPHs bind VAV2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12501", "l": "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) => 3,4-dehydrothiomorpholine-3-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33173", "l": "D-maltose(out) => D-maltose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8964619", "l": "PAK1 binds ARHGEF6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71261", "l": "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809015", "l": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977605", "l": "Factor H displaces Bb (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58655", "l": "rifamycin SV ortho-naphthoquinone carboxamide <=> rifamycin SV para-naphthoquinone carboxamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003883", "l": "CTP synthase activity", "d": ["Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482962", "l": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358494", "l": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12681", "l": "creatinine + H(+) + H2O = N-methylhydantoin + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.4.21", "l": "\"creatinine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-205136", "l": "GTP-bound RAC contributes to JNK activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029271", "l": "PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61065", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-glucosamine => beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-ceramide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2130194", "l": "ABL phosphorylates WAVEs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809254", "l": "MTMR8 binds MTMR9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019769", "l": "low-affinity IgE receptor activity", "d": ["Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5444516", "l": "Formation of MSH2:MSH6 Complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046094", "l": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42402", "l": "L-histidyl-[protein] + lactose 6-phosphate(in) => lactose(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27828", "l": "L-homocysteine + succinate => hydrogen sulfide + O-succinyl-L-homoserine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3204311", "l": "AOX1 oxidises PXL to PDXate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050329", "l": "tetrahydroxypteridine cycloisomerase activity", "d": ["Catalysis of the reaction: tetrahydroxypteridine = H+ + xanthine-8-carboxylate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5653957", "l": "Rag dimer formation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.4.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74431", "l": "1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(out) + H(+)(out) = 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53950", "l": "ADP + gamma-L-glutamyl-[BtrI ACP] + phosphate => ATP + holo-[BtrI ACP] + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2201293", "l": "Endocytosis of TLR4:LY96:LPS:CD14 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15920", "l": "an aldopyranose + NAD(+) <=> aldono-1,5-lactone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17009", "l": "2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.26", "l": "\"o-succinylbenzoate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10876", "l": "4-hydroxybenzoate + H(+) = CO2 + phenol", "d": [], "t": []}, {"i": "EC:4.1.1.61", "l": "\"4-hydroxybenzoate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42022", "l": "H(+) + NADH + pregn-4-ene-3,11,20,21-tetraone => 11-dehydrocorticosterone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-428522", "l": "Inactivation of RAC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43780", "l": "2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867654", "l": "PTPN3 binds p-T183,Y185 MAPK12 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69598", "l": "Ubiquitination of phosphorylated Cdc25A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855178", "l": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44933", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75327", "l": "chloride(out) + D-tryptophan(out) + 2 Na(+)(out) = chloride(in) + D-tryptophan(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72183", "l": "creatinine(in) + H(+)(out) = creatinine(out) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047972", "l": "guanidinopropionase activity", "d": ["Catalysis of the reaction: 3-guanidinopropanoate + H2O = beta-alanine + urea."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78430", "l": "D-xylose(out) <=> D-xylose(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190413", "l": "Autocatalytic phosphorylation of FGFR2c (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77627", "l": "1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14237", "l": "10-deoxysarpagine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sarpagine", "d": [], "t": []}, {"i": "EC:1.14.14.136", "l": "\"deoxysarpagine hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700186", "l": "Autophosphorylation of point mutants of ALK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9818574", "l": "TASP1 cleaves KMT2A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-165718", "l": "mTORC1 phosphorylation of RPS6KB1 (S6K) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5251955", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14112", "l": "L-proline + NADP(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67408", "l": "gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] + thymol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29050", "l": "a menaquinone + 2 H(+)(in) + H2 <=> a menaquinol + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71854", "l": "glycocholate(out) <=> glycocholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8956099", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20013", "l": "carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate", "d": [], "t": []}, {"i": "EC:2.1.3.2", "l": "\"aspartate carbamoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0003989", "l": "acetyl-CoA carboxylase activity", "d": ["Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161293", "l": "Tropoelastin forms aggregate globules (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65208", "l": "(3S)-3-hydroxybutanoyl-CoA + H2O = (S)-3-hydroxybutanoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45120", "l": "(4R)-ipsdienol + NAD(+) = H(+) + ipsdienone + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38258", "l": "(S)-malate + succinyl-CoA <=> (S)-malyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2993769", "l": "Transfer of SUMO3 from E1 to UBE2I (UBC9) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-76397", "l": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9693243", "l": "RHOD translocates to the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9751201", "l": "p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8857925", "l": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23295", "l": "ATP + L-lombricine <=> ADP + H(+) + N-phospho-L-lombricine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944225", "l": "Association of procollagen type XVII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36623", "l": "3-phenylpyruvate + S-adenosyl-L-methionine = (3S)-2-oxo-3-phenylbutanoate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.281", "l": "\"phenylpyruvate C(3)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614583", "l": "PXLP-K212-CTH cleaves L-Cystathionine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757010", "l": "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6801675", "l": "PLK2 phosphorylates NPM1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2002460", "l": "P4HB binds Collagen chains (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66378", "l": "D-erythrose + phosphate => D-erythrose 4-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10553", "l": "D-glucose + O2 => 2-dehydro-D-glucose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58245", "l": "H2O + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] => ADP-D-ribose + L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68262", "l": "D-serine(out) + Na(+)(out) => D-serine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35074", "l": "4-methylphenol(in) <=> 4-methylphenol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77897", "l": "(1-deoxy-D-fructos-1-yl)amine + (S)-2-amino-6-oxohexanoate + H2O2 => H2O + N(6)-(1-deoxy-beta-D-fructopyranos-1-yl)-L-lysine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-74734", "l": "Re-integration of insulin receptor into plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52811", "l": "adenosine in U6 snRNA + S-adenosyl-L-methionine <=> H(+) + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9009072", "l": "STAT3 phosphorylation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71657", "l": "a thymidine in DNA + ADP-D-ribose => an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72917", "l": "D-fructopyranose(in) + Na(+)(in) => D-fructopyranose(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37943", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29145", "l": "a ubiquinone + 2 H(+)(out) + H2O + nitrite => a ubiquinol + 2 H(+)(in) + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:6.3.1.9", "l": "\"trypanothione synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351947", "l": "Nuclear translocation of catalytic domain of Mst3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65179", "l": "A + protoaustinoid A <=> AH2 + protoaustinoid B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8956026", "l": "CUL9:RBX1 ubiquitinates BIRC5 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432533", "l": "PP1 binds to phosphorylated TIM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10349", "l": "5-oxo-L-proline + ATP + 2 H2O => ADP + H(+) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8982019", "l": "Active G alpha (i)–i1/i2/i3 binds RGS proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375144", "l": "Interaction of NCAM1:GFRalpha-1 with GDNF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.130", "l": "\"tetraacyldisaccharide 4'-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351901", "l": "Caspase-mediated cleavage of MST3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5695980", "l": "ACAD10 dehydrogenates S-2MPDA-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24444", "l": "GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein]", "d": [], "t": []}, {"i": "EC:2.4.1.214", "l": "\"glycoprotein 3-alpha-L-fucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48825", "l": "GDP-beta-L-fucose + Lc4Cer => a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30245", "l": "2 H2O + 4 monodehydro-L-ascorbate radical => 4 L-ascorbate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53013", "l": "2,5-dichlorohydroquinone + 2 glutathione => chloride + chlorohydroquinone + glutathione disulfide + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5651657", "l": "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35762", "l": "8-O-methylsterigmatocystin + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> aflatoxin B1 + CO2 + 2 H(+) + H2O + methanol + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63821", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine) => H(+) + holo-[aryl-carrier protein] + petrobactin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047279", "l": "sn-glycerol-3-phosphate 1-galactosyltransferase activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H+ + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977317", "l": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-874087", "l": "SGT1 binds HSP90 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-914010", "l": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30537", "l": "biotin + H2O + NADP(+) => biotinate sulfoxide + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68969", "l": "mandelate + O2 => H2O2 + phenylglyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5692462", "l": "ATP13A1 transports Mn2+ from cytosol to ER lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2327909", "l": "DCN binds collagen I, II, III, VI fibrils (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632873", "l": "p-S10 CDKN1B translocates to the cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5334050", "l": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13511", "l": "diphosphate + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9647977", "l": "ICMT methylates S-Farn RAS proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350651", "l": "Caspase-mediated cleavage of MASK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1606288", "l": "SMPD4 hydrolyzes sphingomyelin (ER membrane) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40070", "l": "2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O <=> 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6814797", "l": "ENPP6 hydrolyzes lysophosphatidylcholine (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54084", "l": "7-cyano-7-carbaguanosine(15) in tRNA + H2O + L-glutamine = archaeosine(15) in tRNA + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.97", "l": "\"archaeosine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176474", "l": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034038", "l": "deoxyhypusine synthase activity", "d": ["Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45063", "l": "H2O + N-(9Z-octadecenoyl) ethanolamine <=> (9Z)-octadecenoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8868402", "l": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9667563", "l": "AVPR2 bind desmopressin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73375", "l": "biotin(out) + 2 Na(+)(out) = biotin(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482685", "l": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22240", "l": "H2O + methylenediurea = N-(carboxyaminomethyl)urea + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222755", "l": "Peroxynitrite is reduced to nitrite by Tpx (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1299359", "l": "Activation of TALK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31547", "l": "2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.96", "l": "\"4,4'-diapophytoene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0047264", "l": "heteroglycan alpha-mannosyltransferase activity", "d": ["Catalysis of the reaction: heteroglycan + GDP-mannose = alpha-D-mannosylheteroglycan + GDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5676912", "l": "Methionine is oxidised to methionine sulfoxide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8943959", "l": "MMP2, MMP9 cleave SCUBE3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39382", "l": "(2E,15Z,18Z,21Z,24Z)-triacontapentaenoyl-CoA + H(+) + NADPH <=> (15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018830", "l": "gamma-hexachlorocyclohexane dehydrochlorinase activity", "d": ["Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2022379", "l": "ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71269", "l": "chloride(in) + L-pipecolate(in) + 2 Na(+)(in) => chloride(out) + L-pipecolate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13667", "l": "3',5'-cyclic GMP + diphosphate => GTP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61646", "l": "2 Fe(III)-[cytochrome b5] + H2O + L-arginine => 2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52576", "l": "hexanoyl-CoA + NAD(+) = (2E)-hexenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41876", "l": "(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798739", "l": "Exocytosis of azurophil granule membrane proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864431", "l": "TFAP2A,TFAP2C homodimers stimulate CGB3 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64640", "l": "H2O + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose = lactose + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818576", "l": "Cleaved KMT2A dimers translocate to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71497", "l": "6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(out) => 6-(alpha-D-glucosaminyl)-(1-octadecanoyl,2-(9Z)-octadecenoyl-sn-glycero-3-phospho)-1D-myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5684008", "l": "NBN binds KPNA2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801762", "l": "REG3A oligomerize to form a pore complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018516", "l": "2,4-dichlorobenzoyl-CoA reductase activity", "d": ["Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP+ = 2,4-dichlorobenzoyl-CoA + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70137", "l": "28-nortyphasterol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxo-28-nortyphasterol + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686301", "l": "PALM-C100-CKAP4 binds SFTPAs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30064", "l": "2-demethylmenaquinol-8 + S-adenosyl-L-methionine => H(+) + menaquinol-8 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102069", "l": "zerumbone synthase activity", "d": ["Catalysis of the reaction: 8-hydroxy-alpha-humulene + NAD = zerumbone + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114284", "l": "Release of Cytochrome c from mitochondria (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56749", "l": "an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] => an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662466", "l": "XYLB phosphorylates D-xylulose (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202710", "l": "MERTK receptor binds ligands (Gas6 or Protein S) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-174124", "l": "Dephosphorylation of phospho-Cdh1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16621", "l": "dihydrosanguinarine + H(+) + O2 = H2O2 + sanguinarine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008779", "l": "acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102813", "l": "UDP-D-glucose:cyanidin 3-(p-coumaroyl)-glucoside 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-(p-coumaroyl)-glucoside = shisonin + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9717214", "l": "I(1,4,5)P3 binds ITPR3 tetramer (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9612509", "l": "SGK phosphorylates SRF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103010", "l": "gibberellin A53,2-oxoglutarate:oxygen oxidoreductase activity (GA97-forming)", "d": ["Catalysis of the reaction: gibberellin A53 + 2-oxoglutarate + O2 = gibberellin A97 + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10380", "l": "diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate", "d": [], "t": []}, {"i": "EC:2.4.2.10", "l": "\"orotate phosphoribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0003873", "l": "6-phosphofructo-2-kinase activity", "d": ["Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34794", "l": "2-hydroxyethylphosphonate + O2 <=> formate + H(+) + hydroxymethylphosphonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018836", "l": "RHOQ translocates to the Golgi-associated vesicle membranes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28683", "l": "L-aspartate + ubiquinone-8 = iminosuccinate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867135", "l": "CEACAM1,3,5,6 bind opa proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26377", "l": "GTP = cyclic pyranopterin phosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691411", "l": "BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5213464", "l": "RIPK1 is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351894", "l": "Caspase mediated cleavage of BAP31 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098769", "l": "TIMP family protein binding", "d": ["Binding to a member of the Tissue inhibitors of metalloproteinases (TIMPs) family. TIMPs are endogenous protein regulators of the matrix metalloproteinase (MMPs) family."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66776", "l": "ATP + H2O + uroporphyrin III(in) = ADP + H(+) + phosphate + uroporphyrin III(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50640", "l": "2-(2-methylsulfanyl)ethylmalate = 3-(2-methylsulfanyl)ethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.47", "l": "\"alpha-santonin 1,2-reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8964280", "l": "Active Gq binds BTK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5357776", "l": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-420584", "l": "Necl-1:Nectin 3 trans heterodimer interaction (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63697", "l": "SN-38 + UDP-alpha-D-glucuronate => H(+) + SN-38 O-beta-D-glucuronide + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11218", "l": "a 2'-deoxyribonucleoside 5'-diphosphate + ADP => a 2'-deoxyribonucleoside 5'-phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34290", "l": "2 L-dopa + O2 <=> 2 H2O + 2 L-dopaquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050210", "l": "prenyl-diphosphatase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + H2O = diphosphate + prenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76712", "l": "(15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione => (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50230", "l": "benzene-1,2,4-triol + FAD + H(+) + H2O => FADH2 + O2 + resorcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40966", "l": "4 2-aminophenol + 3 O2 <=> 2 2-aminophenoxazin-3-one + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24181", "l": "2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39977", "l": "2-oxobutanoate + NH4(+) => 2-iminobutanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-354273", "l": "AP-1 transcription factor forms a complex with STAT92E and DSP1 which displaces REL-68 from its target gene (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5690196", "l": "USP8 deubiquitinates RNF128 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31311", "l": "(2R)-3-phosphoglycerate + ADP-alpha-D-glucose = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8951766", "l": "Doubly neddylated UBA3:NAE1 binds AcM-UBE2F (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42324", "l": "2 oxidized [2Fe-2S]-[ferredoxin] + reduced coenzyme F420-(gamma-L-Glu)(n) = 3 H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.5.7.2", "l": "\"coenzyme F420 oxidoreductase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28240", "l": "H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + pseudobaptigenin => calycosin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-72103", "l": "Formation of pre-mRNPs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56889", "l": "UDP-4-dehydro-6-deoxy-alpha-D-glucose => UDP-4-dehydro-beta-L-rhamnose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9758682", "l": "AKR1C1 hydrogenates PREDN,PREDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9856510", "l": "STARD7 transports Q10 to plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9008258", "l": "NCOA3 binds ESR1:estrogen:TFGA gene (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-77069", "l": "RNA Polymerase II CTD (phosphorylated) binds to CE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033814", "l": "propanoyl-CoA C-acyltransferase activity", "d": ["Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60522", "l": "2 glycine + L-cystine => 2 H2O + L-cystine-bis-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000319", "l": "BORA binds PLK1 and AURKA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805638", "l": "KAT6A acetylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482900", "l": "PG is hydrolyzed to 1-acyl LPG by PLA2[1] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876283", "l": "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34756", "l": "H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine => D-glucose + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56947", "l": "AH2 + D-ribulose 5-phosphate <=> 1-deoxy-D-xylulose 5-phosphate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-449872", "l": "acetaldehyde [cytosolic] => acetaldehyde [mitochondrial] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45602", "l": "5-dehydro-4-deoxy-D-glucarate + H(+) => D-galactaro-1,4-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-187575", "l": "Ubiquitination of phospho-p27/p21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0035064", "l": "methylated histone binding", "d": ["Binding to a histone in which a residue has been modified by methylation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2545253", "l": "Deacetylation of cohesin (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0009041", "l": "UMP/dUMP kinase activity", "d": ["Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610038", "l": "Defective GALT does not transfer UMP to Gal1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928595", "l": "N-WASP binds ARP2/3 and G-actin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451309", "l": "Edited Kainate Receptor binds glutamate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37976", "l": "H(+) + homogentisate + phytyl diphosphate => 2-methyl-6-phytyl-1,4-benzene-1,4-diol + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047420", "l": "N-acyl-D-amino-acid deacylase activity", "d": ["Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63131", "l": "H2O + N-docosanoyl-ethanolamine <=> docosanoate + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6807214", "l": "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-377643", "l": "Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66577", "l": "3'-phosphoadenylyl sulfate + 4-isopropylphenol => 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9692376", "l": "BCL2 binds BCL2 antagonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20342", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose => 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9687638", "l": "MLKL binds IP4, IP5 and IP6  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8850539", "l": "Release of GNB5:RGS dimers from CCT/TRiC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59997", "l": "3-phenylpropanoate + H(+) + oxidized [electron-transfer flavoprotein] => (E)-cinnamate + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6788855", "l": "FN3KRP phosphorylates PsiAm, RibAm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1254251", "l": "ERBB4s80 binds YAP1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36999", "l": "(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8956040", "l": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23027", "l": "[(1->4)-beta-D-glucosyl](n) + phosphate <=> [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1676048", "l": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0010844", "l": "recombination hotspot binding", "d": ["Binding to a genomic region which promotes recombination."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24334", "l": "H2O + monacolin L carboxylate => 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54634", "l": "2-hydroxytetradecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + O2 + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "62.431179124761442", "identifiers": [{"i": "GO:0005262", "l": "calcium channel activity", "d": ["Enables the energy-independent facilitated diffusion of a calcium ion through a transmembrane aqueous pore or channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-913424", "l": "The SHC1:SHIP1 complex is stabilized by GRB2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69099", "l": "4-methylsulfanyl-2-oxobutanoate + L-kynurenine <=> H2O + kynurenate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454240", "l": "Recruitment of SYK to p-FCERI gamma subunit (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-381668", "l": "cAMP activates EPAC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38333", "l": "1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol => 1,3-di-(9Z-octadecenoyl)-glycerol + 1-(9Z-octadecenoyl)-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-983157", "l": "Interaction of E3 with substrate and E2-Ub complex (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2186780", "l": "Degradation of Ub-SMAD7 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654573", "l": "Activated FGFR1 binds SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41533", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1467457", "l": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76615", "l": "3-oxopropanoate + CoA + H2O + NAD(+) = acetyl-CoA + H(+) + hydrogencarbonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990002", "l": "methylglyoxal reductase (NADPH) (acetol producing) activity", "d": ["Catalysis of the reaction: hydroxyacetone + NADP+ = H+ + methylglyoxal + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32239", "l": "gamma-carotene = all-trans-beta-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.942687253280909", "identifiers": [{"i": "GO:0140104", "l": "molecular carrier activity", "d": ["Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72761", "l": "anthocyanin A8 + CoA => anthocyanin A6 + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9703437", "l": "FLT3 fusion dimers autophosphorylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70128", "l": "3-dehydro-6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] => 3-dehydro-6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416588", "l": "Activation of Rho by LARG and PDZ-RhoGEF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811508", "l": "ING2-bound EP300 acetylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8936599", "l": "RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57777", "l": "2-chloro-6-nitrotoluene + NADH + O2 => 4-chloro-3-methylcatechol + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62236", "l": "a cytidine(6-4)cytidine in DNA = a cytidine dimer in DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-375770", "l": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809264", "l": "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9032798", "l": "DOCK3 activates RAC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-426043", "l": "2-AG hydrolysis to arachidonate by MAGL (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000514", "l": "3-sulfino-L-alanine: proton, glutamate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-sulfino-L-alanine (cysteinesulfinate) (out) + H+(in) + L-glutamate(in) = 3-sulfino-L-alanine(in) + H+(out) + L-glutamate(out)."], "t": []}, {"i": "RHEA:70967", "l": "3-sulfino-L-alanine(out) + H(+)(in) + L-glutamate(in) = 3-sulfino-L-alanine(in) + H(+)(out) + L-glutamate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-209973", "l": "Tyrosine is diiodinated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58661", "l": "a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine => a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77801", "l": "2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]acetate + H(+) + H2O2 => N-(1-deoxy-beta-D-fructopyranos-1-yl)glycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63316", "l": "(9Z,12Z)-octadecadienoate + O2 = 9-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008139", "l": "nuclear localization sequence binding", "d": ["Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29627", "l": "alpha-maltohexaose + beta-maltose = alpha-maltoheptaose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390438", "l": "FAR2 reduces PalmCoA to HXOL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37779", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654596", "l": "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835385", "l": "DUS2 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43080", "l": "O2 + oleanolic aldehyde + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oleanolate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70236", "l": "a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol => an N-acylsphing-4-enine + cholesteryl 3-beta-D-galactoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839379", "l": "TGFBR3 binding to FGF2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8936481", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70671", "l": "N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757574", "l": "ALB binds PREDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46873", "l": "1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IIA => a 2-acyl-sn-glycero-3-phosphocholine + lipid IIB", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13939", "l": "3,4-dihydroxybenzoate + NAD(+) + sulfite => 4-sulfobenzoate + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62566", "l": "(4S)-perillyl alcohol + AH2 => (4S)-limonene + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50309", "l": "17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] => 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9823995", "l": "Expression of E-cadherin (CDH1) in definitive endoderm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72621", "l": "Ribosomal scanning  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78413", "l": "2-aminobenzimidazole + CO2 + methanol => carbendazim + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928639", "l": "p-EFNB binds GRB4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21002", "l": "1,2,3,5-tetrahydroxybenzene + 1,3,5-trihydroxybenzene => 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54493", "l": "1,2-diheptanoyl-sn-glycero-3-phosphocholine + 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine => 1-heptanoyl-2-hexanoyl-sn-glycero-3-phosphoethanolamine + 1-hexanoyl-2-heptanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11956", "l": "cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49530", "l": "(ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+) => (ethylene terephthalate)(n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8951764", "l": "Transfer of NEDD8 to AcM-UBE2F (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30093", "l": "a ubiquinol + NH4(+) + pyruvate => a ubiquinone + D-alanine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40245", "l": "3-oxohexadecanoyl-CoA + H(+) + NADH => (3R)-hydroxyhexadecanoyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416683", "l": "SEMA3E binds to PLXND1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69366", "l": "CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine => 6-diazo-5-oxo-L-norleucine + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18388", "l": "acetone + 2 ATP + 3 H2O + hydrogencarbonate <=> acetoacetate + 2 AMP + 4 H(+) + 4 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9733316", "l": "p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22232", "l": "H(+) + NADPH + presqualene diphosphate = diphosphate + NADP(+) + squalene", "d": [], "t": []}, {"i": "EC:1.3.1.96", "l": "\"Botryococcus squalene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20588", "l": "loganin + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + secologanin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214878", "l": "PLL kinase binds to TL:WEK:MYD88:TUB 'signalling complex' (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025969", "l": "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70820", "l": "L-homoarginine(in) + L-ornithine(out) => L-homoarginine(out) + L-ornithine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22441", "l": "UDP-alpha-D-galactose + UDP-N-acetyl-alpha-D-glucosamine => H(+) + UDP-N-acetyl-6-(alpha-D-galactose-1-phospho)-alpha-D-glucosamine + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5229111", "l": "AP4 transports APP from trans-Golgi network to endosome lumen (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102638", "l": "[1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase activity", "d": ["Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl diphosphate = [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11641", "l": "a (2R,3R)-flavan-3-ol + 2 NAD(+) => an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705961", "l": "nsp15 cleaves viral poly(U)-RNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59551", "l": "N,N',N''-triacetylchitotriose + O2 <=> H2O2 + N,N',N''-triacetylchitotriono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60413", "l": "H2O + monoglucosyl-enterobactin => [N-(2,3-dihydroxybenzoyl)-L-seryl]2-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684250", "l": "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-74255", "l": "Guanine + H2O => Xanthine + NH4+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15411", "l": "1-O-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-alkyl-sn-glycero-3-phosphocholine => 1-alkyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0030366", "l": "molybdopterin synthase activity", "d": ["Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64210", "l": "a fatty acid + L-glutamine => an N-(fatty acyl)-L-glutamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39103", "l": "ATP + H2O + sitosterol(in) = ADP + H(+) + phosphate + sitosterol(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952716", "l": "SLC38A9 binds Ragulator:Rag dimers (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987266", "l": "IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450222", "l": "Active p38 MAPK phosphorylates MAPKAPK2 or 3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1358797", "l": "Ubiquitinated RNF41 binds P-USP8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0004114", "l": "3',5'-cyclic-nucleotide phosphodiesterase activity", "d": ["Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9840415", "l": "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73597", "l": "CTP(in) + dUMP(out) => CTP(out) + dUMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193682", "l": "gamma-secretase cleaves the p75NTR transmembrane domain (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29223", "l": "menaquinone-8 + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + menaquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381500", "l": "Cathepsin G proteolyzes IGF:IGFBP3:ALS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5669035", "l": "TNFSF11 binds TNFRSF11A, B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-514604", "l": "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77530", "l": "hexanal + hydrogen cyanide <=> (2S)-2-hydroxyheptanenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46515", "l": "an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9662708", "l": "CREB binds IL6 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6790454", "l": "SUMOylation of XPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21440", "l": "a long-chain fatty aldehyde + H(+) + 2 NADPH + O2 = a long-chain alkane + formate + H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61168", "l": "quercetin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = H(+) + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804724", "l": "MDM2 ubiquitinates phosphorylated MDM4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60456", "l": "ATP + UTP = 3',3'-cUAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429157", "l": "ABCC4 accumulation of dense granule contents (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14201", "l": "D-lyxose = D-xylulose", "d": [], "t": []}, {"i": "EC:5.3.1.15", "l": "\"D-lyxose ketol-isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5358599", "l": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5655965", "l": "POLK and POLZ cooperate in elongation of mispaired primer termini (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64209", "l": "an N-(fatty acyl)-L-glutamine + H2O => a fatty acid + L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65190", "l": "berkeleydione + CO2 + H2O + succinate => 2-oxoglutarate + berkeleyone B + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55846", "l": "calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP => calcidiol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855131", "l": "VLDLR:PCSK9 binds Clathrin-coated vesicles (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034882", "l": "cis-aconitamide amidase activity", "d": ["Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0003865", "l": "3-oxo-5-alpha-steroid 4-dehydrogenase activity", "d": ["Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805755", "l": "EHMT1:EHMT2 dimethylates TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111930", "l": "Adenylate cyclase produces cAMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392202", "l": "Dissociation of the P2Y purinoceptor 12:Gi complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696958", "l": "USP44 deubiquitinates CDC20 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9736953", "l": "FURIN translocates to the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696197", "l": "NUDT2 hydrolyses GP4G to GTP, GMP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73133", "l": "7,8-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine => 8-hydroxy-7-methoxyflavone + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5685156", "l": "ATR phosphorylates RPA2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66109", "l": "2-oxobutanoate + L-cysteine => (2S)-2-aminobutanoate + 2-oxo-3-sulfanylpropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67924", "l": "3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015495", "l": "gamma-aminobutyric acid:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-877269", "l": "SOCS-1 and SOCS-3 binds to p-JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9748979", "l": "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18858", "l": "lithocholate + O2 + reduced [NADPH--hemoprotein reductase] => 6beta-hydroxylithocholate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58891", "l": "4-aminobenzoate + AH2 + 2 O2 <=> 4-nitrobenzoate + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37655", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70468", "l": "2-oxoglutarate + a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O + O2 => a 2'-deoxycytidine in double-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483211", "l": "PC:PITPNB is transported from the Golgi membrane to the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9640237", "l": "CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-893616", "l": "glutamine + pyruvate => 2-oxoglutaramate + alanine (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1855163", "l": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43279", "l": "a ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine <=> a ganglioside GalNAc-GD1a + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69055", "l": "H(+) + N(omega)-methyl-L-arginine + 2 NADH + 3 O2 <=> 3 H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline + 2 NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-947591", "l": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53362", "l": "H(+) + NADPH + uridine(47) in tRNA => 5,6-dihydrouridine(47) in tRNA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21582", "l": "(R)-acetoin + CO2 => (2S)-2-acetolactate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5603379", "l": "TPMT does not transfer CH3 from AdoMet to 6MP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24009", "l": "ATP + hypotaurocyamine => ADP + H(+) + N(omega)-phosphohypotaurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9603420", "l": "Activated NTRK3 promotes SRC autophosphorylation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482894", "l": "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11698", "l": "H(+) + S-adenosyl-L-homocysteine + staurosporine => 3'-demethylstaurosporine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0046997", "l": "oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin."], "t": []}, {"i": "EC:1.5.8.-", "l": "\"With a flavin as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4641129", "l": "AXIN is ubiquitinated by SMURF2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-442422", "l": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5579023", "l": "NCOA2(869-1464) binds KAT6A(1-1118) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-112437", "l": "Formation of NELF complex  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40442", "l": "6-sulfo-beta-D-quinovose <=> 6-deoxy-6-sulfo-D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182795", "l": "RNase H-mediated degradation of the template strand (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218822", "l": "CRK binds BCAR1 and or PXN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76883", "l": "3-aminobutan-1-ol + H2O + NAD(+) = 4-hydroxybutan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9794120", "l": "ABCG2 transports Cipro from intestinal cell to extracellular space (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77956", "l": "cholesterol + UDP-alpha-D-galactose => cholesteryl 3-beta-D-galactoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018907", "l": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52311", "l": "2-hydroxyglutarate + NADP(+) <=> 2-oxoglutarate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26078", "l": "methanesulfonate + NADH + O2 => formaldehyde + H2O + NAD(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61487", "l": "a cytidine in rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-209772", "l": "Thyroxine is deiodinated to triiodothyronine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5661124", "l": "JMJD6 demethylates MeR4-HIST1H4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0030899", "l": "calcium-dependent ATPase activity", "d": ["Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75089", "l": "32-oxo-24,25-dihydrolanosterol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 32-hydroxy-24,25-dihydrolanosterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6811422", "l": "NSF ATPase activity dissociates cis-SNARE at the ER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71189", "l": "AFMID hydrolyses NFK to L-KYN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6811429", "l": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9607304", "l": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654413", "l": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-879907", "l": "Tyrosine kinases phosphorylate the receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0020037", "l": "heme binding", "d": ["Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9641089", "l": "Parkin binds Ub:UBE2N:UBE2V1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16964", "l": "epsilon-(gamma-L-glutamyl)-L-lysine <=> 5-oxo-L-proline + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047427", "l": "cyanoalanine nitrilase activity", "d": ["Catalysis of the reaction: 3-cyano-L-alanine + 2 H2O + H+ = L-aspartate + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9679421", "l": "PDCD1 binds PDCD1 inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-975902", "l": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-113503", "l": "PP2A mediated localization of RB1 protein in chromatin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64093", "l": "3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H(+) + NADPH + O2 => 3-(2,4-dioxopentyl)-2,3,6,8,9-pentahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9864415", "l": "AAC1 imports a proton (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19693", "l": "5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+) = 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.100", "l": "\"5-formyl-3-hydroxy-2-methylpyridine 4-carboxylate 5-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218839", "l": "DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54151", "l": "1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene <=> 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080116", "l": "glucuronoxylan glucuronosyltransferase activity", "d": ["Catalysis of the transfer of glucuronate to the xylan backbone of glucuronoxylan molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8862380", "l": "HSD17B13 binds lipid droplets (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13893", "l": "H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate = ADP + AMP + 2 H(+)", "d": [], "t": []}, {"i": "EC:3.6.1.29", "l": "\"bis(5'-adenosyl)-triphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-629595", "l": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654569", "l": "Activated FGFR1 binds FRS2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4084989", "l": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0034987", "l": "immunoglobulin receptor binding", "d": ["Binding to one or more specific sites on an immunoglobulin receptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-71593", "l": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868661", "l": "Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38046", "l": "2 H(+) + hexadecanoyl-[ACP] + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> (4Z)-hexadecenoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34183", "l": "alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP-alpha-D-abequose = alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50977", "l": "prostaglandin D2(out) => prostaglandin D2(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36991", "l": "phosphate + UMP = alpha-D-ribose 1,5-bisphosphate + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1963563", "l": "MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48568", "l": "3-chlorocatechol + O2 = (2E,4Z)-2-chloromuconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015454", "l": "light-driven active monoatomic ion transmembrane transporter activity", "d": ["Active transport of an ion across a membrane, driven by light."], "t": []}, {"i": "TCDB:3.E", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046563", "l": "methanol oxidase activity", "d": ["Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-112437", "l": "Formation of NELF complex  (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33468", "l": "5-dehydroepisterol + H(+) + NADPH + O2 => ergosta-5,7,22,24(28)-tetraen-3beta-ol + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697043", "l": "Protease binds protease inhibitors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63651", "l": "(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15545", "l": "(3S)-citramalate = acetate + pyruvate", "d": [], "t": []}, {"i": "EC:4.1.3.22", "l": "\"citramalate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47704", "l": "H(+) + iso-precytochalasin + NADPH + O2 = cytochalasin Z16 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450474", "l": "MK2 phosphorylates BRF1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5689649", "l": "BAP1 binds BRCA1:BARD1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019143", "l": "3-deoxy-manno-octulosonate-8-phosphatase activity", "d": ["Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H2O = 3-deoxy-D-manno-octulosonate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43350", "l": "cholesteryl (9Z-octadecenoate)(out) => cholesteryl (9Z-octadecenoate)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9027275", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-429415", "l": "SYK binds to integrin alphaIIb beta3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791143", "l": "Expression of YIF1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015401", "l": "urea:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855208", "l": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165179", "l": "Formation of TSC1:TSC2 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5358484", "l": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8943007", "l": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10788", "l": "2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.13", "l": "\"dehydrogluconokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2248891", "l": "M6PR transports activated ARSA to the lysosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78791", "l": "D-cysteine + H2O + O2 = 2-oxo-3-sulfanylpropanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429613", "l": "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8983841", "l": "STAT1 associates with IL6ST:IL6ST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102945", "l": "soyasapogenol B UDP-glucosyl transferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + soyasapogenol B = UDP(3-) + a soyasapogenol B monoglucoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211350", "l": "PDX1-dependent synthesis of NKX6-1 protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73528", "l": "TDP(out) + UTP(in) => TDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78258", "l": "D-ornithine + H2O + O2 <=> 5-amino-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5607724", "l": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70419", "l": "3,4-dihydroxyphenylacetyl-CoA + H2O = 3,4-dihydroxyphenylacetate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-162914", "l": "Myristoylation of Nef (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168897", "l": "LRP1 (CD91) binds Hemopexin:heme (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661126", "l": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9630993", "l": "RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29432", "l": "ATP + phosphate => ADP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48018", "l": "2-hydroxy-5-methylquinone + H(+) + H2O + NAD(+) + nitrite => 4-methyl-5-nitrocatechol + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29754", "l": "acetoacetate(in) <=> acetoacetate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5610742", "l": "SCF(beta-TrCP) ubiquitinates p-GLI1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71303", "l": "chloride(out) + L-methionine(out) + 2 Na(+)(out) = chloride(in) + L-methionine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38704", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-877308", "l": "Dephosphorylation of JAKs by PTPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3465429", "l": "FLIP(S) and procaspase-8 form heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30402", "l": "alpha-carotene + O2 + reduced [NADPH--hemoprotein reductase] <=> alpha-cryptoxanthin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-449715", "l": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55786", "l": "all-trans-4-oxoretinoate 1-O-(beta-D-glucuronate) + UDP => all-trans-4-oxoretinoate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54620", "l": "2-oxoglutarate + eicosanoyl-CoA + O2 = 2-hydroxyeicosanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29009", "l": "H(+)(out) + Mn(2+)(out) => H(+)(in) + Mn(2+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0052834", "l": "inositol monophosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49732", "l": "H(+) + O2 + violaceinate = CO2 + H2O + violacein", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22023", "l": "ATP + H2O + molybdate(out) <=> ADP + H(+) + molybdate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10054", "l": "4-methyl-2-oxopentanoate + H(+) + NADH => (R)-2-hydroxy-4-methylpentanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19180", "l": "L-lysine <=> (3S)-3,6-diaminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51211", "l": "20-hydroxy-leukotriene B4 + NADP(+) <=> 12-oxo-20-hydroxy-leukotriene B4 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64274", "l": "benzaldehyde + L-alanine => benzylamine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839378", "l": "TGFBR3 binding to ARRB1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41310", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O <=> (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72715", "l": "(R)-dihydrolipoate + ATP + H(+) = diphosphate + N(6)-[(R)-dihydrolipoyl]-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13312", "l": "H2O + NAD(+) + vanillin <=> 2 H(+) + NADH + vanillate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-398185", "l": "LARG binds plexin B1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158832", "l": "The acetyl group from acetyl-CoA is transferred to the NAT2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-435349", "l": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5099886", "l": "WNT5A binding to FZD promotes PRICKLE1 degradation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9735946", "l": "Anti-MET small tyrosine kinase inhibitors bind MET (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6800198", "l": "HPN heterodimer cleaves pro-MST1 to form MST1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70581", "l": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-874087", "l": "SGT1 binds HSP90 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-190519", "l": "Internalization of gap junction plaques (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877612", "l": "DENND1s exchange GTP for GDP on RAB35 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27416", "l": "2-oxoglutarate + codeine + O2 <=> CO2 + formaldehyde + morphine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.76", "l": "\"prenyl-diphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8987270", "l": "p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29777", "l": "ADP + alpha-D-ribose 1,5-bisphosphate + H(+) => alpha-D-ribose 1-phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49989", "l": "acetone + H(+) + NADPH + O2 => H2O + methyl acetate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0140939", "l": "histone H4 methyltransferase activity", "d": ["Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28850", "l": "Li(+)(in) + melibiose(in) <=> Li(+)(out) + melibiose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632646", "l": "SMURF1/2 bind PTCH1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14495", "l": "ADP-D-ribose + L-arginyl-[dinitrogen reductase] => H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40514", "l": "(2S)-3-sulfopropanediol + NAD(+) <=> (2S)-3-sulfolactaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0004102", "l": "choline O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70666", "l": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6784224", "l": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9654521", "l": "Calmodulin dissociates KRAS4B from the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371503", "l": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426015", "l": "Na+/H+ exchanger transport (at trans-golgi membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1678842", "l": "Competitive inhibition of translation initiation by ISGylated 4EHP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708466", "l": "p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18750", "l": "[protein]-dithiol + NAD(+) => [protein]-disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4085350", "l": "SUMOylation of UBE2I with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174132", "l": "Free APC/C phosphorylated by Cyclin B:Cdc2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61732", "l": "steviol + UDP-alpha-D-glucose = H(+) + steviolmonoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61702", "l": "AMP + glycyl-[peptidyl-carrier protein] + H(+) => glycyl-5'-AMP + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65773", "l": "2 H(+) + isoproturon + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9696266", "l": "RND2 binds effectors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012349", "l": "ME3 tetramer decarboxylates MAL to PYR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1676164", "l": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483186", "l": "PC is converted to PS by PTDSS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.4", "l": "\"phospholipase A2\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052845", "l": "inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity", "d": ["Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-481044", "l": "Surface deployment of platelet alpha granule membrane components (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1602446", "l": "PA is hydrolyzed to 1-acyl LPA by PLA2[15] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2685505", "l": "TPCN1/2 transport lysosomal Ca2+ to cytosol  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31122", "l": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA <=> (2E)-2-methylbut-2-enoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0022878", "l": "protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444606", "l": "T1R2/T1R3 dimer is a sweet taste receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-392263", "l": "AVP(20-28) binds AVPR2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195283", "l": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by GSK-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13844", "l": "Fe(II)2-[transferrin] + H(+) + NAD(+) <=> Fe(III)2-[transferrin] + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63854", "l": "(2R)-2-hydroperoxydodecanoate => dodecanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607756", "l": "TRAF6 oligomer autoubiquitinates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16156", "l": "a primary methyl amine + H2O + O2 <=> an aldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5669250", "l": "PAK1 phosphorylates FLNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29877", "l": "H(+) + L-serine + sn-glycerol 3-phosphate => H2O + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35624", "l": "D-glutamate + D-glutamine => gamma-D-glutamyl-D-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-450434", "l": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12713", "l": "a nucleoside 5'-phosphate + ATP = a 5'-phosphonucleoside 3'-diphosphate + AMP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.6.4", "l": "\"nucleotide diphosphokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1306969", "l": "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3318571", "l": "Defective MMADHC does not bind MMACHC:B12r (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854051", "l": "SCF-FBXL18 ubiquitinates FBXL7 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008887", "l": "glycerate kinase activity", "d": ["Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-164617", "l": "Elongation of Extended Telomeric Chromosome End (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62588", "l": "2-hydroxy-2-(4-hydroxyphenyl)acetate + H(+) = 4-hydroxybenzyl alcohol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050230", "l": "purine imidazole-ring cyclase activity", "d": ["Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-266046", "l": "GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.4", "l": "\"fructokinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798373", "l": "MDM2 ubiquitinates DYRK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517705", "l": "p-S318,221-HuR binds mRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54228", "l": "2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine = 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50410", "l": "2-heptyl-4(1H)-quinolone + H2O => 1-(2-aminophenyl)decane-1,3-dione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5658430", "l": "NF1 is degraded by the proteasome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32094", "l": "3-O-alpha-L-mycarosylerythronolide B + dTDP-alpha-D-desosamine <=> dTDP + erythromycin D + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3000112", "l": "CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939670", "l": "RUNX2:CBFB binds the ITGA5 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3900047", "l": "SUMOylation of DDX17 with SUMO1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24011", "l": "ATP + hypotaurocyamine <=> ADP + H(+) + N(omega)-phosphohypotaurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37735", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-L-serine = 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5668629", "l": "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32688", "l": "(2E)-geranyl diphosphate => diphosphate + tricyclene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15872", "l": "2-oxoglutarate + D-alanine <=> D-glutamate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5691000", "l": "TFIIH binds GG-NER site to form a verification complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24727", "l": "N-demethylindolmycin + S-adenosyl-L-methionine => H(+) + indolmycin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50695", "l": "ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate <=> ADP + alpha-maltose 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028598", "l": "Phosphorylation of YAP by LATS1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106355", "l": "4-hydroxybenzoate 3-monooxygenase (NADH) activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD+."], "t": []}, {"i": "RHEA:19473", "l": "4-hydroxybenzoate + H(+) + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12474", "l": "ethylamine + glyoxylate + H2O2 => H2O + N-ethylglycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3249379", "l": "p-S407-STAT6 is phosphorylated at Tyr641 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78122", "l": "a 1,3-diacyl-2-(9Z,12Z-octadecadienoyl)-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base <=> a 1,3-diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799199", "l": "COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0046568", "l": "3-methylbutanal reductase [NAD(P)H] activity", "d": ["Catalysis of the reaction: 3-methylbutanol + NAD(P)+ = 3-methylbutanal + NAD(P)H + H+. 3-methylbutanal is also known as isovaleraldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019112", "l": "phenanthrol glycosyltransferase activity", "d": ["Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56501", "l": "(R)-3,5-bisphosphomevalonate + H(+) => CO2 + isopentenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31987", "l": "(S)-2,3-epoxysqualene = baruol", "d": [], "t": []}, {"i": "EC:5.4.99.57", "l": "\"baruol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177924", "l": "Dephosphorylation of Gab1 by SHP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41048", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1,2-di-(9Z-octadecenoyl)-sn-glycerol => 1,2-di-(9Z)-octadecenoyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59575", "l": "H2O + L-homocarnosine <=> 4-aminobutanoate + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64740", "l": "H2O + S-(1-hydroxy-3-methylhexan-3-yl)-L-cysteine = 3-methyl-3-sulfanylhexan-1-ol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033937", "l": "3-deoxy-2-octulosonidase activity", "d": ["Catalysis of the endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39414", "l": "(3R)-hydroxy-(21Z,24Z,27Z,30Z)-hexatriacontatetraenoyl-CoA <=> (2E,21Z,24Z,27Z,30Z)-hexatriacontapentaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41322", "l": "(9Z)-octadecenoate + 2-acetyl-sn-glycero-3-phosphocholine + H(+) => 1-O-(9Z)-octadecenoyl-2-O-acetyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1676185", "l": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732629", "l": "PPARG binds PPARG agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17330", "l": "(1R,2S,4R)-borneol + NAD(+) => (1R,4R)-camphor + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50623", "l": "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose <=> alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10422", "l": "L-alanine + sulfoacetaldehyde => pyruvate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8850594", "l": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102834", "l": "1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity", "d": ["Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-426522", "l": "Nonendonucleolytic RISC binds exactly matching target RNAs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21024", "l": "CoA + glyoxylate + NADP(+) = H(+) + NADPH + oxalyl-CoA", "d": [], "t": []}, {"i": "EC:1.2.1.17", "l": "\"glyoxylate dehydrogenase (acylating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9766645", "l": "CUL3:RBX1 ubiquitinates KEAP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018828", "l": "halohydrin hydrogen-halide-lyase A activity", "d": ["Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29929", "l": "(R)-pantothenate(out) + Na(+)(out) => (R)-pantothenate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33084", "l": "dehypoxanthine futalosine + S-adenosyl-L-methionine => 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70920", "l": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73132", "l": "8-hydroxy-7-methoxyflavone + S-adenosyl-L-methionine => 7,8-dimethoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68950", "l": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250189", "l": "Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19071", "l": "glutathione + methylglyoxal => (R)-S-lactoylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19729", "l": "acetoacetate + H(+) = acetone + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.4", "l": "\"acetoacetate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45601", "l": "D-galactaro-1,4-lactone => 5-dehydro-4-deoxy-D-glucarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-176517", "l": "SULTs transfer (SO4)2- group to PREG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110322", "l": "Formation of Pol zeta complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8864307", "l": "TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "83.08573956302773", "identifiers": [{"i": "GO:0042285", "l": "xylosyltransferase activity", "d": ["Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-112429", "l": "Formation of FACT complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4332359", "l": "Active calmodulin binds CAMK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36345", "l": "2-methylsulfanyl-N(6)-(cis-4-hydroxy-Delta(2)-isopentenyl)adenosine in tRNA + H2O + NADP(+) => 2-methylsulfanyl-N(6)-(Delta(2)-isopentenyl)adenosine in tRNA + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6809680", "l": "MTMR12 binds MTM1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69378", "l": "2-oxododecanoate + H2O2 => 2-hydroxydodecanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26100", "l": "(4R)-limonene + H(+) + NADPH + O2 <=> H2O + limonene 1,2-epoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67429", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O => 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40665", "l": "2-aminoprop-2-enoate + H2O => L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45344", "l": "a globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a globoside NORint (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9796067", "l": "PRKAA2 phosphorylates nuclear NFE2L2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21110", "l": "2-methylbutanal + CO2 => (S)-3-methyl-2-oxopentanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052724", "l": "inositol hexakisphosphate 3-kinase activity", "d": ["Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5686900", "l": "TP53BP1 recruits DCLRE1C to ATM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950387", "l": "CANX binds EBI3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61335", "l": "ATP + H2O + indoxyl sulfate(in) <=> ADP + H(+) + indoxyl sulfate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.1.5", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41348", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71821", "l": "L-thyroxine(in) => L-thyroxine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22099", "l": "phosphate + RNA(n+1) <=> a ribonucleoside 5'-diphosphate + RNA(n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25003", "l": "H(+) + N,N-dihydroxy-L-phenylalanine <=> (E)-phenylacetaldehyde oxime + CO2 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1234171", "l": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74744", "l": "kaempferol + S-adenosyl-L-methionine => 3-O-methylkaempferol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11853", "l": "phosphate + S-methyl-5'-thioadenosine => adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.47", "l": "\"[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624126", "l": "ARL6:GTP and the BBSome bind ciliary cargo (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.31", "l": "\"3-hydroxyisobutyrate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.247", "l": "\"[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9794270", "l": "SLCO1A2 transports Cipro(1+) into the cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696945", "l": "USP33 deubiquitinates CCP110,ARRB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17404", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate <=> 4-carboxy-2-hydroxy-cis,cis-muconate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39702", "l": "(R)-3-hydroxy-(13Z)-eicosenoyl-CoA <=> (2E,13Z)-eicosadienoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30086", "l": "4 Cu(+) + 4 H(+) + O2 <=> 4 Cu(2+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-140664", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20771", "l": "3-phosphonopyruvate + H(+) <=> CO2 + phosphonoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-561059", "l": "OAT2 and OAT4 mediate transport of sulphate conjugates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-450984", "l": "IDH2 dimer decarboxylates isocitrate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-446277", "l": "RhCG mediates ammonium efflux out of kidney collecting duct cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.187358309157389", "identifiers": [{"i": "GO:0019789", "l": "SUMO transferase activity", "d": ["Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034283", "l": "syn-stemod-13(17)-ene synthase activity", "d": ["Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62406", "l": "CO2 + H2O + pentadecanoate => (R)-2-hydroxyhexadecanoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982765", "l": "Growth hormone forms dimers and oligomers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602966", "l": "Defective FMO3 does not N-oxidise TMA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72901", "l": "proatranorin I + S-adenosyl-L-homocysteine => 4-O-demethylbarbatate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-390846", "l": "D2D3,4 bind to DA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170126", "l": "Phosphorylation of Cyclin B1 in the CRS domain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6786048", "l": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77412", "l": "acrolein + hydrogen cyanide => (2S)-2-hydroxybut-3-enenitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9858734", "l": "MITF-M-dependent TERT expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018778", "l": "RHOBTB1 binds interacting proteins at the endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45962", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 24,25-dihydrolanosterol + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15666", "l": "aldehydo-D-glucose + L-lysyl-[protein] => H2O + N(6)-(D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78316", "l": "ADP + ATP => adenosine 5'-tetraphosphate + AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-170824", "l": "glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33249", "l": "1-pyrroline + H2O2 + NH4(+) => O2 + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48694", "l": "H(+) + octanoate + octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol => 1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.012360833342299", "identifiers": [{"i": "GO:0004743", "l": "pyruvate kinase activity", "d": ["Catalysis of the reaction: = ADP + H+ + phosphoenolpyruvate => ATP + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "65.719115501493548", "identifiers": [{"i": "GO:0052689", "l": "carboxylic ester hydrolase activity", "d": ["Catalysis of the hydrolysis of a carboxylic ester bond."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420724", "l": "CASR binds Ca2+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16449", "l": "acetyl-CoA + kanamycin B = CoA + H(+) + N(6')-acetylkanamycin B", "d": [], "t": []}, {"i": "EC:2.3.1.82", "l": "\"aminoglycoside 6'-N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36199", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-O-(1Z-alkenyl)-sn-glycerol + H(+) + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654608", "l": "Activated FGFR2:p-FRS bind to PPTN11 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48832", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50060", "l": "ATP + glycochenodeoxycholate(in) + H2O = ADP + glycochenodeoxycholate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902557", "l": "5'-adenylyl sulfate transmembrane transporter activity", "d": ["Enables the transfer of 5'-adenylyl sulfate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8878787", "l": "ALPI dimer hydrolyses phosphate monoesters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5694423", "l": "NSF and SNAPs bind cis-SNARE complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4341016", "l": "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-176604", "l": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043183", "l": "vascular endothelial growth factor receptor 1 binding", "d": ["Binding to a vascular endothelial growth factor receptor 1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-177939", "l": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21677", "l": "2 dimethylallyl diphosphate => (R)-lavandulyl diphosphate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952039", "l": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74788", "l": "L-histidyl-L-proline diketopiperazine(in) => L-histidyl-L-proline diketopiperazine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3656254", "l": "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75899", "l": "1,2-diacyl-sn-glycero-3-phospho-N-acyl-L-serine + H2O = 1-acyl-sn-glycero-3-phospho-N-acyl-L-serine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9858589", "l": "DLD dimer dehydrogenates dihydrolipoyl (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1295599", "l": "SPRY2 translocates to the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792871", "l": "CCNG1 recruits PP2A-PPP2R5C to MDM2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.151", "l": "\"xyloglucan-specific endo-beta-1,4-glucanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-451377", "l": "Interaction of IQGAP1 with nephrin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8852129", "l": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8870354", "l": "SLC36A4 transports extracellular L-Pro to the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78707", "l": "H2O + N-terminal L-arginyl-L-amino acid-[protein] = an N-terminal L-alpha-aminoacyl-[protein] + L-arginine", "d": [], "t": []}, {"i": "EC:3.4.11.27", "l": "\"archaeal arginyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51790", "l": "2-hydroxybenzoyl-CoA + AMP + H(+) => 2-hydroxybenzoyl-5'-AMP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76748", "l": "hexadecane + O2 + reduced [NADPH--hemoprotein reductase] => 9-hexadecanol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61577", "l": "(4R,5R)-4,5-dihydroxycyclohex-2-ene-1-carbonyl-CoA + NADP(+) => (3R,4R)-3,4-dihydroxycyclohexa-1,5-diene-1-carbonyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.115", "l": "\"branched-dextran exo-1,2-alpha-glucosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13831", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH => GDP-alpha-D-rhamnose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13727", "l": "CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate => acetyl-CoA + alpha-D-glucosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9009533", "l": "TBP and TFIIA bind TATA box on  ESR1:estrogen bound TFF1 gene promoter (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41340", "l": "(6Z,9Z,12Z)-octadecatrienoate + O2 = 10R-hydroperoxy-(6Z,8E,12Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848484", "l": "PLA2s hydrolyze phospholipids at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33807", "l": "(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10925", "l": "cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide => trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59675", "l": "D-maltotriose + O2 <=> D-maltotriono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18029", "l": "2 ATP + hydrogencarbonate + NH4(+) = 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.16", "l": "\"carbamoyl-phosphate synthase (ammonia)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0016716", "l": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen", "d": ["Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor."], "t": []}, {"i": "EC:1.14.18.-", "l": "\"With another compound as one donor, and incorporation of one atom of oxygen\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51816", "l": "ATP(in) + CoA(in) + dodecanoate(out) + H(+)(out) = AMP(in) + diphosphate(in) + dodecanoyl-CoA(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20012", "l": "2-hydroxy-2-methylpropanenitrile + UDP-alpha-D-glucose <=> H(+) + linamarin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005043", "l": "netrin receptor activity involved in chemorepulsion", "d": ["Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.18", "l": "\"aspergillopepsin I\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647632", "l": "CASP3 cleaves GSDME (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798751", "l": "Exocytosis of azurophil granule lumen proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102812", "l": "4-coumaroyl-CoA:cyanidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity", "d": ["Catalysis of the reaction: 4-coumaryl-CoA + cyanidin 3-O-beta-D-glucoside betaine = cyanidin 3-(p-coumaroyl)-glucoside + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35324", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) => (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63600", "l": "H2O + neocasomorphin = L-isoleucine + neocasomorphin-(1-5)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008658", "l": "penicillin binding", "d": ["Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.25", "l": "\"mugineic-acid 3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2168884", "l": "Ferriheme is transferred from Methemoglobin to Hemopexin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938108", "l": "SERPINB13 binds cathepsin L (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-888548", "l": "ALDH5A1 dehydrogenates SUCCSA to SUCCA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035730", "l": "S-nitrosoglutathione binding", "d": ["Binding to S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37361", "l": "D-glucosamine 6-phosphate(in) + L-histidyl-[protein] => D-glucosamine(out) + N(pros)-phospho-L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2408524", "l": "Sec is reduced to H2Se by PXLP-K259-SCLY dimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5218828", "l": "PTK2/SRC-1 phosphorylates BCAR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004853", "l": "uroporphyrinogen decarboxylase activity", "d": ["Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-446877", "l": "TRAF6 is K63 poly-ubiquitinated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3928651", "l": "NGEF exchanges GTP for GDP on RHOA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39384", "l": "3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018766", "l": "RHOU binds effectors at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46720", "l": "(3R)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11787", "l": "H2O + L-aspartate + NADP(+) <=> H(+) + NADPH + NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034570", "l": "hydroxymonomethylisoproturon dimethylaminedehydrogenase activity", "d": ["Catalysis of the reaction: hydroxymonodemethylisoproturon + H2O = formaldehyde + 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617194", "l": "Phospho-STAT3 binds the promoter of the CEBPB gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672828", "l": "mTORC1 phosphorylates AKT1S1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797974", "l": "LRRTMs bind NRXNs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16700", "l": "A + H2O + quinaldate <=> AH2 + kynurenate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25372", "l": "(2S)-2-amino-4-deoxychorismate + FMN => 3-(1-carboxyvinyloxy)anthranilate + FMNH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51094", "l": "10,11-epoxy-(4Z,7Z,13Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36601", "l": "NADH + sulfur => hydrogen sulfide + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8953115", "l": "E2F6:TFDP1 binds to MGA:MAX (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68009", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (2E,6E,10E)-geranylgeranyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.71", "l": "\"endothelin-converting enzyme 1\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28710", "l": "Cd(2+)(in) <=> Cd(2+)(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73996", "l": "geranylgeranyl diphosphate + H2O => (S)-(+)-nephthenol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43189", "l": "S-adenosyl-L-methionine + uridine(2634) in 25S rRNA => H(+) + N(3)-methyluridine(2634) in 25S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21445", "l": "3-(2-hydroxyphenyl)propanoate + NAD(+) => H(+) + NADH + trans-2-coumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23633", "l": "D-threo-isocitrate + NAD(+) => 2-oxoglutarate + CO2 + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9626928", "l": "CREBBP binds FOXO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68110", "l": "H(+) + keto-L-fructose + NADH => L-glucitol + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1247665", "l": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3- (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-880007", "l": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9834807", "l": "ILF3 binds PKR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27800", "l": "all-trans-octaprenyl diphosphate + 5 diphosphate => (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-399952", "l": "Phosphorylation of LIMK-1 by PAK (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198746", "l": "ERK1/2/5 activate RSK1/2/3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9011595", "l": "GSTZ1 dimer dehalogenates DCA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42254", "l": "3-oxoheptanoyl-[ACP] + CO2 + CoA => H(+) + malonyl-[ACP] + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015355", "l": "secondary active monocarboxylate transmembrane transporter activity", "d": ["Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57363", "l": "H2O + NADH <=> (6R)-NADHX", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28550", "l": "acetyl-CoA + anthranilate = CoA + N-acetylanthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11157", "l": "H2O + L-valine + NADP(+) => 3-methyl-2-oxobutanoate + H(+) + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54800", "l": "a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein] = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-histidyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70118", "l": "6-deoxo-28-norteasterone + O2 + reduced [NADPH--hemoprotein reductase] <=> 6alpha-hydroxy-28-norteasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13827", "l": "GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADH => GDP-alpha-D-rhamnose + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2993763", "l": "SENP1,2,5 proteolytically process SUMO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43217", "l": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine => (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-422104", "l": "Ghrelin O-acyltransferase octanoylates Proghrelin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8944247", "l": "Association of procollagen type VI (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482884", "l": "PE is hydrolyzed to 1-acyl LPE by PLA2[2] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62649", "l": "(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18077", "l": "L-arginyl-[dinitrogen reductase] + NAD(+) = H(+) + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide", "d": [], "t": []}, {"i": "EC:2.4.2.37", "l": "\"NAD(+)--dinitrogen-reductase ADP-D-ribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32248", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) => (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416559", "l": "Inactivation of Rho-GTP by p190RhoGAP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38519", "l": "1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O = (9Z)-octadecenoate + 2-octadecanoylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69762", "l": "H2O + NAD(+) + nonanal <=> 2 H(+) + NADH + nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15592", "l": "2-oxoglutarate + D-4-hydroxyphenylglycine <=> 4-hydroxyphenylglyoxylate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167419", "l": "The receptor:G-protein complex releases GDP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50743", "l": "H2O + leukotriene C4 <=> glycine + leukotriene F4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58576", "l": "dihydroprecondylocarpine acetate + NADP(+) = H(+) + NADPH + precondylocarpine acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062059", "l": "FACT complex binding", "d": ["Binding to a FACT complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948143", "l": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2529015", "l": "Dephosphorylation of CK2-modified condensin I (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2046100", "l": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5694413", "l": "SEC4C,D bind GOSR2 and STX5 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58553", "l": "15alpha-stemmadenine intermediate II + H2O => (16R)-deshydroxymethyl-stemmadenine + formate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55465", "l": "11-hydroxysugiol + O2 + reduced [NADPH--hemoprotein reductase] => 11,20-dihydroxysugiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047992", "l": "hydroxylysine kinase activity", "d": ["Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031432", "l": "titin binding", "d": ["Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632386", "l": "TP63/TP53 stimulates transcription of DDIT4 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561041", "l": "OAT1-3 transport organic anions with antiport of dicarboxylic acids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68940", "l": "Cdt1 is displaced from the pre-replicative complex. (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9725885", "l": "P4 bind PGR (in the HSP90 chaperone complex) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-70560", "l": "carbamoyl phosphate + ornithine => citrulline + orthophosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788999", "l": "HV1-mediated H+ transfer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166119", "l": "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63117", "l": "peroxynitrite => nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654423", "l": "Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167085", "l": "Formation of DSIF:NELF:HIV-1 early elongation complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9677050", "l": "Formation of the GCN5-ATAC complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49520", "l": "2-oxoglutarate + an N(6)-methyladenosine in mRNA + O2 = an adenosine in mRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}, {"i": "EC:1.14.11.53", "l": "\"mRNA N(6)-methyladenine demethylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4088439", "l": "FOXM1 binds CENPF promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5362721", "l": "RDH5,RDH11 oxidise 11cROL to 11cRAL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13949", "l": "H(+) + NADP(+) + 2 reduced [rubredoxin] = NADPH + 2 oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034906", "l": "N-isopropylaniline 1,2-dixoxygenase activity", "d": ["Catalysis of the reaction: N-isopropylaniline + O2 + 2 H+ + NADH = catechol + NAD+ + isopropylamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-376851", "l": "SLC25A11 exchanges 2-OG and MAL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2972964", "l": "POU5F1 (OCT4), SOX2, NANOG bind the FOXD3 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56254", "l": "H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP => 3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9020257", "l": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.91", "l": "\"flavivirin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634884", "l": "NPAS4 binds CDK5 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-349426", "l": "Phosphorylation of MDM4 by CHEK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042926", "l": "3-hydroxyphenylpropionic acid transmembrane transporter activity", "d": ["Enables the directed movement of 3-hydroxyphenylpropionic acid from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78348", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58839", "l": "24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-111970", "l": "PKC phosphorylates GRK2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49556", "l": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) + L-cysteinyl-[protein] + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-159733", "l": "Furin cleaves pro-factor X to factor X (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37766", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193385", "l": "Hydrolysis of choloyl-CoA to cholate and CoASH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9656893", "l": "OPN1MW binds 11cRAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8856189", "l": "TNFSF8 binds TNFRSF8 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78536", "l": "N-acetyl-alpha-neuraminate(out) + 2 Na(+)(out) => N-acetyl-alpha-neuraminate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66250", "l": "AMP + H(+) + IC-asc-C9-CoA => CoA + IC-asc-C9-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26205", "l": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.n7", "l": "\"4-nitrophenol 2-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70903", "l": "urocanate + H2O => 4-imidazolone-5-propionate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.59", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-964958", "l": "2xPDXK:2xZn2+ phosphorylates PXA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55448", "l": "a 3',5'-unsubstituted flavanone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = a 3',5'-dihydroxyflavanone + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.81", "l": "\"flavonoid 3',5'-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0019117", "l": "dihydroxyfluorene dioxygenase activity", "d": ["Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9698170", "l": "Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75590", "l": "11-O-acetylcyathatriol + UDP-alpha-D-glucose <=> erinacine Q2 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983140", "l": "Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-445113", "l": "Urotensin-2 receptor binds urotensin-2 and 2B (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30510", "l": "2-demethylmenaquinone-8 + H(+) + NADH <=> 2-demethylmenaquinol-8 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46012", "l": "(S)-malate + a quinone = a quinol + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17613", "l": "NAD(+) + scyllo-inositol = H(+) + NADH + scyllo-inosose", "d": [], "t": []}, {"i": "EC:1.1.1.370", "l": "\"scyllo-inositol 2-dehydrogenase (NAD(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50674", "l": "[(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose => [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-446684", "l": "IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36836", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25957", "l": "2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) => 3-dehydroquinate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638007", "l": "RP2 activates the GTPase activity of ARL3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112149", "l": "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4419979", "l": "SRD5A3 reduces pPNOL to DCHOL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830461", "l": "PAX2 binds the EMX2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38284", "l": "itaconate + succinyl-CoA => itaconyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-446201", "l": "PMM1,2 isomerise Man6P to Man1P (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49970", "l": "17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75099", "l": "(4Z,15Z)-bilirubin IXalpha + UDP-alpha-D-glucuronate = (4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4085217", "l": "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046096", "l": "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48549", "l": "[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O => [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-202137", "l": "AKT1 binds eNOS complex via HSP90 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58968", "l": "1-naphthaldehyde + H2O + O2 = 1-naphthoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9755937", "l": "DHCR24 reduces LAN to 24,25-dhLAN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0008417", "l": "fucosyltransferase activity", "d": ["Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54105", "l": "N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine => H(+) + N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77068", "l": "Activation of GT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9619376", "l": "CAMK1 binds calmodulin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-196060", "l": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17868", "l": "5,6,7,8-tetrahydropteridine + NADP(+) <=> 6,7-dihydropteridine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390251", "l": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20916", "l": "L-cysteine + sulfite = hydrogen sulfide + L-cysteate", "d": [], "t": []}, {"i": "EC:4.4.1.10", "l": "\"cysteine lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40351", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2213201", "l": "Formation of collagen fibres (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-203611", "l": "N-myristoylation of eNOS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.120", "l": "\"galactose 1-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12955", "l": "ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein] => ATP + L-seryl-[Goodpasture antigen-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38812", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine => 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0045145", "l": "single-stranded DNA 5'-3' DNA exonuclease activity", "d": ["Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule."], "t": []}, {"i": "EC:3.1.11.4", "l": "\"exodeoxyribonuclease (phage SP3-induced)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1592240", "l": "Formation of NRF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42321", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-983144", "l": "Transport of Antigen peptide in to ER (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77366", "l": "2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine <=> 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015180", "l": "L-alanine transmembrane transporter activity", "d": ["Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9619355", "l": "CaMKK autophosphorylates in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467811", "l": "Separation of sister chromatids (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5662466", "l": "XYLB phosphorylates D-xylulose (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3266557", "l": "Factor I cleaves iC3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1454791", "l": "MMP2, MMP7, MMP9 bind CD44 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55986", "l": "(R)-prunasin + H(+) + UDP => (R)-mandelonitrile + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35799", "l": "7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3777112", "l": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8875871", "l": "SLC26A11 transports SO4(2-) from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64088", "l": "acetyl-CoA + 9 H(+) + holo-[ACP] + 9 malonyl-CoA = 3-(2,4-dioxopentyl)-3,6,8,9-tetrahydroxy-1-oxo-1,2,3,4-tetrahydroanthracene-2-carboxyl-[ACP] + 9 CO2 + 10 CoA + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855062", "l": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111915", "l": "CAMK4 autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41338", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate => (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65193", "l": "2 2-oxoglutarate + 2 O2 + preaustinoid A => berkeleytrione + 2 CO2 + H2O + 2 succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.16.8.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-73798", "l": "AICAR + 10-Formyl-THF => FAICAR + THF (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4568740", "l": "AP-1 stimulates IL1A transcription (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654511", "l": "FGFRL1 dimer binds FGFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15951", "l": "2-oxooctadecanoate + H(+) + NADH => (R)-2-hydroxyoctadecanoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018612", "l": "dibenzothiophene dioxygenase activity", "d": ["Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9796617", "l": "MIB2 binds CFLAR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9026780", "l": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9748957", "l": "GMPS dimer transforms 6TXMP to 6TGMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22153", "l": "a ubiquinone + D-glucose => a ubiquinol + D-glucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34513", "l": "H(+) + N-acetyl-alpha-D-galactosaminyl-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP => N,N'-diacetyl-alpha-D-bacillosaminyl-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69211", "l": "(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ATP + L-glutamate <=> (L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[tubulin] + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55130", "l": "(2E)-5-methylhexenoyl-[ACP] + H2O => (3R)-hydroxy-5-methylhexanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64962", "l": "dTMP + H(+) + phosphate => dTDP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71333", "l": "chloride(in) + L-phenylalanine(in) + 2 Na(+)(in) => chloride(out) + L-phenylalanine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57545", "l": "(S)-beta-macrocarpene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] + zealexin A1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12080", "l": "acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.180", "l": "\"beta-ketoacyl-[acyl-carrier-protein] synthase III\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5226904", "l": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424487", "l": "Phosphorylation of PLC-gamma by p-BTK/p-SYK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74112", "l": "H(+) + hypotaurine + NADH + O2 => H2O + NAD(+) + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71839", "l": "dehydroepiandrosterone 3-sulfate(out) = dehydroepiandrosterone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177938", "l": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674531", "l": "AAMP binds EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785607", "l": "FANCM binds FAAP24 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130731", "l": "Formation of COPII vesicle (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37081", "l": "2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + H(+) + S-adenosyl-L-homocysteine => 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8879123", "l": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36058", "l": "a 2-amino-4-hydroxypteridine + H(+) + H2O <=> a 2,4-dihydroxypteridine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0015140", "l": "malate transmembrane transporter activity", "d": ["Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22969", "l": "butanal + CoA + NAD(+) => butanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33714", "l": "4-sulfomuconolactone + H2O <=> 2 H(+) + maleylacetate + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6800279", "l": "TP53 binds the PIDD1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47764", "l": "S-adenosyl-L-methionine + uridine(1369) in 16S rRNA = 2'-O-methyluridine(1369) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29618", "l": "alpha-maltotriose + beta-maltose <=> alpha-maltotetraose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71964", "l": "(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) => (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33077", "l": "6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine => 3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32069", "l": "NH4(+) + urate => 8-oxoguanine + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665416", "l": "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046084", "l": "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856157", "l": "LAG3 (CD233) binds MHC II (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77522", "l": "furfural + hydrogen cyanide <=> (2R)-2-(furan-2-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047206", "l": "UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA(Ala) = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA(Ala)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5324617", "l": "HSP90:FKBP4:PTGES3 binds HSF1 trimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60192", "l": "2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + O2 = CO2 + formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2105001", "l": "HEXA cleaves the terminal GalNAc from DS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68593", "l": "(6S)-5,6,7,8-tetrahydrofolate(out) + ATP + H2O => (6S)-5,6,7,8-tetrahydrofolate(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106229", "l": "histone glutaryltransferase activity", "d": ["Catalysis of the reaction: glutaryl-CoA + histone = CoA + H+ + N6-glutaryl-histone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687360", "l": "POLL or POLM extends aligned DNA DSB ends to fill gaps (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5656070", "l": "FGFBPs bind FGFs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11928", "l": "hydroxylamine + NH4(+) = H(+) + H2O + hydrazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60286", "l": "H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine => N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22817", "l": "alpha-D-xylose => alpha-D-xylulofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32054", "l": "H2O + P(1),P(5)-bis(5'-adenosyl) pentaphosphate <=> adenosine 5'-tetraphosphate + AMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102820", "l": "norbixin methyltransferase activity", "d": ["Catalysis of the reaction: norbixin + S-adenosyl-L-methionine = bixin + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5652005", "l": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11593", "l": "dihydromonacolin L-[lovastatin nonaketide synthase] + H2O => dihydromonacolin L carboxylate + H(+) + holo-[lovastatin nonaketide synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73724", "l": "(S)-benzodiazepinedione + dimethylallyl diphosphate => (2R,3S,11S)-aszonalenin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54947", "l": "3-oxo-(5Z)-dodecenoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-(5Z)-dodecenoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30932", "l": "L-cysteine + O-acetyl-L-homoserine => acetate + H(+) + L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9609746", "l": "Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2B (GRIN2B) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23544", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.240", "l": "\"flavonol-3-O-glycoside glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102214", "l": "omega-hydroxy fatty acyl-CoA synthetase activity", "d": ["Catalysis of the reaction: coenzyme A + ATP + an omega-hydroxy fatty acid = diphosphoric acid + AMP + a omega-hydroxyacyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265424", "l": "SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-183002", "l": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174121", "l": "Association of Securin with Cdc20:APC/C complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46445", "l": "(11Z)-hexadecenoyl-CoA + AH2 + O2 => (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53632", "l": "(2E,6E)-farnesyl diphosphate = (3S)-(+)-asterisca-2(9),6-diene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.161", "l": "\"(3S)-(+)-asterisca-2(9),6-diene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47546", "l": "cis-4-hydroxy-D-proline betaine => trans-4-hydroxy-L-proline betaine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.674113164858127", "identifiers": [{"i": "GO:0016822", "l": "hydrolase activity, acting on acid carbon-carbon bonds", "d": ["Catalysis of the hydrolysis of any acid carbon-carbon bond."], "t": []}, {"i": "EC:3.7.-.-", "l": "\"Acting on carbon-carbon bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48165", "l": "epoxypheophorbide a + H2O => H(+) + red chlorophyll catabolite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10115", "l": "L-homocysteine + L-serine <=> H2O + L,L-cystathionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2559568", "l": "SARM binds TICAM1:TRAM:TLR4:LY96:LPS:CD14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-72231", "l": "Formation of the Cleavage and Polyadenylation Complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77099", "l": "5-hydroxymethyl-dUMP + H2O = 2-deoxy-D-ribose 5-phosphate + 5-hydroxymethyluracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33258", "l": "2-demethylmenaquinol-7 + S-adenosyl-L-methionine <=> H(+) + menaquinol-7 + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170076", "l": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75866", "l": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18242", "l": "D-lysine => (2R,5S)-2,5-diaminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.53", "l": "\"lytic chitin monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34851", "l": "(3S)-3-hydroxyadipyl-CoA + NAD(+) = 3-oxoadipyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43243", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H2O <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1236955", "l": "Movement of clathrin coated vesicles into early endosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5082356", "l": "HSF1-mediated gene expression (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-445079", "l": "Phosphorylation of L1 by ERK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0047291", "l": "lactosylceramide alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52270", "l": "(1H-indol-3-yl)-N-methylmethanamine + H(+) + S-adenosyl-L-homocysteine => 3-(aminomethyl)indole + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852130", "l": "UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35029", "l": "ADP + H(+) + phosphate + tungstate(out) => ATP + H2O + tungstate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20258", "l": "3-methyloxindole + NADP(+) => 3-methyleneoxindole + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56280", "l": "3'-L-prolyl-AMP + holo-[peptidyl-carrier protein] = AMP + L-prolyl-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28051", "l": "H2O + NADP(+) => NAD(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17401", "l": "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.83", "l": "\"4-oxalmesaconate hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8878914", "l": "B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050107", "l": "monoterpenol O-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51267", "l": "4'-O-methylnorbelladine + O2 + reduced [NADPH--hemoprotein reductase] <=> (10bS,4aR)-noroxomaritidine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047602", "l": "acetoacetate decarboxylase activity", "d": ["Catalysis of the reaction: acetoacetate + H+ = acetone + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42654", "l": "diphthine methyl ester-[translation elongation factor 2] + 3 H(+) + 4 S-adenosyl-L-homocysteine => 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67748", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828727", "l": "N mRNA is translated into protein N (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870269", "l": "Gastrin binds to CCK-B receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54879", "l": "(4S,7S)-7-hydroxy-4-isopropenyl-7-methyloxepan-2-one <=> (3S)-3-isopropenyl-6-oxoheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40026", "l": "9alpha-copalyl diphosphate + H2O <=> diphosphate + syn-copalol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0051735", "l": "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity", "d": ["Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76295", "l": "cob(I)alamin + S-adenosyl-L-methionine = methylcob(III)alamin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33761", "l": "a 3-hydroxy-fatty acyl-CoA + NADP(+) => a 3-oxo-fatty acyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38510", "l": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O <=> 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509816", "l": "NUDT16 hydrolyses IDP to IMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46766", "l": "a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213236", "l": "TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913675", "l": "GALNTs transfer GalNAc to Mucins to form Tn antigens (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76092", "l": "(11R)-19-hydroxycarlactone + O2 + reduced [NADPH--hemoprotein reductase] => (11R)-19-oxocarlactone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5669013", "l": "EDA-3 binds EDA2R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35651", "l": "(4R)-hydroxysphinganine + a fatty acyl-CoA = an N-acyl-(4R)-4-hydroxysphinganine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102557", "l": "protopanaxadiol 6-hydroxylase activity", "d": ["Catalysis of the reaction: (20S)-protopanaxadiol + O2 + NADPH(4-) + H+ = protopanaxatriol + NADP + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75244", "l": "FASL binds FAS Receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56153", "l": "(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine => (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74945", "l": "a (3R)-3-isocyanyl-fatty acid + 2 CO2 + 2 H2O + succinate => 2-oxoglutarate + a (3R)-3-{[carboxy(hydroxy)methyl]amino}fatty acid + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428917", "l": "G13 activation by TP receptor (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036381", "l": "pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191322", "l": "FDPS dimer transfers IPPP to DMAPP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070280", "l": "pyridoxal binding", "d": ["Binding to pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9727347", "l": "XDH dehydrogenates hypoxanthine to form xanthine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58231", "l": "L-asparaginyl-[protein] + NAD(+) <=> H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5634100", "l": "FABP5 dissociates from RXRA:PPARD:atRA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52470", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + H(+) + UDP => 16alpha,17beta-estriol + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8982163", "l": "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6811428", "l": "RIC1:RGP1 recruits RAB6:GDP to the TGN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018630", "l": "3,5-xylenol methylhydroxylase activity", "d": ["Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5668404", "l": "TNFA binds TNFR2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60925", "l": "2-oxoglutarate + N(6)-methyl-L-lysyl-[protein] + O2 => CO2 + formaldehyde + L-lysyl-[protein] + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56878", "l": "(R)-1-phenylethylamine + acetate => (R)-N-acetyl-1-phenylethylamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73283", "l": "H(+)(out) + L-isoleucine(in) = H(+)(in) + L-isoleucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977359", "l": "Complement factor I binds to membrane-associated Factor H:C3b (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948757", "l": "AKT phosphorylates MKRN1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9018785", "l": "RHOBTB2 binds GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25163", "l": "2-oxoglutarate + L-ornithine <=> L-glutamate + L-glutamate 5-semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.157", "l": "\"iota-carrageenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71233", "l": "2 Fe(2+)-[Dph3] + H(+) + NAD(+) => 2 Fe(3+)-[Dph3] + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23853", "l": "catechol + O2 => cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9627104", "l": "XIAP binds CASP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5656148", "l": "POLI incorporates dNMP opposite to damaged DNA base (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928640", "l": "PAKs phosphorylate MLC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65826", "l": "dec-9-ynoyl-[ACP] + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => dec-9-enoyl-[ACP] + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388560", "l": "EDNRA,EDNRB bind EDNs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5672817", "l": "Active MTORC1 binds the ULK1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66832", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate = diphosphate + preasperterpenoid A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30885", "l": "D-glucarate + 3 H(+) + NADH => D-glucurono-3,6-lactone + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64971", "l": "dUTP + H2O <=> dUDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50585", "l": "13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) => 15-oxoprostaglandin E1 + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35341", "l": "3-oxoeicosanoyl-CoA + H(+) + NADPH => 3-hydroxyicosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70454", "l": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40503", "l": "N-[omega-(9R)-hydroperoxy-(10E,12Z)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine = N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecadienoyloxy]acyl-beta-D-glucosyl-(1<->1)-octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33401", "l": "L-histidyl-[protein] + N-acetyl-beta-D-muramate 6-phosphate(in) => N(pros)-phospho-L-histidyl-[protein] + N-acetyl-beta-D-muramate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9844057", "l": "SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73276", "l": "3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine => 4',7,8-trihydroxy-3'-methoxyflavone-7-olate + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13684", "l": "a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine <=> a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607737", "l": "BCL10 oligomerizes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033958", "l": "DNA-deoxyinosine glycosylase activity", "d": ["Catalysis of the hydrolysis of DNA and polynucleotides, releasing free hypoxanthine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8942575", "l": "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211968", "l": "CYP2W1 oxidises INDOL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57803", "l": "2,3-dinitrotoluene + NADH + O2 <=> 4-methyl-3-nitrocatechol + H(+) + NAD(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61604", "l": "[DsbA protein]-dithiol + [DsbB protein]-disulfide = [DsbA protein]-disulfide + [DsbB protein]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811472", "l": "IER3 recruits MAPKs to PP2A-B56-beta,gamma (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-742354", "l": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37385", "l": "1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16014", "l": "ATP + glycine + tRNA(Gly) => AMP + diphosphate + glycyl-tRNA(Gly)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203553", "l": "eNOS binds NOSIP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2076383", "l": "HS3ST1 sulfates GlcN at C3 in heparan sulfate (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35323", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75732", "l": "(10S)-hydroxy-(12Z)-octadecenoate + NAD(+) => 10-oxo-(12Z)-octadecenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103116", "l": "ABC-type D-galactofuranose transporter", "d": ["Catalysis of the reaction: alpha-D-galactofuranose + ATP + H2O = alpha-D-galactofuranose + hydrogenphosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68399", "l": "a percarboxylic acid + H2O <=> a carboxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78926", "l": "a short-chain (3S)-3-hydroxyacyl-CoA + NAD(+) <=> a short-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1614591", "l": "Excess cysteine yields lanthionine and H2S (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3249390", "l": "TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5423637", "l": "AKR dimers reduce AFBDHO to AFBDOH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13147", "l": "alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine => 4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25822", "l": "4-aminobutanal + H2O2 + propane-1,3-diamine => H2O + O2 + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-913996", "l": "PKA/PKG phosphorylate Rap1GAP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1980125", "l": "ITCH binds DTX (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18302", "l": "ATP + NH4(+) + XMP => AMP + diphosphate + GMP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-399944", "l": "Phosphorylation of CRMPs by Cdk5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54908", "l": "(2E,4E)-hexadienoyl-CoA + H(+) + NADPH = (4E)-hexenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9759259", "l": "HSD11B2 dehydrogenates PREDL to PREDN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45848", "l": "(3R)-3-hydroxydodecanoyl-CoA + NADP(+) = 3-oxododecanoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901097", "l": "kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2] (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30880", "l": "H2O + NAD(+) + prop-2-ynal => 2 H(+) + NADH + propynoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73742", "l": "dopamine(in) + 2 H(+)(out) <=> dopamine(out) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72345", "l": "methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein] + resorcinol => 3-methoxyphenol + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176588", "l": "lithocholate + PAPS => lithocholate sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421471", "l": "hydroxymethylbilane => uroporphyrinogen I + H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2730856", "l": "Autophosphorylation of PAK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41956", "l": "2',3'-cyclophospho-CMP + H2O = cytidine 2'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57822", "l": "[phosphate](n+1) + AMP => [phosphate](n) + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8957265", "l": "26S proteasome degrades TP73 polyubiquitinated by ITCH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58724", "l": "adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77321", "l": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65156", "l": "2-oxoglutarate + O2 + preaustinoid A2 = CO2 + H2O + preaustinoid A3 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50626", "l": "a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+) => acetyl-CoA + an omega-(methylsulfanyl)-2-oxoalkanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15140", "l": "galactitol 1-phosphate + NAD(+) <=> H(+) + keto-L-tagatose 6-phosphate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-6810234", "l": "General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944227", "l": "Association of procollagen type XXII (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42084", "l": "9-cis-retinal + H2O + NAD(+) = 9-cis-retinoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102776", "l": "UDP-D-glucose:pelargonidin-3-O-beta-D-glucoside 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose = anthocyanidin 3,5-di-O-beta-D-glucoside + UDP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12318", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2562564", "l": "Caspase-8 processing within TLR4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22286", "l": "CO2 + NH4(+) + putrescine => 2 H(+) + H2O + N-carbamoylputrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74257", "l": "H(+) + L-homoserine + tRNA(Ser) => H2O + L-homoseryl-tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64357", "l": "2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 => (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2426156", "l": "SREBP1A,2 binds the PMVK promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9821475", "l": "CXXC1 and WDR82 bind SET1A complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57026", "l": "D-xylulose 5-phosphate + dihydroxyacetone phosphate => apulose 4-phosphate + D-glyceraldehyde 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8852131", "l": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018683", "l": "camphor 5-monooxygenase activity", "d": ["Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57860", "l": "(E)-6-hydroxyferuloyl-CoA = CoA + scopoletin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15803", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) => a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809777", "l": "PI3P is dephosphorylated to PI by MTMR2:SBF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9707856", "l": "PGRMC2:Hemes dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034738", "l": "lanosterol O-acyltransferase activity", "d": ["Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12828", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine <=> [thioredoxin]-dithiol + H(+) + phosphate + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49979", "l": "butanoyl-CoA + H2O <=> adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52244", "l": "4 H(+) + 4 Mn(2+) + O2 = 2 H2O + 4 Mn(3+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848370", "l": "IL18 binds IL18R1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46277", "l": "(S)-malate + H(+) => (S)-lactate + CO2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709454", "l": "EPOR binds EPOR agonists (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237129", "l": "Acireductone is created (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2671855", "l": "Phosphorylated LEPR Binds STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.96", "l": "\"carboxynorspermidine decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13772", "l": "glycerol + NAD(+) <=> dihydroxyacetone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65575", "l": "(-)-deoxypodophyllotoxin + O2 + reduced [NADPH--hemoprotein reductase] <=> (-)-4'-desmethyl-deoxypodophyllotoxin + formaldehyde + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9661405", "l": "ABCC1 transports BIL from cytosol to extracellular region (blood) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1234173", "l": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39288", "l": "Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + trimethylamine => dimethylamine + methyl-Co(III)-[trimethylamine-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "70.110299425343612", "identifiers": [{"i": "GO:0016763", "l": "pentosyltransferase activity", "d": ["Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49842", "l": "(-)-dehydrodiconiferyl acid carboxylate + 2 a quinol + H(+) => (-)-dehydrodiconiferyl acid + 2 a quinone + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18289", "l": "(S,S)-tartrate = H2O + oxaloacetate", "d": [], "t": []}, {"i": "EC:4.2.1.81", "l": "\"D(-)-tartrate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12981", "l": "H2O + O2 + S-sulfanylglutathione = glutathione + 2 H(+) + sulfite", "d": [], "t": []}, {"i": "EC:1.13.11.18", "l": "\"persulfide dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5218804", "l": "p38 MAPK activation by VEGFR (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40888", "l": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O => H(+) + octadecanoate + sn-glycerol 3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034864", "l": "2,4,4-trimethylpentanal dehydrogenase activity", "d": ["Catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27932", "l": "(R)-4'-phosphopantothenate + AMP + diphosphate + H(+) => (R)-4-phosphopantoate + ATP + beta-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13985", "l": "ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine", "d": [], "t": []}, {"i": "EC:2.7.1.39", "l": "\"homoserine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8949580", "l": "F1Fo ATP synthase dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1678708", "l": "SGSH hydrolyses Heparan sulfate chain(2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67359", "l": "(2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA <=> (2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16013", "l": "ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)", "d": [], "t": []}, {"i": "EC:6.1.1.14", "l": "\"glycine--tRNA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47526", "l": "7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADH => cholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374701", "l": "Phosphorylation of DCC by Fyn (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.5.10", "l": "\"NADPH dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49561", "l": "D-sedoheptulose 7-phosphate => (R)-demethyl-4-deoxygadusol + H(+) + H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46730", "l": "(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2 => (25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-264435", "l": "Dissociation of the COP1-p53 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904492", "l": "Ac-Asp-Glu binding", "d": ["Binding to Ac-Asp-Glu."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.375", "l": "\"rhamnogalacturonan I galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.76", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75194", "l": "2-dehydro-3-deoxy-L-fuconate + NAD(+) <=> 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389481", "l": "Orexin 1 receptor can bind orexin-A neuropeptide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42523", "l": "uridine(2605) in 23S rRNA <=> pseudouridine(2605) in 23S rRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-912527", "l": "SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9731931", "l": "EDNRA binds selective ERAs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428609", "l": "Type I Na+-coupled phosphate co-transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-391152", "l": "p-4Y-SIRPA:CD47 binds PTK2B (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78826", "l": "(3R)-5-guanidino-3-methyl-2-oxopentanoate + L-aspartate <=> (3R)-3-methyl-L-arginine + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37605", "l": "1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA => (11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649723", "l": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9825788", "l": "p-S207 KARS displaces HINT1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30709", "l": "4-aminobutanal + L-alanine => putrescine + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64679", "l": "3-(methylsulfanyl)propanoyl-CoA + butan-1-ol <=> butyl 3-(methylsulfanyl)propanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-418176", "l": "F2R:ARRB2 binds MAPKs, SRC-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71970", "l": "(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) <=> (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36022", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine <=> 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047931", "l": "glucosamine kinase activity", "d": ["Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53909", "l": "(2E)-butenoyl-CoA + L-lysyl-[protein] => CoA + H(+) + N(6)-(2E)-butenoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14752", "l": "1-hydroxy-2-naphthoate + O2 <=> (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24723", "l": "H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 => H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4754187", "l": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16208", "l": "H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] <=> N(6)-(D-fructosyl)-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5362448", "l": "Hh C-terminal fragments are degraded by the proteasome (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013006", "l": "RHOA:GTP translocates to the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9705794", "l": "SRD5A2 binds SRD5A2 inhibitors (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33354", "l": "hexacosanoyl-CoA + sphinganine <=> CoA + H(+) + N-hexacosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830969", "l": "EYA1, PAX2, and HOX11 paralog bind the GDNF gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3299691", "l": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.74", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-211206", "l": "Translocation of DFF to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27897", "l": "3'-CMP + H2O <=> cytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51025", "l": "H(+) + NADH + O2 + toluene-4-sulfonate => 4-(hydroxymethyl)benzenesulfonate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38956", "l": "an N-acylsphing-4-enine 1-phosphate(in) => an N-acylsphing-4-enine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-390256", "l": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48200", "l": "H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA = reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59487", "l": "arsenite + 2 Fe(III)-[cytochrome c] + H2O <=> arsenate + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35655", "l": "2 ATP = 3',3'-c-di-AMP + 2 diphosphate", "d": [], "t": []}, {"i": "EC:2.7.7.85", "l": "\"diadenylate cyclase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32769", "l": "2'-O-methylcytidine(4) in tRNA(Pro) + H(+) + S-adenosyl-L-homocysteine => cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-188371", "l": "Association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29232", "l": "cyanate(in) => cyanate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66529", "l": "ATP + O-(5'-adenylyl)-L-tyrosyl-[protein] => diphosphate + O-[5'-(adenylyl-(5'->3')-adenylyl)]-L-tyrosyl-[protein]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.335", "l": "\"4-amino-anhydrotetracycline N(4)-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48083", "l": "abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] <=> ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67507", "l": "1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13318", "l": "(2R,3R)-tartrate + H(+) => (R)-glycerate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62886", "l": "2 (M)-viriditoxin + 2 H2O => O2 + 4 semiviriditoxin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63190", "l": "A + H2O + norbelladine => 3,4-dihydroxybenzaldehyde + AH2 + tyramine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77615", "l": "Deamination at C6 position of adenosine in Editosome (ADAR2) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14163", "l": "3-(methylsulfanyl)propanoate + CO + formate + 2 H(+) => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34571", "l": "C30 botryococcene + diphosphate + NADP(+) = H(+) + NADPH + presqualene diphosphate", "d": [], "t": []}, {"i": "EC:1.3.1.97", "l": "\"botryococcene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1676124", "l": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78350", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2024084", "l": "HS-GAGs translocate to the lysosome for degradation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769397", "l": "SOST binds LRP5/6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-432065", "l": "p-S256-Aquaporin-2 passively transports water into cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008828", "l": "dATP diphosphatase activity", "d": ["Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-72691", "l": "Formation of the 43S pre-initiation complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008877", "l": "RUNX2:CBFB binds BGLAP gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-937044", "l": "Pellino binds hp-IRAK1:TRAF6 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0089702", "l": "undecaprenyl-phosphate glucose phosphotransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + ditrans,octacis-undecaprenyl phosphate = UMP + alpha-D-glucopyranosyl-diphospho-ditrans,octacis-undecaprenol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12461", "l": "(S)-malate => fumarate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27299", "l": "2-formylbenzoate + H2O + NAD(+) => 2 H(+) + NADH + phthalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3247840", "l": "WLS binds WNT ligands in the Golgi (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9027633", "l": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610754", "l": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5672012", "l": "Beclin-1 complex phosphorylates PtdIns (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44577", "l": "4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) => 2-all-trans-nonaprenylphenol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-380283", "l": "Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9648268", "l": "HTR1A binds HTR1A antagonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0017081", "l": "chloride channel regulator activity", "d": ["Binds to and modulates the activity of a chloride channel."], "t": []}, {"i": "REACT:R-HSA-383190", "l": "HCO3- transport through ion channel (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2995389", "l": "ANKLE2 binds VRK1,(VRK2) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37727", "l": "(9Z)-hexadecenoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45085", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67466", "l": "adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine => H2O + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10911", "l": "3'-phosphoadenylyl sulfate + glycolithocholate <=> adenosine 3',5'-bisphosphate + H(+) + sulfoglycolithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39499", "l": "(3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA = (2E,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73412", "l": "succinate(in) + sulfate(out) => succinate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14420", "l": "acetyl phosphate + L-lysine <=> H(+) + N(6)-acetyl-L-lysine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162078", "l": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9607301", "l": "Active FLT3:GRB2 binds SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56954", "l": "CDP + H(+) + phosphoenolpyruvate => CTP + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428690", "l": "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-373339", "l": "Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9692809", "l": "CDC42 binds effectors at the ER membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31958", "l": "9beta-pimara-7,15-diene + O2 + reduced [NADPH--hemoprotein reductase] <=> 9beta-pimara-7,15-dien-19-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1008200", "l": "NFE2 binds the beta globin locus control region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9732753", "l": "JAK1-activated RAF1 phosphorylates MAPKs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9761421", "l": "CDH11 associates with catenins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-433698", "l": "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75728", "l": "(10E,12Z)-octadecadienoate + H2O => (10S)-hydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76014", "l": "(3R)-hydroxybutanoate tetramer + H2O <=> (3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41599", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + H(+) + NADH <=> (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-170843", "l": "TGFBR2 phosphorylates TGFBR1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166753", "l": "Conversion of C4 into C4a and C4b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58386", "l": "H(+) + NADPH + octanal => NADP(+) + octan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033890", "l": "ribonuclease D activity", "d": ["Catalysis of the exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807106", "l": "PTEN undergoes monoubiquitination (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6790038", "l": "Expression of HSP90B1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6809263", "l": "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23264", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADP(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140293", "l": "ADP-ribosylglutamate hydrolase activity", "d": ["Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9693125", "l": "RHOF binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35901", "l": "1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA => 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990313", "l": "type-III cohesin domain binding", "d": ["Binding to a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9023626", "l": "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21624", "l": "FMNH2 + NADP(+) = FMN + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16247", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5697009", "l": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388596", "l": "Melanocortin receptors bind melanocortins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-174164", "l": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482775", "l": "MLCL is acylated to CL by HADH (IM) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33058", "l": "guanosine 3'-diphosphate 5'-triphosphate + H2O <=> diphosphate + GTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47137", "l": "ATP + CoA + lithocholate => AMP + diphosphate + lithocholoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374680", "l": "L1 trans-homophilic interaction (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72631", "l": "Formation of the cap-binding eIF4F complex (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42456", "l": "4alpha-methylzymosterol = zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5419264", "l": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5693977", "l": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102181", "l": "4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity", "d": ["Catalysis of the reaction: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 = 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1981104", "l": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2404199", "l": "IGF1,2:IGF1R autophosphorylates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75915", "l": "H2O + NAD(+) + serinol = dihydroxyacetone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75939", "l": "4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74202", "l": "aspulvinone E + O2 <=> (2Z)-2-[(3,4-dioxocyclohexa-1,5-dien-1-yl)methylidene]-4-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-olate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113402", "l": "Formation of DSIF:NELF:early elongation complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68907", "l": "3-phenylpropanoate + ATP + H(+) + NADPH <=> 3-phenylpropanal + AMP + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75806", "l": "butanoate(out) + Na(+)(out) <=> butanoate(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78062", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine <=> 2-(acylamino)ethyl fatty acid + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475017", "l": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24163", "l": "D-galactose + O2 <=> D-galacto-hexodialdose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004653", "l": "polypeptide N-acetylgalactosaminyltransferase activity", "d": ["Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73567", "l": "UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69863", "l": "a uridine in mRNA + S-adenosyl-L-methionine = a 5-methyluridine in mRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72048", "l": "A + D-alanine + D-allo-threonine + D-leucine + 2 L-leucine + L-proline => AH2 + fusahexin + 6 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70377", "l": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0099106", "l": "ion channel regulator activity", "d": ["Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52491", "l": "O2 + prostaglandin E2 + reduced [NADPH--hemoprotein reductase] <=> 20-hydroxy prostaglandin E2 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27971", "l": "D-maltotriose + H2O => alpha-D-glucose + D-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786070", "l": "IL4:IL4R:JAK2 binds IL13RA1:TYK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.1.125", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.88", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209371", "l": "LGS binds to ARM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5686074", "l": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-428259", "l": "DEGS1 dehydrogenates dihydroceramide (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-114552", "l": "Thrombin-activated PARs activate G12/13 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9857375", "l": "MITF dimerizes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.47", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25278", "l": "3',5'-cyclic AMP + H2O => AMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1247999", "l": "EGFRvIII mutant binds chaperone proteins HSP90 and CDC37. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17762", "l": "an aromatic primary alcohol + NADP(+) => an aromatic aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48351", "l": "a uridine in RNA <=> a pseudouridine in RNA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352191", "l": "SLC7A8-mediated uptake of neutral amino acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18642", "l": "a menaquinone + H2 => a menaquinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71671", "l": "glycyl-L-glutamine(out) + H(+)(out) = glycyl-L-glutamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45924", "l": "9-decenoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4-hydroxy-6-(2-oxoundec-10-en-1-yl)pyran-2-one + 3 CO2 + 4 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20810", "l": "CoA + N-acetyl-7-O-acetylneuraminate => acetyl-CoA + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392263", "l": "AVP(20-28) binds AVPR2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-444879", "l": "Relaxin receptor 2 binds relaxin 2 and INSL3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31374", "l": "(2R,3S)-2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine <=> (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29701", "l": "dimethyl sulfoxide(out) => dimethyl sulfoxide(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388829", "l": "SHP2 phosphatase binds CTLA-4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47326", "l": "3-oxo-3-phenylpropanoate + L-alanine => (S)-3-amino-3-phenylpropanoate + pyruvate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23102", "l": "ADP + dADP => ATP + dAMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199043", "l": "LILRs interact with MHC Class I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29216", "l": "fumarate + menaquinol-8 => menaquinone-8 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802911", "l": "High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.99.12", "l": "\"lachrymatory-factor synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9008412", "l": "CDK4 phosphorylates RUNX2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902122", "l": "chenodeoxycholic acid binding", "d": ["Binding to chenodeoxycholic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964317", "l": "PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15370", "l": "2,3-dihydroxybenzoate + O2 => 2-carboxy-cis,cis-muconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29360", "l": "H2O + UMP => phosphate + uridine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029466", "l": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75827", "l": "(5S)-hydroxy-(6E,8Z)-octadecadienoate + O2 + reduced [NADH--hemoprotein reductase] = (5S,18)-dihydroxy-(6E,8Z)-octadecadienoate + H(+) + H2O + oxidized [NADH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65670", "l": "a diacylglycerol + an N-(32-(9Z,12Z-octadecadienoyloxy)-dotriacontenoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(32-hydroxydotriacontenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60886", "l": "(N(7)-methyl 5'-triphospho-guanosine)-adenosine + a 5'-end phospho-ribonucleoside in mRNA + H(+) => a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine-phospho-ribonucleoside in mRNA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10187", "l": "(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O <=> 3-oxoadipate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31960", "l": "9beta-pimara-7,15-dien-19-ol + O2 + reduced [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-dien-19-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52105", "l": "a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate => an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60101", "l": "cyanidin + UDP-alpha-D-glucose => cyanidin 3-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54893", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide => [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3,5-bisthiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14921", "l": "(indol-3-yl)acetate + UDP-alpha-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.121", "l": "\"indole-3-acetate beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71833", "l": "chloride(in) + creatine(in) + 2 Na(+)(in) => chloride(out) + creatine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74849", "l": "3-diphospho-1D-myo-inositol 1,2,4,5-tetrakisphosphate + ADP => 1D-myo-inositol 1,2,3,4,5-pentakisphosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097383", "l": "dIDP phosphatase activity", "d": ["Catalysis of the reaction: dIDP + H2O = dIMP + H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5226979", "l": "ADD1:ADD2 binds DMTN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9690439", "l": "CYSLTR1 binds LTC4,LTD4,LTE4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853762", "l": "RET dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66745", "l": "ATP + H2O + N-acetyl-L-aspartate(in) => ADP + H(+) + N-acetyl-L-aspartate(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22267", "l": "3,5,6-trichloropyridin-2-ol + FADH2 + O2 <=> 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875838", "l": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77340", "l": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047863", "l": "dimethylallylcistransferase activity", "d": ["Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13917", "l": "(-)-menthol + NADP(+) = (1R,4S)-menthone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.207", "l": "\"(-)-menthol dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30484", "l": "N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-114354", "l": "SMAC binds XIAP:Caspase-7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24257", "l": "ATP + kanamycin A => ADP + H(+) + kanamycin 3'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9706364", "l": "Internalization of ubiquitinated FLT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56659", "l": "12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) <=> 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2028697", "l": "Cleavage of p-STK3 (p-MST2) by caspase 3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102290", "l": "beta-amyrin monooxygenase activity", "d": ["Catalysis of the reaction: beta-amyrin + O2 + NADPH + H+ = 11alpha-hydroxy-beta-amyrin + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63231", "l": "ATP + spectinomycin <=> 9-O-adenylylspectinomycin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3134946", "l": "DDX41 ubiquitination by TRIM21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57514", "l": "(1R,2R)-3-chlorocyclohexa-3,5-diene-1,2-diol + NAD(+) => chlorobenzene + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19636", "l": "(3S,5S)-3,5-diaminohexanoate + H2O + NAD(+) <=> (5S)-5-amino-3-oxohexanoate + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1237038", "l": "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64025", "l": "3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8),N'(8)-citryl-bis(spermidine) => H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8),N'(8)-citryl-bis(spermidine)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111289", "l": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5624492", "l": "PAK phosphorylates p21 RAF1 on S338 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55943", "l": "all-trans-3,4-didehydroretinol + NAD(+) <=> all-trans-3,4-didehydroretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75269", "l": "D-arabinono-1,5-lactone + H(+) + NADPH => D-arabinose + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51423", "l": "a (2S,3S)-flavan-3-ol + 2 NADP(+) <=> an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:1902249", "l": "IMP binding", "d": ["Binding to IMP, inosine monophosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17793", "l": "H2O + L-alanyl-tRNA(Thr) = H(+) + L-alanine + tRNA(Thr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65685", "l": "a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(36-hydroxyhexatriacontadienoyl)-sphing-4-enine => a diacylglycerol + an N-(36-(9Z,12Z-octadecadienoyloxy)-hexatriacontadienoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-203977", "l": "SAR1 Activation And Membrane Binding (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102591", "l": "delphinidin 7-O-glucoside acyltransferase (acyl-glucose dependent) activity", "d": ["Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-glucoside + 1-O-4-hydroxybenzoyl-beta-D-glucose = delphinidin 3-O-rutinoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22933", "l": "an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose => a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062054", "l": "fluoride channel activity", "d": ["Enables the energy-independent facilitated diffusion of a fluoride ion through a transmembrane aqueous pore or channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27795", "l": "(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate => all-trans-heptaprenyl diphosphate + 4 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391378", "l": "Follicle-stimulating hormone receptor can bind FSH (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14507", "l": "glutathione disulfide + 2 H(+) + hydrogen sulfide + sulfite => 2 glutathione + thiosulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675470", "l": "BIRC2/3 (cIAP1/2) is autoubiquitinated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43674", "l": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42304", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-428007", "l": "Proton-coupled histidine and di-peptide cotransport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15314", "l": "ethanolamine => acetaldehyde + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851298", "l": "GPR143 binds L-Dopa (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042880", "l": "D-glucuronate transmembrane transporter activity", "d": ["Enables the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41673", "l": "1-O-hexadecyl-sn-glycerol + ATP => 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694487", "l": "A4GNT transfers GlcNAc to core 2 mucins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21946", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + ADP + H(+) => ATP + D-cellobiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5138459", "l": "WNT5A:FZD4 is endocytosed (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000298", "l": "endopolyphosphatase activity", "d": ["Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18351", "l": "AMP + diphosphate + L-aspartyl-tRNA(Asx) => ATP + L-aspartate + tRNA(Asx)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70994", "l": "SDH complex dehydrogenates succinate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-141046", "l": "activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9714415", "l": "SLC6A4 binds TCAs and SSRIs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106282", "l": "isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: 3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD+ = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H+ + NADH."], "t": []}, {"i": "RHEA:42024", "l": "3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-196017", "l": "Dynamin is recruited to the gap junction plaque (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13233", "l": "guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34528", "l": "L-phenylalanine => (S)-3-amino-3-phenylpropanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69760", "l": "H2O + NAD(+) + nonanal => 2 H(+) + NADH + nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158164", "l": "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654167", "l": "Activated FGFR1 binds PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830356", "l": "Expression of LHX1 (LIM1) in the nephric duct (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693125", "l": "RHOF binds effectors at the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52777", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46749", "l": "carboxyphosphate + NH4(+) => carbamate + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24579", "l": "diphosphate + H2O <=> H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-69191", "l": "Formation of Cyclin E:Cdk2 complexes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007447", "l": "E2F6 forms the PRC1L4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005314", "l": "high-affinity L-glutamate transmembrane transporter activity", "d": ["Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40673", "l": "NH4(+) + pyruvate => 2-iminopropanoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17985", "l": "4-(trimethylamino)butanal + H2O + NAD(+) = 4-(trimethylamino)butanoate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.47", "l": "\"4-trimethylammoniobutyraldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2684901", "l": "ANOs transport cytosolic Cl- to extracellular region (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004865", "l": "protein serine/threonine phosphatase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2872498", "l": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21653", "l": "2-chlorobenzoate + H(+) + NADH + O2 => catechol + chloride + CO2 + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50127", "l": "NAD(+) + resolvin D1 <=> 8-oxoresolvin D1 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57385", "l": "(13S,14R)-1,13-dihydroxy-N-methylcanadine + acetyl-CoA => (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9664883", "l": "ATM:PEX5 translocates from cytosol to peroxisomal membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60169", "l": "a fatty acid + ATP => a fatty acyl phosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54917", "l": "9-cis-retinol + NADP(+) => 9-cis-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74621", "l": "CMP(out) + UMP(in) => CMP(in) + UMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13750", "l": "a ribonucleoside 5'-triphosphate + AMP => a ribonucleoside 5'-diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29714", "l": "cadaverine(in) + H(+)(in) <=> cadaverine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0016882", "l": "cyclo-ligase activity", "d": ["Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}, {"i": "EC:6.3.3.-", "l": "\"Cyclo-ligases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40171", "l": "dodecanoyl-CoA + O2 = (2E)-dodecenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9817282", "l": "DUX4 binds the LEUTX gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23656", "l": "2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H(+)", "d": [], "t": []}, {"i": "EC:5.5.1.2", "l": "\"3-carboxy-cis,cis-muconate cycloisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20821", "l": "choline sulfate + H2O => choline + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8874202", "l": "CREB3L3 translocates from the cytosol to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-198314", "l": "DAG stimulates protein kinase C-delta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65494", "l": "5'-deoxyadenosine + [mycofactocin precursor peptide]-C-terminal glycyl-N-{[2-(4-hydroxyphenyl)ethenyl]-3-methylbutanamide} + CO2 + L-methionine => [mycofactocin precursor peptide]-C-terminal glycyl-L-valyl-L-tyrosine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58221", "l": "L-lysyl-[protein] + NAD(+) => H(+) + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65421", "l": "GMP(in) + NAD(+)(out) => GMP(out) + NAD(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6807105", "l": "Monoubiquitinated PTEN translocates to the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5358340", "l": "Autoproteolytic cleavage of Hh precursors (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62490", "l": "2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + hexadecanoate => 1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57174", "l": "2-oxoglutarate + H(+) + NADH => (S)-2-hydroxyglutarate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72672", "l": "The 60S subunit joins the translation initiation complex  (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11227", "l": "ATP + 2 D-alanine <=> ADP + D-alanyl-D-alanine + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62498", "l": "diphosphate + L-arginyl-AMP => ATP + H(+) + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11240", "l": "ATP + thiamine diphosphate = ADP + thiamine triphosphate", "d": [], "t": []}, {"i": "EC:2.7.4.15", "l": "\"thiamine-diphosphate kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222128", "l": "NOC2L binds TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75629", "l": "ectocarpin D => (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15848", "l": "4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose <=> 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5601849", "l": "Defective CYP19A1 does not convert ANDST to E1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42513", "l": "5-acetamidopentanoate + H2O => 5-aminopentanoate + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-188467", "l": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665704", "l": "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50172", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-430073", "l": "GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41464", "l": "ent-sandaracopimara-8(14),15-diene + O2 + reduced [NADPH--hemoprotein reductase] = ent-sandaracopimaradien-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.70", "l": "\"ent-sandaracopimaradiene 3-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76511", "l": "5-deoxystrigol + H2O = 5-deoxystrigol ABC-rings + 5-hydroxy-3-methylfuran-2(5H)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79086", "l": "(3R)-3-methyl-D-ornithyl-N(6)-L-lysine + NAD(+) <=> 2 H(+) + L-pyrrolysine + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070908", "l": "tyrosine:tyramine antiporter activity", "d": ["Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37043", "l": "ATP + H2O + L-alanyl-L-glutamate(out) = ADP + H(+) + L-alanyl-L-glutamate(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2028675", "l": "Phosphorylation of MOB1A and B by p-STK3(MST2)/N (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33075", "l": "3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine", "d": [], "t": []}, {"i": "EC:2.5.1.120", "l": "\"aminodeoxyfutalosine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24797", "l": "(S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O = (S)-2-amino-6-oxoheptanedioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009018", "l": "sucrose phosphorylase activity", "d": ["Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62686", "l": "H(+) + rubrofusarin + S-adenosyl-L-homocysteine => norrubrofusarin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16571", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + CO2 + succinate => 2-oxoglutarate + L-lysyl-[collagen] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169210", "l": "PTP1B dephosphorylates JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15884", "l": "ATP + L-seryl-[Fas-activated protein] <=> ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5211387", "l": "Anthrax lef cleaves target cell MAP2K7 (MEK7) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21658", "l": "CDP-3,6-dideoxy-alpha-D-mannose => CDP-alpha-D-paratose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41026", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + octadecanoyl-CoA <=> 1-O-hexadecyl-2-acetyl-3-octadecanoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033427", "l": "CAA codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CAA codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12618", "l": "ATP + N-acetyl-alpha-D-galactosamine => ADP + H(+) + N-acetyl-alpha-D-galactosamine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448660", "l": "IL31:IL31RA:JAK1 binds OSMR:JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1268022", "l": "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70670", "l": "PRODH oxidises L-Pro to 1PYR-5COOH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22832", "l": "H2O + N-formimidoyl-L-glutamate = N-formyl-L-glutamate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.3.13", "l": "\"formimidoylglutamate deiminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0120014", "l": "phospholipid transfer activity", "d": ["Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76348", "l": "(2R,3S)-3-isopropylmalate(in) + sulfate(out) => (2R,3S)-3-isopropylmalate(out) + sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64750", "l": "2-methyl-3-sulfanylbutan-1-ol + NH4(+) + pyruvate => H2O + S-(4-hydroxy-3-methylbutan-2-yl)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60308", "l": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.357", "l": "\"[histone H3]-lysine(36) N-dimethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34370", "l": "acrylamide + H2O <=> acrylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70610", "l": "3'-phosphoadenylyl sulfate + 4-ethylphenol <=> 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111264", "l": "Addition of nucleotides between position +11 and +30 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31275", "l": "(S)-3-hydroxy-2-methylpropanoate + NAD(+) = (S)-2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008706", "l": "6-phospho-beta-glucosidase activity", "d": ["Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8941628", "l": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9731111", "l": "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56812", "l": "2-oxoglutarate + chloride + H(+) + L-threonyl-[peptidyl-carrier protein] + O2 = 4-chloro-L-threonyl-[peptidyl-carrier protein] + CO2 + H2O + succinate", "d": [], "t": []}, {"i": "EC:1.14.20.15", "l": "\"L-threonyl-[L-threonyl-carrier protein] 4-chlorinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761452", "l": "CTNNA1 binds to CDH11-bound CTNNB1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42863", "l": "1,2-dioctanoyl-sn-glycero-3-phosphate + H2O <=> 1,2-dioctanoyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9691168", "l": "RAC1 translocates to the endoplasmic reticulum membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29352", "l": "Zn(2+)(in) => Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31160", "l": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) => 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8952996", "l": "E2F7 forms homodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1605717", "l": "GM2A binds and mobilizes ligands (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39152", "l": "3-oxooctadecanoyl-CoA + H(+) + NADPH => (3R)-hydroxyoctadecanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.64", "l": "\"retinoid isomerohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033855", "l": "nicotianamine aminotransferase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-983218", "l": "RAD51B:RAD51C binds single-stranded DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51420", "l": "a (2S,3S)-flavan-3-ol + 2 NADP(+) = an anthocyanidin with a 3-hydroxy group + 2 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72639", "l": "1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine = 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70633", "l": "2''-O-decanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide => H2O + N(6)-decanoyl-L-lysyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592371", "l": "Initial activation of proMMP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12101", "l": "1,5-anhydro-D-fructose => H2O + microthecin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3225851", "l": "ROS oxidize thioredoxin and activate MAP3K5 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-266051", "l": "5S-HpETE is dehydrated to LTA4 by ALOX5 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61118", "l": "(2R,3R)-dihydromyricetin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (2R,3R)-dihydroquercetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9693478", "l": "HTR1A binds HTR1A agonists (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74220", "l": "H2O + L-seryl-tRNA(Thr) => L-serine + tRNA(Thr)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0032052", "l": "bile acid binding", "d": ["Binding to a bile acid, a steroid carboxylic acids occurring in bile."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39848", "l": "a 2-acylglycerol + ATP => a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045302", "l": "choloylglycine hydrolase activity", "d": ["Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78030", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycerol <=> a 1-acyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53531", "l": "1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine <=> 1,2-diheptadecanoyl-sn-glycero-3-phospho-N-(9Z-octadecenoyl)-ethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877311", "l": "RAB31 GEFs exchange GTP for GDP on RAB31 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31639", "l": "mycinamicin III + S-adenosyl-L-methionine = H(+) + mycinamicin IV + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.237", "l": "\"mycinamicin III 3''-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42709", "l": "guanosine(46) in tRNA + S-adenosyl-L-methionine => N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61204", "l": "L-arginyl-[protein] + L-cysteinyl-[protein] + methylglyoxal = H(+) + 2 H2O + N(5)-[4-(S-L-cysteinyl-[protein])-5-methyl-1H-imidazol-2-yl]-L-ornithinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9620103", "l": "ALDH2 transforms GTN to NO (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.3.24", "l": "\"malyl-CoA lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48048", "l": "a ganglioside GM1 (d18:1(4E)) + H2O = a ganglioside GM2 (d18:1(4E)) + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654643", "l": "Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32292", "l": "phosphoethanolamine + 3 S-adenosyl-L-methionine => 3 H(+) + phosphocholine + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40609", "l": "glycerol + H(+) + tetradecanoate => 1-tetradecanoyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77457", "l": "(2R)-2-hydroxy-2-(thiophen-2-yl)acetonitrile => formylthiophene + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52208", "l": "alachlor + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = H2O + methyl formate + N-(2,6-diethylphenyl)-2-chloroacetamide + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76756", "l": "decan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] => 1,3-decanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21231", "l": "alpha-maltose <=> beta-maltose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74098", "l": "ADP-L-glycero-beta-D-manno-heptose + an L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A <=> ADP + an L-alpha-D-Hep-(1->7)-L-alpha-D-Hep-(1->3)-4-O-phospho-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2128994", "l": "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70475", "l": "GPI dimer isomerizes Fru(6)P to G6P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050618", "l": "phycoerythrobilin:ferredoxin oxidoreductase activity", "d": ["Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-171122", "l": "LDL + LDLR => LDL:LDLR complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.11.2", "l": "\"membrane alanyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710294", "l": "GSDMD expression mediated by IRF2, IRF1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18038", "l": "agmatine + H2O => N-carbamoylputrescine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353484", "l": "Uracil glycosylase mediated recognition and binding of uracil opposite guanine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874208", "l": "CREB3L3 translocates from the endoplasmic reticulum membrane to the Golgi membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20540", "l": "H2O + holo-[ACP] <=> (R)-4'-phosphopantetheine + apo-[ACP] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2065549", "l": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5250209", "l": "ARL2:GTP:ARL2BP binds SLC25A4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9033514", "l": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2534378", "l": "Hv1 Mediated H+ Permeability (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "75.51128060092941", "identifiers": [{"i": "GO:0019901", "l": "protein kinase binding", "d": ["Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-77329", "l": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39751", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-417829", "l": "P2RY12 binds ADP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0003854", "l": "3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H+. Also acts on on 3-beta-hydroxypregn-5-en-20-one to form progesterone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8852128", "l": "UBA1 adenylates ubiquitin in the nucleoplasm (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65831", "l": "H2O + neryl diphosphate <=> diphosphate + nerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39142", "l": "(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA + H2O <=> (S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-210444", "l": "L-Glutamate loading of synaptic vesicle (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53587", "l": "NAD(+) + resolvin D2 <=> 7-oxoresolvin D2 + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9667563", "l": "AVPR2 bind desmopressin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67794", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-uridine-RNA => ribonucleotidyl-uridine-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17445", "l": "H2 + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.12.7.2", "l": "\"ferredoxin hydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3361751", "l": "beta-catenin is replaced by repression complexes at the promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1227775", "l": "TRAF6/or TRAF2 interacts with IPS-1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6791349", "l": "TP53 binds the APAF1 gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9824582", "l": "MAPK1 phosphorylates SOX10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45305", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O => 1,2-dihexadecanoyl-sn-glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58026", "l": "H(+) + oleanolate 3-O-beta-D-glucoside + UDP => oleanolate + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54446", "l": "a (2R,3R)-dihydroflavonol + H(+) + NADPH => a (2R,3S,4S)-leucoanthocyanidin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-112434", "l": "Formation of DSIF complex  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29686", "l": "alpha-maltohexaose + phosphate <=> alpha-D-glucose 1-phosphate + alpha-maltopentaose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77010", "l": "(2S)-5,5-dimethylpiperidine-2-carboxylate + 10-hydroxy-pre-flavunoidine + ATP <=> AMP + diphosphate + flavunoidine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8987042", "l": "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37349", "l": "ADP + D-alanyl-(R)-lactate + phosphate => (R)-lactate + ATP + D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.19", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49964", "l": "5,10-dihydrophenazine + O2 = H2O2 + phenazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192067", "l": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8853514", "l": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174657", "l": "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21628", "l": "17alpha-hydroxyprogesterone + NADPH + O2 = acetate + androst-4-ene-3,17-dione + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-110218", "l": "Cleavage of uracil by TDG glycosylase (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47055", "l": "(2E,6E)-farnesyl diphosphate <=> alpha-selinene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3132753", "l": "Pancreatic proteases degrade TCN1:RCbl (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9728723", "l": "Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48913", "l": "a ganglioside GD1a + CMP-N-acetyl-beta-neuraminate => a ganglioside GT1a + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5675373", "l": "Nuclear DUSPs dephosphorylate MAPKs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77158", "l": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O <=> 1D-myo-inositol 1,4,5-trisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3108209", "l": "PRC1 SUMOylates CTBP1 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37160", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3000310", "l": "AURKA phosphorylates PLK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6805730", "l": "SETD9 methylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6792445", "l": "LIPH, I hydrolyse PA to 2-acyl LPA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49638", "l": "H(+) + H2O2 + pyruvate => H2O + methylglyoxal + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162253", "l": "PDSS1,2 ligates FPP to IPPP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76632", "l": "Ca(2+)(in) + n H(+)(out) => Ca(2+)(out) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018707", "l": "1-phenanthrol methyltransferase activity", "d": ["Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928597", "l": "EPH:EFN dimers tetramerise (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696424", "l": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102323", "l": "2-isopropylphenol monooxygenase activity", "d": ["Catalysis of the reaction: 2-isopropylphenol + O2 + NADH + H+ = 3-isopropylcatechol + H2O + NAD."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71188", "l": "TDO tetramer dioxygenates L-Trp to NFK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664271", "l": "Release of PLCG from FCGR3A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12829", "l": "(2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.2", "l": "\"methylaspartate ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30279", "l": "2 H2 + NAD(+) + 2 oxidized [2Fe-2S]-[ferredoxin] = 3 H(+) + NADH + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.12.1.4", "l": "\"hydrogenase (NAD(+), ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9706390", "l": "RHOBTB3 binds interacting proteins at trans-Golgi network (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76543", "l": "N-acetyl-S-(2-succino)-L-cysteine = fumarate + N-acetyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694277", "l": "nsp8 generates RNA primers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.47", "l": "\"arabinofuranan 3-O-arabinosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0009884", "l": "cytokinin receptor activity", "d": ["Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8862090", "l": "PILRA binds PIANP, COLLEC12 trimer, NPDC1, CLEC4G (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-453338", "l": "PYGM b dimer:AMP complex <=> PYGM dimer, b form + 2 AMP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9012016", "l": "FAHD1 dimer hydrolyses OA to PYR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5623667", "l": "PDPK1 phosphorylates PKN1,2,3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10297", "l": "D-glyceraldehyde 3-phosphate + NADP(+) + phosphate => (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74028", "l": "L-alanine(in) + L-threonine(out) => L-alanine(out) + L-threonine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68644", "l": "(2E)-geranyl diphosphate = alpha-thujene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.41", "l": "\"sterol 24-C-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75220", "l": "H2O + L-fucono-1,5-lactone => H(+) + L-fuconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55504", "l": "(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] = (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.72", "l": "\"drimenol monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033479", "l": "Dimerization of FGFR2 point mutants with enhanced kinase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.116", "l": "\"glucan 1,4-alpha-maltotriohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9760082", "l": "NFE2L2 binds CREBBP,EP300 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607751", "l": "TRAF6 oligomerizes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2176475", "l": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177934", "l": "EGFR autophosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788650", "l": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71398", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate(out) <=> (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6802973", "l": "PLK3 phosphorylates CDC25C (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68067", "l": "a 14alpha-hydroxymethyl steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 14alpha-formyl steroid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602050", "l": "Defective CYP26C1 does not 4-hydroxylate 9cRA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8953037", "l": "E2F8 forms homodimers (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2130194", "l": "ABL phosphorylates WAVEs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48153", "l": "ganglioside GD1b(d18:1(4E)/18:0) + H2O => ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54031", "l": "a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] <=> a Delta(14) steroid + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956200", "l": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-159836", "l": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760128", "l": "AcK-NFE2L2-dependent GSTA1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-71200", "l": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41061", "l": "1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + CoA => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60309", "l": "L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine => 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48797", "l": "O2 + prostaglandin H1 + reduced [NADPH--hemoprotein reductase] => 19-hydroxyprostaglandin H1 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16456", "l": "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O <=> 2-formylbenzoate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31309", "l": "a dolichyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) => a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65136", "l": "(9Z)-octadecenoyl-CoA + 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine = 1-(10Z-heptadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9645428", "l": "ALPK1 binds ADP-heptose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19670", "l": "GTP + H2O => GDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928633", "l": "bPIX exchanges GTP for GDP on RAC, activating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-199803", "l": "xylulose 5-phosphate <=> D-ribulose 5-phosphate (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69041", "l": "(2S)-2-nitrosobutanedioate + H(+) + NADPH + O2 => 2-nitrobutanedioate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40641", "l": "(9Z,12Z)-octadecadienoate + a 1-acyl-sn-glycero-3-phosphoethanolamine + H(+) => 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851131", "l": "NPM1-ALK-stimulated PRF1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114259", "l": "Cleavage of Procaspase‑9 to caspase‑9 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9706298", "l": "Active FLT3 binds to CSK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45333", "l": "7,8-dihydroneopterin + O2 => 7,8-dihydroxanthopterin + formate + glycolaldehyde + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34895", "l": "ATP + H2O + selenite(out) = ADP + H(+) + phosphate + selenite(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3322995", "l": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60447", "l": "an S-substituted L-cysteinylglycine + H2O <=> an S-substituted L-cysteine + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60367", "l": "H(+)(out) + myo-inositol(out) <=> H(+)(in) + myo-inositol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607746", "l": "PKC-delta is activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37222", "l": "A + D-valine + H2O <=> 3-methyl-2-oxobutanoate + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193666", "l": "Active JNK moves to the nucleus and phosphorylates different transcription factors (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37628", "l": "(9Z)-octadecenoyl-CoA + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine => 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77455", "l": "formylthiophene + hydrogen cyanide = (2R)-2-hydroxy-2-(thiophen-2-yl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018756", "l": "RHOH binds GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6814831", "l": "TBC1D20 binds RAB1:GTP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58013", "l": "cyclic tetraadenylate => 2 5'-hydroxy-diadenylate 2',3'-cylic phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32732", "l": "a diacylglycerol + H2O => a fatty acid + a monoacylglycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-382553", "l": "ABCA7:Apo1A-mediated phospholipid efflux (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38827", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5694418", "l": "RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661121", "l": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66591", "l": "a cytidine in 26S rRNA + S-adenosyl-L-methionine <=> a 5-methylcytidine in 26S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202466", "l": "Interaction of Bcl10 to CARMA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40736", "l": "(20S)-ginsenoside Rb1 + 2 H2O => 2 D-glucose + gypenoside LXXV", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2984258", "l": "NEK9 phosphorylates NEK6/NEK7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2473596", "l": "Collagen type I degradation by MMP15 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167148", "l": "TFIIS-mediated recovery of elongation from arrest (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2454192", "l": "Allergen dependent IgE bound FCERI aggregation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72685", "l": "cholate(in) => cholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654664", "l": "Activated FGFR4:p-FRS binds GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63611", "l": "apelin-17 + H2O <=> apelin-16 + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22800", "l": "cycloeucalenol = obtusifoliol", "d": [], "t": []}, {"i": "EC:5.5.1.9", "l": "\"cycloeucalenol cycloisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54118", "l": "diphosphate + pseudolaratriene => (2E,6E,10E)-geranylgeranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27722", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4-formamido-beta-L-arabinose = 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP", "d": [], "t": []}, {"i": "EC:2.4.2.53", "l": "\"undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804276", "l": "ATM phosphorylates TTC5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38112", "l": "glycerol + NADP(+) => H(+) + L-glyceraldehyde + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1535903", "l": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9603302", "l": "Factor IIa inhibitors (peptide) binds IIa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-179410", "l": "Association of Nek2A with MCC:APC/C (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56579", "l": "a globoside Gb3Cer + UDP-N-acetyl-alpha-D-galactosamine <=> a globoside Gb4Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68671", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate <=> 16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47784", "l": "cytidine(3782) in 28S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(3782) in 28S rRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43554", "l": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate => 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67853", "l": "FMNH2 + O2 => FMN-N(5)-peroxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57846", "l": "H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form) => fraxetin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061863", "l": "microtubule plus end polymerase", "d": ["Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversible depending on the availability of dimers."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54383", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> 5-hydroxy-alpha-gurjunene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38718", "l": "ATP + choline(out) + H2O <=> ADP + choline(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71571", "l": "5-O-(L-seryl)-dTMP in DNA + H(+) = 5-aminoethoxy-methyl-dUMP in DNA + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5607746", "l": "PKC-delta is activated (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29222", "l": "a menaquinone + sn-glycerol 3-phosphate <=> a menaquinol + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374896", "l": "Uptake of Noradrenaline (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9853499", "l": "DLD dimer dehydrogenates dihydrolipoyl (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29873", "l": "ADP + H(+) + phosphate + thiosulfate(in) => ATP + H2O + thiosulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35505", "l": "30-hydroxy-11-oxo-beta-amyrin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 11-oxo-beta-amyrin + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48160", "l": "3 H(+) + O2 + pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] = epoxypheophorbide a + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6784729", "l": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033920", "l": "6-phospho-beta-galactosidase activity", "d": ["Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0043236", "l": "laminin binding", "d": ["Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44056", "l": "2-O-hexadecanoyl-alpha,alpha-trehalose + hexadecanoyl-CoA = 2-O,3-O-dihexadecanoyl-alpha,alpha-trehalose + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444527", "l": "FPR is a receptor for formyl peptides (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11832", "l": "(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) = H(+) + NADH + naphthalene-1,2-diol", "d": [], "t": []}, {"i": "EC:1.3.1.29", "l": "\"cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39127", "l": "(S)-3-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9007926", "l": "ATRX binds DAXX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5433067", "l": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28121", "l": "di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose <=> D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46490", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) => 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20798", "l": "D-ribulose => aldehydo-D-ribose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45222", "l": "Co(I)-[trimethylamine-specific corrinoid protein] + H(+) + methyl-coenzyme M => coenzyme M + methyl-Co(III)-[trimethylamine-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69492", "l": "O2 + octan-1-ol = H2O2 + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45364", "l": "H2O + N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine = (11Z)-eicosenoate + (4R)-hydroxysphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33462", "l": "H(+) + NADPH + zymosterone <=> NADP(+) + zymosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15276", "l": "2-oxoglutarate + L-dopa <=> 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65054", "l": "4-(trifluoromethyl)benzaldehyde + H(+) + NADH => 4-(trifluoromethyl)benzyl alcohol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-183084", "l": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5362386", "l": "Glycosylation of Hh (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18598", "l": "H(+) + NAD(+) + 2 reduced [rubredoxin] => NADH + 2 oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051109", "l": "crotonobetaine-CoA ligase activity", "d": ["Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15303", "l": "aldehydo-D-apiose + H(+) + NADH => D-apiitol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10828", "l": "anthranilate + ATP + CoA = AMP + anthraniloyl-CoA + diphosphate", "d": [], "t": []}, {"i": "EC:6.2.1.32", "l": "\"anthranilate--CoA ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24041", "l": "NADPH + 2 oxidized [cytochrome P450] => H(+) + NADP(+) + 2 reduced [cytochrome P450]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56447", "l": "1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O <=> 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5683986", "l": "APBB1 and MAPK8 bind diphosphorylated H2AFX (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004920", "l": "interleukin-10 receptor activity", "d": ["Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46824", "l": "4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 = 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9853385", "l": "PPP1CC dephosphorylates PLK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-69006", "l": "Phosphorylated Cdc6 is exported from the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73585", "l": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44191", "l": "(9Z)-hexadecenoyl-CoA + sn-glycerol 3-phosphate <=> 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2213201", "l": "Formation of collagen fibres (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65332", "l": "H(+) + NADPH + O2 + verruculide A = chrodrimanin E + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9663492", "l": "BIL dissociates from GSTA1, FABP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9018746", "l": "RHOQ binds effectors at the plasma membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32888", "l": "all-trans-beta-carotene + O2 => 2 all-trans-retinal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1471338", "l": "Beta-defensins 1, 4A and 103 bind CCR6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-913370", "l": "Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5624131", "l": "UNC119B binds myristoylated proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23668", "l": "apo-[methylmalonyl-CoA:pyruvate carboxytransferase] + ATP + biotin = AMP + diphosphate + H(+) + holo-[methylmalonyl-CoA:pyruvate carboxytransferase]", "d": [], "t": []}, {"i": "EC:6.3.4.9", "l": "\"biotin--[methylmalonyl-CoA-carboxytransferase] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73632", "l": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-382096", "l": "Formation of NR-NCOR Corepressor Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045437", "l": "uridine nucleosidase activity", "d": ["Catalysis of the reaction: H2O + uridine = ribofuranose + uracil."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44612", "l": "3-(all-trans-decaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-decaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679205", "l": "ULK1 phosphorylates Beclin-1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29727", "l": "ethane-1-sulfonate + FMNH2 + O2 = acetaldehyde + FMN + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111915", "l": "CAMK4 autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052637", "l": "delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity", "d": ["Catalysis of the reaction: 1-18:3-3-16:0-phosphatidylglycerol = 1-18:3-3-trans-16:1-phosphatidylglycerol + 2 H+. This reaction is the formation of a trans double bond between carbon 3 and carbon 4 (counting from the carboxyl end) of palmitic acid, which is specifically esterified to the sn-2 glyceryl carbon of phosphatidylglycerol."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191636", "l": "Phosphorylation of Cx43 by c-src (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-429094", "l": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.1.75", "l": "\"poly(3-hydroxybutyrate) depolymerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-449058", "l": "Interleukin-1 family are secreted (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034905", "l": "5-chloro-4-hydroxy-2-oxopentanate aldolase activity", "d": ["Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200143", "l": "AKT phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75856", "l": "Abortive Initiation Before Second Transition (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57844", "l": "fraxetin + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + sideretin (reduced form)", "d": [], "t": []}, {"i": "EC:1.14.14.164", "l": "\"fraxetin 5-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028589", "l": "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55261", "l": "2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36355", "l": "4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.5.1.114", "l": "\"tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8954082", "l": "E2F6 binds the PRC1 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1605724", "l": "NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52557", "l": "3-dehydro-D-erythronate + ATP => 3-dehydro-4-O-phospho-D-erythronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672948", "l": "MARK3 phosphorylates KSR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72135", "l": "putrescine(out) = putrescine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48957", "l": "[thyroglobulin]-L-tyrosine + H(+) + H2O2 + iodide => [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427514", "l": "eNoSC deacetylates histone H3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5423632", "l": "AFXBO binds DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866851", "l": "CFTR transits to the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3858489", "l": "ppDVL binds DAAM1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60614", "l": "1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline => 1-octanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76103", "l": "(11R)-carlactonoate + S-adenosyl-L-methionine = (11R)-methyl carlactonoate + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32232", "l": "(6S)-NADPHX + ATP => ADP + H(+) + NADPH + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78260", "l": "D-proline + O2 => 1-pyrroline-2-carboxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25583", "l": "alpha-L-fucose <=> beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9679816", "l": "SIGMAR1 binds dextromethorphan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0099534", "l": "calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration", "d": ["The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687081", "l": "MAPK6 is ubiquitinated at the N-terminal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9817411", "l": "TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2584246", "l": "GNAT1-GTP hydrolyses its bound GTP to GDP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73918", "l": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2404193", "l": "IGF1R phosphorylates SHC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3858475", "l": "ppDVL recruits RAC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65094", "l": "aculene D + CO2 + 2 H2O + oxidized [NADPH--hemoprotein reductase] => asperaculane G + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.8.1.1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9693207", "l": "RHOD translocates to the mitochondrial outer membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-375342", "l": "Connexin 36 mediated neuronal gap junction communication (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014449", "l": "RHOG binds effectors at the plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012835", "l": "GDIs block activation of RHOA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4608855", "l": "PRICKLE1 is degraded by the proteasome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202407", "l": "PLC-gamma1 hydrolyses PIP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374173", "l": "AGT(34-41) binds to AGTR1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-997326", "l": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5662692", "l": "Dopa is oxidized to dopaquinone by TYR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042392", "l": "sphingosine-1-phosphate phosphatase activity", "d": ["Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.72", "l": "\"fibrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5653780", "l": "USP43 binds ISG:K164,ISG:K168-PCNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6807064", "l": "DHCR24 reduces ZYMOL to ZYMSTNL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682965", "l": "WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9837707", "l": "Release of hRSV A nucleocapsid from macropinosome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31533", "l": "CO2 + N(omega)-hydroxy-L-arginine + succinate => 2-oxoglutarate + L-arginine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66546", "l": "H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein] => L-cysteinyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18978", "l": "a quinone + sn-glycerol 3-phosphate => a quinol + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015626", "l": "L-diaminopimelate transmembrane transporter activity", "d": ["Enables the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9021609", "l": "ESR-associated SRC autophosphorylates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32961", "l": "(S)-3-methyl-2-oxopentanoate + H(+) + NADH + NH4(+) => H2O + L-isoleucine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69394", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+) => an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416516", "l": "GRK2 sequesters activated Gq (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-936564", "l": "NLRX1 inhibits MAVS-DDX58 interaction. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42844", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH = 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide", "d": [], "t": []}, {"i": "EC:2.3.1.240", "l": "\"narbonolide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70213", "l": "(S)-2-hydroxyglutarate + GDP-D-glycero-4-keto-alpha-D-lyxo-heptose => 2-oxoglutarate + GDP-D-glycero-alpha-D-manno-heptose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77959", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol = a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23754", "l": "ADP + all-trans-undecaprenyl phosphate + H(+) => all-trans-undecaprenol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36385", "l": "AMP + H(+) + nebramycin 5' => carbamoyl adenylate + tobramycin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937113", "l": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-388503", "l": "Oxytocin receptor bind oxytocin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50850", "l": "(11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75872", "l": "Conversion of malonyl-CoA and acetyl-CoA to palmitate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15116", "l": "5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O <=> 5alpha-cholestane-3beta,5,6beta-triol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22535", "l": "(2E)-octenedioyl-CoA + H2O <=> (3S)-hydroxyoctanedioyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832577", "l": "NS1:NS2 (1C:1B) localizes to mitochondria (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102257", "l": "1-16:0-2-18:2-phosphatidylcholine sn-1 acylhydrolase activity", "d": ["Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O = 1-linoleoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.50", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5653766", "l": "USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5657637", "l": "ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54581", "l": "a 5'-end dephospho-ribonucleoside-RNA + ATP => a 5'-end 5'-phospho-ribonucleoside-RNA + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5607758", "l": "CLEC7A binds 1,3-beta-D-glucan (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647982", "l": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9864415", "l": "AAC1 imports a proton (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12437", "l": "(E)-caffeoyl-CoA + putrescine => CoA + H(+) + N-caffeoylputrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34759", "l": "ATP + glycerol 2-phosphate(out) + H2O = ADP + glycerol 2-phosphate(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76449", "l": "ADP + H(+) + L-aspartyl-L-methionine + phosphate => ATP + L-aspartate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-927832", "l": "UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866851", "l": "CFTR transits to the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052769", "l": "beta-6-sulfate-N-acetylglucosaminidase activity", "d": ["Catalysis of the glycosidic cleavage of the terminal 2-acetamido-2-deoxy-beta-D-glucopyranoside 6-sulfate (6-SO3-GlcNAc) residue from sulfomucin, a sulfated mucin derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-141409", "l": "Mad1 binds kinetochore (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61443", "l": "acetyl-CoA + S-(2-succino)-L-cysteine <=> CoA + H(+) + N-acetyl-S-(2-succino)-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-622326", "l": "Activation of highly calcium permeable nicotinic acetylcholine receptors (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60099", "l": "4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) <=> 3-dehydro-4alpha-methylzymosterol + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42904", "l": "guanosine(748) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.188", "l": "\"23S rRNA (guanine(748)-N(1))-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75947", "l": "L-arginine + taurine = L-ornithine + taurocyamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832009", "l": "M2-1 tetramer gets phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3149494", "l": "MMACHC:cob(II)alamin binds MMADHC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28651", "l": "inosine + O2 = 9-riburonosylhypoxanthine + H(+) + H2O", "d": [], "t": []}, {"i": "EC:1.1.3.28", "l": "\"nucleoside oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30972", "l": "7,7',9,9'-tetra-cis-lycopene => all-trans-lycopene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990028", "l": "intermediate voltage-gated calcium channel activity", "d": ["Enables the transmembrane transfer of a calcium ion by an intermediate voltage-gated channel. An intermediate voltage-gated channel is a channel whose open state is dependent on intermediate voltage across the membrane in which it is embedded."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785636", "l": "Phosphorylated ERBB2 heterodimers bind MEMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-110250", "l": "Cleavage of ethenoadenine by MPG glycosylase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71701", "l": "H(+)(in) + L-phenylalanyl-L-leucine(in) => H(+)(out) + L-phenylalanyl-L-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.79", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46792", "l": "an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448603", "l": "IL33:IL1RL1 binds IL1RAP-1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6787321", "l": "DERA cleaves dR5P to GA3P and CH3CHO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.193", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-70994", "l": "SDH complex dehydrogenates succinate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5672951", "l": "Inactive RAFs bind YWHAB (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12466", "l": "alpha-D-galactosyl-(1->3)-1D-myo-inositol + H(+) + UDP => myo-inositol + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9759454", "l": "ABCB1 transports PREDN,PREDL out of kidney cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-981814", "l": "ST6GALNAC2 transfers sialic acid to Core 1 mucins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031839", "l": "type 1 neuromedin U receptor binding", "d": ["Binding to a type 1 neuromedin U receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13207", "l": "a UDP-monosaccharide + diphosphate => a monosaccharide 1-phosphate + H(+) + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5607733", "l": "BCL10 binds CARD9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32508", "l": "4-isopropenyl-7-methyloxepan-2-one + H2O => 6-hydroxy-3-isopropenylheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52444", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + GDP-alpha-D-mannose = 2-O-(alpha-D-mannosyl)-6-O-(6-O-acyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8874082", "l": "MET phosphorylates PTK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19472", "l": "NADH + 2 nitric oxide + 2 O2 <=> H(+) + NAD(+) + 2 nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78010", "l": "a 1,2-diacyl-3-(9Z,12Z-octadecadienoyl)-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine <=> a 1,2-diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9906955", "l": "MT-ND4 is translated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140701", "l": "3',3'-cyclic GMP-AMP synthase activity", "d": ["Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(3'-5') (cyclic 3',3' GAMP)."], "t": []}, {"i": "RHEA:35647", "l": "ATP + GTP = 3',3'-cGAMP + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48366", "l": "beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+) => beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30079", "l": "ATP + CoA + crotonobetaine = AMP + crotonobetainyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19230", "l": "AMP + an aromatic aldehyde + diphosphate + NADP(+) => an aromatic carboxylate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35316", "l": "H(+) + hexadecanoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161940", "l": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-917979", "l": "ABCG2 tetramer transports heme from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2162226", "l": "GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-174139", "l": "Dissociation of phospho-Cdh1 from the APC/C complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-435366", "l": "ZnT1 mediates the efflux of zinc from the cell (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24704", "l": "CO2 + NADH + UDP-beta-L-threo-pentopyranos-4-ulose => NAD(+) + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71214", "l": "chlorate(out) + 2 Na(+)(out) <=> chlorate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47171", "l": "4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) <=> 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1237119", "l": "Acireductone is oxidized to MOB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.188221489317044", "identifiers": [{"i": "GO:0019207", "l": "kinase regulator activity", "d": ["Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43123", "l": "2-oxoglutarate + O2 + xanthine <=> CO2 + succinate + urate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72383", "l": "Na(+)(out) + urate(in) = Na(+)(in) + urate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-187937", "l": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9693478", "l": "HTR1A binds HTR1A agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17687", "l": "CO2 + uracil => H(+) + uracil 5-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710959", "l": "p-STAT1 dimer binds KPNA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11076", "l": "anthranilate + 3 H(+) + NADH + O2 = catechol + CO2 + NAD(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39198", "l": "3-oxotetracosanoyl-CoA + H(+) + NADPH <=> (3R)-hydroxytetracosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52163", "l": "(E)-phenylacetaldehyde oxime <=> (Z)-phenylacetaldehyde oxime", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433395", "l": "Dimerization of sSCF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141090", "l": "protein serine pyrophosphorylase activity", "d": ["Catalysis of the reaction: protein phospho-serine + inositol 5-triphosphate pentakisphosphate = protein diphospho-serine + inositol 5-diphosphate pentakisphosphate."], "t": []}, {"i": "RHEA:64104", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + O-phospho-L-seryl-[protein] = 1D-myo-inositol hexakisphosphate + O-diphospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46870", "l": "a 2-acyl-sn-glycero-3-phosphocholine + lipid IVB (E. coli) => 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8857577", "l": "LINC01139 facilitates PTK6 autophosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9618378", "l": "POM121 binds the Nup107-Nup160 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57081", "l": "glutathione + S-methyl-1-thio-D-xylulose 5-phosphate => 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2473584", "l": "Collagen type III degradation by MMP15 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2316429", "l": "PIP3 recruits PDPK1 to the membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36671", "l": "(17Z)-hexacosenoyl-CoA + sphinganine = CoA + H(+) + N-[(17Z)-hexacosenoyl]dihydrosphingosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033426", "l": "CAC codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a CAC codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2997723", "l": "PIAS4 SUMOylates TP53BP1 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22679", "l": "chlorophyllide a + H(+) + NADPH + O2 <=> 7(1)-hydroxychlorophyllide a + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20313", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.158", "l": "\"inositol-pentakisphosphate 2-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78930", "l": "a very-long-chain (3S)-hydroxyacyl-CoA + NAD(+) <=> a very-long-chain 3-oxoacyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5674373", "l": "MAP2Ks phosphorylate MAPK at the Golgi membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49627", "l": "ATP + erythritol <=> ADP + D-erythritol 1-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69748", "l": "(indol-3-yl)acetate + succinyl-CoA => (indol-3-yl)acetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44150", "l": "D-beta-lysine => L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64166", "l": "formaldehyde + L-alanine => 2-methyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9603784", "l": "PEX19:class I PMP binds PEX3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9029561", "l": "NCOA1 recruits EP300 to the ABCA1 promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55531", "l": "H(+) + H2O + L-tyrosine + O2 <=> (4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71877", "l": "2 Na(+)(in) + taurocholate(in) => 2 Na(+)(out) + taurocholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033933", "l": "branched-dextran exo-1,2-alpha-glucosidase activity", "d": ["Catalysis of the hydrolysis of (1->2)-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3301943", "l": "GSTK1 dimer transfers GS from GSH to CDNB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201790", "l": "DARPP-32 is dephosphorylated on Thr75 by PP2A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8854908", "l": "PKA phosphorylates RET:GDNF:GFRA dimer (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050008", "l": "isopiperitenone delta-isomerase activity", "d": ["Catalysis of the reaction: isopiperitenone = piperitenone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50521", "l": "acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43613", "l": "S-adenosyl-L-methionine + uridine(341) in tmRNA => 5-methyluridine(341) in tmRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62556", "l": "3,4-dihydroxyphenylacetate + H(+) = 4-methylcatechol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3782637", "l": "HDAC8 deacetylates histones (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1169403", "l": "Interaction of E3 ligase with ISG15:E2 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1605595", "l": "bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15587", "l": "4 AH2 + all-trans-lycopene => 15-cis-phytoene + 4 A", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55844", "l": "calcidiol + UDP-alpha-D-glucuronate = calcidiol 3-O-(beta-D-glucuronide) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35207", "l": "H2O + IDP = H(+) + IMP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033881", "l": "bile-acid-CoA transferase activity", "d": ["Catalysis of the reaction: deoxycholoyl-CoA + cholate = deoxycholate + choloyl-CoA."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.119", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65615", "l": "a C21-steroid + O2 + reduced [NADPH--hemoprotein reductase] <=> a 21-hydroxy-C21-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9680443", "l": "ROCK1,2 bind ROCKi (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76410", "l": "H2O + Xaa-L-Pro dipeptide <=> an L-alpha-amino acid + L-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9020251", "l": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1793186", "l": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2395322", "l": "Formation of lysyl-pyridinoline cross-links (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914006", "l": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9022625", "l": "MECP2 binds FOXG1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52548", "l": "L-threonate + NAD(+) = 2-dehydro-L-erythronate + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.411", "l": "\"L-threonate 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-981728", "l": "Factor H binds to membrane-associated C3b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-190682", "l": "Connexin synthesis (generic) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-984648", "l": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74724", "l": "isorhamnetin + S-adenosyl-L-methionine => 3',4'-O-dimethylquercetin + 2 H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4551721", "l": "PIAS4 SUMOylates VHL with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22843", "l": "D-glutamine + H2O <=> D-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3928576", "l": "RHOA:GTP binds ROCK, activating it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9866104", "l": "Intermediate I binds second heme, UQCRB, UQCRQ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2203516", "l": "Alpha-1-Microglobulin is cleaved (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9700998", "l": "BAP1 disrupts the BRCA1:BARD1 heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42611", "l": "a plastoquinone + (n+1) H(+)(in) + NADH <=> a plastoquinol + n H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33437", "l": "episterol => fecosterol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75451", "l": "(9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9017491", "l": "RHOJ GEFs activate RHOJ (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64410", "l": "2 H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) => 2 H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53989", "l": "H2O + O-phospho-L-threonyl-[myosin light chain] => L-threonyl-[myosin light chain] + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32955", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18485", "l": "6-acetyl-D-glucose + H2O = acetate + D-glucose + H(+)", "d": [], "t": []}, {"i": "EC:3.1.1.33", "l": "\"6-acetylglucose deacetylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3928601", "l": "CDC42 and PIP2 bind WASL, activating it (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30688", "l": "(4R)-4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5683792", "l": "p-T68-CHEK2 autophosphorylates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004165", "l": "delta(3)-delta(2)-enoyl-CoA isomerase activity", "d": ["Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65660", "l": "A + calciol + H2O = AH2 + calcidiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69767", "l": "(E)-non-2-enal + H2O + NAD(+) = (E)-non-2-enoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21918", "l": "an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+) => an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005052", "l": "peroxisome matrix targeting signal-1 binding", "d": ["Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58878", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O => 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653974", "l": "Ragulator binds Rag dimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654729", "l": "p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798745", "l": "Exocytosis of tertiary granule lumen proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028629", "l": "Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1433514", "l": "Synthesis of PIP3 from PIP2 by PI3K (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57259", "l": "H2O + N(2)-(1-hydroxy-2-oxopropyl)-GTP <=> GTP + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15170", "l": "H2O + N-succinyl-L-glutamate => L-glutamate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17653", "l": "(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate", "d": [], "t": []}, {"i": "EC:2.5.1.29", "l": "\"geranylgeranyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.68", "l": "\"Ulp1 peptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70817", "l": "H(+)(out) + L-histidine(out) + L-ornithine(in) => H(+)(in) + L-histidine(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37471", "l": "3-methylbutanoyl-CoA + S-adenosyl-L-methionine = CoA + H(+) + N-isovaleryl-L-homoserine lactone + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.3.1.228", "l": "\"isovaleryl-homoserine lactone synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5690157", "l": "USP16,USP21 deubiquitinate Histone H2A (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10198", "l": "2-succinylbenzoate + H2O => (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30109", "l": "2-aminomalonate semialdehyde + H(+) + NADPH => D-serine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-198714", "l": "ERK5 translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052926", "l": "dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity", "d": ["Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-177942", "l": "EGFR binds EGF ligand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5602472", "l": "Defective IRAK4 does not form a complex with MyD88 within the TLR5 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41592", "l": "15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0042015", "l": "interleukin-20 binding", "d": ["Binding to interleukin-20."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200646", "l": "Cytosolic folate export across the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58508", "l": "(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O = (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69821", "l": "H2O + NADP(+) + taurine => H(+) + hypotaurine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47530", "l": "isocholate + NADP(+) => 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-187574", "l": "Degradation of ubiquitinated p27/p21 by the 26S proteasome (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17094", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) => 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60253", "l": "(S)-methylmalonyl-CoA + NADP(+) => acryloyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5694583", "l": "ABHD4 hydrolyses NAPE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9617996", "l": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34135", "l": "cannabigerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57288", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O = a guanosine in RNA + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29936", "l": "cytosine(in) + H(+)(in) => cytosine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28091", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191402", "l": "Reduction of presqualene diphosphate to form squalene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38951", "l": "ATP + H2O + sphing-4-enine 1-phosphate(in) = ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46774", "l": "a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => 1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74467", "l": "a 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol + H2O = a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26434", "l": "indole + L-serine = H2O + L-tryptophan", "d": [], "t": []}, {"i": "EC:4.2.1.122", "l": "\"tryptophan synthase (indole-salvaging)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.1.3.n3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21863", "l": "3'-phosphoadenylyl sulfate + quercetin 3,3'-bissulfate <=> adenosine 3',5'-bisphosphate + H(+) + quercetin 3,3',7-trissulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28046", "l": "phosphate + propanoyl-CoA = CoA + propanoyl phosphate", "d": [], "t": []}, {"i": "EC:2.3.1.222", "l": "\"phosphate propanoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047460", "l": "L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity", "d": ["Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate + H2O = 2-oxopent-4-enoate + chloride + H+ + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51497", "l": "a sphingoid base + ATP => a sphingoid 1-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9035960", "l": "Defective CYP27A1 does not 27-hydroxylate 5β-CHOL3α,7α,24(s)-triol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30849", "l": "(2E)-butenoyl-CoA + CO2 + FADH2 => FAD + glutaryl-CoA + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64846", "l": "(2E)-geranyl benzoate + CoA => (2E)-geraniol + benzoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5671749", "l": "p-T774-PKN1 phosphorylates CDC25C (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20472", "l": "H2O + IMP <=> D-ribose 5-phosphate + hypoxanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5652195", "l": "SORD oxidizes D-sorbitol to Fru (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74707", "l": "Binding of IRS to insulin receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013022", "l": "RHOB GAPs stimulate RHOB GTPase activity (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18880", "l": "myo-inositol + S-adenosyl-L-methionine <=> 1D-3-O-methyl-myo-inositol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047124", "l": "L-erythro-3,5-diaminohexanoate dehydrogenase activity", "d": ["Catalysis of the reaction: (3S,5S)-3,5-diaminohexanoate + H2O + NAD+ = (S)-5-amino-3-oxo-hexanoate + H+ + NADH + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8952128", "l": "RUNX3 binds TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730844", "l": "Interaction of GRB2:SOS complex with p-SHC1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382061", "l": "Extracellular processing of novel PDGFs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71879", "l": "2'-deoxyguanosine + NAD(+) = H(+) + N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114553", "l": "Activation of conventional Protein Kinase C (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50708", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-72670", "l": "Formation of eIF2:GDP:eIF2B intermediate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.13", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17810", "l": "Mg-protoporphyrin IX + S-adenosyl-L-methionine => Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37323", "l": "glycyl-L-methionine + H2O = glycine + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32707", "l": "(2E)-geranyl diphosphate = (2R,4S)-bornyl diphosphate", "d": [], "t": []}, {"i": "EC:5.5.1.22", "l": "\"(-)-bornyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3215152", "l": "TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168886", "l": "Hemopexin binds Hemes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48344", "l": "an N-acyl-sphingoid base + UDP-alpha-D-galactose = a D-galactosylceramide + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76030", "l": "(S)-reticuline + 2-oxoglutarate + O2 <=> (S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14569", "l": "propane-1,2-diol = H2O + propanal", "d": [], "t": []}, {"i": "EC:4.2.1.28", "l": "\"propanediol dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32463", "l": "glycine + 2 S-adenosyl-L-methionine = 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.156", "l": "\"glycine/sarcosine N-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63221", "l": "7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine(15) in tRNA + S-adenosyl-L-methionine => 5'-deoxyadenosine + archaeosine(15) in tRNA + 2 H(+) + L-1-piperideine-6-carboxylate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9840408", "l": "OMA1 cleaves DELE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030944", "l": "DDEL sequence binding", "d": ["Binding to a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0047708", "l": "biotinidase activity", "d": ["Catalysis of the reaction: biotin amide + H2O = biotin + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9634169", "l": "POM121 and NDC1 bind the Nup93 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53222", "l": "6beta,16alpha,17alpha-trihydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 16alpha,17alpha-dihydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-73608", "l": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9015122", "l": "Factor Xa inhibitors bind Va:Xa (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5690066", "l": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2022856", "l": "EXT1:EXT2 transfers GlcNAc to heparan (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1483182", "l": "PC is hydrolyzed to PA and choline by PLD1/2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "74.47181484816187", "identifiers": [{"i": "GO:0008175", "l": "tRNA methyltransferase activity", "d": ["Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8848713", "l": "PTK6 binds BCAR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55263", "l": "2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64192", "l": "H2O + N-(9Z-octadecenoyl)-L-lysine = (9Z)-octadecenoate + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49144", "l": "2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate", "d": [], "t": []}, {"i": "EC:2.6.1.110", "l": "\"dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6801776", "l": "REG3A binds bacterial phospholipids (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66344", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + ATP + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-879917", "l": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159046", "l": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41606", "l": "1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine => 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084978", "l": "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11397", "l": "5-methyldeoxycytidine 5'-phosphate + ATP => 5-methyldeoxycytidine diphosphate + ADP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19569", "l": "5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.61", "l": "\"tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9825790", "l": "p-S207 KARS1 dimer synthesizes A(5')p4(5')A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42594", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-706479", "l": "TAK1 is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "66.45043725250369", "identifiers": [{"i": "GO:0005254", "l": "chloride channel activity", "d": ["Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.79", "l": "\"succinate-semialdehyde dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6803771", "l": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30520", "l": "GTP + H(+) + phosphoenolpyruvate => diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051997", "l": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity", "d": ["Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654717", "l": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043817", "l": "phosphosulfolactate synthase activity", "d": ["Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75914", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine <=> a fatty acid + H(+) + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654985", "l": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39745", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668404", "l": "TNFA binds TNFR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0051002", "l": "ligase activity, forming nitrogen-metal bonds", "d": ["Catalysis of the joining of a metal ion to a molecule via a nitrogen-metal bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate."], "t": []}, {"i": "EC:6.6.-.-", "l": "\"Forming nitrogen-metal bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53476", "l": "1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204861", "l": "Interaction of Tie2 and Shc1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67298", "l": "(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2 => (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111804", "l": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28528", "l": "(R)-carnitinyl-CoA + crotonobetaine => (R)-carnitine + crotonobetainyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047597", "l": "6-oxocineole dehydrogenase activity", "d": ["Catalysis of the reaction: 6-oxocineole + H+ + NADPH + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2855125", "l": "Ficolin-1 binds to molecular patterns on the target cell surface (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69531", "l": "chorismate + H2O + 2 L-glutamine <=> 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "46.902166367084959", "identifiers": [{"i": "GO:0005488", "l": "binding", "d": ["The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9624527", "l": "AKT-phosphorylated FOXO3 translocates to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23007", "l": "a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine <=> a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53651", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (+)-corvol ether A + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-210290", "l": "Interaction of PECAM-1 and SHIP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73573", "l": "CAD hexamer transforms CAP to N-carb-L-Asp (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6809287", "l": "NUDT12 hydrolyses NADH to NMNH (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51184", "l": "1-octadecanoyl-sn-glycero-3-phosphoserine + H2O = H(+) + octadecanoate + sn-glycero-3-phospho-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32002", "l": "(2E,6E)-farnesyl diphosphate <=> bicyclogermacrene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140700", "l": "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1855181", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9617833", "l": "SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8950269", "l": "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4420107", "l": "p-6Y-VEGFR2 binds SHC-transforming protein 2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8987070", "l": "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31835", "l": "dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-galactose", "d": [], "t": []}, {"i": "EC:5.3.2.3", "l": "\"TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (dTDP-3-dehydro-6-deoxy-alpha-D-galactopyranose-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28221", "l": "chloride + H(+) + H2O2 <=> H2O + hypochlorous acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19645", "l": "a D-threo-aldose + NAD(+) = a D-threo-aldono-1,5-lactone + H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.122", "l": "\"D-threo-aldose 1-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70979", "l": "MDH2 dimer dehydrogenates MAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79128", "l": "L-phenylalanine + taurocholate => L-phenylalanocholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1475435", "l": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.136", "l": "\"gallate 1-beta-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0070653", "l": "high-density lipoprotein particle receptor binding", "d": ["Binding to a high-density lipoprotein receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-429978", "l": "Lsm1-7 Complex binds deadenylated mRNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694542", "l": "nsp14 binds nsp10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9686920", "l": "PELI1 ubiquitinates RIPK3 at K363 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53612", "l": "CTP + D-ribulose 5-phosphate + H(+) = CDP-D-ribulose + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004831", "l": "tyrosine-tRNA ligase activity", "d": ["Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9824882", "l": "IKKε (IKBKE) is phosphorylated within the activated TLR4 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2089927", "l": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102825", "l": "quercetin 3-O-rhamnoside-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose(2-) + quercetin 3-O-rhamnoside = quercetin 3-O-rhamnoside-7-O-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5419271", "l": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54187", "l": "an N-acyl-aromatic L-alpha-amino acid + H2O <=> a carboxylate + an aromatic L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-71218", "l": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-195378", "l": "Homodimerization of VEGF proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162857", "l": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-72621", "l": "Ribosomal scanning  (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8939829", "l": "ITGBL1 gene expression is stimulated by RUNX2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005168", "l": "neurotrophin TRKA receptor binding", "d": ["Binding to a neurotrophin TRKA receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47008", "l": "[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide = [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3788708", "l": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9603784", "l": "PEX19:class I PMP binds PEX3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047244", "l": "N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity", "d": ["Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9035484", "l": "CysS248-MPST:TXN2 dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762094", "l": "GSK3B phosphorylates p-NFE2L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22769", "l": "4-nitrophenyl-3-ketovalidamine => 4-nitroaniline + 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72806", "l": "L-arginine(out) + N(omega)-methyl-L-arginine(in) <=> L-arginine(in) + N(omega)-methyl-L-arginine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8858500", "l": "CLEC10A binds Tn-MUC1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-354066", "l": "Translocation of PTK2 to Focal complexes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-167686", "l": "Active PLCG1 hydrolyses PIP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5251942", "l": "Hikeshi binds HSP70s:ATP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047156", "l": "acetoin-ribose-5-phosphate transaldolase activity", "d": ["Catalysis of the reaction: D-ribose 5-phosphate + acetoin = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36180", "l": "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline => 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39476", "l": "(3R)-hydroxy-(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA => (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69169", "l": "H2O + NAD(+) + spermine monoaldehyde => 2 H(+) + N-(2-carboxyethyl)spermidine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209845", "l": "CYP2R1 25-hydroxylates VD3 to 25(OH)D (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750617", "l": "ABCC5 transports TPMP substrates from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64580", "l": "(2Z,6Z)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + nerylneryl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61925", "l": "(2S,4R)-ketoconazole(in) + ATP + H2O => (2S,4R)-ketoconazole(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1606807", "l": "ARSA removes sulfate from PSAP(195-273):Sulfatide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9699579", "l": "AKT phosphorylates FOXO3 downstream of FLT3  (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483142", "l": "PC is transphosphatidylated to PG by PLD1-4/6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68171", "l": "N-(8'-oxogeranyl)-L-glutamate + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + N-(7'-carboxy-7'-demethylgeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71130", "l": "H(+)(in) + L-glutamine(out) + Na(+)(out) <=> H(+)(out) + L-glutamine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4724330", "l": "Defective ALG8 does not add glucose to the N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34870", "l": "ATP + CoA + thiophene-2-carboxylate <=> AMP + diphosphate + thiophene-2-carbonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807126", "l": "Deubiquitinated PTEN translocates to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799761", "l": "TP53 binds PPP1R13L (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71735", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic] (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73313", "l": "L-thyroxine sulfate(in) => L-thyroxine sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31154", "l": "H2O + L-selenocystathionine <=> 2-oxobutanoate + L-selenocysteine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44900", "l": "D-galactono-1,4-lactone + H2O = D-galactonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9647994", "l": "RAS proteins are depalmitoylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4086083", "l": "SUMOylation of ING2 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39608", "l": "(2E,12Z,15Z,18Z,21Z,24Z,27Z)-triacontaheptaenoyl-CoA + H(+) + NADPH => (12Z,15Z,18Z,21Z,24Z,27Z)-triacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23543", "l": "ATP + L-glutamate + tRNA(Glu) <=> AMP + diphosphate + L-glutamyl-tRNA(Glu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77073", "l": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033949", "l": "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-380780", "l": "Activation of Src (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67559", "l": "3'-phosphoadenylyl sulfate + glycocholate <=> adenosine 3',5'-bisphosphate + glycocholate 7-sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-158721", "l": "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15594", "l": "amicoumacin A 2-phosphate + H2O => amicoumacin A + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170810", "l": "nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-450580", "l": "AUF1 (hnRNP D0) is ubiquitinylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193702", "l": "Part of the ICD migrates to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9627106", "l": "SMAC (DIABLO) forms dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8867370", "l": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20288", "l": "beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate <=> alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73823", "l": "an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632182", "l": "PRMT1 methylates ESRs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22855", "l": "L-serine + pyruvate <=> 3-hydroxypyruvate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-74249", "l": "PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-71275", "l": "arginine + glycine => ornithine + guanidoacetate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654591", "l": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1855153", "l": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48382", "l": "a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+) => alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12341", "l": "L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] => H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8952726", "l": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375473", "l": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67839", "l": "1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine <=> 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-350408", "l": "PK binds to VANG at the plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18310", "l": "an N-acyl-D-amino acid + H2O => a carboxylate + a D-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211289", "l": "MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43884", "l": "3-oxochol-4-en-22-oyl-CoA + NAD(+) = 3-oxochola-1,4-dien-22-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9603804", "l": "PEX19 binds class I peroxisomal membrane proteins (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37347", "l": "(R)-lactate + ATP + D-alanine = ADP + D-alanyl-(R)-lactate + phosphate", "d": [], "t": []}, {"i": "EC:6.1.2.1", "l": "\"D-alanine--(R)-lactate ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65394", "l": "(8aS)-octahydroindolizin-1-one + CO2 + CoA + 2 H2O + 2 NADP(+) => 4 H(+) + L-pipecolate + malonyl-CoA + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047942", "l": "glutamate-ethylamine ligase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP + ethylamine = N(5)-ethyl-L-glutamine + ADP + 2 H+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-177944", "l": "Activation of SHP2 through the binding to phospho-Gab1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050202", "l": "octopamine dehydratase activity", "d": ["Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH4."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49634", "l": "(3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+) => (2E,6E)-farnesyl diphosphate + 3,5-dimethylorsellinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-606349", "l": "Mis18 complex binds the centromere (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8955285", "l": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211219", "l": "Translocation of caspase-3 to the nucleus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0039552", "l": "RIG-I binding", "d": ["Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200410", "l": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41240", "l": "N-[omega-(9Z,12Z)-octadecadienoyloxy]-acylsphin-4-enine + O2 => N-acyl (9R)-hydroperoxy-(10E,12Z)-octadecadienoate octadecasphing-4E-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791155", "l": "Expression of EDEM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14187", "l": "2-phenylacetaldehyde + CO2 => 3-phenylpyruvate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28437", "l": "(9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + tetradecanoyl-[ACP] <=> ((9Z)-hexadecenoyl-tetradecanoyl)-(Kdo)2-lipid A + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21530", "l": "[phosphate](n-1) + H(+) + phosphate => [phosphate](n) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852266", "l": "C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.2.27", "l": "\"uracil-DNA glycosylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194017", "l": "CYP11B2 oxidises 11DCORST to CORST (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9018787", "l": "RHOBTB2 binds interacting proteins at the endosome membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40411", "l": "1,2-dihexadecanoyl-sn-glycero-3-CDP + myo-inositol = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11495", "l": "H(+) + O-phospho-L-threonine <=> (R)-1-aminopropan-2-yl phosphate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76442", "l": "19-hydroxy-11-deoxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> 19-oxo-11-deoxycorticosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36310", "l": "(E)-caffeoyl-CoA + H2O <=> 3,4-dihydroxybenzaldehyde + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63814", "l": "AMP + diphosphate + H(+) + N(8),N'(8)-citryl-bis(spermidine) => ATP + N(8)-citryl-spermidine + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9757257", "l": "MCM4, MCM6 and MCM7 form a heterotrimer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38732", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 3-hexadecanoyl-sn-glycerol => (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "65.261721605447917", "identifiers": [{"i": "GO:0015399", "l": "primary active transmembrane transporter activity", "d": ["Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical such as ATP hydrolysis, redox energy and photon energy."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004394", "l": "heparan sulfate 2-O-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate."], "t": []}, {"i": "REACT:R-HSA-2076508", "l": "HS2ST1 sulfates IdoA at C2 in heparan sulfate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6804596", "l": "APAF1:CYCS binds APIP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56949", "l": "pyruvate + UTP => H(+) + phosphoenolpyruvate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44594", "l": "2-methoxy-6-(all-trans-heptaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-heptaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55507", "l": "(5S,9S,10S)-drim-7-en-11-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> (5S,10S)-(9R)-7-drimene-11,12-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0003691", "l": "double-stranded telomeric DNA binding", "d": ["Binding to double-stranded telomere-associated DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12666", "l": "a 2-deoxystreptamine antibiotic + acetyl-CoA => an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40219", "l": "H2O + malonyl-CoA = CoA + H(+) + malonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22989", "l": "3-oxopropanoate + CoA + NADP(+) => acetyl-CoA + CO2 + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975593", "l": "PNLIP:CLPS hydrolyses RPALM to atROL and PALM (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72807", "l": "L-histidine(out) = L-histidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41087", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-429571", "l": "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3223236", "l": "RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75886", "l": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30687", "l": "(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-392054", "l": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30562", "l": "GTP + H2O <=> guanosine + H(+) + triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38324", "l": "2 1-(9Z-octadecenoyl)-glycerol => 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59609", "l": "beta-alanyl-L-lysine + H2O => beta-alanine + L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649705", "l": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35274", "l": "a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004446", "l": "inositol-hexakisphosphate phosphatase activity", "d": ["Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001609", "l": "G protein-coupled adenosine receptor activity", "d": ["Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5229194", "l": "Depolymerization of lamin filaments after PKC-mediated phosphorylation (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.166", "l": "\"heparanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40150", "l": "eicosanoyl-CoA + H2O <=> CoA + eicosanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000383", "l": "UBE2I, HDAC7 SUMOylate PML with SUMO1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41769", "l": "a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate => a ganglioside GT1a (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57655", "l": "a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GM1alpha + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9012016", "l": "FAHD1 dimer hydrolyses OA to PYR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.9.-", "l": "\"With a copper protein as acceptor\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2990880", "l": "NEK6/NEK7 phosphorylates NUP98 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33555", "l": "an N-acyl-(4R)-4-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + a fatty acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47339", "l": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] <=> 16beta,17beta-estriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9773803", "l": "Active IKBKB phosphorylates NF-kappa-B inhibitor  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14445", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74997", "l": "epierythrostominol(out) => epierythrostominol(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29411", "l": "glycolate(in) + H(+)(in) = glycolate(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-428259", "l": "DEGS1 dehydrogenates dihydroceramide (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875071", "l": "ACSS3 ligates CoA to CH3COO- (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30451", "l": "(S)-2,3-epoxysqualene = isomultiflorenol", "d": [], "t": []}, {"i": "EC:5.4.99.36", "l": "\"isomultiflorenol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31215", "l": "(5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD(+) = (5-hydroxyindol-3-yl)acetate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-984606", "l": "Kinesin-5 is a homotetramer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43142", "l": "2 H(+) + N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine => guanosine(26) in tRNA + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31283", "l": "FAD + H(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49336", "l": "2,2-dihydroxyspheroidene = H2O + spheroiden-2-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678854", "l": "GUSB tetramer hydrolyses CS/HS precursor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-198640", "l": "TORC2 (mTOR) phosphorylates AKT at S473 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9707419", "l": "CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9021627", "l": "EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373791", "l": "Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23415", "l": "H2O + N-acetylputrescine <=> acetate + putrescine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1482777", "l": "TAG is hydrolyzed to DAG by PNPLA2/3 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3928646", "l": "EPHAs bind EFNAs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59427", "l": "benzylamine + H2O + O2 <=> benzaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22613", "l": "(3S)-citramalyl-CoA => acetyl-CoA + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848993", "l": "Phosphorylated KHDRBS1 translocates to the cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23749", "l": "ATP + GTP => diphosphate + pppGp(2'-5')A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24487", "l": "NAD(+) + sulcatol <=> H(+) + NADH + sulcatone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-205238", "l": "SHP2 interacts with p-KIT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3965444", "l": "WNT:FZD complex promotes G-protein nucleotide exchange (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015541", "l": "secondary active cyanate transmembrane transporter activity", "d": ["Enables the transfer of cyanate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47934", "l": "(2S)-3-sulfolactate + 2 H(+) + NADH => (2S)-3-sulfolactaldehyde + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58565", "l": "15alpha-stemmadenine + NADP(+) => 15alpha-stemmadenine intermediate II + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11780", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.134", "l": "\"galactosylxylosylprotein 3-beta-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042806", "l": "fucose binding", "d": ["Binding to fucose, the pentose 6-deoxygalactose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534248", "l": "DCN (decorin) degradation by MMP2, MMP3, MMP7 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37335", "l": "5,6-dihydrothymine + H2O = 3-(carbamoylamino)-2-methylpropanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5696839", "l": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48304", "l": "a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14465", "l": "H2O + L-histidinol phosphate = L-histidinol + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.15", "l": "\"histidinol-phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0015277", "l": "kainate selective glutamate receptor activity", "d": ["An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.n1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68422", "l": "(2R,3S)-iso(homo)3citrate => cis-(homo)3aconitate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54980", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28465", "l": "pyridoxal(in) <=> pyridoxal(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1602488", "l": "Initial activation of proMMP13 by plasmin and trypsin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55888", "l": "[aequorin]--dioxetanone = [excited state blue fluorescent protein] + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49499", "l": "2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) <=> 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17268", "l": "trans-aconitate <=> cis-aconitate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018121", "l": "NAD(P)-asparagine ADP-ribosyltransferase activity", "d": ["Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050249", "l": "Renilla-luciferin sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + Renilla luciferin = adenosine 3',5'-diphosphate + H+ + luciferyl sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56182", "l": "2-oxoglutarate + 8-amino-8-demethylriboflavin 5'-phosphate + 2 AH2 + CO2 => 8-carboxy-8-demethylriboflavin 5'-phosphate + 2 A + H2O + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396599", "l": "Recruitment of GRB2:SOS to p-5Y-LAT (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70178", "l": "beta-D-glucosyl-(1->4)-D-galactose + phosphate <=> alpha-D-glucose 1-phosphate + D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5690991", "l": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72649", "l": "1,6-dihydroxyphenazine N(5)-oxide + H2O + NADP(+) => 1,6-dihydroxyphenazine + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.158", "l": "\"carotene epsilon-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17082", "l": "(E)-isoeugenol + S-adenosyl-L-methionine => (E)-isomethyleugenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71807", "l": "a 2'-deoxyguanosine in DNA + NAD(+) = an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40850", "l": "eicosanoyl-CoA + FAD + H(+) <=> (2E)-eicosenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-416985", "l": "Trafficking of GluR2-containing AMPA receptors to synapse (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374701", "l": "Phosphorylation of DCC by Fyn (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28792", "l": "5,6-dihydrothymine + NAD(+) => H(+) + NADH + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3214912", "l": "KDM1A, KDM1B demethylate MeK5-histone H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350869", "l": "Thyroxine is deiodinated to reverse triiodothyronine (RT3) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46620", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55405", "l": "[phosphate](n) + UTP => [phosphate](n+1) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52743", "l": "glyphosate + H2O + O2 <=> aminomethylphosphonate + glyoxylate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9845055", "l": "PLEKHA8 catalyzes transport of GlcCer to plasma membrane (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654986", "l": "SPRTN binds monoUb:K164-PCNA associated with POLH (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5433072", "l": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2997709", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9615638", "l": "EGR2 and SOX10 bind the MBP gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41545", "l": "8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine => 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-212263", "l": "PRC2 trimethylates histone H3 at lysine-27 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9008694", "l": "IL37, IL37(?-218) translocates from cytosol to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2473594", "l": "Collagen type II degradation by MMP15 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6788623", "l": "p-Y-STATs translocate to nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19062", "l": "H2O + NADP(+) + nitrite => H(+) + NADPH + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5693783", "l": "NAALADases hydrolyse NAAG (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848930", "l": "PTK6 translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655842", "l": "S1P hydrolyzes SREBP1A,1C,2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-422017", "l": "Ghrelin O-acyltransferase decanoylates Proghrelin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654406", "l": "Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654566", "l": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5334794", "l": "FABPs bind LCFAs (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28230", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = (+)-costunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.150", "l": "\"costunolide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43512", "l": "2-(dihydroxymethyl)-5-formylfuran + O2 = 2-carboxy-5-formylfuran + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9708536", "l": "HMOX1 translocates from the cytosol to the nucleoplasm (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46618", "l": "(23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin] => calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9610156", "l": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34672", "l": "3-methyl-1,2-didehydro-2,3-dihydrobotryococcene + S-adenosyl-L-methionine => 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6803523", "l": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8878654", "l": "ACP6 hydrolyses MYS-LPA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22384", "l": "5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53231", "l": "androst-4-ene-3,17-dione + O2 + reduced [NADPH--hemoprotein reductase] <=> 16alpha-hydroxyandrost-4-ene-3,17-dione + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5218851", "l": "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22155", "l": "a ubiquinone + D-glucose <=> a ubiquinol + D-glucono-1,5-lactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5218812", "l": "FYN phosphorylates PAK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9653108", "l": "Raf dimer inhibitors bind RAF heterodimers (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8851954", "l": "Phosphorylated GAB1 recruits PI3K to MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9656893", "l": "OPN1MW binds 11cRAL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5358579", "l": "DNA polymerase delta polymerizes DNA across single stranded gap (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10773", "l": "6-phospho-beta-D-glucosyl-(1->4)-D-glucose + H2O => D-glucose + D-glucose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5653968", "l": "Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879910", "l": "JAK2 is phosphorylated, activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-351222", "l": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9023968", "l": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62244", "l": "a cytidine(6-4)thymidine in DNA = a cytidine-thymine dinucleotide in DNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44037", "l": "12,13-epoxy-(9Z)-octadecenoate + H2O => 12,13-dihydroxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65646", "l": "CoA + H(+) + N-tetracosanoyl-(4R)-hydroxysphing-(8E)-enine => (4R)-hydroxysphing-(8E)-enine + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-383363", "l": "Tachykinin receptor 2 (NK2) binds to nuerokinin A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52550", "l": "2-dehydro-L-erythronate + H(+) + NADH => L-threonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2089971", "l": "Secretion of collagens (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68051", "l": "[protein]-D-aspartate + S-adenosyl-L-methionine <=> [protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61264", "l": "H2O + L-alanine + O2 = H2O2 + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.4", "l": "\"adenosine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654514", "l": "KAL1 binds FGFR1c (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.28", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193070", "l": "CYP17A1 cleaves 17aHPREG to DHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59338", "l": "AH2 + demethylspheroidene => 1-hydroxy-all-trans-1,2-dihydro-neurosporene + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24953", "l": "1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O => ADP + H(+) + N-acetyl-D-muramate 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619034", "l": "ACEIs translocate from ER lumen to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-112430", "l": "Formation of P-TEFb complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67830", "l": "a lipid A disaccharide + H(+) + UDP => a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25774", "l": "(2S,3S)-3-hydroxyasparagine + CO2 + succinate => 2-oxoglutarate + L-asparagine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6788295", "l": "HDHD1:Mg2+ dephosphorylates PURIDP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482689", "l": "1-acyl LPG is acylated to PG by CRLS1 (IM) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-197268", "l": "QPRT transfers PRIB to QUIN to form NAMN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30277", "l": "A + 2 H2O => AH2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13118", "l": "O-acetyl-L-serine + pyrazole => 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9756177", "l": "PON1,3 hydrolyse ATVL to ATV (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41114", "l": "1-hexadecanoyl-2-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + H2O <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40132", "l": "(9Z)-hexadecenoyl-CoA + H2O => (9Z)-hexadecenoate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64520", "l": "acetyl-CoA + AH2 + 3 H(+) + 3 malonyl-CoA = A + 3 CO2 + 4 CoA + H2O + orsellinaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29941", "l": "H(+)(out) + phosphate(out) => H(+)(in) + phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33264", "l": "L-phenylalanine + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => (E)-phenylacetaldehyde oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5336182", "l": "GPR37 binds prosaptide (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74715", "l": "Autophosphorylation of insulin receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57301", "l": "an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O => a 2'-deoxyguanosine in DNA + H(+) + lactate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-416929", "l": "PTGFR binds PGF2a (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62534", "l": "dihydrodigitoxin + 2 Fe(III)-[cytochrome c] => digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-939265", "l": "Activation of Rap1 by membrane-associated GEFs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15406", "l": "(3R)-3-hydroxybutanoyl-CoA + [(3R)-hydroxybutanoate](n) => [(3R)-hydroxybutanoate](n+1) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.175", "l": "\"glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162253", "l": "PDSS1,2 ligates FPP to IPPP (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29333", "l": "fumarate(out) + 2 H(+)(out) => fumarate(in) + 2 H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.135", "l": "\"neopullulanase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20249", "l": "L-alanine = D-alanine", "d": [], "t": []}, {"i": "EC:5.1.1.1", "l": "\"alanine racemase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8954082", "l": "E2F6 binds the PRC1 complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15945", "l": "aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] = H2O + N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8862300", "l": "LYZ binds bacterial peptidoglycan (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69708", "l": "beta-D-galactosyl-(1<->1')-N-hexadecanoylsphinganine + H2O => beta-D-galactose + N-hexadecanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28854", "l": "melibiose(in) + Na(+)(in) <=> melibiose(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102705", "l": "serine decarboxylase activity", "d": ["Catalysis of the reaction: H+ + L-serine = ethanolaminium(1+) + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28066", "l": "CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39372", "l": "3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23215", "l": "H2O + N-acetyl-beta-alanine <=> acetate + beta-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-196350", "l": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4608854", "l": "SMURF1/2 are recruited to the DVL2:PARD6A complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6782204", "l": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39521", "l": "(3R)-hydroxy-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + NADP(+) => 3-oxo-(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5679205", "l": "ULK1 phosphorylates Beclin-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74862", "l": "dopamine + formaldehyde <=> H2O + norsalsolinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-197958", "l": "FPGS-2 transforms THF to THFPG (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50488", "l": "acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350604", "l": "Agmatine + H2O <=> putrescine + urea (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52829", "l": "(1S,4R)-isodihydrocarvone + H(+) + NADPH + O2 => (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814684", "l": "cis-SNARE binds SNAPs and NSF hexamer at the TGN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49510", "l": "2-(phosphinatomethylidene)butanedioate + H2O => phosphinomethylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9825759", "l": "MAPK-dependent phosphorylation of KARS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034538", "l": "3-methylsalicylaldehyde dehydrogenase activity", "d": ["Catalysis of the reaction: 3-methylsalicylaldehyde + NAD+ = 3-methylsalicylate + NADH + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.2.62", "l": "\"5-deoxyribulose 1-phosphate aldolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3928617", "l": "EPHB2 binds KALRN (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200681", "l": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653886", "l": "B4GALT1 binds LALBA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4085021", "l": "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9757574", "l": "ALB binds PREDL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9717830", "l": "GGPS1 hexamer transfers IPPP to GPP (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10073", "l": "N,N-dimethylglycine + S-adenosyl-L-methionine => glycine betaine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40512", "l": "(2S)-3-sulfopropanediol + NAD(+) => (2S)-3-sulfolactaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5251989", "l": "ATP13A4,5 transport divalent ions from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32029", "l": "(-)-alpha-cuprenene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008997", "l": "ribonuclease R activity", "d": ["Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17054", "l": "D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate => beta-D-fructose 6-phosphate + D-erythrose 4-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618107", "l": "ATP binding to HSP90 triggers conformation change (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44226", "l": "16-hydroxyhexadecanoyl-CoA + AMP + diphosphate => 16-hydroxyhexadecanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72125", "l": "Na(+)(in) + O-butanoyl-(R)-carnitine(in) => Na(+)(out) + O-butanoyl-(R)-carnitine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428750", "l": "Gq activation by TP receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62853", "l": "GDP-beta-L-fucose + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate => GDP + H(+) + methyl 8-{[alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl]oxy}nonanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54060", "l": "(2E,6E)-farnesyl diphosphate + H2O = (2Z,6E)-hedycaryol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.187", "l": "\"(2Z,6E)-hedycaryol synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17758", "l": "H(+) + L-methionine => 3-(methylsulfanyl)propanamine + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17658", "l": "an acyl-CoA + dihydroxyacetone phosphate => a 1-acylglycerone 3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045352", "l": "interleukin-1 type I receptor antagonist activity", "d": ["Blocks the binding of interleukin-1 to interleukin-1 type I receptors."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9695917", "l": "SPHK2 binds SPHK2 inhibitors (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56450", "l": "(9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-163402", "l": "diacylglycerol + H2O -> 2-acylglycerol + fatty acid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-173709", "l": "C7 binds C5b:C6 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102570", "l": "tyrosine:phenylpyruvate aminotransferase activity", "d": ["Catalysis of the reaction: keto-phenylpyruvate + L-tyrosine = L-phenylalanine + 3-(4-hydroxyphenyl)pyruvate."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1475026", "l": "Carbonic anhydrase hydrates carbon dioxide (cytosol) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25591", "l": "D-threo-isocitrate + NADP(+) <=> (S)-oxalosuccinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20731", "l": "H2O + L-glutamate + O2 <=> 2-oxoglutarate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2197646", "l": "SCARB1 (SR-BI, CLA-1) binds ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034027", "l": "(carboxyethyl)arginine beta-lactam-synthase activity", "d": ["Catalysis of the reaction: N(2)-(2-carboxyethyl)-L-arginine + ATP = AMP + deoxyamidinoproclavaminate + diphosphate + 2 H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855180", "l": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-390909", "l": "HRH2 binds hist (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9638076", "l": "HEXB cleaves the terminal GalNAc from small HA fragments (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59532", "l": "(S)-reticuline + S-adenosyl-L-methionine = (S)-codamine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35690", "l": "NADP(+) + tetradecasphinganine <=> 3-oxotetradecasphinganine + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2168136", "l": "NOTCH3 binds DLL4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53321", "l": "alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose => alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004025", "l": "alcohol dehydrogenase (NAD+) activity, iron-dependent", "d": ["Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30591", "l": "H2O + O2 + tyramine = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45971", "l": "androst-4-ene-3,17-dione + H(+) + NADH + O2 <=> 9alpha-hydroxy-androst-4-ene-3,17-dione + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75544", "l": "(3R)-3-[(carboxylmethyl)amino]decanoate + H(+) + holo-[ACP] => (2E)-decenoyl-[ACP] + glycine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25059", "l": "(E)-cinnamate + H(+) + NADH + O2 => (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9754964", "l": "ADA deamidates RBV (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-419462", "l": "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24524", "l": "20-oxo-5-O-beta-D-mycaminosyltylonolide + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-O-beta-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.34", "l": "\"20-oxo-5-O-mycaminosyltylactone 23-monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9629578", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5687653", "l": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-109699", "l": "PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75517", "l": "acetate + L-cysteine => H2O + N-acetyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22795", "l": "isonocardicin A <=> nocardicin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77590", "l": "Recruitment of CstF to the CPSF Bound Pre-mRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1604350", "l": "MMP14:TIMP2 binds proMMP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-72663", "l": "De novo formation of eIF2:GTP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9613264", "l": "Class III antiarrhythmics bind KCNH2 in KCNH2:KCNE (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-114544", "l": "p115-RhoGEF activation of RHOA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58115", "l": "1''-O-acetyl-ADP-alpha-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42359", "l": "(9Z)-tetradecenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(11Z)-hexadecenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2396029", "l": "Latent TGF-beta-3 binds integrins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28735", "l": "H(+)(in) + spermidine(out) = H(+)(out) + spermidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19721", "l": "2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.19.1", "l": "\"stearoyl-CoA 9-desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59725", "l": "D-maltoheptaono-1,5-lactone + H2O => D-maltoheptaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51898", "l": "acetate + spermine => H2O + N(1)-acetylspermine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6806732", "l": "GNLY binds the bacterial cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25342", "l": "H2O + urea = carbamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690785", "l": "BAP1 binds Ub-HCFC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73983", "l": "(2E,6E)-farnesyl diphosphate = (-)-beta-barbatene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70104", "l": "H(+) + o-quinone methide + penilactone D => penilactone B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035488", "l": "cytosine/thymine mispair binding", "d": ["Binding to a double-stranded DNA region containing a C/T mispair."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444523", "l": "CXCR5 binds CXCL13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23889", "l": "[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine => [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55029", "l": "an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + S-adenosyl-L-methionine => an N-methylornithine lipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5668467", "l": "2xTNFR2 binds TNFA trimer:TNFR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48840", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043795", "l": "glyceraldehyde oxidoreductase activity", "d": ["Catalysis of the reaction: A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855198", "l": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004948", "l": "calcitonin receptor activity", "d": ["Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6811508", "l": "ING2-bound EP300 acetylates TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9690461", "l": "FKBP1A binds tacrolimus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46302", "l": "2-hydroxytestosterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + reduced [NADPH--hemoprotein reductase] + testosterone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63932", "l": "abscisate(in) + ATP + H2O = abscisate(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71036", "l": "L-phenylalanine(out) + L-serine(in) => L-phenylalanine(in) + L-serine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27302", "l": "7-chloro-L-tryptophan + O2 = 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39326", "l": "(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H(+) + NADPH <=> (3R)-hydroxy-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72043", "l": "L-glutamate(in) + orotate(out) = L-glutamate(out) + orotate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6786012", "l": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72450", "l": "a dicarboxylate(in) + estrone 3-sulfate(out) <=> a dicarboxylate(out) + estrone 3-sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62810", "l": "2 H2O + julichrome Q6-6 + 2 oxidized [2Fe-2S]-[ferredoxin] => H(+) + 2 julichrome Q6 + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74443", "l": "1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(out) + H(+)(out) = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15646", "l": "16 ATP + 16 H2O + N2 + 4 reduced [flavodoxin] => 16 ADP + 18 H(+) + H2 + 2 NH4(+) + 4 oxidized [flavodoxin] + 16 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8953917", "l": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65252", "l": "(2E,6E)-farnesyl diphosphate + 6-hydroxymellein = diphosphate + verruculide C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948232", "l": "Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42993", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O => (R)-nephthenol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58719", "l": "FADH2-C4alpha-hydroperoxide + NADH + rifampicin <=> FADH2 + H(+) + H2O + NAD(+) + rifampicin hemiaminal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56802", "l": "cob(II)yrinate a,c diamide-[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)yrinate a,c diamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6786239", "l": "CYP4V2 omega-hydroxylates DHA to HDoHE (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57625", "l": "dihydro-ML-236C carboxylate + O2 + reduced [NADPH--hemoprotein reductase] => 3alpha-hydroxy-3,5-dihydro-ML-236C carboxylate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641362", "l": "SUMOylation of TOP1 with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.1.n3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76699", "l": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9615348", "l": "AGT(34-41) binds to AGTR2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-75891", "l": "Abortive Initiation After Second Transition (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5339538", "l": "MAGT1 transports Mg2+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68617", "l": "cortisone + H(+) + NADPH => cortisol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31943", "l": "cholest-4-en-3-one + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25S)-3-oxocholest-4-en-26-ol + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912790", "l": "CBL binds CRK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70018", "l": "O2 + reduced [NADPH--hemoprotein reductase] + teasterone <=> 7-oxateasterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6800200", "l": "HPN heterodimer cleaves pro-HGF to form HGF dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47237", "l": "eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72751", "l": "H2O + ochratoxin A = L-phenylalanine + ochratoxin alpha", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75723", "l": "(9Z,12Z)-octadecadienoate + H2O = (10S)-hydroxy-(12Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47911", "l": "6-deoxy-6-sulfo-D-glucono-1,5-lactone + H2O <=> 6-deoxy-6-sulfo-D-gluconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451311", "l": "Activation of Ca-permeable Kainate receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685602", "l": "NCR3LG1 binds NCR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9014295", "l": "RAC2 GAPs stimulate RAC2 GTPase activity (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74456", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(out) + H(+)(out) => 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine(in) + H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13766", "l": "bromochloromethane + H2O => bromide + chloride + formaldehyde + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69367", "l": "6-diazo-5-oxo-L-norleucine + acetyl-CoA <=> CoA + H(+) + N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3769447", "l": "HDAC1:2-containing complex deacetylate histones (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9012315", "l": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847887", "l": "RAB33B:GTP binds RIC1:RGP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3662335", "l": "EP300 acetylates histone H2A, H2B, H3, H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63396", "l": "A + Fe(II)-heme i + H2O = AH2 + Fe(II)-hydroxyheme i", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65955", "l": "2 a quinone + H(+) + NADH <=> 2 a 1,4-benzosemiquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73868", "l": "serotonin(out) => serotonin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.188221489317044", "identifiers": [{"i": "GO:0052745", "l": "inositol phosphate phosphatase activity", "d": ["Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8948039", "l": "FUNDC1 is phosphorylated by CK2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-177926", "l": "Dephosphorylation of PAG by SHP2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65808", "l": "decanoyl-[ACP] + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = dec-9-ynoyl-[ACP] + 4 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.19.78", "l": "\"decanoyl-[acyl-carrier protein] acetylenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1296035", "l": "Activation of Ca2+ activated Potassium channels with  Intermediate conductance (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22419", "l": "3,4-dihydroxybenzoate + H(+) <=> catechol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-210439", "l": "glutamate uptake by astrocytes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0061980", "l": "regulatory RNA binding", "d": ["Binding to a small regulatory RNA, a short RNA (usually 50-200 nt long) that is either independently transcribed or processed from a longer RNA by an RNAse enzyme."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54868", "l": "(2E)-butenoyl-[ACP] + H(+) + NADH = butanoyl-[ACP] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196929", "l": "FLAD1 phosphorylates FMN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45509", "l": "phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin beta-subunit] => (2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin beta-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23124", "l": "2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5-bisphosphate + H2O", "d": [], "t": []}, {"i": "EC:4.1.1.39", "l": "\"ribulose-bisphosphate carboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-176646", "l": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51101", "l": "(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] => 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0004741", "l": "[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity", "d": ["Catalysis of the reaction: O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + H2O = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77299", "l": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50938", "l": "acetoacetyl-CoA + L-glutamate => (3S)-3-aminobutanoyl-CoA + 2-oxoglutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38669", "l": "sphing-4-enine 1-phosphate(out) => sphing-4-enine 1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008795", "l": "NAD+ synthase activity", "d": ["Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4615873", "l": "PIAS2-2 SUMOylates SUZ12 with SUMO1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25908", "l": "an alditol + O2 = an aldose + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41573", "l": "lipoxin A4 + NAD(+) => 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-211910", "l": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9708275", "l": "PDE4A binds PDE4A inhibitors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5682769", "l": "LGI2 binds ADAM22,23 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8848829", "l": "CBL autoubiquitinates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981610", "l": "Neuroglobin binds oxygen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1222516", "l": "Intraphagosomal pH is lowered to 5 by V-ATPase (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13521", "l": "(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate", "d": [], "t": []}, {"i": "EC:1.1.2.4", "l": "\"D-lactate dehydrogenase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873922", "l": "Phosphorylation of STAT1 by JAK kinases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32158", "l": "7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine <=> adenine + epoxyqueuosine(34) in tRNA + 2 H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-429441", "l": "SYK activation by SRC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9755303", "l": "26S proteasome degrades HIFalpha (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36221", "l": "1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate + ethanolamine + H(+) => 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68754", "l": "alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein] => alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-177284", "l": "PKA phosphorylates PDE4B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851900", "l": "SHC1-2 bound to MET recruits GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29746", "l": "2-phenylethylamine(in) <=> 2-phenylethylamine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-374673", "l": "L1 binds RanBPM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63441", "l": "(2R)-3-phosphoglycerate + GTP + H(+) => 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5653770", "l": "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8854612", "l": "TBC1D25 accelerates GTP hydrolysis by RAB33B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64485", "l": "acetyl-CoA + 6 H(+) + holo-[ACP] + 6 malonyl-CoA => 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "87.167921677548108", "identifiers": [{"i": "GO:0000700", "l": "mismatch base pair DNA N-glycosylase activity", "d": ["Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031418", "l": "L-ascorbic acid binding", "d": ["Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20001", "l": "glycolaldehyde + H2O + NAD(+) = glycolate + 2 H(+) + NADH", "d": [], "t": []}, {"i": "EC:1.2.1.21", "l": "\"glycolaldehyde dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.114", "l": "\"N-acyl-aromatic-L-amino acid amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48980", "l": "3,4-dichlorocatechol + O2 = (2Z,4Z)-2,3-dichloromuconate + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55119", "l": "5-methyl-3-oxohexanoyl-[ACP] + H(+) + NADPH <=> (3R)-hydroxy-5-methylhexanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8981926", "l": "RAC1 and CDC42 activate PAK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70102", "l": "H(+) + o-quinone methide + peniphenone D <=> penilactone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37658", "l": "1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42059", "l": "13-cis-retinol + NAD(+) <=> 13-cis-retinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3371590", "l": "HSP70 binds to HSP40:nascent protein (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-977605", "l": "Factor H displaces Bb (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-165680", "l": "Formation of active mTORC1 complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001096", "l": "TFIIF-class transcription factor complex binding", "d": ["Binding to a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43298", "l": "1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + phosphate => 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5693612", "l": "MRN complex bound to DNA ends recruits ATM (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23206", "l": "2-O-caffeoylglucarate + L-quinate => chlorogenate + D-glucarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8985973", "l": "IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "58.166017768857863", "identifiers": [{"i": "GO:0005102", "l": "signaling receptor binding", "d": ["Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58218", "l": "AH2 + serpentine => A + dihydroserpentine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49116", "l": "H(+) + NADPH + O2 + protodeoxyviolaceinate = deoxyviolaceinate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36463", "l": "glycyl-L-glutamate + H2O = glycine + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9714477", "l": "RAC2 binds effectors at the mitochondrial outer membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41712", "l": "a 2-acyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycerol 3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19160", "l": "D-xylonate <=> 2-dehydro-3-deoxy-D-arabinonate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23929", "l": "H2O + N(8)-acetylspermidine => acetate + spermidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63035", "l": "a fatty acylamide + H2O <=> a fatty acid + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51049", "l": "5alpha-androstan-3,17-dione + A => AH2 + androst-4-ene-3,17-dione", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9714924", "l": "TNF-alpha inhibitors bind to soluble TNF trimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5610763", "l": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989768", "l": "Expression of TIAM2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211482", "l": "HNF1A-dependent synthesis of FOXA3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70888", "l": "L-glutamine(in) + L-serine(out) + Na(+)(out) => L-glutamine(out) + L-serine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28123", "l": "ATP + di-trans,octa-cis-undecaprenol => ADP + di-trans,octa-cis-undecaprenyl phosphate + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24643", "l": "ergosteryl 3-beta-D-glucoside + H2O <=> D-glucose + ergosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73815", "l": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.20", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76411", "l": "2',3'-cGAMP(out) + n H(+)(out) = 2',3'-cGAMP(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170677", "l": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8865265", "l": "TFAP2C homodimer binds MYC and KDM5B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-389955", "l": "Beta-tubulin:GTP: Cofactor A+ Cofactor D ->  Beta-tubulin:GTP:Cofactor D + Cofactor A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664880", "l": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8852337", "l": "GTSE1 binds TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.3.37", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4641134", "l": "SMURF2 binds AXIN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36647", "l": "2-hydroxyhexadecanoyl-CoA + sphinganine = CoA + H(+) + N-(2-hydroxyhexadecanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8856945", "l": "PP2A methylation by LCMT1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617815", "l": "BBSome binds RAB3IP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018740", "l": "2'-hydroxybiphenyl-2-sulfinate desulfinase activity", "d": ["Catalysis of the reaction: 2'-hydroxybiphenyl-2-sulfinate + H2O = biphenyl-2-ol + sulfite."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6809521", "l": "BPIF binds bacteria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5617828", "l": "TRIP11:IFT20 dissociates (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-77081", "l": "Formation of the CE:GMP intermediate complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685230", "l": "CHEK1 phosphorylates RAD51 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75365", "l": "thymidine(out) => thymidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41005", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + phosphocholine => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-374662", "l": "Translocation of Ezrin to plasma membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420592", "l": "Transhomodimerization of Nectin-like (Necl) proteins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9724745", "l": "PLG(20-810) binds aprotinin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9759751", "l": "SNAI1 binds the CLDN7 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.130", "l": "\"3-dehydro-L-gulonate 2-dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-113412", "l": "Pol II elongation complex moves on the template as transcript elongates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2327746", "l": "FN1 aggregation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0015928", "l": "fucosidase activity", "d": ["Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30392", "l": "4-methylsulfanyl-2-oxobutanoate + L-glutamine => 2-oxoglutaramate + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-936390", "l": "CYLD mediated deubiquitination of DDX58 (RIG-I) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5138432", "l": "DVL2 is phosphorylated by PKC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35550", "l": "cyclo(L-tyrosyl-L-tyrosyl) + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2 H2O + mycoclysin + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74785", "l": "tyramine(out) => tyramine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11652", "l": "di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-galactose = alpha-D-galactosyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.6", "l": "\"undecaprenyl-phosphate galactose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850997", "l": "TRIM27 binds PTEN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8950733", "l": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64592", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base = a 1,2-diacyl-sn-glycerol + an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202307", "l": "Change of PKC theta conformation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72040", "l": "nicotinate(in) + orotate(out) => nicotinate(out) + orotate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2162194", "l": "COQ7:COQ9 octamer hydroxylates DMQ10H2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25136", "l": "phosphate + pyridoxamine => H2O + pyridoxamine 5'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-75095", "l": "Binding of TFIIE to the growing preinitiation complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15252", "l": "3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose <=> 1-O-galloyl-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9681169", "l": "CRBN binds IMiDs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17857", "l": "O2 + reduced [NADPH--hemoprotein reductase] + taurochenodeoxycholate = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + taurohyocholate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018739", "l": "4-hydroxybenzoyl-CoA thioesterase activity", "d": ["Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102149", "l": "farnesylcysteine lyase activity", "d": ["Catalysis of the reaction: S-[(2E,6E)-farnesyl]-L-cysteine + O2 + H2O = (2-trans,6-trans)-farnesal + L-cysteine + hydrogen peroxide."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77068", "l": "Activation of GT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9839401", "l": "TGFBR3 degradation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70323", "l": "2,3-dioxo-L-gulonate = 2-carboxy-L-lyxonolactone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9755507", "l": "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9844057", "l": "SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72621", "l": "Ribosomal scanning  (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-379432", "l": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5682588", "l": "RNF8 binds phosphorylated MDC1 at DNA DSBs (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58385", "l": "NADP(+) + octan-1-ol => H(+) + NADPH + octanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2160874", "l": "HYAL1 hydrolyses (HA)50 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68312", "l": "1D-myo-inositol 1,2,3,4,5-pentakisphosphate + H2O = 1D-myo-inositol 2,3,4,5-tetrakisphosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019148", "l": "D-cysteine desulfhydrase activity", "d": ["Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015433", "l": "ABC-type peptide antigen transporter activity", "d": ["Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22594", "l": "(9S,13S,15Z)-12-oxophyto-10-15-dienoate => (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4551297", "l": "Defective ALG11 does not transfer Man to the N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6803719", "l": "TP53 binds ZNF385A (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39305", "l": "(2E,11Z,14Z)-eicosatrienoyl-CoA + H2O => (3R)-hydroxy-(11Z,14Z)-eicosadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176059", "l": "GST trimers transfer GS from GSH to luminal substrates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71949", "l": "N-acetyl-L-aspartate(in) + 3 Na(+)(in) => N-acetyl-L-aspartate(out) + 3 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5686625", "l": "LAIR1 binds collagen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20751", "l": "2-oxoglutarate + O2 + penicillin N <=> CO2 + deacetoxycephalosporin C + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5423653", "l": "MGST trimers transfer GS from GSH to AFXBO and AFNBO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76080", "l": "a dicarboxylate(in) + L-sepiapterin(out) => a dicarboxylate(out) + L-sepiapterin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.294", "l": "\"chlorophyll(ide) b reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70264", "l": "1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 1D-myo-inositol 1,3,4-trisphosphate => 1D-myo-inositol 1,3,4,6-tetrakisphosphate + 1D-myo-inositol 3,4,5,6-tetrakisphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-110319", "l": "Elongation by POLH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-8986181", "l": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12472", "l": "H2O + N-ethylglycine + O2 = ethylamine + glyoxylate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31684", "l": "prosolanapyrone III => (-)-solanapyrone A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110360", "l": "Recruitment of POLB to the AP site (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42404", "l": "H2O + lactose 6-phosphate = beta-D-glucose + D-galactose 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-391168", "l": "SIRP gamma binds CD47 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46527", "l": "(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9824888", "l": "OPTN, TBK1 bind ubiquitinated MOM proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23493", "l": "UDP-alpha-D-glucosamine => UDP-alpha-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030787", "l": "inositol 4-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158849", "l": "Phenol can form a sulfate conjugate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16326", "l": "1-phospho-alpha-D-glucuronate + H(+) + UTP => diphosphate + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40886", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + FAD + H(+) <=> (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28094", "l": "di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.27", "l": "\"undecaprenyl-diphosphate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37699", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36168", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H2O => a 2'-deoxyribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78612", "l": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 15,20-dihydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696490", "l": "CRLF1:CLCF1 binds CNTRF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66734", "l": "ADP + H(+) + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + phosphate => ATP + H2O + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34360", "l": "a 1,2-diacylglycerol + H2O => a 2-acylglycerol + a carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-870479", "l": "USP9X (FAM) binds to ubiquitinated SMAD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17815", "l": "H(+) + keto-D-tagaturonate + NADH => D-altronate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11057", "l": "4-aminobenzoate + 2 H(+) + NADPH + O2 => 4-aminophenol + CO2 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60406", "l": "Fe(III)-{N-(2,3-dihydroxybenzoyl)-L-seryl-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + N-(2,3-dihydroxybenzoyl)-L-serine => Fe(III)-{di[N-(2,3-dihydroxybenzoyl)-L-seryl]-N-(C-5-[deoxy-beta-D-glucosyl]-2,3-dihydroxybenzoyl)-L-serine} + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-186780", "l": "PI3-kinase binds to the active receptor (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209376", "l": "SPN27A binds to and inhibits EA protease activity (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47009", "l": "[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide => [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "49.323585417200093", "identifiers": [{"i": "GO:0015318", "l": "inorganic molecular entity transmembrane transporter activity", "d": ["Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8864278", "l": "AP-2 (TFAP2) transcription factors form homo- and heterodimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786789", "l": "FLT3LG dimer binds FLT3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047788", "l": "2-coumarate reductase activity", "d": ["Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD+ = trans-2-coumarate + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26342", "l": "L-selenocysteine + S-methyl-L-methionine => H(+) + L-methionine + Se-methyl-L-selenocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9028730", "l": "Activated NTRK2 binds FRS2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-914008", "l": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8938815", "l": "RNF152 polyubiquitinates RRAGA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53143", "l": "N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71122", "l": "H(+) + hispidin + NADPH + O2 <=> 3-hydroxyhispidin + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74215", "l": "H2O + L-seryl-tRNA(Lys) = L-serine + tRNA(Lys)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51078", "l": "2-hydroxy-17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+) => 2-hydroxy-17beta-estradiol + 3'-phosphoadenylyl sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26444", "l": "a ubiquinol + acetaldehyde => a ubiquinone + ethanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-383190", "l": "HCO3- transport through ion channel (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200735", "l": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031928", "l": "pyridoxine transmembrane transporter activity", "d": ["Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19540", "l": "D-mannitol 1-phosphate + H2O <=> D-mannitol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73538", "l": "CDP(out) + UTP(in) <=> CDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-964970", "l": "2xPDXK:2xZn2+ phosphorylates PXL (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030784", "l": "3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72852", "l": "ADP(out) + AMP(in) => ADP(in) + AMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61139", "l": "(2R,3R)-dihydroquercetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + quercetin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13818", "l": "[protein]-disulfide + H2O + phylloquinone => 2,3-epoxyphylloquinone + [protein]-dithiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19876", "l": "dehydroepiandrosterone 3-sulfate + H2O <=> 3beta-hydroxyandrost-5-en-17-one + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9023861", "l": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204850", "l": "Interaction of Tie2 and Dok-2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9818975", "l": "CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4518585", "l": "NLK mRNA translation controlled by miR-92b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5651739", "l": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21532", "l": "ATP + glutathione + glutathionylspermidine = ADP + H(+) + phosphate + trypanothione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14222", "l": "H2O + monomethyl sulfate => H(+) + methanol + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58328", "l": "(Z)-non-6-en-1-ol + NADP(+) = (Z)-non-6-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30987", "l": "(S)-2,3-epoxysqualene = (17Z)-protosta-17(20),24-dien-3beta-ol", "d": [], "t": []}, {"i": "EC:5.4.99.32", "l": "\"protostadienol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58214", "l": "dihydroserpentine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => ajmalicine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5689950", "l": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909732", "l": "Phosphorylation of STAT2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5634104", "l": "SUMO-CRABP2:atRA translocates from cytosol to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-428052", "l": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61685", "l": "glycero-2-phosphocholine + H2O => glycerol + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-427528", "l": "Formation of energy-dependent Nucleolar Silencing Complex (eNoSC) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26257", "l": "dehydroabietadienol + H(+) + NADPH + O2 = dehydroabietadienal + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56371", "l": "3,4-dihydroxybenzoate + 2 bromide + 5 H(+) + 2 NADPH + 2 O2 <=> 3,5-dibromobenzene-1,2-diol + CO2 + 4 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-983146", "l": "Interaction of beta-2-microglobulin (B2M) chain with  class I HC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1370505", "l": "PRLR is phosphorylated at Ser-349 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034563", "l": "2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity", "d": ["Catalysis of the reaction: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + O2 = 4-hydroxyphenacyl alcohol + 4-hydroxybenzoate + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047289", "l": "galactosyldiacylglycerol alpha-2,3-sialyltransferase activity", "d": ["Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5651805", "l": "LIG1 bound to APEX1 and PCNA ligates SSB (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6808566", "l": "CHGA-derived peptide binds the bacterial cell surface (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.182", "l": "\"lipid-A-disaccharide synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0180014", "l": "protein-tRNA adaptor activity", "d": ["The binding activity of a protein that brings together another protein and a tRNA, permitting those molecules to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22106", "l": "3''-deamino-3''-oxonicotianamine + L-glutamate => 2-oxoglutarate + nicotianamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787757", "l": "PXLP-K333-GADL1 decarboxylates acidic AAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043992", "l": "histone H3K9 acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1475414", "l": "PTHP is reduced to BH4 by sepiapterin reductase (SPR) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61179", "l": "(E)-caffeoyl-CoA + quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside <=> CoA + H(+) + quercetin 3-O-[(6-O-[(E)-caffeoyl]-beta-D-glucosyl)-(1->2)-beta-D-glucoside]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046969", "l": "NAD-dependent histone H3K9 deacetylase activity", "d": ["Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein."], "t": []}, {"i": "REACT:R-HSA-9604829", "l": "SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9769235", "l": "MAGED1 binds NPAS4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-83803", "l": "Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75835", "l": "(5S)-hydroperoxy-(6E,8Z)-octadecadienoate + 2 glutathione = (5S)-hydroxy-(6E,8Z)-octadecadienoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3229089", "l": "PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209815", "l": "Tyrosine is monoiodinated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5625426", "l": "Retrograde IFT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13270", "l": "a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O => an N-acylsphing-4-enine + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67773", "l": "a 5'-end 5'-phospho-ribonucleoside-RNA + H2O => a 5'-end dephospho-ribonucleoside-RNA + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39969", "l": "2-iminobutanoate => 2-aminobut-2-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24827", "l": "(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] => dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853379", "l": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5691004", "l": "XPC binds RAD23 and CETN2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047783", "l": "corticosterone 18-monooxygenase activity", "d": ["Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-211239", "l": "Association of DFF40 with chromatin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8851538", "l": "NTPDase8 hydrolyzes nucleoside triphosphates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6806610", "l": "Keratin filament formation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1067667", "l": "IL6 binds IL6R (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57036", "l": "[(1->6)-alpha-D-glucosyl](n) + sucrose = (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9700154", "l": "Active ALK binds SHC1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5334827", "l": "SUMO-CRABP2 binds atRA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16960", "l": "3',5'-cyclic GMP + H2O <=> GMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3159253", "l": "MMAB adenosylates cob(I)alamin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218640", "l": "SRC-1 phosphorylates p-Y397-PTK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012721", "l": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851352", "l": "CCR8 binds CCL1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814554", "l": "Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19350", "l": "(R)-4-dehydropantoate + H2O + NAD(+) => (R)-3,3-dimethylmalate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035439", "l": "halimadienyl-diphosphate synthase activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate = halima-5(6),13-dien-15-yl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54366", "l": "acetoin => 2 acetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391153", "l": "p-4Y-SIRPA:CD47 binds GRB2-1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34090", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + cholesterol <=> a 1-acyl-sn-glycero-3-phosphocholine + a cholesterol ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672961", "l": "PP2A dephosphorylates inactive RAFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22500", "l": "(E)-feruloyl-CoA + H(+) + malonyl-CoA = (E)-feruloylacetyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-205328", "l": "Interaction of other tyrosine kinases with p-KIT (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-448421", "l": "Interleukin-27 translocates from the ER lumen to the extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74711", "l": "Phosphorylation of IRS (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67650", "l": "2'-deoxyadenosine + H(+) + triphosphate => dATP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30118", "l": "decanoyl-[ACP] + H2O <=> decanoate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5672954", "l": "p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76027", "l": "(S)-reticuline + 2-oxoglutarate + O2 = (S)-6-O-demethylreticuline + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59153", "l": "ATP + CoA + pseudomonate C => AMP + diphosphate + pseudomonoyl-CoA C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65627", "l": "hexadecanoyl-CoA + sphinga-(4E,8Z)-dienine <=> CoA + H(+) + N-hexadecanoylsphinga-(4E,8Z)-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-264695", "l": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-73931", "l": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5615637", "l": "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-504054", "l": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40357", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40979", "l": "1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033889", "l": "N-sulfoglucosamine-3-sulfatase activity", "d": ["Catalysis of the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517705", "l": "p-S318,221-HuR binds mRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902388", "l": "ceramide 1-phosphate transfer activity", "d": ["Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle."], "t": []}, {"i": "REACT:R-HSA-5339535", "l": "CPTP transports C1P from plasma membrane to Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18062", "l": "5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran => methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3928592", "l": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71736", "l": "formyl-CoA + succinate => formate + succinyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39824", "l": "eicosanoate + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 2-hydroxyeicosanoate + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68241", "l": "L-methionine(in) + Na(+)(in) => L-methionine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-202354", "l": "Translocation of PLC-gamma1 to PIP2 (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1483222", "l": "ETA is phosphorylated to PETA by CHK/ETNK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13400", "l": "6-oxohexanoate + H2O + NADP(+) <=> 2 H(+) + hexanedioate + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29780", "l": "ATP + H2O + L-methionine(out) => ADP + H(+) + L-methionine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62481", "l": "1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O => 2-glutaroyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052677", "l": "D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity", "d": ["Catalysis of the reaction: D-arabinitol + NADP+ = D-xylulose + NADPH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-173488", "l": "The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44957", "l": "(2E)-hexenoyl-CoA + H(+) + NADPH => hexanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57457", "l": "(E)-sinapate + UDP-alpha-D-glucose => 4-O-(beta-D-glucosyl)-trans-sinapate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75711", "l": "a rhodoquinone + succinate = a rhodoquinol + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16325", "l": "1-phospho-alpha-D-glucuronate + H(+) + UTP = diphosphate + UDP-alpha-D-glucuronate", "d": [], "t": []}, {"i": "EC:2.7.7.44", "l": "\"glucuronate-1-phosphate uridylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.6.1.61", "l": "\"diadenosine hexaphosphate hydrolase (ATP-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141422", "l": "MAD2 converted  to an inhibitory state via interaction with Mad1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9618021", "l": "FOXG1 binds FOXO:SMAD complexes (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30136", "l": "dodecanoyl-CoA + H2O => CoA + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917700", "l": "MVB Vesicle Formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37660", "l": "anthraniloyl-CoA + methanol => CoA + O-methyl anthranilate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70101", "l": "penilactone A => H(+) + o-quinone methide + peniphenone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5674387", "l": "Phosphorylated MAPKs translocate into the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-438037", "l": "Membrane depolarization upon activation of Ca impermeable AMPA receptors (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32886", "l": "(11R)-dihydroartemisinic aldehyde + NADP(+) <=> (+)-artemisinic aldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39406", "l": "(2E,19Z,22Z,25Z,28Z)-tetratriacontapentaenoyl-CoA + H(+) + NADPH <=> (19Z,22Z,25Z,28Z)-tetratriacontatetraenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-879575", "l": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47413", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA => a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804402", "l": "TP53 binds POU4F1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626507", "l": "IQGAPs bind F-actin, which is inhibited by calmodulin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35085", "l": "acetate + N'-monoacetylchitobiose-6'-phosphate => diacetylchitobiose-6'-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-8848829", "l": "CBL autoubiquitinates (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72738", "l": "UDP-N-acetyl-alpha-D-galactosamine(in) + UMP(out) <=> UDP-N-acetyl-alpha-D-galactosamine(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062145", "l": "L-propargylglycine--L-glutamate ligase activity", "d": ["Catalysis of the reaction: ATP + L-glutamate + L-propargylglycine = ADP + H+ + L-gamma-glutamyl-L-propargylglycine + phosphate."], "t": []}, {"i": "RHEA:59896", "l": "ATP + L-glutamate + L-propargylglycine = ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49017", "l": "aurachin C epoxide => 2-hydroxy-1a-methyl-7a-[(2E,6E)-farnesyl]-1a,2-dihydrooxireno[2,3-b]quinolin-7(7aH)-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102255", "l": "neo-lambda-carrahexaose hydrolase activity", "d": ["Catalysis of the reaction: neo-lambda-carrahexaose + H2O = neo-lambda-carratetraose + neo-lambda-carrabiose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65315", "l": "an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65003", "l": "holo-[ACP] + octanoyl-AMP <=> AMP + H(+) + octanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65107", "l": "aculene D + L-prolyl-[peptidyl-carrier protein] <=> aculene B + holo-[peptidyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849463", "l": "PTK6 phosphorylates SFPQ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28303", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + germacrene C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28697", "l": "hydrogencarbonate(out) => hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57656", "l": "a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1balpha + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5649701", "l": "NEIL1,NEIL2 displace OGG1 from AP-dsDNA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60079", "l": "4beta-hydroxymethyl-4alpha-methylzymosterol + H(+) + NADH + O2 <=> 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102159", "l": "baicalein 7-O-glucuronosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucuronate + baicalein = H+ + UDP + baicalin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050302", "l": "indole-3-acetaldehyde oxidase activity", "d": ["Catalysis of the reaction: (indol-3-yl)acetaldehyde + H2O + O2 = (indol-3-yl)acetate + H2O2 + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851356", "l": "NTPDase5 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16855", "l": "AMP + fumarate => N(6)-(1,2-dicarboxyethyl)-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11954", "l": "2-hydroxy-3-oxopropanoate => 3-hydroxypyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193064", "l": "HSD17B3-like proteins reducde ANDST to TEST (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77902", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-6-aminohexanoate + O2 <=> (1-deoxy-D-fructos-1-yl)amine + 6-oxohexanoate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696356", "l": "OSCAR binds collagen and SP-D (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9843721", "l": "ABCC1,ABCG2 transport C18-S1P to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30553", "l": "6-O-acetyl-beta-D-glucose + CoA => acetyl-CoA + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811418", "l": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685649", "l": "SFTPAs translocate from ER membrane to extracellular region (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33427", "l": "(S)-malyl alpha-D-glucosaminide + L-cysteine = bacillithiol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5252079", "l": "HSP110s exchange ATP for ADP on HSP70s:ADP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15013", "l": "3alpha(S)-strictosidine + H2O = secologanin + tryptamine", "d": [], "t": []}, {"i": "EC:4.3.3.2", "l": "\"strictosidine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23608", "l": "H(+) + H2O + N-isopropylammelide = cyanurate + isopropylamine", "d": [], "t": []}, {"i": "EC:3.5.4.42", "l": "\"N-isopropylammelide isopropylaminohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38711", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecylglycerol = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-3-(9Z)-octadecenoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6809707", "l": "MTMR12 binds MTMR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-214956", "l": "Full-length EA is cleaved by SNK serine protease (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855193", "l": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63945", "l": "a fatty acyl-CoA + sphinga-4E,14Z-dienine => an N-acyl-sphinga-4E,14Z-dienine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-517536", "l": "N-arachidonyl glycine receptor GPR18 binds N-arachidonyl glycine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69597", "l": "AMP + inosine => adenosine + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-353125", "l": "26S proteosome degrades ODC holoenzyme complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444859", "l": "Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69780", "l": "2-oxindole-3-acetate + succinyl-CoA => (2-oxoindol-3-yl)acetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5682020", "l": "MRN complex binds shortened telomeres (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-68947", "l": "Ubiquitinated Orc1 enters the cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16961", "l": "epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine", "d": [], "t": []}, {"i": "EC:4.3.2.8", "l": "\"gamma-glutamylamine cyclotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5638141", "l": "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-351901", "l": "Caspase-mediated cleavage of MST3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27954", "l": "(2E,6E)-farnesyl diphosphate + H2O = diphosphate + presilphiperfolan-8beta-ol", "d": [], "t": []}, {"i": "EC:4.2.3.74", "l": "\"presilphiperfolanol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2534365", "l": "Slo3 Potassium Transport (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10767", "l": "(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 <=> (4S)-2,3-dehydroleucocyanidin + CO2 + H(+) + H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21971", "l": "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate <=> 3-dehydroquinate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-382061", "l": "Extracellular processing of novel PDGFs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811479", "l": "ING2 recruits EP300 to TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5679266", "l": "Beclin-1 complex translocates to the ER (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.158", "l": "\"alpha-agarase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57884", "l": "diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate", "d": [], "t": []}, {"i": "EC:7.2.3.1", "l": "\"Na(+)-exporting diphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6791221", "l": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71011", "l": "L-isoleucine(in) + L-phenylalanine(out) = L-isoleucine(out) + L-phenylalanine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63114", "l": "AH2 + ascofuranone => A + ascofuranol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036222", "l": "XTP diphosphatase activity", "d": ["Catalysis of the reaction: XTP + H2O = XMP + H+ + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29513", "l": "(+)-valencene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-186798", "l": "GAP binds to PDGF-beta receptors only (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70330", "l": "(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) <=> 4-methylsulfanyl-2-oxobutanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1168644", "l": "CARMA1 recruits MALT1 and BCL10 forming CBM Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033568", "l": "lactoferrin receptor activity", "d": ["Combining with lactoferrin and delivering lactoferrin into the cell via endocytosis. Lactoferrin is an iron-binding glycoprotein which binds ferric iron most efficiently at low pH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36600", "l": "hydrogen sulfide + NAD(+) => NADH + sulfur", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45036", "l": "3 Fe(III)-[cytochrome c] + hydroxylamine = 3 Fe(II)-[cytochrome c] + 3 H(+) + nitric oxide", "d": [], "t": []}, {"i": "EC:1.7.2.9", "l": "\"hydroxylamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48330", "l": "a III(4)-a-Fuc-Lc4Cer(d18:1(4E)) + GDP + H(+) => a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + GDP-beta-L-fucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1566981", "l": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851145", "l": "Translation of DNMT1 mRNA is repressed by miR-21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11263", "l": "H(+) + NADPH + O2 <=> H2O2 + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5339524", "l": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37198", "l": "octadecanoyl-CoA + sn-glycerol 3-phosphate <=> 1-octadecanoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482654", "l": "2-MAG is transacylated to DAG by PNPLA2/3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855230", "l": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24077", "l": "a 3beta-hydroxy-Delta(5)-steroid + NAD(+) => a 3-oxo-Delta(5)-steroid + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8868660", "l": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14404", "l": "chlordecone alcohol + NADP(+) <=> chlordecone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60301", "l": "N(6)-methyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-methionine => H(+) + N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0150043", "l": "structural constituent of synapse-associated extracellular matrix", "d": ["The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32713", "l": "a 3-oxoacyl-CoA + H(+) + NADH => a (3R)-3-hydroxyacyl-CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10037", "l": "4-hydroxy-3-methoxy-benzenemethanol + O2 => H2O2 + vanillin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9707683", "l": "PGRMC2 binds Hemes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21856", "l": "cyclohexa-1,5-diene-1-carbonyl-CoA + H2O = 6-hydroxycyclohex-1-ene-1-carbonyl-CoA", "d": [], "t": []}, {"i": "EC:4.2.1.100", "l": "\"cyclohexa-1,5-dienecarbonyl-CoA hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35403", "l": "(3R,4R)-7,2'-dihydroxy-4'-methoxyisoflavanol + NADP(+) = (3R)-vestitone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76854", "l": "(S)-sec-butylamine + H2O + NAD(+) <=> butan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70685", "l": "(R)-metanephrine + H(+) + S-adenosyl-L-homocysteine => (R)-normetanephrine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65100", "l": "a 1-acylglycerol + hexadecanoyl-CoA = an hexadecanoyl-acylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675961", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5223305", "l": "ABCE1 binds RNASEL, inhibiting it (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18211", "l": "(2S,4R)-bornyl diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8867754", "l": "F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63856", "l": "O2 + tetradecanoate = (2R)-2-hydroperoxytetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18652", "l": "D-galactonate <=> 2-dehydro-3-deoxy-D-galactonate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842669", "l": "Active LTK recruits GRB2:SOS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-434700", "l": "STIM1 activation of CRAC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-399933", "l": "Sema3A binds Nrp-1 bound to PlexinA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21334", "l": "CoA + H(+) + N-acetyl-D-glucosamine => acetyl-CoA + D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6809707", "l": "MTMR12 binds MTMR2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51196", "l": "chloride(out) + Na(+)(out) + serotonin(out) = chloride(in) + Na(+)(in) + serotonin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6781824", "l": "Active RNA Pol II complex transcribes lesion-containing DNA template (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1022133", "l": "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483174", "l": "PE is methylated to PC by PEMT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "76.745825357329565", "identifiers": [{"i": "GO:0046912", "l": "acyltransferase activity, acyl groups converted into alkyl on transfer", "d": ["Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer."], "t": []}, {"i": "EC:2.3.3.-", "l": "\"Acyl groups converted into alkyl groups on transfer\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-880050", "l": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16243", "l": "a ribonucleoside 5'-diphosphate + H(+) + sucrose => an NDP-alpha-D-glucose + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9835944", "l": "ADAR1 binds PKR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114542", "l": "RAC1,RAC2,RHOG activate PI3K (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015191", "l": "L-methionine transmembrane transporter activity", "d": ["Enables the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21045", "l": "24-methylidenelophenol + S-adenosyl-L-methionine => (Z)-24-ethylidenelophenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201783", "l": "Inactive catalytic PP2B is activated by the binding of calmodulin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48662", "l": "8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42344", "l": "H(+) + NADH + O2 + p-cumate = (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.12.25", "l": "\"p-cumate 2,3-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-4341025", "l": "SUMOylation of NR3C1 (GR) with SUMO1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619668", "l": "L-PRX:DRP:DGC:laminin-211 interacts with UTRN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33394", "l": "C20 sphinganine 1-phosphate + H2O <=> C20 sphinganine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29400", "l": "H2O + ITP => diphosphate + H(+) + IMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5423678", "l": "CYP1A2 hydroxylates AFB1 to AFM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050659", "l": "N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity", "d": ["Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-141429", "l": "Inactivation of APC/C via CDC20 sequestration (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23439", "l": "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O <=> 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9707505", "l": "Hemes bind to CLEC1B dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-983422", "l": "Disassembly of COPII coated vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8867667", "l": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24602", "l": "H2O2 + sulfate => H2O + O2 + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158300", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20619", "l": "H(+) + H2O2 + L-ascorbate => L-galactono-1,4-lactone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20755", "l": "A + 2 cob(II)alamin + 2 H(+) + 2 H2O <=> AH2 + 2 aquacob(III)alamin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-193792", "l": "CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043842", "l": "Kdo transferase activity", "d": ["Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66629", "l": "(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 => (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9664862", "l": "ATM dimer:PEX5 phosphorylates PEX5 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63893", "l": "ATP + H2O + L-tryptophan => AMP + D-tryptophan + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052680", "l": "epi-isozizaene synthase activity", "d": ["Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8942208", "l": "ALOXE3 isomerises 12R-HpETE to HXA3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54023", "l": "L-lysyl-[protein] + propanoyl-CoA <=> CoA + H(+) + N(6)-propanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1225947", "l": "Binding of SHC1 to p-6Y-EGFR mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23018", "l": "(2R,3R)-dihydrokaempferol + H(+) + NADPH => (2R,3S,4S)-3,4-leucopelargonidin + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63142", "l": "taurine + tetracosanoate => H2O + N-tetracosanoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10057", "l": "(3S)-3-aminobutanoyl-CoA => (2E)-butenoyl-CoA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15825", "l": "AZD1979 + H2O = AZD1979 oxetane hydrolysis product + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034797", "l": "fosfomycin 2-glutathione ligase activity", "d": ["Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + glutathione = hydrogen (1R,2R)-1-glutathio-2-hydroxypropylphosphonic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043917", "l": "ribose 1,5-bisphosphate isomerase activity", "d": ["Catalysis of the reaction: D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9793679", "l": "LUBAC ubiquitinates RIPK1 at K627 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-159757", "l": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8847534", "l": "RAB43 hydrolyses GTP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76232", "l": "2-oxoglutarate(in) => 2-oxoglutarate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3364014", "l": "Recruitment of SET1 methyltransferase complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2160492", "l": "IL4I1:FAD oxidises L-Phe to kPPV (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-216757", "l": "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9029667", "l": "DFF dissociates from importin-alpha:importin-beta (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61672", "l": "ATP + H(+) + L-cysteine = diphosphate + L-cysteinyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10071", "l": "4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose <=> 4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9828717", "l": "G mRNA is translated into nascent secreted G protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15499", "l": "1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine => 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31272", "l": "1-hydroxy-2-naphthoate + 2 H(+) + NADH + O2 => CO2 + H2O + NAD(+) + naphthalene-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49232", "l": "D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannose 6-phosphate(in) + L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.191", "l": "\"protein-N(pi)-phosphohistidine--D-mannose phosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48122", "l": "a ganglioside GM3 + N-acetylneuraminate => a ganglioside GD3 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2534346", "l": "SPAM1 Binds Hyaluronic Acid (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5218813", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198295", "l": "TRKA phosphorylates IRS (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52988", "l": "[deoxyhypusine synthase]-L-lysine + dehydrospermidine = [deoxyhypusine synthase]-N-(4-aminobutylidene)-L-lysine + propane-1,3-diamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9824892", "l": "MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria  (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13777", "l": "ATP + D-ribose 5-phosphate + NH4(+) = 5-phospho-beta-D-ribosylamine + ADP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:6.3.4.7", "l": "\"ribose-5-phosphate--ammonia ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373747", "l": "Phosphorylation of nephrin by FYN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1606324", "l": "Recruitment TBK1 to dsDNA:ZBP1 followed by its activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-112034", "l": "PNP catalyzes the conversion of guanine and (deoxy)ribose to (deoxy)guanosine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-194718", "l": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2161899", "l": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3108203", "l": "PRC1 SUMOylates CTBP1 with SUMO2,3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21482", "l": "5-hydroxy-2-furoyl-CoA + AH2 + H(+) => 2-furoyl-CoA + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25404", "l": "(S)-2-ethyl-2-hydroxy-3-oxobutanoate = (R)-3-hydroxy-3-methyl-2-oxopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54248", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-400092", "l": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68401", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + gamma-gurjunene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051407", "l": "glycerone phosphate:phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-68610", "l": "Formation of ORC(2-5) complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1971482", "l": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2395869", "l": "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5632652", "l": "Hh-Npp binds CDON and PTCH (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76021", "l": "18-hydroxycortisol + H2O + 2 oxidized [adrenodoxin] => cortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59564", "l": "H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone = H(+) + N,N',N'',N'''-tetraacetylchitotetraonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5683930", "l": "WICH phosphorylates H2AFX on Y142 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28690", "l": "(S)-dihydroorotate + ubiquinone-8 <=> orotate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-744231", "l": "SLC35D2 exchanges UDP-GlcNAc for UMP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75358", "l": "H2O + L-mimosine <=> 3-hydroxy-4H-pyrid-4-one + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44850", "l": "CoA + O-(9Z)-tetradecenoyl-(R)-carnitine => (9Z)-tetradecenoyl-CoA + (R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19695", "l": "5-hydroxy-6-methylpyridine-3,4-dicarboxylate + 2 H(+) + NADH => 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114558", "l": "Thrombin-activated PARs activate Gq (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71074", "l": "L-arginine(in) + L-cysteine(out) <=> L-arginine(out) + L-cysteine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-351863", "l": "Translocation of active caspase-8 to the mitochondrial membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.97.1.6", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5635855", "l": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28789", "l": "4-(phosphooxy)-L-threonine + ADP + H(+) => 4-hydroxy-L-threonine + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51989", "l": "(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O => 18S-resolvin E1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2328037", "l": "Fibrillin-1 binds integrins (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3341397", "l": "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102892", "l": "betanidin 5-O-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-alpha-D-glucose + betanidin = H+ + betanin + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-190385", "l": "Autocatalytic phosphorylation of FGFR3b (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9018862", "l": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77301", "l": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58298", "l": "25-substituted-cholesteryl beta-D-glucoside + N-hexadecanoylsphing-4-enine => 25-substituted-cholesterol + beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031926", "l": "pyridoxal phosphate transmembrane transporter activity", "d": ["Enables the transfer of pyridoxal phosphate from one side of a membrane to the other. Pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0050307", "l": "sucrose-phosphate phosphatase activity", "d": ["Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47557", "l": "H2O + taurodeoxycholate => deoxycholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202721", "l": "JAM2 binds JAM3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200711", "l": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421439", "l": "4 porphobilinogen + H2O => hydroxymethylbilane + 4 NH3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45028", "l": "(2S)-methylsuccinyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 2-methylfumaryl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.3.8.12", "l": "\"(2S)-methylsuccinyl-CoA dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0048248", "l": "CXCR3 chemokine receptor binding", "d": ["Binding to a CXCR3 chemokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-158800", "l": "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59619", "l": "beta-alanyl-L-arginine + H2O <=> beta-alanine + L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21008", "l": "diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.229", "l": "\"diethyl 2-methyl-3-oxosuccinate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9605051", "l": "Expression of PCK1 regulated by NR1H3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-555065", "l": "Formation of clathrin coated vesicle (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015066", "l": "alpha-amylase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of alpha-amylase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77327", "l": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.2", "l": "\"pyrroline-5-carboxylate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29859", "l": "5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40567", "l": "AH2 + dTDP-2,3,6-trideoxy-3-C-methyl-4-O-methyl-3-nitroso-beta-L-arabino-hexopyranose + O2 = A + dTDP-beta-L-evernitrose + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41950", "l": "[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH => [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20340", "l": "(R)-2-O-sulfolactate + H2O <=> (R)-lactate + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60947", "l": "quercetin + S-adenosyl-L-methionine <=> H(+) + isorhamnetin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20500", "l": "a 2-arylethylamine + acetyl-CoA <=> an N-acetyl-2-arylethylamine + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54120", "l": "coelenterazine h + O2 = coelenterazine h dioxetanone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60520", "l": "2 H2O + L-cystine-bis-glycine = 2 glycine + L-cystine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909730", "l": "Phosphorylation of INFAR1 by TYK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-392051", "l": "Recruitment of Grb2 to pFAK:NCAM1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.16.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001222", "l": "transcription corepressor binding", "d": ["Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3000074", "l": "TCN2 binds RCbl in the circulation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2467775", "l": "Autocleavage of ESPL1 (Separase) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-170161", "l": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855176", "l": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39425", "l": "(2E,23Z,26Z,29Z,32Z)-octatriacontapentaenoyl-CoA + H2O => (3R)-hydroxy-(23Z,26Z,29Z,32Z)-octatriacontatetraenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68205", "l": "1,2-dihexanoylglycerol + octadecanoyl-CoA => 1,2-dihexanoyl-3-octadecanoylglycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6783483", "l": "tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429497", "l": "SLP-76 stimulates PLC gamma 2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58535", "l": "15alpha-stemmadenine intermediate I + H2O <=> akuammicine + formate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8867658", "l": "PTPN3 dephosphorylates MAPK12 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3900177", "l": "SUMOylation of DDX5 with SUMO1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55936", "l": "all-trans-4-hydroxyretinol + NAD(+) = all-trans-4-hydroxyretinal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36630", "l": "2-hydroxytetracosanoyl-CoA + sphinganine <=> CoA + H(+) + N-(2-hydroxytetracosanoyl)-sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428752", "l": "Dissociation of the TP:Gq complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28837", "l": "citrate(in) + succinate(out) => citrate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58702", "l": "FADH2 + H(+) + H2O + NADP(+) + rifampicin hemiaminal => FADH2-C4alpha-hydroperoxide + NADPH + rifampicin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32355", "l": "delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + 2 UDP-alpha-D-glucose = 2 H(+) + ternatin C5 + 2 UDP", "d": [], "t": []}, {"i": "EC:2.4.1.249", "l": "\"delphinidin 3',5'-O-glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25840", "l": "5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate", "d": [], "t": []}, {"i": "EC:5.3.1.30", "l": "\"5-deoxy-glucuronate isomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46182", "l": "2-methylbutanoyl-CoA + AMP + diphosphate => 2-methylbutanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944230", "l": "Association of procollagen type XVIII (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28162", "l": "cytidine + GTP = CMP + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987220", "l": "IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12963", "l": "acetoacetyl-CoA + butanoate => acetoacetate + butanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68220", "l": "(7Z,10Z,13Z)-hexadecatrienoyl-CoA + phytol = (7Z,10Z,13Z)-hexadecatrienoate phytyl ester + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-196086", "l": "Cholesterol translocates from mitochondrial intermembrane space to inner mitochondrial membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77756", "l": "(4E,11E)-2-hydroxytrideca-4,11-dien-1,2,3-tricarboxylate + 2 H(+) => [4-(deca-1,8-diyl)-2,5-dioxo-2,5-dihydro-3-furanyl]acetate + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30376", "l": "(2E,6E)-farnesyl diphosphate => (+)-thujopsene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59973", "l": "decanoyl-CoA + L-seryl-[protein] => CoA + O-decanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25795", "l": "ATP + Cu(+)(in) + H2O <=> ADP + Cu(+)(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73250", "l": "ladanein + S-adenosyl-L-methionine <=> H(+) + S-adenosyl-L-homocysteine + salvigenin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5618073", "l": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762209", "l": "BACH1 is phosphorylated at tyrosine 483 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-265153", "l": "Proinsulin:Zinc:Calcium complex translocates to immature secretory granule (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.4", "l": "\"N-acetylgalactosamine-6-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49281", "l": "FADH2 + O2 + phenol => catechol + FAD + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70033", "l": "castasterone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] => 6-deoxocastasterone + 2 O2 + 2 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199863", "l": "AKT can phosphorylate NR4A1 (NUR77) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35533", "l": "albonoursin + 2 H2O2 => cyclo(L-phenylalanyl-L-leucyl) + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74668", "l": "(6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate => (2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39954", "l": "(9Z)-octadecenoyl-CoA + 2-(9Z-octadecenoyl)-glycerol <=> 1,2-di-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33708", "l": "ATP + L-threonine => ADP + H(+) + O-phospho-L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20337", "l": "(R)-2-O-sulfolactate + H2O = (R)-lactate + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.17", "l": "\"D-lactate-2-sulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41487", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine <=> 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73616", "l": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200406", "l": "CPT1A,B transfers PALM to CAR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1008248", "l": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69564", "l": "12 ATP + L-asparagine + L-aspartate + L-cysteine + L-glutamate + L-histidine + 3 L-isoleucine + L-leucine + L-lysine + L-ornithine + L-phenylalanine = 12 AMP + bacitracin A + 12 diphosphate + 12 H(+) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52540", "l": "cytidine + phosphate = alpha-D-ribose 1-phosphate + cytosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43468", "l": "(8Z,11Z,14Z)-eicosatrienoate + O2 = (8Z,10E,14Z)-12-hydroperoxyeicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62331", "l": "(+)-isomalbrancheamide B + chloride + FAD + 2 H(+) <=> (+)-malbrancheamide + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-203662", "l": "eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13926", "l": "(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine => holo-[ACP] + UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44073", "l": "1-O-alkyl-2-acyl-sn-glycerol + ATP => 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9026003", "l": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67814", "l": "a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP] => a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-388596", "l": "Melanocortin receptors bind melanocortins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43862", "l": "1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out) => 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6804441", "l": "RNF34 or RFFL ubiquitinates phosphorylated TP53 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9734540", "l": "ACLY tetramer binds ETC-1002-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0047101", "l": "branched-chain alpha-keto acid dehydrogenase activity", "d": ["Catalysis of the reaction: [a branched-chain alpha-keto acid] + CoA + NAD+ = [a branched-chain acyl-CoA] + CO2 + NADH. This enzyme system catalyzes the oxidative decarboxylation of branched-chain alpha-keto acids derived from L-leucine, L-isoleucine, and L-valine to branched-chain acyl-CoAs."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48429", "l": "1-(9Z,12Z-octadecadienoyl)-glycerol + H2O => (9Z,12Z)-octadecadienoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14933", "l": "H2O + N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] = N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015375", "l": "glycine:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170055", "l": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396561", "l": "Recruitment of GADS:SLP-76 to p-5Y-LAT (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44688", "l": "a 2-acylglycerol + H2O = a fatty acid + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5617828", "l": "TRIP11:IFT20 dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16202", "l": "4-amino-4-deoxychorismate => 4-aminobenzoate + H(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52371", "l": "3'-phosphoadenylyl sulfate + cholesterol <=> adenosine 3',5'-bisphosphate + cholesterol sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9684627", "l": "CYSLTR1 binds CYSLTR1 antagonists (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1482626", "l": "2-acyl LPI is acylated to PI by MBOAT7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.3", "l": "\"lysine carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59958", "l": "a nitrile + sulfate + sulfur => a (Z)-N-(sulfonatooxy)alkanimidothioate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5423664", "l": "CYP3A4,5 hydroxylates AFB1 to AFQ1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-432237", "l": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36665", "l": "(2S,5S)-5-carboxymethylproline + CO2 + CoA => (S)-1-pyrroline-5-carboxylate + H(+) + H2O + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36918", "l": "(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(17Z,20Z,23Z,26Z)-dotriacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8939204", "l": "ESTG binds ESR1:chaperone complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4724284", "l": "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35436", "l": "cyanidin 3-O-beta-D-galactoside + UDP-alpha-D-xylose => cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70899", "l": "histidine => urocanate + NH4+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-354173", "l": "Activation of Rap1 by cytosolic GEFs (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36910", "l": "(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA + H(+) + malonyl-CoA <=> (13Z,16Z,19Z,22Z)-3-oxooctacosatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-429860", "l": "DCP1-DCP2 complex decaps mRNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-139905", "l": "Translocation of activated BAD protein to mitochondria (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21364", "l": "H2O + N-(6-aminohexanoyl)-6-aminohexanoate = 2 6-aminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19376", "l": "H2O + L-saccharopine + NADP(+) <=> 2-oxoglutarate + H(+) + L-lysine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19234", "l": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] => H(+) + hexadecanoate + L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12089", "l": "an N-acylsphing-4-enine + UDP-alpha-D-glucose => a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1237059", "l": "CA4:Zn2+ dehydrates HCO3- to CO2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.226", "l": "\"N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59174", "l": "AMP + H(+) + hexadecanoyl-[(hydroxy)phthioceranic acid synthase] => hexadecanoyl-AMP + holo-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-265426", "l": "Interaction of integrin alphaVbeta3 with Tenascin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0034069", "l": "aminoglycoside N-acetyltransferase activity", "d": ["Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6814153", "l": "ADO oxidises 2AET to HTAU (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35084", "l": "diacetylchitobiose-6'-phosphate + H2O => acetate + N'-monoacetylchitobiose-6'-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21033", "l": "glucuronate acceptor + UDP-alpha-D-glucuronate => acceptor beta-D-glucuronoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31012", "l": "(S)-2,3-epoxysqualene => camelliol C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174367", "l": "GCL ligates L-Glu to L-Cys (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-917891", "l": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0062065", "l": "box H/ACA snoRNP complex binding", "d": ["Binding to a box H/ACA snoRNP complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25025", "l": "H(+) + H2O + S-methyl-5'-thioadenosine = NH4(+) + S-methyl-5'-thioinosine", "d": [], "t": []}, {"i": "EC:3.5.4.31", "l": "\"S-methyl-5'-thioadenosine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8948234", "l": "P4HB:4-Hyp collagen propeptides dissociates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836617", "l": "p-PKR dimer phosphorylates SPHK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.16", "l": "\"membrane Pro-Xaa carboxypeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036470", "l": "tyrosine 3-monooxygenase activator activity", "d": ["Binds to and increases the activity of tyrosine 3-monooxygenase (tyrosine hydroxylase)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70234", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) <=> (S)-2-benzoylsuccinyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34144", "l": "cannabinerolate + O2 => Delta(9)-tetrahydrocannabinolate + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9679044", "l": "FKBP1A binds sirolimus (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74252", "l": "1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5358597", "l": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5678261", "l": "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602484", "l": "Activation of proMMP11 by FURIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50244", "l": "17alpha-hydroxypregnenolone + O2 + reduced [NADPH--hemoprotein reductase] = 3beta-hydroxyandrost-5-en-17-one + acetate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28132", "l": "baicalein + D-glucuronate + H(+) => baicalin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64827", "l": "1-naphthaleneacetamide + H2O <=> 1-naphthaleneacetate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029475", "l": "Production of AA by iPLA2 upon FCGR activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-879585", "l": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9708423", "l": "XPO1:BACH1:Hemes are transported out of the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48271", "l": "4',4'-dihydroxyechinenone <=> canthaxanthin + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45132", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+) + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70471", "l": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003953", "l": "NAD+ nucleosidase activity", "d": ["Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15163", "l": "H2O + homogentisate + NAD(+) => 4-hydroxyphenylacetate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-391168", "l": "SIRP gamma binds CD47 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-912727", "l": "CBL binds VAV (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48690", "l": "D-alanine + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl => H2O + N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46435", "l": "(25R)-4beta,26-dihydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63971", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) <=> atromentin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-165028", "l": "Release of the HIV mRNA and Crm1 from Rev in the cytoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051498", "l": "syn-copalyl diphosphate synthase activity", "d": ["Catalysis of the reaction: geranylgeranyl diphosphate = 9alpha-copalyl diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5675947", "l": "TNFSF18 binds TNFRSF18 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76943", "l": "3-aminohexane + H2O + NADP(+) = H(+) + hexan-3-one + NADPH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64065", "l": "(1R,2R)-pseudoephedrine + NAD(+) => (R)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-192430", "l": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46394", "l": "4beta,24S-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2466085", "l": "at-retinyl is hydrolysed from R* to release atRAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855177", "l": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199935", "l": "MSK1 activates CREB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74376", "l": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9654523", "l": "ARL2:GTP bind PDE6D on KRAS4B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16953", "l": "2-oxoglutarate + N(2)-succinyl-L-ornithine = L-glutamate + N-succinyl-L-glutamate 5-semialdehyde", "d": [], "t": []}, {"i": "EC:2.6.1.81", "l": "\"succinylornithine transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10130", "l": "all-trans-neoxanthin => all-trans-violaxanthin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9648983", "l": "HTR3A pentamer:5HT transports Na+,K+,Ca2+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6783221", "l": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8858252", "l": "HDLBP binds HDL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31740", "l": "a 4'-hydroxyisoflavone + S-adenosyl-L-methionine => a 4'-methoxyisoflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44862", "l": "CoA + O-4,8-dimethylnonanoyl-(R)-carnitine => (R)-carnitine + 4,8-dimethylnonanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202291", "l": "Activation of Lck (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2424477", "l": "SOS mediated nucleotide exchange of RAS (SHC) (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-374909", "l": "Catabolism of Noradrenaline (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54576", "l": "2-oxoglutarate + an N(1)-methyladenosine in tRNA + O2 = an adenosine in tRNA + CO2 + formaldehyde + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78478", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine <=> a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21262", "l": "[thioredoxin]-dithiol + L-methionine (R)-S-oxide => [thioredoxin]-disulfide + H2O + L-methionine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17630", "l": "alpha,alpha-trehalose(in) => alpha,alpha-trehalose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68249", "l": "L-tyrosine(in) + Na(+)(in) => L-tyrosine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380608", "l": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39565", "l": "(23Z,26Z,29Z,32Z,35Z)-octatriacontapentaenoyl-CoA + NADP(+) => (2E,23Z,26Z,29Z,32Z,35Z)-octatriacontahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051268", "l": "alpha-keto amide reductase activity", "d": ["Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9018863", "l": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1031716", "l": "Expression of IFNG-stimulated genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5685607", "l": "Sialic acid binds SIGLEC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-173720", "l": "C5b:C6:C7 translocates to the plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41552", "l": "(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = diphosphate + ophiobolin F", "d": [], "t": []}, {"i": "EC:4.2.3.145", "l": "\"ophiobolin F synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961895", "l": "CCNA1 gene expression is stimulated by E2F1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56868", "l": "(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA = (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA", "d": [], "t": []}, {"i": "EC:2.3.1.273", "l": "\"diglucosylglycerate octanoyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58678", "l": "H2O + NADP(+) + rifamycin SV para-naphthoquinone carboxamide => NADPH + O2 + rifamycin SV", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56572", "l": "a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose = a globoside Gb3Cer + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16161", "l": "2 Fe(III)-[leghemoglobin] + NADH = 2 Fe(II)-[leghemoglobin] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71154", "l": "4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one <=> (E)-caffeoylpyruvate + CO2 + hnu", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17813", "l": "D-altronate + NAD(+) = H(+) + keto-D-tagaturonate + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.58", "l": "\"tagaturonate reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70692", "l": "ornithine => putrescine + CO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6785933", "l": "UGT8 transfers Gal from UDP-Gal to CERA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29082", "l": "(R)-lactate + ubiquinone-8 <=> pyruvate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43622", "l": "aminoacetaldehyde + CO2 + NADPH => L-serine + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-349637", "l": "spherical HDL and SR-BI receptor form a complex at the cell surface (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-418309", "l": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5334179", "l": "DNMT3A:DNMT3L binds chromatin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64222", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + taurine => H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58334", "l": "(E)-non-2-enal + H(+) + NADPH => (E)-non-2-en-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10530", "l": "10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32275", "l": "4-(phosphooxy)-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO2 + NADH", "d": [], "t": []}, {"i": "EC:1.1.1.262", "l": "\"4-hydroxythreonine-4-phosphate dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59920", "l": "(2E)-octenal + H2O + NAD(+) = (2E)-octenoate + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49995", "l": "H(+) + NADH + O2 + propane <=> H2O + NAD(+) + propan-2-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77283", "l": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73373", "l": "(R)-pantothenate(in) + 2 Na(+)(in) => (R)-pantothenate(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78984", "l": "(2E,6E,10E)-geranylgeranyl diphosphate => allokutznerene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2213207", "l": "Formation of collagen networks (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5693542", "l": "Association of RPA complexes with ssDNA at resected DNA DSBs (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.923250621671642", "identifiers": [{"i": "GO:0052742", "l": "phosphatidylinositol kinase activity", "d": ["Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate."], "t": []}, {"i": "REACT:R-HSA-1675773", "l": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33405", "l": "diphosphate + L-threonyl-5'-AMP => ATP + L-threonine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40527", "l": "2 a ubiquinol + 4 H(+)(in) + O2(in) = 2 a ubiquinone + 4 H(+)(out) + 2 H2O(in)", "d": [], "t": []}, {"i": "EC:7.1.1.7", "l": "\"ubiquinol oxidase (electrogenic, proton-motive force generating)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21950", "l": "formate + NH4(+) => formamide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031772", "l": "type 2 orexin receptor binding", "d": ["Binding to a type 2 orexin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9011941", "l": "Estrogen-responsive BCL2 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-448678", "l": "CTSG cleaves CASP1(1-404) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40329", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-376364", "l": "Vamp8 associated secretory vesicle to plasma membrane transport (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6795290", "l": "TORC2 complex phosphorylates SGK1 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48593", "l": "a quinone + formate + H(+) => a quinol + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3215385", "l": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61889", "l": "diosgenin + UDP-alpha-D-glucose => diosgenin 3-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41729", "l": "(9Z)-octadecenoate + O2 + reduced [NADPH--hemoprotein reductase] => 18-hydroxy-(9Z)-octadecenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74740", "l": "Binding of SHC1 to insulin receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73767", "l": "cyclo(L-tryptophyl-L-alanyl) + dimethylallyl diphosphate = diphosphate + preechinulin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9013023", "l": "RHOB GEFs activate RHOB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.128", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78746", "l": "H2O + ipecoside <=> D-glucose + ipecoside aglycone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13370", "l": "dimethylallyl diphosphate => diphosphate + isoprene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52097", "l": "9-octadecanoyloxy-octadecanoate + H2O => 9-hydroxy-octadecanoate + H(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051777", "l": "ent-kaurenoic acid monooxygenase activity", "d": ["Catalysis of the reaction:ent-kaur-16-en-19-oate + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = gibberellin A12 + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. Catalyzes three successive oxidations of ent-kaurenoic acid."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75329", "l": "chloride(in) + D-tryptophan(in) + 2 Na(+)(in) => chloride(out) + D-tryptophan(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917730", "l": "Cargo Recognition And Sorting (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18090", "l": "H2O + L-arginyl-[protein] => L-citrullyl-[protein] + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34338", "l": "cholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> (22R)-hydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5691176", "l": "NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66614", "l": "methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] => N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18999", "l": "CDP-choline + diphosphate => CTP + H(+) + phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73566", "l": "dGDP(out) + UTP(in) <=> dGDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49394", "l": "20S,23,24-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin] => 20S,23-dihydroxycholecalciferol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47267", "l": "2,6,10,14-tetramethylpentadecanoate + ATP + CoA <=> AMP + diphosphate + pristanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13754", "l": "2 L-glutamate + NAD(+) => 2-oxoglutarate + H(+) + L-glutamine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56263", "l": "N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP-alpha-D-galactose <=> 4 H(+) + N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 4 UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15368", "l": "3-O-[(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + UDP-alpha-D-xylose <=> 3-O-[beta-D-xylosyl-(1->4)-(D-ribitylphospho)2-3-N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-O-6-phospho-alpha-D-mannosyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9650473", "l": "SERPING1 is secreted (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72082", "l": "3 Na(+)(out) + selenate(out) <=> 3 Na(+)(in) + selenate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76859", "l": "3-aminopentane + H2O + NAD(+) = H(+) + NADH + NH4(+) + pentan-3-one", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8987218", "l": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-354165", "l": "Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626938", "l": "Beta-catenin binds SOX proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30485", "l": "H(+) + H2O + N,N-dihydroxy-L-isoleucine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-isoleucine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42831", "l": "2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.3.n14", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674093", "l": "PDGFRs bind type I TKI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5686625", "l": "LAIR1 binds collagen (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54109", "l": "(2E,6E)-farnesyl diphosphate => diphosphate + guaia-4,6-diene", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17761", "l": "an aromatic primary alcohol + NADP(+) = an aromatic aldehyde + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.91", "l": "\"aryl-alcohol dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004805", "l": "trehalose-phosphatase activity", "d": ["Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2730864", "l": "Recruitment of TRAF6 to CBM complex by binding to MALT1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56617", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene => 1,2,4-trichlorobenzene + chloride + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45913", "l": "a (2E,4E)-dienoyl-CoA + H(+) + NADPH => a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73057", "l": "estrone 3-sulfate(in) + hydrogencarbonate(out) => estrone 3-sulfate(out) + hydrogencarbonate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2997616", "l": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69067", "l": "N(delta),N(omega')-dihydroxy-N(omega)-methyl-L-arginine + O2 <=> H2O + N(delta)-hydroxy-N(omega)-methyl-N(omega)-nitroso-L-citrulline", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8854173", "l": "TBC RabGAPs accelerate GTP hydrolysis by RAB35 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-210805", "l": "Removal of miRNA passenger strand (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6802943", "l": "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8942836", "l": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8985943", "l": "p-Y701-STAT1 dimerizes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15536", "l": "(2R)-3-sulfolactate + NAD(+) <=> 3-sulfopyruvate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-548815", "l": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28860", "l": "Ag(+)(in) + H(+)(in) => Ag(+)(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51358", "l": "(9Z)-octadecenoate + L-glutamine => H2O + N-(9Z-octadecenoyl)-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56357", "l": "3-bromo-4-hydroxybenzoate + bromide + 3 H(+) + NADPH + O2 => 2,4-dibromophenol + CO2 + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3780994", "l": "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68437", "l": "(3R,6R)-3-hydroxy-10'-apo-alpha-carotenal + O2 => (3R,6R)-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67665", "l": "[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O => 1,2-diacyl-sn-glycero-3-phosphoethanolamine-N-glycine + [protein]-C-terminal <stereo>L-</stereo>amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76692", "l": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione => (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209313", "l": "Autocleavage of HH (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0045499", "l": "chemorepellent activity", "d": ["Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-109534", "l": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1237325", "l": "Hemoglobin A is protonated and carbamated causing release of oxygen (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5655892", "l": "POLK incorporates dNMP opposite to damaged DNA base (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68087", "l": "GTP + L-histidyl-[RNA ligase] <=> diphosphate + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985138", "l": "OAS2 binds viral dsRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15359", "l": "demethyllactenocin + dTDP + H(+) => 5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19221", "l": "2 formaldehyde + H2O = formate + H(+) + methanol", "d": [], "t": []}, {"i": "EC:1.2.98.1", "l": "\"formaldehyde dismutase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18387", "l": "acetoacetate + 2 AMP + 4 H(+) + 4 phosphate => acetone + 2 ATP + 3 H2O + hydrogencarbonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-426223", "l": "Cation influx mediated by TRPC3/6/7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-266082", "l": "ABCG1-mediated transport of intracellular cholesterol to the cell surface (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797712", "l": "CDK12 stimulates expression of DNA repair genes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23246", "l": "H(+) + norspermidine + S-methyl-5'-thioadenosine => propane-1,3-diamine + S-adenosyl 3-(methylsulfanyl)propylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55821", "l": "a 7(1)-hydroxybacteriochlorophyllide d + H2O + S-adenosyl-L-methionine => 5'-deoxyadenosine + a 7(1),7(1)-dihydroxybacteriochlorophyllide d + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693807", "l": "FUCA1 hydrolyses NGP:1,6-GlcNAc (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-433104", "l": "NACT co-transports trivalent citrate and a sodium ion (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2250301", "l": "Formation of lysyl-pyrrole cross-links (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031827", "l": "type 2B serotonin receptor binding", "d": ["Binding to a type 2B serotonin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379382", "l": "MAOA:FAD deaminates DA to DOPAC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1474266", "l": "Formation of collagen fibrils (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0016618", "l": "hydroxypyruvate reductase [NAD(P)H] activity", "d": ["Catalysis of the reaction: (R)-glycerate + NAD(P)+ = 3-hydroxypyruvate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936947", "l": "Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-196125", "l": "Translocation of isocaproaldehyde from the mitochondrial matrix to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218815", "l": "p-6Y-VEGFR2 binds NCK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9024997", "l": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5692749", "l": "CDC14A,B bind MAPK6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5679206", "l": "MTMR14, MTMR3 dephosphorylate PI3P (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45589", "l": "a long-chain fatty acid + ATP + holo-[ACP] => a long-chain fatty acyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8869456", "l": "USP4 deubiquitinate TRAF2,TRAF6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-189242", "l": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54479", "l": "1-octadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + dodecanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70369", "l": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38822", "l": "1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39870", "l": "3-O-[Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CDP-L-ribitol <=> 3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0015280", "l": "ligand-gated sodium channel activity", "d": ["Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."], "t": []}, {"i": "REACT:R-HSA-2672334", "l": "SCNN channels transport extracellular Na+ to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835949", "l": "HIV Tat72 binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1296127", "l": "Activation of voltage gated Potassium channels (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16509", "l": "H(+) + oxalate = CO2 + formate", "d": [], "t": []}, {"i": "EC:4.1.1.2", "l": "\"oxalate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102330", "l": "palmitoyl-[acp] elongase/decarboxylase activity", "d": ["Catalysis of the reaction: malonyl-CoA + a palmitoyl-[acp] = 1-heptadecene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5362412", "l": "SYVN1 ubiquitinates Hh C-terminal fragments (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17081", "l": "(E)-isoeugenol + S-adenosyl-L-methionine = (E)-isomethyleugenol + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8980228", "l": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67138", "l": "3-hydroxypropanoyl-CoA + ADP + phosphate => 3-hydroxypropanoate + ATP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12826", "l": "[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine => [thioredoxin]-dithiol + H(+) + phosphate + sarcosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202331", "l": "Recruitment of PLC-gamma1 to SLP-76 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-428609", "l": "Type I Na+-coupled phosphate co-transport (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444126", "l": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24052", "l": "a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}, {"i": "EC:1.5.5.1", "l": "\"electron-transferring-flavoprotein dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38856", "l": "a 1,2-saturated fatty acid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a (R)-2-hydroxy fatty acid + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-373716", "l": "DCC interacting NCK-1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49937", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192051", "l": "CYP7A1 7-hydroxylates CHOL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50760", "l": "a quinone + H2O + sulfite = a quinol + sulfate", "d": [], "t": []}, {"i": "EC:1.8.5.6", "l": "\"sulfite dehydrogenase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8848658", "l": "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839402", "l": "TGFBR3 binding to GIPC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200720", "l": "SLC25A32 transports THF from mitochondrial matrix to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-917693", "l": "ESCRT Disassembly (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3451153", "l": "Beta-catenin recruits TRRAP/KAT5 HAT components (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-192335", "l": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56621", "l": "(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + H2O => 2,4,5-trichlorocyclohexa-2,5-dien-1-ol + chloride + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44737", "l": "acetyl-CoA + dihydroxyacetone phosphate => 3-hydroxy-2,4-dioxopentyl phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.1.47", "l": "\"dihydromethanopterin reductase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.120", "l": "\"oligoxyloglucan beta-glycosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9018808", "l": "RAC3 binds effectors at the plasma membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23228", "l": "L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.59", "l": "\"L-lysine N(6)-monooxygenase (NADPH)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5082409", "l": "Dissociation of HSF1:HSP90 complex in the nucleus (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32854", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 2-acylglycerol <=> a 1,2-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9668365", "l": "FVIIIa variant:FIXa does not convert FX to the active FXa (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-164845", "l": "Suicidal integration leading to inverted circle formation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162721", "l": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29467", "l": "H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1358790", "l": "RNF41 ubiquitinates ERBB3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9029434", "l": "p-S363,S380,T573 RS6K translocates to the nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8935732", "l": "RUNX1 binds SIN3A,(SIN3B) co-repressor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043721", "l": "4-hydroxybutanoyl-CoA dehydratase activity", "d": ["Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-349638", "l": "Disassembly of SR-BI-bound spherical HDL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-200555", "l": "Formation of Malonyl-CoA from Acetyl-CoA (liver) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43442", "l": "H2O + N-hexadecanoylsphinganine => hexadecanoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694428", "l": "LMAN family proteins bind glycosylated cargo (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9011543", "l": "DCA binds PDK2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77593", "l": "Cleavage and polyadenylation of Intronless Pre-mRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159783", "l": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8938815", "l": "RNF152 polyubiquitinates RRAGA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9754929", "l": "SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-749446", "l": "Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2187332", "l": "Cytosolic CMs translocate to extracellular region (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-70785", "l": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052667", "l": "phosphomethylethanolamine N-methyltransferase activity", "d": ["Catalysis of the reaction: N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6805640", "l": "AKT phosphorylates KAT6A (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39275", "l": "(2E,15Z)-tetracosadienoyl-CoA + H(+) + NADPH = (15Z)-tetracosenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44046", "l": "11,12-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604731", "l": "Autocatalytic activation of MMP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010294", "l": "abscisic acid glucosyltransferase activity", "d": ["Catalysis of the reaction: (+)-abscisate + UDP-D-glucose = abscisic acid glucose ester + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56255", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + O(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9842868", "l": "TRIM28 in TRIM28:KRAB-ZFP:retroelement chromatin autoSUMOylates with SUMO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69920", "l": "inosine(out) + 2 Na(+)(out) => inosine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015537", "l": "xanthosine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61523", "l": "AH2 + dopamine <=> 3-tyramine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0160079", "l": "G protein-coupled glycine receptor activity", "d": ["Combining with glycine and transmitting the signal across the membrane by changing the activity of intracellular G protein signaling."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40113", "l": "butanoate + CoA + H(+) => butanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54192", "l": "L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-174392", "l": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23675", "l": "a quinone + L-quinate <=> 3-dehydroquinate + a quinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45356", "l": "H2O + N-(11Z-eicosenoyl)-sphing-4-enine = (11Z)-eicosenoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25481", "l": "acetoacetate + succinyl-CoA => acetoacetyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75417", "l": "pseudooxynicotine => H2O + N-methylmyosmine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-211950", "l": "CYP24A1 24-hydroxylates CTL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-170159", "l": "Translocation of Cdc25 to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64457", "l": "L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine => 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55875", "l": "anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) <=> 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-351208", "l": "Spermidine  => N-acetylated spermidine (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663120", "l": "p-BMAL1:p-CLOCK,NPAS2 binds CRY1 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32107", "l": "3-methoxy-4',5-dihydroxy-trans-stilbene + S-adenosyl-L-methionine = H(+) + pterostilbene + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57543", "l": "a 5'-end NTP-ribonucleotide-RNA + H2O <=> a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-508162", "l": "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382613", "l": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43513", "l": "2-(dihydroxymethyl)-5-formylfuran + O2 => 2-carboxy-5-formylfuran + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71415", "l": "3,3',5-triiodo-L-thyronine(out) + L-phenylalanine(in) = 3,3',5-triiodo-L-thyronine(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4411373", "l": "NLK translocates to nucleus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23814", "l": "(1R,4S)-menthone + H(+) + NADPH => (+)-neomenthol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40625", "l": "2,3-ditetradecanoyl-sn-glycerol + H(+) + tetradecanoate => H2O + tritetradecanoylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29220", "l": "a menaquinone + sn-glycerol 3-phosphate => a menaquinol + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-912408", "l": "Telomeres cluster at the nuclear membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-194632", "l": "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-994106", "l": "HP1 alpha binds Histone H3K9(me)3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047674", "l": "apiose 1-reductase activity", "d": ["Catalysis of the reaction: D-apiitol + NAD+ = D-apiose + H+ + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42828", "l": "2-hydroxy-5-methyl-1-naphthoate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 2,7-dihydroxy-5-methyl-1-naphthoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.31", "l": "\"2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16926", "l": "(E)-caffeoyl-CoA + S-adenosyl-L-methionine => (E)-feruloyl-CoA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672017", "l": "Rheb in the MTORC1 complex hydrolyses GTP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5626549", "l": "IQGAPs bind CALM1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932276", "l": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58116", "l": "L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.376", "l": "\"EGF-domain serine glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5690517", "l": "PPT1 hydrolyses palmitoylated proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16392", "l": "4-hydroxybenzoate + 2 H(+) + NADH + O2 <=> CO2 + H2O + hydroquinone + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066779", "l": "Conversion of DHA-CoA to docosahexaenoic acid (DHA) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-198609", "l": "AKT phosphorylates TSC2, inhibiting it (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57729", "l": "H(+) + trans-aconitate => CO2 + itaconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0010945", "l": "coenzyme A diphosphatase activity", "d": ["Catalysis of the reaction:an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + 4'-phosphopantetheine. This reaction can also use coenzyme A as a substrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22999", "l": "H2O2 + L-ascorbate <=> 2 H2O + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48518", "l": "dodecanoate + dodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H(+) => 1,2-didodecanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2473186", "l": "FSTL3 binds Activin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-428909", "l": "Activated TP receptor binds G-protein  G13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54598", "l": "2-hydroxyhexadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + hexadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32968", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + H2O => a fatty acid + H(+) + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47143", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.2.-.-", "l": "\"Acting on the aldehyde or oxo group of donors\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28557", "l": "D-mannose 6-phosphate + H2O <=> D-mannose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0004615", "l": "phosphomannomutase activity", "d": ["Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57679", "l": "4-epi-eremophilene + O2 + reduced [NADPH--hemoprotein reductase] <=> 4-epi-eremophilene-2beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209921", "l": "Monoiodinated tyrosine can be deiodinated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46006", "l": "2-methylpropanoyl-CoA + H(+) + NADH => 2-methylpropanal + CoA + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034794", "l": "cyclopropanecarboxyl-CoA decyclase activity", "d": ["Catalysis of the reaction: cyclopropanecarboxyl-CoA = crotonoyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169895", "l": "Crk's SH3 domain engages C3G (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-937034", "l": "IRAK1 phosphorylates Pellino (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56449", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O => (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59832", "l": "ATP + N(6)-(D-fructosyl)-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-fructosyl)-L-lysyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.1.171", "l": "\"protein-fructosamine 3-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-191101", "l": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66209", "l": "(8R)-8-hydroxynonanoyl-CoA + O2 => (2E,8R)-8-hydroxynonenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19900", "l": "H(+) + 2 L-arginine + 3 NADPH + 4 O2 <=> 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.99.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5662613", "l": "MT3 exchanges zinc for copper (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5218809", "l": "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.3.-", "l": "\"Sialyltransferases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046087", "l": "Translocation of tetracosahexaenoyl-CoA to peroxisomes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8855825", "l": "HTRA1 hydrolyzes ACAN (Aggrecan) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71164", "l": "HGD dioxygenates homogentisate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0140319", "l": "receptor decoy activity", "d": ["Binding and sequestering a specific receptor ligand to prevent it from binding to its regular receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62492", "l": "ATP + holo-[peptidyl-carrier protein] + L-arginine = AMP + diphosphate + L-arginyl-[peptidyl-carrier protein]", "d": [], "t": []}, {"i": "EC:6.2.1.63", "l": "\"L-arginine--[L-arginyl-carrier protein] ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029457", "l": "Cross-linking of FCGRIIIA with IgG-coated Ag (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1592244", "l": "AMPK phosphorylates PPARGC1A (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22801", "l": "cycloeucalenol => obtusifoliol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71294", "l": "(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) <=> (R)-carnitine(in) + chloride(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50024", "l": "dodecanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46429", "l": "4beta-hydroxycholesterol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => (25R)-4beta,26-dihydroxycholesterol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-73788", "l": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9833777", "l": "PKR binds activating host RNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8858252", "l": "HDLBP binds HDL (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9661419", "l": "ALB binds extracellular heme (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2130500", "l": "Insertion of MHC II:Ii complex in to the plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11994", "l": "H(+) + H2O2 + L-1-piperideine-6-carboxylate => L-pipecolate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15578", "l": "H2O + uridine => D-ribose + uracil", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047543", "l": "2-hexadecenal reductase activity", "d": ["Catalysis of the reaction: NADP+ + palmitaldehyde = trans-hexadec-2-enal + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71737", "l": "formate + succinyl-CoA => formyl-CoA + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74816", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA => 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8878654", "l": "ACP6 hydrolyses MYS-LPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683801", "l": "CHEK2 phosphorylates BRCA1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-198314", "l": "DAG stimulates protein kinase C-delta (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71446", "l": "3-O-methyl-L-dopa(out) + L-phenylalanine(in) <=> 3-O-methyl-L-dopa(in) + L-phenylalanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9025957", "l": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58018", "l": "6alpha,8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5654571", "l": "Activated FGFR1 binds FRS3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-984671", "l": "Chromokinesins form dimers (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5205672", "l": "Uncleaved Pink1 accumulates in damaged mitochondria (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2507854", "l": "MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33786", "l": "1(F)-beta-D-fructosylsucrose + sucrose <=> 1,6-kestotetraose + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1369065", "l": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-444393", "l": "RhCG mediates ammonium influx into kidney collecting duct cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4570496", "l": "SUMOylation of Histone H4 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-186826", "l": "GRB2:SOS1 complex binds to the active receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31550", "l": "2 (2E,6E)-farnesyl diphosphate <=> 15-cis-4,4'-diapophytoene + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9623384", "l": "α1-agonists bind ADRA1A,B,D (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-975097", "l": "Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1675883", "l": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-450063", "l": "Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9603983", "l": "FUT2 transfers Fuc to LeX to form LeY (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371422", "l": "ATP hydrolysis by HSP70 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9668389", "l": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74819", "l": "glutathione(in) = glutathione(out)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-204600", "l": "Basigin homodimerises (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11387", "l": "(S)-2-hydroxyoctadecanoate + NAD(+) <=> 2-oxooctadecanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47313", "l": "estrone + O2 + reduced [NADPH--hemoprotein reductase] => 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-140736", "l": "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1855218", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76091", "l": "(11R)-19-hydroxycarlactone + O2 + reduced [NADPH--hemoprotein reductase] = (11R)-19-oxocarlactone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4615889", "l": "SUMOylation of HDAC1 with SUMO1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.1.105", "l": "\"L-tryptophan decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8875558", "l": "RAPGEF1 binds CRK,CRKL (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3315483", "l": "Phosphorylated SMAD2/3 MH2 Domain Mutants do not bind SMAD4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1013012", "l": "Binding of Gbeta/gamma to GIRK/Kir3 channels (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71923", "l": "2 Na(+)(out) + taurochenodeoxycholate(out) = 2 Na(+)(in) + taurochenodeoxycholate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43346", "l": "[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + diphosphate => [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14949", "l": "A + H2O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2", "d": [], "t": []}, {"i": "EC:1.3.99.19", "l": "\"quinoline-4-carboxylate 2-oxidoreductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5690856", "l": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67639", "l": "(2S)-2-amino-2'-deoxyadenylo-succinate <=> dZMP + fumarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1604752", "l": "Initial activation of proMMP13 by MMP3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9029580", "l": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374173", "l": "AGT(34-41) binds to AGTR1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48432", "l": "ATP + N(6)-D-ribulosyl-L-lysyl-[protein] = ADP + H(+) + N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56971", "l": "dCTP + pyruvate <=> dCDP + H(+) + phosphoenolpyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5623525", "l": "Cargo-carrying vesicles bud from the TGN (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964340", "l": "Gq-BTK complex dissociates to Active BTK and Gq (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72399", "l": "2-oxoglutarate(out) + estrone 3-sulfate(in) = 2-oxoglutarate(in) + estrone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9756180", "l": "CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43673", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol => 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78330", "l": "D-erythrose 4-phosphate + L-erythrulose <=> beta-D-fructose 6-phosphate + glycolaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74859", "l": "dopamine + formaldehyde = H2O + norsalsolinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32658", "l": "a carboxylate + eugenol + NADP(+) <=> a coniferyl ester + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-420977", "l": "Ca permeable AMPA receptor ligand binding (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51616", "l": "ATP + formate + H(+) = CO2 + dATP + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627369", "l": "SEPT4 binds XIAP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-159761", "l": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3228469", "l": "MAP3K5 phosphorylates MKK3 and MKK6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45207", "l": "Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol <=> H2O + methyl-Co(III)-[methanol-specific corrinoid protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41125", "l": "(9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74519", "l": "1-(3-O-sulfo-beta-D-galactosyl)-ceramide + H2O = beta-D-Gal-(1<->1')-Cer + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:5.3.2.n1", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66880", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate = 10-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6810376", "l": "ING2 binds PI5P (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15700", "l": "(2S)-liquiritigenin + O2 + reduced [NADPH--hemoprotein reductase] <=> 2 H(+) + H2O + licodione + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8875902", "l": "SLC45A3 transports Glc from extracellular region to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5694409", "l": "Nucleotide exchange on RAB1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40125", "l": "an omega-oxo fatty acid + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => an omega-hydroxy fatty acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14888", "l": "H2O + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] <=> ADP-D-ribose + L-arginyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56305", "l": "ATP + H2O + rifampicin => 21-phosphorifampicin + AMP + 2 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5653850", "l": "Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8868071", "l": "Clathrin recruits PIK3C2A (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9657606", "l": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31162", "l": "(3S)-hydroxyhexadecanoyl-CoA + NAD(+) <=> 3-oxohexadecanoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204813", "l": "Interaction of Tie2 and Grb14 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-189439", "l": "ALAD condenses 2 dALAs to form PBG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9836606", "l": "SPHK1 binds PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67242", "l": "adenosine + H(+) + L-methionine => (R)-S-adenosyl-L-methionine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8852167", "l": "ADRB2:Catecholamine binds ARRB1, ARRB2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102454", "l": "cyanidin 3-O-galactosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin + UDP-D-galactose = cyanidin 3-O-beta-D-galactoside betaine + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1295609", "l": "SRC phosphorylates SPRY2 on Y55 and Y227 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654641", "l": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39468", "l": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH => (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9648949", "l": "HTR3A antagonists bind HTR3A pentamer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55179", "l": "2-oxoglutarate + butanoyl-CoA + O2 <=> 2-hydroxybutanoyl-CoA + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72203", "l": "2 chloride(out) + hydrogencarbonate(in) = 2 chloride(in) + hydrogencarbonate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5683967", "l": "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944242", "l": "Association of procollagen type XXVII (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6806957", "l": "MET receptor dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-975635", "l": "BCMO1:Fe2+ cleaves betaC to atRAL (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1861789", "l": "GBA3 hydrolyzes GlcCer (cytosol) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8933547", "l": "MCAT transfers Mal from Mal-CoA to NDUFAB1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21916", "l": "an aliphatic amine + 2 Fe(III)-[cytochrome c550] + H2O = an aldehyde + 2 Fe(II)-[cytochrome c550] + 2 H(+) + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5676598", "l": "TRAF2:cIAP1/2 complex binds FN14:TWEAK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9762282", "l": "CTNNB1 dissociates from CDH11 upon ANGPTL4 binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043287", "l": "poly(3-hydroxyalkanoate) binding", "d": ["Binding to a poly(3-hydroxyalkanoate), a polyester of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58333", "l": "(E)-non-2-en-1-ol + NADP(+) => (E)-non-2-enal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5667008", "l": "RHOA:GTP binds RHPN1 or RHPN2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30543", "l": "(S)-carnitine + ATP + CoA = (S)-carnitinyl-CoA + ADP + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9649732", "l": "Mature S-Farn-Me KRAS4B translocates to plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24292", "l": "acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate", "d": [], "t": []}, {"i": "EC:2.3.1.1", "l": "\"amino-acid N-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9749977", "l": "UGT1A6 glucuronates ST (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-77085", "l": "Dissociation of  transcript with 5'-GMP from GT (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8949649", "l": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-399952", "l": "Phosphorylation of LIMK-1 by PAK (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990644", "l": "microtubule site clamp", "d": ["The binding activity of a molecule that attaches the spindle microtubules to the kinetochore."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.77", "l": "\"mannan 1,2-(1,3)-alpha-mannosidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6797606", "l": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15385", "l": "L-asparagine = 3-cyano-L-alanine + H2O", "d": [], "t": []}, {"i": "EC:4.2.1.65", "l": "\"3-cyanoalanine hydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1855223", "l": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43122", "l": "CO2 + succinate + urate => 2-oxoglutarate + O2 + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34510", "l": "2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + H2O + phosphoenolpyruvate <=> N,N-diacetyllegionaminate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6783524", "l": "OSM,LIF,CTF1 receptor complex binds gp130 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033461", "l": "GGU codon-amino acid adaptor activity", "d": ["A triplet codon-amino acid adaptor activity that recognizes a GGU codon."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5696958", "l": "USP44 deubiquitinates CDC20 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68943", "l": "Na(+)(in) + tellurite(in) <=> Na(+)(out) + tellurite(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9708866", "l": "pro-F2R binds vorapaxar (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8944261", "l": "Association of procollagen type XIII (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70573", "l": "argininosuccinate <=> fumarate + arginine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3204303", "l": "MRE11 binds cytosolic DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-195300", "l": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52296", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76504", "l": "4-O-beta-D-glucosyl-trans-ferulate + H2O => 4-O-beta-D-glucosyl-vanillin + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53991", "l": "H2O + O-phospho-L-threonyl-[myosin light chain] <=> L-threonyl-[myosin light chain] + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57889", "l": "a quinone + 5 H(+)(in) + NADH => a quinol + 4 H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9630769", "l": "OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68528", "l": "(2E,6E)-farnesyl diphosphate = beta-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5694415", "l": "SEC24A,B:SEC23A bind SEC22B (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54834", "l": "a 12-hydroxyjasmonyl-L-alpha-amino acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => a jasmonyl-L-amino acid + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8866277", "l": "AP-2 directly binds some endocytic cargo (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "81.71648590403835", "identifiers": [{"i": "GO:0036361", "l": "racemase activity, acting on amino acids and derivatives", "d": ["Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.8.3.15", "l": "\"succinyl-CoA:(R)-benzylsuccinate CoA-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30031", "l": "(S)-muconolactone = cis,cis-muconate + H(+)", "d": [], "t": []}, {"i": "EC:5.5.1.1", "l": "\"muconate cycloisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59066", "l": "luteothin + S-adenosyl-L-homocysteine => demethylluteothin + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2314686", "l": "ASA- acetylates PTGS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696004", "l": "ACSF2 ligates CoA-SH to MCFA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17175", "l": "glutathione + spermidine => glutathionylspermidine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70901", "l": "(2R)-3-phosphoglycerate + alpha-D-ribose 1,5-bisphosphate + H(+) => (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.44", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5223304", "l": "DAG and Ca+2 bind to PKC and tether it to membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-70349", "l": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008431", "l": "vitamin E binding", "d": ["Binding to a vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-69016", "l": "Ubiquitinated Cdc6 is degraded by the proteasome (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-382056", "l": "Crk binds to the active PDGF receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8984021", "l": "STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047337", "l": "dolichyl-diphosphate-polyphosphate phosphotransferase activity", "d": ["Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015123", "l": "acetate transmembrane transporter activity", "d": ["Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-176054", "l": "GST dimers conjugate GSH with cytosolic substrates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51289", "l": "(11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate => (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-68946", "l": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73963", "l": "(2E,6E)-farnesyl diphosphate = aristolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-162742", "l": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25838", "l": "5-deoxy-D-glucuronate + H(+) => 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78117", "l": "a 1,2-diacylglycerol + an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base => a 1,2-diacyl-3-(9Z,12Z-octadecadienoyl)-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3781024", "l": "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69848", "l": "a 5,6-dihydrouridine in RNA + NADP(+) => a uridine in RNA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350769", "l": "trans-Golgi Network Coat Activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40551", "l": "demethylphylloquinol + S-adenosyl-L-methionine = H(+) + phylloquinol + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.329", "l": "\"demethylphylloquinol methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69513", "l": "H2O + N-acetyl-D-galactosamine + O2 => H(+) + H2O2 + N-acetyl-D-galactosaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33090", "l": "cyclic dehypoxanthinylfutalosinate <=> 1,4-dihydroxy-6-naphthoate + dihydroxyacetone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75539", "l": "(2E)-decenoate + ATP + holo-[ACP] = (2E)-decenoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25729", "l": "H(+) + H2O + N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase] => N-hydroxy-L-tetrahomomethionine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0045158", "l": "electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity", "d": ["Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9665388", "l": "ERBB2 ECD mutants heterodimerize with EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675198", "l": "Activated MAPKs phosphorylate BRAF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-168849", "l": "tBID binds to inactive BAX protein (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-109998", "l": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64322", "l": "cholesteryl (9Z)-hexadecenoate + CoA => (9Z)-hexadecenoyl-CoA + cholesterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11476", "l": "glycerol 1-phosphate + H2O = glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193800", "l": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27746", "l": "H(+) + L-cysteine = CO2 + cysteamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5687664", "l": "FEN1 cleaves displaced ssDNA flaps during MMEJ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5578712", "l": "Importin-8 binds AGO2:miRNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46757", "l": "a 1-acyl-2-hexadecanoyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5610749", "l": "cAMP dissociates PKA, promoting GLI processing (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14026", "l": "H(+) + H2O + sepiapterin => NH4(+) + xanthopterin-B2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-744230", "l": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17141", "l": "glycine + oxaloacetate = glyoxylate + L-aspartate", "d": [], "t": []}, {"i": "EC:2.6.1.35", "l": "\"glycine--oxaloacetate transaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30214", "l": "2 Fe(III)-[cytochrome c] + H2O + nitrous oxide <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + 2 nitric oxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6801462", "l": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8956106", "l": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799409", "l": "HIPK2 phosphorylates TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-417820", "l": "P2Y9 receptor can bind to LPA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1562641", "l": "Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76025", "l": "18-oxocortisol + 2 H2O + 2 oxidized [adrenodoxin] => 18-hydroxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2161745", "l": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0009784", "l": "transmembrane receptor histidine kinase activity", "d": ["Combining with a signal and transmitting the signal from one side of a membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-420274", "l": "GIP receptor binds gastric inhibitory peptide (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60736", "l": "(2E,6E)-farnesal + H2O + NADP(+) = (2E,6E)-farnesoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983300", "l": "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10753", "l": "[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n) + n ATP + n D-aspartate => [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + n ADP + n H(+) + n phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047966", "l": "glycosulfatase activity", "d": ["Catalysis of the reaction: D-glucose 6-sulfate + H2O = D-glucose + H+ + sulfate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6792712", "l": "KAT5 acetylates ATM at shortened telomeres (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18464", "l": "1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-917870", "l": "SLC46A1 transports hemes from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36814", "l": "acetyl-CoA + GDP-alpha-D-perosamine <=> CoA + GDP-N-acetyl-alpha-D-perosamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-112383", "l": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-186780", "l": "PI3-kinase binds to the active receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199935", "l": "MSK1 activates CREB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77822", "l": "H2O + N-(1-deoxy-beta-D-fructopyranos-1-yl)-L-alanine + O2 <=> 2-dehydro-D-glucose + H2O2 + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69529", "l": "chorismate + H2O + 2 L-glutamine => 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70350", "l": "bromide + L-tyrosine + NADP(+) <=> 3-bromo-L-tyrosine + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56236", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17599", "l": "D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+) => D-mannitol + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16886", "l": "2 (4E,15E)-bilirubin IXalpha C8-beta-D-glucuronoside => (4Z,15Z)-bilirubin IXalpha + bilirubin IXalpha bis-beta-D-glucuronoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140839", "l": "RNA polymerase II CTD heptapeptide repeat P3 isomerase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) (position 3) = RNA polymerase II large subunit trans-proline (omega=0) (position 3)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-376887", "l": "2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030560", "l": "tRNA pseudouridylation guide activity", "d": ["Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53500", "l": "1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-158925", "l": "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1250462", "l": "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61362", "l": "ADP + H(+) + pheophorbide a(out) + phosphate => ATP + H2O + pheophorbide a(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44287", "l": "2 H(+) + 2 malonyl-CoA + octanoyl-CoA <=> 4-hydroxy-6-heptylpyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9006422", "l": "IFNG gene expression is stimulated by RUNX1 and inhibited by FOXP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1675836", "l": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51780", "l": "4-prenylphlormethylbutanophenone + dimethylallyl diphosphate = deoxyadlupulone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13345", "l": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]", "d": [], "t": []}, {"i": "EC:2.5.1.58", "l": "\"protein farnesyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56191", "l": "3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051379", "l": "epinephrine binding", "d": ["Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66294", "l": "an alpha-D-mannosylinositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP + H(+) => an inositol-1-phospho-N-(2-hydroxyacyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176250", "l": "Binding of ATR-ATRIP to the RPA-ssDNA complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9686521", "l": "CDK2:CCNA phosphorylates TERF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5221130", "l": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12514", "l": "H2O2 + NH4(+) + oxaloacetate => D-aspartate + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1855169", "l": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-173512", "l": "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-174119", "l": "Free APC/C phosphorylated by Plk1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603991", "l": "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73886", "l": "guanidine(out) <=> guanidine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10245", "l": "4-fumarylacetoacetate + H2O => acetoacetate + fumarate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-191422", "l": "Mevalonate-5-phosphate is further phosphorylated. (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158419", "l": "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0019178", "l": "NADP phosphatase activity", "d": ["Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67950", "l": "3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675948", "l": "TNFRSF6B binds TNFSF6,14,15 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47838", "l": "[5-(aminomethyl)furan-3-yl]methyl diphosphate + ADP => [5-(aminomethyl)-3-furyl]methyl phosphate + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54348", "l": "1-O-hexadecyl-2-acetyl-sn-glycerol + CDP-choline = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791057", "l": "Expression of TSPYL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-204863", "l": "Interaction of Tie2 with Ang2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12433", "l": "L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine => H(+) + tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2396029", "l": "Latent TGF-beta-3 binds integrins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53376", "l": "5,6-dihydrouridine(16) in tRNA + NADP(+) = H(+) + NADPH + uridine(16) in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047989", "l": "hydroxybutyrate-dimer hydrolase activity", "d": ["Catalysis of the reaction: (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate + H2O = 2 (R)-3-hydroxybutanoate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.13", "l": "\"phospho-N-acetylmuramoyl-pentapeptide-transferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190261", "l": "FGFR3c binds to FGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71641", "l": "K(+)(out) + Na(+)(out) => K(+)(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55134", "l": "AMP + D-alanyl-[D-alanyl-carrier protein] + diphosphate => ATP + D-alanine + holo-[D-alanyl-carrier protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-157937", "l": "NICD3 traffics to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9833107", "l": "Association of NS1 (1C) with Cul5 and SCF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-139919", "l": "Translocation of BIM to mitochondria (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687101", "l": "p-T182 MAPKAPK5 phosphorylates FOXO3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.2.28", "l": "\"alpha-L-rhamnosyl-(1->4)-beta-D-glucuronate lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382575", "l": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72915", "l": "D-fructopyranose(out) + Na(+)(out) = D-fructopyranose(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33016", "l": "[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 => [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-139919", "l": "Translocation of BIM to mitochondria (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193781", "l": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34195", "l": "2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + 2 H(+) + O2 = 2 aureusidin 6-O-beta-glucoside + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72430", "l": "chloride(in) + K(+)(in) <=> chloride(out) + K(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9733960", "l": "Bile salts and acids dissociate from ALB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353318", "l": "Insertion of correct bases opposite to the lesion by Pol kappa (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30101", "l": "2-demethylmenaquinol-8 + CO2 + diphosphate => 1,4-dihydroxy-2-naphthoate + all-trans-octaprenyl diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5654407", "l": "Activated FGFR2 phosphorylates SHC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-375160", "l": "NCAM1 binds to ATP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35845", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a cardiolipin => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67990", "l": "N-acetyl-D-glutamine => N-acetyl-L-glutamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358792", "l": "RNF41 ubiquitinates activated ERBB3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68785", "l": "(2Z,6Z)-farnesyl diphosphate => diphosphate + gamma-curcumene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24500", "l": "adenosine 5'-tetraphosphate + H2O = ATP + H(+) + phosphate", "d": [], "t": []}, {"i": "EC:3.6.1.14", "l": "\"adenosine-tetraphosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23746", "l": "3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate => 2-oxoglutarate + L-histidinol phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68697", "l": "17beta-estradiol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 17beta-estradiol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-159729", "l": "Gamma-carboxy pro-protein S transport from the endoplasmic reticulum to the Golgi apparatus (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1604741", "l": "Initial activation of proMMP13 by MMP14 (MT1-MMP) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66873", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] => 9-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8985943", "l": "p-Y701-STAT1 dimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55098", "l": "(3S)-3-hydroxypentanoate + CoA + H(+) => (3S)-3-hydroxypentanoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-70979", "l": "MDH2 dimer dehydrogenates MAL (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5138432", "l": "DVL2 is phosphorylated by PKC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70560", "l": "3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H2O => L-threonyl-[protein] + N-acetyl-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8854041", "l": "SCF-FBXL7 ubiquitinates AURKA (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24989", "l": "(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol + H(+) + O2 + 2 reduced [adrenodoxin] => calcitroate + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5250947", "l": "B-WICH complex binds rDNA promoter (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166041", "l": "Transfer of LPS onto TLR4 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-873951", "l": "SGT1:HSP90 binds inactive NLRP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59639", "l": "D-xylotriose + O2 <=> D-xylotriono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13443", "l": "H(+) + NH4(+) + pyruvate + sulfite => H2O + L-cysteate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9726509", "l": "NR3C2 binds fludrocortisone (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250380", "l": "Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1655831", "l": "SREBP1A,1C,2 translocates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55902", "l": "6-chloro-L-tryptophan + FAD + 2 H2O => chloride + FADH2 + L-tryptophan + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6785821", "l": "SOCS5,(SOCS1) bind IL4RA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856808", "l": "Recruitment of AP-2 complex and clathrin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5649873", "l": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-379393", "l": "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9718360", "l": "GNRHR binds GNRHR peptide agonists (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77537", "l": "H(+) + L-methionine + tRNA(Leu) => H2O + L-methionyl-tRNA(Leu)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60182", "l": "ADP + D-fructose(in) + H(+) + phosphate => ATP + D-fructose(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446215", "l": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9010681", "l": "PKC phosphorylates ROBO3.1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47415", "l": "a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-mannopyranosyl-(1<->6)-D-myo-inositol] + an acyl-CoA <=> a 1,2-diacyl-sn-glycero-3-phospho-[alpha-D-6-acyl-mannopyranosyl-(1<->6)-D-myo-inositol] + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1296039", "l": "Activation of Ca2+ activated Potassium channels with small conductance (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-4167511", "l": "HLCS biotinylates ACACB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39871", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 3-acyl-sn-glycerol = a 1,3-diacyl-sn-glycerol + a 1-acyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30423", "l": "(2E,6E)-farnesyl diphosphate = (+)-delta-selinene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.76", "l": "\"(+)-delta-selinene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8866283", "l": "ARBB recruits GPCRs into clathrin-coated pits (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68507", "l": "(2Z,6Z)-farnesyl diphosphate <=> (Z)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2029270", "l": "Recruitment of PLCgamma to membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112604", "l": "Phosphorylated STATs are released (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66581", "l": "3'-phosphoadenylyl sulfate + bisphenol A => adenosine 3',5'-bisphosphate + bisphenyl A sulfate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41090", "l": "1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol <=> 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6807118", "l": "USP7 deubiquitinates monoubiquitinated PTEN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23263", "l": "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) <=> 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50177", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 => N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0141046", "l": "Atg8-family conjugating enzyme activity", "d": ["Isoenergetic transfer of an Atg8 family modifier from one protein to a phosphatidylethanolamine or phosphatidylserine on a membrane, via the reaction X-Atg8 + Y = Y-Atg8 + X."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3321883", "l": "MSL acetylates histone H4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654416", "l": "Activated FGFR3:pFRS binds GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-443986", "l": "Receptor ACKR2 binds most inflammatory CC chemokines (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78623", "l": "ATP + L-lysyl-5'-AMP = L-lysine + P(1),P(4)-bis(5'-adenosyl) tetraphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61143", "l": "(2R,3R)-dihydromyricetin + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + myricetin + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4167509", "l": "Mitochondrial BTD hydrolyses BCTN (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56279", "l": "ATP + L-proline <=> 3'-L-prolyl-AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964242", "l": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-3371582", "l": "HSBP1 binds HSF1 trimer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44871", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + ethanol <=> 1,2-diacyl-sn-glycero-3-phosphoethanol + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12788", "l": "an alditol + NAD(+) <=> an aldose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75191", "l": "2-dehydro-3-deoxy-L-fuconate + NAD(+) = 2,4-didehydro-3-deoxy-L-rhamnonate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9757462", "l": "Hydroxyl radicals oxidize ST to 2,3-DHBA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.42", "l": "\"complement subcomponent C1s\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876190", "l": "RAB8 GEFs exchange GTP for GDP on RAB8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75729", "l": "(10S)-hydroxy-(12Z)-octadecenoate => (10E,12Z)-octadecadienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47433", "l": "(7Z)-hexadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] => (2E,7Z)-hexadecadienoyl-CoA + reduced [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5627275", "l": "GOPC promotes translocation of CFTR to lysosomes (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.1.61", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-548831", "l": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36724", "l": "2-phenylethylamine + A + H2O => 2-phenylacetaldehyde + AH2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-727807", "l": "SLC35A1 exchanges CMP-Neu5Ac for CMP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8875320", "l": "RAB5 GEFs exchange GTP for GDP on RAB5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71638", "l": "phosphate(in) + 2 thiosulfate(out) <=> phosphate(out) + 2 thiosulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1433415", "l": "Activation of RAC1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-373716", "l": "DCC interacting NCK-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031693", "l": "alpha-1D adrenergic receptor binding", "d": ["Binding to an alpha-1D adrenergic receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45068", "l": "(R)-carnitine + an acyl-CoA = CoA + O-acyl-(R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5423117", "l": "PHF8 demethylates MeK21-histone H4 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110164", "l": "SMUG1 glycosylase mediated recognition and binding of uracil in DNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5688884", "l": "Defective CSF2RB does not bind SFTPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61132", "l": "(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 = CO2 + H(+) + H2O + kaempferol + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20605", "l": "cytosine + H(+) + H2O = NH4(+) + uracil", "d": [], "t": []}, {"i": "EC:3.5.4.1", "l": "\"cytosine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8866329", "l": "MTTP lipidates APOB-100, forming a pre-VLDL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204549", "l": "Caveolin-1 binds Basigin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51775", "l": "dimethylallyl diphosphate + phlorisobutanophenone <=> 4-prenylphlorisobutanophenone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66902", "l": "CO2 + 2 CoA + cyclo-acetoacetyl-L-tryptophan + H2O => acetyl-CoA + L-tryptophan + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373086", "l": "Receptor CCR10 binds CCL27 and 28 ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004729", "l": "oxygen-dependent protoporphyrinogen oxidase activity", "d": ["Catalysis of the reaction: 3 O2 + protoporphyrinogen IX = 3 H2O2 + protoporphyrin IX."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5690996", "l": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3371582", "l": "HSBP1 binds HSF1 trimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9839379", "l": "TGFBR3 binding to FGF2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654633", "l": "Activated FGFR3:p-FRS bind to PPTN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-880033", "l": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70068", "l": "a C29-steroid + O2 + reduced [NADPH--hemoprotein reductase] => a (22S)-22-hydroxy C29-steroid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28644", "l": "(2E,6E)-farnesyl diphosphate => alpha-zingiberene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14369", "l": "2-phosphoglycolate + H2O = glycolate + phosphate", "d": [], "t": []}, {"i": "EC:3.1.3.18", "l": "\"phosphoglycolate phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63093", "l": "H(+) + ilicicolin A + NADPH + O2 => H2O + ilicicolin A epoxide + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8943987", "l": "SCUBE1, SCUBE3 oligomerize (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-4568863", "l": "SUMOylation of RAD52 with SUMO1 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73104", "l": "diosmetin + S-adenosyl-L-methionine => luteolin 4',7-dimethyl ether + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18183", "l": "(S)-malate + CoA + H(+) => acetyl-CoA + glyoxylate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102404", "l": "linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity", "d": ["Catalysis of the reaction: linalyl 6-O-alpha-L-arabinopyranosyl- beta-D-glucopyranoside + H2O = vicianose + linalool."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661256", "l": "AKR1A1 reduces D-glucuronate to L-gulonate (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110145", "l": "AMP + ATP <=> ADP + ADP [AK2] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59723", "l": "D-maltohexaono-1,5-lactone + H2O <=> D-maltohexaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-434989", "l": "SEMA7A binds to PLXNC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2029989", "l": "Autocatalytic phosphorylation of overexpressed FGFR2 variants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23151", "l": "ATP + propanoate <=> ADP + propanoyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32324", "l": "ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] => ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801776", "l": "REG3A binds bacterial phospholipids (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013147", "l": "RAC1 GDIs block activation of RAC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19358", "l": "H(+) + L-proline betaine + NADPH + O2 => formaldehyde + H2O + N-methyl-L-proline + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1918092", "l": "CHIP (STUB1) mediates ubiquitination of ERBB2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9700175", "l": "Active ALK phosphorylates SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2168038", "l": "Collagen type XV restin release (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9675215", "l": "Formation of the RBBP5:ASH2L heterodimer (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19885", "l": "(S)-reticuline + O2 = (S)-scoulerine + H(+) + H2O2", "d": [], "t": []}, {"i": "EC:1.21.3.3", "l": "\"reticuline oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9756169", "l": "CYP3A4 monooxygenates ATV to 2-OH-ATV (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71242", "l": "2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH <=> 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8873929", "l": "Casein kinase II phosphorylates STARD10 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9661417", "l": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-170825", "l": "glucokinase [nucleoplasm] => glucokinase [cytosol] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68646", "l": "alpha-thujene + diphosphate => (2E)-geranyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77378", "l": "H(+) + heptadecanoate + hnu <=> CO2 + hexadecane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-202626", "l": "I-Smad competes with Co-Smad for R-Smad1/5/8 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2162192", "l": "COQ2 ligates all-E-10PrP2 to PHB (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50151", "l": "a fatty acid ethyl ester + H2O <=> a fatty acid + ethanol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-429594", "l": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67093", "l": "ATP + docosanoate(in) + H2O => ADP + docosanoate(out) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30706", "l": "H(+) + salicylate <=> CO2 + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2509838", "l": "ITPA hydrolyses dITP to dIMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005364", "l": "maltose:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6805122", "l": "AURKB binds TP53 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-163825", "l": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2328033", "l": "Fibrillin-1 binds latent TGF-beta (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15229", "l": "alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-alpha-D-mannose", "d": [], "t": []}, {"i": "EC:2.7.7.13", "l": "\"mannose-1-phosphate guanylyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9710263", "l": "GZMB cleaves GSDME (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "88.184450420133103", "identifiers": [{"i": "GO:0035325", "l": "Toll-like receptor binding", "d": ["Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71537", "l": "D-glucose 6-phosphate(out) + phosphate(in) => D-glucose 6-phosphate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564164", "l": "Collagen type V degradation by MMP2,9,10 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3296309", "l": "HCAR3 binds HCAR3 ligands (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874205", "l": "MBTPS1 (S1P) cleaves CREB3L2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77608", "l": "Binding of A1CF to stem-looped RNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15566", "l": "an N-acyl-L-amino acid + H2O => a carboxylate + an L-alpha-amino acid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2730896", "l": "Phosphorylation of MEK4 by MEKK1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29159", "l": "3 a menaquinol(in) + 2 H(+)(out) + nitrite(out) = 3 a menaquinone(in) + 2 H2O(out) + NH4(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204647", "l": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015090", "l": "low-affinity ferric iron ion transmembrane transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45761", "l": "dTDP-beta-L-daunosamine + epsilon-rhodomycinone => dTDP + H(+) + rhodomycin D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-449087", "l": "CD4 binds Interleukin-16 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9705137", "l": "TBK1 or IKBKE forms homodimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-449117", "l": "TXLNA (IL14) binds syntaxin1A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64927", "l": "dATP + 2 H2O <=> dAMP + 2 H(+) + 2 phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015483", "l": "long-chain fatty acid transporting porin activity", "d": ["Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria."], "t": []}, {"i": "TCDB:1.B.9.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62907", "l": "an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + GDP-beta-L-fucose <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.71", "l": "\"alcohol dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8987150", "l": "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046098", "l": "Activation of linoleic acid to linoleoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2203479", "l": "STAB2 (FEEL-2) binds ligands (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21458", "l": "(S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020278", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.17.2", "l": "\"carboxypeptidase B\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9705584", "l": "HMGCR dimer binds statins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21738", "l": "(3S,5S)-3,5-diaminohexanoate => (3S)-3,6-diaminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013992", "l": "TRAF3 binds to TRIF:activated TLR3 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4093331", "l": "Ras:GTP binds p120-RasGAP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9011983", "l": "Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9674529", "l": "AAMP binds to TBXA2R (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "80.939779364256637", "identifiers": [{"i": "GO:0008318", "l": "protein prenyltransferase activity", "d": ["Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-198732", "l": "STAT3 activation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32106", "l": "2 S-adenosyl-L-methionine + trans-resveratrol <=> 2 H(+) + pterostilbene + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482636", "l": "1-acyl LPS is acylated to PS by LPSAT (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-390593", "l": "ATP Hydrolysis By Myosin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2160915", "l": "Receptor-mediated uptake of HA (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9623059", "l": "FOXO1 binds POMC gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-201422", "l": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6782943", "l": "UV-DDB ubiquitinates XPC (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69925", "l": "brassinolide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => castasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5685607", "l": "Sialic acid binds SIGLEC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8954468", "l": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21174", "l": "5-dehydro-D-gluconate + H(+) + NADH => L-idonate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12798", "l": "(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 => CO2 + H(+) + H2O + scopolamine + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034277", "l": "ent-cassa-12,15-diene synthase activity", "d": ["Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73638", "l": "CTP(out) + dGMP(in) <=> CTP(in) + dGMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66008", "l": "(5R)-5-hydroxy-L-lysyl-[collagen] + H2O2 + L-methionyl-[collagen] = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + H(+) + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6794355", "l": "Homer1,2,3 binds mGluR1a,5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-983194", "l": "Kinesin-1 is a heterotetramer (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31133", "l": "(6S)-5,6,7,8-tetrahydrofolate + 2 H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide => (6R)-5,10-methenyltetrahydrofolate + H2O + N(1)-(5-phospho-beta-D-ribosyl)glycinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19762", "l": "FMN-N(5)-oxide + H(+) + NADH => FMN + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41903", "l": "H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] <=> 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-399712", "l": "Activation of Ca permeable AMPA receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9710295", "l": "IRF2 or IRF1 binds the GSDMD gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5632668", "l": "SMO translocates to the cilium (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23556", "l": "D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH4(+)", "d": [], "t": []}, {"i": "EC:2.3.2.14", "l": "\"D-alanine gamma-glutamyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5099899", "l": "WNT5A binds FZD4 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5682111", "l": "Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-389086", "l": "Autophosphorylation of PDGF alpha/beta receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77365", "l": "5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminohexanoate => 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24101", "l": "diisopropyl fluorophosphate + H2O => diisopropyl phosphate + fluoride + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59334", "l": "1'-hydroxytorulene + AH2 => 1'-hydroxy-gamma-carotene + A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45787", "l": "2 H2O + phenylpropanonitrile <=> 3-phenylpropanoate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5654663", "l": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71921", "l": "3 Na(+)(in) + succinate(in) => 3 Na(+)(out) + succinate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3299753", "l": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71552", "l": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6787329", "l": "PGM2:Mg2+ isomerises R1P to R5P (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47929", "l": "(2S)-3-sulfolactaldehyde + H2O + NADP(+) => (2S)-3-sulfolactate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66462", "l": "14betaH-scalarane-17alpha-19-diol => (2E,6E,10E,14E)-geranylfarnesol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71343", "l": "chloride(out) + L-histidine(out) + 2 Na(+)(out) = chloride(in) + L-histidine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2468039", "l": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2172126", "l": "DAP12 interacts with NKG2C (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54293", "l": "ATP + L-threonyl-[protein] => 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33865", "l": "fumarate + menaquinol-7 => menaquinone-7 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-211178", "l": "Phosphorylated FOXO1A is excluded from the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140860", "l": "(3R)-2'-hydroxyisoflavanone reductase activity", "d": ["Catalysis of the reaction: a (3R,4R)-4,2'-dihydroxyisoflavan + NADP+ = a (3R)-2'-hydroxyisoflavanone + H+ + NADPH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51201", "l": "a 1,2-diacyl-sn-glycero-3-phosphate + H(+) + N-retinylidene-N-retinylethanolamine => H2O + N-retinylidene-N-retinylphosphatidylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48395", "l": "a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + GDP-beta-L-fucose <=> a neolactoside IV(3)-alpha-NeuNAc,III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53417", "l": "8-amino-8-demethylriboflavin + S-adenosyl-L-methionine => 8-demethyl-8-(methylamino)riboflavin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832340", "l": "Expression of LHX1 during nephron development (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5679205", "l": "ULK1 phosphorylates Beclin-1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.99.-.-", "l": "\"Other enzymes using O2 as oxidant\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4570467", "l": "SUMOylation of NOP58 with SUMO1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74712", "l": "Dissociation of IRS-P from insulin receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8869683", "l": "oxPL binds LBP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25225", "l": "L-arabinitol + NAD(+) = H(+) + L-arabinose + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-964737", "l": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5687091", "l": "p-S MAPK6,4 binds MAPKAPK5 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-983147", "l": "Release of E3 from polyubiquitinated substrate (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74986", "l": "Elongation of pre-rRNA transcript (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71449", "l": "D-alanine(out) + Na(+)(out) => D-alanine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8948146", "l": "FUNDC1 is phosphorylated by ULK1 at Ser17 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9611839", "l": "β3-agonists bind ADRB3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74237", "l": "L-threonine + tRNA(Ser) => H2O + L-threonyl-tRNA(Ser)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018486", "l": "2-butanone oxidase activity", "d": ["Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018473", "l": "cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity", "d": ["Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14091", "l": "glyoxylate + L-glutamate => 2-oxoglutarate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78497", "l": "CMP-5'-(N-acetyl-N-hydroxy-3-aminopropyl)phosphonate + CoA => acetyl-CoA + CMP-5'-(N-hydroxy-3-aminopropyl)phosphonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427605", "l": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9657619", "l": "CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1638032", "l": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2730851", "l": "Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8949580", "l": "F1Fo ATP synthase dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8866308", "l": "pre-VLDL translocates from RER membrane to SER lumen (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49932", "l": "(3E,5Z)-octadienoyl-CoA = (2E,5Z)-octadienoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-352158", "l": "SLC16A10-mediated uptake of aromatic amino acids (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8852134", "l": "UBA1 adenylates ubiquitin in the cytosol (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29705", "l": "L-valine(out) => L-valine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-373730", "l": "Neurofascin and NrCAM heterodimerization (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-936986", "l": "Activated TRAF6 synthesizes unanchored polyubiquitin chains (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-76453", "l": "Coumarin is 7-hydroxylated by CYP2A6 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58767", "l": "1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + H(+) + NADPH <=> 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65405", "l": "butan-1-ol + hexanoyl-CoA => butyl hexanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34533", "l": "CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose + H(+) => acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-450394", "l": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034568", "l": "isoproturon dimethylaminedehydrogenase activity", "d": ["Catalysis of the reaction: isoproturon + H2O = formaldehyde + monodemethylisoproturon + 2 H+ + 2 e-."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27300", "l": "2 H(+) + NADH + phthalate => 2-formylbenzoate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44252", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z)-octadecenoyl-3-octadecanoyl-sn-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38725", "l": "(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-3-(9Z)-octadecenoyl-sn-glycerol => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-O-methyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9712274", "l": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1855207", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-382058", "l": "Nck binds to the active PDGF receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62576", "l": "ATP + H2O + L-cystine(out) = ADP + H(+) + L-cystine(in) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54455", "l": "a 5,6-dihydrouridine in tRNA + NAD(+) <=> a uridine in tRNA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202969", "l": "Caspase mediated cleavage of beta-catenin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47405", "l": "(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) => 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004349", "l": "glutamate 5-kinase activity", "d": ["Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080139", "l": "borate efflux transmembrane transporter activity", "d": ["Enables the transfer of borate from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-909721", "l": "Translocation of ISGF3 complex to nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37515", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42322", "l": "a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate => a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53017", "l": "chlorohydroquinone + 2 glutathione => chloride + glutathione disulfide + H(+) + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34970", "l": "sn-glycerol 3-phosphate(in) <=> sn-glycerol 3-phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0015373", "l": "monoatomic anion:sodium symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic anion(out) + Na+(out) = monoatomic anion(in) + Na+(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-446634", "l": "IRAK4 is activated by autophosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68277", "l": "butanoyl-CoA + L-seryl-[protein] => CoA + O-butanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5654623", "l": "Activated FGFR3 binds FRS3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174452", "l": "RFC binding displaces Pol Alpha on the C-strand of the telomere (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29800", "l": "ATP + D-allose(out) + H2O => ADP + D-allose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40358", "l": "1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + ATP <=> 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1299338", "l": "Activation of TRESK (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990943", "l": "mating type region replication fork barrier binding", "d": ["Binding to the replication fork barrier found in the mating type region of fission yeast."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.21.62", "l": "\"subtilisin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41281", "l": "octadecanoate + sphing-4-enine => H2O + N-octadecanoylsphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24688", "l": "formate + methanofuran => H2O + N-formylmethanofuran", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004747", "l": "ribokinase activity", "d": ["Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-390250", "l": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69125", "l": "glyoxylate + L-tryptophan => glycine + indole-3-pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51065", "l": "3'-phosphoadenylyl sulfate + lithocholate => adenosine 3',5'-bisphosphate + H(+) + lithocholate sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788748", "l": "EHMT1:EHMT2 methylates IL6 promoter (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809720", "l": "PI3P is dephosphorylated to PI by MTM1:MTMR12 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10008", "l": "[protein]-dithiol + a hydroperoxide = [protein]-disulfide + an alcohol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9675214", "l": "Formation of the WRAD complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69682", "l": "apigenin 7-O-beta-D-glucoside + H2O <=> apigenin + beta-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62160", "l": "H2O + N-(9Z-octadecenoyl)-ethanolamine phosphate = N-(9Z-octadecenoyl) ethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54663", "l": "an aromatic (S)-hydroxynitrile <=> an aromatic aldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050160", "l": "orsellinate-depside hydrolase activity", "d": ["Catalysis of the reaction: H2O + orsellinate depside = 2 o-orsellinate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45302", "l": "an N-acyl-sphingoid base + H(+) + phosphocholine => an N-(acyl)-sphingosylphosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37071", "l": "[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + S-adenosyl-L-methionine = 2-sulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0042289", "l": "MHC class II protein binding", "d": ["Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15601", "l": "(E)-cinnamoyl-CoA + (R)-3-phenyllactate = (E)-cinnamate + (R)-3-phenyllactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052638", "l": "indole-3-butyrate beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1602466", "l": "Activation of MT-MMPs by FURIN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68147", "l": "ethyl 3-oxobutanoate + H(+) + NADPH <=> ethyl (R)-3-hydroxybutanoate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76035", "l": "(S)-cis-N-methylstylopine + O2 + reduced [NADPH--hemoprotein reductase] = 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + protopine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052735", "l": "tRNA (cytidine-3-)-methyltransferase activity", "d": ["Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = an N3-methylcytidine in tRNA + H+ + S-adenosyl-L-homocysteine."], "t": []}, {"i": "RHEA:60908", "l": "a cytidine in tRNA + S-adenosyl-L-methionine = an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54920", "l": "13-cis-retinol + NADP(+) = 13-cis-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37450", "l": "O2 + tetracenomycin F1 <=> H(+) + H2O + tetracenomycin D3", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58181", "l": "(1R,2R,3R)-prephytoene diphosphate + H(+) + NADPH => all-trans-lycopaoctaene + diphosphate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191299", "l": "Squalene is oxidized to its epoxide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77462", "l": "3-formylthiophene + hydrogen cyanide <=> (2S)-2-hydroxy-2-(thiophen-3-yl)acetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950441", "l": "p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9625813", "l": "S1P binds S1PR3 in response to E2 stimulation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43832", "l": "5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA = 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61409", "l": "ATP + N(6)-(D-erythrulosyl)-L-lysine => ADP + H(+) + N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193696", "l": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4608855", "l": "PRICKLE1 is degraded by the proteasome (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-444100", "l": "PROT mediates L-proline uptake (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41664", "l": "dihydrochelirubine + NAD(+) = chelirubine + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69317", "l": "(Z)-N-(sulfonatooxy)prop-2-enimidothioate => allyl thiocyanate + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-351208", "l": "Spermidine  => N-acetylated spermidine (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8871370", "l": "p-Y389,400-RUFY1 translocates from cytosol to early endosome membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-1675939", "l": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6806966", "l": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6807826", "l": "LDHAL6B reduces PYR to LACT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1482861", "l": "MLCL is acylated to CL by LCLAT1 (ER) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24814", "l": "2-oxoglutarate + L-valine => 3-methyl-2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-198714", "l": "ERK5 translocates to the nucleus (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50044", "l": "an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-200661", "l": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48706", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212713", "l": "Active PLC-gamma1 dissociates from EGFR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0001512", "l": "dihydronicotinamide riboside quinone reductase activity", "d": ["Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40035", "l": "ATP + L-glutamate + N-acetyl-L-aspartate = ADP + H(+) + N-acetyl-L-aspartyl-L-glutamate + phosphate", "d": [], "t": []}, {"i": "EC:6.3.2.41", "l": "\"N-acetylaspartylglutamate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8866941", "l": "MID1IP1 binds THRSP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75125", "l": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666197", "l": "RHOA:GTP:RTKN binds LIN7B (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9632034", "l": "CHSY1 transfers GlcA to chondroitin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56528", "l": "chloride + D-tryptophan + FADH2 + O2 = 6-chloro-D-tryptophan + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42585", "l": "1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O => 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176494", "l": "SULTs transfer (SO4)2- group to 27HCHOL (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9640168", "l": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5626981", "l": "TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-166721", "l": "MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21757", "l": "H2O + N-deacetylisoipecoside => dopamine + secologanin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10529", "l": "dihydrosanguinarine + O2 + reduced [NADPH--hemoprotein reductase] => 10-hydroxydihydrosanguinarine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-990489", "l": "Kinesin-13 is a dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46243", "l": "a (9Z)-hexadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12E)-hexadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "44.377045789078466", "identifiers": [{"i": "GO:0004930", "l": "G protein-coupled receptor activity", "d": ["Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9701000", "l": "BRCA1:BARD1 heterodimer autoubiquitinates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64809", "l": "acetyl-CoA + O-(2-aminoethyl)-L-serine => CoA + H(+) + O-(2-acetamidoethyl)-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37348", "l": "(R)-lactate + ATP + D-alanine => ADP + D-alanyl-(R)-lactate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047717", "l": "imidazoleacetate 4-monooxygenase activity", "d": ["Catalysis of the reaction: H+ + imidazol-4-ylacetate + NADH + O2 = 5-hydroxyimidazole-4-acetate + H2O + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52277", "l": "(6S)-5,6,7,8-tetrahydrofolate + vanillate => (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3,4-dihydroxybenzoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75155", "l": "(2E,6E,10E)-geranylgeranyl diphosphate + H2O = diphosphate + verrucosan-2beta-ol", "d": [], "t": []}, {"i": "EC:4.2.3.208", "l": "\"verrucosan-2beta-ol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17279", "l": "2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O => 6-phospho-D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41904", "l": "3-oxohexadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8875183", "l": "CBL monoubiquitinates activated MET (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8987012", "l": "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2473151", "l": "CDCA5 (Sororin) enables cohesion of sister centromeres (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52894", "l": "H(+) + NADPH + nitrobenzene => H2O + NADP(+) + nitrosobenzene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-389788", "l": "Activation of PAKs by RAC1 and CDC42 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1678920", "l": "TLR processing at low pH (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8952419", "l": "SMURFs ubiquitinate RUNX3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201639", "l": "Caspase-mediated cleavage of GAS2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:7.2.2.3", "l": "\"P-type Na(+) transporter\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6798747", "l": "Exocytosis of tertiary granule membrane proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63111", "l": "16-hydroxy-ilicicolin A epoxide <=> ascofuranol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15507", "l": "2-formylglutarate + H(+) + NADH => (S)-2-hydroxymethylglutarate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70318", "l": "beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol <=> cholesteryl 3-beta-D-glucoside + N-(15Z-tetracosenoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9610163", "l": "BRAF autophosphorylates downstream of RAP1 and NGF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59570", "l": "ADP + H(+) + L-homocarnosine + phosphate => 4-aminobutanoate + ATP + L-histidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.1.99.7", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3222237", "l": "SMYD2 methylates TP53 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952371", "l": "MDM2 binds RUNX3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12455", "l": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61872", "l": "1-O-methyl-(9Z,12Z)-octadecadienoate + O2 = 1-O-methyl-(9R)-hydroperoxy-(10E,12Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5693061", "l": "STAMBP binds STAM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45532", "l": "H2O + N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-(9Z-octadecenoyl) ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9647746", "l": "EML4 trimerizes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15060", "l": "(9Z)-octadecenoyl-[ACP] + H2O <=> (9Z)-octadecenoate + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-6782943", "l": "UV-DDB ubiquitinates XPC (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20565", "l": "(2E)-geranyl diphosphate + H2O = (1S,2S,4R)-endo-fenchol + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.10", "l": "\"(-)-endo-fenchol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37839", "l": "1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050297", "l": "stizolobate synthase activity", "d": ["Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16293", "l": "2-isopropylmaleate + H2O = (2S)-2-isopropylmalate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-201035", "l": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21078", "l": "CO2 + succinate + uridine => 2'-deoxyuridine + 2-oxoglutarate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25686", "l": "H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) = L-cysteinyl-tRNA(Cys) + phosphate", "d": [], "t": []}, {"i": "EC:2.5.1.73", "l": "\"O-phospho-L-seryl-tRNA:Cys-tRNA synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63350", "l": "(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline-[protein] + ADP + H(+) + phosphate => ATP + L-amino acyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433711", "l": "Cis-homodimerization of nectins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-179467", "l": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086038", "l": "calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39795", "l": "7beta-hydroxycholesterol(in) + ATP + H2O = 7beta-hydroxycholesterol(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8853800", "l": "ARTN binds RET:GFRA1,GFRA3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140441", "l": "protein-cysteine S-arachidonoyltransferase activity", "d": ["Catalysis of the transfer of an arachidonoyl (systematic name, (5Z,8Z,11Z,14Z)-eicosatetraenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: in the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]."], "t": []}, {"i": "RHEA:59748", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71723", "l": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-381158", "l": "ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.26", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654647", "l": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989766", "l": "Expression of CTGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209868", "l": "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0022850", "l": "serotonin-gated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35330", "l": "eicosanoyl-CoA + H(+) + malonyl-CoA <=> 3-oxodocosanoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5244669", "l": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46315", "l": "3-oxochol-4-en-22-oyl-CoA + acetyl-CoA <=> 3,22-dioxochol-4-en-24-oyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4641350", "l": "PIAS4 SUMOylates TOP2A with SUMO2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9014627", "l": "SDS dimers:PXLP dehydrate L-Thr to 2AA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8874979", "l": "ACBD3 binds GOLGB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28945", "l": "glycine betaine(out) => glycine betaine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1901604", "l": "dethiobiotin transmembrane transporter activity", "d": ["Enables the transfer of dethiobiotin from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5649799", "l": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75495", "l": "n H(+)(out) + pregnenolone sulfate(out) = n H(+)(in) + pregnenolone sulfate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.181", "l": "\"hydroxyanthraquinone glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9756183", "l": "UGT1A3 lactonizes 4-OH-ATV to 4-OH-ATVL (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036319", "l": "mating-type M-factor pheromone receptor activity", "d": ["Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58226", "l": "5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide => L-glutamyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5683077", "l": "RNF8 and RNF168 ubiquitinate KDM4A,B (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66649", "l": "(2E,6E)-farnesyl diphosphate => african-3-ene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59253", "l": "(E)-3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate => (E)-3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14571", "l": "H2O + propanal => propane-1,2-diol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12329", "l": "[(1->3)-alpha-D-glucosyl](n) + phosphate => [(1->3)-alpha-D-glucosyl](n-1) + beta-D-glucose 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23816", "l": "2-oxoglutarate + putrescine = 4-aminobutanal + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-71299", "l": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-453111", "l": "Phosphorylated SHC recruits GRB2:SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696838", "l": "BHMT2 tetramer transfers CH3 group from SMM to LHCYS (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26430", "l": "(+)-copalyl diphosphate + H2O = diphosphate + phyllocladan-16alpha-ol", "d": [], "t": []}, {"i": "EC:4.2.3.45", "l": "\"phyllocladan-16alpha-ol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21701", "l": "5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021948", "l": "GPRIN1 gene expression is stimulated by MECP2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050188", "l": "phosphoenolpyruvate mutase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3296301", "l": "CCRL2 binds CCL19 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75097", "l": "Transport of the export-competent mRNP complex through the NPC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46378", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin] => a (9Z)-octadecenoyl-containing glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1222685", "l": "Cathelicidin LL-37 binds to bacterial cell wall (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9031610", "l": "p-S133 CREB1, MEF2D and SRF  bind the ARC gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59061", "l": "(20S)-ginsenoside Rg3 + H2O => (20S)-ginsenoside Rh2 + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9020273", "l": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036173", "l": "thiosulfate binding", "d": ["Binding to a thiosulfate, a sulfur oxide that has formula O3S2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197186", "l": "NAPRT1 dimer transfers PRIB to NCA to form NAMN (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.25", "l": "\"saccharopepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36559", "l": "A + cis-4-hydroxy-D-proline = 4-hydroxy-1-pyrroline-2-carboxylate + AH2 + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004742", "l": "dihydrolipoyllysine-residue acetyltransferase activity", "d": ["Catalysis of the reaction: (R)-N6-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N6-(S8-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45666", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate => 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-188544", "l": "Assembly of M2 tetramers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9664273", "l": "SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11256", "l": "H2O + limonin + UDP-alpha-D-glucose = glucosyl-limonin + 2 H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.210", "l": "\"limonoid glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78820", "l": "2-oxoglutarate + L-arginine => 5-guanidino-2-oxopentanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008597", "l": "calcium-dependent protein serine/threonine phosphatase regulator activity", "d": ["Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase."], "t": []}, {"i": "REACT:R-HSA-139906", "l": "Activation of BAD by calcineurin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3322424", "l": "Beta-catenin recruits CDC73 and LEO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-433101", "l": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60180", "l": "ATP + D-fructose(out) + H2O = ADP + D-fructose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-443910", "l": "SHC1 dissociates from integrin alphaIIb beta3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1169406", "l": "ISGylation of host proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62175", "l": "an N-acylethanolamine phosphate + H2O <=> an N-acylethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22829", "l": "1-(5-phospho-beta-D-ribosyl)-ATP + H2O => 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68365", "l": "4-CDP-2-C-methyl-D-erythritol => 2-C-methyl-D-erythritol 3,4-cyclophosphate + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209125", "l": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2744349", "l": "TTYH1 transports cytosolic Cl- to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8956031", "l": "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11859", "l": "1D-myo-inositol 1,4,5,6-tetrakisphosphate + ATP <=> 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57088", "l": "an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = 3-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-4641159", "l": "DVL1 is ubiquitinated by HECW1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4411373", "l": "NLK translocates to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12942", "l": "N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine => H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5618080", "l": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-914005", "l": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65467", "l": "2-methylbutan-1-ol + butanoyl-CoA <=> 2-methylbutyl butanoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63781", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine => 1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79136", "l": "L-alanine + taurocholate => L-alanocholate + taurine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19248", "l": "N-phenylhydroxylamine <=> 2-aminophenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013145", "l": "RAC1 binds effectors at the plasma membrane (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55578", "l": "H(+) + psilocybin + S-adenosyl-L-homocysteine => 4-hydroxy-N-methyltryptamine 4-phosphate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35470", "l": "(6S)-5,6,7,8-tetrahydrofolate + S,S-dimethyl-beta-propiothetin <=> (6S)-5-methyl-5,6,7,8-tetrahydrofolate + 3-(methylsulfanyl)propanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432507", "l": "Cytosolic TIM is degraded by the 26S proteasome (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15838", "l": "L-glutamate + methylamine => N-methyl-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983063", "l": "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5617179", "l": "PRKACA phosphorylates TNNI3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43896", "l": "3beta-hydroxy-5alpha-androstan-17-one + O2 + reduced [NADPH--hemoprotein reductase] = 3beta,7alpha-dihydroxy-5alpha-androstan-17-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46382", "l": "(24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 7alpha-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-927789", "l": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76222", "l": "GDP(in) <=> GDP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-437162", "l": "PI3K alpha, beta, gamma convert PIP2 to PIP3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40768", "l": "(20S)-ginsenoside R1 + H2O => (20S)-ginsenoside Rg1 + D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27772", "l": "2-methoxy-6-(all-trans-octaprenyl)phenol + H(+) + S-adenosyl-L-homocysteine => 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9750656", "l": "ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-352052", "l": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-209178", "l": "N-HH binds to PTC receptor complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54007", "l": "(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O <=> (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8877192", "l": "RUNX1 binds FOXP3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3697894", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-376851", "l": "SLC25A11 exchanges 2-OG and MAL (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65459", "l": "2-methylbutan-1-ol + acetyl-CoA <=> 2-methylbutyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856630", "l": "CIDEA:CIDEC binds lipid droplets (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9825772", "l": "SIRT1 deacetylates HINT1 dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32325", "l": "ent-kaur-16-en-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => ent-kaur-16-ene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2162187", "l": "COQ6 hydroxylates DHB (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66630", "l": "(2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2 => (2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48168", "l": "H2O + N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine = N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-(octadecanoyl)-sphing-4-enine + N-acetylneuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58819", "l": "ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018625", "l": "naphthalene 1,2-dioxygenase activity", "d": ["Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19654", "l": "CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + H2O + NAD(+) => CDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62732", "l": "(+)-isomalbrancheamide B + bromide + FAD + 2 H(+) = (+)-isomalbrancheamide D + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-981713", "l": "C4b binds to cell surface (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5692261", "l": "ALDH3A2-1 oxidises HD2NAL to PALM (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37313", "l": "ADP + glycyl-L-glutamine(in) + H(+) + phosphate => ATP + glycyl-L-glutamine(out) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24373", "l": "H2O + N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] => H(+) + N(4)-[6-phospho-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49143", "l": "dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] <=> dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71696", "l": "2 H(+)(out) + L-alanyl-L-aspartate(out) => 2 H(+)(in) + L-alanyl-L-aspartate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3769394", "l": "AKT phosphorylates CBY1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1614605", "l": "Persulfide sulfur is dioxygenated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-199216", "l": "SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482547", "l": "1-acyl LPC is acylated to PC by LPCAT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63969", "l": "2 3-(4-hydroxyphenyl)pyruvate + H(+) => atromentin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5419165", "l": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60909", "l": "a cytidine in tRNA + S-adenosyl-L-methionine => an N(3)-methylcytidine in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-192422", "l": "Digestion of triacylglycerols by extracellular PTL:colipase (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5653878", "l": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40016", "l": "(+)-copalyl diphosphate + H2O => 13-epi-manool + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42701", "l": "6-carboxyhexanoyl-[ACP] methyl ester + H2O => 6-carboxyhexanoyl-[ACP] + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-873926", "l": "IFNG dimer binds IFNGR (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32151", "l": "9alpha-copalyl diphosphate = (12E)-9alpha-labda-8(17),12,14-triene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.99", "l": "\"labdatriene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0090588", "l": "protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylmuramate (out) = protein cysteine + N-acetylmuramate-6-phosphate (in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-199298", "l": "AKT phosphorylates CREB1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2562594", "l": "Phosphorylated OPTN translocates to the nucleus (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74484", "l": "(Z)-dehydrocyclopeptine + 2-oxoglutarate + O2 => (-)-cyclopenine + CO2 + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21219", "l": "ATP + D-ribose 5-phosphate <=> ADP + alpha-D-ribose 1,5-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76048", "l": "(S)-tetrahydropalmatine + S-adenosyl-L-methionine => (S)-cis-N-methyltetrahydropalmatine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33752", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O => 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77464", "l": "furan-3-carbaldehyde + hydrogen cyanide => (2S)-2-(furan-3-yl)-2-hydroxyacetonitrile", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696230", "l": "GSTO1 dimer reduces methylarsonate to methylarsonite (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2106615", "l": "Removal of siRNA passenger strand (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9622738", "l": "CAT gene expression is stimulated by FOXO3,FOXO6,(FOXO1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2243931", "l": "Formation of dehydro-lysinonorleucine cross-links (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10070", "l": "4-O-[(2-beta-D-glucosyl-D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP => 4-O-[(D-ribitylphospho)(n)-D-ribitylphospho-(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23271", "l": "guanidinoacetate + H2O <=> glycine + urea", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8877003", "l": "CBLL1 ubiqutinates the InlA-bound CDH1 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1918095", "l": "CUL5 mediates ubiquitination of ERBB2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3299569", "l": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11781", "l": "3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-galactose => 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015514", "l": "nitrite efflux transmembrane transporter activity", "d": ["Enables the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199895", "l": "RSK1/2/3 phosphorylates CREB at Serine 119 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8981553", "l": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50188", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.23.20", "l": "\"penicillopepsin\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-375133", "l": "Basigin binds Mannose-carrying cell recognition molecules (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34944", "l": "hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) => arbutin 6-phosphate(in) + pyruvate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54535", "l": "H2O + N-(4-oxoglutaryl)-L-cysteinylglycine <=> 2-oxoglutarate + L-cysteinylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56631", "l": "5-chlorocarbonyl-4-hydroxy-penta-2,4-dienoate + H2O <=> chloride + 2 H(+) + maleylacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61292", "l": "(R)-pantoate + NAD(+) = 2-dehydropantoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849878", "l": "PSD-95 binds NMDA receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3772430", "l": "CTNNBIP1 binds beta-catenin (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30094", "l": "a ubiquinone + D-alanine + H2O <=> a ubiquinol + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102168", "l": "5-methyl-phenazine-1-carboxylate N-methyltransferase activity", "d": ["Catalysis of the reaction: phenazine-1-carboxylate + S-adenosyl-L-methionine = 5-methylphenazine-1-carboxylate + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44823", "l": "1,4-dihydroxy-2-naphthoate + all-trans-tridecaprenyl diphosphate + H(+) <=> 2-demethylmenaquinol-13 + CO2 + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482543", "l": "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76115", "l": "2-oxoglutarate + O2 + thebaine = 6-O-demethylthebaine + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "85.510657888247053", "identifiers": [{"i": "GO:0051427", "l": "hormone receptor binding", "d": ["Binding to a receptor for a hormone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40839", "l": "FAD + H(+) + nonanoyl-CoA = (2E)-nonenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080103", "l": "4-methylthiopropyl glucosinolate S-oxygenase activity", "d": ["Catalysis of the reaction: 4-methylthiopropyl-glucosinolate = 4-methylsulfinylpropyl-glucosinolate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61316", "l": "germacra-1(10),4,11(13)-trien-12-al + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72022", "l": "2-oxoglutarate + H(+) + O2 + trihazone A <=> 2 CO2 + H2O + succinate + trihazone D", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9817397", "l": "TBK1, IKBKE phosphorylate RIPK1 at T189 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38080", "l": "2-(9Z-octadecenoyl)-glycerol + eicosanoyl-CoA => 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41146", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O <=> 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.21", "l": "\"squalene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-201622", "l": "Caspase-mediated cleavage of gelsolin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67320", "l": "(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate = sch 210971", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18294", "l": "ATP + CoA + oxalate => AMP + diphosphate + oxalyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.2.1.167", "l": "\"baicalin-beta-D-glucuronidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9020616", "l": "ATG12 forms a thioester bond with ATG7 dimer (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73677", "l": "ADP(in) + dAMP(out) + H(+)(in) => ADP(out) + dAMP(in) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44167", "l": "ATP + H2O <=> adenine + D-ribose 5-triphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2514854", "l": "CDK1 phosphorylates condensin I (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654147", "l": "Activated FGFR2 phosphorylates PLCG1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18749", "l": "[protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218824", "l": "p-6Y-VEGFR2 binds FYN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4641205", "l": "RSPO:LGR binds ZNRF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8851888", "l": "MET binds SHC1-2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58639", "l": "N-(9Z-octadecenoyl)-(2S)-hydroxyglycine <=> (9Z)-octadecenamide + glyoxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-425483", "l": "SLC4A5,7,9 cotransport Na+ with 3HCO3- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046265", "l": "B4GALTs transfer Gal to the keratan chain (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8957389", "l": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18895", "l": "a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + H(+) + UDP => a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77681", "l": "a globoside DSGG (d18:1(4E)) + CMP + H(+) => a globoside MSGG (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50271", "l": "(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate <=> (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8952807", "l": "p-Y693-STAT4 dissociates after IL12:IL12R interaction (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-193073", "l": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2426471", "l": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-197271", "l": "NADSYN1 hexamer amidates NAAD to NAD+ (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6791222", "l": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21294", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+) => a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76767", "l": "emodin + S-adenosyl-L-methionine = physcion + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018807", "l": "6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity", "d": ["Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-353476", "l": "Recruitment of repair factors to form the preincision complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508561", "l": "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59247", "l": "3''-O-acetyl-ADP-D-ribose + H2O <=> acetate + ADP-D-ribose + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8853734", "l": "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-427337", "l": "MBD2 binds methylcytosine in chromatin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16932", "l": "2 benzoyl-CoA + L-ornithine <=> 2 CoA + 2 H(+) + N(2),N(5)-dibenzoyl-L-ornithine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-74993", "l": "PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-992703", "l": "Mitofusins trans-interact linking mitochondria prior to fusion (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74759", "l": "isorhamnetin + S-adenosyl-L-methionine = 3,3'-O-dimethylquercetin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-166795", "l": "Formation of Classical C3 convertase (C4b:C2a complex) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5082384", "l": "HSP70:DNAJB1 binds HSF1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8934465", "l": "SHC1 binds PTPN12 (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4719423", "l": "PIAS2-2 SUMOylates THRA with SUMO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13025", "l": "3-methyl-(2E)-butenoyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = 3-methyl-(2E)-glutaconyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57032", "l": "(E)-2-((N-methylformamido) methylene)succinate + H(+) + 2 H2O = CO2 + formate + methylamine + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5229343", "l": "AXIN is phosphorylated in the destruction complex (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9688459", "l": "RIPK3 binds HSP90:CDC37 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28643", "l": "(2E,6E)-farnesyl diphosphate = alpha-zingiberene + diphosphate", "d": [], "t": []}, {"i": "EC:4.2.3.65", "l": "\"zingiberene synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849900", "l": "SALMs1-3 bind each other in cis interactions (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3002811", "l": "Myosin phosphatase dephosphorylates PLK1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47176", "l": "(2R)-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24700", "l": "7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + a 1,2-diacyl-sn-glycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45598", "l": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4420128", "l": "SRC-1 phosphorylates SHB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46629", "l": "3beta-hydroxyandrost-5-en-17-one + H(+) + NADPH => androst-5-en-3beta,17beta-diol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5218822", "l": "CRK binds BCAR1 and or PXN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8982021", "l": "G alpha (z) in G alpha (z):RGS complex is inactivated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21313", "l": "2,5-dihydroxybenzoate + H(+) => CO2 + hydroquinone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23781", "l": "H2O + oxaloacetate + propanoyl-CoA => (2S,3S)-2-methylcitrate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54728", "l": "acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}, {"i": "EC:2.1.3.15", "l": "\"acetyl-CoA carboxytransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31829", "l": "(+)-gamma-cadinene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8863723", "l": "COP9 and TOR1 deneddylate STON2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928641", "l": "PAK binds RAC and bPIX (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5696074", "l": "AGK:Mg2+ phosphorylates MAG, DAG (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34025", "l": "(E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH => 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-452091", "l": "Phosphorylation of IL2RB Y338 enables SHC recruitment (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5694018", "l": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54789", "l": "[LarE protein]-L-cysteine + ATP + pyridinium-3,5-dicarboxylate mononucleotide => [LarE protein]-dehydroalanine + AMP + diphosphate + H(+) + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4551655", "l": "CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1250346", "l": "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49465", "l": "2,6-dihydroxybenzoate + H(+) => CO2 + resorcinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21524", "l": "3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)", "d": [], "t": []}, {"i": "EC:2.3.3.13", "l": "\"2-isopropylmalate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.279", "l": "\"trans-anol O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18401", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = (S)-4-hydroxymandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.37", "l": "\"4-hydroxyphenylacetaldehyde oxime monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5669097", "l": "LTA trimer binds TNFRSF1A,1B,14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16909", "l": "2 Fe(III)-[cytochrome c] + glycine + H2O = 2 Fe(II)-[cytochrome c] + glyoxylate + 2 H(+) + NH4(+)", "d": [], "t": []}, {"i": "EC:1.4.2.1", "l": "\"glycine dehydrogenase (cytochrome)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42390", "l": "beta-D-gentiobiosyl crocetin + H(+) + UDP => beta-D-glucosyl crocetin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49037", "l": "(-)-pluviatolide + S-adenosyl-L-methionine => (-)-bursehernin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-74242", "l": "PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8876191", "l": "RAB9 GEFs exchange GTP for GDP on RAB9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22439", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9670413", "l": "JAK2 binds to p-KIT mutants (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47804", "l": "epothilone C + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = epothilone A + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43437", "l": "coproporphyrinogen III + 3 O2 => coproporphyrin III + 3 H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43920", "l": "(25R)-3-oxocholest-4-en-26-al + H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = (25R)-3-oxocholest-4-en-26-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2032794", "l": "WWTR1 (TAZ), TBX5, and PCAF form a complex (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-428750", "l": "Gq activation by TP receptor (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102950", "l": "indole-3-acetyl-valine synthetase activity", "d": ["Catalysis of the reaction: indole-3-acetate + L-valine + ATP = H+ + indole-3-acetyl-valine + AMP + diphosphoric acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8936621", "l": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46083", "l": "(2E)-tetracosenoyl-CoA + H(+) + NADH <=> NAD(+) + tetracosanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77263", "l": "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61453", "l": "H(+) + NADPH + O2 + oxytetracycline => 11a-hydroxy-oxytetracycline + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2176416", "l": "NEDD4L ubiquitin ligase binds SMAD7 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47555", "l": "glycodeoxycholate + H2O <=> deoxycholate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12763", "l": "3 H(+) + precorrin-4 + S-adenosyl-L-homocysteine => precorrin-3B + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.6.6.4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54321", "l": "a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784006", "l": "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029473", "l": "Branching and elongation of mother and daughter filaments (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8938121", "l": "SERPINB13 binds CTSK (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14514", "l": "ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine => ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9647987", "l": "FNTB inhibitors bind FNTA:FNTB (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32464", "l": "glycine + 2 S-adenosyl-L-methionine => 2 H(+) + N,N-dimethylglycine + 2 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53259", "l": "lathosterol + O2 + reduced [NADPH--hemoprotein reductase] <=> 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109291", "l": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2262775", "l": "Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77631", "l": "(9Z)-octadecenoyl-CoA + 1-tetradecanoylglycerol = 1-tetradecanoyl-3-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66849", "l": "2 Cu(2+) + NADH => 2 Cu(+) + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67613", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O => a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61416", "l": "(S)-8-oxocitronellyl enol = cis-trans-nepetalactol", "d": [], "t": []}, {"i": "EC:5.5.1.34", "l": "\"(+)-cis,trans-nepetalactol synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54963", "l": "ATP + CoA + dinor-OPDA <=> AMP + dinor-OPDA-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804242", "l": "TP53 binds the complex of JMY, EP300 and TTC5 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17261", "l": "an aryl sulfate + H2O = a phenol + H(+) + sulfate", "d": [], "t": []}, {"i": "EC:3.1.6.1", "l": "\"arylsulfatase (type I)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015394", "l": "uridine:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8933328", "l": "LYPLA2 hydrolyses PALM-C3,4-GAP43 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75168", "l": "CTP + NAD(+) => CDP + H(+) + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-77277", "l": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9610153", "l": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75079", "l": "Formation of AT-AC C complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-426240", "l": "DAG kinase produces phosphatidic acid from DAG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41535", "l": "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 <=> (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 3-hydroxy-L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684321", "l": "nsp3 cleaves nsp1-4 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8867756", "l": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20104", "l": "a long-chain fatty acid + ATP + L-cysteinyl-[protein] <=> AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61496", "l": "an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-727740", "l": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6805981", "l": "HMGB1 release from cells (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6797630", "l": "LRPP4(LRPP1-3,5) hydrolyse LPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37116", "l": "sphing-4-enine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoyl-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9755030", "l": "ITPA dimer dephosphorylates RBV-TP to RBV-MP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983059", "l": "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-75864", "l": "Newly Formed Phosphodiester Bond Stabilized and PPi Released (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8850846", "l": "NTPDase1 hydrolyzes nucleoside triphosphates (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1605768", "l": "NEU3 cleaves GM3 to form LacCer (plasma membrane) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18543", "l": "dihydrochelirubine + H(+) + S-adenosyl-L-homocysteine => 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17843", "l": "H(+) + O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP => trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5333608", "l": "GSSebGalNac is reduced and methylated to MeSebGalNac (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57010", "l": "2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + H2O + NAD(+) => 5,5'-dehydrodivanillate + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5690740", "l": "CD22 binds B-cell receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30771", "l": "guanosine + H2O = D-ribose + guanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9851062", "l": "AcK685 pY705,S727 STAT3 binds the MIR21 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482867", "l": "DLCL is acylated to MLCL by LCLAT1 (ER) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33072", "l": "D-glucose 6-phosphate => 2-deoxy-L-scyllo-inosose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1470009", "l": "Phosphorylation of STATs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47509", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADH => isolithocholate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57690", "l": "cob(II)inamide-[corrinoid adenosyltransferase] => apo-[corrinoid adenosyltransferase] + cob(II)inamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9692809", "l": "CDC42 binds effectors at the ER membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40230", "l": "3'-phosphoadenylyl sulfate + desulfo-A47934 <=> A47934 + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.14.159", "l": "\"dolabradiene monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098606", "l": "selenocystathionine gamma-lyase activity", "d": ["Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.112", "l": "\"anthocyanidin reductase [(2S)-flavan-3-ol-forming]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49178", "l": "12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H(+) + S-adenosyl-L-homocysteine => 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1483087", "l": "PI is exchanged with PC by PITPNB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33733", "l": "a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin => 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36170", "l": "a 2'-deoxyribonucleoside 5'-phosphate + H2O <=> a 2'-deoxyribonucleoside + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43250", "l": "1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + phosphate => 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9757578", "l": "ALB binds PREDN (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194689", "l": "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52431", "l": "12-oxo-leukotriene B4 + H(+) + NADH <=> 12-oxo-(5S)-hydroxy-(6Z,8E,14Z)-eicosatrienoate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23403", "l": "7,8-dihydroxykynurenate + O2 <=> 5-(3-carboxy-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24360", "l": "2 H(+) + siroheme = Fe(2+) + sirohydrochlorin", "d": [], "t": []}, {"i": "EC:4.99.1.4", "l": "\"sirohydrochlorin ferrochelatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44474", "l": "1-O-alkyl-3-acylglycerol + a monoacyl-sn-glycero-3-phosphocholine => 1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11554", "l": "1-O-alkyl-sn-glycerol + acetate + H(+) => a 1-O-alkyl-2-acetyl-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57790", "l": "4-nitrocatechol + H(+) + NAD(+) + nitrite => 1,3-dinitrobenzene + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32617", "l": "(6E)-8-oxogeranial + H(+) + NADPH => (6E)-8-oxogeraniol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-200644", "l": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67238", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA => mycophenolyl-CoA + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8959571", "l": "LC3 binds the autophagosome membrane Atg5-Atg12 complex (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57941", "l": "Fe-coproporphyrin III + H(+) + H2O2 => CO2 + 2 H2O + harderoheme III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30267", "l": "2 monodehydro-L-ascorbate radical = L-ascorbate + L-dehydroascorbate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3857336", "l": "CEBPB homodimerization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70463", "l": "2-oxoglutarate + a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O + O2 = a 2'-deoxyadenosine in double-stranded DNA + CO2 + glyoxal + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051059", "l": "NF-kappaB binding", "d": ["Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30830", "l": "UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043852", "l": "monomethylamine methyltransferase activity", "d": ["Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19581", "l": "N(6)-dimethylallyladenine + S-adenosyl-L-methionine = discadenine + H(+) + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.5.1.24", "l": "\"discadenine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102805", "l": "codeine O-demethylase activity", "d": ["Catalysis of the reaction: codeine + 2-oxoglutarate + O2 = morphine + formaldehyde + succinate + carbon dioxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34722", "l": "15-methylhexadecasphing-4-enine 1-phosphate <=> (2E)-13-methyltetradecenal + phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66975", "l": "alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP-beta-L-rhamnose <=> alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + dTDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928646", "l": "EPHAs bind EFNAs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-418850", "l": "Activation of Cdc42 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47214", "l": "2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8862733", "l": "CCR2, CCR3 bind CCL13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-174124", "l": "Dephosphorylation of phospho-Cdh1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17714", "l": "(R)-reticuline + O2 + reduced [NADPH--hemoprotein reductase] => H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + salutaridine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388503", "l": "Oxytocin receptor bind oxytocin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24118", "l": "(S)-linalool + diphosphate => (2E)-geranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69846", "l": "a 5,6-dihydrouridine in RNA + NAD(+) <=> a uridine in RNA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-169904", "l": "C3G stimulates nucleotide exchange on Rap1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875443", "l": "USP8 deubiquitinates LRIG1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-382061", "l": "Extracellular processing of novel PDGFs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47420", "l": "A + glutaryl-CoA = (2E)-glutaconyl-CoA + AH2", "d": [], "t": []}, {"i": "EC:1.3.99.32", "l": "\"glutaryl-CoA dehydrogenase (acceptor)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2029451", "l": "Activation of RAC1 by VAV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0042356", "l": "GDP-4-dehydro-D-rhamnose reductase activity", "d": ["Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6786293", "l": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-426032", "l": "DAG is metabolized by DAGL to 2-AG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-444498", "l": "Thyrotropin-releasing hormone receptor binds thyrotropin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34758", "l": "H2O + N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine <=> D-glucose + N-acyl-15-methylhexadecasphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44498", "l": "2-(acylamino)ethyl fatty acid + a monoacyl-sn-glycero-3-phosphocholine => a 1,2-diacyl-sn-glycero-3-phosphocholine + an N-acylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69946", "l": "6alpha-hydroxytyphasterol + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] + typhasterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8870332", "l": "PTPN13:PLEKHA1,2 bind PI(3,4)P2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58434", "l": "(E)-4-oxonon-2-enal + H(+) + NADPH => (E)-4-oxonon-2-en-1-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0003912", "l": "DNA nucleotidylexotransferase activity", "d": ["Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-392835", "l": "Rap1 sequesters Raf1 to inhibit ERK cascade (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5684862", "l": "SFTPB,C, PC, PG translocate from lamellar body to extracellular region. (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109702", "l": "PDPK1 phosphorylates AKT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102580", "l": "cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity", "d": ["Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose = cyanidin 3-O-beta-D-sambubioside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.363", "l": "\"glucose-6-phosphate dehydrogenase [NAD(P)(+)]\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73856", "l": "5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose => 5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-451418", "l": "Pellino ubiquitinates IRAK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71901", "l": "H(+) + N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide => 3',5'-cyclic GMP + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190141", "l": "ALAD binds to Pb2+ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-210430", "l": "Release of L-Glutamate at the synapse (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67874", "l": "3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + H(+) + UDP => 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32443", "l": "all-trans-zeaxanthin + 4 H(+) + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}, {"i": "EC:1.14.15.21", "l": "\"zeaxanthin epoxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0061486", "l": "high-affinity fructose transmembrane transporter activity", "d": ["Enables the transfer of fructose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42348", "l": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5683593", "l": "ATG7:ATG3:LC3 dissociates (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140360", "l": "cyclic-GMP-AMP transmembrane transporter activity", "d": ["Enables the transfer of cyclic-GMP-AMP from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744228", "l": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-162683", "l": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6810376", "l": "ING2 binds PI5P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76821", "l": "H(+) + NADH + NH4(+) + oxaloacetate => D-aspartate + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5649725", "l": "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43445", "l": "1,2-ditetradecanoyl-sn-glycerol + ATP => 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.89", "l": "\"Pro-Pro endopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-77589", "l": "Recognition of AAUAAA sequence by CPSF (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-109415", "l": "AMP + H2O => adenosine + orthophosphate [NT5C1B] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29354", "l": "Zn(2+)(in) <=> Zn(2+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36986", "l": "(14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + H(+) + malonyl-CoA <=> 3-oxo-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.49", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6799097", "l": "ATM phosphorylates ZNF420 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23112", "l": "6-methylsalicylate + H(+) = 3-methylphenol + CO2", "d": [], "t": []}, {"i": "EC:4.1.1.52", "l": "\"6-methylsalicylate decarboxylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2028651", "l": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77747", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacylglycerol = a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71335", "l": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6800434", "l": "Exocytosis of ficolin-rich granule lumen proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8863013", "l": "CDK5 binds p25 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-442661", "l": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-176116", "l": "Recruitment and activation of Chk1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-174110", "l": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607732", "l": "K63polyUb-TAK1 autophosphorylates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-72722", "l": "eIF2 activation (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5665751", "l": "CDC42:GTP:FMNL2 binds Profilin:G-actin (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53406", "l": "13-hydroxy-(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate => (15R)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9753283", "l": "ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-430308", "l": "PARVB interacts with Alpha-actinin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990889", "l": "H4K20me3 modified histone binding", "d": ["Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-200682", "l": "Mitochondrial FPGS-1 transforms THF to THFPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42864", "l": "norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + norspermine + S-methyl-5'-thioadenosine", "d": [], "t": []}, {"i": "EC:2.5.1.126", "l": "\"norspermine synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088218", "l": "Tetrastatin binds integrin alphaVbeta3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5357831", "l": "CHUK, IKBKB phosphorylate CYLD at S418 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65589", "l": "(-)-casbene + O2 + reduced [NADPH--hemoprotein reductase] => 4-hydroxycasbene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4396347", "l": "NOTCH1 Coactivator Complex binds HES1 promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50171", "l": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 <=> N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.22.1.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-211929", "l": "CYP2C19 5-hydroxylates omeprazole (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41472", "l": "ent-sandaracopimaradien-3beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oryzalexin D + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}, {"i": "EC:1.14.14.123", "l": "\"oryzalexin D synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61851", "l": "cholesterol + UDP-alpha-D-glucose <=> cholesteryl 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30649", "l": "CDP-1L-myo-inositol + diphosphate => 1D-myo-inositol 3-phosphate + CTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9695890", "l": "SPNS2,MFSD2B transport S1P from cytosol to extracellular region (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050219", "l": "prostaglandin-A1 delta-isomerase activity", "d": ["Catalysis of the reaction: prostaglandin A1 = prostaglandin C1."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2025724", "l": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3322005", "l": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21375", "l": "H(+) + H2O + urethane <=> CO2 + ethanol + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48816", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8852133", "l": "UBA1 conjugates ubiquitin to UBA1 in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39619", "l": "(2E,14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontaheptaenoyl-CoA + H(+) + NADPH = (14Z,17Z,20Z,23Z,26Z,29Z)-dotriacontahexaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9011748", "l": "IL9R binds JAK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-975903", "l": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64140", "l": "an N-(fatty acyl)-L-asparagine + H2O = a fatty acid + L-asparagine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54575", "l": "a uridine in tRNA <=> a pseudouridine in tRNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32951", "l": "sucrose = trehalulose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1306972", "l": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65517", "l": "5-[(4-hydroxyphenyl)methyl]-3-imino-4,4-dimethylpyrrolidin-2-one + H(+) + H2O => NH4(+) + pre-mycofactocin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5362441", "l": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9617595", "l": "SGTA binds mislocalized membrane protein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0015551", "l": "3-hydroxyphenyl propanoate transmembrane transporter activity", "d": ["Enables the transfer of 3-hydroxyphenyl propanoate from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69094", "l": "2 H(+) + NADH + pentanoate => H2O + NAD(+) + pentanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-352364", "l": "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-72622", "l": "Release of eIF4E from the inactive eIF4E:4E-BP complex  (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-909722", "l": "Release of p-STAT2:p-STAT1 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64829", "l": "3-hydroxybenzyl alcohol + acetyl-CoA => 3-hydroxy-benzyl acetate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8983878", "l": "p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928616", "l": "Activated ROCK phosphorylates MRLCs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73674", "l": "ADP(out) + diphosphate(in) <=> ADP(in) + diphosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-432706", "l": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0033549", "l": "MAP kinase phosphatase activity", "d": ["Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56792", "l": "2 cob(II)alamin-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)alamin-[corrinoid adenosyltransferase] + 3 H(+) + oxidized [electron-transfer flavoprotein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5679239", "l": "ULK complex translocates to the ER (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35571", "l": "(1'S)-averantin + O2 + reduced [NADPH--hemoprotein reductase] = (1'S,5'S)-5'-hydroxyaverantin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20227", "l": "(E)-ferulate + H(+) + S-adenosyl-L-homocysteine => (E)-caffeate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9749215", "l": "MCM8 binds CDC6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36281", "l": "3-methylxanthine + formaldehyde + H2O + NAD(+) => H(+) + NADH + O2 + theophylline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69973", "l": "(22S)-22-hydroxycampest-4-en-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => (22S)-22-hydroxycampesterol + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-380927", "l": "p-AMPK phosphorylates TSC1:TSC2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44713", "l": "a 1,2-diacylglycerol + H2O => a 1-acylglycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9817575", "l": "ERO1B oxidizes P4HB (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103004", "l": "9,10-epoxystearate hydroxylase activity", "d": ["Catalysis of the reaction: H+ + 9,10-epoxystearate + O2 + NADPH = 9,10-epoxy-18-hydroxystearate + H2O + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31570", "l": "bisphenol A + H(+) + NADH + O2 <=> 2,2-bis(4-hydroxyphenyl)-1-propanol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5693691", "l": "CES1 trimer.CES2 hydrolyse COCN to BEG (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1861621", "l": "Cross-linking of FCGRIIA with IgG-coated Ag (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9702818", "l": "CALCR binds erenumab (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-69142", "l": "Recruitment of Dna2 endonuclease (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799202", "l": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.20.14", "l": "\"hapalindole-type alkaloid chlorinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31595", "l": "(Z)-2-methylureidoacrylate + H2O = (Z)-2-methylaminoacrylate + carbamate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033956", "l": "beta-apiosyl-beta-glucosidase activity", "d": ["Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.124229784389755", "identifiers": [{"i": "GO:0140678", "l": "molecular function inhibitor activity", "d": ["A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47952", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O = [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)", "d": [], "t": []}, {"i": "EC:3.5.1.119", "l": "\"Pup amidohydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61124", "l": "kaempferol + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + oxidized [NADPH--hemoprotein reductase] + quercetin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983145", "l": "Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855711", "l": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2023973", "l": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19942", "l": "norcoclaurine + S-adenosyl-L-methionine => coclaurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60811", "l": "gibberellin A19 + H(+) + O2 <=> CO2 + gibberellin A20 + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19132", "l": "ATP + thymidine <=> ADP + dTMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1299338", "l": "Activation of TRESK (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8857555", "l": "EGFR phosphorylates GPNMB (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-202703", "l": "CD47 binds SIRP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9027607", "l": "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56972", "l": "(R)-3-hydroxy-2-methylpropanoate + NAD(+) = (R)-2-methyl-3-oxopropanoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3222533", "l": "ERK1/2-activated AP1 complex binds KDM6B promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8944263", "l": "Association of procollagen type II (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6805103", "l": "AURKA phosphorylates TP53 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35944", "l": "brevianamide F + dimethylallyl diphosphate => deoxybrevianamide E + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62884", "l": "O2 + 4 semiviriditoxin = 2 (M)-viriditoxin + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-373145", "l": "fumarate + H2O <=> malate (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0043120", "l": "tumor necrosis factor binding", "d": ["Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64416", "l": "D-xylofuranose + NADP(+) = D-xylono-1,4-lactone + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.424", "l": "\"D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,4-lactone-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6790454", "l": "SUMOylation of XPC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9698929", "l": "pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-110234", "l": "Cleavage of ethenocytosine by TDG glycosylase  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10363", "l": "3,4-dihydrocoumarin + H2O <=> 3-(2-hydroxyphenyl)propanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8852351", "l": "GTSE1 promotes translocation of TP53 to the cytosol (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1169395", "l": "ISGylation of viral protein NS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5678490", "l": "ATG16L1 complex transfers LC3 from ATG3 to PE (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29149", "l": "2 H(+)(out) + H2O + nitrite + ubiquinone-8 => 2 H(+)(in) + nitrate + ubiquinol-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9034042", "l": "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54676", "l": "(2E,6E,10E)-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate", "d": [], "t": []}, {"i": "EC:5.5.1.29", "l": "\"(+)-kolavenyl diphosphate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59158", "l": "AMP + diphosphate + icosanoyl-[(phenol)carboxyphthiodiolenone synthase] => ATP + eicosanoate + holo-[(phenol)carboxyphthiodiolenone synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30586", "l": "2-demethylmenaquinol-8 + H(+) + trimethylamine N-oxide <=> 2-demethylmenaquinone-8 + H2O + trimethylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047140", "l": "glutathione-CoA-glutathione transhydrogenase activity", "d": ["Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170847", "l": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8941234", "l": "SH3PXD2A binds ADAM12,ADAM15,ADAM19 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-203156", "l": "Platelet-derived TREM-1 ligand binds to TREM-1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41144", "l": "1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O => 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56335", "l": "5'-triphosphoadenylyl-(2'->5')-adenosine + H2O <=> AMP + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-159425", "l": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-375140", "l": "CDO binds promyogenic cadherins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2213235", "l": "Trafficking of nonameric complex in the endocytic pathway (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8863471", "l": "LDLR is bound by DAB2 and ARH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814559", "l": "Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41643", "l": "3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8854071", "l": "Proteasome-mediated degradation of PolyUb-FBXL7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37397", "l": "1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA => (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17167", "l": "diphosphate + dTDP-D-galactose => alpha-D-galactose 1-phosphate + dTTP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2028591", "l": "Phosphorylation of STK3 (MST2) and SAV1 by STK3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77291", "l": "(9Z,12Z)-octadecadienoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27308", "l": "1-pyrroline-2-carboxylate + AH2 => A + D-proline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3323079", "l": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19750", "l": "[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose => [(1->3)-alpha-D-glucosyl](n+1) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34328", "l": "4-nitrophenol + H(+) + NADPH + O2 => 1,4-benzoquinone + H2O + NADP(+) + nitrite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43537", "l": "2 D-glyceraldehyde 3-phosphate => 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8847637", "l": "NSF and SNAPs bind the cis-SNARE at the Golgi (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9766687", "l": "SESN1,SESN1 bind SQSTM1 and KEAP1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-194311", "l": "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47503", "l": "cholate + NADP(+) <=> 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37706", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA <=> 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44700", "l": "a 2,3-saturated acyl-CoA + FAD + H(+) = a (2E)-enoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928615", "l": "EFNBs bind SFKs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50216", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = (8S)-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689539", "l": "ADRM1:26S proteaseome binds USP14 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53820", "l": "chenodeoxycholate + NADP(+) = 7-oxolithocholate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102232", "l": "acrolein reductase activity", "d": ["Catalysis of the reaction: acrolein + NADPH + H+ = propanal + NADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031747", "l": "type 2 cysteinyl leukotriene receptor binding", "d": ["Binding to a type 2 cysteinyl leukotriene receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61806", "l": "diphosphate + L-alanyl-5'-AMP => ATP + H(+) + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1678660", "l": "HGSNAT oligomer acetylates Heparan sulfate chain(3) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199299", "l": "AKT phosphorylates FOXO transcription factors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5218818", "l": "Integrin alphaVbeta3 binds p-6Y-VEGFR2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62313", "l": "salicylate + UDP-alpha-D-glucose => H(+) + salicylate 2-O-beta-D-glucoside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8855954", "l": "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75576", "l": "11-O-acetylcyathatriol + A => 11-O-acetylcyathin A3 + AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30755", "l": "ATP + carbamate = ADP + carbamoyl phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37756", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA => 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-193407", "l": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50242", "l": "n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + H2O => [hyaluronan](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64361", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 => (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12756", "l": "glycerol + NADP(+) <=> dihydroxyacetone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38940", "l": "dioscin + 2 H2O => diosgenin 3-O-beta-D-glucoside + 2 L-rhamnopyranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9861725", "l": "PGAM5 dodecamer dephosphorylates p-S336-ME1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-111962", "l": "PDE4A,C,D hydrolyse cAMP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14224", "l": "H2O + monomethyl sulfate <=> H(+) + methanol + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59213", "l": "holo-[(hydroxy)phthioceranic acid synthase] + octadecanoyl-AMP => AMP + H(+) + octadecanoyl-[(hydroxy)phthioceranic acid synthase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-216076", "l": "VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5690827", "l": "TNFAIP3 (A20) ubiquitinates RIPK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45506", "l": "(2R,3E)-phycoerythrobilin + apo-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit] => phycoerythrobilin-L-cysteinyl(84)-[C-phycoerythrin alpha-subunit]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52843", "l": "UDP-alpha-D-glucose + vanillate <=> 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63370", "l": "ADP + H(+) + phosphate + spermine(in) => ATP + H2O + spermine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-211207", "l": "Cleaved fragments of DFF45 dissociate from  DFF40 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22875", "l": "2-oxoglutarate + L-prolyl-[collagen] + O2 <=> CO2 + succinate + trans-3-hydroxy-L-prolyl-[collagen]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40616", "l": "H2O + tridecanoylglycerol => 2,3-didecanoyl-sn-glycerol + decanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389684", "l": "glyoxylate + alanine => glycine + pyruvate [peroxisome] (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14484", "l": "2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O <=> 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72263", "l": "chloride(out) + oxalate(in) = chloride(in) + oxalate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1234183", "l": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha  (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018767", "l": "2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-170850", "l": "Phosphorylated SMAD2/3 dissociates from TGFBR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46760", "l": "2,4-dinitrotoluene + NADH + O2 = 4-methyl-5-nitrocatechol + NAD(+) + nitrite", "d": [], "t": []}, {"i": "EC:1.14.12.24", "l": "\"2,4-dinitrotoluene dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-561054", "l": "OCT2 mediates tubular secretion of organic cations in the kidney (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8954262", "l": "TPST1,2 transfer SO4(2-) from PAPS to PODXL2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17689", "l": "3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate + H(+)", "d": [], "t": []}, {"i": "EC:2.8.2.34", "l": "\"glycochenodeoxycholate sulfotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483165", "l": "PA is converted to CDP-DAG by CDS2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8856189", "l": "TNFSF8 binds TNFRSF8 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8981606", "l": "Myoglobin binds oxygen (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8937169", "l": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48612", "l": "[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]", "d": [], "t": []}, {"i": "EC:2.8.1.11", "l": "\"molybdopterin synthase sulfurtransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1483219", "l": "PC is exchanged with PI by PITPNB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2022403", "l": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10) (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75864", "l": "all-trans-13,14-dihydroretinoate + O2 + reduced [NADPH--hemoprotein reductase] => all-trans-4-hydroxy-13,14-dihydroretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-517444", "l": "TAT aminates HPP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18039", "l": "N-carbamoylputrescine + NH4(+) => agmatine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37593", "l": "1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109538", "l": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44374", "l": "Cr(3+) + 2 H(+) + 2 NAD(+) + superoxide => Cr(6+) + 2 NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1482691", "l": "2-acyl LPS is acylated to PS by LPSAT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814096", "l": "ARL1:GTP binds SCOC (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102865", "l": "delta6-acyl-lipid desaturase activity", "d": ["Catalysis of the reaction: a gamma-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H+ = a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8851827", "l": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8871366", "l": "p-Y389,400-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67048", "l": "AH2 + chermesin D + O2 = A + asnovolin I + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5223317", "l": "ABCB9 transports peptides from cytosol to lysosomal lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46753", "l": "7alpha-hydroxycholest-4-en-3-one + O2 + reduced [NADPH--hemoprotein reductase] => 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41309", "l": "(9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) => 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433114", "l": "NaS1 co-transports sulphate and a sodium ion (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-213175", "l": "CYP3A4,5 oxidise AFB1 to AFXBO (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15628", "l": "Co-precorrin-6B + NAD(+) <=> Co-precorrin-6A + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9647991", "l": "Palmostatin B binds RAS depalmitoylases (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047417", "l": "N-carbamoyl-D-amino acid hydrolase activity", "d": ["Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043908", "l": "Ser(Gly)-tRNA(Ala) hydrolase activity", "d": ["Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25639", "l": "2 H(+) + NADH + sulfoacetate => H2O + NAD(+) + sulfoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-198621", "l": "AKT phosphorylates caspase-9 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-5652151", "l": "REV1 recruits POLZ to (AP:Cyt)-DNA Template (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29366", "l": "dCMP + H2O <=> 2'-deoxycytidine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44002", "l": "2-hydroxy-3-methylhexadecanoyl-CoA + CO2 + succinate => 2-oxoglutarate + 3-methylhexadecanoyl-CoA + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-73591", "l": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24380", "l": "(6R)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)", "d": [], "t": []}, {"i": "EC:2.1.2.9", "l": "\"methionyl-tRNA formyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-893596", "l": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389550", "l": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5693925", "l": "FUT3 transfers L-fucose to Gal1,3GlcNAc (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19704", "l": "a flavonol 3-O-glycoside + UDP-alpha-D-xylose <=> a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33861", "l": "H2O + versicolorin B => (2S-3S)-versiconal hemiacetal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810894", "l": "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692755", "l": "CDK1 phosphorylates MAPK6 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53129", "l": "delta-carotene => epsilon-carotene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0036312", "l": "phosphatidylinositol 3-kinase regulatory subunit binding", "d": ["Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47254", "l": "6beta-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => O2 + progesterone + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-437118", "l": "GPVI stimulates PI3K beta, gamma (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050384", "l": "urate-ribonucleotide phosphorylase activity", "d": ["Catalysis of the reaction: 3-(beta-D-ribofuranosyl)uric acid + phosphate = alpha-D-ribose 1-phosphate + H+ + urate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36534", "l": "(13Z)-docosenoyl-CoA + H(+) + malonyl-CoA <=> (15Z)-3-oxotetracosenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35729", "l": "1-dodecanoyl-sn-glycerol 3-phosphate + CoA => dodecanoyl-CoA + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8941895", "l": "Formation of CDK4/6:CCND complexes (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41303", "l": "H2O + N-dodecanoyl-(4R)-hydroxysphinganine = (4R)-hydroxysphinganine + dodecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163751", "l": "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   <=> xylulose 5-phosphate + D-erythrose 4-phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5661123", "l": "KDM1A, KDM1B demethylate Me2K5-histone H3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5672951", "l": "Inactive RAFs bind YWHAB (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75883", "l": "DHRS7B reduces GO3P to HXDG3P (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043273", "l": "CTPase activity", "d": ["Catalysis of the reaction: CTP + H2O = CDP + H+ + phosphate. May or may not be coupled to another reaction."], "t": []}, {"i": "RHEA:29387", "l": "CTP + H2O = CDP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44740", "l": "27-O-demethylrifamycin SV + S-adenosyl-L-methionine = H(+) + rifamycin SV + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.315", "l": "\"27-O-demethylrifamycin SV methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9838289", "l": "CLPXP degrades mitochondrial matrix proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50792", "l": "18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced [adrenodoxin] = aldosterone + 2 H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9645481", "l": "TIFA oligomerization (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950456", "l": "IL12B dimerizes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.2.1.93", "l": "\"ATP-dependent NAD(P)H-hydrate dehydratase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56106", "l": "4,4'-diaponeurosporenal + 2 A + 3 H2O => 2 AH2 + all-trans-4,4'-diaponeurosporene + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37623", "l": "(9Z)-octadecenoyl-CoA + a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-75822", "l": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2752067", "l": "BESTs transport cytosolic HCO3- to extracellular region (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444208", "l": "MLNR (GPR38) is a receptor for motilin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59762", "l": "apigenin 7-O-beta-D-glucoside + H(+) + UDP => apigenin + UDP-alpha-D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5607731", "l": "26S proteasome processes p-7S-p100:RELB to form p52:RELB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3371590", "l": "HSP70 binds to HSP40:nascent protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18099", "l": "H(+) + xanthine-8-carboxylate => pteridine-2,4,6,7-tetrol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21340", "l": "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 vanillin", "d": [], "t": []}, {"i": "EC:1.13.11.43", "l": "\"lignostilbene alphabeta-dioxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26420", "l": "(2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal => (3R)-3-hydroxy-8'-apo-beta-carotenal + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6798611", "l": "TP53 stimulates and ZNF420 inhibits TP53AIP1 expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57613", "l": "20 H(+) + holo-[compactin nonaketide synthase] + 9 malonyl-CoA + 11 NADPH => 9 CO2 + 9 CoA + dihydro-ML-236C-[compactin nonaketide synthase] + 6 H2O + 11 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43836", "l": "cholesterol + H(+) + NADPH + O2 = 26-hydroxycholesterol + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1497796", "l": "BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24616", "l": "17beta-estradiol + NADP(+) = estrone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-140806", "l": "SERPINC1 binds SERPINC1 activators (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13675", "l": "[protein-PII]-uridylyl-L-tyrosine + diphosphate => [protein-PII]-L-tyrosine + UTP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40046", "l": "ATP + citrate + L-glutamate <=> ADP + beta-citrylglutamate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62537", "l": "digoxigenin + 2 Fe(II)-[cytochrome c] + 3 H(+) => dihydrodigoxigenin + 2 Fe(III)-[cytochrome c]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43265", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + eicosanoyl-CoA => 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-265427", "l": "Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34202", "l": "2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + H(+) + O2 <=> bracteatin 6-O-beta-glucoside + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-982810", "l": "JAK2 phosphorylation (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809393", "l": "Keratin filaments bind cell-cell adhesion complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983285", "l": "RAD51B binds RAD51C (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23659", "l": "2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate <=> 3-carboxy-cis,cis-muconate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45537", "l": "H2O + N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-octadecanoyl ethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51702", "l": "4'-O-methylxanthohumol + H(+) + S-adenosyl-L-homocysteine => S-adenosyl-L-methionine + xanthogalenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56984", "l": "(2E,6E)-farnesyl diphosphate + H2O = (6E)-nerolidol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2028679", "l": "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-380508", "l": "Translocation of NuMA to the centrosomes (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76719", "l": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 3-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5682709", "l": "LGI4 binds ADAM22,23,11 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15017", "l": "a phosphate monoester + H2O = an alcohol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030758", "l": "3,7-dimethylquercitin 4'-O-methyltransferase activity", "d": ["Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23234", "l": "4 Fe(II)-[cytochrome c] + 4 H(+) + N2 => 4 Fe(III)-[cytochrome c] + hydrazine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8878664", "l": "SLC4A4 cotransports Na+ with 3HCO3- (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30312", "l": "7-methylxanthine + H(+) + NADH + O2 => formaldehyde + H2O + NAD(+) + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-428262", "l": "ACER3 hydrolyzes phytoceramide (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809140", "l": "IL35 binds IL-12RB2:IL6ST receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5663002", "l": "MT3 binds copper (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:79107", "l": "glycocholate + L-histidine = glycine + L-histidocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50962", "l": "H(+) + N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine => cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2046089", "l": "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8948228", "l": "COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9021072", "l": "ZDHHC7, ZDHHC21 palmitoylate ESR1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76266", "l": "ergothioneine(in) <=> ergothioneine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71147", "l": "3-hydroxyhispidin + O2 = 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37604", "l": "(11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate => 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9840564", "l": "OMA1 hydrolyzes YME1L1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8847638", "l": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19048", "l": "acetyl-CoA + H2O + pyruvate <=> (3R)-citramalate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-977363", "l": "Factor H binds to C3bBb (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52338", "l": "a long-chain fatty acyl-AMP + diphosphate => a long-chain fatty acid + ATP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9677917", "l": "MAOA inhibitors bind MAOA:FAD (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8940998", "l": "IL36RN, IL1F10 bind IL1RL2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5159245", "l": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9012689", "l": "IL37(1-?) and IL37 (?-) dissocates from IL37(1-?):IL37(?-218):CASP1(120-197):CASP1(317-404) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047510", "l": "(S)-2-methylmalate dehydratase activity", "d": ["Catalysis of the reaction: S-citramalate = H2O + mesaconate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1011598", "l": "DOCKs bind to RhoGEFs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-448741", "l": "IL22RA2 binds IL22 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-429157", "l": "ABCC4 accumulation of dense granule contents (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8944215", "l": "Association of procollagen type XX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70773", "l": "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA] (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098614", "l": "hydrogen selenide methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + hydrogen selenide => S-adenosyl-L-homocysteine + methaneselenol."], "t": []}, {"i": "REACT:R-HSA-2408536", "l": "H2Se is methylated to MeSeH by H2Se methyltransferase (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1112703", "l": "PTPN11 is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37822", "l": "1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA <=> 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9734475", "l": "PPARA binds fibrates (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8848077", "l": "PTK6 phosphorylates STAP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65968", "l": "17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043731", "l": "6-hydroxynicotinate 3-monooxygenase activity", "d": ["Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9614562", "l": "14-3-3 proteins bind AKT-phosphorylated FOXO3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48654", "l": "20-hydroxy-lipoxin B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => lipoxin B4 + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005352", "l": "alpha-glucoside:proton symporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36882", "l": "(8Z,11Z,14Z)-eicosatrienoyl-CoA + AH2 + O2 <=> (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59064", "l": "demethylluteothin + S-adenosyl-L-methionine = luteothin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-111437", "l": "Cleavage of the 3'-end of the Histone Pre-mRNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56779", "l": "(+)-pinoresinol + O2 + reduced [NADPH--hemoprotein reductase] <=> (+)-piperitol + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-975389", "l": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-205112", "l": "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43006", "l": "2-aminoprop-2-enoate + CO2 + NH4(+) => H(+) + O-carbamoyl-L-serine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74582", "l": "H2O + N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] <=> N-acetyl-L-cysteine + N-terminal L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-70241", "l": "PCK1 phosphorylates OA to yield PEP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050199", "l": "piperidine N-piperoyltransferase activity", "d": ["Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = N-[(E,E)-piperoyl]piperidine + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MTU-937192", "l": "Cysteine from cystathionine and vice versa (Mycobacterium tuberculosis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050288", "l": "sorbose dehydrogenase activity", "d": ["Catalysis of the reaction: L-sorbose + A = 5-dehydro-D-fructose + AH(2)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8983834", "l": "JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61653", "l": "2,3-dihydroxybenzoate + ATP + holo-[ACP] => 2,3-dihydroxybenzoyl-[ACP] + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-446083", "l": "CD151 interacts with BP180 and the integrin alpha 6 subunit (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-914017", "l": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888572", "l": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-391905", "l": "Oxoeicosanoid receptor can bind oxoeicosanoid (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201810", "l": "The ligand trap binds the ligand BMP2, blocking BMP signalling (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12922", "l": "glycine + H(+) + succinyl-CoA => 5-aminolevulinate + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32308", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => H2O + leukotriene A4", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31245", "l": "(4S)-4-hydroxy-L-glutamate + 2 H(+) + NADH => H2O + L-4-hydroxyglutamate semialdehyde + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14494", "l": "H2O + N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] => ADP-D-ribose + L-arginyl-[dinitrogen reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-200718", "l": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8853737", "l": "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30039", "l": "3,4-dihydroxybenzoate + 2 H(+) + NADPH + O2 = benzene-1,2,4-triol + CO2 + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6811426", "l": "Retrograde COPI vesicles bind kinesin and microtubules (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11831", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O <=> a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1482656", "l": "PA is hydrolysed to 1-acyl LPA by PLA2[1] (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26374", "l": "[thioredoxin]-disulfide + prostamide F2alpha => [thioredoxin]-dithiol + prostamide H2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46111", "l": "(2E,6E,10E)-geranylgeraniol + H(+) + 2 NADPH + 2 O2 <=> (2E,6E,10E)-geranylgeranate + 3 H2O + 2 NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57668", "l": "alpha-nootkatol + O2 + reduced [NADPH--hemoprotein reductase] = (+)-nootkatone + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67204", "l": "H2O + N-acetyltryptamine = acetate + tryptamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9673761", "l": "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-2023971", "l": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6814885", "l": "CBCAP complex binds 7-methylguanosine cap of snRNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6801762", "l": "REG3A oligomerize to form a pore complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57588", "l": "(2S)-naringenin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-2-hydroxynaringenin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27293", "l": "A + formate + H(+) <=> AH2 + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-69227", "l": "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6791016", "l": "SFTPB binds itself (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61549", "l": "ent-kaur-16-en-19-oate + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] => ent-7alpha-hydroxykaur-16-en-19-oate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.1.50", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2168888", "l": "Alpha1-Microglobulin binds heme (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76886", "l": "3-aminobutan-1-ol + H2O + NAD(+) <=> 4-hydroxybutan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-6807206", "l": "USP13 and OTUD3 deubiquitinate PTEN (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6799466", "l": "TP53I3 dimerizes (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5578965", "l": "TNRC6A binds AGO2:miRNA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56341", "l": "ent-isokauren-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] => ent-isokaurene-2beta,3beta-diol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9028255", "l": "PTGS2 dimer oxidises EPA to PGH3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6797913", "l": "SARDH:FAD oxidatively demethylates SARC to Gly (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32586", "l": "dihydrocarvone + H(+) + NADPH + O2 <=> 6-isopropenyl-3-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29121", "l": "a ubiquinone + H2O + nitrite => a ubiquinol + nitrate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58347", "l": "beta-D-glucosyl-(1->3)-O-lithocholate + H2O <=> D-glucose + lithocholate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10899", "l": "2 H2O + limonin <=> 2 H(+) + limonoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-390393", "l": "Peroxisomal uptake of very long-chain fatty acyl CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5684071", "l": "RNF4 ubiquitinates MDC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835151", "l": "Packaging of RdRP complex with replicated hRSV A nucleocapsid (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57151", "l": "1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine <=> 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-189384", "l": "BLVRA:Zn2+, BLVRB reduce BV to BIL (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77170", "l": "AH2 + hercynyl-SeGlcNAc selenoxide <=> 2-acetamidoglucal + A + H2O + selenoneine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55213", "l": "(2R)-hydroxyhexadecanoyl-CoA => formyl-CoA + pentadecanal", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.45", "l": "\"melamine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-205136", "l": "GTP-bound RAC contributes to JNK activation (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70394", "l": "3-oxosphinganine + eicosanoyl-CoA <=> CoA + H(+) + N-eicosanoyl-3-oxosphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9749986", "l": "CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166387", "l": "The FA anion diffuses away laterally from UCP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6798474", "l": "S100A8:S100A9 binds Zn2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8871227", "l": "RET binds GFRA4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2395517", "l": "NADPH transfers electrons to FDXR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70228", "l": "(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA => (E)-2-benzylidenesuccinyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8981892", "l": "Active G alpha (z) binds RGS proteins (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-164840", "l": "ADP and Pi bind to ATPase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-420173", "l": "CRHR1,CRHR2-1 binds CRH,UCN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4088024", "l": "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61804", "l": "ATP + H(+) + L-alanine = diphosphate + L-alanyl-5'-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51186", "l": "H(+) + octadecanoate + sn-glycero-3-phospho-L-serine => 1-octadecanoyl-sn-glycero-3-phosphoserine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49490", "l": "2-oxoglutarate + GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+) => GDP-4-dehydro-alpha-D-rhamnose + L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13853", "l": "4-methylene-L-glutamate + ATP + NH4(+) = 4-methylene-L-glutamine + AMP + diphosphate + H(+)", "d": [], "t": []}, {"i": "EC:6.3.1.7", "l": "\"4-methyleneglutamate--ammonia ligase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.13.12.11", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6785928", "l": "CHAC1,2 cleaves GSH to OPRO and CysGly (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.392", "l": "\"3-O-beta-D-glucopyranosyl-beta-D-glucuronide phosphorylase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64837", "l": "2-phenylethanol + acetyl-CoA => CoA + phenethyl acetate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0015420", "l": "ABC-type vitamin B12 transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18222", "l": "1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O => a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38477", "l": "H(+) + N(alpha)-methyl-L-histidine + S-adenosyl-L-homocysteine => L-histidine + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37947", "l": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.99.n2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9632033", "l": "CHSY1 transfers GalNAc to chondroitin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1369028", "l": "ABCAs mediate lipid efflux (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9823906", "l": "TBK1 is phosphorylated within the activated TLR4 complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-111879", "l": "PIP2 hydrolysis (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47121", "l": "docosanoate + glycine => H2O + N-docosanoylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-194187", "l": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-888577", "l": "Synthesis of GABA by GAD2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73018", "l": "D-leucine(in) <=> D-leucine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-375131", "l": "Basigin binds CD98 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68470", "l": "(E)-gamma-bisabolene + diphosphate => (2Z,6Z)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-425661", "l": "SLC8A1,2,3 exchange 3Na+ for Ca2+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60615", "l": "1-octanoyl-sn-glycero-3-phosphocholine <=> 1-octanoyl-sn-glycero-2,3-cyclic phosphate + choline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66770", "l": "ADP + coproporphyrin I(out) + H(+) + phosphate => ATP + coproporphyrin I(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26361", "l": "L-tyrosine + NADPH + S-adenosyl-L-methionine = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)", "d": [], "t": []}, {"i": "EC:4.1.99.19", "l": "\"2-iminoacetate synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2404193", "l": "IGF1R phosphorylates SHC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36866", "l": "(9Z)-octadecenoyl-CoA + AH2 + O2 <=> (9Z,12Z)-octadecadienoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9708261", "l": "PDE4A hydrolyses cAMP to AMP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66896", "l": "4 O2 + ophiobolin F + 4 reduced [NADPH--hemoprotein reductase] = 4 H(+) + 6 H2O + ophiobolin C + 4 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65248", "l": "AH2 + 5 H(+) + 5 malonyl-CoA = 6-hydroxymellein + A + 5 CO2 + 5 CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67605", "l": "H2O + N(6)-methyl-dATP => diphosphate + H(+) + N(6)-methyl-dAMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-190427", "l": "Autocatalytic phosphorylation of FGFR1b (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15256", "l": "cis-aconitate + H(+) <=> CO2 + itaconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55488", "l": "ent-cassa-12,15-dien-2beta-ol + O2 + reduced [NADPH--hemoprotein reductase] = ent-cassa-12,15-dien-2-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60009", "l": "a tRNA precursor + 2 CTP => a tRNA with a 3' CC end + 2 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51740", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H(+) + lipid A = a 1,2-diacyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44223", "l": "15-hydroxypentadecanoate + ATP + CoA <=> 15-hydroxypentadecanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77995", "l": "9-hydroxy-octadecanoate + a 1,2-diacyl-sn-glycerol = 9-(acyloxy)-octadecanoate + a 2-acylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5696655", "l": "PARP1 or PARP2 PARylates DDB2 and autoPARylates (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8932033", "l": "KCTD6 gene expression is stimulated by RUNX1 and ESR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-70501", "l": "PC carboxylates PYR to OA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015462", "l": "ABC-type protein transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8985343", "l": "RUNX2 binds SOX9 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9737046", "l": "L-Glutamate binds GRM4 (mGluR4) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8851859", "l": "Activated MET binds RANBP9 and SOS1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8874685", "l": "CBL binds MET (Canis familiaris)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645428", "l": "ALPK1 binds ADP-heptose (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36052", "l": "beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O => 2 beta-L-arabinofuranose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008191", "l": "metalloendopeptidase inhibitor activity", "d": ["Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0030413", "l": "competence pheromone activity", "d": ["A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-209738", "l": "VD3 binds GC (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39593", "l": "(2E,10Z,13Z,16Z,19Z,22Z,25Z)-octacosaheptaenoyl-CoA + H2O => (3R)-hydroxy-(10Z,13Z,16Z,19Z,22Z,25Z)-octacosahexaenoyl-CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64903", "l": "H2O + UTP <=> H(+) + phosphate + UDP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34476", "l": "2 (2E,6E,10E)-geranylgeranyl diphosphate => 15-cis-phytoene + 2 diphosphate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13720", "l": "2-C-methyl-D-erythritol 4-phosphate + NADP(+) <=> 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-202723", "l": "Integrin alpha5beta1 binds FN1 dimer (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24671", "l": "H2O + hypoxanthine + NAD(+) => H(+) + NADH + xanthine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018537", "l": "coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity", "d": ["Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme F420 + H+ = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70639", "l": "H2O + N(6)-hexanoyl-L-lysyl-[protein] + NAD(+) = 2''-O-hexanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8876616", "l": "DENND6A,B exchange GTP for GDP on RAB14 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-425678", "l": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-5649800", "l": "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0030556", "l": "rRNA modification guide activity", "d": ["Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55165", "l": "a jasmonyl-L-isoleucinate + H(+) + NADPH + O2 => H2O + L-isoleucine-12-hydroxyjasmonate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046564", "l": "oxalate decarboxylase activity", "d": ["Catalysis of the reaction: H+ + oxalate = CO2 + formate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9021596", "l": "Membrane estrogen receptors bind SRC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2744361", "l": "BESTs transport cytosolic Cl- to extracellular region (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0051373", "l": "FATZ binding", "d": ["Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-446391", "l": "Formation of the PINCH-ILK-parvin complex (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047243", "l": "flavanone 7-O-beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1655879", "l": "Thiosulfate can transfer its sulfur atom to glutathione (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-508369", "l": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-69754", "l": "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692779", "l": "p-T182 MAPKAPK5 phosphorylates FOXO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33940", "l": "H(+) + L-arginine + NADH + O2 => H2O + N(omega)-hydroxy-L-arginine + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-194121", "l": "SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66167", "l": "butanoyl-CoA + serotonin <=> CoA + H(+) + N-butanoylserotonin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23225", "l": "trans-zeatin + UDP-alpha-D-glucose => H(+) + O-beta-D-glucosyl-trans-zeatin + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63951", "l": "H2O + sphinga-4E,14Z-dienine-1-phosphate <=> phosphate + sphinga-4E,14Z-dienine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23147", "l": "H2O + N-acetyl-alpha-D-glucosamine + NAD(+) <=> 2 H(+) + N-acetyl-D-glucosaminate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8983996", "l": "STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16038", "l": "phosphate + thymidine => 2-deoxy-alpha-D-ribose 1-phosphate + thymine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-381545", "l": "Formation of the IGF:IGFBP5:ALS complex (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20769", "l": "3-phosphonopyruvate + H(+) => CO2 + phosphonoacetaldehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54956", "l": "ATP + CoA + OPC-6 = AMP + diphosphate + OPC-6-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6804485", "l": "PIAS1 SUMOylates L3MBTL2 with SUMO2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33347", "l": "2-iminoacetate + H2O = glyoxylate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31537", "l": "CO2 + guanidine + L-glutamate 5-semialdehyde + succinate => 2-oxoglutarate + L-arginine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9759549", "l": "Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61236", "l": "H2O + L-methionine + O2 = 4-methylsulfanyl-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "69.900936324171454", "identifiers": [{"i": "GO:0005126", "l": "cytokine receptor binding", "d": ["Binding to a cytokine receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6809006", "l": "Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-204169", "l": "PDP1,2 dephosphorylate p-lipo-PDH (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-373732", "l": "Nephrin trans-homophilic interaction (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9629679", "l": "PDE3A inhibitors bind PDE3A (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1602454", "l": "proMMP9 binds TIMP1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-71660", "l": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65890", "l": "4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate => 2-oxoglutarate + 3-hydroxy-L-kynurenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39493", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + NADP(+) => (2E,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1614336", "l": "SUMF2 binds SUMF1, inhibiting SUMF1-mediated activation of arylsulfatases (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2730959", "l": "CLCN7:OSTM1 exchanges Cl- for H+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33592", "l": "sphinganine + tetracosanoyl-CoA => CoA + H(+) + N-tetracosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "89.386748736829375", "identifiers": [{"i": "GO:0016453", "l": "C-acetyltransferase activity", "d": ["Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31573", "l": "CO2 + H2O + NADP(+) + naphthalene-1,2-diol => 1-hydroxy-2-naphthoate + 2 H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-73571", "l": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392295", "l": "Gbeta:gamma recruits PI3K gamma (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2029471", "l": "Hydrolysis of PC to PA by PLD (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-2076220", "l": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38153", "l": "CO2 + H(+) + hydrogen sulfide => carbonyl sulfide + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-451310", "l": "Activation of Edited Kainate receptors (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.427", "l": "\"D-arabinose 1-dehydrogenase (NADP(+))\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "78.265986832370587", "identifiers": [{"i": "GO:0016895", "l": "DNA exonuclease activity, producing 5'-phosphomonoesters", "d": ["Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74022", "l": "glycine(out) + L-alanine(in) <=> glycine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209960", "l": "Diiodinated tyrosine can be deiodinated (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55471", "l": "11-hydroxyferruginol + O2 + reduced [NADPH--hemoprotein reductase] <=> 11,20-dihydroxyferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102771", "l": "dihydroceramide fatty acyl 2-hydroxylase activity", "d": ["Catalysis of the reaction: an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 = an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8953461", "l": "SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2179402", "l": "Active MMP3 can cleave pro-HBEGF to form active HBEGF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008760", "l": "UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity", "d": ["Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-193746", "l": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75682", "l": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate <=> (12R,13R)-epoxy-(11S)-hydroxy-(9Z)-octadecenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-449855", "l": "IL10 dimerizes (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77212", "l": "3'-phosphoadenylyl sulfate + taurodeoxycholate => 3alpha-sulfotaurodeoxycholate + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0018548", "l": "pentaerythritol trinitrate reductase activity", "d": ["Catalysis of the reaction: pentaerythritol trinitrate + NADPH = NADP+ + nitrate + pentaerythritol dinitrate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005019", "l": "platelet-derived growth factor beta-receptor activity", "d": ["Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25955", "l": "1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde <=> 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950448", "l": "STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46775", "l": "1-octadecanoyl 2-acyl-glycerolipid + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 H2O + 2 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-69562", "l": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-418874", "l": "Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43904", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinol = 2-hexadecanoyl-sn-glycero-3-phosphocholine + all-trans-retinyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1226095", "l": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35964", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tryprostatin A => fumitremorgin C + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9684277", "l": "mRNA1 is translated to pp1ab (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27902", "l": "caffeine + H2O + ubiquinone-0 = 1,3,7-trimethylurate + ubiquinol-0", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39543", "l": "3-oxo-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + H(+) + NADPH = (3R)-hydroxy-(21Z,24Z,27Z,30Z,33Z)-hexatriacontapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9629591", "l": "JMJD7 dimer hydroxlates a lysine residue of DRG1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68351", "l": "ATP + GTP <=> diphosphate + pppA(2'-5')pG", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120243", "l": "2-iminopropanoate deaminase activity", "d": ["Catalysis of the reaction: 2-iminopropanoate + H2O = NH4(+) + pyruvate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8955844", "l": "RBKS phosphorylates ribose to R5P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5324632", "l": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004733", "l": "pyridoxamine phosphate oxidase activity", "d": ["Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH4+ + hydrogen peroxide. This activity can also oxidize pyridoxine 5'-phosphate to pyridoxal 5'-phosphate + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73387", "l": "H(+)(in) + malonate(out) + phosphate(in) = H(+)(out) + malonate(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008961", "l": "phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity", "d": ["Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8951648", "l": "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-3697860", "l": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9025995", "l": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2301205", "l": "SETD8 monomethylates histone H4 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0090600", "l": "alpha-1,3-glucosidase activity", "d": ["Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->3)-linked alpha-D-glucose residues with release of alpha-D-glucose."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50543", "l": "prostaglandin A2 <=> prostaglandin C2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035991", "l": "nitric oxide sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74178", "l": "a secondary alkyl amine + H2O + NAD(+) <=> a ketone + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43171", "l": "adenosine(34) in tRNA + H(+) + H2O <=> inosine(34) in tRNA + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.5.1.n2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17183", "l": "a long-chain fatty acid + FMN + 2 H(+) + H2O + hnu => a long-chain fatty aldehyde + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.3.33", "l": "\"polynucleotide 5'-phosphatase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5671772", "l": "p-T38-PPP1R14A binds MLCP (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-373750", "l": "SEMA4D interacts with Plexin-B1:ErbB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42291", "l": "6-carboxyhexanoyl-[ACP] + H(+) + L-alanine <=> (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57758", "l": "C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 CoA + 2 H2O + 5 NADP(+) => 2 (S)-methylmalonyl-CoA + 17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 10 H(+) + 3 malonyl-CoA + 5 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.5.2", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19524", "l": "acetyl-CoA + phosphate <=> acetyl phosphate + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9840334", "l": "PSAP gets cleaved (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2465890", "l": "DDR2 binds collagen type I, II, III, V, X fibrils (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8940100", "l": "CDK1 phosphorylates VCPIP1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8874685", "l": "CBL binds MET (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-2127257", "l": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28610", "l": "H2O + XTP = diphosphate + H(+) + XMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55951", "l": "A + D-alanine + H2O <=> AH2 + NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51998", "l": "a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => an (E)-omega-(methylsulfanyl)-alkanal oxime + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008730", "l": "L(+)-tartrate dehydratase activity", "d": ["Catalysis of the reaction: L-tartrate = H2O + oxaloacetate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55224", "l": "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28359", "l": "FAD + H(+) + tetradecanoyl-CoA => (2E)-tetradecenoyl-CoA + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65836", "l": "AH2 + ATP + 2 Co(II)-[trimethylamine-specific corrinoid protein] + H2O = A + ADP + 2 Co(I)-[trimethylamine-specific corrinoid protein] + 3 H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8938887", "l": "PML binds RUNX1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6783530", "l": "gp130:JAKs bind CNTFR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11290", "l": "H2O2 + macarpine => dihydromacarpine + H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36896", "l": "(9Z,12Z,15Z)-octadecatrienoyl-CoA + AH2 + O2 => (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + A + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-374922", "l": "Noradrenalin synaptic vesicle docking and priming (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-2046095", "l": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76811", "l": "(S)-methioninol + H2O + NAD(+) = 1-hydroxy-4-(methythio)butan-2-one + H(+) + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-1878002", "l": "XYLTs transfer Xyl to core protein (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72453", "l": "a dicarboxylate(out) + dehydroepiandrosterone 3-sulfate(in) => a dicarboxylate(in) + dehydroepiandrosterone 3-sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990411", "l": "hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)", "d": ["Catalysis of the reaction: hercynylcysteine sulfoxide + 2H+ = ergothioneine + pyruvate + ammonium."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1678650", "l": "IDS hydrolyses Heparan sulfate chain(5) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44679", "l": "a triacylglycerol + all-trans-retinol <=> a diacylglycerol + an all-trans-retinyl ester", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73507", "l": "7,8-dihydroxyflavone + S-adenosyl-L-methionine = 7-hydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-751027", "l": "Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043879", "l": "glycolate transmembrane transporter activity", "d": ["Enables the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA)."], "t": []}, {"i": "RHEA:29447", "l": "glycolate(in) = glycolate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78715", "l": "3-dehydro-alpha-D-glucosyl beta-D-fructofuranoside + H2O = 3-dehydro-D-glucose + D-fructose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-202375", "l": "Recruitment of ITK to SLP-76 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8853710", "l": "MANBA hydrolyses GlcNAc:Man (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34071", "l": "trans,octa-cis-decaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-1-diphospho-trans,octa-cis-decaprenol + UMP", "d": [], "t": []}, {"i": "EC:2.7.8.35", "l": "\"UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102741", "l": "paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity", "d": ["Catalysis of the reaction: 1,7-dimethylxanthine + S-adenosyl-L-methionine = H+ + caffeine + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8875490", "l": "EPS15 and HGS bind ubiquitinated MET (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10216", "l": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]", "d": [], "t": []}, {"i": "EC:2.7.11.23", "l": "\"[RNA-polymerase]-subunit kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005476", "l": "carnitine:acyl carnitine antiporter activity", "d": ["Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59707", "l": "D-cellohexaono-1,5-lactone + H2O <=> D-cellohexaonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-352354", "l": "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9621399", "l": "SCD5 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54828", "l": "dimethylamine + H(+) + NADPH + O2 = formaldehyde + H2O + methylamine + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.238", "l": "\"dimethylamine monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-193535", "l": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836322", "l": "p-PKR dimer phosphorylates MKK6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-4641345", "l": "SUMOylation of TOP2B with SUMO1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-427514", "l": "eNoSC deacetylates histone H3 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0051393", "l": "alpha-actinin binding", "d": ["Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9825754", "l": "HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6781814", "l": "USP19 deubiquitinates RNF123 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5638014", "l": "RAB11A:GTP-containing Golgi vesicles recruit RAB3IP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0005522", "l": "profilin binding", "d": ["Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48377", "l": "a neolactoside nLc4Cer + GDP-beta-L-fucose => a neolactoside III(3)-alpha-Fuc-nLc4Cer + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3697882", "l": "PRDX5 reduces peroxynitrite to nitrite using TXN (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54961", "l": "ATP + CoA + dinor-OPDA => AMP + dinor-OPDA-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21327", "l": "2 H(+) + reduced [rubredoxin] + superoxide <=> H2O2 + oxidized [rubredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76372", "l": "n H(+)(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) => n H(+)(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-751029", "l": "Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5578883", "l": "Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27633", "l": "ethylene glycol + NAD(+) <=> glycolaldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30908", "l": "(S)-3-methyl-2-oxopentanoate + CoA + NAD(+) => 2-methylbutanoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73270", "l": "H(+)(out) + L-methionine(in) <=> H(+)(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11314", "l": "chloride + H(+) + hydroxyatrazine => atrazine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54425", "l": "L-aspartyl-[protein] + NAD(+) => 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53526", "l": "1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+) => 1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine + 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9634584", "l": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-202132", "l": "depalmitoylated eNOS translocates from plasma membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50667", "l": "a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose <=> an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51132", "l": "a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a purine nucleobase", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9024983", "l": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1675824", "l": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67069", "l": "AH2 + chermesin D methyl ester => A + asnovolin J", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14285", "l": "sn-glycerol 3-phosphate + UDP-alpha-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.137", "l": "\"sn-glycerol-3-phosphate 2-alpha-galactosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2197690", "l": "Detachment of WASP/WAVE (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9645535", "l": "ALPK1 phosphorylates TIFA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59413", "l": "2-oxosuccinamate + H2O => NH4(+) + oxaloacetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62321", "l": "(+)-premalbrancheamide + chloride + FAD + 2 H(+) => (+)-isomalbrancheamide B + FADH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9014294", "l": "RAC2 binds effectors at the plasma membrane (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675456", "l": "FLIP(L) and procaspase-8 form heterodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-110316", "l": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46168", "l": "ATP + CoA + pentanoate = AMP + diphosphate + pentanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34708", "l": "AH2 + alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine => 5'-deoxyadenosine + A + alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H(+) + L-methionine + methane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-873927", "l": "Release of STAT1 dimer from active receptor unit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8876485", "l": "CHOL translocates from lysosome membrane to ER membrane (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-210283", "l": "Interaction of PECAM-1 and PLC gamma1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5689111", "l": "PARK2 autoubiquitinates (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-517444", "l": "TAT aminates HPP (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5625870", "l": "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71958", "l": "glutarate(out) + 3 Na(+)(out) <=> glutarate(in) + 3 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60287", "l": "N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0071734", "l": "biotin-[pyruvate-carboxylase] ligase activity", "d": ["Catalysis of the reaction: ATP + biotin + apo-(pyruvate-carboxylase) = AMP + diphosphate + biotin-(pyruvate-carboxylase)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8952058", "l": "CCND1 binds RUNX3 and displaces EP300 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0098882", "l": "structural constituent of presynaptic active zone", "d": ["The action of a molecule that contributes to the structural integrity of a presynaptic active zone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24337", "l": "a carboxylate + ATP + CoA => AMP + an acyl-CoA + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3318413", "l": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76296", "l": "cob(I)alamin + S-adenosyl-L-methionine => methylcob(III)alamin + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73025", "l": "pregnenolone sulfate(in) => pregnenolone sulfate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70703", "l": "D-cycloserine(in) + H(+)(in) = D-cycloserine(out) + H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24816", "l": "2-oxoglutarate + L-valine <=> 3-methyl-2-oxobutanoate + L-glutamate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36749", "l": "beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + UDP => N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71306", "l": "chloride(out) + L-methionine(out) + 2 Na(+)(out) <=> chloride(in) + L-methionine(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77254", "l": "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70356", "l": "1-carboxybiuret + H(+) => biuret + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52385", "l": "L-glutamate + O-phospho-L-serine => H(+) + N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8868651", "l": "Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-71401", "l": "OGDH dimer decarboxylates 2-OG (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65364", "l": "a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O = a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(2),N(2),N(7)-trimethyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3222593", "l": "KDM6B demethylates H3K27me3 on p16INK4A promoter (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22163", "l": "4-coumaroyl-CoA + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside <=> a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193719", "l": "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76786", "l": "dodecan-1-ol + O2 + reduced [NADPH--hemoprotein reductase] <=> 1,9-dodecanediol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-70592", "l": "PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031819", "l": "P2Y10 nucleotide receptor binding", "d": ["Binding to a P2Y10 nucleotide receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36721", "l": "CoA + H(+) + N-hexacosenoylsphinganine => hexacosenoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70844", "l": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70778", "l": "6-sulfo-D-quinovose + FMNH2 + O2 <=> 6-dehydro-D-glucose + FMN + 2 H(+) + H2O + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62645", "l": "(5Z,8Z)-eicosadienoate + O2 => (5S)-hydroperoxy-(6E,8Z)-eicosadienoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-165758", "l": "Phosphorylation and inactivation of eEF2K by activated S6K1 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849797", "l": "Membrane proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6814153", "l": "ADO oxidises 2AET to HTAU (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-209532", "l": "The p75NTR C-terminal fragment enters endosomes (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.1.36", "l": "\"acetoacetyl-CoA reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-450550", "l": "PKCalpha phosphorylates HuR (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48947", "l": "ADP + bacteriochlorophyllide a + 2 oxidized [2Fe-2S]-[ferredoxin] + phosphate <=> 3-acetyl-3-devinylchlorophyllide a + ATP + H(+) + H2O + 2 reduced [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17347", "l": "CoA + H(+) + methylmalonate => (S)-methylmalonyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56728", "l": "4-hydroxy-all-trans-beta-carotene + AH2 + O2 = 4,4-dihydroxy-all-trans-beta-carotene + A + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11800", "l": "H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-70355", "l": "GALK1 phosphorylates Gal to Gal1P (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67825", "l": "a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O => a lipid X + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-75240", "l": "TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8   (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-507873", "l": "Aquaporins passively transport urea out of cells (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-5607735", "l": "p-Y753,Y759-PLCG2 hydrolyses PIP2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8853515", "l": "OTULIN,USP5 cleaves UBC yielding ubiquitin (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-917888", "l": "apoTF binds 2Fe3+ to form holoTF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3928631", "l": "GIT1 binds bPIX (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-75126", "l": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69898", "l": "cytidine(out) + Na(+)(out) <=> cytidine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72999", "l": "H2O + N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] = L-tryptophan + N-terminal L-alpha-aminoacyl-[peptide]", "d": [], "t": []}, {"i": "EC:3.4.11.17", "l": "\"tryptophanyl aminopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78723", "l": "3'-dehydromaltose + H2O = 3-dehydro-D-glucose + D-glucose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12490", "l": "2-dehydro-3-deoxy-D-gluconate + NH4(+) => 2-amino-2-deoxy-D-gluconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20567", "l": "(1S,2S,4R)-endo-fenchol + diphosphate => (2E)-geranyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72115", "l": "glycine betaine(out) + Na(+)(out) = glycine betaine(in) + Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57529", "l": "a 5'-end ribonucleotide-RNA + a ribonucleoside 5'-triphosphate + ATP + H2O => a 5'-end phospho-ribonucleoside-ribonucleotide-RNA + AMP + 2 diphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1675473", "l": "SH2B binds JAK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9705507", "l": "PDE3B hydrolyses cAMP to AMP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43400", "l": "N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose = H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097100", "l": "supercoiled DNA binding", "d": ["Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-9611751", "l": "β1,2-agonists bind ADRB1,2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8851396", "l": "NTPDase6 hydrolyzes nucleoside diphosphates (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-372449", "l": "SLC25A1 may exchange mitochondrial PEP for cytosolic anion (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-74715", "l": "Autophosphorylation of insulin receptor (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5692768", "l": "MAPKAPK5 phosphorylates KALRN (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34484", "l": "4-coumaroyl-CoA + H(+) + H2O + malonyl-CoA => 4-hydroxybenzalacetone + 2 CO2 + 2 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30518", "l": "S-adenosyl 3-(methylsulfanyl)propylamine + spermidine <=> H(+) + S-methyl-5'-thioadenosine + thermospermine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29147", "l": "2 H(+)(in) + nitrate + ubiquinol-8 = 2 H(+)(out) + H2O + nitrite + ubiquinone-8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23917", "l": "H(+) + UDP-alpha-D-glucuronate => CO2 + UDP-alpha-D-xylose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1483190", "l": "PETA and CTP are condensed to CDP-ETA by PCY2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2152276", "l": "Secretion of transmembrane collagens (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-749456", "l": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8961021", "l": "SFTPD binds with itself to form SFTPD 12mer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60346", "l": "H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine => L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62713", "l": "betaenone C + H(+) + NADPH + O2 => H2O + NADP(+) + stemphyloxin I", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8932851", "l": "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798743", "l": "Exocytosis of secretory granule membrane proteins (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56412", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1,2-ditetradecanoyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5666001", "l": "Profilin:G-actin binds MKL1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034910", "l": "6-hydroxy-3-succinoylpyridine hydrolase activity", "d": ["Catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-174120", "l": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8864577", "l": "TFAP2C translocates to the nucleus (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46101", "l": "11-deoxycortisol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => cortisol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1297338", "l": "Association of ADAM and B4GALT1 With ZP3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77947", "l": "1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate = 1,3-di-(10Z-heptadecenoyl)-glycerol + 9-(10Z-heptadecenoyloxy)-octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-392300", "l": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796047", "l": "PRKAA2 regulated nuclear export of NFE2L2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5218805", "l": "PKC autophosphorylates (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3371554", "l": "HSF1 acetylation at Lys80 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38846", "l": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50064", "l": "ATP + H2O + taurochenodeoxycholate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33993", "l": "alpha-copaene + diphosphate => (2E,6E)-farnesyl diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-507873", "l": "Aquaporins passively transport urea out of cells (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19984", "l": "NADP(+) + S-(hydroxymethyl)glutathione <=> H(+) + NADPH + S-formylglutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654653", "l": "Activated FGFR4 phosphorylates FRS3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5620921", "l": "ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75777", "l": "(10S)-hydroxy-(6Z,12Z)-octadecadienoate => (6Z,9Z,12Z)-octadecatrienoate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9757578", "l": "ALB binds PREDN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9701147", "l": "TRPV1 binds TRPV1 blockers (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-5665998", "l": "MKL1 binds SRF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "84.815870212838959", "identifiers": [{"i": "GO:0140327", "l": "flippase activity", "d": ["Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1482629", "l": "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.24.15", "l": "\"thimet oligopeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41291", "l": "H2O + N-dodecanoylsphing-4-enine = dodecanoate + sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-176585", "l": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8940074", "l": "NT5E:Zn2+ hydrolyses NMN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6786650", "l": "DDHD1,2 hydrolyse PA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9693347", "l": "HTR1A binds 5HT (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5694082", "l": "XK:KEL:Zn2+ cleaves EDN3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54216", "l": "2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1902417", "l": "(+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity", "d": ["Enables the transfer of (+)-abscisic acid D-glucopyranosyl ester from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28974", "l": "H(+)(in) + shikimate(in) <=> H(+)(out) + shikimate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33391", "l": "C20 sphinganine 1-phosphate + H2O = C20 sphinganine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74465", "l": "4'-methoxyviridicatin + H(+) + methyl isocyanate => (-)-4'-methoxycyclopenine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10394", "l": "(E)-cinnamaldehyde + H(+) + NADPH => (E)-cinnamyl alcohol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047187", "l": "deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity", "d": ["Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9014641", "l": "HRSP12 deaminates 2AA to 2OBUTA (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8870465", "l": "RGGT binds the RAB-binding subunit (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5635861", "l": "NUMB:ITCH binds GLI1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-201515", "l": "Active ALK recruits PI3K (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56137", "l": "2 a phenolic donor + H2O2 => 2 a phenolic radical donor + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70963", "l": "D-phenylalanine + H2O + O2 = 3-phenylpyruvate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9629216", "l": "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1638821", "l": "PP2A-B56 dephosphorylates centromeric cohesin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44464", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1-acyl-sn-glycerol = a 1,3-diacyl-sn-glycerol + a monoacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21438", "l": "[translation elongation factor 2]-phosphate + ADP + H(+) => [translation elongation factor 2] + ATP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39046", "l": "22-oxodocosanoate + O2 + reduced [NADPH--hemoprotein reductase] <=> docosanedioate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-994000", "l": "Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-191414", "l": "MVD decarboxylates MVA5PP to IPPP (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672843", "l": "AKT1S1 (PRAS40) binds mTORC1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18425", "l": "L-quinate + NADP(+) = 3-dehydroquinate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033738", "l": "methylenetetrahydrofolate reductase (ferredoxin) activity", "d": ["Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20408", "l": "H2O + N-acetyl-(2S,6S)-2,6-diaminoheptanedioate <=> (2S,6S)-2,6-diaminoheptanedioate + acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31185", "l": "3-oxododecanoyl-CoA + CoA => acetyl-CoA + decanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-416690", "l": "SEMA4A binds to PLXND1 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-482619", "l": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68806", "l": "alpha-D-glucose + D-glucose => H2O + kojibiose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-375487", "l": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63325", "l": "1,2-dihexadecanoyl-sn-glycerol + ATP => 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60183", "l": "ATP + D-fructose(out) + H2O <=> ADP + D-fructose(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6797554", "l": "ABP1 binds SHANK proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1483096", "l": "PETA is dephosphorylated to ETA by PHOSPHO1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20855", "l": "ATP + H(+)(in) + H2O <=> ADP + 2 H(+)(out) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9617595", "l": "SGTA binds mislocalized membrane protein (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-73564", "l": "UMPS dimer decarboxylates OMP to UMP (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42671", "l": "L-rhamnofuranose + NADP(+) <=> H(+) + L-rhamnono-1,4-lactone + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32786", "l": "ATP + glycine betaine(out) + H2O <=> ADP + glycine betaine(in) + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59565", "l": "H2O + N,N',N'',N'''-tetraacetylchitotetraono-1,5-lactone => H(+) + N,N',N'',N'''-tetraacetylchitotetraonate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2995330", "l": "COX10 transforms heme to heme O (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-77594", "l": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9796053", "l": "PRKCI phosphorylates NFE2L2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73243", "l": "S-adenosyl-L-methionine + scutellarein 7-methyl ether = cirsimaritin + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9839072", "l": "HTRA2 degrades APP (Amyloid-beta precursor protein) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55544", "l": "L-lysyl-[citrate synthase] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[citrate synthase] + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.48", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72640", "l": "1,6-dihydroxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-methionine => 1-hydroxy-6-methoxyphenazine N(5),N(10)-dioxide + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13532", "l": "(3S)-citramalate <=> H2O + mesaconate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16897", "l": "a 3beta-hydroxysteroid + a triacylglycerol = a 3beta-hydroxysteroid ester + a diacylglycerol", "d": [], "t": []}, {"i": "EC:2.3.1.77", "l": "\"triacylglycerol--sterol O-acyltransferase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008469", "l": "histone arginine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32171", "l": "H(+) + NADPH + O2 + phenylacetyl-CoA = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)", "d": [], "t": []}, {"i": "EC:1.14.13.149", "l": "\"phenylacetyl-CoA 1,2-epoxidase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8878143", "l": "RUNX3 binds SMAD3 and SMAD4 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15881", "l": "ATP + L-seryl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-seryl-[Fas-activated protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-109387", "l": "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2022887", "l": "NDST1-4 N-deacetylates GlcNAc residues in heparan (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8856813", "l": "AAK1 phosphorylates AP-2 mu subunit at T156 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5691167", "l": "CUL1, SKP1, FBXL5 bind (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47523", "l": "3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isolithocholate + NADP(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6788798", "l": "AK4 phosphorylates (d)NMPs to (d)NDPs (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17803", "l": "CoA + H(+) + N-acetyl-L-phenylalanine => acetyl-CoA + L-phenylalanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1675994", "l": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16627", "l": "CoA + thioacetate => acetyl-CoA + hydrogen sulfide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13248", "l": "D-threo-isocitrate <=> glyoxylate + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654418", "l": "Activated FGFR4 phosphorylates FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6784598", "l": "NPPA(124-151) binds NPR1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0016819", "l": "hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides", "d": ["Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-."], "t": []}, {"i": "EC:3.6.2.-", "l": "\"In sulfonyl-containing anhydrides\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.13.3", "l": "\"histidine kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15815", "l": "CoA + N-acetylimidazole => 1H-imidazole + acetyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38927", "l": "1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015048", "l": "phthalate dioxygenase reductase activity", "d": ["Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5658438", "l": "SPRED dimer binds NF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19222", "l": "2 formaldehyde + H2O => formate + H(+) + methanol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9726580", "l": "PGR binds PGR agonists (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10251", "l": "dUTP + H2O <=> diphosphate + dUMP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-112271", "l": "The receptor:G-protein complex dissociates (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14023", "l": "20-hydroxyecdysone + A + H2O => AH2 + ecdysone + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-373867", "l": "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27797", "l": "(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate <=> all-trans-heptaprenyl diphosphate + 4 diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-199046", "l": "Ligands bind L-selectin (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-193455", "l": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51183", "l": "cytidine(49) in tRNA(Asp) + S-adenosyl-L-methionine <=> 5-methylcytidine(49) in tRNA(Asp) + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28444", "l": "alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + holo-[ACP] => alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + dodecanoyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15831", "l": "a 16beta-hydroxysteroid => a 16alpha-hydroxysteroid", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46815", "l": "4,4-dimethyl-8,14-cholestadien-3beta-ol + H(+) + NADPH <=> 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36509", "l": "3-oxotetracosanoyl-CoA + CO2 + CoA => docosanoyl-CoA + H(+) + malonyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19550", "l": "H2O + o-orsellinate depside => H(+) + 2 orsellinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18467", "l": "5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde + H(+) => L-dopa + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5694126", "l": "NT5C3B hydrolyses 7MGP to 7MG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8871194", "l": "RAB5 and GAPVD1 bind AP-2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73691", "l": "3'-AMP(out) + phosphate(in) = 3'-AMP(in) + phosphate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62144", "l": "dGMP + dGTP = 2 dGDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27351", "l": "arseno-mycothiol + H2O => arsenate + mycothiol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4167511", "l": "HLCS biotinylates ACACB (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9861667", "l": "DLAT trimer transfers acetyl to CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34384", "l": "alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octa-cis-decaprenol + UDP-alpha-D-galactofuranose => beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octa-cis-decaprenol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6788392", "l": "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9017120", "l": "IK1 binds the PTCRA gene promoter (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45435", "l": "H2O + N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine <=> H(+) + N-(9Z-octadecenoyl) ethanolamine + sn-glycerol 3-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10064", "l": "(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + D-alanine + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine", "d": [], "t": []}, {"i": "EC:2.1.2.7", "l": "\"D-alanine 2-hydroxymethyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48039", "l": "a globoside Gb4Cer (d18:1(4E)) + H2O <=> a globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8950757", "l": "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-182988", "l": "Sprouty lures CBL away from EGFR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23553", "l": "2-methylpropane-1,2-diol + NAD(+) => 2-hydroxy-2-methylpropanal + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10977", "l": "H(+) + NADH + O2 + quinolin-2-ol => 5,6-dihydroquinoline-2,5,6-triol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70444", "l": "2-oxoglutarate + an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + O2 => a 2'-deoxyadenosine in double-stranded DNA + CO2 + formaldehyde + H(+) + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3321805", "l": "NSL acetylates histone H4 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619756", "l": "NR1H2 binds ABCA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8983845", "l": "p-STAT1 dissociates from IL6ST:IL6ST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42162", "l": "(5Z,11Z,14Z)-eicosatrienoyl-CoA + A + 2 H2O => (11Z,14Z)-eicosadienoyl-CoA + AH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052894", "l": "norspermine:oxygen oxidoreductase activity", "d": ["Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-507869", "l": "Aquaporins passively transport glycerol into cells (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68284", "l": "hexanoyl-CoA + L-seryl-[protein] = CoA + O-hexanoyl-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0031492", "l": "nucleosomal DNA binding", "d": ["Binding to the DNA portion of a nucleosome."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5668414", "l": "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5624473", "l": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40021", "l": "(-)-ent-copalol + diphosphate => ent-copalyl diphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28301", "l": "(2E,6E)-farnesyl diphosphate <=> (E)-gamma-bisabolene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47955", "l": "[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O <=> [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-175983", "l": "COMT transfer CH3 from AdoMet to 3,4DHBNZ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9717374", "l": "SCN3A:SCN2B,4B transports Na+ from the extracellular region to the cytosol (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21118", "l": "beta-D-glucose 1-phosphate + D-glucose => D-maltose + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5654637", "l": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19021", "l": "an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.40", "l": "\"glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41347", "l": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 <=> (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662986", "l": "MT2A binds copper (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009678", "l": "diphosphate hydrolysis-driven proton transmembrane transporter activity", "d": ["Catalysis of the reaction: diphosphate + H+(in) + H2O = 2 H+(out) + 2 phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-186778", "l": "SHP2 binds to the active receptor (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654612", "l": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482889", "l": "DAG is acylated to TAG by DGAT1/2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-167415", "l": "G-protein alpha subunit is inactivated (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45192", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 1-acyl-sn-glycero-3-phosphocholine + H(+) + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5140747", "l": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-9641096", "l": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-629596", "l": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-186780", "l": "PI3-kinase binds to the active receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27491", "l": "D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate => 2 D-sedoheptulose 7-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5623622", "l": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-176606", "l": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69728", "l": "2-phenylacetate + ATP + H(+) => diphosphate + phenylacetyl-AMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45372", "l": "H2O + N-(9Z-octadecenoyl)-sphinganine = (9Z)-octadecenoate + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63083", "l": "AH2 + ATP + ilicicolinate B <=> A + AMP + diphosphate + ilicicolin B", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32600", "l": "7-hydroxy-4-isopropenyl-7-methyloxepan-2-one => 3-isopropenyl-6-oxoheptanoate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2465940", "l": "atRAL is reduced to atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69668", "l": "H2O + luteolin 4'-O-beta-D-glucoside => beta-D-glucose + luteolin", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65650", "l": "a diacylglycerol + N-(28-(9Z,12Z-octadecadienoyloxy)-octacosanoyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + N-(28-hydroxyoctacosanoyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23481", "l": "2-methylene-3-methylsuccinate => dimethylmaleate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9021609", "l": "ESR-associated SRC autophosphorylates (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-211968", "l": "CYP2W1 oxidises INDOL (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2130336", "l": "Initial proteolyis of Ii by aspartic proteases to lip22 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-73912", "l": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-204662", "l": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-917936", "l": "MCOLN1 transports Fe2+ from endosome lumen to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9648114", "l": "EML4 recruits NUDC to mitotic spindle (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9770236", "l": "Formation of the Spliceosomal P complex and exon ligation (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9835328", "l": "NPM binds PKR (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1655453", "l": "FMO1:FAD oxidizes HTAU to TAU (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12956", "l": "ATP + L-seryl-[Goodpasture antigen-binding protein] <=> ADP + H(+) + O-phospho-L-seryl-[Goodpasture antigen-binding protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.7.1.14", "l": "\"2-hydroxy-6-oxonona-2,4-dienedioate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8942101", "l": "RNF20:RNF40 monoubiquitinates Histone H2B (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29056", "l": "a ubiquinone + 2 H(+)(in) + H2 => a ubiquinol + 2 H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11081", "l": "dTMP + H2O => phosphate + thymidine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43106", "l": "A + an N-acyleicosasphing-4-enine + 2 H2O => AH2 + an N-acyleicosasphinganine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9854672", "l": "FAD attaches to SDHA (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66887", "l": "O2 + reduced [NADPH--hemoprotein reductase] + tetradecanoate <=> 11-hydroxytetradecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6793661", "l": "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-383190", "l": "HCO3- transport through ion channel (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40278", "l": "hexadecanedioyl-CoA + O2 <=> (2E)-hexadecenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5656105", "l": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8937613", "l": "CRHBP binds CRH (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1482973", "l": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1183128", "l": "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0106267", "l": "3,5 dichloro-THPH synthase activity", "d": ["Catalysis of the reaction: (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O."], "t": []}, {"i": "RHEA:64360", "l": "(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047393", "l": "glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity", "d": ["Catalysis of the reaction: glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-201475", "l": "I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0033761", "l": "mugineic-acid 3-dioxygenase activity", "d": ["Catalysis of the reactions: mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-390304", "l": "acetyl-CoA + H2O => acetate + CoASH (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-170120", "l": "Translocation of Cdc25B to the cytoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54921", "l": "13-cis-retinol + NADP(+) => 13-cis-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8964246", "l": "BTK in G alpha (12)-BTK complex is activated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42229", "l": "17beta-estradiol + A => AH2 + estrone", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17929", "l": "an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+)", "d": [], "t": []}, {"i": "EC:2.7.1.138", "l": "\"ceramide kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034527", "l": "1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity", "d": ["Catalysis of the reaction: 1,2-dihydroxy-8-carboxynaphthalene + O2 = 2-carboxy-2-hydroxy-8-carboxychromene."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4641249", "l": "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10217", "l": "[DNA-directed RNA polymerase] + ATP => ADP + H(+) + phospho-[DNA-directed RNA polymerase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20090", "l": "acetyl-CoA + L-leucine => CoA + H(+) + N-acetyl-L-leucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-389354", "l": "Activation of Vav1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8986994", "l": "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5419261", "l": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17286", "l": "a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose => a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-909720", "l": "IFN alpha/beta binds to IFNAR2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-204364", "l": "ROBO1 binds SLIT2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14047", "l": "3-(hydrohydroxyphosphoryl)pyruvate + CO2 => 1-carboxyvinyl carboxyphosphonate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1903136", "l": "cuprous ion binding", "d": ["Binding to a cuprous ion, copper(1+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-71223", "l": "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46648", "l": "17-hydroxy-3-oxochol-4-en-22-oyl-CoA = androst-4-ene-3,17-dione + propanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047325", "l": "inositol tetrakisphosphate 1-kinase activity", "d": ["Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26565", "l": "2-succinylbenzoyl-CoA + H(+) <=> 1,4-dihydroxy-2-naphthoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1989772", "l": "Expression of GLIPR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-390593", "l": "ATP Hydrolysis By Myosin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59677", "l": "D-maltotetraose + O2 => D-maltotetraono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-111746", "l": "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15198", "l": "a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine => an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68775", "l": "(2Z,6Z)-farnesyl diphosphate <=> diphosphate + germacrene C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69077", "l": "(R)-noradrenaline + H2O + O2 => (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9822532", "l": "ADAMTS13 cleaves VWF multimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814121", "l": "PDCL binds G-protein beta and TRiC/CCT (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47114", "l": "glycochenodeoxycholate + H2O => chenodeoxycholate + glycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50601", "l": "acetyl-CoA + N-terminal L-seryl-[histone H2A] => CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[histone H2A]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855205", "l": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42462", "l": "biphenyl-2,2',3-triol + NAD(+) => dibenzofuran + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-3781926", "l": "Defective PMM2 does not isomerise Man6P to Man1P (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8855508", "l": "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-114354", "l": "SMAC binds XIAP:Caspase-7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71056", "l": "L-cysteine(out) + L-methionine(in) => L-cysteine(in) + L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36430", "l": "2-[(3S)-3-carboxy-3-(dimethylamino)propyl]-L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> diphthine-[translation elongation factor 2] + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25829", "l": "AH2 + an N-acyl-(4R)-4-hydroxysphinganine + O2 => A + a (4R,8E)-4-hydroxysphingenine ceramide + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0036009", "l": "protein-glutamine N-methyltransferase activity", "d": ["Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine."], "t": []}, {"i": "REACT:R-HSA-6800138", "l": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60310", "l": "2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine => L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5607746", "l": "PKC-delta is activated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59078", "l": "2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate + 2 GDP + 2 H(+) => bis(myo-inositol) 1,3'-phosphate + 2 GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22150", "l": "a plastoquinone + 4 H(+)(out) + 2 reduced [plastocyanin] => a plastoquinol + 2 H(+)(in) + 2 oxidized [plastocyanin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2029455", "l": "Cross-linking of FCGRIA with IgG-coated Ag (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73431", "l": "(2S)-sakuranetin + O2 + reduced [NADPH--hemoprotein reductase] = (2S)-7-methylcarthamidin + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31058", "l": "estrone 3-sulfate + H2O <=> estrone + H(+) + sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58612", "l": "2 L-ascorbate + N-octanoylglycine + O2 = H2O + 2 monodehydro-L-ascorbate radical + N-octanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004159", "l": "dihydropyrimidine dehydrogenase (NAD+) activity", "d": ["Catalysis of the reaction: a 5,6-dihydropyrimidine (5,6-dihydrouracil or 5,6-dihydrothymine) + NAD+ = a pyrimidine (uracil or thymine) + NADH + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1482811", "l": "DAG is hydrolyzed to 2-MAG by PNPLA2/3 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8864577", "l": "TFAP2C translocates to the nucleus (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55659", "l": "2 A + a carotenoid beta-end derivative <=> a carotenoid chi-end derivative + 2 AH2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9761858", "l": "NFE2L2-dependent TALDO1 gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-927836", "l": "SMG6 hydrolyzes mRNA with premature termination codon (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36654", "l": "8-desmethylnovobiocic acid + S-adenosyl-L-methionine <=> H(+) + novobiocic acid + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48894", "l": "L-threonyl-[protein] + N-acetyl-D-glucosamine => 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69897", "l": "cytidine(in) + Na(+)(in) => cytidine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52779", "l": "2-(L-cystein-S-yl)-2-(1H-indol-3-yl)-acetonitrile + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] <=> camalexin + CO2 + 2 H(+) + 4 H2O + hydrogen cyanide + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25066", "l": "(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8944232", "l": "Association of procollagen type XII (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.3.1.158", "l": "\"phospholipid:diacylglycerol acyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78083", "l": "1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = 1-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61497", "l": "an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose => an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70579", "l": "2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23177", "l": "acetate + ATP + CoA => acetyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49904", "l": "(1R,6R)-1,4,5,5a,6,9-hexahydrophenazine-1,6-dicarboxylate + H(+) + O2 = (1R,10aS)-1,4,10,10a-tetrahydrophenazine-1-carboxylate + CO2 + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9839388", "l": "TGFBR3 translocation to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25547", "l": "ent-copalyl diphosphate <=> diphosphate + ent-pimara-9(11),15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13351", "l": "methyl (-)-jasmonate + S-adenosyl-L-homocysteine => jasmonate + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52960", "l": "hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta-D-glucuronate) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31683", "l": "prosolanapyrone III = (-)-solanapyrone A", "d": [], "t": []}, {"i": "EC:5.5.1.20", "l": "\"prosolanapyrone-III cycloisomerase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004174", "l": "electron-transferring-flavoprotein dehydrogenase activity", "d": ["Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5626988", "l": "TNF-α:TNFR1 binds NSMAF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9007447", "l": "E2F6 forms the PRC1L4 complex (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50265", "l": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] => 26-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9704297", "l": "CHRM2 binds CHRM2 antagonists (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5654560", "l": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9606884", "l": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48928", "l": "CMP-N-acetyl-beta-neuraminate + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide = CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8878654", "l": "ACP6 hydrolyses MYS-LPA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-201636", "l": "Caspase-mediated cleavage of Desmoplakin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9836034", "l": "TFAP2A:TFAP2B binds the GBX2 gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58230", "l": "H(+) + N(4)-(ADP-D-ribosyl)-L-asparaginyl-[protein] + nicotinamide => L-asparaginyl-[protein] + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54397", "l": "1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4793911", "l": "MAPKAPK2 phosphorylates HSF1 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2002460", "l": "P4HB binds Collagen chains (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50766", "l": "4-methylamino-4-dedimethylamino-anhydrotetracycline + H(+) + S-adenosyl-L-homocysteine => 4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55411", "l": "[phosphate](n) + CTP <=> [phosphate](n+1) + CDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1067640", "l": "IL6 binds IL6R-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70449", "l": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9679740", "l": "ITGA4:ITGB1 binds natalizumab (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9823065", "l": "GPIb:IX:V binds to VWF multimer:collagen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2134519", "l": "TGFBR2 is recruited to tight junctions after TGF-beta stimulation (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77045", "l": "5-hydroxyoctan-4-one + H(+) + NADH + NH4(+) => 5-hydroxyoctan-4-amine + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1990053", "l": "DNA-5-methylcytosine glycosylase activity", "d": ["Catalysis of the reaction: DNA containing 5-methylcytosine + H2O = DNA with abasic site + 5-methylcytosine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the DNA 5-methylcytosine and the deoxyribose sugar to remove the 5-methylcytosine, leaving an abasic site."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49145", "l": "2-oxoglutarate + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose => dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8954056", "l": "E2F6 binds TFDP2 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72698", "l": "UDP-N-acetyl-alpha-D-glucosamine(in) + UMP(out) <=> UDP-N-acetyl-alpha-D-glucosamine(out) + UMP(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195287", "l": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1296037", "l": "Activation of Ca2+ activated Potassium channels with large conductance (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53594", "l": "1-tetradecanoyl-sn-glycerol + phosphate => 1-tetradecanoyl-sn-glycerol 3-phosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-6798374", "l": "DYRK2 phosphorylates TP53 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30403", "l": "Fe(3+)(out) + L-ascorbate(in) = Fe(2+)(out) + H(+) + monodehydro-L-ascorbate radical(in)", "d": [], "t": []}, {"i": "EC:7.2.1.3", "l": "\"ascorbate ferrireductase (transmembrane)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58762", "l": "1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+) => 1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54467", "l": "1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63670", "l": "(7R,8S)-8-amino-7-(carboxyamino)nonanoate + (S)-2-amino-6-oxohexanoyl-[protein] + 3 H(+) + NADPH => CO2 + H2O + N(6)-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysyl-[protein] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0043035", "l": "chromatin insulator sequence binding", "d": ["Binding to a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24408", "l": "adenosine + H(+) + H2O = inosine + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48506", "l": "D-glycero-D-manno-heptose 1-phosphate + phosphate => D-glycero-D-manno-heptose 1,7-bisphosphate + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41017", "l": "1-O-hexadecyl-2-acetyl-3-(9Z,12Z)-octadecadienoyl-sn-glycerol + CoA => (9Z,12Z)-octadecadienoyl-CoA + 1-O-hexadecyl-2-acetyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9013533", "l": "MPST transfers sulfur from sulfanegen to HCN to form HSCN (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36860", "l": "(17Z,20Z,23Z,26Z,29Z)-dotriacontapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(19Z,22Z,25Z,28Z,31Z)-tetratriacontapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-189442", "l": "ALAS condenses SUCC-CoA and Gly to form dALA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047073", "l": "2,4'-dihydroxyacetophenone dioxygenase activity", "d": ["Catalysis of the reaction: 2,4'-dihydroxyacetophenone + O2 = 4-hydroxybenzoate + formate + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2395314", "l": "Formation of lysino-5-ketonorleucine cross-links (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.6.7", "l": "\"cellulose-polysulfatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68511", "l": "(2E,6E)-farnesyl diphosphate <=> (Z)-beta-farnesene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49160", "l": "1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.1.1.149", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-8951644", "l": "Release of mature NEDD8 (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-114552", "l": "Thrombin-activated PARs activate G12/13 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-169260", "l": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63039", "l": "H2O + octadecanamide <=> NH4(+) + octadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6793275", "l": "CMVPP65 binds NCR3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-8964329", "l": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-75098", "l": "mRNP complex dissociates from cytosolic face of NPC (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114689", "l": "PLC gamma 2-mediated PIP2 hydrolysis (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25034", "l": "all-trans-retinol + NADP(+) => all-trans-retinal + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51565", "l": "cholest-4-en-3-one + 5 H(+) + 3 O2 + 6 reduced [2Fe-2S]-[ferredoxin] => (25S)-3-oxocholest-4-en-26-oate + 4 H2O + 6 oxidized [2Fe-2S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-425994", "l": "Na+/H+ exchanger transport (at cell membrane) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43331", "l": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP <=> 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-549297", "l": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5661120", "l": "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-170835", "l": "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Danio rerio)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5617815", "l": "BBSome binds RAB3IP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-8849969", "l": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.29", "l": "\"picornain 2A\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5635856", "l": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51664", "l": "D-5-phenylhydantoin + H2O = H(+) + N-carbamoyl-D-phenylglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31325", "l": "(2R)-2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-phospho-glycerate + GDP + H(+) => (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + GDP-alpha-D-mannose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60869", "l": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O => a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methyl-GDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19255", "l": "an N-acylsphing-4-enine + H(+) + phosphocholine => a sphingomyelin + H2O", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9603987", "l": "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424476", "l": "Activation of RAC1 by VAV2/3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050256", "l": "ribitol-5-phosphate 2-dehydrogenase [(NAD(P)+] activity", "d": ["Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "61.203114274332151", "identifiers": [{"i": "GO:0099094", "l": "ligand-gated monoatomic cation channel activity", "d": ["Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22737", "l": "5-formimidoyltetrahydrofolate + 2 H(+) => (6R)-5,10-methenyltetrahydrofolate + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12095", "l": "(S)-acetoin <=> (R)-acetoin", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.22.52", "l": "\"calpain-1\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59810", "l": "D-tyrosine => L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15887", "l": "(S)-lactaldehyde + H(+) + NADPH => NADP(+) + propane-1,2-diol", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11435", "l": "S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside <=> 7-O-methylvitexin 2''-O-beta-L-rhamnoside + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5684875", "l": "Binding of ATR:ATRIP to RPA at resected DNA DSBs (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56144", "l": "a quinol + nitrate = a quinone + H2O + nitrite", "d": [], "t": []}, {"i": "EC:1.7.5.1", "l": "\"nitrate reductase (quinone)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14778", "l": "AMP + H(+) + H2O => IMP + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50211", "l": "cortisol + NAD(+) <=> cortisone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6789960", "l": "Expression of NDN,TP53 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14129", "l": "cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.176", "l": "\"12alpha-hydroxysteroid dehydrogenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-109637", "l": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74017", "l": "CO2 + H2O + phenyl phosphate => 4-hydroxybenzoate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33385", "l": "(S)-malyl N-acetyl-alpha-D-glucosaminide + H(+) + UDP => (S)-malate + UDP-N-acetyl-alpha-D-glucosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11988", "l": "1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.79", "l": "\"cyclopropane-fatty-acyl-phospholipid synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.31", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9603419", "l": "Activated NTRK3 binds SRC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48419", "l": "a ganglioside GA2 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate <=> a ganglioside GM2 (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57084", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + H2O = a fatty acid + an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5692755", "l": "CDK1 phosphorylates MAPK6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-917700", "l": "MVB Vesicle Formation (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2454113", "l": "RBP3 transports 11cRAL to rod photoreceptor outer segment (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15127", "l": "CoA + H(+) + N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) => acetyl-CoA + alpha-D-glucosaminyl-[heparan sulfate](n)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5610727", "l": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110217", "l": "Cleavage of 5-hydroxyluracil by UNG glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33160", "l": "H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine => a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29124", "l": "nitrate(out) + ubiquinol-8(in) => H2O(out) + nitrite(out) + ubiquinone-8(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69030", "l": "5beta-androstane-3alpha,17beta-diol + NADP(+) => 5beta-dihydrotestosterone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-417858", "l": "P2Y14 receptor can bind to UDP-glucose (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9702849", "l": "CALCR binds gepants (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9606163", "l": "p-SYK and LYN phosphorylate BTK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-382054", "l": "PDGF binds to extracellular matrix proteins (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676607", "l": "sBAFF,sAPRIL binds TACI,BCMA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0008478", "l": "pyridoxal kinase activity", "d": ["Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62444", "l": "L-canavanine + L-ornithine = H(+) + L-arginine + L-canaline", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8950210", "l": "Interleukin-27 dissociates from Interleukin-27 receptor (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8951656", "l": "NEDD8-UBA3:NAE1 binds a second NEDD8 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1483002", "l": "DHAP is converted to 1-acyl GO3P by GNPAT (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2066787", "l": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76422", "l": "2-hydroxymethyl-3-pentylphenol + O2 + reduced [NADPH--hemoprotein reductase] <=> (8S)-annullatin E + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050121", "l": "N-acylglucosamine 2-epimerase activity", "d": ["Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-442314", "l": "VAV3 is a GEF for Rho/Rac family kinases (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73162", "l": "FMN(out) + NAD(+)(in) <=> FMN(in) + NAD(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57976", "l": "(20S)-protopanaxadiol + UDP-alpha-D-glucose = (20S)-ginsenoside C-K + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696183", "l": "AOC3 deaminates BZAM (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8982165", "l": "IL19:IL20RA:p‑JAK1:IL20RB binds STAT3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-110243", "l": "Excision of 8-oxoguanine by OGG1 glycosylase (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190429", "l": "Autocatalytic phosphorylation of FGFR1c (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5684864", "l": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9825759", "l": "MAPK-dependent phosphorylation of KARS (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015121", "l": "phosphoenolpyruvate:phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphoenolpyruvate(out) + phosphate(in) = phosphoenolpyruvate(in) + phosphate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71305", "l": "chloride(in) + L-methionine(in) + 2 Na(+)(in) => chloride(out) + L-methionine(out) + 2 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70712", "l": "D-alanine(in) => D-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3788061", "l": "Fibronectin degradation by ADAM8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35968", "l": "fumitremorgin C + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] => 12alpha,13alpha-dihydroxyfumitremorgin C + 2 H(+) + 2 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004581", "l": "dolichyl-phosphate beta-glucosyltransferase activity", "d": ["Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-507870", "l": "Aquaporins passively transport water out of cells (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-75174", "l": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-379044", "l": "Liganded Gs-activating GPCR acts as a GEF for Gs (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:37847", "l": "13-dihydrodaunorubicin + H(+) + NADPH + O2 = daunorubicin + 2 H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48619", "l": "H2O + leukotriene D4 <=> glycine + leukotriene E4", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-199917", "l": "MAPKAPK2 phosphorylates CREB at Serine 133 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015016", "l": "[heparan sulfate]-glucosamine N-sulfotransferase activity", "d": ["Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-420818", "l": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-8964604", "l": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-68595", "l": "ORC2 binds ORC3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-398184", "l": "LARG activation by G alpha 12/13 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38348", "l": "(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate => 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9014293", "l": "RAC2 GDIs block activation of RAC2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34526", "l": "[alpha-D-GalNAc-(1->4)]4-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + UDP-alpha-D-glucose <=> [alpha-D-GalNAc-(1->4)]2-[beta-D-Glc-(1->3)]-[alpha-D-GalNAc-(1->4)]2-alpha-D-GalNAc-(1->3)-alpha-D-diNAcBac-tri-trans,hepta-cis-undecaprenyl diphosphate + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53509", "l": "(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione => (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9647660", "l": "GSDME (1-270) binds PIPs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1234163", "l": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha  (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1234181", "l": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-6798174", "l": "PIK3C3:PIK3R4 phosphorylates PI to PI3P (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49053", "l": "asperlicin C + H(+) + NADH + O2 => asperlicin E + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49478", "l": "H(+) + L-2-aminoadipate + NADH => 2 H2O + L-1-piperideine-6-carboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-192341", "l": "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.923250621671642", "identifiers": [{"i": "GO:0019865", "l": "immunoglobulin binding", "d": ["Binding to an immunoglobulin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39195", "l": "3-oxotetracosanoyl-CoA + H(+) + NADPH = (3R)-hydroxytetracosanoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51029", "l": "2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 => 7-chloroindole-3-pyruvate imine dimer + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0004760", "l": "serine-pyruvate transaminase activity", "d": ["Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14000", "l": "3-methyl-2-oxobutanoate + CoA + NAD(+) <=> 2-methylpropanoyl-CoA + CO2 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65618", "l": "25-hydroxycholest-4-en-3-one + AH2 => A + cholest-4-en-3-one + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-388811", "l": "CD28 homodimer binds B7-1 homodimer (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052910", "l": "23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity", "d": ["Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5687109", "l": "MAPK4,6 translocate to the cytoplasm (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19257", "l": "a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-1564169", "l": "Collagen type VIII degradation by MMP1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-193703", "l": "IKKbeta is activated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11860", "l": "ATP + L-histidyl-[protein] = ADP + H(+) + N(tele)-phospho-L-histidyl-[protein]", "d": [], "t": []}, {"i": "EC:2.7.13.2", "l": "\"protein-histidine tele-kinase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9020252", "l": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9012654", "l": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds STAT5 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29245", "l": "menaquinol-8 + NAD(+) => H(+) + menaquinone-8 + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9631987", "l": "SLCO1B1 transports T3,T4 from extracellular region to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5607725", "l": "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18164", "l": "acetyl-CoA + tetradecanoyl-CoA <=> 3-oxohexadecanoyl-CoA + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-191323", "l": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-432049", "l": "Aquaporin-9 passively transports glycerol into cell (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3928615", "l": "EFNBs bind SFKs (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-389348", "l": "Activation of Rac1 by pVav1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102757", "l": "NADPH phosphatase activity", "d": ["Catalysis of the reaction: NADPH + H2O = NADH + hydrogenphosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34139", "l": "Delta(9)-tetrahydrocannabinolate + H(+) = CO2 + Delta(9)-tetrahydrocannabinol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8852298", "l": "GTSE1 binds MAPRE1 (EB1) at microtubule plus ends (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21665", "l": "4-nitrophenyl phosphate + H2O => 4-nitrophenol + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65255", "l": "(2E,6E)-farnesyl diphosphate + 6-hydroxymellein <=> diphosphate + verruculide C", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-163625", "l": "Glucagon binds to Glucagon receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19624", "l": "a nucleoside 2',3'-cyclic phosphate + H2O <=> a nucleoside 3'-phosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68206", "l": "1,2-dihexanoyl-3-octadecanoylglycerol + CoA => 1,2-dihexanoylglycerol + octadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1592436", "l": "Initial activation of proMMP9 by MMPs (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66434", "l": "H(+)(in) + L-galactose(in) => H(+)(out) + L-galactose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-111438", "l": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54872", "l": "(1S,4R)-menthone + H(+) + NADPH + O2 = (4S,7R)-7-isopropyl-4-methyloxepan-2-one + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-72691", "l": "Formation of the 43S pre-initiation complex (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66628", "l": "(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 = (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69291", "l": "(Z)-4-methylsufinylbutyl-N-(sulfonatooxy)methanimidothioate <=> sulfate + sulforaphane", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0086084", "l": "cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication", "d": ["Binding to a protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1067667", "l": "IL6 binds IL6R (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63270", "l": "1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine => 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022882", "l": "protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1676114", "l": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-888614", "l": "IDO2 dioxygenates L-Trp to NFK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-374723", "l": "Nociceptin receptor binds to nociceptin (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45682", "l": "N-(hexadecanoyl)-sphing-4-enine-1-phosphate(out) => N-(hexadecanoyl)-sphing-4-enine-1-phosphate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5687088", "l": "PKA phosphorylates MAPKAPK5 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016992", "l": "lipoate synthase activity", "d": ["Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.18.3.1", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-110137", "l": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9647980", "l": "mature RAS proteins translocate to plasma membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6800490", "l": "ATM phosphorylates PIDD1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-71155", "l": "TAT deaminates tyrosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:24496", "l": "4-O-deacetylvindoline + acetyl-CoA = CoA + vindoline", "d": [], "t": []}, {"i": "EC:2.3.1.107", "l": "\"deacetylvindoline O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-844447", "l": "NLRP1 senses MDP (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-5672008", "l": "Thr-180 of ULK1 is phosphorylated (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65807", "l": "a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O <=> a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+) + L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2046097", "l": "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9709842", "l": "MAVS binds TOMM70 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0016826", "l": "hydrolase activity, acting on acid sulfur-nitrogen bonds", "d": ["Catalysis of the hydrolysis of any acid sulfur-nitrogen bond."], "t": []}, {"i": "EC:3.10.-.-", "l": "\"Acting on sulfur-nitrogen bonds\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38237", "l": "1-O-octadecyl (9Z)-octadecenoate + CoA => (9Z)-octadecenoyl-CoA + octadecan-1-ol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33345", "l": "2-iminoacetate + H2O2 => glycine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-350604", "l": "Agmatine + H2O <=> putrescine + urea (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41766", "l": "a ganglioside GT3 (d18:1(4E)) + CMP + H(+) => a ganglioside GD3 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75651", "l": "(10R)-hydroperoxy-(8E,12Z,15Z)-octadecatrienoate = 12,13-epoxy-(10R)-hydroxy-(8E,15Z)-octadecadienoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48014", "l": "2-hydroxy-5-methylquinone + H(+) + H2O + NADP(+) + nitrite => 4-methyl-5-nitrocatechol + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45125", "l": "acarbose + ATP => acarbose 7(IV)-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.23.14", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-8933635", "l": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78089", "l": "2-acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+) => 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8856945", "l": "PP2A methylation by LCMT1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047789", "l": "creatininase activity", "d": ["Catalysis of the reaction: creatinine + H2O = creatine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9020277", "l": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63402", "l": "Fe(II)-heme a + H2O => Fe(II)-hydroxyheme i", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21233", "l": "L-histidine => NH4(+) + trans-urocanate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55615", "l": "an N(1)-methyl-2'-deoxyadenosine in double-stranded DNA + H2O <=> 1-methyladenine + a 2'-deoxyribose 5'-phosphate in double-stranded DNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5675433", "l": "PP5 dephosphorylates RAF1 S338 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:4.4.1.8", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8855375", "l": "PTPN22 dissociates from CSK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389821", "l": "glycine + O2 => glyoxylate + H2O2 + NH4+ (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76546", "l": "N-acetyl-S-(2-succino)-L-cysteine <=> fumarate + N-acetyl-L-cysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8981610", "l": "Neuroglobin binds oxygen (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40858", "l": "FAD + H(+) + undecanoyl-CoA <=> FADH2 + trans-2-undecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19367", "l": "ADP + D-ribulose 1,5-bisphosphate + H(+) => ATP + D-ribulose 5-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-873926", "l": "IFNG dimer binds IFNGR (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42933", "l": "cytidine(32) in tRNA + S-adenosyl-L-methionine => 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9023912", "l": "AGO2 cleaves passenger strand of duplex siRNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034828", "l": "4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity", "d": ["Catalysis of the reaction: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H2O = 2-hydroxydec-2,4-diene-1,10-dioate + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23046", "l": "(E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O => H(+) + N,N-dihydroxy-L-tyrosine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-74743", "l": "Dissociation of p-Y427-SHC1 from insulin receptor (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2162194", "l": "COQ7:COQ9 octamer hydroxylates DMQ10H2 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55530", "l": "(4-hydroxyphenyl)acetaldehyde + CO2 + H2O2 + NH4(+) => H(+) + H2O + L-tyrosine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-70523", "l": "PXLP-K314-GPT transaminates L-Ala to form PYR (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1855224", "l": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-507775", "l": "PXLP-K341-GPT2 transaminates L-Ala to form PYR (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8964271", "l": "BTK in PIP3:BTK:G beta-gamma complex is activated (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54975", "l": "1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-[ACP] <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45982", "l": "9alpha-hydroxy-3-oxochol-4-en-22-oyl-CoA + H2O + NAD(+) => 3-oxochol-4-en-22-oyl-CoA + H(+) + NADH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9855910", "l": "USF1 is phosphorylated by p-MAPK14 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9734730", "l": "ORC1 translocates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72966", "l": "acetoacetate(out) + 2 Na(+)(out) <=> acetoacetate(in) + 2 Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53891", "l": "D-glucose 6-phosphate + TDP-alpha-D-glucose <=> alpha,alpha-trehalose 6-phosphate + H(+) + TDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48203", "l": "H(+) + oxidized [electron-transfer flavoprotein] + undecanoyl-CoA <=> reduced [electron-transfer flavoprotein] + trans-2-undecenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390252", "l": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41201", "l": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + pentanoate => 1-hexadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2250301", "l": "Formation of lysyl-pyrrole cross-links (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63590", "l": "prunetin-4'-O-beta-D-glucuronide + UDP => prunetin + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-170149", "l": "Translocation of active Cdc25C to the nucleus (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36549", "l": "CoA + H(+) + N-(octadecanoyl)-sphinganine => octadecanoyl-CoA + sphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31645", "l": "H(+) + mycinamicin III + S-adenosyl-L-homocysteine => mycinamicin VI + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58821", "l": "H(+) + malonate + Na(+)(in) => acetate + CO2 + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3662318", "l": "Type B histone acetlytransferase complex acetylates histone H4 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12610", "l": "mercaptopurine + S-adenosyl-L-methionine => 6-methylthiopurine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9013435", "l": "RHOD auto-activates (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43402", "l": "H(+) + N-(2-hydroxy-hexanoyl)-beta-D-galactosyl-sphing-4-enine + UDP => N-(2-hydroxy-hexanoyl)-sphing-4-enine + UDP-alpha-D-galactose", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52174", "l": "11,12-epoxy-(5Z,8Z,14Z,17Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18941", "l": "a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) = a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.1.1.413", "l": "\"A-factor type gamma-butyrolactone 1'-reductase (1S-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47011", "l": "[DsrC protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide <=> [DsrC protein]-dithiol + 2 AH2 + H(+) + sulfite", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9663354", "l": "SLC26A5 (prestin) changes conformation in response to depolarization (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40669", "l": "2-iminopropanoate => 2-aminoprop-2-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9835121", "l": "Heparin binds PKR (Sus scrofa)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73615", "l": "CTP(out) + dCMP(in) = CTP(in) + dCMP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35214", "l": "dIDP + H2O <=> dIMP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.5.7.3", "l": "\"N,N-dimethylglycine/sarcosine dehydrogenase (ferredoxin)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25195", "l": "3-methylcatechol + H(+) + NADH => (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78645", "l": "(2E)-tetradecenoyl-CoA + H2O => (3R)-hydroxytetradecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22444", "l": "(E)-coniferol + NADP(+) = (E)-coniferaldehyde + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1632843", "l": "AMBRA1 binds DYNLL1,DYNLL2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-3229102", "l": "p-MAPKAPK3 phosphorylates BMI1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9627104", "l": "XIAP binds CASP3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-1614614", "l": "Cysteine is degraded to serine and H2S (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-2473184", "l": "Follistatin (FST) binds Activin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69977", "l": "(22S,24R)-22-hydroxy-5alpha-ergostan-3-one + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] => 6-deoxycathasterone + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46066", "l": "(6Z,11E)-octadecadienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O => (11E)-octadecenoyl-CoA + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58163", "l": "ent-copalyl diphosphate <=> diphosphate + dolabradiene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8849094", "l": "ARHGAP35 binds RASA1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6807224", "l": "Furin cleaves pro-BGLAP to BGLAP (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57396", "l": "(S)-S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine = 3-O-acetylpapaveroxine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.352", "l": "\"3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36109", "l": "O-methyl gibberellin A4 + S-adenosyl-L-homocysteine => gibberellin A4 + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-351210", "l": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13451", "l": "2-oxoglutarate + H(+) + NADH => 2-hydroxyglutarate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64030", "l": "H(+) + holo-[aryl-carrier protein] + N(1)-(3,4-dihydroxybenzoyl)-N(8)-citryl-spermidine => 3,4-dihydroxybenzoyl-[aryl-carrier protein] + N(8)-citryl-spermidine", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5205798", "l": "PRMT1,PRMT6 methylate arginine-4 of histone H4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-68919", "l": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0000285", "l": "1-phosphatidylinositol-3-phosphate 5-kinase activity", "d": ["Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-400015", "l": "Diacylgycerol activates Protein kinase C, alpha type (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32562", "l": "(2E)-geranyl diphosphate <=> diphosphate + gamma-terpinene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14975", "l": "D-aspartate => L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5633256", "l": "FABP5:atRA translocates from cytosol to nucleoplasm (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40760", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoylglycerone 3-phosphate => 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerone 3-phosphate + hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-879358", "l": "AGER-1,2,3 bind AGEs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5676596", "l": "TRAF3 binds BAFFR:BAFF (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9822539", "l": "VWF multimer binds to collagen type I (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696080", "l": "ALDH3B1 oxidises HXAL to PALM (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9834807", "l": "ILF3 binds PKR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9028730", "l": "Activated NTRK2 binds FRS2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2176445", "l": "SMURF2 binds SMAD2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.5.4.7", "l": "\"ADP deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389652", "l": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2465919", "l": "AWAT2 transfers PALM to 11cROL forming 11cRPALM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8964284", "l": "BTK in active Gq-BTK complex is activated (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55245", "l": "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 5 H(+) + 3 O2 => 4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14084", "l": "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate <=> D-glyceraldehyde 3-phosphate + indole", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28199", "l": "(S)-1-phenylethanol + NAD(+) => acetophenone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-3159253", "l": "MMAB adenosylates cob(I)alamin (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-2046092", "l": "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.11.21", "l": "\"clavaminate synthase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27404", "l": "2-hydroxychromene-2-carboxylate <=> (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8870499", "l": "PLEKHA3,8 bind PI4P, ARF1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-388829", "l": "SHP2 phosphatase binds CTLA-4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48040", "l": "a globoside Gb4Cer + H2O = a globoside Gb3Cer + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9832183", "l": "Expression of IRX1 during nephron development (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2033486", "l": "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-482772", "l": "Release of platelet cytosolic components (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5696968", "l": "USP20, USP33 deubiquitinate ADRB2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034450", "l": "ubiquitin-ubiquitin ligase activity", "d": ["Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-1630306", "l": "GLB1 hydrolyses a glycosaminoglycan (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9629195", "l": "NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.2.6", "l": "\"nucleoside deoxyribosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0099099", "l": "G-protein gated monoatomic ion channel activity", "d": ["An ion channel activity that is gated by binding of a G-protein beta-gamma dimer."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76602", "l": "(9Z,12Z)-octadecadienoate + H2O <=> (12Z)-10-hydroxyoctadecenoate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-4332358", "l": "Dissociation of CaM and CAMK2 autophosphorylation (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:27977", "l": "6-carboxy-5,6,7,8-tetrahydropterin + H(+) <=> 7-carboxy-7-deazaguanine + NH4(+)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814094", "l": "ARL1:GTP binds ARFIP2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76646", "l": "xanthine(out) <=> xanthine(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047952", "l": "glycerol-3-phosphate dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-351207", "l": "Spermine  => N-acetylated spermine (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46601", "l": "[HPr protein]-L-serine + ATP => [HPr protein]-O-phospho-L-serine + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2162066", "l": "carbovir + IMP => carbovir monophosphate + inosine (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0140838", "l": "RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity", "d": ["Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) cis-proline (omega=180) = RNA polymerase II large subunit trans-proline (omega=0)."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693574", "l": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34765", "l": "(S,S)-tartrate(in) + succinate(out) => (S,S)-tartrate(out) + succinate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53068", "l": "4-methoxyestrone + UDP-alpha-D-glucuronate = 4-methoxyestrone 3-O-(beta-D-glucuronate) + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9627106", "l": "SMAC (DIABLO) forms dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9005980", "l": "IL21 binds IL21R:JAK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31634", "l": "2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + H2O + phosphoenolpyruvate <=> phosphate + pseudaminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45738", "l": "(2E)-hexenoyl-CoA => (3E)-hexenoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77749", "l": "a 1-acyl-sn-glycero-3-phosphoethanolamine + a triacylglycerol => a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16238", "l": "[protein]-peptidylproline (omega=180) => [protein]-peptidylproline (omega=0)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1675928", "l": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9656244", "l": "DRD2 binds DA (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42219", "l": "(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) <=> 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72677", "l": "CMP + H(+) => 3',5'-cyclic CMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0034836", "l": "6-hydroxy-2-mercaptobenzothiazole monooxygenase activity", "d": ["Catalysis of the reaction: 6-hydroxy-2-mercaptobenzothiazole + 1/2 O2 = 6,7-dihydroxy-2-mercaptobenzothiazole."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8983371", "l": "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0102244", "l": "3-aminopropanal dehydrogenase activity", "d": ["Catalysis of the reaction: 3-ammoniopropanal + NAD + H2O = 2 H+ + beta-alanine + NADH."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-4419948", "l": "CTDNEP1:CNEP1R1 dephosphorylates LPIN (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-419011", "l": "Transhomodimerization of Nectins (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9656209", "l": "Dissociation of RAS:RAF1 mutant complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-984606", "l": "Kinesin-5 is a homotetramer (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1236967", "l": "Alkalization of the phagosomal lumen by NOX2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29558", "l": "H2O + UDP-alpha-D-glucose <=> alpha-D-glucose 1-phosphate + 2 H(+) + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34823", "l": "(E)-feruloyl-CoA + (E)-feruloylacetyl-CoA + H2O = CO2 + 2 CoA + curcumin", "d": [], "t": []}, {"i": "EC:2.3.1.217", "l": "\"curcumin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29498", "l": "(2E,6E)-farnesyl diphosphate + H2O <=> beta-eudesmol + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-266204", "l": "Association of HMGB1/HMGB2 with chromatin (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2066788", "l": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51410", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine => 1,2-dihexadecanoyl-sn-glycero-3-phospho-(N-hexadecanoyl)-ethanolamine + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75809", "l": "Na(+)(in) + propanoate(in) => Na(+)(out) + propanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-2294580", "l": "PLK1 hyperphosphorylates Condensin II complex (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-2396007", "l": "IRF3 is phosphorylated by TBK1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70539", "l": "GDP-beta-L-fucose + L-threonyl-[EGF-like domain protein] = 3-O-(alpha-L-fucosyl)-L-threonyl-[EGF-like domain protein] + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-76576", "l": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-2161613", "l": "PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9023633", "l": "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-6811417", "l": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10127", "l": "H(+) + NADPH + O2 + phenylacetone <=> benzyl acetate + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2424252", "l": "COMP binds collagen, fibronectin, aggrecan and matrilins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12430", "l": "benzene-1,2,4-triol + NAD(+) => 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65694", "l": "a diacylglycerol + an N-(omega-(9Z,12Z-octadecadienoyloxy)-ultra-long chain fatty acyl)-sphing-4-enine => a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol + an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphing-4-enine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-196929", "l": "FLAD1 phosphorylates FMN (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73842", "l": "ATP + H2O + phenol <=> AMP + 2 H(+) + phenyl phosphate + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67733", "l": "uridylyl-uridylyl-ribonucleotide-RNA => a 3'-end uridylyl-2',3'-cyclophospho-uridine-RNA + a 5'-end dephospho-ribonucleoside-RNA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-448629", "l": "IL33 binds IL1RL1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5693580", "l": "Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68669", "l": "16alpha,17beta-estriol 3-O-(beta-D-glucuronate) + 3'-phosphoadenylyl sulfate => 16alpha,17beta-estriol 3-O-(3-sulfo-beta-D-glucuronate) + adenosine 3',5'-bisphosphate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31953", "l": "9beta-pimara-7,15-dien-19-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] => 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46288", "l": "(9Z,12Z,15Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-877187", "l": "P2X7 mediates loss of intracellular K+ (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59477", "l": "2 AH2 + 2 ATP + benzoate + L-phenylalanine => 2 A + 2 AMP + 2 diphosphate + H(+) + N-benzoyl-L-phenylalaninol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.14.-", "l": "\"Dipeptidyl-peptidases and tripeptidyl-peptidases\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22053", "l": "A + H2O + NH4(+) => AH2 + H(+) + hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9647631", "l": "GSDMD (1-275) binds PIPs (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78041", "l": "1-O-alkyl-3-acylglycerol + a 1-acyl-sn-glycero-3-phosphocholine => 1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69967", "l": "Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55973", "l": "acetyl-CoA + ethanol => CoA + ethyl acetate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6799197", "l": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61817", "l": "16,17-didehydropregnenolone + UDP-alpha-D-glucose => 16,17-didehydropregnenolone 3-beta-D-glucoside + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9697051", "l": "RTC binds NRTIs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45561", "l": "L-isoleucine => D-allo-isoleucine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-111264", "l": "Addition of nucleotides between position +11 and +30 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110226", "l": "Cleavage of cytosine glycol by NTHL1 glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-202443", "l": "Oligomerization of CARMA1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050572", "l": "L-idonate 5-dehydrogenase [NAD(P)+] activity", "d": ["Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-166753", "l": "Conversion of C4 into C4a and C4b (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70821", "l": "L-homoarginine(out) + L-ornithine(in) => L-homoarginine(in) + L-ornithine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44123", "l": "hexadecanoyl-CoA + octadecan-1-ol <=> CoA + octadecanyl hexadecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46036", "l": "2'-deoxycytidine + UTP = dCMP + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17008", "l": "ATP + D-glucuronate <=> 1-phospho-alpha-D-glucuronate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-190681", "l": "Connexin oligomerization in endoplasmic reticulum membrane (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-381111", "l": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61021", "l": "acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA => 5'-deoxyadenosine + 5-(carboxymethyl)uridine(34) in tRNA + CoA + 2 H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:50918", "l": "AMP + an aldehyde + diphosphate + NADP(+) => a carboxylate + ATP + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-114263", "l": "Oligomerization  of BAK at the mitochondrial membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5661039", "l": "Defective SLC9A6 does not exchange Na+ for H+ across the early endosome membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6810238", "l": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008839", "l": "4-hydroxy-tetrahydrodipicolinate reductase", "d": ["Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21268", "l": "(R)-canadine + 2 NADP(+) = berberine + H(+) + 2 NADPH", "d": [], "t": []}, {"i": "EC:1.5.1.31", "l": "\"berberine reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-442291", "l": "VAV2 is a GEF for Rho/Rac family kinases (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8849906", "l": "SALM1 binds NMDA receptor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74051", "l": "D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-158860", "l": "SULT1A1 dimer sulfonates NHABP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9762093", "l": "BTRC binds p-S344, 347 NFE2L2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51527", "l": "(S)-corytuberine + S-adenosyl-L-methionine <=> magnoflorine + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69716", "l": "(indol-3-yl)acetate + ATP + CoA => (indol-3-yl)acetyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66000", "l": "(6S)-5,6,7,8-tetrahydrofolate + methyl-Co(III)-[glycine betaine-specific corrinoid protein] = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + Co(I)-[glycine betaine-specific corrinoid protein] + H(+)", "d": [], "t": []}, {"i": "EC:2.1.1.378", "l": "\"[methyl-Co(III) glycine betaine-specific corrinoid protein]--tetrahydrofolate methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5336182", "l": "GPR37 binds prosaptide (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9697750", "l": "RIPK1 is cleaved by CASP8:FLIP(L) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45861", "l": "12-hydroxyoctadecanoyl-CoA + 2 H(+) + 2 malonyl-CoA => 4-hydroxy-6-(11-hydroxyheptadecyl)-pyran-2-one + 2 CO2 + 3 CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-209960", "l": "Diiodinated tyrosine can be deiodinated (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-3295579", "l": "TRPs transport extracellular Ca2+ to cytosol (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48283", "l": "a ganglioside GM2 + UDP-alpha-D-galactose <=> a ganglioside GM1 + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004306", "l": "ethanolamine-phosphate cytidylyltransferase activity", "d": ["Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8950342", "l": "EBI3:CANX binds IL27 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62916", "l": "an N-terminal L-alpha-aminoacyl-[protein] + 3 S-adenosyl-L-methionine = an N-terminal trimethyl-L-alpha-aminoacyl-[protein] + 3 H(+) + 3 S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-433131", "l": "NaDC1 co-transports dicarboxylic acids and a sodium ion (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47327", "l": "(S)-3-amino-3-phenylpropanoate + pyruvate <=> 3-oxo-3-phenylpropanoate + L-alanine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67960", "l": "4-amino-L-phenylalanine + S-adenosyl-L-methionine = 4-methylamino-L-phenylalanine + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44416", "l": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-162830", "l": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3249370", "l": "p-S407,Y641-STAT6 dimer migrates to the nucleus (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-391943", "l": "CYSLT2 binds LTC4,LTD4,LTE4 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65521", "l": "all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] => all-trans-3-hydroxyretinol + H2O + 2 oxidized [adrenodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61918", "l": "ADP + fluconazole(out) + H(+) + phosphate => ATP + fluconazole(in) + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5662466", "l": "XYLB phosphorylates D-xylulose (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429767", "l": "Passive I- efflux mediated by SLC5A8 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21136", "l": "(R)-carnitine + acetyl-CoA = CoA + O-acetyl-(R)-carnitine", "d": [], "t": []}, {"i": "EC:2.3.1.7", "l": "\"carnitine O-acetyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78694", "l": "[(1->2)-beta-D-glucosyl](n) + a D-glucoside <=> [(1->2)-beta-D-glucosyl](n-1) + a beta-D-glucosyl-(1->2)-D-glucoside", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-209910", "l": "Iodide is taken up by thyroid epithelial cells (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29361", "l": "phosphate + uridine => H2O + UMP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:34063", "l": "2-deoxystreptamine + UDP-alpha-D-glucose = 2'-deamino-2'-hydroxyparomamine + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.284", "l": "\"2-deoxystreptamine glucosyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53752", "l": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-[beta-D-glucopyranosyl-(1->6)-beta-D-galactopyranosyl]-sn-glycerol + H(+) + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46908", "l": "a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + a 1,2-diacyl-sn-glycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:65314", "l": "a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP] => an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H(+) + malonyl-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49441", "l": "(R)-2-hydroxy-4-methylpentanoate + 4-methylpentanoyl-CoA => (R)-2-hydroxy-4-methylpentanoyl-CoA + 4-methylpentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1791102", "l": "Expression of C19orf10 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12628", "l": "(S)-malate + 1-O-(trans-sinapoyl)-beta-D-glucose <=> D-glucose + sinapoyl (S)-malate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53233", "l": "desmosterol + O2 + reduced [NADPH--hemoprotein reductase] => (24S)-25-epoxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15283", "l": "5alpha-cholest-8-en-3beta-ol => lathosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12712", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-9660557", "l": "RAS:GTP binds RAL GDS proteins (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52013", "l": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA => 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16092", "l": "H2O + phosphoethanolamine <=> ethanolamine + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5654701", "l": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5654594", "l": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12859", "l": "L-glutamate => (2S,3S)-3-methyl-L-aspartate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-190265", "l": "FGFR4 binds to FGF (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-113414", "l": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57390", "l": "(13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983153", "l": "E1 mediated ubiquitin activation (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050203", "l": "oxalate-CoA ligase activity", "d": ["Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H+ + oxalyl-CoA."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9733973", "l": "Bile salts bind FABP6 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8848246", "l": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9683653", "l": "Spike protein gets palmitoylated (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-947499", "l": "Exchange of oxygen with sulfur in MoCo (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2022368", "l": "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-42) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-110227", "l": "Cleavage of dihydrouracil by NTHL1 glycosylase (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19188", "l": "glyoxylate + H2O + propanoyl-CoA <=> 2-hydroxyglutarate + CoA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61744", "l": "steviolbioside + UDP-alpha-D-glucose = stevioside + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39496", "l": "3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + H(+) + NADPH => (3R)-hydroxy-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.1.3.29", "l": "\"N-acylhexosamine oxidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-901074", "l": "MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-76354", "l": "Vinyl chloride is oxidized to 2-Chloroethylene oxide (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19746", "l": "3,3',5-triiodo-L-thyronine + A + H(+) + iodide => AH2 + L-thyroxine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51764", "l": "dimethylallyl diphosphate + phlorisovalerophenone = 4-prenylphlorisovalerophenone + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78038", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol <=> a 1,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-4084982", "l": "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38050", "l": "a (9Z)-octadecenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a (9Z,12E)-octadecadienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17814", "l": "D-altronate + NAD(+) => H(+) + keto-D-tagaturonate + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9012319", "l": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9839149", "l": "AFG3L2 binds mitochondrial matrix proteins (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54459", "l": "1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O <=> 1-tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-445704", "l": "Calcium Binds Caldesmon (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-166215", "l": "FA spontaneously flip-flops back to the matrix side (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-5649673", "l": "NEIL1 cleaves FapyA from damaged DNA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29759", "l": "octanoate(in) = octanoate(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047054", "l": "berbamunine synthase activity", "d": ["Catalysis of the reaction: (S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH--hemoprotein reductase] + O2 = berbamunine + [oxidized NADPH--hemoprotein reductase] + 2 H2O."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-2162188", "l": "COQ5 methylates MDMQ10H2 (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49162", "l": "2-exo-hydroxy-1,4-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => 1,4-cineole + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:35883", "l": "(9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70985", "l": "glycine(in) + n H(+)(out) => glycine(out) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1497869", "l": "Salvage - Sepiapterin is reduced to BH2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8866277", "l": "AP-2 directly binds some endocytic cargo (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63331", "l": "2-(9Z-octadecenoyl)-glycerol + ATP <=> 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.4.18", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0032139", "l": "dinucleotide insertion or deletion binding", "d": ["Binding to a double-stranded DNA region containing a dinucleotide insertion or deletion."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8849082", "l": "ARHGAP35 stimulates RHOA GTPase activity (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.7.94", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-204434", "l": "BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69725", "l": "(indol-3-yl)acetyl-CoA + AMP + H(+) => (indol-3-yl)acetyl-AMP + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-419197", "l": "Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.7.8.21", "l": "\"membrane-oligosaccharide glycerophosphotransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9025996", "l": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-173647", "l": "Transport of trimeric gp41:gp120 to plasma membrane (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9609742", "l": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-446870", "l": "Polyubiquitinated TRAF6 binds the TAK1 complex (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40987", "l": "EDTA + 2 FMNH2 + 2 O2 = ethylenediaminediacetate + 2 FMN + 2 glyoxylate + 3 H(+) + 2 H2O", "d": [], "t": []}, {"i": "EC:1.14.14.33", "l": "\"ethylenediaminetetraacetate monooxygenase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:26131", "l": "(+)-copalyl diphosphate <=> diphosphate + isopimara-7,15-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76971", "l": "1-(9Z-octadecenoyl)-2-(7Z,10Z,13Z,16Z,19Z-docosapentaenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H2O = (9Z)-octadecenoate + 2-(7Z,10Z,13Z,16Z,19Z-docosapentaenoyl)-sn-glycero-3-phospho-1D-myo-inositol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58084", "l": "1-(13Z-docosenoyl)-glycerol + H2O = (13Z)-docosenoate + glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8932243", "l": "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56384", "l": "(1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + chloride + FADH2 + O2 = (5-chloro-1H-pyrrole-2-carbonyl)-[peptidyl-carrier protein] + FAD + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-1855227", "l": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41363", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine <=> H(+) + hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9830668", "l": "LHX1 binds the NPNT gene (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52642", "l": "(2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + CoA => (2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl-(1->2)]-glycerate + octanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174105", "l": "Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51378", "l": "CoA + H(+) + N-hexadecanoyl-dopamine => dopamine + hexadecanoyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0103082", "l": "2-(4'-methylthio)butylmalate synthase activity", "d": ["Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + acetyl-CoA + H2O = H+ + 2-(4'-methylthio)butylmalate + coenzyme A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56076", "l": "an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-75862", "l": "Fall Back to Closed Pre-initiation Complex (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33851", "l": "GDP-alpha-D-mannose + N-tetracosanoylsphinganine-(1D-myo-inositol) = GDP + H(+) + mannosyl-alpha-1->6-inositol phospho-N-tetracosanoylsphinganine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12524", "l": "L-pipecolate + NADP(+) = Delta(1)-piperideine-2-carboxylate + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61280", "l": "4-aminobutanoate + H2O + O2 = H2O2 + NH4(+) + succinate semialdehyde", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66545", "l": "L-cysteinyl-[protein] + S-adenosyl-L-methionine => H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-389083", "l": "Autophosphorylation of PDGF alpha receptors (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3134914", "l": "Beta-catenin migrates to the nucleus (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55960", "l": "4-(trimethylamino)butanoate + ATP + CoA = 4-(trimethylamino)butanoyl-CoA + AMP + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54929", "l": "3-oxo-(9Z)-hexadecenoyl-[ACP] + H(+) + NADPH => (3R)-hydroxy-(9Z)-hexadecenoyl-[ACP] + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-964962", "l": "2xPDKX:2xZn2+ phosphorylates PDX (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-6809309", "l": "MTMR6 binds MTMR9 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8987179", "l": "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33892", "l": "chanoclavine-I + NAD(+) => chanoclavine-I aldehyde + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8955245", "l": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57660", "l": "(+)-valencene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = (+)-nootkatone + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0140475", "l": "spindle pole body anchor activity", "d": ["The binding activity of a protein that brings together the spindle pole body and one or more other molecules, permitting them to function in a coordinated way."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56839", "l": "[PQQ precursor protein] + S-adenosyl-L-methionine <=> 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59753", "l": "L-lysyl-[protein] + tetradecanoyl-CoA => CoA + H(+) + N(6)-tetradecanoyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62593", "l": "(S)-8-oxocitronellyl enol + NADP(+) => (6E)-8-oxogeranial + H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5251959", "l": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57328", "l": "acetyl-CoA + N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:1904767", "l": "octanoic acid binding", "d": ["Binding to octanoic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:71447", "l": "D-alanine(in) + Na(+)(in) = D-alanine(out) + Na(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23739", "l": "5-hydroxyisourate + H2O <=> 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0046429", "l": "4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin)", "d": ["Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69357", "l": "H(+) + hypobromite + L-tyrosyl-[protein] => 3-bromo-L-tyrosyl-[protein] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-3640874", "l": "Ub-RibC-AXIN is degraded by the proteasome (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:28095", "l": "di-trans,octa-cis-undecaprenyl diphosphate + H2O => di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61312", "l": "germacra-1(10),4,11(13)-trien-12-ol + O2 + reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-al + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-418158", "l": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74181", "l": "a ketone + H(+) + NADPH + NH4(+) => a secondary alkyl amine + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "86.287364428028752", "identifiers": [{"i": "GO:0034594", "l": "phosphatidylinositol trisphosphate phosphatase activity", "d": ["Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78236", "l": "D-isoleucine + H2O + O2 => (R)-3-methyl-2-oxopentanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-141200", "l": "MAOB:FAD oxidatively deaminates of PEA (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SCE-75850", "l": "Addition of the third nucleotide on the nascent transcript (Saccharomyces cerevisiae)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62400", "l": "(1R,2S)-ephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61253", "l": "H2O + L-valine + O2 => 3-methyl-2-oxobutanoate + H2O2 + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-427666", "l": "SLC26A3,6 exchange Cl- for HCO3- (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047025", "l": "3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity", "d": ["Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39088", "l": "decanedioyl-CoA + O2 => (2E)-decenedioyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-1247649", "l": "AQP1 tetramer transports CO2 from cytosol to extracellular region (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:62288", "l": "(S)-3-(indol-3-ylmethyl)-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + dimethylallyl diphosphate = (S)-3-{[2-(1,1-dimethylallyl)-indol-3-yl]methyl}-6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrazin-1-one + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46170", "l": "AMP + diphosphate + pentanoyl-CoA => ATP + CoA + pentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6787820", "l": "IL34 dimer binds CSF1R (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58609", "l": "2 L-ascorbate + N-decanoylglycine + O2 => H2O + 2 monodehydro-L-ascorbate radical + N-decanoyl-(2S)-hydroxyglycine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:47971", "l": "a ganglioside GM2 + H2O <=> a ganglioside GM3 + N-acetyl-beta-D-galactosamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38614", "l": "NAD(+) <=> cyclic ADP-beta-D-ribose + H(+) + nicotinamide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110138", "l": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0052772", "l": "brefeldin A esterase activity", "d": ["Catalysis of the hydrolysis of brefeldin A to produce brefeldin A acid. Brefeldin A is also known as gamma,4-dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid lambda-lactone."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-162821", "l": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12470", "l": "26-desgluco-avenacoside A + D-glucose => avenacoside A + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031773", "l": "kisspeptin receptor binding", "d": ["Binding to a kisspeptin receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68753", "l": "alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] => alpha-D-glucose 6-phosphate + O-phospho-L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1799332", "l": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-4084980", "l": "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:25995", "l": "(2E,6E)-farnesyl diphosphate <=> (+)-epi-isozizaene + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:45054", "l": "CoA + O-(2E)-butenoyl-(R)-carnitine => (2E)-butenoyl-CoA + (R)-carnitine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6785648", "l": "MEMO1 binds RHOA:GTP:DIAPH1 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0120325", "l": "NuRD complex binding", "d": ["Binding to a NuRD complex."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0140032", "l": "glycosylation-dependent protein binding", "d": ["Binding to a protein upon glycosylation of the target protein."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0017188", "l": "aspartate N-acetyltransferase activity", "d": ["Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54435", "l": "2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 <=> a 4-H-anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12399", "l": "dTDP-D-galactose + H2O + 2 NADP(+) <=> dTDP-D-galacturonate + 3 H(+) + 2 NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-77095", "l": "Recognition and binding of the mRNA cap by the cap-binding complex  (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5687484", "l": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9626880", "l": "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "95.429121476009584", "identifiers": [{"i": "GO:0001161", "l": "intronic transcription regulatory region sequence-specific DNA binding", "d": ["Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9750666", "l": "ALB binds ST (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9753285", "l": "CYP2E1 monooxygenates APAP to NAPQI (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9033509", "l": "USP9X binds Ub:PEX5L (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-5682802", "l": "LGI3 binds ADAM22,23,synatxin1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42651", "l": "(2,5-ethylene furandicarboxylate)(n) + 2 H2O <=> (2,5-ethylene furandicarboxylate)(n-1) + 2,5-dicarboxyfuran + ethylene glycol + 2 H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9796053", "l": "PRKCI phosphorylates NFE2L2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77501", "l": "(2S)-2-hydroxy-3-phenylpropanenitrile => 2-phenylacetaldehyde + hydrogen cyanide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-2064417", "l": "WWTR1 (TAZ) binds ZO-1 (TJP1) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:20538", "l": "H2O + holo-[ACP] => (R)-4'-phosphopantetheine + apo-[ACP] + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-445813", "l": "Phosphorylation of Smooth Muscle Myosin Light Chains (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-110236", "l": "OGG1 glycosylase mediated recognition and binding of a formamidopyrimidine (FapyG) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-189425", "l": "UROD decarboxylates URO3 to COPRO3 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29373", "l": "2'-deoxyadenosine + phosphate => dAMP + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16899", "l": "a 3beta-hydroxysteroid ester + a diacylglycerol => a 3beta-hydroxysteroid + a triacylglycerol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-5205649", "l": "p62 links damaged mitochondria to LC3 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2161792", "l": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4549382", "l": "Defective ALG1 does not transfer the first Man to the N-glycan precursor (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "92.755328944123519", "identifiers": [{"i": "GO:0033283", "l": "ATPase-coupled organic acid transmembrane transporter activity", "d": ["Enables the transfer of an organic acid from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42847", "l": "6 (S)-methylmalonyl-CoA + 12 H(+) + malonyl-CoA + 5 NADPH <=> 7 CO2 + 7 CoA + 2 H2O + 5 NADP(+) + narbonolide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1604359", "l": "Initial activation of proMMP2 by MMP1, 7 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-8868066", "l": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29133", "l": "H2O + menaquinone-8 + nitrite => menaquinol-8 + nitrate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110219", "l": "Cleavage of thymine by TDG glycosylase (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61446", "l": "an 11a-hydroxytetracycline + H2O + NADP(+) => a tetracycline + H(+) + NADPH + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:64331", "l": "(7Z)-octadecenoyl-CoA + cholesterol <=> cholesteryl (7Z)-octadecenoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72942", "l": "2 Na(+)(out) + propanoate(out) <=> 2 Na(+)(in) + propanoate(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:69653", "l": "2-phenylpropan-2-ol + glutathione disulfide + H2O => cumene hydroperoxide + 2 glutathione", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6782227", "l": "Ligation of newly synthesized repair patch to incised DNA in TC-NER (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685011", "l": "ATR activation at DNA DSBs (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-6798335", "l": "BPGM dimer isomerises 1,3BPG to 2,3BPG (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-9696323", "l": "CNRs bind CNR agonists (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63376", "l": "an omega-methyl-ultra-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-ultra-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74207", "l": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10169", "l": "15,16-dihydrobiliverdin + oxidized 2[4Fe-4S]-[ferredoxin] => biliverdin IXalpha + 2 H(+) + reduced 2[4Fe-4S]-[ferredoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1013020", "l": "Activation of GIRK/Kir3 Channels (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9851946", "l": "FIRRM binds PLK1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-422021", "l": "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19697", "l": "11-cis-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate", "d": [], "t": []}, {"i": "EC:3.1.1.63", "l": "\"11-cis-retinyl-palmitate hydrolase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-450533", "l": "PKCdelta phosphorylates HuR (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0050057", "l": "linamarin synthase activity", "d": ["Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682011", "l": "LC3 binds ATG7 dimer (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11829", "l": "a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O => a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68972", "l": "A + sn-glycerol 3-phosphate = AH2 + dihydroxyacetone phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12175", "l": "alpha-D-glucosamine 6-phosphate + H2O <=> beta-D-fructose 6-phosphate + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5654584", "l": "Activated FGFR1:p-FRS bind to PPTN11 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42034", "l": "2 CO2 + 2 formaldehyde + L-lysyl(36)-[histone H3] + 2 succinate => 2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9619467", "l": "PPM1F dephosphorylates CAMK1 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55210", "l": "(2R)-hydroxyhexadecanal + phosphoethanolamine => (4R)-hydroxysphinganine 1-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-4085331", "l": "PIAS2-1 SUMOylates PARK7 with SUMO1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-5687086", "l": "PAK1,2,3 phosphorylates MAPK6,4 (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36911", "l": "(13Z,16Z,19Z,22Z)-octacosatetraenoyl-CoA + H(+) + malonyl-CoA = 3-oxo-(15Z,18Z,21Z,24Z)-triacontatetraenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:70942", "l": "L-methionine(in) <=> L-methionine(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56319", "l": "3-amino-4-hydroxybenzoate + acetyl-CoA <=> 3-acetylamino-4-hydroxybenzoate + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59632", "l": "D-xylobiose + O2 = D-xylobiono-1,5-lactone + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-166542", "l": "beta-NGF dimer binds to TrkA receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57946", "l": "CO2 + 2 H2O + heme b => H(+) + H2O2 + harderoheme III", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8850529", "l": "RGS proteins bind GNB5 and CCT/TRiC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31027", "l": "2-trans-(+)-abscisate + UDP-alpha-D-glucose = beta-D-glucopyranosyl trans-(+)-abscisate + UDP", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46311", "l": "O2 + progesterone + reduced [NADPH--hemoprotein reductase] <=> 17alpha-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76801", "l": "1-hydroxy-2-butanone + H(+) + NADH + NH4(+) => (2S)-2-aminobutan-1-ol + H2O + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8964274", "l": "G alpha (12) binds BTK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-74843", "l": "atROL binds RBP1 to form RBP1:atROL (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2529020", "l": "CK2 phosphorylates condensin I subunits (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:78135", "l": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a 3-acyl-sn-glycerol = a 1,3-diacylglycerol + a 2-acyl-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-2984226", "l": "PLK1 phosphorylates NEK9 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-8851234", "l": "NTPDase4 hydrolyzes nucleoside triphosphates (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:31733", "l": "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H(+) + H2O => 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-983424", "l": "Budding of COPII coated vesicle (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0004136", "l": "deoxyadenosine kinase activity", "d": ["Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H+."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6808464", "l": "ALDH3B2 oxidises HXAL to PALM (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0047536", "l": "2-aminoadipate transaminase activity", "d": ["Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-451418", "l": "Pellino ubiquitinates IRAK1 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5672824", "l": "Phosphorylated AKT1S1:mTORC1 binds YWHAB (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-199203", "l": "PANK1/3 phosphorylate PanK (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41782", "l": "CMP + H(+) + N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide => beta-D-Gal-(1<->1')-Cer + CMP-N-acetyl-beta-neuraminate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3222072", "l": "DAXX binds Ub-MDM2 and USP7 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-83793", "l": "Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-177931", "l": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008158", "l": "hedgehog receptor activity", "d": ["Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-6781779", "l": "USP13 deubiquitinates BECN1,USP10 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-73794", "l": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21737", "l": "(3S)-3,6-diaminohexanoate => (3S,5S)-3,5-diaminohexanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2161282", "l": "Elastic fibres bind associated proteins (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.5.5", "l": "\"15-cis-phytoene desaturase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-3322009", "l": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:61135", "l": "(2R,3R)-dihydrokaempferol + 2-oxoglutarate + O2 <=> CO2 + H(+) + H2O + kaempferol + succinate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43230", "l": "H(+) + N(5)-methyl-L-glutamine(104)-[histone H2A] + S-adenosyl-L-homocysteine => L-glutamine(104)-[histone H2A] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11995", "l": "L-pipecolate + O2 <=> H(+) + H2O2 + L-1-piperideine-6-carboxylate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17249", "l": "2 Fe(2+) + 2 H2O + H2O2 = 6 H(+) + 2 iron(III) oxide-hydroxide", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8863463", "l": "STON2 binds SYT proteins (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5618093", "l": "ATP hydrolysis by HSP90 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3299680", "l": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0080150", "l": "S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity", "d": ["Catalysis of the reaction: benzoate + S-adenosyl-L-methionine = methylbenzoate + S-adenosyl-L-homocysteine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-69600", "l": "Proteolytic degradation of ubiquitinated-Cdc25A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-6788912", "l": "LHPP:Mg2+ dimer hydrolyses PPi (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-109536", "l": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17418", "l": "ATP + N-acetyl-D-glucosamine => ADP + H(+) + N-acetyl-D-glucosamine 6-phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0003707", "l": "nuclear steroid receptor activity", "d": ["Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:40923", "l": "1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:36820", "l": "(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + H(+) + malonyl-CoA => 3-oxo-(13Z,16Z,19Z,22Z,25Z)-octacosapentaenoyl-CoA + CO2 + CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-9625482", "l": "PTK2 binds activated EGFR (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-3322001", "l": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:63175", "l": "(25S)-3-oxocholest-4-en-26-oyl-CoA <=> (25R)-3-oxocholest-4-en-26-oyl-CoA", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33971", "l": "5''-phosphoribostamycin + H2O = phosphate + ribostamycin", "d": [], "t": []}, {"i": "EC:3.1.3.88", "l": "\"5''-phosphoribostamycin phosphatase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-429415", "l": "SYK binds to integrin alphaIIb beta3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-1358801", "l": "ERBB3 binds RNF41 ubiquitin ligase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3000339", "l": "Phosphorylated BORA binds SCF-beta-TrCp1/2 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:60998", "l": "4-methyl-2-oxopentanoate + H2O2 + NH4(+) => H2O + L-leucine + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5692283", "l": "ALD3A1 oxidises 4HPCP to CXPA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:56618", "l": "1,2,4-trichlorobenzene + chloride + H(+) => (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-9861734", "l": "PDH E1 decarboxylates PYR, transferring acetyl to DLAT (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75478", "l": "D-mannose(out) + n Na(+)(out) <=> D-mannose(in) + n Na(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-9837337", "l": "DCAKD phosphorylates DP-CoA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-212614", "l": "Glutamine transport from astrocytes (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.7.10", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:43582", "l": "AH2 + iminoarginine => A + D-arginine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59737", "l": "L-cysteinyl-[protein] + tetradecanoyl-CoA => CoA + S-tetradecanoyl-L-cysteinyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-110355", "l": "Displacement of MUTYH glycosylase by APEX1 at the AP site (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0009670", "l": "triose-phosphate:phosphate antiporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: triose-phosphate(out) + phosphate(in) = triose-phosphate(in) + phosphate(out)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33538", "l": "H2O + lanosteryl ester <=> a carboxylate + H(+) + lanosterol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-6787403", "l": "GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5662613", "l": "MT3 exchanges zinc for copper (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-421161", "l": "hypoxanthine + H2O + NAD+ => xanthine + NADH + H+ (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-445699", "l": "ATP Hydrolysis By Myosin (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-83788", "l": "Binding of TFIIIC to Type 2 promoter (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-444007", "l": "GAT1-3 mediate Na+/Cl- dependent GABA transport (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59774", "l": "D-sorbopyranose + H2O2 => D-sorbitol + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14894", "l": "D-ornithine => (2R,4S)-2,4-diaminopentanoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-141139", "l": "Trimerization of TRAIL:TRAIL receptor complex (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-174690", "l": "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71324", "l": "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:14400", "l": "(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) <=> (4Z)-2-oxohept-4-enedioate + CO2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-5696007", "l": "ACSF3 ligates CoA-SH to VLCFA (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75911", "l": "H2O + N-acyl-1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine = a fatty acid + H(+) + N-acyl-1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-390929", "l": "HTR1 and 5A receptors can bind serotonin (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21048", "l": "ATP + isopropylamine + L-glutamate = ADP + gamma-L-glutamyl-isopropylamide + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-442393", "l": "ZIP7 mediates zinc efflux from the endoplasmic reticulum (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-1250353", "l": "Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Gallus gallus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17958", "l": "3-oxopropanoate => H2O + propynoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52359", "l": "3'-phosphoadenylyl sulfate + pregnenolone <=> adenosine 3',5'-bisphosphate + H(+) + pregnenolone sulfate", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0016308", "l": "1-phosphatidylinositol-4-phosphate 5-kinase activity", "d": ["Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H+."], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21086", "l": "dermatan 4'-sulfate => chondroitin 4'-sulfate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33172", "l": "D-maltose(in) => D-maltose(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18255", "l": "CO2 + NADPH + pyruvate => (S)-malate + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-70906", "l": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+ (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:33471", "l": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + an N-acyl-(4R)-4-hydroxysphinganine = a 1,2-diacyl-sn-glycerol + an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-877187", "l": "P2X7 mediates loss of intracellular K+ (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9013568", "l": "HES5 gene expression is stimulated by NOTCH3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-69199", "l": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:46368", "l": "a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 = a (9Z,11E,13E)-octadecatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41964", "l": "butanoyl-CoA + O2 = (2E)-butenoyl-CoA + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22521", "l": "all-trans-retinal + H2O + O2 => all-trans-retinoate + H(+) + H2O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-190263", "l": "FGFR3b binds to FGF (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-4720446", "l": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:19203", "l": "ADP + dGMP + H(+) => 2'-deoxyguanosine + ATP", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74360", "l": "coproporphyrin I(out) => coproporphyrin I(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:11792", "l": "H(+) + NADH + O2 + propene = 1,2-epoxypropane + H2O + NAD(+)", "d": [], "t": []}, {"i": "EC:1.14.13.69", "l": "\"alkene monooxygenase\"", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5685604", "l": "SLAMF6 binds SLAMF6 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8853686", "l": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5368586", "l": "DKK promotes clathrin-dependent internalization of LRP6 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-936883", "l": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.13.n3", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:59095", "l": "[(1->3)-alpha-D-glucosyl](n) + sucrose <=> [(1->3)-alpha-D-glucosyl](n+1) + D-fructose", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-6806610", "l": "Keratin filament formation (Bos taurus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42013", "l": "cortisol + NAD(+) => 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9760125", "l": "AcK-NFE2L2-dependent GCLM gene expression (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-8870469", "l": "RGGT geranylgeranylates RAB proteins (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5682826", "l": "LGI1 binds ADAM11 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:22690", "l": "H2O2 + NH4(+) + pyruvate => D-alanine + H2O + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-165692", "l": "Phosphorylation of 4E-BP1 by activated mTORC1 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:77842", "l": "(2S)-2-[(E)-{[(2R,3S,4R,5R)-2,3,4,5-tetrahydroxyoxan-2-yl]methylidene}amino]pentanedioate + H(+) + H2O <=> 2-dehydro-D-glucose + L-glutamate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-5225649", "l": "RBBP7 binds histone H3 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-75850", "l": "Addition of the third nucleotide on the nascent transcript (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55558", "l": "an oxoeicosatetraenoate + H2O => a hydroperoxyeicosatetraenoate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-8932355", "l": "26S proteasome degrades Ub-NFE2L2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12241", "l": "acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH => 6-methylsalicylate + 3 CO2 + 4 CoA + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21454", "l": "a [peptide]-C-terminal (2S)-2-hydroxyglycine + H2O + 2 monodehydro-L-ascorbate radical => a [peptide]-C-terminal glycine + 2 L-ascorbate + O2", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6782943", "l": "UV-DDB ubiquitinates XPC (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-8867041", "l": "EGFR phosphorylates EPS15 (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66343", "l": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) + ATP + H2O <=> 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out) + ADP + H(+) + phosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5668454", "l": "K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-73722", "l": "Phosphorylation of UBF-1:rDNA Promoter (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9821395", "l": "PAXIP1 binds PAGR1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:48106", "l": "H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine => N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:41660", "l": "dihydrosanguinarine + NAD(+) = NADH + sanguinarine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49807", "l": "2-methylpropan-1-amine + FMNH2 + O2 <=> FMN + 2 H(+) + H2O + N-(2-methylpropyl)hydroxylamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:67233", "l": "(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+) => (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13978", "l": "D-serine => NH4(+) + pyruvate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12444", "l": "hexadecanal + NADP(+) = (2E)-hexadecenal + H(+) + NADPH", "d": [], "t": []}, {"i": "EC:1.3.1.27", "l": "\"2-hexadecenal reductase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9853372", "l": "FIRRM binds PPP1CC (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:30704", "l": "H(+) + salicylate => CO2 + phenol", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-8985966", "l": "p-Y701-STAT1 binds p-Y705-STAT3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0008257", "l": "protein histidine tele-kinase activity", "d": ["Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-111898", "l": "Phosphorylation of cPLA2 by ERK-2 (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76633", "l": "Ca(2+)(out) + n H(+)(in) => Ca(2+)(in) + n H(+)(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9694333", "l": "3CLp forms a homodimer (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-6814254", "l": "PNPLA6 hydrolyzes LysoPtdCho (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-5651654", "l": "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0097077", "l": "copper ion sensor activity", "d": ["Binding to and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:75494", "l": "25-hydroxyvitamin D3 sulfate(out) + n H(+)(out) <=> 25-hydroxyvitamin D3 sulfate(in) + n H(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57674", "l": "2beta-hydroxy-5-epi-aristolochene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] => (+)-5-epi-aristolochene + O2 + reduced [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-114261", "l": "Cleavage of Procaspase-7 by the apoptosome (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:39630", "l": "(3R)-hydroxy-(16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontahexaenoyl-CoA <=> (2E,16Z,19Z,22Z,25Z,28Z,31Z)-tetratriacontaheptaenoyl-CoA + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-351987", "l": "SLC6A6-mediated uptake of taurine and beta-alanine (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:10315", "l": "H(+) + NADH + O2 + terephthalate <=> (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:15399", "l": "2 chloride + formaldehyde + 2 H(+) => dichloromethane + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-1912372", "l": "Fringe-modified Pre-NOTCH is cleaved by FURIN (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73136", "l": "4',7,8-trihydroxyflavone + S-adenosyl-L-methionine => 4',7-dihydroxy-8-methoxyflavone + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:21034", "l": "acceptor beta-D-glucuronoside + H(+) + UDP => glucuronate acceptor + UDP-alpha-D-glucuronate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-1363314", "l": "p107 (RBL1) binds CyclinE/A:CDK2 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:2.4.1.130", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0031707", "l": "endothelin A receptor binding", "d": ["Binding to an endothelin A receptor."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-PFA-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Plasmodium falciparum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38762", "l": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine <=> 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54668", "l": "pre-alpha-onocerin = alpha-onocerin", "d": [], "t": []}, {"i": "EC:5.4.99.66", "l": "\"alpha-onocerin synthase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-9708104", "l": "PDE5A dimer binds PDE5A inhibitors (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-74736", "l": "GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23509", "l": "(7R)-7-(4-carboxybutanamido)cephalosporanate + H2O => (7R)-7-aminocephalosporanate + glutarate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.3.8.2", "l": "\"4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:72651", "l": "1,6-dihydroxyphenazine N(5)-oxide + NADPH + O2 = 1,6-dihydroxyphenazine N(5),N(10)-dioxide + H2O + NADP(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.4.13.5", "l": "\"Xaa-methyl-His dipeptidase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:52972", "l": "a C2-C8-saturated long-chain fatty acyl-[ACP] + O2 + reduced [flavodoxin] = a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + H(+) + H2O + oxidized [flavodoxin]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:49389", "l": "UDP-alpha-D-glucose + validoxylamine A => H(+) + UDP + validamycin A", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51088", "l": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13,14-epoxy-(4Z,7Z,10Z,16Z,19Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-6809309", "l": "MTMR6 binds MTMR9 (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:73564", "l": "dGDP(out) + UTP(in) => dGDP(in) + UTP(out)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-195690", "l": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-3204303", "l": "MRE11 binds cytosolic DNA (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-4088130", "l": "PLK1 binds FOXM1 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-449911", "l": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial] (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-374723", "l": "Nociceptin receptor binds to nociceptin (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:3.1.21.5", "l": "\"type III site-specific deoxyribonuclease\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-158441", "l": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DDI-3299682", "l": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) (Dictyostelium discoideum)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68278", "l": "CoA + O-butanoyl-L-seryl-[protein] => butanoyl-CoA + L-seryl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-3321805", "l": "NSL acetylates histone H4 (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:55038", "l": "an N,N,N-trimethylornithine lipid + H(+) + S-adenosyl-L-homocysteine => an N,N-dimethylornithine lipid + S-adenosyl-L-methionine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-9013159", "l": "CDC42 GEFs activate CDC42 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SPO-1482539", "l": "1-acyl LPG is acylated to PG by LPGAT (Schizosaccharomyces pombe)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44563", "l": "4-hydroxybenzoate + all-trans-heptaprenyl diphosphate <=> 4-hydroxy-3-all-trans-heptaprenylbenzoate + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54323", "l": "a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-9753278", "l": "ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:13476", "l": "H2O + L-tryptophan + NAD(+) <=> H(+) + indole-3-pyruvate + NADH + NH4(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:32067", "l": "8-oxoguanine + H(+) + H2O = NH4(+) + urate", "d": [], "t": []}, {"i": "EC:3.5.4.32", "l": "\"8-oxoguanine deaminase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44326", "l": "butanoate + glycerol + H(+) => 1-butyrylglycerol + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53444", "l": "O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 11beta,17beta-dihydroxyandrost-4-ene-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8950362", "l": "EBI3:CANX binds IL12A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:44596", "l": "a fatty acyl-[ACP] + H2O = a fatty acid + H(+) + holo-[ACP]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "90.858242952019168", "identifiers": [{"i": "GO:0140995", "l": "histone H2A kinase activity", "d": ["Catalysis of the transfer of a phosphate group to a histone H2A."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-XTR-8959719", "l": "SHPK phosphorylates Sedo to Sedo7P (Xenopus tropicalis)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CEL-420598", "l": "Nectin-1:Nectin-4 trans heterodimer formation (Caenorhabditis elegans)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58883", "l": "4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + H(+) + O2 <=> 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "82.597043153557706", "identifiers": [{"i": "GO:0005381", "l": "iron ion transmembrane transporter activity", "d": ["Enables the transfer of iron (Fe) ions from one side of a membrane to the other."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18021", "l": "a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:38524", "l": "1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O => (9Z)-octadecenoate + 2-(9Z,12Z-octadecadienoyl)-glycerol + H(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2395768", "l": "LPL hydrolyses TGs from mature CMs (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:74297", "l": "n H(+)(in) + serotonin(out) => n H(+)(out) + serotonin(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:57969", "l": "germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] => 8-epi-inunolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-71588", "l": "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0022873", "l": "protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity", "d": ["Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-194153", "l": "ABCC3 transports bile salts from cytosol to extracellular region (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-5696408", "l": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-8982641", "l": "ADRB2:GRK complex dissociates to Phosphorylated ADRB2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "EC:1.14.99.32", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-GGA-3371435", "l": "Constitutive phosphorylation by GSK3 (Gallus gallus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-1604368", "l": "Autocatalytic activation of bound proMMP2 (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-5693578", "l": "TDP1 and TDP2 process unligatable DSB ends (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0035273", "l": "phthalate binding", "d": ["Binding to a phthalate, any ester or salt of phthalic acid."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-5626699", "l": "MARK4 binds ODF2 in the centriole (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "79.323347803118935", "identifiers": [{"i": "GO:0030695", "l": "GTPase regulator activity", "d": ["Binds to and modulates the activity of a GTPase."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-9018745", "l": "RHOQ GAPs stimulate RHOQ GTPase activity (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-2089971", "l": "Secretion of collagens (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:51869", "l": "dimethylallyl diphosphate + umbelliferone => demethylsuberosin + diphosphate", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:54081", "l": "5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine => 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DRE-1504190", "l": "DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Danio rerio)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:58837", "l": "24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 => 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:76674", "l": "furfural + H2O + NADP(+) <=> 2-furoate + 2 H(+) + NADPH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-191114", "l": "Digestion of branched starch (amylopectin) by extracellular amylase (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-74718", "l": "Internalisation of the insulin receptor (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:23030", "l": "acetyl-[ACP] + N(6)-carboxybiotinyl-L-lysyl-[protein] => malonyl-[ACP] + N(6)-biotinyl-L-lysyl-[protein]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "ic": "100", "identifiers": [{"i": "GO:0015624", "l": "ABC-type ferric-enterobactin transporter activity", "d": ["Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in)."], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-70859", "l": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29100", "l": "a menaquinone + 5 H(+)(in) + NADH => a menaquinol + 4 H(+)(out) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-163217", "l": "Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-372448", "l": "SLC25A12,13 exchange L-Glu and L-Asp (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-BTA-9013109", "l": "RHOC GEFs activate RHOC (Bos taurus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:66620", "l": "5alpha-cholest-7-en-3-one + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (25S)-Delta7-dafachronate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:17483", "l": "2 cob(II)alamin + NADH => 2 cob(I)alamin + H(+) + NAD(+)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:42124", "l": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = androsterone + H(+) + NADH", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:53169", "l": "H2O + N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine => 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+) + N-hexadecanoylethanolamine", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-193824", "l": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12588", "l": "a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 (d18:1(4E)) + H(+) + UDP", "d": [], "t": []}, {"i": "EC:2.4.1.92", "l": "\"(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:16601", "l": "L-aspartate = fumarate + NH4(+)", "d": [], "t": []}, {"i": "EC:4.3.1.1", "l": "\"aspartate ammonia-lyase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:68091", "l": "a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) + N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] <=> a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-140769", "l": "factor VII -> factor VIIa (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
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{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:29465", "l": "K(+)(out) => K(+)(in)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-HSA-350578", "l": "NQO1 interaction with ODC (Homo sapiens)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-CFA-2467809", "l": "ESPL1 (Separase) cleaves centromeric cohesin (Canis familiaris)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:18521", "l": "licodione + S-adenosyl-L-methionine = 2'-O-methyllicodione + H(+) + S-adenosyl-L-homocysteine", "d": [], "t": []}, {"i": "EC:2.1.1.65", "l": "\"licodione 2'-O-methyltransferase\"", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-RNO-9839401", "l": "TGFBR3 degradation (Rattus norvegicus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-DME-1605624", "l": "Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 (Drosophila melanogaster)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-MMU-9627056", "l": "Procaspase 9 forms dimer (Mus musculus)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "REACT:R-SSC-6801242", "l": "TRIAP1 binds PRELID1, PRELID3A (Sus scrofa)", "d": [], "t": []}], "taxa": []}
{"type": "biolink:MolecularActivity", "identifiers": [{"i": "RHEA:12541", "l": "ATP + L-alanine + tRNA(Ala) => AMP + diphosphate + L-alanyl-tRNA(Ala)", "d": [], "t": []}], "taxa": []}
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